FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Bare, J
AF Bare, Jane
TI Recommendation for land use impact assessment: first steps into
framework, theory, and implementation
SO CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY
LA English
DT Article
DE Land use; Life cycle impact assessment (LCIA); Life cycle assessment
(LCA); Sustainability metrics; Biodiversity; Ecosystem services
ID ECOSYSTEM SERVICES; NATURAL-ENVIRONMENT; CONSERVATION; BIODIVERSITY;
LANDSCAPE; VALUES
AB This article presents research, criteria, framework, and guidance which were developed to provide recommendations for land use impact assessment specific to biofuels, but applicable to a variety of land uses. The criteria for land use modeling were developed along with a 10-step framework including a comprehensive ecosystem services valuation of scenarios. This research program is defined which includes the development of a user-friendly ecosystem services tool with accompanying default values and recommendations on input parameters which are necessary to develop the scenarios, integration curves, maps, and ecosystem profiles of each scenario. Based on these scenarios, curves, maps, and profiles, additional recommendations may be made on land use practices or regional selections. Finally, a discussion of implementation of the theory behind this methodology focuses on an analysis of biofuels.
C1 US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, Off Res & Dev, Cincinnati, OH 45268 USA.
RP Bare, J (reprint author), US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, Off Res & Dev, 26 W MLK Dr, Cincinnati, OH 45268 USA.
EM bare.jane@epa.gov
NR 68
TC 15
Z9 15
U1 0
U2 20
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1618-954X
J9 CLEAN TECHNOL ENVIR
JI Clean Technol. Environ. Policy
PD FEB
PY 2011
VL 13
IS 1
BP 7
EP 18
DI 10.1007/s10098-010-0290-8
PG 12
WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental;
Environmental Sciences
SC Science & Technology - Other Topics; Engineering; Environmental Sciences
& Ecology
GA 709TJ
UT WOS:000286464000002
ER
PT J
AU Keller, TA
Shenk, GW
Williams, MR
Batiuk, RA
AF Keller, Troy A.
Shenk, Gary W.
Williams, Michael R.
Batiuk, Richard A.
TI DEVELOPMENT OF A NEW INDICATOR OF POLLUTANT LOADS AND ITS APPLICATION TO
THE CHESAPEAKE BAY WATERSHED
SO RIVER RESEARCH AND APPLICATIONS
LA English
DT Article
DE fluvial transport; large rivers; nutrient management; estuary;
indicator; restoration
ID RHODE RIVER WATERSHEDS; GULF-OF-MEXICO; AIR-TEMPERATURE; ALGAL BLOOMS;
NITROGEN; EUTROPHICATION; PHOSPHORUS; DISCHARGES; NUTRIENTS;
PRECIPITATION
AB Pollutant load reductions are often required to restore aquatic ecosystems experiencing eutrophication. Loads can be estimated using watershed models or data from monitoring stations, however data availability can limit the timeliness or comprehensiveness of the load estimates. We developed an approach to address this challenge that used watershed model results to estimate the proportion of annual nonpoint source nitrogen (N), phosphorus (P) and sediment (Sed) loads derived from unmonitored catchments. This proportion was multiplied by the nonpoint portion of United States Geological Survey (USGS) estimated annual river loads to account for annual variation in hydrologic conditions. Total loads were calculated as the sum of measured river loads, reported point sources from unmonitored areas and the estimated nonpoint source loads from unmonitored catchments. We applied this approach to the Chesapeake Bay because of its socio-economic and ecological importance. Median watershed loads for N, P and Sed were 140, 6.4 and 3030 Mg year(-1), respectively (1990-2004). Nonpoint source loads from the monitored areas constituted the greatest source of N, P and Sed (55, 47 and 74% respectively) to the Bay. The high N, P and Sed yield rates (7.3, 0.38 and 99 kg ha(-1) year(-1), respectively) from nonpoint loads originating from unmonitored areas near the Bay resulted in 25, 32 and 26% (N, P and Sed, respectively) of the Bay's total loads (excluding direct atmospheric deposition, shoreline erosion and oceanic inputs). Disproportionately high loads of P and Seds were associated with years that experienced elevated discharge whereas N loads were directly related to discharge. Error estimates indicated that our methods were most reliable for N (+/- 6%) but reasonable for P (+/- 22%) and provide an effective technique for the timely estimation of pollutant loads from watersheds with unmonitored catchments. Management strategies that decrease N deposition and reduce runoff to control P and Sed transport will effectively reduce pollutant loads. Published in 2010 by John Wiley & Sons, Ltd.
C1 [Keller, Troy A.] Columbus State Univ, Environm Sci Program, Columbus, GA 31907 USA.
[Shenk, Gary W.; Batiuk, Richard A.] US EPA, Chesapeake Bay Program Off, Annapolis, MD 21403 USA.
[Williams, Michael R.] Univ Maryland, Ctr Environm Sci, Annapolis Synth Ctr, Annapolis, MD 21401 USA.
RP Keller, TA (reprint author), Columbus State Univ, Environm Sci Program, 4225 Univ Ave, Columbus, GA 31907 USA.
EM keller_troy@colstate.edu
FU Chesapeake Bay Program Office
FX This effort was facilitated by Bill Dennison (University of Maryland);
Jeff Raffensperger, Scott Phillips, Doug Moyer, Steve Preston and Mike
Langland (US Geological Survey); Lewis Linker, the Non-tidal Water
Quality Workgroup (CBP) and Ning Zhou (Virginia Institute of
Technology). The manuscript benefited from comments by two anonymous
reviewers. This research was supported by a Chesapeake Bay Program
Office grant to University of Maryland Center for Environmental Science.
NR 44
TC 2
Z9 2
U1 3
U2 10
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1535-1459
J9 RIVER RES APPL
JI River Res. Appl.
PD FEB
PY 2011
VL 27
IS 2
DI 10.1002/rra.1351
PG 11
WC Environmental Sciences; Water Resources
SC Environmental Sciences & Ecology; Water Resources
GA 724TT
UT WOS:000287599800006
ER
PT J
AU Adjalle, KD
Vu, KD
Tyagi, RD
Brar, SK
Valero, JR
Surampalli, RY
AF Adjalle, K. D.
Vu, K. D.
Tyagi, R. D.
Brar, S. K.
Valero, J. R.
Surampalli, R. Y.
TI Optimization of spray drying process for Bacillus thuringiensis
fermented wastewater and wastewater sludge
SO BIOPROCESS AND BIOSYSTEMS ENGINEERING
LA English
DT Article
DE Bacillus thuringiensis; Wastewater; Sludge; Spray drying; Response
surface methodology
ID RESPONSE-SURFACE METHODOLOGY; BIOPESTICIDES; FORMULATIONS; MORPHOLOGY;
PARTICLES; RECOVERY
AB Response surface methodology was used to optimize spray drying process for producing biopesticide powders of Bacillus thuringiensis by using fermented broth of starch industry wastewater and wastewater sludge. Analysis of variance was carried out using number of viable spores in the powder as dependent variable. The determination coefficients of models were 92 and 94% for fermented broth of starch industry wastewater and wastewater sludge, respectively. Under the optimal conditions of the operational parameters of spray drying, the numbers of viable spores were 2.2 x 10(8) and 1.3 x 10(8) CFU/mg in the dry powders for starch industry wastewater and wastewater sludge respectively, with a loss of viable spores of 18 and 13% when compared with their respective fermented broths. The entomotoxicity (measured by the bioassay method) of the powders obtained under optimal conditions showed a loss of 28 and 18% when compared with the fermented broth of starch industry wastewater and wastewater sludge, respectively. The optimized results of spray drying were used for field application calculations. The volume of fermented broth required to produce powder formulated product when compared with the volume required for liquid formulation product in order to treat 1 ha of balsam fir was less and offered several advantages.
C1 [Adjalle, K. D.; Vu, K. D.; Tyagi, R. D.; Brar, S. K.; Valero, J. R.] Univ Quebec, INRS ETE, Quebec City, PQ G1K 9A9, Canada.
[Surampalli, R. Y.] US EPA, Kansas City, KS 66117 USA.
RP Tyagi, RD (reprint author), Univ Quebec, INRS ETE, 490 Rue Couronne, Quebec City, PQ G1K 9A9, Canada.
EM tyagi@ete.inrs.ca
FU Natural Sciences and Engineering Research Council of Canada [A4984,
STP235071, Canada Research Chair]; INRS-ETE; FQRNT (ENC); SOPFIM
(Societe de Protection des Forets contre les Insectes et Maladies)
FX The authors are sincerely thankful to the Natural Sciences and
Engineering Research Council of Canada (Grants A4984, STP235071 and
Canada Research Chair), INRS-ETE and FQRNT (ENC) for financial support.
The views and opinions expressed in this article are those of authors.
Kokou Adjalle is grateful to SOPFIM (Societe de Protection des Forets
contre les Insectes et Maladies) for the Smirnoff scholarship.
NR 27
TC 10
Z9 10
U1 2
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1615-7591
J9 BIOPROC BIOSYST ENG
JI Bioprocess. Biosyst. Eng.
PD FEB
PY 2011
VL 34
IS 2
BP 237
EP 246
DI 10.1007/s00449-010-0466-y
PG 10
WC Biotechnology & Applied Microbiology; Engineering, Chemical
SC Biotechnology & Applied Microbiology; Engineering
GA 706BO
UT WOS:000286190600014
PM 20835715
ER
PT J
AU Pham, TTH
Tyagi, RD
Brar, SK
Surampalli, RY
AF Pham, T. T. H.
Tyagi, R. D.
Brar, S. K.
Surampalli, R. Y.
TI Effect of ultrasonication and Fenton oxidation on biodegradation of
bis(2-ethylhexyl) phthalate (DEHP) in wastewater sludge
SO CHEMOSPHERE
LA English
DT Article
DE Aerobic digestion; Bis(2-ethylhexyl) phthalate; Bacillus thuringiensis;
Fenton oxidation; Fermentation; Ultrasonication
ID ANAEROBIC-DIGESTION; SEWAGE-SLUDGE; DI-(2-ETHYLHEXYL) PHTHALATE;
ENVIRONMENTAL FATE; SECONDARY SLUDGE; ESTERS; PRETREATMENT; DEGRADATION;
METABOLITES; REMOVAL
AB The presence of bis(2-ethylhexyl) phthalate (DEHP) and its metabolites, i.e. 2-ethylhexanol, 2-ethylhexanal, and 2-ethylhexanoic acid in wastewater sludge (WWS) were investigated during aerobic digestion and Bacillus thuringiensis (Bt)-based fermentation of WWS. Ultrasonication and Fenton oxidation pretreatment was applied to improve biodegradability of WWS and bioavailability of the target compounds for digestion and fermentation. DEHP and 2-ethylhexanoic acid were observed at higher concentration, meanwhile 2-ethylhexanol and 2-ethylhexanal were observed at lower concentration in WWS. After 20-day aerobic digestion, DEHP removal was 72%, 89%, and 85%, and 2-ethylhexanoic acid removal was 71%, 84%, 79%, respectively for raw, ultrasonicated, and Fenton-oxidized sludges. Bt was found to degrade DEHP, leading to DEHP removal of 21%, 40%, and 30%, respectively for raw, ultrasonicated, and Fenton-oxidized sludges in the fermentation. The results suggested that aerobic stabilization and Bt-based fermentation can remove the phthalates, and pre-treatment of WWS was also effective in improvement of DEHP biodegradation. Hence. Bt-based biopesticide production from WWS can be applied safely when taking into consideration the phthalate contaminants. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Pham, T. T. H.; Tyagi, R. D.; Brar, S. K.] Univ Quebec, INRS ETE, Quebec City, PQ G1K 9A9, Canada.
[Surampalli, R. Y.] US EPA, Kansas City, KS 66117 USA.
RP Tyagi, RD (reprint author), Univ Quebec, INRS ETE, 490 Rue Couronne, Quebec City, PQ G1K 9A9, Canada.
EM tyagi@ete.inrs.ca
FU Natural Sciences and Engineering Research Council of Canada [A4984,
STP235071]; NSERC; INRS-ETE
FX The authors are sincerely thankful to the Natural Sciences and
Engineering Research Council of Canada (Grants A4984, STP235071, Canada
Research Chair), NSERC (DG) and INRS-ETE for financial support. The
views or opinions expressed in this article are those of the authors and
should not be construed as opinions of the US Environmental Protection
Agency.
NR 37
TC 19
Z9 22
U1 1
U2 41
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
J9 CHEMOSPHERE
JI Chemosphere
PD FEB
PY 2011
VL 82
IS 6
BP 923
EP 928
DI 10.1016/j.chemosphere.2010.10.035
PG 6
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 721FA
UT WOS:000287337800021
PM 21094970
ER
PT J
AU Wheeler, AJ
Xu, XH
Kulka, R
You, HY
Wallace, L
Mallach, G
Van Ryswyk, K
MacNeill, M
Kearney, J
Dabek-Zlotorzynska, E
Wang, D
Poon, R
Williams, R
Stocco, C
Anastassopoulos, A
Miller, JD
Dales, R
Brook, JR
AF Wheeler, Amanda J.
Xu, Xiaohong
Kulka, Ryan
You, Hongyu
Wallace, Lance
Mallach, Gary
Van Ryswyk, Keith
MacNeill, Morgan
Kearney, Jill
Dabek-Zlotorzynska, Ewa
Wang, Daniel
Poon, Raymond
Williams, Ron
Stocco, Corinne
Anastassopoulos, Angelos
Miller, J. David
Dales, Robert
Brook, Jeffrey R.
TI Windsor, Ontario Exposure Assessment Study: Design and Methods
Validation of Personal, Indoor, and Outdoor Air Pollution Monitoring
SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION
LA English
DT Article
ID AIRBORNE PARTICULATE MATTER; ASTHMATIC-CHILDREN; ELEMENTARY
SCHOOLCHILDREN; ACTIVITY PATTERNS; MEASUREMENT ERROR; OXIDATIVE STRESS;
TIME-ACTIVITY; BALTIMORE; PARTICLES; AMBIENT
AB The Windsor, Ontario Exposure Assessment Study evaluated the contribution of ambient air pollutants to personal and indoor exposures of adults and asthmatic children living in Windsor, Ontario, Canada. In addition, the role of personal, indoor, and outdoor air pollution exposures upon asthmatic children's respiratory health was assessed. Several active and passive sampling methods were applied, or adapted, for personal, indoor, and outdoor residential monitoring of nitrogen dioxide, volatile organic compounds, particulate matter (PM; PM <= 2.5 mu m [PM(2.5)] and <= 10 mu m [PM(10)] in aerodynamic diameter), elemental carbon, ultrafine particles, ozone, air exchange rates, allergens in settled dust, and particulate-associated metals. Participants completed five consecutive days of monitoring during the winter and summer of 2005 and 2006. During 2006, in addition to undertaking the air pollution measurements, asthmatic children completed respiratory health measurements (including peak flow meter tests and exhaled breath condensate) and tracked respiratory symptoms in a diary. Extensive quality assurance and quality control steps were implemented, including the collocation of instruments at the National Air Pollution Surveillance site operated by Environment Canada and at the Michigan Department of Environmental Quality site in Allen Park, Detroit, MI. During field sampling, duplicate and blank samples were also completed and these data are reported. In total, 50 adults and 51 asthmatic children were recruited to participate, resulting in 922 participant days of data. When comparing the methods used in the study with standard reference methods, field blanks were low and bias was acceptable, with most methods being within 20% of reference methods. Duplicates were typically within less than 10% of each other, indicating that study results can be used with confidence. This paper covers study design, recruitment, methodology, time activity diary, surveys, and quality assurance and control results for the different methods used.
C1 [Wheeler, Amanda J.; Kulka, Ryan; You, Hongyu; Mallach, Gary; Van Ryswyk, Keith; MacNeill, Morgan; Kearney, Jill; Stocco, Corinne] Hlth Canada, Air Hlth Sci Div, Ottawa, ON K1A 0K9, Canada.
[Xu, Xiaohong] Univ Windsor, Dept Civil & Environm Engn, Windsor, ON N9B 3P4, Canada.
[Dabek-Zlotorzynska, Ewa; Wang, Daniel] Environm Canada, Anal & Air Qual Div, Ottawa, ON K1A 0H3, Canada.
[Poon, Raymond] Hlth Canada, Hazard Identificat Div, Ottawa, ON K1A 0K9, Canada.
[Williams, Ron] US EPA, Exposure Measurements & Anal Branch, Res Triangle Pk, NC 27711 USA.
[Anastassopoulos, Angelos] Carleton Univ, Dept Civil & Environm Engn, Ottawa, ON K1S 5B6, Canada.
[Miller, J. David] Carleton Univ, Dept Chem, Ottawa, ON K1S 5B6, Canada.
[Dales, Robert] Hlth Canada, Populat Studies Div, Ottawa, ON K1A 0K9, Canada.
[Brook, Jeffrey R.] Environm Canada, Air Qual Res Div, Toronto, ON, Canada.
RP Wheeler, AJ (reprint author), Hlth Canada, Air Hlth Sci Div, 269 Laurier Ave W,3-080, Ottawa, ON K1A 0K9, Canada.
EM amanda.wheeler@hc-sc.gc.ca
RI Wallace, Lance/K-7264-2013; Rasmussen, Pat/R-8176-2016;
OI Rasmussen, Pat/0000-0001-6748-4255; Wheeler, Amanda/0000-0001-9288-8163;
Wallace, Lance/0000-0002-6635-2303
FU BAQS through Health Canada
FX The participants and their families are gratefully thanked for their
contributions to these 2 yr of data collection; without them, none of
this research would have been possible. The careful field work
undertaken by the numerous field technicians from Health Canada and the
University of Windsor is appreciated. The authors would like to
acknowledge contributions from Dr. Paul Villeneuve (Health Canada) for
the power calculation; Alice Grgicak-Mannion (Great Lakes Institute for
Environmental Research, University of Windsor) for the map of
residential locations; Mark Davey (University of Washington), Steve
Ferguson, and Dr. Mike Wolfson (Harvard School of Public Health) for
their guidance on methods and laboratory analyses; Sandy Benetti of
Environment Canada for her help in the initial coordination of the
laboratory activities and sample analyses; Don Fugler of the Canadian
Mortgage and Housing Corporation and Dr. Russell Dietz of Brookhaven
National Laboratory for their support with AER measurements; Environment
Canada and MDEQ for permitting the authors to locate instruments at the
College Road and Allen Park sites and access to their data for the
method comparisons; and Dr. Markey Johnson and Dr. Scott Weichenthal
from Health Canada for conducting the internal review. BAQS provided
funding through Health Canada. Although this work was reviewed by EPA
and approved for publication, it may not necessarily reflect official
agency policy.
NR 56
TC 8
Z9 8
U1 1
U2 22
PU AIR & WASTE MANAGEMENT ASSOC
PI PITTSBURGH
PA ONE GATEWAY CENTER, THIRD FL, PITTSBURGH, PA 15222 USA
SN 1047-3289
J9 J AIR WASTE MANAGE
JI J. Air Waste Manage. Assoc.
PD FEB
PY 2011
VL 61
IS 2
BP 142
EP 156
DI 10.3155/1047-3289.61.2.142
PG 15
WC Engineering, Environmental; Environmental Sciences; Meteorology &
Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA 717UY
UT WOS:000287074100003
PM 21387932
ER
PT J
AU Valari, M
Menut, L
Chatignoux, E
AF Valari, Myrto
Menut, Laurent
Chatignoux, Edouard
TI Using a Chemistry Transport Model to Account for the Spatial Variability
of Exposure Concentrations in Epidemiologic Air Pollution Studies
SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION
LA English
DT Article
ID TIME-SERIES; PARTICULATE MATTER; MEASUREMENT-ERROR; HEALTH; POLLUTANTS;
MORTALITY; OZONE; PHILADELPHIA; DISEASE; SYSTEM
AB Environmental epidemiology and more specifically time-series analysis have traditionally used area-averaged pollutant concentrations measured at central monitors as exposure surrogates to associate health outcomes with air pollution. However, spatial aggregation has been shown to contribute to the overall bias in the estimation of the exposure-response functions. This paper presents the benefit of adding features of the spatial variability of exposure by using concentration fields modeled with a chemistry transport model instead of monitor data and accounting for human activity patterns. On the basis of county-level census data for the city of Paris, France, and a Monte Carlo simulation, a simple activity model was developed accounting for the temporal variability between working and evening hours as well as during transit. By combining activity data with modeled concentrations, the downtown, suburban, and rural spatial patterns in exposure to nitrogen dioxide, ozone, and PM2.5 (particulate matter [PM] <= 10 mu m in aerodynamic diameter) were captured and parametrized. Exposures predicted with this model were used in a time-series study of the short-term effect of air pollution on total nonaccidental mortality for the 4-yr period from 2001 to 2004. It was shown that the time series of the exposure surrogates developed here are less correlated across co-pollutants than in the case of the area-averaged monitor data. This led to less biased exposure-response functions when all three co-pollutants were inserted simultaneously in the same regression model. This finding yields insight into pollutant-specific health effects that are otherwise masked by the high correlation among co-pollutants.
C1 [Valari, Myrto; Menut, Laurent] Ecole Polytech, Meteorol Dynam Lab, Inst Pierre Simon Laplace, Palaiseau, France.
[Chatignoux, Edouard] Reg Hlth Observ Paris Ile de France Reg, Paris, France.
RP Valari, M (reprint author), US EPA, Atmospher Modeling Div, Mail Drop E243-02,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM Valari.Myrto@epa.gov
RI Wang, Linden/M-6617-2014; Menut, Laurent/O-2296-2016
OI Menut, Laurent/0000-0001-9776-0812
NR 42
TC 9
Z9 9
U1 0
U2 10
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1096-2247
EI 2162-2906
J9 J AIR WASTE MANAGE
JI J. Air Waste Manage. Assoc.
PD FEB
PY 2011
VL 61
IS 2
BP 164
EP 179
DI 10.3155/1047-3289.61.2.164
PG 16
WC Engineering, Environmental; Environmental Sciences; Meteorology &
Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA 717UY
UT WOS:000287074100005
PM 21387934
ER
PT J
AU Wahman, DG
Katz, LE
Speitel, GE
AF Wahman, David G.
Katz, Lynn E.
Speitel, Gerald E., Jr.
TI Performance and biofilm activity of nitrifying biofilters removing
trihalomethanes
SO WATER RESEARCH
LA English
DT Article
DE Trihalomethanes; Cometabolism; Nitrification; Disinfection by-products;
Drinking water
ID HALOACETIC ACIDS; ACTIVATED CARBON; DRINKING-WATER;
NITROSOMONAS-EUROPAEA; ENRICHMENT CULTURES; RATE COEFFICIENTS; MIXED
CULTURE; BIODEGRADATION; COMETABOLISM; UNCERTAINTIES
AB Nitrifying biofilters seeded with three different mixed-culture sources removed trichloromethane (TCM) and dibromochloromethane (DBCM) with removals reaching 18% for TCM and 75% for DBCM. In addition, resuspended biofilm removed TCM, bromodichloromethane (BDCM), DBCM, and tribromomethane (TBM) in backwash batch kinetic tests, demonstrating that the biofilters contained organisms capable of biotransforming the four regulated trihalomethanes (THMs) commonly found in treated drinking water. Upon the initial and subsequent increased TCM addition, total ammonia nitrogen (TOTNH(3)) removal decreased and then reestablished, indicating an adjustment by the biofilm bacteria. In addition, changes in DBCM removal indicated a change in activity related to DBCM. The backwash batch kinetic tests provided a useful tool to evaluate the biofilm's bacteria. Based on these experiments, the biofilters contained bacteria with similar THM removal kinetics to those seen in previous batch kinetic experiments. Overall, performance or selection does not seem based specifically on nutrients, source water, or source cultures and most likely results from THM product toxicity, and the use of GAC media appeared to offer benefits over anthracite for biofilter stability and long-term performance, although the reasons for this advantage are not apparent based on research to date. Published by Elsevier Ltd.
C1 [Wahman, David G.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
[Katz, Lynn E.; Speitel, Gerald E., Jr.] Univ Texas Austin, Dept Civil Architectural & Environm Engn, Austin, TX 78712 USA.
RP Wahman, DG (reprint author), US EPA, Off Res & Dev, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM wahman.david@epa.gov
OI Wahman, David/0000-0002-0167-8468
FU American Water Works Association Research Foundation (AwwaRF); Texas
Advanced Technology Research Program (ATP)
FX This research was funded by the American Water Works Association
Research Foundation (AwwaRF) and Texas Advanced Technology Research
Program (ATP), which the authors thank for their financial, technical,
and administrative assistance. The comments and views detailed herein
may not necessarily reflect the views of AwwaRF, its officers,
directors, affiliates, or agents. Any opinions expressed are those of
the authors and do not necessarily reflect the views of the U.S.
Environmental Protection Agency; therefore, no official endorsement
should be inferred. Any mention of trade names or commercial products
does not constitute endorsement or recommendation for use.
NR 39
TC 11
Z9 11
U1 1
U2 31
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0043-1354
J9 WATER RES
JI Water Res.
PD FEB
PY 2011
VL 45
IS 4
BP 1669
EP 1680
DI 10.1016/j.watres.2010.12.012
PG 12
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA 716SY
UT WOS:000286995000016
PM 21195446
ER
PT J
AU Garantziotis, S
AF Garantziotis, S.
TI Modulation of plasma complement by the initial dose of
epirubicin/docetaxel therapy in breast cancer and its predictive value
SO BRITISH JOURNAL OF CANCER
LA English
DT Letter
ID ALPHA-TRYPSIN INHIBITOR; PROTEINS
C1 [Garantziotis, S.] Natl Inst Environm Hlth Sci, Lab Resp Biol, Res Triangle Pk, NC 27709 USA.
[Garantziotis, S.] Univ N Carolina, Dept Med, Chapel Hill, NC USA.
RP Garantziotis, S (reprint author), Natl Inst Environm Hlth Sci, Lab Resp Biol, POB 12233,MD-CU01,111 TW Alexander Dr, Res Triangle Pk, NC 27709 USA.
EM garantziotis@niehs.nih.gov
RI Garantziotis, Stavros/A-6903-2009
OI Garantziotis, Stavros/0000-0003-4007-375X
NR 8
TC 1
Z9 1
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0007-0920
J9 BRIT J CANCER
JI Br. J. Cancer
PD FEB 1
PY 2011
VL 104
IS 3
BP 542
EP 542
DI 10.1038/sj.bjc.6606068
PG 1
WC Oncology
SC Oncology
GA 722IY
UT WOS:000287427100025
PM 21224852
ER
PT J
AU Vesper, S
AF Vesper, Stephen
TI Traditional mould analysis compared to a DNA-based method of mould
analysis
SO CRITICAL REVIEWS IN MICROBIOLOGY
LA English
DT Review
ID QUANTITATIVE PCR ANALYSIS; REAL-TIME PCR; POLYMERASE-CHAIN-REACTION;
RELATIVE MOLDINESS INDEX; STACHYBOTRYS-CHARTARUM; FUNGAL CONTAMINATION;
HOUSE-DUST; HOMES; INDOOR; ASPERGILLUS
AB Traditional environmental mould analysis is based on microscopic observations and counting of mould structures collected from the air on a sticky surface or culturing of moulds on growth media for identification and quantification. These approaches have significant limitations. A DNA-based method of mould analysis called mould specific quantitative PCR (MSQPCR) was created for more than 100 moulds. Based on a national sampling and analysis by MSQPCR of dust in US homes, a scale for comparing the mould burden in homes was created called the Environmental Relative Mouldiness Index (ERMI).90%. All influent samples were acutely toxic to Ceriodaphnia dubia and Pimephales promelas; toxicity was removed following treatment, except in the Luttrell Repository and Standard Mine BCR samples. Laboratory aeration of undiluted samples eliminated (Standard Mine BCR) or significantly reduced (Luttrell Repository, 65% survival) acute toxicity, most likely through removal of hydrogen sulfide. A toxicity identification evaluation suggested that metals also might be contributing to toxicity in the Luttrell Repository effluent samples; metals other than Mn were either not detected or very low (Fe and Pb) in the Standard Mine BCR samples. Field-aerated samples were not acutely toxic, and only the Luttrell Repository and Standard Mine samples showed short-term subchronic toxicity. Overall, results indicated BCR treatment had high metal removal efficiency and that inclusion of in-field aeration was beneficial in removal of acute and short-term subchronic toxicity. Environ. Toxicol. Chem. 2011;30:385-392. (C) 2010 SETAC
C1 [Smith, Mark E.; Lazorchak, James M.] US EPA, McConnell Grp, Cincinnati, OH 45268 USA.
RP Lazorchak, JM (reprint author), US EPA, McConnell Grp, Cincinnati, OH 45268 USA.
EM lazorchak.jim@epa.gov
OI Lazorchak, James/0000-0002-7354-7571
FU U.S. EPA Office of Research and Development's Engineering Technical
Support Center; McConnell Group, U.S. EPA [EP-D-06-096, EP-C-05-056]
FX The authors thank Mike Bishop for access to the Luttrell and PJK sites,
Jeff Schoenbacher for access to the Park City site, and Christina
Progess for access to the Standard Mine site. The authors thank the
McConnell Group, a U.S. EPA contractor, for toxicity testing (contract
EP-D-06-096); Pegasus, a contractor to the U.S. EPA, for ICP, sulfide,
and TOC analyses (contract EP-C-05-056); Larry Wetzel from U.S. EPA
NRMRL for conducting microwave digestions; and anonymous reviewers for
constructive comments. The U.S. EPA Office of Research and Development's
Engineering Technical Support Center funded the research described in
this paper. The manuscript was administratively reviewed and approved
for publication. Citations of product, company, or trade names do not
constitute endorsement by the U.S. EPA and are provided only for the
purpose of better describing information.
NR 26
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U1 3
U2 9
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0730-7268
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD FEB
PY 2011
VL 30
IS 2
BP 385
EP 392
DI 10.1002/etc.397
PG 8
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 710DB
UT WOS:000286490000016
PM 21072838
ER
PT J
AU Wehmas, LC
Cavallin, JE
Durhan, EJ
Kahl, MD
Martinovic, D
Mayasich, J
Tuominen, T
Villeneuve, DL
Ankley, GT
AF Wehmas, Leah C.
Cavallin, Jenna E.
Durhan, Elizabeth J.
Kahl, Michael D.
Martinovic, Dalma
Mayasich, Joe
Tuominen, Tim
Villeneuve, Daniel L.
Ankley, Gerald T.
TI SCREENING COMPLEX EFFLUENTS FOR ESTROGENIC ACTIVITY WITH THE T47D-KBLUC
CELL BIOASSAY: ASSAY OPTIMIZATION AND COMPARISON WITH IN VIVO RESPONSES
IN FISH
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Estrogens; Gene expression; Complex mixtures; Solid-phase extraction
ID WASTE-WATER; FATHEAD MINNOWS; PIMEPHALES-PROMELAS; SEWAGE EFFLUENT;
TREATMENT-PLANT; SURFACE-WATER; VITELLOGENIN; EXPRESSION; VITRO;
IDENTIFICATION
AB Wastewater treatment plant (WWTP) effluents can contain estrogenic chemicals, which potentially disrupt fish reproduction and development. The current study focused on the use of an estrogen-responsive in vitro cell bioassay (T47D-KBluc), to quantify total estrogenicity of WWTP effluents. We tested a novel sample preparation method for the T47D-KBluc assay, using powdered media prepared with direct effluent. Results of the T47D-KBluc assay were compared with the induction of estrogen receptor regulated gene transcription in male fathead minnows (Pimephales promelas) exposed to the same effluents. Effluent samples for the paired studies were collected over the course of three months. According to the T47D-KBluc assay, the effluent estrogenicity ranged from 1.13 to 2.00 ng 17 beta-estradiol (E2) equivalents/L. Corresponding in vivo studies exposing male fathead minnows to 0, 10, 50, and 100% effluent dilutions demonstrated that exposure to 100% effluent significantly increased hepatic vitellogenin (VTG) and estrogen receptor a subunit transcripts relative to controls. The induction was also significant in males exposed to 250 ng E2/L or 100 ng E2/L. The in vitro and in vivo results support the conclusion that the effluent contains significant estrogenic activity, but there was a discrepancy between in vitro and in vivo based E2 equivalent estimates. Our results suggest that the direct effluent preparation method for the T47D-KBluc assay is a reasonable approach to estimate the estrogenicity of wastewater effluent. Environ. Toxicol. Chem. 2011;30:439-445. (C) 2010 SETAC
C1 [Wehmas, Leah C.; Cavallin, Jenna E.; Durhan, Elizabeth J.; Kahl, Michael D.; Martinovic, Dalma; Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, Off Res & Dev, Duluth, MN 55804 USA.
[Martinovic, Dalma] Univ St Thomas, St Paul, MN USA.
[Mayasich, Joe; Tuominen, Tim] Western Lake Super Sanit Dist, Duluth, MN USA.
RP Cavallin, JE (reprint author), US EPA, Off Res & Dev, Duluth, MN 55804 USA.
EM cavallin.jenna@epa.gov
OI Martinovic-Weigelt, Dalma/0000-0002-9973-4965
NR 30
TC 13
Z9 13
U1 0
U2 21
PU SETAC PRESS
PI PENSACOLA
PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA
SN 0730-7268
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD FEB
PY 2011
VL 30
IS 2
BP 439
EP 445
DI 10.1002/etc.388
PG 7
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 710DB
UT WOS:000286490000021
PM 21038435
ER
PT J
AU Pfleeger, T
Olszyk, D
Lee, EH
Plocher, M
AF Pfleeger, Thomas
Olszyk, David
Lee, E. Henry
Plocher, Milton
TI COMPARING EFFECTS OF LOW LEVELS OF HERBICIDES ON GREENHOUSE- AND
FIELD-GROWN POTATOES (SOLANUM TUBEROSUM L.), SOYBEANS (GLYCINE MAX L.),
AND PEAS (PISUM SATIVUM L.)
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Phytotoxicity; Plant reproductive test; Toxicity endpoints;
Sulfometuron-methyl; Glyphosate
ID PESTICIDE REGISTRATION; SIMULATED DRIFT; SEED PRODUCTION; SULFONYLUREA;
PLANTS; CROP; CHLORSULFURON; REPRODUCTION; VARIABILITY; GUIDELINES
AB Although laboratory toxicology tests are generally easy to perform, cost effective, and readily interpreted, they have been questioned for their environmental relevance. In contrast, field tests are considered realistic while producing results that are difficult to interpret and expensive to obtain. Toxicology tests were conducted on potatoes, peas, and soybeans grown in a native soil in pots in the greenhouse and were compared to plants grown outside under natural environmental conditions to determine toxicological differences between environments, whether different plant developmental stages were more sensitive to herbicides, and whether these species were good candidates for plant reproductive tests. The reproductive and vegetative endpoints of the greenhouse plants and field-grown plants were also compared. The herbicides bromoxynil, glyphosate, MCPA ([4-chloro-2-methylphenoxy] acetic acid), and sulfometuron-methyl were applied at below field application rates to potato plants at two developmental stages. Peas and soybeans were exposed to sulfometuron-methyl at similar rates at three developmental stages. The effective herbicide concentrations producing a 25% reduction in a given measure differed between experimental conditions but were generally within a single order of magnitude within a species, even though there were differences in plant morphology. This study demonstrated that potatoes, peas, and soybeans grown in pots in a greenhouse produce phytotoxicity results similar to those grown outside in pots; that reproductive endpoints in many cases were more sensitive than vegetative ones; and that potato and pea plants are reasonable candidates for asexual and sexual reproductive phytotoxicity tests, respectively. Plants grown in pots in a greenhouse and outside varied little in toxicity. However, extrapolating those toxicity results to native plant communities in the field is basically unknown and in need of research. Environ. Toxicol. Chem. 2011;30:455-468. (C) 2010 SETAC
C1 [Pfleeger, Thomas; Olszyk, David; Lee, E. Henry] US EPA, Corvallis, OR USA.
[Plocher, Milton] Dynamac Corp, Corvallis, OR USA.
RP Pfleeger, T (reprint author), US EPA, Corvallis, OR USA.
EM Pfleeger.thomas@epa.gov
FU U.S. Environmental Protection Agency
FX The authors thank Alvin Mosley from Oregon State University. The authors
thank Elizabeth Davis and Henry Miller from the Senior Environmental
Employee Program of the National Asian Pacific Center on Aging; George
King, Fred Senecal, and Colleen Schowalter from Dynamic Corporation; and
Jee Lee and Conor Bidelspach, Oregon State University students. We also
thank Jeremy Clark and two anonymous reviewers. The information in this
document has been funded by the U.S. Environmental Protection Agency. It
has been subjected to review by the National Health and Environmental
Effects Research Laboratory's Western Ecology Division and approved for
publication. Approval does not signify that the contents reflect the
views of the Agency, nor does mention of trade names or commercial
products constitute endorsement or recommendation for use.
NR 33
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U1 4
U2 12
PU SETAC PRESS
PI PENSACOLA
PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA
SN 0730-7268
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD FEB
PY 2011
VL 30
IS 2
BP 455
EP 468
DI 10.1002/etc.394
PG 14
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 710DB
UT WOS:000286490000023
PM 21038430
ER
PT J
AU Bergfelt, DR
Steinetz, BG
Lasano, S
West, KL
Campbell, M
Adams, GP
AF Bergfelt, Don R.
Steinetz, Bernard G.
Lasano, Salamia
West, Kristi L.
Campbell, Michelle
Adams, Gregg P.
TI Relaxin and progesterone during pregnancy and the post-partum period in
association with live and stillborn calves in bottlenose dolphins
(Tursiops truncatus)
SO GENERAL AND COMPARATIVE ENDOCRINOLOGY
LA English
DT Article
DE Bottlenose dolphins; Pregnancy; Progesterone; Relaxin; Stillbirths
ID SERUM; RADIOIMMUNOASSAY; STILLBIRTH; DIAGNOSIS; PLACENTA; ABORTION;
MARKER; URINE; ROLES; CYCLE
AB The objectives of this study were to validate a relaxin and progesterone RIA for use in bottlenose dolphins, and quantify and characterize both hormones in extracts of placental tissue and serum collected during pregnancy and the post-partum period, and compare the results between dolphins with live and stillborn calves. In Experiment 1, validation of a heterologous relaxin and progesterone RIA involved specific displacement of antibody-bound radiolabeled human relaxin or progesterone in response to increasing volumes of pooled pregnant dolphin serum and amounts of respective hormone standards added to a fixed volume of serum. The displacement curves were considered parallel and additive relative to respective standard curves. In Experiment 2, immunoreactive relaxin and progesterone were detected in placental extracts and, in corresponding serum samples, concentrations of both hormones were higher during the pre-partum than post-partum periods. Circulatory concentrations of progesterone decreased (P < 0.05) from relatively high concentrations during early and mid-pregnancy to intermediate concentrations by late pregnancy (month effect, P < 0.0001) in dolphins with live births, whereas, in dolphins with stillbirths, the decrease in progesterone began earlier (month-by-birth status interaction, P < 0.007); mean concentrations were lower at mid- (37%, P < 0.06) and late (25%) pregnancy. Temporally, relaxin increased (P < 0.05) progressively from relatively low concentrations during early pregnancy to high concentrations during late pregnancy (month effect, P < 0.0001) and was not different between birth statuses (birth status effect. P = 0.76; month-by-birth status interaction, P = 0.17). Even though the interaction did not reach significance, mean relaxin concentrations were 42%, 29%, and 34% lower at early, mid-, and late pregnancy, respectively, in dolphins with stillbirths than in those with live births. In conclusion, the pregnancy-specific increase in serum concentrations of relaxin and lower concentrations of both relaxin and progesterone in association with stillbirths suggest the potential for relaxin to be used diagnostically to determine pregnancy status, and one or both hormones to be used to assess placental function, and, perhaps, fetal well-being in bottlenose dolphins and other cetaceans. Published by Elsevier Inc.
C1 [Bergfelt, Don R.] US EPA, Washington, DC 20460 USA.
[Steinetz, Bernard G.; Lasano, Salamia] NYU, Sch Med, Tuxedo Pk, NY 10987 USA.
[West, Kristi L.] Hawaii Pacific Univ, Kaneohe, HI 96744 USA.
[Campbell, Michelle] Dolphin Quest & Quest Global Management, Waikoloa, HI 96738 USA.
[Adams, Gregg P.] Univ Saskatchewan, Saskatoon, SK S7N 5B4, Canada.
RP Bergfelt, DR (reprint author), US EPA, Washington, DC 20460 USA.
EM bergfelt.don@epa.gov
FU National Marine Mammal Laboratory; NYU NIEHS Center [ES00260]
FX This study was supported by grants from the National Marine Mammal
Laboratory and NYU NIEHS Center (ES00260). Dolphin serum samples and
placentas were provided by Dolphin Quest and the Indianapolis Zoo. The
authors thank Drs. Jay Sweeney, Rae Stone, Gregg Levine, and the Dolphin
Quest training staff who manage the Dolphin Quest Reproduction Program.
In addition, the authors thank Drs. Todd Robeck for providing
supplementary reference material on reproduction in cetaceans and Mohd
Beg for assistance with statistical analyses.
NR 46
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U1 1
U2 10
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0016-6480
J9 GEN COMP ENDOCR
JI Gen. Comp. Endocrinol.
PD FEB 1
PY 2011
VL 170
IS 3
BP 650
EP 656
DI 10.1016/j.ygcen.2010.12.002
PG 7
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 712EK
UT WOS:000286647300030
PM 21156178
ER
PT J
AU Griffin, SM
Chen, IM
Fout, GS
Wade, TJ
Egorov, AI
AF Griffin, Shannon M.
Chen, Ing M.
Fout, G. Shay
Wade, Timothy J.
Egorov, Andrey I.
TI Development of a multiplex microsphere immunoassay for the quantitation
of salivary antibody responses to selected waterborne pathogens
SO JOURNAL OF IMMUNOLOGICAL METHODS
LA English
DT Article
DE Luminex immunoassay; Salivary antibody; Waterborne; Helicobacter pylori;
Toxoplasma gondii; Noroviruses; Cryptosporidium
ID NORWALK VIRUS-INFECTION; ORAL-FLUID COLLECTION; HELICOBACTER-PYLORI
INFECTION; IMMUNOGLOBULIN-G ANTIBODIES; SECRETORY IGA ANTIBODIES;
COAST-GUARD CUTTER; DRINKING-WATER; UNITED-STATES;
CRYPTOSPORIDIUM-PARVUM; ENZYME-IMMUNOASSAY
AB Saliva has an important advantage over serum as a medium for antibody detection due to noninvasive sampling, which is critical for community-based epidemiological surveys. The development of a Luminex multiplex immunoassay for measurement of salivary IgG and IgA responses to potentially waterborne pathogens, Helicobacter pylori, Toxoplasma gondii, Cryptosporidium, and four noroviruses, involved selection of antigens and optimization of antigen coupling to Luminex microspheres. Coupling confirmation was conducted using antigen specific antibody or control sera at serial dilutions. Dose response curves corresponding to different coupling conditions were compared using statistical tests. Control proteins in the specific antibody assay and a separate duplex assay for total immunoglobulins G and A were employed to assess antibody cross-reactivity and variability in saliva composition. 200 saliva samples prospectively collected from 20 adult volunteers and 10 paired sera from a subset of these volunteers were used to test this method. For chronic infections, H. pylori and T. gondii, individuals who tested IgG seropositive using commercial diagnostic ELISA also had the strongest salivary antibody responses in salivary antibody tests. A steep increase in antinorovirus salivary antibody response (immunoconversion) was observed after an episode of acute diarrhea and vomiting in a volunteer. The Luminex assay also detected seroconversions to Cryptosporidium using control sera from infected children. Ongoing efforts involve further verification of salivary antibody tests and their application in larger pilot community studies. Published by Elsevier B.V.
C1 [Wade, Timothy J.; Egorov, Andrey I.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Griffin, Shannon M.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA.
[Griffin, Shannon M.; Fout, G. Shay] US EPA, Natl Exposure Res Lab, Cincinnati, OH USA.
RP Egorov, AI (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, 109 TW Alexander Dr,MD 58C, Res Triangle Pk, NC 27711 USA.
EM andegorov@gmail.com
FU U.S. Department of Energy; USEPA
FX Shannon Griffin was supported through an appointment to the Research
Participation Program at the U.S. Environmental Protection Agency
administered by the Oak Ridge Institute for Science and Education
through an interagency agreement between the U.S. Department of Energy
and USEPA. The authors are grateful to Drs. Jeffrey Priest, Jan Vinje,
Harry Kleanthous, Honorine Ward, Xi Jiang, and Alec Sutherland for
kindly providing proteins, antibodies, or control sera for this study,
and Eric Rhodes, Jeffrey Swartout, and Swinburne Augustine for critical
review of this manuscript. Although this work was reviewed by USEPA and
approved for publication, it represents views of its authors and does
not reflect official Agency policy. The mention of trade names or
commercial products does not constitute endorsement or recommendation
for use.
NR 49
TC 19
Z9 19
U1 0
U2 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1759
J9 J IMMUNOL METHODS
JI J. Immunol. Methods
PD FEB 1
PY 2011
VL 364
IS 1-2
BP 83
EP 93
DI 10.1016/j.jim.2010.11.005
PG 11
WC Biochemical Research Methods; Immunology
SC Biochemistry & Molecular Biology; Immunology
GA 717QO
UT WOS:000287062700009
PM 21093445
ER
PT J
AU Heberling, MT
AF Heberling, Matthew T.
TI Issues in Water Quality Trading: Introduction to Featured Collection
SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION
LA English
DT Editorial Material
ID NONPOINT POLLUTION-CONTROL; PROGRAMS
C1 US EPA, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA.
RP Heberling, MT (reprint author), US EPA, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA.
EM heberling.matt@epa.gov
OI Heberling, Matthew/0000-0003-1120-612X
NR 30
TC 2
Z9 2
U1 0
U2 4
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1093-474X
J9 J AM WATER RESOUR AS
JI J. Am. Water Resour. Assoc.
PD FEB
PY 2011
VL 47
IS 1
BP 1
EP 4
DI 10.1111/j.1752-1688.2010.00510.x
PG 4
WC Engineering, Environmental; Geosciences, Multidisciplinary; Water
Resources
SC Engineering; Geology; Water Resources
GA 711ZA
UT WOS:000286629700001
ER
PT J
AU Sidle, WC
Cvetic, V
AF Sidle, W. C.
Cvetic, V.
TI Stable water isotope climate archives in springs from the Olympic
Mountains, Washington
SO ENVIRONMENTAL EARTH SCIENCES
LA English
DT Article
DE Stable isotope; Spring; Holocene climate change; Olympic Mountains
ID SUBDUCTION COMPLEX; NORTH-AMERICA; TREE-RINGS; GROUNDWATER;
PRECIPITATION; HYDROGEN; MODELS; SIMULATIONS; HYDROLOGY; DEUTERIUM
AB The (18)O and (2)H (HDO) compositions are summarized for sampled springs (n = 81) within the Elwha watershed (a parts per thousand 692 km(2)) on the northern Olympic Peninsula. Samples, collected during 2001-2009, of springs (n = 158), precipitation (n = 520), streams (n = 176), and firn (n = 3) assisted the determinations for meteoric composition of recharge waters. The local mean water line (LMWL) is defined as delta(2)H = 8.2 delta(18)O - 9.3 for the watershed. Recharge history is surmised from groundwater ages ranging from 5 +/- A 3 years (apparent (85)Kr) to 9,490 +/- A 420 (14)C cal years BP. About 56% of the springs were recharged over the last 1,000 years while 13% of springs were recharged over 5,000 years ago. Spring HDO values fluctuate between -11.8 to -15.6aEuro degrees delta(18)O and -90.9 to -119.4aEuro degrees delta(2)H. Deuterium excess values predominate around 4-6aEuro degrees. The HDO proxy records from springs suggest a pronounced paleoclimate shift in air masses near 5,000 year BP on the Peninsula.
C1 [Sidle, W. C.] US EPA, Natl Risk Management Res Lab, Water Supply & Water Resources Div, Cincinnati, OH 45268 USA.
[Cvetic, V.] Groundwater Res Co, Port Angeles, WA 98363 USA.
RP Sidle, WC (reprint author), US EPA, Natl Risk Management Res Lab, Water Supply & Water Resources Div, Cincinnati, OH 45268 USA.
EM sidle.william@epa.gov
NR 60
TC 1
Z9 1
U1 1
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1866-6280
J9 ENVIRON EARTH SCI
JI Environ. Earth Sci.
PD FEB
PY 2011
VL 62
IS 3
BP 569
EP 580
DI 10.1007/s12665-010-0548-9
PG 12
WC Environmental Sciences; Geosciences, Multidisciplinary; Water Resources
SC Environmental Sciences & Ecology; Geology; Water Resources
GA 706CE
UT WOS:000286193200010
ER
PT J
AU Farraj, AK
Hazari, MS
Haykal-Coates, N
Lamb, C
Winsett, DW
Ge, Y
Ledbetter, AD
Carll, AP
Bruno, M
Ghio, A
Costa, DL
AF Farraj, Aimen K.
Hazari, Mehdi S.
Haykal-Coates, Najwa
Lamb, Christina
Winsett, Darrell W.
Ge, Yue
Ledbetter, Allen D.
Carll, Alex P.
Bruno, Maribel
Ghio, Andy
Costa, Daniel L.
TI ST Depression, Arrhythmia, Vagal Dominance, and Reduced Cardiac
Micro-RNA in Particulate-Exposed Rats
SO AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
LA English
DT Article
DE air pollution; arrhythmia; autonomic nervous system; cardiac microRNA;
pulmonary toxicity
ID HEART-RATE-VARIABILITY; OIL FLY-ASH; GASEOUS AIR-POLLUTION;
MYOCARDIAL-INFARCTION; AMBIENT AIR; ULTRAFINE PARTICLES; SEGMENT
DEPRESSION; HYPERTENSIVE-RATS; FINE PARTICULATE; HEALTHY-CHILDREN
AB Recently, investigators demonstrated associations between fine particulate matter (PM)-associated metals and adverse health effects. Residual oil fly ash (ROFA), a waste product of fossil fuel combustion from boilers, is rich in the transition metals Fe, Ni, and V, and when released as a fugitive particle, is an important contributor to ambient fine particulate air pollution. We hypothesized that a single-inhalation exposure to transition metal-rich PM will cause concentration-dependent cardiovascular toxicity in spontaneously hypertensive (SH) rats. Rats implanted with telemeters to monitor heart rate and electrocardiogram were exposed once by nose-only inhalation for 4 hours to 3.5 mg/m(3), 1.0 mg/m(3), or 0.45 mg/m(3) of a synthetic PM (dried salt solution), similar in composition to a well-studied ROFA sample consisting of Fe, Ni, and V. Exposure to the highest concentration of PM decreased T-wave amplitude and area, caused ST depression, reduced heart rate (HR), and increased non-conducted P-wave arrhythmias. These changes were accompanied by increased pulmonary inflammation, lung resistance, and vagal tone, as indicated by changes in markers of HR variability (increased root of the mean of squared differences of adjacent RR intervals [RMSSD], low frequency [LF], high frequency [HF], and decreased LF/HF), and attenuated myocardial micro-RNA (RNA segments that suppress translation by targeting messenger RNA) expression. The low and intermediate concentrations of PM had less effect on the inflammatory, HR variability, and micro-RNA endpoints, but still caused significant reductions in HR. In addition, the intermediate concentration caused ST depression and increased QRS area, whereas the low concentration increased the T-wave parameters. Thus, PM-induced cardiac dysfunction is mediated by multiple mechanisms that may be dependent on PM concentration and myocardial vulnerability (this abstract does not reflect the policy of the United States Environmental Protection Agency).
C1 [Farraj, Aimen K.; Hazari, Mehdi S.; Winsett, Darrell W.; Ledbetter, Allen D.; Ghio, Andy] US EPA, Environm Publ Hlth Div, Res Triangle Pk, NC 27711 USA.
[Haykal-Coates, Najwa] US EPA, Biostat & Bioinformat Res Core Unit, Res Triangle Pk, NC 27711 USA.
[Carll, Alex P.] US EPA, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Lamb, Christina; Bruno, Maribel] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Ge, Yue] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC USA.
[Costa, Daniel L.] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC USA.
RP Farraj, AK (reprint author), US EPA, Environm Publ Hlth Div, Mail Code B143-01, Res Triangle Pk, NC 27711 USA.
EM farraj.aimen@epa.gov
OI Carll, Alex/0000-0003-1832-3070
FU University of North Carolina at Chapel Hill; United States Environmental
Protection Agency [EPA CR83323601]
FX C.L. was funded by a Biological and Biomedical Sciences Program Training
Grant from the University of North Carolina at Chapel Hill. A. P. C. was
supported by grant EPA CR83323601 from the United States Environmental
Protection Agency and the University of North Carolina at Chapel Hill.
NR 71
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U1 0
U2 13
PU AMER THORACIC SOC
PI NEW YORK
PA 61 BROADWAY, FL 4, NEW YORK, NY 10006 USA
SN 1044-1549
J9 AM J RESP CELL MOL
JI Am. J. Respir. Cell Mol. Biol.
PD FEB
PY 2011
VL 44
IS 2
BP 185
EP 196
DI 10.1165/rcmb.2009-0456OC
PG 12
WC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
SC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
GA 753KJ
UT WOS:000289771700007
PM 20378750
ER
PT J
AU Butler, TJ
Vermeylen, FM
Rury, M
Likens, GE
Lee, B
Bowker, GE
McCluney, L
AF Butler, Thomas J.
Vermeylen, Francoise M.
Rury, Melissa
Likens, Gene E.
Lee, Brian
Bowker, George E.
McCluney, Lance
TI Response of ozone and nitrate to stationary source NOx emission
reductions in the eastern USA
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Ozone trends; Nitrate trends; NOx emissions; Random coefficient models;
Nitrogen Budget trading program; NBP
ID GROUND-LEVEL OZONE; AIR ACT AMENDMENTS; UNITED-STATES; NITROGEN
DEPOSITION; BACKGROUND OZONE; URBAN AREAS; PHASE-I; TRENDS; IMPACT;
HYDROCARBONS
AB This study is an assessment of the impact of reduced stationary source NOx emissions on ground-level concentrations of ozone (O-3) and dry-NO3 (HNO3(g) + NO3(p)-) in the eastern United States (EUS). Total anthropogenic NOx and VOC emissions have declined 32% and 20%, respectively, from 1997 to 2005 in the 20 eastern states participating in a NOx Budget Trading Program (NBP). Annual and ozone season (OS) NOx emissions from electric generating units (EGUs) have declined 48% and 66%, respectively, in the EUS.
From 1997-1999 to 2006-2008 measured decline in meteorologically adjusted (met-adj) daily maximum 8-h (dm8h) O-3, has been 8 ppb or 14% for the EUS during the May-September OS, with the largest declines occurring in the highest concentration category (99th percentile). Random coefficient models, with NBP and Acid Rain Program (ARP) regulated NOx emissions as the independent variable, show highly significant relations (p <= 0.0001) to dm8h O-3 for 1997-2008 during the OS. Regional declines within the EUS range from 11% to 16%. The patterns of the O-3 trends are in general agreement with other recent studies. Rural and urban sites both show similar levels of decline from pre- to post-NBP periods.
Dry-NO3 during the OS shows a substantial decline from 3.1 to 1.8 mu g NO3 m(-3). Random coefficient models show regional results ranging from 32% to 39% declines, and measured results show a 35-46% decline in dry-NO3 from 1997-1999 to 2006-2008. These results suggest that regulating NOx emissions has been highly effective in reducing both ozone and dry-NO3 concentrations during the OS.
Overall, a 32% reduction in total annual anthropogenic NOx emissions from 1997 to 2005 has been accompanied by a 7-8 ppb, or 12-13% decline in OS dm8h O-3 concentration, and a 34% decline in dry-NO3 concentration in the 20-state NBP region. Model results indicate a 50% further reduction in NBP regulated NOx emissions will reduce O-3 concentrations an additional 3-5% and dry-NO3 concentrations by 13-16%. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Butler, Thomas J.; Vermeylen, Francoise M.] Cornell Univ, Stat Consulting Unit, Ithaca, NY 14853 USA.
[Butler, Thomas J.; Likens, Gene E.] Cary Inst Ecosyst Studies, Millbrook, NY USA.
[Rury, Melissa; Lee, Brian; Bowker, George E.; McCluney, Lance] US EPA, Off Air & Radiat, Off Atmospher Programs, Washington, DC 20460 USA.
RP Butler, TJ (reprint author), Cornell Univ, Stat Consulting Unit, 211 Rice Hall, Ithaca, NY 14853 USA.
EM TJB2@cornell.edu
RI Pfister, Gabriele/A-9349-2008
FU USEPA Clean Air Markets Division; NOAA Air Resources Lab
FX We would like to thank Joseph Sickles III (USEPA Office of Research and
Development), Gary Lear (USEPA Clean Air Markets Division) and three
anonymous reviewers for constructive criticism of the manuscript, and
Thomas McMullen (USEPA Emission Factor And Inventory Group) for
assistance in obtaining the NO emission data. We would also like to
acknowledge the USEPA Clean Air Markets Division and the NOAA Air
Resources Lab for sponsoring part of this study.
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD FEB
PY 2011
VL 45
IS 5
BP 1084
EP 1094
DI 10.1016/j.atmosenv.2010.11.040
PG 11
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 725BF
UT WOS:000287619500003
ER
PT J
AU Zheng, M
Wang, F
Hagler, GSW
Hou, XM
Bergin, M
Cheng, YA
Salmon, LG
Schauer, JJ
Louie, PKK
Zeng, LM
Zhang, YH
AF Zheng, Mei
Wang, Fu
Hagler, G. S. W.
Hou, Ximei
Bergin, Michael
Cheng, Yuan
Salmon, L. G.
Schauer, James J.
Louie, Peter K. K.
Zeng, Limin
Zhang, Yuanhang
TI Sources of excess urban carbonaceous aerosol in the Pearl River Delta
Region, China
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Organic carbon; Source apportionment; Molecular markers; Chemical mass
balance; The Pearl River Delta
ID EXTRACTABLE ORGANIC-COMPOUNDS; PARTICULATE AIR-POLLUTION; SOURCE
APPORTIONMENT; HONG-KONG; PRD REGION; PM2.5; TRACERS; MATTER;
PRIDE-PRD2004; QUALITY
AB Carbonaceous aerosol is one of the important constituents of fine particulate matter (PM(2.5)) in southern China, including the Pearl River Delta (PRD) region and Hong Kong (HK). During the study period (October and December of 2002, and March and June of 2003), the monthly average organic carbon (OC) ranged from 3.52 to 7.87 mu g m(-3) in Hong Kong and 4.14-20.19 mu g m(-3) in the PRD from simultaneous measurements at three sites in HK and four sites in the PRO. Compared to the PRD, the spatial distribution of carbonaceous aerosol in Hong Kong was relatively homogeneous. Sources contributing to excess OC in the PRO were examined, which is the difference between OC concentrations measured at the PRD sites to the average level in Hong Kong. Eight primary sources contributing to excess OC were identified with chemical mass balance modeling in a combination with molecular markers analyzed by gas chromatography/mass spectrometry. Excess OC at Guangzhou, the capital city of Guangdong province, was consistently high, ranging from 9.77 to 13.6 mu g m(-3). Four primary sources including gasoline engine exhaust, diesel engine exhaust, biomass burning, and coal combustion accounted for more than 50% of excess OC in the PRD, especially in December (up to 76%). Mobile source emissions alone can contribute about 30% of excess OC. The unexplained or other excess OC was the highest at the rural site, but in general less than 20% at other sites. The coal combustion source contribution was unique in that it exhibited relatively homogeneous spatial distribution, indicating it was still an important source of carbonaceous aerosol in the PRO (17% of excess OC) during the study period. This analysis revealed that primary emissions are important sources of excess OC in the PRD and there is a need to reduce the emissions of mobile sources, biomass burning, and coal combustion in order to improve air quality in southern China. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Zeng, Limin; Zhang, Yuanhang] Peking Univ, Coll Environm Sci & Engn, Beijing 100871, Peoples R China.
[Zheng, Mei; Wang, Fu; Hou, Ximei; Bergin, Michael; Cheng, Yuan] Georgia Inst Technol, Sch Earth & Atmospher Sci, Atlanta, GA 30332 USA.
[Hagler, G. S. W.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
[Bergin, Michael] Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30332 USA.
[Salmon, L. G.] CALTECH, Environm Qual Lab, Pasadena, CA 91125 USA.
[Schauer, James J.] Univ Wisconsin, Madison, WI 53706 USA.
[Louie, Peter K. K.] Environm Protect Dept, Hong Kong, Hong Kong, Peoples R China.
RP Zhang, YH (reprint author), Peking Univ, Coll Environm Sci & Engn, Beijing 100871, Peoples R China.
EM yhzhang@pku.edu.cn
RI Zhang, Yuanhang/F-7038-2011; hui, wanghui/C-5671-2008; Cheng,
Yuan/E-2508-2011; Zeng, Limin/D-3948-2013
OI Cheng, Yuan/0000-0002-2077-5335;
FU Hong Kong Jockey Club Charities Trust; Castle Peak Power Co. Ltd.;
Environmental Protection Department of the Hong Kong Special
Administrative Region; Shell Hong Kong Ltd., through Civic Exchange
FX This research was sponsored by Hong Kong Jockey Club Charities Trust,
Castle Peak Power Co. Ltd., the Environmental Protection Department of
the Hong Kong Special Administrative Region, the Shell Hong Kong Ltd.,
through Civic Exchange. We thank Christine Loh, the founder of Civic
Exchange, and C.S. Kiang for coordinating the project, Dr. Tao Wang of
Hong Kong Polytechnic University for the project assistance throughout
this study, and Tao Liu of the Guangzhou Environmental Monitoring
Center, Jianjun Chen of the Conghua Environmental Monitoring Center, and
Wendong Yang of the Zhongshan Environmental Monitoring Center for their
assistance in sampling coordination. We thank two anonymous referees for
their valuable comments and constructive suggestions to the manuscript.
While one of the coauthors, G. Hagler, is currently identified as an
U.S. Environmental Protection Agency (USEPA) employee, the data were
collected while she was a doctoral student at the Georgia Institute of
Technology. This article has been subjected to the USEPA and HKEPD
technical and administrative review process and approved for
publication. The content of this paper does not necessarily reflect the
views or policies of any governments, including USEPA, the Governments
of Guangdong and the Hong Kong Special Administrative Region, nor does
any mention of trade names or commercial products constitute an
endorsement or recommendation of their use.
NR 28
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD FEB
PY 2011
VL 45
IS 5
BP 1175
EP 1182
DI 10.1016/j.atmosenv.2010.09.041
PG 8
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 725BF
UT WOS:000287619500014
ER
PT J
AU Beyer, BK
Chernoff, N
Danielsson, BR
Davis-Bruno, K
Harrouk, W
Hood, RD
Janer, G
Liminga, UW
Kim, JH
Rocca, M
Rogers, J
Scialli, AR
AF Beyer, Bruce K.
Chernoff, Neil
Danielsson, Bengt R.
Davis-Bruno, Karen
Harrouk, Wafa
Hood, Ronald D.
Janer, Gemma
Liminga, Ulla Wandel
Kim, James H.
Rocca, Meredith
Rogers, John
Scialli, Anthony R.
TI ILSI/HESI Maternal Toxicity Workshop Summary: Maternal Toxicity and Its
Impact on Study Design and Data Interpretation
SO BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY
LA English
DT Article
DE maternal-fetal interactions; mechanisms of teratogenesis;
pharmaceuticals; safety assessment; developmental toxicity; maternal
toxicity; prenatal; teratology
ID ANTIARRHYTHMIC AGENT ALMOKALANT; EMBRYONIC CARDIAC-ARRHYTHMIA;
UTEROPLACENTAL BLOOD-FLOW; DEVELOPMENTAL TOXICITY; FETAL DEVELOPMENT;
RHYTHM ABNORMALITIES; INTRAUTERINE GROWTH; BLOCKING ACTIVITY; FOOD
RESTRICTION; DIGITAL DEFECTS
AB Workshops on maternal toxicity were held at the annual Society of Toxicology, Teratology Society, and European Teratology Society meetings in 2009. Speakers presented background information prior to a general discussion on this topic.
The following recommendations/options are based on the outcome of the discussions at the workshops:
1. A comprehensive evaluation of all available data from general toxicity studies, range-finding Developmental and Reproductive Toxicology (DART) studies, class effects, structure-activity relationships, exposure studies, etc. is essential for appropriate dose selection for definitive DART studies. The intent is to avoid marked maternal toxicity leading to mortality or decreased body weight gains of greater than 20% for prolonged periods.
(a) Evaluate alternative endpoints for dose selection and data interpretation (e.g., target tissue effects and pharmacology) for biotherapeutics.
(b) Evaluate additional maternal parameters based on effects and/or target organs observed in short-term (e.g., 2- or 4-week) general toxicity studies. 2. Evaluate all available data to determine a cause-effect relationship for developmental toxicity.
(a) Conduct a pair-feeding/pair-watering study as a follow-up.
(b) Evaluate individual data demonstrating maternal toxicity in the mother with adverse embryo-fetal outcomes in the litter associated with the affected mother.
(c) Conduct single-dose studies at increasing doses as a complement to conventional embryo-fetal toxicity studies for certain classes of compounds that affect the hERG channel. 3. Support statements that embryo-fetal effects are caused by maternal toxicity and/or exaggerated pharmacology, especially for malformations.
(a) Provide mechanistic or other supporting data.
(b) Establish the relevance of the DART findings in animals for human exposures. Birth Defects Res (Part B) 92:36-51, 2011. (C) 2010 Wiley-Liss, Inc.
C1 [Beyer, Bruce K.] Sanofi Aventis US Inc, Disposit Safety & Anim Res Preclin Safety, Dept Disposit Safety & Anim Res Preclin Safety, Bridgewater, NJ 08807 USA.
[Chernoff, Neil; Rogers, John] US EPA, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Danielsson, Bengt R.] Pharmanet Dev Grp, Consultancy Div, Stockholm, Sweden.
[Danielsson, Bengt R.] Uppsala Univ, Dept Pharmaceut Biosci, Uppsala, Sweden.
[Davis-Bruno, Karen; Harrouk, Wafa] US FDA, CDER OND, Silver Spring, MD USA.
[Hood, Ronald D.] Univ Alabama, Dept Biol Sci, Tuscaloosa, AL USA.
[Hood, Ronald D.] Ronald D Hood & Associates, Toxicol Consultants, Tuscaloosa, AL USA.
[Janer, Gemma] Palau Pharma SA, Dept Pharmacol & Toxicol, Palau de Plegamans, Spain.
[Liminga, Ulla Wandel] Med Prod Agcy, Sci & Regulatory Strategy, Uppsala, Sweden.
[Kim, James H.] ILSI Hlth & Environm Sci Inst, Washington, DC USA.
[Rocca, Meredith] Elan Pharmaceut, Dept Nonclin Safety Evaluat, San Francisco, CA USA.
[Scialli, Anthony R.] Tetra Tech Sci, Washington, DC USA.
RP Beyer, BK (reprint author), Sanofi Aventis US Inc, Disposit Safety & Anim Res Preclin Safety, Dept Disposit Safety & Anim Res Preclin Safety, Mail Stop JR2-103B,1041 Route 202-206,POB 6800, Bridgewater, NJ 08807 USA.
EM bruce.beyer@sanofi-aventis.com
FU Health and Environmental Sciences Institute (HESI)
FX Grant sponsor: Health and Environmental Sciences Institute (HESI).
NR 72
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U1 2
U2 5
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1542-9733
J9 BIRTH DEFECTS RES B
JI Birth Defects Res. Part B-Dev. Reprod. Toxicol.
PD FEB
PY 2011
VL 92
IS 1
BP 36
EP 51
DI 10.1002/bdrb.20281
PG 16
WC Oncology; Genetics & Heredity; Toxicology
SC Oncology; Genetics & Heredity; Toxicology
GA 729XF
UT WOS:000287986900004
PM 21312321
ER
PT J
AU Oliveira, T
Santacroce, G
Coleates, R
Hale, S
Zevin, P
Belasco, B
AF Oliveira, Tiago
Santacroce, Gregory
Coleates, Richard
Hale, Stephen
Zevin, Paula
Belasco, Barbara
TI Concentrations of polychlorinated biphenyls in water from US Lake
Ontario tributaries between 2004 and 2008
SO CHEMOSPHERE
LA English
DT Article
DE Polychlorinated biphenyls; HRGC/HRMS; Lake Ontario; Tributaries
ID LAURENTIAN GREAT-LAKES; ORGANOCHLORINE PESTICIDES; DETROIT RIVER; PCBS;
SEDIMENT; MICHIGAN; EXCHANGE; CONTAMINATION; COLUMN; BIOTA
AB Research on the environmental fate and transport of PCBs in Lake Ontario basin depends, among other aspects, on the availability of representative data sets for upstream sources, but data are lacking for most US Lake Ontario tributaries. In this study, water samples were collected between September 2004 and October 2008 from five tributaries and were analyzed for 209 polychlorinated biphenyls (PCB) with high-resolution gas chromatography/high resolution mass spectrometry (HRGC/HRMS) following EPA Method 1668A. Total PCB concentrations ranged between 0.31 and 42.75 ng L(-1). Congeners between Di and Hexa PCBs accounted between 70 and 99% of the total PCB. The tributary with highest PCB concentrations presented similar pattern and percentage levels to Aroclor 1242. Total average loads for the sampling events ranged between 1.85 g d(-1) and 59.08 g d(-1). PCB concentrations were evaluated against other variables and other studies (including different matrices) to better understand their transport. The methodology used is reliable to assess PCB contamination in surface water. Published by Elsevier Ltd.
C1 [Oliveira, Tiago; Santacroce, Gregory; Coleates, Richard; Hale, Stephen; Zevin, Paula] US EPA, Div Environm Sci & Assessment, Edison, NJ 08837 USA.
[Belasco, Barbara] US EPA, Div Environm Planning & Protect, New York, NY 10007 USA.
RP Oliveira, T (reprint author), US EPA, Div Environm Sci & Assessment, Reg 2,2890 Woodbridge Ave, Edison, NJ 08837 USA.
EM Oliveira.Tiago@epa.gov
RI S Oliveira, Tiago/M-7913-2014
OI S Oliveira, Tiago/0000-0002-0777-0484
NR 27
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Z9 9
U1 0
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
J9 CHEMOSPHERE
JI Chemosphere
PD FEB
PY 2011
VL 82
IS 9
BP 1314
EP 1320
DI 10.1016/j.chemosphere.2010.12.012
PG 7
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 724GD
UT WOS:000287563200014
PM 21186045
ER
PT J
AU Sikdar, SK
AF Sikdar, Subhas K.
TI What about industrial water sustainability?
SO CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY
LA English
DT Editorial Material
C1 US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Sikdar, SK (reprint author), US EPA, Natl Risk Management Res Lab, 26 W ML King Dr, Cincinnati, OH 45268 USA.
EM sikdar.subhas@epa.gov
NR 0
TC 4
Z9 4
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1618-954X
J9 CLEAN TECHNOL ENVIR
JI Clean Technol. Environ. Policy
PD FEB
PY 2011
VL 13
IS 1
BP 1
EP 1
DI 10.1007/s10098-010-0342-0
PG 1
WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental;
Environmental Sciences
SC Science & Technology - Other Topics; Engineering; Environmental Sciences
& Ecology
GA 709TJ
UT WOS:000286464000001
ER
PT J
AU Ward, EJ
Semmens, BX
Phillips, DL
Moore, JW
Bouwes, N
AF Ward, Eric J.
Semmens, Brice X.
Phillips, Donald L.
Moore, Jonathan W.
Bouwes, Nicolaas
TI A quantitative approach to combine sources in stable isotope mixing
models
SO ECOSPHERE
LA English
DT Article
DE Bayesian analysis; diet; mixing model; source partitioning; stable
isotope
AB Stable isotope mixing models, used to estimate source contributions to a mixture, typically yield highly uncertain estimates when there are many sources and relatively few isotope elements. Previously, ecologists have either accepted the uncertain contribution estimates for individual sources or addressed the problem in an ad hoc way by combining either related sources prior to analysis or the estimated proportions of related sources following analysis. Neither of these latter approaches explicitly account for uncertainty in source combinations within the likelihood framework. In this paper we incorporate uncertainty in both the number of source groups and group assignment within a formal Bayesian mixing model framework. By dynamically exploring model complexity due to aggregating sources based on shared proportional contributions, we can estimate posterior probabilities of alternative group configurations, and construct posterior dendrograms of group membership. We apply this method to simulated data, and illustrate applications to two consumer datasets (rainbow trout, coastal mink). Our results demonstrate that estimating, rather than fixing, the number of proportional contributions in a mixing model can improve model inference and reduce bias in estimates of source contributions to a mixture.
C1 [Ward, Eric J.; Semmens, Brice X.] NOAA, Natl Marine Fisheries Serv, Seattle, WA 98112 USA.
[Phillips, Donald L.] US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA.
[Moore, Jonathan W.] Univ Calif Santa Cruz, Dept Ecol & Evolutionary Biol, Santa Cruz, CA 95060 USA.
[Bouwes, Nicolaas] Eco Log Res Inc, Providence, UT 84332 USA.
RP Ward, EJ (reprint author), NOAA, Natl Marine Fisheries Serv, Seattle, WA 98112 USA.
EM eric.ward@noaa.gov
FU Bonneville Power Administration
FX We thank J. Yeakel for criticism that helped improve this manuscript.
Nicholas Weber collected, processed, and compiled the ISEMP data used in
this manuscript. E. J. Ward and B. X. Semmens contributed equally to
this manuscript. Funding for ISEMP was provided by the Bonneville Power
Administration. This document has been subjected to the U.S.
Environmental Protection Agency's peer and administrative review, and it
has been approved for publication as an EPA document. Mention of trade
names or commercial products does not constitute endorsement or
recommendation for use.
NR 16
TC 11
Z9 11
U1 3
U2 33
PU ECOLOGICAL SOC AMER
PI WASHINGTON
PA 1990 M STREET NW, STE 700, WASHINGTON, DC 20036 USA
SN 2150-8925
J9 ECOSPHERE
JI Ecosphere
PD FEB
PY 2011
VL 2
IS 2
AR UNSP 19
DI 10.1890/ES10-00190.1
PG 11
WC Ecology
SC Environmental Sciences & Ecology
GA V30IS
UT WOS:000208810300007
ER
PT J
AU Thomas, JM
Ashbolt, NJ
AF Thomas, Jacqueline M.
Ashbolt, Nicholas J.
TI Do Free-Living Amoebae in Treated Drinking Water Systems Present an
Emerging Health Risk?
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Review
ID DOMESTIC TAP-WATER; INTRACELLULAR BACTERIAL PATHOGENS; CONTACT-LENS
WEARERS; LEGIONELLA-PNEUMOPHILA; ACANTHAMOEBA-CASTELLANII;
MYCOBACTERIUM-AVIUM; RESISTING BACTERIA; OPPORTUNISTIC PATHOGENS;
SIMKANIA-NEGEVENSIS; NAEGLERIA-FOWLERI
AB There is an expanding body of evidence that free-living amoebae (FLA) increase both the numbers and virulence of water-based, human-pathogenic, amoeba-resisting microorganisms (ARM). Legionella spp., Mycobacterium spp., and other opportunistic human pathogens are known to be both ARM and also the etiologic agents of potentially fatal human lung infections. However, comparatively little is known about the FLA that may facilitate ARM growth in drinking water. This review examines the available literature on FLA in treated drinking water systems; in total 26 studies from 18 different countries. FLA were reported to breakthrough the water treatment barrier and enter distribution systems, in addition to the expected post-treatment system ingress. Once in the distribution system there is evidence of FLA colonization and regrowth especially in reservoirs and in-premise plumbing storage tanks. At the point of use the average FLA detection rate was 45% but highly variable (n = 16, sigma = 31) due to both differences in both assay methods and the type of water systems examined. This review reveals that FLA are consistently detected in treated drinking water systems around the world and present a yet unquantified emerging health risk. However, more research is urgently required before accurate risks assessments can be undertaken to assess the impacts on human health, in households and institutions, due to exposure to FLA facilitated pathogenic ARM.
C1 [Thomas, Jacqueline M.; Ashbolt, Nicholas J.] Univ New S Wales, Water Res Ctr, Sch Civil & Environm Engn, Sydney, NSW 2052, Australia.
[Ashbolt, Nicholas J.] US EPA, Natl Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA.
RP Thomas, JM (reprint author), Univ New S Wales, Water Res Ctr, Sch Civil & Environm Engn, Sydney, NSW 2052, Australia.
EM j.thomas@student.unsw.edu.au
FU American Australian Association; Sydney Water
FX We acknowledge the American Australian Association for their support,
via a Research Fellowship and Sydney Water for financial support, both
to the primary author. Views expressed are not necessarily those of the
U.S. EPA.
NR 117
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U1 4
U2 52
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD FEB 1
PY 2011
VL 45
IS 3
BP 860
EP 869
DI 10.1021/es102876y
PG 10
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 711HG
UT WOS:000286577100005
PM 21194220
ER
PT J
AU Sanchez, BC
Ralston-Hooper, K
Sepulveda, MS
AF Sanchez, Brian C.
Ralston-Hooper, Kimberly
Sepulveda, Maria S.
TI REVIEW OF RECENT PROTEOMIC APPLICATIONS IN AQUATIC TOXICOLOGY
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article; Proceedings Paper
CT 30th Annual Meeting of SETAC-North -America
CY NOV 19-23, 2009
CL New Orleans, LA
SP SETAC N Amer
DE Proteomics; Aquatic toxicology; Fish; Aquatic invertebrates
ID MUSSEL MYTILUS-EDULIS; PROTEIN EXPRESSION SIGNATURES; OXIDATIVE-STRESS;
MASS-SPECTROMETRY; 2-DIMENSIONAL ELECTROPHORESIS; BIOMARKER DISCOVERY;
MICROCYSTIN-LR; SELDI-TOF; RUDITAPES-DECUSSATUS; CADMIUM TOXICITY
AB Over the last decade, the environmental sciences have witnessed an incredible movement towards the utilization of high-throughput molecular tools that are capable of detecting simultaneous changes of hundreds, and even thousands, of molecules and molecular components after exposure of organisms to different environmental stressors. These techniques have received a great deal of attention because they not only offer the potential to unravel novel mechanisms of physiological and toxic action but are also amenable to the discovery of biomarkers of exposure and effects. In this article, we review the state of knowledge of one of these tools in ecotoxicological research: proteomics. We summarize the state of proteomics research in fish, and follow with studies conducted with aquatic invertebrates. A brief discussion on proteomic methods is also presented. We conclude with some ideas for future proteomic studies with fish and aquatic invertebrates. Environ. Toxicol. Chem. 2011;30:274-282. (C) 2010 SETAC
C1 [Sepulveda, Maria S.] Purdue Univ, W Lafayette, IN 47907 USA.
[Sanchez, Brian C.] US Fish & Wildlife Serv, Lakewood, CO USA.
[Ralston-Hooper, Kimberly] US EPA, Ecosyst Res Div, Athens, GA USA.
RP Sepulveda, MS (reprint author), Purdue Univ, W Lafayette, IN 47907 USA.
EM mssepulv@purdue.edu
RI Sepulveda, Maria/P-3598-2014
NR 79
TC 45
Z9 47
U1 6
U2 46
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0730-7268
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD FEB
PY 2011
VL 30
IS 2
BP 274
EP 282
DI 10.1002/etc.402
PG 9
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 710DB
UT WOS:000286490000003
PM 21072841
ER
PT J
AU Balboni, G
Salvadori, S
Marczak, ED
Knapp, BI
Bidlack, JM
Lazarus, LH
Peng, XM
Si, YG
Neumeyer, JL
AF Balboni, Gianfranco
Salvadori, Severo
Marczak, Ewa D.
Knapp, Brian I.
Bidlack, Jean M.
Lazarus, Lawrence H.
Peng, Xuemei
Si, Yu Gui
Neumeyer, John L.
TI Opioid bifunctional ligands from morphine and the opioid pharmacophore
Dmt-Tic
SO EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
DE Bifunctional ligands; Dmt-Tic pharmacophore; Opioid receptors
ID DESIGNED MULTIPLE LIGAND; BIVALENT LIGANDS; INVERSE AGONISM; RECEPTORS;
ANTAGONIST; ANALOGS; NALTRINDOLE; EVOLUTION; BINDING
AB Bifunctional ligands containing an ester linkage between morphine and the delta-selective pharmacophore Dmt-Tic were synthesized, and their binding affinity and functional bioactivity at the mu, delta and kappa opioid receptors determined. Bifunctional ligands containing or not a spacer of beta-alanine between the two pharmacophores lose the mu agonism deriving from morphine becoming partial p agonists mu or mu antagonists 5. Partial kappa agonism is evidenced only for compound 4. Finally, both compounds showed potent delta antagonism. (C) 2010 Elsevier Masson SAS. All rights reserved.
C1 [Balboni, Gianfranco] Univ Cagliari, Dept Toxicol, I-09124 Cagliari, Italy.
[Salvadori, Severo] Univ Ferrara, Dept Pharmaceut Sci, I-44100 Ferrara, Italy.
[Salvadori, Severo] Univ Ferrara, Ctr Biotechnol, I-44100 Ferrara, Italy.
[Knapp, Brian I.; Bidlack, Jean M.] Univ Rochester, Dept Pharmacol & Physiol, Sch Med & Dent, Rochester, NY 14642 USA.
[Marczak, Ewa D.; Lazarus, Lawrence H.] Natl Inst Environm Hlth Sci, Med Chem Grp, Lab Toxicol & Pharmacol, Res Triangle Pk, NC 27709 USA.
[Peng, Xuemei; Si, Yu Gui; Neumeyer, John L.] Harvard Univ, McLean Hosp, Sch Med, Alcohol & Drug Abuse Res Ctr, Belmont, MA 02478 USA.
RP Balboni, G (reprint author), Univ Cagliari, Dept Toxicol, Via Osped 72, I-09124 Cagliari, Italy.
EM gbalboni@unica.it; jneumeyer@mclean.harvard.edu
OI SALVADORI, Severo/0000-0002-8224-2358
FU NIH [RO1-DA14251, K05-DA 00360]; University of Cagliari; University of
Ferrara; NIEHS
FX This work was supported in part by NIH Grants RO1-DA14251 (to J.L.N.),
K05-DA 00360 (to J.M.B.), University of Cagliari (to G.B.), University
of Ferrara (to S.S.), and the Intramural Research Program of the NIH and
NIEHS (to L.H.L.).
NR 27
TC 9
Z9 10
U1 0
U2 8
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0223-5234
J9 EUR J MED CHEM
JI Eur. J. Med. Chem.
PD FEB
PY 2011
VL 46
IS 2
BP 799
EP 803
DI 10.1016/j.ejmech.2010.12.001
PG 5
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA 725AL
UT WOS:000287617500036
PM 21216504
ER
PT J
AU Deng, YM
Edin, ML
Theken, KN
Schuck, RN
Flake, GP
Kannon, MA
DeGraff, LM
Lih, FB
Foley, J
Bradbury, JA
Graves, JP
Tomer, KB
Falck, JR
Zeldin, DC
Lee, CR
AF Deng, Yangmei
Edin, Matthew L.
Theken, Katherine N.
Schuck, Robert N.
Flake, Gordon P.
Kannon, M. Alison
DeGraff, Laura M.
Lih, Fred B.
Foley, Julie
Bradbury, J. Alyce
Graves, Joan P.
Tomer, Kenneth B.
Falck, John R.
Zeldin, Darryl C.
Lee, Craig R.
TI Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase
disruption attenuate acute vascular inflammatory responses in mice
SO FASEB JOURNAL
LA English
DT Article
DE CYP2J2; CYP2C8; EPHX2; EETs; eicosanoids; inflammation
ID NF-KAPPA-B; ACUTE LUNG INJURY; ACUTE PSEUDOMONAS PNEUMONIA;
BLOOD-PRESSURE REGULATION; ARACHIDONIC-ACID; CYTOCHROME-P450
EPOXYGENASES; CORONARY-ARTERIES; EPOXYEICOSATRIENOIC ACIDS; THERAPEUTIC
TARGET; MOLECULAR-CLONING
AB Cytochrome P-450 (CYP)-derived epoxyeicosatrienoic acids (EETs) possess potent anti-inflammatory effects in vitro. However, the effect of increased CYP-mediated EET biosynthesis and decreased soluble epoxide hydrolase (sEH, Ephx2)-mediated EET hydrolysis on vascular inflammation in vivo has not been rigorously investigated. Consequently, we characterized acute vascular inflammatory responses to endotoxin in transgenic mice with endothelial expression of the human CYP2J2 and CYP2C8 epoxygenases and mice with targeted disruption of Ephx2. Compared to wild-type controls, CYP2J2 transgenic, CYP2C8 transgenic, and Ephx2(-/-) mice each exhibited a significant attenuation of endotoxin-induced activation of nuclear factor (NF)-kappa B signaling, cellular adhesion molecule, chemokine and cytokine expression, and neutrophil infiltration in lung in vivo. Furthermore, attenuation of endotoxin-induced NF-kappa B activation and cellular adhesion molecule and chemokine expression was observed in primary pulmonary endothelial cells isolated from CYP2J2 and CYP2C8 transgenic mice. This attenuation was inhibited by a putative EET receptor antagonist and CYP epoxygenase inhibitor, directly implicating CYP epoxygenase-derived EETs with the observed anti-inflammatory phenotype. Collectively, these data demonstrate that potentiation of the CYP epoxygenase pathway by either increased endothelial EET biosynthesis or globally decreased EET hydrolysis attenuates NF-kappa B-dependent vascular inflammatory responses in vivo and may serve as a viable anti-inflammatory therapeutic strategy.-Deng, Y., Edin, M. L., Theken, K. N., Schuck, R. N., Flake, G. P., Kannon, M. A., DeGraff, L. M., Lih, F. B., Foley, J., Bradbury, J. A., Graves, J. P., Tomer, K. B., Falck, J. R., Zeldin, D. C., Lee, C. R. Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice. FASEB J. 25, 703-713 (2011). www.fasebj.org
C1 [Deng, Yangmei; Theken, Katherine N.; Schuck, Robert N.; Kannon, M. Alison; Lee, Craig R.] UNC, Eshelman Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC 27599 USA.
[Edin, Matthew L.; Flake, Gordon P.; DeGraff, Laura M.; Lih, Fred B.; Foley, Julie; Bradbury, J. Alyce; Graves, Joan P.; Tomer, Kenneth B.; Zeldin, Darryl C.] Natl Inst Environm Hlth Sci, Natl Inst Hlth, Div Intramural Res, Res Triangle Pk, NC USA.
[Falck, John R.] Univ Texas SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA.
RP Lee, CR (reprint author), UNC, Eshelman Sch Pharm, Div Pharmacotherapy & Expt Therapeut, CB 7569,Kerr Hall, Chapel Hill, NC 27599 USA.
EM craig_lee@unc.edu
RI Theken, Katherine/H-1098-2012; Tomer, Kenneth/E-8018-2013;
OI Falck, John/0000-0002-9219-7845; Edin, Matthew/0000-0002-7042-500X; Lee,
Craig/0000-0003-3595-5301
FU American Foundation for Pharmaceutical Education; NIH [GM31278,
GM088199, P30 DK34987]; Robert A. Welch Foundation; NIH, NIEHS [Z01
ES050167, Z01 ES025034]; American Heart Association
FX This publication was made possible by a predoctoral fellowship from the
American Foundation for Pharmaceutical Education to K.N.T., NIH grant
GM31278 and support from the Robert A. Welch Foundation to J.R.F., funds
from the Intramural Research Program of the NIH, NIEHS, to K. B. T. (Z01
ES050167) and D.C.Z. (Z01 ES025034), a Beginning Grant-in-Aid from the
American Heart Association and NIH grant GM088199 to C. R. L., and NIH
grant P30 DK34987. The contents of this article are solely the
responsibility of the authors and do not necessarily represent the
official views of the NIEHS, National Institute of General Medical
Sciences, or NIH. D. C. Z. is a coinventor on U.S. Patent No. 6,531,506
B1 (issued March 11, 2003), Inhibition of Epoxide Hydrolases for the
Treatment of Hypertension, and on U. S. Patent No. 6,916,843 B1 (issued
July 12, 2005), Anti-inflammatory Actions of Cytochrome P450
Epoxygenase-Derived Eicosanoids. No other authors declare conflicts of
interest.
NR 52
TC 67
Z9 68
U1 0
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD FEB
PY 2011
VL 25
IS 2
BP 703
EP 713
DI 10.1096/fj.10-171488
PG 11
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 713GZ
UT WOS:000286724800028
PM 21059750
ER
PT J
AU Nayak, AP
Green, BJ
Janotka, E
Blachere, FM
Vesper, SJ
Beezhold, DH
Schmechel, D
AF Nayak, Ajay P.
Green, Brett J.
Janotka, Erika
Blachere, Francoise M.
Vesper, Stephen J.
Beezhold, Donald H.
Schmechel, Detlef
TI Production and Characterization of IgM Monoclonal Antibodies Against
Hyphal Antigens of Stachybotrys Species
SO HYBRIDOMA
LA English
DT Article
ID MACROCYCLIC TRICHOTHECENE MYCOTOXINS; WATER-DAMAGED BUILDINGS;
ASPERGILLUS-VERSICOLOR; PULMONARY HEMORRHAGE; CHARTARUM STRAINS;
STACHYRASE-A; INDOOR MOLD; STACHYHEMOLYSIN; STACHYLYSIN; HEMOLYSIN
AB Stachybotrys is a hydrophilic fungal genus that is well known for its ability to colonize water-damaged building materials in indoor environments. Personal exposure to Stachybotrys chartarum allergens, mycotoxins, cytolytic peptides, and other immunostimulatory macromolecules has been proposed to exacerbate respiratory morbidity. To date, advances in Stachybotrys detection have focused on the identification of unique biomarkers that can be detected in human serum; however, the availability of immunodiagnostic reagents to Stachybotrys species have been limited. In this study, we report the initial characterization of monoclonal antibodies (MAbs) against a semi-purified cytolytic S. chlorohalonata preparation (cScp) derived from hyphae. BALB/c mice were immunized with cScp and hybridomas were screened against the cScp using an antigen-mediated indirect ELISA. Eight immunoglobulin M MAbs were produced and four were specifically identified in the capture ELISA to react with the cScp. Cross-reactivity of the MAbs was tested against crude hyphal extracts derived from 15 Stachybotrys isolates representing nine Stachybotrys species as well as 39 other environmentally abundant fungi using a capture ELISA. MAb reactivity to spore and hyphal antigens was also tested by a capture ELISA and by fluorescent halogen immunoassay (fHIA). ELISA analysis demonstrated that all MAbs strongly reacted with extracts of S. chartarum but not with extracts of 39 other fungi. However, four MAbs showed cross-reactivity to the phylogenetically related genus Memnoniella. fHIA analysis confirmed that greatest MAb reactivity was ultrastructurally localized in hyphae and phialides. The results of this study further demonstrate the feasibility of specific MAb-based immunoassays for the detection of S. chartarum.
C1 [Nayak, Ajay P.; Green, Brett J.; Janotka, Erika; Blachere, Francoise M.; Beezhold, Donald H.; Schmechel, Detlef] NIOSH, Allergy & Clin Immunol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA.
[Nayak, Ajay P.] W Virginia Univ, Dept Microbiol Immunol & Cell Biol, Sch Med, Morgantown, WV 26506 USA.
[Vesper, Stephen J.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
RP Beezhold, DH (reprint author), NIOSH, Allergy & Clin Immunol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, 1095 Willowdale Rd,M-S L-4020, Morgantown, WV 26505 USA.
EM zec1@cdc.gov
FU InterAgency agreement with the National Institute of Environmental
Health Sciences [Y1-ES0001-06]
FX The findings and conclusions in this report are those of the authors and
do not necessarily represent the views of the National Institute for
Occupational Safety and Health. This work was supported in part by an
InterAgency agreement with the National Institute of Environmental
Health Sciences (Y1-ES0001-06).
NR 34
TC 3
Z9 3
U1 0
U2 3
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1554-0014
J9 HYBRIDOMA
JI Hybridoma
PD FEB
PY 2011
VL 30
IS 1
BP 29
EP 36
DI 10.1089/hyb.2010.0071
PG 8
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Immunology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Immunology
GA 726NF
UT WOS:000287728900004
PM 21466283
ER
PT J
AU Shannahan, J
Schladweiler, M
Padilla-Carlin, D
Nyska, A
Richards, J
Ghio, A
Gavett, S
Kodavanti, U
AF Shannahan, Jonathan
Schladweiler, Mette
Padilla-Carlin, Danielle
Nyska, Abraham
Richards, Judy
Ghio, Andrew
Gavett, Stephen
Kodavanti, Urmila
TI The role of cardiovascular disease-associated iron overload in Libby
amphibole-induced acute pulmonary injury and inflammation
SO INHALATION TOXICOLOGY
LA English
DT Article
DE Libby Amphibole; Iron; Inflammation
ID INDUCED LUNG INJURY; ASBESTOS EXPOSURE; HEME OXYGENASE-1;
GENE-EXPRESSION; INTRATRACHEAL INSTILLATION; FERRUGINOUS BODIES;
MESOTHELIAL CELLS; EPITHELIAL-CELLS; RAT; MONTANA
AB Pulmonary toxicity induced by asbestos is thought to be mediated through redox-cycling of fiber-bound and bioavailable iron (Fe). We hypothesized that Libby amphibole (LA)-induced cute lung injury will be exacerbated in rat models of cardiovascular disease (CVD)-associated Fe-overload and oxidative stress. Healthy male Wistar Kyoto (WKY), spontaneously hypertensive (SH) and SH heart failure (SHHF) rats were intratracheally instilled with 0.0, 0.25 or 1.0 mg/rat LA and examined at 1 day, 1 week or 1 month. Although histologically it was not possible to distinguish severity differences between strains in LA-induced initial inflammation and later fibrosis, quantitative assessment of biomarkers showed strain-related differences. LA-induced neutrophilic inflammation was reversible in WKY but persisted more in SH and SHHF. Lung MIP-2 mRNA increased only in WKY at 1 day in response to LA but not in SH and SHHF. Bronchoalveolar lavage fluid (BALF) protein increased in SH but not WKY at 1 week and 1 month, while.-glutamyltransferase and N-acetyl-beta-D-glucosaminidase activities increased in all strains (WKY > SH=SHHF). BALF ferritin levels were high at baseline and increased following LA exposure only in SH and SHHF. Ferritin heavy chain mRNA increased only in SHHF at 1 day. At 1 month ferritin light chain mRNA declined from already high baseline levels in SHHF but increased in WKY and SH suggesting its differential involvement in LA-induced injury in Fe-overload. Unlike WKY, both SHHF and SH failed to increase the lung lining antioxidant, ascorbate, in response to LA. We conclude that underlying CVD-associated Fe-overload is likely linked to persistent lung injury, inflammation and antioxidant decompensation following LA exposure in rats.
C1 [Schladweiler, Mette; Gavett, Stephen; Kodavanti, Urmila] US EPA, Cardiopulm & Immunotoxicol Branch, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Res Triangle Pk, NC 27711 USA.
[Shannahan, Jonathan; Padilla-Carlin, Danielle] Univ N Carolina, Chapel Hill, NC USA.
[Nyska, Abraham] Tel Aviv Univ, Sackler Sch Med, Timrat, Israel.
[Richards, Judy] US EPA, Analyt Chem Core Unit, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Ghio, Andrew] US EPA, Clin Res Branch, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Res Triangle Pk, NC 27711 USA.
RP Kodavanti, U (reprint author), US EPA, Cardiopulm & Immunotoxicol Branch, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, MD B143-01,CIB EPHD NHEERL, Res Triangle Pk, NC 27711 USA.
FU EPA/UNC [CR833237]; University of North Carolina at Chapel Hill
FX This work was supported by EPA/UNC Toxicology Research Program, Training
Agreement CR833237, with the Curriculum in Toxicology, University of
North Carolina at Chapel Hill.
NR 45
TC 7
Z9 7
U1 0
U2 2
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0895-8378
J9 INHAL TOXICOL
JI Inhal. Toxicol.
PD FEB
PY 2011
VL 23
IS 3
BP 129
EP 141
DI 10.3109/08958378.2011.551850
PG 13
WC Toxicology
SC Toxicology
GA 732VA
UT WOS:000288216600002
PM 21391781
ER
PT J
AU Chen, F
Kusaka, H
Bornstein, R
Ching, J
Grimmond, CSB
Grossman-Clarke, S
Loridan, T
Manning, KW
Martilli, A
Miao, SG
Sailor, D
Salamanca, FP
Taha, H
Tewari, M
Wang, XM
Wyszogrodzki, AA
Zhang, CL
AF Chen, Fei
Kusaka, Hiroyuki
Bornstein, Robert
Ching, Jason
Grimmond, C. S. B.
Grossman-Clarke, Susanne
Loridan, Thomas
Manning, Kevin W.
Martilli, Alberto
Miao, Shiguang
Sailor, David
Salamanca, Francisco P.
Taha, Haider
Tewari, Mukul
Wang, Xuemei
Wyszogrodzki, Andrzej A.
Zhang, Chaolin
TI The integrated WRF/urban modelling system: development, evaluation, and
applications to urban environmental problems
SO INTERNATIONAL JOURNAL OF CLIMATOLOGY
LA English
DT Article; Proceedings Paper
CT 7th International Conference on Urban Climate (ICUC-7)
CY JUN 29-JUL 03, 2009
CL Yokohama, JAPAN
SP Int Assoc Urban Climate (IAUC)
DE urban modelling; mesoscale modelling; urban environmental issues; WRF
urban model
ID PEARL RIVER DELTA; MESOSCALE METEOROLOGICAL MODEL; DATA ASSIMILATION
SYSTEM; SINGLE-LAYER; HEAT-ISLAND; CANOPY MODEL; ETA-MODEL; PART I;
PARAMETERIZATION; SIMULATION
AB To bridge the gaps between traditional mesoscale modelling and microscale modelling, the National Center for Atmospheric Research, in collaboration with other agencies and research groups, has developed an integrated urban modelling system coupled to the weather research and forecasting (WRF) model as a community tool to address urban environmental issues. The core of this WRF/urban modelling system consists of the following: (1) three methods with different degrees of freedom to parameterize urban surface processes, ranging from a simple bulk parameterization to a sophisticated multi-layer urban canopy model with an indoor-outdoor exchange sub-model that directly interacts with the atmospheric boundary layer, (2) coupling to fine-scale computational fluid dynamic Reynolds-averaged Navier-Stokes and Large-Eddy simulation models for transport and dispersion (T&D) applications, (3) procedures to incorporate high-resolution urban land use, building morphology, and anthropogenic heating data using the National Urban Database and Access Portal Tool (NUDAPT), and (4) an urbanized high-resolution land data assimilation system. This paper provides an overview of this modelling system; addresses the daunting challenges of initializing the coupled WRF/urban model and of specifying the potentially vast number of parameters required to execute the WRF/urban model; explores the model sensitivity to these urban parameters; and evaluates the ability of WRF/urban to capture urban heat islands, complex boundary-layer structures aloft, and urban plume T&D for several major metropolitan regions. Recent applications of this modelling system illustrate its promising utility, as a regional climate-modelling tool, to investigate impacts of future urbanization on regional meteorological conditions and on air quality under future climate change scenarios. Copyright. (C) 2010 Royal Meteorological Society
C1 [Chen, Fei; Manning, Kevin W.; Tewari, Mukul; Wyszogrodzki, Andrzej A.] Natl Ctr Atmospher Res, Boulder, CO 80307 USA.
[Kusaka, Hiroyuki] Univ Tsukuba, Ctr Computat Sci, Tsukuba, Ibaraki, Japan.
[Bornstein, Robert] San Jose State Univ, Dept Meteorol, San Jose, CA 95192 USA.
[Ching, Jason] US EPA, ORD, Natl Exposure Res Lab, Res Triangle Pk, NC USA.
[Grimmond, C. S. B.; Loridan, Thomas] Kings Coll London, Dept Geog, London WC2R 2LS, England.
[Grossman-Clarke, Susanne] Arizona State Univ, Global Inst Sustainabil, Tempe, AZ USA.
[Martilli, Alberto; Salamanca, Francisco P.] Ctr Res Energy Environm & Technol, Madrid, Spain.
[Miao, Shiguang; Zhang, Chaolin] China Meteorol Adm, Inst Urban Meteorol, Beijing, Peoples R China.
[Sailor, David] Portland State Univ, Mech & Mat Engn Dept, Portland, OR 97207 USA.
[Taha, Haider] Altostratus Inc, Martinez, CA USA.
[Wang, Xuemei] Sun Yat Sen Univ, Dept Environm Sci, Guangzhou 510275, Guangdong, Peoples R China.
[Zhang, Chaolin] Natl Nat Sci Fdn China, Dept Earth Sci, Beijing, Peoples R China.
RP Chen, F (reprint author), Natl Ctr Atmospher Res RAL, POB 3000, Boulder, CO 80307 USA.
EM feichen@ucar.edu
RI Grimmond, Sue/A-2179-2009; Chen, Fei/B-1747-2009; Wang,
Xuemei/B-4521-2012; Sailor, David/E-6308-2014; Wyszogrodzki,
Andrzej/M-1772-2014; Salamanca Palou, Francisco/M-5406-2014; Martilli,
Alberto/H-5426-2015
OI Grimmond, Sue/0000-0002-3166-9415; Sailor, David/0000-0003-1720-8214;
Salamanca Palou, Francisco/0000-0002-4115-7368; Martilli,
Alberto/0000-0002-7795-5871
NR 66
TC 210
Z9 230
U1 30
U2 161
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0899-8418
J9 INT J CLIMATOL
JI Int. J. Climatol.
PD FEB
PY 2011
VL 31
IS 2
SI SI
BP 273
EP 288
DI 10.1002/joc.2158
PG 16
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 718XV
UT WOS:000287160700009
ER
PT J
AU Basselin, M
Ramadan, E
Igarashi, M
Chang, LS
Chen, M
Kraft, AD
Harry, GJ
Rapoport, SI
AF Basselin, Mireille
Ramadan, Epolia
Igarashi, Miki
Chang, Lisa
Chen, Mei
Kraft, Andrew D.
Harry, G. Jean
Rapoport, Stanley I.
TI Imaging upregulated brain arachidonic acid metabolism in HIV-1
transgenic rats (Retracted article. See vol.35, pg. 1386, 2015)
SO JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
LA English
DT Article; Retracted Publication
DE arachidonic acid; brain imaging; eicosanoids; HIV-1; phospholipase A(2)
ID CENTRAL-NERVOUS-SYSTEM; PHOSPHOLIPASE A(2); ADMINISTRATION INCREASES;
FRONTAL-CORTEX; NEUROINFLAMMATION; DISEASE; CYCLOOXYGENASE-2;
ACTIVATION; EXPRESSION; INHIBITOR
AB Human immunodeficiency virus (HIV)-associated infection involves the entry of virus-bearing monocytes into the brain, followed by microglial activation, neuroinflammation, and upregulated arachidonic acid (AA) metabolism. The HIV-1 transgenic (Tg) rat, a noninfectious HIV-1 model, shows neurologic and behavioral abnormalities after 5 months of age. We hypothesized that brain AA metabolism would be elevated in older HIV-1 Tg rats in vivo. Arachidonic acid incorporation from the plasma into the brain of unanesthetized 7-to-9-month-old rats was imaged using quantitative autoradiography, after [1-C-14] AA infusion. Brain phospholipase (PLA(2)) activities and eicosanoid concentrations were measured, and enzymes were localized by immunostaining. AA incorporation coefficients k* and rates J(in), measures of AA metabolism, were significantly higher in 69 of 81 brain regions in HIV-1 Tg than in control rats, as were activities of cytosolic (c) PLA(2)-IV, secretory (s)PLA(2), and calcium independent (i) PLA(2)-VI, as well as prostaglandin E-2 and leukotriene B-4 concentrations. Immunostaining of somatosensory cortex showed elevated cPLA(2)-IV, sPLA(2)-IIA, and cyclooxygenase-2 in neurons. Brain AA incorporation and other markers of AA metabolism are upregulated in HIV-1 Tg rats, in which neurologic changes and neuroinflammation have been reported. Positron emission tomography with [1-C-11] AA could be used to test whether brain AA metabolism is upregulated in HIV-1-infected patients, in relation to cognitive and behavioral disturbances. Journal of Cerebral Blood Flow & Metabolism (2011) 31, 486-493; doi: 10.1038/jcbfm.2010.111; published online 28 July 2010
C1 [Basselin, Mireille; Ramadan, Epolia; Igarashi, Miki; Chang, Lisa; Chen, Mei; Rapoport, Stanley I.] NIA, Brain Physiol & Metab Sect, NIH, Bethesda, MD 20892 USA.
[Kraft, Andrew D.; Harry, G. Jean] Natl Inst Environm Hlth Sci, Lab Toxicol & Pharmacol, NIH, Res Triangle Pk, NC USA.
RP Ramadan, E (reprint author), NIA, Brain Physiol & Metab Sect, NIH, Bldg 9,Room 1S126, Bethesda, MD 20892 USA.
EM ramadanir@mail.nih.gov
FU National Institute on Aging; National Institute of Environmental Health
Science, NIH
FX The research was supported by the Intramural Research Programs of the
National Institute on Aging and the National Institute of Environmental
Health Science, NIH.
NR 39
TC 26
Z9 27
U1 0
U2 8
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0271-678X
EI 1559-7016
J9 J CEREBR BLOOD F MET
JI J. Cereb. Blood Flow Metab.
PD FEB
PY 2011
VL 31
IS 2
BP 486
EP 493
DI 10.1038/jcbfm.2010.111
PG 8
WC Endocrinology & Metabolism; Hematology; Neurosciences
SC Endocrinology & Metabolism; Hematology; Neurosciences & Neurology
GA 715XY
UT WOS:000286930100011
PM 20664612
ER
PT J
AU Davis, MF
Kamel, F
Hoppin, JA
Alavanja, MCR
Freeman, LB
Gray, GC
Nelson, K
Silbergeld, E
AF Davis, Meghan F.
Kamel, Freya
Hoppin, Jane A.
Alavanja, Michael C. R.
Freeman, Laura Beane
Gray, Gregory C.
Nelson, Kenrad
Silbergeld, Ellen
TI Neurologic Symptoms Associated With Raising Poultry and Swine Among
Participants in the Agricultural Health Study
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID GUILLAIN-BARRE-SYNDROME; CAMPYLOBACTER-JEJUNI; PESTICIDE APPLICATORS;
FEEDING OPERATION; PREVALENCE; INFECTION; ANTIBODIES; SPP.; PIGS;
GASTROENTERITIS
AB Objective: Guillain-Barre Syndrome (GBS) is the leading cause of acute peripheral neuropathy worldwide, often associated with recent foodborne infection with Campylobacter jejuni. In this cross-sectional analysis of data from the Agricultural Health Study, we tested whether swine and poultry exposure were associated with increased prevalence of GBS-like neurologic symptoms. Methods: Using multivariate analysis, we tested the symptoms such as numbness and weakness, relevant to inflammatory peripheral neuropathies, among farmers with self-reported occupational poultry or swine exposure compared with farmers who reported no occupational animal exposure. Results: Among swine farmers/workers, prevalence of weakness and numbness were increased (P < 0.05). Among poultry farmers/workers, prevalence of weakness and numbness were increased, but increased prevalence of weakness was not statistically significant. Conclusions: Occupational contact with live poultry or swine, potentially related to C. jejuni exposure, was associated with increased reporting of GBS-like symptoms.
C1 [Davis, Meghan F.; Silbergeld, Ellen] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD 21205 USA.
[Nelson, Kenrad] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA.
[Kamel, Freya; Hoppin, Jane A.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
[Alavanja, Michael C. R.; Freeman, Laura Beane] NCI, Rockville, MD USA.
[Gray, Gregory C.] Univ Florida, Dept Environm & Global Hlth, Coll Publ Hlth & Hlth Profess, Gainesville, FL USA.
RP Davis, MF (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, 615 N Wolfe St, Baltimore, MD 21205 USA.
EM mdavis@jhsph.edu
RI Davis, Meghan/C-1494-2013; Beane Freeman, Laura/C-4468-2015;
OI Davis, Meghan/0000-0002-3475-4578; Beane Freeman,
Laura/0000-0003-1294-4124; Kamel, Freya/0000-0001-5052-6615
FU National Institutes of Health; National Institute of Environmental
Health Sciences [Z01-ES049030-11]; National Cancer Institute
[Z01-CP010119]; Johns Hopkins Bloomberg School of Public Health
FX The authors thank Dr Guy McKhann for his invaluable assistance. This
work was supported in part by the intramural research program of the
National Institutes of Health, the National Institute of Environmental
Health Sciences (Z01-ES049030-11), and the National Cancer Institute
(Z01-CP010119). Meghan Davis is supported by a Johns Hopkins Bloomberg
School of Public Health Sommer scholarship. Each author declares that he
or she has no actual or potential competing financial interest.
NR 41
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Z9 4
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1076-2752
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD FEB
PY 2011
VL 53
IS 2
BP 190
EP 195
DI 10.1097/JOM.0b013e31820805d5
PG 6
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 718OF
UT WOS:000287133100014
PM 21270654
ER
PT J
AU Garcia, JH
Heberling, MT
Thurston, HW
AF Garcia, Jorge H.
Heberling, Matthew T.
Thurston, Hale W.
TI Optimal Pollution Trading Without Pollution Reductions: A Note
SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION
LA English
DT Article
DE water quality trading; flow pollution; wetlands; trading ratio
ID WATER-QUALITY; WETLANDS; BASIN; HABITAT
AB Various kinds of water pollution occur in pulses (e.g., agricultural and urban runoff). Ecosystems, such as wetlands, can serve to regulate these pulses and smooth pollution distributions over time. This smoothing reduces total environmental damages when "instantaneous" damages are marginally increasing. This paper introduces a water quality trading model between a farm (a pulse-pollution source) and a firm (a more steady pollution source) where the object of exchange is the "temporary" retention of runoff as opposed to total runoff reductions. The optimal trading ratio requires firm emissions to be offset by more than a proportional retention of the initial agricultural runoff pulse. The reason is twofold: (1) emissions are steady or constant over time and, in this sense, have relatively larger environmental impact; and (2) certain kinds of runoff management cause delayed environmental damages.
C1 [Garcia, Jorge H.] Pontificia Univ Javeriana, Dept Econ, Bogota, Colombia.
[Heberling, Matthew T.; Thurston, Hale W.] US EPA, NRMRL, Cincinnati, OH 45268 USA.
RP Garcia, JH (reprint author), Pontificia Univ Javeriana, Dept Econ, Edificio Gabriel Giraldo SJ,Calle 40 6-23 P7, Bogota, Colombia.
EM jgarcia-l@javeriana.edu.co
OI Heberling, Matthew/0000-0003-1120-612X
FU National Academy of Sciences, National Research Council
FX We are grateful to Carlos Chavez for insightful comments on an earlier
version. We would also like to thank Jake Beaulieu and Charles Lane for
useful discussion on wetlands and three anonymous reviewers. Jorge H.
Garcia would like to acknowledge that part of this research was
conducted under a postdoctoral research associateship provided by the
National Academy of Sciences, National Research Council. The views
expressed herein are strictly the opinion of the authors and in no
manner represent current or planned policy by U.S. Environmental
Protection Agency.
NR 29
TC 7
Z9 7
U1 1
U2 10
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1093-474X
J9 J AM WATER RESOUR AS
JI J. Am. Water Resour. Assoc.
PD FEB
PY 2011
VL 47
IS 1
BP 52
EP 58
DI 10.1111/j.1752-1688.2010.00476.x
PG 7
WC Engineering, Environmental; Geosciences, Multidisciplinary; Water
Resources
SC Engineering; Geology; Water Resources
GA 711ZA
UT WOS:000286629700006
ER
PT J
AU Morris, J
Willis, J
De Martinis, D
Hansen, B
Laursen, H
Sintes, JR
Kearns, P
Gonzalez, M
AF Morris, Jeff
Willis, Jim
De Martinis, Domenico
Hansen, Bjorn
Laursen, Henrik
Sintes, Juan Riego
Kearns, Peter
Gonzalez, Mar
TI Science policy considerations for responsible nanotechnology decisions
SO NATURE NANOTECHNOLOGY
LA English
DT Article
AB There is a growing literature on the use of science to inform decisions on the environmental, health and safety implications of nanotechnology, but little has been published by those who make such decisions. Here, as officials of the US Environmental Protection Agency, the European Commission and the Organisation for Economic Co-operation and Development, we discuss the types of decision facing government regulators, the new considerations nanotechnology brings to decision-making, the role of science in informing decisions, how regulators cooperate internationally on policy issues, and the challenges that lie ahead.
C1 [Morris, Jeff] US EPA, Off Res & Dev, Washington, DC 20460 USA.
[Willis, Jim; De Martinis, Domenico; Hansen, Bjorn; Laursen, Henrik] European Commiss, Environm DG, B-1049 Brussels, Belgium.
[Sintes, Juan Riego] European Commiss, Joint Res Ctr, Inst Hlth & Consumer Protect, I-21027 Ispra, Varese, Italy.
[Kearns, Peter; Gonzalez, Mar] Org Econ Cooperat & Dev, Environm Directorate, F-75775 Paris 16, France.
RP Morris, J (reprint author), US EPA, Off Res & Dev, Washington, DC 20460 USA.
EM morris.jeff@epamail.epa.gov
RI DE MARTINIS, DOMENICO/G-2311-2015;
OI DE MARTINIS, DOMENICO/0000-0002-7194-0564; Kearns,
Peter/0000-0001-7967-0274
NR 12
TC 31
Z9 31
U1 1
U2 17
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1748-3387
J9 NAT NANOTECHNOL
JI Nat. Nanotechnol.
PD FEB
PY 2011
VL 6
IS 2
BP 73
EP 77
DI 10.1038/nnano.2010.191
PG 5
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
SC Science & Technology - Other Topics; Materials Science
GA 716KW
UT WOS:000286968500001
PM 21151111
ER
PT J
AU Liu, YX
Lo, YC
Qian, L
Crews, FT
Wilson, B
Chen, HL
Wu, HM
Chen, SH
Wei, K
Lu, RB
Ali, S
Hong, JS
AF Liu, Yuxin
Lo, Yi-Ching
Qian, Li
Crews, Fulton Tim
Wilson, Belinda
Chen, Hui-Ling
Wu, Hung-Ming
Chen, Shih-Heng
Wei, Ke
Lu, Ru-Band
Ali, Syed
Hong, Jau-Shyong
TI Verapamil protects dopaminergic neuron damage through a novel
anti-inflammatory mechanism by inhibition of microglial activation
SO NEUROPHARMACOLOGY
LA English
DT Article
DE Calcium channel blocker; Oxidative stress and neuroinflammation
ID CALCIUM-CHANNEL BLOCKERS; LIPOPOLYSACCHARIDE-INDUCED NEUROTOXICITY;
NITRIC-OXIDE SYNTHASE; SUPEROXIDE GENERATION; RACEMIC VERAPAMIL;
CEREBRAL-ISCHEMIA; HUMAN-NEUTROPHILS; NEUROPROTECTION; EXPRESSION;
ANTAGONISTS
AB Verapamil has been shown to be neuroprotective in several acute neurotoxicity models due to blockade of calcium entry into neurons. However, the potential use of veraparnil to treat chronic neurodegenerative diseases has not been reported. Using rat primary mesencephalic neuron/glia cultures, we report that verapamil significantly inhibited LPS-induced dopaminergic neurotoxicity in both pre- and post-treatment experiments. Reconstituted culture studies revealed that the presence of microglia was essential in verapamil-elicited neuroprotection. Mechanistic studies showed that decreased production of inflammatory mediators from LPS-stimulated microglia underlay neuroprotective property of verapamil. Further studies demonstrated that microglial NADPH oxidase (PHOX), the key superoxide-producing enzyme, but not calcium channel in neurons, is the site of action for the neuroprotective effect of verapamil. This conclusion was supported by the following two observations: 1) Verapamil failed to show protective effect on LPS-induced dopaminergic neurotoxicity in PHOX-deficient (deficient in the catalytic subunit of gp91(phox)) neuron/glia cultures: 2) Ligand binding studies showed that the binding of [H-3]Verapamil onto gp91(phox) transfected COS7 cell membranes was higher than the non-transfected control. The calcium channel-independent neuroprotective property of verapamil was further supported by the finding that R(+)-verapamil, a less active form in blocking calcium channel, showed the same potency in neuroprotection, inhibition of pro-inflammatory factors production and binding capacity to gp91(phox) membranes as R(-)-verapamil, the active isomer of calcium channel blocker. In conclusion, our results demonstrate a new indication of verapamil-mediated neuroprotection through a calcium channel-independent pathway and provide a valuable avenue for the development of therapy for inflammation-related neurodegenerative diseases. Published by Elsevier Ltd.
C1 [Liu, Yuxin; Lo, Yi-Ching; Qian, Li; Wilson, Belinda; Chen, Hui-Ling; Wu, Hung-Ming; Chen, Shih-Heng; Wei, Ke; Hong, Jau-Shyong] Natl Inst Environm Hlth Sci, Neuropharmacol Sect, Res Triangle Pk, NC 27709 USA.
[Lo, Yi-Ching] Kaohsiung Med Univ, Dept Pharmacol, Kaohsiung 807, Taiwan.
[Crews, Fulton Tim] Univ N Carolina, Sch Med, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA.
[Liu, Yuxin] Hebei Univ, Sch Pharmaceut Sci, Lab Cell Pharmacol, Baoding, Peoples R China.
[Chen, Hui-Ling; Wu, Hung-Ming; Chen, Shih-Heng; Lu, Ru-Band] Natl Cheng Kung Univ & Hosp, Dept Psychiat, Tainan, Taiwan.
[Ali, Syed] Neurochem Lab NCTR, Jefferson, AR USA.
RP Hong, JS (reprint author), Natl Inst Environm Hlth Sci, Neuropharmacol Sect, Res Triangle Pk, NC 27709 USA.
EM hong3@niehs.nih.gov
FU National Institutes of Health, National Institute of Environmental
Health Sciences, U.S.A.; NIAAA; UNC Bowles Center for Alcohol Studies,
U.S.A.; National Science Council, Taiwan [NSC-96-2320-B-037-039-MY3]
FX This research was supported by the Intramural Research Program of the
National Institutes of Health, National Institute of Environmental
Health Sciences, U.S.A.; the Extramural grants from NIAAA (FTC) as well
as The UNC Bowles Center for Alcohol Studies (YL and FTC), U.S.A.; and
the National Science Council (grant NSC-96-2320-B-037-039-MY3), Taiwan.
NR 34
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U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0028-3908
J9 NEUROPHARMACOLOGY
JI Neuropharmacology
PD FEB-MAR
PY 2011
VL 60
IS 2-3
BP 373
EP 380
DI 10.1016/j.neuropharm.2010.10.002
PG 8
WC Neurosciences; Pharmacology & Pharmacy
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 717NL
UT WOS:000287054600021
PM 20950631
ER
PT J
AU Haseman, JK
Strickland, J
Allen, D
Salicru, E
Paris, M
Tice, RR
Stokes, WS
AF Haseman, Joseph K.
Strickland, Judy
Allen, David
Salicru, Eleni
Paris, Michael
Tice, Raymond R.
Stokes, William S.
TI Safety assessment of allergic contact dermatitis hazards: An analysis
supporting reduced animal use for the murine local lymph node assay
SO REGULATORY TOXICOLOGY AND PHARMACOLOGY
LA English
DT Article
DE Local lymph node assay; Skin sensitization; Alternative test method;
Animal reduction; Sample size; OECD test guideline 429
ID ICCVAM EVALUATION; CLASSIFICATION
AB The original Organisation for Economic Co-operation and Development Test Guideline 429 (OECD TG 429) for the murine local lymph node assay (LLNA) required five mice/group if mice were processed individually. We used data from 83 LLNA tests (275 treated groups) to determine the impact on the LLNA outcome of reducing the group size from five to four. From DPM measurements, we formed all possible four- and five-mice combinations for the treated and control groups. Stimulation index (SI) values from each four-mice combination were compared with those from five-mice combinations, and agreement (both SI <3 or both SI >= 3) determined. Average agreement between group sizes was 97.5% for the 275 treated groups. Compared test-by-test, 90% (75/83) of the tests had 100% agreement: agreement was 83% for the remaining eight tests. Disagreement was due primarily to variability in animal responses and closeness of the SI to three (positive response threshold) rather than to group size reduction. We conclude that using four rather than five mice per group would reduce animal use by 20% without adversely impacting LLNA performance. This analysis supported the recent update to OECD TG 429 allowing a minimum of four mice/group when each mouse is processed individually. Published by Elsevier Inc.
C1 [Haseman, Joseph K.] JK Haseman Consulting, Raleigh, NC 27614 USA.
[Strickland, Judy; Allen, David; Salicru, Eleni; Paris, Michael] Integrated Lab Syst Inc, Res Triangle Pk, NC 27709 USA.
[Tice, Raymond R.] Natl Inst Environm Hlth Sci, Natl Toxicol Program, Biomol Screening Branch, Res Triangle Pk, NC 27709 USA.
[Stokes, William S.] Natl Inst Environm Hlth Sci, Natl Toxicol Program, Interagcy Ctr Evaluat Alternat Toxicol Methods, Res Triangle Pk, NC 27709 USA.
RP Stokes, WS (reprint author), 530 Davis Dr,POB 12233,K2-16, Res Triangle Pk, NC 27709 USA.
EM stokes@niehs.nih.gov
FU National Institutes of Health, National Institute of Environmental
Health Sciences; NIEHS [N01-ES 35504]
FX This work was supported by the Intramural Research Program of the
National Institutes of Health, National Institute of Environmental
Health Sciences. ILS staff are supported by NIEHS contract N01-ES 35504.
The views expressed in this manuscript do not necessarily represent the
official position of any US Federal agency.
NR 14
TC 2
Z9 3
U1 0
U2 2
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0273-2300
J9 REGUL TOXICOL PHARM
JI Regul. Toxicol. Pharmacol.
PD FEB
PY 2011
VL 59
IS 1
BP 191
EP 196
DI 10.1016/j.yrtph.2010.10.004
PG 6
WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology
SC Legal Medicine; Pharmacology & Pharmacy; Toxicology
GA 727BM
UT WOS:000287772300020
PM 20974208
ER
PT J
AU Tinfo, NS
Hotchkiss, MG
Buckalew, AR
Zorrilla, LM
Cooper, RL
Laws, SC
AF Tinfo, Nicole S.
Hotchkiss, Michelle G.
Buckalew, Angela R.
Zorrilla, Leah M.
Cooper, Ralph L.
Laws, Susan C.
TI Understanding the effects of atrazine on steroidogenesis in rat
granulosa and H295R adrenal cortical carcinoma cells
SO REPRODUCTIVE TOXICOLOGY
LA English
DT Article
DE Atrazine; Chlorotriazine herbicides; Steroidogenesis; Granulosa cells;
Estradiol; Progesterone
ID MALE WISTAR RATS; AROMATASE-ACTIVITY; IN-VITRO; METABOLITES; HERBICIDES;
MECHANISM; ANDROSTENEDIONE; IDENTIFICATION; EXPRESSION; PESTICIDES
AB Atrazine (2-chloro-4-ethylamino-6-isopropylamino-s-triazine) was introduced in the 1950s as a broad spectrum herbicide, and remains one of the most widely used herbicides in the United States. Several studies have suggested that atrazine modifies steroidogenesis and may disrupt reproductive function and development in a variety of species. A primary concern has been whether atrazine increases the synthesis of estrogens, perhaps by enhancing aromatase gene expression and activity. In this study, the effect of atrazine was compared in cultures using primary granulosa cells and H295R adrenal cortical carcinoma cells. Atrazine (10 mu M), but not its metabolite, 2-chloro-4.6-diamino-1,15-triazine (DACT), significantly increased estradiol production and aromatase activity in granulosa cell cultures only when measured for 1-h following 24h of exposure. In H295R cells, atrazine (10 mu M) increased estradiol and estrone production. Importantly, atrazine (10 mu M) increased progesterone production from both cell types suggesting a broader effect of atrazine on steroidogenesis. Published by Elsevier Inc.
C1 [Tinfo, Nicole S.; Hotchkiss, Michelle G.; Buckalew, Angela R.; Zorrilla, Leah M.; Cooper, Ralph L.; Laws, Susan C.] US EPA, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab, Endocrine Toxicol Branch,Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Tinfo, Nicole S.; Zorrilla, Leah M.] N Carolina State Univ, Dept Mol Biomed Sci, Coll Vet Med, Raleigh, NC 27606 USA.
RP Laws, SC (reprint author), US EPA, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab, Endocrine Toxicol Branch,Off Res & Dev, MD 72,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM laws.susan@epa.gov
FU United States Environmental Protection Agency/North Carolina State
University [CR83323501]
FX This work was supported by the United States Environmental Protection
Agency/North Carolina State University Cooperative Training agreement
(CR83323501) to NCSU. We gratefully acknowledge the contributions of;
Guillermo Orozco, Patty Dillard, Alvin Moore, and Faye Pothress of New
Year Tech, Raleigh, NC, for their technical support and assistance with
animal care; Saro Jayaraman, Atlantic Ecology Division, NHEERL, U.S.
EPA, for conducting the analytical chemistry analysis; Carmen Wood,
Toxicology Assessment Division, NHEERL, U.S. EPA, for performing the
real-time PCR; and Drs. Sally Darney, Tammy Stoker, Mike Narotsky
(NHEERL, U.S. EPA), and Dr. lane Christenson, University of Kansas
Medical Center. for their reviews and helpful comments on earlier drafts
of the manuscript.
NR 29
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U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0890-6238
J9 REPROD TOXICOL
JI Reprod. Toxicol.
PD FEB
PY 2011
VL 31
IS 2
BP 184
EP 193
DI 10.1016/j.reprotox.2010.11.005
PG 10
WC Reproductive Biology; Toxicology
SC Reproductive Biology; Toxicology
GA 735LX
UT WOS:000288417200010
PM 21126571
ER
PT J
AU Romeis, J
Hellmich, RL
Candolfi, MP
Carstens, K
De Schrijver, A
Gatehouse, AMR
Herman, RA
Huesing, JE
McLean, MA
Raybould, A
Shelton, AM
Waggoner, A
AF Romeis, Joerg
Hellmich, Richard L.
Candolfi, Marco P.
Carstens, Keri
De Schrijver, Adinda
Gatehouse, Angharad M. R.
Herman, Rod A.
Huesing, Joseph E.
McLean, Morven A.
Raybould, Alan
Shelton, Anthony M.
Waggoner, Annabel
TI Recommendations for the design of laboratory studies on non-target
arthropods for risk assessment of genetically engineered plants
SO TRANSGENIC RESEARCH
LA English
DT Article
DE Environmental risk assessment; Non-target effects; Study design; Tiered
risk assessment; Transgenic crops
ID PREDATOR CHRYSOPERLA-CARNEA; BT CORN POLLEN; BACILLUS-THURINGIENSIS
TOXINS; PARASITOID COTESIA-PLUTELLAE; GALANTHUS-NIVALIS AGGLUTININ;
ORIUS-INSIDIOSUS HETEROPTERA; TRANSGENIC CORN; COLEOMEGILLA-MACULATA;
INSECTICIDAL PROTEINS; APIS-MELLIFERA
AB This paper provides recommendations on experimental design for early-tier laboratory studies used in risk assessments to evaluate potential adverse impacts of arthropod-resistant genetically engineered (GE) plants on non-target arthropods (NTAs). While we rely heavily on the currently used proteins from Bacillus thuringiensis (Bt) in this discussion, the concepts apply to other arthropod-active proteins. A risk may exist if the newly acquired trait of the GE plant has adverse effects on NTAs when they are exposed to the arthropod-active protein. Typically, the risk assessment follows a tiered approach that starts with laboratory studies under worst-case exposure conditions; such studies have a high ability to detect adverse effects on non-target species. Clear guidance on how such data are produced in laboratory studies assists the product developers and risk assessors. The studies should be reproducible and test clearly defined risk hypotheses. These properties contribute to the robustness of, and confidence in, environmental risk assessments for GE plants. Data from NTA studies, collected during the analysis phase of an environmental risk assessment, are critical to the outcome of the assessment and ultimately the decision taken by regulatory authorities on the release of a GE plant. Confidence in the results of early-tier laboratory studies is a precondition for the acceptance of data across regulatory jurisdictions and should encourage agencies to share useful information and thus avoid redundant testing.
C1 [Romeis, Joerg] Agroscope Reckenholz Tanikon Res Stn ART, CH-8046 Zurich, Switzerland.
[Hellmich, Richard L.] Iowa State Univ, USDA ARS, Corn Insects & Crop Genet Res Unit, Genet Lab Insectary,Dept Entomol, Ames, IA 50011 USA.
[Candolfi, Marco P.] Innovat Environm Serv IES Ltd, CH-4108 Witterswil, Switzerland.
[Carstens, Keri] Pioneer Hi Bred, Regulatory Sci, Ankeny, IA 50021 USA.
[De Schrijver, Adinda] Sci Inst Publ Hlth, Div Biosafety & Biotechnol, B-1050 Brussels, Belgium.
[Gatehouse, Angharad M. R.] Newcastle Univ, Sch Biol, Inst Res & Sustainabil, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
[Herman, Rod A.] Dow AgroSci LLC, Indianapolis, IN 46268 USA.
[Huesing, Joseph E.] Monsanto Co, St Louis, MO 63167 USA.
[McLean, Morven A.] ILSI Res Fdn, Ctr Environm Risk Assessment, Washington, DC 20005 USA.
[Raybould, Alan] Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England.
[Shelton, Anthony M.] Cornell Univ NYSAES, Geneva, NY 14456 USA.
[Waggoner, Annabel] US EPA, Off Pesticide Programs, Biopesticides & Pollut Prevent Div, Washington, DC 20460 USA.
RP Romeis, J (reprint author), Agroscope Reckenholz Tanikon Res Stn ART, Reckenholzstr 191, CH-8046 Zurich, Switzerland.
EM joerg.romeis@art.admin.ch
RI Romeis, Joerg/J-5360-2013
NR 121
TC 93
Z9 101
U1 3
U2 31
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-8819
J9 TRANSGENIC RES
JI Transgenic Res.
PD FEB
PY 2011
VL 20
IS 1
BP 1
EP 22
DI 10.1007/s11248-010-9446-x
PG 22
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
Biotechnology & Applied Microbiology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA 705AQ
UT WOS:000286100500001
PM 20938806
ER
PT J
AU Martinovic-Weigelt, D
Wang, RL
Villeneuve, DL
Bencic, DC
Lazorchak, J
Ankley, GT
AF Martinovic-Weigelt, Dalma
Wang, Rong-Lin
Villeneuve, Daniel L.
Bencic, David C.
Lazorchak, Jim
Ankley, Gerald T.
TI Gene expression profiling of the androgen receptor antagonists flutamide
and vinclozolin in zebrafish (Danio rerio) gonads
SO AQUATIC TOXICOLOGY
LA English
DT Article
DE Transcriptomics; Endocrine disruption; Anti-androgens; Fish; Flutamide;
Vinclozolin
ID ENDOCRINE-DISRUPTING COMPOUNDS; ADULT MALE-RAT; FATHEAD MINNOW;
ANTIANDROGEN FLUTAMIDE; PIMEPHALES-PROMELAS; BOVINE SPERMATOZOA; SEX
DETERMINATION; END-POINTS; MICROARRAY; FISH
AB The studies presented in this manuscript focus on characterization of transcriptomic responses to anti-androgens in zebrafish (Danio rerio). Research on the effects of anti-androgens in fish has been characterized by a heavy reliance on apical endpoints, and molecular mechanisms of action (MOA) of anti-androgens remain poorly elucidated. In the present study, we examined effects of a short term exposure (24-96 h) to the androgen receptor antagonists flutamide (FLU) and vinclozolin (VZ) on gene expression in gonads of sexually mature zebrafish, using commercially available zebrafish oligonucleotide microarrays (4 x 44K platform). We found that VZ and FLU potentially impact reproductive processes via multiple pathways related to steroidogenesis, spermatogenesis, and fertilization. Observed changes in gene expression often were shared by VZ and FLU, as demonstrated by overlap in differentially-expressed genes and enrichment of several common key pathways including: (1) integrin and actin signaling, (2) nuclear receptor 5A1 signaling, (3) fibroblast growth factor receptor signaling, (4) polyamine synthesis, and (5) androgen synthesis. This information should prove useful to elucidating specific mechanisms of reproductive effects of anti-androgens in fish, as well as developing biomarkers for this important class of endocrine-active chemicals. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Martinovic-Weigelt, Dalma] Univ St Thomas, St Paul, MN 55105 USA.
[Martinovic-Weigelt, Dalma; Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA.
[Wang, Rong-Lin; Bencic, David C.; Lazorchak, Jim] US EPA, Off Res & Dev, Natl Exposure Res Lab, Ecol Exposure Res Div, Cincinnati, OH 45268 USA.
RP Martinovic-Weigelt, D (reprint author), Univ St Thomas, Mail OWS 390,2115 Summit Ave, St Paul, MN 55105 USA.
EM dalma@stthomas.edu
OI Martinovic-Weigelt, Dalma/0000-0002-9973-4965; Lazorchak,
James/0000-0002-7354-7571
FU USEPA National Center for Computational Toxicology
FX This work was supported by the USEPA National Center for Computational
Toxicology. The manuscript has been reviewed in accordance with USEPA
guidelines and approved for publication. Approval does not indicate that
the contents reflect the views of either Agency, nor does mention of
trade names or commercial products constitute endorsement or
recommendation for use. The views expressed are those of the authors and
do not necessarily reflect USEPA policy.
NR 67
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U1 4
U2 46
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-445X
J9 AQUAT TOXICOL
JI Aquat. Toxicol.
PD JAN 25
PY 2011
VL 101
IS 2
BP 447
EP 458
DI 10.1016/j.aquatox.2010.10.003
PG 12
WC Marine & Freshwater Biology; Toxicology
SC Marine & Freshwater Biology; Toxicology
GA 722HS
UT WOS:000287423900018
PM 21126777
ER
PT J
AU Hiatt, MH
AF Hiatt, Michael H.
TI Internal standards: A source of analytical bias for volatile organic
analyte determinations
SO JOURNAL OF CHROMATOGRAPHY A
LA English
DT Article
DE Volatile organic compounds; Internal standards; Bias; Biota; Soil;
Water; Analyses
ID SAMPLES; ERROR
AB The use of internal standards in the determination of volatile organic compounds as described in SW-846 Method 8260C introduces a potential for bias in results once the internal standards (ISTDs) are added to a sample for analysis. The bias is relative to the dissimilarity between the analyte and internal standard physical properties that influence how easily analytes are separated from a matrix and concentrated during analysis.
Method 5032 is a vacuum distillation procedure for extracting analytes from a sample for use with Method 8260C. Vacuum distillation is also incorporated within another GC/MS analytical procedure, Method 8261A. Method 8260C/5032 and Method 8261A are experimentally identical, however, Method 8261A uses internal standards differently by relating the recovery of each compound to its boiling point and relative volatility. By processing each analysis (water, soil, and biota) using both Method 8260C and Method 8261A, the two approaches are compared on the basis of analyte bias and the failure rate of the quality controls.
Analytes were grouped by how similar their boiling points and natural log of their relative volatilities (In RVs) were to their Method 8260C recommended ISTDs. For the most similar analytes, the Method 8260C determinations yielded an average bias less than 10% and a failure to meet calibration criteria less than 7%. However, as the difference between analyte and ISTD became greater the bias increased to over 40% (matrix dependent) and its calibration failure rate approached 70%. In comparison, when the Method 8260C data were reprocessed as Method 8261A determinations, this trend for groupings was minimized with biases increasing from 6% to only 20% and the calibration failure rate went from 0% to 15%. Published by Elsevier B.V.
C1 US EPA, Natl Exposure Res Lab, Div Environm Sci, Las Vegas, NV 89193 USA.
RP Hiatt, MH (reprint author), US EPA, Natl Exposure Res Lab, Div Environm Sci, POB 93478, Las Vegas, NV 89193 USA.
EM hiatt.mike@epa.gov
NR 11
TC 2
Z9 2
U1 1
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0021-9673
J9 J CHROMATOGR A
JI J. Chromatogr. A
PD JAN 21
PY 2011
VL 1218
IS 3
BP 498
EP 503
DI 10.1016/j.chroma.2010.11.078
PG 6
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA 712QI
UT WOS:000286680900017
PM 21176843
ER
PT J
AU Gibbs-Flournoy, EA
Bromberg, PA
Hofer, TPJ
Samet, JM
Zucker, RM
AF Gibbs-Flournoy, Eugene A.
Bromberg, Philip A.
Hofer, Thomas P. J.
Samet, James M.
Zucker, Robert M.
TI Darkfield-Confocal Microscopy detection of nanoscale particle
internalization by human lung cells
SO PARTICLE AND FIBRE TOXICOLOGY
LA English
DT Article
ID SLIDE-BASED SYSTEMS; ULTRAFINE PARTICLES; QUALITY ASSESSMENT;
NANOPARTICLES; NANOMATERIALS; PERFORMANCE; EXPOSURE; HEALTH
AB Background: Concerns over the health effects of nanomaterials in the environment have created a need for microscopy methods capable of examining the biological interactions of nanoparticles (NP). Unfortunately, NP are beyond the diffraction limit of resolution for conventional light microscopy (similar to 200 nm). Fluorescence and electron microscopy techniques commonly used to examine NP interactions with biological substrates have drawbacks that limit their usefulness in toxicological investigation of NP. EM is labor intensive and slow, while fluorescence carries the risk of photobleaching the sample and has size resolution limits. In addition, many relevant particles lack intrinsic fluorescence and therefore can not be detected in this manner. To surmount these limitations, we evaluated the potential of a novel combination of darkfield and confocal laser scanning microscopy (DF-CLSM) for the efficient 3D detection of NP in human lung cells. The DF-CLSM approach utilizes the contrast enhancements of darkfield microscopy to detect objects below the diffraction limit of 200 nm based on their light scattering properties and interfaces it with the power of confocal microscopy to resolve objects in the z-plane.
Results: Validation of the DF-CLSM method using fluorescent polystyrene beads demonstrated spatial colocalization of particle fluorescence (Confocal) and scattered transmitted light (Darkfield) along the X, Y, and Z axes. DF-CLSM imaging was able to detect and provide reasonable spatial locations of 27 nm TiO2 particles in relation to the stained nuclei of exposed BEAS 2B cells. Statistical analysis of particle proximity to cellular nuclei determined a significant difference between 5 min and 2 hr particle exposures suggesting a time-dependant internalization process.
Conclusions: DF-CLSM microscopy is an alternative to current conventional light and electron microscopy methods that does not rely on particle fluorescence or contrast in electron density. DF-CLSM is especially well suited to the task of establishing the spatial localization of nanoparticles within cells, a critical topic in nanotoxicology. This technique has advantages to 2D darkfield microscopy as it visualizes nanoparticles in 3D using confocal microscopy. Use of this technique should aid toxicological studies related to observation of NP interactions with biological endpoints at cellular and subcellular levels.
C1 [Samet, James M.] US EPA, Environmental Publ Hlth Div, NHEERL, Chapel Hill, NC 27599 USA.
[Gibbs-Flournoy, Eugene A.] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC USA.
[Bromberg, Philip A.] Univ N Carolina, Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC USA.
[Hofer, Thomas P. J.] Clin Cooperat Grp Inflammatory Lung Dis, Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Gauting, Germany.
[Zucker, Robert M.] US EPA, Toxicol Assessment Div, NHEERL, Res Triangle Pk, NC 27711 USA.
RP Samet, JM (reprint author), US EPA, Environmental Publ Hlth Div, NHEERL, Chapel Hill, NC 27599 USA.
EM samet.james@epa.gov
FU NIEHS NIH HHS [T32 ES007126]
NR 39
TC 18
Z9 18
U1 0
U2 21
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-8977
J9 PART FIBRE TOXICOL
JI Part. Fibre Toxicol.
PD JAN 19
PY 2011
VL 8
AR 2
DI 10.1186/1743-8977-8-2
PG 11
WC Toxicology
SC Toxicology
GA 715ZL
UT WOS:000286934400001
PM 21247485
ER
PT J
AU Biales, AD
Bencic, DC
Flick, RL
Blocksom, KA
Lazorchak, JM
Lattier, DL
AF Biales, Adam D.
Bencic, David C.
Flick, Robert L.
Blocksom, Karen A.
Lazorchak, James M.
Lattier, David L.
TI Proteomic analysis of a model fish species exposed to individual
pesticides and a binary mixture
SO AQUATIC TOXICOLOGY
LA English
DT Article
DE DIGE; Mixtures; Biomarkers; Pimephales promelas; Pyrethroid;
Organophosphate; Proteomics
ID RESPONSE MEDIATOR PROTEIN-1; GENE-EXPRESSION; ACUTE TOXICITY;
RAINBOW-TROUT; PYRETHROID INSECTICIDE; ONCORHYNCHUS-MYKISS;
PARKINSONS-DISEASE; STATISTICAL-MODEL; NERVOUS-SYSTEM; CHLORPYRIFOS
AB Pesticides are nearly ubiquitous in surface waters of the United States, where they often are found as mixtures. The molecular mechanisms underlying the toxic effects of sub-lethal exposure to pesticides as both individual and mixtures are unclear. The current work aims to identify and compare differentially expressed proteins in brains of male fathead minnows (Pimephales promelas) exposed for 72 h to permethrin (7.5 mu g/L), terbufos (57.5 mu g/L) and a binary mixture of both. Twenty-four proteins were found to be differentially expressed among all three treatments relative to the control using an ANOVA followed by a Dunnett's post hoc test (p <= 0.05). One protein was found to be differentially expressed among all treatment groups and one protein was in common between the terbufos and the mixture group. Fifteen spots were successfully sequenced using LC-MS/MS sequencing. Proteins associated with the ubiquitin-proteasome system, glycolysis, the cytoskeleton and hypoxia were enriched. As a second objective, we attempted to establish protein expression signatures (PES) for individual permethrin and terbufos exposures. We were unable to generate a useable PES for terbufos; however, the permethrin PES was able to distinguish between control and permethrin-exposed individuals in an independent experiment with an accuracy of 87.5%. This PES also accurately classified permethrin exposed individuals when the exposure occurred as part of a mixture. The identification of proteins differentially expressed as a result of pesticide exposure represent a step forward in the understanding of mechanisms of toxicity of permethrin and terbufos. They also allow a comparison of molecular responses of the binary mixture to single exposures. The permethrin PES is the first step in establishing a method to determine exposures in real-world scenarios. Published by Elsevier B.V.
C1 [Biales, Adam D.; Bencic, David C.; Flick, Robert L.; Blocksom, Karen A.; Lazorchak, James M.; Lattier, David L.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Washington, DC USA.
RP Biales, AD (reprint author), AWBERC, 26 W MLK,MS 592, Cincinnati, OH 45268 USA.
EM biales.adam@epa.gov
OI Lazorchak, James/0000-0002-7354-7571
FU United States Environmental Protection Agency through its Office of
Research and Development
FX The United States Environmental Protection Agency through its Office of
Research and Development partially funded and collaborated on the
research described here. It has been subjected to Agency review and
approved for publication. The authors would like to acknowledge CB, FM
and ZD for their dedicated work on this project as well as their
encouragement.
NR 67
TC 17
Z9 17
U1 1
U2 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-445X
J9 AQUAT TOXICOL
JI Aquat. Toxicol.
PD JAN 17
PY 2011
VL 101
IS 1
BP 196
EP 206
DI 10.1016/j.aquatox.2010.09.019
PG 11
WC Marine & Freshwater Biology; Toxicology
SC Marine & Freshwater Biology; Toxicology
GA 715BR
UT WOS:000286855900021
PM 20974496
ER
PT J
AU Liu, GL
Naja, GM
Kalla, P
Scheidt, D
Gaiser, E
Cai, Y
AF Liu, Guangliang
Naja, G. Melodie
Kalla, Peter
Scheidt, Dan
Gaiser, Evelyn
Cai, Yong
TI Legacy and Fate of Mercury and Methylmercury in the Florida Everglades
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID PERIPHYTON; PEAT
AB Mass inventories of total Hg (THg) and methylmercury (MeHg) and mass budgets of Hg newly deposited during the 2005 dry and wet seasons were constructed for the Everglades. As a sink for Hg, the Everglades has accumulated 914, 1138, 4931, and 7602 kg of legacy THg in its 4 management units, namely Water Conservation Area (WCA) 1, 2, 3, and the Everglades National Park (ENP), respectively, with most Hg being stored in soil. The current annual Hg inputs account only for 1-2% of the legacy Hg. Mercury transport across management units during a season amounts to 1% or less of Hg storage, except for WCA 2 where inflow inputs can contribute 4% of total MeHg storage. Mass budget suggests distinct spatiality for cycling of seasonally deposited Hg, with significantly lower THg fluxes entering water and floc in ENP than in the WCAs. Floc in WCAs can retain a considerable fraction (around 16%) of MeHg produced from the newly deposited Hg during the wet season. This work is important for evaluating the magnitude of legacy Hg contamination and for predicting the fate of new Hg in the Everglades, and provides a methodological example for large-scale studies on Hg cycling in wetlands.
C1 [Liu, Guangliang; Cai, Yong] Florida Int Univ, Dept Chem & Biochem, Miami, FL 33199 USA.
[Liu, Guangliang; Gaiser, Evelyn; Cai, Yong] Florida Int Univ, SE Environm Res Ctr, Miami, FL 33199 USA.
[Naja, G. Melodie] Everglades Fdn, Dept Sci, Palmetto Bay, FL 33157 USA.
[Kalla, Peter] US EPA, Sci & Ecosyst Support Div, Athens, GA 30605 USA.
[Scheidt, Dan] US EPA, Water Protect Div, Athens, GA 30605 USA.
[Gaiser, Evelyn] Florida Int Univ, Dept Biol Sci, Miami, FL 33199 USA.
RP Cai, Y (reprint author), Florida Int Univ, Dept Chem & Biochem, Miami, FL 33199 USA.
EM cai@fiu.edu
RI Cai, Yong/K-9868-2015
OI Cai, Yong/0000-0002-2811-4638
FU R-EMAP; EPA's South Florida Geographic Initiative; Army Corps of
Engineers; Critical Ecosystem Studies Initiative of Everglades National
Park; U.S. Department of the Interior; Florida Department of
Environmental Protection; Everglades Foundation; Bailey Wildlife
Foundation; Darden Foundation; Natural Science Foundation of China
FX This work was sponsored by R-EMAP, EPA's South Florida Geographic
Initiative, the Monitoring and Assessment Plan of the Army Corps of
Engineers Comprehensive Everglades Restoration Plan, the Critical
Ecosystem Studies Initiative of Everglades National Park, U.S.
Department of the Interior, the Mercury Science Program of the Florida
Department of Environmental Protection, the Everglades Foundation, the
Bailey Wildlife Foundation, the Darden Foundation, and the Natural
Science Foundation of China. This is contribution No. 502 of the
Southeast Environmental Research Center at FIU.
NR 25
TC 6
Z9 6
U1 1
U2 31
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD JAN 15
PY 2011
VL 45
IS 2
BP 496
EP 501
DI 10.1021/es101207f
PG 6
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 704YB
UT WOS:000286090500026
PM 21158447
ER
PT J
AU Poynton, HC
Lazorchak, JM
Impellitteri, CA
Smith, ME
Rogers, K
Patra, M
Hammer, KA
Allen, HJ
Vulpe, CD
AF Poynton, Helen C.
Lazorchak, James M.
Impellitteri, Christopher A.
Smith, Mark E.
Rogers, Kim
Patra, Manomita
Hammer, Katherine A.
Allen, H. Joel
Vulpe, Chris D.
TI Differential Gene Expression in Daphnia magna Suggests Distinct Modes of
Action and Bioavailability for ZnO Nanoparticles and Zn Ions
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID NANO-SCALE TIO2; OXIDE NANOPARTICLES; COMPARATIVE TOXICITY; OXIDATIVE
STRESS; ZINC-OXIDE; BULK ZNO; NANOMATERIALS; ENVIRONMENT
AB Zinc oxide nanoparticles (ZnO NPs) are being rapidly developed for use in consumer products, wastewater treatment, and chemotherapy providing several possible routes for ZnO NP exposure to humans and aquatic organisms. Recent studies have shown that ZnO NPs undergo rapid dissolution to Zn(2+), but the relative contribution of Zn(2+) to ZnO NP bioavailability and toxicity is not clear. We show that a fraction of the ZnO NPs in suspension dissolves, and this fraction cannot account for the toxicity of the ZnO NP suspensions to Daphnia magna. Gene expression profiling of D. magna exposed to ZnO NPs or ZnSO(4) at sublethal concentrations revealed distinct modes of toxicity. There was also little overlap in gene expression between ZnO NPs and SiO(x) NPs, suggesting specificity for the ZnO NP expression profile. ZnO NPs effected expression of genes involved in cytoskeletal transport, cellular respiration, and reproduction. A specific pattern of differential expression of three biomarker genes including a multicystatin, ferritin, and C1q containing gene were confirmed for ZnO NP exposure and provide a suite of biomarkers for identifying environmental exposure to ZnO NPs and differentiating between NP and ionic exposure.
C1 [Poynton, Helen C.; Lazorchak, James M.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
[Impellitteri, Christopher A.; Allen, H. Joel] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
[Smith, Mark E.; Hammer, Katherine A.] McConnell Grp Inc, Cincinnati, OH USA.
[Rogers, Kim; Patra, Manomita] US EPA, Natl Exposure Res Lab, Las Vegas, NV 89193 USA.
[Vulpe, Chris D.] Univ Calif Berkeley, Dept Nutrit Sci & Toxicol, Berkeley, CA 94720 USA.
RP Poynton, HC (reprint author), Univ Massachusetts, 100 Morrissey Blvd, Boston, MA 02125 USA.
EM helen.poynton@umb.edu
OI Lazorchak, James/0000-0002-7354-7571
FU U.S. EPA through its Office of Research and Development; Oak Ridge
Institute for Science Education
FX The U.S. EPA through its Office of Research and Development funded and
managed the research described here. It has been subjected to the
Agency's administrative review and approved for publication. We
acknowledge the Oak Ridge Institute for Science Education for support.
We thank Dr. Jason Unrine of University of Kentucky for his helpful
review of this manuscript.
NR 38
TC 75
Z9 77
U1 2
U2 73
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD JAN 15
PY 2011
VL 45
IS 2
BP 762
EP 768
DI 10.1021/es102501z
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 704YB
UT WOS:000286090500065
PM 21142172
ER
PT J
AU Corsini, E
Avogadro, A
Galbiati, V
dell'Agli, M
Marinovich, M
Galli, CL
Germolec, DR
AF Corsini, Emanuela
Avogadro, Anna
Galbiati, Valentina
dell'Agli, Mario
Marinovich, Marina
Galli, Corrado L.
Germolec, Dori R.
TI In vitro evaluation of the immunotoxic potential of perfluorinated
compounds (PFCs)
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Perfluorinated compounds; Immunosuppression; PPAR-alpha receptor;
Cytokine; MMP-9; Whole blood assay
ID NF-KAPPA-B; PROLIFERATOR-ACTIVATED RECEPTORS; PEROXISOME PROLIFERATOR;
PERFLUOROOCTANOIC ACID; PPAR-ALPHA; HUMORAL IMMUNITY; P65 SUBUNIT; CD
RATS; MICE; EXPOSURE
AB There is evidence from both epidemiology and laboratory studies that perfluorinated compounds may be immunotoxic, affecting both cell-mediated and humoral immunity. The overall goal of this study was to investigate the mechanisms underlying the immunotoxic effects of perfluorooctane sulfonate (PFOS) and perfluorooctane acid (PFOA), using in vitro assays. The release of the pro-inflammatory cytokines IL-6, IL-8, and TNF-alpha was evaluated in lipolysaccharide (LPS)-stimulated human peripheral blood leukocytes and in the human promyelocytic cell line THP-1, while the release of IL-4, IL-10 and IFN-gamma was evaluated in phytohaemagglutinin (PHA)-stimulated peripheral blood leukocytes. PFOA and PFOS suppressed LPS-induced TNF-a production in primary human cultures and THP-1 cells, while IL-8 was suppressed only in THP-1 cells. IL-6 release was decreased only by PFOS. Both PFOA and PFOS decreased T-cell derived, PHA-induced IL-4 and IL-10 release, while IFN-gamma release was affected only by PFOS. In all instances. PFOS was more potent than PFOA. Mechanistic investigations carried out in THP-1 cells demonstrated that the effect on cytokine release was pre-transcriptional, as assessed by a reduction in LPS-induced TNF-a mRNA expression. Using siRNA, a role for PPAR-a could be demonstrated for PFOA-induced immunotoxicity, while an inhibitory effect on LPS-induced I-NB degradation could explain the immunomodulatory effect of PFOS. The dissimilar role of PPAR-a in PFOA and PFOS-induced immunotoxicity was consistent with the differing effects observed on LPS-induced MMP-9 release: PFOA, as the PPAR-a agonist fenofibrate, modulated the release, while PFOS had no effect. Overall, these studies suggest that PFCs directly suppress cytokine secretion by immune cells, and that PFOA and PFOS have different mechanisms of action. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Corsini, Emanuela; Avogadro, Anna; Galbiati, Valentina; Marinovich, Marina; Galli, Corrado L.] Univ Milan, Toxicol Lab, Dept Pharmacol Sci, I-20133 Milan, Italy.
[dell'Agli, Mario] Univ Milan, Lab Pharmacognosy, Dept Pharmacol Sci, I-20133 Milan, Italy.
[Germolec, Dori R.] Natl Inst Environm Hlth Sci, Natl Toxicol Program, NIH, Res Triangle Pk, NC USA.
RP Corsini, E (reprint author), Univ Milan, Toxicol Lab, Dept Pharmacol Sci, Via Balzaretti 9, I-20133 Milan, Italy.
EM emanuela.corsini@unimi.it
RI Corsini, Emanuela/B-5602-2011; Dell'Agli, Mario/E-5253-2011;
OI Dell'Agli, Mario/0000-0001-5378-402X; Galli, Corrado
Lodovico/0000-0003-0078-5488; Marinovich, Marina/0000-0003-0625-8101
FU National Institute of Environmental Health Sciences; National Institutes
of Health
FX We would like to thank Dr. Chad Blystone and Dr. Andrew Rooney for their
review and helpful suggestions. This research was supported in part by
the Intramural Research Program of the National Institute of
Environmental Health Sciences, and the National Institutes of Health.
This article may be the work product of an employee or group of
employees of the National Institute of Environmental Health Sciences
(NIEHS), and the National Institutes of Health (NIH), however, the
statements, opinions or conclusions contained therein do not necessarily
represent the statements, opinions or conclusions of NIEHS, NIH or the
United States government.
NR 42
TC 41
Z9 44
U1 4
U2 19
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD JAN 15
PY 2011
VL 250
IS 2
BP 108
EP 116
DI 10.1016/j.taap.2010.11.004
PG 9
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 705KZ
UT WOS:000286128600003
PM 21075133
ER
PT J
AU Beaulieu, JJ
Tank, JL
Hamilton, SK
Wollheim, WM
Hall, RO
Mulholland, PJ
Peterson, BJ
Ashkenas, LR
Cooper, LW
Dahm, CN
Dodds, WK
Grimm, NB
Johnson, SL
McDowell, WH
Poole, GC
Valett, HM
Arango, CP
Bernot, MJ
Burgin, AJ
Crenshaw, CL
Helton, AM
Johnson, LT
O'Brien, JM
Potter, JD
Sheibley, RW
Sobota, DJ
Thomas, SM
AF Beaulieu, Jake J.
Tank, Jennifer L.
Hamilton, Stephen K.
Wollheim, Wilfred M.
Hall, Robert O., Jr.
Mulholland, Patrick J.
Peterson, Bruce J.
Ashkenas, Linda R.
Cooper, Lee W.
Dahm, Clifford N.
Dodds, Walter K.
Grimm, Nancy B.
Johnson, Sherri L.
McDowell, William H.
Poole, Geoffrey C.
Valett, H. Maurice
Arango, Clay P.
Bernot, Melody J.
Burgin, Amy J.
Crenshaw, Chelsea L.
Helton, Ashley M.
Johnson, Laura T.
O'Brien, Jonathan M.
Potter, Jody D.
Sheibley, Richard W.
Sobota, Daniel J.
Thomas, Suzanne M.
TI Nitrous oxide emission from denitrification in stream and river networks
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
ID HEADWATER STREAMS; NITRATE REMOVAL; FRESH-WATER; N2O; ECOSYSTEMS; SOILS;
ABUNDANCE; OXYGEN; RATES; CYCLE
AB Nitrous oxide (N2O) is a potent greenhouse gas that contributes to climate change and stratospheric ozone destruction. Anthropogenic nitrogen (N) loading to river networks is a potentially important source of N2O via microbial denitrification that converts N to N2O and dinitrogen (N-2). The fraction of denitrified N that escapes as N2O rather than N-2 (i.e., the N2O yield) is an important determinant of how much N2O is produced by river networks, but little is known about the N2O yield in flowing waters. Here, we present the results of whole-stream N-15-tracer additions conducted in 72 headwater streams draining multiple land-use types across the United States. We found that stream denitrification produces N2O at rates that increase with stream water nitrate (NO3-) concentrations, but that <1% of denitrified N is converted to N2O. Unlike some previous studies, we found no relationship between the N2O yield and stream water NO3-. We suggest that increased stream NO3- loading stimulates denitrification and concomitant N2O production, but does not increase the N2O yield. In our study, most streams were sources of N2O to the atmosphere and the highest emission rates were observed in streams draining urban basins. Using a global river network model, we estimate that microbial N transformations (e. g., denitrification and nitrification) convert at least 0.68 Tg.y(-1) of anthropogenic N inputs to N2O in river networks, equivalent to 10% of the global anthropogenic N2O emission rate. This estimate of stream and river N2O emissions is three times greater than estimated by the Intergovernmental Panel on Climate Change.
C1 [Beaulieu, Jake J.; Tank, Jennifer L.] Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USA.
[Hamilton, Stephen K.] Michigan State Univ, Kellogg Biol Stn, Hickory Corners, MI 49060 USA.
[Wollheim, Wilfred M.] Univ New Hampshire, Inst Study Earth Oceans & Space, Complex Syst Res Ctr, Durham, NH 03824 USA.
[Wollheim, Wilfred M.; McDowell, William H.; Potter, Jody D.] Univ New Hampshire, Dept Nat Resources & Environm, Durham, NH 03824 USA.
[Hall, Robert O., Jr.] Univ Wyoming, Dept Zool & Physiol, Laramie, WY 82071 USA.
[Mulholland, Patrick J.] Oak Ridge Natl Lab, Div Environm Sci, Oak Ridge, TN 37831 USA.
[Mulholland, Patrick J.] Univ Tennessee, Dept Ecol & Evolutionary Biol, Knoxville, TN 37996 USA.
[Peterson, Bruce J.; Thomas, Suzanne M.] Marine Biol Lab, Ctr Ecosyst, Woods Hole, MA 02543 USA.
[Ashkenas, Linda R.] Oregon State Univ, Dept Fisheries & Wildlife, Corvallis, OR 97331 USA.
[Cooper, Lee W.] Univ Maryland, Ctr Environm Sci, Chesapeake Biol Lab, Solomons, MD 20688 USA.
[Dahm, Clifford N.; Crenshaw, Chelsea L.] Univ New Mexico, Dept Biol, Albuquerque, NM 87131 USA.
[Dodds, Walter K.] Kansas State Univ, Div Biol, Manhattan, KS 66506 USA.
[Grimm, Nancy B.; Sheibley, Richard W.] Arizona State Univ, Sch Life Sci, Tempe, AZ 85287 USA.
[Johnson, Sherri L.] US Forest Serv, Pacific NW Res Stn, Corvallis, OR 97331 USA.
[Poole, Geoffrey C.] Montana State Univ, Dept Land Resources & Environm Sci, Bozeman, MT 59717 USA.
[Valett, H. Maurice] Virginia Polytech Inst & State Univ, Dept Biol Sci, Blacksburg, VA 24061 USA.
[Arango, Clay P.] Cent Washington Univ, Dept Biol Sci, Ellensburg, WA 98926 USA.
[Bernot, Melody J.] Ball State Univ, Dept Biol, Muncie, IN 47306 USA.
[Burgin, Amy J.] Wright State Univ, Dept Earth & Environm Sci, Dayton, OH 45435 USA.
[Helton, Ashley M.] Univ Georgia, Odum Sch Ecol, Athens, GA 30602 USA.
[Johnson, Laura T.] Indiana Univ, Sch Publ & Environm Affairs, Bloomington, IN 47405 USA.
[O'Brien, Jonathan M.] Univ Canterbury, Sch Biol Sci, Christchurch 8014, New Zealand.
[Sobota, Daniel J.] Washington State Univ, Sch Earth & Environm Sci, Vancouver, WA 98686 USA.
RP Beaulieu, JJ (reprint author), US EPA, Cincinnati, OH 45268 USA.
EM beaulieu.jake@epa.gov
RI Mulholland, Patrick/C-3142-2012; Cooper, Lee/E-5251-2012; O'Brien,
Jonathan/G-6786-2012; Grimm, Nancy/D-2840-2009; Burgin, Amy/G-7444-2014;
Arango Lopez, Celso/H-6433-2015; McDowell, William/E-9767-2010; Burgin,
Amy/C-1528-2010
OI Sheibley, Richard/0000-0003-1627-8536; Cooper, Lee/0000-0001-7734-8388;
Grimm, Nancy/0000-0001-9374-660X; Poole, Geoffrey/0000-0002-8458-0203;
Burgin, Amy/0000-0001-8489-4002; Arango Lopez,
Celso/0000-0003-3382-4754; McDowell, William/0000-0002-8739-9047;
Burgin, Amy/0000-0001-8489-4002
FU National Science Foundation [DEB-0111410]; National Science Foundation's
Long Term Ecological Research (NSF-LTER) network
FX We are grateful to N.E. Ostrom for assistance with stable isotope
measurements of N2 and N2O and G. P. Robertson for
comments on the manuscript. We thank the US Forest Service, National
Park Service, and many private landowners for permission to conduct
experiments on their lands. We also acknowledge the many workers who
helped with the Lotic Intersite Nitrogen experiments. Funding for this
research was provided by the National Science Foundation (DEB-0111410).
The National Science Foundation's Long Term Ecological Research
(NSF-LTER) network hosted many of the study sites included in this
research and partially supported several of the authors during the
project. We specifically acknowledge Andrews, Central Arizona-Phoenix,
Coweeta, Kellogg Biological Station, Konza, Luquillo, Plum Island, and
Sevilleta NSF-LTERs for support.
NR 41
TC 141
Z9 158
U1 13
U2 186
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JAN 4
PY 2011
VL 108
IS 1
BP 214
EP 219
DI 10.1073/pnas.1011464108
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 702SG
UT WOS:000285915000042
PM 21173258
ER
PT J
AU Garcia, VC
Gego, E
Lin, S
Pantea, C
Rappazzo, K
Wootten, A
Rao, ST
AF Garcia, Valerie C.
Gego, Edith
Lin, Shao
Pantea, Cristian
Rappazzo, Kristen
Wootten, Adrienne
Rao, S. Trivikrama
TI An evaluation of transported pollution and respiratory-related hospital
admissions in the state of New York
SO ATMOSPHERIC POLLUTION RESEARCH
LA English
DT Article
DE Health effects; Transported ozone; Meteorology; Back-trajectories
ID EASTERN UNITED-STATES; AIR-QUALITY; OZONE; ASSOCIATION; DISEASES;
CHILDREN; EPISODE
AB Human exposure to air pollution transported from the Midwest is evaluated in eight New York State (NYS) regions over ten summers (1997 - 2006) for association with respiratory-related hospital admissions. Days when pollution is transported into the Northeastern United States (U. S.) were identified by using back-trajectories from the eight regions. These back-trajectories help identify predominant meteorological patterns associated with "polluted" air parcels (originating in the Midwest where power plant emissions are known to be relatively high) and "clean" air parcels (originating from the North where pollution is known to be relatively low). Ambient ozone concentrations measurements were used to validate the classification of "polluted" and "clean" air parcels. These classifications were then used to define the days of high-versus low-exposure for populations residing within each region. The results of this analysis indicate that the risk of being hospitalized for respiratory-related illness in NYS is greater on those days when air is transported from the Midwest as compared to days when air is transported from the North. Using a refined method to examine air parcels moving through a boundary drawn around high-emitting power plants in the Midwestern U. S. resulted in stronger associations across more regions (significant odds ratios ranging from 1.06 to 1.16 for the entire study time period for six of the eight NYS regions). An assessment of temperature and its impact on the odds ratio calculation in the New York City metropolitan region indicates that temperature alone does not explain the increased association between air pollution and respiratory-related hospital admissions. (C) Author(s) 2011. This work is distributed under the Creative Commons Attribution 3.0 License.
C1 [Garcia, Valerie C.; Rao, S. Trivikrama] US EPA, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA.
[Gego, Edith] Gego Associates, Idaho Falls, ID USA.
[Lin, Shao; Pantea, Cristian] New York State Dept Hlth, Albany, NY USA.
[Rappazzo, Kristen] Univ N Carolina, Chapel Hill, NC USA.
[Wootten, Adrienne] N Carolina State Univ, Raleigh, NC 27695 USA.
RP Garcia, VC (reprint author), US EPA, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA.
EM garcia.val@epa.gov
OI Lin, Shao/0000-0002-5535-7504
NR 20
TC 10
Z9 10
U1 0
U2 11
PU TURKISH NATL COMMITTEE AIR POLLUTION RES & CONTROL-TUNCAP
PI BUCA
PA DOKUZ EYLUL UNIV, DEPT ENVIRONMENTAL ENGINEERING, TINAZTEPE CAMPUS,
BUCA, IZMIR 35160, TURKEY
SN 1309-1042
J9 ATMOS POLLUT RES
JI Atmos. Pollut. Res.
PD JAN
PY 2011
VL 2
IS 1
BP 9
EP 15
DI 10.5094/APR.2011.002
PG 7
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 029QI
UT WOS:000310510200002
ER
PT J
AU Liu, P
Zhang, Y
Yu, SC
Schere, KL
AF Liu, Ping
Zhang, Yang
Yu, Shaocai
Schere, Kenneth L.
TI Use of a process analysis tool for diagnostic study on fine particulate
matter predictions in the U.S. - Part II: Analyses and sensitivity
simulations
SO ATMOSPHERIC POLLUTION RESEARCH
LA English
DT Article
DE Fine Particulate Matter; CMAQ; Process Analysis; Sensitivity Study; 1999
SOS
ID AIR-QUALITY MODEL; DRY DEPOSITION; NORTH-CAROLINA; UNITED-STATES; OZONE;
CHEMISTRY; INDICATORS; AMMONIA; EMISSIONS; SURFACE
AB Following the Part I paper that describes an application of the U. S. EPA Models-3/Community Multiscale Air Quality (CMAQ) modeling system to the 1999 Southern Oxidants Study episode, this paper presents results from process analysis (PA) using the PA tool embedded in CMAQ and subsequent sensitivity simulations to estimate the impacts of major model uncertainties identified through PA. Aerosol processes and emissions are the most important production processes for PM2.5 and its secondary components, while horizontal and vertical transport and dry deposition contribute to their removal. Cloud processes can contribute the production of PM2.5 and SO42- and the removal of NO3 and NH4+. The model biases between observed and simulated concentrations of PM2.5 and its secondary inorganic components are found to correlate with aerosol processes and dry deposition at all sites from all networks and sometimes with emissions and cloud processes at some sites. Guided with PA results, specific uncertainties examined include the dry deposition of PM2.5 species and its precursors, the emissions of PM2.5 precursors, the cloud processes of SO42-, and the gas-phase oxidation of SO2. Adjusting the most influential processes/factors (i.e., emissions of NH3 and SO2, dry deposition velocity of HNO3, and gas-phase oxidation of SO2 by OH) is found to improve the model overall performance in terms of SO42-, NO3-, and NH4+ predictions. (C) Author(s) 2011. This work is distributed under the Creative Commons Attribution 3.0 License.
C1 [Liu, Ping; Zhang, Yang] N Carolina State Univ, Dept Marine Earth & Atmospher Sci, Raleigh, NC 27695 USA.
[Liu, Ping] Shanghai Jiao Tong Univ, Sch Environm Sci & Engn, Shanghai 200030, Peoples R China.
[Yu, Shaocai; Schere, Kenneth L.] US EPA, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA.
RP Zhang, Y (reprint author), N Carolina State Univ, Dept Marine Earth & Atmospher Sci, Box 8208, Raleigh, NC 27695 USA.
EM yang_zhang@ncsu.edu
RI yu, shaocai/G-7806-2011; yu, shaocai/F-1394-2014
FU National Science Foundation [Atm-0348819]; U.S. Environmental Protection
Agency (EPA) [DW13921548]; U.S. Department of Commerce's National
Oceanic and Atmospheric Administration (NOAA) [DW13921548]
FX This work was performed under the National Science Foundation Award No.
Atm-0348819, and the Memorandum of Understanding between the U.S.
Environmental Protection Agency (EPA) and the U.S. Department of
Commerce's National Oceanic and Atmospheric Administration (NOAA) and
under agreement number DW13921548. The authors thank Alice Gilliland and
Steve Howard, U.S. NOAA/EPA, for providing the Fortran code for
extracting data from CMAQ and the CASTNET, IMPROVE, and AIRS-AQS
observational datasets, and Robert W. Pinder and Prakash Bhave, U.S.
NOAA/EPA, for helpful discussions. Although this work was reviewed by
EPA and approved for publication, it does not necessarily reflect their
policies or views.
NR 29
TC 9
Z9 10
U1 3
U2 17
PU TURKISH NATL COMMITTEE AIR POLLUTION RES & CONTROL-TUNCAP
PI BUCA
PA DOKUZ EYLUL UNIV, DEPT ENVIRONMENTAL ENGINEERING, TINAZTEPE CAMPUS,
BUCA, IZMIR 35160, TURKEY
SN 1309-1042
J9 ATMOS POLLUT RES
JI Atmos. Pollut. Res.
PD JAN
PY 2011
VL 2
IS 1
BP 61
EP 71
DI 10.5094/APR.2011.008
PG 11
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 029QI
UT WOS:000310510200008
ER
PT J
AU Pleim, JE
AF Pleim, Jonathan E.
TI Comment on "Simulation of Surface Ozone Pollution in the Central Gulf
Coast Region Using WRF/Chem Model: Sensitivity to PBL and Land Surface
Physics"
SO ADVANCES IN METEOROLOGY
LA English
DT Letter
ID ATMOSPHERIC BOUNDARY-LAYER; NONLOCAL CLOSURE-MODEL; SYSTEM
AB A recently published meteorology and air quality modeling study has several serious deficiencies deserving comment. The study uses the weather research and forecasting/chemistry (WRF/Chem) model to compare and evaluate boundary layer and land surface modeling options. The most serious of the study's deficiencies is reporting WRF/Chem results for both meteorological and chemical quantities using the asymmetric convective model version 2 (ACM2). While the ACM2 is a valid model option for WRF, it has not yet been implemented for the chemical portion of the WRF/Chem model. Hence, the reported air quality modeling results using ACM2 are invalid. Furthermore, publication of these results gives the erroneous impression that the ACM2 model is not well suited for air quality applications when, in fact, it is the default boundary layer model in the community multiscale air quality (CMAQ) model.
C1 US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Pleim, JE (reprint author), US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
EM pleim.jon@epa.gov
RI Pleim, Jonathan Pleim/C-1331-2017
OI Pleim, Jonathan Pleim/0000-0001-6190-6082
NR 12
TC 4
Z9 4
U1 2
U2 16
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1687-9309
J9 ADV METEOROL
JI Adv. Meteorol.
PY 2011
AR 464753
DI 10.1155/2011/464753
PG 3
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 978NM
UT WOS:000306749800012
ER
PT S
AU Zhang, R
Tafuri, AN
Field, R
Yu, SL
Zhou, WB
Zhang, H
AF Zhang, Ru
Tafuri, Anthony N.
Field, Richard
Yu, Shaw L.
Zhou, Wenbin
Zhang, Hao
BE Zhao, JY
TI Innovative Stormwater Treatment Implementation at Parking Lot in China
SO ADVANCES IN CIVIL ENGINEERING, PTS 1-6
SE Advanced Materials Research
LA English
DT Proceedings Paper
CT International Conference on Civil Engineering and Building Materials
(CEBM)
CY JUL 29-31, 2011
CL Kunming, PEOPLES R CHINA
SP Kunming Univ Sci & Technol, Int Assoc Sci & High Technol
DE Stormwater; Non-point Source Pollution (NPS); Best Management Practices
(BMPs); Low Impact Development (LID); BioBox; Parking Lot
AB Xikeng Reservoir is one of the major water supply reservoirs in Shenzhen. The water quality of Xikeng Reservoir has been poor, with much of the pollution coming from nonpoint sources. An innovative low impact development type of BMP called the BioBox was used at the Administration Building parking lot location, as a research site and demonstration project to show how small alterations to parking lot designs can dramatically decrease pollutant loads. Manual samples were collected during storm events and analyzed for total suspended solids (TSS); five-day biochemical oxygen demand (BOD5); ammonia nitrogen (NH3-N), and total phosphorus (TP). In summary, the ranges of removal rates of the BioBox are: TSS 70% - 90%; BOD5 20% - 50%, and ammonia and phosphorus 30% - 70%. The BioBox system effectively reduced the concentrations of pollutants in the parking lot runoff.
C1 [Zhang, Ru; Zhou, Wenbin; Zhang, Hao] Nanchang Univ, Key Lab Poyang Lake Ecol & Bioresource Utilizat, Sch Environm & Chem Engn, Nanchang 330031, Jiangxi, Peoples R China.
[Tafuri, Anthony N.; Field, Richard] US Environm Protect Agcy, Natl Risk Management Res Lab, Washington, NJ 08837 USA.
[Yu, Shaw L.] Univ Virginia, Dept Civil & Environm Engn, Charlottesville, VA 22904 USA.
RP Zhang, R (reprint author), Nanchang Univ, Key Lab Poyang Lake Ecol & Bioresource Utilizat, Sch Environm & Chem Engn, Nanchang 330031, Jiangxi, Peoples R China.
EM susanzhangru@hotmail.com; Tafuri.Anthony@epa.gov;
Field.Richard@.epa.gov; sly@vua.edu; wbzhou@ncu.edu.cn
NR 6
TC 0
Z9 0
U1 0
U2 7
PU TRANS TECH PUBLICATIONS LTD
PI DURNTEN-ZURICH
PA KREUZSTRASSE 10, 8635 DURNTEN-ZURICH, SWITZERLAND
SN 1022-6680
BN 978-3-03785-139-5
J9 ADV MATER RES-SWITZ
PY 2011
VL 255-260
BP 2718
EP +
DI 10.4028/www.scientific.net/AMR.255-260.2718
PN 1-6
PG 2
WC Construction & Building Technology; Engineering, Civil; Materials
Science, Multidisciplinary
SC Construction & Building Technology; Engineering; Materials Science
GA BZT45
UT WOS:000302894901172
ER
PT J
AU Ekdal, A
Tanik, A
Ambrose, RB
AF Ekdal, A.
Tanik, A.
Ambrose, R. B., Jr.
TI Data inventory and analysis for the application of WASP in a coastal
lagoon
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article; Proceedings Paper
CT 11th International Coastal Symposium (ICS)
CY MAY 09-13, 2011
CL Szczecin, POLAND
SP Univ Szczecin, Inst Marine & Coastal Sci, Coastal Educ & Res Fdn, Univ Szczecinski (US), Cztowiek Nauka Srodowisko (CNS), ZMGM, Reg Dyrekcja Ochrony Srodowiska, Esri, Springer, Lotos, GA2 Syst, World Sci, Helmholtz-Zentrum Geesthacht, Nfosigm, Urzad Marszalkowski Wojewodztwa Zachodniopomorskiego, Wojewodzki Fundusz Ochrony Srodowiska I Gospodarki Wodnej W Gdansku
DE Koycegiz - Dalyan Lagoon; Nutrient modeling; Water quality
AB Ekdal, A., Tanik, A. and Ambrose, Jr, R. B., 2011. Data inventory and analysis for the application of WASP in a coastal lagoon. Journal of Coastal Research, SI 64 (Proceedings of the 11th International Coastal Symposium), 885 - 889. Szczecin, Poland, ISSN 0749-0208
The main objectives of the study were to apply a water quality model to a complex coastal lagoon system, to evaluate its effectiveness, and to prepare guidelines for future water quality modeling studies in such complex systems as well as emphasizing the difficulties faced in developing countries in regard to data availability. Koycegiz - Dalyan Lagoon was selected as the study area that is located at the southwest of Turkey along the Mediterranean Sea Coast. Water Quality Analysis Simulation Program version 7 (WASP7) eutrophication module (WASP/EUTRO) was determined to be the most appropriate model for the area of concern. The lagoon system is divided into 49 longitudinal segments, since horizontal and vertical salinity gradients exist in the system, each longitudinal segment is divided into two as upper and bottom segments; therefore, 98 segments represent the lagoon system. During the water quality modeling study, 4 sets of simulations were conducted sequentially starting from the simplest complexity level to higher complexity levels in order to better understand the processes and mechanisms that occur in the system. NH3-N, NO3--N, Organic N, Detrital N, PO43--P, Organic P, Detrital P, dissolved oxygen, CBOD, detrital carbon, salinity and phytoplankton were simulated in the study. The approaches taken here could help as a guide and example for other developing countries that aim to conduct water quality modeling studies. The study should encourage researchers to initiate similar modeling studies of other lagoons in the world, where lack of data is considered to be a major handicap.
C1 [Ekdal, A.; Tanik, A.] Istanbul Tech Univ, Dept Environm Engn, TR-34469 Istanbul, Turkey.
[Ambrose, R. B., Jr.] US EPA, Ecosyst Res Div, Athens, GA 30605 USA.
RP Ekdal, A (reprint author), Istanbul Tech Univ, Dept Environm Engn, TR-34469 Istanbul, Turkey.
EM ekdala@itu.edu.tr; tanika@itu.edu.tr; rambrose@alum.mit.edu
NR 11
TC 2
Z9 2
U1 5
U2 18
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PY 2011
SI 64
BP 885
EP 889
PN 1
PG 5
WC Environmental Sciences; Geography, Physical; Geosciences,
Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 926IQ
UT WOS:000302824900181
ER
PT J
AU Smyth, HDC
Martonen, TB
Isaacs, KK
Hickey, AJ
AF Smyth, H. D. C.
Martonen, T. B.
Isaacs, K. K.
Hickey, A. J.
TI Estimation of Particle Deposition in the Airways From Different Inhaler
Formulations Using an In Silico Model
SO KONA POWDER AND PARTICLE JOURNAL
LA English
DT Article
DE Aerosol; Metered dose inhalers; hydrofluoroalkane; pMDI; in silico;
prediction
ID METERED-DOSE INHALER; TRACHEOBRONCHIAL TREE; RESPIRATORY-TRACT;
BECLOMETHASONE; SIZE
AB The objective of these studies was to evaluate the use of an in silico model for predicting lung deposition of inhaled therapeutic aerosols. A range of input data derived from our own in vitro data and published clinical studies was utilized. The in silico model ran simulations for these propellant driven metered dose inhaler formulations across a range of conditions. Firstly, a range of pressurized metered dose inhaler formulations were evaluated in the in silico model and compared to the in vitro aerosol performance data. Limitations of using in vitro cascade impaction data were observed. Then, using in vivo data from healthy human subjects using metered dose inhalers, lung deposition profiles were compared with the in silico model predictions. Despite differences in oropharyngeal deposition the model predicted lung deposition accurately. We conclude that the in silico model can be applied to various conditions for particulate based inhalation aerosol systems.
C1 [Smyth, H. D. C.] Univ Texas Austin, Coll Pharm, Austin, TX 78712 USA.
[Isaacs, K. K.] US EPA, Res Triangle Pk, NC 27711 USA.
[Hickey, A. J.] Univ N Carolina, Eshelman Sch Pharm, Chapel Hill, NC USA.
RP Smyth, HDC (reprint author), Univ Texas Austin, Coll Pharm, Austin, TX 78712 USA.
EM hsmyth@mail.utexas.edu
OI Smyth, Hugh/0000-0002-6582-5869
FU NHEERL-UNC DESE [EPA CT829471]; U.S. Environmental Protection Agency
FX Disclaimer: K. K. Isaacs was supported by NHEERL-UNC DESE Cooperative
training agreement in Environmental Sciences Research, EPA CT829471. The
information in this document has been funded wholly (or in part) by the
U.S. Environmental Protection Agency. Its contents are solely the
responsibility of the authors and do not necessarily represent official
views of the agency. The paper has been subjected to the agency's review
process and has been approved for publication. Mention of trade names or
commercial products does not constitute an endorsement or recommendation
for use.
NR 24
TC 0
Z9 0
U1 0
U2 6
PU HOSOKAWA POWDER TECHNOL FOUNDATION
PI HIRAKATA-SHI
PA NO 9, 1-CHOME, SHOUDAI TAJIKA, HIRAKATA-SHI, OSAKA 573-1132, JAPAN
SN 0288-4534
J9 KONA POWDER PART J
JI KONA Powder Part. J.
PY 2011
IS 29
BP 107
EP 117
PG 11
WC Engineering, Chemical; Materials Science, Multidisciplinary
SC Engineering; Materials Science
GA 923LX
UT WOS:000302621900011
ER
PT S
AU Stokes, WS
AF Stokes, William S.
GP Annals NY Acad Sci
TI Best practices for the use of animals in toxicological research and
testing
SO ANIMAL MODELS: THEIR VALUE IN PREDICTING DRUG EFFICACY AND TOXICITY
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT Conference on Animal Models and Their Value in Predicting Drug Efficacy
and Toxicity
CY SEP 15-16, 2011
CL New York, NY
DE toxicology; animal welfare; animal models; alternative methods
AB Animal models serve an important role in assessing preclinical safety and efficacy of new medicines and vaccines; however, such assessments can involve significant pain and distress and large numbers of animals. Best practice approaches seek to enhance animal well-being, minimize or avoid pain and distress, and use fewer animals. Advances in science and technology are providing opportunities for improved mechanism-based models and integrated safety assessments that will support improved animal welfare and reduce animal use.
C1 Natl Inst Environm Hlth Sci, Natl Toxicol Program Interagency Ctr Evaluat Alte, Div Natl Toxicol Program, NIH, Res Triangle Pk, NC 27709 USA.
RP Stokes, WS (reprint author), Natl Inst Environm Hlth Sci, Natl Toxicol Program Interagency Ctr Evaluat Alte, Div Natl Toxicol Program, NIH, POB 12233,Maildrop K2-16,111 TW Alexander Dr, Res Triangle Pk, NC 27709 USA.
EM Stokes@niehs.nih.gov
NR 9
TC 8
Z9 8
U1 2
U2 11
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
BN 978-1-57331-875-4
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2011
VL 1245
BP 17
EP 20
DI 10.1111/j.1749-6632.2011.06334.x
PG 4
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA BZE80
UT WOS:000301289400007
PM 22211968
ER
PT J
AU Ke, HN
Zhang, JY
Akiyama, SK
French, JE
AF Ke, Hengning
Zhang, Jennifer Y.
Akiyama, Steven K.
French, John E.
TI BCL2 interaction with actin in vitro may inhibit cell motility by
enhancing actin polymerization
SO CELL ADHESION & MIGRATION
LA English
DT Article
DE BCL2; actin polymerization; cell motility; adhesion
ID MAMMARY EPITHELIAL-CELLS; TRANSGENIC MICE; ADHESION; EXPRESSION;
OVEREXPRESSION; APOPTOSIS; PROMOTES; SURVIVAL; DIFFERENTIATION;
LAMELLIPODIA
AB In addition to its well-defined role as an antagonist in apoptosis, we propose that BCL2 may act as an intracellular suppressor of cell motility and adhesion under certain conditions. Our evidence shows that, when overexpressed in both cancer and non-cancer cells, BCL2 can form a complex with actin and gelsolin that functions to decrease gelsolin-severing activity to increase actin polymerization and, thus, suppress cell adhesive processes. The linkage between increased BCL2 and increased actin polymerization on the one hand and suppression of cell adhesion, spreading and motility on the other hand, is a novel observation that may provide a plausible explanation for why BCL2 overexpression in some tumors is correlated with improved patient survival. In addition, we have identified conditions in vitro in which F-actin polymerization can be increased while cell motility is reduced. These findings underscore the possibility that BCL2 may be involved in modulating cytoskeleton reorganization and may provide an opportunity to explore signal transduction pathways important for cell adhesion and migration and to develop small molecule therapies for suppression of cancer metastasis.
C1 [French, John E.] Natl Inst Environm Hlth Sci, Host Susceptibil Branch, NIH, Res Triangle Pk, NC 27709 USA.
[Akiyama, Steven K.] Natl Inst Environm Hlth Sci, Lab Mol Carcinogenesis, NIH, Res Triangle Pk, NC USA.
[Ke, Hengning; Zhang, Jennifer Y.] Duke Univ, Med Ctr, Dept Dermatol, Durham, NC USA.
RP French, JE (reprint author), Natl Inst Environm Hlth Sci, Host Susceptibil Branch, NIH, Res Triangle Pk, NC 27709 USA.
EM french@niehs.nih.gov
OI Zhang, Jennifer/0000-0002-4485-1750
FU Division of Intramural Research, NIEHS, NIH; NIAMSD, NIH [K01AR051470]
FX This manuscript was supported by the Division of Intramural Research,
NIEHS, NIH and by NIAMSD, NIH grant K01AR051470 awarded to Dr. Jennifer
Y. Zhang. Thanks to Dr. Douglas S. Tyler, Duke University, Durham, NC
for providing A2058 melanoma cell lines and to Dr. Christine Sorenson,
University of Wisconsin, Madison, WI, for the generous gift of the mouse
Bcl2 deficient cells. We thank Ms. Vineela Gandham for her editing of
this manuscript.
NR 34
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Z9 3
U1 0
U2 4
PU LANDES BIOSCIENCE
PI AUSTIN
PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA
SN 1933-6918
J9 CELL ADHES MIGR
JI Celll Adhes. Migr.
PD JAN-FEB
PY 2011
VL 5
IS 1
BP 6
EP 10
DI 10.4161/cam.5.1.13175
PG 5
WC Cell Biology
SC Cell Biology
GA 898CG
UT WOS:000300712400003
PM 20716950
ER
PT S
AU Srinivasan, RS
Braham, WW
Campbell, DP
Curcija, CD
AF Srinivasan, Ravi S.
Braham, William W.
Campbell, Daniel P.
Curcija, Charlie D.
BE Jain, S
Creasey, R
Himmelspach, J
TI ENERGY BALANCE FRAMEWORK FOR NET ZERO ENERGY BUILDINGS
SO PROCEEDINGS OF THE 2011 WINTER SIMULATION CONFERENCE (WSC)
SE Winter Simulation Conference Proceedings
LA English
DT Proceedings Paper
CT Winter Simulation Conference (WSC)/Conference on Modeling and Analysis
for Semiconductor Manufacturing (MASM)
CY DEC 11-14, 2011
CL Phoenix, AZ
SP Amer Stat Assoc (ASA), Assoc Comp Machinery-Special Interest Grp Simulat (ACM/SIGSIM), Inst Elect & Electron Engineers-Syst, Man, & Cybernet Soc (IEEE/SMC), Inst Ind Engineers (IIE), Inst Operat Res & Management Sci-Simulat Soc (INFORMS-SIM), Natl Inst Stand & Technol (NIST), Soc Modeling & Simulat Int (SCS)
ID EMERGY ANALYSIS
AB Approaching a Net Zero Energy (NZE) building goal based on current definitions is flawed for two principal reasons - they only deal with energy quantities required for operations, and they do not establish a threshold, which ensures that buildings are optimized for reduced consumption before renewable systems are integrated to obtain an energy balance. This paper develops a method to maximize renewable resource use through emergy (spelled with an "m") analysis. A "Renewable Emergy Balance" (REB) in environmental building design is proposed as a tool to maximize renewable resource use through disinvestment of all non-renewable resources that may be substituted with renewable resources. REB buildings attain a high standing by optimizing building construction over their entire life-span from formation-extraction-manufacturing to maintenance and operation, and material reuse at the end of building life-time.
C1 [Srinivasan, Ravi S.] Univ Florida, Coll Design Construct & Planning, ME Rinker Sr Sch Bldg Construct, Gainesville, FL 32611 USA.
[Braham, William W.] Univ Penn, Dept Architecture, Sch Design, Philadelphia, PA 19104 USA.
[Campbell, Daniel P.] US EPA, Off Res & Dev, Natl Hlth & Env, Effects Res Lab,Atlant Ecol Div, Narragansett, RI 02882 USA.
[Curcija, Charlie D.] Lawrence Berkeley Natl Lab, Windows & Daylighting Grp, Building Technologies Dept, Berkeley, CA 94720 USA.
RP Srinivasan, RS (reprint author), Univ Florida, Coll Design Construct & Planning, ME Rinker Sr Sch Bldg Construct, Gainesville, FL 32611 USA.
EM sravi@ufl.edu; brahamw@pobox.upenn.edu; Camp-bell.Dan@epamail.epa.gov;
dccurcija@lbl.gov
NR 26
TC 3
Z9 3
U1 1
U2 4
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 0891-7736
BN 978-1-4577-2109-0
J9 WINT SIMUL C PROC
PY 2011
BP 3360
EP 3372
PG 13
WC Computer Science, Information Systems; Engineering, Electrical &
Electronic; Operations Research & Management Science
SC Computer Science; Engineering; Operations Research & Management Science
GA BYU80
UT WOS:000300520803057
ER
PT J
AU Yttri, KE
Simpson, D
Nojgaard, JK
Kristensen, K
Genberg, J
Stenstrom, K
Swietlicki, E
Hillamo, R
Aurela, M
Bauer, H
Offenberg, JH
Jaoui, M
Dye, C
Eckhardt, S
Burkhart, JF
Stohl, A
Glasius, M
AF Yttri, K. E.
Simpson, D.
Nojgaard, J. K.
Kristensen, K.
Genberg, J.
Stenstrom, K.
Swietlicki, E.
Hillamo, R.
Aurela, M.
Bauer, H.
Offenberg, J. H.
Jaoui, M.
Dye, C.
Eckhardt, S.
Burkhart, J. F.
Stohl, A.
Glasius, M.
TI Source apportionment of the summer time carbonaceous aerosol at Nordic
rural background sites
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID SECONDARY ORGANIC AEROSOL; BOREAL FOREST AEROSOLS; PARTICULATE MATTER;
WOOD COMBUSTION; ATMOSPHERIC AEROSOLS; MASS-SPECTROMETRY; ELEMENTAL
CARBON; AMBIENT AEROSOL; MONOSACCHARIDE ANHYDRIDES; PHOTOCHEMICAL
OXIDATION
AB In the present study, natural and anthropogenic sources of particulate organic carbon (OCp) and elemental carbon (EC) have been quantified based on weekly filter samples of PM10 (particles with aerodynamic diameter < 10 mu m) collected at four Nordic rural background sites [Birkenes (Norway), Hyytiala (Finland), Vavihill (Sweden), Lille Valby, (Denmark)] during late summer (5 August-2 September 2009). Levels of source specific tracers, i.e. cellulose, levoglucosan, mannitol and the C-14/C-12 ratio of total carbon (TC), have been used as input for source apportionment of the carbonaceous aerosol, whereas Latin Hypercube Sampling (LHS) was used to statistically treat the multitude of possible combinations resulting from this approach.
The carbonaceous aerosol (here: TCp; i.e. particulate TC) was totally dominated by natural sources (69-86%), with biogenic secondary organic aerosol (BSOA) being the single most important source (48-57%). Interestingly, primary biological aerosol particles (PBAP) were the second most important source (20-32%). The anthropogenic contribution was mainly attributed to fossil fuel sources (OCff and ECff) (10-24%), whereas no more than 3-7% was explained by combustion of biomass (OCbb and ECbb) in this late summer campaign i.e. emissions from residential wood burning and/or wild/agricultural fires. Fossil fuel sources totally dominated the ambient EC loading, which accounted for 4-12% of TCp, whereas < 1.5% of EC was attributed to combustion of biomass. The carbonaceous aerosol source apportionment showed only minor variation between the four selected sites. However, Hyytiala and Birkenes showed greater resemblance to each other, as did Lille Valby and Vavihill, the two latter being somewhat more influenced by anthropogenic sources.
Ambient levels of organosulphates and nitrooxy-organosulphates in the Nordic rural background environment are reported for the first time in the present study. The most abundant organosulphate compounds were an organosulphate of isoprene and nitrooxy-organosulphates of alpha- and beta-pinene and limonene.
C1 [Yttri, K. E.; Dye, C.; Eckhardt, S.; Burkhart, J. F.; Stohl, A.] Norwegian Inst Air Res, NILU, Kjeller, Norway.
[Simpson, D.] Norwegian Meteorol Inst, EMEP MSC W, Oslo, Norway.
[Simpson, D.] Chalmers, Dept Earth & Space Sci, S-41296 Gothenburg, Sweden.
[Nojgaard, J. K.] Aarhus Univ, Dept Environm Sci, Roskilde, Denmark.
[Stenstrom, K.] Aarhus Univ, Dept Chem, DK-8000 Aarhus, Denmark.
[Genberg, J.; Stenstrom, K.; Swietlicki, E.] Lund Univ, Dept Phys, Div Nucl Phys, Lund, Sweden.
[Hillamo, R.; Aurela, M.] Finnish Meteorol Inst, FIN-00101 Helsinki, Finland.
[Bauer, H.] Vienna Univ Technol, A-1040 Vienna, Austria.
[Offenberg, J. H.] US EPA, Res Triangle Pk, NC 27711 USA.
[Jaoui, M.] Alion Sci & Technol, Res Triangle Pk, NC 27711 USA.
RP Yttri, KE (reprint author), Norwegian Inst Air Res, NILU, Kjeller, Norway.
EM key@nilu.no
RI Simpson, David/A-3313-2009; Stohl, Andreas/A-7535-2008; Yttri, Karl
Espen/E-6671-2012; Offenberg, John/C-3787-2009; Swietlicki,
Erik/B-9426-2014; Eckhardt, Sabine/I-4001-2012
OI Simpson, David/0000-0001-9538-3208; Stohl, Andreas/0000-0002-2524-5755;
Burkhart, John/0000-0002-5587-1693; Glasius,
Marianne/0000-0002-4404-6989; Offenberg, John/0000-0002-0213-4024;
Eckhardt, Sabine/0000-0001-6958-5375
FU Climate and Air Quality Group; EU [036833-2, RII3-CT-2006-026140];
VILLUM FOUNDATION; UNECE; Norwegian Climate and Pollution Agency;
[EP-D-05-065]
FX This work was supported by Nordic Council of Ministers, the Climate and
Air Quality Group, the EU 6th framework EUCAARI (Contract 036833-2), the
VILLUM FOUNDATION and UNECE (the EMEP project). Monitoring of EC/OC at
Birkenes was supported by the Norwegian Climate and Pollution Agency,
the EU 6th framework EUSAAR (Contract No. RII3-CT-2006-026140). The US
Environmental Protection Agency through its Office of Research and
Development collaborated in the research described here through Contract
EP-D-05-065 to Alion Science and Technology. The manuscript has been
subjected to internal peer review and has been cleared for publication.
NR 84
TC 35
Z9 35
U1 0
U2 48
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2011
VL 11
IS 24
BP 13339
EP 13357
DI 10.5194/acp-11-13339-2011
PG 19
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 870KH
UT WOS:000298667600044
ER
PT J
AU Sweeney, K
AF Sweeney, Kevin
BE Dhang, P
TI Present and Future Approaches to Urban Pest Management: a Global
Pesticide Regulatory Perspective
SO URBAN PEST MANAGEMENT: AN ENVIRONMENTAL PERSPECTIVE
LA English
DT Article; Book Chapter
ID WOLBACHIA INFECTION; MOSQUITO
AB Global demand for pesticide products characterized by low toxicity, short residual life and an increased specificity for the pest(s) is increasing. At the same time, the public desire for highly efficacious products that can eliminate pests efficiently, but without pesticides, or with the use of only 'green' products, is at its height. Future pest control solutions will not come solely from conventional pesticides and/or green pest management practices but also from advances in biotechnology and new applications for nanoparticles. This new paradigm brings challenges to regulatory systems, pesticide developers and pesticide applicators during a time when the emergence and resurgence of urban pest problems and vector-borne diseases throughout the world is intensifying. Precaution will be the underlying theme of pesticide legislative mandates and regulatory agencies, which will take a more conservative approach to pesticide risk and exposure assessments where uncertainty exists. Risks to vulnerable populations such as children and the elderly will be emphasized. Shifts towards precautionary principles will make benefit assessments essential, together with research to support the continued use of pest control products and methods. There is an immediate need to develop benefit models for the control of urban pests. Urban pest management programmes must emphasize sustainable practices that include new approaches, technologies and strategies, and integrated pest or vector management principles and practices to help reduce risks in order to satisfy possible future regulatory mandates. This chapter discusses outlooks and trends for pest management and regulatory policy, and suggests recommendations for meeting future challenges.
C1 US EPA, Off Pesticide Programs, Registrat Div 7505P, Washington, DC 20460 USA.
RP Sweeney, K (reprint author), US EPA, Off Pesticide Programs, Registrat Div 7505P, 1200 Penn Ave NW, Washington, DC 20460 USA.
EM sweeney.kevin@epa.gov
NR 90
TC 1
Z9 1
U1 4
U2 10
PU CABI PUBLISHING-C A B INT
PI WALLINGFORD
PA CABI PUBLISHING, WALLINGFORD 0X10 8DE, OXON, ENGLAND
BN 978-1-84593-803-1
PY 2011
BP 207
EP 236
D2 10.1079/9781845938031.0000
PG 30
WC Entomology
SC Entomology
GA BYO42
UT WOS:000299501900015
ER
PT J
AU Ingwersen, W
Young, D
Cabezas, H
Gonzalez, M
Smith, R
AF Ingwersen, Wesley
Young, Douglas
Cabezas, Heriberto
Gonzalez, Michael
Smith, Raymond
GP IEEE
TI Sustainable Supply Chain Design for Consumer Products
SO 2011 IEEE INTERNATIONAL SYMPOSIUM ON SUSTAINABLE SYSTEMS AND TECHNOLOGY
(ISSST)
LA English
DT Proceedings Paper
CT IEEE International Symposium on Sustainable Systems and Technology
(ISSST)
CY MAY 16-18, 2011
CL Chicago, IL
SP IEEE, IEEE Comp Soc Tech Comm Sustainable Syst & Technol, Green Elect Council, EPEAT
C1 [Ingwersen, Wesley; Young, Douglas; Cabezas, Heriberto; Gonzalez, Michael; Smith, Raymond] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Ingwersen, W (reprint author), US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-61284-394-0
PY 2011
PG 1
WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA BXX53
UT WOS:000297353100025
ER
PT J
AU Hughes, BB
Haskins, JC
Wasson, K
Watson, E
AF Hughes, Brent B.
Haskins, John C.
Wasson, Kerstin
Watson, Elizabeth
TI Identifying factors that influence expression of eutrophication in a
central California estuary
SO MARINE ECOLOGY PROGRESS SERIES
LA English
DT Article
DE Eutrophication; Elkhorn Slough; Hypoxia; Environmental filters; Tidal
range; Ulva; Chl a
ID GLOBAL NITROGEN-CYCLE; CHESAPEAKE BAY; PHYTOPLANKTON BIOMASS; SALT
MARSHES; CONSEQUENCES; HYPOXIA; SEA; ECOSYSTEMS; PROFILES; TRENDS
AB Coastal eutrophication models have proposed that various environmental conditions can serve as filters mediating the effects of nutrient loading on coastal ecosystems. Variation in such filters due to natural or anthropogenic causes can potentially lead to varied responses in overall eutrophication expression as well as in individual eutrophication indicators. In this study, we sought to identify factors that affect eutrophication expression at contrasting sites within one nutrient-loaded estuary in central California. We developed and applied a eutrophication expression index to 18 sites in the Elkhorn Slough estuary and then used principal components analysis of environmental drivers (nutrients) and filters to determine how they relate to overall eutrophication expression as well as to individual eutrophication indicators. We also examined the relationship between one key filter, tidal range, and eutrophication indicators. Elkhorn Slough was determined to be a moderately eutrophic estuary, with individual sites varying from being low to hypereutrophic. Eutrophication expression was explained mostly by tidal range, depth, temperature, salinity, distance to estuary mouth, and turbidity, but not by nutrient concentrations. Tidal range in particular correlated strongly with most eutrophication indicators. Sites with artificially dampened tidal range through water control structures were more eutrophic than sites with full tidal exchange. Results from this study emphasize the importance of filters in mediating the negative ecological effects of eutrophication. Coastal managers can decrease eutrophication expression at a local scale by managing for filters (e. g. increasing tidal exchange to managed wetlands), complementing efforts to reduce eutrophication at a regional scale by decreasing nutrient loading.
C1 [Hughes, Brent B.; Haskins, John C.; Wasson, Kerstin; Watson, Elizabeth] Elkhorn Slough Natl Estuarine Res Reserve, Watsonville, CA 95076 USA.
[Hughes, Brent B.; Wasson, Kerstin] Univ Calif Santa Cruz, Dept Ecol & Evolutionary Biol, Santa Cruz, CA 95064 USA.
[Watson, Elizabeth] US EPA, ORD NHEERL, Atlantic Ecol Div, Narragansett, RI 02882 USA.
RP Hughes, BB (reprint author), Elkhorn Slough Natl Estuarine Res Reserve, Watsonville, CA 95076 USA.
EM bbhughes@ucsc.edu
FU Monterey County Water Resources Agency (MCWRA); PG&E special projects
non-point source pollution grant; Elkhorn Slough Foundation; Central
Coast Regional Water Quality Control Board; California Environmental
Protection Agency; Monterey Community Foundation [20060387]; Estuarine
Reserve division of the NOAA
FX We thank E. Van Dyke for spatial analyses; K. Coale and N. Welschmeyer
for use of facilities; S. Tanner for nutrient analysis at Moss Landing
Marine Labs; S. Bricker and J. Ferreira for advice on generating the
EEI; R. Eby, S. Shaw, J. Hatfield, R. Priesler, and P. Brown for
volunteer field support; K. Johnson and J. Plant at the MBARI LOBO
program for additional data; W. M. Kemp, R. Preisler, P. Raimondi, and 4
anonymous reviewers for extensive suggestions that greatly strengthened
the manuscript and improved Fig. 1; and K. Thomasberg and the Monterey
County Water Resources Agency (MCWRA) for long-term financial support
for nutrient analyses. This work was funded as part of a PG&E special
projects non-point source pollution grant with the Elkhorn Slough
Foundation, Central Coast Regional Water Quality Control Board,
California Environmental Protection Agency and the Monterey Community
Foundation (Grant # 20060387). This study was also supported by a grant
from the Estuarine Reserve division of the NOAA.
NR 65
TC 12
Z9 12
U1 6
U2 77
PU INTER-RESEARCH
PI OLDENDORF LUHE
PA NORDBUNTE 23, D-21385 OLDENDORF LUHE, GERMANY
SN 0171-8630
J9 MAR ECOL PROG SER
JI Mar. Ecol.-Prog. Ser.
PY 2011
VL 439
BP 31
EP U71
DI 10.3354/meps09295
PG 25
WC Ecology; Marine & Freshwater Biology; Oceanography
SC Environmental Sciences & Ecology; Marine & Freshwater Biology;
Oceanography
GA 835WR
UT WOS:000296068200003
ER
PT J
AU Ali, G
AF Ali, Ghulam
TI ARCH, GARCH, and ARMAX Models for Forecasting Pathogen Indicators and
Advisories at Marine Recreational Sites
SO MARINE RESOURCE ECONOMICS
LA English
DT Article
DE Autoregressive; moving average; ARMAX; ARCH; AR-ARCH; GARCH; pathogens;
Huntington Beach
AB Despite the wide ranging applications of time series methodologies for stochastic processes, they have not been used for environmental economics (except climate change). To fill this gap, we introduce time series methodology for the environmental econometrics, presenting autoregressive, moving average, ARCH, GARCH, and ARMAX models. These models are applied to establish a functional relationship between pathogen indicator and meteorological and environmental variables using time series data associated with Huntington Beach, Ohio. According to ARCH, turbidity, dew point, flow, and rainfall are statistically significant variables. Other models produced roughly similar results because of the short lag order Models confirm the lag order of one using Akaike, Schwartz, and Hannan-Quinn selection criteria, reflecting very short memory of the pathogen indicator series. However, the time series did not support GARCH variance structure. These models not only under forecasted observations at both ends of the distribution of the data, but also simultaneously underforecasted advisories.
C1 US EPA, Off Water, Off Sci & Technol, Stand & Hlth Protect Div 4305T, Washington, DC 20460 USA.
RP Ali, G (reprint author), US EPA, Off Water, Off Sci & Technol, Stand & Hlth Protect Div 4305T, 1200 Penn Ave NW, Washington, DC 20460 USA.
EM ali.ghulam@epa.gov
NR 13
TC 3
Z9 3
U1 0
U2 2
PU MRE FOUNDATION, INC
PI KINGSTON
PA PO BOX 1828, KINGSTON, RI 02881 USA
SN 0738-1360
J9 MAR RESOUR ECON
JI Mar. Resour. Econ.
PY 2011
VL 26
IS 3
BP 211
EP 224
PG 14
WC Economics; Environmental Studies; Fisheries
SC Business & Economics; Environmental Sciences & Ecology; Fisheries
GA 831DS
UT WOS:000295709500003
ER
PT B
AU Hidy, GM
Brook, JR
Demerjian, KL
Molina, LT
Scheffe, RD
AF Hidy, George M.
Brook, Jeffrey R.
Demerjian, Kenneth L.
Molina, Luisa T.
Scheffe, Richard D.
BE Hidy, GM
Brook, JR
Demerjian, KL
Molina, LT
Pennell, WT
Scheffe, RD
TI Technical Challenges of Multipollutant Air Quality Management
Introduction
SO TECHNICAL CHALLENGES OF MULTIPOLLUTANT AIR QUALITY MANAGEMENT
LA English
DT Editorial Material; Book Chapter
C1 [Hidy, George M.] Envair Aerochem, Placitas, NM 87043 USA.
[Brook, Jeffrey R.] Environm Canada, Downsview, ON M3H 5T4, Canada.
[Demerjian, Kenneth L.] SUNY Albany, Atmospher Sci Res Ctr, CESTM, Albany, NY 12203 USA.
[Molina, Luisa T.] MIT, La Jolla, CA 92037 USA.
[Molina, Luisa T.] Molina Ctr Energy & Environm, La Jolla, CA 92037 USA.
[Scheffe, Richard D.] US EPA, Res Triangle Pk, NC 27711 USA.
RP Hidy, GM (reprint author), Envair Aerochem, 6 Evergreen Dr, Placitas, NM 87043 USA.
EM dhidy113@comcast.net; jeff.brook@ec.gc.ca; kld@asrc.cestm.albany.edu;
ltmolina@mit.edu; scheffe.rich@epa.gov; dhidy113@comcast.net;
jeff.brook@ec.gc.ca; kld@asrc.cestm.albany.edu; ltmolina@mit.edu;
scheffe.rich@epa.gov
NR 2
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
BN 978-94-007-0303-2
PY 2011
BP 19
EP 22
DI 10.1007/978-94-007-0304-9_2
D2 10.1007/978-94-007-0304-9
PG 4
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA BWM39
UT WOS:000294234100002
ER
PT B
AU Hidy, GM
Brook, JR
Demerjian, KL
Molina, LT
Scheffe, RD
AF Hidy, George M.
Brook, Jeffrey R.
Demerjian, Kenneth L.
Molina, Luisa T.
Scheffe, Richard D.
BE Hidy, GM
Brook, JR
Demerjian, KL
Molina, LT
Pennell, WT
Scheffe, RD
TI Decision-Making Framework for Air Quality Management
SO TECHNICAL CHALLENGES OF MULTIPOLLUTANT AIR QUALITY MANAGEMENT
LA English
DT Article; Book Chapter
ID POLLUTION
C1 [Hidy, George M.] Envair Aerochem, Placitas, NM 87043 USA.
[Molina, Luisa T.] MIT, La Jolla, CA 92037 USA.
[Molina, Luisa T.] Molina Ctr Energy & Environm, La Jolla, CA 92037 USA.
[Scheffe, Richard D.] US EPA, Res Triangle Pk, NC 27711 USA.
[Demerjian, Kenneth L.] SUNY Albany, Atmospher Sci Res Ctr, CESTM, Albany, NY 12203 USA.
[Brook, Jeffrey R.] Environm Canada, Downsview, ON M3H 5T4, Canada.
RP Hidy, GM (reprint author), Envair Aerochem, 6 Evergreen Dr, Placitas, NM 87043 USA.
EM dhidy113@comcast.net; jeff.brook@ec.gc.ca; kld@asrc.cestm.albany.edu;
ltmolina@mit.edu; scheffe.rich@epa.gov; dhidy113@comcast.net;
jeff.brook@ec.gc.ca; kld@asrc.cestm.albany.edu; ltmolina@mit.edu;
scheffe.rich@epa.gov
NR 16
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
BN 978-94-007-0303-2
PY 2011
BP 23
EP 43
DI 10.1007/978-94-007-0304-9_3
D2 10.1007/978-94-007-0304-9
PG 21
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA BWM39
UT WOS:000294234100003
ER
PT B
AU Hubbell, B
Frey, C
AF Hubbell, Bryan
Frey, Chris
BE Hidy, GM
Brook, JR
Demerjian, KL
Molina, LT
Pennell, WT
Scheffe, RD
TI Risk-Based Assessment and Management Framework
SO TECHNICAL CHALLENGES OF MULTIPOLLUTANT AIR QUALITY MANAGEMENT
LA English
DT Article; Book Chapter
ID MEXICO-CITY
C1 [Hubbell, Bryan] US EPA, Res Triangle Pk, NC 27711 USA.
[Frey, Chris] N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA.
RP Hubbell, B (reprint author), US EPA, 109 TW Alexander Dr,Mail Code C504-02, Res Triangle Pk, NC 27711 USA.
EM hubbell.bryan@epa.gov; frey@eos.ncsu.edu
OI Hubbell, Bryan/0000-0002-7963-3438
NR 24
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
BN 978-94-007-0303-2
PY 2011
BP 45
EP 66
DI 10.1007/978-94-007-0304-9_4
D2 10.1007/978-94-007-0304-9
PG 22
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA BWM39
UT WOS:000294234100004
ER
PT B
AU Hidy, GM
Brook, JR
Demerjian, KL
Molina, LT
Scheffe, RD
AF Hidy, George M.
Brook, Jeffrey R.
Demerjian, Kenneth L.
Molina, Luisa T.
Scheffe, Richard D.
BE Hidy, GM
Brook, JR
Demerjian, KL
Molina, LT
Pennell, WT
Scheffe, RD
TI Toward Risk- and Results-Based Multipollutant Air Quality
Management-What's Next?
SO TECHNICAL CHALLENGES OF MULTIPOLLUTANT AIR QUALITY MANAGEMENT
LA English
DT Article; Book Chapter
ID POLLUTION; HEALTH; MORTALITY
C1 [Hidy, George M.] Envair Aerochem, Placitas, NM 87043 USA.
[Brook, Jeffrey R.] Environm Canada, Downsview, ON M3H 5T4, Canada.
[Demerjian, Kenneth L.] SUNY Albany, Atmospher Sci Res Ctr, CESTM, Albany, NY 12203 USA.
[Molina, Luisa T.] MIT, La Jolla, CA 92037 USA.
[Molina, Luisa T.] Molina Ctr Energy & Environm, La Jolla, CA 92037 USA.
[Scheffe, Richard D.] US EPA, Res Triangle Pk, NC 27711 USA.
RP Hidy, GM (reprint author), Envair Aerochem, 6 Evergreen Dr, Placitas, NM 87043 USA.
EM dhidy113@comcast.net; jeff.brook@ec.gc.ca; kld@asrc.cestm.albany.edu;
ltmolina@mit.edu; scheffe.rich@epa.gov; dhidy113@comcast.net;
jeff.brook@ec.gc.ca; kld@asrc.cestm.albany.edu; ltmolina@mit.edu;
scheffe.rich@epa.gov
NR 25
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
BN 978-94-007-0303-2
PY 2011
BP 505
EP 527
DI 10.1007/978-94-007-0304-9_13
D2 10.1007/978-94-007-0304-9
PG 23
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA BWM39
UT WOS:000294234100013
ER
PT B
AU Hidy, GM
Brook, JR
Demerjian, KL
Molina, LT
Scheffe, RI
AF Hidy, George M.
Brook, Jeffrey R.
Demerjian, Kenneth L.
Molina, Luisa T.
Scheffe, Richard I.
BE Hidy, GM
Brook, JR
Demerjian, KL
Molina, LT
Pennell, WT
Scheffe, RD
TI Technical Challenges of Multipollutant Air Quality Management
Conclusions and Recommendations
SO TECHNICAL CHALLENGES OF MULTIPOLLUTANT AIR QUALITY MANAGEMENT
LA English
DT Editorial Material; Book Chapter
C1 [Hidy, George M.] Envair Aerochem, Placitas, NM 87043 USA.
[Brook, Jeffrey R.] Environm Canada, Downsview, ON M3H 5T4, Canada.
[Demerjian, Kenneth L.] SUNY Albany, Atmospher Sci Res Ctr, CESTM, Albany, NY 12203 USA.
[Molina, Luisa T.] MIT, La Jolla, CA 92037 USA.
[Molina, Luisa T.] Molina Ctr Energy & Environm, La Jolla, CA 92037 USA.
[Scheffe, Richard I.] US EPA, Res Triangle Pk, NC 27711 USA.
RP Hidy, GM (reprint author), Envair Aerochem, 6 Evergreen Dr, Placitas, NM 87043 USA.
EM dhidy113@comcast.net; jeff.brook@ec.gc.ca; kld@asrc.cestm.albany.edu;
ltmolina@mit.edu; scheffe.rich@epa.gov; dhidy113@comcast.net;
jeff.brook@ec.gc.ca; kld@asrc.cestm.albany.edu; ltmolina@mit.edu
NR 2
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
BN 978-94-007-0303-2
PY 2011
BP 529
EP 540
DI 10.1007/978-94-007-0304-9_14
D2 10.1007/978-94-007-0304-9
PG 12
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA BWM39
UT WOS:000294234100014
ER
PT S
AU Hemming, BL
Hagler, GSW
AF Hemming, Brooke L.
Hagler, Gayle S. W.
BE Princiotta, FT
TI Geoengineering: Direct Mitigation of Climate Warming
SO GLOBAL CLIMATE CHANGE - THE TECHNOLOGY CHALLENGE
SE Advances in Global Change Research
LA English
DT Article; Book Chapter
ID LEVEL MARITIME CLOUDS; IRON FERTILIZATION; ALBEDO ENHANCEMENT;
ATMOSPHERIC CO2; CARBON; EMISSIONS; OZONE; SINKS; CYCLE; AIR
AB With the concentrations of atmospheric greenhouse gases (GHGs) rising to levels unprecedented in the current glacial epoch, the earth's climate system appears to be rapidly shifting into a warmer regime. Many in the international science and policy communities fear that the fundamental changes in human behavior, and in the global economy, that will be required to meaningfully reduce GHG emissions in the very near term are unattainable. In the 1970s, discussion of "geoengineering," a radical strategy for arresting climate change by intentional, direct manipulation of the Earth's energy balance began to appear in the climate science literature. With growing international concern about the pace of climate change, the scientific and public discourse on the feasibility of geoengineering has recently grown more sophisticated and more energetic. A wide array of potential geoengineering projects have been proposed, ranging from orbiting space mirrors to reduce solar flux to the construction of large networks of processors that directly remove carbon dioxide from the atmosphere. Simple estimates of costs exist, and some discussion of both the potentially negative and "co-beneficial" consequences of these projects can be found in the scientific literature.
The critical, missing piece in the discussion of geoengineering as a strategy for managing climate is an integrated evaluation of the downstream costs-versus-benefits inter-comparing all available climate management options, including geoengineering. Our examination of the literature revealed a number of substantial gaps in the knowledge base required for such an evaluation. Therefore, to ensure that the decision framework arising from this analysis is well founded, a focused program of scientific research to fill those gaps is also essential. As with any sound engineering plan, international decisions on how to address human-induced climate warming must be founded on a thoughtful and well-informed analysis of all of the available options.
C1 [Hemming, Brooke L.; Hagler, Gayle S. W.] US EPA, Air Pollut Prevent & Control Div, Natl Risk Management Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Hemming, BL (reprint author), US EPA, Change Res Program, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
EM hemming.brooke@epa.gov
NR 57
TC 3
Z9 3
U1 2
U2 18
PU SPRINGER
PI DORDRECHT
PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS
SN 1574-0919
BN 978-90-481-3152-5
J9 ADV GLOB CHANGE RES
JI Adv. Glob. Change Res.
PY 2011
VL 38
BP 273
EP 299
DI 10.1007/978-90-481-3153-2_9
D2 10.1007/978-90-481-3153-2
PG 27
WC Energy & Fuels; Environmental Sciences; Environmental Studies
SC Energy & Fuels; Environmental Sciences & Ecology
GA BVY51
UT WOS:000293147500009
ER
PT S
AU Vijay, S
Chikkatur, A
AF Vijay, Samudra
Chikkatur, Ananth
BE Princiotta, FT
TI The Role of Technology in Mitigating Greenhouse Gas Emissions from Power
Sector in Developing Countries: The Case of China, India, and Mexico
SO GLOBAL CLIMATE CHANGE - THE TECHNOLOGY CHALLENGE
SE Advances in Global Change Research
LA English
DT Article; Book Chapter
ID REFORM
AB China, India, and Mexico are among the top developing country emitters of CO2. The electric power sectors in China and India is dominated by coal-fired power plants, whereas fuel oil and natural gas are the key fossil fuels in Mexico. Spurred by economic development and population growth, demand for electricity in these countries is expected to continue to rise. Meeting this increased demand will have a significant impact on emissions of greenhouse gases (GHG). While available portfolio of generation and mitigation technologies may not suffice to arrest the growth of emissions, it can help reduce the rate of emissions growth. To achieve significant reductions, multiple approaches are required, such as reducing demand by adopting end-use efficiency improvement measures, accelerating the deployment of renewable and nuclear power, and adopting cleaner more efficient generation technologies. Retrofitting the existing fleet to meet strengthened environmental standards, and accelerated fleet-turnover, coupled with adoption of state-of-the-art high efficiency generation technologies, such as supercritical and ultra-supercritical boilers and advanced combined-cycle gas turbines, should play an important role in meeting the increasing demand with the least amount of GHG emissions. In parallel, significant R&D efforts will have to be undertaken to adapt off-the-shelf generation technologies to suit local needs. In the medium to long term, developed countries will need to provide financial and technical support for these countries and partner with them to develop, design, demonstrate, and deploy technologies for capturing and sequestering carbon dioxide.
C1 [Vijay, Samudra] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Air Pollut Prevent & Control Div, Res Triangle Pk, NC 27711 USA.
[Vijay, Samudra] Sam Analyt Solut LLC, Morrisville, NC 27560 USA.
[Chikkatur, Ananth] Harvard Univ, John F Kennedy Sch Govt, Belfer Ctr Sci & Int Affairs, Cambridge, MA 02138 USA.
[Chikkatur, Ananth] ICF Int, Fairfax, VA 22031 USA.
RP Vijay, S (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Air Pollut Prevent & Control Div, Res Triangle Pk, NC 27711 USA.
EM sam@samanalyticsolutions.com; ap_chikkatur@yahoo.com
NR 54
TC 0
Z9 0
U1 1
U2 8
PU SPRINGER
PI DORDRECHT
PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS
SN 1574-0919
BN 978-90-481-3152-5
J9 ADV GLOB CHANGE RES
JI Adv. Glob. Change Res.
PY 2011
VL 38
BP 345
EP 375
DI 10.1007/978-90-481-3153-2_11
D2 10.1007/978-90-481-3153-2
PG 31
WC Energy & Fuels; Environmental Sciences; Environmental Studies
SC Energy & Fuels; Environmental Sciences & Ecology
GA BVY51
UT WOS:000293147500011
ER
PT S
AU Miller, CA
Gage, CL
AF Miller, C. Andrew
Gage, Cynthia L.
BE Princiotta, FT
TI Potential Adverse Environmental Impacts of Greenhouse Gas Mitigation
Strategies
SO GLOBAL CLIMATE CHANGE - THE TECHNOLOGY CHALLENGE
SE Advances in Global Change Research
LA English
DT Article; Book Chapter
ID INDOOR-AIR-QUALITY; LIFE-CYCLE; UNITED-STATES; ENGINEERED NANOMATERIALS;
INTEGRATED ASSESSMENT; GENETIC-MODIFICATION; ENERGY-CONSERVATION;
HYDROGEN ECONOMY; GLOBAL CLIMATE; CARBON CAPTURE
AB The Fourth Assessment Report released by the Intergovernmental Panel on Climate Change (IPCC) in 2007 was unequivocal in its message that warming of the global climate system is now occurring, and found, with "very high confidence" that it was "very likely" that the observed warming was due to anthropogenic emissions of greenhouse gases (GHGs). To address the problem, the IPCC developed an outline of approaches to reduce GHG emissions to desired levels. The expected changes in technologies and practices needed to mitigate emissions of GHGs will lead to changes in the impacts to the environment associated with energy production and use. Some of these changes will be beneficial, but others will not. This chapter identifies some of the potential environmental impacts (other than the intended mitigation of climate change) of implementing GHG mitigation strategies, but will not attempt to quantify those impacts or their costs. Included are discussions of the impacts of implementing energy efficiency and conservation measures, fuel switching in the power generation sector, nuclear and renewable energy, carbon capture and storage, use of biofuels and natural gas for transportation fuels, and hydrogen and electricity for transportation energy. Environmental impacts addressed include changes in air emissions of nitrogen oxides, sulfur dioxide, and particulate matter; impacts to water quality and quantity; increased mining of coal to meet the power demands of carbon capture systems and of metals to meet demands for vehicle batteries; and impacts to ecosystems associated with biofuel production and siting of other renewable energy systems.
C1 [Miller, C. Andrew; Gage, Cynthia L.] US EPA, Air Pollut Prevent & Control Div, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
RP Miller, CA (reprint author), US EPA, Air Pollut Prevent & Control Div, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
EM miller.andy@epa.gov
NR 146
TC 1
Z9 1
U1 3
U2 14
PU SPRINGER
PI DORDRECHT
PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS
SN 1574-0919
BN 978-90-481-3152-5
J9 ADV GLOB CHANGE RES
JI Adv. Glob. Change Res.
PY 2011
VL 38
BP 377
EP 415
DI 10.1007/978-90-481-3153-2_12
D2 10.1007/978-90-481-3153-2
PG 39
WC Energy & Fuels; Environmental Sciences; Environmental Studies
SC Energy & Fuels; Environmental Sciences & Ecology
GA BVY51
UT WOS:000293147500012
ER
PT J
AU Krzyzynska, R
Zhao, YX
Hutson, ND
AF Krzyzynska, Renata
Zhao, Yongxin
Hutson, Nick D.
TI Bench- and Pilot-scale Investigation of Integrated Removal of Sulphur
Dioxide, Nitrogen Oxides and Mercury in a Wet Limestone Scrubber
SO ROCZNIK OCHRONA SRODOWISKA
LA English
DT Article
C1 [Krzyzynska, Renata] Wroclaw Univ Technol, PL-50370 Wroclaw, Poland.
[Hutson, Nick D.] US EPA, Res Triangle Pk, NC USA.
RP Krzyzynska, R (reprint author), Wroclaw Univ Technol, PL-50370 Wroclaw, Poland.
FU U.S. EPA (Office of Air and Radiation (OAR)); U.S. EPA (Office of
Research and Development (ORD)); Polish Ministry of Science and Higher
Education
FX This work was supported by funding from the U.S. EPA (Office of Air and
Radiation (OAR) and Office of Research and Development (ORD)) and by
Polish Ministry of Science and Higher Education (by means for scientific
projects in the years 2010 divided by 2012 as a research project).
NR 19
TC 1
Z9 1
U1 1
U2 3
PU MIDDLE POMERANIAN SCI SOC ENV PROT
PI KOSZALIN
PA KOLLATAJA 1-1, KOSZALIN, 75-448, POLAND
SN 1506-218X
J9 ROCZ OCHR SR
JI Rocz. Ochr. Sr.
PY 2011
VL 13
BP 29
EP 49
PN 1
PG 21
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 805WO
UT WOS:000293760100001
ER
PT J
AU Covello, VT
AF Covello, Vincent T.
BE Brenner, GH
Bush, DH
Moses, J
TI Principles of Risk Communication
SO CREATING SPIRITUAL AND PSYCHOLOGICAL RESILIENCE: INTEGRATING CARE IN
DISASTER RELIEF WORK
LA English
DT Article; Book Chapter
ID PERCEPTION
C1 [Covello, Vincent T.] Ctr Risk Commun, New York, NY 10022 USA.
[Covello, Vincent T.] US Ctr Dis Control & Prevent, Atlanta, GA USA.
[Covello, Vincent T.] US EPA, Washington, DC USA.
[Covello, Vincent T.] Columbia Univ, Fac Med, New York, NY USA.
RP Covello, VT (reprint author), Ctr Risk Commun, New York, NY 10022 USA.
NR 37
TC 0
Z9 0
U1 0
U2 2
PU ROUTLEDGE
PI LONDON
PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND
BN 978-0-20386-953-6
PY 2011
BP 39
EP 74
PG 36
WC Psychology, Clinical; Social Work; Religion
SC Psychology; Social Work; Religion
GA BUP96
UT WOS:000290017600006
ER
PT J
AU Ehrenfeld, JG
Palta, M
Stander, E
AF Ehrenfeld, Joan G.
Palta, Monica
Stander, Emilie
BE Douglas, I
Goode, D
Houck, M
Wang, R
TI Wetlands in urban environments
SO ROUTLEDGE HANDBOOK OF URBAN ECOLOGY
LA English
DT Article; Book Chapter
ID CAROLINA COASTAL ESTUARIES; EXOTIC SPECIES INVASION; NORTHEASTERN
NEW-JERSEY; WHITE CEDAR WETLANDS; SALT-MARSH SEDIMENTS; FRESH-WATER
WETLAND; ADJACENT LAND-USE; FORESTED WETLANDS; RIPARIAN FOREST; RURAL
GRADIENT
C1 [Ehrenfeld, Joan G.; Palta, Monica] Rutgers State Univ, Dept Ecol Evolut & Nat Resources, SEBS, New Brunswick, NJ 08901 USA.
[Stander, Emilie] US EPA, Urban Watershed Management Branch, Edison, NJ 08837 USA.
RP Ehrenfeld, JG (reprint author), Rutgers State Univ, Dept Ecol Evolut & Nat Resources, SEBS, 14 Coll Farm Rd, New Brunswick, NJ 08901 USA.
NR 88
TC 0
Z9 0
U1 1
U2 8
PU ROUTLEDGE
PI LONDON
PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND
BN 978-1-13688-341-5
PY 2011
BP 338
EP 351
PG 14
WC Ecology; Environmental Studies; Geography; Urban Studies
SC Environmental Sciences & Ecology; Geography; Urban Studies
GA BUU51
UT WOS:000290380300031
ER
PT J
AU Mahendra, A
AF Mahendra, Anjali
BE Dimitriou, HT
Gakenheimer, R
TI Options for travel demand management: traffic bans versus pricing
SO URBAN TRANSPORT IN THE DEVELOPING WORLD: A HANDBOOK OF POLICY AND
PRACTICE
LA English
DT Article; Book Chapter
ID CITIES
C1 [Mahendra, Anjali] ICF Int, Fairfax, VA 22031 USA.
[Mahendra, Anjali] MIT, Cambridge, MA 02139 USA.
[Mahendra, Anjali] World Bank, Washington, DC USA.
[Mahendra, Anjali] US EPA, Washington, DC USA.
[Mahendra, Anjali] Transportat Res Board, Washington, DC USA.
[Mahendra, Anjali] World Business Council Sustainable Dev, Geneva, Switzerland.
RP Mahendra, A (reprint author), ICF Int, Fairfax, VA 22031 USA.
NR 41
TC 1
Z9 1
U1 0
U2 1
PU EDWARD ELGAR PUBLISHING LTD
PI CHELTENHAM
PA GLENSANDA HOUSE, MONTPELLIER PARADE, CHELTENHAM GL50 1UA, GLOS, ENGLAND
BN 978-1-84720-205-5
PY 2011
BP 519
EP 547
PG 29
WC Transportation; Urban Studies
SC Transportation; Urban Studies
GA BUE17
UT WOS:000288992500019
ER
PT B
AU Johnson, JL
Hrynkow, S
AF Johnson, Joy L.
Hrynkow, Sharon
BE Kirst, M
SchaeferMcDaniel, N
Hwang, S
OCampo, P
TI Funding Agencies and Transdisciplinary Research
SO CONVERGING DISCIPLINES: A TRANSDISCIPLINARY RESEARCH APPROACH TO URBAN
HEALTH PROBLEMS
LA English
DT Article; Book Chapter
C1 [Johnson, Joy L.] Univ British Columbia, Canadian Inst Hlth Res, Inst Gender & Hlth, Vancouver, BC V5Z 1M9, Canada.
[Johnson, Joy L.] Univ British Columbia, Sch Nursing, Vancouver, BC V5Z 1M9, Canada.
[Hrynkow, Sharon] Natl Inst Environm Hlth Sci, NIH, Res Triangle Pk, NC 27709 USA.
RP Johnson, JL (reprint author), Univ British Columbia, Canadian Inst Hlth Res, Inst Gender & Hlth, Vancouver, BC V5Z 1M9, Canada.
NR 8
TC 1
Z9 1
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-6329-1
PY 2011
BP 149
EP 160
DI 10.1007/978-1-4419-6330-7_11
D2 10.1007/978-1-4419-6330-7
PG 12
WC Public, Environmental & Occupational Health; Urban Studies
SC Public, Environmental & Occupational Health; Urban Studies
GA BSN40
UT WOS:000285021000011
ER
PT S
AU Darling, JA
AF Darling, John A.
BE Galil, BS
Clark, PF
Carlton, JT
TI More than One Way to Invade: Lessons from Genetic Studies of Carcinus
Shore Crabs
SO IN THE WRONG PLACE - ALIEN MARINE CRUSTACEANS: DISTRIBUTION, BIOLOGY AND
IMPACTS
SE Invading Nature-Springer Series in Invasion Ecology
LA English
DT Article; Book Chapter
ID EUROPEAN GREEN CRAB; MULTIPLE INTRODUCTIONS; BIOLOGICAL INVASIONS;
POPULATION-GENETICS; MICROSATELLITE LOCI; SPECIES INVASIONS; CRYPTIC
INVASIONS; GENUS CARCINUS; MAENAS; DIVERSITY
AB The European green crab Carcinus maenas is one of the world's most widely recognized marine invaders. The success of this species has provided opportunities to explore genetic patterns associated with establishment and population expansion following independent introduction events to widely different recipient ecosystems. Recent studies have revealed an extraordinary diversity of such patterns. Globally, genetic reconstruction of invasion histories suggests complicated scenarios comprising multiple introductions to some regions as well as secondary introductions deriving from previously established invasive populations. In addition, detailed genetic analyses of several introduced populations indicate that successful invasion may involve rapid expansion from single low diversity founder populations, multiple introductions from genetically distinct sources with subsequent intraspecific admixture, or even interspecific hybridization between C. maenas and its sibling species C. aestuarii. The complexity of this global picture highlights the contingent nature of individual biological invasion events. Nevertheless, genetic study of non-native Carcinus populations provides crucial insights into invasion dynamics relevant to green crab management and control, and offers an unusually rich system within which to explore the genetic consequences of colonizations and range expansions in coastal marine ecosystems.
C1 US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
RP Darling, JA (reprint author), US EPA, Natl Exposure Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM darling.john@epa.gov
NR 68
TC 2
Z9 2
U1 1
U2 9
PU SPRINGER
PI DORDRECHT
PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS
SN 1874-7809
BN 978-94-007-0590-6
J9 INVAD NAT SPRING SER
JI Invading Nat.-Springer Ser. Invasion Ecol.
PY 2011
VL 6
BP 661
EP 685
DI 10.1007/978-94-007-0591-3_24
D2 10.1007/978-94-007-0591-3
PG 25
WC Ecology
SC Environmental Sciences & Ecology
GA BWJ05
UT WOS:000293984800024
ER
PT J
AU Rogers, KR
Gary, RK
AF Rogers, Kim R.
Gary, Ronald K.
BE Mascini, M
Palchetti, I
TI Nucleic Acid-based Biosensors for the Detection of DNA Damage
SO NUCLEIC ACID BIOSENSORS FOR ENVIRONMENTAL POLLUTION MONITORING
LA English
DT Article; Book Chapter
ID GREEN FLUORESCENT PROTEIN; WHOLE-CELL BIOSENSOR; WASTE-WATER SAMPLES;
ESCHERICHIA-COLI; GENOTOXIC COMPOUNDS; TOXICITY ANALYSIS; STRANDED-DNA;
ASSAY; INTERCALATION; CONSTRUCTION
C1 [Rogers, Kim R.] US EPA, Human Exposure & Atmospher Sci Div, Las Vegas, NV 89119 USA.
[Gary, Ronald K.] Univ Nevada, Dept Chem, Las Vegas, NV 89154 USA.
RP Rogers, KR (reprint author), US EPA, Human Exposure & Atmospher Sci Div, Las Vegas, NV 89119 USA.
NR 55
TC 0
Z9 0
U1 0
U2 4
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, CAMBRIDGE CB4 4WF, CAMBS, ENGLAND
BN 978-1-84973-269-7
PY 2011
BP 99
EP 120
D2 10.1039/9781849732697
PG 22
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Chemistry, Analytical; Engineering, Environmental
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Chemistry; Engineering
GA BWC64
UT WOS:000293462900007
ER
PT B
AU Petri, BG
Watts, RJ
Teel, AL
Huling, SG
Brown, RA
AF Petri, Benjamin G.
Watts, Richard J.
Teel, Amy L.
Huling, Scott G.
Brown, Richard A.
BE Siegrist, RL
Crimi, M
Simpkin, TJ
TI FUNDAMENTALS OF ISCO USING HYDROGEN PEROXIDE
SO IN SITU CHEMICAL OXIDATION FOR GROUNDWATER REMEDIATION
SE SERDP ESTCP Remediation Technology
LA English
DT Article; Book Chapter
C1 [Petri, Benjamin G.] Colorado Sch Mines, Golden, CO 80401 USA.
[Watts, Richard J.; Teel, Amy L.] Washington State Univ, Pullman, WA 99164 USA.
[Huling, Scott G.] US EPA, Robert S Kerr Environm Res Ctr, Ada, OK 74820 USA.
[Brown, Richard A.] Environm Resources Management, Technol Dev, Ewing, NJ 08618 USA.
RP Petri, BG (reprint author), Colorado Sch Mines, Golden, CO 80401 USA.
NR 0
TC 16
Z9 16
U1 2
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-7825-7
J9 SERDP ESTCP REMEDIAT
PY 2011
BP 33
EP 88
DI 10.1007/978-1-4419-7826-4_2
D2 10.1007/978-1-4419-7826-4
PG 56
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA BUN93
UT WOS:000289869300002
ER
PT B
AU Clayton, WS
Petri, BG
Huling, SG
AF Clayton, Wilson S.
Petri, Benjamin G.
Huling, Scott G.
BE Siegrist, RL
Crimi, M
Simpkin, TJ
TI FUNDAMENTALS OF ISCO USING OZONE
SO IN SITU CHEMICAL OXIDATION FOR GROUNDWATER REMEDIATION
SE SERDP ESTCP Remediation Technology
LA English
DT Article; Book Chapter
C1 [Clayton, Wilson S.] Aquifer Solut Inc, Evergreen, CO 80439 USA.
[Petri, Benjamin G.] Colorado Sch Mines, Golden, CO 80401 USA.
[Huling, Scott G.] US EPA, Robert S Kerr Environm Res Ctr, Ada, OK 74820 USA.
RP Clayton, WS (reprint author), Aquifer Solut Inc, Evergreen, CO 80439 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-7825-7
J9 SERDP ESTCP REMEDIAT
PY 2011
BP 193
EP 232
DI 10.1007/978-1-4419-7826-4_5
D2 10.1007/978-1-4419-7826-4
PG 40
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA BUN93
UT WOS:000289869300005
ER
PT B
AU Munakata-Marr, J
Sorenson, KS
Petri, BG
Cummings, JB
AF Munakata-Marr, Junko
Sorenson, Kent S., Jr.
Petri, Benjamin G.
Cummings, James B.
BE Siegrist, RL
Crimi, M
Simpkin, TJ
TI PRINCIPLES OF COMBINING ISCO WITH OTHER IN SITU REMEDIAL APPROACHES
SO IN SITU CHEMICAL OXIDATION FOR GROUNDWATER REMEDIATION
SE SERDP ESTCP Remediation Technology
LA English
DT Article; Book Chapter
ID POLYCYCLIC AROMATIC-HYDROCARBONS; ACTIVATED PERSULFATE OXIDATION; OIL
CONTAMINATED SOIL; TERT-BUTYL ETHER; FENTONS REAGENT; INDIGENOUS
MICROORGANISMS; BIOLOGICAL TREATMENT; HYDROGEN-PEROXIDE; REDUCTIVE
DECHLORINATION; POTASSIUM-PERMANGANATE
C1 [Munakata-Marr, Junko] Colorado Sch Mines, Environm Sci & Engn Div, Golden, CO 80401 USA.
[Sorenson, Kent S., Jr.] CDM, Denver, CO 80202 USA.
[Cummings, James B.] US EPA, Off Solid Waste Emergency Response, Washington, DC 20460 USA.
RP Munakata-Marr, J (reprint author), Colorado Sch Mines, Environm Sci & Engn Div, Golden, CO 80401 USA.
NR 105
TC 2
Z9 2
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4419-7825-7
J9 SERDP ESTCP REMEDIAT
PY 2011
BP 285
EP 317
DI 10.1007/978-1-4419-7826-4_7
D2 10.1007/978-1-4419-7826-4
PG 33
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA BUN93
UT WOS:000289869300007
ER
PT J
AU Rowe, MD
Fairall, CW
Perlinger, JA
AF Rowe, M. D.
Fairall, C. W.
Perlinger, J. A.
TI Chemical sensor resolution requirements for near-surface measurements of
turbulent fluxes
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID GASEOUS DRY DEPOSITION; ORGANIC-COMPOUNDS; MASS-SPECTROMETRY; WATER
EXCHANGE; CARBON-DIOXIDE; FOREST; PARAMETERIZATION; GAS; DISJUNCT;
MERCURY
AB Businger and Delany (1990) presented an approach to estimate the sensor resolution required to limit the contribution of the uncertainty in the chemical concentration measurement to uncertainty in the flux measurement to 10% for eddy covariance, gradient, and relaxed eddy accumulation flux measurement methods. We describe an improvement to their approach to estimate required sensor resolution for the covariance method, and include disjunct eddy covariance. In addition, we provide data to support selection of a form for the dimensionless scalar standard deviation similarity function based on observations of the variance of water vapor fluctuations from recent field experiments. We also redefine the atmospheric parameter of Businger and Delany in a more convenient, dimensionless form. We introduce a "chemical parameter" based on transfer velocity parameterizations. Finally, we provide examples in which the approach is applied to measurement of carbon dioxide, dimethylsulfide, and hexachlorobenzene fluxes over water. The information provided here will be useful to plan field measurements of atmosphere-surface exchange fluxes of trace gases.
C1 [Rowe, M. D.; Perlinger, J. A.] Michigan Technol Univ, Houghton, MI 49931 USA.
[Fairall, C. W.] NOAA, ESRL, Boulder, CO 80305 USA.
RP Rowe, MD (reprint author), US EPA, 9311 Groh Rd, Grosse Ile, MI 48138 USA.
EM rowe.mark@epa.gov
OI Rowe, Mark/0000-0002-0852-3346
FU NOAA; NOAA Climate Observations Division
FX C. Fairall's contributions are supported by the NOAA Health of the
Atmosphere Program and the NOAA Climate Observations Division.
NR 48
TC 13
Z9 13
U1 0
U2 18
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2011
VL 11
IS 11
BP 5263
EP 5275
DI 10.5194/acp-11-5263-2011
PG 13
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 777PT
UT WOS:000291636400010
ER
PT S
AU Wikoff, DS
Birnbaum, L
AF Wikoff, Daniele Staskal
Birnbaum, Linda
BE Eljarrat, E
Barcelo, D
TI Human Health Effects of Brominated Flame Retardants
SO BROMINATED FLAME RETARDANTS
SE Handbook of Environmental Chemistry Series
LA English
DT Article; Book Chapter
DE Endocrine disruption; Hexabromocyclododecane; Polybrominated diphenyl
ether; Tetrabromobisphenol A; Thyroid hormones
ID POLYBROMINATED DIPHENYL ETHERS; THYROID-HORMONE RECEPTOR; ADRENOCORTICAL
CARCINOMA-CELLS; SALMONELLA MUTAGENICITY TESTS; HUMAN NEUTROPHIL
GRANULOCYTES; ONE-GENERATION REPRODUCTION; FREE-RADICAL FORMATION;
TETRABROMOBISPHENOL-A; IN-VITRO; HEXABROMOCYCLODODECANE HBCD
AB In this chapter, we review human health effects associated with the brominated flame retardants (BFRs) that have constituted the overwhelming majority of BFR production and subsequent exposure in humans. These include tetrabromobisphenol A (TBBPA), hexabromocyclododecane (HBCD), and three commercial mixtures of polybrominated diphenyl ethers (PBDEs), or biphenyl oxides, which are known as decabromodiphenyl ether (DecaBDE), octabromodiphenyl ether (OctaBDE), and pentabromodiphenyl ether (PentaBDE). The primary endpoint of concern appears to be endocrine disruption. Other potential effects include hepatotoxicity and neurotoxicity, the later particularly during development. While the toxicological database for these chemicals is growing, further research is needed to understand potential health effects associated with less-studied PBDE congeners, examine the potential carcinogenicity of HBCD and TBBPA, and investigate the overall toxicity of a number of developing alternative BFRs. The increasing contamination of the environment and people by BFRs coupled with clear evidence of adverse health effects resulting from their exposure highlights the importance of identifying emerging issues and data gaps to fully understand the human health risks.
C1 [Wikoff, Daniele Staskal] ToxStrategies, Austin, TX 78731 USA.
[Birnbaum, Linda] Natl Inst Environm Hlth Sci, Durham, NC USA.
RP Wikoff, DS (reprint author), ToxStrategies, 3420 Execut Ctr Dr,Suite 114, Austin, TX 78731 USA.
EM dstaskal@toxstrategies.com
NR 130
TC 8
Z9 8
U1 2
U2 22
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 1433-6863
BN 978-3-642-19268-5
J9 HANDB ENVIRON CHEM
JI Handb. Environ. Chem.
PY 2011
VL 16
BP 19
EP 53
DI 10.1007/698_2010_97
D2 10.1007/978-3-642-19269-2
PG 35
WC Chemistry, Applied; Chemistry, Analytical; Environmental Sciences
SC Chemistry; Environmental Sciences & Ecology
GA BVE65
UT WOS:000291322400002
ER
PT B
AU Posthuma, L
Suter, GW
AF Posthuma, Leo
Suter, Glenn W.
BE Swartjes, FA
TI Ecological Risk Assessment of Diffuse and Local Soil Contamination Using
Species Sensitivity Distributions
SO DEALING WITH CONTAMINATED SITES: FROM THEORY TOWARDS PRACTICAL
APPLICATION
LA English
DT Article; Book Chapter
ID CONCENTRATION ADDITION; INDEPENDENT ACTION; QUALITY CRITERIA; TOXIC
PRESSURE; HEAVY-METALS; CHEMICALS; MIXTURES; ECOSYSTEMS; STANDARDS;
POLLUTION
AB Ecological Risk Assessment related to soil contamination requires a conceptual framework and practical tools to support Risk Management. The conceptual framework is provided by the Risk Assessment paradigm, which means that risks are assessed based on an Exposure Assessment and an Effect Assessment step. Current practical tools to appraise soil quality by Ecological Risk Assessment are: (1) comparison of soil contaminant concentrations to ecological Soil Quality Standards; (2) quantification of ecological risks by modeling; (3) quantification of impacts in bioassays or in field monitoring; and (4) quantification of ecological risks by weight-of-evidence approaches. The present chapter concerns the theory and practices of Effect Assessment and risk modeling using Species Sensitivity Distributions (SSDs), and similar Functional Sensitivity Distributions (FSDs). SSD- and FSD-based Risk Assessment outputs are used for the appraisal of soil quality, soil protection and the management of (slightly and highly) contaminated sites, for both the upper soil and the groundwater. For the appraisal of soil and soil protection, one can derive Hazardous Concentrations (HCs) for individual contaminants, which are estimates of the concentration of a chemical that would affect a defined fraction of species. Likewise, one can derive Hazard Potentials (HPs) for contaminated soil samples, which represent effects levels for a certain fraction of the tested soil species when exposed in such a soil. This chapter introduces the theory of SSDs and illustrates the types of practical applications of SSD-based effect and risk models in all four of the aforementioned types of tools. Since Risk Assessment requires assessments of exposure as well as effects, the chapter also discusses Exposure Assessments for SSDs. Practical software models and database tools are described, to support easy application of SSDs in practice. Through the examples, the reader is informed on a multitude of useful options for SSD-based assessment. SSD-modeling is versatile, and can be of use to a range of soil contamination problems, from diffuse contamination in large areas to local contamination hot spots.
C1 [Posthuma, Leo] Natl Inst Publ Hlth & Environm RIVM, Dept Soil, Bilthoven, Netherlands.
[Suter, Glenn W.] US EPA, Natl Ctr Environm Assessment, Cincinnati, OH USA.
RP Posthuma, L (reprint author), Natl Inst Publ Hlth & Environm RIVM, Dept Soil, Bilthoven, Netherlands.
EM leo.posthuma@rivm.nl; suter.glenn@epa.gov
NR 90
TC 9
Z9 9
U1 2
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-90-481-9756-9
PY 2011
BP 625
EP 691
DI 10.1007/978-90-481-9757-6_14
D2 10.1007/978-90-481-9757-6
PG 67
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA BTG62
UT WOS:000286907000014
ER
PT S
AU Burgess, RM
Ho, KT
Biales, AD
Brack, W
AF Burgess, Robert M.
Ho, Kay T.
Biales, Adam D.
Brack, Werner
BE Brack, W
TI Recent Developments in Whole Sediment Toxicity Identification
Evaluations: Innovations in Manipulations and Endpoints
SO EFFECT-DIRECTED ANALYSIS OF COMPLEX ENVIRONMENTAL CONTAMINATION
SE Handbook of Environmental Chemistry Series
LA English
DT Article; Book Chapter
DE Bioavailability; Genomics; Pesticides; Supercritical fluid extraction;
Toxicity identification evaluation; Whole sediment
ID SUPERCRITICAL-FLUID EXTRACTION; CARBON-DIOXIDE EXTRACTION; PYRETHROID
INSECTICIDES; GENE-EXPRESSION; PIPERONYL BUTOXIDE; EVALUATION TOOLS;
ORGANOPHOSPHATE INSECTICIDES; NATURAL-POPULATIONS; WATER DESORPTION;
HYALELLA-AZTECA
AB Whole sediment toxicity identification evaluation (TIE) methods were developed primarily in the late 1990s and early 2000s in research programs dedicated to developing manipulations and endpoints to characterize and identify causes of toxicity to benthic freshwater and marine organisms. The focus of these methods included nonionic organic contaminants, cationic and anionic metals, and ammonia. This chapter discusses innovations in whole sediment TIE manipulations and endpoints developed primarily over the last 10 years. Innovations such as the use of supercritical fluid extraction as a Phase III manipulation, Phase II methods for identifying pyrethroid, organophosphate, and carbamate pesticides, and the integration of genomic endpoints into the TIE structure are described. In North America, recently implemented environmental regulations require the diagnosis and identification of environmental stressors as part of the total maximum daily loading process. These regulations are likely to result in an increase in the conduct of whole sediments TIEs and encourage the development and application of more innovations.
C1 [Burgess, Robert M.; Ho, Kay T.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA.
[Biales, Adam D.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Ecol Exposure Res Div, Cincinnati, OH 45268 USA.
[Brack, Werner] UFZ Helmholtz Ctr Environm Res, Dept Effects Directed Anal, D-04318 Leipzig, Germany.
RP Burgess, RM (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA.
EM burgess.robert@epa.gov
NR 80
TC 5
Z9 5
U1 0
U2 0
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 1433-6863
BN 978-3-642-18383-6
J9 HANDB ENVIRON CHEM
JI Handb. Environ. Chem.
PY 2011
VL 15
BP 19
EP 40
DI 10.1007/978-3-642-18384-3_2
D2 10.1007/978-3-642-18384-3
PG 22
WC Chemistry, Analytical; Environmental Sciences
SC Chemistry; Environmental Sciences & Ecology
GA BVE66
UT WOS:000291322800002
ER
PT B
AU Sen, KY
AF Sen, Keya
BE Sen, K
Ashbolt, NJ
TI The Needle in a Haystack: Detection of Microbes in Source and Drinking
Water by Molecular Methods
SO ENVIRONMENTAL MICROBIOLOGY: CURRENT TECHNOLOGY AND WATER APPLICATIONS
LA English
DT Article; Book Chapter
ID REAL-TIME PCR; SEQUENCE-BASED AMPLIFICATION; ESCHERICHIA-COLI O157-H7;
REVERSE-TRANSCRIPTION-PCR; ASSISTED-LASER-DESORPTION/IONIZATION;
IONIZATION-MASS-SPECTROMETRY; HEPATITIS-A VIRUS; TRANSFORM
INFRARED-SPECTROSCOPY; CRYPTOSPORIDIUM-PARVUM OOCYSTS; NUCLEIC-ACID
AMPLIFICATION
AB Molecular techniques based on genomics, proteomics and transcriptomics are rapidly growing as complete microbial genome sequences are becoming available, and advances are made in sequencing technology, analytical biochemistry, microfluidics and data analysis. While the clinical and food industries are increasingly adapting these techniques, there appear to be major challenges in detecting health-related microbes in source and treated drinking waters. This is due in part to the low density of pathogens in water, necessitating the processing of significantly large volume samples. In this chapter, the state-of-the-art techniques available for pathogen detection and characterization from water are discussed. From the vast panorama of available techniques, only those that are finding a place in the water industry are presented. Quantitative PCR is the prime focus of this chapter, along with protein detection and immunological approaches, with other molecular techniques such as loop-mediated isothermal amplification (LAMP) and microarrays being the focus of other chapters. A detailed section on future trends is also included.
C1 US EPA, Amer Soc Microbiol, Off Water, Cincinnati, OH USA.
RP Sen, KY (reprint author), US EPA, Amer Soc Microbiol, Off Water, Cincinnati, OH USA.
EM sen.keya@epa.gov
NR 142
TC 1
Z9 1
U1 1
U2 9
PU CAISTER ACADEMIC PRESS
PI WYMONDHAM
PA 32 HEWITTS LANE, WYMONDHAM NR 18 0JA, ENGLAND
BN 978-1-904455-70-7
PY 2011
BP 1
EP 38
PG 38
WC Marine & Freshwater Biology; Microbiology
SC Marine & Freshwater Biology; Microbiology
GA BRX03
UT WOS:000283818300001
ER
PT B
AU Lindquist, HDA
AF Lindquist, H. D. Alan
BE Sen, K
Ashbolt, NJ
TI Taking the Hay Out of the Haystack: Collecting and Processing Water
Samples
SO ENVIRONMENTAL MICROBIOLOGY: CURRENT TECHNOLOGY AND WATER APPLICATIONS
LA English
DT Article; Book Chapter
ID REAL-TIME PCR; CRYPTOSPORIDIUM-PARVUM OOCYSTS; SEPARATION CHANNEL
CENTRIFUGATION; HOLLOW-FIBER ULTRAFILTRATION; COATED PARAMAGNETIC BEADS;
FLIGHT MASS-SPECTROMETRY; GIARDIA-LAMBLIA CYSTS; HUMAN ENTERIC VIRUSES;
DRINKING-WATER; IMMUNOMAGNETIC SEPARATION
AB Methods for the detection of microorganisms in drinking or source water invariably involve the collection of a water sample and some treatment to reduce the volume of that sample. Numerous methods have been developed for water sample collection and subsequent treatment of this collected sample, including filtration, sedimentation, and attraction of the microorganisms of interest to various molecules or substrates. Once the sample volume has been reduced, it is imperative to remove some of the non-target elements of the sample, as these substances generally interfere with the detection of microorganisms. Application of many molecular technologies for sample treatment involves a further step of extraction of genetic material from the microorganisms. Although mechanisms and techniques have been devised for each part of the sample collection and treatment process, there is considerable room for improvement.
C1 US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Water Infrastruct Protect Div, Cincinnati, OH 45268 USA.
RP Lindquist, HDA (reprint author), US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Water Infrastruct Protect Div, Cincinnati, OH 45268 USA.
EM lindquist.alan@epa.gov
NR 101
TC 2
Z9 2
U1 0
U2 5
PU CAISTER ACADEMIC PRESS
PI WYMONDHAM
PA 32 HEWITTS LANE, WYMONDHAM NR 18 0JA, ENGLAND
BN 978-1-904455-70-7
PY 2011
BP 39
EP 64
PG 26
WC Marine & Freshwater Biology; Microbiology
SC Marine & Freshwater Biology; Microbiology
GA BRX03
UT WOS:000283818300002
ER
PT B
AU Shanks, OC
McLellan, S
Huse, SM
Sogin, ML
AF Shanks, Orin C.
McLellan, Sandra
Huse, Susan M.
Sogin, Mitchell L.
BE Sen, K
Ashbolt, NJ
TI Characterization of Microbial Community Structures in Recreational
Waters and Primary Sources of Faecal Pollution with a Next-generation
Sequencing Approach
SO ENVIRONMENTAL MICROBIOLOGY: CURRENT TECHNOLOGY AND WATER APPLICATIONS
LA English
DT Article; Book Chapter
ID 16S RIBOSOMAL-RNA; REAL-TIME PCR; REVERSE-TRANSCRIPTASE PCR; HUMAN GUT
MICROBIOTA; ESCHERICHIA-COLI; GENETIC-MARKERS; SOURCE TRACKING; SOURCE
IDENTIFICATION; NONPOINT SOURCES; NEARSHORE WATER
AB The invention of new approaches to DNA sequencing commonly referred to as next generation sequencing technologies is revolutionizing the study of microbial diversity. In this chapter, we discuss the characterization of microbial population structures in surface waters and potentially contributing faecal sources using a GS-FLX pyrosequencer. An overview of the principals of the technology, workflow, sequencing strategies, and data analysis challenges are included. In addition, the bacterial population structure of an untreated wastewater sewage sample is reported and discussed to demonstrate a pyrosequencing approach for studying a microbial community. Emphasis is placed on the application of pyrosequencing technology for recreational water quality management including the discovery of alternative indicators of faecal pollution and improving the link between faecal pollution and the transmission of waterborne disease.
C1 [Shanks, Orin C.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
[McLellan, Sandra] Great Lakes WATER Inst, Milwaukee, WI USA.
[Huse, Susan M.; Sogin, Mitchell L.] Marine Biol Lab, Josephine Bay Paul Ctr, Woods Hole, MA 02543 USA.
RP Shanks, OC (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
EM shanks.orin@epa.gov; mclellan@uwm.edu; shuse@mbl.edu; sogine@mbl.edu
NR 104
TC 1
Z9 1
U1 2
U2 9
PU CAISTER ACADEMIC PRESS
PI WYMONDHAM
PA 32 HEWITTS LANE, WYMONDHAM NR 18 0JA, ENGLAND
BN 978-1-904455-70-7
PY 2011
BP 203
EP 223
PG 21
WC Marine & Freshwater Biology; Microbiology
SC Marine & Freshwater Biology; Microbiology
GA BRX03
UT WOS:000283818300009
ER
PT B
AU Domingo, JWS
Lamendella, R
Ashbolt, NJ
AF Domingo, Jorge W. Santo
Lamendella, Regina
Ashbolt, Nicholas J.
BE Sen, K
Ashbolt, NJ
TI Microbial Source Tracking: Current and Future Molecular Tools in
Microbial Water Quality Forensics
SO ENVIRONMENTAL MICROBIOLOGY: CURRENT TECHNOLOGY AND WATER APPLICATIONS
LA English
DT Article; Book Chapter
ID HUMAN FECAL POLLUTION; 16S RIBOSOMAL-RNA; REAL-TIME PCR; BACTERIAL
SOURCE TRACKING; MITOCHONDRIAL GENOME ARRANGEMENTS; ENTEROTOXIGENIC
ESCHERICHIA-COLI; ANTIBIOTIC-RESISTANCE ANALYSIS; RIBONUCLEIC-ACID
COLIPHAGES; LIBRARY-INDEPENDENT MARKERS; SWINE PRODUCTION FACILITIES
AB Regulations in the United States and elsewhere stipulate that drinking and recreational waters should be regularly monitored for microbial indicators of faecal pollution. Hence, the health risks associated with these waters are determined using microbial surrogates rather than by direct pathogen detection. Detecting pathogens may seem more appropriate, however, pathogens are difficult to enumerate since they are often present in environmental samples in very low numbers that still present health concerns and may take several days to weeks to detect, lessening their value for risk management. In this chapter, we discuss the use of molecular methods that attempt to track faecal sources of pollution in environmental waters and discuss their role in environmental monitoring and management. A general description of the most commonly used methods is provided, and where appropriate, some of the advantages and limitations are highlighted. The use of genomic technologies to develop new methods and to fill existing research gaps in microbial source tracking (MST) is also discussed. As clear from other chapters of this book, the field of environmental microbiology is undergoing a fundamental change through the development of tools that can describe the molecular diversity of microbial populations relevant to environmental faecal pollution. While this is a dynamic field, emphasis is placed on culture-independent methods relying on DNA-based targets that currently dominate the scientific literature.
C1 [Domingo, Jorge W. Santo] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Water Supply & Water Resources Div,Microbial Cont, Cincinnati, OH 45268 USA.
[Lamendella, Regina] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Earth Sci, Berkeley, CA 94720 USA.
[Ashbolt, Nicholas J.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Microbiol & Chem Exposure Assessment Res Div, Cincinnati, OH 45268 USA.
RP Domingo, JWS (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Water Supply & Water Resources Div,Microbial Cont, Cincinnati, OH 45268 USA.
EM santodomingo.jorge@epa.gov; rlamendella@lbl.gov; ashbolt.nick@epa.gov;
ashbolt.nick@epa.gov
NR 173
TC 0
Z9 0
U1 2
U2 13
PU CAISTER ACADEMIC PRESS
PI WYMONDHAM
PA 32 HEWITTS LANE, WYMONDHAM NR 18 0JA, ENGLAND
BN 978-1-904455-70-7
PY 2011
BP 225
EP 250
PG 26
WC Marine & Freshwater Biology; Microbiology
SC Marine & Freshwater Biology; Microbiology
GA BRX03
UT WOS:000283818300010
ER
PT S
AU Fox, TR
Miller, BW
Rubilar, R
Stape, JL
Albaugh, TJ
AF Fox, Thomas R.
Miller, Bradley W.
Rubilar, Rafael
Stape, Jose L.
Albaugh, Timothy J.
BE Bunemann, EK
Oberson, A
Frossard, E
TI Phosphorus Nutrition of Forest Plantations: The Role of Inorganic and
Organic Phosphorus
SO PHOSPHORUS IN ACTION: BIOLOGICAL PROCESSES IN SOIL PHOSPHORUS CYCLING
SE Soil Biology
LA English
DT Article; Book Chapter
ID NUCLEAR-MAGNETIC-RESONANCE; SOUTHERN PINE PLANTATIONS; ROTATION RADIATA
PINE; LOBLOLLY-PINE; SOIL-PHOSPHORUS; PHOSPHATASE-ACTIVITY;
UNITED-STATES; EUCALYPT PLANTATIONS; ECTOMYCORRHIZAL FUNGI; HEDLEY
FRACTIONATION
C1 [Fox, Thomas R.] Virginia Polytech Inst & State Univ, Dept Forest Resources & Environm Conservat, Blacksburg, VA 24061 USA.
[Miller, Bradley W.] US EPA, Natl Risk Management Res Lab, Land Remediat & Pollut Control Div, Cincinnati, OH 45224 USA.
[Rubilar, Rafael] Univ Concepcion, Fac Ciencias Forestales, Dept Silvicultura, Concepcion, Chile.
[Stape, Jose L.; Albaugh, Timothy J.] N Carolina State Univ, Dept Forestry & Environm Resources, Raleigh, NC 27695 USA.
RP Fox, TR (reprint author), Virginia Polytech Inst & State Univ, Dept Forest Resources & Environm Conservat, 228 Cheatham Hall, Blacksburg, VA 24061 USA.
NR 164
TC 10
Z9 10
U1 2
U2 11
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 1613-3382
BN 978-3-642-15270-2
J9 SOIL BIOL
JI Soil Biol.
PY 2011
VL 26
BP 317
EP 338
DI 10.1007/978-3-642-15271-9_13
D2 10.1007/978-3-642-15271-9
PG 22
WC Soil Science
SC Agriculture
GA BSL41
UT WOS:000284856400013
ER
PT J
AU Sarofim, MC
Reilly, JM
AF Sarofim, Marcus C.
Reilly, John M.
TI Applications of integrated assessment modeling to climate change
SO WILEY INTERDISCIPLINARY REVIEWS-CLIMATE CHANGE
LA English
DT Article
ID GREENHOUSE GASES; POLICY; STABILIZATION; EMISSIONS; MITIGATION;
SCENARIOS; IMPACTS; ADAPTATION; ECONOMICS; IPCC
AB Climate change studies are often interdisciplinary by nature, incorporating many domains of science, economics, and political theory. Integrated assessment (IA) aims to bring diverse scientific, economics and social science expertise together to provide analysis and advice that comprehensively addresses all or at least many aspects of the climate change issue. IA methods have been applied to many areas of climate change providing insights into areas such as optimal timing of emission reductions, weighting of different greenhouse gases, or impacts of biofuel policies. Additionally, IAs have identified key uncertainties that should be priorities of future research, such as the need to understand oceanic heat uptake in order to better constrain climate sensitivity and predict future timing of temperature change. These assessments have also served to establish ongoing communication within the community of researchers, and between researchers and policy makers. In complex scientific issues it is often difficult for policy makers and the public to sort out conflicting scientific views, and an authoritative assessment process can provide consensus views on the issue, accepting that in some cases the "consensus"' may be that some aspects of the issue remain unresolved. This review explores the history and applications of these IAs, and identifies avenues for future emphasis. We briefly review the whole field of IAs of climate change, but focus on the role of formal computational frameworks in IA models. (c) 2010 John Wiley & Sons, Ltd. WIREs Clim Change 2011 2 27-44 DOI: 10.1002/wcc.93
C1 [Reilly, John M.] MIT, Joint Program Sci & Policy Global Change, Cambridge, MA 02139 USA.
[Sarofim, Marcus C.] US EPA, Washington, DC 20460 USA.
RP Reilly, JM (reprint author), MIT, Joint Program Sci & Policy Global Change, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
EM jreilly@mit.edu
NR 70
TC 5
Z9 5
U1 1
U2 14
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1757-7780
EI 1757-7799
J9 WIRES CLIM CHANGE
JI Wiley Interdiscip. Rev.-Clim. Chang.
PD JAN-FEB
PY 2011
VL 2
IS 1
BP 27
EP 44
DI 10.1002/wcc.93
PG 18
WC Environmental Studies; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 778WG
UT WOS:000291739500004
ER
PT J
AU Neumann, J
Hudgens, D
Herter, J
Martinich, J
AF Neumann, James
Hudgens, Daniel
Herter, John
Martinich, Jeremy
TI The economics of adaptation along developed coastlines
SO WILEY INTERDISCIPLINARY REVIEWS-CLIMATE CHANGE
LA English
DT Article
ID SEA-LEVEL RISE; UNITED-STATES; HOLDING BACK; COST
AB Sea-level rise (SLR) increases the risk of permanent inundation of coastal lands and structures, while also increasing the risk of periodic damage from storms and risks to ecological resources. Prior studies have illustrated the importance of considering adaptation measures, such as armoring and beach nourishment, when estimating the economic cost of SLR, but these studies have taken the form either of careful, geographically limited case studies or national estimates based on limited samples. We present a framework for evaluating the economics of adaptation to permanent inundation from SLR that employs detailed local scale data and is spatially comprehensive, and apply the framework to estimate costs of adaptation for the full coastline of the continental US. Our results show that the economic cost of SLR is much larger than prior estimates suggest-more than $63 billion cumulative discounted cost (at 3%) for a 68 cm SLR by 2100, and $230 billion undiscounted-yet is only one-fourth the total value of low-lying property vulnerable to SLR, illustrating the importance of careful site-specific consideration of adaptation. Further, the granularity of the framework provides spatial, temporal, and response mode details useful to both national policy-makers and local adaptation planners, and can readily incorporate estimates of ecological and storm surge damages as they become available. (c) 2010 John Wiley & Sons, Ltd. WIREs Clim Change 2011 2 89-98 DOI: 10.1002/wcc.90
C1 [Neumann, James; Hudgens, Daniel; Herter, John] Ind Econ Inc, Cambridge, MA USA.
[Martinich, Jeremy] US EPA, Climate Sci Impacts Branch, Washington, DC 20460 USA.
RP Neumann, J (reprint author), Ind Econ Inc, Cambridge, MA USA.
EM jneumann@indecon.com
NR 19
TC 11
Z9 11
U1 1
U2 15
PU WILEY PERIODICALS, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN, MA 02148-529 USA
SN 1757-7780
J9 WIRES CLIM CHANGE
JI Wiley Interdiscip. Rev.-Clim. Chang.
PD JAN-FEB
PY 2011
VL 2
IS 1
BP 89
EP 98
DI 10.1002/wcc.90
PG 10
WC Environmental Studies; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 778WG
UT WOS:000291739500007
ER
PT J
AU Hill, BH
Bolgrien, DW
AF Hill, Brian H.
Bolgrien, David W.
TI Nitrogen removal by streams and rivers of the Upper Mississippi River
basin
SO BIOGEOCHEMISTRY
LA English
DT Article
DE Nitrogen removal; River networks; Mississippi River basin
ID GULF-OF-MEXICO; WATER-QUALITY; AQUATIC ECOSYSTEMS; NITRATE REMOVAL;
DENITRIFICATION; SATURATION; RETENTION; DELIVERY; STATES; SIZE
AB We used stream chemistry and hydrogeomorphology data from 549 stream and 447 river sites to estimate NO(3)-N removal in the Upper Mississippi, Missouri, and Ohio Rivers. We used two N removal models to predict NO(3)-N input and removal. NO(3)-N input ranged from 0.01 to 338 kg km(-1) d(-1) in the Upper Mississippi River to < 0.01-54 kg km(-1) d(-1) in the Missouri River. Cumulative river network NO(3)-N input was 98700-101676 Mg year(-1) in the Ohio River, 85961-89288 Mg year(-1) in the Upper Mississippi River, and 59463-61541 Mg year(-1) in the Missouri River. NO(3)-N output was highest in the Upper Mississippi River (0.01-329 kg km(-1) d(-1)), followed by the Ohio and Missouri Rivers (< 0.01-236 kg km(-1) d(-1)) sub-basins. Cumulative river network NO(3)-N output was 97499 Mg year(-1) for the Ohio River, 84361 Mg year(-1) for the Upper Mississippi River, and 59200 Mg year(-1) for the Missouri River. Proportional NO(3)-N removal (PNR) based on the two models ranged from < 0.01 to 0.28. NO(3)-N removal was inversely correlated with stream order, and ranged from < 0.01 to 8.57 kg km(-1) d(-1) in the Upper Mississippi River to < 0.001-1.43 kg km(-1) d(-1) in the Missouri River. Cumulative river network NO(3)-N removal predicted by the two models was: Upper Mississippi River 4152 and 4152 Mg year(-1), Ohio River 3743 and 378 Mg year(-1), and Missouri River 2277 and 197 Mg year(-1). PNR removal was negatively correlated with both stream order (r = -0.80-0.87) and the percent of the catchment in agriculture (r = -0.38-0.76).
C1 [Hill, Brian H.; Bolgrien, David W.] US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Duluth, MN 55804 USA.
RP Hill, BH (reprint author), US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, 6201 Congdon Blvd, Duluth, MN 55804 USA.
EM hill.brian@epa.gov
RI Hill, Brian/E-6799-2013
FU U.S. Environmental Protection Agency
FX We thank Xiaoli Yuan (USGS Upper Midwest Environmental Sciences Center)
for analytical chemistry support for the EMAP samples and the numerous
state analytical laboratories for WSA chemistry; Marlys Cappaert and her
team (CSC, Corp.) for database support; and Tatiana Nawrocki, Matthew
Starry, Roger Meyer, and Jesse Adams (CSC, Corp.) for GIS support. Tony
Olsen supervised the creation of the survey designs. We are especially
indebted to the field crews who collected the data. The information in
this document has been funded wholly by the U.S. Environmental
Protection Agency. It has been subjected to review by the National
Health and Environmental Effects Research Laboratory and approved for
publication. Approval does not signify that the contents reflect the
views of the Agency, nor does mention of trade names or commercial
products constitute endorsement or recommendation for use.
NR 31
TC 6
Z9 7
U1 2
U2 23
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0168-2563
J9 BIOGEOCHEMISTRY
JI Biogeochemistry
PD JAN
PY 2011
VL 102
IS 1-3
BP 183
EP 194
DI 10.1007/s10533-010-9431-8
PG 12
WC Environmental Sciences; Geosciences, Multidisciplinary
SC Environmental Sciences & Ecology; Geology
GA 695GQ
UT WOS:000285359000012
ER
PT J
AU Kriegel, C
Koehne, J
Tinkle, S
Maynard, AD
Hill, RA
AF Kriegel, Christina
Koehne, Jessica
Tinkle, Sally
Maynard, Andrew D.
Hill, Rodney A.
TI Challenges of Trainees in a Multidisciplinary Research Program:
Nano-Biotechnology
SO JOURNAL OF CHEMICAL EDUCATION
LA English
DT Article
C1 [Koehne, Jessica] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA.
[Koehne, Jessica] NASA, Ames Res Ctr, Moffett Field, CA 94035 USA.
[Tinkle, Sally] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC 27709 USA.
[Maynard, Andrew D.] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA.
[Maynard, Andrew D.] Univ Michigan, Sch Publ Hlth, Risk Sci Ctr, Ann Arbor, MI 48109 USA.
[Hill, Rodney A.] Univ Idaho, Dept Anim & Vet Sci, Moscow, ID 83844 USA.
[Kriegel, Christina] Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA.
RP Kriegel, C (reprint author), Northeastern Univ, Dept Pharmaceut Sci, Boston, MA 02115 USA.
EM rodhill@uidaho.edu
OI Maynard, Andrew/0000-0003-2117-5128
NR 12
TC 1
Z9 1
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-9584
J9 J CHEM EDUC
JI J. Chem. Educ.
PD JAN
PY 2011
VL 88
IS 1
BP 53
EP 55
DI 10.1021/ed1001174
PG 3
WC Chemistry, Multidisciplinary; Education, Scientific Disciplines
SC Chemistry; Education & Educational Research
GA 694WE
UT WOS:000285328900014
ER
PT J
AU Mitchell-Blackwood, J
Gurian, PL
O'Donnell, C
AF Mitchell-Blackwood, Jade
Gurian, Patrick L.
O'Donnell, Cara
TI Finding Risk-Based Switchover Points for Response Decisions for
Environmental Exposure to Bacillus anthracis
SO HUMAN AND ECOLOGICAL RISK ASSESSMENT
LA English
DT Article
DE Bacillus anthracis; decision model; risk threshold; cost-benefit
analysis; bioterrorism; response strategies
ID PUBLIC-HEALTH; COST-EFFECTIVENESS; BIOTERRORISM; VACCINATION; ATTACK;
REMEDIATION; PROPHYLAXIS; STRATEGIES; LOGISTICS; MORTALITY
AB In the wake of the 2001 terrorist attacks, the use of Bacillus anthracis (anthrax) in bioterrorism attacks has emerged as a realistic concern. Thus, a contingency plan is needed to inform decision-makers about which response actions are appropriate and justified under which circumstances. This study considers the decisions: (1) to undertake prophylactic antibiotic treatment; (2) to vaccinate individuals; or (3) to decontaminate the building. While these response actions are clearly justified for highly exposed individuals, a very large number of individuals exposed to very small risks in areas outside of the immediate vicinity of the release are also likely. Our results indicate that there are non-negligible risk thresholds below which response actions produce more costs than benefits. For the base case, the thresholds range from a risk of 1 in 33 for decontamination by fumigation to 1 in 6,547 for antibiotic prophylaxis and 1 in 7,108 for vaccination. A one-way sensitivity analysis on uncertain variables indicates less than an order of magnitude change in these thresholds. Benefit-cost analysis is a useful tool for assessing tradeoffs among alternative decisions, but cannot be the sole criterion in responding to incidents because of inherent limitations.
C1 [Mitchell-Blackwood, Jade; Gurian, Patrick L.] Drexel Univ, Dept Civil Architectural & Environm Engn, Philadelphia, PA 19104 USA.
[O'Donnell, Cara] Sci & Technol Policy Inst, Inst Def Anal IDA, Washington, DC USA.
RP Mitchell-Blackwood, J (reprint author), US EPA, 109 T W Alexander Dr,Mail Code E205-02, Res Triangle Pk, NC 27709 USA.
EM mitchell-blackwood.jade@epa.gov
RI Gurian, Patrick/A-8365-2013
OI Gurian, Patrick/0000-0001-7456-9740
FU Center for Advancing Microbial Risk Assessment; U.S. Environmental
Protection Agency; U.S. Department of Homeland Security [R83236201]
FX This research was funded through the Center for Advancing Microbial Risk
Assessment, supported by the U.S. Environmental Protection Agency and
the U.S. Department of Homeland Security, under the Science to Achieve
Results (STAR) grant program (grant number: R83236201).
NR 46
TC 8
Z9 8
U1 0
U2 9
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1080-7039
J9 HUM ECOL RISK ASSESS
JI Hum. Ecol. Risk Assess.
PY 2011
VL 17
IS 2
BP 489
EP 509
AR PII 936278185
DI 10.1080/10807039.2011.552401
PG 21
WC Biodiversity Conservation; Environmental Sciences
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 750SL
UT WOS:000289568200012
ER
PT J
AU Oliver, LM
Lehrter, JC
Fisher, WS
AF Oliver, L. M.
Lehrter, J. C.
Fisher, W. S.
TI Relating landscape development intensity to coral reef condition in the
watersheds of St. Croix, US Virgin Islands
SO MARINE ECOLOGY PROGRESS SERIES
LA English
DT Article
DE Coral reef condition; Coastal watersheds; Land-cover/land-use; Landscape
development intensity (LDI) index
ID CLIMATE-CHANGE; SEDIMENTATION; ECOSYSTEMS; HEALTH; PERSPECTIVE;
GRADIENTS; POLLUTION; RESPONSES; IMPACTS; STRESS
AB Land-based sources of pollution are a major threat to the health of coral reefs. We report, for the first time, a study that relates coral reef condition to human modifications of the landscape. Stony coral community richness, cover, colony size, and density were assessed along with 3-dimensional coral cover in the near-shore waters of St. Croix, US Virgin Islands, in 2006 and 2007. Land use/land cover data (LULC, 2.4 m resolution) and a landscape development intensity (LDI) index, an indicator of human activity calculated from the LULC data, were used to explore relationships with coral indicators. The LDI index was more robust than other indicators of human activity, exhibiting negative correlations with stony coral colony density, taxa richness, colony size, and total coral cover. High variability observed in coral density and taxa richness was better explained when percent natural land and average coral station depth were considered along with the LDI index. Percent impervious surface in the watershed was negatively correlated with 1 coral condition indicator, total coral cover. The LDI index is an effective landscape indicator of human impact on St. Croix corals, highlighting the link between land-based human activity and marine ecosystems. Further development of this tool will aid in land use planning and prioritization of conservation efforts.
C1 [Oliver, L. M.; Lehrter, J. C.; Fisher, W. S.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, Gulf Breeze, FL 32561 USA.
RP Oliver, LM (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA.
EM oliver.leah@epa.gov
NR 47
TC 17
Z9 17
U1 2
U2 31
PU INTER-RESEARCH
PI OLDENDORF LUHE
PA NORDBUNTE 23, D-21385 OLDENDORF LUHE, GERMANY
SN 0171-8630
J9 MAR ECOL PROG SER
JI Mar. Ecol.-Prog. Ser.
PY 2011
VL 427
BP 293
EP 302
DI 10.3354/meps09087
PG 10
WC Ecology; Marine & Freshwater Biology; Oceanography
SC Environmental Sciences & Ecology; Marine & Freshwater Biology;
Oceanography
GA 749SM
UT WOS:000289489800022
ER
PT J
AU Nicolle-Mir, L
AF Nicolle-Mir, Laurence
TI Water contaminants Study on the disinfection by-products of swimming
pool water
SO ENVIRONNEMENT RISQUES & SANTE
LA French
DT News Item
C1 US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Nicolle-Mir, L (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU JOHN LIBBEY EUROTEXT LTD
PI MONTROUGE
PA 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE
SN 1635-0421
J9 ENVIRON RISQUE SANTE
JI Environ. Risque Sante
PD JAN-FEB
PY 2011
VL 10
IS 1
BP 11
EP 12
PG 2
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 735KS
UT WOS:000288413800006
ER
PT J
AU Dzialowski, AR
Smith, VH
Wang, SH
Martin, MC
deNoyelles, F
AF Dzialowski, Andrew R.
Smith, Val H.
Wang, Shih-Hsien
Martin, Michael C.
deNoyelles, F., Jr.
TI Effects of non-algal turbidity on cyanobacterial biomass in seven turbid
Kansas reservoirs
SO LAKE AND RESERVOIR MANAGEMENT
LA English
DT Article
DE cyanobacteria; reservoirs; non-algal turbidity; chlorophyll-a
ID BLUE-GREEN-ALGAE; MISSOURI RESERVOIRS; TOTAL PHOSPHORUS; AQUATIC
SYSTEMS; OXBOW LAKES; DOMINANCE; PHYTOPLANKTON; NUTRIENTS; MICROCYSTIS;
NITROGEN
AB One of the most visible consequences of eutrophication in freshwater lakes is an increase in the biomass of cyanobacteria. While growth of cyanobacteria has been shown to be coupled to water column concentrations of total phosphorus (TP) in natural lakes, the ecological behavior of cyanobacteria in turbid impoundments is less well understood. Patterns of cyanobacterial biovolume in 7 turbid Kansas (USA) reservoirs exhibited overlap with published data from natural lakes in North America. Non-algal turbidity (NAT) influenced the relationship between cyanobacteria and TP in these systems. Relative to yields predicted from natural lakes, the biomass of cyanobacteria per unit TP was typically higher in the reservoirs, except in those systems that had exceptionally high levels of NAT (2.0 2/m) where observed concentrations were mostly lower than predicted. A more consistent pattern was observed with respect to the effects of NAT on yields of chlorophyll-a per unit TP in the reservoirs: across almost the entire NAT gradient, observed chlorophyll-a concentrations were typically lower than those predicted from natural lakes. Taken together, our results confirm that NAT plays an important role in regulating relationships between TP and phytoplankton biomass in reservoir ecosystems.
C1 [Dzialowski, Andrew R.] Oklahoma State Univ, Dept Zool, Stillwater, OK 74078 USA.
[Smith, Val H.] Univ Kansas, Dept Ecol & Evolutionary Biol, Lawrence, KS 66047 USA.
[Wang, Shih-Hsien] US EPA, Water Qual Management Branch, Water Wetlands & Pesticides Div, Kansas City, KS 66101 USA.
[Martin, Michael C.; deNoyelles, F., Jr.] Univ Kansas, Kansas Biol Survey, Lawrence, KS 66047 USA.
RP Dzialowski, AR (reprint author), Oklahoma State Univ, Dept Zool, 501 Life Sci W, Stillwater, OK 74078 USA.
EM andy.dzialowski@okstate.edu
NR 61
TC 9
Z9 10
U1 4
U2 22
PU NORTH AMER LAKE MANAGEMENT SOC
PI MADISON
PA PO BOX 5443, MADISON, WI 53705-5443 USA
SN 1040-2381
J9 LAKE RESERV MANAGE
JI Lake Reserv. Manag.
PY 2011
VL 27
IS 1
BP 6
EP 14
AR PII 934984675
DI 10.1080/07438141.2011.551027
PG 9
WC Limnology; Marine & Freshwater Biology; Water Resources
SC Marine & Freshwater Biology; Water Resources
GA 738XR
UT WOS:000288676400002
ER
PT J
AU Moore, CC
Holmes, TP
Bell, KP
AF Moore, Christopher C.
Holmes, Thomas P.
Bell, Kathleen P.
TI An attribute-based approach to contingent valuation of forest protection
programs
SO JOURNAL OF FOREST ECONOMICS
LA English
DT Article
DE Contingent valuation; Forest conservation; Invasive species; Ecological
services; Non-use value
ID PREFERENCE HETEROGENEITY; EASTERN HEMLOCK; VALUES; QUESTIONS; BENEFITS;
GOODS
AB The hemlock woolly adelgid is an invasive insect that is damaging hemlock forests in the eastern United States. Several control methods are available but forest managers are constrained by cost, availability, and environmental concerns. As a result forest managers must decide how to allocate limited conservation resources over heterogeneous landscapes. We develop an attribute-based contingent valuation approach that allows us to perform cost-benefit analysis on control programs and inform the distribution of mitigation effort over land units that provide different types of environmental services. We use this approach to examine conservation efforts on three land management units in the southern Appalachian Mountains: Great Smoky Mountains National Park and Pisgah and Nantahala National Forests. Managers of these forests are focusing their efforts on specific conservation areas chosen for their importance to human-use or ecological services. The result is a network of sites that implicitly defines a tradeoff between ecological and human-use services. Our survey is designed to examine the public's perception of this tradeoff and estimate WTP for hemlock conservation programs. The estimated benefits of conserving hemlocks in the study area outweigh the cost of the mitigation programs by two orders of magnitude. We find that there is substantial support for protection of hemlock stands providing ecological services with very little human-use value. Further, we show that benefits from the current mitigation strategy could be increased by shifting effort to protect more ecological services at the expense of sites that generate primarily human-use value. Published by Elsevier GmbH on behalf of Department of Forest Economics, SLU Umea Sweden.
C1 [Moore, Christopher C.] US EPA, Natl Ctr Environm Econ, Washington, DC 20460 USA.
[Bell, Kathleen P.] Univ Maine, Sch Econ, Orono, ME USA.
RP Moore, CC (reprint author), US EPA, Natl Ctr Environm Econ, 1200 Penn Ave NW,MC 1809T, Washington, DC 20460 USA.
EM moore.chris@epa.gov
FU Center for Environmental and Resource Policy; USDA
FX The authors would like to thank two anonymous reviewers, the Center for
Environmental and Resource Policy and the USDA National Needs Fellowship
for funding this research and Dan Phaneuf for substantial assistance in
designing the survey. As always, any remaining errors are that of the
authors alone.
NR 55
TC 13
Z9 13
U1 10
U2 24
PU ELSEVIER GMBH, URBAN & FISCHER VERLAG
PI JENA
PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY
SN 1104-6899
J9 J FOREST ECON
JI J. For. Econ.
PY 2011
VL 17
IS 1
BP 35
EP 52
DI 10.1016/j.jfe.2010.09.001
PG 18
WC Economics; Forestry
SC Business & Economics; Forestry
GA 733AD
UT WOS:000288231900004
ER
PT J
AU Henderson, BH
Pinder, RW
Crooks, J
Cohen, RC
Hutzell, WT
Sarwar, G
Goliff, WS
Stockwell, WR
Fahr, A
Mathur, R
Carlton, AG
Vizuete, W
AF Henderson, B. H.
Pinder, R. W.
Crooks, J.
Cohen, R. C.
Hutzell, W. T.
Sarwar, G.
Goliff, W. S.
Stockwell, W. R.
Fahr, A.
Mathur, R.
Carlton, A. G.
Vizuete, W.
TI Evaluation of simulated photochemical partitioning of oxidized nitrogen
in the upper troposphere
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID HO2NO2 PEROXYNITRIC ACID; GAS-PHASE REACTIONS; ATMOSPHERIC CHEMISTRY;
HOX; MODELS; OZONE; NOX; MECHANISMS; O-3
AB Regional and global chemical transport models underpredict NOx (NO + NO2) in the upper troposphere where it is a precursor to the greenhouse gas ozone. The NOx bias has been shown in model evaluations using aircraft data (Singh et al., 2007) and total column NO2 (molecules cm(-2)) from satellite observations (Napelenok et al., 2008). The causes of NOx underpredictions have yet to be fully understood due to the interconnected nature of simulated emission, transport, and chemistry processes. Recent observation-based studies, in the upper troposphere, identify chemical rate coefficients as a potential source of error (Olson et al., 2006; Ren et al., 2008). Since typical chemistry evaluation techniques are not available for upper tropospheric conditions, this study develops an evaluation platform from in situ observations, stochastic convection, and deterministic chemistry. We derive a stochastic convection model and optimize it using two simulated datasets of time since convection, one based on meteorology, and the other on chemistry. The chemistry surrogate for time since convection is calculated using seven different chemical mechanisms, all of which predict shorter time since convection than our meteorological analysis. We evaluate chemical simulations by inter-comparison and by pairing results with observations based on NOx:HNO3, a photochemical aging indicator. Inter-comparison reveals individual chemical mechanism biases and recommended updates. Evaluation against observations shows that all chemical mechanisms overpredict NOx removal relative to long-lived methanol and carbon monoxide. All chemical mechanisms underpredict observed NOx by at least 30%, and further evaluation is necessary to refine simulation sensitivities to initial conditions and chemical rate uncertainties.
C1 [Henderson, B. H.; Vizuete, W.] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27515 USA.
[Henderson, B. H.; Pinder, R. W.; Crooks, J.; Hutzell, W. T.; Sarwar, G.; Mathur, R.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC USA.
[Cohen, R. C.] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA.
[Cohen, R. C.] Univ Calif Berkeley, Dept Earth & Planetary Sci, Berkeley, CA 94720 USA.
[Goliff, W. S.] Univ Calif Riverside, Coll Engn CERT, Riverside, CA 92521 USA.
[Stockwell, W. R.; Fahr, A.] Howard Univ, Dept Chem, Washington, DC 20059 USA.
[Carlton, A. G.] Rutgers State Univ, Dept Environm Sci, New Brunswick, NJ 08903 USA.
RP Henderson, BH (reprint author), Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27515 USA.
EM barronh@gmail.com
RI Carlton, Annmarie/A-7867-2011; Pinder, Robert/F-8252-2011; Cohen,
Ronald/A-8842-2011; Henderson, Barron/E-4392-2014;
OI Carlton, Annmarie/0000-0002-8574-1507; Pinder,
Robert/0000-0001-6390-7126; vizuete, william/0000-0002-1399-2948; Cohen,
Ronald/0000-0001-6617-7691; Henderson, Barron/0000-0002-6755-3051;
Stockwell, William/0000-0002-7509-6575
FU National Exposure Research Laboratory, US Environmental Protection
Agency through the US Department of Energy and EPA; NOAA; Minority
Serving Institutions (EPP/MSI) through the NOAA Center for Atmospheric
Sciences (NCAS) [NA06OAR4810172]; National Science Foundation [0653997];
Howard University [NNX08AQ68G]
FX This research was supported in part by an appointment to the Research
Participation Program at the National Exposure Research Laboratory, US
Environmental Protection Agency administered by the Oak Ridge Institute
for Science and Education through an inter-agency agreement between the
US Department of Energy and EPA.; In addition to the EPA program William
R. Stockwell was supported in part by the NOAA Educational Partnership
Program with Minority Serving Institutions (EPP/MSI) under grant number
of NA06OAR4810172 through the NOAA Center for Atmospheric Sciences
(NCAS) and National Science Foundation grant award number: 0653997.;
Askar Fahr thanks NASA-Outer Planets Research Program for partial
support of this work under Contract #NNX08AQ68G at Howard University.
NR 45
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Z9 19
U1 1
U2 20
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2011
VL 11
IS 1
BP 275
EP 291
DI 10.5194/acp-11-275-2011
PG 17
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 705ZO
UT WOS:000286180200020
ER
PT J
AU Geron, C
AF Geron, Chris
TI Carbonaceous aerosol characteristics over a Pinus taeda plantation:
Results from the CELTIC experiment
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE CELTIC elemental carbon; Organic carbon; Radiocarbon; PM(2.5); Ozone;
Biogenic volatile organic compounds
ID SECONDARY ORGANIC AEROSOL; ALPHA-PINENE; UNITED-STATES; SESQUITERPENE
EMISSIONS; RADIOCARBON CONTENT; SOUTHEASTERN US; AMBIENT AEROSOL;
NORTH-CAROLINA; FOREST; VEGETATION
AB Carbonaceous particles smaller than 2.5 mu m aerodynamic diameter (PM(2.5)) were collected in July, 2003 over a Loblolly Pine plantation at Duke Forest, NC during the Chemical Emission, Loss, Transformation and Interactions within Canopies (CELTIC) field study. Organic (OC) and elemental (EC) carbon in PM(2.5) ranged from 1.4-6.3 and 0.08-0.41 mu g C m(-3), respectively, and concentrations measured above and below the pine canopy were in good agreement. Ambient OC was lower (<3 mu g C m(-3)) during cooler periods (daytime maximum temperatures < 28 degrees C) and for periods following precipitation events, and was higher (>3 mu g C m(-3)) during warm humid periods. Radiocarbon analysis indicates that on average 83% (range 78-91%) of the PM(2.5) carbon was derived from contemporary (biogenic VOC and biomass burning) sources. This is higher than previous estimates from urban and suburban sites, and in good agreement with recently published data from other rural sites throughout the U.S. The estimates of contemporary PM(2.5) carbon may represent a lower limit for this site since the sampler was located above the center of a 30 meter diameter plot fumigated with 200 ppm CO(2) derived from fossil carbon sources. However, this effect is likely to be negligible. The regression relationship between OC/EC ratios and percent biogenic carbon in aerosol is very similar to those observed in recent summertime data from Tennessee and Florida. However, our values for both OC/EC and percent biogenic carbon are higher than those observed in the latter studies, likely due to the more rural character of the site. Simple box model estimates indicate that biogenic VOC (BVOC) emissions measured at the site provide sufficient reactive carbon sources to account for the observed levels of aerosol biogenic carbon. The magnitude and temporal pattern in the box model secondary organic aerosol estimates correlate well with the ambient aerosol carbon measurements. The model estimates of the relative contribution of isoprene, alpha-pinene, and beta-caryophyllene oxidation to PM(2.5) carbon are in reasonable agreement with a study recently conducted at a nearby site where aerosol tracers of these compounds were quantitatively analyzed in ambient PM(2.5). Pinic acid concentrations in the below-canopy PM(2.5) during CELTIC (from another recently published study) similarly suggest a significant contribution of alpha-pinene oxidation to PM(2.5) carbon. The biomass burning tracers potassium and levoglucosan yielded fire contribution estimates to PM(2.5) consistent with their respective published emission factors. These estimates indicate that biomass burning accounted for 1 to 5% (0.015 to 0.30 mu g C m(-3)) of the PM(2.5) carbon during CELTIC. (C) 2010 Elsevier Ltd. All rights reserved.
C1 US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
RP Geron, C (reprint author), US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
EM geron.chris@epa.gov
OI Geron, Chris/0000-0002-4266-2155
FU Office of Science (BER); U.S. Department of Energy [DE-FG02-95ER62083]
FX The Duke Forest site was supported by the Office of Science (BER), U.S.
Department of Energy, Grant No. DE-FG02-95ER62083. Dr. Mike Hays (EPA
NRMRL) assisted in the OC/EC analysis. Dr. John T. Walker (USEPA/NRMRL)
provided the potassium and sulfate data used in the analysis. Dr. Jose
Fuentes (Penn State University) provided O3 data. David
Stiles of Alion Technologies provided assistance with the MSP
particulate sampler and in filter preparation as well. The author is
also thankful to Ram Oren and Heather McCarthy for providing leaf area
index data for the Duke Forest site. Mike Tufts of Arcadis, Inc.
performed QA tests of MSP particulate sampler performance. The late Dr.
Charles W. Lewis of EPA NERL provided much helpful insight and
discussion. Two anonymous reviewers provided excellent comments which
improved the quality and clarity of this paper.
NR 47
TC 4
Z9 4
U1 0
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD JAN
PY 2011
VL 45
IS 3
BP 794
EP 801
DI 10.1016/j.atmosenv.2010.07.015
PG 8
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 721GY
UT WOS:000287342800027
ER
PT J
AU Osborne, TZ
Newman, S
Scheidt, DJ
Kalla, PI
Bruland, GL
Cohen, MJ
Scinto, LJ
Ellis, LR
AF Osborne, Todd Z.
Newman, Susan
Scheidt, Daniel J.
Kalla, Peter I.
Bruland, Gregory L.
Cohen, Matthew J.
Scinto, Leonard J.
Ellis, Larry R.
TI Landscape Patterns of Significant Soil Nutrients and Contaminants in the
Greater Everglades Ecosystem: Past, Present, and Future
SO CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY
LA English
DT Review
DE Everglades; phosphorus; sulfur; carbon; mercury; soils; landscape
ID WATER CONSERVATION AREA; FLORIDA-EVERGLADES; NORTHERN EVERGLADES;
SPATIAL-DISTRIBUTION; SOUTH FLORIDA; PEAT SOILS; METHYLMERCURY
PRODUCTION; WETLAND ECOSYSTEM; TROPHIC GRADIENT; TOTAL PHOSPHORUS
AB The primary goal of this review and synthesis effort is to summarize present landscape patterns of key soil constituents such as carbon (C), phosphorus (P), sulfur (S), and mercury (Hg), all of which are of historical and present interest with respect to Everglades restoration. A secondary goal is to highlight the importance of landscape scale monitoring and assessment of soils in the Everglades Protection Area (EPA) with respect to present and future restoration efforts. Review of present information derived from the two independent landscape scale studies revealed significant patterns of soil thickness, organic matter, and P in the EPA. Two soil constituents of concern, Hg (biological toxicity) and S (linked to increased P cycling), also exhibit spatial patterns at the landscape scale, suggesting a need for focused efforts of restoration. Significant patterns of soil enrichment and change suggest a dynamic interaction between environmental stressors and soil biogeochemical properties across the landscape. Trends and patterns at the landscape scale in the EPA suggest that landscape scale monitoring and assessment is necessary and critical to determining the success of restoration efforts. However, several key questions, surrounding appropriate temporal and spatial sampling scales, the standardization of sampling methods, and the significance of short range variability must be addressed to facilitate future landscape scale assessment efforts.
C1 [Osborne, Todd Z.] Univ Florida, Soil & Water Sci Dept, Wetland Biogeochem Lab, Gainesville, FL USA.
[Newman, Susan] S Florida Water Management Dist, Everglades Div, Marsh Ecol Res Grp, W Palm Beach, FL USA.
[Scheidt, Daniel J.] US EPA, Water Protect Div, Atlanta, GA USA.
[Kalla, Peter I.] US EPA, Sci & Ecosyst Support Div, Atlanta, GA USA.
[Bruland, Gregory L.] Univ Hawaii Manoa, Dept Nat Resources & Environm Management, Honolulu, HI 96822 USA.
[Cohen, Matthew J.] Univ Florida, Sch Forest Resources & Conservat, Forest Water Resources Lab, Gainesville, FL 32611 USA.
[Scinto, Leonard J.] Florida Int Univ, SE Environm Res Ctr, Miami, FL 33199 USA.
[Ellis, Larry R.] Univ Florida, Soil & Water Sci Dept, Environm Pedol Lab, Gainesville, FL 32611 USA.
RP Osborne, TZ (reprint author), 106 Newell Hall,POB 110510, Gainesville, FL 32611 USA.
EM osbornet@ufl.edu
RI Cohen, Matthew/F-7117-2013;
OI Bruland, Gregory/0000-0002-3016-8088
NR 85
TC 9
Z9 9
U1 0
U2 33
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1064-3389
J9 CRIT REV ENV SCI TEC
JI Crit. Rev. Environ. Sci. Technol.
PY 2011
VL 41
SU 1
BP 121
EP 148
AR PII 933741586
DI 10.1080/10643389.2010.530930
PG 28
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 723GG
UT WOS:000287494000006
ER
PT J
AU Orem, W
Gilmour, C
Axelrad, D
Krabbenhoft, D
Scheidt, D
Kalla, P
McCormick, P
Gabriel, M
Aiken, G
AF Orem, William
Gilmour, Cynthia
Axelrad, Donald
Krabbenhoft, David
Scheidt, Daniel
Kalla, Peter
McCormick, Paul
Gabriel, Mark
Aiken, George
TI Sulfur in the South Florida Ecosystem: Distribution, Sources,
Biogeochemistry, Impacts, and Management for Restoration
SO CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY
LA English
DT Review
DE Everglades; methylmercury; sulfate; sulfur; water quality
ID CLADIUM-JAMAICENSE CYPERACEAE; FERTILIZER-DERIVED URANIUM; FRESH-WATER
WETLANDS; NEW-JERSEY PINELANDS; TYPHA-DOMINGENSIS; EVERGLADES
RESTORATION; NORTHERN EVERGLADES; HYDROGEN SULFIDE; TROPHIC GRADIENT;
SULFATE
AB Sulfur is broadly recognized as a water quality issue of significance for the freshwater Florida Everglades. Roughly 60% of the remnant Everglades has surface water sulfate concentrations above 1 mg l-1, a restoration performance measure based on present sulfate levels in unenriched areas. Highly enriched marshes in the northern Everglades have average sulfate levels of 60 mg l-1. Sulfate loading to the Everglades is principally a result of land and water management in South Florida. The highest concentrations of sulfate (average 60-70 mg l-1) in the ecosystem are in canal water in the Everglades Agricultural Area (EAA). Potential sulfur sourcesin the watershed are many, but geochemical data and a preliminary sulfur mass balance for the EAA are consistent with sulfur presently used in agricultural, and sulfur released by oxidation of organic EAA soils (including legacy agricultural applications and natural sulfur) as the primary sources of sulfate enrichment in the EAA canals. Sulfate loading to the Everglades increases microbial sulfate reduction in soils, leading to more reducing conditions, greater cycling of nutrients in soils, production of toxic sulfide, and enhanced methylmercury (MeHg) production and bioaccumulation. Wetlands are zones of naturally high MeHg production, but the combination of high atmospheric mercury deposition rates in South Florida and elevated sulfate loading leads to increased MeHg production and MeHg risk to Everglades wildlife and human consumers. Sulfate from the EAA drainage canals penetrates deep into the Everglades Water Conservation Areas, and may extend into Everglades National Park. Present plans to restore sheet flow and to deliver more water to the Everglades may increase overall sulfur loads to the ecosystem, and move sulfate-enriched water further south. However, water management practices that minimize soil drying and rewetting cycles can mitigate sulfate release during soil oxidation. A comprehensive Everglades restoration strategy should include reduction of sulfur loads as a goal because of the many detrimental impacts of sulfate on the ecosystem. Monitoring data show that the ecosystem response to changes in sulfate levels is rapid, and strategies for reducing sulfate loading may be effective in the near term. A multifaceted approach employing best management practices for sulfur in agriculture, agricultural practices that minimize soil oxidation, and changes to stormwater treatment areas that increase sulfate retention could help achieve reduced sulfate loads to the Everglades, with resulting benefits.
C1 [Orem, William] US Geol Survey, Reston, VA 20192 USA.
[Gilmour, Cynthia] Smithsonian Environm Res Ctr, Edgewater, MD 21037 USA.
[Axelrad, Donald] Florida Dept Environm Protect, Tallahassee, FL USA.
[Krabbenhoft, David] US Geol Survey, Middleton, WI USA.
[Scheidt, Daniel; Kalla, Peter] US EPA, Athens, GA USA.
[McCormick, Paul; Gabriel, Mark] S Florida Water Management Dist, W Palm Beach, FL USA.
[Aiken, George] US Geol Survey, Boulder, CO USA.
RP Orem, W (reprint author), US Geol Survey, 959 Natl Ctr, Reston, VA 20192 USA.
EM borem@usgs.gov
RI Gilmour, Cynthia/G-1784-2010
OI Gilmour, Cynthia/0000-0002-1720-9498
FU U.S. Geological Survey; U.S. Environmental Protection Agency; National
Park Service; Army Corps of Engineers; South Florida Water Management
District; Florida Department of Environmental Protection
FX The research described in this report was supported by funding from a
number of Federal and State agencies: the U.S. Geological Survey
(Priority Ecosystems Studies for South Florida-G. Ronnie Best, Program
Executive), the U.S. Environmental Protection Agency, the National Park
Service, the Army Corps of Engineers, the South Florida Water Management
District, and the Florida Department of Environmental Protection. The
authors thank Alan Kolker and Mark Engle from the USGS, Samira Daroub of
the University of Florida, Garth Redfield (South Florida Water
Management District), and one anonymous reviewer for their helpful
comments on the manuscript.
NR 130
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Z9 32
U1 6
U2 51
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1064-3389
J9 CRIT REV ENV SCI TEC
JI Crit. Rev. Environ. Sci. Technol.
PY 2011
VL 41
SU 1
BP 249
EP 288
AR PII 933735549
DI 10.1080/10643389.2010.531201
PG 40
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 723GG
UT WOS:000287494000010
ER
PT J
AU Lewis, MA
Goodman, LR
Chancy, CA
Jordan, SJ
AF Lewis, Michael A.
Goodman, Larry R.
Chancy, Cynthia A.
Jordan, Stephen J.
TI Fish Assemblages in Three Northwest Florida Urbanized Bayous before and
after Two Hurricanes
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Gulf of Mexico; bayous; fish assemblages; hurricanes
ID GULF-OF-MEXICO; QUALITY; ESTUARY; INDICATORS; SYSTEM
AB A 6-year survey (1993-1998) is summarized for fish collected from chemically contaminated, urbanized bayous in northwest Florida. Fifty-two monthly collections (January November) using trawls and seines occurred at 22 sites located in three adjacent bayous associated with the Pensacola Bay Estuary. Hurricanes Erin (Category 2) and Opal (Category 3) made landfall near the study area, and a state-wide entanglement net ban was initiated during the survey period. Approximately 585,000 fish were collected, which represented 80 species and 66 genera. The assemblages were dominated by estuarine-dependent and resident species similar to those commonly found in several nearby estuaries. Of these, Leiostomus xanthurus, Brevoortia patronus, Anchoa mitchilli, Lagodon rhomboides, and Menidia peninsulae composed 95% or more of the total catch. The total number of species for each collection ranged from 8 to 23, total abundances varied from 140 to 14,315 individuals, and Shannon diversity index values (H') were between 0.02 and 0.97. Mean species numbers and diversity index values were more consistent monthly than fish total abundance, which was influenced by seasonal occurrences of estuarine-dependent species. Hurricane effects were specific to the hurricane, structural parameter, species, and bayou. The posthurricane reductions in salinity (17% to 69%) and the few changes in fish abundance were usually temporary and within monthly and interannual variability. The resiliency of the fish assemblages to natural and anthropogenic stresses represents a survival advantage and readiness for future climatic change.
C1 [Lewis, Michael A.; Goodman, Larry R.; Chancy, Cynthia A.; Jordan, Stephen J.] US EPA, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, Gulf Breeze, FL 32561 USA.
RP Lewis, MA (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA.
EM lewis.michael@epa.gov
NR 41
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U1 1
U2 5
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD JAN
PY 2011
VL 27
IS 1
BP 35
EP 45
DI 10.2112/JCOASTRES-D-09-00019.1
PG 11
WC Environmental Sciences; Geography, Physical; Geosciences,
Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 716EW
UT WOS:000286952900004
ER
PT J
AU Xia, M
Craig, PM
Wallen, CM
Stoddard, A
Mandrup-Poulsen, J
Peng, MC
Schaeffer, B
Liu, ZJ
AF Xia, Meng
Craig, Paul M.
Wallen, Christopher M.
Stoddard, Andrew
Mandrup-Poulsen, Jan
Peng, Machuan
Schaeffer, Blake
Liu, Zhijun
TI Numerical Simulation of Salinity and Dissolved Oxygen at Perdido Bay and
Adjacent Coastal Ocean
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Perdido Bay; EFDC; plume; dissolved oxygen; salinity
ID WATER-QUALITY MODEL; RIVER ESTUARY; RAPPAHANNOCK RIVER; CHESAPEAKE BAY;
BOTTOM WATERS; HYPOXIA; EUTROPHICATION; SEA
AB Environmental fluid dynamic code (EFDC), a numerical estuarine and coastal ocean circulation hydrodynamic model, was used to simulate the distribution of the salinity, temperature, nutrients, and dissolved oxygen (DO) in Perdido Bay and adjacent Gulf of Mexico. External forcing factors included the coupled effects of the astronomical tides, river discharge, and atmospheric winds on the spatial and temporal distributions of salinity and DO. Modeled time series were in good agreement with field observations of water level, nutrients, temperature, salinity, and DO. Perdido Bay and adjacent northern Gulf of Mexico coasts can be divided into two areas according to salinity, water level, and DO concentrations. The first area was lower Perdido Bay and the associated Gulf of Mexico coasts, acting primarily under the influence of tidal forcing, which increases the vertical stratification. The second division was upper Perdido Bay, which was influenced by both tidal forcing and freshwater inflow. Simulations also indicated winds influenced the salinity and DO distributions, with an enhanced surface pressure gradient. Tidal effects were also important for conducting salinity and water quality simulations in Perdido Bay. Low amplitude tides induced relatively weak vertical mixing and favored the establishment of stratification at the bay, especially along deeper bathymetry. Flood tides influenced the distribution of salinity and DO more than ebb tides, specifically along shallow bathymetry.
C1 [Xia, Meng] Univ Michigan, Sch Nat Resources & Environm, Cooperat Inst Limnol & Ecosyst Res, Ann Arbor, MI 48108 USA.
[Xia, Meng; Craig, Paul M.; Wallen, Christopher M.; Stoddard, Andrew; Liu, Zhijun] Dynam Solut LLC, Knoxville, TN 37919 USA.
[Mandrup-Poulsen, Jan] Florida Dept Environm Protect, Tallahassee, FL 32399 USA.
[Peng, Machuan] N Carolina State Univ, Dept Marine Earth & Atmospher Sci, Raleigh, NC 27695 USA.
[Schaeffer, Blake] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, Gulf Breeze, FL 32563 USA.
RP Xia, M (reprint author), Univ Michigan, Sch Nat Resources & Environm, Cooperat Inst Limnol & Ecosyst Res, 4840 S State Rd, Ann Arbor, MI 48108 USA.
EM mengxia@umich.edu
FU Camp Dresser McKee Inc; NOAA's Great Lakes Environmental Research Lab
(GLERL); Cooperative Institute for Limnology and Ecosystem Research at
the University of Michigan
FX This study was supported by the Florida Department of Environmental
Protection through a subcontract from Camp Dresser & McKee Inc. Most
modeling activities were carried out by Dynamic Solutions LLC. We also
are thankful for the support of Ms. Julie Wallen, president of DSLLC,
and Mr. Jeffery Holt. Additionally support was provided by NOAA's Great
Lakes Environmental Research Lab (GLERL) and the Cooperative Institute
for Limnology and Ecosystem Research at the University of Michigan. Dr.
David J. Schwab and Ms. Cathy Darnell of NOAA GLERL helped edit the
manuscript, and Xiaoyan He helped revise the figures. This study has
been reviewed and approved for publication by the National Health and
Environmental Effects Research Laboratory, but contents are solely the
views of the authors. Mention of trade names or commercial products do
not constitute endorsement by the U.S. EPA or NOAA. This is contribution
number 1550 from the NOAA GLERL. This is also contribution number 1366
from the EPA Gulf Ecology Division.
NR 38
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U1 1
U2 29
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD JAN
PY 2011
VL 27
IS 1
BP 73
EP 86
DI 10.2112/JCOASTRES-D-09-00044.1
PG 14
WC Environmental Sciences; Geography, Physical; Geosciences,
Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 716EW
UT WOS:000286952900007
ER
PT J
AU Williams, MA
Egesten, A
AF Williams, Marc A.
Egesten, Arne
TI Allergic Inflammation: The Enemy Within
SO JOURNAL OF INNATE IMMUNITY
LA English
DT Editorial Material
C1 [Egesten, Arne] Lund Univ, Dept Clin Sci, SE-22184 Lund, Sweden.
[Williams, Marc A.] US EPA, EPHD Cardiopulm & Immunotoxicol Branch, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
RP Egesten, A (reprint author), Lund Univ, Dept Clin Sci, BMC B14 Tornavagen 10, SE-22184 Lund, Sweden.
EM Arne.Egesten@med.lu.se
NR 10
TC 0
Z9 0
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1662-811X
J9 J INNATE IMMUN
JI J. Innate Immun.
PY 2011
VL 3
IS 2
BP 111
EP 112
DI 10.1159/000323731
PG 2
WC Immunology
SC Immunology
GA 724EU
UT WOS:000287559700001
ER
PT J
AU Kalkstein, LS
Greene, S
Mills, DM
Samenow, J
AF Kalkstein, Laurence S.
Greene, Scott
Mills, David M.
Samenow, Jason
TI An evaluation of the progress in reducing heat-related human mortality
in major U.S. cities
SO NATURAL HAZARDS
LA English
DT Article
DE Climate and human health; Excessive heat event programs; Excess
mortality
ID WATCH-WARNING SYSTEM; US CITIES; DECADAL CHANGES; CLIMATE-CHANGE;
UNITED-STATES; IMPACTS; WAVES
AB This study estimates the excess mortality attributable to excessive heat events (EHEs) for forty major U.S. cities during 1975-1995 and 1975-2004. We calculate these results using the spatial synoptic classification method to identify EHE days. Step-wise regressions are then used to estimate the location-specific mortality algorithms that can account for the impact of the EHEs' duration, severity, and timing. Our excess mortality results are expressed both as lives lost and associated mortality rates (excess deaths per 100,000 residents) using 2000 Census population estimates. Our results generally show a reduction in EHE-attributable mortality rates since 1996. Adjusting our results to account for changes in the average number of EHE days per year in each period does not affect this general conclusion. However, this adjustment has a considerable impact on a measure of the cities' relative performance in terms of reducing this EHE-attributable excess mortality. Our results indicate there is promise for further reductions in EHE-attributable mortality from the approximately 1300 excess deaths per summer we identify using data from the 1975-2004 period. However, the magnitude of this result highlights the significant health burden of EHEs relative to other extreme weather events in the United States and suggests it is worthy of additional attention. Our results also raise important questions with respect to evaluating the performance of EHE notification and response programs and how EHE-attributable mortality should be estimated for future scenarios, notably for climate change projections.
C1 [Mills, David M.] Stratus Consulting Inc, Boulder, CO 80302 USA.
[Kalkstein, Laurence S.] Univ Miami, Dept Geog & Reg Studies, Marco Isl, FL 34145 USA.
[Kalkstein, Laurence S.] Appl Climatologists Inc, Marco Isl, FL 34145 USA.
[Greene, Scott] Univ Oklahoma, Dept Geog, Norman, OK 73019 USA.
[Greene, Scott] Oklahoma Wind Power Initiat, Norman, OK USA.
[Samenow, Jason] US EPA, Off Atmospher Programs, Climate Change Div, Washington, DC 20460 USA.
RP Mills, DM (reprint author), Stratus Consulting Inc, 1881 9th St,Suite 201, Boulder, CO 80302 USA.
EM larryk@miami.edu; jgreene@gcn.ou.edu; dmills@stratusconsulting.com;
Samenow.Jason@epamail.epa.gov
NR 23
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U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0921-030X
J9 NAT HAZARDS
JI Nat. Hazards
PD JAN
PY 2011
VL 56
IS 1
BP 113
EP 129
DI 10.1007/s11069-010-9552-3
PG 17
WC Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences;
Water Resources
SC Geology; Meteorology & Atmospheric Sciences; Water Resources
GA 711ZI
UT WOS:000286630600007
ER
PT J
AU Hassan, AA
Sorial, GA
AF Hassan, Ashraf Aly
Sorial, George A.
TI Treatment of dynamic mixture of hexane and benzene vapors in a Trickle
Bed Air Biofilter integrated with cyclic adsorption/desorption beds
SO CHEMOSPHERE
LA English
DT Article
DE Adsorption; Biofiltration; Biodegradation; Cyclic adsorption/desorption
bed; Fungi; Trickle Bed Air Biofilter (TBAB)
ID ELECTROTHERMAL SWING ADSORPTION; CARBON LOAD EQUALIZATION; ACTIVATED
CARBON; TRANSIENT-BEHAVIOR; TOLUENE REMOVAL; ORGANIC VAPOR; N-HEXANE;
PERFORMANCE; BIOFILTRATION; DESORPTION
AB One of the main challenges that face successful biofiltration is the erratic loading pattern and long starvation periods. However, such patterns are common in practical applications. In order to provide long-term stable operation of a biofilter under these conditions, a cyclic adsorption/desorption beds system with flow switching was installed prior to a biofilter. Different square waves of a mixture containing n-hexane and benzene at a 2:1 ratio were applied to the cyclic adsorption/desorption beds and then fed to a biofilter. The performance of this integrated system was compared to a biofilter unit receiving the same feed of both VOCs. The cyclic adsorption/desorption beds unit successfully achieved its goal of stabilizing erratic loading even with very sharp peaks at the influent concentration equalizing influent concentrations ranging from 10-470 ppmv for n-hexane to 30-1410 ppmv for benzene. The study included different peak concentrations with durations ranging from 6 to 20 min. The cyclic beds buffered the fluctuating influent load and the followed biofilter had all the time a continuous stable flow. Another advantage achieved by the cyclic adsorption/desorption beds was the uninterrupted feed to the biofilter even during the starvation where there was no influent in the feed. The results of the integrated system with regard to removal efficiency and kinetics are comparable to published results with continuous feed studies at the same loading rates. The removal efficiency for benzene had a minimum of 85% while for n-hexane ranged from 50% to 77% according to the loading rate. The control unit showed very erratic performance highlighting the benefit of the utilization of the cyclic adsorption/desorption beds. The biofilter was more adaptable to concentration changes in benzene than n-hexane. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Sorial, George A.] Univ Cincinnati, Sch Energy Environm Biol & Med Engn, Cincinnati, OH 45221 USA.
[Hassan, Ashraf Aly] US EPA, Cincinnati, OH USA.
RP Sorial, GA (reprint author), Univ Cincinnati, Sch Energy Environm Biol & Med Engn, 701 Engn Res Ctr,2624 Clifton Ave, Cincinnati, OH 45221 USA.
EM george.sorial@uc.edu
FU National Science Foundation [CBET 0852803]
FX The authors would like to thank the financial support from National
Science Foundation under Award # CBET 0852803. The finding and
conclusions expressed in this publication are solely those of the
authors and do not necessary reflect the views of the Foundation.
NR 37
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U1 0
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
J9 CHEMOSPHERE
JI Chemosphere
PD JAN
PY 2011
VL 82
IS 4
BP 521
EP 528
DI 10.1016/j.chemosphere.2010.10.060
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 714DS
UT WOS:000286788300006
ER
PT J
AU Jury, KL
Khan, SJ
Vancov, T
Stuetz, RM
Ashbolt, NJ
AF Jury, Karen L.
Khan, Stuart J.
Vancov, Tony
Stuetz, Richard M.
Ashbolt, Nicholas J.
TI Are Sewage Treatment Plants Promoting Antibiotic Resistance?
SO CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY
LA English
DT Review
DE antibiotic resistance; pharmaceutically active compounds; sewage
treatment plants
ID WASTE-WATER TREATMENT; BETA-LACTAM ANTIBIOTICS; MEDIATED QUINOLONE
RESISTANCE; TANDEM MASS-SPECTROMETRY; ESCHERICHIA-COLI; TETRACYCLINE
RESISTANCE; SULFONAMIDE RESISTANCE; ACTIVATED-SLUDGE;
STAPHYLOCOCCUS-AUREUS; DRUG-RESISTANCE
AB There is widespread speculation that sewage treatment plants (STPs) and aquatic environments in general may be breeding grounds for antibiotic resistant bacteria. We examine the question of whether low concentrations of antibiotics in STPs can provide or contribute to a selective pressure facilitating the acquisition or proliferation of antibiotic resistance among bacteria in the receiving environment. Examination of available literature suggests that relative levels of antibiotic resistance may be increased during sewage treatment processes. However, it is unclear whether this may be partially the result of horizontal gene transfer or entirely due to clonal propagation. While there is circumstantial evidence that the presence of antibiotics or other related genetic promoters in STP wastewaters may contribute to selective pressures for these processes, a definite role is yet to be demonstrated. Future researchers would benefit from the application of non-culture-based techniques because culture limits the possible observations to a small subset of STP microbial diversity.
C1 [Jury, Karen L.; Khan, Stuart J.; Vancov, Tony; Stuetz, Richard M.; Ashbolt, Nicholas J.] Univ New S Wales, UNSW Water Res Ctr, Sch Civil & Environm Engn, Sydney, NSW 2052, Australia.
[Jury, Karen L.; Vancov, Tony] Wollongbar Primary Ind Inst, Wollongbar, Australia.
[Ashbolt, Nicholas J.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
RP Khan, SJ (reprint author), Univ New S Wales, UNSW Water Res Ctr, Sch Civil & Environm Engn, Sydney, NSW 2052, Australia.
EM s.khan@unsw.edu.au
RI Khan, Stuart/E-7523-2012
OI Khan, Stuart/0000-0001-5147-145X
FU Australian Research Council [DP0558029]
FX This research was supported under Australian Research Council's
Discovery Projects funding scheme (project number DP0558029). The work
presented here has been subjected to the United States Environmental
Protection Agency review and approved for publication.
NR 141
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U1 6
U2 59
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1064-3389
J9 CRIT REV ENV SCI TEC
JI Crit. Rev. Environ. Sci. Technol.
PY 2011
VL 41
IS 3
BP 243
EP 270
AR PII 933053659
DI 10.1080/10643380902772589
PG 28
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 717FP
UT WOS:000287029200002
ER
PT J
AU Brattin, W
Griffin, S
AF Brattin, William
Griffin, Susan
TI Evaluation of the Contribution of Lead in Soil to Lead in Dust at
Superfund Sites
SO HUMAN AND ECOLOGICAL RISK ASSESSMENT
LA English
DT Article
DE lead; soil; dust; IEUBK
ID UPTAKE BIOKINETIC MODEL; CHILDREN
AB The concentration of lead in indoor dust is a key parameter in the Integrated Exposure Uptake Biokinetic (IEUBK) model used by the U.S. Environmental Protection Agency (USEPA) to evaluate risks to children from lead in soil. The default assumption is that the concentration of lead in indoor dust is 70% of the concentration of lead in outdoor soil. This report reviews the basis of this assumption, and compares the assumption to data obtained at mining/smelting Superfund sites in USEPA Region 8. Data for lead concentrations measured in both indoor dust and outdoor soil at a number of different properties at nine different Superfund sites were fit to a linear model (Cdust = K0 + Ksd center dot Csoil). Based on ordinary linear regression, values of Ksd ranged from 0.04 to 0.34. Values of Ksd estimated using a simple method to account for measurement errors yielded values from 0.04 to 0.35. These findings indicate that the concentration of lead in dust at mining/smelting sites in Region 8 is usually not as large as the IEUBK default assumption indicates. Use of the default is likely to be protective, but will likely result in an overestimation of childhood exposure and risk from lead in soil.
C1 [Griffin, Susan] US EPA, Denver, CO 80202 USA.
[Brattin, William] SRC Inc, Denver, CO USA.
RP Griffin, S (reprint author), US EPA, Reg 8,8OC EISC,1595 Wynkoop St, Denver, CO 80202 USA.
EM Griffin.susan@epa.gov
FU U.S. Environmental Protection Agency
FX Data used in this report were obtained by site investigations funded by
the U.S. Environmental Protection Agency Superfund Program.
NR 20
TC 0
Z9 1
U1 1
U2 6
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1080-7039
J9 HUM ECOL RISK ASSESS
JI Hum. Ecol. Risk Assess.
PY 2011
VL 17
IS 1
SI SI
BP 236
EP 244
AR PII 933408746
DI 10.1080/10807039.2011.538638
PG 9
WC Biodiversity Conservation; Environmental Sciences
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 720ZB
UT WOS:000287320100011
ER
PT J
AU Pickard, BC
Haas, AJ
Allgeier, SC
AF Pickard, Brian C.
Haas, Adam J.
Allgeier, Steven C.
TI Optimizing operational reliability of the Cincinnati contamination
warning system
SO JOURNAL AMERICAN WATER WORKS ASSOCIATION
LA English
DT Article
AB The US Environmental Protection Agency developed a contamination warning system (CWS) design with multiple, independent data streams to quickly detect unintentional or intentional contamination of drinking water distribution systems. During evaluation of the first full-scale pilot CWS in Cincinnati, Ohio, one primary design objective-optimizing operational reliability-was measured through two performance metrics: availability and data completeness. This evaluation was conducted to identify potential fail points, implement procedures to reduce downtime, and minimize lost or inaccurate data. Through two years of data collection and system optimization, the Cincinnati pilot CWS demonstrated continuous detection capabilities, even when some components or sub-components were nonfunctional. Subsequent distribution system modeling showed that the probability of experiencing a contamination incident while multiple components were nonfunctional was negligible. Overall, the optimized Cincinnati pilot CWS demonstrated robust operational reliability, with a high percentage of availability and data completeness.
C1 [Pickard, Brian C.] US EPA, Off Ground Water & Drinking Water, Water Secur Div, Washington, DC 20460 USA.
[Haas, Adam J.] CSC, Cincinnati, OH USA.
[Allgeier, Steven C.] US EPA, Cincinnati, OH 45268 USA.
RP Pickard, BC (reprint author), US EPA, Off Ground Water & Drinking Water, Water Secur Div, POB MC 4608T,1200 Penn Ave NW, Washington, DC 20460 USA.
EM pickard.brian@epa.gov
NR 11
TC 1
Z9 1
U1 0
U2 2
PU AMER WATER WORKS ASSOC
PI DENVER
PA 6666 W QUINCY AVE, DENVER, CO 80235 USA
SN 2164-4535
J9 J AM WATER WORKS ASS
JI J. Am. Water Work Assoc.
PD JAN
PY 2011
VL 103
IS 1
BP 60
EP +
PG 10
WC Engineering, Civil; Water Resources
SC Engineering; Water Resources
GA 710YY
UT WOS:000286554100016
ER
PT J
AU Meyer, DE
Curran, MA
Gonzalez, MA
AF Meyer, David E.
Curran, Mary Ann
Gonzalez, Michael A.
TI An examination of silver nanoparticles in socks using screening-level
life cycle assessment
SO JOURNAL OF NANOPARTICLE RESEARCH
LA English
DT Article
DE Silver nanoparticles; Nanomanufacturing; Screening-level life cycle
assessment; EH&S; Sustainable design; Consumer products
ID EXPOSURE
AB Screening-level life cycle assessment (LCA) can provide a quick tool to identify the life cycle hot spots and focus research efforts to help to minimize the burdens of a technology while maximizing its benefits. The use of nanoscale silver in consumer products has exploded in popularity. Although its use is considered beneficial because of antimicrobial effects, some attention must be given to the potential environmental impacts it could impart on the life cycle of these nanoproducts as production demands escalate. This work examines the environmental impact of including silver nanoparticles in commercially available socks using screening-level LCA. Initial results suggest washing during the use phase contributes substantially more than the manufacturing phase to the product life cycle impacts. Comparison of nanoparticles prepared by either chemical reduction, liquid flame spray (LFS), or plasma arc demonstrate how the type of manufacturing process used for the nanoscale silver can change the resulting life cycle impact of the sock product. The magnitude of this impact will depend on the type of process used to manufacture the nanoscale silver, with LFS having the most impact because of the need for large quantities of hydrogen and oxygen. Although the increased impacts for a single nanoproduct may be relatively small, the added environmental load can actually be a significant quantity when considered at the regional or global production level.
C1 [Meyer, David E.; Curran, Mary Ann; Gonzalez, Michael A.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Meyer, DE (reprint author), US EPA, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM meyer.david@epa.gov
OI Curran, Mary Ann/0000-0001-8565-9928
NR 28
TC 20
Z9 22
U1 2
U2 23
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1388-0764
J9 J NANOPART RES
JI J. Nanopart. Res.
PD JAN
PY 2011
VL 13
IS 1
BP 147
EP 156
DI 10.1007/s11051-010-0013-4
PG 10
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA 712LA
UT WOS:000286667000015
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PT J
AU Bahadori, T
Barr, D
Hubal, EC
AF Bahadori, Tina
Barr, Dana
Hubal, Elaine Cohen
TI From Servant to Luminary: Transforming Exposure Science for Protection
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SO EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT Joint Conference of
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ronmental-Epidemiology
CY AUG 28-SEP 01, 2010
CL Seoul, SOUTH KOREA
SP Int Soc Exposure Sci, Int Soc Environm Epidemiol
C1 [Bahadori, Tina] Amer Chem Council, Arlington, VA USA.
[Barr, Dana] Emory Univ, Atlanta, GA 30322 USA.
[Hubal, Elaine Cohen] US EPA, Res Triangle Pk, NC 27711 USA.
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PU LIPPINCOTT WILLIAMS & WILKINS
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EI 1531-5487
J9 EPIDEMIOLOGY
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PD JAN
PY 2011
VL 22
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SU S
BP S182
EP S182
DI 10.1097/01.ede.0000392237.06413.32
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GA 695VN
UT WOS:000285400800545
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PT J
AU Baxter, L
Teet, S
Neas, L
AF Baxter, Lisa
Teet, Stephen
Neas, Lucas
TI Identifying Cities for Enhanced Fine Particulate Matter Speciation
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DT Meeting Abstract
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Barzyk, T
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Turpin, B
Rich, D
Lunden, M
Hodas, N
Ozkaynak, H
AF Baxter, Lisa
Barzyk, Timothy
Burke, Janet
Turpin, Barbara
Rich, David
Lunden, Melissa
Hodas, Natasha
Ozkaynak, Haluk
TI Comparison of Exposures Estimated Using Ambient PM2.5 Concentrations
With Those Estimated by the Stochastic Human Exposure and Dose
Simulation Model for Two New Jersey Cohorts
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DT Meeting Abstract
CT Joint Conference of
International-Society-of-Exposure-Science/International-Society-for-Envi
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CY AUG 28-SEP 01, 2010
CL Seoul, SOUTH KOREA
SP Int Soc Exposure Sci, Int Soc Environm Epidemiol
C1 [Baxter, Lisa; Barzyk, Timothy; Burke, Janet; Ozkaynak, Haluk] US EPA, Res Triangle Pk, NC 27711 USA.
[Rich, David] UMDNJ Sch Publ Hlth, Piscataway, NJ USA.
[Turpin, Barbara; Hodas, Natasha] Rutgers State Univ, New Brunswick, NJ 08903 USA.
[Lunden, Melissa] Lawrence Berkeley Natl Lab, Berkeley, CA USA.
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AU Breville, M
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AU Cho, SH
Thornburg, J
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Dart, A
Johnson, C
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Long, R
Grover, B
AF Cho, Seung-Hyun
Thornburg, Jonathan
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Dart, Andrew
Johnson, Cortina
Vanderpool, Robert
Long, Russell
Grover, Bret
TI Influence of Spatial and Temporal Variability in Coarse and Fine
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SO EPIDEMIOLOGY
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DT Meeting Abstract
CT Joint Conference of
International-Society-of-Exposure-Science/International-Society-for-Envi
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CY AUG 28-SEP 01, 2010
CL Seoul, SOUTH KOREA
SP Int Soc Exposure Sci, Int Soc Environm Epidemiol
C1 [Cho, Seung-Hyun; Thornburg, Jonathan; Murdoch, Robert; Dart, Andrew; Johnson, Cortina] RTI Int, Res Triangle Pk, NC USA.
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CY AUG 28-SEP 01, 2010
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C1 [Johnson, Markey] Hlth Canada, Air Hlth Sci Div, Exposure Assessment Sect, Ottawa, ON K1A 0L2, Canada.
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Vedal, Sverre
Peel, Jennifer L.
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International-Society-of-Exposure-Science/International-Society-for-Envi
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CY AUG 28-SEP 01, 2010
CL Seoul, SOUTH KOREA
SP Int Soc Exposure Sci, Int Soc Environm Epidemiol
C1 [Kim, Sun-Young; Vedal, Sverre; Sheppard, Lianne] Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA.
[Peel, Jennifer L.] Colorado State Univ, Dept Environm & Radiol Hlth Sci, Ft Collins, CO 80523 USA.
[Hannigan, Michael P.] Univ Colorado, Dept Mech Engn, Boulder, CO 80309 USA.
[Dutton, Steven J.] US EPA, RTP, Res Triangle Pk, NC 27709 USA.
[Sheppard, Lianne] Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
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Yanosky, J
He, F
Rodriguez-Colon, S
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Cascio, W
AF Liao, Duanping
shaffer, Michele
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Yanosky, Jeff
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Rodriguez-Colon, Sol
Williams, Ronald
Cascio, Wayne
TI Acute Effects of Fine Particulate Air Pollution on Cardiac
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DT Meeting Abstract
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CY AUG 28-SEP 01, 2010
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C1 [Liao, Duanping; shaffer, Michele; Li, Xian; Yanosky, Jeff; He, Fan; Rodriguez-Colon, Sol] Penn State Univ, Coll Med, Hershey, PA USA.
[Williams, Ronald] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Cascio, Wayne] E Carolina Univ, Brody Sch Med, Greenville, NC USA.
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TI Comparison of Individual Food Analyses to Composites for Pyrethroid
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CT Joint Conference of
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CY AUG 28-SEP 01, 2010
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AF Meng, Qingyu
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TI Relationships Between Personal Exposure to Heat and Cold and Air
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AU Meyer, A
Parvez, S
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AF Meyer, Amy
Parvez, Shahid
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TI Analysis of Temporal and Spatial Variability in Disinfection By-product
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CY AUG 28-SEP 01, 2010
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C1 [Meyer, Amy] Oak Ridge Inst Sci & Educ, Cincinnati, OH USA.
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[Wright, Michael] US EPA, Cincinnati, OH 45268 USA.
RI Parvez, Shahid/J-3390-2013
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AF Nweke, Onyemaechi
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Kamat, L
Ohman-Strickland, P
Ozkaynak, H
Lunden, M
Barzyk, T
Burke, J
Baxter, L
Hodas, N
Turpin, B
AF Rich, David
Kamat, Leena
Ohman-Strickland, Pamela
Ozkaynak, Haluk
Lunden, Melissa
Barzyk, Timothy
Burke, Janet
Baxter, Lisa
Hodas, Natasha
Turpin, Barbara
TI Application of Refined Exposure Surrogates in Ambient PM2.5 Epidemiology
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Matter Infiltration
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CY AUG 28-SEP 01, 2010
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C1 [Rich, David; Kamat, Leena; Ohman-Strickland, Pamela] Univ Med & Dent New Jersey, Sch Publ Hlth, Piscataway, NJ 08854 USA.
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[Lunden, Melissa] Lawrence Berkeley Natl Labs, Berkeley, CA USA.
[Hodas, Natasha; Turpin, Barbara] Rutgers State Univ, Sch Biol & Environm Sci, New Brunswick, NJ 08903 USA.
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Sarnat, SE
Crooks, J
Isakov, V
Touma, J
Ozkaynak, H
Mulholland, J
Russell, A
Kewada, P
AF Sarnat, Jeremy A.
Sarnat, Stefanie Ebelt
Crooks, James
Isakov, Vlad
Touma, Joe
Ozkaynak, Haluk
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Russell, Armistead
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CY AUG 28-SEP 01, 2010
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C1 [Crooks, James; Isakov, Vlad; Touma, Joe; Ozkaynak, Haluk] US EPA, Res Triangle Pk, NC 27711 USA.
[Sarnat, Jeremy A.; Sarnat, Stefanie Ebelt; Kewada, Priya] Emory Univ, Atlanta, GA 30322 USA.
[Mulholland, James; Russell, Armistead] Georgia Inst Technol, Atlanta, GA 30332 USA.
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AF Starr, James
Stout, Daniel, II
Gemma, Anthony
TI Postapplication Formation of Pesticide Degradation Products in a Test
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CY AUG 28-SEP 01, 2010
CL Seoul, SOUTH KOREA
SP Int Soc Exposure Sci, Int Soc Environm Epidemiol
C1 [Starr, James; Stout, Daniel, II] US EPA, Natl Exposure Res Lab, RTP, Durham, NC USA.
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PU LIPPINCOTT WILLIAMS & WILKINS
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J9 EPIDEMIOLOGY
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SC Public, Environmental & Occupational Health
GA 695VN
UT WOS:000285400800702
ER
PT J
AU Starr, JM
Scollon, EJ
Hughes, MF
Graham, SE
Ross, DG
Crofton, KM
Wolansky, M
DeVito, MJ
Tornero-Velez, R
AF Starr, James M.
Scollon, Edward J.
Hughes, Michael F.
Graham, Stephen E.
Ross, David G.
Crofton, Kevin M.
Wolansky, Marcelo
DeVito, Michael J.
Tornero-Velez, Rogelio
TI Using a Chemical Mixture of Pyrethroid Pesticides to Determine Rodent
Tissue Clearance Rates
SO EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT Joint Conference of
International-Society-of-Exposure-Science/International-Society-for-Envi
ronmental-Epidemiology
CY AUG 28-SEP 01, 2010
CL Seoul, SOUTH KOREA
SP Int Soc Exposure Sci, Int Soc Environm Epidemiol
C1 [Starr, James M.; Tornero-Velez, Rogelio] US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC USA.
[Scollon, Edward J.; Hughes, Michael F.; Ross, David G.; Crofton, Kevin M.; Wolansky, Marcelo; DeVito, Michael J.] US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC USA.
[Scollon, Edward J.] US EPA, Div Hlth Effects, Off Pesticide Programs, Arlington, VA USA.
[Graham, Stephen E.] US EPA, Hlth & Environm Impacts Div, Off Air Qual Planning & Stand, Res Triangle Pk, NC USA.
[Wolansky, Marcelo] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Biol, Lab Toxicol Mezclas Quim LATOMEQ, Buenos Aires, DF, Argentina.
[DeVito, Michael J.] Natl Inst Environm Hlth Sci, Toxicol Branch, Natl Toxicol Program, Res Triangle Pk, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1044-3983
EI 1531-5487
J9 EPIDEMIOLOGY
JI Epidemiology
PD JAN
PY 2011
VL 22
IS 1
SU S
BP S249
EP S250
DI 10.1097/01.ede.0000392458.01615.b0
PG 2
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 695VN
UT WOS:000285400800766
ER
PT J
AU Tulve, N
Egeghy, P
Fortmann, R
Xue, JP
Evans, J
Whitaker, D
Croghan, C
AF Tulve, Nicolle
Egeghy, Peter
Fortmann, Roy
Xue, Jianping
Evans, Jeff
Whitaker, Donald
Croghan, Carry
TI Three Methodologies for Estimating Cumulative Human Exposures to
Current-use Pyrethroid Pesticides
SO EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT Joint Conference of
International-Society-of-Exposure-Science/International-Society-for-Envi
ronmental-Epidemiology
CY AUG 28-SEP 01, 2010
CL Seoul, SOUTH KOREA
SP Int Soc Exposure Sci, Int Soc Environm Epidemiol
C1 [Tulve, Nicolle; Egeghy, Peter; Fortmann, Roy; Xue, Jianping; Whitaker, Donald; Croghan, Carry] US EPA, Res Triangle Pk, NC 27711 USA.
[Evans, Jeff] US EPA, Washington, DC 20460 USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1044-3983
EI 1531-5487
J9 EPIDEMIOLOGY
JI Epidemiology
PD JAN
PY 2011
VL 22
IS 1
SU S
BP S88
EP S88
DI 10.1097/01.ede.0000391934.01974.c7
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 695VN
UT WOS:000285400800242
ER
PT J
AU Wright, JM
Rivera-Nunez, Z
AF Wright, J. Michael
Rivera-Nunez, Zorimar
TI The Effect of Disinfection By-products, Water Source, and Type of
Disinfection Treatment on Adverse Birth Outcomes in Massachusetts
SO EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT Joint Conference of
International-Society-of-Exposure-Science/International-Society-for-Envi
ronmental-Epidemiology
CY AUG 28-SEP 01, 2010
CL Seoul, SOUTH KOREA
SP Int Soc Exposure Sci, Int Soc Environm Epidemiol
C1 [Wright, J. Michael] US EPA, Natl Ctr Environm Assessment, Cincinnati, OH 45268 USA.
[Rivera-Nunez, Zorimar] CNR, Washington, DC 20418 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1044-3983
EI 1531-5487
J9 EPIDEMIOLOGY
JI Epidemiology
PD JAN
PY 2011
VL 22
IS 1
SU S
BP S68
EP S68
DI 10.1097/01.ede.0000391871.47922.b7
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 695VN
UT WOS:000285400800179
ER
PT J
AU Xue, JP
Zartarian, V
Liu, S
Geller, A
AF Xue, Jianping
Zartarian, Valerie
Liu, Shi
Geller, Andrew
TI Methyl Mercury Exposure in Tribal Populations From Fish Consumption:
Probabilistic SHEDS Model Analyses Using 1996-2006 NHANES and 1990-2003
Total Diet Survey Data
SO EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT Joint Conference of
International-Society-of-Exposure-Science/International-Society-for-Envi
ronmental-Epidemiology
CY AUG 28-SEP 01, 2010
CL Seoul, SOUTH KOREA
SP Int Soc Exposure Sci, Int Soc Environm Epidemiol
C1 [Xue, Jianping; Zartarian, Valerie; Liu, Shi; Geller, Andrew] US EPA, Res Triangle Pk, NC 27711 USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1044-3983
EI 1531-5487
J9 EPIDEMIOLOGY
JI Epidemiology
PD JAN
PY 2011
VL 22
IS 1
SU S
BP S183
EP S183
DI 10.1097/01.ede.0000392240.91165.5e
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 695VN
UT WOS:000285400800548
ER
PT J
AU Sonnemann, G
Vigon, B
Broadbent, C
Curran, MA
Finkbeiner, M
Frischknecht, R
Inaba, A
Schanssema, A
Stevenson, M
Ugaya, CML
Wang, HT
Wolf, MA
Valdivia, S
AF Sonnemann, Guido
Vigon, Bruce
Broadbent, Clare
Curran, Mary Ann
Finkbeiner, Matthias
Frischknecht, Rolf
Inaba, Atsushi
Schanssema, Aafko
Stevenson, Martha
Lie Ugaya, Cassia Maria
Wang, Hongtao
Wolf, Marc-Andree
Valdivia, Sonia
TI Process on "global guidance for LCA databases"
SO INTERNATIONAL JOURNAL OF LIFE CYCLE ASSESSMENT
LA English
DT Editorial Material
DE Global guidance; Life cycle assessment; Life cycle inventory; Pellston
workshop
C1 [Sonnemann, Guido; Stevenson, Martha; Wang, Hongtao] UNEP DTIE Paris, SCP Branch, F-75441 Paris 09, France.
[Wang, Hongtao] Sichuan Univ, Coll Architecture & Environm, Chengdu 610065, Peoples R China.
[Vigon, Bruce] SETAC N Amer, Pensacola, FL 32501 USA.
[Broadbent, Clare] World Steel Assoc, B-1140 Brussels, Belgium.
[Curran, Mary Ann] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
[Finkbeiner, Matthias] Tech Univ Berlin, Chair Sustainable Engn, Dept Environm Technol, D-10623 Berlin, Germany.
[Frischknecht, Rolf] ESU Serv Ltd, CH-8610 Uster, Switzerland.
[Inaba, Atsushi] Nat Inst Adv Ind Sci Technol AIST, Res Ctr Life Cycle Assessment, Tsukuba, Ibaraki 3058569, Japan.
[Wolf, Marc-Andree] Commiss European Communities, JRC, IES, Sustainabil Assessment Unit, I-21027 Ispra, Varcsc, Italy.
[Valdivia, Sonia] Sustainable Consumpt & Prod Branch, F-75009 Paris, France.
RP Sonnemann, G (reprint author), UNEP DTIE Paris, SCP Branch, 15 Rue Milan, F-75441 Paris 09, France.
EM guido.sonnemann@unep.org; martha.j.stevenson@gmail.com;
wanght.scu@gmail.com
OI Curran, Mary Ann/0000-0001-8565-9928
NR 0
TC 10
Z9 11
U1 4
U2 14
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0948-3349
J9 INT J LIFE CYCLE ASS
JI Int. J. Life Cycle Assess.
PD JAN
PY 2011
VL 16
IS 1
BP 95
EP 97
DI 10.1007/s11367-010-0243-9
PG 3
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 705AW
UT WOS:000286101300011
ER
PT B
AU Shao, Y
Taff, GN
Lunetta, RS
AF Shao, Yang
Taff, Gregory N.
Lunetta, Ross S.
BE Weng, Q
TI Review of Selected Moderate-Resolution Imaging Spectroradiometer
Algorithms, Data Products, and Applications
SO ADVANCES IN ENVIRONMENTAL REMOTE SENSING: SENSORS, ALGORITHMS, AND
APPLICATIONS
SE Taylor & Francis Series in Remote Sensing Applications
LA English
DT Article; Book Chapter
ID AEROSOL OPTICAL DEPTH; LEAF-AREA INDEX; SOUTHEASTERN UNITED-STATES;
LAND-COVER CLASSIFICATION; CENTRAL GREAT-PLAINS; REMOTELY-SENSED DATA;
MODIS-NDVI DATA; TIME-SERIES; SNOW-COVER; BIDIRECTIONAL REFLECTANCE
C1 [Shao, Yang] US EPA, Natl Res Council, Res Triangle Pk, NC 27711 USA.
[Taff, Gregory N.] Univ Memphis, Dept Earth Sci, Memphis, TN 38152 USA.
[Lunetta, Ross S.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Shao, Y (reprint author), US EPA, Natl Res Council, Res Triangle Pk, NC 27711 USA.
NR 128
TC 2
Z9 2
U1 0
U2 0
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4200-9181-6; 978-1-4200-9175-5
J9 T&F SER REMOTE SENS
PY 2011
BP 31
EP 55
D2 10.1201/b10599
PG 25
WC Environmental Sciences; Geosciences, Multidisciplinary; Remote Sensing
SC Environmental Sciences & Ecology; Geology; Remote Sensing
GA BC2WS
UT WOS:000351396200003
ER
PT J
AU Chang, WL
Bhave, PV
Brown, SS
Riemer, N
Stutz, J
Dabdub, D
AF Chang, Wayne L.
Bhave, Prakash V.
Brown, Steven S.
Riemer, Nicole
Stutz, Jochen
Dabdub, Donald
TI Heterogeneous Atmospheric Chemistry, Ambient Measurements, and Model
Calculations of N2O5: A Review
SO AEROSOL SCIENCE AND TECHNOLOGY
LA English
DT Article
ID RING-DOWN SPECTROSCOPY; NOCTURNAL BOUNDARY-LAYER; DIFFERENTIAL
OPTICAL-ABSORPTION; IONIZATION MASS-SPECTROMETRY; IN-SITU DETECTION;
LASER-INDUCED FLUORESCENCE; MINERAL DUST SURROGATES;
LIGHT-EMITTING-DIODES; LONG-TERM OBSERVATION; AIR-QUALITY MODELS
AB For several decades, dinitrogen pentoxide (N2O5) has been recognized as an important reactive intermediate in the atmospheric chemistry of nitrogen oxides and nitrate aerosol, especially during nighttime. However, due to the lack of ambient observations of N2O5, the nocturnal nitrogen oxide chemistry could not be quantified until recent years. The objective of the present article is to assess the current state-of-the-art knowledge of N2O5 dynamics within the tropospheric aerosol. An up-to-date summary of N2O5 chemistry and major loss mechanisms are provided. Furthermore, techniques for measuring ambient N2O5 and an overview of typical N2O5 levels in the troposphere are described. In addition, model representations of N2O5 chemistry are reviewed along with key features of N2O5 vertical profiles based on numerical simulations. Lastly, the article provides the outstanding uncertainties and needs for further research into the atmospheric chemistry of N2O5. These include the need for better characterization of N2O5 heterogeneous uptake under temperature conditions characteristic of mid-and high-latitude winter seasons; greater understanding of the influence of individual aerosol components on N2O5 uptake and representation of these components in atmospheric models; and comprehensive descriptions of nighttime vertical profiles of N2O5 and related pollutants.
C1 [Chang, Wayne L.; Dabdub, Donald] Univ Calif Irvine, Dept Mech & Aerosp Engn, Irvine, CA 92717 USA.
[Bhave, Prakash V.] US EPA, Res Triangle Pk, NC 27711 USA.
[Brown, Steven S.] Natl Ocean & Atmospher Adm, Earth Syst Res Lab, Boulder, CO USA.
[Riemer, Nicole] Univ Illinois, Dept Atmospher Sci, Urbana, IL 61801 USA.
[Stutz, Jochen] Univ Calif Los Angeles, Dept Atmospher & Ocean Sci, Los Angeles, CA USA.
RP Dabdub, D (reprint author), Univ Calif Irvine, Dept Mech & Aerosp Engn, Irvine, CA 92717 USA.
EM ddabdub@uci.edu
RI Brown, Steven/I-1762-2013; Bhave, Prakash/L-1958-2013; Stutz,
Jochen/K-7159-2014; Manager, CSD Publications/B-2789-2015
OI Bhave, Prakash/0000-0002-2573-951X;
FU California Air Resource Board (ARB)
FX This review article was motivated by a series of presentations at the
2007 International Aerosol Modeling Algorithms conference in Davis,
California. We are appreciative of funding from the California Air
Resource Board (ARB) and grateful to Dr. Ajith Kaduwala for his support.
The United States Environmental Protection Agency (US EPA) through its
Office of Research and Development collaborated in the research
described here. It has been subjected to Agency review and approved for
publication. We also thank Susan Forbes (US EPA) for her assistance with
literature searches, and William R. Simpson, Randy Apodaca, Timothy
Bertram, and Ezra Wood for providing several figures. Furthermore, we
extend our thanks to the reviewers for their invaluable constructive
comments and suggestions that have truly improved the quality of this
work.
NR 182
TC 73
Z9 75
U1 9
U2 108
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 520 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0278-6826
EI 1521-7388
J9 AEROSOL SCI TECH
JI Aerosol Sci. Technol.
PY 2011
VL 45
IS 6
BP 665
EP 695
DI 10.1080/02786826.2010.551672
PG 31
WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences;
Meteorology & Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA 730CG
UT WOS:000288007300001
ER
PT J
AU Kumar, N
Chu, AD
Foster, AD
Peters, T
Willis, R
AF Kumar, Naresh
Chu, Allen D.
Foster, Andrew D.
Peters, Thomas
Willis, Robert
TI Satellite Remote Sensing for Developing Time and Space Resolved
Estimates of Ambient Particulate in Cleveland, OH
SO AEROSOL SCIENCE AND TECHNOLOGY
LA English
DT Article
ID AEROSOL OPTICAL DEPTH; AIR-QUALITY; MODIS; VALIDATION; POLLUTION; PM2.5;
LAND; RETRIEVAL; THICKNESS; MATTER
AB This article empirically demonstrates the use of fine resolution satellite-based aerosol optical depth (AOD) to develop time and space resolved estimates of ambient particulate matter (PM) <= 2.5 mu m and <= 10 mu m in aerodynamic diameters (PM2.5 and PM10, respectively). AOD was computed at three different spatial resolutions, i.e., 2 km (means 2 km x 2 km area at nadir), 5 km, and 10 km, by using the data from MODerate Resolution Imaging Spectroradiometer (MODIS), aboard the Terra and Aqua satellites. Multiresolution AOD from MODIS (AOD(MODIS)) was compared with the in situ measurements of AOD by NASA's AErosol RObotic NETwork (AERONET) sunphotometer (AOD(AERONET)) at Bondville, IL, to demonstrate the advantages of the fine resolution AODMODIS over the 10-km AOD(MODIS), especially for air quality prediction. An instrumental regression that corrects AOD(MODIS) for meteorological conditions was used for developing a PM predictive model.
The 2-km AOD(MODIS) aggregated within 0.025 degrees and 15-min intervals shows the best association with the in situ measurements of AOD(AERONET). The 2-km AOD(MODIS) seems more promising to estimate time and space resolved estimates of ambient PM than the 10-km AOD(MODIS), because of better location precision and a significantly greater number of data points across geographic space and time. Utilizing the collocated AOD(MODIS) and PM data in Cleveland, OH, a regression model was developed for predicting PM for all AOD(MODIS) data points. Our analysis suggests that the slope of the 2-km AOD(MODIS) (instrumented on meteorological conditions) is close to unity with the PM monitored on the ground. These results should be interpreted with caution, because the slope of AOD(MODIS) ranges from 0.52 to 1.72 in the site-specific models. In the cross validation of the overall model, the root mean square error (RMSE) of PM10 was smaller (2.04 mu g/m(3) in overall model) than that of PM2.5 (2.5 mu g/m(3)). The predicted PM in the AODMODIS data (similar to 2.34 million data points) was utilized to develop a systematic grid of daily PM at 5-km spatial resolution with the aid of spatiotemporal Kriging.
C1 [Kumar, Naresh] Univ Iowa, Dept Geog, Iowa City, IA 52242 USA.
[Chu, Allen D.] NASA, Goddard Space Flight Ctr, Washington, DC 20546 USA.
[Foster, Andrew D.] Brown Univ, Providence, RI 02912 USA.
[Peters, Thomas] Univ Iowa, Dept Occupat & Environm Hlth, Iowa City, IA USA.
[Willis, Robert] US EPA, Res Triangle Pk, NC 27711 USA.
RP Kumar, N (reprint author), Univ Iowa, Dept Geog, 316 Jessup Hall, Iowa City, IA 52242 USA.
EM naresh-kumar@uiowa.edu
RI Wang, Linden/M-6617-2014
FU United States Environmental Protection Agency through its Office of
Research and Development [RFQ-RT-10-00204]; NIH [R21 ES014004-01A2]; EPA
[RFQ-RT-10-00204, R833865]
FX The United States Environmental Protection Agency through its Office of
Research and Development partially funded and collaborated in the
research described here under RFQ-RT-10-00204 to the University of Iowa.
It has been subjected to Agency Review and approved for publication.;
This research was supported by NIH (R21 ES014004-01A2) and EPA (R833865;
RFQ-RT-10-00204). We would like to thank the two anonymous referees for
providing us with constructive comments and suggestions that allowed us
to improve the quality of the initial sub-mission.
NR 33
TC 26
Z9 27
U1 0
U2 19
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0278-6826
EI 1521-7388
J9 AEROSOL SCI TECH
JI Aerosol Sci. Technol.
PY 2011
VL 45
IS 9
BP 1090
EP 1108
DI 10.1080/02786826.2011.581256
PG 19
WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences;
Meteorology & Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA 776IR
UT WOS:000291528200005
PM 22238503
ER
PT J
AU Crofton, KM
Mundy, WR
Lein, PJ
Bal-Price, A
Coecke, S
Seiler, AEM
Knaut, H
Buzanska, L
Goldberg, A
AF Crofton, Kevin M.
Mundy, William R.
Lein, Pamela J.
Bal-Price, Anna
Coecke, Sandra
Seiler, Andrea E. M.
Knaut, Holger
Buzanska, Leonora
Goldberg, Alan
TI Developmental Neurotoxicity Testing: Recommendations for Developing
Alternative Methods for the Screening and Prioritization of Chemicals
SO ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
LA English
DT Article
DE developmental neurotoxicity; screening; in vitro models
ID NEURITE OUTGROWTH; IN-VITRO; HIGH-THROUGHPUT; RISK-ASSESSMENT; PC12
CELLS; CULTURES; VALIDATION; VIABILITY; VALIDITY; NEURON
AB Developmental neurotoxicity testing (DNT) is perceived by many stakeholders to be an area in critical need of alternative methods to current animal testing protocols and guidelines. An immediate goal is to develop test methods that are capable of screening large numbers of chemicals. This document provides recommendations for developing alternative DNT approaches that will generate the type of data required for evaluating and comparing predictive capacity and efficiency across test methods and laboratories. These recommendations were originally drafted to stimulate and focus discussions of alternative testing methods and models for DNT at the TestSmart DNT II meeting (http://caat.jhsph.edu/programs/workshops/dnt2.html) and this document reflects critical feedback from all stakeholders that participated in this meeting. The intent of this document is to serve as a catalyst for engaging the research community in the development of DNT alternatives and it is expected that these recommendations will continue to evolve with the science.
C1 [Crofton, Kevin M.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Lein, Pamela J.] Univ Calif Davis, UC Davis Sch Vet Med, Davis, CA 95616 USA.
[Bal-Price, Anna; Coecke, Sandra; Knaut, Holger] European Ctr Validat Alternat Methods ECVAM, European Commiss Joint Res Ctr, Inst Hlth & Consumer Protect, In Vitro Methods Unit, Ispra, Italy.
[Seiler, Andrea E. M.] Ctr Alternat Methods Anim Expt ZEBET, Fed Inst Risk Assessment BfR, Berlin, Germany.
[Buzanska, Leonora] Polish Acad Sci, Mossakowski Med Res Ctr, Warsaw, Poland.
Johns Hopkins Univ, Ctr Alternat Anim Testing, Baltimore, MD USA.
RP Crofton, KM (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, MD B105-04, Res Triangle Pk, NC 27711 USA.
EM crofton.kevin@epamail.epa.gov
RI Crofton, Kevin/J-4798-2015
OI Crofton, Kevin/0000-0003-1749-9971
NR 32
TC 55
Z9 55
U1 0
U2 7
PU SPEKTRUM AKAD VERLAG
PI HEIDELBERG
PA SLEVOGTSTRASSE 3-5, D-69126 HEIDELBERG, GERMANY
SN 1868-596X
J9 ALTEX-ALTERN ANIM EX
JI ALTEX-Altern. Anim. Exp.
PY 2011
VL 28
IS 1
BP 9
EP 15
PG 7
WC Instruments & Instrumentation; Medicine, Research & Experimental
SC Instruments & Instrumentation; Research & Experimental Medicine
GA 734SQ
UT WOS:000288358600003
PM 21311847
ER
PT J
AU Hartung, T
Blaauboer, BJ
Bosgra, S
Carney, E
Coenen, J
Conolly, RB
Corsini, E
Green, S
Faustman, EM
Gaspari, A
Hayashi, M
Hayes, AW
Hengstler, JG
Knudsen, LE
Knudsen, TB
McKim, JM
Pfaller, W
Roggen, EL
AF Hartung, Thomas
Blaauboer, Bas J.
Bosgra, Sieto
Carney, Edward
Coenen, Joachim
Conolly, Rory B.
Corsini, Emanuela
Green, Sidney
Faustman, Elaine M.
Gaspari, Anthony
Hayashi, Makoto
Hayes, A. Wallace
Hengstler, Jan G.
Knudsen, Lisbeth E.
Knudsen, Thomas B.
McKim, James M.
Pfaller, Walter
Roggen, Erwin L.
TI An Expert Consortium Review of the EC-commissioned Report "Alternative
(Non-Animal) Methods for Cosmetics Testing: Current Status and Future
Prospects-2010"
SO ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
LA English
DT Review
DE alternatives to animal testing; 3Rs; toxicology; novel approaches;
product safety
ID MOUSE EMBRYONIC FIBROBLAST; IN-VITRO; EPITHELIAL-CELLS; REPRODUCTIVE
TOXICITY; IMMUNOTOXICITY; CHEMICALS; ACTIVATION; EXPRESSION; PREDICTION;
EXPOSURE
AB The European cosmetics legislation foresees a review in 2011 and possible postponement of the 2013 marketing ban to enforce the testing ban for systemic and repeated-dose animal tests. For this purpose, a 119-page report commissioned by the European Commission was published recently. Here, a group of
17 independent experts from the US, Europe, and Japan was brought together to evaluate the report. The expert panel strongly endorsed the report and its conclusions. A number of important options not considered were identified; these do not, however, affect the overall conclusions regarding the current lack of availability of a full replacement, especially for the areas of repeated dose toxicity, carcinogenicity testing, and reproductive toxicity, though a roadmap for change is emerging. However, some of these options may provide adequate data for replacement of some animal studies in the near future pending validation. Various recommendations expand the original report. The reviewers agree with the report that there is greater promise in the short term for the areas of sensitization and toxicokinetics. Additional opportunities lie in more global collaborations and the inclusion of other industry sectors.
C1 [Hartung, Thomas] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, CAAT, Baltimore, MD USA.
[Hartung, Thomas] Univ Konstanz, CAAT Europe, D-7750 Constance, Germany.
[Blaauboer, Bas J.] Univ Utrecht, Doerenkamp Zbinden Chair Alternat Anim Testing To, Inst Risk Assessment Sci, Div Toxicol, NL-3508 TC Utrecht, Netherlands.
[Bosgra, Sieto] TNO, Utrecht, Netherlands.
[Carney, Edward] Dow Chem Co USA, Predict Toxicol, Midland, MI 48674 USA.
[Coenen, Joachim] Merck Serono, Anim Sci & Welf, R&D Qual Assurance Darmstadt, Darmstadt, Germany.
[Conolly, Rory B.] US EPA, Integrated Syst Toxicol Div, Res Triangle Pk, NC 27711 USA.
[Corsini, Emanuela] Univ Milan, Sch Pharm, I-20122 Milan, Italy.
[Green, Sidney] Howard Univ, Coll Med, Dept Pharmacol, Washington, DC 20059 USA.
[Faustman, Elaine M.] Univ Washington, Dept Environm & Occupat Hlth Sci, Inst Risk Anal & Risk Commun, Seattle, WA 98195 USA.
[Gaspari, Anthony] Univ Maryland, Sch Med, Dept Dermatol, Baltimore, MD 21201 USA.
[Hayashi, Makoto] Biosafety Res Ctr, Shizuoka, Japan.
[Hayes, A. Wallace] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA.
[Hengstler, Jan G.] TU Dortmund, Leibniz Res Ctr IfADo, Dortmund, Germany.
[Knudsen, Lisbeth E.] Univ Copenhagen, Fac Hlth Sci, Dept Publ Hlth, Copenhagen, Denmark.
[Knudsen, Thomas B.] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA.
[McKim, James M.] CeeTox Inc, Kalamazoo, MI USA.
[Pfaller, Walter] Innsbruck Med Univ, Dept Physiol & Med Phys, Div Physiol, Innsbruck, Austria.
[Roggen, Erwin L.] Novozymes AS, Bagsvaerd, Denmark.
RP Hartung, T (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Alternat Anim Testing, 615 N Wolfe St, Baltimore, MD 21205 USA.
EM THartung@jhsph.edu
RI pfaller, walter/A-8803-2010; Hengstler, Jan/O-1415-2013;
OI Knudsen, Lisbeth E./0000-0002-9576-1202
FU Doerenkamp-Zbinden Foundation
FX a report of t4 - the transatlantic think tank for toxicology,
a collaboration of the toxicolgically oriented chairs in Baltimore,
Konstanz and Utrecht sponsored by the Doerenkamp-Zbinden Foundation
NR 47
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U1 2
U2 15
PU SPEKTRUM AKAD VERLAG
PI HEIDELBERG
PA SLEVOGTSTRASSE 3-5, D-69126 HEIDELBERG, GERMANY
SN 1868-596X
J9 ALTEX-ALTERN ANIM EX
JI ALTEX-Altern. Anim. Exp.
PY 2011
VL 28
IS 3
BP 183
EP 209
PG 27
WC Instruments & Instrumentation; Medicine, Research & Experimental
SC Instruments & Instrumentation; Research & Experimental Medicine
GA 829IZ
UT WOS:000295573100003
PM 21993956
ER
PT J
AU Silbergeld, EK
Contreras, EQ
Hartung, T
Hirsch, C
Hogberg, H
Jachak, AC
Jordan, W
Landsiedel, R
Morris, J
Patri, A
Pounds, JG
Ruiz, AD
Shvedova, A
Tanguay, R
Tatarazako, N
van Vliet, E
Walker, NJ
Wiesner, M
Wilcox, N
Zurlo, J
AF Silbergeld, Ellen K.
Contreras, Elizabeth Q.
Hartung, Thomas
Hirsch, Cordula
Hogberg, Helena
Jachak, Ashish C.
Jordan, William
Landsiedel, Robert
Morris, Jeffery
Patri, Anil
Pounds, Joel G.
de Vizcaya Ruiz, Andrea
Shvedova, Anna
Tanguay, Robert
Tatarazako, Norihasa
van Vliet, Erwin
Walker, Nigel J.
Wiesner, Mark
Wilcox, Neil
Zurlo, Joanne
TI Nanotoxicology: "The End of the Beginning" - Signs on the Roadmap to a
Strategy for Assuring the Safe Application and Use of Nanomaterials
SO ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
LA English
DT Article
DE nanomaterials; nanotoxicology; alternative methods; 3Rs; Tox-21c
AB In October 2010, a group of experts met as part of the transatlantic think tank for toxicology (t(4)) to exchange ideas about the current status and future of safety testing of nanomaterials. At present, there is no widely accepted path forward to assure appropriate and effective hazard identification for engineered nanomaterials. The group discussed needs for characterization of nanomaterials and identified testing protocols that incorporate the use of innovative alternative whole models such as zebrafish or C. elegans, as well as in vitro or alternative methods to examine specific functional pathways and modes of action. The group proposed elements of a potential testing scheme for nanomaterials that works towards an integrated testing strategy, incorporating the goals of the NRC report Toxicity Testing in the 21(st) Century: A Vision and a Strategy by focusing on pathways of toxic response, and utilizing an evidence-based strategy for developing the knowledge base for safety assessment. Finally, the group recommended that a reliable, open, curated database be developed that interfaces with existing databases to enable sharing of information.
C1 [Silbergeld, Ellen K.; Jachak, Ashish C.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD USA.
[Contreras, Elizabeth Q.] Rice Univ, Dept Chem, Houston, TX USA.
[Hartung, Thomas; Hogberg, Helena; van Vliet, Erwin; Zurlo, Joanne] Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Alternat Anim Testing, Baltimore, MD USA.
[Hirsch, Cordula] Empa Swiss Fed Labs Mat Sci & Technol, St Gallen, Switzerland.
[Jordan, William; Morris, Jeffery] US EPA, Washington, DC 20460 USA.
[Landsiedel, Robert] BASF, Ludwigshafen, Germany.
[Patri, Anil] NCI, Nanotechnol Characterizat Lab, NIH, Frederick, MD 21701 USA.
[Pounds, Joel G.] Pacific NW Natl Lab, Richland, WA 99352 USA.
[de Vizcaya Ruiz, Andrea] CINVESTAV, Mexico City 14000, DF, Mexico.
[Shvedova, Anna] CDC, Natl Inst Occupat Safety & Hlth, Morgantown, WV USA.
[Tanguay, Robert] Oregon State Univ, Dept Environm & Mol Toxicol, Corvallis, OR 97331 USA.
[Tatarazako, Norihasa] Natl Inst Environm Sci, Tsukuba, Ibaraki, Japan.
[Walker, Nigel J.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
[Walker, Nigel J.] NIEHS, Natl Toxicol Program, Res Triangle Pk, NC 27709 USA.
[Wiesner, Mark] Duke Univ, Dept Civil & Environm Engn, Durham, NC 27706 USA.
[Wilcox, Neil] US FDA, Off Cosmet & Colors, Ctr Food Safety & Appl Nutr, College Pk, MD USA.
RP Zurlo, J (reprint author), Johns Hopkins Ctr Alternat Anim Testing, 615 N Wolfe St,W7032, Baltimore, MD 21205 USA.
EM jzurlo@jhsph.edu
RI Landsiedel, Robert/D-1960-2012; Walker, Nigel/D-6583-2012;
Nanotechnology Characterization Lab, NCL/K-8454-2012
OI Landsiedel, Robert/0000-0003-3756-1904; Walker,
Nigel/0000-0002-9111-6855;
FU Doerenkamp-Zbinden Foundation
FX We thank the Doerenkamp-Zbinden Foundation for sponsoring this workshop
as part of the t4 activities.
NR 5
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U2 11
PU SPEKTRUM AKAD VERLAG
PI HEIDELBERG
PA SLEVOGTSTRASSE 3-5, D-69126 HEIDELBERG, GERMANY
SN 1868-596X
J9 ALTEX-ALTERN ANIM EX
JI ALTEX-Altern. Anim. Exp.
PY 2011
VL 28
IS 3
BP 236
EP 241
PG 6
WC Instruments & Instrumentation; Medicine, Research & Experimental
SC Instruments & Instrumentation; Research & Experimental Medicine
GA 829IZ
UT WOS:000295573100006
PM 21993959
ER
PT J
AU Waggoner, JK
Kullman, GJ
Henneberger, PK
Umbach, DM
Blair, A
Alavanja, MCR
Kamel, F
Lynch, CF
Knott, C
London, SJ
Hines, CJ
Thomas, KW
Sandler, DP
Lubin, JH
Freeman, LE
Hoppin, JA
AF Waggoner, Jenna K.
Kullman, Greg J.
Henneberger, Paul K.
Umbach, David M.
Blair, Aaron
Alavanja, Michael C. R.
Kamel, Freya
Lynch, Charles F.
Knott, Charles
London, Stephanie J.
Hines, Cynthia J.
Thomas, Kent W.
Sandler, Dale P.
Lubin, Jay H.
Beane Freeman, Laura E.
Hoppin, Jane A.
TI Mortality in the Agricultural Health Study, 1993-2007
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE agriculture; healthy worker effect; mortality; neoplasms; pesticides;
wounds and injuries
ID PESTICIDE APPLICATORS; PROSTATE-CANCER; INJURY MORTALITY; UNITED-STATES;
FARMERS; RISK; EXPOSURE; METAANALYSES; COHORT; WIVES
AB Comparing agricultural cohorts with the general population is challenging because the general healthiness of farmers may mask potential adverse health effects of farming. Using data from the Agricultural Health Study, a cohort of 89,656 pesticide applicators and their spouses (N = 89, 656) in North Carolina and Iowa, the authors computed standardized mortality ratios (SMRs) comparing deaths from time of the enrollment (1993-1997) through 2007 to state-specific rates. To compensate for the cohort's overall healthiness, relative SMRs were estimated by calculating the SMR for each cause relative to the SMR for all other causes. In 1,198,129 person-years of follow-up, 6,419 deaths were observed. The all-cause mortality rate was less than expected (SMRapplicators = 0.54, 95% confidence interval (CI): 0.52, 0.55; SMRspouses = 0.52, 95% CI: 0.50, 0.55). SMRs for all cancers, heart disease, and diabetes were significantly below 1.0. In contrast, applicators experienced elevated numbers of machine-related deaths (SMR = 4.15, 95% CI: 3.18, 5.31), motor vehicle nontraffic accidents (SMR = 2.80, 95% CI: 1.81, 4.14), and collisions with objects (SMR = 2.12, 95% CI: 1.25, 3.34). In the relative SMR analysis for applicators, the relative mortality ratio was elevated for lymphohematopoietic cancers, melanoma, and digestive system, prostate, kidney, and brain cancers. Among spouses, relative SMRs exceeded 1.0 for lymphohematopoietic cancers and malignancies of the digestive system, brain, breast, and ovary. Unintentional fatal injuries remain an important risk for farmers; mortality ratios from several cancers were elevated relative to other causes.
C1 [Waggoner, Jenna K.; Kamel, Freya; London, Stephanie J.; Sandler, Dale P.; Hoppin, Jane A.] NIEHS, Epidemiol Branch, Res Triangle Pk, NC 27709 USA.
[Waggoner, Jenna K.; Kullman, Greg J.; Henneberger, Paul K.] NIOSH, Div Resp Dis Studies, Morgantown, WV 26505 USA.
[Umbach, David M.] NIEHS, Biostat Branch, Res Triangle Pk, NC 27709 USA.
[Blair, Aaron; Alavanja, Michael C. R.; Lubin, Jay H.; Beane Freeman, Laura E.] NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
[Lynch, Charles F.] Univ Iowa, Dept Epidemiol, Iowa City, IA USA.
[Knott, Charles] Battelle Mem Inst, Durham, NC USA.
[Hines, Cynthia J.] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH 45226 USA.
[Thomas, Kent W.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Hoppin, JA (reprint author), NIEHS, Epidemiol Branch, MD A3-05,POB 12233, Res Triangle Pk, NC 27709 USA.
EM hoppin1@niehs.nih.gov
RI Beane Freeman, Laura/C-4468-2015;
OI Beane Freeman, Laura/0000-0003-1294-4124; Kamel,
Freya/0000-0001-5052-6615; London, Stephanie/0000-0003-4911-5290;
Sandler, Dale/0000-0002-6776-0018
FU Association of Schools of Public Health/Centers for Disease Control;
National Institute for Occupational Safety and Health; National
Institutes of Health; National Institutes of Health, National Institute
of Environmental Health Sciences [Z01-ES049030]; National Institutes of
Health National Cancer Institute [Z01-CP010119]
FX This work was supported by the Association of Schools of Public
Health/Centers for Disease Control fellowship program; the National
Institute for Occupational Safety and Health; the Intramural Research
Program of the National Institutes of Health; and the Intramural
Research Program of the National Institutes of Health, National
Institute of Environmental Health Sciences (Z01-ES049030) and the
National Institutes of Health National Cancer Institute (Z01-CP010119).
NR 42
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U1 0
U2 19
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JAN 1
PY 2011
VL 173
IS 1
BP 71
EP 83
DI 10.1093/aje/kwq323
PG 13
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 695ZR
UT WOS:000285412200008
PM 21084556
ER
PT J
AU Adamkiewicz, G
Zota, AR
Fabian, MP
Chahine, T
Julien, R
Spengler, JD
Levy, JI
AF Adamkiewicz, Gary
Zota, Ami R.
Fabian, M. Patricia
Chahine, Teresa
Julien, Rhona
Spengler, John D.
Levy, Jonathan I.
TI Moving Environmental Justice Indoors: Understanding Structural
Influences on Residential Exposure Patterns in Low-Income Communities
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
ID AMBIENT AIR TOXICS; SOCIOECONOMIC-STATUS; NITROGEN-DIOXIDE; ALLERGEN
CONCENTRATIONS; ASTHMATIC-CHILDREN; PARTICULATE MATTER; BUILT
ENVIRONMENT; SUBURBAN HOMES; UNITED-STATES; MENTAL-HEALTH
AB Objectives. The indoor environment has not been fully incorporated into the environmental justice dialogue. To inform strategies to reduce disparities, we developed a framework to identify the individual and place-based drivers of indoor environment quality.
Methods. We reviewed empirical evidence of socioeconomic disparities in indoor exposures and key determinants of these exposures for air pollutants, lead, allergens, and semivolatile organic compounds. We also used an indoor air quality model applied to multifamily housing to illustrate how nitrogen dioxide (NO(2)) and fine particulate matter (PM(2.5)) vary as a function of factors known to be influenced by socioeconomic status.
Results. Indoor concentrations of multiple pollutants are elevated in low-socioeconomic status households. Differences in these exposures are driven by the combined influences of indoor sources, outdoor sources, physical structures, and residential activity patterns. Simulation models confirmed indoor sources' importance in determining indoor NO(2) and PM(2.5) exposures and showed the influence of household-specific determinants.
Conclusions. Both theoretical models and empirical evidence emphasized that disparities in indoor environmental exposure can be significant. Understanding key determinants of multiple indoor exposures can aid in developing policies to reduce these disparities. (Am J Public Health. 2011;101:S238-S245. doi:10.2105/AJPH.2011.300119)
C1 [Adamkiewicz, Gary] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Landmark Ctr W, Boston, MA 02215 USA.
[Fabian, M. Patricia; Levy, Jonathan I.] Boston Univ, Dept Environm Hlth, Sch Publ Hlth, Boston, MA 02215 USA.
[Zota, Ami R.] Univ Calif San Francisco, Program Reprod Hlth & Environm, San Francisco, CA 94143 USA.
[Julien, Rhona] US EPA, Boston, MA USA.
RP Adamkiewicz, G (reprint author), Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Landmark Ctr W, 401 Pk Dr,Room 404K, Boston, MA 02215 USA.
EM gadamkie@hsph.harvard.edu
RI Levy, Jon/B-4542-2011;
OI Levy, Jon/0000-0002-1116-4006; Fabian, M. Patricia/0000-0002-1658-3349
FU National Institute of Environmental Health Sciences [R21ES017522]
FX The project was supported by the National Institute of Environmental
Health Sciences (award number R21ES017522).
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U2 42
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PY 2011
VL 101
SU 1
BP S238
EP S245
DI 10.2105/AJPH.2011.300119
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 849QU
UT WOS:000297141000035
PM 21836112
ER
PT J
AU Lobdell, DT
Jagai, JS
Rappazzo, K
Messer, LC
AF Lobdell, Danelle T.
Jagai, Jyotsna S.
Rappazzo, Kristen
Messer, Lynne C.
TI Data Sources for an Environmental Quality Index: Availability, Quality,
and Utility
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
ID SWINE FEEDING OPERATIONS; AIR-POLLUTION; HEALTH DISPARITIES; HOSPITAL
ADMISSIONS; BUILT ENVIRONMENT; MORTALITY-RATES; UNITED-STATES;
BIRTH-WEIGHT; EXPOSURE; JUSTICE
AB Objectives. An environmental quality index (EQI) for all counties in the United States is under development to explore the relationship between environmental insults and human health. The EQI is potentially useful for investigators researching health disparities to account for other concurrent environmental conditions. This article focused on the identification and assessment of data sources used in developing the EQI. Data source strengths, limitations, and utility were addressed.
Methods. Five domains were identified that contribute to environmental quality: air, water, land, built, and sociodemographic environments. An inventory of possible data sources was created. Data sources were evaluated for appropriate spatial and temporal coverage and data quality.
Results. The overall data inventory identified multiple data sources for each domain. From the inventory (187 sources, 617 records), the air, water, land, built environment, and sociodemographic domains retained 2, 9, 7, 4, and 2 data sources for inclusion in the EQI, respectively. However, differences in data quality, geographic coverage, and data availability existed between the domains.
Conclusions. The data sources identified for use in the EQI may be useful to researchers, advocates, and communities to explore specific environmental quality questions. (Am J Public Health. 2011;101:S277-S285. doi:10.2105/AJPH.2011.300184)
C1 [Lobdell, Danelle T.; Jagai, Jyotsna S.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Rappazzo, Kristen] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA.
[Messer, Lynne C.] Duke Univ, Nicholas Sch Environm, Duke Global Hlth Inst, Durham, NC 27708 USA.
[Messer, Lynne C.] Duke Univ, Nicholas Sch Environm, Childrens Environm Hlth Initiat, Durham, NC 27708 USA.
RP Lobdell, DT (reprint author), US EPA, Off Res & Dev, MD 58A, Res Triangle Pk, NC 27711 USA.
EM lobdell.danelle@epa.gov
FU Office of Research and Development (ORD); US Environmental Protection
Agency (EPA) [WCF DP26H0001, EP09D000003]; EPA Cooperative Agreement
with the University of North Carolina at Chapel Hill [CR83323601]
FX The Office of Research and Development (ORD), US Environmental
Protection Agency (EPA), partially funded the research with CSC and L.
C. Messer (Contracts WCF DP26H0001 and EP09D000003) with L. C. Messer
and under EPA Cooperative Agreement with the University of North
Carolina at Chapel Hill (CR83323601).
NR 76
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U1 1
U2 14
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PY 2011
VL 101
SU 1
BP S277
EP S285
DI 10.2105/AJPH.2011.300184
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 849QU
UT WOS:000297141000040
PM 21836111
ER
PT J
AU Nweke, OC
Garcia, L
Lee, C
Case, H
Payne-Sturges, D
Sanders, WH
Zenick, H
Grevatt, P
Dankwa-Mullan, I
AF Nweke, Onyemaechi C.
Garcia, Lisa
Lee, Charles
Case, Heather
Payne-Sturges, Devon
Sanders, William H., III
Zenick, Hal
Grevatt, Peter
Dankwa-Mullan, Irene
TI Symposium on Integrating the Science of Environmental Justice into
Decision-Making at the Environmental Protection Agency: An Overview
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Editorial Material
ID NEIGHBORHOOD PSYCHOSOCIAL HAZARDS; COMBINED MATERNAL LEAD; AMBIENT
AIR-POLLUTION; HEALTH DISPARITIES; RISK-ASSESSMENT; DIFFERENTIAL
VULNERABILITY; PRETERM BIRTH; CARDIOVASCULAR-DISEASE; COGNITIVE
FUNCTION; BALTIMORE-MEMORY
AB In March 2010, the Environmental Protection Agency (EPA) collaborated with government and nongovernmental organizations to host a groundbreaking symposium, "Strengthening Environmental Justice Research and Decision Making: A Symposium on the Science of Disproportionate Environmental Health Impacts."
The symposium provided a forum for discourse on the state of scientific knowledge about factors identified by EPA that may contribute to higher burdens of environmental exposure or risk in racial/ethnic minorities and low-income populations. Also featured were discussions on how environmental justice considerations may be integrated into EPA's analytical and decision-making frameworks and on research needs for advancing the integration of environmental justice into environmental policymaking.
We summarize key discussions and conclusions from the symposium and briefly introduce the articles in this issue. (Am J Public Health. 2011;101:S19-S26. doi:10.2105/AJPH.2011.300368)
C1 [Nweke, Onyemaechi C.; Garcia, Lisa; Lee, Charles; Case, Heather] US EPA, Off Environm Justice, Washington, DC 20460 USA.
[Payne-Sturges, Devon; Sanders, William H., III] Natl Ctr Erwimnm Res, Washington, DC USA.
[Zenick, Hal] Natl Hlth & Environm Res Lab, Washington, DC USA.
[Grevatt, Peter] US EPA, Off Childrens Hlth Protect, Washington, DC 20460 USA.
[Dankwa-Mullan, Irene] Natl Inst Minor Hlth & Hlth Dispar, Off Innovat & Coordinat, Bethesda, MD USA.
RP Nweke, OC (reprint author), US EPA, Off Environm Justice, MC 2201A,1200 Penn Ave NW, Washington, DC 20460 USA.
EM nweke.onyemaechi@epa.gov
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PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
EI 1541-0048
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PY 2011
VL 101
SU 1
BP S19
EP S26
DI 10.2105/AJPH.2011.300368
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 849QU
UT WOS:000297141000007
PM 22028456
ER
PT J
AU Nweke, OC
Lee, C
AF Nweke, Onyemaechi C.
Lee, Charles
TI Achieving Environmental Justice: Perspectives on the Path Forward
Through Collective Action to Eliminate Health Disparities
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Editorial Material
C1 [Nweke, Onyemaechi C.] US EPA, Off Environm Justice, Off Enforcement & Compliance, Washington, DC 20460 USA.
RP Nweke, OC (reprint author), US EPA, Off Environm Justice, Off Enforcement & Compliance, MC 2201A,1200 Penn Ave,NW, Washington, DC 20460 USA.
EM nweke.onyemaechi@epa.gov
NR 9
TC 1
Z9 1
U1 0
U2 8
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PY 2011
VL 101
SU 1
BP S6
EP S8
DI 10.2105/AJPH.2011.300377
PG 3
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 849QU
UT WOS:000297141000002
PM 22028455
ER
PT J
AU Payne-Sturges, D
AF Payne-Sturges, Devon
TI Humanizing Science at the US Environmental Protection Agency
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Editorial Material
ID HEALTH DISPARITIES; INEQUALITY
C1 US EPA, Off Res & Dev, Natl Ctr Environm Res, Washington, DC 20460 USA.
RP Payne-Sturges, D (reprint author), US EPA, Off Res & Dev, Natl Ctr Environm Res, 1200 Penn Ave NW,Mail Code 8723P, Washington, DC 20460 USA.
EM payne-sturges.devon@epa.gov
NR 10
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U1 1
U2 5
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PY 2011
VL 101
SU 1
BP S8
EP S12
DI 10.2105/AJPH.2011.300369
PG 5
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 849QU
UT WOS:000297141000003
PM 22028453
ER
PT J
AU Zartarian, VG
Schultz, BD
Barzyk, TM
Smuts, M
Hammond, DM
Medina-Vera, M
Geller, AM
AF Zartarian, Valerie G.
Schultz, Bradley D.
Barzyk, Timothy M.
Smuts, MaryBeth
Hammond, Davyda M.
Medina-Vera, Myriam
Geller, Andrew M.
TI The Environmental Protection Agency's Community-Focused Exposure and
Risk Screening Tool (C-FERST) and Its Potential Use for Environmental
Justice Efforts
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
ID HEALTH; HOMES
AB Objectives. Our primary objective was to provide higher quality, more accessible science to address challenges of characterizing local-scale exposures and risks for enhanced community-based assessments and environmental decision-making.
Methods. After identifying community needs, priority environmental issues, and current tools, we designed and populated the Community-Focused Exposure and Risk Screening Tool (C-FEAST) in collaboration with stakeholders, following a set of defined principles, and considered it in the context of environmental justice.
Results. C-FEAST is a geographic information system and resource access Web tool under development for supporting multimedia community assessments. Community-level exposure and risk research is being conducted to address specific local issues through case studies.
Conclusions. C-FERST can be applied to support environmental justice efforts. It incorporates research to develop community-level data and modeled estimates for priority environmental issues, and other relevant information identified by communities. Initial case studies are under way to refine and test the tool to expand its applicability and transferability. Opportunities exist for scientists to address the many research needs in characterizing local cumulative exposures and risks and for community partners to apply and refine C-FERST. (Am J Public Health. 2011;101:S286-S294. doi:10.2105/AJPH.2010.300087)
C1 [Zartarian, Valerie G.; Schultz, Bradley D.; Barzyk, Timothy M.; Hammond, Davyda M.; Medina-Vera, Myriam; Geller, Andrew M.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Smuts, MaryBeth] EPAs New England Reg 1 Off, Boston, MA USA.
RP Zartarian, VG (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, 109 TW Alexander Dr,E205-02, Res Triangle Pk, NC 27711 USA.
EM zartarian.valerie@epa.gov
NR 28
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U1 0
U2 13
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PY 2011
VL 101
SU 1
BP S286
EP S294
DI 10.2105/AJPH.2010.300087
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 849QU
UT WOS:000297141000041
PM 22021316
ER
PT J
AU de la Cruz, AA
Antoniou, MG
Hiskia, A
Pelaez, M
Song, WH
O'Shea, KE
He, XX
Dionysiou, DD
AF de la Cruz, Armah A.
Antoniou, Maria G.
Hiskia, Anastasia
Pelaez, Miguel
Song, Weihua
O'Shea, Kevin E.
He, Xuexiang
Dionysiou, Dionysios D.
TI Can We Effectively Degrade Microcystins? - Implications on Human Health
SO ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
LA English
DT Article
DE Biodegradation; degradation; hydroxyl radicals; photolysis; ozone;
sonolysis; sulfate radicals
ID CYANOBACTERIAL HEPATOTOXIN MICROCYSTIN; ULTRASONICALLY INDUCED
DEGRADATION; PRIMARY LIVER-CANCER; BLUE-GREEN-ALGAE; WATER-TREATMENT;
BACTERIAL-DEGRADATION; PHOTOCATALYTIC DEGRADATION; BLOOM CONTROL; SAND
FILTER; GROWTH-INHIBITION
AB Microcystins are cyclic heptapeptide toxins produced by a number of genera of cyanobacteria. They are ubiquitous in bodies of water worldwide and pose significant hazard to human, plant, and animal health. Microcystins are primarily hepatotoxins known to inhibit serine-threonine phosphatases leading to the disruption of cascade of events important in the regulation and control of cellular processes. Covalent binding of microcystins with phosphatases is thought to be responsible for the cytotoxic and genotoxic effects of microcystins. In addition, microcystins can trigger oxidative stress in cells resulting in necrosis or apoptosis. Their cyclic structure and novel amino acids enhance their stability and persistence in the environment. Humans are primarily exposed to microcystins via drinking water consumption and accidental ingestion of recreational water. Recreational exposure by skin contact or inhalation to microcystins is now recognized to cause a wide range of acute illnesses which can be life-threatening.
Microcystins are primarily degraded by microorganisms in the environment, while sunlight can cause the isomerization of the double bonds and hydroxylation in the presence of pigments. Attempts to utilize these organisms in sand and membrane filters to treat water contaminated with microcystins showed complete removal and detoxification. Conventional water treatment processes may not fully eliminate microcystins when there are high levels of organic compounds especially during harmful bloom events. Combination of conventional and advanced oxidation technologies can potentially remove 100% of microcystins in water even in turbid conditions. This review covers selected treatment technologies to degrade microcystins in water.
C1 [Pelaez, Miguel; He, Xuexiang; Dionysiou, Dionysios D.] Univ Cincinnati, Environm Engn & Sci Program, Cincinnati, OH 45221 USA.
[de la Cruz, Armah A.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
[Antoniou, Maria G.] Tech Univ Denmark, Dept Environm Engn, DK-2800 Lyngby, Denmark.
[Hiskia, Anastasia] Natl Ctr Sci Res Demokritos, Lab Catalyt Photocatalyt Proc Solar Energy Enviro, Agia Paraskevi Athens 15310, Greece.
[Song, Weihua; O'Shea, Kevin E.] Florida Int Univ, Dept Chem & Biochem, Miami, FL 33183 USA.
RP Dionysiou, DD (reprint author), Univ Cincinnati, Environm Engn & Sci Program, Cincinnati, OH 45221 USA.
EM dionysios.d.dionysiou@uc.edu
RI Song, Weihua/B-6931-2011; He, Xuexiang/D-7564-2017;
OI Song, Weihua/0000-0001-7633-7919; Antoniou, Maria G./0000-0003-0738-6068
FU U.S. Environmental Protection Agency [R833223]; European Commission
[227017]; Research DG of the European Commission; US National Science
Foundation [BES-0448117]
FX D. D. Dionysiou and K. E. O'Shea acknowledge support for this work from
the U.S. Environmental Protection Agency (R833223). D. D. Dionysiou and
A. Hiskia acknowledge support from the European Commission (Clean Water
- Grant Agreement number 227017). Clean Water is a Collaborative Project
co-funded by the Research DG of the European Commission within the joint
RTD activities of the Environment and NMP Thematic Priorities/FP7. D.
Dionysiou also acknowledges support on his work on sulfate radicals from
the US National Science Foundation through a CAREER award (BES-0448117).
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PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
EMIRATES
SN 1871-5206
J9 ANTI-CANCER AGENT ME
JI Anti-Cancer Agents Med. Chem.
PD JAN
PY 2011
VL 11
IS 1
BP 19
EP 37
PG 19
WC Oncology; Chemistry, Medicinal
SC Oncology; Pharmacology & Pharmacy
GA 743BW
UT WOS:000288991900003
PM 21269255
ER
PT J
AU Kelly, JR
AF Kelly, John R.
TI Ecology of Lake Superior: Preface and Prospectus
SO AQUATIC ECOSYSTEM HEALTH & MANAGEMENT
LA English
DT Editorial Material
C1 US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Lab, Off Res & Dev, Duluth, MN 55804 USA.
RP Kelly, JR (reprint author), US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Lab, Off Res & Dev, Duluth, MN 55804 USA.
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PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1463-4988
J9 AQUAT ECOSYST HEALTH
JI Aquat. Ecosyst. Health Manag.
PY 2011
VL 14
IS 4
BP 329
EP 331
DI 10.1080/14634988.2011.633779
PG 3
WC Ecology; Environmental Sciences; Marine & Freshwater Biology; Water
Resources
SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water
Resources
GA 866BZ
UT WOS:000298355900002
ER
PT J
AU Kelly, JR
Yurista, PM
Miller, SE
Cotter, AC
Corry, TC
Scharold, JV
Sierszen, ME
Isaac, EJ
Stockwell, JD
AF Kelly, John R.
Yurista, Peder M.
Miller, Samuel E.
Cotter, Anne C.
Corry, Timothy C.
Scharold, Jill V.
Sierszen, Michael E.
Isaac, Edmund J.
Stockwell, Jason D.
TI Challenges to Lake Superior's condition, assessment, and management: A
few observations across a generation of change
SO AQUATIC ECOSYSTEM HEALTH & MANAGEMENT
LA English
DT Article
DE water quality; biology; generational trends; environmental assessment
ID GREAT-LAKES; BENTHIC INVERTEBRATES; ABUNDANCE; DIPOREIA; PATTERNS;
FISHES; TRENDS; HARBOR
AB Selected comparisons of water quality and biological properties in lakewide samplings of the early 1970s and 2005-2006 illustrate a range of ecological changes within Lake Superior over the last three decades. Comparisons depict warmed surface layers, and increased chloride and nitrate concentrations-confirming trends described in recent literature. Our comparisons also depict some spatial dimensions of change, showing vertical and horizontal patterns throughout the lake as a function of depth and from shallow to deepest waters. The selected physico-chemical examples speak to different scales of source drivers for change (from local, to basinwide, and even global) and highlight a lake in which some fundamental properties have been influenced in a short period relative to its long flushing time (similar to 170 years). One legacy of the past 30 years of study seems clear: the notion that Lake Superior, due to its vastness, is resistant to environmental forcing and very slow to change, has been modified. We use two important biological components to evaluate change and also to contrast biological distributions, highlighting that some fundamental aspects of food webs vary with depth. Reflecting on these observations, we offer a perspective on how well we keep track of the condition and functioning of the lake, and how we might improve assessments to more actively inform management. Without more frequent biological sampling across all depth zones of the lake, there will continue to be limited ability to assess the nature and causes of ecological change, even when some changes are detected. Knowing that physico-chemical changes can occur relatively quickly (within decades), that the mechanisms for change can be expressed over different spatial dimensions of the lake, and that biology is distributed heterogeneously over these spatial dimensions, we argue the need to increase the degree (the spatial comprehensiveness, frequency, and integration of components) to which the lake is assessed.
C1 [Kelly, John R.; Yurista, Peder M.; Miller, Samuel E.; Cotter, Anne C.; Corry, Timothy C.; Scharold, Jill V.; Sierszen, Michael E.] US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Duluth, MN 55804 USA.
[Isaac, Edmund J.] Univ Minnesota, Duluth Dept Biol, Duluth, MN 55812 USA.
[Stockwell, Jason D.] Gulf Maine Res Inst, Portland, ME 04101 USA.
[Stockwell, Jason D.] Univ Vermont, Rubenstein Ecosyst Sci Lab, Burlington, VT 05401 USA.
RP Kelly, JR (reprint author), US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, 6201 Congdon Blvd, Duluth, MN 55804 USA.
EM kelly.johnr@epa.gov
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PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1463-4988
J9 AQUAT ECOSYST HEALTH
JI Aquat. Ecosyst. Health Manag.
PY 2011
VL 14
IS 4
BP 332
EP 344
DI 10.1080/14634988.2011.626753
PG 13
WC Ecology; Environmental Sciences; Marine & Freshwater Biology; Water
Resources
SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water
Resources
GA 866BZ
UT WOS:000298355900003
ER
PT J
AU Yurista, P
Kelly, JR
Miller, SE
AF Yurista, Peder
Kelly, John R.
Miller, Samuel E.
TI Lake Superior: Nearshore variability and a landscape driver concept
SO AQUATIC ECOSYSTEM HEALTH & MANAGEMENT
LA English
DT Article
DE monitoring; spatial scales; electronic sensors; optical plankton counter
ID OPTICAL PLANKTON COUNTER; GREAT-LAKES; WATER-QUALITY; COASTAL WETLANDS;
ZOOPLANKTON; CALIBRATION; TRANSPORT; DESIGN; TOOL; TOR
AB Spatial variation is well known to exist in water quality parameters of the Great Lakes nearshore; however, strong patterns for extended reaches also have been observed and found to be robust across seasonal time frames. Less is known about robustness of inter-annual variation within parameters for water quality in the nearshore. We have conducted high-resolution surveys with towed electronic instrumentation in nearshore areas of Lake Superior and have combined several seasons (2001-2005) of measurements from multiple research efforts to investigate how spatial variation compares across years. The combined survey tows ranged across approximately 1200 km of Lake Superior's south shore. In addition to the survey tracks, we also sampled fixed stations to collect calibration data and other parameters not observed by the in situ electronic sensors. The towed sensor data provided information on the spatial and temporal variability of water quality parameters along the nearshore. We found a consistent spatial pattern over time along the south shore of Lake Superior. Nearshore water quality parameters were analyzed with respect to landscape characteristics of the adjacent watersheds (US only) using multivariate stepwise regressions and found to correlate to landscape characterization. The stressor categories of landscape character that best described the nearshore parameters were agriculture-chemical usage and land-cover attributes. Peak nearshore values corresponded with landscape position that had the most altered landuse character (e. g. Duluth/Superior region). The landscape character appears to drive and maintain the spatial pattern in nearshore water quality parameters.
C1 [Yurista, Peder; Kelly, John R.; Miller, Samuel E.] US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Duluth, MN 55804 USA.
RP Yurista, P (reprint author), US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, 6201 Congdon Blvd, Duluth, MN 55804 USA.
EM yurista.peder@epa.gov
FU US Environmental Protection Agency
FX This research was funded wholly by the US Environmental Protection
Agency. The views expressed in this article are those of the authors and
do not necessarily reflect the views or policies of the US Environmental
Protection Agency.
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SN 1463-4988
J9 AQUAT ECOSYST HEALTH
JI Aquat. Ecosyst. Health Manag.
PY 2011
VL 14
IS 4
BP 345
EP 355
DI 10.1080/14634988.2011.624942
PG 11
WC Ecology; Environmental Sciences; Marine & Freshwater Biology; Water
Resources
SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water
Resources
GA 866BZ
UT WOS:000298355900004
ER
PT J
AU Niemi, GJ
Reavie, ED
Peterson, GS
Kelly, JR
Johnston, CA
Johnson, LB
Howe, RW
Host, GE
Hollenhorst, TP
Danz, NP
Ciborowski, JJH
Brown, TN
Brady, VJ
Axler, RP
AF Niemi, Gerald J.
Reavie, Euan D.
Peterson, Gregory S.
Kelly, John R.
Johnston, Carol A.
Johnson, Lucinda B.
Howe, Robert W.
Host, George E.
Hollenhorst, Tom P.
Danz, Nicholas P.
Ciborowski, Jan J. H.
Brown, Terry N.
Brady, Valerie J.
Axler, Richard P.
TI An integrated approach to assessing multiple stressors for coastal Lake
Superior
SO AQUATIC ECOSYSTEM HEALTH & MANAGEMENT
LA English
DT Article
DE birds; diatoms; fish; indicators; macroinvertebrates; plants
ID LAURENTIAN GREAT-LAKES; WATER-QUALITY; WETLAND INDICATORS; ENVIRONMENTAL
INDICATORS; ECOLOGICAL INDICATORS; ANTHROPOGENIC STRESS; INDEX;
ECOSYSTEMS; RESPONSES; GRADIENT
AB Biological indicators can be used both to estimate ecological condition and to suggest plausible causes of ecosystem degradation across the U.S. Great Lakes coastal region. Here we use data on breeding bird, diatom, fish, invertebrate, and wetland plant communities to develop robust indicators of ecological condition of the U.S. Lake Superior coastal zone. Sites were selected as part of a larger, stratified random design for the entire U.S. Great Lakes coastal region, covering gradients of anthropogenic stress defined by over 200 stressor variables (e.g. agriculture, altered land cover, human populations, and point source pollution). A total of 89 locations in Lake Superior were sampled between 2001 and 2004 including 31 sites for stable isotope analysis of benthic macroinvertebrates, 62 sites for birds, 35 for diatoms, 32 for fish and macroinvertebrates, and 26 for wetland vegetation. A relationship between watershed disturbance metrics and (15)N levels in coastal macroinvertebrates confirmed that watershed-based stressor gradients are expressed across Lake Superior's coastal ecosystems, increasing confidence in ascribing causes of biological responses to some landscape activities. Several landscape metrics in particular-agriculture, urbanization, human population density, and road density-strongly influenced the responses of indicator species assemblages. Conditions were generally good in Lake Superior, but in some areas watershed stressors produced degraded conditions that were similar to those in the southern and eastern U.S. Great Lakes. The following indicators were developed based on biotic responses to stress in Lake Superior in the context of all the Great Lakes: (1) an index of ecological condition for breeding bird communities, (2) diatom-based nutrient and solids indicators, (3) fish and macroinvertebrate indicators for coastal wetlands, and (4) a non-metric multidimensional scaling for wetland plants corresponding to a cumulative stress index. These biotic measures serve as useful indicators of the ecological condition of the Lake Superior coast; collectively, they provide a baseline assessment of selected biological conditions for the U.S. Lake Superior coastal region and prescribe a means to detect change over time.
C1 [Niemi, Gerald J.; Johnson, Lucinda B.; Host, George E.; Hollenhorst, Tom P.; Brown, Terry N.; Brady, Valerie J.; Axler, Richard P.] Univ Minnesota, Nat Resources Res Inst, Ctr Water & Environm, Duluth, MN 55811 USA.
[Reavie, Euan D.] Univ Minnesota Duluth, Nat Resources Res Inst, Ctr Water & Environm, Ely Field Stn, Ely, MN 55731 USA.
[Peterson, Gregory S.; Kelly, John R.; Hollenhorst, Tom P.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA.
[Johnston, Carol A.] S Dakota State Univ, Dept Biol & Microbiol, Brookings, SD 57007 USA.
[Howe, Robert W.] Univ Wisconsin, Cofrin Ctr Biodivers, Dept Nat & Appl Sci, Green Bay, WI 54311 USA.
[Danz, Nicholas P.] Univ Wisconsin Superior, Dept Nat Sci, Superior, WI 54880 USA.
[Ciborowski, Jan J. H.] Univ Windsor, Dept Biol Sci, Windsor, ON N9B 3P4, Canada.
RP Niemi, GJ (reprint author), Univ Minnesota, Nat Resources Res Inst, Ctr Water & Environm, 5013 Miller Trunk Highway, Duluth, MN 55811 USA.
EM gniemi@d.umn.edu
RI feng, yongzhong/F-5090-2012;
OI feng, yongzhong/0000-0002-5202-4368; Reavie, Euan/0000-0001-8871-5809;
Johnston, Carol/0000-0002-9663-5048
FU U.S. EPA [EPA/R82867501, EPA/R-82877701]
FX J. Hanowski was instrumental in gathering, compiling, and analyzing the
breeding bird data. Diatom identification and enumeration results were
supported by N. Andresen, G. Sgro, M. Ferguson, and A. Kireta; and
diatom taxonomic support was provided by J. Kingston, E. Stoermer, and
J. Johansen. D. Breneman, J. Schuldt, J. D. Holland, J. P. Gathman, R.
Hell, A. Ly, J. Baillargeon, and J. Wiklund provided assistance with
fish and macroinvertebrate data and sampling. M. Aho, A. Boers, K.
Bailey Boomer, M. Bourdaghs, K. Cappillino, R. Clark, S. Cronk, A.
Freeman, C. Frieswyk, D. James, C. Johnson, L. Ladwig, A. Marsh, M.
Tittler, L. Vaccaro, and C. Williams collected vegetation field data. We
thank D. McKenney and P. Papadopol of the Great Lakes Forestry Centre
for providing the GDD data. Water quality sampling and analysis were
supported by J. Henneck, E. Ruzycki, J. Reed, and J. Ameel. R. Regal
provided statistical advice. Although this research has been funded
wholly or in part by the U.S. EPA through cooperative agreement
EPA/R82867501 to the Great Lakes Environmental Indicators project, and
through grant EPA/R-82877701 to L. Johnson, it has not been subjected to
the agency's required peer and policy review and therefore does not
necessarily reflect the views of the agency and no official endorsement
should be inferred. This is contribution number 521 from the Center for
Water and the Environment, Natural Resources Research Institute,
University of Minnesota Duluth.
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SN 1463-4988
J9 AQUAT ECOSYST HEALTH
JI Aquat. Ecosyst. Health Manag.
PY 2011
VL 14
IS 4
BP 356
EP 375
DI 10.1080/14634988.2011.628254
PG 20
WC Ecology; Environmental Sciences; Marine & Freshwater Biology; Water
Resources
SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water
Resources
GA 866BZ
UT WOS:000298355900005
ER
PT J
AU Host, GE
Brown, TN
Hollenhorst, TP
Johnson, LB
Ciborowski, JJH
AF Host, George E.
Brown, Terry N.
Hollenhorst, Tom P.
Johnson, Lucinda B.
Ciborowski, Jan J. H.
TI High-resolution assessment and visualization of environmental stressors
in the Lake Superior basin
SO AQUATIC ECOSYSTEM HEALTH & MANAGEMENT
LA English
DT Article
DE anthropogenic stressors; Great Lakes; environmental indicators;
watersheds; ArcHydro
ID GREAT-LAKES; WETLAND INDICATORS; COASTAL ECOSYSTEMS
AB Quantifying gradients of anthropogenic stress can inform the development of sample designs, provide an important covariate in modeling relationships of response variables, identify reference and highly-disturbed sites, and provide a baseline and guidance to restoration and remediation efforts. We describe development of SumRel, a composite index of anthropogenic stress, for the U.S. and Canadian Lake Superior basin. Key elements of the project include development of high-resolution watersheds throughout the basin, summarization of the major point and non-point stressors within these watersheds, and creation of tools for scaling watersheds and stressor summaries. SumRel was calculated at two spatial scales: for high resolution subcatchments within the Lake Superior basin (mean watershed area = 93 ha) and for coastal watersheds of Lake Superior. An assessment of subcatchments within Minnesota's St. Louis River watershed showed a correlation between the degree of disturbance, as indicated by SumRel, and impaired water quality, as evidenced by in-stream conductivity. These data and tools allow identification and visualization of reference and highly-disturbed sites at multiple spatial scales, providing decision support for individual agency and binational monitoring, assessment and restoration initiatives across the Lake Superior basin.
C1 [Host, George E.; Brown, Terry N.; Hollenhorst, Tom P.; Johnson, Lucinda B.] Univ Minnesota, Nat Resources Res Inst, Ctr Water & Environm, Duluth, MN 55811 USA.
[Hollenhorst, Tom P.] US EPA, Off Res & Dev, Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA.
[Ciborowski, Jan J. H.] Univ Windsor, Dept Biol Sci, Windsor, ON N9B 3P4, Canada.
RP Host, GE (reprint author), Univ Minnesota, Nat Resources Res Inst, Ctr Water & Environm, 5013 Miller Trunk Highway, Duluth, MN 55811 USA.
EM ghost@d.umn.edu
FU U.S. EPA Great Lakes National Program Office [GL00E28801-0]; U.S. EPA;
Minnesota Pollution Control Agency; National Fish and Wildlife
Foundation; Environment Canada
FX Ms. Jane Reed created the website design for 'Explore Lake Superior,'
and Mr. Gerald Sjerven served as website administrator. This work was
funded in part by a grant from the U.S. EPA Great Lakes National Program
Office, Grant number: GL00E28801-0. Although this research has been
funded wholly or in part by the U.S. EPA, it has not been subjected to
the agency's required peer and policy review and therefore does not
necessarily reflect the views of the agency and no official endorsement
should be inferred. Dr. Richard Axler generously shared water quality
data collected in the St. Louis River watershed; funding for this
analysis was provided by the Minnesota Pollution Control Agency. The
integration of the U.S. and Canadian land use classifications was funded
by grants from the National Fish and Wildlife Foundation, and
Environment Canada through the Lake Erie Lakewide Area Management Plan
to the University of Windsor and the Lake Erie Millennium Network. This
is contribution number 517 from the Center for Water and the
Environment, Natural Resources Research Institute, University of
Minnesota-Duluth.
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SN 1463-4988
J9 AQUAT ECOSYST HEALTH
JI Aquat. Ecosyst. Health Manag.
PY 2011
VL 14
IS 4
BP 376
EP 385
DI 10.1080/14634988.2011.625340
PG 10
WC Ecology; Environmental Sciences; Marine & Freshwater Biology; Water
Resources
SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water
Resources
GA 866BZ
UT WOS:000298355900006
ER
PT J
AU Hoffman, JC
Cotter, AM
Peterson, GS
Corry, TD
Kelly, JR
AF Hoffman, Joel C.
Cotter, Anne M.
Peterson, Gregory S.
Corry, Timothy D.
Kelly, John R.
TI Rapid stable isotope turnover of larval fish in a Lake Superior coastal
wetland: Implications for diet and life history studies
SO AQUATIC ECOSYSTEM HEALTH & MANAGEMENT
LA English
DT Article
DE delta(13)C; delta(15)N; foodweb; St. Louis River
ID GREAT-LAKES; FOOD-WEB; NITROGEN; CARBON; FRACTIONATION; SETTLEMENT;
ECOSYSTEM; VIRGINIA; TISSUES; RATIOS
AB Trophic linkages of larval fish in Lake Superior coastal habitats can be identified using naturally occurring differences in the stable isotope ratios of nitrogen ((15)N: (14)N, delta(15)N) and carbon ((13)C: (12)C, delta(13)C). We measured (13)C and (15)N values in common fish larvae weekly during spring run-off (late-April to mid-July) in the hydrologically complex drowned river mouth of the St. Louis River, the second largest tributary to Lake Superior. For all species, delta(13)C was increasingly negative with increasing weight as the fish developed from the yolk-sac stage, during which they possess a maternally-derived isotopic signature, to an exogenously feeding larvae. Trends in delta(15)N with increasing weight varied among species; an increase, decrease, and no change in delta(15)N were observed. A weight-based stable isotope turnover function modeled well the observed changes in delta(13)C and delta(15)N. In general, fish obtained a constant signature after a 10-fold gain in body mass, implying their tissue was at isotopic equilibrium with their diet. Difference between yolk-sac and larvae delta(13)C and delta(15)N revealed distinct patterns in larval origin and settlement. Based on the species analyzed, we identify two specific Lake Superior coastal wetland-dependent fish early life histories that incorporate habitat use, movement, and trophic dynamics. This study thus provides a methodological approach that can potentially help resolve interactions between watershed character, coastal productivity, and Lake Superior that are of significance to the lake's fisheries.
C1 [Hoffman, Joel C.; Cotter, Anne M.; Peterson, Gregory S.; Corry, Timothy D.; Kelly, John R.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN USA.
RP Hoffman, JC (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN USA.
EM hoffman.joel@epa.gov
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SN 1463-4988
J9 AQUAT ECOSYST HEALTH
JI Aquat. Ecosyst. Health Manag.
PY 2011
VL 14
IS 4
BP 403
EP 413
DI 10.1080/14634988.2011.628212
PG 11
WC Ecology; Environmental Sciences; Marine & Freshwater Biology; Water
Resources
SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water
Resources
GA 866BZ
UT WOS:000298355900009
ER
PT J
AU Knuth, ML
Kelly, JR
AF Knuth, Michael L.
Kelly, John R.
TI Denitrification rates in a Lake Superior coastal wetland
SO AQUATIC ECOSYSTEM HEALTH & MANAGEMENT
LA English
DT Article
DE MIMS; nitrate; sediment respiration rate
ID MASSACHUSETTS BAY; BOSTON HARBOR; GREAT-LAKES; NITROGEN; SEDIMENTS;
ECOSYSTEMS; RETENTION; HYDROLOGY; DYNAMICS
AB The amount of excess fixed nitrogen removed from the freshwater aquatic nitrogen cycle, particularly by freshwater wetlands, through denitrification (DNF) is largely unknown. Typically, DNF rates increase within sediments that have higher organic content and a source of sufficient NO(3)(-), in this context we measured DNF in organic-rich sediments of Lost Creek wetland on the south shore of Lake Superior, where NO(3)(-) concentrations have increased dramatically over the last century. The concentrations of N(2), O(2), and Ar were determined on intact water-sediment cores. Denitrification and respiration rates were determined using membrane inlet mass spectrometry and N(2):Ar and O(2):Ar ratios. Nitrogen flux rates measured in August 2000 and 2001 using overlying ambient wetland water, Lake Superior water, and nitrate augmented wetland water ranged from <10 to 78 mu mol N m(-2) h(-1). These rates are low compared to those published for a variety of wetland and aquatic ecosystems. Nonetheless these are the first DNF measurements we know of to assess natural rates in the Lake Superior Basin and they help quantify a missing piece of wetland and lake nitrogen transformations.
C1 [Knuth, Michael L.; Kelly, John R.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA.
RP Knuth, ML (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA.
EM knuth.michael@epa.gov
FU U.S. Environmental Protection Agency
FX We thank Todd Kana and staff at Horn Point Laboratory, University of
Maryland, for advice, instruction, and analysis of core water samples
for dissolved gasses; Anne Cotter for the nutrient analysis of core
water and wetland samples; and Corlis West for the sediment
characterization. Thanks to Brian Hill and MaryAnn Starus for reviewing
and commenting on this manuscript. This work was wholly funded by the
U.S. Environmental Protection Agency and has been approved for
publication after review by EPA's National Health and Environmental
Effects Research laboratory. The contents do not necessarily reflect the
views of the agency, nor does mention of commercial products constitute
endorsement or recommendation for use.
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J9 AQUAT ECOSYST HEALTH
JI Aquat. Ecosyst. Health Manag.
PY 2011
VL 14
IS 4
BP 414
EP 421
DI 10.1080/14634988.2011.624488
PG 8
WC Ecology; Environmental Sciences; Marine & Freshwater Biology; Water
Resources
SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water
Resources
GA 866BZ
UT WOS:000298355900010
ER
PT J
AU Hollenhorst, TP
Johnson, LB
Ciborowski, J
AF Hollenhorst, T. P.
Johnson, L. B.
Ciborowski, J.
TI Monitoring land cover change in the Lake Superior basin
SO AQUATIC ECOSYSTEM HEALTH & MANAGEMENT
LA English
DT Article
DE Great Lakes; land use change; National Land Cover Data; Ontario
Provincial Land Cover; Binational Land Cover
ID FOREST FRAGMENTATION; LANDSCAPE FRAGMENTATION; INDICATOR; STATES; BIRDS
AB Consistent, repeatable and broadly applicable land use, land cover data is needed across the Lake Superior basin to facilitate ecosystem condition assessment and trend analysis. Such a data set collected regularly through time could inform and focus field monitoring efforts, and help prioritize restoration and mitigation efforts. Unfortunately, few data sets exist that are bi-nationally consistent in time, classification method, or resolution. To this end, we integrated land cover data across both the Canadian (Ontario Provincial Land Cover data) and US portions (National Land Cover Data) of the Lake Superior basin for two time steps (approximately 1992 and 2001) roughly one decade apart. After harmonizing landcover classes across the two datasets we compared the explicit amount and relative amount (total hectares and proportion of each area as percents) for each of the common land cover classes that occurred across the two time steps for the entire Lake Superior basin, for the U.S. portion of the Lake Superior basin only, and for the Canadian portion of the Lake Superior basin only. We also compared land cover change for the entire basin within a 1 km and a 10 km buffer of the Great Lakes shoreline. We then summarized and compared these land cover types for each time period across a common set of watersheds derived from elevation data (Hollenhorst et al., 2007) for the entire Lake Superior basin. This allowed us to identify and quantify the types of change occurring generally across the entire basin, more specifically across both the U. S. and Canadian portions of the basin, and more explicitly for near coastal areas and watersheds across the entire basin. Noteworthy changes were detected across the basin, particularly an increase in mixed forest types and a corresponding decrease in coniferous forest types.
C1 [Hollenhorst, T. P.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA.
[Johnson, L. B.] Univ Minnesota, Nat Resources Res Inst, Duluth, MN 55811 USA.
[Ciborowski, J.] Univ Windsor, Dept Biol Sci, Windsor, ON N9B 3P4, Canada.
RP Hollenhorst, TP (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA.
EM hollenhorst.tom@epa.gov
FU U.S. Environmental Protection Agency [R828675-00]
FX This research has been supported in part by the U.S. Environmental
Protection Agency's Science to Achieve Results (STAR) Estuarine and
Great Lakes (EaGLe) program through funding to Great Lakes Environmental
Indicators (GLEI), U. S. EPA Agreement R828675-00. We would like to
thank Dr. Pete Wolter and his co-authors who made the U.S. NLCD data
available. We would also like to thank Mike Robertson of Land
Information Ontario who helped us with the Ontario data. Dr. Terry
Brown, of the Natural Resources Research Institute, University of
Minnesota Duluth, was very helpful in considering the approach and the
results of this effort and we very much appreciate his assistance. Three
anonymous reviewers also helped to greatly improve the quality of this
manuscript. This document has been reviewed in accordance with U.S.
Environmental Protection Agency policy and approved for publication.
Mention of trade names or commercial products does not constitute
endorsement or recommendation for use.
NR 17
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U1 2
U2 10
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1463-4988
J9 AQUAT ECOSYST HEALTH
JI Aquat. Ecosyst. Health Manag.
PY 2011
VL 14
IS 4
BP 433
EP 442
DI 10.1080/14634988.2011.628242
PG 10
WC Ecology; Environmental Sciences; Marine & Freshwater Biology; Water
Resources
SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water
Resources
GA 866BZ
UT WOS:000298355900012
ER
PT J
AU Trebitz, AS
Brazner, JC
Tanner, DK
Meyer, R
AF Trebitz, Anett S.
Brazner, John C.
Tanner, Danny K.
Meyer, Roger
TI Interacting watershed size and landcover influences on habitat and biota
of Lake Superior coastal wetlands
SO AQUATIC ECOSYSTEM HEALTH & MANAGEMENT
LA English
DT Article
DE Great Lakes; watershed landuse; hydrology; water quality; zoobenthos;
fish; turtles
ID LAURENTIAN GREAT-LAKES; LAND-USE; DISTURBANCE GRADIENT; STREAM
ECOSYSTEMS; FISH ASSEMBLAGES; QUALITY; BASIN; INDICATORS; PATTERNS;
MARSHES
AB Coastal wetlands are important contributors to large-lake productivity and biodiversity and mediators of lake - watershed interactions. This study explores whether the size of the watershed in which coastal wetlands are embedded (a measure of strength of connection to the terrestrial landscape) influences their background condition and response to anthropogenic landuse. Water quality, substrate, vegetation structure, and composition of zoobenthos, turtles, crayfish, and fish were characterized in 32 Lake Superior coastal wetlands in the summers of 2000-2001, and related to watershed size categories via ANOVA and to watershed development (percent agricultural and urban landuse) via linear regression. Lake Superior coastal wetlands had relatively low levels of watershed development - apparently not enough to significantly alter fish composition. However, watershed development was associated with significant changes in substrate, turbidity, plant structure, and zoobenthos, and in most cases these effects were stronger in wetlands having big rather than small watersheds. An alternate classification contrasting exposure to versus protection from river influences was not effective at resolving responses to watershed development. Watershed size had little effect on background conditions in minimally disturbed wetlands, although turtles were more abundant in large-watershed wetlands. The role of watershed size in mediating responses to landuse merits further study, but our findings suggest that receiving inflows from bigger watersheds affects coastal wetlands primarily by amplifying transmission of disturbance rather than via direct impacts of flow.
C1 [Trebitz, Anett S.; Brazner, John C.; Tanner, Danny K.; Meyer, Roger] US EPA, Natl Hlth & Environm Effects Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA.
[Brazner, John C.] Nova Scotia Environm, Halifax, NS B3J 2P8, Canada.
RP Trebitz, AS (reprint author), US EPA, Natl Hlth & Environm Effects Lab, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA.
EM trebitz.anett@epa.gov
FU U.S. Environmental Protection Agency
FX We thank Matthew Starry for additional GIS processing, and Michael
Sierszen, John Morrice, and Jack Kelly for discussions and feedback on
various aspects of this work. Comments from two anonymous reviewers
helped to improve the manuscript. Although this work was fully funded by
the U.S. Environmental Protection Agency, the views expressed are those
of the authors and do not necessarily reflect the views or policies of
the Agency.
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U1 5
U2 31
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1463-4988
J9 AQUAT ECOSYST HEALTH
JI Aquat. Ecosyst. Health Manag.
PY 2011
VL 14
IS 4
BP 443
EP 455
DI 10.1080/14634988.2011.635901
PG 13
WC Ecology; Environmental Sciences; Marine & Freshwater Biology; Water
Resources
SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water
Resources
GA 866BZ
UT WOS:000298355900013
ER
PT J
AU Haring, HJ
Blocksom, KA
Smith, ME
Angradi, T
Wratschko, MC
Armstrong, B
Bolgrien, D
Lazorchak, JM
AF Haring, Herman J.
Blocksom, Karen A.
Smith, Mark E.
Angradi, Theodore
Wratschko, Melissa C.
Armstrong, Brandon
Bolgrien, David
Lazorchak, James M.
TI Sediment Toxicity in Mid-Continent Great Rivers (USA)
SO ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
LA English
DT Article
ID MISSISSIPPI RIVER; MARINE-SEDIMENTS; QUALITY TRIAD; AMPHIPOD; PREDICT;
WATER
AB As part of the Environmental Monitoring and Assessment Program for Great River Ecosystems (EMAP-GRE), sediment samples were collected from 447 randomly selected littoral sites along the main channels of the Ohio, Missouri, and Upper Mississippi Rivers between 2004 and 2006. Toxicity of these sediment samples was measured using a 7-day Hyalella azteca survival and growth test. Sixty-five sites (14.5%) exhibited lethal toxicity, and 130 sites (29.1%) exhibited decreased growth. In the EMAP-GRE probabilistic sampling design, each sampled site had a weight associated with it that determined the length (and proportion) of the river represented by that sample point in the population. Weighted whole-river estimates indicated that of the 4721 river km sampled, sediment from 15.9 +/- 3.0% of the river (752 +/- 50 km) were lethally toxic, 27.4 +/- 3.5% (1289 +/- 57 km) were toxic by way of growth inhibition, and 40.0 +/- 3.7% (1887 +/- 68 km) exhibited either lethal or growth toxicity. Selected toxic samples were analyzed for 21 pesticides, 20 polychlorinated biphenyl congeners, and 6 polybrominated diphenyl ether congeners. For all of the samples tested, the concentration levels of these analytes were mostly lower than known toxicity thresholds, and neither unionized ammonia concentration nor osmotic stress (as measured by conductivity) could account for the toxicity found in sediments. The spatial pattern of sediment toxicity cannot be readily explained by urbanization or agricultural land use at the subcatchment scale. We speculate that the distribution of toxic sediment is more likely due to a combination of localized sources, including polluted tributaries, and the redistribution of contaminated sediments from upriver. The sediment toxicity results from this study will be used, in combination with other sediment, biologic, and habitat metrics and indicators collected in the EMAP-GRE study, to help interpret and assess the condition of the Ohio, Upper Mississippi, and Missouri Rivers.
C1 [Haring, Herman J.; Smith, Mark E.; Wratschko, Melissa C.; Armstrong, Brandon; Lazorchak, James M.] US EPA, McConnell Grp, Natl Exposure Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA.
[Blocksom, Karen A.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Corvallis, OR 97333 USA.
[Angradi, Theodore; Bolgrien, David] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Duluth, MN 55804 USA.
RP Lazorchak, JM (reprint author), US EPA, McConnell Grp, Natl Exposure Res Lab, Off Res & Dev, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM lazorchak.jim@epa.gov
OI Lazorchak, James/0000-0002-7354-7571
FU USEPA
FX The research reported in this document was funded by the USEPA. This
manuscript has been subjected to review by the National Exposure
Research Laboratory and approved for publication. Approval does not
signify that the contents reflect the views of the Agency, nor does
mention of trade names or commercial products constitute endorsement or
recommendation for use. We thank Amy Parks, Gerilyn Ahlers, and Sarah
Watson for the chemical analyses of the sediment samples found to be
toxic. Review comments provided by Mari Nord and John Dorkin, USEPA,
Region 5, and Frank McCormick, United States Forest Service, were most
helpful, as was the technical review provided by Justicia Rhodus,
Dynamac Corporation.
NR 36
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U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0090-4341
EI 1432-0703
J9 ARCH ENVIRON CON TOX
JI Arch. Environ. Contam. Toxicol.
PD JAN
PY 2011
VL 60
IS 1
BP 57
EP 67
DI 10.1007/s00244-010-9592-4
PG 11
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 711OE
UT WOS:000286600500006
PM 20799029
ER
PT J
AU Mirabelli, MC
Hoppin, JA
Chatterjee, AB
Isom, S
Chen, HY
Grzywacz, JG
Howard, TD
Quandt, SA
Vallejos, QM
Arcury, TA
AF Mirabelli, Maria C.
Hoppin, Jane A.
Chatterjee, Arjun B.
Isom, Scott
Chen, Haiying
Grzywacz, Joseph G.
Howard, Timothy D.
Quandt, Sara A.
Vallejos, Quirina M.
Arcury, Thomas A.
TI Job Activities and Respiratory Symptoms Among Farmworkers in North
Carolina
SO ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
LA English
DT Article
DE agriculture; asthma; epidemiology; occupational lung disease;
respiratory diseases
ID AGRICULTURAL HEALTH; WORKING ENVIRONMENT; FARMERS EXPOSURE; MIGRANT;
DUST; PESTICIDES; RISK
AB Respiratory health is an important component of the ability to perform physically demanding work. The authors assessed respiratory symptom prevalence among Latino farmworkers engaged in crop production, and investigated work activities as risk factors for respiratory symptoms. During June to September 2008, 122 farmworkers completed up to 3 questionnaires. The authors estimated associations between work activities and wheezing symptoms using alternating logistic regression, controlling for age and smoking. At the first data collection, 29 (24%) farmworkers reported ever wheezing and 10 (8%) reported wheezing within the past month. Though not statistically significant, the odds of wheezing were elevated for individuals who reported performing tobacco-related work in the last 3 days. The odds were decreased among individuals who reported harvesting activities (odds ratio: 0.3, 95% confidence interval: 0.1, 1.0). Among Latino farmworkers, respiratory symptoms may be associated with work activities.
C1 [Mirabelli, Maria C.; Quandt, Sara A.] Wake Forest Sch Med, Dept Epidemiol & Prevent, Div Publ Hlth Sci, Winston Salem, NC 27157 USA.
[Hoppin, Jane A.] Natl Inst Environm Hlth Sci, Epidemiol Branch, NIH, Res Triangle Pk, NC USA.
[Chatterjee, Arjun B.] Wake Forest Sch Med, Dept Internal Med, Sect Pulm Crit Care Allergy & Immunol Dis, Winston Salem, NC 27157 USA.
[Isom, Scott; Chen, Haiying] Wake Forest Sch Med, Dept Biostat Sci, Div Publ Hlth Sci, Winston Salem, NC 27157 USA.
[Grzywacz, Joseph G.; Vallejos, Quirina M.; Arcury, Thomas A.] Wake Forest Sch Med, Dept Family & Community Med, Winston Salem, NC 27157 USA.
[Chatterjee, Arjun B.; Grzywacz, Joseph G.; Quandt, Sara A.; Vallejos, Quirina M.] Wake Forest Sch Med, Ctr Worker Hlth, Winston Salem, NC 27157 USA.
[Howard, Timothy D.] Wake Forest Sch Med, Ctr Genom & Personalized Med Res, Winston Salem, NC 27157 USA.
RP Mirabelli, MC (reprint author), Wake Forest Sch Med, Dept Epidemiol & Prevent, Div Publ Hlth Sci, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM mmirabel@wakehealth.edu
RI chatterjee, arjun/H-2689-2013;
OI chatterjee, arjun/0000-0001-8221-873X; Mirabelli,
Maria/0000-0002-3540-0085; Grzywacz, Joseph/0000-0002-2308-7781
FU National Institutes of Health, National Institute of Environmental
Health Sciences [R01ES008739, Z01ES049030]
FX This work was supported by the National Institutes of Health, National
Institute of Environmental Health Sciences (grant number: R01ES008739)
and the Intramural Research Program of the National Institutes of
Health, National Institute of Environmental Health Sciences (grant
number: Z01ES049030).
NR 21
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U1 0
U2 11
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1933-8244
J9 ARCH ENVIRON OCCUP H
JI Arch. Environ. Occup. Health
PY 2011
VL 66
IS 3
BP 178
EP 182
DI 10.1080/19338244.2010.539637
PG 5
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA 888HO
UT WOS:000299994700006
PM 21864106
ER
PT J
AU O'Hanlon, TP
Rider, LG
Gan, L
Fannin, R
Paules, RS
Umbach, DM
Weinberg, CR
Shah, RR
Mav, D
Gourley, MF
Miller, FW
AF O'Hanlon, Terrance P.
Rider, Lisa G.
Gan, Lu
Fannin, Rick
Paules, Richard S.
Umbach, David M.
Weinberg, Clarice R.
Shah, Ruchir R.
Mav, Deepak
Gourley, Mark F.
Miller, Frederick W.
TI Gene expression profiles from discordant monozygotic twins suggest that
molecular pathways are shared among multiple systemic autoimmune
diseases
SO ARTHRITIS RESEARCH & THERAPY
LA English
DT Article
ID PERIPHERAL-BLOOD CELLS; RHEUMATOID-ARTHRITIS PATIENTS; GENOME-WIDE
ASSOCIATION; LUPUS-ERYTHEMATOSUS; INFLAMMATORY MYOPATHIES; FAMILIAL
AGGREGATION; MONONUCLEAR-CELLS; IDENTIFICATION; DERMATOMYOSITIS;
SIGNATURES
AB Introduction: The objective of this study is to determine if multiple systemic autoimmune diseases (SAID) share gene expression pathways that could provide insights into pathogenic mechanisms common to these disorders.
Methods: RNA microarray analyses (Agilent Human 1A(V2) 20K oligo arrays) were used to quantify gene expression in peripheral blood cells from 20 monozygotic (MZ) twin pairs discordant for SAID. Six affected probands with systemic lupus erythematosus (SLE), six with rheumatoid arthritis (RA), eight with idiopathic inflammatory myopathies (IIM), and their same-gendered unaffected twins, were enrolled. Comparisons were made between discordant twin pairs and these were also each compared to 40 unrelated control subjects (matched 2: 1 to each twin by age, gender and ethnicity) using statistical and molecular pathway analyses. Relative quantitative PCR was used to verify independently measures of differential gene expression assessed by microarray analysis.
Results: Probands and unrelated, matched controls differed significantly in gene expression for 104 probes corresponding to 92 identifiable genes (multiple-comparison adjusted P values < 0.1). Differentially expressed genes involved several overlapping pathways including immune responses (16%), signaling pathways (24%), transcription/translation regulators (26%), and metabolic functions (15%). Interferon (IFN)-response genes (IFI27, OASF, PLSCR1, EIF2AK2, TNFAIP6, and TNFSF10) were up-regulated in probands compared to unrelated controls. Many of the abnormally expressed genes played regulatory roles in multiple cellular pathways. We did not detect any probes expressed differentially in comparisons among the three SAID phenotypes. Similarly, we found no significant differences in gene expression when comparing probands to unaffected twins or unaffected twins to unrelated controls. Gene expression levels for unaffected twins appeared intermediate between that of probands and unrelated controls for 6535 probes (32% of the total probes) as would be expected by chance. By contrast, in unaffected twins intermediate ordering was observed for 84 of the 104 probes (81%) whose expression differed significantly between probands and unrelated controls.
Conclusions: Alterations in expression of a limited number of genes may influence the dysregulation of numerous, integrated immune response, cell signaling and regulatory pathways that are common to a number of SAID. Gene expression profiles in peripheral blood suggest that for genes in these critical pathways, unaffected twins may be in a transitional or intermediate state of immune dysregulation between twins with SAID and unrelated controls, perhaps predisposing them to the development of SAID given the necessary and sufficient environmental exposures.
C1 [O'Hanlon, Terrance P.; Rider, Lisa G.; Gan, Lu; Miller, Frederick W.] Natl Inst Environm Hlth Sci, Environm Autoimmun Grp, NIH, Bethesda, MD 20892 USA.
[Fannin, Rick; Paules, Richard S.] Natl Inst Environm Hlth Sci, Lab Toxicol & Pharmacol, NIH, Res Triangle Pk, NC 27709 USA.
[Umbach, David M.; Weinberg, Clarice R.] Natl Inst Environm Hlth Sci, Biostat Branch, NIH, Res Triangle Pk, NC 27709 USA.
[Shah, Ruchir R.; Mav, Deepak] SRA Int Inc, Durham, NC 27713 USA.
[Gourley, Mark F.] Natl Inst Arthrit & Musculoskeletal Dis, NIH, Bethesda, MD 20892 USA.
RP O'Hanlon, TP (reprint author), Natl Inst Environm Hlth Sci, Environm Autoimmun Grp, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM ohanlont@niehs.nih.gov
RI Gan, Lu/L-5395-2014;
OI Rider, Lisa/0000-0002-6912-2458; Miller, Frederick/0000-0003-2831-9593
FU National Institute of Environmental Health Sciences
FX The authors thank Robert Colbert and Nina Raben for their critical
review of the manuscript. This work was supported by the intramural
research program of the National Institute of Environmental Health
Sciences. The funding sponsors had no role in the design, conduct, or
interpretation of the study. The content of this publication does not
necessarily reflect the views or policies of the US Department of Health
and Human Services, nor does the mention of trade names, commercial
products, or organizations imply endorsement by the US Government.
NR 37
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Z9 19
U1 1
U2 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1478-6354
J9 ARTHRITIS RES THER
JI Arthritis Res. Ther.
PY 2011
VL 13
IS 2
AR R69
DI 10.1186/ar3330
PG 13
WC Rheumatology
SC Rheumatology
GA 788MS
UT WOS:000292449700034
PM 21521520
ER
PT B
AU Breggin, LK
Falkner, R
Pendergrass, J
Porter, R
Jaspers, N
AF Breggin, Linda K.
Falkner, Robert
Pendergrass, John
Porter, Read
Jaspers, Nico
BE Ramachandran, G
TI Addressing the Risks of Nanomaterials under United States and European
Union Regulatory Frameworks for Chemicals
SO ASSESSING NANOPARTICLE RISKS TO HUMAN HEALTH
LA English
DT Article; Book Chapter
ID NANOTECHNOLOGY
C1 [Breggin, Linda K.] Environm Law Inst, Nanotechnol Initiat, Washington, DC 20036 USA.
[Breggin, Linda K.] White House Off Environm Policy, Washington, DC USA.
[Breggin, Linda K.] US EPA, Washington, DC 20460 USA.
[Breggin, Linda K.] US House Representat, Comm Energy & Commerce, Subcomm Transportat & Hazardous Mat, Washington, DC 20515 USA.
[Falkner, Robert] London Sch Econ & Polit Sci LSE, London, England.
[Falkner, Robert] LSE Global Governance, Zurich, Switzerland.
[Falkner, Robert] LSE, Nanotechnol Policy & Regulat Program, Zurich, Switzerland.
[Pendergrass, John] Environm Law Inst, Judicial Educ Program, Washington, DC 20036 USA.
[Pendergrass, John] US Dept Interior, Washington, DC 20240 USA.
[Porter, Read] Environm Law Inst, Washington, DC 20036 USA.
[Jaspers, Nico] Univ London London Sch Econ & Polit Sci, Dept Int Relat, London WC2A 2AE, England.
[Jaspers, Nico] Univ London London Sch Econ & Polit Sci, London WC2A 2AE, England.
RP Breggin, LK (reprint author), Environm Law Inst, Nanotechnol Initiat, Washington, DC 20036 USA.
NR 79
TC 1
Z9 1
U1 1
U2 1
PU WILLIAM ANDREW INC
PI NORWICH
PA 13 EATON AVE, NORWICH, NY 13815 USA
BN 978-1-4377-7864-9
PY 2011
BP 195
EP 272
DI 10.1016/B978-1-4377-7863-2.00008-X
PG 78
WC Public, Environmental & Occupational Health; Nanoscience &
Nanotechnology
SC Public, Environmental & Occupational Health; Science & Technology -
Other Topics
GA BFK38
UT WOS:000320229200009
ER
PT J
AU Li, L
Chen, CH
Fu, JS
Huang, C
Streets, DG
Huang, HY
Zhang, GF
Wang, YJ
Jang, CJ
Wang, HL
Chen, YR
Fu, JM
AF Li, L.
Chen, C. H.
Fu, J. S.
Huang, C.
Streets, D. G.
Huang, H. Y.
Zhang, G. F.
Wang, Y. J.
Jang, C. J.
Wang, H. L.
Chen, Y. R.
Fu, J. M.
TI Air quality and emissions in the Yangtze River Delta, China
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID MODELING SYSTEM; EAST-ASIA; OZONE POLLUTION; GASEOUS-POLLUTANTS;
BOUNDARY-LAYER; RURAL SITE; SHANGHAI; SO2; NOX; SENSITIVITY
AB Regional trans-boundary air pollution has become an important issue in the field of air pollution modeling. This paper presents the results of the implementation of the MM5-CMAQ modeling system in the Yangtze River Delta (YRD) for the months of January and July of 2004. The meteorological parameters are obtained by using the MM5 model. A new regional emission inventory with spatial and temporal allocations based on local statistical data has been developed to provide input emissions data to the MM5-CMAQ modeling system. The pollutant concentrations obtained from the MM5-CMAQ modeling system have been compared with observational data from the national air pollution monitoring network. It is found that air quality in winter in the YRD is generally worse than in summer, due mainly to unfavorable meteorological dispersion conditions. In winter, the pollution transport from Northern China to the YRD reinforces the pollution caused by large local emissions. The monthly average concentration of SO2 in the YRD is 0.026 +/- 0.011 mg m(-3) in January and 0.017 +/- 0.009 mg m(-3) in July. Monthly average concentrations of NO2 in the YRD in January and July are 0.021 +/- 0.009 mg m(-3), and 0.014 +/- 0.008 mg m(-3), respectively. The monthly average concentration of PM10 in the YRD is 0.080 +/- 0.028 mg m(-3) in January and 0.025 +/- 0.015 mg m(-3) in July. Visibility is also a problem, with average deciview values of 26.4 +/- 2.95 dcv in winter and 17.6 +/- 3.3 dcv in summer. The ozone concentration in the downtown area of a city like Zhoushan can be very high, with the highest simulated value reaching 0.24 mg m(-3). In January, the monthly average concentration of O-3 in the YRD is 0.052 +/- 0.011 mg m(-3), and 0.054 +/- 0.008 mg m(-3) in July. Our results show that ozone and haze have become extremely important issues in the regional air quality. Thus, regional air pollution control is urgently needed to improve air quality in the YRD.
C1 [Li, L.; Chen, C. H.; Huang, C.; Huang, H. Y.; Zhang, G. F.; Wang, H. L.; Chen, Y. R.] Shanghai Acad Environm Sci, Shanghai 200233, Peoples R China.
[Fu, J. S.] Univ Tennessee, Dept Civil & Environm Engn, Knoxville, TN 37996 USA.
[Streets, D. G.] Argonne Natl Lab, Decis & Informat Sci Div, Argonne, IL 60439 USA.
[Wang, Y. J.; Fu, J. M.] Shanghai Univ, Sch Environm & Chem Engn, Inst Environm Pollut & Hlth, Shanghai 200444, Peoples R China.
[Jang, C. J.] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
RP Chen, CH (reprint author), Shanghai Acad Environm Sci, Shanghai 200233, Peoples R China.
EM chench@saes.sh.cn
RI Xiongfei, Zhao/G-7690-2015; Huang, Cheng/I-7099-2015;
OI Streets, David/0000-0002-0223-1350
FU Chinese National Key Technology RD Program [2009BAK43B33]
FX This study was supported by the "Chinese National Key Technology R&D
Program" via grants 2009BAK43B33. The authors would like to thank US EPA
for providing the CMAQ model code, full model documentation, and
assistance with model set-up and running. We also appreciate the
suggestions made by the two kind reviewers that helped greatly to
improve this paper.
NR 50
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Z9 64
U1 4
U2 87
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2011
VL 11
IS 4
BP 1621
EP 1639
DI 10.5194/acp-11-1621-2011
PG 19
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 727JW
UT WOS:000287795700016
ER
PT J
AU Chan, MN
Surratt, JD
Chan, AWH
Schilling, K
Offenberg, JH
Lewandowski, M
Edney, EO
Kleindienst, TE
Jaoui, M
Edgerton, ES
Tanner, RL
Shaw, SL
Zheng, M
Knipping, EM
Seinfeld, JH
AF Chan, M. N.
Surratt, J. D.
Chan, A. W. H.
Schilling, K.
Offenberg, J. H.
Lewandowski, M.
Edney, E. O.
Kleindienst, T. E.
Jaoui, M.
Edgerton, E. S.
Tanner, R. L.
Shaw, S. L.
Zheng, M.
Knipping, E. M.
Seinfeld, J. H.
TI Influence of aerosol acidity on the chemical composition of secondary
organic aerosol from beta-caryophyllene
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID BIOGENIC HYDROCARBONS; UNITED-STATES; ORGANOSULFATE FORMATION;
OXIDATION-PRODUCTS; PINENE OZONOLYSIS; AMBIENT AEROSOL; PHASE REACTIONS;
HONG-KONG; ISOPRENE; GAS
AB The secondary organic aerosol (SOA) yield of beta-caryophyllene photooxidation is enhanced by aerosol acidity. In the present study, the influence of aerosol acidity on the chemical composition of beta-caryophyllene SOA is investigated using ultra performance liquid chromatography/electrospray ionization-time-of-flight mass spectrometry (UPLC/ESI-TOFMS). A number of first-, second- and higher-generation gas-phase products having carbonyl and carboxylic acid functional groups are detected in the particle phase. Particle-phase reaction products formed via hydration and organosulfate formation processes are also detected. Increased acidity leads to different effects on the abundance of individual products; significantly, abundances of organosulfates are correlated with aerosol acidity. To our knowledge, this is the first detection of organosulfates and nitrated organosulfates derived from a sesquiterpene. The increase of certain particle-phase reaction products with increased acidity provides chemical evidence to support the acid-enhanced SOA yields. Based on the agreement between the chromatographic retention times and accurate mass measurements of chamber and field samples, three beta-caryophyllene products (i.e., beta-nocaryophyllon aldehyde, beta-hydroxynocaryophyllon aldehyde, and beta-dihydroxynocaryophyllon aldehyde) are suggested as chemical tracers for beta-caryophyllene SOA. These compounds are detected in both day and night ambient samples collected in downtown Atlanta, GA and rural Yorkville, GA during the 2008 August Mini-Intensive Gas and Aerosol Study (AMIGAS).
C1 [Chan, M. N.; Seinfeld, J. H.] CALTECH, Div Engn & Appl Sci, Pasadena, CA 91125 USA.
[Surratt, J. D.; Chan, A. W. H.; Schilling, K.; Seinfeld, J. H.] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA.
[Offenberg, J. H.; Lewandowski, M.; Edney, E. O.; Kleindienst, T. E.] US EPA, Natl Exposure Res Lab, Human Exposure Atmospher Sci Div, Res Triangle Pk, NC 27711 USA.
[Jaoui, M.] Alion Sci & Technol, Res Triangle Pk, NC USA.
[Edgerton, E. S.] Atmospher Res & Anal Inc, Cary, NC USA.
[Tanner, R. L.] Tennessee Valley Author, Muscle Shoals, AL USA.
[Shaw, S. L.] Elect Power Res Inst, Palo Alto, CA USA.
[Zheng, M.] Georgia Inst Technol, Sch Earth & Atmospher Sci, Atlanta, GA 30332 USA.
[Knipping, E. M.] Elect Power Res Inst, Washington, DC USA.
RP Seinfeld, JH (reprint author), CALTECH, Div Engn & Appl Sci, Pasadena, CA 91125 USA.
EM seinfeld@caltech.edu
RI Chan, Arthur/I-2233-2013; Offenberg, John/C-3787-2009; Surratt,
Jason/D-3611-2009
OI Chan, Arthur/0000-0001-7392-4237; Offenberg, John/0000-0002-0213-4024;
Surratt, Jason/0000-0002-6833-1450
FU Electric Power Research Institute; Southern Company, Birmingham, AL; US
Environmental Protection Agency through its Office of Research and
Development [68-D-00-206]
FX This work was supported by the Electric Power Research Institute and the
Southern Company, Birmingham, AL. We acknowledge all members of the
AMIGAS for their support during the field campaign. The US Environmental
Protection Agency through its Office of Research and Development funded
and collaborated in the research described here under Contract
68-D-00-206 to Alion Science and Technology. It has been subject to
Agency review and approved for publication. Mention of trade names or
commercial products does not constitute an endorsement or recommendation
for use.
NR 48
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PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2011
VL 11
IS 4
BP 1735
EP 1751
DI 10.5194/acp-11-1735-2011
PG 17
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 727JW
UT WOS:000287795700024
ER
PT J
AU Simon, H
Bhave, PV
Swall, JL
Frank, NH
Malm, WC
AF Simon, H.
Bhave, P. V.
Swall, J. L.
Frank, N. H.
Malm, W. C.
TI Determining the spatial and seasonal variability in OM/OC ratios across
the US using multiple regression
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID ORGANIC-CARBON RATIO; AEROSOL MASS-SPECTROMETER; UNITED-STATES;
OPTICAL-PROPERTIES; LIGHT EXTINCTION; PM2.5 MASS; IMPROVE; SECONDARY;
PARTICLES; LOCATION
AB Data from the Interagency Monitoring of Protected Visual Environments (IMPROVE) network are used to estimate organic mass to organic carbon (OM/OC) ratios across the United States by extending previously published multiple regression techniques. Our new methodology addresses common pitfalls of multiple regression including measurement uncertainty, colinearity of covariates, dataset selection, and model selection. As expected, summertime OM/OC ratios are larger than wintertime values across the US with all regional median OM/OC values tightly confined between 1.80 and 1.95. Further, we find that OM/OC ratios during the winter are distinctly larger in the eastern US than in the West (regional medians are 1.58, 1.64, and 1.85 in the great lakes, southeast, and northeast regions, versus 1.29 and 1.32 in the western and central states). We find less spatial variability in long-term averaged OM/OC ratios across the US (90% of our multiyear regressions estimate OM/OC ratios between 1.37 and 1.94) than previous studies (90% fell between 1.30 and 2.10). We attribute this difference largely to the inclusion of EC as a covariate in previous regression studies. Due to the colinearity of EC and OC, we find that up to one-quarter of the OM/OC estimates in a previous study are biased low. Assumptions about OC measurement artifacts add uncertainty to our estimates of OM/OC. In addition to estimating OM/OC ratios, our technique reveals trends that may be contrasted with conventional assumptions regarding nitrate, sulfate, and soil across the IMPROVE network. For example, our regressions show pronounced seasonal and spatial variability in both nitrate volatilization and sulfate neutralization and hydration.
C1 [Simon, H.; Frank, N. H.] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
[Bhave, P. V.; Swall, J. L.] US EPA, Natl Exposure Res Lab, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA.
[Malm, W. C.] Colorado State Univ, Cooperat Inst Res Atmosphere, Natl Pk Serv, Ft Collins, CO 80523 USA.
RP Simon, H (reprint author), US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
EM simon.heather@epa.gov
RI simon, heather/E-4392-2011; Bhave, Prakash/L-1958-2013
OI Swall, Jenise/0000-0001-8728-5771; simon, heather/0000-0001-7254-3360;
Bhave, Prakash/0000-0002-2573-951X
FU United States Environmental Protection Agency through its Office of
Research and Development
FX The authors thank Warren White for helpful information on IMPROVE
chloride measurements and regression methods, Chuck McDade for IMPROVE
laboratory RH data, Lowell Ashbaugh for IMPROVE OC back-up filter
measurement data, Doug Lowenthal for details of his mass closure
methods, and Mark Pitchford, Venkatesh Rao, Ann Dillner, and Steve McDow
for miscellaneous feedback and encouragement. The United States
Environmental Protection Agency through its Office of Research and
Development funded and managed the research described here. It has been
subjected to Agency's administrative review and approved for
publication.
NR 50
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U1 2
U2 28
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2011
VL 11
IS 6
BP 2933
EP 2949
DI 10.5194/acp-11-2933-2011
PG 17
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 742YW
UT WOS:000288982300033
ER
PT J
AU Xing, J
Wang, SX
Jang, C
Zhu, Y
Hao, JM
AF Xing, J.
Wang, S. X.
Jang, C.
Zhu, Y.
Hao, J. M.
TI Nonlinear response of ozone to precursor emission changes in China: a
modeling study using response surface methodology
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID AIR-QUALITY MODEL; VOLATILE ORGANIC-COMPOUNDS; RIVER DELTA REGION;
SOURCE APPORTIONMENT; SENSITIVITY-ANALYSIS; PARTICULATE MATTER;
POLLUTION-CONTROL; CONTROL STRATEGIES; INVENTORY; NOX
AB Statistical response surface methodology (RSM) is successfully applied for a Community Multi-scale Air Quality model (CMAQ) analysis of ozone sensitivity studies. Prediction performance has been demonstrated through cross validation, out-of-sample validation and isopleth validation. Sample methods and key parameters, including the maximum numbers of variables involved in statistical interpolation and training samples have been tested and selected through computational experiments. Overall impacts from individual source categories which include local/regional NOx and VOC emission sources and NOx emissions from power plants for three megacities - Beijing, Shanghai and Guangzhou - were evaluated using an RSM analysis of a July 2005 modeling study. NOx control appears to be beneficial for ozone reduction in the downwind areas which usually experience high ozone levels, and NOx control is likely to be more effective than anthropogenic VOC control during periods of heavy photochemical pollution. Regional NOx source categories are strong contributors to surface ozone mixing ratios in three megacities. Local NOx emission control without regional involvement may raise the risk of increasing urban ozone levels due to the VOC-limited conditions. However, local NOx control provides considerable reduction of ozone in upper layers (up to 1 km where the ozone chemistry is NOx-limited) and helps improve regional air quality in downwind areas. Stricter NOx emission control has a substantial effect on ozone reduction because of the shift from VOC-limited to NOx-limited chemistry. Therefore, NOx emission control should be significantly enhanced to reduce ozone pollution in China.
C1 [Xing, J.; Wang, S. X.; Hao, J. M.] Tsinghua Univ, Sch Environm, Beijing 100084, Peoples R China.
[Xing, J.; Wang, S. X.; Hao, J. M.] Tsinghua Univ, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China.
[Jang, C.] US EPA, Res Triangle Pk, NC 27711 USA.
[Zhu, Y.] S China Univ Technol, Sch Environm Sci & Engn, Guangzhou 510006, Guangdong, Peoples R China.
RP Wang, SX (reprint author), Tsinghua Univ, Sch Environm, Beijing 100084, Peoples R China.
EM shxwang@tsinghua.edu.cn
RI hui, wanghui/C-5671-2008; xing, jia/O-1784-2014; wang,
shuxiao/H-5990-2011
OI wang, shuxiao/0000-0001-9727-1963
FU National High Technology Research and Development Program of China
[2006AA06A309]; Natural Science Foundation of China [20921140409]; U.S.
EPA
FX The study was financially supported by the National High Technology
Research and Development Program of China (2006AA06A309), Natural
Science Foundation of China (20921140409), and U.S. EPA. The authors
thank to Thomas J. Santner and Gang Han at Ohio State University for
their help on MperK program; Jeremy Schreifels and Chuck Cnfreed from
U.S. EPA for their great help in editing.
NR 55
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U2 71
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2011
VL 11
IS 10
BP 5027
EP 5044
DI 10.5194/acp-11-5027-2011
PG 18
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 770NU
UT WOS:000291094500029
ER
PT J
AU Anenberg, SC
Talgo, K
Arunachalam, S
Dolwick, P
Jang, C
West, JJ
AF Anenberg, S. C.
Talgo, K.
Arunachalam, S.
Dolwick, P.
Jang, C.
West, J. J.
TI Impacts of global, regional, and sectoral black carbon emission
reductions on surface air quality and human mortality
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID EVALUATING INTERCONTINENTAL TRANSPORT; BIOMASS BURNING EMISSIONS; FINE
PARTICULATE MATTER; FOSSIL-FUEL; TROPOSPHERIC OXIDANTS; PHOTOCHEMICAL
SMOG; PHOTOLYSIS RATES; OZONE POLLUTION; HEALTH-BENEFITS; MEXICO-CITY
AB As a component of fine particulate matter (PM2.5), black carbon (BC) is associated with premature human mortality. BC also affects climate by absorbing solar radiation and reducing planetary albedo. Several studies have examined the climate impacts of BC emissions, but the associated health impacts have been studied less extensively. Here, we examine the surface PM2.5 and premature mortality impacts of halving anthropogenic BC emissions globally and individually from eight world regions and three major economic sectors. We use a global chemical transport model, MOZART-4, to simulate PM2.5 concentrations and a health impact function to calculate premature cardiopulmonary and lung cancer deaths. We estimate that halving global anthropogenic BC emissions reduces outdoor population-weighted average PM2.5 by 542 ngm(-3) (1.8 %) and avoids 157 000 (95% confidence interval, 120 000-194 000) annual premature deaths globally, with the vast majority occurring within the source region. Most of these avoided deaths can be achieved by halving emissions in East Asia (China; 54 %), followed by South Asia (India; 31 %), however South Asian emissions have 50% greater mortality impacts per unit BC emitted than East Asian emissions. Globally, halving residential, industrial, and transportation emissions contributes 47 %, 35 %, and 15% to the avoided deaths from halving all anthropogenic BC emissions. These contributions are 1.2, 1.2, and 0.6 times each sector's portion of global BC emissions, owing to the degree of co-location with population globally. We find that reducing BC emissions increases regional SO4 concentrations by up to 28% of the magnitude of the regional BC concentration reductions, due to reduced absorption of radiation that drives photochemistry. Impacts of residential BC emissions are likely underestimated since indoor PM2.5 exposure is excluded. We estimate similar to 8 times more avoided deaths when BC and organic carbon (OC) emissions are halved together, suggesting that these results greatly underestimate the full air pollution-related mortality benefits of BC mitigation strategies which generally decrease both BC and OC. The choice of concentration-response factor and health effect thresholds affects estimated global avoided deaths by as much as 56% but does not strongly affect the regional distribution. Confidence in our results would be strengthened by reducing uncertainties in emissions, model parameterization of aerosol processes, grid resolution, and PM2.5 concentration-mortality relationships globally.
C1 [Anenberg, S. C.; West, J. J.] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27515 USA.
[Anenberg, S. C.; Dolwick, P.; Jang, C.] US EPA, Res Triangle Pk, NC 27711 USA.
[Talgo, K.; Arunachalam, S.] Univ N Carolina, Inst Environm, Chapel Hill, NC USA.
RP West, JJ (reprint author), Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27515 USA.
EM jjwest@email.unc.edu
RI West, Jason/J-2322-2015
OI West, Jason/0000-0001-5652-4987
FU EPA Office of Air Quality Planning; National Institute of Environmental
Health Sciences [P30ES10126]
FX The opinions expressed in this article are the authors' and do not
necessarily represent those of the US EPA. This work was supported in
part by the EPA Office of Air Quality Planning and Standards and a grant
from the National Institute of Environmental Health Sciences
(P30ES10126). We thank L. Emmons, S. Walters, S. Liu, and Z. Adelman for
assistance with MOZART-4, J. Liu for assistance with the model
evaluation, and N. Frank, T. Rao, E. Sasser, B. Hubbell, D. Leith, W.
Vizuete, and K. Yeatts for valuable insights. We also thank the entire
NCAR MOZART-4 development team for their efforts.
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PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2011
VL 11
IS 14
BP 7253
EP 7267
DI 10.5194/acp-11-7253-2011
PG 15
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 797KI
UT WOS:000293125100030
ER
PT J
AU Richard, A
Gianini, MFD
Mohr, C
Furger, M
Bukowiecki, N
Minguillon, MC
Lienemann, P
Flechsig, U
Appel, K
DeCarlo, PF
Heringa, MF
Chirico, R
Baltensperger, U
Prevot, ASH
AF Richard, A.
Gianini, M. F. D.
Mohr, C.
Furger, M.
Bukowiecki, N.
Minguillon, M. C.
Lienemann, P.
Flechsig, U.
Appel, K.
DeCarlo, P. F.
Heringa, M. F.
Chirico, R.
Baltensperger, U.
Prevot, A. S. H.
TI Source apportionment of size and time resolved trace elements and
organic aerosols from an urban courtyard site in Switzerland
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID POSITIVE MATRIX FACTORIZATION; RAY-FLUORESCENCE SPECTROMETRY;
PARTICULATE MATTER; MASS-SPECTROMETER; ATMOSPHERIC AEROSOL;
CHEMICAL-COMPOSITION; SYNCHROTRON-XRF; HIGH-RESOLUTION; AMBIENT; AIR
AB Time and size resolved data of trace elements were obtained from measurements with a rotating drum impactor (RDI) and subsequent X-ray fluorescence spectrometry. Trace elements can act as indicators for the identification of sources of particulate matter <10 mu m (PM(10)) in ambient air. Receptor modeling was performed with positive matrix factorization (PMF) for trace element data from an urban background site in Zurich, Switzerland. Eight different sources were identified for the three examined size ranges (PM(1-0.1), PM(2.5-1) and PM(10-2.5)): secondary sulfate, wood combustion, fire works, road traffic, mineral dust, de-icing salt, industrial and local anthropogenic activities. The major component was secondary sulfate for the smallest size range; the road traffic factor was found in all three size ranges. This trace element analysis is complemented with data from an Aerodyne high-resolution time-of-flight aerosol mass spectrometer (AMS), assessing the PM(1) fraction of organic aerosols. A separate PMF analysis revealed three factors related to three of the sources found with the RDI: oxygenated organic aerosol (OOA, related to inorganic secondary sulfate), hydrocarbon-like organic aerosol (HOA, related to road traffic) and biomass burning organic aerosol (BBOA), explaining 60 %, 22% and 17% of total measured organics, respectively. Since different compounds are used for the source classification, a higher percentage of the ambient PM(10) mass concentration can be apportioned to sources by the combination of both methods.
C1 [Richard, A.; Mohr, C.; Furger, M.; Bukowiecki, N.; Minguillon, M. C.; Heringa, M. F.; Chirico, R.; Baltensperger, U.; Prevot, A. S. H.] Paul Scherrer Inst, Lab Atmospher Chem, Villigen, Switzerland.
[Gianini, M. F. D.] Empa, Lab Air Pollut & Environm Technol, Swiss Fed Labs Mat Sci & Technol, Dubendorf, Switzerland.
[Minguillon, M. C.] CSIC, Inst Environm Assessment & Water Res IDAEA, Barcelona, Spain.
[Lienemann, P.] Sch Life Sci & Facil Management, Wadenswil, Switzerland.
[Flechsig, U.] Paul Scherrer Inst, Swiss Light Source, Villigen, Switzerland.
[Appel, K.] Helmholtz Assoc, Hamburger Synchrotronstrahlungslabor, Deutsch Elektronen Synchrotron DESY, Res Ctr, Hamburg, Germany.
[DeCarlo, P. F.] US EPA, Washington, DC USA.
[Chirico, R.] FIS LAS, Italian Natl Agcy New Technol Energy & Sustainabl, Frascati, Italy.
RP Furger, M (reprint author), Paul Scherrer Inst, Lab Atmospher Chem, Villigen, Switzerland.
EM markus.furger@psi.ch
RI Heringa, Maarten/A-7506-2010; Mohr, Claudia/D-9857-2011; Furger,
Markus/C-2224-2009; Prevot, Andre/C-6677-2008; Bukowiecki,
Nicolas/D-1941-2009; Minguillon, Maria Cruz/F-9431-2016
OI Mohr, Claudia/0000-0002-3291-9295; Furger, Markus/0000-0003-2401-6448;
Prevot, Andre/0000-0002-9243-8194;
NR 60
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U1 6
U2 34
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2011
VL 11
IS 17
BP 8945
EP 8963
DI 10.5194/acp-11-8945-2011
PG 19
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 819EW
UT WOS:000294809200008
ER
PT J
AU Shephard, MW
Cady-Pereira, KE
Luo, M
Henze, DK
Pinder, RW
Walker, JT
Rinsland, CP
Bash, JO
Zhu, L
Payne, VH
Clarisse, L
AF Shephard, M. W.
Cady-Pereira, K. E.
Luo, M.
Henze, D. K.
Pinder, R. W.
Walker, J. T.
Rinsland, C. P.
Bash, J. O.
Zhu, L.
Payne, V. H.
Clarisse, L.
TI TES ammonia retrieval strategy and global observations of the spatial
and seasonal variability of ammonia
SO ATMOSPHERIC CHEMISTRY AND PHYSICS
LA English
DT Article
ID TROPOSPHERIC EMISSION SPECTROMETER; MOLECULAR SPECTROSCOPIC DATABASE;
UNITED-STATES; GEOS-CHEM; MODEL; SULFATE; NH3; INVENTORY; POLLUTION;
AEROSOLS
AB Presently only limited sets of tropospheric ammonia (NH3) measurements in the Earth's atmosphere have been reported from satellite and surface station measurements, despite the well-documented negative impact of NH3 on the environment and human health. Presented here is a detailed description of the satellite retrieval strategy and analysis for the Tropospheric Emission Spectrometer (TES) using simulations and measurements. These results show that: (i) the level of detectability for a representative boundary layer TES NH3 mixing ratio value is similar to 0.4 ppbv, which typically corresponds to a profile that contains a maximum level value of similar to 1 ppbv; (ii) TES NH3 retrievals generally provide at most one degree of freedom for signal (DOFS), with peak sensitivity between 700 and 900 mbar; (iii) TES NH3 retrievals show significant spatial and seasonal variability of NH3 globally; (iv) initial comparisons of TES observations with GEOS-CHEM estimates show TES values being higher overall. Important differences and similarities between modeled and observed seasonal and spatial trends are noted, with discrepancies indicating areas where the timing and magnitude of modeled NH3 emissions from agricultural sources, and to lesser extent biomass burning sources, need further study.
C1 [Shephard, M. W.] Environm Canada, Downsview, ON, Canada.
[Cady-Pereira, K. E.; Payne, V. H.] Atmospher & Environm Res Inc, Lexington, MA USA.
[Luo, M.] CALTECH, Jet Prop Lab, Pasadena, CA 91125 USA.
[Henze, D. K.; Zhu, L.] Univ Colorado, Boulder, CO 80309 USA.
[Pinder, R. W.; Walker, J. T.; Bash, J. O.] US EPA, Res Triangle Pk, NC 27711 USA.
[Clarisse, L.] Univ Libre Bruxelles, Serv Chim Quant & Photophys, Brussels, Belgium.
[Rinsland, C. P.] NASA, Langley Res Ctr, Hampton, VA 23665 USA.
RP Shephard, MW (reprint author), Atmospher & Climate Applicat ACApps Inc, E Gwillimbury, ON, Canada.
EM mark.shephard@acappsinc.com
RI Henze, Daven/A-1920-2012; Pinder, Robert/F-8252-2011; Payne,
Vivienne/D-9713-2012; Bash, Jesse/E-9688-2013; Chem, GEOS/C-5595-2014;
Walker, John/I-8880-2014
OI Bash, Jesse/0000-0001-8736-0102; Pinder, Robert/0000-0001-6390-7126;
Walker, John/0000-0001-6034-7514
FU Jet Propulsion Laboratory, California Institute of Technology; NASA
[NNX10AG63G, EPA-STAR RD83455901]
FX We would like to dedicate this article to our good friend and colleague
Curtis Rinsland who passed away during review process of this
publication. He was a very dedicated and accomplished scientist who will
be greatly missed by our scientific community. We would like to thank
Tom Connor, Alan Lipton, Jean-Luc Moncet, and Gennady Uymin of AER for
building an OSS version for TES. We would also like to thank Reinhard
Beer and Shepard A. (Tony) Clough for their initial retrieval support.
Research was partially supported by the Jet Propulsion Laboratory,
California Institute of Technology under contract to the National
Aeronautics and Space Administration (NASA). Contributions at CU Boulder
recognize support from NASA grant NNX10AG63G and EPA-STAR RD83455901.
Research at NASA Langley Research Center was supported under a proposal
funded by NASA. L. Clarisse is supported as a Postdoctoral Researcher
with F.R.S.-FNRS. Although this paper has been reviewed by both EC and
EPA and approved for publication, it does not necessarily reflect EPA or
EC policies or views.
NR 47
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U1 2
U2 17
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1680-7316
EI 1680-7324
J9 ATMOS CHEM PHYS
JI Atmos. Chem. Phys.
PY 2011
VL 11
IS 20
BP 10743
EP 10763
DI 10.5194/acp-11-10743-2011
PG 21
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 842IW
UT WOS:000296593000029
ER
PT J
AU Song, MO
Freedman, JH
AF Song, Min Ok
Freedman, Jonathan H.
TI Role of hepatocyte nuclear factor 4 alpha in controlling
copper-responsive transcription
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
LA English
DT Article
DE Copper; HNF4 alpha; HepG2 cell; Transcription; p53; Gene expression;
ATF3
ID GENE-EXPRESSION; WILSON-DISEASE; HEPG2 CELLS; DNA-BINDING; METAL-IONS;
P53; TOXICITY; FACTOR-4-ALPHA; HOMEOSTASIS; MECHANISMS
AB Previous global transcriptome and interactome analyses of copper-treated HepG2 cells identified hepatocyte nuclear factor 4 alpha (HNF4 alpha) as a potential master regulator of copper-responsive transcription. Copper exposure caused a decrease in the expression of HNF4 alpha at both mRNA and protein levels, which was accompanied by a decrease in the level of HNF4 alpha binding to its consensus DNA binding sequence. qRT-PCR and RNAi studies demonstrated that changes in HNF4 alpha expression ultimately affected the expressions of its down-stream target genes. Analysis of upstream regulators of HNF4 alpha expression, including p53 and ATF3, showed that copper caused an increase in the steady-state levels of these proteins. These results support a model for copper-responsive transcription in which the metal affects ATF3 expression and stabilizes p53 resulting in the down-regulation of HNF4 alpha expression. In addition, copper may directly affect p53 protein levels. The suppression of HNF4 alpha activity may contribute to the molecular mechanisms underlying the physiological and toxicological consequences of copper toxicity in hepatic-derived cells. Published by Elsevier B.V.
C1 [Song, Min Ok; Freedman, Jonathan H.] Natl Inst Environm Hlth Sci, Lab Toxicol & Pharmacol, Res Triangle Pk, NC 27709 USA.
RP Freedman, JH (reprint author), Natl Inst Environm Hlth Sci, Lab Toxicol & Pharmacol, Mail Drop E1-05,POB 12233,111 TW Alexander Dr, Res Triangle Pk, NC 27709 USA.
EM freedma1@niehs.nih.gov
FU NIH; NIEHS [Z01ES102045]
FX This work was supported (in part) by the Intramural Research Program of
the NIH and NIEHS (Z01ES102045).
NR 48
TC 6
Z9 6
U1 0
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-4889
J9 BBA-MOL CELL RES
JI Biochim. Biophys. Acta-Mol. Cell Res.
PD JAN
PY 2011
VL 1813
IS 1
BP 102
EP 108
DI 10.1016/j.bbamcr.2010.09.009
PG 7
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 715GC
UT WOS:000286867800010
PM 20875833
ER
PT J
AU Wehby, GL
Fletcher, JM
Lehrer, SF
Moreno, LM
Murray, JC
Wilcox, A
Lie, RT
AF Wehby, George L.
Fletcher, Jason M.
Lehrer, Steven F.
Moreno, Lina M.
Murray, Jeffrey C.
Wilcox, Allen
Lie, Rolv T.
TI A Genetic Instrumental Variables Analysis of the Effects of Prenatal
Smoking on Birth Weight: Evidence from Two Samples
SO BIODEMOGRAPHY AND SOCIAL BIOLOGY
LA English
DT Article
ID MATERNAL SMOKING; NICOTINE DEPENDENCE; WEAK INSTRUMENTS; UNITED-STATES;
TOBACCO USE; MENDELIAN RANDOMIZATION; ORAL CLEFTS; PREGNANCY;
ASSOCIATION; CHILDREN
AB There is a large literature showing the detrimental effects of prenatal smoking on birth and childhood health outcomes. It is somewhat unclear, though, whether these effects are causal or reflect other characteristics and choices by mothers who choose to smoke that may also affect child health outcomes or biased reporting of smoking. In this paper, we use genetic markers that predict smoking behaviors as instruments to address the endogeneity of smoking choices in the production of birth and childhood health outcomes. Our results indicate that prenatal smoking produces more dramatic declines in birth weight than estimates that ignore the endogeneity of prenatal smoking, which is consistent with previous studies with non-genetic instruments. We use data from two distinct samples from Norway and the United States with different measured instruments and find nearly identical results. The study provides a novel application that can be extended to study several behavioral impacts on health and social and economic outcomes.
C1 [Wehby, George L.] Univ Iowa, Dept Hlth Management & Policy, Coll Publ Hlth, Iowa City, IA 52242 USA.
[Fletcher, Jason M.] Yale Univ, Dept Epidemiol & Publ Hlth, Div Hlth Policy & Adm, New Haven, CT 06520 USA.
[Lehrer, Steven F.] Queens Univ, Sch Policy Studies, Kingston, ON, Canada.
[Moreno, Lina M.] Univ Iowa, Dept Orthodont, Dows Inst, Iowa City, IA 52242 USA.
[Murray, Jeffrey C.] Univ Iowa, Dept Pediat, Iowa City, IA 52242 USA.
[Wilcox, Allen] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
[Lie, Rolv T.] Univ Bergen, Sect Med Stat, Bergen, Norway.
RP Wehby, GL (reprint author), Univ Iowa, Dept Hlth Management & Policy, Coll Publ Hlth, 200 Hawkins Dr,E205 GH, Iowa City, IA 52242 USA.
EM george-wehby@uiowa.edu; jason.fletcher@yale.edu
OI Wilcox, Allen/0000-0002-3376-1311
FU Intramural NIH HHS; NICHD NIH HHS [P01-HD31921, P01 HD031921]; NIDCR NIH
HHS [R03 DE018394, R01 DE020895-01, R01 DE020895, R03 DE018394-02, 1 R01
DE020895-01, 1 R03 DE018394]
NR 73
TC 10
Z9 10
U1 2
U2 9
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1948-5565
J9 BIODEMOGR SOC BIOL
JI Biodemography Soc. Biol.
PY 2011
VL 57
IS 1
SI SI
BP 3
EP 32
AR PII 937662953
DI 10.1080/19485565.2011.564468
PG 30
WC Demography; Social Sciences, Biomedical; Sociology
SC Demography; Biomedical Social Sciences; Sociology
GA 765BX
UT WOS:000290679500002
PM 21845925
ER
PT J
AU Domingo, JWS
Revetta, RP
Iker, B
Gomez-Alvarez, V
Garcia, J
Sullivan, J
Weast, J
AF Domingo, Jorge W. Santo
Revetta, Randy P.
Iker, Brandon
Gomez-Alvarez, Vicente
Garcia, Jarissa
Sullivan, John
Weast, James
TI Molecular survey of concrete sewer biofilm microbial communities
SO BIOFOULING
LA English
DT Article
DE concrete biofilm; SSU rDNA sequences; microbial diversity
ID 16S RIBOSOMAL-RNA; ENVIRONMENTAL-SAMPLES; BACTERIAL COMMUNITY; OXIDIZING
BACTERIA; SP NOV.; GENE; DIVERSITY; PHYLOGENY; SEQUENCES; OXIDATION
AB The microbial composition of concrete biofilms within wastewater collection systems was studied using molecular assays. SSU rDNA clone libraries were generated from 16 concrete surfaces of manholes, a combined sewer overflow, and sections of a corroded sewer pipe. Of the 2457 sequences analyzed, alpha-, beta-, gamma-, and delta-Proteobacteria represented 15%, 22%, 11%, and 4% of the clones, respectively. beta-Proteobacteria (47%) sequences were more abundant in the pipe crown than any of the other concrete surfaces. While 178 to 493 Operational Taxonomic Units (OTUs) were associated with the different concrete samples, only four sequences were shared among the different clone libraries. Bacteria implicated in concrete corrosion were found in the clone libraries while archaea, fungi, and several bacterial groups were also detected using group-specific assays. The results showed that concrete sewer biofilms are more diverse than previously reported. A more comprehensive molecular database will be needed to better study the dynamics of concrete biofilms.
C1 [Domingo, Jorge W. Santo; Revetta, Randy P.; Iker, Brandon; Gomez-Alvarez, Vicente] Environm Protect Agcy, Cincinnati, OH USA.
[Garcia, Jarissa; Sullivan, John; Weast, James] Metropolitan Sewer Dist Greater Cincinnati, Cincinnati, OH USA.
RP Domingo, JWS (reprint author), Environm Protect Agcy, Cincinnati, OH USA.
EM santodomingo.jorge@epa.gov
FU EPA; US Environmental Protection Agency through Office of Research and
Development
FX This research was funded in part by EPA's Aging Water Infrastructure
Research Program. The US Environmental Protection Agency, through its
Office of Research and Development, funded and managed the research
described herein. It has been subjected to the Agency's administrative
review and has been approved for external publication. Any opinions
expressed in this article are those of the author(s) and do not
necessarily reflect the views of the Agency, therefore, no official
endorsement should be inferred. Any mention of trade names or commercial
products does not constitute endorsement or recommendation for use. Mr
Biju George and Ms Beverly Head are acknowledged for valuable
discussions and suggestions during the planning process, and for
unlimited access to staff and facilities.
NR 38
TC 14
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U1 1
U2 23
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0892-7014
J9 BIOFOULING
JI Biofouling
PY 2011
VL 27
IS 9
BP 993
EP 1001
DI 10.1080/08927014.2011.618637
PG 9
WC Biotechnology & Applied Microbiology; Marine & Freshwater Biology
SC Biotechnology & Applied Microbiology; Marine & Freshwater Biology
GA 844BQ
UT WOS:000296722800005
ER
PT J
AU Niinemets, U
Kuhn, U
Harley, PC
Staudt, M
Arneth, A
Cescatti, A
Ciccioli, P
Copolovici, L
Geron, C
Guenther, A
Kesselmeier, J
Lerdau, MT
Monson, RK
Penuelas, J
AF Niinemets, Ue.
Kuhn, U.
Harley, P. C.
Staudt, M.
Arneth, A.
Cescatti, A.
Ciccioli, P.
Copolovici, L.
Geron, C.
Guenther, A.
Kesselmeier, J.
Lerdau, M. T.
Monson, R. K.
Penuelas, J.
TI Estimations of isoprenoid emission capacity from enclosure studies:
measurements, data processing, quality and standardized measurement
protocols
SO BIOGEOSCIENCES
LA English
DT Article
ID VOLATILE ORGANIC-COMPOUNDS; CHROMATOGRAPHY-MASS-SPECTROMETRY;
PHOTOSYNTHETICALLY ACTIVE RADIATION; BIOGENIC HYDROCARBON EMISSIONS;
RESOLUTION GAS-CHROMATOGRAPHY; ATMOSPHERIC CO2 CONCENTRATION; MULTIPOINT
MEASURING SYSTEM; LOW-DENSITY POLYETHYLENE; ASPEN POPULUS-TREMULA;
QUERCUS-ILEX LEAVES
AB The capacity for volatile isoprenoid production under standardized environmental conditions at a certain time (E-S, the emission factor) is a key characteristic in constructing isoprenoid emission inventories. However, there is large variation in published E-S estimates for any given species partly driven by dynamic modifications in E-S due to acclimation and stress responses. Here we review additional sources of variation in E-S estimates that are due to measurement and analytical techniques and calculation and averaging procedures, and demonstrate that estimations of E-S critically depend on applied experimental protocols and on data processing and reporting. A great variety of experimental setups has been used in the past, contributing to study-to-study variations in E-S estimates. We suggest that past experimental data should be distributed into broad quality classes depending on whether the data can or cannot be considered quantitative based on rigorous experimental standards. Apart from analytical issues, the accuracy of E-S values is strongly driven by extrapolation and integration errors introduced during data processing. Additional sources of error, especially in meta-database construction, can further arise from inconsistent use of units and expression bases of E-S. We propose a standardized experimental protocol for BVOC estimations and highlight basic meta-information that we strongly recommend to report with any E-S measurement. We conclude that standardization of experimental and calculation protocols and critical examination of past reports is essential for development of accurate emission factor databases.
C1 [Niinemets, Ue.; Copolovici, L.] Estonian Univ Life Sci, Inst Agr & Environm Sci, EE-51014 Tartu, Estonia.
[Kuhn, U.] Forschungszentrum Julich, Inst Energie & Klimaforsch Troposphare IEK 8, D-52425 Julich, Germany.
[Harley, P. C.; Guenther, A.] Natl Ctr Atmospher Res, Boulder, CO 80307 USA.
[Staudt, M.] Ctr Ecol Fonct & Evolut CEFE CNRS, F-34293 Montpellier 5, France.
[Arneth, A.] Lund Univ, Div Phys Geog & Ecosyst Anal, S-22362 Lund, Sweden.
[Arneth, A.] Karlsruhe Inst Technol, Inst Meteorol & Climate Atmospher Environm Res, D-82467 Garmisch Partenkirchen, Germany.
[Cescatti, A.] Commiss European Communities, Joint Res Ctr, Inst Environm & Sustainabil, I-21020 Ispra, Italy.
[Ciccioli, P.] CNR, Ist Metodol Chim, Area Ric Roma 1, I-00016 Monterotondo, Italy.
[Geron, C.] US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
[Kesselmeier, J.] Max Planck Inst Chem, Biogeochem Dept, D-55020 Mainz, Germany.
[Lerdau, M. T.] Univ Virginia, Dept Environm Sci, Charlottesville, VA 22904 USA.
[Lerdau, M. T.] Xishuangbanna Trop Bot Garden, Melung, Yunnan, Peoples R China.
[Monson, R. K.] Univ Colorado, Dept Ecol & Evolutionary Biol, Boulder, CO 80309 USA.
[Monson, R. K.] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA.
[Penuelas, J.] Univ Autonoma Barcelona, Fac Ciencies, Global Ecol Unit, CSIC CEAB CREAF, Bellaterra 08193, Spain.
RP Niinemets, U (reprint author), Estonian Univ Life Sci, Inst Agr & Environm Sci, Kreutzwaldi 1, EE-51014 Tartu, Estonia.
EM ylo.niinemets@emu.ee
RI Guenther, Alex/B-1617-2008; Kesselmeier, Jurgen/E-2389-2016; Niinemets,
Ulo/A-3816-2008; Arneth, Almut/B-2702-2013; Penuelas, Josep/D-9704-2011;
Copolovici, Lucian/B-6552-2011; Kuhn, Uwe/C-4830-2013; Harley,
Peter/E-1856-2014; Garmisch-Pa, Ifu/H-9902-2014;
OI Guenther, Alex/0000-0001-6283-8288; Kesselmeier,
Jurgen/0000-0002-4446-534X; Niinemets, Ulo/0000-0002-3078-2192;
Penuelas, Josep/0000-0002-7215-0150; Copolovici,
Lucian/0000-0002-4454-200X; Harley, Peter/0000-0002-2647-1973; Staudt,
Michael/0000-0001-8694-507X
FU Estonian Ministry of Science and Education [SF1090065s07]; Estonian
Science Foundation [7645]; European Commission; US National Science
Foundation; US Environmental Protection Agency; Spanish Ministry of
Science [CGL2006-04025/BOS, CSD2008-00040]; Catalan Department of
Science [SGR 2009-458]; Max Planck Society; Human Frontier Science
Program
FX We thank the European Science Foundation (VOCBAS and INTROP programs)
for travel support. The authors' studies on BVOCs have been funded by
the Estonian Ministry of Science and Education (grant SF1090065s07), the
Estonian Science Foundation (grant 7645), European Commission through
European Regional Fund (the Center of Excellence in Environmental
Adaptation), the US National Science Foundation and the US Environmental
Protection Agency, the Spanish Ministry of Science (grants
CGL2006-04025/BOS and Consolider-Ingenio Montes CSD2008-00040), the
Catalan Department of Science (grant SGR 2009-458), and the Max Planck
Society. U. N., A. A., and R. K. M. acknowledge support from the Human
Frontier Science Program.
NR 278
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Z9 54
U1 4
U2 41
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1726-4170
EI 1726-4189
J9 BIOGEOSCIENCES
JI Biogeosciences
PY 2011
VL 8
IS 8
BP 2209
EP 2246
DI 10.5194/bg-8-2209-2011
PG 38
WC Ecology; Geosciences, Multidisciplinary
SC Environmental Sciences & Ecology; Geology
GA 814MA
UT WOS:000294457100014
ER
PT J
AU Ritter, W
Andersen, CP
Matyssek, R
Grams, TEE
AF Ritter, W.
Andersen, C. P.
Matyssek, R.
Grams, T. E. E.
TI Carbon flux to woody tissues in a beech/spruce forest during summer and
in response to chronic O-3 exposure
SO BIOGEOSCIENCES
LA English
DT Article
ID BEECH FAGUS-SYLVATICA; FREE-AIR FUMIGATION; LOW OZONE CONCENTRATIONS;
BIRCH BETULA-PENDULA; PICEA-ABIES TREES; ISOTOPE COMPOSITION; CO2
EFFLUX; MATURE TREES; ELEVATED CO2; TROPOSPHERIC OZONE
AB The present study compares the dynamics in carbon (C) allocation of adult deciduous beech (Fagus sylvatica) and evergreen spruce (Picea abies) during summer and in response to seven-year-long exposure with twice-ambient ozone (O-3) concentrations (2xO(3)). Focus was on the respiratory turn-over and translocation of recent photosynthates at various positions along the stems, coarse roots and soils. The hypotheses tested were that (1) 2xO(3) decreases the allocation of recent photosynthates to CO2 efflux of stems and coarse roots of adult trees, and that (2) according to their different O3 sensitivities this effect is stronger in beech than in spruce.
Labeling of whole tree canopies was applied by releasing C-13 depleted CO2 (delta C-13 of -46.9 %) using a free-air stable carbon isotope approach. Canopy air delta C-13 was reduced for about 2.5 weeks by ca. 8 parts per thousand in beech and 6 parts per thousand in spruce while the increase in CO2 concentration was limited to about 110 mu l l(-1) and 80 mu l l(-1), respectively. At the end of the labeling period, delta C-13 of stem CO2 efflux and phloem sugars was reduced to a similar extend by ca. 3-4% (beech) and ca. 23%( spruce). The fraction of labeled C (f(E,) (new)) in stem CO2 efflux amounted to 0.3 to 0.4, indicating slow C turnover of the respiratory supply system in both species.
Elevated O-3 slightly stimulated the allocation of recently fixed photosynthates to stem and coarse root respiration in spruce (rejection of hypothesis I for spruce), but resulted in a significant reduction in C flux in beech (acceptance of hypotheses I and II). The distinct decrease in C allocation to beech stems indicates the potential of chronic O3 stress to substantially mitigate the C sink strength of trees on the long-term scale.
C1 [Ritter, W.; Matyssek, R.; Grams, T. E. E.] Tech Univ Munich, Dept Ecol & Ecosyst Management, D-85354 Freising Weihenstephan, Germany.
[Andersen, C. P.] US EPA, Western Ecol Div, Corvallis, OR 97333 USA.
RP Grams, TEE (reprint author), Tech Univ Munich, Dept Ecol & Ecosyst Management, Hans Carl von Carlowitz Pl 2, D-85354 Freising Weihenstephan, Germany.
EM grams@tum.de
FU SFB [607]; Agronomy and Forestry; Deutsche Forschungsgemeinschaft" (DFG)
[B5]
FX We gratefully acknowledge the skillful assistance of T. Feuerbach, H.
Lohner, P. Kuba, and J. Heckmair. The study was funded through SFB 607
"Growth and Parasite Defense-Competition for Resources in Economic
Plants from Agronomy and Forestry, Projects B5" by the "Deutsche
Forschungsgemeinschaft" (DFG). The authors also wish to thank B.
Ozretich and A. Bytnerowicz for helpful comments on an earlier version
of the manuscript. The information in this paper has been subjected to
EPA peer and administrative review, and it has been approved for
publication as an EPA document. Mention of trade names or commercial
products does not constitute endorsement or recommendation for use.
NR 74
TC 5
Z9 5
U1 3
U2 18
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1726-4170
J9 BIOGEOSCIENCES
JI Biogeosciences
PY 2011
VL 8
IS 11
BP 3127
EP 3138
DI 10.5194/bg-8-3127-2011
PG 12
WC Ecology; Geosciences, Multidisciplinary
SC Environmental Sciences & Ecology; Geology
GA 862ZI
UT WOS:000298132200002
ER
PT J
AU Maynard, JJ
Dahlgren, RA
O'Geen, AT
AF Maynard, J. J.
Dahlgren, R. A.
O'Geen, A. T.
TI Soil carbon cycling and sequestration in a seasonally saturated wetland
receiving agricultural runoff
SO BIOGEOSCIENCES
LA English
DT Article
ID FRESH-WATER WETLANDS; CONTERMINOUS UNITED-STATES; SAN-JOAQUIN VALLEY;
CONSTRUCTED WETLANDS; ORGANIC-MATTER; NUTRIENT ACCUMULATION;
CLIMATE-CHANGE; EROSION; SEDIMENT; TERRESTRIAL
AB The fate of organic carbon (C) lost by erosion is not well understood in agricultural settings. Recent models suggest that wetlands and other small water bodies may serve as important long-term sinks of eroded C, receiving similar to 30% of all eroded material in the US. To better understand the role of seasonally-saturated wetlands in sequestering eroded C, we examined the spatial and temporal dynamics of C and sediment accumulation in a 13-year-old constructed wetland used to treat agricultural runoff. The fate of C sequestered within deposited sediment was modeled using point-sampling, remote sensing, and geostatistics. Using a spatially-explicit sampling design, annual net rates of sedimentation and above-ground biomass were measured during two contrasting years (vegetated (2004) vs. non-vegetated (2005)), followed by collection of sediment cores to the antecedent soil layer, representing 13 years of sediment and C accumulation. We documented high annual variation in the relative contribution of endogenous and exogenous C sources, as well as absolute rates of sediment and C deposition. This annual variation, however, was muted in the long-term (13 yr) sediment record, which showed consistent vertical patterns of uniform C distribution (similar to 14 g kg(-1)) and delta C-13 signatures in high depositional environments. This was in contrast to low depositional environments which had high levels of surface C enrichment (20-35 g kg(-1)) underlain by C depleted (5-10 g kg(-1)) sediments and an increasing delta C-13 signature with depth indicating increased decomposition. These results highlight the importance of sedimentation in physically protecting soil organic carbon and its role in controlling the long-term C concentration of seasonally-saturated wetland soils. While significant enrichment of surface sediments with endogenous C occurred in newly deposited sediment (i.e., 125 kgm(2) in 2004), fluctuating cycles of flooding and drying maintained the long-term C concentration at the same level as inflowing sediment (i.e., 14 g kg(-1)), indicating no additional long-term storage of endogenous C. These results demonstrate that constructed flow-through wetlands can serve as important sinks for eroded C and sediment in agricultural landscapes, however, additional C sequestration via enrichment from endogenous sources may be limited in seasonally-saturated wetlands due to rapid decomposition during drying cycles.
C1 [Maynard, J. J.] US EPA, Corvallis, OR USA.
[Dahlgren, R. A.; O'Geen, A. T.] Univ Calif Davis, Dept Land Air & Water Resources, Davis, CA 95616 USA.
RP Maynard, JJ (reprint author), US EPA, Corvallis, OR USA.
EM maynard.jonathan@epa.gov
FU California State Water Resources Control Board; Kearney Foundation of
Soil Science
FX Funding for this project has been provided through an agreement with the
California State Water Resources Control Board and the Kearney
Foundation of Soil Science. The contents of this document do not
necessarily reflect the views and policies of the California State Water
Resources Control Board, nor does mention of trade names or commercial
products constitute endorsement or recommendation for use. The
information in this document has been subjected to review by the
National Health and Environmental Effects Research Laboratory's Western
Ecology Division and approved for publication. Approval does not signify
that the contents reflect the views of the Agency, nor does mention of
trade names or commercial products constitute endorsement or
recommendation for use. We would like to thank Mickey Saso for his
cooperation and support, and Jiayou Deng and James Chang for their help
with field sampling and laboratory analysis. We would also like to thank
Greg McCarty, William Renwick, and an anonymous referee for their
constructive review of this manuscript.
NR 77
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Z9 5
U1 3
U2 38
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1726-4170
J9 BIOGEOSCIENCES
JI Biogeosciences
PY 2011
VL 8
IS 11
BP 3391
EP 3406
DI 10.5194/bg-8-3391-2011
PG 16
WC Ecology; Geosciences, Multidisciplinary
SC Environmental Sciences & Ecology; Geology
GA 862ZI
UT WOS:000298132200019
ER
PT J
AU Rao, ST
Galmarini, S
Puckett, K
AF Rao, S. Trivikrama
Galmarini, Stefano
Puckett, Keith
TI Air Quality Model Evaluation International Initiative (AQMEII) Advancing
the State of the Science in Regional Photochemical Modeling and Its
Applications
SO BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY
LA English
DT Editorial Material
ID MULTIMODEL ENSEMBLE; AMS WORKSHOP; WOODS-HOLE; PART I; VERSION 4.5;
PERFORMANCE; OZONE; PREDICTIONS; FORECASTS; UNCERTAINTY
C1 [Rao, S. Trivikrama] US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Galmarini, Stefano] Commiss European Communities, Joint Res Ctr, Inst Environm & Sustainabil, I-21020 Ispra, Italy.
[Puckett, Keith] Environm Canada, Air Qual Res Div, Toronto, ON, Canada.
RP Rao, ST (reprint author), US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
EM rao.st@epa.gov
NR 48
TC 62
Z9 63
U1 0
U2 18
PU AMER METEOROLOGICAL SOC
PI BOSTON
PA 45 BEACON ST, BOSTON, MA 02108-3693 USA
SN 0003-0007
EI 1520-0477
J9 B AM METEOROL SOC
JI Bull. Amer. Meteorol. Soc.
PD JAN
PY 2011
VL 92
IS 1
BP 23
EP 30
DI 10.1175/2010BAMS3069.1
PG 8
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 729OD
UT WOS:000287959200009
ER
PT J
AU Sielen, AB
AF Sielen, Alan B.
TI "WE DYE FOR THE STARS" Los Angeles Remembered
SO CALIFORNIA HISTORY
LA English
DT Article
C1 [Sielen, Alan B.] US EPA, Washington, DC USA.
RP Sielen, AB (reprint author), Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biodivers & Conservat, San Diego, CA 92103 USA.
NR 6
TC 0
Z9 0
U1 0
U2 0
PU CALIFORNIA HISTORICAL SOC
PI SAN FRANCISCO
PA 678 MISSION ST, SAN FRANCISCO, CA 94105-4014 USA
SN 0162-2897
J9 CALIF HIST
JI Calif. Hist.
PY 2011
VL 88
IS 3
BP 40
EP +
PG 24
WC History
SC History
GA V32JY
UT WOS:000208948700006
ER
PT J
AU Virkutyte, J
Varma, RS
AF Virkutyte, Jurate
Varma, Rajender S.
TI Green synthesis of metal nanoparticles: Biodegradable polymers and
enzymes in stabilization and surface functionalization
SO CHEMICAL SCIENCE
LA English
DT Article
ID COATED GOLD NANOPARTICLES; IRON-OXIDE NANOPARTICLES; SILVER
NANOPARTICLES; PALLADIUM NANOPARTICLES; MAGNETIC NANOPARTICLES;
CARBOXYMETHYL CELLULOSE; CHITOSAN NANOCOMPOSITES; BIOLOGICAL
APPLICATIONS; RECYCLABLE CATALYST; POLYETHYLENE-GLYCOL
AB Current breakthroughs in green nanotechnology are capable of transforming many of the existing processes and products that enhance environmental quality, reduce pollution, and conserve natural and non-renewable resources. Successful use of metal nanoparticles and nanocomposites in various catalytic applications, electronics, biology and biomedical applications, material science, physics, environmental remediation and interdisciplinary fields as well as their toxicity essentially depends on the structural features such as size, shape, composition and the surface chemistry of nanomaterials. Moreover, to prolong the life span of metal nanoparticles and avoid undesired effects such as aggregation in aqueous solutions and organic solvents, to prevent contamination of the environment as well as to reuse and recycle nanoparticles, it is vital to select stabilizing agents and functionalization pathways that are environmentally friendly, non toxic and easy to implement. In recent years, stabilization and surface functionalization of metal nanoparticles became 'greener' to the extent that biocompatible stabilizing agents, e. g. biodegradable polymers and enzymes among others were introduced. These agents were able to produce a great variety of extremely stable spherical-, rod- or flower- shaped metal nanoparticles that opened up vast opportunities for their utilization and potential mass production. This review summarizes the state-of-the-art in the use of biocompatible and biodegradable homo- and copolymers as well as enzymes for the production of stable, environmentally benign, selective and active metal nanoparticles for desired applications.
C1 [Virkutyte, Jurate; Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Virkutyte, J (reprint author), Pegasus Tech Serv Inc, 46 E Hollister St, Cincinnati, OH 45219 USA.
EM Virkutyte.Jurate@epa.gov; Varma.Rajender@epa.gov
FU US EPA
FX This work was accomplished while J.V. held a National Research Council
Research Associateship Award at US EPA.
NR 79
TC 106
Z9 107
U1 5
U2 103
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2041-6520
J9 CHEM SCI
JI Chem. Sci.
PY 2011
VL 2
IS 5
BP 837
EP 846
DI 10.1039/c0sc00338g
PG 10
WC Chemistry, Multidisciplinary
SC Chemistry
GA 764KY
UT WOS:000290629600001
ER
PT J
AU Loux, NT
AF Loux, Nicholas T.
TI Extending the diffuse layer model of surface acidity constant behaviour:
IV. Diffuse layer charge/potential relationships
SO CHEMICAL SPECIATION AND BIOAVAILABILITY
LA English
DT Article
DE charge/potential relationships; Poisson-Boltzmann equation; hypernetted
chain; Entropic Balanced Surface Potential model; diffuse layer
potential
ID POISSON-BOLTZMANN EQUATION; ELECTRICAL DOUBLE-LAYERS; OXIDE-WATER
INTERFACE; COUNTERION CONDENSATION; ACTIVITY-COEFFICIENTS; FREE-ENERGY;
ADSORPTION; HYDRATION; IONS; PARTICLE
AB Most current electrostatic surface complexation models describing ionic binding at the particle/water interface rely on the use of Poisson-Boltzmann (PB) theory for relating diffuse layer charge densities to diffuse layer electrostatic potentials. PB theory is known to contain a number of implicit assumptions whose significance in environmental applications is largely unknown. This study seeks to better quantify the impact of these assumptions by: (1) comparing potentials obtained from planar analytical solutions to the PB with those obtained from Hypernetted Chain (HNC) theory (Attard, 2006), (2) assessing the accuracy of the Ohshima et al. (1982) spherical approximate analytical solution to the PB equation by comparison with published numerical values (Loeb et al., 1961), and (3) comparing interfacial potential estimates obtained from the spherical approximate analytical solution to the PB equation at and adjacent to the particle surface with potential estimates obtained from the Entropic Balanced Surface Potential (EB) model (Loux, 1985; Loux and Anderson, 2001) and published potential estimates obtained from the Hypernetted Chain/Mean Spherical Approximation procedure (HNC/MSA; Gonzalez-Tovar and Lozada-Cassou, 1989). EB potential estimates were obtained assuming a surface volume thickness equal to the Bjerrum length (0.357 nm in a room temperature monovalent electrolyte solution). Findings from the study included: (1) the planar, surficial HNC estimates compared favourably with planar surficial PB relationships at charge densities equal to or less than 0.05C m(-2), (2) the Ohshima et al. (1982) approximate spherical analytical solution to the PB equation replicated the numerical charge density estimates required to obtain 72 datapoints over an e Psi/kT range of one to four with a maximum error of 3.37% and a coefficient of variation of 0.92%, (3) for a 0.1 mu m radius particle in a room temperature 0.01 M (1:1) ionic strength solution, potential estimates over a surface charge density range of 0 to 0.3C m(-2) occurred in the following order: Psi(HNC/MSA,R) > Psi(PB,R) > Psi(HNC/MSA,R+0.2125) (nm) > Psi P-B,P-R+0.2 nm similar to Psi(EB) > Psi(HNC/MSA,R+0.425 nm) similar to Psi(PB,R+0.4 nm) and (4) with 45 datapoints including both 1 mu m and 10 nm radius particles over an ionic strength range of 1.0 to 0.001 M, the PB potential estimates 0.2 nm from the particle surface (Psi(PB,R+0.2 nm)) closely tracked the corresponding EB estimates (Psi(EB)) with a 5.3% coefficient of variation. If one assumes that interfacial potential values adjacent to the particle surface are most relevant for describing environmental phenomena and that a 10% coefficient of variation in potential estimates is acceptable, then presumably any of the non-surficial charge/potential relationships would be useful below an absolute charge density of 0.125 C m(-2) (with monovalent electrolyte solutions).
C1 US EPA, EPA ORD NERL ERD, Athens, GA 30605 USA.
RP Loux, NT (reprint author), US EPA, EPA ORD NERL ERD, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM loux.nick@epa.gov
FU United States Environmental Protection Agency through its Office of
Research and Development
FX The United States Environmental Protection Agency through its Office of
Research and Development funded and managed the research described here.
It has been subjected to the agency's administrative review process and
approved for publication. Mention of trade names and commercial products
does not necessarily constitute recommendation for use.
NR 57
TC 0
Z9 0
U1 1
U2 5
PU SCIENCE REVIEWS 2000 LTD
PI ST ALBANS
PA PO BOX 314, ST ALBANS AL1 4ZG, HERTS, ENGLAND
SN 0954-2299
J9 CHEM SPEC BIOAVAILAB
JI Chem. Speciation Bioavail.
PY 2011
VL 23
IS 4
BP 213
EP 223
DI 10.3184/095422911X13103739560379
PG 11
WC Biochemistry & Molecular Biology; Environmental Sciences; Toxicology
SC Biochemistry & Molecular Biology; Environmental Sciences & Ecology;
Toxicology
GA 858TC
UT WOS:000297824600003
ER
PT J
AU Silva, MJ
Furr, J
Samandar, E
Preau, JL
Gray, LE
Needham, LL
Calafat, AM
AF Silva, Manori J.
Furr, Johnathan
Samandar, Ella
Preau, James L., Jr.
Gray, L. Earl
Needham, Larry L.
Calafat, Antonia M.
TI Urinary and serum metabolites of di-n-pentyl phthalate in rats
SO CHEMOSPHERE
LA English
DT Article
DE Di-n-pentyl phthalate (DPP); Mono-n-pentyl phthalate (MPP); MHPP;
Biomarkers; Exposure assessment; Oxidative metabolism
ID DEUTERIUM-LABELED DEHP; DI(2-ETHYLHEXYL)PHTHALATE DEHP; OXIDATIVE
METABOLITES; MASS-SPECTROMETRY; BUTYL PHTHALATE; OCTYL PHTHALATE; HUMAN
EXPOSURE; BIOMARKERS; ESTERS; EXCRETION
AB Di-n-pentyl phthalate (DPP) is used mainly as a plasticizer in nitrocellulose. At high doses. DPP acts as a potent testicular toxicant in rats. We administered a single oral dose of 500 mg kg(-1) bw of DPP to adult female Sprague-Dawley rats (N = 9) and collected 24-h urine samples 1 d before and 24- and 48-h after DPP was administered to tentatively identify DPP metabolites that could be used as exposure biomarkers. At necropsy, 48 h after dosing, we also collected serum. The metabolites were extracted from urine or serum, resolved with high performance liquid chromatography, and detected by mass spectrometry. Two DPP metabolites, phthalic acid (PA) and mono(3-carboxypropyl) phthalate (MCPP), were identified by using authentic standards, whereas mono-n-pentyl phthalate (MPP), mono(4-oxopentyl) phthalate (MOPP), mono(4-hydroxypentyl) phthalate (MHPP), mono(4-carboxybutyl) phthalate (MCBP), mono(2-carboxyethyl) phthalate (MCEP), and mono-n-pentenyl phthalate (MPeP) were identified based on their full scan mass spectrometric fragmentation pattern. The omega - 1 oxidation product, MHPP, was the predominant urinary metabolite of DPP. The median urinary concentrations (mu g mL(-1)) of the metabolites in the first 24 h urine collection after DPP administration were 993 (MHPP), 168 (MCBP), 0.2 (MCEP), 222 (MPP), 47 (MOPP), 26 (PA), 16 (MPeP), and 9 (MCPP): the concentrations of metabolites in the second 24 h urine collection after DPP administration were significantly lower than in the first collection. We identified some urinary metabolic products in the serum, but at much lower levels than in urine. Because of the similarities in metabolism of phthalates between rats and humans, based on our results and the fact that MHPP can only be formed from the metabolism of DPP, MHPP would be the most adequate DPP exposure biomarker for human exposure assessment. Nonetheless, based on the urinary levels of MHPP, our preliminary data suggest that human exposure to DPP in the United States is rather limited. Published by Elsevier Ltd.
C1 [Silva, Manori J.; Samandar, Ella; Preau, James L., Jr.; Needham, Larry L.; Calafat, Antonia M.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA.
[Furr, Johnathan; Gray, L. Earl] US EPA, Reprod Toxicol Branch, Toxic Assessment Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Res Triangle Pk, NC 27711 USA.
RP Silva, MJ (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway,Mailstop F53, Chamblee, GA 30341 USA.
EM zca2@cdc.gov
RI Needham, Larry/E-4930-2011
NR 29
TC 8
Z9 8
U1 5
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
J9 CHEMOSPHERE
JI Chemosphere
PD JAN
PY 2011
VL 82
IS 3
BP 431
EP 436
DI 10.1016/j.chemosphere.2010.09.052
PG 6
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 710EN
UT WOS:000286493800018
PM 20951405
ER
PT J
AU Zhang, XL
Yan, S
Tyagi, RD
Surampalli, RY
AF Zhang, Xiaolei
Yan, Song
Tyagi, R. D.
Surampalli, R. Y.
TI Synthesis of nanoparticles by microorganisms and their application in
enhancing microbiological reaction rates
SO CHEMOSPHERE
LA English
DT Review
DE Nanotechnology; Nanoparticles; Microorganisms; Nanoparticle
biosynthesis; Biosynthesis mechanism; Applications of nanoparticles
ID WASTE-WATER TREATMENT; ZERO-VALENT IRON; GOLD NANOPARTICLES;
EXTRACELLULAR BIOSYNTHESIS; FUNGUS; ACTINOMYCETE
AB Nanotechnology has attracted a great interest in recent years due to its expected impact on many areas such as energy, medicine, electronics, and space industries. This review provides the state-of-art knowledge on the synthesis of nanoparticles by microorganisms including bacteria, fungi, actinomycetes, and yeast, and their effect on microbiological processes. The available microbes and their predicted nanoparticle biosynthesis mechanism, the conditions to control the size/shape and monodispersity of particles, and microbiological reaction rate enhancement using nanoparticles as catalysts are presented. The current limitations and future scope for specific research are also discussed. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Zhang, Xiaolei; Yan, Song; Tyagi, R. D.] INRS Eau Terre & Environm, Quebec City, PQ G1K 9A9, Canada.
[Surampalli, R. Y.] US EPA, Kansas City, KS 66117 USA.
RP Tyagi, RD (reprint author), INRS Eau Terre & Environm, 490 Rue Couronne, Quebec City, PQ G1K 9A9, Canada.
EM tyagi@ete.inrs.ca
FU Natural Sciences and Engineering Research Council of Canada [A 4984]
FX Sincere thanks are due to the Natural Sciences and Engineering Research
Council of Canada (Grant A 4984, Canada Research Chair) for their
financial support. The authors thank Neema P.M. for reading the
manuscript. The views and opinions expressed in this paper are those of
the authors and should not be construed as the opinions of the US
Environmental Protection Agency.
NR 48
TC 73
Z9 74
U1 9
U2 63
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
J9 CHEMOSPHERE
JI Chemosphere
PD JAN
PY 2011
VL 82
IS 4
BP 489
EP 494
DI 10.1016/j.chemosphere.2010.10.023
PG 6
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 714DS
UT WOS:000286788300001
PM 21055786
ER
PT J
AU Smuleac, V
Varma, R
Baruwati, B
Sikdar, S
Bhattacharyya, D
AF Smuleac, Vasile
Varma, Rajender
Baruwati, Babita
Sikdar, Subhas
Bhattacharyya, Dibakar
TI Nanostructured Membranes for Enzyme Catalysis and Green Synthesis of
Nanoparticles
SO CHEMSUSCHEM
LA English
DT Article
DE electrostatic interactions; enzymes; immobilization; membranes;
nanoparticles
ID MICROFILTRATION MEMBRANES; NANOTUBE MEMBRANES; PD NANOPARTICLES;
HYDRODECHLORINATION; SELECTIVITY; DECHLORINATION; NANOCOMPOSITE;
CHANNEL; REACTOR; SIZE
AB Macroporous membranes functionalized with ionizable macromolecules provide promising applications in high capacity toxic metal capture, nanoparticle syntheses, and catalysis. Our low-pressure membrane approach has good reaction and separation selectivities, which are tunable by varying pH, ionic strength, or pressure. The sustainable green chemistry approach under ambient conditions and the evaluation of a reactive poly(acrylic acid) (PAA)-modified polyvinylidene fluoride (PVDF) membrane is described. Two distinct membrane types were obtained through different methods: 1) a stacked membrane through layer-by-layer assembly for the incorporation of enzymes (catalase and glucose oxidase), providing tunable product yields and 2) Fe/Pd nanoparticles for degradation of pollutants, obtained through an in situ green synthesis. Bioreactornanodomain interactions and mixed matrix nanocomposite membranes provide remarkable versatility compared to conventional membranes.
C1 [Smuleac, Vasile; Bhattacharyya, Dibakar] Univ Kentucky, Dept Chem & Mat Engn, Lexington, KY 40506 USA.
[Varma, Rajender; Baruwati, Babita; Sikdar, Subhas] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Bhattacharyya, D (reprint author), Univ Kentucky, Dept Chem & Mat Engn, Lexington, KY 40506 USA.
EM db@engr.uky.edu
FU NIEHS; DOE-KRCEE
FX This study was supported by the NIEHS-SRP program and by DOE-KRCEE.
NR 40
TC 7
Z9 7
U1 1
U2 22
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1864-5631
J9 CHEMSUSCHEM
JI ChemSusChem
PY 2011
VL 4
IS 12
BP 1773
EP 1777
DI 10.1002/cssc.201100211
PG 5
WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY
SC Chemistry; Science & Technology - Other Topics
GA 860MW
UT WOS:000297953400011
PM 22086852
ER
PT S
AU Garrison, AW
AF Garrison, A. Wayne
BE Garrison, AW
Gan, J
Liu, W
TI An Introduction to Pesticide Chirality and the Consequences of
Stereoselectivity
SO CHIRAL PESTICIDES: STEREOSELECTIVITY AND ITS CONSEQUENCES
SE ACS Symposium Series
LA English
DT Proceedings Paper
CT Symposium on Modern Chiral Pesticides: Enantioselectivity and Its
Consequences
CY 2010
CL San Francisco, CA
SP ACS, Agrochem Div
ID TRANSFORMATION; POLLUTANTS; TOXICITY
AB Thirty percent of known registered pesticides are chiral and usually exhibit some degree of stereoselectivity in their biodegradation rates and/or toxicity. Since the great majority of chiral pesticides are manufactured and applied as their racemic mixtures, there is a need for defining their stereoselectivity to provide for improved risk assessment and establish, in some cases, the rationale for production of single-or enriched-enantiomer products.
C1 US EPA, Natl Exposure Res Lab, Ecosyst Res Div, Athens, GA 30605 USA.
RP Garrison, AW (reprint author), US EPA, Natl Exposure Res Lab, Ecosyst Res Div, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM garrison.wayne@epa.gov
RI Liu, Weiping/E-9208-2010
OI Liu, Weiping/0000-0002-1173-892X
NR 16
TC 11
Z9 11
U1 1
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA
SN 0097-6156
BN 978-0-8412-2679-1
J9 ACS SYM SER
JI ACS Symp. Ser.
PY 2011
VL 1085
BP 1
EP 7
PG 7
WC Agricultural Engineering; Chemistry, Multidisciplinary
SC Agriculture; Chemistry
GA BDF55
UT WOS:000313023100001
ER
PT S
AU Ulrich, EM
Falconer, RL
AF Ulrich, Elin M.
Falconer, Renee L.
BE Garrison, AW
Gan, J
Liu, W
TI Chiral Chlordane Components in Environmental Matrices
SO CHIRAL PESTICIDES: STEREOSELECTIVITY AND ITS CONSEQUENCES
SE ACS Symposium Series
LA English
DT Proceedings Paper
CT Symposium on Modern Chiral Pesticides: Enantioselectivity and Its
Consequences
CY 2010
CL San Francisco, CA
SP ACS, Agrochem Div
ID RESOLUTION GAS-CHROMATOGRAPHY; US CORN-BELT; ORGANOCHLORINE PESTICIDES;
ENANTIOMER FRACTIONS; MASS-SPECTROMETRY; ENANTIOSELECTIVE DETERMINATION;
ALPHA-HEXACHLOROCYCLOHEXANE; BRITISH-COLUMBIA; GREAT-LAKES; CHLORINATED
PESTICIDES
AB Chlordane, a persistent, bioaccumulative and toxic organochlorine pesticide, has been studied for many years. Since the advent of chiral analysis for environmental samples, over 2,400 measurements have been made of various chiral chlordane components. Chlordane enantiomer fractions most often have been reported for air and soil with studies suggesting volatilization from soil is an important source to ambient air, although urban termiticide usage also can influence chiral chlordane measurements. Sediment core studies suggest the small amount of enantioselective degradation of chlordane likely occurs prior to deposition. In general, enantioselective degradation of chlordanes in biota occurs more frequently resulting in more nonracemic values than in other environmental media. There is also more diversity in range and enantiomer preference in biota. Analysis in plants has shown the ability to enantioselectively uptake and transport chlordane compounds from soil to root, from air to leaf and within the plant itself. Observation and measurement of chlordane enantiomers can provide a better understanding of the fate, exposure, toxicity, and risk of chlordanes and other chiral compounds in the environment.
C1 [Ulrich, Elin M.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Falconer, Renee L.] Chatham Univ, Dept Chem, Pittsburgh, PA 15232 USA.
RP Ulrich, EM (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
EM ulrich.elin@epa.gov
NR 92
TC 5
Z9 5
U1 0
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA
SN 0097-6156
BN 978-0-8412-2679-1
J9 ACS SYM SER
JI ACS Symp. Ser.
PY 2011
VL 1085
BP 11
EP +
PG 9
WC Agricultural Engineering; Chemistry, Multidisciplinary
SC Agriculture; Chemistry
GA BDF55
UT WOS:000313023100002
ER
PT S
AU Hetrick, JA
Jones, RD
Termes, SC
AF Hetrick, James A.
Jones, R. David
Termes, Silvia C.
BE Garrison, AW
Gan, J
Liu, W
TI Ecological Risk Assessment Issues for Chiral Pesticides
SO CHIRAL PESTICIDES: STEREOSELECTIVITY AND ITS CONSEQUENCES
SE ACS Symposium Series
LA English
DT Proceedings Paper
CT Symposium on Modern Chiral Pesticides: Enantioselectivity and Its
Consequences
CY 2010
CL San Francisco, CA
SP ACS, Agrochem Div
ID PHENOXYALKANOIC ACID HERBICIDES; ENANTIOSELECTIVE DEGRADATION; SOIL;
METALAXYL; AQUIFER
AB The USEPA's ecological risk assessment framework provides a clearly defined process for conducting ecological risk assessments for the registration and re-evaluation of pesticides. The ultimate product of this framework is an ecological risk characterization and assessment, which integrates data on pesticide use, chemistry, and ecotoxicity. Consideration of chiral pesticides in the risk assessment process poses numerous challenges related to the enantioselectivity in environmental fate processes and ecotoxicity. A critical assessment of risk assessment issues for chiral pesticides is discussed in the context of the USEPA risk assessment framework.
C1 [Hetrick, James A.; Jones, R. David; Termes, Silvia C.] US EPA, Off Chem Safety & Pollut Prevent, Off Pesticide Programs, Environm Fate & Effects Div 7507P, Washington, DC 20460 USA.
RP Hetrick, JA (reprint author), US EPA, Off Chem Safety & Pollut Prevent, Off Pesticide Programs, Environm Fate & Effects Div 7507P, 1200 Penn Ave, Washington, DC 20460 USA.
EM hetrick.james@epa.gov
NR 28
TC 0
Z9 0
U1 3
U2 7
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA
SN 0097-6156
BN 978-0-8412-2679-1
J9 ACS SYM SER
JI ACS Symp. Ser.
PY 2011
VL 1085
BP 183
EP 200
PG 18
WC Agricultural Engineering; Chemistry, Multidisciplinary
SC Agriculture; Chemistry
GA BDF55
UT WOS:000313023100012
ER
PT J
AU Karn, B
Kuiken, T
Otto, M
AF Karn, Barbara
Kuiken, Todd
Otto, Martha
TI Nanotechnology and in situ remediation: a review of the benefits and
potential risks
SO CIENCIA & SAUDE COLETIVA
LA English
DT Review
DE Environmental implications; Environmental technology; Hazardous wastes;
Nanoremediation; Nanotechnology; Pollutants; Remediation; Toxicity;
Waste sites; Zero-valent iron
ID NANOSCALE IRON PARTICLES; ZERO-VALENT IRON; ENGINEERED NANOPARTICLES;
WATER; ENVIRONMENT; SUSPENSIONS; TRANSPORT; FIELD; C-60; ECOTOXICOLOGY
AB In this review, we focus on environmental cleanup and provide a background and overview of current practice; research findings; societal issues; potential environment, health, and safety implications; and future directions for nanoremediation. We also discuss nanoscale zero-valent iron in detail. We searched the Web of Science for research studies and accessed recent publicly available reports from the U.S. Environmental Protection Agency and other agencies and organizations that addressed the applications and implications associated with nanoremediation techniques. We also conducted personal interviews with practitioners about specific site remediations. We aggregated information from 45 sites, a representative portion of the total projects under way, to show nanomaterials used, types of pollutants addressed, and organizations responsible for each site. Nanoremediation has the potential not only to reduce the overall costs of cleaning up large-scale contaminated sites but also to reduce cleanup time, eliminate the need for treatment and disposal of contaminated soil, and reduce some contaminant concentrations to near zero -all in situ.
C1 [Karn, Barbara; Otto, Martha] US EPA, Off Res & Dev, NCER, Washington, DC 20460 USA.
[Kuiken, Todd] Woodrow Wilson Int Ctr Scholars, Project Emerging Nanotechnol, Washington, DC 20560 USA.
RP Karn, B (reprint author), US EPA, Off Res & Dev, NCER, 8722F,1200 Penn Ave NW, Washington, DC 20460 USA.
EM karn.barbara@epa.gov
RI bee, betty/G-1104-2011; Kuiken, Todd/A-3784-2016
OI Kuiken, Todd/0000-0001-7851-6232
NR 71
TC 17
Z9 17
U1 8
U2 98
PU ABRASCO
PI RIO DE JANEIRO
PA RUA HESPERIA, 16-PARTE MANGUINHOS, RIO DE JANEIRO, 21050-040, BRAZIL
SN 1413-8123
J9 CIENC SAUDE COLETIVA
JI Cienc. Saude Coletiva
PD JAN
PY 2011
VL 16
IS 1
BP 165
EP 178
PG 14
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 697JU
UT WOS:000285510600020
PM 21180825
ER
PT J
AU Williams, LO
Dwyer, SF
Zornberg, JG
Hoyt, DL
Hargreaves, GA
AF Williams, Laura O.
Dwyer, Stephen F.
Zornberg, Jorge G.
Hoyt, Dorthea L.
Hargreaves, Gregory A.
TI Covering It All
SO CIVIL ENGINEERING
LA English
DT Article
C1 [Williams, Laura O.] US EPA, Rocky Mt Arsenal Project, Denver, CO USA.
[Dwyer, Stephen F.] Dwyer Engn LLC, Albuquerque, NM USA.
[Zornberg, Jorge G.] Univ Texas Austin, Austin, TX 78712 USA.
[Zornberg, Jorge G.] Int Geosynthet Soc, W Palm Beach, FL USA.
[Hoyt, Dorthea L.] Pacific Western Technol Ltd, Wheat Ridge, CO USA.
[Hargreaves, Gregory A.] US EPA, Oversight Team, Denver, CO USA.
RP Williams, LO (reprint author), US EPA, Rocky Mt Arsenal Project, Denver, CO USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0885-7024
J9 CIVIL ENG
JI Civil Eng.
PD JAN
PY 2011
VL 81
IS 1
BP 64
EP 71
PG 8
WC Engineering, Civil
SC Engineering
GA 705WE
UT WOS:000286170600017
ER
PT B
AU Van Emon, JM
AF Van Emon, J. M.
BE MooYoung, M
TI Immunoassays in Biotechnology
SO COMPREHENSIVE BIOTECHNOLOGY, VOL 1: SCIENTIFIC FUNDAMENTALS OF
BIOTECHNOLOGY, 2ND EDITION
LA English
DT Article; Book Chapter
ID FOOD ANALYSIS; IMMUNOSENSORS
C1 US EPA, Las Vegas, NV 89193 USA.
RP Van Emon, JM (reprint author), US EPA, Las Vegas, NV 89193 USA.
NR 14
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
BN 978-0-08-088504-9; 978-0-44-453352-4
PY 2011
BP 659
EP 667
PG 9
WC Biotechnology & Applied Microbiology
SC Biotechnology & Applied Microbiology
GA BA3SL
UT WOS:000334724000049
ER
PT B
AU McAlary, TA
Provoost, J
Dawson, HE
AF McAlary, Todd A.
Provoost, Jeroen
Dawson, Helen E.
BE Swartjes, FA
TI Vapor Intrusion
SO DEALING WITH CONTAMINATED SITES: FROM THEORY TOWARDS PRACTICAL
APPLICATION
LA English
DT Article; Book Chapter
ID ADVECTIVE-DISPERSIVE TRANSPORT; DENSE ORGANIC VAPORS; INDOOR-AIR;
UNSATURATED ZONE; AEROBIC BIODEGRADATION; GAS-TRANSPORT; SOIL;
BUILDINGS; MODEL; CONTAMINATION
AB Vapor intrusion is a pathway of potential exposure to volatile and semi-volatile contaminants (collectively referred to here as VOCs or vapors) that migrate from the subsurface to the air inside occupied buildings. Soil vapor intrusion to indoor air can occur regardless of whether a building has a basement, slab-on-grade or crawlspace design. As a basis for a mathematical model a conceptual model is needed, which describes the movement of contaminants from the source to the building, vapor migration barriers and receptors. It also provides a framework for interpreting the processes influencing the fate and transport of contaminants as they move from a source to a receptor. The approach for assessing vapor intrusion will vary from site-to-site, but there are certain elements that are appropriate in most cases. In this chapter the relevant processes have been described, like phase partitioning, biodegradation, advection and dilution within the building due to ventilation. Moreover, the presence of NAPLs, available vapor intrusion models, sampling and analysis procedures and subsurface vapor mitigation have been discussed.
C1 [McAlary, Todd A.] Geosyntec Consultants Inc, Guelph, ON, Canada.
[Dawson, Helen E.] US EPA, Denver, CO USA.
[Provoost, Jeroen] Flemish Inst Technol Res VITO, Mol, Belgium.
RP McAlary, TA (reprint author), Geosyntec Consultants Inc, Guelph, ON, Canada.
EM tmcalary@geosyntec.com; Jeroen.Provoost@yahoo.co.uk;
dawson.helen@epa.gov
NR 105
TC 3
Z9 3
U1 1
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-90-481-9756-9
PY 2011
BP 409
EP 453
DI 10.1007/978-90-481-9757-6_10
D2 10.1007/978-90-481-9757-6
PG 45
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA BTG62
UT WOS:000286907000010
ER
PT J
AU Song, YQ
Xu, Q
Park, Y
Hollenbeck, A
Schatzkin, A
Chen, HL
AF Song, Yiqing
Xu, Qun
Park, Yikyung
Hollenbeck, Albert
Schatzkin, Arthur
Chen, Honglei
TI Multivitamins, Individual Vitamin and Mineral Supplements, and Risk of
Diabetes Among Older US Adults
SO DIABETES CARE
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
NATIONAL-INSTITUTES; DIETARY CALCIUM; HEALTH; WOMEN; ASSOCIATION;
ANTIOXIDANT; POPULATION
AB OBJECTIVE- Understanding the relationship between multivitamin use and diabetes risk is important given the wide use of multivitamin supplements among U.S. adults.
RESEARCH DESIGN AND METHODS- We prospectively examined supplemental use of multivitamins and individual vitamins and minerals assessed in 1995-1996 in relation to self-reported diabetes diagnosed after 2000 among 232,007 participants in the National Institutes of Health American Association of Retired Persons Diet and Health Study. Multivitamin use was assessed by a food-frequency questionnaire at baseline. Odds ratios (ORs) and 95% CIs were calculated by logistic regression models, adjusted for potential confounders. In total, 14,130 cases of diabetes diagnosed after 2000 were included in the analysis.
RESULTS- Frequent use of any multivitamins was not associated with risk of diabetes after adjustment for potential confounders and uses of individual supplements. Compared with nonusers of any multivitamins, the multivariate ORs among users were 1.07 (95% CI 0.94-1.21) for taking vitamins less than once per week, 0.97 (0.88-1.06) for one to three times per week, 0.92 (0.84-1.00) for four to six times per week, and 1.02 (0.98-1.06) for seven or more times per week (P for trend = 0.64). Significantly lower risk of diabetes was associated with the use of vitamin C or calcium supplements. The multivariate ORs comparing daily users with nonusers were 0.91 (0.86-0.97) for vitamin C supplements and 0.85 (0.80-0.90) for calcium supplements. Use of vitamin E or other individual vitamin and mineral supplements were not associated with diabetes risk.
CONCLUSIONS- In this large cohort of U.S. older adults, multivitamin use was not associated with diabetes risk. The findings of lower diabetes risk among frequent users of vitamin C or calcium supplements warrant further evaluations.
C1 [Xu, Qun; Chen, Honglei] Natl Inst Environm Hlth Sci, Epidemiol Branch, Res Triangle Pk, NC USA.
[Xu, Qun] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Epidemiol & Hlth Stat, Beijing 100730, Peoples R China.
[Song, Yiqing] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Prevent Med, Boston, MA 02115 USA.
[Park, Yikyung; Schatzkin, Arthur] NCI, Nutr Epidemiol Branch, Rockville, MD USA.
[Hollenbeck, Albert] Amer Assoc Retired Persons, Washington, DC USA.
RP Chen, HL (reprint author), Natl Inst Environm Hlth Sci, Epidemiol Branch, Res Triangle Pk, NC USA.
EM chenh2@niehs.nih.gov
OI Chen, Honglei/0000-0003-3446-7779; Park, Yikyung/0000-0002-6281-489X
FU NIH, the National Institute of Environmental Health Sciences
[Z01-ES-101986]; National Cancer Institute [Z01 CP010196-02]; National
Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda,
Maryland [K01-DK078846]
FX This study was supported by the intramural research program of the NIH,
the National Institute of Environmental Health Sciences (Z01-ES-101986),
and the National Cancer Institute (Z01 CP010196-02). Y.S. is supported
by a grant (K01-DK078846) from the National Institute of Diabetes and
Digestive and Kidney Diseases, NIH, Bethesda, Maryland.
NR 25
TC 12
Z9 13
U1 0
U2 5
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
J9 DIABETES CARE
JI Diabetes Care
PD JAN
PY 2011
VL 34
IS 1
BP 108
EP 114
DI 10.2337/dc10-1260
PG 7
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 710FT
UT WOS:000286497000022
PM 20978095
ER
PT J
AU Puskin, JS
AF Puskin, Jerome S.
TI DEADLY RADON IN MONTANA?
SO DOSE-RESPONSE
LA English
DT Editorial Material
ID NO THRESHOLD THEORY; RADIATION CARCINOGENESIS; LUNG-CANCER
C1 US EPA, Radiat Protect Div, Washington, DC 20460 USA.
RP Puskin, JS (reprint author), US EPA, Radiat Protect Div, Washington, DC 20460 USA.
NR 6
TC 2
Z9 2
U1 1
U2 1
PU INT DOSE-RESPONSE SOC
PI AMHERST
PA UNIV MASSACHUSETTS SPH, MORRILL SCI CTR 1, N344, 639 N PLEASANT ST,
AMHERST, MA 01003-9298 USA
SN 1559-3258
J9 DOSE-RESPONSE
JI Dose-Response
PY 2011
VL 9
IS 3
BP 442
EP 442
DI 10.2203/dose-response.11-031.Puskin
PG 1
WC Pharmacology & Pharmacy; Radiology, Nuclear Medicine & Medical Imaging;
Toxicology
SC Pharmacology & Pharmacy; Radiology, Nuclear Medicine & Medical Imaging;
Toxicology
GA 832WP
UT WOS:000295840900012
PM 22013405
ER
PT J
AU Jordan, SJ
Stoffer, J
Nestlerode, JA
AF Jordan, Stephen J.
Stoffer, Jonathan
Nestlerode, Janet A.
TI Wetlands as Sinks for Reactive Nitrogen at Continental and Global
Scales: A Meta-Analysis
SO ECOSYSTEMS
LA English
DT Article
DE nitrogen; reactive nitrogen; wetlands; denitrification; nitrogen
removal; nitrogen loading
ID SALT-MARSH; CONSTRUCTED WETLANDS; RIVER-BASIN; NUTRIENT; EUTROPHICATION;
ECOSYSTEMS; RETENTION; DENITRIFICATION; SATURATION; LOADS
AB Wetlands support physical and ecological functions that result in valuable services to society, including removal of reactive nitrogen (Nr) from surface water and groundwater. We compiled published data from wetland studies worldwide to estimate total Nr removal and to evaluate factors that influence removal rates. Over several orders of magnitude in wetland area and Nr loading rates, there is a positive, near-linear relationship between Nr removal and Nr loading. The linear model (null hypothesis) explains the data better than either a model of declining Nr removal efficiency with increasing Nr loading, or a Michaelis-Menten (saturation) model. We estimate that total Nr removal by major classes of wetlands in the contiguous U.S. is approximately 20-21% of the total anthropogenic load of Nr to the region. Worldwide, Nr removal by wetlands is roughly 17% of anthropogenic Nr inputs. Historical loss of 50% of native wetland area suggests an equivalent loss of Nr removal capacity. Expanded protection and large-scale restoration of wetlands should be considered in strategies to re-balance the global nitrogen cycle and mitigate the negative consequences of excess Nr loading.
C1 [Jordan, Stephen J.; Nestlerode, Janet A.] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA.
[Stoffer, Jonathan] Texas A&M Univ, Dept Marine Biol, Galveston, TX 77553 USA.
RP Jordan, SJ (reprint author), US EPA, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA.
EM jordan.steve@epa.gov
NR 39
TC 36
Z9 40
U1 7
U2 69
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1432-9840
J9 ECOSYSTEMS
JI Ecosystems
PD JAN
PY 2011
VL 14
IS 1
BP 144
EP 155
DI 10.1007/s10021-010-9400-z
PG 12
WC Ecology
SC Environmental Sciences & Ecology
GA 732GC
UT WOS:000288172000010
ER
PT S
AU Ankley, GT
Hockett, JR
Mount, DI
Mount, DR
AF Ankley, Gerald T.
Hockett, James R.
Mount, Donald I.
Mount, David R.
BE Brack, W
TI Early Evolution of the Toxicity Identification Evaluation Process:
Contributions from the United States Environmental Protection Agency
Effluent Testing Program
SO EFFECT-DIRECTED ANALYSIS OF COMPLEX ENVIRONMENTAL CONTAMINATION
SE Handbook of Environmental Chemistry Series
LA English
DT Article; Book Chapter
DE Effluent; Toxicity; Toxicity identification evaluation
ID CHEMICAL FRACTIONATION; ESTROGENIC CHEMICALS; STW EFFLUENT; TOXICANTS;
SURFACTANTS
AB During the 1980s, whole effluent toxicity testing was incorporated into the regulatory control program for municipal and industrial effluents in the USA, as a complement to chemical-specific limitations. While regulating effluent toxicity offered several advantages, it also required the development of means to identify and control sources of toxicity within effluents, which could include toxicants not previously monitored or even known. To meet this need, the US Environmental Protection Agency developed an effects-directed analysis procedure called "toxicity identification evaluation". This involved a suite of physical/chemical manipulations that are applied to aliquots of a toxic effluent sample, and the relative effects of these manipulations on effluent toxicity are used to infer the type of toxicant(s) responsible for toxicity, and to guide their isolation and analytical identification. This chapter provides an overview of these methods and their component phases: I Characterization, II - Identification, and III - Confirmation. Case examples of toxicant identification in effluents from municipal and industrial sources are discussed, along with a broad summary of the types of toxicants identified, and the characteristics of those toxicants that helped guide their assessment.
C1 [Ankley, Gerald T.; Hockett, James R.; Mount, Donald I.; Mount, David R.] US EPA, Off Res & Dev, Duluth, MN 55804 USA.
RP Ankley, GT (reprint author), US EPA, Off Res & Dev, 6201 Congdon Blvd, Duluth, MN 55804 USA.
EM ankley.gerald@epa.gov
NR 30
TC 4
Z9 4
U1 0
U2 4
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 1433-6863
BN 978-3-642-18383-6
J9 HANDB ENVIRON CHEM
JI Handb. Environ. Chem.
PY 2011
VL 15
BP 1
EP 18
DI 10.1007/978-3-642-18384-3_1
D2 10.1007/978-3-642-18384-3
PG 18
WC Chemistry, Analytical; Environmental Sciences
SC Chemistry; Environmental Sciences & Ecology
GA BVE66
UT WOS:000291322800001
ER
PT S
AU Brack, W
Burgess, RM
AF Brack, Werner
Burgess, Robert M.
BE Brack, W
TI Considerations for Incorporating Bioavailability in Effect-Directed
Analysis and Toxicity Identification Evaluation
SO EFFECT-DIRECTED ANALYSIS OF COMPLEX ENVIRONMENTAL CONTAMINATION
SE Handbook of Environmental Chemistry Series
LA English
DT Article; Book Chapter
DE Bioaccessibility; Biota tissue; Cyclodextrin; Desorption kinetics;
Partition-based dosing; Supercritical fluid extraction; TENAX (R)
ID POLYCYCLIC AROMATIC-HYDROCARBONS; HYDROXYPROPYL-BETA-CYCLODEXTRIN;
SUPERCRITICAL-FLUID EXTRACTION; HYDROPHOBIC ORGANIC-CHEMICALS;
SOLID-PHASE MICROEXTRACTION; SEMIPERMEABLE-MEMBRANE DEVICES;
CARBON-DIOXIDE EXTRACTION; SEDIMENT-ASSOCIATED CONTAMINANTS;
PARTITION-CONTROLLED DELIVERY; SORPTION-DESORPTION BEHAVIOR
AB In order to avoid a bias toward highly toxic but poorly bioavailable compounds in the effect-directed analysis (EDA) of soils and sediments, approaches are discussed to consider bioavailability in EDA procedures. In parallel, complimentary approaches for making toxicity identification evaluations (TIEs) more capable of performing high resolution fractionation, toxicant isolation and identification are described. These approaches focus on three processes including bioaccessiblity based on desorption kinetics from the abiotic matrix, activity driven partitioning into pore water and biota tissue or a biomimetic tool, and EDA and TIE in tissues and body fluids representing toxicological bioavailability including the toxicokinetics of the selected organism. Bioaccessibility may be addressed by extraction procedures that are designed to yield rapidly desorbing fractions including mild solvent extraction, desorption into water with subsequent adsorption to a competitive adsorbent such as TENAX (R) or cyclodextrin, supercritical fluid extraction, or biomimetic extraction with gut fluids of potentially affected organisms. While equilibrium partitioning-based extraction procedures may simulate partitioning into biota quite well they often fail to provide sufficient amounts of toxicants for subsequent EDA and TIE. Partition-based dosing, which may be combined with bioaccessibility-directed extraction methods, provides an excellent tool to simulate partitioning in sediments and to provide constant and well-defined concentrations in bioassays. EDA studies in fish and mussel tissues as well as in fish bile demonstrate the potency of the identification of bioavailable toxicants in biota. Continued research on the described approaches promises to improve the usefulness of both EDA and TIE in future applications.
C1 [Brack, Werner] UFZ Helmholtz Ctr Environm Res, Dept Effect Directed Anal, D-04318 Leipzig, Germany.
[Burgess, Robert M.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA.
RP Brack, W (reprint author), UFZ Helmholtz Ctr Environm Res, Dept Effect Directed Anal, Permoserstr 15, D-04318 Leipzig, Germany.
EM werner.brack@ufz.de
NR 123
TC 5
Z9 5
U1 0
U2 4
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 1433-6863
BN 978-3-642-18383-6
J9 HANDB ENVIRON CHEM
JI Handb. Environ. Chem.
PY 2011
VL 15
BP 41
EP 68
DI 10.1007/978-3-642-18384-3_3
D2 10.1007/978-3-642-18384-3
PG 28
WC Chemistry, Analytical; Environmental Sciences
SC Chemistry; Environmental Sciences & Ecology
GA BVE66
UT WOS:000291322800003
ER
PT J
AU Pratt, MM
King, LC
Adams, LD
John, K
Sirajuddin, P
Olivero, OA
Manchester, DK
Sram, RJ
DeMarini, DM
Poirieri, MC
AF Pratt, M. Margaret
King, Leon C.
Adams, Linda D.
John, Kaarthik
Sirajuddin, Paul
Olivero, Ofelia A.
Manchester, David K.
Sram, Radim J.
DeMarini, David M.
Poirieri, Miriam C.
TI Assessment of Multiple Types of DNA Damage in Human Placentas From
Smoking and Nonsmoking Women in the Czech Republic
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Article
DE automated cellular imaging system; immunohistochemistry; BPDE-DNA
antiserum; abasic sites; (32)P-Postlabeling; Teplice Program
ID POLYCYCLIC AROMATIC-HYDROCARBONS; WHITE BLOOD-CELLS; ADDUCT FORMATION;
RISK-ASSESSMENT; AIR-POLLUTION; AMBIENT AIR; EXPOSURE;
IMMUNOHISTOCHEMISTRY; PREGNANCY; CANCER
AB Three classes of DNA damage were assessed in human placentas collected (2000-2004) from 51 women living in the Teplice region of the Czech Republic, a mining area considered to have some of the worst environmental pollution in Europe in the 1980s. Polycyclic aromatic hydrocarbon (PAH)-DNA adducts were localized and semiquantified using immunohistochemistry (IHC) and the Automated Cellular Imaging System (ACIS). More generalized DNA damage was measured both by (32)P-postlabeling and by abasic (AB) site analysis. Placenta stained with antiserum elicited against DNA modified with 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydro-benzo[a]pyrene (BPDE) revealed PAH-DNA adduct localization in nuclei of the cytotrophoblast (CT) cells and syncytiotrophoblast (ST) knots lining the chorionic villi. The highest levels of DNA damage, 49-312 PAH-DNA adducts/10(8) nucleotides, were found by IHC/ACIS in 14 immediately fixed placenta samples. An additional 37 placenta samples were stored frozen before fixation and embedding, and because PAH-DNA adducts were largely undetectable in these samples, freezing was implicated in the loss of IHC signal. The same placentas (n = 37) contained 1.7-8.6 stable/bulky DNA adducts/10(8) nucleotides and 0.6-47.2 AB sites/10(5) nucleotides. For all methods, there was no correlation among types of DNA damage and no difference in extent of DNA damage between smokers and nonsmokers. Therefore, the data show that DNA from placentas obtained in Teplice contained multiple types of DNA damage, which likely arose from various environmental exposures. In addition, PAH-DNA adducts were present at high concentrations in the CT cells and ST knots of the chorionic villi. Environ. Mol. Mutagen. 52:58-68, 2011. (C) 2010 Wiley-Liss, Inc.
C1 [Pratt, M. Margaret; John, Kaarthik; Sirajuddin, Paul; Olivero, Ofelia A.; Poirieri, Miriam C.] NCI, Carcinogen DNA Interact Sect, LCBG, Ctr Canc Res,NIH, Bethesda, MD 20892 USA.
[King, Leon C.; Adams, Linda D.; DeMarini, David M.] US EPA, Integrated Syst Toxicol Div, Res Triangle Pk, NC 27711 USA.
[Manchester, David K.] Univ Colorado Denver, Sch Med, Childrens Hosp, Aurora, CO USA.
[Sram, Radim J.] Acad Sci Czech Republic, Inst Expt Med, Prague, Czech Republic.
RP Pratt, MM (reprint author), NCI, Carcinogen DNA Interact Sect, LCBG, Ctr Canc Res,NIH, 37 Convent Dr,Bldg 37,Room 4032, Bethesda, MD 20892 USA.
EM m2pratt@yahoo.com
RI Sram, Radim/H-2455-2014
OI Sram, Radim/0000-0003-4256-3816
FU National Institutes of Health, National Cancer Institute, Center for
Cancer Research; United States Environmental Protection Agency; Czech
Ministry of Environment [SP/1b3/8/8/08]
FX Grant sponsor: Intramural Research Program of the National Institutes of
Health, National Cancer Institute, Center for Cancer Research; Grant
sponsor: The United States Environmental Protection Agency; Grant
sponsor: The Czech Ministry of Environment; Grant number: SP/1b3/8/8/08.
Margaret Pratt and Leon C. King contributed equally to this study.
NR 38
TC 9
Z9 9
U1 0
U2 5
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0893-6692
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PD JAN
PY 2011
VL 52
IS 1
BP 58
EP 68
DI 10.1002/em.20581
PG 11
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA 714CG
UT WOS:000286784500008
PM 20839217
ER
PT J
AU Singhvi, R
Taneja, A
Patel, JR
Kansal, V
Gasser, CJ
Kalnicky, DJ
AF Singhvi, Raj
Taneja, Ajay
Patel, Jay R.
Kansal, Vinod
Gasser, Charles J.
Kalnicky, Dennis J.
TI Determination of Total Metallic Mercury in Compact Fluorescent Lamps
(CFLs)
SO ENVIRONMENTAL FORENSICS
LA English
DT Article
DE metallic mercury; mercury analysis; mercury vapor; compact fluorescent
lamp (CFL)
ID ATOMIC-ABSORPTION-SPECTROMETRY; CULLET
AB The United States Environmental Protection Agency/Environmental Response Team (US EPA/ERT), in conjunction with St. John's College, Dr B R Ambedkar University, Agra, India, is conducting a study to determine mercury vapor emission rates resulting from broken compact fluorescent lamps (CFLs) in a residential setting. The overall objectives of the study are to obtain a mercury emission model and provide a homeowner with cleanup procedures and disposal options for broken CFLs. An important component in achieving these objectives is the determination of the total mercury content in CFLs for the selection of bulbs to be used in the emission study. Most of the currently available CFLs in the United States (U.S.) market are manufactured in China for U.S. companies. Several different types of CFLs were purchased from local stores and the cap and electronic parts were removed without breaking the bulb. The bulb was then placed into a 2-L polypropylene bottle containing glass stoppers or glass marbles in a mixture of nitric acid and bromine monochloride solution (BrCl). The mixture was shaken to break the lamp and allow the mercury to be completely absorbed by the BrCl. The digested samples were analyzed for mercury using standard cold vapor atomic absorption (CVAA) methods. This CFL preparation method provides excellent results for laboratory control samples (typically, 90%-110% recovery) and good repeatability for CFL bulb analyses. The sampling and analysis phases of this study are discussed in this paper.
C1 [Singhvi, Raj] US EPA, ERT, Edison, NJ 08837 USA.
[Taneja, Ajay] Dr BR Ambedkar Univ, St Johns Coll, Dept Chem, Agra, Uttar Pradesh, India.
[Patel, Jay R.; Kansal, Vinod; Gasser, Charles J.; Kalnicky, Dennis J.] SERAS, Edison, NJ USA.
RP Singhvi, R (reprint author), US EPA, ERT, 2890 Woodbridge Ave,MS101, Edison, NJ 08837 USA.
EM singhvi.raj@epa.gov
NR 16
TC 11
Z9 11
U1 1
U2 13
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1527-5922
J9 ENVIRON FORENSICS
JI Environ. Forensics
PY 2011
VL 12
IS 2
BP 143
EP 148
AR PII 938620038
DI 10.1080/15275922.2011.572953
PG 6
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 779VS
UT WOS:000291810900004
ER
PT J
AU Ela, WP
Sedlak, DL
Barlaz, MA
Henry, HF
Muir, DCG
Swackhamer, DL
Weber, EJ
Arnold, RG
Ferguson, PL
Field, JA
Furlong, ET
Giesy, JP
Halden, RU
Henry, T
Hites, RA
Hornbuckle, KC
Howard, PH
Luthy, RG
Meyer, AK
Saez, AE
vom Saal, FS
Vulpe, CD
Wiesner, MR
AF Ela, Wendell P.
Sedlak, David L.
Barlaz, Morton A.
Henry, Heather F.
Muir, Derek C. G.
Swackhamer, Deborah L.
Weber, Eric J.
Arnold, Robert G.
Ferguson, P. Lee
Field, Jennifer A.
Furlong, Edward T.
Giesy, John P.
Halden, Rolf U.
Henry, Tala
Hites, Ronald A.
Hornbuckle, Keri C.
Howard, Philip H.
Luthy, Richard G.
Meyer, Anita K.
Saez, A. Eduardo
vom Saal, Frederick S.
Vulpe, Chris D.
Wiesner, Mark R.
TI Toward Identifying the Next Generation of Superfund and Hazardous Waste
Site Contaminants
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE contaminants of emerging concern; emerging contaminant; hazardous waste
site; Superfund
ID POLYBROMINATED DIPHENYL ETHERS; PERSISTENT ORGANIC POLLUTANTS;
BROMINATED FLAME RETARDANTS; WATER TREATMENT; DRINKING-WATER;
QUANTITATIVE-DETERMINATION; EMERGING CONTAMINANTS; ESTROGENIC ACTIVITY;
GREAT-LAKES; HOUSE-DUST
AB BACKGROUND: This commentary evolved from a workshop sponsored by the National Institute of Environmental Health Sciences titled "Superfund Contaminants: The Next Generation" held in Tucson, Arizona, in August 2009. All the authors were workshop participants.
OBJECTIVES: Our aim was to initiate a dynamic, adaptable process for identifying contaminants of emerging concern (CECs) that are likely to be found in future hazardous waste sites, and to identify the gaps in primary research that cause uncertainty in determining future hazardous waste site contaminants.
DISCUSSION: Superfund-relevant CECs can be characterized by specific attributes: They are persistent, bioaccumulative, toxic, occur in large quantities, and have localized accumulation with a likelihood of exposure. Although still under development and incompletely applied, methods to quantify these attributes can assist in winnowing down the list of candidates from the universe of potential CECs. Unfortunately, significant research gaps exist in detection and quantification, environmental fate and transport, health and risk assessment, and site exploration and remediation for CECs. Addressing these gaps is prerequisite to a preventive approach to generating and managing hazardous waste sites.
CONCLUSIONS: A need exists for a carefully considered and orchestrated expansion of programmatic and research efforts to identify, evaluate, and manage CECs of hazardous waste site relevance, including developing an evolving list of priority CECs, intensifying the identification and monitoring of likely sites of present or future accumulation of CECs, and implementing efforts that focus on a holistic approach to prevention.
C1 [Ela, Wendell P.; Arnold, Robert G.; Saez, A. Eduardo] Univ Arizona, Tucson, AZ 85721 USA.
[Sedlak, David L.] Univ Calif Berkeley, Berkeley, CA 94720 USA.
[Barlaz, Morton A.] N Carolina State Univ, Raleigh, NC 27695 USA.
[Henry, Heather F.] NIEHS, Superfund Res Program, Res Triangle Pk, NC 27709 USA.
[Muir, Derek C. G.] Environm Canada, Aquat Ecosyst Protect Res Div, Burlington, ON L7R 4A6, Canada.
[Swackhamer, Deborah L.] Univ Minnesota, Environm Hlth Sci Water Res Ctr, St Paul, MN 55108 USA.
[Weber, Eric J.] US EPA, Natl Exposure Res Lab, Athens, GA USA.
[Ferguson, P. Lee; Wiesner, Mark R.] Duke Univ, Durham, NC USA.
[Field, Jennifer A.] Oregon State Univ, Corvallis, OR 97331 USA.
[Furlong, Edward T.] US Geol Survey, Natl Water Qual Lab, Denver, CO 80225 USA.
[Giesy, John P.] Univ Saskatchewan, Saskatoon, SK, Canada.
[Halden, Rolf U.] Arizona State Univ, Sch Sustainable Engn & Built Environm, Tempe, AZ USA.
[Halden, Rolf U.] Johns Hopkins Univ, Dept Environm Hlth Sci, Baltimore, MD 21205 USA.
[Henry, Tala] US EPA, Natl Program Chem Div, Washington, DC 20460 USA.
[Hites, Ronald A.] Indiana Univ, Bloomington, IN USA.
[Hornbuckle, Keri C.] Univ Iowa, Iowa City, IA USA.
[Howard, Philip H.] Syracuse Res Corp, Syracuse, NY USA.
[Luthy, Richard G.] Stanford Univ, Stanford, CA 94305 USA.
[Meyer, Anita K.] USA, Environm & Munit Ctr Expertise, Corps Engineers, Omaha, NE USA.
[vom Saal, Frederick S.] Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA.
[Vulpe, Chris D.] Univ Calif Berkeley, Berkeley, CA 94720 USA.
RP Ela, WP (reprint author), Univ Arizona, 1133 E James E Rogers Way,POB 210011, Tucson, AZ 85721 USA.
EM wela@engr.arizona.edu
RI Furlong, Edward/C-3999-2011; Hornbuckle, Keri/A-8155-2008; Ferguson,
Lee/A-5501-2013; Halden, Rolf/F-9562-2010; Saez, Avelino/K-1136-2016;
OI Furlong, Edward/0000-0002-7305-4603; Hornbuckle,
Keri/0000-0002-3478-3221; Halden, Rolf/0000-0001-5232-7361; Saez,
Avelino/0000-0002-3548-6325; Muir, Derek/0000-0001-6631-9776
FU National Institute of Environmental Health Sciences [P42-ES04940]
FX Support for the workshop, from which this article evolved, was provided
by the National Institute of Environmental Health Sciences Superfund
Research Program (P42-ES04940).
NR 55
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Z9 9
U1 2
U2 66
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD JAN
PY 2011
VL 119
IS 1
BP 6
EP 10
DI 10.1289/ehp.1002497
PG 5
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 701BI
UT WOS:000285788900017
PM 21205582
ER
PT J
AU Gwinn, MR
Craig, J
Axelrad, DA
Cook, R
Dockins, C
Fann, N
Fegley, R
Guinnup, DE
Helfand, G
Hubbell, B
Mazur, SL
Palma, T
Smith, RL
Vandenberg, J
Sonawane, B
AF Gwinn, Maureen R.
Craig, Jeneva
Axelrad, Daniel A.
Cook, Rich
Dockins, Chris
Fann, Neal
Fegley, Robert
Guinnup, David E.
Helfand, Gloria
Hubbell, Bryan
Mazur, Sarah L.
Palma, Ted
Smith, Roy L.
Vandenberg, John
Sonawane, Babasaheb
TI Meeting Report: Estimating the Benefits of Reducing Hazardous Air
Pollutants-Summary of 2009 Workshop and Future Considerations
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE air toxics; benefit analysis; economic valuation; exposure modeling;
hazardous air pollutants
ID ACROLEIN; EXPOSURE
AB Background: Quantifying the benefits of reducing hazardous air pollutants (HAPs, or air toxics) has been limited by gaps in toxicological data, uncertainties in extrapolating results from high-dose animal experiments to estimate human effects at lower doses, limited ambient and personal exposure monitoring data, and insufficient economic research to support valuation of the health impacts often associated with exposure to individual air toxics.
Objectives: To address some of these issues, the U. S. Environmental Protection Agency held the Workshop on Estimating the Benefits of Reducing Hazardous Air Pollutants (HAPs) in Washington, DC, from 30 April to 1 May 2009.
Discussion: Experts from multiple disciplines discussed how best to move forward on air toxics benefits assessment, with a focus on developing near-term capability to conduct quantitative benefits assessment. Proposed methodologies involved analysis of data-rich pollutants and application of this analysis to other pollutants, using dose-response modeling of animal data for estimating benefits to humans, determining dose-equivalence relationships for different chemicals with similar health effects, and analysis similar to that used for criteria pollutants. Limitations and uncertainties in economic valuation of benefits assessment for HAPS were discussed as well.
Conclusions: These discussions highlighted the complexities in estimating the benefits of reducing air toxics, and participants agreed that alternative methods for benefits assessment of HAPs are needed. Recommendations included clearly defining the key priorities of the Clean Air Act air toxics program to identify the most effective approaches for HAPs benefits analysis, focusing on susceptible and vulnerable populations, and improving dose-response estimation for quantification of benefits.
C1 [Gwinn, Maureen R.] US EPA, EICG, NCEA, ORD, Washington, DC 20460 USA.
[Craig, Jeneva] US EPA, Off Policy Anal & Review, Off Air & Radiat, Washington, DC 20460 USA.
[Axelrad, Daniel A.; Dockins, Chris] US EPA, Natl Ctr Environm Econ, Off Policy Econ & Innovat, Washington, DC 20460 USA.
[Cook, Rich; Helfand, Gloria] US EPA, Off Transportat & Air Qual, Off Air & Radiat, Ann Arbor, MI USA.
[Fann, Neal; Guinnup, David E.; Hubbell, Bryan; Palma, Ted; Smith, Roy L.] US EPA, Off Air Qual Planning & Stand, Off Air & Radiat, Res Triangle Pk, NC 27711 USA.
[Fegley, Robert; Mazur, Sarah L.] US EPA, Off Sci Policy, Off Res & Dev, Washington, DC 20460 USA.
[Vandenberg, John] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Gwinn, MR (reprint author), US EPA, EICG, NCEA, ORD, 1200 Penn Ave,NW,Mail Code 8623-P, Washington, DC 20460 USA.
EM gwinn.maureen@epa.gov
OI Fann, Neal/0000-0002-6724-8575; Hubbell, Bryan/0000-0002-7963-3438;
Vandenberg, John/0000-0003-2619-9460
FU U.S. Environmental Protection Agency [EPA; Office of Air and Radiation
(OAR), Office of Policy, Economics and Innovation (OPEI), and the Office
of Research and Development (ORD)]; ICF International
FX This document summarizes the conclusions from the workshop-Estimating
the Benefits of Reducing Hazardous Air Pollutants (HAPs), which was
sponsored by the U.S. Environmental Protection Agency [EPA; Office of
Air and Radiation (OAR), Office of Policy, Economics and Innovation
(OPEI), and the Office of Research and Development (ORD)] with contract
support from ICF International.
NR 31
TC 0
Z9 0
U1 0
U2 9
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD JAN
PY 2011
VL 119
IS 1
BP 125
EP 130
DI 10.1289/ehp.1002468
PG 6
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 701BI
UT WOS:000285788900034
PM 20920952
ER
PT J
AU Axelrad, DA
Cohen, J
AF Axelrad, Daniel A.
Cohen, Jonathan
TI Calculating summary statistics for population chemical biomonitoring in
women of childbearing age with adjustment for age-specific natality
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Biomonitoring; NHANES; In utero exposure; Mercury; PCBs; Cotinine;
Natality
ID US POPULATION; EXPOSURE; CHILDREN
AB The effects of chemical exposures during pregnancy on children's health have been an increasing focus of environmental health research in recent years, leading to greater interest in biomonitoring of chemicals in women of childbearing age in the general population. Measurements of mercury in blood from the National Health and Nutrition Examination Survey are frequently reported for "women of childbearing age," defined to be of ages 16-49 years. The intent is to represent prenatal chemical exposure, but blood mercury levels increase with age. Furthermore, women of different ages have different probabilities of giving birth. We evaluated options to address potential bias in biomonitoring summary statistics for women of childbearing age by accounting for age-specific probabilities of giving birth. We calculated median and 95th percentile levels of mercury, PCBs, and cotinine using these approaches: option 1: women aged 16-49 years without natality adjustment; option 2: women aged 16-39 years without natality adjustment; option 3: women aged 16-49 years, adjusted for natality by age; option 4: women aged 16-49 years, adjusted for natality by age and race/ethnicity. Among the three chemicals examined, the choice of option has the greatest impact on estimated levels of serum PCBs, which are strongly associated with age. Serum cotinine levels among Black non-Hispanic women of childbearing age are understated when age-specific natality is not considered. For characterizing in utero exposures, adjustment using age-specific natality provides a substantial improvement in estimation of biomonitoring summary statistics. Published by Elsevier Inc.
C1 [Axelrad, Daniel A.] US EPA, Off Policy 1809T, Washington, DC 20460 USA.
[Cohen, Jonathan] ICF Int, San Francisco, CA USA.
RP Axelrad, DA (reprint author), US EPA, Off Policy 1809T, Washington, DC 20460 USA.
EM axelrad.daniel@epa.gov
FU EPA [EP-W-09-030]
FX Jonathan Cohen's work was performed under EPA contract EP-W-09-030.
NR 17
TC 4
Z9 4
U1 0
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
J9 ENVIRON RES
JI Environ. Res.
PD JAN
PY 2011
VL 111
IS 1
BP 149
EP 155
DI 10.1016/j.envres.2010.10.002
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA 713DN
UT WOS:000286715300021
PM 21035114
ER
PT J
AU Gewurtz, SB
Backus, SM
Bhavsar, SP
McGoldrick, DJ
de Solla, SR
Murphy, EW
AF Gewurtz, Sarah B.
Backus, Sean M.
Bhavsar, Satyendra P.
McGoldrick, Daryl J.
de Solla, Shane R.
Murphy, Elizabeth W.
TI Contaminant biomonitoring programs in the Great Lakes region: Review of
approaches and critical factors
SO ENVIRONMENTAL REVIEWS
LA English
DT Review
DE environmental contaminants; biomonitoring programs; Great Lakes; data
analysis; study design; temporal and spatial trend analysis
ID TROUT SALVELINUS-NAMAYCUSH; POLYBROMINATED DIPHENYL ETHERS; PERSISTENT
ORGANIC POLLUTANTS; HERRING GULL EGGS; POLYCHLORINATED-BIPHENYLS PCBS;
CHLORINATED-HYDROCARBON CONTAMINATION; BULLHEADS AMEIURUS-NEBULOSUS;
WALLEYE STIZOSTEDION-VITREUM; TURTLES CHELYDRA-SERPENTINA; BROMINATED
FLAME RETARDANTS
AB Since the 1970s, several formal biomonitoring programs have been initiated to monitor temporal and spatial trends of persistent, bioaccumulative, and (or) toxic chemicals (PBTs) in the Great Lakes. Researchers have used a variety of approaches to deal with common issues that arise in these programs and there is considerable debate in the literature as to the most appropriate methods to use. Here, we critically review factors of importance in biomonitoring programs and common methods used for dealing with them under three main categories: organism-specific factors (lipid, age, size, sex, growth and bioenergetics, diet, and chemical biotransformation), study design (choice of tissue type, compositing, replication and length of monitoring program, sampling frequency, selection of contaminants to include in monitoring programs, and use of specimen banks for retrospective studies), and data analysis (accounting for changes in analytical methodology, treatment of censored data, assessment of compound classes, comparison of empirical models, mechanistic models, and spatial assessments). We use data from the literature as well as longterm measurements of polychlorinated biphenyls (PCBs) in lake trout (Salvelinus namaycush) collected in Lake Ontario as part of monitoring programs run by Environment Canada, the Ontario Ministry of the Environment, and the United States Environmental Protection Agency to illustrate these factors. We find that, in general, there are several defensible methods, ranging from simple to complex, to deal with the issues considered here, with each having specific advantages and disadvantages. The optimal approach depends largely on the program objectives, particularly if the results are meant for the public (understandable without a scientific background) or for research purposes (balance between complexity versus simplicity). Given that data analysis typically requires fewer resources compared to other aspects of monitoring programs, it may be feasible to use more than one data analysis approach to increase credibility of the results and to improve comparability of data among studies. The importance of conducting preliminary surveys and (or) pilot studies and regular review of ongoing programs (e.g., through a power analysis) is emphasized.
C1 [Gewurtz, Sarah B.; Backus, Sean M.; McGoldrick, Daryl J.] Environm Canada, Water Qual Monitoring & Surveillance Div, Water Sci & Technol Directorate, Burlington, ON L7R 4A6, Canada.
[Bhavsar, Satyendra P.] Ontario Minist Environm, Environm Monitoring & Reporting Branch, Toronto, ON M9P 3V6, Canada.
[de Solla, Shane R.] Environm Canada, Ecotoxicol & Wildlife Hlth Div, Wildlife & Landscape Sci Directorate, Burlington, ON L7R 4A6, Canada.
[Murphy, Elizabeth W.] US EPA, Great Lakes Natl Program Off, Chicago, IL 60604 USA.
RP Gewurtz, SB (reprint author), Environm Canada, Water Qual Monitoring & Surveillance Div, Water Sci & Technol Directorate, 867 Lakeshore Rd,POB 5050, Burlington, ON L7R 4A6, Canada.
EM Sarah.Gewurtz@ec.gc.ca
NR 237
TC 29
Z9 29
U1 1
U2 48
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 1200 MONTREAL ROAD, BUILDING M-55, OTTAWA, ON K1A 0R6, CANADA
SN 1208-6053
J9 ENVIRON REV
JI Environ. Rev.
PY 2011
VL 19
BP 162
EP 184
DI 10.1139/A11-005
PG 23
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 848DB
UT WOS:000297028000009
ER
PT J
AU El Badawy, AM
Silva, RG
Morris, B
Scheckel, KG
Suidan, MT
Tolaymat, TM
AF El Badawy, Amro M.
Silva, Rendahandi G.
Morris, Brian
Scheckel, Kirk G.
Suidan, Makram T.
Tolaymat, Thabet M.
TI Surface Charge-Dependent Toxicity of Silver Nanoparticles
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID GOLD; GENERATION; STRENGTH; CELLS
AB As a result of the extensive number of applications of silver nanoparticles (AgNPs), their potential impacts, once released into the environment, are of concern. The toxicity of AgNPs was reported to be dependent on various factors such as particle size, shape and capping agent Although these factors may play a role in AgNPs toxicity, the results presented herein suggest that surface charge is one of the most important factors that govern the toxicity of AgNPs. In the current study, the toxicity of four AgNPs representing various surface charging scenarios ranging from highly negative to highly positive was investigated. These AgNPs were (1) uncoated H(2)-AgNPs, (2) citrate coated AgNPs (Citrate-AgNPs), (3) polyvinylpyrrolidone coated AgNPs (PVP-AgNPs), and (4) branched polyethyleneimine coated AgNPs (BPEI-AgNPs). Our results clearly demonstrate that the AgNPs exhibited surface charge-dependent toxicity on the bacillus species investigated. Furthermore, ultrafiltration membranes were utilized to purify the AgNPs suspensions from residual impurities prior to the introduction to the microbes. This step was crucial in determining the true AgNPs toxicity and is either missing or not explicitly mentioned in most of the reported toxicity studies.
C1 [Scheckel, Kirk G.; Tolaymat, Thabet M.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
[El Badawy, Amro M.; Suidan, Makram T.] Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH 45221 USA.
[Silva, Rendahandi G.] Shaw Environm Inc, Cincinnati, OH USA.
[Morris, Brian] Pegasus Tech Serv Inc, Cincinnati, OH USA.
RP Tolaymat, TM (reprint author), US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
EM tolaymat.thabet@epa.gov
RI Scheckel, Kirk/C-3082-2009
OI Scheckel, Kirk/0000-0001-9326-9241
FU NRMRL of the USEPA, Office of Research and Development
FX This research was funded by the NRMRL of the USEPA, Office of Research
and Development. The paper has not been subjected to the Agency's
internal review, therefore, the opinions expressed in this paper are
those of the author(s) and do not, necessarily, reflect the official
positions and policies of the USEPA. Any mention of products or trade
names does not constitute recommendation for use by the USEPA. We also
thank Renata Marti for her help with the lab work.
NR 28
TC 202
Z9 203
U1 15
U2 159
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD JAN 1
PY 2011
VL 45
IS 1
BP 283
EP 287
DI 10.1021/es1034188
PG 5
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 699RA
UT WOS:000285679300043
PM 21133412
ER
PT J
AU Shane, WT
Szabo, JG
Bishop, PL
AF Shane, William T.
Szabo, Jeffrey G.
Bishop, Paul L.
TI Persistence of non-native spore forming bacteria in drinking water
biofilm and evaluation of decontamination methods
SO ENVIRONMENTAL TECHNOLOGY
LA English
DT Article
DE spores; biofilm; concrete; chlorine; decontamination
ID BACILLUS-ANTHRACIS; DISINFECTION EFFICACY; DISTRIBUTION-SYSTEMS;
CHLORINE DIOXIDE; INACTIVATION; GLOBIGII; PENETRATION; AGENTS; IRON
AB Persistence of Bacillus globigii spores, a surrogate for Bacillus anthracis, was studied on biofouled concrete-lined slides in drinking water using biofilm annular reactors. Reactors were inoculated with B. globigii spores and persistence was monitored in the bulk and biofilm phases, first in dechlorinated water and later with free chlorine concentrations of 1 and 5 mg/L. In the dechlorinated study, a steady state population of spores developed on the slides. The addition of free chlorine at 5 mg/L decreased the adhered spore density by 2-logs within 4 hours and spores were not detected after 67 and 49 hours in the presence of 1 and 5 mg/L free chlorine, respectively. This suggests that adhered spores can persist in non-chlorinated conditions, but detach and/or are inactivated upon addition of free chlorine. When injected into a chlorinated reactor, adhered spore density continually decreased and spores were either undetectable or unquantifiable by 48 hours for both 1 and 5 mg/L chlorine concentrations. Results from these experiments suggest that the presence of a free chlorine residual limits adherence of viable spores to biofouled concrete-lined pipe walls by inactivating spores before they have attached. Both free chlorine concentrations (1 and 5 mg/L) were equally effective at inactivating spores in terms of log reduction, but the higher concentrations yielded faster rates of log reduction.
C1 [Shane, William T.; Bishop, Paul L.] Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH 45221 USA.
[Szabo, Jeffrey G.] US EPA, Natl Homeland Secur Res Ctr, Water Infrastructure Protect Div, Cincinnati, OH 45268 USA.
RP Shane, WT (reprint author), Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH 45221 USA.
EM william.shane@ky.gov
FU U.S. Environmental Protection Agency (EPA) through its Office of
Research and Development [EP-C-05-056]
FX The U.S. Environmental Protection Agency (EPA) through its Office of
Research and Development funded the research described herein under
contract EP-C-05-056 to Pegasus Technical Services. It has been reviewed
by the Agency but does not necessarily reflect the Agency's views. No
official endorsement should be inferred. EPA does not endorse the
purchase or sale of any commercial products or services.
NR 18
TC 5
Z9 5
U1 0
U2 15
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0959-3330
J9 ENVIRON TECHNOL
JI Environ. Technol.
PY 2011
VL 32
IS 8
BP 847
EP 855
AR PII 938745666
DI 10.1080/09593330.2010.515038
PG 9
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 779WK
UT WOS:000291812700005
PM 21879559
ER
PT J
AU Watanabe, KH
Andersen, ME
Basu, N
Carvan, MJ
Crofton, KM
King, KA
Sunol, C
Tiffany-Castiglioni, E
Schultz, IR
AF Watanabe, Karen H.
Andersen, Melvin E.
Basu, Niladri
Carvan, Michael J., III
Crofton, Kevin M.
King, Kerensa A.
Sunol, Cristina
Tiffany-Castiglioni, Evelyn
Schultz, Irvin R.
TI DEFINING AND MODELING KNOWN ADVERSE OUTCOME PATHWAYS DOMOIC ACID AND
NEURONAL SIGNALING AS A CASE STUDY
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article; Proceedings Paper
CT SLTAC Pellston Workshop
CY APR 18-23, 2009
CL Forest Grove, OR
DE Hippocampus; Neurobehavioral; Algal; Toxin; Calcium
ID LIONS ZALOPHUS-CALIFORNIANUS; CEREBELLAR GRANULE CELLS; MINNOW
PIMEPHALES-PROMELAS; HIPPOCAMPAL SLICE CULTURES; AMNESIC SHELLFISH
POISON; PRINCE-EDWARD-ISLAND; TISSUE DISTRIBUTION; ADULT-RATS; SEA
LIONS; RECEPTOR-BINDING
AB An adverse outcome pathway (AOP) is a sequence of key events from a molecular-level initiating event and an ensuing cascade of steps to an adverse outcome with population level significance To implement a predictive strategy for ecotoxicology the multiscale nature of an AOP requires computational models to link salient processes (e g in chemical uptake toxicokinetics to toxicodynamic and population dynamics) A case study with domoic acid was used to demonstrate strategies and enable generic recommendations for developing computational models in an effort to move toward a toxicity testing paradigm focused on toxicity pathway perturbations applicable to ecological risk assessment Domoic acid an algal toxin with adverse effects on both wildlife and humans is a potent agonise for kainate receptors (ionotropic glutamate receptors whose activation leads to the influx of Na(+) and Ca(2+)) Increased Ca(2+) concentrations result in neuronal excitotoxicity and cell death primarily in the hippocampus which produces seizures impairs learning and memory and alters behavior in some species Altered neuronal Ca(2+) is a key process in domoic acid toxicity which can be evaluated in vitro Furthermore results of these assays would be amenable to mechanistic modeling for identifying domoic acid concentrations and Ca(2+) perturbations that are normal adaptive or clearly toxic In vitro assays with outputs amenable to measurement in exposed populations can link in vitro to in vivo conditions and toxicokinetic information will aid in linking in vitro results to the individual organism Development of an AOP required an iterative process with three important outcomes a critically reviewed stressor specific AOP identification of key processes suitable for evaluation with in vitro assays and strategies for model development Environ Toxicol Chem 2011 30 9-21 (C) 2010 SETAC
C1 [Schultz, Irvin R.] Battelle Pacific NW Natl Lab, Sequim, WA USA.
[Watanabe, Karen H.] Oregon Hlth & Sci Univ, Beaverton, OR USA.
[Andersen, Melvin E.] Hamner Inst Hlth Res, Res Triangle Pk, NC USA.
[Basu, Niladri] Univ Michigan, Ann Arbor, MI 48109 USA.
[Carvan, Michael J., III] Univ Wisconsin, Milwaukee, WI 53201 USA.
[Crofton, Kevin M.] US EPA, Res Triangle Pk, NC 27711 USA.
[King, Kerensa A.] Univ Washington, Seattle, WA 98195 USA.
[Sunol, Cristina] Inst Invest Biomed, Barcelona, Spain.
[Tiffany-Castiglioni, Evelyn] Texas A&M Univ, College Stn, TX USA.
RP Schultz, IR (reprint author), Battelle Pacific NW Natl Lab, Sequim, WA USA.
RI Crofton, Kevin/J-4798-2015;
OI Crofton, Kevin/0000-0003-1749-9971; Andersen,
Melvin/0000-0002-3894-4811; Basu, Niladri/0000-0002-2695-1037
NR 125
TC 39
Z9 40
U1 3
U2 25
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0730-7268
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD JAN
PY 2011
VL 30
IS 1
BP 9
EP 21
DI 10.1002/etc.373
PG 13
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 701JM
UT WOS:000285814200002
PM 20963854
ER
PT J
AU Perkins, EJ
Chipman, JK
Edwards, S
Habib, T
Falciani, F
Taylor, R
Van Aggelen, G
Vulpe, C
Antczak, P
Loguinov, A
AF Perkins, Edward J.
Chipman, J. Kevin
Edwards, Stephen
Habib, Tanwir
Falciani, Francesco
Taylor, Ronald
Van Aggelen, Graham
Vulpe, Chris
Antczak, Philipp
Loguinov, Alexandre
TI REVERSE ENGINEERING ADVERSE OUTCOME PATHWAYS
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article; Proceedings Paper
CT SETAC Pellston Workshop
CY APR 18-23, 2009
CL Forest Grove, OR
SP SETAC
DE Mechanism of action; Toxicology; Microarray; Network inference; Adverse
outcome pathway
ID BIOLOGICAL NETWORK INFERENCE; MINNOW PIMEPHALES-PROMELAS;
GENE-EXPRESSION PROFILES; MOLECULAR NETWORKS; IN-VIVO; UNDERSTAND
MECHANISMS; SIGNALING PATHWAY; SYSTEMS BIOLOGY; RISK-ASSESSMENT;
TOXICITY
AB The toxicological effects of many stressors are mediated through unknown or incompletely characterized mechanisms of action The application of reverse engineering complex interaction networks from high dimensional miles data (gene protein metabolic signaling) can be used to overcome these limitations This approach was used to characterize adverse outcome pathways (AOPs) for chemicals that disrupt the hypothalamus-pituitary gonadal endocrine axis in fathead minnows (FHM Pimephales promelas) Gene expression changes in FHM ovaries in response to seven different chemicals over different times doses and in vivo versus in vitro conditions were captured in a large data set of 868 arrays Potential AOPs of the antiandrogen flutamide were examined using two mutual information based methods to infer gene regulatory networks and potential AOPs Representative networks from these studies were used to predict network paths from stressor to adverse outcome as candidate AOPs The relationship of individual chemicals to an adverse outcome can be determined by following perturbations through the network in response to chemical treatment thus leading to the nodes associated with the adverse outcome Identification of candidate pathways allows for formation of testable hypotheses about key biological processes biomarkers or alternative endpoints that can be used to monitor an AOP Finally the unique challenges facing the application of this approach in ecotoxicology were identified and a road map for the utilization of these tools presented Environ Toxicol Chem 2011,30 22-38 (C) 2010 SETAC
C1 [Perkins, Edward J.] USA, Engn Res & Dev Ctr, Vicksburg, MS USA.
[Chipman, J. Kevin; Falciani, Francesco; Antczak, Philipp] Univ Birmingham, Birmingham, W Midlands, England.
[Edwards, Stephen] US EPA, Res Triangle Pk, NC 27711 USA.
[Habib, Tanwir] Univ So Mississippi, Hattiesburg, MS 39406 USA.
[Taylor, Ronald] Pacific NW Natl Lab, Richland, WA 99352 USA.
[Van Aggelen, Graham] Environm Canada, Vancouver, BC, Canada.
[Vulpe, Chris; Loguinov, Alexandre] Univ Calif Berkeley, Berkeley, CA 94720 USA.
RP Perkins, EJ (reprint author), USA, Engn Res & Dev Ctr, Vicksburg, MS USA.
RI Antczak, Philipp/F-4517-2011
NR 97
TC 28
Z9 30
U1 6
U2 31
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-7268
EI 1552-8618
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD JAN
PY 2011
VL 30
IS 1
BP 22
EP 38
DI 10.1002/etc.374
PG 17
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 701JM
UT WOS:000285814200003
PM 20963852
ER
PT J
AU Nichols, JW
Breen, M
Denver, RJ
Distefano, JJ
Edwards, JS
Hoke, RA
Volz, DC
Zhang, XW
AF Nichols, John W.
Breen, Miyuki
Denver, Robert J.
Distefano, Joseph J., III
Edwards, Jeremy S.
Hoke, Robert A.
Volz, David C.
Zhang, Xiaowei
TI PREDICTING CHEMICAL IMPACTS ON VERTEBRATE ENDOCRINE SYSTEMS
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article; Proceedings Paper
CT SLTAC Pellston Workshop
CY APR 18-23, 2009
CL Forest Grove, OR
DE Accommodation; Recovery; Developmental programming; Endocrine
disruption; Endocrine axis
ID ZEBRAFISH DANIO-RERIO; KILLIFISH FUNDULUS-HETEROCLITUS; MINNOW
PIMEPHALES-PROMELAS; RECEPTOR BINDING-AFFINITY; PITUITARY-THYROID AXIS;
GENE-EXPRESSION; XENOPUS-LAEVIS; FATHEAD MINNOW; COMPUTATIONAL MODEL;
ONCORHYNCHUS-MYKISS
AB Animals have evolved diverse protective mechanisms for responding to toxic chemicals of both natural and anthropogenic origin From a governmental regulatory perspective these protective responses complicate efforts to establish acceptable levels of chemical exposure To explore this issue we considered vertebrate endocrine systems as potential targets for environmental contaminants Using the hypothalamic pituitary thyroid (HPT) hypothalamic pituitary gonad (HPG) and hypothalamic-pituitary-adrenal (HPA) axes as case examples we identified features of these systems that allow them to accommodate and recover from chemical insults In doing so a distinction was made between effects on adults and those on developing organisms This distinction was required because endocrine system disruption in early life stages may alter development of organs and organ systems resulting in permanent changes in phenotypic expression later in life Risk assessments of chemicals that impact highly regulated systems must consider the dynamics of these systems in relation to complex environmental exposures A largely unanswered question is whether successful accommodation to a toxic insult exerts a fitness cost on individual animals resulting in adverse consequences for populations Mechanistically based mathematical models of endocrine systems provide a means for better understanding accommodation and recovery In the short term these models can be used to design experiments and interpret study findings Over the long term a set of validated models could be used to extrapolate limited in vitro and in vivo testing data to a broader range of untested chemicals, species and exposure scenarios With appropriate modification Tier 2 assays developed in support of the U S Environmental Protection Agency s Endocrine Disruptor Screening Program could be used to assess the potential for accommodation and recovery and inform the development of mechanistically based models Environ Toxicol Chem 2011,30 39-51 (C) 2010 SETAC
C1 [Nichols, John W.] US EPA, Duluth, MN 55804 USA.
[Breen, Miyuki] US EPA, Res Triangle Pk, NC 27711 USA.
[Breen, Miyuki] N Carolina State Univ, Raleigh, NC 27695 USA.
[Denver, Robert J.] Univ Michigan, Ann Arbor, MI 48109 USA.
[Distefano, Joseph J., III] Univ Calif Los Angeles, Los Angeles, CA USA.
[Edwards, Jeremy S.] Univ New Mexico, Albuquerque, NM 87131 USA.
[Hoke, Robert A.] Dupont Haskell Lab, Newark, DE USA.
[Volz, David C.] Univ S Carolina, Columbia, SC 29208 USA.
[Zhang, Xiaowei] Univ Saskatchewan, Saskatoon, SK, Canada.
RP Nichols, JW (reprint author), US EPA, Duluth, MN 55804 USA.
OI Zhang, Xiaowei/0000-0001-8974-9963
NR 89
TC 20
Z9 22
U1 2
U2 31
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0730-7268
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD JAN
PY 2011
VL 30
IS 1
BP 39
EP 51
DI 10.1002/etc.376
PG 13
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 701JM
UT WOS:000285814200004
PM 20963851
ER
PT J
AU Kramer, VJ
Etterson, MA
Hecker, M
Murphy, CA
Roesijadi, G
Spade, DJ
Spromberg, JA
Wang, M
Ankley, GT
AF Kramer, Vincent J.
Etterson, Matthew A.
Hecker, Markus
Murphy, Cheryl A.
Roesijadi, Guritno
Spade, Daniel J.
Spromberg, Julann A.
Wang, Magnus
Ankley, Gerald T.
TI ADVERSE OUTCOME PATHWAYS AND ECOLOGICAL RISK ASSESSMENT BRIDGING TO
POPULATION-LEVEL EFFECTS
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article; Proceedings Paper
CT SETAC Pellston Workshop
CY APR 18-23, 2009
CL Forest Grove, OR
SP SETAC
DE Risk assessment; Chemical toxicity; Adverse outcome pathway; Population
model; Pellston workshop
ID CYCLODIENE INSECTICIDE RESISTANCE; CROAKER MICROPOGONIAS-UNDULATUS;
ARYL-HYDROCARBON RECEPTOR; LIFE-HISTORY STRATEGIES; INDIVIDUAL-BASED
MODEL; FRESH-WATER GASTROPOD; ENDOCRINE DISRUPTION; FISH POPULATIONS; 2
STRAINS; ECOSYSTEMS
AB Maintaining the viability of populations of plants and animals is a key focus for environmental regulation Population level responses integrate the cumulative effects of chemical stressors on individuals as those individuals interact with and are affected by their conspecifics, competitors predators, prey habitat and other biotic and abiotic factors Models of population level effects of contaminants can integrate information from lower levels of biological organization and feed that information into higher level community and ecosystem models As individual level endpoints are used to predict population responses this requires that biological responses at lower levels of organization be translated Into a form that is usable by the population modeler In the current study we describe how mechanistic data as captured in adverse outcome pathways (AOPs) can be translated Into modeling focused on population level risk assessments First we describe the regulatory context surrounding population modeling, risk assessment and the emerging role of AOPs Then we present a succinct overview of different approaches to population modeling and discuss the types of data needed for these models We describe how different key biological processes measured at the level of the individual serve as the linkage or bridge between AOPs and predictions of population status including consideration of community level interactions and genetic adaptation Several case examples illustrate the potential for use of AOPs in population modeling and predictive ecotoxicology Finally we make recommendations for focusing toxicity studies to produce the quantitative data needed to define AOPs and to facilitate their incorporation into population modeling Environ Toxicol Chem 2011 30 64-76 (C) 2010 SETAC
C1 [Kramer, Vincent J.] Dow AgroSci, Indianapolis, IN 46268 USA.
[Etterson, Matthew A.; Ankley, Gerald T.] US EPA, Duluth, MN USA.
[Hecker, Markus] ENTRIX, Saskatoon, SK, Canada.
[Murphy, Cheryl A.] Michigan State Univ, E Lansing, MI 48824 USA.
[Roesijadi, Guritno] Pacific NW Natl Lab, Sequim, WA USA.
[Spade, Daniel J.] Univ Florida, Gainesville, FL USA.
[Spromberg, Julann A.] Natl Ocean & Atmospher Adm Fisheries, Seattle, WA USA.
[Wang, Magnus] RIFCON, Heidelberg, Germany.
RP Kramer, VJ (reprint author), Dow AgroSci, Indianapolis, IN 46268 USA.
NR 96
TC 70
Z9 75
U1 12
U2 91
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0730-7268
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD JAN
PY 2011
VL 30
IS 1
BP 64
EP 76
DI 10.1002/etc.375
PG 13
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 701JM
UT WOS:000285814200006
PM 20963853
ER
PT J
AU Fout, S
AF Fout, Shay
TI Enteric Virus and Indicator Occurrence in Groundwater Sources of Public
Drinking Water
SO EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT Joint Conference of
International-Society-of-Exposure-Science/International-Society-for-Envi
ronmental-Epidemiology
CY AUG 28-SEP 01, 2010
CL Seoul, SOUTH KOREA
SP Int Soc Exposure Sci, Int Soc Environm Epidemiol
C1 [Fout, Shay] US Environm Protect Agcy, Cincinnati, OH USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1044-3983
EI 1531-5487
J9 EPIDEMIOLOGY
JI Epidemiology
PD JAN
PY 2011
VL 22
IS 1
SU S
BP S156
EP S156
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 695VN
UT WOS:000285400800460
ER
PT J
AU Fout, S
Griffin, S
AF Fout, Shay
Griffin, Shannon
TI Microbial Exposure Science
SO EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT Joint Conference of
International-Society-of-Exposure-Science/International-Society-for-Envi
ronmental-Epidemiology
CY AUG 28-SEP 01, 2010
CL Seoul, SOUTH KOREA
SP Int Soc Exposure Sci, Int Soc Environm Epidemiol
C1 [Fout, Shay; Griffin, Shannon] US Environm Protect Agcy, Cincinnati, OH USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1044-3983
EI 1531-5487
J9 EPIDEMIOLOGY
JI Epidemiology
PD JAN
PY 2011
VL 22
IS 1
SU S
BP S156
EP S156
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 695VN
UT WOS:000285400800459
ER
PT B
AU Harwood, VJ
Ryu, H
Domingo, JS
AF Harwood, Valerie J.
Ryu, Hodon
Domingo, Jorge Santo
BE Sadowsky, MJ
Whitman, RL
TI MICROBIAL SOURCE TRACKING
SO FECAL BACTERIA
LA English
DT Article; Book Chapter
ID HUMAN FECAL POLLUTION; 16S RIBOSOMAL-RNA; ANTIBIOTIC-RESISTANCE
ANALYSIS; POLYMERASE-CHAIN-REACTION; REAL-TIME PCR; ESCHERICHIA-COLI
POPULATIONS; GEESE BRANTA-CANADENSIS; DNA-MICROARRAYS; GENETIC-MARKERS;
FRESH-WATER
C1 [Harwood, Valerie J.] Univ S Florida, Dept Integrat Biol, Tampa, FL 33620 USA.
[Ryu, Hodon; Domingo, Jorge Santo] US EPA, ORD NRMRL WSWRD MCCB, Cincinnati, OH 45268 USA.
RP Harwood, VJ (reprint author), Univ S Florida, Dept Integrat Biol, Tampa, FL 33620 USA.
RI Sadowsky, Michael/J-2507-2016
OI Sadowsky, Michael/0000-0001-8779-2781
NR 174
TC 0
Z9 0
U1 0
U2 4
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA
BN 978-1-55581-608-7
PY 2011
BP 189
EP 216
PG 28
WC Microbiology
SC Microbiology
GA BSR24
UT WOS:000285533600009
ER
PT J
AU Baird, DD
Garrett, TA
Laughlin, SK
Davis, B
Semelka, RC
Peddada, SD
AF Baird, Donna Day
Garrett, Tiana A.
Laughlin, Shannon K.
Davis, Barbara
Semelka, Richard C.
Peddada, Shyamal D.
TI Short-term change in growth of uterine leiomyoma: tumor growth spurts
SO FERTILITY AND STERILITY
LA English
DT Article
DE Uterine leiomyoma; tumor growth; fibroid size; ethnic disparity;
magnetic resonance imaging; longitudinal study; short-term variability
ID NATURAL-HISTORY; UNITED-STATES; RENAL MASSES; HYSTERECTOMY
AB Objective: To describe the short-term changes in growth of uterine leiomyomas (fibroids).
Design: Prospective observational study.
Setting: University research center.
Patient(s): Premenopausal women with fibroids (18 blacks and 18 whites) recruited through a physician network and community outreach.
Intervention(s): Not applicable.
Main Outcome Measure(s): The volumes of 101 fibroids were measured at enrollment, 3, 6, and 12 months with magnetic resonance imaging, resulting in three interval-specific growth rates. Growth spurts were defined by interval growth rates >= 30% per 3 months and substantially greater than during other intervals of observation. An overall measure of short-term change in fibroid growth was calculated as the variance of the three interval-specific growth rates.
Result(s): Growth spurts were observed in 37 of the 101 fibroids, a prevalence nearly tenfold higher than that attributable to potential measurement error. Fibroids from the same woman did not have similar short-term growth, nor were woman-specific factors (age, race/ethnicity, parity, body mass) or the fibroid position in the uterus important. However, large fibroids (>5 cm diameter) had less short-term change than smaller fibroids.
Conclusion(s): Short spurts of growth are common for fibroids, suggesting that tumor biology may change rapidly. (Fertil Steril(R) 2011;95:242-6. (C) 2011 by American Society for Reproductive Medicine.)
C1 [Baird, Donna Day; Laughlin, Shannon K.] Natl Inst Environm Hlth Sci, Epidemiol Branch, Res Triangle Pk, NC 27709 USA.
[Davis, Barbara] Natl Inst Environm Hlth Sci, Lab Womens Hlth, Res Triangle Pk, NC 27709 USA.
[Peddada, Shyamal D.] Natl Inst Environm Hlth Sci, Biostat Branch, Res Triangle Pk, NC 27709 USA.
[Garrett, Tiana A.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA.
[Semelka, Richard C.] Univ N Carolina, Dept Radiol, Chapel Hill, NC USA.
RP Baird, DD (reprint author), Natl Inst Environm Hlth Sci, Epidemiol Branch, MD A3-05, Res Triangle Pk, NC 27709 USA.
EM baird@niehs.nih.gov
RI Peddada, Shyamal/D-1278-2012; Baird, Donna/D-5214-2017
OI Baird, Donna/0000-0002-5544-2653
FU National Institute of Environmental Health Sciences (NIEHS), National
Institutes of Health [Z01ES 101663-05]; National Center on Minority
Health and Health Disparities [MO1RR00046]; NIEHS [N01-ES-95446,
273-01-C-0157]
FX Supported by the Intramural Research Program of the National Institute
of Environmental Health Sciences (NIEHS), National Institutes of Health
(Z01ES 101663-05), with partial funding from the National Center on
Minority Health and Health Disparities grant no. MO1RR00046 and NIEHS
contract nos. N01-ES-95446 and 273-01-C-0157.
NR 17
TC 20
Z9 20
U1 1
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0015-0282
J9 FERTIL STERIL
JI Fertil. Steril.
PD JAN
PY 2011
VL 95
IS 1
BP 242
EP 246
DI 10.1016/j.fertnstert.2010.05.011
PG 5
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA 695ZL
UT WOS:000285411600049
PM 21168581
ER
PT B
AU Moser, VC
AF Moser, Virginia C.
BE Bolon, B
Butt, MT
TI BEHAVIORAL MODEL SYSTEMS FOR EVALUATING NEUROPATHOLOGY
SO FUNDAMENTAL NEUROPATHOLOGY FOR PATHOLOGISTS AND TOXICOLOGISTS:
PRINCIPLES AND TECHNIQUES
LA English
DT Article; Book Chapter
ID CARBON-DISULFIDE NEUROTOXICITY; FUNCTIONAL OBSERVATIONAL BATTERY;
NEUROBEHAVIORAL SCREENING METHODS; INDUCED DELAYED NEUROPATHY;
CENTRAL-NERVOUS-SYSTEM; TRIMETHYLTIN COMPOUNDS; ACRYLAMIDE NEUROPATHY;
TESTING PROCEDURES; RISK-ASSESSMENT; DOSE-RESPONSE
C1 US EPA, Toxic Assessment Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Moser, VC (reprint author), US EPA, Toxic Assessment Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
NR 94
TC 0
Z9 0
U1 0
U2 0
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-0-470-93994-9; 978-0-470-22733-6
PY 2011
BP 105
EP 113
D2 10.1002/9780470939956
PG 9
WC Clinical Neurology; Toxicology
SC Neurosciences & Neurology; Toxicology
GA BA6JJ
UT WOS:000337159300009
ER
PT B
AU Jensen, KF
Raffaele, KC
AF Jensen, Karl F.
Raffaele, Kathleen C.
BE Bolon, B
Butt, MT
TI REGULATORY CONSIDERATIONS IN TOXICOLOGICAL NEUROPATHOLOGY
SO FUNDAMENTAL NEUROPATHOLOGY FOR PATHOLOGISTS AND TOXICOLOGISTS:
PRINCIPLES AND TECHNIQUES
LA English
DT Article; Book Chapter
ID DEVELOPMENTAL NEUROTOXICITY; POSITIVE CONTROL; WORKING
C1 [Jensen, Karl F.] US EPA, Div Neurotoxicol, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Raffaele, Kathleen C.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
RP Jensen, KF (reprint author), US EPA, Div Neurotoxicol, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
NR 18
TC 0
Z9 0
U1 0
U2 0
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-0-470-93994-9; 978-0-470-22733-6
PY 2011
BP 501
EP 504
D2 10.1002/9780470939956
PG 4
WC Clinical Neurology; Toxicology
SC Neurosciences & Neurology; Toxicology
GA BA6JJ
UT WOS:000337159300034
ER
PT J
AU Sarwar, G
Appel, KW
Carlton, AG
Mathur, R
Schere, K
Zhang, R
Majeed, MA
AF Sarwar, G.
Appel, K. W.
Carlton, A. G.
Mathur, R.
Schere, K.
Zhang, R.
Majeed, M. A.
TI Impact of a new condensed toluene mechanism on air quality model
predictions in the US
SO GEOSCIENTIFIC MODEL DEVELOPMENT
LA English
DT Article
ID SECONDARY ORGANIC AEROSOL; CARBON BOND; PART I; CMAQ; SYSTEM; EMISSIONS;
OZONE
AB A new condensed toluene mechanism is incorporated into the Community Multiscale Air Quality Modeling system. Model simulations are performed using the CB05 chemical mechanism containing the existing (base) and the new toluene mechanism for the western and eastern US for a summer month. With current estimates of tropospheric emission burden, the new toluene mechanism increases monthly mean daily maximum 8-h ozone by 1.0-3.0 ppbv in Los Angeles, Portland, Seattle, Chicago, Cleveland, northeastern US, and Detroit compared to that with the base toluene chemistry. It reduces model mean bias for ozone at elevated observed ozone concentrations. While the new mechanism increases predicted ozone, it does not enhance ozone production efficiency. A sensitivity study suggests that it can further enhance ozone if elevated toluene emissions are present. While it increases in-cloud secondary organic aerosol substantially, its impact on total fine particle mass concentration is small.
C1 [Sarwar, G.; Appel, K. W.; Carlton, A. G.; Mathur, R.; Schere, K.] US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Zhang, R.] Hong Kong Univ Sci & Technol, Dept Math, Kowloon, Hong Kong, Peoples R China.
[Majeed, M. A.] Delaware Dept Nat Resources Environm Control, New Castle, DE USA.
RP Sarwar, G (reprint author), US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
EM sarwar.golam@epa.gov
RI Carlton, Annmarie/A-7867-2011
OI Carlton, Annmarie/0000-0002-8574-1507
NR 25
TC 16
Z9 16
U1 2
U2 9
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1991-959X
J9 GEOSCI MODEL DEV
JI Geosci. Model Dev.
PY 2011
VL 4
IS 1
BP 183
EP 193
DI 10.5194/gmd-4-183-2011
PG 11
WC Geosciences, Multidisciplinary
SC Geology
GA 742AO
UT WOS:000288910700011
ER
PT J
AU Loughlin, DH
Benjey, WG
Nolte, CG
AF Loughlin, D. H.
Benjey, W. G.
Nolte, C. G.
TI ESP v1.0: methodology for exploring emission impacts of future scenarios
in the United States
SO GEOSCIENTIFIC MODEL DEVELOPMENT
LA English
DT Article
AB This article presents a methodology for creating anthropogenic emission inventories that can be used to simulate future regional air quality. The Emission Scenario Projection (ESP) methodology focuses on energy production and use, the principal sources of many air pollutants. Emission growth factors for energy system categories are calculated using the MARKAL energy system model. Growth factors for non-energy sectors are based on economic and population projections. These factors are used to grow a 2005 emissions inventory through 2050. The approach is demonstrated for two emission scenarios for the United States. Scenario 1 extends current air regulations through 2050, while Scenario 2 adds a hypothetical CO2 mitigation policy. Although both scenarios show significant reductions in air pollutant emissions through time, these reductions are more pronounced in Scenario 2, where the CO2 policy results in the adoption of technologies with lower emissions of both CO2 and traditional air pollutants. The methodology is expected to play an important role within an integrated modeling framework that supports the US EPA's investigations of linkages among emission drivers, climate and air quality.
C1 [Loughlin, D. H.] US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
[Benjey, W. G.; Nolte, C. G.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Loughlin, DH (reprint author), US EPA, Natl Risk Management Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM loughlin.dan@epa.gov
RI Nolte, Christopher/H-4345-2012
OI Nolte, Christopher/0000-0001-5224-9965
NR 27
TC 23
Z9 23
U1 0
U2 12
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1991-959X
J9 GEOSCI MODEL DEV
JI Geosci. Model Dev.
PY 2011
VL 4
IS 2
BP 287
EP 297
DI 10.5194/gmd-4-287-2011
PG 11
WC Geosciences, Multidisciplinary
SC Geology
GA 781NF
UT WOS:000291939100004
ER
PT J
AU Appel, KW
Foley, KM
Bash, JO
Pinder, RW
Dennis, RL
Allen, DJ
Pickering, K
AF Appel, K. W.
Foley, K. M.
Bash, J. O.
Pinder, R. W.
Dennis, R. L.
Allen, D. J.
Pickering, K.
TI A multi-resolution assessment of the Community Multiscale Air Quality
(CMAQ) model v4.7 wet deposition estimates for 2002-2006
SO GEOSCIENTIFIC MODEL DEVELOPMENT
LA English
DT Article
ID CONTINENTAL UNITED-STATES; MESOSCALE METEOROLOGICAL MODEL; ATMOSPHERIC
BOUNDARY-LAYER; NONLOCAL CLOSURE-MODEL; NITROGEN DEPOSITION; EMISSION
INVENTORY; PART II; SYSTEM; OZONE; FLUX
AB This paper examines the operational performance of the Community Multiscale Air Quality (CMAQ) model simulations for 2002-2006 using both 36-km and 12-km horizontal grid spacing, with a primary focus on the performance of the CMAQ model in predicting wet deposition of sulfate (SO(4)(=)), ammonium (NH(4)(+)) and nitrate (NO(3)(-)). Performance of the wet deposition estimates from the model is determined by comparing CMAQ predicted concentrations to concentrations measured by the National Acid Deposition Program (NADP), specifically the National Trends Network (NTN). For SO(4)(=) wet deposition, the CMAQ model estimates were generally comparable between the 36-km and 12-km simulations for the eastern US, with the 12-km simulation giving slightly higher estimates of SO(4)(=) wet deposition than the 36-km simulation on average. The result is a slightly larger normalized mean bias (NMB) for the 12-km simulation; however both simulations had annual biases that were less than +/- 15% for each of the five years. The model estimated SO(4)(=) wet deposition values improved when they were adjusted to account for biases in the model estimated precipitation. The CMAQ model underestimates NH(4)(+) wet deposition over the eastern US, with a slightly larger underestimation in the 36-km simulation. The largest underestimations occur in the winter and spring periods, while the summer and fall have slightly smaller underestimations of NH(4)(+) wet deposition. The underestimation in NH(4)(+) wet deposition is likely due in part to the poor temporal and spatial representation of ammonia (NH(3)) emissions, particularly those emissions associated with fertilizer applications and NH(3) bidirectional exchange. The model performance for estimates of NO(3)(-) wet deposition are mixed throughout the year, with the model largely underestimating NO(3)(-) wet deposition in the spring and summer in the eastern US, while the model has a relatively small bias in the fall and winter. Model estimates of NO(3)(-) wet deposition tend to be slightly lower for the 36-km simulation as compared to the 12-km simulation, particularly in the spring. The underestimation of NO(3)(-) wet deposition in the spring and summer is due in part to a lack of lightning generated NO emissions in the upper troposphere, which can be a large source of NO in the spring and summer when lightning activity is the high. CMAQ model simulations that include production of NO from lightning show a significant improvement in the NO(3)(-) wet deposition estimates in the eastern US in the summer. Overall, performance for the 36-km and 12-km CMAQ model simulations is similar for the eastern US, while for the western US the performance of the 36-km simulation is generally not as good as either eastern US simulation, which is not entire unexpected given the complex topography in the western US.
C1 [Appel, K. W.; Foley, K. M.; Bash, J. O.; Pinder, R. W.; Dennis, R. L.] US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC USA.
[Allen, D. J.] Univ Maryland, Dept Atmospher & Ocean Sci, College Pk, MD 20742 USA.
[Pickering, K.] NASA Goddard, Atmospher Chem & Dynam Branch, Greenbelt, MD USA.
RP Appel, KW (reprint author), US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC USA.
EM appel.wyat@epa.gov
RI Pinder, Robert/F-8252-2011; Pickering, Kenneth/E-6274-2012; Bash,
Jesse/E-9688-2013; Allen, Dale/F-7168-2010;
OI Pinder, Robert/0000-0001-6390-7126; Allen, Dale/0000-0003-3305-9669;
Bash, Jesse/0000-0001-8736-0102
FU United States Environmental Protection Agency through its Office of
Research and Development
FX The United States Environmental Protection Agency through its Office of
Research and Development funded and managed the research described here.
It has been subjected to Agency review and approved for publication.
NR 35
TC 40
Z9 40
U1 2
U2 26
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1991-959X
J9 GEOSCI MODEL DEV
JI Geosci. Model Dev.
PY 2011
VL 4
IS 2
BP 357
EP 371
DI 10.5194/gmd-4-357-2011
PG 15
WC Geosciences, Multidisciplinary
SC Geology
GA 781NF
UT WOS:000291939100008
ER
PT S
AU Princiotta, FT
AF Princiotta, Frank T.
BE Princiotta, FT
TI Global Climate Change and the Mitigation Challenge
SO GLOBAL CLIMATE CHANGE - THE TECHNOLOGY CHALLENGE
SE Advances in Global Change Research
LA English
DT Article; Book Chapter
ID STABILIZATION
AB This chapter aims to provide a succinct integration of the projected warming the earth is likely to experience in the decades ahead, the emission reductions that may be needed to constrain this warming, and the technologies needed to help achieve these emission reductions. Transparent modeling tools and the most recent literature are used, to quantify the challenge posed by climate change and potential technological remedies. The chapter examines forces driving CO2 emissions, how different emission trajectories could affect warming this century, a sector-by-sector summary of mitigation options, and R&D priorities. It is concluded that it is too late too avoid substantial warming; the best result that appears achievable, would be to constrain warming to about 2 degrees C (range of 1.3-2.7 degrees C) above pre-industrial levels by 2100. In order to constrain warming to such a level, the current annual 3% CO2 emission growth rate needs to transform rapidly to an annual decrease rate of from 2% to 3% for decades. Further, the current generation of energy generation and end use technologies are capable of achieving less than half of the emission reduction needed for such a major mitigation program. New technologies will have to be developed and deployed at a rapid rate, especially for the key power generation and transportation sectors. Current energy technology research, development, demonstration and deployment programs fall far short of what is required.
C1 US EPA, Air Pollut Prevent & Control Div, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27709 USA.
RP Princiotta, FT (reprint author), US EPA, Air Pollut Prevent & Control Div, Off Res & Dev, Natl Risk Management Res Lab, TW Alexander Dr 109, Res Triangle Pk, NC 27709 USA.
EM princiotta.frank@epa.gov; princiotta.frank@epa.gov
NR 24
TC 8
Z9 8
U1 0
U2 2
PU SPRINGER
PI DORDRECHT
PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS
SN 1574-0919
BN 978-90-481-3152-5
J9 ADV GLOB CHANGE RES
JI Adv. Glob. Change Res.
PY 2011
VL 38
BP 1
EP 50
DI 10.1007/978-90-481-3153-2_1
D2 10.1007/978-90-481-3153-2
PG 50
WC Energy & Fuels; Environmental Sciences; Environmental Studies
SC Energy & Fuels; Environmental Sciences & Ecology
GA BVY51
UT WOS:000293147500001
ER
PT S
AU Thompson, R
Jetter, J
Marr, D
Owens, C
AF Thompson, Robert
Jetter, James
Marr, David
Owens, Clyde
BE Princiotta, FT
TI Buildings: Mitigation Opportunities with a Focus on Health Implications
SO GLOBAL CLIMATE CHANGE - THE TECHNOLOGY CHALLENGE
SE Advances in Global Change Research
LA English
DT Article; Book Chapter
ID LIFE-CYCLE; ENERGY USE; INDOOR; CANADA
AB Addressing building energy use is the critical first step in any strategic plan for mitigating climate change. Buildings have a direct impact on estimated global climate change due to their large carbon footprint. Energy use in the building sector is the largest man-made contributor to climate change, and coincidentally a key sector to start mitigating climate change. To avoid revisiting problems such as sick building syndrome arising from aggressive building weatherization programs in the 1970s, it is critical that policy makers, regulators, and strategic planners remember that the primary function of buildings is not saving energy. The bottom line of why we build buildings is for safety and comfort in our homes, to enhance productivity in the work-place, and to ensure an optimal learning environment in our schools. The fundamental services of improving human health, comfort, productivity, and performance should not be compromised as we strive to minimize energy use in buildings. A one-dimensional focus on energy could result in unsustainable policies and practices. Much is understood about technologies, materials, and design techniques that can reduce energy use in buildings. However, much attention must be paid to recognizing how these approaches can enhance or damage human health and productivity as well as the environment. The focus of this chapter is not existing energy sectors and conservation technologies that have been extensively understood and considered in the literature, but on underutilized mitigation techniques that both increase the sustainability of our buildings while maintaining a focus on human health and the environment. A key intersection between climate change, buildings, and human health is building materials and products, and an effective testing and information transfer program is urgently needed so that building stakeholders have the information and tools they need to make good decisions during the design, construction, operation, and renovation phases of buildings.
C1 [Thompson, Robert; Jetter, James; Marr, David; Owens, Clyde] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Air Pollut Prevent & Control Div, Cincinnati, OH 45268 USA.
RP Thompson, R (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Air Pollut Prevent & Control Div, Cincinnati, OH 45268 USA.
EM bob.thompson@epa.gov
NR 31
TC 1
Z9 1
U1 1
U2 6
PU SPRINGER
PI DORDRECHT
PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS
SN 1574-0919
BN 978-90-481-3152-5
J9 ADV GLOB CHANGE RES
JI Adv. Glob. Change Res.
PY 2011
VL 38
BP 225
EP 240
DI 10.1007/978-90-481-3153-2_7
D2 10.1007/978-90-481-3153-2
PG 16
WC Energy & Fuels; Environmental Sciences; Environmental Studies
SC Energy & Fuels; Environmental Sciences & Ecology
GA BVY51
UT WOS:000293147500007
ER
PT S
AU Srivastava, RK
Vijay, S
Torres, E
AF Srivastava, Ravi K.
Vijay, Samudra
Torres, Elineth
BE Princiotta, FT
TI Reduction of Multi-pollutant Emissions from Industrial Sectors: The US
Cement Industry - A Case Study
SO GLOBAL CLIMATE CHANGE - THE TECHNOLOGY CHALLENGE
SE Advances in Global Change Research
LA English
DT Article; Book Chapter
AB Carbon dioxide (CO2) accounts for more than 90% of worldwide CO2-eq greenhouse gas (GHG) emissions from industrial sectors other than power generation. Amongst these sectors, the cement industry is one of the larger industrial sources of CO2 emissions. In 2005, this industry accounted for about 6% of the global anthropogenic CO2 emissions. Further, global production of cement has been growing steadily, with the main growth being in Asia. Considering these trends, the worldwide cement industry is a key industrial sector relative to CO2 emissions.
The development of policy options for managing emissions and air quality can be made more effective and efficient through sophisticated analyses of relevant technical and economic factors. Such analyses are greatly enhanced by the use of an appropriate modeling framework. Accordingly, the Industrial Sectors Integrated Solutions (ISIS) model for industrial sectors is under development at the U.S. Environmental Protection Agency (U.S. EPA). Currently, this model is populated with data on the U.S. cement-manufacturing sector and efforts are underway to build representations of the U.S. pulp and paper and iron and steel sectors.
In this chapter, ISIS was used to conduct an example analysis of the U.S. cement sector to gain some insights relative to two broad questions: (1) what range of CO2 reductions may be practicable in the near-term, and (2) for that range, what may be the market characteristics for the U.S. cement industry. These questions are relevant because in the absence of carbon capture and sequestration (CCS) technology, the path forward for reducing CO2 emissions in the near-term (e.g., decade ending 2020) will need to depend on the currently available energy efficiency measures and raw material and product substitution approaches.
C1 [Srivastava, Ravi K.; Vijay, Samudra] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Air Pollut Prevent & Control Div, Cincinnati, OH 45268 USA.
[Torres, Elineth] US EPA, Off Air Qual Planning & Stand, Sect Policy & Programs Div, Res Triangle Pk, NC 27711 USA.
[Vijay, Samudra] Sam Analyt Solut LLC, Morrisville, NC 27560 USA.
[Vijay, Samudra] US EPA, Air Pollut Prevent & Control Div, Natl Risk Management Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Srivastava, RK (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Air Pollut Prevent & Control Div, Cincinnati, OH 45268 USA.
EM sam@samanalyticsolutions.com
NR 46
TC 2
Z9 2
U1 1
U2 4
PU SPRINGER
PI DORDRECHT
PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS
SN 1574-0919
BN 978-90-481-3152-5
J9 ADV GLOB CHANGE RES
JI Adv. Glob. Change Res.
PY 2011
VL 38
BP 241
EP 272
DI 10.1007/978-90-481-3153-2_8
D2 10.1007/978-90-481-3153-2
PG 32
WC Energy & Fuels; Environmental Sciences; Environmental Studies
SC Energy & Fuels; Environmental Sciences & Ecology
GA BVY51
UT WOS:000293147500008
ER
PT S
AU Brooks, MC
Wood, AL
Jawitz, JW
AF Brooks, Michael C.
Wood, A. Lynn
Jawitz, James W.
BE Schirmer, M
Hoehn, E
Vogt, T
TI Source functions for multi-component DNAPLs based on streamtube analysis
SO GQ10: GROUNDWATER QUALITY MANAGEMENT IN A RAPIDLY CHANGING WORLD
SE IAHS Publication
LA English
DT Proceedings Paper
CT 7th International Groundwater Quality Conference
CY JUN 13-18, 2010
CL Eawag, Zurich, SWITZERLAND
SP Int Assoc Hydrol Sci, Swiss Natl Sci Fdn, Swiss Fed Off Env, STS Sensors Ltd, AF Colenco Ltd, NAGRA, Swiss Cooperative Disposal Radioactive Waste, Intera Inc, CHGeol, Swiss Assoc Geol, Simultec AG, Roche, Innovat Messtechnik Weiss, Bachema AG, SVGW, Swiss Assoc Gas & Water, Solexperts Ltd, Stump Foratec Ltd, Malcolm Pirnie
HO Eawag
DE DNAPL; contaminant flux; remediation; modelling
ID AQUIFER REMEDIATION SYSTEMS; DESIGN
AB The purpose of this work is to investigate source functions for multicomponent DNAPLs under heterogeneous conditions using a streamtube approach. Heterogeneity in the hydraulic conductivity field is represented by a collection of streamtubes with a distribution of travel times, and the DNAPL is assumed to be distributed uniformly across all streamtubes. Dissolution from each streamtube is assumed to follow Raoult's law. Results are used to assess how multi-component dissolution alters the source function relative to single component dissolution, as well as assess the relative importance of hydraulic conductivity heterogeneity and multi-component dissolution on the source function. Source functions for both single and multi-component DNAPLs indicate that flushing efficiency decreases as solubility decreases. However, this effect is more pronounced for the less soluble compounds in the multi-component case due to the preferential elution of the more soluble compounds. Source functions for both single and multi-component DNAPLs also indicate that greater flux reduction is achieved through less mass removal as heterogeneity increases, however the effect is less pronounced in the multi-component case.
C1 [Brooks, Michael C.; Wood, A. Lynn] US EPA, Off Res & Dev, Natl Risk Management Res Lab, GWERD, Ada, OK 74820 USA.
RP Brooks, MC (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, GWERD, Ada, OK 74820 USA.
EM brooks.michael@epa.gov
NR 6
TC 0
Z9 0
U1 0
U2 1
PU INT ASSOC HYDROLOGICAL SCIENCES
PI WALLINGFORD
PA INST OF HYDROLOGY, WALLINGFORD OX10 8BB, ENGLAND
SN 0144-7815
BN 978-1-907161-16-2
J9 IAHS-AISH P
PY 2011
VL 342
BP 132
EP 135
PG 4
WC Water Resources
SC Water Resources
GA BYC83
UT WOS:000298021100029
ER
PT J
AU Patete, JM
Peng, XH
Koenigsmann, C
Xu, Y
Karn, B
Wong, SS
AF Patete, Jonathan M.
Peng, Xiaohui
Koenigsmann, Christopher
Xu, Yan
Karn, Barbara
Wong, Stanislaus S.
TI Viable methodologies for the synthesis of high-quality nanostructures
SO GREEN CHEMISTRY
LA English
DT Review
ID MICROWAVE-ASSISTED SYNTHESIS; SUPERCRITICAL-CARBON-DIOXIDE; IRON-OXIDE
NANOPARTICLES; ONE-DIMENSIONAL NANOSTRUCTURES; BARIUM FLUORIDE
NANOPARTICLES; FACILE SONOCHEMICAL ROUTE; FUNGUS FUSARIUM-OXYSPORUM;
CITRATE COMPLEX PRECURSOR; IMIDAZOLIUM IONIC LIQUIDS; CHEMICAL FLUID
DEPOSITION
AB The development of environmentally benign methods for the synthesis of nanomaterials has become increasingly relevant as chemists look to shape a more sustainable future. In this critical review, we present current work towards developing alternative methods for synthesizing a wide range of high-quality nanomaterials with predictable and controllable size, shape, composition, morphology and crystallinity. In particular, we focus on the inherent advantages of utilizing porous membrane templates, ultrasonic and microwave irradiation, alternative solvent systems, as well as biologically-inspired reagents as reasonably cost-effective, environmentally responsible methods to generate metal, metal oxide, fluoride, sulfide, selenide and phosphate nanomaterials.
C1 [Patete, Jonathan M.; Peng, Xiaohui; Koenigsmann, Christopher; Xu, Yan; Wong, Stanislaus S.] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA.
[Karn, Barbara] US EPA, Off Res & Dev, NCER, Washington, DC 20460 USA.
[Wong, Stanislaus S.] Brookhaven Natl Lab, Condensed Matter Phys & Mat Sci Dept, Upton, NY 11973 USA.
RP Patete, JM (reprint author), SUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA.
EM sswong@notes.cc.sunysb.edu
FU U.S. Department of Energy [DE-AC02-98CH10886]; Alfred P. Sloan
Foundation
FX We acknowledge the U.S. Department of Energy (DE-AC02-98CH10886) and the
Alfred P. Sloan Foundation for PI and student support.
NR 436
TC 66
Z9 66
U1 6
U2 138
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1463-9262
J9 GREEN CHEM
JI Green Chem.
PY 2011
VL 13
IS 3
BP 482
EP 519
DI 10.1039/c0gc00516a
PG 38
WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY
SC Chemistry; Science & Technology - Other Topics
GA 731RF
UT WOS:000288126300002
ER
PT J
AU Balu, AM
Baruwati, B
Serrano, E
Cot, J
Garcia-Martinez, J
Varma, RS
Luque, R
AF Balu, Alina M.
Baruwati, Babita
Serrano, Elena
Cot, Jaume
Garcia-Martinez, Javier
Varma, Rajender S.
Luque, Rafael
TI Magnetically separable nanocomposites with photocatalytic activity under
visible light for the selective transformation of biomass-derived
platform molecules
SO GREEN CHEMISTRY
LA English
DT Article
ID RAY PHOTOELECTRON-SPECTROSCOPY; DOPED TIO2; TITANIUM-OXIDE;
HETEROGENEOUS PHOTOCATALYSIS; HYDROGEN GENERATION; ANATASE TIO2;
DEGRADATION; IRRADIATION; CARBON; NANOPARTICLES
AB Novel magnetically separable TiO(2)-guanidine-(Ni,Co)Fe(2)O(4) nanomaterials were prepared and characterised by a series of techniques including XRD, SEM, TEM, N(2) physisorption as well as XPS and subsequently tested for their photocatalytic activities in the selective transformation of malic acid in aqueous solution. The modification with guanidine, which remarkably decreases the band gap of the metal oxide, was found to have a significant effect in the photocatalytic activity of the materials under visible light, showing a remarkably superior activity to that of the commercial Degussa P25. These materials are also envisaged to have interesting photocatalytic activities under sunlight.
C1 [Balu, Alina M.; Luque, Rafael] Univ Cordoba, Dpto Quim Organ, E-14014 Cordoba, Spain.
[Baruwati, Babita; Varma, Rajender S.; Luque, Rafael] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
[Serrano, Elena; Garcia-Martinez, Javier] Univ Alicante, Dept Inorgan Chem, Mol Nanotechnol Lab, E-03690 Alicante, Spain.
[Cot, Jaume] Inst Quim Avancada Catalunya CID CSIC, Barcelona 08034, Spain.
RP Balu, AM (reprint author), Univ Cordoba, Dpto Quim Organ, Campus Rabanales,Edif Marie Curie,Ctra Nnal 4,Km, E-14014 Cordoba, Spain.
EM q62alsor@uco.es; Varma.Rajender@epamail.epa.gov
RI Balu, Alina /G-4425-2010; Luque, Rafael/F-9853-2010; Balu, Alina
/H-7935-2015;
OI Balu, Alina /0000-0002-8872-3400; Luque, Rafael/0000-0003-4190-1916;
Balu, Alina /0000-0002-8872-3400; garcia-martinez,
javier/0000-0002-7089-4973; Serrano, Elena/0000-0003-3340-6675
FU Ministerio de Ciencia e Innovacion for the concession of a Ramon y Cajal
[RYC-2009-04199]; Consejeria de Ciencia e Innovacion; Junta de Andalucia
[P10-FQM-6711]; Incentivos para Actividades de caracter cientifico y
tecnico for RL at the EPA in Cincinnati [IAC-2010-2]; Spanish MICINN
through the JdC [JCI-2008-2165]; Departamento de Quimica Organica,
Universidad de Cordoba [FQM-162]; Ministerio de Ciencia e Innovacion
[CTQ 2008-01330/BQU]; Consejeria de Educacion y Ciencia, Junta de
Andalucia [P07-FQM-02965, P09-FQM-4781]; FEDER; ORISE
FX Rafael Luque gratefully acknowledges Ministerio de Ciencia e Innovacion
for the concession of a Ramon y Cajal contract (RYC-2009-04199) and
Consejeria de Ciencia e Innovacion, Junta de Andalucia for funding under
project P10-FQM-6711 as well as for funding a short stay fellowship
Incentivos para Actividades de caracter cientifico y tecnico for RL
(convocatoria IAC-2010-2) at the EPA in Cincinnati. Elena Serrano
acknowledges financial support from Spanish MICINN through the JdC
Program (ref. JCI-2008-2165). Alina Balu gratefully acknowledges funds
from the research group FQM-162, Departamento de Quimica Organica,
Universidad de Cordoba and from Ministerio de Ciencia e Innovacion
(Project CTQ 2008-01330/BQU) and Consejeria de Educacion y Ciencia,
Junta de Andalucia (Projects P07-FQM-02965 and P09-FQM-4781),
co-financed with FEDER funds. BB thanks ORISE for a research fellowship.
NR 60
TC 51
Z9 51
U1 4
U2 43
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1463-9262
J9 GREEN CHEM
JI Green Chem.
PY 2011
VL 13
IS 10
BP 2750
EP 2758
DI 10.1039/c1gc15692f
PG 9
WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY
SC Chemistry; Science & Technology - Other Topics
GA 829KR
UT WOS:000295579700022
ER
PT J
AU Boethling, RS
AF Boethling, Robert S.
TI Incorporating environmental attributes into musk design
SO GREEN CHEMISTRY
LA English
DT Article
ID METABOLIC BIOTRANSFORMATION RATES; PREDICTING READY BIODEGRADABILITY;
PERSISTENT ORGANIC POLLUTANTS; FRESH-WATER FISH; SYNTHETIC MUSKS;
AQUATIC ENVIRONMENT; FRAGRANCE CHEMISTRY; UNITED-STATES; WASTE-WATER;
HUMAN-MILK
AB The design of the molecule itself is the earliest phase in the process of developing useful products. Two of the 12 green chemistry principles, which state that chemicals should be designed to have minimal toxicity and degrade environmentally to innocuous products, are central to chemical design. Previously we used a series of case studies to show that generalizations about the effects of molecular structure can be used to design small molecules for biodegradability. Here, we extend one of the case studies (synthetic musk fragrances) to a wider range of structures, and address all three PBT properties (persistence, bioaccumulation, toxicity). To this end, we first summarize ready biodegradation and aquatic toxicity data for musks including unpublished data from US Premanufacture Notice (PMN) chemicals. Bioaccumulation potential is then estimated for this set of musks using EPA's BCFBAFC (c) (a component of EPI Suite (c)), KOAWIN (c) and ECOSAR (c) programs, and the results are used to compare musks across the various structural classes and make inferences about their environmental attributes. Last, the analysis is extended to target molecules. In this way we show how predictive methods and knowledge can be included as additional facets in rational design of small molecules.
C1 US EPA, Off Pollut Prevent & Tox, Washington, DC 20460 USA.
RP Boethling, RS (reprint author), US EPA, Off Pollut Prevent & Tox, Washington, DC 20460 USA.
EM Boethling.bob@epa.gov
NR 73
TC 6
Z9 6
U1 2
U2 12
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1463-9262
J9 GREEN CHEM
JI Green Chem.
PY 2011
VL 13
IS 12
BP 3386
EP 3396
DI 10.1039/c1gc15782e
PG 11
WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY
SC Chemistry; Science & Technology - Other Topics
GA 853KL
UT WOS:000297424900010
ER
PT J
AU Johnson, TB
Mckay, LD
Layton, AC
Jones, SW
Johnson, GC
Cashdollar, JL
Dahling, DR
Villegas, LF
Fout, GS
Williams, DE
Sayler, G
AF Johnson, Trisha B.
McKay, Larry D.
Layton, Alice C.
Jones, Sidney W.
Johnson, Greg C.
Cashdollar, Jennifer L.
Dahling, Daniel R.
Villegas, Leah F.
Fout, G. Shay
Williams, Daniel E.
Sayler, Gary
TI Viruses and Bacteria in Karst and Fractured Rock Aquifers in East
Tennessee, USA
SO GROUND WATER
LA English
DT Article
ID REVERSE TRANSCRIPTION-PCR; HUMAN ENTERIC VIRUSES; CELL-CULTURE;
GROUNDWATER; WATER; POLLUTION
AB A survey of enteric viruses and indicator bacteria was carried out in eight community water supply sources (four wells and four springs) in East Tennessee. Seven sites derived their water from carbonate aquifers and one from fractured sandstone. Four of the sites were deemed "low-risk" based on prior monitoring of fecal indicators and factors such as presence of thick layers of overlying sediments. The remaining sites were deemed "high-risk." Enteric viruses (enterovirus and reovirus) were detected by cell culture at least once in seven of the eight wells or springs including all but one of the four low-risk sites. Viral RNA, however, was not detected in any of the samples by reverse transcription-polymerase chain reaction. Conventional indicators of microbial contamination (Escherichia coli and total coliform bacteria) were detected together with culturable viruses in seven of nine virus positive samples. Bacteroides, an alternative fecal indicator which has not previously been used in groundwater investigations, was also detected in all but one of the samples containing E. coli or total coliform bacteria, as well as in one sample where viruses were present in the absence of other bacterial indicators. The study highlights some of the challenges involved in surveys of virus occurrence and indicates that culturable enteric viruses in East Tennessee karst aquifers may be more widespread than previously observed in studies of karst aquifers in Pennsylvania (8%), the Ozark region of Missouri (< 1%), or several other states covered in a national microbial water quality survey conducted by the U.S. Environmental Protection Agency (43%).
C1 [McKay, Larry D.] Univ Tennessee, Dept Earth & Planetary Sci, Knoxville, TN 37996 USA.
[Johnson, Trisha B.] Clancy Environm Consultants Inc, St Albans, VT 05478 USA.
[McKay, Larry D.; Layton, Alice C.; Williams, Daniel E.; Sayler, Gary] Univ Tennessee, Ctr Environm Biotechnol, Knoxville, TN 37996 USA.
[Jones, Sidney W.] Tennessee Dept Environm & Conservat, Oak Ridge, TN 37830 USA.
[Cashdollar, Jennifer L.; Dahling, Daniel R.; Villegas, Leah F.; Fout, G. Shay] US EPA, Natl Exposure Res Lab, Knoxville, TN 37921 USA.
[Johnson, Greg C.] US Geol Survey, Tennessee Water Sci Ctr, Knoxville, TN 37921 USA.
RP Johnson, TB (reprint author), Univ Tennessee, Dept Earth & Planetary Sci, Knoxville, TN 37996 USA.
EM lmckay@utk.edu
FU Tennessee Department of Environment and Conservation (TDEC); University
of Tennessee Institute for a Secure and Sustainable Environment
FX The authors would like to thank: Gretchen Sullivan at EPA-NERL in
Cincinnati, Ohio, for her invaluable help in the laboratory; the
Tennessee Department of Environment and Conservation (TDEC) for project
funding and data; and the participating water utilities for providing
data and access to sites. Additional funding for T. Johnson at the end
of the project was provided by the University of Tennessee Institute for
a Secure and Sustainable Environment.
NR 28
TC 11
Z9 11
U1 2
U2 21
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0017-467X
J9 GROUND WATER
JI Ground Water
PD JAN-FEB
PY 2011
VL 49
IS 1
BP 98
EP 110
DI 10.1111/j.1745-6584.2010.00698.x
PG 13
WC Geosciences, Multidisciplinary; Water Resources
SC Geology; Water Resources
GA 700NW
UT WOS:000285751700011
PM 20331750
ER
PT J
AU Hazari, MS
Lamb, C
Carll, AP
Krantz, Q
Haykal-Coates, N
Winsett, DW
Costa, DL
Farraj, AK
AF Hazari, M. S.
Lamb, C.
Carll, A. P.
Krantz, Q.
Haykal-Coates, N.
Winsett, D. W.
Costa, D. L.
Farraj, A. K.
TI INCREASED RISK OF CARDIAC ARRHYTHMIA IN RATS EXPOSED TO DIESEL EXHAUST
AIR POLLUTION IS MEDIATED BY THE NOCICEPTIVE TRANSIENT RECEPTOR
POTENTIAL A1 (TRPA1)
SO HEART
LA English
DT Meeting Abstract
CT 2010 Autumn Meeting on British-Society-for-Cardiovascular-Research
CY SEP 06-07, 2010
CL London, ENGLAND
SP British Soc Cardiovasc Res
C1 [Hazari, M. S.; Krantz, Q.; Haykal-Coates, N.; Winsett, D. W.; Costa, D. L.; Farraj, A. K.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Lamb, C.; Carll, A. P.] Univ N Carolina, Chapel Hill, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1355-6037
J9 HEART
JI Heart
PD JAN
PY 2011
VL 97
IS 1
MA 08
DI 10.1136/hrt.2010.213496.8
PG 10
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA 692WL
UT WOS:000285186500009
ER
PT J
AU Gavrelis, N
Sertkaya, A
Bertelsen, L
Cuthbertson, B
Phillips, L
Moya, J
AF Gavrelis, Naida
Sertkaya, Aylin
Bertelsen, Liz
Cuthbertson, Becky
Phillips, Linda
Moya, Jacqueline
TI An Analysis of the Proportion of the US Population that Ingests Soil or
Other Non-Food Substances
SO HUMAN AND ECOLOGICAL RISK ASSESSMENT
LA English
DT Article
DE ingestion; pica; prevalence; soil; non-food substance; children
ID PREGNANT-WOMEN; PICA PRACTICES; EXPOSURE; CHILDREN; MISSISSIPPI;
PREVALENCE
AB Reliable quantitative data are lacking that document the prevalence of ingestion of soil and other "non-food" substances among U.S. children and adults. This article explores the proportion of the U.S. population that ingests substances such as soil, clay, starch, paint, or plaster. We compiled data from the National Health and Nutrition Examination Survey (NHANES) collected from years 1971-1975 (NHANES I) and 1976-1980 (NHANES II) because these particular surveys asked participants specific questions about non-food ingestion practices. We examined the prevalence of the behavior across multiple demographic variables, such as age, gender, education, and income level. Approximately 1% (NHANES II) to 2.5% (NHANES I) of the U.S. population ingests some type of non-food substance. The most notable variation across the demographic subgroups studied was the difference in estimated prevalence among young children (1 to <3 years) compared to older children and adults. Estimated prevalence was also higher among blacks compared to whites and within lower compared to higher socioeconomic groups. This analysis helps fill data gaps on the relative pattern of non-food ingestion practices on a national scale. This information provides perspective for risk assessors when evaluating exposure variables and for risk managers when weighing risk management alternatives.
C1 [Gavrelis, Naida; Sertkaya, Aylin] Eastern Res Grp Inc, Lexington, MA 02421 USA.
[Bertelsen, Liz] Eastern Res Grp Inc, Atlanta, GA USA.
[Cuthbertson, Becky] US EPA, Off Solid Waste & Emergency Response, Washington, DC 20460 USA.
[Phillips, Linda; Moya, Jacqueline] US EPA, Off Res & Dev, Washington, DC 20460 USA.
RP Gavrelis, N (reprint author), Eastern Res Grp Inc, 110 Hartwell Ave, Lexington, MA 02421 USA.
EM naida.gavrelis@erg.com
NR 25
TC 2
Z9 2
U1 2
U2 6
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1080-7039
J9 HUM ECOL RISK ASSESS
JI Hum. Ecol. Risk Assess.
PY 2011
VL 17
IS 4
BP 996
EP 1012
DI 10.1080/10807039.2011.588162
PG 17
WC Biodiversity Conservation; Environmental Sciences
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 874LQ
UT WOS:000298959400018
ER
PT S
AU Kodavanti, PRS
AF Kodavanti, Prasada Rao S.
BE Costa, LG
Giordano, G
Guizzetti, M
TI Cell Signaling and Neurotoxicity: Protein Kinase C In Vitro and In Vivo
SO IN VITRO NEUROTOXICOLOGY: METHODS AND PROTOCOLS
SE Methods in Molecular Biology
LA English
DT Article; Book Chapter
DE Protein kinase C; Calcium signaling; Learning and memory; Neurotoxicity;
Nervous system development
ID ACTIVATION; GROWTH; EXPRESSION; EXPOSURE; ISOFORMS; CULTURES; BINDING;
MEMORY; PKC
AB There is a growing concern about the effects of chemicals on the developing nervous system. Chemical exposure at critical periods of development can be associated with effects ranging from subtle to pro-found on the structure and/or function of the nervous system. Understanding critical biological molecular targets, which underlie chemical-induced neurotoxicity, will provide a scientific basis for risk assessment. Cell signaling molecules such as protein kinase C (PKC) have been shown to play critical roles in motor activity, development of the nervous system, and in learning and memory. PKC also has been shown to be associated with several neurological disorders including Alzheimer's disease, status epilepticus, and cerebellar ataxia. In the literature, there is abundant information linking PKC to cognitive function, long-term potentiation, or brain structural changes. Here, we show the relationship between changes in PKC (as assayed using radioactive material or by western blots) and the neurotoxic effects caused by environmental chemicals in vitro and in vivo.
C1 US EPA, Neurotoxicol Branch, Natl Hlth & Environm Effects Res Labs, Res Triangle Pk, NC 27711 USA.
RP Kodavanti, PRS (reprint author), US EPA, Neurotoxicol Branch, Natl Hlth & Environm Effects Res Labs, Res Triangle Pk, NC 27711 USA.
NR 24
TC 2
Z9 2
U1 0
U2 0
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
SN 1064-3745
BN 978-1-61779-169-7
J9 METHODS MOL BIOL
JI Methods Mol. Biol.
PY 2011
VL 758
BP 307
EP 319
DI 10.1007/978-1-61779-170-3_21
D2 10.1007/978-1-61779-170-3
PG 13
WC Biochemical Research Methods; Biochemistry & Molecular Biology; Public,
Environmental & Occupational Health
SC Biochemistry & Molecular Biology; Public, Environmental & Occupational
Health
GA BWF36
UT WOS:000293799700021
PM 21815075
ER
PT S
AU Kodavanti, PRS
AF Kodavanti, Prasada Rao S.
BE Costa, LG
Giordano, G
Guizzetti, M
TI Cell Signaling and Neurotoxicity: H-3-Arachidonic Acid Release
(Phospholipase A(2)) in Cerebellar Granule Neurons
SO IN VITRO NEUROTOXICOLOGY: METHODS AND PROTOCOLS
SE Methods in Molecular Biology
LA English
DT Article; Book Chapter
DE Phospholipase A(2); Arachidonic acid release; Neurotoxicity; Cell
signaling; Persistent chemicals; Cytotoxicity
ID ARACHIDONIC-ACID; POLYCHLORINATED-BIPHENYLS; RAT CEREBELLUM; GLUTAMATE;
INDUCTION; SURVIVAL; DISEASE; CULTURE; TERM
AB Cell signaling is a complex process which controls basic cellular activities and coordinates actions to maintain normal cellular homeostasis. Alterations in signaling processes have been associated with neurological diseases, such as Alzheimer's and cerebellar ataxia, as well as cancer, autoimmunitiy, and diabetes. Recent evidence also indicates a role for signaling molecules in the adverse effects associated with the exposure to environmental chemicals. One of these signaling molecules is arachidonic acid (AA). AA is abundant in the membrane phospholipids of the brain, where its release has been shown to be involved in synaptic plasticity processes, such as long-term potentiation. AA release is primarily produced by the activation of phospholipases, most commonly by phospholipase A(2) (PLA(2)). The release of H-3-AA is often used as a measure of PLA(2) activity in cell culture studies. In our laboratory, we have demonstrated the relationship between the stimulation of H-3-AA release by persistent chemicals, such as polychlorinated biphenyls and polybrominated diphenyl ethers, and the associated cytotoxicity following in vitro exposure. Understanding the role of the AA signaling pathway in chemically-induced effects on the nervous system will provide specific mode of action information that can be used in assessing the compound risk.
C1 US EPA, Neurotoxicol Branch, Natl Hlth & Environm Effects Res Labs, Res Triangle Pk, NC 27711 USA.
RP Kodavanti, PRS (reprint author), US EPA, Neurotoxicol Branch, Natl Hlth & Environm Effects Res Labs, Res Triangle Pk, NC 27711 USA.
NR 20
TC 0
Z9 0
U1 0
U2 1
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
SN 1064-3745
BN 978-1-61779-169-7
J9 METHODS MOL BIOL
JI Methods Mol. Biol.
PY 2011
VL 758
BP 321
EP 328
DI 10.1007/978-1-61779-170-3_22
D2 10.1007/978-1-61779-170-3
PG 8
WC Biochemical Research Methods; Biochemistry & Molecular Biology; Public,
Environmental & Occupational Health
SC Biochemistry & Molecular Biology; Public, Environmental & Occupational
Health
GA BWF36
UT WOS:000293799700022
PM 21815076
ER
PT S
AU Harrill, JA
Mundy, WR
AF Harrill, Joshua A.
Mundy, William R.
BE Costa, LG
Giordano, G
Guizzetti, M
TI Quantitative Assessment of Neurite Outgrowth in PC12 Cells
SO IN VITRO NEUROTOXICOLOGY: METHODS AND PROTOCOLS
SE Methods in Molecular Biology
LA English
DT Article; Book Chapter
DE PC12 cells; Neurite growth; Photomicroscopy; Immunofluorescence;
High-content analysis
ID DIFFERENTIATION; NEUROTOXICITY
AB In vitro test methods can provide a rapid approach for the screening of large numbers of chemicals for their potential to produce toxicity. In order to identify potential developmental neurotoxicants, assessment of critical neurodevelopmental processes, such as neuronal differentiation and growth has been proposed. PC12 cells have been widely used to study the neurotrophic factor-induced signaling pathways that control differentiation, and as in vitro models to detect the effect of chemicals on neurite outgrowth. Upon exposure to nerve growth factor (NGF), PC12 cells cease to proliferate, extend multiple neurites, and acquire the properties of sympathetic neurons. Measurement of the number and length of neurites during exposure to NGF provides a quantitative assessment of neuronal differentiation and growth. Differentiation and neurite outgrowth can be measured using simple contrast microscopy in live cells, or using automated imaging systems in cells prepared with immunocytochemistry.
C1 [Harrill, Joshua A.; Mundy, William R.] US EPA, Syst Biol Branch, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Labs, Res Triangle Pk, NC 27711 USA.
RP Harrill, JA (reprint author), US EPA, Syst Biol Branch, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Labs, Res Triangle Pk, NC 27711 USA.
NR 9
TC 11
Z9 11
U1 0
U2 5
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
SN 1064-3745
BN 978-1-61779-169-7
J9 METHODS MOL BIOL
JI Methods Mol. Biol.
PY 2011
VL 758
BP 331
EP 348
DI 10.1007/978-1-61779-170-3_23
D2 10.1007/978-1-61779-170-3
PG 18
WC Biochemical Research Methods; Biochemistry & Molecular Biology; Public,
Environmental & Occupational Health
SC Biochemistry & Molecular Biology; Public, Environmental & Occupational
Health
GA BWF36
UT WOS:000293799700023
PM 21815077
ER
PT J
AU Johns, DO
Linn, WS
AF Johns, Douglas O.
Linn, William S.
TI A review of controlled human SO2 exposure studies contributing to the US
EPA integrated science assessment for sulfur oxides
SO INHALATION TOXICOLOGY
LA English
DT Review
DE Sulfur dioxide; controlled human exposures; National Ambient Air Quality
Standards; bronchoconstriction; asthma
ID DIOXIDE-INDUCED BRONCHOCONSTRICTION; HEART-RATE-VARIABILITY; DRY COLD
AIR; ASTHMATIC SUBJECTS; EXERCISING ASTHMATICS; DOSE-RESPONSE;
PULMONARY-FUNCTION; NITROGEN-DIOXIDE; LUNG-FUNCTION; 0.5 PPM
AB Laboratory studies involving intentional and highly controlled exposures to air pollutants among groups of human volunteers provide valuable information related to the potential health effects of pollutants regulated under the US Clean Air Act. These controlled human exposure studies often provide biological plausibility for the associations between air-pollutant concentration and a given health endpoint observed in epidemiologic investigations. In some cases, results from human laboratory studies provide evidence of a relevant health effect at ambient or near-ambient concentrations and thus directly support the selection of air quality standard levels. In the recently completed review of the US National Ambient Air Quality Standards (NAAQS) for sulfur dioxide (SO2), the US Environmental Protection Agency (EPA) concluded that short-term exposures to SO2 are causally associated with an increase in respiratory morbidity. This determination was based in large part on findings from laboratory studies of controlled exposures to SO2 among small groups of asthmatic individuals. The purpose of this review is to concisely present an overview of the evidence from controlled human exposure studies of SO2-induced respiratory health effects following short-term exposures. While the majority of these studies were conducted over 20 years ago, the findings and insights gained from this work continues to play an integral role in evaluating the respiratory effects of ambient exposures to SO2.1 year). Stent thrombosis continued to increase to at least 11 years with BMS and to at least 4.5 years with DES. Stent thrombosis rates with BMS versus DES were similar at 1 year (5.1% and 4.0%, respectively) but increased more with DES after the first year (1.9%/year vs. 0.6%/year, respectively). Landmark analysis (>1 year) found DES had a higher frequency of VLSI (p < 0.001) and reinfarction (p = 0.003). DES was the only significant independent predictor of VLST (hazard ratio: 3.79, 95% confidence interval: 1.64 to 8.79, p = 0.002).
Conclusions VLST after primary PCI for STEN occurs with relatively high frequency to at least 11 years with BMS and to at least 4.5 years with DES. Very late stent thrombosis and reinfarction (>1 year) were more frequent with DES. New strategies are needed to manage this problem. (J Am Coll Cardiol Intv 2011;4:30-8) (C) 2011 by the American College of Cardiology Foundation
C1 [Brodie, Bruce; Fleishman, Nathan; Bensimhon, Adam; Milks, Sally; Cooper, Michael; McAlhany, Christopher; Stuckey, Tom] Moses Cone Mem Hosp, LeBauer Cardiovasc Res Fdn, Greensboro, NC 27408 USA.
[Kissling, Grace] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
[Pokharel, Yashashwi; Hansen, Charles] Moses Cone Mem Hosp, Internal Med Residency Program, Greensboro, NC 27408 USA.
RP Brodie, B (reprint author), Moses Cone Mem Hosp, LeBauer Cardiovasc Res Fdn, 313 Meadowbrook Terrace, Greensboro, NC 27408 USA.
EM bbrodie@triad.rr.com
FU LeBauer Charitable Research Foundation; National Institutes of Health,
National Institute of Environmental Health Sciences [Z01ES045005]
FX This study was supported by an unrestricted grant from the LeBauer
Charitable Research Foundation. This research was supported, in part, by
the Intramural Research Program of the National Institutes of Health,
National Institute of Environmental Health Sciences (Z01ES045005). Dr.
Brodie has served on the Speakers' Bureau for The Medicines Company and
Medrad/Possis. Dr. Stuckey has served as consultant and on the Speakers'
Bureau and Advisory Board for Boston Scientific Corporation. All other
authors have reported that they have no relationships to disclose.
NR 24
TC 47
Z9 54
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1936-8798
J9 JACC-CARDIOVASC INTE
JI JACC-Cardiovasc. Interv.
PD JAN
PY 2011
VL 4
IS 1
BP 30
EP 38
DI 10.1016/j.jcin.2010.11.004
PG 9
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA 719EA
UT WOS:000287181500004
PM 21251626
ER
PT J
AU Hunter, RH
Sykes, K
Lowman, SG
Duncan, R
Satariano, WA
Belza, B
AF Hunter, Rebecca H.
Sykes, Kathy
Lowman, Sarah G.
Duncan, Richard
Satariano, William A.
Belza, Basia
TI Environmental and Policy Change to Support Healthy Aging
SO JOURNAL OF AGING & SOCIAL POLICY
LA English
DT Article
DE aging; environment; housing; neighborhood design; physical activity;
policy; safety; transportation; universal design
ID OLDER-ADULTS; PHYSICAL-ACTIVITY; BUILT ENVIRONMENT; NEIGHBORHOOD
ENVIRONMENT; UNITED-STATES; DISABILITY; MOBILITY; WALKING; COMMUNITIES;
OBESITY
AB Given the growing evidence of the influence of the environment on older adult health, the need to design and implement effective environmental policy around healthy and vital aging is urgent. This article describes issues amenable to improvement through policy change, evidence supporting specific policy approaches and outcomes, and promising strategies for implementing those approaches. Key areas of focus are neighborhood design and safety, housing, transportation, and mobility. Strategies to build capacity for policy change are also addressed. Our goals are to foster greater attention to environmental change in support of healthy aging and to illuminate directions for policy change.
C1 [Hunter, Rebecca H.] Univ N Carolina, Inst Aging, Chapel Hill, NC 27599 USA.
[Sykes, Kathy] US EPA, Aging Initiat, Off External Affairs & Environm Educ, Washington, DE USA.
[Lowman, Sarah G.] Univ N Carolina, Ctr Aging & Hlth, Sch Med, Chapel Hill, NC 27599 USA.
[Duncan, Richard] RL Mace Universal Design Inst, Chapel Hill, NC USA.
[Satariano, William A.] Univ Calif Berkeley, Sch Publ Hlth, Div Community Hlth & Human Dev, Berkeley, CA 94720 USA.
[Belza, Basia] Univ Washington, Sch Nursing, Seattle, WA 98195 USA.
[Belza, Basia] Univ Washington, Sch Publ Hlth, Seattle, WA 98195 USA.
RP Hunter, RH (reprint author), Univ N Carolina, Inst Aging, CB 1030, Chapel Hill, NC 27599 USA.
EM rebecca_hunter@unc.edu
RI Mavoa, Suzanne/B-5372-2010
FU NCCDPHP CDC HHS [U48-DP-001924, U48-DP-001908, U48-DP-001911,
U48-DP-001921, U48-DP-001936, U48-DP-001938, U48-DP-001944]; NCRR NIH
HHS [UL1 RR025014]
NR 57
TC 6
Z9 7
U1 0
U2 15
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0895-9420
J9 J AGING SOC POLICY
JI J. Aging Soc. Policy
PY 2011
VL 23
IS 4
BP 354
EP 371
DI 10.1080/08959420.2011.605642
PG 18
WC Gerontology
SC Geriatrics & Gerontology
GA 888JR
UT WOS:000300000300003
PM 21985064
ER
PT J
AU Hasan, JA
Japal, KM
Christensen, ER
Samalot-Freire, LC
AF Hasan, Jafrul A.
Japal, Knoxley M.
Christensen, Erick R.
Samalot-Freire, Luisa C.
TI In vitro Production of Clostridium difficile Spores for Use in the
Efficacy Evaluation of Disinfectants: A Precollaborative Investigation
SO JOURNAL OF AOAC INTERNATIONAL
LA English
DT Article
ID DISEASE; EPIDEMIC; SPORULATION; GERMINATION; STRAINS
AB Clostridium difficile is a strict anaerobic spore-forming bacterium, and an increasingly common nosocomial pathogen. The U.S. Environmental Protection Agency (EPA) is responsible for the registration of disinfectants, including products designed to treat environmental surfaces contaminated with spores of C. difficile. Product efficacy data are required for registration; however, there is a lack of methodology for generating high-quality spore suspensions for evaluating product performance. As such, a study was carried out to select a suitable C. difficile strain and to develop a stand-alone method to prepare a spore suspension that meets specific criteria necessary for quantitative testing of disinfectants. The criteria are: (1) a spore titer of >8 log(10)/mL, (2) >= 90% spores to vegetative cells, and (3) resistance of spores (determined by viability) to 2.5 M hydrochloric acid (HCl). Several strains of C. difficile (toxigenic and nontoxigenic) were grown on various media (solid and liquid) for varying lengths of time to determine the best combination of incubation conditions and media to optimize spore production and quality. Once the spore production procedure was optimized, a toxigenic strain of C. difficile [American Type Culture Collection (ATCC) 43598] was selected for use in trials to verify repeatability from one production run to the next. The spore suspension was initiated by spreading vegetative cells of C. difficile (ATCC 43598) on CDC anaerobic 5% sheep blood agar plates and incubating for 7-10 days at 36 +/- 1 degrees C under anaerobic conditions. Spores were harvested when >= 90% of the cells converted to spores as determined by observation using phase-contrast microscopy. The spores were washed three times with saline-Tween-80, resuspended in cold deionized water, heated to 70 degrees C for 10 min, evaluated microscopically for quality, and enumerated on cycloserine-cefoxitin-fructose agar containing horse blood and taurocholate. The spore suspension was used to inoculate brushed stainless steel carriers (1 cm in diameter) with and without a soil load in accordance with the Standard Quantitative Carrier Disk Test Method (ASTM E-2197-02) to determine carrier load. Once it was determined that >6 log(10) spores/carrier could be recovered, spores were evaluated for resistance to HCl. The sporulation method presented in this report is simple and repeatable and results in spore suspension of high titer (>8 log(10)/mL) and quality (>= 90%) spores to vegetative cells) that met acid resistance criteria (spores were resistant to 2.5 M HCl for 10 min). In addition, recovery from brushed stainless steel carriers with and without soil load was >6 log(10) spores/carrier. A 6 log(10) performance standard was set forth in the EPA's interim guidance for generating data to support a label claim for effectiveness against C. difficile spores on hard, nonporous surfaces. This precollaborative investigation successfully demonstrated the use of a methodology for in vitro production of C. difficile spores (ATCC 43598) necessary for conducting efficacy tests. A proposal will be submitted to the AOAC INTERNATIONAL Methods Committee on Antimicrobial Efficacy Testing for a collaborative study; see Appendix.
C1 [Hasan, Jafrul A.; Japal, Knoxley M.; Christensen, Erick R.; Samalot-Freire, Luisa C.] US EPA, Off Pesticide Programs, Microbiol Lab, Ctr Environm Sci, Ft George G Meade, MD 20755 USA.
RP Hasan, JA (reprint author), US EPA, Off Pesticide Programs, Microbiol Lab, Ctr Environm Sci, Ft George G Meade, MD 20755 USA.
EM hasan.jafrul@epa.gov
NR 32
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U1 2
U2 8
PU AOAC INT
PI GAITHERSBURG
PA 481 N FREDRICK AVE, STE 500, GAITHERSBURG, MD 20877-2504 USA
SN 1060-3271
J9 J AOAC INT
JI J. AOAC Int.
PD JAN-FEB
PY 2011
VL 94
IS 1
BP 259
EP 272
PG 14
WC Chemistry, Analytical; Food Science & Technology
SC Chemistry; Food Science & Technology
GA 719QA
UT WOS:000287222000030
PM 21391503
ER
PT J
AU Mielke, PW
Berry, KJ
Johnston, JE
AF Mielke, Paul W., Jr.
Berry, Kenneth J.
Johnston, Janis E.
TI Robustness without rank order statistics
SO JOURNAL OF APPLIED STATISTICS
LA English
DT Article
DE analysis space; Euclidean distance; rank-order statistics; robustness
ID PERMUTATION TESTS; F-TEST; VARIANCE; ASSOCIATION; COEFFICIENT; SCIENCES;
SAMPLES
AB An alternative to conventional rank tests based on a Euclidean distance analysis space is described. Comparisons based on exact probability values among classical two-sample t-tests and the Wilcoxon-Mann-Whitney test illustrate the advantages of the Euclidean distance analysis space alternative.
C1 [Berry, Kenneth J.] Colorado State Univ, Dept Sociol, Ft Collins, CO 80523 USA.
[Mielke, Paul W., Jr.] Colorado State Univ, Dept Stat, Ft Collins, CO 80523 USA.
[Johnston, Janis E.] US EPA, Natl Homeland Secur Res Ctr, Washington, DC 20460 USA.
RP Berry, KJ (reprint author), Colorado State Univ, Dept Sociol, Ft Collins, CO 80523 USA.
EM berry@mail.colostate.edu
NR 39
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Z9 0
U1 1
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0266-4763
EI 1360-0532
J9 J APPL STAT
JI J. Appl. Stat.
PY 2011
VL 38
IS 1
BP 207
EP 214
AR PII 926477123
DI 10.1080/02664760903406439
PG 8
WC Statistics & Probability
SC Mathematics
GA 692JK
UT WOS:000285148900016
ER
PT J
AU Klein, MD
Sinha, BK
Subramaniam, RP
AF Klein, Martin D.
Sinha, Bimal K.
Subramaniam, Ravi P.
TI Statistical Inferences from Formaldehyde DNA-Protein Cross-Link Data:
Improving Methods for Characterization of Uncertainty
SO JOURNAL OF BIOPHARMACEUTICAL STATISTICS
LA English
DT Article
DE DNA-protein cross-links (DPX); Formaldehyde; Nonlinear regression
models; Ordinary differential equations; PBPK models
ID POPULATION TOXICOKINETICS; INHALED FORMALDEHYDE; FISCHER-344 RATS;
COVALENT BINDING; RHESUS-MONKEYS; PHARMACOKINETICS; HUMANS; MODEL;
TETRACHLOROETHYLENE; DISPOSITION
AB Physiologically based pharmacokinetic (PBPK) modeling has reached considerable sophistication in its application to pharmacological and environmental health problems. Yet, mature methodologies for making statistical inferences have not been routinely incorporated in these applications except in a few data-rich cases. This paper demonstrates how improved statistical inference on estimated model parameters from both frequentist and Bayesian points of view can be routinely carried out. We work with a previously developed PBPK model for the formation and disposition of DNA-protein cross-links formed by inhaled formaldehyde in the nasal lining of rats and rhesus monkeys. We purposefully choose this model because it is based on sparse time-course data.
C1 [Klein, Martin D.] US Bur Census, Ctr Stat Res & Methodol, Washington, DC 20233 USA.
[Sinha, Bimal K.] Univ Maryland Baltimore Cty, Dept Math & Stat, Baltimore, MD 21228 USA.
[Subramaniam, Ravi P.] US EPA, Off Res & Dev, Washington, DC 20460 USA.
RP Klein, MD (reprint author), US Bur Census, Ctr Stat Res & Methodol, 4600 Silver Hill Rd, Washington, DC 20233 USA.
EM martin.klein@census.gov
FU Oak Ridge Institute for Science and Education through an interagency
agreement between the USDOE and USEPA
FX Our sincere thanks are due to Paul White and Paul Schlosser of the U.S.
Environmental Protection Agency for various discussions and
encouragement on this topic. Thanks to two reviewers and an associate
editor for their helpful comments which substantially improved the
quality of the paper. Bimal Sinha's research was supported in part by an
appointment to the Research Participation Program for USEPA/ORD
administered by the Oak Ridge Institute for Science and Education
through an interagency agreement between the USDOE and USEPA. This
report is released to inform interested parties of research and to
encourage discussion. The views expressed in this article are solely
those of the authors and do not necessarily reflect the views or
policies of the U.S. Census Bureau or the U.S. Environmental Protection
Agency, or the views of those we acknowledge. This work constitutes a
portion of Martin Klein's doctoral dissertation research completed at
the University of Maryland, Baltimore County.
NR 26
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U1 1
U2 5
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1054-3406
J9 J BIOPHARM STAT
JI J. Biopharm. Stat.
PY 2011
VL 21
IS 1
BP 42
EP 55
AR PII 931674482
DI 10.1080/10543400903531601
PG 14
WC Pharmacology & Pharmacy; Statistics & Probability
SC Pharmacology & Pharmacy; Mathematics
GA 700SQ
UT WOS:000285765000004
PM 21191853
ER
PT J
AU Klemick, H
AF Klemick, Heather
TI Shifting cultivation, forest fallow, and externalities in ecosystem
services: Evidence from the Eastern Amazon
SO JOURNAL OF ENVIRONMENTAL ECONOMICS AND MANAGEMENT
LA English
DT Article
DE Forest; Farms; Fallow; Ecosystem services; Land use; Spatial
econometrics; Externalities; Brazil
ID SLASH-AND-BURN; TROPICAL FORESTS; LAND-USE; AGRICULTURE; SOIL;
DEFORESTATION; ALTERNATIVES; REGION; PERIOD; BRAZIL
AB This study examines the value of fallow ecosystem services in shifting cultivation, including hydrological externalities that may affect other farms. Using farm-level survey data from the Brazilian Amazon, I estimate a production function to assess the value of forest fallow and test whether it provides local externalities to agricultural production. Soil quality controls, instrumental variables, and spatial econometric approaches help address endogeneity issues. I use GIS data on external forest cover at the farm level and model the hydrological externality as an upstream-to-downstream process. The estimated parameters indicate that fallow contributes significantly to productivity both on farm and downstream. In addition, most farms allocate sufficient land to fallow, accounting for both the value of hydrological spillovers and the opportunity cost of land left out of cultivation. These results suggest that farming communities may have some self-interest in preserving forest cover locally-a finding that may bolster policy efforts aimed at conserving tropical forests for their global public goods. Published by Elsevier Inc.
C1 US EPA, Natl Ctr Environm Econ, Washington, DC 20460 USA.
RP Klemick, H (reprint author), US EPA, Natl Ctr Environm Econ, 1200 Penn Ave, NW 1809T, Washington, DC 20460 USA.
EM klemick.heather@epamail.epa.gov
NR 40
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Z9 13
U1 8
U2 48
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0095-0696
J9 J ENVIRON ECON MANAG
JI J.Environ.Econ.Manage.
PD JAN
PY 2011
VL 61
IS 1
BP 95
EP 106
DI 10.1016/j.jeem.2010.07.003
PG 12
WC Business; Economics; Environmental Studies
SC Business & Economics; Environmental Sciences & Ecology
GA 710VG
UT WOS:000286544500007
ER
PT J
AU He, F
Shaffer, ML
Li, XA
Rodriguez-Colon, S
Wolbrette, DL
Williams, R
Cascio, WE
Liao, DP
AF He, Fan
Shaffer, Michele L.
Li, Xian
Rodriguez-Colon, Sol
Wolbrette, Deborah L.
Williams, Ronald
Cascio, Wayne E.
Liao, Duanping
TI Individual-level PM2.5 exposure and the time course of impaired heart
rate variability: the APACR Study
SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
LA English
DT Article
DE particulate matter; fine particles; heart rate variability; autonomic
modulation; cardiovascular disease; personal nephelometry
ID PARTICULATE AIR-POLLUTION; CARDIAC AUTONOMIC CONTROL;
CORONARY-ARTERY-DISEASE; ENVIRONMENTAL EPIDEMIOLOGY;
CARDIOVASCULAR-DISEASE; CRITERIA POLLUTANTS; SUDDEN-DEATH; ASSOCIATION;
INFLAMMATION; POPULATION
AB In 106 community-dwelling middle-aged non-smokers we examined the time-course and the acute effects of fine particles (PM2.5) on heart rate variability (HRV), which measures cardiac autonomic modulation (CAM). Twenty-four hours beat-to-beat ECG data were visually examined. Artifacts and arrhythmic beats were removed. Normal beat-to-beat RR data were used to calculate HRV indices. Personal PM2.5 nephelometry was used to estimate 24-h individual-level real-time PM2.5 exposures. We use linear mixed-effects models to assess autocorrelation- and other major confounder-adjusted regression coefficients between 1-6 h moving averages of PM2.5 and HRV indices. The increases in preceding 1-6 h moving averages of PM2.5 was significantly associated with lower HF, LF, and SDNN, with the largest effect size at 4-6 h moving averages and smallest effects size at 1 h moving average. For example, a 10 mu g/m(3) increase in 1 and 6-h moving averages was associated with 0.027 and 0.068 ms(2) decrease in log-HF, respectively, and with 0.024 and 0.071 ms(2) decrease in log-LF, respectively, and with 0.81 and 1.75 ms decrease in SDNN, respectively (all P-values <0.05). PM2.5 exposures are associated with immediate impairment of CAM. With a time-course of within 6 h after elevated PM2.5 exposure, with the largest effects around 4-6 h. Journal of Exposure Science and Environmental Epidemiology (2011) 21, 65-73; doi: 10.1038/jes.2010.21; published online 7 April 2010
C1 [He, Fan; Shaffer, Michele L.; Li, Xian; Rodriguez-Colon, Sol; Liao, Duanping] Penn State Univ, Coll Med, Dept Publ Hlth Sci, Hershey, PA 17033 USA.
[Wolbrette, Deborah L.] Penn State Univ, Coll Med, Dept Med, Div Cardiol, Hershey, PA 17033 USA.
[Williams, Ronald] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Cascio, Wayne E.] E Carolina Univ, Brody Sch Med, Dept Cardiovasc Sci, Greenville, NC USA.
[Cascio, Wayne E.] E Carolina Univ, E Carolina Heart Inst, Greenville, NC USA.
RP Liao, DP (reprint author), Penn State Univ, Coll Med, Dept Publ Hlth Sci, 600 Centerview Dr,Suite 2200,A210, Hershey, PA 17033 USA.
EM dliao@psu.edu
FU NIEHS [1 R01 ES014010]
FX This study is funded by NIEHS (1 R01 ES014010). We thank Dr. David
Mortara of Mortara Instrument Inc., for providing the SuperECG software
for the analysis of the electrocardiographic data.
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PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1559-0631
EI 1559-064X
J9 J EXPO SCI ENV EPID
JI J. Expo. Sci. Environ. Epidemiol.
PD JAN-FEB
PY 2011
VL 21
IS 1
BP 65
EP 73
DI 10.1038/jes.2010.21
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 696PF
UT WOS:000285452900009
PM 20372190
ER
PT J
AU Mcbride, SJ
Norris, GA
Williams, RW
Neas, LM
AF Mcbride, Sandra J.
Norris, Gary A.
Williams, Ron W.
Neas, Lucas M.
TI Bayesian hierarchical modeling of cardiac response to particulate matter
exposure
SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
LA English
DT Article
DE empirical/statistical models; exposure modeling; environmental
monitoring; particulate matter; epidemiology
ID HEART-RATE-VARIABILITY; AIR-POLLUTION; PERSONAL EXPOSURE;
EPIDEMIOLOGY-EXPOSURE; SOURCE-APPORTIONMENT; DAILY MORTALITY; PM2.5
EXPOSURE; US CITIES; AMBIENT; ASSOCIATION
AB Studies have linked increased levels of particulate air pollution to decreased autonomic control, as measured by heart rate variability (HRV), particularly in susceptible populations such as the elderly. In this study, we use data obtained from the 1998 USEPA epidemiology-exposure longitudinal panel study of elderly adults in a Baltimore retirement home to examine the relationship between HRV and PM(2.5) personal exposure. We consider PM(2.5) personal exposure in the aggregate and personal exposure to the components of PM(2.5) as estimated in two ways using receptor models. We develop a Bayesian hierarchical model for HRV as a function of personal exposure to PM(2.5), which integrates HRV measurements and data obtained from personal, indoor and outdoor PM(2.5) monitoring and meteorological data. We found a strong relationship between decreased HRV (HF, LF, r-MSSD and SDNN) and total personal exposure to PM(2.5) at a lag of 1 day. Using personal exposure monitoring (PEM) apportionment results, we examined the relative importance of ambient and non-ambient personal PM(2.5) exposure to HRV and found the effect of internal non-ambient sources of PM(2.5) on HRV to be minimal. Using the PEM apportionment data, a consistent effect of soil at short time scales (lag 0) was found across all five HRV measures, and an effect of sulfate on HRV was seen for HF and r-MSSD at the moving average of lags 0 and 1 days. Modeling of ambient site apportionment data indicated effects of nitrate on HRV at lags of 1 day, and moving averages of days 0 and 1 and days 0-2 for all but the ratio LF/HF. Sulfate had an effect on HRV at a lag of 1 day for four HRV measures (HF, LF, r-MSSD, SDNN) and for LF/HF at a moving average of days 0-2. Journal of Exposure Science and Environmental Epidemiology (2011) 21, 74-91; doi: 10.1038/jes.2009.58; published online 30 December 2009
C1 [Williams, Ron W.] US EPA, Natl Exposure Res Lab, Acting Branch Chief, Exposure Measurements & Anal Branch, Res Triangle Pk, NC 27711 USA.
[Mcbride, Sandra J.] Duke Univ, Nicholas Sch Environm & Earth Sci, Durham, NC 27708 USA.
[Neas, Lucas M.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
RP Williams, RW (reprint author), US EPA, Natl Exposure Res Lab, Acting Branch Chief, Exposure Measurements & Anal Branch, MD-E205-04, Res Triangle Pk, NC 27711 USA.
EM Williams.Ronald@epamail.epa.gov
RI Neas, Lucas/J-9378-2012
FU US Environmental Protection Agency through its Office of Research and
Development [3D-5925-WATX, 4D-5895-WATX]
FX This paper is now being subjected to external peer review and has not
been cleared for publication by the US Environmental Protection Agency.
The US Environmental Protection Agency through its Office of Research
and Development funded and conducted the research described herein
through contract 3D-5925-WATX and 4D-5895-WATX to Dr. Sandra McBride.
Mention of trade names or commercial products does not constitute
endorsement or recommendation for use.
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PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1559-0631
J9 J EXPO SCI ENV EPID
JI J. Expo. Sci. Environ. Epidemiol.
PD JAN-FEB
PY 2011
VL 21
IS 1
BP 74
EP 91
DI 10.1038/jes.2009.58
PG 18
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 696PF
UT WOS:000285452900010
PM 20040931
ER
PT J
AU George, BJ
Mccurdy, T
AF George, Barbara Jane
Mccurdy, Thomas
TI Investigating the American Time Use Survey from an exposure modeling
perspective
SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
LA English
DT Article
DE American Time Use Survey; Bureau of Labor Statistics; time use; travel;
exposure modeling
ID POPULATION EXPOSURE; CARBON-MONOXIDE; AMBIENT; PARTICLES; EMISSIONS;
MATTER; DIARY
AB This paper describes an evaluation of the US Bureau of Labor Statistics' American Time Use Survey (ATUS) for potential use in modeling human exposures to environmental pollutants. The ATUS is a large, on-going, cross-sectional survey of where Americans spend time and what activities they undertake in those locations. The data are reported as a series of sequential activities over a 24-h time period-a "diary day"-starting at 0400 hours. Between 12,000 and 13,000 surveys are obtained each year and the Bureau has plans to continue ATUS for the foreseeable future. The ATUS already has about 73,000 diary days of data, more than twice as many as that which currently exists in the US Environmental Protection Agency's (EPA) "Consolidated Human Activity Database" (CHAD) that the Agency uses for exposure modeling purposes. There are limitations for using ATUS in modeling human exposures to environmental pollutants. The ATUS does not report the location for a number of activities regarded as "personal." For 2006, personal activities with missing location information totaled 572 min/day, on average, for survey participants: about 40% of their day. Another limitation is that ATUS does not distinguish between indoor and outdoor activities at home, two of the traditional locational demarcations used in human exposure modeling. This lack of information affects exposure estimates to both indoor and outdoor air pollutants and potentially affects non-dietary ingestion estimates for children, which can vary widely depending on whether or not a child is indoors. Finally, a detailed analysis of the work travel activity in a subsample from ATUS 2006 indicates that the coding scheme is not fully consistent with a CHAD-based exposure modeling approach. For ATUS respondents in this subsample who reported work as an activity, roughly 48% of their days were missing work travel at one or both ends of the work shift or reported within work-shift travel inconsistently. An extensive effort would be needed to recode work travel data from ATUS for EPA's exposure modeling purposes. Journal of Exposure Science and Environmental Epidemiology (2011) 21, 92-105; doi: 10.1038/jes.2009.60; published online 30 December 2009
C1 [George, Barbara Jane; Mccurdy, Thomas] US EPA, Natl Exposure Res Lab, Human Exposure & Atmospher Sci Div, Exposure Modeling Res Branch, Res Triangle Pk, NC 27711 USA.
RP George, BJ (reprint author), US EPA, Natl Exposure Res Lab, Human Exposure & Atmospher Sci Div, Exposure Modeling Res Branch, Res Triangle Pk, NC 27711 USA.
EM george.bj@epa.gov
FU US government at taxpayer's expense
FX This paper has been subject to EPA's peer-review process and has been
approved for publication. Mention of registered trade names does not
constitute Agency endorsement of the product. The authors have no
financial interests in the outcome of this study; it was funded solely
by the US government at taxpayer's expense.
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PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1559-0631
J9 J EXPO SCI ENV EPID
JI J. Expo. Sci. Environ. Epidemiol.
PD JAN-FEB
PY 2011
VL 21
IS 1
BP 92
EP 105
DI 10.1038/jes.2009.60
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 696PF
UT WOS:000285452900011
PM 20040930
ER
PT J
AU Lemen, RA
Anderson, H
Bailar, JC
Bingham, E
Castleman, B
Frank, AL
Huff, J
Ladou, J
Melius, J
Monforton, C
Robbins, A
Teitelbaum, DT
Welch, LS
AF Lemen, Richard A.
Anderson, Henry
Bailar, John C.
Bingham, Eula
Castleman, Barry
Frank, Arthur L.
Huff, James
Ladou, Joseph
Melius, James
Monforton, Celeste
Robbins, Anthony
Teitelbaum, Daniel Thau
Welch, Laura S.
TI Exposure science will not increase protection of workers from
asbestos-caused diseases: NIOSH fails to provide needed public health
action and leadership
SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
LA English
DT Letter
ID CHRYSOTILE ASBESTOS; GLOBAL BAN
C1 [Lemen, Richard A.] US PHS, Canton, GA USA.
[Lemen, Richard A.] NIOSH, Canton, GA USA.
[Anderson, Henry] Wisconsin Div Publ Hlth, Madison, WI USA.
[Bailar, John C.] Univ Chicago, Chicago, IL 60637 USA.
[Bailar, John C.] Natl Acad, Chicago, IL USA.
[Bingham, Eula] Univ Cincinnati, Cincinnati, OH USA.
[Frank, Arthur L.] Drexel Univ, Sch Publ Hlth, Philadelphia, PA 19104 USA.
[Huff, James] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
[Ladou, Joseph] Univ Calif San Francisco, Div Occupat & Environm Med, San Francisco, CA 94143 USA.
[Melius, James] NYS Laborers Hlth & Safety Fund, Albany, NY USA.
[Monforton, Celeste] Amer Publ Hlth Assoc, Occupat Hlth & Safety Sect, Washington, DC USA.
[Robbins, Anthony] Tufts Univ, Sch Med, Boston, MA 02111 USA.
[Teitelbaum, Daniel Thau] Colorado Sch Publ Hlth, Denver, CO USA.
[Welch, Laura S.] George Washington Univ, Sch Publ Hlth & Hlth Serv, Washington, DC USA.
EM rlemen421@yahoo.com
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PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1559-0631
J9 J EXPO SCI ENV EPID
JI J. Expo. Sci. Environ. Epidemiol.
PD JAN-FEB
PY 2011
VL 21
IS 1
BP 114
EP 115
DI 10.1038/jes.2010.53
PG 2
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 696PF
UT WOS:000285452900013
PM 21170057
ER
PT J
AU Bezemer, GFG
Bauer, SM
Oberdorster, G
Breysse, PN
Pieters, RHH
Georas, SN
Williams, MA
AF Bezemer, Gillina F. G.
Bauer, Stephen M.
Oberdoerster, Guenter
Breysse, Patrick N.
Pieters, Raymond H. H.
Georas, Steve N.
Williams, Marc A.
TI Activation of Pulmonary Dendritic Cells and Th2-Type Inflammatory
Responses on Instillation of Engineered, Environmental Diesel Emission
Source or Ambient Air Pollutant Particles in vivo
SO JOURNAL OF INNATE IMMUNITY
LA English
DT Article
DE Innate immunity; Allergic immunity; Dendritic cell; Lung; Inflammation;
Immunotoxicology; Toxicology; Particulate matter; Nanoparticles
ID BRONCHIAL EPITHELIAL-CELLS; FINE PARTICULATE MATTER; TIGHT JUNCTION
PROTEINS; CD4(+) T-CELLS; EXHAUST PARTICLES; OXIDATIVE STRESS; INHALED
ANTIGEN; ALLERGIC INFLAMMATION; METABOLIC PATHWAYS; ADJUVANT ACTIVITY
AB The biological effects of acute particulate air pollution exposure in host innate immunity remain obscure and have relied largely on in vitro models. We hypothesized that single acute exposure to ambient or engineered particulate matter (PM) in the absence of other secondary stimuli would activate lung dendritic cells (DC) in vivo and provide information on the early immunological events of PM exposure and DC activation in a mouse model naive to prior PM exposure. Activation of purified lung DC was studied following oropharyngeal instillation of ambient particulate matter (APM). We compared the effects of APM exposure with that of diesel-enriched PM (DEP), carbon black particles (CBP) and silver nanoparticles (AgP). We found that PM species induced variable cellular infiltration in the lungs and only APM exposure induced eosinophilic infiltration. Both APM and DEP activated pulmonary DC and promoted a Th2-type cytokine response from naive CD4+T cells ex vivo. Cultures of primary peribronchial lymph node cells from mice exposed to APM and DEP also displayed a Th2-type immune response ex vivo. We conclude that exposure of the lower airway to various PM species induces differential immunological responses and immunomodulation of DC subsets. Environmental APM and DEP activated DC in vivo and provoked a Th2 response ex vivo. By contrast, CBP and AgP induced altered lung tissue barrier integrity but failed to stimulate CD4+T cells as effectively. Our work suggests that respirable pollutants activate the innate immune response with enhanced DC activation, pulmonary inflammation and Th2-immune responsiveness. Copyright (c) 2010 S. Karger AG, Basel
C1 [Bezemer, Gillina F. G.; Pieters, Raymond H. H.] Univ Utrecht, Immunotoxicol Inst Risk Assessment Sci, Utrecht, Netherlands.
[Bauer, Stephen M.; Georas, Steve N.; Williams, Marc A.] Univ Rochester, Sch Med & Dent, Div Pulm & Crit Care Med, Rochester, NY USA.
[Oberdoerster, Guenter] Univ Rochester, Sch Med & Dent, Div Resp Biol & Toxicol, Rochester, NY USA.
[Georas, Steve N.; Williams, Marc A.] Univ Rochester, Sch Med & Dent, Lung Biol & Dis Program, Rochester, NY USA.
[Oberdoerster, Guenter; Georas, Steve N.; Williams, Marc A.] Univ Rochester, Sch Med & Dent, Dept Environm Med, Rochester, NY USA.
[Breysse, Patrick N.] Johns Hopkins Univ, Dept Environm Hlth Sci, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA.
RP Williams, MA (reprint author), US EPA, NHEERL, Environm Publ Hlth Div, Cardiopulm & Immunotoxicol Branch,Off Res & Dev, Res Triangle Pk, NC 27711 USA.
EM Williams.marc@epa.gov
FU NIH/NIEHS [P30 ES03819, P30 ES001247]; US Environmental Protection
Agency [R82672401]; National Institute for Environmental Health Sciences
[PO1 ES09606]; University of Rochester US - EPA Particulate Matter
Center [RD83241501]; University of Rochester NIEHS Center [P30 ESO1247];
Department of Medicine, University of Rochester School of Medicine and
Dentistry; Dutch Asthma Fund; United States Environmental Protection
Agency [R82672401]
FX The authors would like to thank Nancy Corson and Pamela Mercer for their
excellent technical assistance with mouse exposure experiments and BALF
chemistry measurements. This project was funded in part by NIH/NIEHS
Pilot Project Grants P30 ES03819 and P30 ES001247 (both awarded to
M.A.W.), The US Environmental Protection Agency (grant No. R82672401,
awarded to P.B.) and the National Institute for Environmental Health
Sciences (grant No. PO1 ES09606, awarded to P.B.), The University of
Rochester US - EPA Particulate Matter Center (grant No. RD83241501) and
The University of Rochester NIEHS Center (grant No. P30 ESO1247), The
Department of Medicine, University of Rochester School of Medicine and
Dentistry and the Dutch Asthma Fund (awarded to G.F.G.B. and R.H.H.P.).
Please note that the research described in this article has been funded
in part by the United States Environmental Protection Agency through
grant agreement R82672401 awarded to Dr. Patrick Breysse and has not
been subjected to the Agency's peer and policy review and thus does not
necessarily reflect the views of the Agency and no official endorsement
should be inferred or concluded from this work. In addition, the senior
author of this work, Dr. Marc A. Williams, performed the studies and
data analyses reported herein while entirely employed by the University
of Rochester and School of Medicine, Rochester, N.Y., USA. Although the
corresponding address of Dr. Williams is provided as The US
Environmental Protection Agency, Research Triangle Park, N.C., USA, none
of the work whatsoever was conducted at that Agency and thus the
research data, discussion and conclusions reported in this article do
not necessarily reflect the views of the Agency at all and no official
endorsement should be inferred or concluded from this work.
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U2 10
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1662-811X
J9 J INNATE IMMUN
JI J. Innate Immun.
PY 2011
VL 3
IS 2
BP 150
EP 166
DI 10.1159/000321725
PG 17
WC Immunology
SC Immunology
GA 724EU
UT WOS:000287559700006
PM 21099199
ER
PT J
AU Yokel, RA
MacPhail, RC
AF Yokel, Robert A.
MacPhail, Robert C.
TI Engineered nanomaterials: exposures, hazards, and risk prevention
SO JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY
LA English
DT Review
ID MULTIWALLED CARBON NANOTUBES; FILTERING-FACEPIECE RESPIRATORS; CERIUM
OXIDE NANOPARTICLES; POTENTIAL INHALATION EXPOSURE; BRONCHIAL
EPITHELIAL-CELLS; ASSESSMENT TECHNIQUE NEAT; CULTURED BEAS-2B CELLS;
CENTRAL-NERVOUS-SYSTEM; TITANIUM-DIOXIDE; IN-VITRO
AB Nanotechnology presents the possibility of revolutionizing many aspects of our lives. People in many settings (academic, small and large industrial, and the general public in industrialized nations) are either developing or using engineered nanomaterials (ENMs) or ENM-containing products. However, our understanding of the occupational, health and safety aspects of ENMs is still in its formative stage. A survey of the literature indicates the available information is incomplete, many of the early findings have not been independently verified, and some may have been over-interpreted. This review describes ENMs briefly, their application, the ENM workforce, the major routes of human exposure, some examples of uptake and adverse effects, what little has been reported on occupational exposure assessment, and approaches to minimize exposure and health hazards. These latter approaches include engineering controls such as fume hoods and personal protective equipment. Results showing the effectiveness - or lack thereof - of some of these controls are also included. This review is presented in the context of the Risk Assessment/Risk Management framework, as a paradigm to systematically work through issues regarding human health hazards of ENMs. Examples are discussed of current knowledge of nanoscale materials for each component of the Risk Assessment/Risk Management framework. Given the notable lack of information, current recommendations to minimize exposure and hazards are largely based on common sense, knowledge by analogy to ultrafine material toxicity, and general health and safety recommendations. This review may serve as an overview for health and safety personnel, management, and ENM workers to establish and maintain a safe work environment. Small start-up companies and research institutions with limited personnel or expertise in nanotechnology health and safety issues may find this review particularly useful.
C1 [Yokel, Robert A.] Univ Kentucky, Coll Pharm, Dept Pharmaceut Sci, Lexington, KY 40536 USA.
[Yokel, Robert A.] Univ Kentucky, Grad Ctr Toxicol, Lexington, KY 40536 USA.
[MacPhail, Robert C.] US EPA, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
RP Yokel, RA (reprint author), Univ Kentucky, Coll Pharm, Dept Pharmaceut Sci, Lexington, KY 40536 USA.
EM ryokel@email.uky.edu
FU US EPA STAR [RD-833772]
FX The authors gratefully acknowledge the financial support for nanoscale
research provided by US EPA STAR Grant RD-833772. The authors thank Matt
H. Hazzard and Robin L. Jones, University of Kentucky Teaching &
Academic Support Center, for preparing Figures 1, 2, 3, 4, and 5 and
Drs. Ronald E. Shaffer, NIOSH, and William K. Boyes, EPA, for their
helpful comments on a prior version of this review, and an anonymous
journal reviewer whose extensive comments surely improved this
manuscript. This manuscript has been reviewed by the National Health and
Environmental Effects Research Laboratory and approved for publication.
Approval does not signify that the contents reflect the views of the
Agency, nor does mention of trade names or commercial products
constitute endorsement or recommendation for use.
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PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1745-6673
J9 J OCCUP MED TOXICOL
JI J. Occup. Med. Toxicol.
PY 2011
VL 6
AR 7
DI 10.1186/1745-6673-6-7
PG 27
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA V27LX
UT WOS:000208615800007
PM 21418643
ER
PT J
AU Cao, ZY
Shafer, TJ
Murray, TF
AF Cao, Zhengyu
Shafer, Timothy J.
Murray, Thomas F.
TI Mechanisms of Pyrethroid Insecticide-Induced Stimulation of Calcium
Influx in Neocortical Neurons
SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
LA English
DT Article
ID RAT-BRAIN; HIPPOCAMPAL-NEURONS; SODIUM-CHANNELS; XENOPUS OOCYTES; ION
CHANNELS; DELTAMETHRIN; ALLETHRIN; TOXICITY; CELLS; PHOSPHORYLATION
AB Pyrethroid insecticides bind to voltage-gated sodium channels (VGSCs) and modify their gating kinetics, thereby disrupting neuronal function. Pyrethroids have also been reported to alter the function of other channel types, including activation of voltage-gated calcium channels. Therefore, the present study compared the ability of 11 structurally diverse pyrethroids to evoke Ca2+ influx in primary cultures of mouse neocortical neurons. Nine pyrethroids (tefluthrin, deltamethrin, lambda-cyhalothrin, beta-cyfluthrin, esfenvalerate, S-bioallethrin, fenpropathrin, cypermethrin, and bifenthrin) produced concentration-dependent elevations in intracellular calcium concentration ([Ca2+](i)) in neocortical neurons. Permethrin and resmethrin were without effect on [Ca2+](i). These pyrethroids displayed a range of efficacies on Ca2+ influx; however, the EC50 values for active pyrethroids all were within one order of magnitude. Tetrodotoxin blocked increases in [Ca2+](i) caused by all nine active pyrethroids, indicating that the effects depended on VGSC activation. The pathways for deltamethrin-and tefluthrin-induced Ca2+ influx include N-methyl-D-aspartic acid receptors, L-type Ca2+ channels, and reverse mode of operation of the Na+/Ca2+ exchanger inasmuch as antagonists of these sites blocked deltamethrin-induced Ca2+ influx. These data demonstrate that pyrethroids stimulate Ca2+ entry into neurons subsequent to their actions on VGSCs.
C1 [Cao, Zhengyu; Murray, Thomas F.] Creighton Univ, Sch Med, Dept Pharmacol, Omaha, NE 68178 USA.
[Shafer, Timothy J.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Integrated Syst Toxicol Div, Res Triangle Pk, NC 27711 USA.
RP Murray, TF (reprint author), Creighton Univ, Sch Med, Dept Pharmacol, Omaha, NE 68178 USA.
EM tfmurray@creighton.edu
RI cao, zhengyu/G-2527-2012; Shafer, Timothy/D-6243-2013;
OI Shafer, Timothy/0000-0002-8069-9987
FU U.S. Environmental Protection Agency [PR-RT-08-00545]; National
Institutes of Health National Center for Research Resources
[G20RR024001]
FX This work was supported by the U.S. Environmental Protection Agency
[Grant PR-RT-08-00545] (to T.F.M.), and the National Institutes of
Health National Center for Research Resources [Grant G20RR024001].
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PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0022-3565
J9 J PHARMACOL EXP THER
JI J. Pharmacol. Exp. Ther.
PD JAN
PY 2011
VL 336
IS 1
BP 197
EP 205
DI 10.1124/jpet.110.171850
PG 9
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 694YS
UT WOS:000285338400023
PM 20881019
ER
PT J
AU Huang, YCT
Karoly, ED
Dailey, LA
Schmitt, MT
Silbajoris, R
Graff, DW
Devlin, RB
AF Huang, Yuh-Chin T.
Karoly, Edward D.
Dailey, Lisa A.
Schmitt, Michael T.
Silbajoris, Robert
Graff, Donald W.
Devlin, Robert B.
TI COMPARISON OF GENE EXPRESSION PROFILES INDUCED BY COARSE, FINE, AND
ULTRAFINE PARTICULATE MATTER
SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
LA English
DT Article
ID BRONCHIAL EPITHELIAL-CELLS; AIR-POLLUTION PARTICLES; OXIDATIVE
DNA-DAMAGE; LONG-TERM EXPOSURE; AMBIENT AIR; SIZE FRACTIONS; PULMONARY
INFLAMMATION; LUNG-CANCER; IN-VITRO; MORTALITY
AB Coarse, fine, and ultrafine particulate matter (PM) fractions possess different physical properties and chemical compositions and may produce different adverse health effects. Studies were undertaken to determine whether or not gene expression patterns may be used to discriminate among the three size fractions. Airway epithelial cells obtained from 6 normal individuals were exposed to Chapel Hill coarse, fine or ultrafine PM (250 mu g/ml) for 6 and 24 h (n = 3 different individuals each). RNA was isolated and hybridized to Affymetrix cDNA microarrays. Significant genes were identified and mapped to canonical pathways. Expression of selected genes was confirmed by reverse-transcription polymerase chain reaction (RT-PCR). The numbers of genes altered by coarse, fine, and ultrafine PM increased from 0, 6, and 17 at 6 h to 1281, 302, and 455 at 24 h, respectively. The NRF2-mediated oxidative stress response, cell cycle:G2/M DNA damage checkpoint regulation, and mitotic roles of polo-like kinase were the top three pathways altered by all three fractions. Fine and ultrafine PM displayed more similar gene expression patterns. One example was the increased expression of metallothionein isoforms, reflecting the higher zinc content associated with fine and ultrafine fractions. A set of 10 genes was identified that could discriminate fine and ultrafine PM from coarse PM. These results indicate that common properties shared by the three size fractions as well as size-specific factors, e. g., compositions, may determine the effects on gene expression. Genomic markers may be used to discriminate coarse from fine and ultrafine PM.
C1 [Huang, Yuh-Chin T.] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA.
[Karoly, Edward D.; Dailey, Lisa A.; Schmitt, Michael T.; Silbajoris, Robert; Graff, Donald W.; Devlin, Robert B.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Huang, YCT (reprint author), Duke Univ, Med Ctr, Dept Med, 330 Trent Dr,Hanes House,Room 105-B, Durham, NC 27710 USA.
EM huang002@mc.duke.edu
NR 50
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U1 3
U2 24
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1528-7394
J9 J TOXICOL ENV HEAL A
JI J. Toxicol. Env. Health Part A
PY 2011
VL 74
IS 5
BP 296
EP 312
DI 10.1080/15287394.2010.516238
PG 17
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 734WQ
UT WOS:000288372600002
PM 21240730
ER
PT J
AU Saxena, RK
McClure, ME
Hays, MD
Green, FHY
McPhee, LJ
Vallyathan, V
Gilmour, MI
AF Saxena, Rajiv K.
McClure, Michael E.
Hays, Michael D.
Green, Francis H. Y.
McPhee, Laura J.
Vallyathan, V.
Gilmour, M. Ian
TI Quantitative Assessment of Elemental Carbon In The Lungs of Never
Smokers, Cigarette Smokers, and Coal Miners
SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
LA English
DT Article
ID DIESEL EXHAUST PARTICLES; PARTICULATE MATTER; EPITHELIAL-CELLS; BLACK;
WORKERS; CANCER; CARCINOGEN; EXPOSURE; DISEASE; TOBACCO
AB Inhalation exposure to particulates such as cigarette smoke and coal dust is known to contribute to the development of chronic lung disease. The purpose of this study was to estimate the amount of elemental carbon (EC) deposits from autopsied lung samples from cigarette smokers, miners, and control subjects and explore the relationship between EC level, exposure history, and the extent of chronic lung disease. The samples comprised three subgroups representing never smokers (8), chronic cigarette smokers (26), and coal miners (6). Following the dissolution of lung tissue, the extracted EC residue was quantified using a thermal-optical transmission (TOT) carbon analyzer. Mean EC levels in the lungs of the control group were 56.68 +/- 24.86 (SD) g/g dry lung weight. Respective mean EC values in lung samples from the smokers and coal miners were 449.56 +/- 320.3 g/g and 6678.2 +/- 6162 g/g. These values were significantly higher than those obtained from the never-smoker group. EC levels in the lung and pack-years of cigarette smoking correlated significantly, as did EC levels and the severity of small airway disease. This study provides one of the first quantitative assessments of EC in human lungs from populations at high relative risk for the development of chronic lung disease.
C1 [Gilmour, M. Ian] US EPA, Cardiopulmonary & Immunotoxicol Branch, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Saxena, Rajiv K.] Jawaharlal Nehru Univ, Sch Life Sci, New Delhi 110067, India.
[McClure, Michael E.; Hays, Michael D.] US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
[Green, Francis H. Y.; McPhee, Laura J.] Univ Calgary, Fac Med, Calgary, AB, Canada.
[Vallyathan, V.] NIOSH, Ctr Dis Control & Prevent, Morgantown, WV USA.
RP Gilmour, MI (reprint author), US EPA, Cardiopulmonary & Immunotoxicol Branch, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, MD B143-04, Res Triangle Pk, NC 27711 USA.
EM gilmour.ian@epa.gov
RI Hays, Michael/E-6801-2013
OI Hays, Michael/0000-0002-4029-8660
FU U.S. National Research Council; Alberta Lung Association; Health Canada;
U.S. National Institute of Occupational Safety and Health
FX We remember our dear friend and colleague Dr. V. Vallyathan, who passed
away in an automobile accident during the preparation of this article.
R. K. Saxena was supported through a senior fellowship of the U.S.
National Research Council. F. H. Y. Green was supported through a grant
from the Alberta Lung Association, Health Canada, and a contract with
the U.S. National Institute of Occupational Safety and Health. This
article has been reviewed by the National Health and Environmental
Effects Research Laboratory, U. S. Environmental Protection Agency, and
approved for publication. Approval does not signify that the contents
necessarily reflect the views and policies of the agency, nor does the
mention of trade names or commercial products constitute endorsement or
recommendation for use.
NR 32
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U1 0
U2 4
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1528-7394
J9 J TOXICOL ENV HEAL A
JI J. Toxicol. Env. Health Part A
PY 2011
VL 74
IS 11
BP 706
EP 715
AR PII 936100557
DI 10.1080/15287394.2011.556059
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 751KB
UT WOS:000289614900002
PM 21480045
ER
PT J
AU Zeidler-Erdely, PC
Battelli, LA
Salmen-Muniz, R
Li, Z
Erdely, A
Kashon, ML
Simeonova, PP
Antonini, JM
AF Zeidler-Erdely, Patti C.
Battelli, Lori A.
Salmen-Muniz, Rebecca
Li, Zheng
Erdely, Aaron
Kashon, Michael L.
Simeonova, Petia P.
Antonini, James M.
TI Lung Tumor Production and Tissue Metal Distribution After Exposure to
Manual Metal ARC-Stainless Steel Welding Fume in A/J and C57BL/6J Mice
SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
LA English
DT Article
ID FREE-RADICAL PRODUCTION; MOUSE LUNG; BACTERIAL-INFECTION; DEFENSE
RESPONSES; SUSCEPTIBLE A/J; TOBACCO-SMOKE; II CELL; CANCER;
INFLAMMATION; PARTICLES
AB Stainless steel welding produces fumes that contain carcinogenic metals. Therefore, welders may be at risk for the development of lung cancer, but animal data are inadequate in this regard. Our main objective was to examine lung tumor production and histopathological alterations in lung-tumor-susceptible (A/J) and -resistant C57BL/6J (B6) mice exposed to manual metal arc-stainless steel (MMA-SS) welding fume. Male mice were exposed to vehicle or MMA-SS welding fume (20 mg/kg) by pharyngeal aspiration once per month for 4 mo. At 78 wk postexposure, gross tumor counts and histopathological changes were assessed and metal analysis was done on extrapulmonary tissue (aorta, heart, kidney, and liver). At 78 wk postexposure, gross lung tumor multiplicity and incidence were unremarkable in mice exposed to MMA-SS welding fume. Histopathology revealed that only the exposed A/J mice contained minimal amounts of MMA-SS welding fume in the lung and statistically increased lymphoid infiltrates and alveolar macrophages. A significant increase in tumor multiplicity in the A/J strain was observed at 78 wk. Metal analysis of extrapulmonary tissue showed that only the MMA-SS-exposed A/J mice had elevated levels of Cr, Cu, Mn, and Zn in kidney and Cr in liver. In conclusion, this study further supports that MMA-SS welding fume does not produce a significant tumorigenic response in an animal model, but may induce a chronic lung immune response. In addition, long-term extrapulmonary tissue alterations in metals in the susceptible A/J mouse suggest that the adverse effects of this fume might be cumulative.
C1 [Zeidler-Erdely, Patti C.; Battelli, Lori A.; Antonini, James M.] NIOSH, Hlth Effects Lab Div, Pathol & Physiol Res Branch, Morgantown, WV 26505 USA.
[Salmen-Muniz, Rebecca; Erdely, Aaron; Simeonova, Petia P.] NIOSH, Hlth Effects Lab Div, Toxicol & Mol Biol Branch, Morgantown, WV 26505 USA.
[Salmen-Muniz, Rebecca; Erdely, Aaron] NIOSH, Hlth Effects Lab Div, Lab Occupat Cardiovasc Toxicol, Morgantown, WV 26505 USA.
[Kashon, Michael L.] NIOSH, Hlth Effects Lab Div, Biostat & Epidemiol Branch, Morgantown, WV 26505 USA.
[Li, Zheng] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
RP Zeidler-Erdely, PC (reprint author), NIOSH, Hlth Effects Lab Div, Pathol & Physiol Res Branch, 1095 Willowdale Rd M-S L2015, Morgantown, WV 26505 USA.
EM PErdely@cdc.gov
RI Erdely, Aaron/A-3518-2013
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U2 4
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1528-7394
J9 J TOXICOL ENV HEAL A
JI J. Toxicol. Env. Health Part A
PY 2011
VL 74
IS 11
BP 728
EP 736
AR PII 936098529
DI 10.1080/15287394.2011.556063
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 751KB
UT WOS:000289614900004
PM 21480047
ER
PT J
AU Padilla-Carlin, DJ
Schladweiler, MCJ
Shannahan, JH
Kodavanti, UP
Nyska, A
Burgoon, LD
Gavett, SH
AF Padilla-Carlin, Danielle J.
Schladweiler, Mette C. J.
Shannahan, Jonathan H.
Kodavanti, Urmila P.
Nyska, Abraham
Burgoon, Lyle D.
Gavett, Stephen H.
TI PULMONARY INFLAMMATORY AND FIBROTIC RESPONSES IN FISCHER 344 RATS AFTER
INTRATRACHEAL INSTILLATION EXPOSURE TO LIBBY AMPHIBOLE
SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
LA English
DT Article
ID ASBESTOS EXPOSURE; BRONCHOALVEOLAR LAVAGE; CROCIDOLITE ASBESTOS;
TITANIUM-DIOXIDE; LUNG INJURY; INHALATION; EXPRESSION; MONTANA; FIBERS;
DISEASES
AB Increased incidences of asbestosis have been reported in workers from Libby, MT, associated with exposures to amphibole-contaminated vermiculite. In this study pulmonary and histopathological changes were investigated following Libby amphibole (LA) exposure in a rat model. Rat respirable fractions of LA and amosite (aerodynamic diameter <2.5 mu m) were prepared by water elutriation. Male F344 rats were exposed to single doses of either saline (SAL), amosite (0.65 mg/rat), or LA (0.65 or 6.5 mg/rat) by intratracheal instillation. At times from 1 d to 3 mo after exposure, bronchoalveolar lavage (BAL) was performed and right and left lungs were removed for reverse-transcription polymerase chain reaction (RT-PCR) and histopathological analysis, respectively. Data indicated that 0.65 mg amosite resulted in a higher degree of pulmonary injury, inflammation, and fibrotic events than LA at the same mass dose. Exposure to either amosite or high dose LA resulted in higher levels of cellular permeability and injury, inflammatory enzymes, and iron binding proteins in both BAL fluid and lung tissue at most time points when compared to SAL controls. However, mRNA expression for some growth factors (e. g., platelet-derived growth factor [PDGF]-A and transforming growth factor [TGF]-1 beta), which contribute to fibrosis, were downregulated at several time points. Furthermore, histopathological examination showed notable thickening of interstitial areas surrounding the alveolar ducts and terminal bronchioles. On a mass dose basis, amosite produced a greater acute and persistent lung injury for at least 3 mo after exposure. However, further testing and analysis of LA are needed with regard to the dose metric to fully evaluate its potential fibrogenicity and carcinogenicity.
C1 [Schladweiler, Mette C. J.; Kodavanti, Urmila P.; Gavett, Stephen H.] US EPA, Cardiopulm & Immunotoxicol Branch, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Res Triangle Pk, NC 27711 USA.
[Padilla-Carlin, Danielle J.; Shannahan, Jonathan H.] UNC Sch Med, Curriculum Toxicol, Chapel Hill, NC USA.
[Burgoon, Lyle D.] US EPA, Res Cores Unit, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Nyska, Abraham] Tel Aviv Univ, Sackler Sch Med, Timrat, Israel.
RP Gavett, SH (reprint author), US EPA, Cardiopulm & Immunotoxicol Branch, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Res Triangle Pk, NC 27711 USA.
EM Gavett.stephen@epa.gov
OI Burgoon, Lyle/0000-0003-4977-5352
FU U.S. EPA/UNC [CR 833237]; Curriculum in Toxicology, University of North
Carolina at Chapel Hill
FX This work was supported by the U.S. EPA/UNC Toxicology Research Program,
Training Agreement CR 833237, with the Curriculum in Toxicology,
University of North Carolina at Chapel Hill. The authors thank Debora
Andrews, Rick Jaskot, and Judy Richards for their technical assistance.
We thank Drs. Gary Hatch and Aimen Farraj, and members of the Libby
Action Plan working group for their review of the article.
NR 44
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PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1528-7394
J9 J TOXICOL ENV HEAL A
JI J. Toxicol. Env. Health Part A
PY 2011
VL 74
IS 17
BP 1111
EP 1132
DI 10.1080/15287394.2011.586940
PG 22
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 820KO
UT WOS:000294904800001
PM 21797767
ER
PT J
AU Gwinn, MR
AF Gwinn, Maureen R.
TI MULTIPLE MODES OF ACTION OF ASBESTOS AND RELATED MINERAL FIBERS
SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
LA English
DT Editorial Material
C1 US EPA, EICG, NCEA, ORD, Washington, DC 20460 USA.
RP Gwinn, MR (reprint author), US EPA, EICG, NCEA, ORD, 1200 Penn Ave NW,Mail Code 8623-P, Washington, DC 20460 USA.
EM gwinn.maureen@epamail.epa.gov
NR 0
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U1 0
U2 3
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1093-7404
J9 J TOXICOL ENV HEAL B
JI J. Toxicol. Env. Health-Pt b-Crit. Rev.
PY 2011
VL 14
IS 1-4
SI SI
BP 1
EP 2
DI 10.1080/10937404.2011.556044
PG 2
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 757LY
UT WOS:000290087900001
PM 21534083
ER
PT J
AU Aust, AE
Cook, PM
Dodson, RF
AF Aust, Ann E.
Cook, Philip M.
Dodson, Ronald F.
TI MORPHOLOGICAL AND CHEMICAL MECHANISMS OF ELONGATED MINERAL PARTICLE
TOXICITIES
SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
LA English
DT Review
ID LUNG EPITHELIAL-CELLS; SINGLE-STRAND BREAKS; PLEURAL MESOTHELIAL CELLS;
NITRIC-OXIDE SYNTHASE; WALL CARBON NANOTUBE; CROCIDOLITE ASBESTOS;
CHRYSOTILE ASBESTOS; ALVEOLAR MACROPHAGES; IRON MOBILIZATION; PARIETAL
PLEURA
AB Much of our understanding regarding the mechanisms for induction of disease following inhalation of respirable elongated mineral particles (REMP) is based on studies involving the biological effects of asbestos fibers. The factors governing the disease potential of an exposure include duration and frequency of exposures; tissue-specific dose over time; impacts on dose persistence from in vivo REMP dissolution, comminution, and clearance; individual susceptibility; and the mineral type and surface characteristics. The mechanisms associated with asbestos particle toxicity involve two facets for each particle's contribution: (1) the physical features of the inhaled REMP, which include width, length, aspect ratio, and effective surface area available for cell contact; and (2) the surface chemical composition and reactivity of the individual fiber/elongated particle. Studies in cell-free systems and with cultured cells suggest an important way in which REMP from asbestos damage cellular molecules or influence cellular processes. This may involve an unfortunate combination of the ability of REMP to chemically generate potentially damaging reactive oxygen species, through surface iron, and the interaction of the unique surfaces with cell membranes to trigger membrane receptor activation. Together these events appear to lead to a cascade of cellular events, including the production of damaging reactive nitrogen species, which may contribute to the disease process. Thus, there is a need to be more cognizant of the potential impact that the total surface area of REMP contributes to the generation of events resulting in pathological changes in biological systems. The information presented has applicability to inhaled dusts, in general, and specifically to respirable elongated mineral particles.
C1 [Dodson, Ronald F.] Dodson Environm Consulting Inc, Tyler, TX 75701 USA.
[Dodson, Ronald F.] ERI Environm Consulting Inc, Tyler, TX USA.
[Aust, Ann E.] Utah State Univ, Dept Chem & Biochem, Huachuca City, AZ USA.
[Cook, Philip M.] US EPA, NHEERL, Mid Continent Ecol Div, Duluth, MN USA.
RP Dodson, RF (reprint author), Dodson Environm Consulting Inc, 2026 Republ Dr,Suite A, Tyler, TX 75701 USA.
EM ron@ericonsulting.com
NR 163
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U1 3
U2 13
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1093-7404
EI 1521-6950
J9 J TOXICOL ENV HEAL B
JI J. Toxicol. Env. Health-Pt b-Crit. Rev.
PY 2011
VL 14
IS 1-4
SI SI
BP 40
EP 75
DI 10.1080/10937404.2011.556046
PG 36
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 757LY
UT WOS:000290087900003
PM 21534085
ER
PT J
AU Davis, MJ
Janke, R
AF Davis, Michael J.
Janke, Robert
TI Patterns in Potential Impacts Associated with Contamination Events in
Water Distribution Systems
SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT-ASCE
LA English
DT Article
DE Water distribution systems; Contamination; Simulation; Terrorism;
Accidents; Potable water; Municipal water; Water quality; Public health
ID DRINKING-WATER; WARNING SYSTEMS; MODEL; EXPOSURE; DESIGN
AB Properly designing contamination warning systems requires an understanding of potential public health impacts for a range of contaminated water systems and a wide range of contaminants. To address this need, we determined potential impacts for 12 actual systems serving populations ranging from similar to 10(4) to over 10(6) persons by simulating contamination events for the systems. We found several consistent patterns in the estimated impacts (defined as the size of the population receiving an ingestion dose above a given level). Significant impacts, those similar to worst-case impacts, result from injections of contaminants at only a minority of nodes. For contaminants with high thresholds for adverse effects, significant exposures are concentrated near the injection location, and impacts are not sensitive to population served. However, for contaminants with low thresholds, significant exposures are present over a significant fraction of the system, and impacts are sensitive to population. When exposures are concentrated near the injection node, the area affected tends to decrease with increasing population density. Accounting for all possible exposures and events may complicate the design of contamination warning systems.
C1 [Davis, Michael J.] Argonne Natl Lab, Div Environm Sci, Argonne, IL 60439 USA.
[Janke, Robert] US EPA, Natl Homeland Secur Res Ctr, Cincinnati, OH 45268 USA.
RP Davis, MJ (reprint author), Argonne Natl Lab, Div Environm Sci, 9700 S Cass Ave, Argonne, IL 60439 USA.
EM mike_davis@anl.gov; janke.robert@epamail.epa.gov
FU U.S. Environmental Protection Agency (USEPA), Office of Research and
Development; USEPA through U.S. Department of Energy [DE-AC02-06CH11357]
FX The U.S. Environmental Protection Agency (USEPA), Office of Research and
Development funded, managed, and participated in the research described
here under an interagency agreement. The views expressed in this paper
are those of the writers and do not necessarily reflect the views or
policies of the USEPA. Mention of trade names or commercial products
does not constitute endorsement or recommendation for use. Work at
Argonne National Laboratory was sponsored by the USEPA under an
interagency agreement through U.S. Department of Energy Contract No.
DE-AC02-06CH11357. All postsimulation data analysis and preparation of
graphics for this paper were done with R (R Development Core Team 2008).
Anonymous reviewers provided helpful comments.
NR 17
TC 12
Z9 12
U1 0
U2 8
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-9496
J9 J WATER RES PL-ASCE
JI J. Water Resour. Plan. Manage.-ASCE
PD JAN-FEB
PY 2011
VL 137
IS 1
BP 1
EP 9
DI 10.1061/(ASCE)WR.1943-5452.0000084
PG 9
WC Engineering, Civil; Water Resources
SC Engineering; Water Resources
GA 696XH
UT WOS:000285474200001
ER
PT J
AU Turek, NF
Kasten, L
Lytle, DA
Goltz, MN
AF Turek, Nadja F.
Kasten, Linda
Lytle, Darren A.
Goltz, Mark N.
TI Impact of plumbing age on copper levels in drinking water
SO JOURNAL OF WATER SUPPLY RESEARCH AND TECHNOLOGY-AQUA
LA English
DT Article
DE copper; drinking water; plumbing age
ID BY-PRODUCT RELEASE; NEUTRAL TAP WATER; DISTRIBUTION-SYSTEMS; CORROSION
BEHAVIOR; ORGANIC-MATTER; LEAD; TEMPERATURE; INHIBITION; METALS; PH
AB Theory and practical experiences suggest that higher copper levels in drinking water tap samples are typically associated with newer plumbing systems, and levels decrease with increasing plumbing age. Past researchers have developed a conceptual model to explain the 'aging effect' founded in the proposed evolution of copper(II) corrosion by-products on the pipe surface, based on theoretical considerations, anecdotal evidence and some data. In this study, the impact of plumbing age on copper levels in tap water samples and the internal surface corrosion of copper plumbing were systematically evaluated in 16 buildings with plumbing ages ranging from less than one to 44 years, using solids analysis approaches including XPS and XRD. Copper levels decreased with plumbing age and supported theory. A mix of stable and relatively unstable scales appeared on pipes, including cupric hydroxide, cuprite and malachite, although no obvious trend in scale composition with age was noted.
C1 [Lytle, Darren A.] US EPA, Cincinnati, OH 45268 USA.
[Turek, Nadja F.] Woolpert, Dayton, OH 45430 USA.
[Kasten, Linda] Univ Dayton, Res Inst, Dayton, OH 45469 USA.
[Goltz, Mark N.] USAF, Inst Technol, Wright Patterson AFB, OH 45433 USA.
RP Lytle, DA (reprint author), US EPA, Cincinnati, OH 45268 USA.
EM lytle.darren@epa.gov
OI Goltz, Mark/0000-0003-3601-6453
NR 48
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U1 3
U2 21
PU IWA PUBLISHING
PI LONDON
PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND
SN 0003-7214
J9 J WATER SUPPLY RES T
JI J. Water Supply Res Technol.-Aqua
PY 2011
VL 60
IS 1
BP 1
EP 15
DI 10.2166/aqua.2011.014
PG 15
WC Engineering, Civil; Water Resources
SC Engineering; Water Resources
GA 711LA
UT WOS:000286591900001
ER
PT B
AU Murray, S
Hertko, MD
AF Murray, Sylvester
Hertko, Mark D.
BE Johnson, NJ
Svara, JH
TI Environmental Justice and Land Use Planning
SO JUSTICE FOR ALL: PROMOTING SOCIAL EQUITY IN PUBLIC ADMINISTRATION
SE Transformational Trends in Governance and Democracy
LA English
DT Article; Book Chapter
C1 [Murray, Sylvester] Savannah State Univ, Govt & Publ Adm, Savannah, GA 31404 USA.
[Murray, Sylvester] SSU, Master Publ Adm Program, Savannah, GA USA.
[Murray, Sylvester] Cleveland State Univ, Publ Management Program, Cleveland, OH 44115 USA.
[Murray, Sylvester] Cleveland State Univ, Levin Coll Urban Affairs, Cleveland, OH 44115 USA.
[Murray, Sylvester] Int City & Cty Management Assoc, Washington, DC USA.
[Murray, Sylvester] Amer Soc Publ Adm, Washington, DC USA.
[Murray, Sylvester] Natl Acad Publ Adm, Africa Working Grp, Washington, DC USA.
[Hertko, Mark D.] Natl Acad Publ Adm, Washington, DC USA.
[Hertko, Mark D.] NOAA, Dept Commerce, Silver Spring, MD USA.
[Hertko, Mark D.] Natl Pk Serv, Dept Interior, Washington, DC 20240 USA.
[Hertko, Mark D.] US EPA, Washington, DC 20460 USA.
[Hertko, Mark D.] US DOE, Off Energy Efficiency & Renewable Energy, Washington, DC 20585 USA.
RP Murray, S (reprint author), Savannah State Univ, Govt & Publ Adm, Savannah, GA 31404 USA.
NR 11
TC 2
Z9 2
U1 0
U2 0
PU ROUTLEDGE
PI ABINGDON
PA 2 PARK SQ, MILTON PARK, ABINGDON OX14 4RN, OXFORD, ENGLAND
BN 978-0-7656-3026-1; 978-1-317-46673-4; 978-0-7656-3025-4
J9 TRANSFORM TR GOV DEM
PY 2011
BP 192
EP 206
PG 15
WC Public Administration
SC Public Administration
GA BF6MW
UT WOS:000383343200011
ER
PT J
AU O'Connell, HA
Rose, LJ
Shams, AM
Arduino, MJ
Rice, EW
AF O'Connell, H. A.
Rose, L. J.
Shams, A. M.
Arduino, M. J.
Rice, E. W.
TI Chlorine disinfection of Francisella tularensis
SO LETTERS IN APPLIED MICROBIOLOGY
LA English
DT Article
DE chlorine; disinfection; drinking water; Francisella tularensis; select
agents; tularemia; waterborne illness
ID STRAIN; TULAREMIA; SURVIVAL; AGENTS
AB Aims:
To determine the range of free available chlorine (FAC) required for disinfection of the live vaccine strain (LVS) and wild-type strains of Francisella tularensis.
Methods and Results:
Seven strains of planktonic F. tularensis were exposed to 0 center dot 5 mg center dot l-1 FAC for two pH values, 7 and 8, at 5 and 25 degrees C. LVS was inactivated 2 to 4 times more quickly than any of the wild-type F. tularensis strains at pH 8 and 5 degrees C.
Conclusions:
Free available chlorine residual concentrations routinely maintained in drinking water distribution systems would require up to two hours to reduce all F. tularensis strains by 4 log(10). LVS was inactivated most quickly of the tested strains.
Significance and Impact of the Study:
This work provides contact time (CT) values that are useful for drinking water risk assessment and also suggests that LVS may not be a good surrogate in disinfection studies.
C1 [O'Connell, H. A.; Rose, L. J.; Shams, A. M.; Arduino, M. J.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Rice, E. W.] US EPA, Cincinnati, OH 45268 USA.
RP O'Connell, HA (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,MS C-16, Atlanta, GA 30333 USA.
EM ftw2@cdc.gov
RI Arduino, Matthew/C-1461-2012
OI Arduino, Matthew/0000-0001-7072-538X
FU EPA [92288001-1]; CDC [92288001-1]
FX This research is made possible by an intra-agency agreement between the
EPA and CDC, # 92288001-1. The findings and conclusions in this report
are those of the author(s) and do not necessarily represent the views of
the Centers for Disease Control and Prevention or the United States
Environmental Protection Agency.
NR 18
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U1 2
U2 3
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0266-8254
J9 LETT APPL MICROBIOL
JI Lett. Appl. Microbiol.
PD JAN
PY 2011
VL 52
IS 1
BP 84
EP 86
DI 10.1111/j.1472-765X.2010.02971.x
PG 3
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA 693DX
UT WOS:000285205900013
PM 21189486
ER
PT J
AU Devereux, R
Yates, DF
Aukamp, J
Quarles, RL
Jordan, SJ
Stanley, RS
Eldridge, PM
AF Devereux, Richard
Yates, Diane F.
Aukamp, Jessica
Quarles, Robert L.
Jordan, Stephen J.
Stanley, Roman S.
Eldridge, Peter M.
TI Interactions of Thalassia testudinum and sediment biogeochemsistry in
Santa Rosa Sound, NW Florida
SO MARINE BIOLOGY RESEARCH
LA English
DT Article
DE Biogeochemistry; seagrass; sediments; sulfate reduction
ID SULFATE REDUCTION RATES; BANKS EX KONIG; ZOSTERA-MARINA; CARBONATE
SEDIMENTS; SEAGRASS GROWTH; ORGANIC-MATTER; P RATIOS; SULFIDE; LIGHT;
IRON
AB Thalassia testudinum belowground biomass weights, leaf weights, leaf growth rates, areal shoot densities (m-2), and leaf C:N:P ratios were compared to a set of biogeochemical parameters to gain information on seagrass-sediment interactions that may influence seagrass growth. Data were compiled from three surveys conducted in Santa Rosa Sound, located in northwest Florida, at three different meadows in sequential years. Biomass measurements and leaf growth rates decreased between stations along transects from shallow to deeper water. Belowground biomass weights decreased and leaf C:P ratios increased with temperature reflecting a seasonal growth pattern. The T. testudinum parameters were highly correlated with each other. Sulfate reduction rates (at times exceeding 1000 nmol ml-1 day-1) were among the highest recorded for seagrass beds with temperature accounting for 79% of the variation. Even though sulfate reduction rates were high, total Fe:reduced S ratios indicated sufficient Fe to account for all reduced S as pyrite. Sediment Fe, C, N, and organic P concentrations increased with sediment depth, whereas inorganic P decreased with depth, suggesting burial of organic P and root uptake of inorganic P. Leaf C:N:P ratios indicated P-limited growth for two surveys. NH4 + was detected in water above the sediment surface during some surveys demonstrating T. testudinum meadows at times may serve as sources of inorganic N to the water column. Plant parameters correlated with concentrations of sediment organic C and N, Fe, S, and porewater NH4 +. These results highlight the importance of the organic matter and Fe contents of sediments to seagrass growth.
C1 [Devereux, Richard] US EPA, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, Gulf Breeze, FL 32561 USA.
[Eldridge, Peter M.] US EPA, Natl Hlth & Environm Effects Res Lab, New Port, OR USA.
RP Devereux, R (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA.
EM devereux.richard@epa.gov
FU US Environmental Protection Agency
FX We thank the GED field and dive teams for their assistance with sample
collections; Jed Campbell, Will Davis, Peggy Harris, Becky Hemmer,
Deborah Santavy, and Sherry Vickery; Brad Blackwell, and George Smith
for additional technical support; and Paul Soderlind for preparation of
figures. The information in this document has been funded wholly or in
part by the US Environmental Protection Agency. It has been subjected to
review by the National Health and Environmental Effects Research
Laboratory and approved for publication. Approval does not signify that
the contents reflect the views of the Agency, nor does mention of trade
names or commercial products constitute endorsement or recommendation
for use. This is contribution no. 1344 from USEPA NHEERL Gulf Ecology
Division.
NR 48
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U1 3
U2 17
PU TAYLOR & FRANCIS AS
PI OSLO
PA KARL JOHANS GATE 5, NO-0154 OSLO, NORWAY
SN 1745-1000
J9 MAR BIOL RES
JI Mar. Biol. Res.
PY 2011
VL 7
IS 4
BP 317
EP 331
AR PII 936414871
DI 10.1080/17451000.2010.515227
PG 15
WC Ecology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA 751KR
UT WOS:000289616900001
ER
PT J
AU MacArthur, LD
Phillips, DL
Hyndes, GA
Hanson, CE
Vanderklift, MA
AF MacArthur, Lachlan D.
Phillips, Donald L.
Hyndes, Glenn A.
Hanson, Christine E.
Vanderklift, Mathew A.
TI Habitat surrounding patch reefs influences the diet and nutrition of the
western rock lobster
SO MARINE ECOLOGY PROGRESS SERIES
LA English
DT Article
DE Stable isotope; Feeding; Landscape ecology; Seagrass; Mixing model;
Panulirus cygnus
ID PANULIRUS-CYGNUS GEORGE; ISOTOPE MIXING MODELS; PREDATOR PREY
INTERACTIONS; SPINY LOBSTER; AMPHIBOLIS-GRIFFITHII; STABLE-ISOTOPES;
SEAGRASS BED; POSIDONIA-AUSTRALIS; JASUS-EDWARDSII; CARBON ISOTOPES
AB This study investigated the influence of the spatial arrangement of habitat patches on the diet and nutrition of a common reef-associated generalist consumer, the western rock lobster Panulirus cygnus. Stable isotopes (C-13/C-12 and N-15/N-14) and gut contents were used to assess diet and nutrition of lobsters collected from 8 shallow patch-reef sites on the lower west coast of Australia in April and October 2005. A distance-based linear model indicated that the predominant benthic habitat surrounding a reef (seagrass or macroalgae/sand-dominated) was an important source of variation in diet and nutrition, explaining significant (p < 0.01) variation in isotope signatures and gut contents of 52.7 and 7.0%, respectively. Mobile invertebrates, sessile filter feeders, coralline algae and seagrass were consumed by lobsters from all sites, but sessile filter feeders (sponges and colonial ascidians) were consumed in significantly greater volumes (p < 0.05) at macroalgae/sand-dominated sites (21.16 +/- 3.0%) than at seagrass-dominated sites (<= 6.1 +/- 1.08%). A modified mass balance mixing model (IsoSource), which factored in C:N ratios of food sources and lobster-specific delta C-13 and delta N-15 discrimination values, was used to determine the contribution of food sources to lobster nutrition. Articulated coralline red algae were an important source, especially from sites dominated by macroalgae and sand contributing 22-72% to nutrition. Bait potentially contributes up to similar to 30% of lobster muscle nutrition and therefore may also play an important nutritional role for lobsters in areas where lobster potting occurs. Macroalgae, rather than seagrass, appears the most likely autochthonous energy source driving P. cygnus production in shallow coastal waters; however, seagrass plays an important role as habitat for lobster prey.
C1 [MacArthur, Lachlan D.; Hyndes, Glenn A.; Hanson, Christine E.] Edith Cowan Univ, Sch Nat Sci, Ctr Marine Ecosyst Res, Joondalup, WA 6027, Australia.
[Phillips, Donald L.] US EPA, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97333 USA.
[Vanderklift, Mathew A.] CSIRO Marine & Atmospher Res, Wembley, WA 6913, Australia.
RP MacArthur, LD (reprint author), Sinclair Knight Merz, Floor Durack Ctr 11, 263 Adelaide Tce, Perth, WA 6000, Australia.
EM lmacarthur@skm.com.au
RI Vanderklift, Mathew/B-1003-2008
FU Edith Cowan University; Strategic Research Fund for the Marine
Environment
FX This paper has been subjected to the US Environmental Protection
Agency's peer and administrative review and approved for publication.
Mention of trade names or commercial products does not constitute
endorsement or recommendation for use. The authors gratefully
acknowledge R. Babcock, K. & B. Cook, J. Eyres, E. Gates, S. Harrison,
R. Kenna, M. Nyegaard, A. Tennyson and K. Waddington for assistance in
the field and J. Tranter for the stable isotope analysis. The authors
acknowledge the contributions of 2 anonymous reviewers, which improved
the manuscript. Financial support for this study was provided by Edith
Cowan University and the Strategic Research Fund for the Marine
Environment.
NR 70
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U1 1
U2 27
PU INTER-RESEARCH
PI OLDENDORF LUHE
PA NORDBUNTE 23, D-21385 OLDENDORF LUHE, GERMANY
SN 0171-8630
J9 MAR ECOL PROG SER
JI Mar. Ecol.-Prog. Ser.
PY 2011
VL 436
BP 191
EP 205
DI 10.3354/meps09256
PG 15
WC Ecology; Marine & Freshwater Biology; Oceanography
SC Environmental Sciences & Ecology; Marine & Freshwater Biology;
Oceanography
GA 816RM
UT WOS:000294619800014
ER
PT J
AU Grear, JS
Horowitz, DB
Gutjahr-Gobell, R
AF Grear, Jason S.
Horowitz, Doranne Borsay
Gutjahr-Gobell, Ruth
TI Mysid population responses to resource limitation differ from those
predicted by cohort studies
SO MARINE ECOLOGY PROGRESS SERIES
LA English
DT Article
DE Inverse demography; Zooplankton; Population model; Cohort; Survival;
Americamysis bahia
ID OCEAN ACIDIFICATION; AMERICAMYSIS-BAHIA; TOXICITY; DYNAMICS
AB Effects of anthropogenic stressors on animal populations are often evaluated by assembling vital rate responses from isolated cohort studies into a single demographic model. However, these models are difficult to translate into ecological predictions because stressor effects observed in isolated cohorts may differ from those occurring in populations with overlapping generations. This problem is evident in many areas of stressor-response research, including the burgeoning work on ocean acidification. To address this problem, we compared vital rates in experimental cohorts and populations of the mysid Americamysis bahia at 4 levels of resource limitation. This required development of a novel observational scheme that allows inverse estimation of stage-specific vital rates in mixed-age populations without the use of cohort isolation or marking. Using digitally imaged time series observations of stage abundances, the most strongly supported inverse models indicated opposing (i.e. compensatory) effects of resource limitation on adult survival and juvenile maturation. The model with adult survival response only (i.e. no compensation) was also strongly supported. This contrasts with cohort results, where feeding effects on fecundity were strongest. These results suggest that emphasis in stressor-response studies on early life stages and cohorts of uniformly aged individuals may miss important demographic responses and should be augmented by observations of intact populations, especially as methods such as ours become more available.
C1 [Grear, Jason S.; Horowitz, Doranne Borsay; Gutjahr-Gobell, Ruth] US EPA, Atlantic Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Narragansett, RI 02882 USA.
RP Grear, JS (reprint author), US EPA, Atlantic Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Narragansett, RI 02882 USA.
EM grear.jason@epa.gov
FU EPA
FX We thank J. Nye, S. Raimondo and A. Oczkowski for comments on an early
version of the manuscript. K. McKeton, I. Kirby, E. Perkins, J. Pierce
and P. Hackett also assisted in this work. This is contribution number
AED-10-066 of the Atlantic Ecology Division, National Health and
Environmental Effects Research Laboratory, Office of Research and
Development, US Environmental Protection Agency (EPA). Although the
research described in this article was funded by the EPA, it has not
been subjected to agency review and does not necessarily reflect the
views of the agency.
NR 26
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U1 0
U2 10
PU INTER-RESEARCH
PI OLDENDORF LUHE
PA NORDBUNTE 23, D-21385 OLDENDORF LUHE, GERMANY
SN 0171-8630
J9 MAR ECOL PROG SER
JI Mar. Ecol.-Prog. Ser.
PY 2011
VL 432
BP 115
EP 123
DI 10.3354/meps09158
PG 9
WC Ecology; Marine & Freshwater Biology; Oceanography
SC Environmental Sciences & Ecology; Marine & Freshwater Biology;
Oceanography
GA 784NE
UT WOS:000292163200010
ER
PT J
AU Yee, SH
Santavy, DL
Kern, JW
Hession, S
AF Yee, Susan Harrell
Santavy, Deborah L.
Kern, John W.
Hession, Sarah
TI Consideration of species community composition in statistical analyses
of coral disease risk
SO MARINE ECOLOGY PROGRESS SERIES
LA English
DT Article
DE Coral; Disease; Bleaching; Community composition; Species distribution;
Regression models
ID BLACK-BAND DISEASE; GREAT-BARRIER-REEF; US VIRGIN-ISLANDS; FLORIDA-KEYS;
SCLERACTINIAN CORAL; SPATIAL VARIABILITY; ACROPORA-PALMATA;
CLIMATE-CHANGE; WEST-INDIES; PATTERNS
AB Diseases are increasing in marine ecosystems, and these increases have been attributed to a number of environmental factors including climate change, pollution, and overfishing. However, many studies pool disease prevalence into taxonomic groups, disregarding host-species composition when comparing sites or assessing environmental impacts on patterns of disease presence. We used simulated data under a known environmental effect to assess the ability of standard statistical methods (binomial and linear regression, ANOVA) to detect a significant environmental effect on pooled disease prevalence with varying species abundance distributions and relative susceptibilities to disease. When one species was more susceptible to a disease and both species only partially overlapped in their distributions, models tended to produce a greater number of false positives (Type I error). Differences in disease risk between regions or along an environmental gradient tended to be underestimated, or, even in the wrong direction, when highly susceptible taxa had reduced abundances in impacted sites, a situation likely to be common in nature. Including relative abundance as an additional variable in regressions improved model accuracy, but tended to be conservative, producing more false negatives (Type II error) when species abundance was strongly correlated with the environmental effect. An analysis of field data on bleaching from the Florida Keys, FL, USA, affirmed general results of model simulations. Investigators should be cautious of underlying assumptions about species similarity in susceptibility and species composition when interpreting pooled data on disease risk.
C1 [Yee, Susan Harrell; Santavy, Deborah L.] US EPA, Gulf Ecol Div, Natl Hlth & Environm Effects Res Lab, Gulf Breeze, FL 32561 USA.
[Kern, John W.; Hession, Sarah] Kern Stat Serv Inc, Sauk Rapids, MN 56379 USA.
RP Yee, SH (reprint author), US EPA, Gulf Ecol Div, Natl Hlth & Environm Effects Res Lab, Gulf Breeze, FL 32561 USA.
EM yee.susan@epa.gov
FU US Environmental Protection Agency (US EPA); NOAA
FX We thank 3 anonymous reviewers for helpful comments on prior versions.
Field data were collected under research permits to D. L. S, E. Mueller,
and L. MacLaughlin by Florida Keys National Marine Sanctuary, Dry
Tortugas National Park, and Biscayne National Park from 1998 to 2005.
Ship support was provided by the US Environmental Protection Agency (US
EPA) (OSV 'Anderson') and the NOAA (RV 'Nancy Foster'). Field support
was provided by: J. Campbell, L. MacLaughlin, E. Mueller, J. Patrick, M.
Parsons, R. Quarles, and others. This paper has been re viewed in
accordance with the US EPA's peer and administrative review policies and
approved for publication. Mention of trade names or commercial products
does not constitute endorsement or recommendation for use. This is
Contribution Number 1410 from the Gulf Ecology Division.
NR 69
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U1 2
U2 15
PU INTER-RESEARCH
PI OLDENDORF LUHE
PA NORDBUNTE 23, D-21385 OLDENDORF LUHE, GERMANY
SN 0171-8630
J9 MAR ECOL PROG SER
JI Mar. Ecol.-Prog. Ser.
PY 2011
VL 431
BP 83
EP 96
DI 10.3354/meps09135
PG 14
WC Ecology; Marine & Freshwater Biology; Oceanography
SC Environmental Sciences & Ecology; Marine & Freshwater Biology;
Oceanography
GA 781SF
UT WOS:000291953100007
ER
PT S
AU Ralston-Hooper, K
Jannasch, A
Adamec, J
Sepulveda, M
AF Ralston-Hooper, Kimberly
Jannasch, Amber
Adamec, Jiri
Sepulveda, Maria
BE Metz, TO
TI The Use of Two-Dimensional Gas Chromatography-Time-of-Flight Mass
Spectrometry (GC x GC-TOF-MS) for Metabolomic Analysis of Polar
Metabolites
SO METABOLIC PROFILING: METHODS AND PROTOCOLS
SE Methods in Molecular Biology
LA English
DT Article; Book Chapter
DE Two-dimensional gas chromatography; time of flight; mass spectrometry
ID METHODOLOGIES; SPECTROSCOPY; ALGORITHM; DISCOVERY; LIVER; FISH
AB Metabolites produced by an organism can be quite extensive, and one analytical technique alone is not capable of their comprehensive detection and identification. The majority of environmental metabolomic studies have implemented proton nuclear magnetic resonance (H-1-NMR) spectroscopy with little attention given to mass spectrometry (MS) techniques. In this chapter, an analytical technique is outlined that incorporates two-dimensional gas chromatography time-of-flight MS (GC x GC-TOF-MS) for the identification and quantification of polar metabolites.
C1 [Ralston-Hooper, Kimberly] CNR, Ecosyst Res Div, Athens, GA USA.
[Ralston-Hooper, Kimberly] US EPA, Athens, GA USA.
[Jannasch, Amber] Purdue Univ, Bindley Biosci Ctr, W Lafayette, IN 47907 USA.
[Adamec, Jiri] Univ Nebraska, Dept Biochem, Lincoln, NE 68583 USA.
[Sepulveda, Maria] Purdue Univ, Dept Nat Resources, W Lafayette, IN 47907 USA.
RP Ralston-Hooper, K (reprint author), CNR, Ecosyst Res Div, Athens, GA USA.
NR 20
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U1 1
U2 9
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA
SN 1064-3745
BN 978-1-61737-984-0
J9 METHODS MOL BIOL
JI Methods Mol. Biol.
PY 2011
VL 708
BP 205
EP 211
DI 10.1007/978-1-61737-985-7_12
D2 10.1007/978-1-61737-985-7
PG 7
WC Biochemical Research Methods; Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA BTC97
UT WOS:000286532100013
PM 21207292
ER
PT J
AU Ginsberg, G
Angle, K
Guyton, K
Sonawane, B
AF Ginsberg, Gary
Angle, Kenneth
Guyton, Kathryn
Sonawane, Babasaheb
TI Polymorphism in the DNA repair enzyme XRCC1: Utility of current database
and implications for human health risk assessment
SO MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
LA English
DT Review
DE Genetic polymorphism; XRCC1; DNA repair; Toxicodynamic modeling; Risk
assessment
ID BASE-EXCISION-REPAIR; BREAST-CANCER RISK; SQUAMOUS-CELL CARCINOMA;
SINGLE-NUCLEOTIDE POLYMORPHISMS; SISTER-CHROMATID EXCHANGE; LUNG-CANCER;
GENETIC POLYMORPHISMS; BLADDER-CANCER; MUTAGEN SENSITIVITY; CHINESE
POPULATION
AB Genetic polymorphisms are increasingly recognized as sources of variability not only in toxicokinetic but also in toxicodynamic response to environmental agents. XRCC1 is involved in base excision repair (BER) of DNA; it has variant genotypes that are associated with modified repair function. This analysis focuses on four polymorphisms: three in the coding region that affect protein structure and one in an upstream regulatory sequence that affects gene expression. The Arg399Gln variant is the most widely studied with evidence supporting a quantitative effect of genotype on phenotype. The homozygous variant (Gln/Gln) can have 3-4-fold diminished capacity to remove DNA adducts and oxidized DNA damage. This variant is relatively common in Caucasians and Asians where approximately 10% are homozygous variant. In contrast, the Arg194Trp variant appears to protect against genotoxic effects although the degree to which DNA repair is enhanced by this polymorphism is uncertain. The homozygous variant is rare in Caucasians and African Americans but it is present at 7% in Asians. A third coding region polymorphism at codon 280 appears to decrease repair function but additional quantitative information is needed and the homozygous variant is rare across populations studied. A polymorphism in an upstream promoter binding sequence (-77T > C) appears to lower XRCC1 levels by decreasing gene expression. Based upon genotype effect on phenotype and allele frequency, the current analysis finds that the codon 399 and upstream (-77) polymorphisms have the greatest potential to affect the toxicodynamic response to DNA damaging agents. However, the implications for risk assessment are limited by the likelihood that polymorphisms in multiple BER genes interact to modulate DNA repair. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Ginsberg, Gary] Connecticut Dept Publ Hlth, Hartford, CT USA.
[Angle, Kenneth] Univ Connecticut, Sch Publ Hlth, Farmington, CT USA.
[Guyton, Kathryn; Sonawane, Babasaheb] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
RP Ginsberg, G (reprint author), Connecticut Dept Publ Hlth, Hartford, CT USA.
EM gary.ginsberg@ct.gov
NR 105
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Z9 46
U1 0
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1383-5742
J9 MUTAT RES-REV MUTAT
JI Mutat. Res.-Rev. Mutat. Res.
PD JAN-APR
PY 2011
VL 727
IS 1-2
BP 1
EP 15
DI 10.1016/j.mrrev.2011.02.001
PG 15
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
GA 772NJ
UT WOS:000291240300001
PM 21352951
ER
PT J
AU Gwinn, MR
Johns, DO
Bateson, TF
Guyton, KZ
AF Gwinn, Maureen R.
Johns, Douglas O.
Bateson, Thomas F.
Guyton, Kathryn Z.
TI A review of the genotoxicity of 1,2-dichloroethane (EDC)
SO MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
LA English
DT Review
DE 1,2-Dichloroethane; Genotoxicity; Mutagenicity
ID GLUTATHIONE-S-TRANSFERASE; HALOGENATED ALIPHATIC-HYDROCARBONS; TEXAS
CHEMICAL-PLANT; DNA COVALENT BINDING; SALMONELLA-TYPHIMURIUM;
DROSOPHILA-MELANOGASTER; ETHYLENE DICHLORIDE; CHLORINATED HYDROCARBONS;
PETROCHEMICAL WORKERS; INVIVO GENOTOXICITY
AB 1,2-Dichloroethane (EDC, CAS#107-06-2) is a high production volume halogenated aliphatic hydrocarbon that is used mainly in the manufacture of vinyl chloride. EDC has been found in ambient and residential air samples, as well as in groundwater, surface water and drinking water. EDC has been well-studied in a variety of genotoxicity assays, and appears to involve the metabolic activation of the parent compound. We critically evaluated the genotoxicity data of EDC and its metabolites as part of an evaluation of carcinogenic mechanisms of action of EDC. EDC is genotoxic in multiple test systems via multiple routes of exposure. EDC has been shown to induce DNA adduct formation, gene mutations and chromosomal aberrations in the presence of key activation enzymes (including CYP4505 and/or GSTs) in laboratory animal and in vitro studies. EDC was negative for clastogenesis as measured by the micronucleus assay in mice. In general, an increased level of DNA damage is observed related to the GSH-dependent bioactivation of EDC. Increased chromosomal aberrations with increased CYP450 expression were suggestive of a role for the oxidative metabolites of EDC in inducing chromosomal damage. Taken together, these studies demonstrate that EDC exposure, in the presence of key enzymes (including CYP4505 and/or GSTs), leads to DNA adduct formation, gene mutations and chromosomal aberrations. Published by Elsevier B.V.
C1 [Gwinn, Maureen R.; Bateson, Thomas F.; Guyton, Kathryn Z.] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
[Johns, Douglas O.] US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA.
RP Gwinn, MR (reprint author), 1200 Penn Ave NW,MC-8623-P, Washington, DC 20460 USA.
EM gwinn.maureen@epa.gov
NR 120
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Z9 9
U1 3
U2 34
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1383-5742
J9 MUTAT RES-REV MUTAT
JI Mutat. Res.-Rev. Mutat. Res.
PD JAN-APR
PY 2011
VL 727
IS 1-2
BP 42
EP 53
DI 10.1016/j.mrrev.2011.01.001
PG 12
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
GA 772NJ
UT WOS:000291240300003
PM 21255676
ER
PT J
AU Kou, JH
Bennett-Stamper, C
Varma, RS
AF Kou, Jiahui
Bennett-Stamper, Christina
Varma, Rajender S.
TI Hierarchically triangular prism structured Co3O4: self-supported
fabrication and photocatalytic property
SO NANOSCALE
LA English
DT Article
ID HYDROTALCITE-LIKE COMPOUNDS; ION BATTERY ELECTRODES; COBALT OXIDE; GAS
SENSORS; HYDROXIDE; NANOSTRUCTURES; PRECURSOR; ROUTE; SHAPE;
NANOCRYSTALS
AB The formation of ammonium cobalt(II) phosphate was utilized to synthesize unprecedented 3D structures of Co3O4, triangular prisms, via a self-supported and organics-free method. The structure is shaped by stacking hundreds of small nanoplatelets; diameters and thicknesses of platelets are similar to 100 nm and similar to 20 nm, respectively.
C1 [Kou, Jiahui; Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
[Bennett-Stamper, Christina] US EPA, Water Supply Water Resources Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Varma, RS (reprint author), US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, 26 W Martin Luther King Dr,MS 443, Cincinnati, OH 45268 USA.
EM Varma.Rajender@epa.gov
NR 29
TC 14
Z9 16
U1 6
U2 55
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2040-3364
J9 NANOSCALE
JI Nanoscale
PY 2011
VL 3
IS 12
BP 4958
EP 4961
DI 10.1039/c1nr10826c
PG 4
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
Science, Multidisciplinary; Physics, Applied
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA 855ST
UT WOS:000297585500010
ER
PT J
AU Carey, AM
Norton, GJ
Deacon, C
Scheckel, KG
Lombi, E
Punshon, T
Guerinot, ML
Lanzirotti, A
Newville, M
Choi, YS
Price, AH
Meharg, AA
AF Carey, Anne-Marie
Norton, Gareth J.
Deacon, Claire
Scheckel, Kirk G.
Lombi, Enzo
Punshon, Tracy
Guerinot, Mary Lou
Lanzirotti, Antonio
Newville, Matt
Choi, Yongseong
Price, Adam H.
Meharg, Andrew A.
TI Phloem transport of arsenic species from flag leaf to grain during grain
filling
SO NEW PHYTOLOGIST
LA English
DT Article
DE arsenic; grain filling; phloem; rice; translocation
ID RICE CULTIVARS; PADDY RICE; ACCUMULATION; SPECIATION; PLANTS; WHEAT;
TRANSLOCATION; LOCALIZATION; SILICON; BARLEY
AB Strategies to reduce arsenic (As) in rice grain, below concentrations that represent a serious human health concern, require that the mechanisms of As accumulation within grain be established. Therefore, retranslocation of As species from flag leaves into filling rice grain was investigated.
Arsenic species were delivered through cut flag leaves during grain fill. Spatial unloading within grains was investigated using synchrotron X-ray fluorescence (SXRF) microtomography. Additionally, the effect of germanic acid (a silicic acid analog) on grain As accumulation in arsenite-treated panicles was examined.
Dimethylarsinic acid (DMA) and monomethylarsonic acid (MMA) were extremely efficiently retranslocated from flag leaves to rice grain; arsenate was poorly retranslocated, and was rapidly reduced to arsenite within flag leaves; arsenite displayed no retranslocation. Within grains, DMA rapidly dispersed while MMA and inorganic As remained close to the entry point. Germanic acid addition did not affect grain As in arsenite-treated panicles. Three-dimensional SXRF microtomography gave further information on arsenite localization in the ovular vascular trace (OVT) of rice grains.
These results demonstrate that inorganic As is poorly remobilized, while organic species are readily remobilized, from leaves to grain. Stem translocation of inorganic As may not rely solely on silicic acid transporters.
C1 [Carey, Anne-Marie; Norton, Gareth J.; Deacon, Claire; Price, Adam H.; Meharg, Andrew A.] Univ Aberdeen, Inst Biol & Environm Sci, Aberdeen AB24 3UU, Scotland.
[Scheckel, Kirk G.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45224 USA.
[Lombi, Enzo] Univ S Australia, Ctr Environm Risk Assessment & Remediat, Mawson Lakes, SA 5095, Australia.
[Punshon, Tracy; Guerinot, Mary Lou] Dartmouth Coll, Dept Biol Sci, Hanover, NH 03755 USA.
[Lanzirotti, Antonio; Newville, Matt; Choi, Yongseong] Univ Chicago, Ctr Adv Radiat Sources, Chicago, IL 60637 USA.
RP Meharg, AA (reprint author), Univ Aberdeen, Inst Biol & Environm Sci, Cruickshank Bldg,St Machar Dr, Aberdeen AB24 3UU, Scotland.
EM a.meharg@abdn.ac.uk
RI Norton, Gareth/D-7512-2012; Scheckel, Kirk/C-3082-2009; Lombi,
Enzo/F-3860-2013; Meharg, Andrew/F-8182-2014;
OI Scheckel, Kirk/0000-0001-9326-9241; Lombi, Enzo/0000-0003-3384-0375;
Meharg, Andrew/0000-0003-2019-0449; Carey,
Anne-Marie/0000-0001-6409-6580; Norton, Gareth/0000-0003-4560-170X
FU Biotechnology and Biological Sciences Research Council; National
Institute of Environmental Health Sciences [P42 ES007373-14]; National
Science Foundation - Earth Sciences [EAR-0622171]; Department of Energy
- Geosciences [DE-FG02-94ER14466, DE-FG02-92ER14244]; US Department of
Energy, Office of Science, Office of Basic Energy Science
[DE-AC02-06CH11357]; DOE - Office of Biological and Environmental
Research, Environmental Remediation Sciences Div. [DE-FC09-96-SR18546];
DOE [DE-AC02-98CH10886]; US Environmental Protection Agency, through its
Office of Research and Development
FX This work was supported by a Biotechnology and Biological Sciences
Research Council Doctoral Training Grant and by grants from the National
Institute of Environmental Health Sciences, Superfund Research Program
(grant no. P42 ES007373-14) to T. P. and M. L. G. Its contents are
solely the responsibility of the authors and do not necessarily
represent the official views of NIH. Portions of this work were
performed at GeoSoilEnviroCARS (Sector 13), Advanced Photon Source
(APS), Argonne National Laboratory. GeoSoilEnviroCARS is supported by
the National Science Foundation - Earth Sciences (EAR-0622171) and
Department of Energy - Geosciences (DE-FG02-94ER14466). Use of the
Advanced Photon Source was supported by the US Department of Energy,
Office of Science, Office of Basic Energy Sciences, under contract no.
DE-AC02-06CH11357. A portion of this work was performed at Beamline
X26A, National Synchrotron Light Source (NSLS), Brookhaven National
Laboratory. X26A is supported by the Department of Energy (DOE) -
Geosciences (DE-FG02-92ER14244 to The University of Chicago - CARS) and
DOE - Office of Biological and Environmental Research, Environmental
Remediation Sciences Div. (DE-FC09-96-SR18546 to the University of
Kentucky). Use of the NSLS was supported by DOE under contract no.
DE-AC02-98CH10886. The US Environmental Protection Agency, through its
Office of Research and Development, funded and managed a portion of the
research; it has not been subject to Agency review and, therefore, does
not necessarily reflect the views of the Agency, no official product
endorsement should be inferred. We would like to express our sincere
gratitude to Norman Little and Dave Hadwen of the University of Aberdeen
and to all the staff of Sector 13 at the APS for their support.
NR 44
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PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0028-646X
J9 NEW PHYTOL
JI New Phytol.
PY 2011
VL 192
IS 1
BP 87
EP 98
DI 10.1111/j.1469-8137.2011.03789.x
PG 12
WC Plant Sciences
SC Plant Sciences
GA 815VZ
UT WOS:000294559400009
PM 21658183
ER
PT J
AU Londo, JP
Bollman, MA
Sagers, CL
Lee, EH
Watrud, LS
AF Londo, Jason P.
Bollman, Michael A.
Sagers, Cynthia L.
Lee, E. Henry
Watrud, Lidia S.
TI Glyphosate-drift but not herbivory alters the rate of transgene flow
from single and stacked trait transgenic canola (Brassica napus) to
nontransgenic B. napus and B. rapa
SO NEW PHYTOLOGIST
LA English
DT Article
DE Brassica; canola; CP4 EPSPS; Cry1Ac; glyphosate resistance; lepidopteran
resistance; transgene flow
ID HERBICIDE-RESISTANT CANOLA; GENE FLOW; OILSEED RAPE; POLLEN VIABILITY;
WILD RELATIVES; MALE-STERILITY; HYBRIDIZATION; FITNESS; FIELDS; CROPS
AB Transgenic plants can offer agricultural benefits, but the escape of transgenes is an environmental concern. In this study we tested the hypothesis that glyphosate drift and herbivory selective pressures can change the rate of transgene flow between the crop Brassica napus (canola), and weedy species and contribute to the potential for increased transgene escape risk and persistence outside of cultivation.
We constructed plant communities containing single transgenic B. napus genotypes expressing glyphosate herbicide resistance (CP4 EPSPS), lepidopteran insect resistance (Cry1Ac), or both traits ('stacked'), plus nontransgenic B. napus, Brassica rapa and Brassica nigra. Two different selective pressures, a sublethal glyphosate dose and lepidopteran herbivores (Plutella xylostella), were applied and rates of transgene flow and transgenic seed production were measured.
Selective treatments differed in the degree in which they affected gene flow and production of transgenic hybrid seed. Most notably, glyphosate-drift increased the incidence of transgenic seeds on nontransgenic B. napus by altering flowering phenology and reproductive function.
The findings of this study indicate that transgenic traits may be transmitted to wild populations and may increase in frequency in weedy populations through the direct and indirect effects of selection pressures on gene flow.
C1 [Londo, Jason P.] CNR, Corvallis, OR 97333 USA.
[Bollman, Michael A.; Lee, E. Henry; Watrud, Lidia S.] US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA.
[Londo, Jason P.; Sagers, Cynthia L.] Univ Arkansas, Dept Biol Sci, Fayetteville, AR 72701 USA.
RP Londo, JP (reprint author), CNR, 200 SW 35th St, Corvallis, OR 97333 USA.
EM jlondo@uark.edu
FU US Environmental Protection Agency; USDA CREES NRI [35615-19216]
FX We acknowledge horticultural and technical support provided by George
King, Milt Plocher, Marjorie Storm, Gail Heine and Fred Senecal (Dynamac
Corporation). We thank Dr Neal Stewart Jr for providing the original B.
napus insect-resistant B. napus cv TnWestar genotype. The information in
this document has been funded in part by the US Environmental Protection
Agency. It has been subjected to review by the National Health and
Environmental Effects Research Laboratory's Western Ecology Division and
approved for publication. Approval does not signify that the contents
reflect the views of the Agency; neither does mention of trade names or
commercial products constitute endorsement or recommendation for use. A
portion of this work was completed with funding from USDA CREES NRI
35615-19216 for CLS.
NR 50
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U1 4
U2 22
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0028-646X
J9 NEW PHYTOL
JI New Phytol.
PY 2011
VL 191
IS 3
BP 840
EP 849
DI 10.1111/j.1469-8137.2011.03706.x
PG 10
WC Plant Sciences
SC Plant Sciences
GA 794TQ
UT WOS:000292924600022
PM 21443650
ER
PT J
AU Brooks, JR
Mitchell, AK
AF Brooks, J. Renee
Mitchell, Alan K.
TI Interpreting tree responses to thinning and fertilization using
tree-ring stable isotopes
SO NEW PHYTOLOGIST
LA English
DT Article
DE canopy microclimate; carbon isotopes; fertilization; growth dynamics;
leaf nitrogen; oxygen isotopes; Pseudotsuga menziesii (Douglas-fir);
thinning
ID WATER-USE EFFICIENCY; FOLIAR NITROGEN CONCENTRATION; SOUTHERN
UNITED-STATES; MENZIESII VAR. GLAUCA; DOUGLAS-FIR; PINUS-PONDEROSA;
GROWTH-RESPONSE; CARBON ISOTOPES; OXYGEN; DISCRIMINATION
AB P>Carbon sequestration has focused renewed interest in understanding how forest management affects forest carbon gain over timescales of decades, and yet details of the physiological mechanisms over decades are often lacking for understanding long-term growth responses to management.
Here, we examined tree-ring growth patterns and stable isotopes of cellulose (delta 13C(cell) and delta 18O(cell)) in a thinning and fertilization controlled experiment where growth increased substantially in response to treatments to elucidate physiological data and to test the dual isotope approach for uses in other locations.
delta 13C(cell) and delta 18O(cell) results indicated that fertilization caused an increase in intrinsic water-use efficiency through increases in photosynthesis (A) for the first 3 yr. The combination treatment caused a much larger increase in A and water-use efficiency. Only the thinning treatments showed consistent significant increases in delta 18O(cell) above controls. Changes in canopy microclimate are the likely drivers for delta 18O(cell) increases with decreases in relative humidity and increases in leaf temperature associated with thinning being the most probable causes.
Tree-ring isotopic records, particularly delta 13C(cell), remain a viable way to reconstruct long-term physiological mechanisms affecting tree carbon gain in response to management and climate fluctuations.
C1 [Brooks, J. Renee] US EPA, NHEERL, Western Ecol Div, Corvallis, OR 97333 USA.
[Mitchell, Alan K.] Nat Resources Canada, Canadian Forest Serv, Canadian Wood Fibre Ctr, Victoria, BC, Canada.
RP Brooks, JR (reprint author), US EPA, NHEERL, Western Ecol Div, Corvallis, OR 97333 USA.
EM brooks.reneej@epa.gov
OI Brooks, Renee/0000-0002-5008-9774
FU US Environmental Protection Agency
FX We dedicate this manuscript to the memory of Holger Brix whose foresight
and research into physiological mechanisms behind tree responses to
thinning and fertilization made this study possible. This work was
supported by the US Environmental Protection Agency. This manuscript has
been subjected to the Environmental Protection Agency's peer and
administrative review, and it has been approved for publication as an
EPA document. Mention of trade names or commercial products does not
constitute endorsement or recommendation for use. This research was
conducted at the Shawnigan Lake Research Site established and maintained
by Canadian Forestry Service since 1971. Special thanks go to Tom Bown
and Graeme Goodmanson for their assistance tracking and sending samples,
and accessing historical data at this site. We thank Ross Benton for
maintaining long-term forest microclimate measurements. We would also
like to thank Warren Evans for sample processing and William Rugh for
isotopic analysis. Thanks to Ansgar Kahmen, Steve Voelker, John Roden,
and Bob Ozretich who provided comments on earlier versions of this
manuscript.
NR 47
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U1 9
U2 44
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0028-646X
J9 NEW PHYTOL
JI New Phytol.
PY 2011
VL 190
IS 3
BP 770
EP 782
DI 10.1111/j.1469-8137.2010.03627.x
PG 13
WC Plant Sciences
SC Plant Sciences
GA 751TX
UT WOS:000289641600026
PM 21284649
ER
PT J
AU Bandele, OJ
Wang, XT
Campbell, MR
Pittman, GS
Bell, DA
AF Bandele, Omari J.
Wang, Xuting
Campbell, Michelle R.
Pittman, Gary S.
Bell, Douglas A.
TI Human single-nucleotide polymorphisms alter p53 sequence-specific
binding at gene regulatory elements
SO NUCLEIC ACIDS RESEARCH
LA English
DT Article
ID BREAST-CANCER CELLS; TRANSCRIPTION-FACTOR; DNA-DAMAGE; HUMAN GENOME;
RESPONSE-ELEMENTS; PROMOTER; SITES; EXPRESSION; NETWORK; TARGETS
AB p53 coordinates the expression of an intricate network of genes in response to stress signals. Sequence-specific DNA binding is essential for p53-mediated tumor suppression. We evaluated the impact of single-nucleotide polymorphisms (SNPs) in p53 response elements (p53RE) on DNA binding and gene expression in response to DNA damage. Using a bioinformatics approach based on incorporating p53 binding strength into a position weight matrix, we selected 32 SNPs in putative and validated p53REs. The microsphere assay for protein-DNA binding (MAPD) and allele-specific expression analysis was employed to assess the impact of SNPs on p53-DNA binding and gene expression, respectively. Comparing activated p53 binding in nuclear extracts from doxorubicin- or ionizing radiation (IR)-treated human cells, we observed little difference in binding profiles. Significant p53 binding was observed for most polymorphic REs and several displayed binding comparable to the p21 RE. SNP alleles predicted to lower p53 binding indeed reduced binding in 25 of the 32 sequences. Chromatin immunoprecipitation-sequencing in lymphoblastoid cells confirmed p53 binding to seven polymorphic p53 REs in response to doxorubicin. In addition, five polymorphisms were associated with altered gene expression following doxorubicin treatment. Our findings demonstrate an effective strategy to identify and evaluate SNPs that may alter p53-mediated stress responses.
C1 [Bandele, Omari J.; Wang, Xuting; Campbell, Michelle R.; Pittman, Gary S.; Bell, Douglas A.] Natl Inst Environm Hlth Sci, Environm Genom Grp, Mol Genet Lab, NIH, Res Triangle Pk, NC 27709 USA.
RP Bell, DA (reprint author), Natl Inst Environm Hlth Sci, Environm Genom Grp, Mol Genet Lab, NIH, Res Triangle Pk, NC 27709 USA.
EM bell1@niehs.nih.gov
OI Wang, Xuting/0000-0001-6781-8008
FU National Institute of Environmental Health Sciences, National Institutes
of Health [ZO1-ES-100475-M-0001, ZO1-ES065079-15]; National Institute of
Environmental Health Sciences
FX The Intramural Research Program of the National Institute of
Environmental Health Sciences, National Institutes of Health
(ZO1-ES-100475-M-0001 and ZO1-ES065079-15). Funding for open access
charge: The Intramural Research Program, National Institute of
Environmental Health Sciences.
NR 54
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U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0305-1048
J9 NUCLEIC ACIDS RES
JI Nucleic Acids Res.
PD JAN
PY 2011
VL 39
IS 1
BP 178
EP 189
DI 10.1093/nar/gkq764
PG 12
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 703VD
UT WOS:000286008500019
PM 20817676
ER
PT S
AU Heindel, JJ
AF Heindel, Jerrold J.
BE Lustig, RH
TI The Obesogen Hypothesis of Obesity: Overview and Human Evidence
SO OBESITY BEFORE BIRTH: MATERNAL AND PRENATAL INFLUENCES ON THE OFFSPRING
SE Endocrine Updates
LA English
DT Article; Book Chapter
ID MATERNAL SMOKING; INTRAUTERINE EXPOSURE; DEVELOPMENTAL ORIGINS;
METABOLIC SYNDROME; CHILD OVERWEIGHT; PREGNANCY; HEALTH; FETAL;
FRUCTOSE; DISEASE
C1 Natl Inst Environm Hlth Sci, Div Extramural Res & Training, Res Triangle Pk, NC USA.
RP Heindel, JJ (reprint author), Natl Inst Environm Hlth Sci, Div Extramural Res & Training, Res Triangle Pk, NC USA.
EM heindelj@niehs.nih.gov
NR 46
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U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
SN 1566-0729
BN 978-1-4419-7033-6
J9 ENDOCR UPDAT
PY 2011
BP 355
EP 365
DI 10.1007/978-1-4419-7034-3_17
D2 10.1007/978-1-4419-7034-3
PG 11
WC Endocrinology & Metabolism; Obstetrics & Gynecology
SC Endocrinology & Metabolism; Obstetrics & Gynecology
GA BRK21
UT WOS:000282900300017
ER
PT J
AU Nichols, WJ
AF Nichols, William J.
BE Fingas, M
TI The United States Environmental Protection Agency: National Oil and
Hazardous Substances Pollution Contingency Plan, Subpart J Product
Schedule (40 Code of Federal Regulations 300.900)
SO OIL SPILL SCIENCE AND TECHNOLOGY: PREVENTION, RESPONSE, AND CLEANUP
LA English
DT Article; Book Chapter
C1 [Nichols, William J.] US EPA, OEM, Washington, DC USA.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU GULF PROFESSIONAL PUBL
PI OXFORD
PA C/O ELSEVIER LINACRE HOUSE JORDAN HILL, OXFORD, 0X2 8DP, ENGLAND
BN 978-1-85617-944-7
PY 2011
BP 673
EP 682
DI 10.1016/B978-1-85617-943-0.10020-6
PG 10
WC Energy & Fuels; Engineering, Environmental; Environmental Sciences
SC Energy & Fuels; Engineering; Environmental Sciences & Ecology
GA BGM65
UT WOS:000323513500021
ER
PT S
AU Moore, MT
Kroger, R
Farris, JL
Locke, MA
Bennett, ER
Denton, DL
Cooper, CM
AF Moore, M. T.
Kroeger, R.
Farris, J. L.
Locke, M. A.
Bennett, E. R.
Denton, D. L.
Cooper, C. M.
BE Goh, KS
Bret, BL
Potter, TL
Gan, J
TI From Vegetated Ditches to Rice Fields: Thinking Outside the Box for
Pesticide Mitigation
SO PESTICIDE MITIGATION STRATEGIES FOR SURFACE WATER QUALITY
SE ACS Symposium Series
LA English
DT Proceedings Paper
CT 239th National Meeting of the American-Chemical-Society
CY MAR 21-25, 2010
CL San Francisco, CA
SP Amer Chem Soc, Div Chem Educ, Amer Chem Soc, Div Carbohydrate Chem, Amer Chem Soc, Sustainable Theme Comm, Amer Sugar Cane League, V Lab Inc, Amer Chem Soc
ID CONSTRUCTED WETLANDS; AGRICULTURAL RUNOFF; DRAINAGE DITCHES; MISSISSIPPI
DELTA; ATRAZINE
AB Pesticide contamination of surface waters has been a global concern for decades. In agricultural areas, pesticides enter receiving waters through irrigation and storm runoff, spray drift, or even atmospheric deposition. Management practices incorporating vegetation and phytoremediation have demonstrated success in reducing pesticide loads to rivers, lakes, and streams. This chapter will focus on a variety of vegetative management practices (e.g. constructed wetlands, drainage ditches, and rice fields) which have been studied in the intensively cultivated Mississippi Delta. Summaries of research results will be presented, as well as potential future directions for additional research.
C1 [Moore, M. T.; Locke, M. A.; Cooper, C. M.] USDA ARS, Natl Sedimentat Lab, Oxford, MS 38655 USA.
[Kroeger, R.] Mississippi State Univ, Dept Wildlife Fisheries & Aquaculture, Mississippi State, MS 39762 USA.
[Farris, J. L.] Arkansas State Univ, Arkansas Biosci Inst, State Univ, AR 72467 USA.
[Bennett, E. R.] Bioengn Grp, Salem, MA 01970 USA.
[Denton, D. L.] US Environm Protect Agcy, Region 9, Sacramento, CA 95814 USA.
RP Moore, MT (reprint author), USDA ARS, Natl Sedimentat Lab, Oxford, MS 38655 USA.
EM matt.moore@ars.usda.gov
NR 24
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Z9 2
U1 0
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA
SN 0097-6156
BN 978-0-8412-2656-2
J9 ACS SYM SER
JI ACS Symp. Ser.
PY 2011
VL 1075
BP 29
EP +
PG 3
WC Agricultural Engineering; Water Resources
SC Agriculture; Water Resources
GA BDF53
UT WOS:000313022200002
ER
PT S
AU David, N
Thomas, F
Denton, D
AF David, Nicole
Thomas, Fred
Denton, Debra
BE Goh, KS
Bret, BL
Potter, TL
Gan, J
TI Comparison of Pesticide Runoff from Organic and Conventional Walnut
Orchards
SO PESTICIDE MITIGATION STRATEGIES FOR SURFACE WATER QUALITY
SE ACS Symposium Series
LA English
DT Proceedings Paper
CT 239th National Meeting of the American-Chemical-Society
CY MAR 21-25, 2010
CL San Francisco, CA
SP Amer Chem Soc, Div Chem Educ, Amer Chem Soc, Div Carbohydrate Chem, Amer Chem Soc, Sustainable Theme Comm, Amer Sugar Cane League, V Lab Inc, Amer Chem Soc
DE organophosphate pesticides; pyrethroids; agricultural runoff; organic;
walnuts
ID PYRETHROIDS; CALIFORNIA
AB Contamination from pesticide and nutrient applications to orchard crops is a major water quality issue in California. The goals of this study were to compare pesticide concentrations in water and sediment in runoff from organic and conventional walnut orchards and to compare the observed concentrations to water quality criteria and aquatic life benchmarks. Water and sediment samples were collected from five orchards over two years. Slightly lower, but not significantly different, pesticide concentrations for several pesticides (chlorpyrifos, diazinon, dimethoate, lambda-cyhalothrin, and esfenvalerate) in runoff from organic orchards were measured compared to the conventional orchards. Average concentrations of bifenthrin in sediment were statistically significantly lower (p < 0.05) at the organic sites compared to the conventional sites. This work indicates that BMP implementation and organic farming practices are effective in minimizing concentrations of pesticides in orchard runoff.
C1 [David, Nicole] San Francisco Estuary Inst, 7770 Pardee Lane,2nd Floor, Oakland, CA 94621 USA.
[Thomas, Fred] CERUS Consulting, Chico, CA 95926 USA.
[Denton, Debra] US Environm Protect Agcy, Sacramento, CA 95814 USA.
RP David, N (reprint author), San Francisco Estuary Inst, 7770 Pardee Lane,2nd Floor, Oakland, CA 94621 USA.
EM nicoled@sfei.org
NR 9
TC 0
Z9 0
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA
SN 0097-6156
BN 978-0-8412-2656-2
J9 ACS SYM SER
JI ACS Symp. Ser.
PY 2011
VL 1075
BP 129
EP +
PG 2
WC Agricultural Engineering; Water Resources
SC Agriculture; Water Resources
GA BDF53
UT WOS:000313022200009
ER
PT S
AU Luo, YZ
Williams, WM
Young, DF
Watanabe, H
Boulange, J
Ritter, AM
Phong, TK
AF Luo, Yuzhou
Williams, W. Martin
Young, Dirk F.
Watanabe, Hirozumi
Boulange, Julien
Ritter, Amy M.
Thai Khanh Phong
BE Goh, KS
Bret, BL
Potter, TL
Gan, J
TI Modeling Approaches for Pesticide Exposure Assessment in Rice Paddies
SO PESTICIDE MITIGATION STRATEGIES FOR SURFACE WATER QUALITY
SE ACS Symposium Series
LA English
DT Proceedings Paper
CT 239th National Meeting of the American-Chemical-Society
CY MAR 21-25, 2010
CL San Francisco, CA
SP Amer Chem Soc, Div Chem Educ, Amer Chem Soc, Div Carbohydrate Chem, Amer Chem Soc, Sustainable Theme Comm, Amer Sugar Cane League, V Lab Inc, Amer Chem Soc
ID IV FUGACITY MODEL; MANAGEMENT PRACTICE; RISK-ASSESSMENT; VADOFT MODEL;
SIMULATION-MODEL; SURFACE SOIL; WATER; FATE; RUNOFF; FIELDS
AB Pesticide use in paddy rice production may contribute to adverse ecological effects in surface waters. Risk assessments conducted for regulatory purposes depend on the use of simulation models to determine predicted environment concentrations (PEC) of pesticides. Often tiered approaches are used, in which assessments at lower tiers are based on relatively simple models with conservative scenarios, while those at higher tiers have more realistic representations of physical and biochemical processes. This chapter reviews models commonly used for predicting the environmental fate of pesticides in rice paddies. Theoretical considerations, unique features, and applications are discussed. This review is expected to provide information to guide model selection for pesticide registration, regulation, and mitigation in rice production areas.
C1 [Luo, Yuzhou] Calif Environm Protect Agcy, Dept Pesticide Regulat, Sacramento, CA 95812 USA.
[Williams, W. Martin; Ritter, Amy M.] Waterborne Environm Inc, Leesburg, VA 20175 USA.
[Young, Dirk F.] Off Pesticides, US Environm Protect Agcy, Washington, DC 20460 USA.
[Watanabe, Hirozumi; Boulange, Julien] Tokyo Univ Agr & Technol, Fuchu, Tokyo 1838509, Japan.
[Thai Khanh Phong] Univ Queensland, Natl Res Ctr Environm Toxicol, Brisbane, Qld 4108, Australia.
RP Luo, YZ (reprint author), Calif Environm Protect Agcy, Dept Pesticide Regulat, Sacramento, CA 95812 USA.
EM yluo@cdpr.ca.gov
RI Thai, Phong/A-3998-2011;
OI Thai, Phong/0000-0003-0042-3057; Luo, Yuzhou/0000-0003-0879-9622
NR 63
TC 1
Z9 1
U1 0
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA
SN 0097-6156
BN 978-0-8412-2656-2
J9 ACS SYM SER
JI ACS Symp. Ser.
PY 2011
VL 1075
BP 203
EP +
PG 6
WC Agricultural Engineering; Water Resources
SC Agriculture; Water Resources
GA BDF53
UT WOS:000313022200014
ER
PT S
AU Moran, KD
TenBrook, PL
AF Moran, Kelly D.
TenBrook, Patti L.
BE Goh, KS
Bret, BL
Potter, TL
Gan, J
TI Sources of Pyrethroid Insecticides in California's Urban Watersheds: A
Conceptual Model
SO PESTICIDE MITIGATION STRATEGIES FOR SURFACE WATER QUALITY
SE ACS Symposium Series
LA English
DT Proceedings Paper
CT 239th National Meeting of the American-Chemical-Society
CY MAR 21-25, 2010
CL San Francisco, CA
SP Amer Chem Soc, Div Chem Educ, Amer Chem Soc, Div Carbohydrate Chem, Amer Chem Soc, Sustainable Theme Comm, Amer Sugar Cane League, V Lab Inc, Amer Chem Soc
ID RESOLUTION MASS-SPECTROMETRY; SEDIMENT TOXICITY; PIPERONYL BUTOXIDE;
PESTICIDES; USA; WATERWAYS; ESTUARY; CREEKS
AB Pyrethroid insecticides have been linked to widespread aquatic toxicity in California's urban watersheds. To assist with the identification of the specific applications or activities linked to pyrethroids discharges, a conceptual model of the transport of pyrethroids from urban areas to surface waters was developed. This model is based on a review of scientific and engineering literature, pesticide product labels, California pesticide sales and reported use data, pesticide user surveys, and unpublished data from municipal urban runoff programs and municipal wastewater treatment plants. The conceptual model categorizes urban pesticide use patterns and disposal practices, and identifies pathways linking pesticide applications with surface waters. The model assumes that the bulk of pesticide applications are made to sites specified on product labels, but considers both legal and illegal disposal practices. The model was developed to serve as a tool to prioritize further investigations of use patterns, formulations, and transport mechanisms, and to develop measures to prevent and respond to water quality and compliance problems associated with urban pyrethroid use.
C1 [Moran, Kelly D.] TDC Environm LLC, 4020 Bayview Ave, San Mateo, CA 94403 USA.
[TenBrook, Patti L.] US Environm Protect Agcy, San Francisco, CA 94105 USA.
RP Moran, KD (reprint author), TDC Environm LLC, 4020 Bayview Ave, San Mateo, CA 94403 USA.
EM kmoran@tdcenvironmental.com
FU California Stormwater Quality Association; American Recovery and
Reinvestment Act; Clean Water State Revolving Fund through California
State Water Resources Control Board
FX Development of this conceptual model was made possible in part by
funding from the California Stormwater Quality Association and a grant
from the American Recovery and Reinvestment Act of 2009 and the Clean
Water State Revolving Fund through the California State Water Resources
Control Board and the San Francisco Estuary Partnership. The contents of
this document do not necessarily reflect the views or policies of the
funding organizations. Although this chapter has been reviewed and
approved in accordance with U.S. EPA requirements, its contents do not
necessarily reflect U.S. EPA views or policy. Mention of trade names or
commercial products does not constitute endorsement or recommendation
for use. Special thanks to Dr. Gail Chesler for her peer review of the
wastewater portion of the model.
NR 67
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PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA
SN 0097-6156
BN 978-0-8412-2656-2
J9 ACS SYM SER
JI ACS Symp. Ser.
PY 2011
VL 1075
BP 287
EP +
PG 7
WC Agricultural Engineering; Water Resources
SC Agriculture; Water Resources
GA BDF53
UT WOS:000313022200018
ER
PT J
AU Moser, VC
AF Moser, Virginia C.
BE Stoytcheva, M
TI Age-Related Differences in Acetylcholinesterase Inhibition Produced by
Organophosphorus and N-Methyl Carbamate Pesticides
SO PESTICIDES IN THE MODERN WORLD - PESTS CONTROL AND PESTICIDES EXPOSURE
AND TOXICITY ASSESSMENT
LA English
DT Article; Book Chapter
ID GENDER-RELATED DIFFERENCES; ADULT-RATS; IN-VITRO; ESTERASE-ACTIVITIES;
ORAL CHLORPYRIFOS; ACUTE TOXICITY; TIME-COURSE; CHOLINESTERASE ACTIVITY;
PRESCHOOL-CHILDREN; DOSE-RESPONSE
C1 [Moser, Virginia C.] US EPA, Tox Assessment Div, NHEERL ORD, Res Triangle Pk, NC 27711 USA.
RP Moser, VC (reprint author), US EPA, Tox Assessment Div, NHEERL ORD, Res Triangle Pk, NC 27711 USA.
NR 57
TC 1
Z9 1
U1 0
U2 0
PU INTECH EUROPE
PI RIJEKA
PA JANEZA TRDINE9, RIJEKA, 51000, CROATIA
BN 978-953-307-457-3
PY 2011
BP 495
EP 506
D2 10.5772/948
PG 12
WC Agriculture, Multidisciplinary; Biotechnology & Applied Microbiology;
Environmental Sciences; Toxicology
SC Agriculture; Biotechnology & Applied Microbiology; Environmental
Sciences & Ecology; Toxicology
GA BG1KN
UT WOS:000386855800023
ER
PT J
AU Zepp, RG
Erickson, DJ
Paul, ND
Sulzberger, B
AF Zepp, R. G.
Erickson, D. J., III
Paul, N. D.
Sulzberger, B.
TI Effects of solar UV radiation and climate change on biogeochemical
cycling: interactions and feedbacks
SO PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
LA English
DT Review
ID DISSOLVED ORGANIC-MATTER; CARBON-MONOXIDE PHOTOPRODUCTION;
METHYL-BROMIDE ALTERNATIVES; PLANT LITTER DECOMPOSITION; ULTRAVIOLET-B
RADIATION; COASTAL SALT-MARSH; OCEAN ACIDIFICATION; METHANE EMISSIONS;
TERRESTRIAL PLANTS; SURFACE WATERS
AB Solar UV radiation, climate and other drivers of global change are undergoing significant changes and models forecast that these changes will continue for the remainder of this century. Here we assess the effects of solar UV radiation on biogeochemical cycles and the interactions of these effects with climate change, including feedbacks on climate. Such interactions occur in both terrestrial and aquatic ecosystems. While there is significant uncertainty in the quantification of these effects, they could accelerate the rate of atmospheric CO2 increase and subsequent climate change beyond current predictions. The effects of predicted changes in climate and solar UV radiation on carbon cycling in terrestrial and aquatic ecosystems are expected to vary significantly between regions. The balance of positive and negative effects on terrestrial carbon cycling remains uncertain, but the interactions between UV radiation and climate change are likely to contribute to decreasing sink strength in many oceanic regions. Interactions between climate and solar UV radiation will affect cycling of elements other than carbon, and so will influence the concentration of greenhouse and ozone-depleting gases. For example, increases in oxygen-deficient regions of the ocean caused by climate change are projected to enhance the emissions of nitrous oxide, an important greenhouse and ozone-depleting gas. Future changes in UV-induced transformations of aquatic and terrestrial contaminants could have both beneficial and adverse effects. Taken in total, it is clear that the future changes in UV radiation coupled with human-caused global change will have large impacts on biogeochemical cycles at local, regional and global scales.
C1 [Zepp, R. G.] US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA.
[Erickson, D. J., III] Oak Ridge Natl Lab, Comp Sci & Math Div, Computat Earth Sci Grp, Oak Ridge, TN 37831 USA.
[Paul, N. D.] Univ Lancaster, Lancaster Environm Ctr, Lancaster LA1 4YQ, England.
[Sulzberger, B.] Swiss Fed Inst Aquat Sci & Technol Eawag, CH-8600 Dubendorf, Switzerland.
RP Zepp, RG (reprint author), US EPA, Natl Exposure Res Lab, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM zepp.richard@epa.gov
RI Paul, Nigel/E-5350-2014
OI Paul, Nigel/0000-0001-6959-4239
NR 238
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U2 69
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1474-905X
EI 1474-9092
J9 PHOTOCH PHOTOBIO SCI
JI Photochem. Photobiol. Sci.
PY 2011
VL 10
IS 2
BP 261
EP 279
DI 10.1039/c0pp90037k
PG 19
WC Biochemistry & Molecular Biology; Biophysics; Chemistry, Physical
SC Biochemistry & Molecular Biology; Biophysics; Chemistry
GA 714UV
UT WOS:000286835400005
PM 21253663
ER
PT B
AU Brandesi, W
Themelis, NJ
AF Brandesi, William (Rick)
Themelis, Nickolas J.
GP ASME
TI MATERIALS AND ENERGY RECOVERY FROM MUNICIPAL SOLID WASTE: WHY THEY ARE
BOTH NEEDED
SO PROCEEDINGS OF THE 19TH ANNUAL NORTH AMERICAN WASTE TO ENERGY
CONFERENCE, NAWTEC19: ADVANCING WASTE TO ENERGY THROUGH RESEARCH AND
TECHNOLOGY
LA English
DT Proceedings Paper
CT 19th Annual North American Waste to Energy Conference (NAWTEC19)
CY MAY 16-18, 2011
CL Lancaster, PA
SP ASME, Solid Waste Process Div, Integral Waste Serv Assoc, Solid Waste Assoc N Amer
AB The United States is the largest generator of municipal solid waste (MSW) in the world. It also landfills the largest amount of MSW. In this article, the authors present a comprehensive argument for implementing a more sustainable approach to the management of MSW. This approach includes the significant expansion of energy recovery from MSW, both to avoid burying massive amounts of waste and to expand generation of renewable, carbon-efficient electricity.
C1 [Brandesi, William (Rick)] US EPA, Energy Recovery & Waste Management Branch, Off Resource Conservat & Recovery, Washington, DC USA.
[Themelis, Nickolas J.] Columbia Univ, Earth Engn Ctr, New York, NY 10027 USA.
RP Brandesi, W (reprint author), US EPA, Energy Recovery & Waste Management Branch, Off Resource Conservat & Recovery, Washington, DC USA.
NR 7
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PU AMER SOC MECHANICAL ENGINEERS
PI NEW YORK
PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA
BN 978-0-7918-5457-0
PY 2011
BP 127
EP +
PG 9
WC Energy & Fuels; Engineering, Environmental; Engineering, Mechanical
SC Energy & Fuels; Engineering
GA BFJ24
UT WOS:000320092800017
ER
PT J
AU Bohon, MD
Metzger, BA
Linak, WP
King, CJ
Roberts, WL
AF Bohon, Myles D.
Metzger, Brian A.
Linak, William P.
King, Charly J.
Roberts, William L.
TI Glycerol combustion and emissions
SO PROCEEDINGS OF THE COMBUSTION INSTITUTE
LA English
DT Article
DE Glycerol combustion; Emission characterization; Bio-fuels; Burner
development; Waste fuels
ID DISPERSED KAOLINITE POWDERS; FLAMES
AB With the growing capacity in biodiesel production and the resulting glut of the glycerol by-product, there is increasing interest in finding alternative uses for crude glycerol. One option may be to burn it locally for combined process heat and power, replacing fossil fuels and improving the economics of biodiesel production. However, due to its low energy density, high viscosity, and high auto-ignition temperature, glycerol is difficult to burn. Additionally, the composition of the glycerol by-product can change dramatically depending upon the biodiesel feedstock (e. g., vegetable oils or rendered animal fats), the catalyst used, and the degree of post-reaction cleanup (e. g., acidulation and demethylization). This paper reports the results of experiments to (1) develop a prototype high-swirl refractory burner designed for retrofit applications in commercial-scale fire-tube package boilers, and (2) provide an initial characterization of emissions generated during combustion of crude glycerol in a laboratory-scale moderate-swirl refractory- lined furnace. We report a range of emissions measurements, including nitrogen oxides, total hydrocarbons, and particle mass for two grades of crude glycerol (methylated and demethylated) and compare these to No. 2 fuel oil and propane. We also present preliminary data on the emissions of select carbonyls (by cartridge DNPH). Results indicate that a properly designed refractory burner can provide the thermal environment to effectively combust glycerol, but that high particulate emissions due to residual catalysts are likely to be an issue for crude glycerol combustion. (C) 2010 The Combustion Institute. Published by Elsevier Inc. All rights reserved.
C1 [Bohon, Myles D.; Metzger, Brian A.; Roberts, William L.] N Carolina State Univ, Dept Mech & Aerosp Engn, Raleigh, NC 27695 USA.
[Linak, William P.] US EPA, Air Pollut Prevent & Control Div, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
[King, Charly J.] ARCADIS Geraghty & Miller Inc, Durham, NC 27709 USA.
RP Bohon, MD (reprint author), Engn Bldg 3,Campus Box 7910,911 Oval Dr, Raleigh, NC 27695 USA.
EM mdbohon@ncsu.edu
FU Arcadis GM Inc. [EP-C-09-027]; NCSU/EPA; North Carolina State University
[CT8333235-01-0]; Diversified Energy Corporation; U.S. Environmental
Protection Agency through Office of Research and Development
FX Portion of this work were sponsored under Contract EP-C-09-027 with
Arcadis G&M Inc., the NCSU/EPA Cooperative Training Program in
Environmental Sciences Research, Training Agreement CT8333235-01-0 with
North Carolina State University, and funds from the Diversified Energy
Corporation. The authors would like to thank Seung-Hyun Cho and Daniel
Janek for their contributions. The U.S. Environmental Protection Agency
through its Office of Research and Development partially funded and
collaborated in the research described here. The views expressed by the
individual authors, however, are their own and do not necessarily
reflect those of the U. S. Environmental Protection Agency.
NR 14
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PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1540-7489
J9 P COMBUST INST
JI Proc. Combust. Inst.
PY 2011
VL 33
BP 2717
EP 2724
DI 10.1016/j.proci.2010.06.154
PN 2
PG 8
WC Thermodynamics; Energy & Fuels; Engineering, Chemical; Engineering,
Mechanical
SC Thermodynamics; Energy & Fuels; Engineering
GA 698XR
UT WOS:000285629000123
ER
PT J
AU Padilla, S
MacPhail, R
AF Padilla, Stephanie
MacPhail, Robert
BE Gupta, RC
TI Using zebrafish to assess developmental neurotoxicity
SO REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY
LA English
DT Article; Book Chapter
ID FETAL ALCOHOL SYNDROME; DANIO-RERIO; EMBRYONIC EXPOSURE; ETHANOL
EXPOSURE; LARVAL ZEBRAFISH; GENE-EXPRESSION; LATERAL-LINE; DRUG
DISCOVERY; HUMAN-DISEASE; MODEL SYSTEM
C1 [Padilla, Stephanie; MacPhail, Robert] US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
RP Padilla, S (reprint author), US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
NR 168
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U1 0
U2 1
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
BN 978-0-12-382033-4
PY 2011
BP 179
EP 191
DI 10.1016/B978-0-12-382032-7.10015-3
PG 13
WC Reproductive Biology; Toxicology
SC Reproductive Biology; Toxicology
GA BEX82
UT WOS:000318575300016
ER
PT J
AU Makris, SL
Glaberman, S
AF Makris, Susan L.
Glaberman, Scott
BE Gupta, RC
TI Developmental immunotoxicity testing
SO REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY
LA English
DT Article; Book Chapter
ID IMMUNE-SYSTEM DEVELOPMENT; CHILDRENS HEALTH-RISK; LYMPHOCYTE
SUBPOPULATIONS; CRITICAL WINDOWS; ADULT EXPOSURE; MOUSE EMBRYO; HUMAN
THYMUS; EARLY EVENTS; HUMAN-FETUS; EARLY-LIFE
C1 [Makris, Susan L.; Glaberman, Scott] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
RP Makris, SL (reprint author), US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
NR 69
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U2 0
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
BN 978-0-12-382033-4
PY 2011
BP 219
EP 225
DI 10.1016/B978-0-12-382032-7.10018-9
PG 7
WC Reproductive Biology; Toxicology
SC Reproductive Biology; Toxicology
GA BEX82
UT WOS:000318575300019
ER
PT J
AU Vulimiri, SV
Pratt, MM
Kulkarni, S
Beedanagari, S
Mahadevan, B
AF Vulimiri, Suryanarayana V.
Pratt, M. Margaret
Kulkarni, Shaila
Beedanagari, Sudheer
Mahadevan, Brinda
BE Gupta, RC
TI Reproductive and developmental toxicology: toxic solvents and gases
SO REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY
LA English
DT Article; Book Chapter
ID DRY-CLEANING WORKERS; MATERNAL OCCUPATIONAL-EXPOSURE; SUBCHRONIC
INHALATION TOXICITY; REINFORCED-PLASTICS COMPANIES; UNLEADED GASOLINE
VAPOR; CARBON-TETRACHLORIDE; ORGANIC-SOLVENTS; FORMALDEHYDE EXPOSURE;
SPONTANEOUS-ABORTIONS; INHALED FORMALDEHYDE
C1 [Vulimiri, Suryanarayana V.; Pratt, M. Margaret] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
[Kulkarni, Shaila] Merck Res Labs, Immunotoxicol Mech & Predict Toxicol, Summit, NJ USA.
[Beedanagari, Sudheer] Lexicon Pharmaceut, The Woodlands, TX USA.
[Mahadevan, Brinda] Merck Res Labs, Genet Toxicol Mech & Predict Toxicol, Summit, NJ USA.
RP Vulimiri, SV (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
OI Vulimiri, Suryanarayana/0000-0003-3734-0036
NR 141
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U2 5
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
BN 978-0-12-382033-4
PY 2011
BP 303
EP 315
DI 10.1016/B978-0-12-382032-7.10023-2
PG 13
WC Reproductive Biology; Toxicology
SC Reproductive Biology; Toxicology
GA BEX82
UT WOS:000318575300024
ER
PT B
AU Kodavanti, PRS
Szabo, DT
Stoker, TE
Fenton, SE
AF Kodavanti, Prasada Rao S.
Szabo, David T.
Stoker, Tammy E.
Fenton, Suzanne E.
BE Gupta, RC
TI Brominated flame retardants
SO REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY
LA English
DT Article; Book Chapter
ID POLYBROMINATED DIPHENYL ETHERS; SPRAGUE-DAWLEY RATS;
POLYCHLORINATED-BIPHENYLS PCBS; NEONATAL BRAIN-DEVELOPMENT; JUVENILE
RAINBOW-TROUT; THYROID-HORMONE LEVELS; DIBENZO-P-DIOXINS; IN-VITRO;
DECABROMODIPHENYL ETHER; DEVELOPMENTAL EXPOSURE
C1 [Kodavanti, Prasada Rao S.] US EPA, Neurotoxicol Branch, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab,Off Res &, Res Triangle Pk, NC 27711 USA.
[Szabo, David T.] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC USA.
[Szabo, David T.] US EPA, Integrated Syst Toxicol Div, Phamacokinet Branch, Natl Hlth & Environm Effects Res Lab,Off Res & De, Res Triangle Pk, NC 27711 USA.
[Stoker, Tammy E.] US EPA, Endocrine Toxicol Branch, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab,Off Res & D, Res Triangle Pk, NC 27711 USA.
[Fenton, Suzanne E.] NIEHS, Natl Toxicol Program, Res Triangle Pk, NC 27709 USA.
RP Kodavanti, PRS (reprint author), US EPA, Neurotoxicol Branch, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab,Off Res &, Res Triangle Pk, NC 27711 USA.
NR 176
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U2 3
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
BN 978-0-12-382033-4; 978-0-12-382032-7
PY 2011
BP 523
EP 541
PG 19
WC Reproductive Biology; Toxicology
SC Reproductive Biology; Toxicology
GA BEX82
UT WOS:000318575300041
ER
PT J
AU Doherty, JD
Irwin, WA
AF Doherty, John D.
Irwin, William A.
BE Gupta, RC
TI Organotins (tributyltin and triphenyltin)
SO REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY
LA English
DT Article; Book Chapter
ID 2-GENERATION REPRODUCTIVE TOXICITY; CLAMS MYA-ARENARIA; IN-UTERO
EXPOSURE; AROMATASE-ACTIVITY; ADIPOCYTE DIFFERENTIATION; DEVELOPMENTAL
TOXICITY; OXIDATIVE-PHOSPHORYLATION; DIBUTYLTIN DICHLORIDE; POSTNATAL
EXPOSURE; CYNOMOLGUS MONKEYS
C1 [Doherty, John D.; Irwin, William A.] US EPA, Div Hlth Effects, Off Chem Safety & Pollut Prevent, Washington, DC 20460 USA.
RP Doherty, JD (reprint author), US EPA, Div Hlth Effects, Off Chem Safety & Pollut Prevent, Washington, DC 20460 USA.
NR 99
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U2 2
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
BN 978-0-12-382033-4
PY 2011
BP 657
EP 672
DI 10.1016/B978-0-12-382032-7.10049-9
PG 16
WC Reproductive Biology; Toxicology
SC Reproductive Biology; Toxicology
GA BEX82
UT WOS:000318575300050
ER
PT J
AU Santos-Ahmed, J
Brown, C
Smith, SD
Weston, P
Rasoulpour, T
Gilbert, ME
Hixon, ML
AF Santos-Ahmed, Jeena
Brown, Caitlin
Smith, Stuart Duncan
Weston, Paula
Rasoulpour, Teresa
Gilbert, Mary E.
Hixon, Mary L.
TI Akt1 protects against germ cell apoptosis in the postnatal mouse testis
following lactational exposure to 6-N-propylthiouracil
SO REPRODUCTIVE TOXICOLOGY
LA English
DT Article
DE Akt1; Sertoli cell; Germ cell; Transient postnatal hypothyroidism;
Propylthiouracil
ID NEONATAL GOITROGEN TREATMENT; RAT SERTOLI-CELLS; THYROID-HORMONE; SPERM
PRODUCTION; SIGNALING PATHWAY; ORGAN GROWTH; ADULT-RATS; IN-VIVO;
HYPOTHYROIDISM; EXPRESSION
AB Exposure to 6-propyl-2-thio-uracil (PTU), a neonatal goitrogen, leads to increased testis size and sperm production in rodents. Akt1, a gene involved in cell survival and proliferation is also phosphorylated by thyroxine (T(4)). Therefore, we examined the requirement for Akt1 in germ cell survival following PTU-induced hypothyroidism. Experiments were performed using Akt1+/+, Akt1+/-, and Akt1-/- mice. PTU was administered (0.01% w/v) via the drinking water of dams from birth to PND21. At PND15,T(4) serum levels were similar in all control groups, and significantly lower in all exposed groups with a dramatic decrease in Akt1-/- mice. PTU-exposed Akt1-/- testes displayed smaller tubules, increased apoptosis, delayed lumen formation, and increased inhibin B and AMH mRNA. Relative adult testis weights were similar in all exposure groups: however, no increase in daily sperm production was observed in PTU-exposed Akt1-/- mice. In conclusion, Akt1 contributes to the effects of thyroid hormone on postnatal testis development. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Santos-Ahmed, Jeena; Brown, Caitlin; Smith, Stuart Duncan; Weston, Paula; Rasoulpour, Teresa; Hixon, Mary L.] Brown Univ, Dept Pathol & Lab Med, Providence, RI 02912 USA.
[Gilbert, Mary E.] US EPA, Div Neurotoxicol, Natl Hlth & Environm Effects Lab, Res Triangle Pk, NC 27711 USA.
RP Hixon, ML (reprint author), Brown Univ, Dept Pathol & Lab Med, GE505, Providence, RI 02912 USA.
EM Hixon@Brown.edu
FU NIEHS/NIH [ES015704]
FX This research was supported by ES015704 from the NIEHS/NIH to M.H.
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0890-6238
J9 REPROD TOXICOL
JI Reprod. Toxicol.
PD JAN
PY 2011
VL 31
IS 1
BP 17
EP 25
DI 10.1016/j.reprotox.2010.09.012
PG 9
WC Reproductive Biology; Toxicology
SC Reproductive Biology; Toxicology
GA 724DI
UT WOS:000287555900003
PM 20951798
ER
PT J
AU Narotsky, MG
Best, DS
McDonald, A
Godin, EA
Hunter, ES
Simmons, JE
AF Narotsky, Michael G.
Best, Deborah S.
McDonald, Anthony
Godin, Elizabeth A.
Hunter, E. Sidney, III
Simmons, Jane Ellen
TI Pregnancy loss and eye malformations in offspring of F344 rats following
gestational exposure to mixtures of regulated trihalomethanes and
haloacetic acids
SO REPRODUCTIVE TOXICOLOGY
LA English
DT Article
DE Disinfection by-products; Trihalomethanes; Haloacetic acids; Mixtures;
Developmental toxicity; Pregnancy loss; Anophthalmia
ID DISINFECTION BY-PRODUCTS; INVIVO TERATOLOGY SCREEN; PUBLIC
WATER-SUPPLIES; DEVELOPMENTAL TOXICITY; DRINKING-WATER; BIRTH-WEIGHT;
BROMODICHLOROMETHANE BDCM; CARBON-TETRACHLORIDE; CHLORINATION;
OZONATION/POSTCHLORINATION
AB Chlorination of drinking water yields hundreds of disinfection by-products (DBPs). Among the DBPs, four trihalomethanes (THMs; chloroform, bromodichloromethane, chlorodibromomethane, bromoform) and five haloacetic acids (HAAs; chloroacetic, dichloroacetic, trichloroacetic, bromoacetic, and dibromoacetic acid) are U.S. EPA regulated. We assessed the combined toxicity of these DBPs. F344 rats were treated with mixtures of the four THMs (THM4), the five HAAs (HAA5), or nine DBPs (DBP9; THM4 + HAAS). Mixtures were administered in 10% Alkamuls (R) EL-620 daily by gavage on gestation days 6-20. Litters were examined postnatally. All three mixtures caused pregnancy loss at >= 613 mu mol/kg/day. In surviving litters, resorption rates were increased in groups receiving HAA5 at 615 mu mol/kg/day and DBP9 at 307 mu mol/kg/day. HAA5 caused eye malformations (anophthalmia, microphthalmia) at >= 308 mu mol/kg/day. Thus, both HAAs and THMs contributed to DBP9-induced pregnancy loss. The presence of THMs in the full mixture, however, appeared to reduce the incidence of HAA-induced eye defects. Published by Elsevier Inc.
C1 [Narotsky, Michael G.] US EPA, NHEERL MD 67, Natl Hlth & Environm Effects Res Lab, Tox Assessment Div,ORD, Res Triangle Pk, NC 27711 USA.
[McDonald, Anthony; Simmons, Jane Ellen] US EPA, ORD, Natl Hlth & Environm Effects Res Lab, Integrated Syst Toxicol Div, Res Triangle Pk, NC 27711 USA.
[Godin, Elizabeth A.] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC USA.
RP Narotsky, MG (reprint author), US EPA, NHEERL MD 67, Natl Hlth & Environm Effects Res Lab, Tox Assessment Div,ORD, Res Triangle Pk, NC 27711 USA.
EM narotsky.michael@epa.gov
FU U.S. Environmental Protection Agency; National Institutes of Health
[T32-ES07126]
FX The information in this document has been funded wholly by the U.S.
Environmental Protection Agency. It has been subjected to review by the
National Health and Environmental Effects Research Laboratory and
approved for publication. Approval does not signify that the contents
reflect the views of the Agency, nor does mention of trade name or
commercial products constitute endorsement or recommendation for use.;
Funding in support of E.A.G. was provided by the National Institutes of
Health, Training Grant T32-ES07126.
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0890-6238
J9 REPROD TOXICOL
JI Reprod. Toxicol.
PD JAN
PY 2011
VL 31
IS 1
BP 59
EP 65
DI 10.1016/j.reprotox.2010.08.002
PG 7
WC Reproductive Biology; Toxicology
SC Reproductive Biology; Toxicology
GA 724DI
UT WOS:000287555900008
PM 20850520
ER
PT J
AU Samet, JM
Olshan, AF
AF Samet, Jonathan M.
Olshan, Andrew F.
CA Comm Review EPAs Draft IRIS
GP Natl Res Council
TI REVIEW OF THE ENVIRONMENTAL PROTECTION AGENCY'S DRAFT IRIS ASSESSMENT OF
FORMALDEHYDE Summary
SO REVIEW OF THE ENVIRONMENTAL PROTECTION AGENCY'S DRAFT IRIS ASSESSMENT OF
FORMALDEHYDE
LA English
DT Editorial Material; Book Chapter
ID EXPOSURE; INDUSTRIES; MORTALITY; CHILDREN; WORKERS; HOMES; RISK
C1 [Samet, Jonathan M.] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
[Samet, Jonathan M.] USC Inst Global Hlth, Los Angeles, CA USA.
[Samet, Jonathan M.] US EPA, Sci Advisory Board, Washington, DC USA.
[Samet, Jonathan M.] CNR, Ottawa, ON, Canada.
[Olshan, Andrew F.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.
[Olshan, Andrew F.] Natl Res Council Comm Contaminated Drinking Water, Ottawa, ON, Canada.
RP Samet, JM (reprint author), Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
NR 10
TC 0
Z9 0
U1 0
U2 0
PU NATL ACADEMIES PRESS
PI WASHINGTON
PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA
BN 978-0-309-21193-2
PY 2011
BP 3
EP 15
PG 13
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA BC7ID
UT WOS:000354894100002
ER
PT J
AU Samet, JM
Olshan, AF
AF Samet, Jonathan M.
Olshan, Andrew F.
CA Comm Review EPAs Draft IRIS
GP Natl Res Council
TI REVIEW OF THE ENVIRONMENTAL PROTECTION AGENCY'S DRAFT IRIS ASSESSMENT OF
FORMALDEHYDE Preface
SO REVIEW OF THE ENVIRONMENTAL PROTECTION AGENCY'S DRAFT IRIS ASSESSMENT OF
FORMALDEHYDE
LA English
DT Editorial Material; Book Chapter
C1 [Samet, Jonathan M.] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
[Samet, Jonathan M.] USC Inst Global Hlth, Los Angeles, CA USA.
[Samet, Jonathan M.] US EPA, Sci Advisory Board, Washington, DC USA.
[Samet, Jonathan M.] CNR, Ottawa, ON, Canada.
[Olshan, Andrew F.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.
[Olshan, Andrew F.] Natl Res Council Comm Contaminated Drinking Water, Ottawa, ON, Canada.
RP Samet, JM (reprint author), Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATL ACADEMIES PRESS
PI WASHINGTON
PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA
BN 978-0-309-21193-2
PY 2011
BP IX
EP X
PG 2
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA BC7ID
UT WOS:000354894100001
ER
PT J
AU Samet, JM
Olshan, AF
AF Samet, Jonathan M.
Olshan, Andrew F.
CA Comm Review EPAs Draft IRIS
GP Natl Res Council
TI REVIEW OF THE ENVIRONMENTAL PROTECTION AGENCY'S DRAFT IRIS ASSESSMENT OF
FORMALDEHYDE Introduction
SO REVIEW OF THE ENVIRONMENTAL PROTECTION AGENCY'S DRAFT IRIS ASSESSMENT OF
FORMALDEHYDE
LA English
DT Editorial Material; Book Chapter
C1 [Samet, Jonathan M.] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
[Samet, Jonathan M.] USC Inst Global Hlth, Los Angeles, CA USA.
[Samet, Jonathan M.] US EPA, Sci Advisory Board, Washington, DC USA.
[Samet, Jonathan M.] CNR, Ottawa, ON, Canada.
[Olshan, Andrew F.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.
[Olshan, Andrew F.] Natl Res Council Comm Contaminated Drinking Water, Ottawa, ON, Canada.
RP Samet, JM (reprint author), Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
NR 8
TC 0
Z9 0
U1 0
U2 0
PU NATL ACADEMIES PRESS
PI WASHINGTON
PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA
BN 978-0-309-21193-2
PY 2011
BP 16
EP 23
PG 8
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA BC7ID
UT WOS:000354894100003
ER
PT J
AU Samet, JM
Olshan, AF
AF Samet, Jonathan M.
Olshan, Andrew F.
CA Comm Review EPAs Draft IRIS
GP Natl Res Council
TI Review of Methods
SO REVIEW OF THE ENVIRONMENTAL PROTECTION AGENCY'S DRAFT IRIS ASSESSMENT OF
FORMALDEHYDE
LA English
DT Review; Book Chapter
C1 [Samet, Jonathan M.] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
[Samet, Jonathan M.] USC Inst Global Hlth, Los Angeles, CA USA.
[Samet, Jonathan M.] US EPA, Sci Advisory Board, Washington, DC USA.
[Samet, Jonathan M.] CNR, Ottawa, ON, Canada.
[Olshan, Andrew F.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.
[Olshan, Andrew F.] Natl Res Council Comm Contaminated Drinking Water, Ottawa, ON, Canada.
RP Samet, JM (reprint author), Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
NR 8
TC 0
Z9 0
U1 0
U2 0
PU NATL ACADEMIES PRESS
PI WASHINGTON
PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA
BN 978-0-309-21193-2
PY 2011
BP 24
EP 28
PG 5
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA BC7ID
UT WOS:000354894100004
ER
PT J
AU Samet, JM
Olshan, AF
AF Samet, Jonathan M.
Olshan, Andrew F.
CA Comm Review EPAs Draft IRIS
GP Natl Res Council
TI Toxicokinetics and Modes of Action of Formaldehyde
SO REVIEW OF THE ENVIRONMENTAL PROTECTION AGENCY'S DRAFT IRIS ASSESSMENT OF
FORMALDEHYDE
LA English
DT Article; Book Chapter
ID PROTEIN CROSS-LINKS; INDUCED RESPIRATORY CANCER; RAT NASAL PASSAGES;
INHALED FORMALDEHYDE; RHESUS-MONKEYS; CELL-PROLIFERATION; COVALENT
BINDING; FLUX PREDICTIONS; SENSITIVITY-ANALYSIS; FISCHER-344 RATS
C1 [Samet, Jonathan M.] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
[Samet, Jonathan M.] USC Inst Global Hlth, Los Angeles, CA USA.
[Samet, Jonathan M.] US EPA, Sci Advisory Board, Washington, DC USA.
[Samet, Jonathan M.] CNR, Ottawa, ON, Canada.
[Olshan, Andrew F.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.
[Olshan, Andrew F.] Natl Res Council Comm Contaminated Drinking Water, Ottawa, ON, Canada.
RP Samet, JM (reprint author), Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
NR 58
TC 0
Z9 0
U1 0
U2 0
PU NATL ACADEMIES PRESS
PI WASHINGTON
PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA
BN 978-0-309-21193-2
PY 2011
BP 29
EP 63
PG 35
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA BC7ID
UT WOS:000354894100005
ER
PT J
AU Samet, JM
Olshan, AF
AF Samet, Jonathan M.
Olshan, Andrew F.
CA Comm Review EPAs Draft IRIS
GP Natl Res Council
TI Portal-of-Entry Health Effects
SO REVIEW OF THE ENVIRONMENTAL PROTECTION AGENCY'S DRAFT IRIS ASSESSMENT OF
FORMALDEHYDE
LA English
DT Article; Book Chapter
ID NATIONAL-CANCER-INSTITUTE; FORMALDEHYDE EXPOSURE; NASOPHARYNGEAL CANCER;
SENSORY IRRITATION; OCCUPATIONAL-EXPOSURE; WOOD DUST; RESPIRATORY
SYMPTOMS; DOMESTIC EXPOSURE; CHEMICAL WORKERS; SINONASAL CANCER
C1 [Samet, Jonathan M.] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
[Samet, Jonathan M.] USC Inst Global Hlth, Los Angeles, CA USA.
[Samet, Jonathan M.] US EPA, Sci Advisory Board, Washington, DC USA.
[Samet, Jonathan M.] CNR, Ottawa, ON, Canada.
[Olshan, Andrew F.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.
[Olshan, Andrew F.] Natl Res Council Comm Contaminated Drinking Water, Ottawa, ON, Canada.
RP Samet, JM (reprint author), Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
NR 58
TC 0
Z9 0
U1 0
U2 0
PU NATL ACADEMIES PRESS
PI WASHINGTON
PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA
BN 978-0-309-21193-2
PY 2011
BP 64
EP 91
PG 28
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA BC7ID
UT WOS:000354894100006
ER
PT J
AU Samet, JM
Olshan, AF
AF Samet, Jonathan M.
Olshan, Andrew F.
CA Comm Review EPAs Draft IRIS
GP Natl Res Council
TI Systemic Health Effects
SO REVIEW OF THE ENVIRONMENTAL PROTECTION AGENCY'S DRAFT IRIS ASSESSMENT OF
FORMALDEHYDE
LA English
DT Article; Book Chapter
ID FORMALDEHYDE EXPOSURE; INHALED FORMALDEHYDE; HISTOLOGY TECHNICIANS;
RESPIRATORY SYMPTOMS; RATS; WORKERS; LEUKEMIA; METAANALYSIS; INHALATION;
MORTALITY
C1 [Samet, Jonathan M.] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
[Samet, Jonathan M.] USC Inst Global Hlth, Los Angeles, CA USA.
[Samet, Jonathan M.] US EPA, Sci Advisory Board, Washington, DC USA.
[Samet, Jonathan M.] CNR, Ottawa, ON, Canada.
[Olshan, Andrew F.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.
[Olshan, Andrew F.] Natl Res Council Comm Contaminated Drinking Water, Ottawa, ON, Canada.
RP Samet, JM (reprint author), Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
NR 54
TC 0
Z9 0
U1 0
U2 0
PU NATL ACADEMIES PRESS
PI WASHINGTON
PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA
BN 978-0-309-21193-2
PY 2011
BP 92
EP 117
PG 26
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA BC7ID
UT WOS:000354894100007
ER
PT J
AU Samet, JM
Olshan, AF
AF Samet, Jonathan M.
Olshan, Andrew F.
CA Comm Review EPAs Draft IRIS
GP Natl Res Council
TI Reference Concentrations for Noncancer Effects and Unit Risks for
Cancers
SO REVIEW OF THE ENVIRONMENTAL PROTECTION AGENCY'S DRAFT IRIS ASSESSMENT OF
FORMALDEHYDE
LA English
DT Article; Book Chapter
ID S-NITROSOGLUTATHIONE REDUCTASE; FORMALDEHYDE EXPOSURE; NASOPHARYNGEAL
CANCER; REDUCED FERTILITY; MOBILE HOMES; MORTALITY; WORKERS; ASTHMA;
COHORT; DEHYDROGENASE
C1 [Samet, Jonathan M.] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
[Samet, Jonathan M.] USC Inst Global Hlth, Los Angeles, CA USA.
[Samet, Jonathan M.] US EPA, Sci Advisory Board, Washington, DC USA.
[Samet, Jonathan M.] CNR, Ottawa, ON, Canada.
[Olshan, Andrew F.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.
[Olshan, Andrew F.] Natl Res Council Comm Contaminated Drinking Water, Ottawa, ON, Canada.
RP Samet, JM (reprint author), Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
NR 62
TC 0
Z9 0
U1 0
U2 0
PU NATL ACADEMIES PRESS
PI WASHINGTON
PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA
BN 978-0-309-21193-2
PY 2011
BP 118
EP 150
PG 33
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA BC7ID
UT WOS:000354894100008
ER
PT J
AU Samet, JM
Olshan, AF
AF Samet, Jonathan M.
Olshan, Andrew F.
CA Comm Review EPAs Draft IRIS
GP Natl Res Council
TI A Roadmap for Revision
SO REVIEW OF THE ENVIRONMENTAL PROTECTION AGENCY'S DRAFT IRIS ASSESSMENT OF
FORMALDEHYDE
LA English
DT Article; Book Chapter
ID METAANALYSIS; DISEASE
C1 [Samet, Jonathan M.] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
[Samet, Jonathan M.] USC Inst Global Hlth, Los Angeles, CA USA.
[Samet, Jonathan M.] US EPA, Sci Advisory Board, Washington, DC USA.
[Samet, Jonathan M.] CNR, Ottawa, ON, Canada.
[Olshan, Andrew F.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.
[Olshan, Andrew F.] Natl Res Council Comm Contaminated Drinking Water, Ottawa, ON, Canada.
RP Samet, JM (reprint author), Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
NR 15
TC 0
Z9 0
U1 0
U2 0
PU NATL ACADEMIES PRESS
PI WASHINGTON
PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA
BN 978-0-309-21193-2
PY 2011
BP 151
EP 167
PG 17
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA BC7ID
UT WOS:000354894100009
ER
PT J
AU Samet, JM
Olshan, AF
AF Samet, Jonathan M.
Olshan, Andrew F.
CA Comm Review EPAs Draft IRIS
GP Natl Res Council
TI Weight-of-Evidence Descriptions from US Environmental Protection Agency
Guidelines
SO REVIEW OF THE ENVIRONMENTAL PROTECTION AGENCY'S DRAFT IRIS ASSESSMENT OF
FORMALDEHYDE
LA English
DT Article; Book Chapter
ID RISK ASSESSMENT
C1 [Samet, Jonathan M.] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
[Samet, Jonathan M.] USC Inst Global Hlth, Los Angeles, CA USA.
[Samet, Jonathan M.] US EPA, Sci Advisory Board, Washington, DC USA.
[Samet, Jonathan M.] CNR, Ottawa, ON, Canada.
[Olshan, Andrew F.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.
[Olshan, Andrew F.] Natl Res Council Comm Contaminated Drinking Water, Ottawa, ON, Canada.
RP Samet, JM (reprint author), Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
NR 19
TC 0
Z9 0
U1 0
U2 0
PU NATL ACADEMIES PRESS
PI WASHINGTON
PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA
BN 978-0-309-21193-2
PY 2011
BP 174
EP 190
PG 17
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA BC7ID
UT WOS:000354894100010
ER
PT J
AU Vinson, MR
Angradi, TR
AF Vinson, M. R.
Angradi, T. R.
TI Stomach Emptiness in Fishes: Sources of Variation and Study Design
Implications
SO REVIEWS IN FISHERIES SCIENCE
LA English
DT Article
DE bioenergetics; diet; energy balance; feeding; food; stomach contents;
fish; collection methods
ID REEF FISHES; EMPTY; RUN
AB This study summarizes fish stomach content data from 369,000 fish from 402 species in 1,096 collections and reports on the percentage of individuals with empty stomachs. The mean percentage of individuals with empty stomachs among all species, locations, habitats, seasons, regions, and collection methods was 26.4%. Mean percentage of individuals with empty stomachs varied significantly among fish collection gear types, taxonomic orders, trophic groups, feeding behaviors, and habitats, and with species length at maturity. Most of the variation in percentage of individuals with empty stomachs was explained by species length at maturity, fish collection gear type, and two autecological factors: trophic group (piscivore percentage of individuals with empty stomachs non-piscivore percentage of individuals with empty stomachs) and feeding habitat (water column feeder percentage of individuals with empty stomachs benthic feeder percentage of individuals with empty stomachs). After accounting for variation with fish length, the percentage of individuals with empty stomachs did not vary with the stomach removal collection method (dissection vs. gastric lavage), feeding time (diurnal or nocturnal), or time of collection (day or night). The percentage of individuals with empty stomachs was similar between fresh and saltwater fish, but differed within finer habitat classifications and appeared to follow a general prey availability or productivity gradient: percentage of individuals with empty stomachs of open ocean collections estuary collections, lentic lotic, and pelagic littoral. Gear type (active or passive) was the most influential factor affecting the occurrence of empty stomachs that can be readily controlled by researchers.
C1 [Vinson, M. R.] US Geol Survey, Great Lakes Sci Ctr, Lake Super Biol Stn, Ashland, WI 54806 USA.
[Angradi, T. R.] US EPA, Off Res & Dev, Natl Hlth & Environm Res Lab, Midcontinent Ecol Div, Duluth, MN USA.
RP Vinson, MR (reprint author), US Geol Survey, Great Lakes Sci Ctr, Lake Super Biol Stn, 2800 Lake Shore Dr E, Ashland, WI 54806 USA.
EM mvinson@usgs.gov
NR 25
TC 10
Z9 10
U1 0
U2 21
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1064-1262
J9 REV FISH SCI
JI Rev. Fish. Sci.
PY 2011
VL 19
IS 2
BP 63
EP 73
AR PII 931551533
DI 10.1080/10641262.2010.536856
PG 11
WC Fisheries
SC Fisheries
GA 733OK
UT WOS:000288271900001
ER
PT S
AU Daughton, CG
AF Daughton, Christian G.
BE Whitacre, DM
TI Illicit Drugs: Contaminants in the Environment and Utility in Forensic
Epidemiology
SO REVIEWS OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, VOL 210
SE Reviews of Environmental Contamination and Toxicology
LA English
DT Review; Book Chapter
ID TANDEM MASS-SPECTROMETRY; SOLID-PHASE EXTRACTION; PERSONAL CARE
PRODUCTS; WASTE-WATER TREATMENT; SURFACE-WATER; UNITED-STATES;
TREATMENT-PLANT; STIMULATORY DRUGS; PAPER CURRENCY; SEWAGE-SLUDGE
C1 US EPA, Environm Chem Branch, Natl Exposure Res Lab, Las Vegas, NV 89119 USA.
RP Daughton, CG (reprint author), US EPA, Environm Chem Branch, Natl Exposure Res Lab, Las Vegas, NV 89119 USA.
EM daughton.christian@epa.gov
RI Umrani, Sumera/B-4532-2012;
OI Daughton, Christian/0000-0002-0302-7730
NR 183
TC 47
Z9 49
U1 1
U2 33
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
SN 0179-5953
BN 978-1-4419-7614-7
J9 REV ENVIRON CONTAM T
JI Rev. Environ. Contam. Toxicol.
PY 2011
VL 210
BP 59
EP 110
DI 10.1007/978-1-4419-7615-4_3
D2 10.1007/978-1-4419-7615-4
PG 52
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA BSP89
UT WOS:000285329800003
PM 21170703
ER
PT J
AU Brown, MA
Dworkin, M
AF Brown, Marilyn A.
Dworkin, Michael
BE Sovacool, BK
TI THE ENVIRONMENTAL DIMENSION OF ENERGY SECURITY
SO ROUTLEDGE HANDBOOK OF ENERGY SECURITY
SE Routledge International Handbooks
LA English
DT Article; Book Chapter
C1 [Brown, Marilyn A.] Georgia Inst Technol, Sch Publ Policy, Atlanta, GA 30332 USA.
[Dworkin, Michael] US EPA, Off Gen Counsel, Washington, DC USA.
RP Brown, MA (reprint author), Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA.
NR 47
TC 2
Z9 2
U1 0
U2 1
PU ROUTLEDGE
PI LONDON
PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND
BN 978-0-203-83460-2
J9 ROUT INT HANDB
PY 2011
BP 176
EP 190
PG 15
WC Environmental Studies; International Relations
SC Environmental Sciences & Ecology; International Relations
GA BXG97
UT WOS:000296099000009
ER
PT S
AU Jacobson, RB
Berkley, J
AF Jacobson, Robert B.
Berkley, Jim
BE Simon, A
Bennett, SJ
Castro, JM
TI Conceptualizing and Communicating Ecological River Restoration
SO STREAM RESTORATION IN DYNAMIC FLUVIAL SYSTEMS: SCIENTIFIC APPROACHES,
ANALYSES, AND TOOLS
SE Geophysical Monograph Series
LA English
DT Article; Book Chapter
ID LOWER MISSOURI RIVER; FLOW REGIME; MANAGEMENT; SCIENTISTS; BASIN;
REHABILITATION; CONSERVATION; ECOSYSTEMS; STRATEGIES; INTEGRITY
AB We present a general conceptual model for communicating aspects of river restoration and management. The model is generic and adaptable to most riverine settings, independent of size. The model has separate categories of natural and social-economic drivers, and management actions are envisioned as modifiers of naturally dynamic systems. The model includes a decision-making structure in which managers, stakeholders, and scientists interact to define management objectives and performance evaluation. The model depicts a stress to the riverine ecosystem as either (1) deviation in the regimes (flow, sediment, temperature, light, biogeochemical, and genetic) by altering the frequency, magnitude, duration, timing, or rate of change of the fluxes or (2) imposition of a hard structural constraint on channel form. Restoration is depicted as naturalization of those regimes or removal of the constraint. The model recognizes the importance of river history in conditioning future responses. Three hierarchical tiers of essential ecosystem characteristics (EECs) illustrate how management actions typically propagate through physical/chemical processes to habitat to biotic responses. Uncertainty and expense in modeling or measuring responses increase in moving from tiers 1 to 3. Social-economic characteristics are shown in a parallel structure that emphasizes the need to quantify trade-offs between ecological and social-economic systems. Performance measures for EECs are also hierarchical, showing that selection of measures depend on participants' willingness to accept uncertainty. The general form is of an adaptive management loop in which the performance measures are compared to reference conditions or success criteria and the information is fed back into the decision-making process.
C1 [Jacobson, Robert B.] US Geol Survey, Columbia, MO 65201 USA.
[Berkley, Jim] US EPA, Denver, CO USA.
RP Jacobson, RB (reprint author), US Geol Survey, Columbia, MO 65201 USA.
NR 63
TC 3
Z9 3
U1 2
U2 3
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 0065-8448
BN 978-1-118-66667-8; 978-0-87590-483-2
J9 GEOPHYS MONOGR SER
PY 2011
VL 194
BP 9
EP 27
DI 10.1029/2010GM000967
D2 10.1029/GM194
PG 19
WC Geosciences, Multidisciplinary; Water Resources
SC Geology; Water Resources
GA BA5PW
UT WOS:000336929500003
ER
PT J
AU Goldstein, BD
AF Goldstein, Bernard D.
GP Natl Res Council
TI Sustainability and the US EPA Summary
SO SUSTAINABILITY AND THE U.S. EPA
LA English
DT Editorial Material; Book Chapter
C1 US EPA, Comm Inc Sustainabil, Washington, DC 20460 USA.
RP Goldstein, BD (reprint author), US EPA, Comm Inc Sustainabil, Washington, DC 20460 USA.
NR 3
TC 1
Z9 1
U1 0
U2 2
PU NATL ACADEMIES PRESS
PI WASHINGTON
PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA
BN 978-0-309-21252-6
PY 2011
BP 1
EP 6
PG 6
WC Environmental Studies
SC Environmental Sciences & Ecology
GA BC7HU
UT WOS:000354890500002
ER
PT J
AU Goldstein, BD
AF Goldstein, Bernard D.
GP Natl Res Council
TI Sustainability and the US EPA Introduction
SO SUSTAINABILITY AND THE U.S. EPA
LA English
DT Editorial Material; Book Chapter
C1 US EPA, Comm Inc Sustainabil, Washington, DC 20460 USA.
RP Goldstein, BD (reprint author), US EPA, Comm Inc Sustainabil, Washington, DC 20460 USA.
NR 14
TC 0
Z9 0
U1 0
U2 0
PU NATL ACADEMIES PRESS
PI WASHINGTON
PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA
BN 978-0-309-21252-6
PY 2011
BP 7
EP 14
PG 8
WC Environmental Studies
SC Environmental Sciences & Ecology
GA BC7HU
UT WOS:000354890500003
ER
PT J
AU Goldstein, BD
AF Goldstein, Bernard D.
GP Natl Res Council
TI Sustainability and the US EPA Preface
SO SUSTAINABILITY AND THE U.S. EPA
LA English
DT Editorial Material; Book Chapter
C1 US EPA, Comm Inc Sustainabil, Washington, DC 20460 USA.
RP Goldstein, BD (reprint author), US EPA, Comm Inc Sustainabil, Washington, DC 20460 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATL ACADEMIES PRESS
PI WASHINGTON
PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA
BN 978-0-309-21252-6
PY 2011
BP VII
EP VIII
PG 2
WC Environmental Studies
SC Environmental Sciences & Ecology
GA BC7HU
UT WOS:000354890500001
ER
PT J
AU Goldstein, BD
AF Goldstein, Bernard D.
GP Natl Res Council
TI History of Sustainability
SO SUSTAINABILITY AND THE U.S. EPA
LA English
DT Article; Book Chapter
ID SCIENCE; POLICY
C1 US EPA, Comm Inc Sustainabil, Washington, DC 20460 USA.
RP Goldstein, BD (reprint author), US EPA, Comm Inc Sustainabil, Washington, DC 20460 USA.
NR 81
TC 0
Z9 0
U1 0
U2 0
PU NATL ACADEMIES PRESS
PI WASHINGTON
PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA
BN 978-0-309-21252-6
PY 2011
BP 15
EP 33
PG 19
WC Environmental Studies
SC Environmental Sciences & Ecology
GA BC7HU
UT WOS:000354890500004
ER
PT J
AU Goldstein, BD
AF Goldstein, Bernard D.
GP Natl Res Council
TI A Sustainability Framework for EPA
SO SUSTAINABILITY AND THE U.S. EPA
LA English
DT Article; Book Chapter
C1 US EPA, Comm Inc Sustainabil, Washington, DC 20460 USA.
RP Goldstein, BD (reprint author), US EPA, Comm Inc Sustainabil, Washington, DC 20460 USA.
NR 36
TC 0
Z9 0
U1 0
U2 0
PU NATL ACADEMIES PRESS
PI WASHINGTON
PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA
BN 978-0-309-21252-6
PY 2011
BP 35
EP 52
PG 18
WC Environmental Studies
SC Environmental Sciences & Ecology
GA BC7HU
UT WOS:000354890500005
ER
PT J
AU Goldstein, BD
AF Goldstein, Bernard D.
GP Natl Res Council
TI Sustainability Assessment and Management: Process, Tools, and Indicators
SO SUSTAINABILITY AND THE U.S. EPA
LA English
DT Article; Book Chapter
ID CLIMATE-CHANGE; BIOFUELS; ETHANOL; ENERGY; COSTS
C1 US EPA, Comm Inc Sustainabil, Washington, DC 20460 USA.
RP Goldstein, BD (reprint author), US EPA, Comm Inc Sustainabil, Washington, DC 20460 USA.
NR 68
TC 0
Z9 0
U1 0
U2 0
PU NATL ACADEMIES PRESS
PI WASHINGTON
PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA
BN 978-0-309-21252-6
PY 2011
BP 53
EP 77
PG 25
WC Environmental Studies
SC Environmental Sciences & Ecology
GA BC7HU
UT WOS:000354890500006
ER
PT J
AU Goldstein, BD
AF Goldstein, Bernard D.
GP Natl Res Council
TI How Risk Assessment and Risk Management Relate to the Sustainability
Framework
SO SUSTAINABILITY AND THE U.S. EPA
LA English
DT Article; Book Chapter
ID POLICY
C1 US EPA, Comm Inc Sustainabil, Washington, DC 20460 USA.
RP Goldstein, BD (reprint author), US EPA, Comm Inc Sustainabil, Washington, DC 20460 USA.
NR 21
TC 0
Z9 0
U1 0
U2 0
PU NATL ACADEMIES PRESS
PI WASHINGTON
PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA
BN 978-0-309-21252-6
PY 2011
BP 79
EP 91
PG 13
WC Environmental Studies
SC Environmental Sciences & Ecology
GA BC7HU
UT WOS:000354890500007
ER
PT J
AU Goldstein, BD
AF Goldstein, Bernard D.
GP Natl Res Council
TI Changing the Culture in EPA
SO SUSTAINABILITY AND THE U.S. EPA
LA English
DT Article; Book Chapter
ID SUSTAINABILITY; MANAGEMENT
C1 US EPA, Comm Inc Sustainabil, Washington, DC 20460 USA.
RP Goldstein, BD (reprint author), US EPA, Comm Inc Sustainabil, Washington, DC 20460 USA.
NR 37
TC 0
Z9 0
U1 0
U2 0
PU NATL ACADEMIES PRESS
PI WASHINGTON
PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA
BN 978-0-309-21252-6
PY 2011
BP 93
EP 110
PG 18
WC Environmental Studies
SC Environmental Sciences & Ecology
GA BC7HU
UT WOS:000354890500008
ER
PT J
AU Goldstein, BD
AF Goldstein, Bernard D.
GP Natl Res Council
TI Benefits of a Sustainability Approach at EPA
SO SUSTAINABILITY AND THE U.S. EPA
LA English
DT Article; Book Chapter
C1 US EPA, Comm Inc Sustainabil, Washington, DC 20460 USA.
RP Goldstein, BD (reprint author), US EPA, Comm Inc Sustainabil, Washington, DC 20460 USA.
NR 34
TC 0
Z9 0
U1 0
U2 0
PU NATL ACADEMIES PRESS
PI WASHINGTON
PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA
BN 978-0-309-21252-6
PY 2011
BP 111
EP 125
PG 15
WC Environmental Studies
SC Environmental Sciences & Ecology
GA BC7HU
UT WOS:000354890500009
ER
PT J
AU Goldstein, BD
AF Goldstein, Bernard D.
GP Natl Res Council
TI The Committee on Incorporating Sustainability in the US Environmental
Protection Agency
SO SUSTAINABILITY AND THE U.S. EPA
LA English
DT Article; Book Chapter
C1 US EPA, Comm Inc Sustainabil, Washington, DC 20460 USA.
RP Goldstein, BD (reprint author), US EPA, Comm Inc Sustainabil, Washington, DC 20460 USA.
NR 11
TC 0
Z9 0
U1 0
U2 0
PU NATL ACADEMIES PRESS
PI WASHINGTON
PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA
BN 978-0-309-21252-6
PY 2011
BP 127
EP 150
PG 24
WC Environmental Studies
SC Environmental Sciences & Ecology
GA BC7HU
UT WOS:000354890500010
ER
PT J
AU Williams, KA
Manley, DG
Pilgrim, EM
Von Dohlen, CD
Pitts, JP
AF Williams, Kevin A.
Manley, Donald G.
Pilgrim, Erik M.
Von Dohlen, Carol D.
Pitts, James P.
TI Multifaceted assessment of species validity in the Dasymutilla bioculata
species group (Hymenoptera: Mutillidae)
SO SYSTEMATIC ENTOMOLOGY
LA English
DT Article
ID ASHMEAD HYMENOPTERA; FOX HYMENOPTERA; DOMINICAN AMBER; VELVET ANTS;
ITS1; COCKERELL; SYNONYMY
AB This study examines the validity of the ten species and eight subspecies composing the Dasymutilla bioculata species group. Four lines of evidence are examined: morphological data derived from both sexes; behavioural data derived from the study of mating pairs; geographic distribution; and molecular data derived from the internal transcribed spacers 1 and 2 of the nuclear ribosomal RNA cistron (ITS1 and ITS2). Morphological studies reveal that none of the taxa in question can be consistently diagnosed by any synapomorphies or unique combinations of characters. Mating studies reveal that males of single nominal taxa are attracted to females of multiple nominal taxa, and that females of single nominal taxa attract multiple males. None of the nominal taxa are geographically isolated from the others. Genetic distances between these taxa are significantly lower than those seen in interspecific comparisons of other Dasymutilla species. Based on this evidence, we infer that the taxa in question share a recent common ancestor, and cannot be adequately differentiated using any of the available data sources. Therefore, employing the phylogenetic species concept, Dasymutilla bimaculata Manley & Pitts, Dasymutilla chiron chiron (Blake), Dasymutilla chiron ursula (Cresson), Dasymutilla creusa creusa (Cresson), Dasymutilla creusa bellona (Cresson), Dasymutilla lepeletierii (Fox), Dasymutilla medea (Cresson), Dasymutilla melanippe melanippe Mickel, Dasymutilla melanippe conformis Mickel, Dasymutilla praegrandis praegrandis Mickel, Dasymutilla praegrandis russata Mickel, Dasymutilla pyrrhus (Fox) and Dasymutilla sulcatulla Mickel must be considered junior synonyms of Dasymutilla bioculata (Cresson). We also discuss the identification of this species, as well as subspecific relationships and species-group implications.
C1 [Williams, Kevin A.; Von Dohlen, Carol D.; Pitts, James P.] Utah State Univ, Dept Biol, Logan, UT 84322 USA.
[Manley, Donald G.] Clemson Univ, Dept Entomol, Soils & Plant Sci Pee Dee Res & Educ Ctr, Florence, SC 29506 USA.
[Pilgrim, Erik M.] US EPA, Ecol Exposure Res Div, Cincinnati, OH 45268 USA.
RP Williams, KA (reprint author), Utah State Univ, Dept Biol, 5305 Old Main Hill, Logan, UT 84322 USA.
EM kevin.williams@usu.edu
FU Utah Agricultural Experiment Station, Utah State University, Logan, UT,
U.S.A.
FX We thank Justin Schmidt and James Zimmerman for valuable insight into
Dasymutilla taxonomy. We thank Joseph Wilson, Stuart Fullerton, Shaun L.
Kelly, Brian Baldwin, George Waldren, Travis Boud and Al Hook for
providing specimens for this project. We thank Ed Riley for pointing out
collecting sites in eastern Texas. We also thank Carrie Drake for help
with DNA extraction, PCR and DNA sequencing, and Nicole Boehme, Andrew
Ermer and Sarah Clark for voucher specimen curation. Finally, we thank
Lars Vilhelmsen and three anonymous reviewers for improving this
manuscript through the process of peer review. This research was
supported by the Utah Agricultural Experiment Station, Utah State
University, Logan, UT, U.S.A. Approved as journal paper no. 8203.
NR 37
TC 6
Z9 6
U1 1
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0307-6970
EI 1365-3113
J9 SYST ENTOMOL
JI Syst. Entomol.
PD JAN
PY 2011
VL 36
IS 1
BP 180
EP 191
DI 10.1111/j.1365-3113.2010.00555.x
PG 12
WC Evolutionary Biology; Entomology
SC Evolutionary Biology; Entomology
GA 703SV
UT WOS:000286002500013
ER
PT B
AU Miller, CA
AF Miller, C. Andrew
BE Hidy, GM
Brook, JR
Demerjian, KL
Molina, LT
Pennell, WT
Scheffe, RD
TI Source Emissions in Multipollutant Air Quality Management
SO TECHNICAL CHALLENGES OF MULTIPOLLUTANT AIR QUALITY MANAGEMENT
LA English
DT Article; Book Chapter
ID BALANCE RECEPTOR MODEL; MEXICO-CITY; ON-ROAD; PARTICULATE MATTER;
VEHICLE EMISSIONS; TRANSITION-METALS; METROPOLITAN-AREA; MASS;
POLLUTION; INJURY
C1 US EPA, Res Triangle Pk, NC 27711 USA.
RP Miller, CA (reprint author), US EPA, 109 TW Alexander Dr,Mail Code E305-02, Res Triangle Pk, NC 27711 USA.
EM miller.andy@epa.gov
NR 56
TC 1
Z9 1
U1 1
U2 2
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
BN 978-94-007-0303-2
PY 2011
BP 261
EP 298
DI 10.1007/978-94-007-0304-9_8
D2 10.1007/978-94-007-0304-9
PG 38
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA BWM39
UT WOS:000294234100008
ER
PT B
AU Seigneur, C
Dennis, R
AF Seigneur, Christian
Dennis, Robin
BE Hidy, GM
Brook, JR
Demerjian, KL
Molina, LT
Pennell, WT
Scheffe, RD
TI Atmospheric Modeling
SO TECHNICAL CHALLENGES OF MULTIPOLLUTANT AIR QUALITY MANAGEMENT
LA English
DT Article; Book Chapter
ID EASTERN UNITED-STATES; AIR-QUALITY MODELS; POSITIVE MATRIX
FACTORIZATION; SOURCE APPORTIONMENT; MEXICO-CITY; PARTICULATE MATTER;
DISPERSION MODEL; TRANSPORT MODEL; PERFORMANCE EVALUATION; UNCERTAINTY
ANALYSIS
C1 [Dennis, Robin] US EPA, Res Triangle Pk, NC 27711 USA.
[Seigneur, Christian] Univ Paris Est, F-77455 Marne La Vallee 2, France.
RP Dennis, R (reprint author), US EPA, 109 TW Alexander Dr,Mail Code E243-0l, Res Triangle Pk, NC 27711 USA.
EM seigneur@cerea.enpc.fr; dennis.robin@epa.gov
NR 94
TC 2
Z9 2
U1 1
U2 2
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
BN 978-94-007-0303-2
PY 2011
BP 299
EP 337
DI 10.1007/978-94-007-0304-9_9
D2 10.1007/978-94-007-0304-9
PG 39
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA BWM39
UT WOS:000294234100009
ER
PT B
AU Scheffe, RD
Brook, JR
Demerjian, KL
AF Scheffe, Richard D.
Brook, Jeffrey R.
Demerjian, Kenneth L.
BE Hidy, GM
Brook, JR
Demerjian, KL
Molina, LT
Pennell, WT
Scheffe, RD
TI Air Quality Measurements
SO TECHNICAL CHALLENGES OF MULTIPOLLUTANT AIR QUALITY MANAGEMENT
LA English
DT Article; Book Chapter
ID INDUCED FLUORESCENCE DETECTION; MATTER SUPERSITES PROGRAM; FINE
PARTICULATE MATTER; IN-SITU MEASUREMENTS; NITROGEN-DIOXIDE;
NORTH-AMERICA; MEXICO-CITY; GAS-PHASE; SCIENTIFIC FINDINGS; PERSONAL
EXPOSURES
C1 [Scheffe, Richard D.] US EPA, Res Triangle Pk, NC 27711 USA.
[Brook, Jeffrey R.] Environm Canada, Downsview, ON M3H 5T4, Canada.
[Demerjian, Kenneth L.] SUNY Albany, Atmospher Sci Res Ctr, CESTM, Albany, NY 12203 USA.
RP Scheffe, RD (reprint author), US EPA, 109 TW Alexander Dr,Mail Code C304-01, Res Triangle Pk, NC 27711 USA.
EM scheffe.rich@epa.gov; jeff.brook@ec.gc.ca; kld@asrc.cestm.albany.edu
NR 125
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
BN 978-94-007-0303-2
PY 2011
BP 339
EP 393
DI 10.1007/978-94-007-0304-9_10
D2 10.1007/978-94-007-0304-9
PG 55
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA BWM39
UT WOS:000294234100010
ER
PT J
AU Bolon, B
Funk, KA
Sills, RC
AF Bolon, Brad
Funk, Kathleen A.
Sills, Robert C.
TI Introduction and Commentary: "Toxicologic Neuropathology"-and a Whole
Lot More! The 2010 Joint STP/IFSTP International Symposium on
Toxicologic Pathology
SO TOXICOLOGIC PATHOLOGY
LA English
DT Editorial Material
ID NEUROTOXICITY
C1 [Bolon, Brad] GEMpath Inc, Longmont, CO 80503 USA.
[Funk, Kathleen A.] Expt Pathol Labs Inc, Sterling, VA USA.
[Sills, Robert C.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
RP Bolon, B (reprint author), GEMpath Inc, 2867 Humboldt Cir, Longmont, CO 80503 USA.
EM brad@gempath.net
NR 9
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0192-6233
EI 1533-1601
J9 TOXICOL PATHOL
JI Toxicol. Pathol.
PD JAN
PY 2011
VL 39
IS 1
BP 11
EP 14
DI 10.1177/0192623310385144
PG 4
WC Pathology; Toxicology
SC Pathology; Toxicology
GA 800QU
UT WOS:000293379600001
PM 21078919
ER
PT J
AU Moser, VC
AF Moser, Virginia C.
TI Functional Assays for Neurotoxicity Testing
SO TOXICOLOGIC PATHOLOGY
LA English
DT Article
DE neurotoxicity; behavior; function; functional observational battery;
Irwin screen; cognition
ID CARBON-DISULFIDE NEUROTOXICITY; NEUROBEHAVIORAL SCREENING BATTERY;
PERIPHERAL-NERVE REGENERATION; INDUCED DELAYED NEUROPATHY; OBSERVATIONAL
BATTERY; ACRYLAMIDE NEUROPATHY; BEHAVIORAL-TESTS; TRIMETHYLTIN
COMPOUNDS; LABORATORY RODENTS; CHRONIC TOXICITY
AB Neurobehavioral and pathological evaluations of the nervous system are complementary components of basic research and toxicity testing of pharmaceutical and environmental chemicals. While neuropathological assessments provide insight as to cellular changes in neurons, behavioral and physiological methods evaluate the functional consequences of disruption of neuronal communications. The underlying causes of certain behavioral alterations may be understood, but many do not have known direct associations with specific brain pathologies. In some cases, however, rapidly expanding mouse models (transgenic, knock-out) are providing considerable information on behavioral phenotypes of altered pathology. Behavior represents the integrated sum of activities mediated by the nervous system, and functional tests used for neurotoxicity testing tap different behavioral repertoires. These tests have an advantage over pathologic measures in that they permit repeated evaluation of a single animal over time to determine the onset, progression, duration, and reversibility of a neurotoxic injury. Functional assays range from a screening-level battery of tests to refined procedures to tap specific forms of learning and/or memory. This article reviews common procedures for behavioral toxicity testing and provides examples of chemical-specific neurobehavioral-pathological correlations in order to inform interpretation and integration of neuropathological and behavioral outcomes.
C1 [Moser, Virginia C.] US EPA, Neurotox Branch, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Res Triangle Pk, NC 27711 USA.
RP Moser, VC (reprint author), US EPA, Tox Assessment Div MD B105 04, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM moser.ginger@epa.gov
NR 142
TC 32
Z9 35
U1 1
U2 14
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0192-6233
J9 TOXICOL PATHOL
JI Toxicol. Pathol.
PD JAN
PY 2011
VL 39
IS 1
BP 36
EP 45
DI 10.1177/0192623310385255
PG 10
WC Pathology; Toxicology
SC Pathology; Toxicology
GA 800QU
UT WOS:000293379600005
PM 21075917
ER
PT J
AU Hale, SL
Andrews-Jones, L
Jordan, WH
Jortner, BS
Boyce, RW
Boyce, JT
Switzer, RC
Butt, MT
Garman, RH
Jensen, K
Krinke, G
Little, PB
AF Hale, Sarah L.
Andrews-Jones, Lydia
Jordan, William H.
Jortner, Bernard S.
Boyce, Rogely W.
Boyce, John T.
Switzer, Robert C., III
Butt, Mark T.
Garman, Robert H.
Jensen, Karl
Krinke, Georg
Little, Peter B.
TI Modern Pathology Methods for Neural Investigations
SO TOXICOLOGIC PATHOLOGY
LA English
DT Article
DE nervous system sampling; neurohistology; stereology
ID NERVOUS-SYSTEM; RAPID METHOD; RATS; NEUROPATHOLOGY; NEUROTOXICITY;
DEGENERATION; INHALATION
AB This session at the 2010 joint symposium of the Society of Toxicologic Pathology (STP) and the International Federation of Societies of Toxicologic Pathologists (IFSTP) explored modern neuropathology methods for assessing the neurotoxicologic potential of xenobiotics. Conventional techniques to optimally prepare and evaluate the central and peripheral neural tissues while minimizing artifact were reviewed, and optimal schemes were set forth for evaluation of the nervous system during both routine (i.e., general toxicity) studies and enhanced (i.e., specialized neurotoxicity) studies. Stereology was introduced as the most appropriate means of examining the possible impact of toxicants on neural cell numbers. A focused discussion on brain sampling took place among a panel of expert neuroscientists (anatomists and pathologists) and the audience regarding the proper balance between sufficient sampling and cost-and time-effectiveness of the analysis. No consensus was reached on section orientation (coronal sections of both sides vs. a parasagittal longitudinal section with several unilateral hemisections from the contralateral side), but most panelists favored sampling at least 8 sections (or approximately double to triple the current complement) in routine toxicity studies.
C1 [Andrews-Jones, Lydia] Allergan, Drug Safety Evaluat, Irvine, CA 92612 USA.
[Hale, Sarah L.; Krinke, Georg] Covance Labs Inc, Vienna, VA USA.
[Jordan, William H.] Vet Path Serv Inc, Mason, OH USA.
[Jortner, Bernard S.] Virginia Polytech Inst & State Univ, Virginia Maryland Reg Coll Vet Med, Blacksburg, VA 24061 USA.
[Boyce, Rogely W.; Boyce, John T.] WIL Res Labs, Ashland, OH USA.
[Switzer, Robert C., III] NeuroScience Associates, Knoxville, TN USA.
[Butt, Mark T.] Tox Path Specialists LLC, Walkersville, MD USA.
[Garman, Robert H.] Consultants Vet Pathol Inc, Murrysville, PA USA.
[Jensen, Karl] US EPA, Res Triangle Pk, NC 27711 USA.
PATHEV, CH-4402 Frenkendorf, Switzerland.
[Little, Peter B.] Charles River Labs PAI, Durham, NC USA.
RP Andrews-Jones, L (reprint author), Allergan, Drug Safety Evaluat, 2525 Dupont Dr,Mailstop RD2-2C, Irvine, CA 92612 USA.
EM andrews-jones_lydia@allergan.com
NR 30
TC 6
Z9 6
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0192-6233
EI 1533-1601
J9 TOXICOL PATHOL
JI Toxicol. Pathol.
PD JAN
PY 2011
VL 39
IS 1
BP 52
EP 57
DI 10.1177/0192623310394213
PG 6
WC Pathology; Toxicology
SC Pathology; Toxicology
GA 800QU
UT WOS:000293379600007
PM 21212254
ER
PT J
AU Bolon, B
Garman, RH
Gundersen, HJG
Johnson, GA
Kaufmann, W
Krinke, G
Little, PB
Makris, SL
Mellon, RD
Sulik, KK
Jensen, K
AF Bolon, Brad
Garman, Robert H.
Gundersen, Hans Jorgen G.
Johnson, G. Allan
Kaufmann, Wolfgang
Krinke, Georg
Little, Peter B.
Makris, Susan L.
Mellon, R. Daniel
Sulik, Kathleen K.
Jensen, Karl
TI Continuing Education Course #3: Current Practices and Future Trends in
Neuropathology Assessment for Developmental Neurotoxicity Testing
SO TOXICOLOGIC PATHOLOGY
LA English
DT Article
DE developmental neurotoxicity; neuropathology; risk assessment
ID MAGNETIC-RESONANCE MICROSCOPY; INDUCED BRAIN ABNORMALITIES; RAT-BRAIN;
ACUTE INSULT; EXPOSURE; SIZE
AB The continuing education course on Developmental Neurotoxicity Testing (DNT) was designed to communicate current practices for DNT neuropathology, describe promising innovations in quantitative analysis and noninvasive imaging, and facilitate a discussion among experienced neuropathologists and regulatory scientists regarding suitable DNT practices. Conventional DNT neuropathology endpoints are qualitative histopathology and morphometric endpoints of particularly vulnerable sites (e. g., cerebral, cerebellar, or hippocampal thickness). Novel imaging and stereology measurements hold promise for automated analysis of factors that cannot be effectively examined in routinely processed specimens (e. g., cell numbers, fiber tract integrity). The panel recommended that dedicated DNT neuropathology data sets be acquired on a minimum of 8 sections (for qualitative assessment) or 3 sections (for quantitative linear and stereological analyses) using a small battery of stains to examine neurons and myelin. Where guidelines permit discretion, immersion fixation is acceptable for younger animals (postnatal day 22 or earlier), and peripheral nerves may be embedded in paraffin. Frequent concerns regarding DNT data sets include false-negative outcomes due to processing difficulties (e. g., lack of concordance among sections from different animals) and insensitive analytical endpoints (e. g., qualitative evaluation) as well as false-positive results arising from overinterpretation or misreading by inexperienced pathologists.
C1 [Jensen, Karl] US EPA, NHEERL, ORD, Res Triangle Pk, NC 27711 USA.
[Bolon, Brad] GEMpath Inc, Longmont, CO USA.
[Garman, Robert H.] Consultants Vet Pathol, Murrysville, PA USA.
[Gundersen, Hans Jorgen G.] Univ Aarhus, DK-8000 Aarhus, Denmark.
[Johnson, G. Allan] Duke Univ, Durham, NC USA.
[Kaufmann, Wolfgang] BASF, Ludwigshafen, Germany.
[Little, Peter B.] Charles River Labs Inc, Durham, NC USA.
[Makris, Susan L.] US EPA, Washington, DC 20460 USA.
[Mellon, R. Daniel] US FDA, Silver Spring, MD USA.
[Sulik, Kathleen K.] Univ N Carolina, Chapel Hill, NC USA.
RP Jensen, K (reprint author), US EPA, NHEERL, ORD, Mail Drop B105-06, Res Triangle Pk, NC 27711 USA.
EM jensen.karl@epa.gov
OI Johnson, G.Allan/0000-0002-7606-5447
FU NCI NIH HHS [U24 CA092656]; NCRR NIH HHS [P41 RR005959]
NR 32
TC 8
Z9 8
U1 1
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0192-6233
J9 TOXICOL PATHOL
JI Toxicol. Pathol.
PD JAN
PY 2011
VL 39
IS 1
BP 289
EP 293
DI 10.1177/0192623310386247
PG 5
WC Pathology; Toxicology
SC Pathology; Toxicology
GA 800QU
UT WOS:000293379600032
PM 21075916
ER
PT J
AU Pilli, S
Bhunia, P
Yan, S
LeBlanc, RJ
Tyagi, RD
Surampalli, RY
AF Pilli, Sridhar
Bhunia, Puspendu
Yan, Song
LeBlanc, R. J.
Tyagi, R. D.
Surampalli, R. Y.
TI Ultrasonic pretreatment of sludge: A review
SO ULTRASONICS SONOCHEMISTRY
LA English
DT Review
DE Anaerobic digestion; Biological wastewater treatment; Cavitation; Waste
activated sludge; Ultrasonication
ID WASTE-ACTIVATED-SLUDGE; ENHANCED ANAEROBIC-DIGESTION; SEWAGE-SLUDGE;
CELL DISRUPTION; EXTRACELLULAR POLYMERS; BIOLOGICAL SLUDGE; SONICATED
SLUDGE; BATCH REACTOR; KINETIC-MODEL; DISINTEGRATION
AB Ultrasonication is an emerging and very effective mechanical pretreatment method to enhance the biodegradability of the sludge, and it would be very useful to all wastewater treatment plants in treating and disposing sewage sludge. Ultrasonication enhances the sludge digestibility by disrupting the physical, chemical and biological properties of the sludge. The degree of disintegration depends on the sonication parameters and also on sludge characteristics, therefore the evaluation of the optimum parameters varies with the type of sonicater and sludge to be treated. The full-scale installations of ultrasonication have demonstrated that there is 50% increase in the biogas generation, and in addition evaluation of energy balance showed that the average ratio of the net energy gain to electric consumed by the ultrasound device is 2.5. This review article summarizes the benefits of ultrasonication of sludge, the effect of sonication parameters, impact of sludge characteristics on sludge disintegration, and thereby the increase in biogas production in anaerobic digester. Due to uncertainty in the unit representation by many researchers and nonavailability of the data, comparison of these results is complicated. Comparison of ultrasonication with other pretreatment options is necessary to evaluate the best economical and environmental pretreatment technology for sludge treatment and disposal. The optimum parameters for the ultrasonication vary with sludge characteristics. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Pilli, Sridhar; Yan, Song; Tyagi, R. D.] INRS Eau, Quebec City, PQ G1K 9A9, Canada.
[Bhunia, Puspendu] Indian Inst Technol, Dept Civil Engn, Bhubaneswar 751013, Orissa, India.
[LeBlanc, R. J.] GMSC, Riverview, NB E1B 1S5, Canada.
[Surampalli, R. Y.] US EPA, Kansas City, KS 66117 USA.
RP Tyagi, RD (reprint author), INRS Eau, 490 Rue Couronne, Quebec City, PQ G1K 9A9, Canada.
EM tyagi@ete.inrs.ca
FU Natural Sciences and Engineering Research Council of Canada (NSERC),
Canada Research Chair [A4984]
FX The authors are sincerely thankful to the Natural Sciences and
Engineering Research Council of Canada (NSERC) (Grants A4984, Canada
Research Chair) for financial support. The views or opinions expressed
in this article are those of the authors and should not be construed as
opinions of USEPA.
NR 115
TC 205
Z9 225
U1 9
U2 201
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1350-4177
J9 ULTRASON SONOCHEM
JI Ultrason. Sonochem.
PD JAN
PY 2011
VL 18
IS 1
BP 1
EP 18
DI 10.1016/j.ultsonch.2010.02.014
PG 18
WC Acoustics; Chemistry, Multidisciplinary
SC Acoustics; Chemistry
GA 662ZQ
UT WOS:000282853200001
PM 20471901
ER
PT J
AU Selvakumar, A
Tafuri, AN
Morrison, R
Sterling, R
AF Selvakumar, Ariamalar
Tafuri, Anthony N.
Morrison, Robert
Sterling, Raymond
TI State of technology for renewal of sewer force mains
SO URBAN WATER JOURNAL
LA English
DT Article
DE renewal; force main; rehabilitation; cured-in place; replacement;
trenchless technologies
AB This paper presents the results of a review of the state of technology for renewal of force mains. Force mains are critical components of many sewer collection systems with significant environmental and cost consequences for failure. The review identified several needs, including the need for rational and common design approaches for rehabilitation systems, quality assurance/quality control procedures, and better practices for operation and maintenance. The difficulty in assessing the condition of sewer force mains, leaving many owners with questions about the integrity of their systems, and the limited amount of technologies available for renewing a deteriorated main, has limited the amount of renewal work in the past. Most of the renewal activity has involved complete replacement of the force main. As the nation's force mains age further, greater emphasis must be placed on finding cost-effective ways to renew these critical assets. Fortunately, new products and technologies are now emerging for condition assessment, as well as rehabilitation. Some newer methods developed for gravity sewers and water distribution systems are being adapted for use in force main rehabilitation but design and performance data gaps remain to be filled.
C1 [Selvakumar, Ariamalar; Tafuri, Anthony N.] US EPA, Natl Risk Management Res Lab, Urban Watershed Management Branch, Water Supply & Water Resources Div, Edison, NJ USA.
[Morrison, Robert] Jason Consultants, Columbus, OH USA.
[Sterling, Raymond] Louisiana Tech Univ, Ruston, LA 71270 USA.
RP Selvakumar, A (reprint author), US EPA, Natl Risk Management Res Lab, Urban Watershed Management Branch, Water Supply & Water Resources Div, Edison, NJ USA.
EM selvakumar.ariamalar@epa.gov
OI Sterling, Raymond/0000-0003-0587-9459
FU US Environmental Protection Agency, through its Office of Research and
Development
FX The US Environmental Protection Agency, through its Office of Research
and Development, funded and managed, or partially funded and
collaborated in, the research described herein. It has been subjected to
the Agency's peer and administrative review and has been approved for
external publication. Any opinions expressed in this paper are those of
the author(s) and do not necessarily reflect the views of the Agency,
therefore, no official endorsement should be inferred. Any mention of
trade names or commercial products does not constitute endorsement or
recommendation for use.
NR 67
TC 2
Z9 2
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1573-062X
J9 URBAN WATER J
JI Urban Water J.
PY 2011
VL 8
IS 5
BP 279
EP 292
DI 10.1080/1573062X.2011.598171
PG 14
WC Water Resources
SC Water Resources
GA 885NI
UT WOS:000299785300002
ER
PT J
AU Butler, BA
AF Butler, Barbara A.
TI Effect of imposed anaerobic conditions on metals release from acid-mine
drainage contaminated streambed sediments
SO WATER RESEARCH
LA English
DT Article
DE Iron oxyhydroxides; Manganese oxyhydroxides; Metal sulfides; Remediation
ID SURFACE-PROPERTIES; ORGANIC-MATTER; ADSORPTION; IRON; SCHWERTMANNITE;
SULFATE; OXIDES; GOETHITE; ELEMENTS; WATERS
AB Remediation of streams influenced by mine-drainage may require removal and burial of metal-containing bed sediments. Burial of aerobic sediments into an anaerobic environment may release metals, such as through reductive dissolution of metal oxyhydroxides. Mining-impacted aerobic streambed sediments collected from North Fork Clear Creek, Colorado were held under anaerobic conditions for four months. Eh, pH, and concentrations of Cd, Cu, Fe, Mn, and Zn (filtered at 1.5 mu m, 0.45 mu m, and 0.2 mu m), sulfate, and dissolved organic carbon (DOC) were monitored in stream water/sediment slurries. Two sediment size fractions were examined (2 mm-63 mu m and <63 mu m). Sequential extractions evaluated the mineral phase with which metals were associated in the aerobic sediment. Released Cu was re-sequestered within 5 weeks, while Fe and Mn still were present at 16 weeks. Mn concentration was lower than in the initial stream water at and beyond 14 weeks for the smaller sized sediment. Cd was not released from either sediment size fraction. Zn was released at early times, but concentrations never exceeded those present in the initial stream water and all was re-sequestered over time. The greatest concentrations of Cu, Fe, Mn, and Zn were associated with the Fe/Mn reducible fraction. Sulfate and Fe were strongly correlated (r = 0.90), seeming to indicate anaerobic dissolution of iron oxy-hydroxy-sulfate minerals. DOC and sulfate were strongly correlated (r = 0.81), with iron having a moderately strong correlation with DOG (r = 0.71). Overall concentrations of DOC, sulfate, Cu, Fe, and Zn and pH were significantly higher ( p < 0.05) in the water overlying the small sized sediment samples, while the concentrations of Mn released from the larger sized sediment samples were greater. Published by Elsevier Ltd.
C1 US EPA, Off Res & Dev, Natl Risk Management Res Lab, Land Remediat & Pollut Control Div, Cincinnati, OH 45268 USA.
RP Butler, BA (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Land Remediat & Pollut Control Div, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM Butler.Barbara@epa.gov
FU U.S. EPA, through its Office of Research and Development
FX The U.S. EPA, through its Office of Research and Development, funded the
research described in this manuscript. It has been administratively
reviewed and approved for publishing. Citations of product, company, or
trade names do not constitute endorsement by the U.S. EPA and are
provided only for the purpose of better describing information in this
manuscript.
NR 33
TC 6
Z9 6
U1 1
U2 22
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0043-1354
J9 WATER RES
JI Water Res.
PD JAN
PY 2011
VL 45
IS 1
BP 328
EP 336
DI 10.1016/j.watres.2010.07.077
PG 9
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA 704BY
UT WOS:000286027300031
PM 20709348
ER
PT J
AU Gronewold, AD
Myers, L
Swall, JL
Noble, RT
AF Gronewold, Andrew D.
Myers, Luke
Swall, Jenise L.
Noble, Rachel T.
TI Addressing uncertainty in fecal indicator bacteria dark inactivation
rates
SO WATER RESEARCH
LA English
DT Article
DE Water quality modeling; Fecal contamination; Bayesian; MPN; Decay rate
ID SOUTHERN BRITTANY FRANCE; PROBABLE NUMBER METHOD; NEUSE RIVER ESTUARY;
SERIAL DILUTIONS; VILAINE BAY; WATER; MPN; TRANSPORT; COLIFORM; DENSITY
AB Assessing the potential threat of fecal contamination in surface water often depends on model forecasts which assume that fecal indicator bacteria (FIB, a proxy for the concentration of pathogens found in fecal contamination from warm-blooded animals) are lost or removed from the water column at a certain rate (often referred to as an "inactivation" rate). In efforts to reduce human health risks in these water bodies, regulators enforce limits on easily-measured FIB concentrations, commonly reported as most probable number (MPN) and colony forming unit (CFU) values. Accurate assessment of the potential threat of fecal contamination, therefore, depends on propagating uncertainty surrounding "true" FIB concentrations into MPN and CFU values, inactivation rates, model forecasts, and management decisions. Here, we explore how empirical relationships between FIB inactivation rates and extrinsic factors might vary depending on how uncertainty in MPN values is expressed. Using water samples collected from the Neuse River Estuary (NRE) in eastern North Carolina, we compare Escherichia coli (EC) and Enterococcus (ENT) dark inactivation rates derived from two statistical models of first-order loss; a conventional model employing ordinary least-squares (OLS) regression with MPN values, and a novel Bayesian model utilizing the pattern of positive wells in an IDEXX Quanti-Tray (R)/2000 test. While our results suggest that EC dark inactivation rates tend to decrease as initial EC concentrations decrease and that ENT dark inactivation rates are relatively consistent across different ENT concentrations, we find these relationships depend upon model selection and model calibration procedures. We also find that our proposed Bayesian model provides a more defensible approach to quantifying uncertainty in microbiological assessments of water quality than the conventional MPN-based model, and that our proposed model represents a new strategy for developing robust relationships between environmental factors and FIB inactivation rates, and for reducing uncertainty in water resource management decisions. Published by Elsevier Ltd.
C1 [Gronewold, Andrew D.] NOAA, Great Lakes Environm Res Lab, Ann Arbor, MI 48108 USA.
[Swall, Jenise L.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Myers, Luke; Noble, Rachel T.] Univ N Carolina, Inst Marine Sci, Morehead City, NC 28557 USA.
RP Gronewold, AD (reprint author), NOAA, Great Lakes Environm Res Lab, Ann Arbor, MI 48108 USA.
EM drew.gronewold@noaa.gov
OI Swall, Jenise/0000-0001-8728-5771; Gronewold, Andrew/0000-0002-3576-2529
FU North Carolina Division of Water Quality [EW05049]; United States
Environmental Protection Agency through Office of Research and
Development
FX This study was partially funded by the North Carolina Division of Water
Quality (Contract No. EW05049). In addition, the United States
Environmental Protection Agency, through its Office of Research and
Development, partially funded and collaborated in the research described
here. It has been subjected to Agency review and approved for
publication. This paper is GLERL contribution number 1573. The authors
thank Jim Wickham, Ibrahim Alameddine, James Christian, and two
anonymous reviewers for their comments on the manuscript.
NR 55
TC 10
Z9 10
U1 2
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0043-1354
J9 WATER RES
JI Water Res.
PD JAN
PY 2011
VL 45
IS 2
BP 652
EP 664
DI 10.1016/j.watres.2010.08.029
PG 13
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA 714EO
UT WOS:000286790500024
PM 20843534
ER
PT J
AU Besner, MC
Prevost, M
Regli, S
AF Besner, Marie-Claude
Prevost, Michele
Regli, Stig
TI Assessing the public health risk of microbial intrusion events in
distribution systems: Conceptual model, available data, and challenges
SO WATER RESEARCH
LA English
DT Review
DE Intrusion; Pressure; Drinking water distribution system; Microbial
contamination; Transient analysis; Public health risk
ID WATER DISTRIBUTION-SYSTEMS; ESCHERICHIA-COLI O157-H7; LOW-PRESSURE
EVENTS; DRINKING-WATER; HYDRAULIC TRANSIENTS; GASTROINTESTINAL ILLNESS;
PATHOGEN INTRUSION; CONTROLLED-TRIAL; DOSE-RESPONSE; TAP WATER
AB Low and negative pressure events in drinking water distribution systems have the potential to result in intrusion of pathogenic microorganisms if an external source of contamination is present (e.g., nearby leaking sewer main) and there is a pathway for contaminant entry (e.g., leaks in drinking water main). While the public health risk associated with such events is not well understood, quantitative microbial risk assessment can be used to estimate such risk. A conceptual model is provided and the state of knowledge, current assumptions, and challenges associated with the conceptual model parameters are presented. This review provides a characterization of the causes, magnitudes, durations and frequencies of low/negative pressure events; pathways for pathogen entry; pathogen occurrence in external sources of contamination; volumes of water that may enter through the different pathways; fate and transport of pathogens from the pathways of entry to customer taps; pathogen exposure to populations consuming the drinking water; and risk associated with pathogen exposure. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Besner, Marie-Claude; Regli, Stig] US EPA, Off Ground Water & Drinking Water, Washington, DC 20460 USA.
[Prevost, Michele] Ecole Polytech, NSERC Ind Chair Drinking Water Civil Geol & Min E, Montreal, PQ H3C 3A7, Canada.
RP Besner, MC (reprint author), US EPA, Off Ground Water & Drinking Water, Mail Code 4607M,1200 Pennsylvania Ave, Washington, DC 20460 USA.
EM mcbesner@polymtl.ca; michele.prevost@polymtl.ca;
Regli.Stig@epamail.epa.gov
FU Natural Sciences and Engineering Research Council of Canada; U.S.
Department of Energy; U.S. Environmental Protection Agency
FX This research was supported in part by a post-doctoral fellowship from
the Natural Sciences and Engineering Research Council of Canada and by
an appointment to the Research Participation Program at the Office of
Ground Water and Drinking Water administered by the Oak Ridge Institute
for Science and Education through an interagency agreement between the
U.S. Department of Energy and the U.S. Environmental Protection Agency.
NR 105
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U1 3
U2 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0043-1354
J9 WATER RES
JI Water Res.
PD JAN
PY 2011
VL 45
IS 3
BP 961
EP 979
DI 10.1016/j.watres.2010.10.035
PG 19
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA 717NK
UT WOS:000287054500001
PM 21106216
ER
PT J
AU Van Ginkel, SW
Tang, Y
Rittmann, BE
AF Van Ginkel, Steven W.
Tang, Youneng
Rittmann, Bruce E.
TI Impact of precipitation on the treatment of real ion-exchange brine
using the H-2-based membrane biofilm reactor
SO WATER SCIENCE AND TECHNOLOGY
LA English
DT Article
DE ion-exchange brine; MBfR; nitrate; salinity; solubility
ID BIOLOGICAL TREATMENT; PERCHLORATE; NITRATE; DENITRIFICATION; REDUCTION;
WATER
AB The H-2-based membrane biofilm reactor (MBfR) was used to remove nitrate and perchlorate from real ion-exchange brine at two different salinities (30- and 50-g/L NaCl). Base production from nitrate reduction to N-2 gas caused the pH to increase, and this exacerbated precipitation of calcium and magnesium carbonates onto the MBfR fibers. The precipitates lowered the H-2 flux to the biofilm and caused a deterioration of denitrification performance that could be reversed by mild citric-acid washing. The addition of acid seems to be the only mechanism to avoid serious precipitation, membrane fouling, and non-optimal pH for denitrification.
C1 [Van Ginkel, Steven W.; Tang, Youneng; Rittmann, Bruce E.] Arizona State Univ, Biodesign Inst, Ctr Environm Biotechnol, Tempe, AZ 85287 USA.
[Van Ginkel, Steven W.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Van Ginkel, SW (reprint author), Arizona State Univ, Biodesign Inst, Ctr Environm Biotechnol, POB 875701, Tempe, AZ 85287 USA.
EM steppen@asu.edu; youneng.tang@asu.edu; rittmann@asu.edu
FU APTwater (Long Beach, CA)
FX The authors thank Geno S. Lehman and Mohammad Badruzzaman of
Montgomery-Watson-Harza for operating the IX process and supplying the
brine. We also thank David A. Vaccari for help with the speciation of
calcium and magnesium. Any opinions expressed in this paper are those of
the author(s) and do not, necessarily, reflect the official position and
policies of the U. S. EPA. Any mention of the products or trade names
does not constitute recommendation for use by the U. S. EPA. The authors
also thank APTwater (Long Beach, CA) for their insights and partial
financial support for this project.
NR 20
TC 9
Z9 9
U1 3
U2 24
PU IWA PUBLISHING
PI LONDON
PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND
SN 0273-1223
J9 WATER SCI TECHNOL
JI Water Sci. Technol.
PY 2011
VL 63
IS 7
BP 1453
EP 1458
DI 10.2166/wst.2011.330
PG 6
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA 759CK
UT WOS:000290217600018
PM 21508550
ER
PT J
AU Cole, CA
Kentula, ME
AF Cole, Charles A.
Kentula, Mary E.
BE LePage, BA
TI Monitoring and Assessment-What to Measure ... and Why
SO WETLANDS: INTEGRATING MULTIDISCIPLINARY CONCEPTS
LA English
DT Article; Book Chapter
ID WETLAND RESTORATION; WATER WETLANDS; HYDROLOGY; INDICATORS;
CLASSIFICATION; VEGETATION; COMMUNITIES; MITIGATION; STRATEGIES;
FREQUENCY
AB It is often difficult to know what to measure when conducting a wetland assessment. There are a wide variety of variables to consider across the three main parameters-water, vegetation, and soils. To complicate things even further, the aspect of time and space must be considered if you wish to be able to make sense of your assessment. We present a discussion of water, vegetation, and soils and then give our best judgment of which variables to measure for each, and why some might be more useful than others. The merits and problems with gathering data from single visits versus multiple visits are discussed, as well as the level of expertise needed in some instances for certain variables to be useful. We do not discuss assessment and inventory methods as these will follow once you chose your assessment variables most relevant to your goals.
C1 [Cole, Charles A.] Penn State Univ, Dept Landscape Architecture, University Pk, PA 16802 USA.
[Kentula, Mary E.] US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA.
RP Cole, CA (reprint author), Penn State Univ, Dept Landscape Architecture, 121 Stuckeman Family Bldg, University Pk, PA 16802 USA.
EM cac13@psu.edu; kentula.mary@epa.gov
NR 61
TC 3
Z9 3
U1 1
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-94-007-0550-0
PY 2011
BP 137
EP 152
DI 10.1007/978-94-007-0551-7_8
D2 10.1007/978-94-007-0551-7
PG 16
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA BDF35
UT WOS:000313004700009
ER
PT J
AU Robertson, M
Hough, P
AF Robertson, Morgan
Hough, Palmer
BE LePage, BA
TI Wetlands Regulation: The Case of Mitigation Under Section 404 of the
Clean Water Act
SO WETLANDS: INTEGRATING MULTIDISCIPLINARY CONCEPTS
LA English
DT Article; Book Chapter
AB The requirement to mitigate impacts to wetlands and streams is a frequently-misunderstood policy with a long and complicated history. We narrate the history of mitigation since the inception of the Clean Water Act Section 404 permit program in 1972, through struggles between the United States Environmental Protection Agency and the United States Army Corps of Engineers (ACOE), through the emerging importance of wetland conservation on the American political landscape, and through the rise of market-based approaches to environmental policy. Mitigation, as it is understood today, was not initially foreseen as a component of the Section 404 permitting program, but was adapted from 1978 regulations issued by the Council on Environmental Quality as a way of replacing the functions of filled wetlands where permit denials were unlikely. The Environmental Protection Agency (USEPA) and the ACOE agreed in 1990 to define mitigation as the three steps of avoidance, minimization, and compensation, principles which must be applied to permit decisions in the form of the environmental criteria in USEPA's 404(b)(1) Guidelines. Through the 1980s and 1990s, the compensation component of mitigation has become nearly the sole focus of mitigation policy development, and has been the subject of numerous guidances and memoranda since 1990. Avoidance and minimization have received far less policy attention, and this lack of policy development may represent a missed opportunity to implement effective wetland conservation.
C1 [Robertson, Morgan] Univ Kentucky, Dept Geog, Lexington, KY 40506 USA.
[Hough, Palmer] US EPA, Off Water, Wetlands Div, Washington, DC 20460 USA.
RP Robertson, M (reprint author), Univ Kentucky, Dept Geog, 1457 Patterson Off Tower, Lexington, KY 40506 USA.
EM mmrobertson@uky.edu; hough.palmer@epa.gov
NR 43
TC 1
Z9 1
U1 1
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-94-007-0550-0
PY 2011
BP 171
EP 187
DI 10.1007/978-94-007-0551-7_10
D2 10.1007/978-94-007-0551-7
PG 17
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA BDF35
UT WOS:000313004700011
ER
PT J
AU Latimer, JS
Rego, SA
AF Latimer, James S.
Rego, Steven A.
TI Empirical relationship between eelgrass extent and predicted
watershed-derived nitrogen loading for shallow New England estuaries
SO ESTUARINE COASTAL AND SHELF SCIENCE
LA English
DT Article
DE New England; eutrophication; estuary; watershed nitrogen; eelgrass;
Zostera marina
ID SUBMERGED AQUATIC VEGETATION; ZOSTERA-MARINA; WAQUOIT BAY; SEAGRASS
ECOSYSTEMS; COASTAL WATERSHEDS; UNITED-STATES; EUTROPHICATION; NUTRIENT;
LIGHT; MODEL
AB Seagrasses provide important ecological services that directly or indirectly benefit human well-being and the environment. Excess nitrogen inputs are a major cause of eelgrass loss in the marine environment. Here we describe the results of a study aimed at quantifying the extent of eelgrass as a function of predicted watershed-derived nitrogen loading for small-to-medium-sized shallow estuaries in New England. Findings confirm that reduced extent of eelgrass corresponds to increased loading of nitrogen to this class of estuary. At lower levels of nitrogen loading (<= 50 Kg ha(-1) yr(-1)), eelgrass extent is variable and is likely controlled by other ecosystem factors unrelated to water quality. At higher loading rates, eelgrass coverage decreases markedly, with essentially no eelgrass at loading levels >= 100 Kg ha(-1) yr(-1). Published by Elsevier Ltd.
C1 [Latimer, James S.; Rego, Steven A.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA.
RP Latimer, JS (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA.
EM latimer.jim@epa.gov; rego.steven@epa.gov
RI Latimer, James/C-1632-2009
OI Latimer, James/0000-0002-6722-520X
FU U.S. Environmental Protection Agency
FX We would like to express our appreciation for the data and creative
insights provided by the following colleagues: Paul Stacey (CT DEP),
Scott Duerr (Town of Westerly), Scott Nixon (URI), Steve Halterman (MA
DEP), Russell Isaac (MA DEP), Tom Halavik (US FWS), Jamie Vaudrey
(University of Connecticut), and Ivan Valiela (Marine Biological
Laboratory), and the EPA technical reviewers. Special thanks to Jason
Grear for his help with R statistics. These varied and insightful
contributions added significantly to the quality of this manuscript.
Although the research described in this article has been funded by the
U.S. Environmental Protection Agency, it has not been subjected to
Agency review. Therefore, it does not necessarily reflect the views of
the Agency. AED contribution number AED - 09-070.
NR 60
TC 16
Z9 16
U1 1
U2 20
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0272-7714
EI 1096-0015
J9 ESTUAR COAST SHELF S
JI Estuar. Coast. Shelf Sci.
PD DEC 30
PY 2010
VL 90
IS 4
BP 231
EP 240
DI 10.1016/j.ecss.2010.09.004
PG 10
WC Marine & Freshwater Biology; Oceanography
SC Marine & Freshwater Biology; Oceanography
GA 692QC
UT WOS:000285169200008
ER
PT J
AU Lavoie, ET
Heine, LG
Holder, H
Rossi, MS
Lee, RE
Connor, EA
Vrabel, MA
Difiore, DM
Davies, CL
AF Lavoie, Emma T.
Heine, Lauren G.
Holder, Helen
Rossi, Mark S.
Lee, Robert E., II
Connor, Emily A.
Vrabel, Melanie A.
Difiore, David M.
Davies, Clive L.
TI Chemical Alternatives Assessment: Enabling Substitution to Safer
Chemicals
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
C1 [Lavoie, Emma T.; Lee, Robert E., II; Vrabel, Melanie A.; Difiore, David M.; Davies, Clive L.] US EPA, Design Environm Program, Washington, DC 20460 USA.
[Connor, Emily A.] ABT Associates Inc, Bethesda, MD 20814 USA.
[Heine, Lauren G.; Rossi, Mark S.] Clean Prod Act, Palo Alto, CA 94304 USA.
[Holder, Helen] Hewlett Packard Corp, Palo Alto, CA 94304 USA.
RP Lavoie, ET (reprint author), US EPA, Design Environm Program, 1200 Penn Ave,NW, Washington, DC 20460 USA.
EM lavoie.emma@epa.gov
NR 13
TC 35
Z9 36
U1 1
U2 13
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD DEC 15
PY 2010
VL 44
IS 24
BP 9244
EP 9249
DI 10.1021/es1015789
PG 6
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 694AK
UT WOS:000285266900002
PM 21062050
ER
PT J
AU Anastas, PT
Sonich-Mullin, C
Fried, B
AF Anastas, Paul T.
Sonich-Mullin, Cynthia
Fried, Becky
TI Designing Science in a Crisis: The Deepwater Horizon Oil Spill
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Editorial Material
C1 [Anastas, Paul T.; Sonich-Mullin, Cynthia; Fried, Becky] US EPA, Off Res & Dev, Washington, DC 20460 USA.
RP Anastas, PT (reprint author), US EPA, Off Res & Dev, Washington, DC 20460 USA.
EM anastas.paul@epa.gov; sonich-mullin.cynthia@epa.gov
RI Anastas, Paul/L-3258-2013
OI Anastas, Paul/0000-0003-4777-5172
NR 4
TC 9
Z9 10
U1 2
U2 16
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD DEC 15
PY 2010
VL 44
IS 24
BP 9250
EP 9251
DI 10.1021/es103700x
PG 2
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 694AK
UT WOS:000285266900003
PM 21073186
ER
PT J
AU Breen, MS
Breen, M
Williams, RW
Schultz, BD
AF Breen, Michael S.
Breen, Miyuki
Williams, Ronald W.
Schultz, Bradley D.
TI Predicting Residential Air Exchange Rates from Questionnaires and
Meteorology: Model Evaluation in Central North Carolina
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID PARTICULATE MATTER PANEL; UNITED-STATES; EXPOSURE; INDOOR;
DISTRIBUTIONS; OUTDOOR; PM2.5; WIND
AB A critical aspect of air pollution exposure models is the estimation of the air exchange rate (AER) of individual homes, where people spend most of their time. The AER, which is the airflow into and out of a building, is a primary mechanism for entry of outdoor air pollutants and removal of indoor source emissions. The mechanistic Lawrence Berkeley Laboratory (LBL) AER model was linked to a leakage area model to predict AER from questionnaires and meteorology. The LBL model was also extended to include natural ventilation (LBLX). Using literature-reported parameter values, AER predictions from LBL and LBLX models were compared to data from 642 daily AER measurements across 31 detached homes in central North Carolina, with corresponding questionnaires and meteorological observations. Data was collected on seven consecutive days during each of four consecutive seasons. For the individual model-predicted and measured AER, the median absolute difference was 43% (0.17 h(-1)) and 40% (0.17 h(-1)) for the LBL and LBLX models, respectively. Additionally, a literature-reported empirical scale factor (SF) AER model was evaluated, which showed a median absolute difference of 50% (0.25 h(-1)). The capability of the LBL, LBLX, and SF models could help reduce the AER uncertainty in air pollution exposure models used to develop exposure metrics for health studies.
C1 [Breen, Michael S.; Williams, Ronald W.; Schultz, Bradley D.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Breen, Miyuki] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Breen, Miyuki] N Carolina State Univ, Dept Math, Biomath Grad Program, Raleigh, NC 27695 USA.
RP Breen, MS (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
EM breen.michael@epa.gov
FU U.S. EPA through Office of Research and Development [68-D-99-012,
CR-828186]; U.S. Environmental Protection Agency; North Carolina State
University [CT833235-01-0]
FX We thank Tom Long, Jennifer Richmond-Bryant, Lisa Baxter, Alexander
Schneider, Haluk Ozkaynak, Alan Vette, Zhishi Guo, and Ronald Mosley for
review comments and helpful suggestions. We acknowledge Charles Rodes
and the staff of RTI International for their efforts in collecting the
household survey data. The U.S. EPA through its Office of Research and
Development designed, funded, and managed the RTP Panel Study described
here under contract 68-D-99-012 to the RTI International and to Shaw
University under collaborative agreement CR-828186. M.B. was supported
by the U.S. Environmental Protection Agency Cooperative Training Program
in Environmental Sciences Research with North Carolina State University,
Training Agreement CT833235-01-0. Although the manuscript was reviewed
by the U.S. Environmental Protection Agency and approved for
publication, it may not necessarily reflect official Agency policy.
Mention of trade names or commercial products does not constitute
endorsement or recommendation for use.
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PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD DEC 15
PY 2010
VL 44
IS 24
BP 9349
EP 9356
DI 10.1021/es101800k
PG 8
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 694AK
UT WOS:000285266900019
PM 21069949
ER
PT J
AU Schaum, J
Cohen, M
Perry, S
Artz, R
Draxler, R
Frithsen, JB
Heist, D
Lorber, M
Phillips, L
AF Schaum, John
Cohen, Mark
Perry, Steven
Artz, Richard
Draxler, Roland
Frithsen, Jeffrey B.
Heist, David
Lorber, Matthew
Phillips, Linda
TI Screening Level Assessment of Risks Due to Dioxin Emissions from Burning
Oil from the BP Deepwater Horizon Gulf of Mexico Spill
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID INDUSTRIAL SOURCE APPLICATIONS; DISPERSION MODEL; DEPOSITION; AERMOD
AB Between April 28 and July 19 of 2010, the U.S. Coast Guard conducted in situ oil burns as one approach used for the management of oil spilled after the explosion and subsequent sinking of the BP Deepwater Horizon platform in the Gulf of Mexico. The purpose of this paper is to describe a screening level assessment of the exposures and risks posed by the dioxin emissions from these fires. Using upper estimates for the oil burn emission factor, modeled air and fish concentrations, and conservative exposure assumptions, the potential cancer risk was estimated for three scenarios: inhalation exposure to workers, inhalation exposure to residents on the mainland, and fish ingestion exposures to residents. U.S. EPA's AERMOD model was used to estimate air concentrations in the immediate vicinity of the oil burns and NOAA's HYSPLIT model was used to estimate more distant air concentrations and deposition rates. The lifetime incremental cancer risks were estimated as 6 x 10(-8) for inhalation by workers, 6 x 10(-12) for inhalation by onshore residents, and 6 x 10(-8) for fish consumption by residents. For all scenarios, the risk estimates represent upper bounds and actual risks would be expected to be less.
C1 [Schaum, John; Frithsen, Jeffrey B.; Lorber, Matthew; Phillips, Linda] US EPA, Off Res & Dev, Washington, DC 20460 USA.
[Perry, Steven; Heist, David] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Cohen, Mark; Artz, Richard; Draxler, Roland] NOAA, Air Resources Lab, Silver Spring, MD 20910 USA.
RP Schaum, J (reprint author), US EPA, Off Res & Dev, Washington, DC 20460 USA.
EM schaum.john@epa.gov
RI Artz, Richard/P-6371-2015; Cohen, Mark/P-6936-2015
OI Artz, Richard/0000-0002-1335-0697; Cohen, Mark/0000-0003-3183-2558
NR 30
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U1 6
U2 60
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD DEC 15
PY 2010
VL 44
IS 24
BP 9383
EP 9389
DI 10.1021/es103559w
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 694AK
UT WOS:000285266900024
PM 21073188
ER
PT J
AU Aurell, J
Gullett, BK
AF Aurell, Johanna
Gullett, Brian K.
TI Aerostat Sampling of PCDD/PCDF Emissions from the Gulf Oil Spill In Situ
Burns
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID FIRES
AB Emissions from the in situ burning of oil in the Gulf of Mexico after the catastrophic failure of the Deepwater Horizon drilling platform were sampled for polychlorinated dibenzodioxins and polychlorinated dibenzofurans (PCDD/PCDF). A battery-operated instrument package was lofted into the plumes of 27 surface oil fires over a period of four days via a tethered aerostat to determine and characterize emissions of PCDD/PCDF. A single composite sample resulted in an emission factor of 2.0 ng toxic equivalency (TEQ) per kg of carbon burned, or 1.7 ng TEO per kg of oil burned, determined by a carbon balance method. Carbon was measured as CO(2) plus particulate matter, the latter of which has an emission factor of 0.088 kg/kg carbon burned. The average plume concentration approximately 200-300 m from the fire and about 75-200 m above sea level was <0.0002 ng TEQ/m(3).
C1 [Gullett, Brian K.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
RP Gullett, BK (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
EM gullett.brian@epa.gov
RI Aurell, Johanna/L-2046-2013
FU U.S. EPA, Office of Research and Development; National Risk Management
Research Laboratory, U.S. EPA; U.S. EPA [EP-C-09-27]
FX This work was funded and managed by the U.S. EPA, Office of Research and
Development. This research was performed while Johanna Aurell held a
National Research Council Research Associateship Award at the National
Risk Management Research Laboratory, U.S. EPA. Technical support for the
sampling mission was provided by Arcadis-US, Inc., under contract
EP-C-09-27 with the U.S. EPA. The aerostat piloting expertise provided
by Rob Gribble (ISSI, Inc.) and field crew support from Cheryl A.
Hawkins (U.S. EPA/OSRTI/ERT), Chris Pressley (U.S. EPA/ORD/NRMRL), James
Staves (U.S. EPA Region 6), and Steve Terll (Arcadis-US, Inc.) was
critical and much appreciated. The crews of the MV Allison and MV Jamie
G. are thanked for their hospitality and accommodation. The authors
recognize the critical analytical support and specialized expertise
provided by Dennis Tabor (U.S. EPA/ORD/NRMRL), Barbara Wyrzykowska and
Mike Tufts (Arcadis-US, Inc.), and Joseph Ferrario (U.S. EPA/OCSPP/OPP).
The authors acknowledge the quality assurance, on-site audits during
both the sampling and analysis phases, and procurement support of Robert
Wright and Paul Groff (U.S. EPA/ORD/NRMRL). Many people were critically
involved in the development, preparation, and implementation of the
sampling plan, including Sam Coleman (U.S. EPA Region 6), Wyman Briggs
and MSTCS Andrew Jaeger (USCG), Peter Collinson (BP), Jeffrey Frithsen
and John Schaum (U.S. EPA/ORD/NCEA), Marshall Gray (U.S. EPA/ORD/NERL),
Marc Greenberg and Brian Kovak (U.S. EPA/OSRTI/ERT), Dave Guinnup and
Richard Wayland (U.S. EPA/OAR/OAQPS), Nancy Jones and Jon Raucher (U.S.
EPA Region 6), Stacey Katz and Gail Robarge (U.S. EPA/ORD/NCER), Shawn
Ryan, Paul Lemieux, and Cynthia Sonich-Mullin (U.S. EPA/ORD/NHSRC),
Deborah McKean (U.S. EPA Region 8), Dana Tulis (U.S. EPA/OSWER/OEM), and
Lee Ann Veal (U.S. EPA/OAR/ORIA). The views expressed in this article
are those of the authors and do not necessarily reflect the views or
policies of the U.S. EPA. Mention of trade names or commercial products
does not constitute endorsement or recommendation for use.
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PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD DEC 15
PY 2010
VL 44
IS 24
BP 9431
EP 9437
DI 10.1021/es103554y
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 694AK
UT WOS:000285266900031
PM 21073185
ER
PT J
AU Costanza, J
Otano, G
Callaghan, J
Pennell, KD
AF Costanza, Jed
Otano, Gretell
Callaghan, John
Pennell, Kurt D.
TI PCE Oxidation by Sodium Persulfate in the Presence of Solids
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID ACTIVATED PERSULFATE; KINETICS; DEGRADATION; CHEMISTRY; WATER
AB Batch reactor experiments were performed to determine the effects of solids on the oxidation of tetracholoroethylene (PCE) by sodium persulfate in aqueous solution. Based on the rates of PCE degradation and chloride formation, PCE oxidation by heat-activated sodium persulfate at 50 degrees C in the presence of solids ranged from no detectable oxidation of PCE to the levels observed in water-only reactors. Repeated doses of sodium persulfate, undertaken to overcome the inherent solids oxidant demand, improved the rate and extent of PCE oxidation in reactors containing reference solids; however, no improvement was observed in reactors containing field soils. Additionally, no improvements in PCE oxidation were observed after pretreating Great Lakes and Appling soils with ca. 15 g/kg of sodium persulfate or 30% hydrogen peroxide to remove oxidizable fractions, or acetic acid to remove the carbonate fraction. Based on these results, in situ treatment of Great Lakes and Appling soils with heat-activated sodium persulfate is not anticipated to result in substantial PCE oxidation, while in situ treatment of Fort Lewis soils is anticipated to result in PCE oxidation. This work demonstrates the need to perform soil-specific contaminant treatability tests rather than soil oxidant demand tests when determining oxidant dosage requirements.
C1 [Costanza, Jed; Otano, Gretell; Callaghan, John; Pennell, Kurt D.] Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30332 USA.
RP Costanza, J (reprint author), US EPA, Washington, DC 20460 USA.
EM costanza.jed@epa.gov
RI Pennell, Kurt/F-6862-2010
OI Pennell, Kurt/0000-0002-5788-6397
FU Strategic Environmental Research and Development Program (SERDP)
[W912HQ-05-C-008, ER-1419]; GeorgiaTech
FX The authors thank Kyra P. Lynch and Jeff Powers, United States Corps of
Engineers, Seattle District, and Robert Davis, Jr., Tetra Tech NUS, Inc.
for providing access to soil and groundwater samples. Support for this
research was provided by the Strategic Environmental Research and
Development Program (SERDP) under contract W912HQ-05-C-008 for Project
ER-1419, "Investigation of Chemical Reactivity, Mass Recovery and
Biological Activity During Thermal Treatment of DNAPL" and by a
GeorgiaTech Presidential Undergraduate Research Award to John Callaghan.
This work has not been subject to SERDP review, and no official
endorsement should be inferred,
NR 14
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PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD DEC 15
PY 2010
VL 44
IS 24
BP 9445
EP 9450
DI 10.1021/es100997a
PG 6
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 694AK
UT WOS:000285266900033
PM 21070044
ER
PT J
AU Jordan, KC
Knuth, ML
Moyer-Mileur, LJ
Larson, RR
Sherwood, BE
McNutt, S
Quackenboss, JJ
Viet, SM
Melnyk, LJ
AF Jordan, Kristine C.
Knuth, Marilyn L.
Moyer-Mileur, Laurie J.
Larson, Rodney R.
Sherwood, Barbara E.
McNutt, Suzanne
Quackenboss, James J.
Viet, Susan M.
Melnyk, Lisa J.
TI Feasibility of community food item collection for the National
Children's Study
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE National Children's Study; Children; Diet and nutrition; Community;
Pesticides
ID PRESCHOOL-CHILDREN; DIETARY EXPOSURE; DAY-CARE; PESTICIDES;
ENVIRONMENTS; HOME
AB Background: The National Children's Study proposes to investigate biological, chemical, physical, and psychosocial environmental exposures and their role on health outcomes in pregnant women and children. One specific area of concern is contaminant exposure through the ingestion of solid foods. National food contaminant databases may miss dietary exposures unique to specific communities and sources of food.
Objective: The purpose of this study was to evaluate the feasibility of community food item collection for the assessment of pesticide exposure in pregnant women and young children.
Methods: A prospective observational design was used to test the food collection protocol in mothers (n = 45) of children aged 15-24 months in Salt Lake City, Utah. Foods for collection were based on: 1) frequency of different foods consumed by the target population as determined by the National Health and Nutrition Examination Survey data; 2) child food frequency questionnaire; and 3) likelihood of pesticide contamination in the foods. Assessment measures included: demographics, environmental health survey, quality assurance checklist, and participant evaluation form.
Results: An average of three food items were obtained from 44 households, yielding a collection rate of 97.8%. Overall, 100% of the food samples were rated as acceptable. Moreover, a vast majority of mothers reported that the study was not burdensome (95.5%) and that preparing the food sample was easy (93.2%).
Conclusions: This study suggests that the community food item collection methodology shows promise as a low-burden approach for capturing dietary exposures on a household level, and appears to be a feasible tool for large population studies to assess dietary exposures unique to specific communities. (C) 2010 Elsevier B.V All rights reserved.
C1 [Jordan, Kristine C.] Univ Utah, Div Nutr, Salt Lake City, UT 84112 USA.
[Knuth, Marilyn L.] Univ Utah, Sch Med, Dept Pediat, Salt Lake City, UT 84132 USA.
[Moyer-Mileur, Laurie J.] Univ Utah, Sch Med, Ctr Pediat Nutr Res, Salt Lake City, UT 84158 USA.
[Larson, Rodney R.] Univ Utah, Dept Family & Prevent Med, Rocky Mt Ctr Occ & Env Hlth, Salt Lake City, UT 84108 USA.
[Sherwood, Barbara E.] Promise Hosp Salt Lake, Salt Lake City, UT 84102 USA.
[McNutt, Suzanne; Viet, Susan M.] Westat Corp, Rockville, MD 20850 USA.
[Quackenboss, James J.] US EPA, Natl Exposure Res Lab, Las Vegas, NV 89119 USA.
[Melnyk, Lisa J.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
RP Jordan, KC (reprint author), Univ Utah, Div Nutr, 250 South,1850 East, Salt Lake City, UT 84112 USA.
EM kristine.jordan@hsc.utah.edu; marilyn.knuth@hsc.utah.edu;
laurie.moyer-mileur@hsc.utah.edu; rod.larson@hsc.utah.edu;
b.sherwood@comcast.net; SusieMcNutt@westat.com;
Quackenboss.james@epamail.epa.gov; susanviet@westat.com;
melnyk.lisa@epamail.epa.gov
RI Quackenboss, James/I-1960-2013
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U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0048-9697
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD DEC 15
PY 2010
VL 409
IS 2
BP 307
EP 313
DI 10.1016/j.scitotenv.2010.10.018
PG 7
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 707NW
UT WOS:000286294300009
PM 21067794
ER
PT J
AU Hughes, MF
Edwards, BC
Herbin-Davis, KM
Saunders, J
Styblo, M
Thomas, DJ
AF Hughes, Michael F.
Edwards, Brenda C.
Herbin-Davis, Karen M.
Saunders, Jesse
Styblo, Miroslav
Thomas, David J.
TI Arsenic (+3 oxidation state) methyltransferase genotype affects
steady-state distribution and clearance of arsenic in arsenate-treated
mice
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Arsenic; Methylation; Arsenic (+3 oxidation state) methyltransferase;
Gene knockout; Mouse
ID ATOMIC-ABSORPTION SPECTROMETRY; URINARY-EXCRETION; DRINKING-WATER;
METHYLATED METABOLITES; TRIVALENT ARSENICALS; DIMETHYLARSINIC ACID;
TISSUE DISTRIBUTION; TOXICITY; CANCER; BLADDER
AB Arsenic (+3 oxidation state) methyltransferase (As3mt) catalyzes formation of mono d1 and tri methylated metabolites of inorganic arsenic Distribution and retention of arsenic were compared in adult female As3mt knockout mice and wild-type C57BL/6 mice using a regimen in which mice received daily oral doses of 05 mg of arsenic as arsenate per kilogram of body weight Regardless of genotype arsenic body burdens attained steady state alter 10 daily doses At steady state arsenic body burdens in As3mt knockout mice were 16 to 20 times greater than in wild-type mice During the post dosing clearance period arsenic body burdens declined in As3mt knockout mice to similar to 35% and in wild-type mice to similar to 10% of steady-state levels Urinary concentration of arsenic was significantly lower in As3mt knockout mice than in wild type mice At steady state As3mt knockout mice had significantly higher fractions of the body burden of arsenic in liver kidney and urinary bladder than did wild-type mice These organs and lung had significantly higher arsenic concentrations than did corresponding organs from wild-type mice Inorganic arsenic was the predominant species in tissues of As3mt knockout mice tissues from wild type mice contained mixtures of inorganic arsenic and its methylated metabolites Diminished capacity for arsenic methylanon in As3mt knockout mice prolongs retention of inorganic arsenic in tissues and affects whole body clearance of arsenic Altered retention and tissue tropism of arsenic in As3mt knockout mice could affect the toxic or carcinogenic effects associated with exposure to this metalloid or its methylated metabolites (C) 2010 Published by Elsevier Inc
C1 [Hughes, Michael F.; Edwards, Brenda C.; Herbin-Davis, Karen M.; Thomas, David J.] US EPA, Pharmacokinet Branch, Integrated Syst Toxicol Div,Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Saunders, Jesse; Styblo, Miroslav] Univ N Carolina, Dept Nutr, Chapel Hill, NC 27599 USA.
RP Thomas, DJ (reprint author), US EPA, Pharmacokinet Branch, Integrated Syst Toxicol Div,Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
FU Gillings Innovation Laboratory [GIL 200710 0028]; NIH
[2R01ES010845-06A1]; Nutrition Obesity Research Center [DK 56350]
FX We thank Professor William Cullen for the generous gift of
trimethylarsine oxide Ms Grace Lee and Ms Felicia Walton provided
assistance in processing of tissues for arsenic speciation analysis
Analytical chemistry support was provided in part by a Gillings
Innovation Laboratory grant (GIL 200710 0028) to MS Additional support
was provided to MS by NIH 2R01ES010845-06A1 and a Nutrition Obesity
Research Center grant DK 56350 This article has been reviewed in
accordance with the policy of the National Health and Environmental
Effects Research Laboratory US Environmental Protection Agency and has
been approved for publication Approval does not signify that the
contents necessarily reflect the views and policies of the Agency nor
does mention of trade names or commercial products constitute
endorsement or recommendation for use
NR 43
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PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD DEC 15
PY 2010
VL 249
IS 3
BP 217
EP 223
DI 10.1016/j.taap.2010.09.017
PG 7
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 683UC
UT WOS:000284499700003
PM 20887743
ER
PT J
AU Sobus, JR
Pleil, JD
McClean, MD
Herrick, RF
Rappaport, SM
AF Sobus, Jon R.
Pleil, Joachim D.
McClean, Michael D.
Herrick, Robert F.
Rappaport, Stephen M.
TI Biomarker variance component estimation for exposure surrogate selection
and toxicokinetic inference
SO TOXICOLOGY LETTERS
LA English
DT Review
DE Biomarkers; Exposure; Variance components; PAHs
ID POLYCYCLIC AROMATIC-HYDROCARBONS; ASPHALT PAVING WORKERS; DERMAL
EXPOSURE; INHALATION; DETERMINANTS; VARIABILITY; BREATH; BLOOD; AIR
AB Biomarkers are useful exposure surrogates given their ability to integrate exposures through all routes and to reflect interindividual differences in toxicokinetic processes. Also, biomarker concentrations tend to vary less than corresponding environmental measurements, making them less-biasing surrogates for exposure. In this article, urinary PAH biomarkers (namely, urinary naphthalene [U-Nap]; urinary phenanthrene [U-Phe]; 1-hydroxypyrene [1-OH-Pyr]; and 1-, (2+3)-, 4-, and 9-hydroxyphenanthrene [1-, (2+3)-, 4-, and 9-OH-Phe]) were evaluated as surrogates for exposure to hot asphalt emissions using data from 20 road-paving workers. Linear mixed-effects models were used to estimate the within- and between-person components of variance for each urinary biomarker. The ratio of within- to between-person variance was then used to estimate the biasing effects of each biomarker on a theoretical exposure-response relationship. Mixed models were also used to estimate the amounts of variation in Phe metabolism to individual OH-Phe isomers that could be attributed to Phe exposure (as represented by U-Phe concentrations) and covariates representing time, hydration level, smoking status, age, and body mass index. Results showed that 1-OH-Phe, (2+3)-OH-Phe, and 1-OH-Pyr were the least-biasing surrogates for exposure to hot asphalt emissions, and that effects of hydration level and sample collection time substantially inflated bias estimates for the urinary biomarkers. Mixed-model results for the individual OH-Phe isomers showed that between 63% and 82% of the observed biomarker variance was collectively explained by Phe exposure, the time and day of sample collection, and the hydration level, smoking status, body mass index, and age of each worker. By difference, the model results also showed that, depending on the OH-Phe isomer, a maximum of 6-23% of the total biomarker variance was attributable to differences in unobserved toxicokinetic processes between the workers. Therefore, toxicokinetic processes are probably less influential on urinary biomarker variance than are exposures and observable covariate effects. The methods described in this analysis should be considered for the selection and interpretation of biomarkers as exposure surrogates in future exposure investigations. Published by Elsevier Ireland Ltd.
C1 [Sobus, Jon R.; Pleil, Joachim D.] US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[McClean, Michael D.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02118 USA.
[Herrick, Robert F.] Harvard Univ, Sch Publ Hlth, Exposure Epidemiol & Risk Program, Dept Environm Hlth,Landmark Ctr, Boston, MA 02215 USA.
[Rappaport, Stephen M.] Univ Calif Berkeley, Div Environm Hlth Sci, Sch Publ Hlth, Berkeley, CA 94720 USA.
RP Sobus, JR (reprint author), US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, Off Res & Dev, 109 TW Alexander Dr,Mail Code E205-04, Res Triangle Pk, NC 27711 USA.
EM sobus.jon@epa.gov; pleil.joachim@epa.gov; mmcclean@bu.edu;
herrick@hohp.harvard.edu; srappaport@berkeley.edu
RI McClean, Michael/J-2934-2015;
OI McClean, Michael/0000-0002-3902-8823; Pleil, Joachim/0000-0001-8211-0796
FU United States Environmental Protection Agency through its Office of
Research and Development; National Cancer Institute [R01 CA74413-03];
National Institutes of Health; National Institutes of Environmental
Health Sciences [T32ES07018, P42ES05948, P30ES10126]
FX The United States Environmental Protection Agency through its Office of
Research and Development partially funded and collaborated in the
research described here. It has been subjected to Agency review and
approved for publication. Additional funding was provided by the
National Cancer Institute (grant R01 CA74413-03) and the National
Institutes of Health; National Institutes of Environmental Health
Sciences (training grant T32ES07018, research grant P42ES05948, and
center grant P30ES10126). The authors are grateful for the expert advice
and assistance from Peter Egeghy, Rogelio Tornero-Velez, Ronald
Williams, Donald Whitaker, Marsha Morgan, Roy Fortmann, and Linda
Sheldon of U.S. EPA, Suramya Waidyanatha of NIEHS, David Kim of Syngenta
Crop Protection, Inc., and Lawrence Kupper of the University of North
Carolina at Chapel Hill.
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U1 2
U2 17
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0378-4274
J9 TOXICOL LETT
JI Toxicol. Lett.
PD DEC 15
PY 2010
VL 199
IS 3
BP 247
EP 253
DI 10.1016/j.toxlet.2010.09.006
PG 7
WC Toxicology
SC Toxicology
GA 694UT
UT WOS:000285325200007
PM 20851754
ER
PT J
AU Bierwagen, BG
Theobald, DM
Pyke, CR
Choate, A
Groth, P
Thomas, JV
Morefield, P
AF Bierwagen, Britta G.
Theobald, David M.
Pyke, Christopher R.
Choate, Anne
Groth, Philip
Thomas, John V.
Morefield, Philip
TI National housing and impervious surface scenarios for integrated climate
impact assessments
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE urbanization; land planning; water quality
ID LAND-USE CHANGE; CONTERMINOUS UNITED-STATES; TRENDS; EUROPE; STREAM;
COVER
AB Understanding the impacts of climate change on people and the environment requires an understanding of the dynamics of both climate and land use/land cover changes. A range of future climate scenarios is available for the conterminous United States that have been developed based on widely used international greenhouse gas emissions storylines. Climate scenarios derived from these emissions storylines have not been matched with logically consistent land use/cover maps for the United States. This gap is a critical barrier to conducting effective integrated assessments. This study develops novel national scenarios of housing density and impervious surface cover that are logically consistent with emissions storylines. Analysis of these scenarios suggests that combinations of climate and land use/cover can be important in determining environmental conditions regulated under the Clean Air and Clean Water Acts. We found significant differences in patterns of habitat loss and the distribution of potentially impaired watersheds among scenarios, indicating that compact development patterns can reduce habitat loss and the number of impaired watersheds. These scenarios are also associated with lower global greenhouse gas emissions and, consequently, the potential to reduce both the drivers of anthropogenic climate change and the impacts of changing conditions. The residential housing and impervious surface datasets provide a substantial first step toward comprehensive national land use/land cover scenarios, which have broad applicability for integrated assessments as these data and tools are publicly available.
C1 [Theobald, David M.] Colorado State Univ, Dept Human Dimens Nat Resources, Ft Collins, CO 80523 USA.
[Theobald, David M.] Colorado State Univ, Nat Resource Ecol Lab, Ft Collins, CO 80523 USA.
[Bierwagen, Britta G.; Morefield, Philip] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Global Change Res Program, Washington, DC 20460 USA.
[Pyke, Christopher R.] US Green Bldg Council, Washington, DC 20037 USA.
[Choate, Anne; Groth, Philip] ICF Int, Washington, DC 20006 USA.
[Thomas, John V.] US EPA, Off Policy Econ & Innovat, Dev Commun & Environm Div, Washington, DC 20460 USA.
RP Theobald, DM (reprint author), Colorado State Univ, Dept Human Dimens Nat Resources, Ft Collins, CO 80523 USA.
EM davet@cnr.colostate.edu
FU US Environmental Protection Agency [GS-10F-0234J, 1101]
FX This research was supported by Contract GS-10F-0234J, US Environmental
Protection Agency Order No. 1101. This report has undergone internal,
public, and external review (EPA/600/R-08/076A).
NR 29
TC 70
Z9 73
U1 1
U2 32
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD DEC 7
PY 2010
VL 107
IS 49
BP 20887
EP 20892
DI 10.1073/pnas.1002096107
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 690ZY
UT WOS:000285050800011
PM 21078956
ER
PT J
AU de Gonzalez, AB
Hartge, P
Cerhan, JR
Flint, AJ
Hannan, L
MacInnis, RJ
Moore, SC
Tobias, GS
Anton-Culver, H
Freeman, LB
Beeson, WL
Clipp, SL
English, DR
Folsom, AR
Freedman, DM
Giles, G
Hakansson, N
Henderson, KD
Hoffman-Bolton, J
Hoppin, JA
Koenig, KL
Lee, IM
Linet, MS
Park, Y
Pocobelli, G
Schatzkin, A
Sesso, HD
Weiderpass, E
Willcox, BJ
Wolk, A
Zeleniuch-Jacquotte, A
Willett, WC
Thun, MJ
AF de Gonzalez, Amy Berrington
Hartge, Patricia
Cerhan, James R.
Flint, Alan J.
Hannan, Lindsay
MacInnis, Robert J.
Moore, Steven C.
Tobias, Geoffrey S.
Anton-Culver, Hoda
Freeman, Laura Beane
Beeson, W. Lawrence
Clipp, Sandra L.
English, Dallas R.
Folsom, Aaron R.
Freedman, D. Michal
Giles, Graham
Hakansson, Niclas
Henderson, Katherine D.
Hoffman-Bolton, Judith
Hoppin, Jane A.
Koenig, Karen L.
Lee, I-Min
Linet, Martha S.
Park, Yikyung
Pocobelli, Gaia
Schatzkin, Arthur
Sesso, Howard D.
Weiderpass, Elisabete
Willcox, Bradley J.
Wolk, Alicja
Zeleniuch-Jacquotte, Anne
Willett, Walter C.
Thun, Michael J.
TI Body-Mass Index and Mortality among 1.46 Million White Adults.
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; CANCER SCREENING TRIAL; LOW-DOSE ASPIRIN;
CARDIOVASCULAR-DISEASE; BREAST-CANCER; PRIMARY PREVENTION;
UNITED-STATES; PREDICTING MORTALITY; PHYSICAL-ACTIVITY; WOMENS HEALTH
AB Background: A high body-mass index (BMI, the weight in kilograms divided by the square of the height in meters) is associated with increased mortality from cardiovascular disease and certain cancers, but the precise relationship between BMI and all-cause mortality remains uncertain.
Methods: We used Cox regression to estimate hazard ratios and 95% confidence intervals for an association between BMI and all-cause mortality, adjusting for age, study, physical activity, alcohol consumption, education, and marital status in pooled data from 19 prospective studies encompassing 1.46 million white adults, 19 to 84 years of age (median, 58).
Results: The median baseline BMI was 26.2. During a median follow-up period of 10 years (range, 5 to 28), 160,087 deaths were identified. Among healthy participants who never smoked, there was a J-shaped relationship between BMI and all-cause mortality. With a BMI of 22.5 to 24.9 as the reference category, hazard ratios among women were 1.47 (95 percent confidence interval [CI], 1.33 to 1.62) for a BMI of 15.0 to 18.4; 1.14 (95% CI, 1.07 to 1.22) for a BMI of 18.5 to 19.9; 1.00 (95% CI, 0.96 to 1.04) for a BMI of 20.0 to 22.4; 1.13 (95% CI, 1.09 to 1.17) for a BMI of 25.0 to 29.9; 1.44 (95% CI, 1.38 to 1.50) for a BMI of 30.0 to 34.9; 1.88 (95% CI, 1.77 to 2.00) for a BMI of 35.0 to 39.9; and 2.51 (95% CI, 2.30 to 2.73) for a BMI of 40.0 to 49.9. In general, the hazard ratios for the men were similar. Hazard ratios for a BMI below 20.0 were attenuated with longer-term follow-up.
Conclusions: In white adults, overweight and obesity (and possibly underweight) are associated with increased all-cause mortality. All-cause mortality is generally lowest with a BMI of 20.0 to 24.9.
N Engl J Med 2010;363:2211-9.
C1 [de Gonzalez, Amy Berrington] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
[Cerhan, James R.] Mayo Clin, Coll Med, Div Epidemiol, Rochester, MN USA.
[Flint, Alan J.; Willett, Walter C.] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
[Sesso, Howard D.] Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA.
[Sesso, Howard D.] Brigham & Womens Hosp, Div Aging, Boston, MA 02115 USA.
[Lee, I-Min] Harvard Univ, Sch Med, Boston, MA USA.
[Hannan, Lindsay; Thun, Michael J.] Amer Canc Soc, Dept Epidemiol & Surveillance Res, Atlanta, GA 30329 USA.
[MacInnis, Robert J.; English, Dallas R.] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia.
[Giles, Graham] Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.
[MacInnis, Robert J.] Univ Cambridge, Canc Res UK Genet Epidemiol Unit, Cambridge, England.
[Anton-Culver, Hoda] Univ Calif Irvine, Sch Med, Dept Epidemiol, Irvine, CA 92717 USA.
[Beeson, W. Lawrence] Loma Linda Univ, Sch Publ Hlth, Loma Linda, CA 92350 USA.
[Henderson, Katherine D.] City Hope Natl Med Ctr, Dept Populat Sci, Duarte, CA 91010 USA.
[Clipp, Sandra L.; Hoffman-Bolton, Judith] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
[Folsom, Aaron R.] Univ Minnesota, Sch Publ Hlth, Minneapolis, MN USA.
[Hakansson, Niclas; Wolk, Alicja] Karolinska Inst, Natl Inst Environm Med, Div Nutr Epidemiol, Stockholm, Sweden.
[Weiderpass, Elisabete] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
[Hoppin, Jane A.] Natl Inst Environm Hlth Sci, Epidemiol Branch, Res Triangle Pk, NC USA.
[Koenig, Karen L.; Zeleniuch-Jacquotte, Anne] NYU, Sch Med, Dept Environm Med, New York, NY USA.
[Pocobelli, Gaia] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.
[Pocobelli, Gaia] Fred Hutchinson Canc Res Ctr, Canc Prevent Program, Seattle, WA 98104 USA.
[Weiderpass, Elisabete] Canc Registry Norway, Oslo, Norway.
[Weiderpass, Elisabete] Dept Community Med, Tromso, Norway.
[Weiderpass, Elisabete] Samfundet Folkhalsan, Helsinki, Finland.
[Willcox, Bradley J.] Pacific Hlth Res Inst, Honolulu, HI USA.
[Willcox, Bradley J.] Queens Med Ctr, Honolulu, HI USA.
RP de Gonzalez, AB (reprint author), NCI, Div Canc Epidemiol & Genet, NIH, Rm 7034,6120 Execut Blvd, Bethesda, MD 20892 USA.
EM berringtona@mail.nih.gov
RI Hakansson, Niclas/L-7913-2013; Tobias, Geoffrey/M-4135-2016; Weiderpass,
Elisabete/M-4029-2016; Beane Freeman, Laura/C-4468-2015; Moore,
Steven/D-8760-2016;
OI English, Dallas/0000-0001-7828-8188; Park, Yikyung/0000-0002-6281-489X;
Hakansson, Niclas/0000-0001-7673-5554; Tobias,
Geoffrey/0000-0002-2878-8253; Weiderpass, Elisabete/0000-0003-2237-0128;
Beane Freeman, Laura/0000-0003-1294-4124; Moore,
Steven/0000-0002-8169-1661; Giles, Graham/0000-0003-4946-9099
FU National Institutes of Health (NIH); Division of Cancer Control and
Population Sciences, National Cancer Institute (NCI), NIH; Iovate Health
Sciences USA
FX Supported by the Intramural Research Program of the National Institutes
of Health (NIH) and the Division of Cancer Control and Population
Sciences, National Cancer Institute (NCI), NIH. Details regarding
funding for the individual studies are listed in the Supplementary
Appendix.; Dr. Sesso reports receiving consulting fees from Iovate
Health Sciences USA. No other potential conflict of interest relevant to
this article was reported.
NR 45
TC 418
Z9 429
U1 5
U2 60
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD DEC 2
PY 2010
VL 363
IS 23
BP 2211
EP 2219
PG 9
WC Medicine, General & Internal
SC General & Internal Medicine
GA 688EP
UT WOS:000284832900008
ER
PT J
AU Carbone, M
Baris, YI
Bertino, P
Brass, B
Dogan, U
Emri, S
Gaudino, G
Gultekin, M
Jube, S
Kanodia, S
Lockey, J
Partridge, CR
Rinaudo, C
Rivera, Z
Ryan, PH
Sens, MA
Steele, I
Tuncer, M
Way, S
Yang, H
Miller, A
AF Carbone, M.
Baris, Y. I.
Bertino, P.
Brass, B.
Dogan, U.
Emri, S.
Gaudino, G.
Gultekin, M.
Jube, S.
Kanodia, S.
Lockey, J.
Partridge, C. R.
Rinaudo, C.
Rivera, Z.
Ryan, P. H.
Sens, M. A.
Steele, I.
Tuncer, M.
Way, S.
Yang, H.
Miller, A.
TI Erionite Exposure in North Dakota is Comparable to That Found in Turkish
Villages Which Experience a High Incidence of Mesothelioma
SO JOURNAL OF THORACIC ONCOLOGY
LA English
DT Meeting Abstract
C1 [Carbone, M.; Bertino, P.; Gaudino, G.; Jube, S.; Kanodia, S.; Rivera, Z.; Yang, H.] Univ Hawaii, Univ Hawaii Canc Ctr, Honolulu, HI 96822 USA.
[Baris, Y. I.; Emri, S.; Tuncer, M.] Hacettepe Univ, Ankara, Turkey.
[Brass, B.; Partridge, C. R.; Way, S.] US EPA, Denver, CO USA.
[Dogan, U.] Univ Iowa, Iowa City, IA USA.
[Gultekin, M.; Tuncer, M.] Turkish Minist Hlth, Ankara, Turkey.
[Lockey, J.; Ryan, P. H.] Univ Cincinnati, Cincinnati, OH USA.
[Rinaudo, C.] Univ Piemonte Orientale, Alessandria, Italy.
[Rivera, Z.] Univ Hawaii, Dept Mol Biosci & Bioengn, Honolulu, HI 96822 USA.
[Sens, M. A.] Univ N Dakota, Grand Forks, ND 58201 USA.
[Steele, I.] Univ Chicago, Chicago, IL 60637 USA.
[Yang, H.] Univ Hawaii, John A Burns Sch Med, Honolulu, HI 96822 USA.
[Miller, A.] NIEHS, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1556-0864
J9 J THORAC ONCOL
JI J. Thorac. Oncol.
PD DEC
PY 2010
VL 5
IS 12
SU 7
BP S561
EP S561
PG 1
WC Oncology; Respiratory System
SC Oncology; Respiratory System
GA 690HQ
UT WOS:000284994100154
ER
PT J
AU Tal, A
Gordon, J
AF Tal, Alon
Gordon, Jessica
TI Carbon Cautious: Israel's Afforestation Experience and Approach to
Sequestration
SO SMALL-SCALE FORESTRY
LA English
DT Article
DE Forestry policies; Israel; Carbon; Sequestration
ID PINUS-HALEPENSIS; ALEPPO PINE; ORGANIC-CARBON; SOIL; FORESTS; CLIMATE;
PLANTATIONS; POLICY; BIODIVERSITY; PROVENANCES
AB During the past 60 years, afforestation has transformed Israel's landscape, with forests planted or planned on 10% of the country's land, much of it with less than 300 mm of annual precipitation. After early efforts to establish a successful commercial timber industry failed, recreation and ecosystem services came to dominate forestry policy objectives. Given Israel's status as a 'developing country' under the Kyoto Protocol, forests' economic potential through carbon sequestration has been explored, but has not yet proven to be compelling. Several considerations cooled initial enthusiasm for seeking international carbon credits through afforestation. These include administrative obstacles associated with international accreditation, limited potential economic profitability, and ethical considerations. Rather, a voluntary offsetting program was adopted, allowing donors to plant trees in Israel, that balance individual carbon emissions. Afforestation in drylands exhibit meaningful potential to counteract chronic carbon loss due to land degradation. As trees planted in Israel's semi-arid regions exhibit surprisingly high carbon sequestration properties that are comparable to forests in temperate Europe, the potential for offsetting may become a growing factor in local forestry policy once Israel begins to regulate CO2 emissions.
C1 [Tal, Alon] Ben Gurion Univ Negev, Mitrani Dept Desert Ecol, Sede Boqer, Israel.
[Tal, Alon] KKL JNF, Land Dev Comm, Jerusalem, Israel.
[Gordon, Jessica] US EPA, Washington, DC 20460 USA.
RP Tal, A (reprint author), Ben Gurion Univ Negev, Mitrani Dept Desert Ecol, Sede Boqer, Israel.
EM alontal@bgu.ac.il
NR 83
TC 10
Z9 10
U1 2
U2 14
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1873-7617
J9 SMALL-SCALE FOR
JI Small-Scale For.
PD DEC
PY 2010
VL 9
IS 4
SI SI
BP 409
EP 428
DI 10.1007/s11842-010-9125-z
PG 20
WC Forestry
SC Forestry
GA 714LM
UT WOS:000286811100002
ER
PT J
AU Barbour, MT
Bierwagen, BG
Hamilton, AT
Aumen, NG
AF Barbour, Michael T.
Bierwagen, Britta G.
Hamilton, Anna T.
Aumen, Nicholas G.
TI Climate change and biological indicators: detection, attribution, and
management implications for aquatic ecosystems
SO JOURNAL OF THE NORTH AMERICAN BENTHOLOGICAL SOCIETY
LA English
DT Article
C1 [Barbour, Michael T.] Tetra Tech Inc, Ctr Ecol Sci, Owings Mills, MD 21117 USA.
[Bierwagen, Britta G.] US EPA, Global Change Res Program, Washington, DC 20460 USA.
[Hamilton, Anna T.] Tetra Tech Inc, Ctr Ecol Sci, Santa Fe, NM 87505 USA.
[Aumen, Nicholas G.] Loxahatchee Natl Wildlife Refuge, Boynton Beach, FL 33473 USA.
RP Barbour, MT (reprint author), Tetra Tech Inc, Ctr Ecol Sci, 400 Red Brook Blvd,Suite 200, Owings Mills, MD 21117 USA.
EM michael.barbour@tetratech.com; bierwagen.britta@epa.gov;
anna.hamilton@tetratech.com; nick_aumen@nps.gov
RI Bierwagen, Britta/G-5943-2010
NR 18
TC 3
Z9 4
U1 2
U2 14
PU NORTH AMER BENTHOLOGICAL SOC
PI LAWRENCE
PA 1041 NEW HAMSPHIRE STREET, LAWRENCE, KS 66044 USA
SN 0887-3593
J9 J N AM BENTHOL SOC
JI J. N. Am. Benthol. Soc.
PD DEC
PY 2010
VL 29
IS 4
BP 1349
EP 1353
DI 10.1899/10-117.1
PG 5
WC Ecology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA 676EB
UT WOS:000283891800013
ER
PT J
AU Hamilton, AT
Stamp, JD
Bierwagen, BG
AF Hamilton, Anna T.
Stamp, Jennifer D.
Bierwagen, Britta G.
TI Vulnerability of biological metrics and multimetric indices to effects
of climate change
SO JOURNAL OF THE NORTH AMERICAN BENTHOLOGICAL SOCIETY
LA English
DT Article
DE climate change; biological indicators; biological metrics; multimetric
indices; vulnerability; biomonitoring; macroinvertebrates
ID STREAM MACROINVERTEBRATE COMMUNITIES; UPPER RHONE-RIVER; WATER-QUALITY;
UNITED-STATES; LAND-USE; EUROPEAN STREAMS; SPECIES RICHNESS; ORGANISM
GROUPS; BIOTIC INDEX; STAR PROJECT
AB Aquatic ecosystems and their fauna are vulnerable to a variety of climate-related changes. Benthic macroinvertebrates are used frequently by water-quality agencies to monitor the status of aquatic resources. We used several regionally distributed state bioassessment data sets to analyze how climate change might influence metrics used to define ecological condition of streams. Many widely used, taxonomically based metrics were composed of both cold- and warm-water-preference taxa, and differing responses of these temperature-preference groups to climate-induced changes in stream temperatures could undermine assessment of stream condition. Climate responsiveness of these trait groups varied among states and ecoregions, but the groups generally were sensitive to changing temperature conditions. Temperature sensitivity of taxa and their sensitivity to organic pollution were moderately but significantly correlated. Therefore, metrics selected for condition assessments because taxa are sensitive to disturbance or to conventional pollutants also were sensitive to changes in temperature. We explored the feasibility of modifying metrics by partitioning components based on temperature sensitivity to reduce the likelihood that responses to climate change would confound responses to impairment from other causes and to facilitate tracking of climate-change-related taxon losses and replacements.
C1 [Hamilton, Anna T.] Tetra Tech Inc, Santa Fe, NM 87505 USA.
[Stamp, Jennifer D.] Tetra Tech Inc, Montpelier, VT 05602 USA.
[Bierwagen, Britta G.] US EPA, Global Change Res Program, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
RP Hamilton, AT (reprint author), Tetra Tech Inc, 502 W Cordova Rd,Suite C, Santa Fe, NM 87505 USA.
EM anna.hamilton@tetratech.com; jen.stamp@tetratech.com;
bierwagen.britta@epa.gov
RI Bierwagen, Britta/G-5943-2010
FU US EPA [GS-10E-0268K, DO 1101, DO 1107]
FX We thank the US EPA Global Change Research Program (GCRP) for providing
funding for this project through contracts GS-10E-0268K, DO 1101, and DO
1107 to Tetra Tech, Inc., and the GCRP staff in the National Center for
Environmental Assessment (NCEA), especially S. Julius, for their input
and advice throughout the development of this project. We also thank
staff in the Office of Science and Technology in the US EPA Office of
Water for their input and assistance; staff in state offices who
contributed data, reviewed approaches, and assisted with the development
of the traits database; and representatives on the regional workgroups
for their input and review during critical phases of the project. The
views expressed in this article are those of the authors, and they do
not necessarily reflect the views or policies of the US EPA.
NR 65
TC 13
Z9 13
U1 1
U2 21
PU NORTH AMER BENTHOLOGICAL SOC
PI LAWRENCE
PA 1041 NEW HAMSPHIRE STREET, LAWRENCE, KS 66044 USA
SN 0887-3593
J9 J N AM BENTHOL SOC
JI J. N. Am. Benthol. Soc.
PD DEC
PY 2010
VL 29
IS 4
BP 1379
EP 1396
DI 10.1899/10-053.1
PG 18
WC Ecology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA 676EB
UT WOS:000283891800016
ER
PT J
AU Stamp, JD
Hamilton, AT
Zheng, L
Bierwagen, BG
AF Stamp, Jennifer D.
Hamilton, Anna T.
Zheng, Lei
Bierwagen, Britta G.
TI Use of thermal preference metrics to examine state biomonitoring data
for climate change effects
SO JOURNAL OF THE NORTH AMERICAN BENTHOLOGICAL SOCIETY
LA English
DT Article
DE traits; climate change; macroinvertebrates; biomonitoring; temperature;
hydrology; cold-water taxa; warm-water taxa
ID CONTERMINOUS UNITED-STATES; UPPER RHONE RIVER; SPECIES TRAITS;
BIOLOGICAL TRAITS; INVERTEBRATE TRAITS; BENTHIC MACROINVERTEBRATES;
STREAM MACROINVERTEBRATES; HABITAT TEMPLET; COMMUNITIES; TAXA
AB Analyses of long-term data are an important component of climate-change research because they can help further our understanding of the effects of climate change and can help establish expectations for biological responses to future climate changes. We used macroinvertebrate data to assess whether biological trends associated with directional climate change could be detected in routine biomonitoring data from Maine, North Carolina, and Utah. We analyzed data from 8 long-term biomonitoring sites that had 9 to 22 y of data, and focused on thermal-preference metrics based on cold- and warm-water-preference trait groups. The thermal-preference metrics were derived primarily from weighted-average or generalized-linear-model inferences based on data from each state database and are region specific. Long-term trends varied across sites and regions. At some sites, the thermal-preference metrics showed significant patterns that could be interpreted as being related to directional climate change, whereas at others, patterns were not as expected or were not evident. The strongest trends occurred at 2 Utah sites that had >= 14 y of data. At these sites, cold-water taxa were negatively correlated with air temperature, and, when years were grouped into hottest- and coldest-year samples, were strongly reduced in the hottest-year samples. Results suggest that thermal-preference metrics show promise for application in a biomonitoring context to differentiate climate-related responses from other stressors.
C1 [Stamp, Jennifer D.] Tetra Tech Inc, Ctr Ecol Sci, Montpelier, VT 05602 USA.
[Hamilton, Anna T.] Tetra Tech Inc, Ctr Ecol Sci, Santa Fe, NM 87505 USA.
[Zheng, Lei] Tetra Tech Inc, Ctr Ecol Sci, Owings Mills, MD 21117 USA.
[Bierwagen, Britta G.] US EPA, Global Change Res Program, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
RP Stamp, JD (reprint author), Tetra Tech Inc, Ctr Ecol Sci, 73 Main St,Suite 38, Montpelier, VT 05602 USA.
EM jen.stamp@tetratech.com; anna.hamilton@tetratech.com;
lei.zheng@tetratech.com; bierwagen.britta@epa.gov
RI Bierwagen, Britta/G-5943-2010
FU US EPA Office of Research and Development [GS-10F-0268K, DO 1107]
FX The authors thank the staff from the US EPA's Office of Science and
Technology for their input throughout this research. A number of state
representatives made important contributions to the project. They
include T. MacPherson (formerly) from North Carolina DENR; L. Tsomides,
T. Danielson, and S. Meidel from Maine Department of Environmental
Protection; J. Ostermiller from Utah Division of Water Quality; and
members of the Vermont Department of Environmental Conservation
Bio-monitoring and Aquatic Studies Section. We also thank E. Leppo and
B. Jessup from Tetra Tech for their assistance in acquiring and
analyzing data. We are extremely grateful for all of their
contributions. The Global Change Research Program in the National Center
for Environmental Assessment in the US EPA Office of Research and
Development provided financial support for some of the analyses
contributing to this paper through contract GS-10F-0268K, DO 1107 to
Tetra Tech, Inc. The views expressed in this article are those of the
authors, and they do not necessarily reflect the views or policies of
the US EPA.
NR 57
TC 12
Z9 13
U1 3
U2 24
PU NORTH AMER BENTHOLOGICAL SOC
PI LAWRENCE
PA 1041 NEW HAMSPHIRE STREET, LAWRENCE, KS 66044 USA
SN 0887-3593
J9 J N AM BENTHOL SOC
JI J. N. Am. Benthol. Soc.
PD DEC
PY 2010
VL 29
IS 4
BP 1410
EP 1423
DI 10.1899/10-003.1
PG 14
WC Ecology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA 676EB
UT WOS:000283891800018
ER
PT J
AU Waschmann, RS
Watrud, LS
Reece, LR
Shiroyama, T
AF Waschmann, Ronald S.
Watrud, Lidia S.
Reece, Leon R.
Shiroyama, Tamotsu
TI Sunlit mesocosms designed for pollen confinement and risk assessment of
transgenic crops
SO AEROBIOLOGIA
LA English
DT Article
DE Gene flow; Modified open top chambers; Plant communities; Pollen filter
ID OPEN-TOP CHAMBERS; OZONE EXPOSURE; ATMOSPHERIC CO2; FOLIAR INJURY;
AIR-POLLUTION; GAS-EXCHANGE; PLANT-GROWTH; FIELD; MICROCLIMATE; FOREST
AB To minimize concerns about the ecological consequences of wind and insect dispersal of pollen and the potential of gene flow from experimental genetically modified (GM) crops to compatible relatives, we have modified outdoor sunlit open top chambers (OTCs) for use with GM plants. We have redesigned 21 cylindrical OTCs, commonly used to study the effects of atmospheric pollutants, by adding (1) a pollen filter at the top of each unit to minimize the possibility of the escape of GM pollen; with pollen filters in place, the OTCs are referred to as mesocosms, (2) an evaporative cooler to help mitigate elevated temperatures during the summer months, and (3) an automated watering system that eliminates the need to enter a mesocosm for irrigation during pollination, thereby minimizing potential pollen escape and entry of insect pollinators. Each sunlit mesocosm contains three large plastic pots (each with 1.2-m(2) surface area) that simulate field plots and that contain a constructed plant community. For example, the community may consist of a GM and a non-GM cultivar of canola (Brassica napus), compatible weedy relatives, and non-compatible species that may be found in mesic disturbed areas such as roadsides or ditches beyond crop fields. The sunlit mesocosms provide a well-replicated outdoor testing system that confines pollen and that can be used to precede or supplement field tests that evaluate the potential ecological consequences of transgenic crops. The mesocosms are proposed as test systems in which transgenic crops and other plants (e. g., biofuel crops) that have been proposed to be grown in new geographies, or plants that produce novel compounds, may be studied to evaluate their potential effects on plant communities. The pollen confinement and insect exclusion features of our mesocosms may also minimize exposure of sensitive humans and insect pollinators to pollen and cellular debris from other plant parts.
C1 [Waschmann, Ronald S.; Watrud, Lidia S.; Shiroyama, Tamotsu] US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA.
[Reece, Leon R.] Natl Asian Pacific Ctr Aging, Seattle, WA 98101 USA.
RP Waschmann, RS (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, 200 SW 35th St, Corvallis, OR 97333 USA.
EM waschmann.ron@epa.gov
FU US Environmental Protection Agency
FX George King, Fred Senecal, and Milton Plocher, Dynamac Corporation, are
thanked for their roles in installing TDR sensors and irrigation systems
and in assisting in installation of pollen filters in the mesocosms.
Jason Londo, Michael Bollman, and Bonnie Smith are thanked for their
assistance in refining the design and testing of pollen filter
efficiency. Richard Norby, Henry E. Lee and Bob Ozretich are thanked for
their insightful comments on earlier drafts of this manuscript. The
information in this document has been funded wholly (or in part) by the
US Environmental Protection Agency. It has been subjected to review by
the National Health and Environmental Effects Research Laboratory's
Western Ecology Division and approved for publication. Approval does not
signify that the contents reflect the views of the Agency, nor does
mention of trade names or commercial products constitute endorsement or
recommendation for use.
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PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0393-5965
J9 AEROBIOLOGIA
JI Aerobiologia
PD DEC
PY 2010
VL 26
IS 4
BP 311
EP 325
DI 10.1007/s10453-010-9167-x
PG 15
WC Biology; Environmental Sciences
SC Life Sciences & Biomedicine - Other Topics; Environmental Sciences &
Ecology
GA 666SI
UT WOS:000283139000006
ER
PT J
AU Stock, TH
Chung, KC
Smith, T
Alesch, A
Swift, J
Afshar, M
AF Stock, Thomas H.
Chung, Kuenja C.
Smith, Timothy
Alesch, Amy
Swift, Julie
Afshar, Masoud
TI Investigation of spatial and seasonal variation of VOCs at the Ysleta
del Sur Pueblo American Indian nation
SO AIR QUALITY ATMOSPHERE AND HEALTH
LA English
DT Article
DE VOCs; Air toxics; American Indian nation; Passive air monitoring; Method
comparison
AB The Ysleta del Sur Pueblo Environmental Management Office utilized passive air samplers to collect baseline data that can be used in the characterization of Tribal community exposures to ambient air toxics. These passive devices were deployed at ten separate sites. Five of these sites are representative of a housing subdivision (Old Reservation) that is located within the city limits of El Paso, TX, which is characterized as urban/suburban. The remaining five sites are situated in another housing subdivision (New Reservation) that is approximately 8 km southeast, in the city of Socorro, TX, in a rural area surrounded by agricultural fields. The project consisted of two distinct study phases, with each phase corresponding to different weather seasons. The first phase occurred from June through August (warm season), and the second phase occurred from November through February (cool season). During each study phase, passive samplers were deployed for 72 h on five separate occasions, mostly at 18-day intervals. Also, conventional 24-h canister monitoring was conducted at one of the monitoring sites in the Old Reservation for a period of 1 year with data collection occurring once every 6 days. Measurements from the two methods occurring during overlapping monitoring periods were found to be comparable, as were the estimates of precision for each method. Monitoring results indicated significant differences in concentrations of most volatile organic chemicals between reservations and between seasons, with automotive emissions the likely major determinant of levels of the majority of the quantifiable compounds.
C1 [Stock, Thomas H.; Afshar, Masoud] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Houston, TX 77030 USA.
[Chung, Kuenja C.] US EPA, Dallas, TX 75202 USA.
[Smith, Timothy; Alesch, Amy] Ysleta del Sur Pueblo Environm Management Off, Tribal Air Program, El Paso, TX 79907 USA.
[Swift, Julie] Eastern Res Grp Inc, Morrisville, NC 27560 USA.
RP Stock, TH (reprint author), Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, 1200 Herman Pressler Dr, Houston, TX 77030 USA.
EM thomas.h.stock@uth.tmc.edu
FU EPA Tribal Air Grant
FX This study was conducted by the YDSP American Indian Nation under
contracts to University of Texas Health Science Center at Houston,
School of Public Health, and Eastern Research Group, Inc. The study was
funded by an EPA Tribal Air Grant. Mention of trade names or commercial
products does not constitute an endorsement or recommendation for use.
The authors would like to acknowledge Gary Richardson for his
significant effort on the field study.
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PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1873-9318
J9 AIR QUAL ATMOS HLTH
JI Air Qual. Atmos. Health
PD DEC
PY 2010
VL 3
IS 4
BP 213
EP 224
DI 10.1007/s11869-010-0071-x
PG 12
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA V25HX
UT WOS:000208470200004
ER
PT J
AU Zheng, CL
Wang, LY
Li, R
Ma, B
Tu, L
Xu, XZ
Dackor, RT
Zeldin, DC
Wang, DW
AF Zheng, Changlong
Wang, Luyun
Li, Rui
Ma, Ben
Tu, Ling
Xu, Xizhen
Dackor, Ryan T.
Zeldin, Darryl C.
Wang, Dao Wen
TI Gene Delivery of Cytochrome P450 Epoxygenase Ameliorates
Monocrotaline-Induced Pulmonary Artery Hypertension in Rats
SO AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
LA English
DT Article
DE arachidonic acids; cytochrome P450 epoxygenase; gene therapy;
monocrotaline
ID NITRIC-OXIDE SYNTHASE; GROWTH-FACTOR-BETA; SOLUBLE EPOXIDE HYDROLASE;
ACTIVATED PROTEIN-KINASE; ENDOTHELIAL-CELL GROWTH; EPOXYEICOSATRIENOIC
ACIDS; SMOOTH-MUSCLE; SIGNALING PATHWAYS; 5,6-EPOXYEICOSATRIENOIC ACID;
GERMLINE MUTATIONS
AB Pulmonary arterial hypertension (PAH) is a life-threatening disease that leads to progressive pulmonary hypertension, right heart failure, and death. Endothelial dysfunction and inflammation were implicated in the pathogenesis of PAH. Epoxyeicosatrienoic acids (EETs), products of the cytochrome P450 epoxygenase metabolism of arachidonic acid, are potent vasodilators that possess anti-inflammatory and other protective properties in endothelial cells. We investigated whether gene delivery with the human cytochrome P450 epoxygenase 2J2 (CYP2J2) ameliorates monocrotaline (MCT)-induced pulmonary hypertension in rats. Significant pulmonary hypertension developed 3 weeks after the administration of MCT, but gene therapy with CYP2J2 significantly attenuated the development of pulmonary hypertension and pulmonary vascular remodeling, without causing changes in systemic arterial pressure or heart rate. These effects were associated with increased pulmonary endothelial NO synthase (eNOS) expression and its activity, inhibition of inflammation in the lungs, and transforming growth factor (TGF)-beta/type II bonemorphogenetic protein receptor (BMPRII)-drosophila mothers against decapentaplegic proteins (Smads) signaling. Collectively, these data suggest that gene therapy with CYP2J2 may have potential as a novel therapeutic approach to this progressive and oftentimes lethal disorder.
C1 [Zheng, Changlong; Wang, Luyun; Li, Rui; Ma, Ben; Tu, Ling; Xu, Xizhen; Wang, Dao Wen] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Internal Med, Wuhan 430030, Peoples R China.
[Zheng, Changlong; Wang, Luyun; Li, Rui; Ma, Ben; Tu, Ling; Xu, Xizhen; Wang, Dao Wen] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Gene Therapy Ctr, Wuhan 430030, Peoples R China.
[Dackor, Ryan T.; Zeldin, Darryl C.] Natl Inst Environm Hlth Sci, Div Intramural Res, NIH, Res Triangle Pk, NC USA.
RP Wang, DW (reprint author), Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Internal Med, Wuhan 430030, Peoples R China.
EM dwwang@tjh.tjmu.edu.cn
FU 973 Program [2007CB512004, 2006CB503801]; National Nature Science
Foundation Committee of China [30430320, 30971247]; National Institute
of Environmental Health Sciences at the National Institutes of Health
[Z01 ES025034]
FX This work was supported by grants 2007CB512004 and 2006CB503801 from the
973 Program, and by grants 30430320 and 30971247 from National Nature
Science Foundation Committee of China. This work was also supported, in
part, by grant Z01 ES025034 from the Intramural Research Program of the
National Institute of Environmental Health Sciences at the National
Institutes of Health.
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PU AMER THORACIC SOC
PI NEW YORK
PA 61 BROADWAY, FL 4, NEW YORK, NY 10006 USA
SN 1044-1549
J9 AM J RESP CELL MOL
JI Am. J. Respir. Cell Mol. Biol.
PD DEC
PY 2010
VL 43
IS 6
BP 740
EP 749
DI 10.1165/rcmb.2009-0161OC
PG 10
WC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
SC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
GA 690OD
UT WOS:000285013200013
PM 20118222
ER
PT J
AU Berrocal, VJ
Gelfand, AE
Holland, DM
AF Berrocal, Veronica J.
Gelfand, Alan E.
Holland, David M.
TI A BIVARIATE SPACE-TIME DOWNSCALER UNDER SPACE AND TIME MISALIGNMENT
SO ANNALS OF APPLIED STATISTICS
LA English
DT Article
DE Co-kriging; coregionalization; dynamic model; kriging; multivariate
spatial process; spatially varying coefficients
ID MULTIVARIATE SPATIAL INTERPOLATION; PARTICULATE AIR-POLLUTION;
NUMERICAL-MODELS; COVARIANCE FUNCTIONS; DAILY MORTALITY; US CITIES;
PREDICTION; CMAQ; EXPOSURE; FIELDS
AB Ozone and particulate matter, PM(2.5), are co-pollutants that have long been associated with increased public health risks. Information on concentration levels for both pollutants comes from two sources: monitoring sites and output from complex numerical models that produce concentration surfaces over large spatial regions. In this paper, we offer a fully-model-based approach for fusing these two sources of information for the pair of co-pollutants which is computationally feasible over large spatial regions and long periods of time. Due to the association between concentration levels of the two environmental contaminants, it is expected that information regarding one will help to improve prediction of the other. Misalignment is an obvious issue since the monitoring networks for the two contaminants only partly intersect and because the collection rate for PM(2.5) is typically less frequent than that for ozone.
Extending previous work in Berrocal, Gelfand and Holland (2010), we introduce a bivariate downscaler that provides a flexible class of bivariate space-time assimilation models. We discuss computational issues for model fitting and analyze a dataset for ozone and PM(2.5) for the ozone season during year 2002. We show a modest improvement in predictive performance, not surprising in a setting where we can anticipate only a small gain.
C1 [Berrocal, Veronica J.] Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.
[Gelfand, Alan E.] Duke Univ, Dept Stat Sci, Durham, NC 27708 USA.
[Holland, David M.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Berrocal, VJ (reprint author), Univ Michigan, Dept Biostat, 1415 Washington Hts, Ann Arbor, MI 48109 USA.
EM berrocal@umich.edu; alan@stat.duke.edu; Holland.David@epa.gov
FU NIEHS NIH HHS [R01 ES014843, R01 ES014843-01A2]
NR 53
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U2 12
PU INST MATHEMATICAL STATISTICS
PI CLEVELAND
PA 3163 SOMERSET DR, CLEVELAND, OH 44122 USA
SN 1932-6157
J9 ANN APPL STAT
JI Ann. Appl. Stat.
PD DEC
PY 2010
VL 4
IS 4
BP 1942
EP 1975
DI 10.1214/10-AOAS351
PG 34
WC Statistics & Probability
SC Mathematics
GA 827TK
UT WOS:000295451000021
PM 21853015
ER
PT J
AU Londo, JP
Bautista, NS
Sagers, CL
Lee, EH
Watrud, LS
AF Londo, Jason P.
Bautista, Nonnatus S.
Sagers, Cynthia L.
Lee, E. Henry
Watrud, Lidia S.
TI Glyphosate drift promotes changes in fitness and transgene gene flow in
canola (Brassica napus) and hybrids
SO ANNALS OF BOTANY
LA English
DT Article
DE Gene flow; canola; herbicide drift; transgene escape; plant ecology;
mesocosms; Brassica napus; Brassica rapa
ID OILSEED RAPE; HERBICIDE RESISTANCE; B-RAPA; WILD RELATIVES;
HYBRIDIZATION; INTROGRESSION; EXTINCTION; CROPS; RISK; CONSEQUENCES
AB With the advent of transgenic crops, genetically modified, herbicide-resistant Brassica napus has become a model system for examining the risks and potential ecological consequences of escape of transgenes from cultivation into wild compatible species. Escaped transgenic feral B. napus and hybrids with compatible weedy species have been identified outside of agriculture and without the apparent selection for herbicide resistance. However, herbicide (glyphosate) exposure can extend beyond crop field boundaries, and a drift-level of herbicide could function as a selective agent contributing to increased persistence of transgenes in the environment.
The effects of a drift level (0 center dot 1 x the field application rate) of glyphosate herbicide and varied levels of plant competition were examined on plant fitness-associated traits and gene flow in a simulated field plot, common garden experiment. Plants included transgenic, glyphosate-resistant B. napus, its weedy ancestor B. rapa, and hybrid and advanced generations derived from them.
The results of this experiment demonstrate reductions in reproductive fitness for non-transgenic genotypes and a contrasting increase in plant fitness for transgenic genotypes as a result of glyphosate-drift treatments. Results also suggest that a drift level of glyphosate spray may influence the movement of transgenes among transgenic crops and weeds and alter the processes of hybridization and introgression in non-agronomic habitats by impacting flowering phenology and pollen availability within the community.
The results of this study demonstrate the potential for persistence of glyphosate resistance transgenes in weedy plant communities due to the effect of glyphosate spray drift on plant fitness. Additionally, glyphosate drift has the potential to change the gene-flow dynamics between compatible transgenic crops and weeds, simultaneously reducing direct introgression into weedy species while contributing to an increase in the transgenic seed bank.
C1 [Londo, Jason P.; Bautista, Nonnatus S.] Natl Res Council Associate, Corvallis, OR 97333 USA.
[Bautista, Nonnatus S.] Ateneo Manila Univ, Sch Sci & Engn, Dept Biol, Manila, Philippines.
[Londo, Jason P.; Sagers, Cynthia L.] Univ Arkansas, Dept Biol Sci, SCEN 632, Fayetteville, AR 72701 USA.
[Lee, E. Henry; Watrud, Lidia S.] US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA.
RP Londo, JP (reprint author), Natl Res Council Associate, 200 SW 35th St, Corvallis, OR 97333 USA.
EM jlondo@uark.edu
RI Eclevia, Marian/I-6486-2013
FU US Environmental Protection Agency
FX We would like to acknowledge horticultural and technical support
provided by George King, Milt Plocher, Marjorie Storm, Gail Heine and
Fred Senecal (Dynamac Corporation). The information in this document has
been funded wholly (or in part) by the US Environmental Protection
Agency. It has been subjected to review by the National Health and
Environmental Effects Research Laboratory's Western Ecology Division and
approved for publication. Approval does not signify that the contents
reflect the views of the Agency, nor does mention of trade names or
commercial products constitute endorsement or recommendation for use.
NR 45
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PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0305-7364
J9 ANN BOT-LONDON
JI Ann. Bot.
PD DEC
PY 2010
VL 106
IS 6
BP 957
EP 965
DI 10.1093/aob/mcq190
PG 9
WC Plant Sciences
SC Plant Sciences
GA 685NR
UT WOS:000284635900010
PM 20852306
ER
PT J
AU Wahman, DG
Schrantz, KA
Pressman, JG
AF Wahman, David G.
Schrantz, Karen A.
Pressman, Jonathan G.
TI Determination of the Effects of Medium Composition on the Monochloramine
Disinfection Kinetics of Nitrosomonas europaea by the Propidium
Monoazide Quantitative PCR and Live/Dead BacLight Methods
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID WATER-QUALITY; DRINKING-WATER; INACTIVATION; CHLORINE; EFFICACY
AB Various medium compositions (phosphate, 1 to 50 mM; ionic strength, 2.8 to 150 meq/liter) significantly affected Nitrosomonas europaea monochloramine disinfection kinetics, as determined by the Live/Dead BacLight (LD) and propidium monoazide quantitative PCR (PMA-qPCR) methods (lag coefficient, 37 to 490 [LD] and 91 to 490 [PMA-qPCR] mg center dot min/liter; Chick-Watson rate constant, 4.0 X 10(-3) to 9.3 X 10(-3) [LD] and 1.6 X 10(-3) to 9.6 X 10(-3) [PMA-qPCR] liter/mg center dot min). Two competing effects may account for the variation in disinfection kinetic parameters: (i) increasing kinetics (disinfection rate constant [k] increased, lag coefficient [b] decreased) with increasing phosphate concentration and (ii) decreasing kinetics (k decreased, b increased) with increasing ionic strength. The results support development of a standard medium for evaluating disinfection kinetics in drinking water.
C1 [Wahman, David G.; Schrantz, Karen A.; Pressman, Jonathan G.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
RP Pressman, JG (reprint author), US EPA, Off Res & Dev, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM pressman.jonathan@epa.gov
NR 24
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U2 17
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD DEC
PY 2010
VL 76
IS 24
BP 8277
EP 8280
DI 10.1128/AEM.01631-10
PG 4
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA 688VO
UT WOS:000284882800048
PM 20952645
ER
PT J
AU Johnson, MM
Williams, R
Fan, ZH
Lin, L
Hudgens, E
Gallagher, J
Vette, A
Neas, L
Ozkaynak, H
AF Johnson, Markey M.
Williams, Ron
Fan, Zhihua
Lin, Lin
Hudgens, Edward
Gallagher, Jane
Vette, Alan
Neas, Lucas
Ozkaynak, Haluk
TI Participant-based monitoring of indoor and outdoor nitrogen dioxide,
volatile organic compounds, and polycyclic aromatic hydrocarbons among
MICA-Air households
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Participant based air monitoring; Indoor/outdoor residential monitoring;
Nitrogen dioxide; Volatile organic compounds; Polycyclic aromatic
hydrocarbons; Estimation of short term pollutant concentrations using
integrated site specific measurements and continuous regulatory
monitoring Detroit Michigan
ID NEW-YORK-CITY; RESPIRATORY SYMPTOMS; PARTICULATE MATTER; EXPOSURES;
POLLUTION; CHILDREN; ASTHMA; POLLUTANTS; ROAD; CALIFORNIA
AB The Mechanistic Indicators of Childhood Asthma (MICA) study in Detroit Michigan introduced a participant-based approach to reduce the resource burden associated with collection of indoor and outdoor residential air sampling data A subset of participants designated as MICA-Air conducted indoor and outdoor residential sampling of nitrogen dioxide (NO(2)) volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs) This participant-based methodology was subsequently adapted for use in the Vanguard phase of the US National Children s Study The current paper examines residential indoor and outdoor concentrations of these pollutant species among health study participants in Detroit Michigan
Pollutants measured under MICA-Air agreed well with other studies and continuous monitoring data collected in Detroit For example NO(2) and BTEX concentrations reported for other Detroit area monitoring were generally within 10-15% of indoor and outdoor concentrations measured in MICA-Air households Outdoor NO(2) concentrations were typically higher than indoor NO(2) concentration among MICA-Air homes with a median indoor/outdoor (I/O) ratio of 06 in homes that were not Impacted by environmental tobacco smoke (ETS) during air sampling Indoor concentrations generally exceeded outdoor concentrations for VOC and PAH species measured among non-ETS homes in the study I/O ratios for BTEX species (benzene toluene ethylbenzene and m/p- and o-xylene) ranged from 1 2 for benzene to 3 1 for toluene Outdoor NO(2) concentrations were approximately 4 5 ppb higher on weekdays versus weekends As expected I/O ratios pollutants were generally higher for homes impacted by ETS
These findings suggest that participant-based air sampling can provide a cost-effective alternative to technician-based approaches for assessing Indoor and outdoor residential air pollution in community health studies We also introduced a technique for estimating daily concentrations at each home by weighting 2- and 7-day integrated concentrations using continuous measurements from regulatory monitoring sites This approach may be applied to estimate short-term daily or hourly pollutant concentrations in future health studies (C) 2010 Elsevier Ltd All rights reserved
C1 [Johnson, Markey M.; Hudgens, Edward; Gallagher, Jane; Neas, Lucas] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Johnson, Markey M.; Williams, Ron; Vette, Alan; Ozkaynak, Haluk] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Fan, Zhihua; Lin, Lin] Rutgers State Univ, Univ Med & Dent NJ, Environm & Occupat Hlth Sci Inst, Piscataway, NJ USA.
RP Johnson, MM (reprint author), Hlth Canada, Air Hlth Sci Div, Water Air & Climate Change Bur, 269 Laurier Ave W,Room 3 020A, Ottawa, ON K1A 0K9, Canada.
RI Vette, Alan/A-7330-2012; Neas, Lucas/J-9378-2012
OI Vette, Alan/0000-0001-6749-1252;
FU EPA through Office of Research and Development [CCR 831 625, CR 831
625]; Environmental and Occupational Health Sciences Institute;
University of Medicine and Dentistry of New Jersey - Rutgers University
FX EPA through its Office of Research and Development partially funded and
collaborated in the research described here under contract no CCR 831
625 to Westat and cooperative agreement no CR 831 625 with the
Environmental and Occupational Health Sciences Institute University of
Medicine and Dentistry of New Jersey - Rutgers University It has been
subjected to agency review and approved for publication Approval does
not signify that the contents reflect the views of the agency nor does
mention of trade names or commercial products constitute endorsement or
recommendation for use
NR 47
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U1 0
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD DEC
PY 2010
VL 44
IS 38
BP 4927
EP 4936
DI 10.1016/j.atmosenv.2010.08.027
PG 10
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 682GM
UT WOS:000284389400011
ER
PT J
AU Simon, H
Kimura, Y
McGaughey, G
Allen, DT
Brown, SS
Coffman, D
Dibb, J
Osthoff, HD
Quinn, P
Roberts, JM
Yarwood, G
Kemball-Cook, S
Byun, D
Lee, D
AF Simon, H.
Kimura, Y.
McGaughey, G.
Allen, D. T.
Brown, S. S.
Coffman, D.
Dibb, J.
Osthoff, H. D.
Quinn, P.
Roberts, J. M.
Yarwood, G.
Kemball-Cook, S.
Byun, D.
Lee, D.
TI Modeling heterogeneous ClNO2 formation, chloride availability, and
chlorine cycling in Southeast Texas
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article; Proceedings Paper
CT 2nd Biennial Conference on Atmospheric Chemistry Mechanisms
CY DEC, 2008
CL Air Quality Res Ctr, Davis, CA
HO Air Quality Res Ctr
DE Nitryl chloride; Chlorine; CAMx; Urban air pollution; Houston; GoMACCS;
TexAQS II; Heterogeneous chemistry
ID SEA-SALT AEROSOL; N2O5 REACTION; GASEOUS N2O5; CHEMISTRY; EMISSIONS;
SURFACE; PARAMETERIZATION; PARTICLES; OZONE
AB Nitryl Chloride (ClNO2) mixing ratios above 1 ppbv have been measured off the coast of Southeast Texas ClNO2 formation the result of heterogeneous N2O5 uptake on chloride-containing aerosols has a significant Impact on oxidant formation for the Houston area This work reports on the modeling of ClNO2 formation and describes the sensitivity of ClNO2 formation to key parameters Model sensitivity analyses found that (1) Chloride availability limits the formation of nitryl chloride at ground level but not aloft (2) When excess particulate chloride was assumed to be present at ground level through sea salt ClNO2 concentrations increased in some locations by a factor of 13 as compared to cases where sea salt chloride was assumed to be limited (3) Inland formation of ClNO2 seems feasible based on chloride availability and could have a large impact on total ClNO2 formed in the region and (4) ClNO2 formation is quite sensitive to the assumed yield of ClNO2 from N2O5 uptake These results demonstrate that there is a need for further field studies to better understand the geographic extent of ClNO2 formation and the atmospheric conditions which control partitioning of chloride into the particle phase In addition this work examined the role of ClNO2 in the cycling of chlorine between chloride and reactive chlorine radicals The modeling indicated that the majority of reactive chlorine in Texas along the Gulf coast is cycled through ClNO2 demonstrating the importance of including ClNO2 into photochemical models for this region Published by Elsevier Ltd
C1 [Simon, H.; Kimura, Y.; McGaughey, G.; Allen, D. T.] Univ Texas Austin, Ctr Energy & Environm Resources, Austin, TX 78758 USA.
[Simon, H.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Brown, S. S.; Osthoff, H. D.; Roberts, J. M.] NOAA, ESRL, Div Chem Sci, Boulder, CO 80305 USA.
[Coffman, D.; Quinn, P.] NOAA, OAR, Pacific Marine Environm Lab, Seattle, WA 98115 USA.
[Dibb, J.] Univ New Hampshire, Climate Change Res Ctr, Durham, NH 03824 USA.
[Yarwood, G.; Kemball-Cook, S.] Environ Int Corp, Novato, CA 94998 USA.
[Lee, D.] Univ Houston, Dept Earth & Atmospher Sci, Houston, TX 77204 USA.
[Byun, D.] NOAA, Air Resources Lab, OAR, Silver Spring, MD 20910 USA.
RP Simon, H (reprint author), Univ Texas Austin, Ctr Energy & Environm Resources, 10100 Burnet Rd,Bldg 133,R7100, Austin, TX 78758 USA.
RI simon, heather/E-4392-2011; Roberts, James/A-1082-2009; Brown,
Steven/I-1762-2013; Quinn, Patricia/R-1493-2016; Manager, CSD
Publications/B-2789-2015
OI simon, heather/0000-0001-7254-3360; Roberts, James/0000-0002-8485-8172;
Quinn, Patricia/0000-0003-0337-4895;
NR 32
TC 18
Z9 18
U1 2
U2 36
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
EI 1873-2844
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD DEC
PY 2010
VL 44
IS 40
SI SI
BP 5476
EP 5488
DI 10.1016/j.atmosenv.2009.09.006
PG 13
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 696PA
UT WOS:000285452100018
ER
PT J
AU Daston, GP
Chapin, RE
Scialli, AR
Piersma, AH
Carney, EW
Rogers, JM
Friedman, JM
AF Daston, George P.
Chapin, Robert E.
Scialli, Anthony R.
Piersma, Aldert H.
Carney, Edward W.
Rogers, John M.
Friedman, Jan M.
TI A Different Approach to Validating Screening Assays for Developmental
Toxicity
SO BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY
LA English
DT Article
DE in vitro methods; validation; developmental toxicity
ID VITRO EMBRYOTOXICITY TESTS; IN-VITRO; EMBRYO CULTURE; RAT; PREDICTION;
CHEMICALS; SELECTION; WORKSHOP
AB BACKGROUND: There continue to be many efforts around the world to develop assays that are shorter than the traditional embryofetal developmental toxicity assay, or use fewer or no mammals, or use less compound, or have all three attributes. Each assay developer needs to test the putative assay against a set of performance standards, which traditionally has involved testing the assays against a list of compounds that are generally recognized as "positive'' or "negative'' in vivo. However, developmental toxicity is highly conditional, being particularly dependent on magnitude (i.e. dose) and timing of exposure, which makes it difficult to develop lists of compounds neatly assigned as developmental toxicants or not. APPROACH: Here we offer an alternative approach for the evaluation of developmental toxicity assays based on exposures. Exposures are classified as "positive'' or "negative'' in a system, depending on the compound and the internal concentration. Although this linkage to "internal dose'' departs from the recent approaches to validation, it fits well with widely accepted principles of developmental toxicology. CONCLUSIONS: This paper introduces this concept, discusses some of the benefits and drawbacks of such an approach, and lays out the steps we propose to implement it for the evaluation of developmental toxicity assays. Birth Defects Res (Part B) 89: 526-530, 2010. (C) 2010 Wiley-Liss, Inc.
C1 [Daston, George P.] Procter & Gamble Co, Cincinnati, OH 45202 USA.
[Chapin, Robert E.] Pfizer Global R&D, Groton, CT USA.
[Scialli, Anthony R.] Tetra Tech Sci, Arlington, VA USA.
[Piersma, Aldert H.] RIVM, Bilthoven, Netherlands.
[Carney, Edward W.] Dow Chem Co USA, Midland, MI 48674 USA.
[Rogers, John M.] US EPA, Tox Assessment Div, NHEERL, ORD, Res Triangle Pk, NC 27711 USA.
[Friedman, Jan M.] Univ British Columbia, Dept Med Genet, Vancouver, BC, Canada.
[Friedman, Jan M.] Child & Family Res Inst, Vancouver, BC, Canada.
RP Daston, GP (reprint author), Procter & Gamble Co, Cincinnati, OH 45202 USA.
EM Daston.gp@pg.com
OI Chapin, Robert/0000-0002-5997-1261; Friedman, Jan/0000-0002-7482-9570
NR 15
TC 26
Z9 26
U1 1
U2 3
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1542-9733
J9 BIRTH DEFECTS RES B
JI Birth Defects Res. Part B-Dev. Reprod. Toxicol.
PD DEC
PY 2010
VL 89
IS 6
BP 526
EP 530
DI 10.1002/bdrb.20276
PG 5
WC Oncology; Genetics & Heredity; Toxicology
SC Oncology; Genetics & Heredity; Toxicology
GA 695TX
UT WOS:000285396600008
PM 21086491
ER
PT J
AU Ferraro, SP
Cole, FA
AF Ferraro, Steven P.
Cole, Faith A.
TI Ecological periodic tables for nekton usage of four US Pacific Northwest
estuarine habitats
SO CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES
LA English
DT Article
ID SEAGRASS BEDS; ECOSYSTEM ENGINEERS; SPATIAL-PATTERNS; STABLE STATES;
YAQUINA BAY; SALT-MARSH; FISH; ASSEMBLAGES; ABUNDANCE; IDENTIFICATION
AB We compared the species composition and abundance of the total nekton community, using the Bray-Curtis similarity coefficient, and mean total nekton, fish and crab species richness, abundance and biomass, and shrimp abundance across four intertidal habitats in a US Pacific Northwest estuary: (i) eelgrass (Zostera marina); (ii) burrowing mud shrimp (Upogebia pugettensis); (iii) burrowing ghost shrimp (Neotrypaea californiensis); and (iv) unvegetated sand. Field sampling was conducted during daytime high tides, and was quantitative, stratified-by-habitat, randomized, and estuary-wide. More than 10 000 nekton specimens belonging to 64 taxa were collected in 454 samples during 10 sampling periods, each approximately one-month-long (from June to November), over 3 years (1998-2000). Non-metric multidimensional scaling analyses revealed annually recurring across-habitat patterns in total nekton Bray-Curtis similarity. Two-way (habitat, year) analyses of variance revealed annually recurring across-habitat patterns on 10 indicators of nekton-habitat quality and preference. Total nekton species richness, abundance, and biomass were, respectively, on average, 8 x, 25 x, and 25 x greater in eelgrass, 4 x, 6 x, and 5 x greater in mud shrimp, and 2 x, 3 x, and 2 x greater in ghost shrimp, than in sand habitat. Our findings validate the ecological relevance of our habitats to nekton, and suggest they can serve as elements in ecological periodic tables of nekton habitat usage.
C1 [Ferraro, Steven P.; Cole, Faith A.] US EPA, Hatfield Marine Sci Ctr, Newport, OR 97365 USA.
RP Ferraro, SP (reprint author), US EPA, Hatfield Marine Sci Ctr, 2111 SE Marine Sci Dr, Newport, OR 97365 USA.
EM ferraro.steven@epa.gov
FU US Environmental Protection Agency
FX We thank two anonymous reviewers and the Associate Editor for their
suggestions, M. Elliott, C. Ryer, C. Weilhoefer, and W. Nelson for
reviewing an earlier draft of the manuscript, and K. Chapin, V. Nguyen,
P. Clinton, C. Folger, M. Vance, A. Taylor, S. Courbis, J. Jenson, J.
Sewall, E. Kolkemo, G. Jensen, D. Markle, J. Chapman, J. Power, M.
O'Brien, and K. Ebert for their technical assistance. The information in
this document has been funded wholly by the US Environmental Protection
Agency. It has been subjected to review by the National Health and
Environmental Effects Research Laboratory's Western Ecology Division and
approved for publication. Approval does not signify that the contents
reflect the views of the Agency, nor does mention of trade names or
commercial products constitute endorsement or recommendation for use.
NR 63
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PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 1200 MONTREAL ROAD, BUILDING M-55, OTTAWA, ON K1A 0R6, CANADA
SN 0706-652X
J9 CAN J FISH AQUAT SCI
JI Can. J. Fish. Aquat. Sci.
PD DEC
PY 2010
VL 67
IS 12
BP 1957
EP 1967
DI 10.1139/F10-114
PG 11
WC Fisheries; Marine & Freshwater Biology
SC Fisheries; Marine & Freshwater Biology
GA 697YH
UT WOS:000285555200006
ER
PT J
AU Tong, HY
Cheng, WY
Samet, JM
Gilmour, MI
Devlin, RB
AF Tong, Haiyan
Cheng, Wan-Yun
Samet, James M.
Gilmour, M. Ian
Devlin, Robert B.
TI Differential Cardiopulmonary Effects of Size-Fractionated Ambient
Particulate Matter in Mice
SO CARDIOVASCULAR TOXICOLOGY
LA English
DT Article
DE Coarse PM; Fine PM; Ultrafine PM; Cardiopulmonary effects; Cardiac
ischemia/reperfusion injury
ID AIR-POLLUTION; ULTRAFINE PARTICLES; CARDIAC CHANGES; EXPOSURE;
INHALATION; HEALTHY; TOXICITY; ISCHEMIA; INJURY; FINE
AB A growing body of evidence from epidemiological and toxicological studies provides a strong link between exposure to ambient particulate matter (PM) of varying size and increased cardiovascular and respiratory morbidity and mortality. This study was designed to evaluate the cardiopulmonary effects of ambient coarse, fine, and ultrafine particles collected in Chapel Hill, NC. Mice were exposed to each size fraction by oropharyngeal instillation. Twenty-four hours later, pulmonary inflammation was assessed by bronchoalveolar lavage and cardiac injury was measured using a Langendorff cardiac perfusion preparation. Recovery of post-ischemic left ventricular developed pressure and infarct size were measured as indeces of cardiac ischemia/reperfusion injury. Coronary flow rate was measured before, during, and after ischemia. We demonstrate that coarse PM caused the most significant pulmonary inflammatory responses. In contrast, hearts from ultrafine-exposed mice had significantly lower post-ischemic functional recovery and greater infarct size, while hearts from coarse and fine PM-exposed mice had no significant responses to ischemia/reperfusion. The coronary flow rate was significantly reduced in the ultrafine PM group. This study shows that exposure of mice to coarse PM results in significant pulmonary toxicity while ultrafine PM appears to enhance cardiac ischemia/reperfusion injury.
C1 [Tong, Haiyan; Samet, James M.; Gilmour, M. Ian; Devlin, Robert B.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Cheng, Wan-Yun] Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC 27514 USA.
RP Tong, HY (reprint author), US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
EM tong.haiyan@epa.gov
NR 37
TC 38
Z9 40
U1 1
U2 7
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1530-7905
J9 CARDIOVASC TOXICOL
JI Cardiovasc. Toxicol.
PD DEC
PY 2010
VL 10
IS 4
BP 259
EP 267
DI 10.1007/s12012-010-9082-y
PG 9
WC Cardiac & Cardiovascular Systems; Toxicology
SC Cardiovascular System & Cardiology; Toxicology
GA 682RN
UT WOS:000284420800004
PM 20602262
ER
PT J
AU Blanco, I
Beritze, N
Arguelles, M
Carcaba, V
Fernandez, F
Janciauskiene, S
Oikonomopoulou, K
de Serres, FJ
Fernandez-Bustillo, E
Hollenberg, MD
AF Blanco, Ignacio
Beritze, Nana
Argueelles, Mario
Carcaba, Victoriano
Fernandez, Fernando
Janciauskiene, Sabina
Oikonomopoulou, Katerina
de Serres, Frederick J.
Fernandez-Bustillo, Enrique
Hollenberg, Morley D.
TI Abnormal overexpression of mastocytes in skin biopsies of fibromyalgia
patients
SO CLINICAL RHEUMATOLOGY
LA English
DT Article
DE Alpha 1-antitrypsin; Fibromyalgia; Mast cell; Skin biopsy; Tryptase
ID HUMAN MAST-CELLS; ALPHA-1-ANTITRYPSIN; CLASSIFICATION; CRITERIA;
DEFICIENCY; DIAGNOSIS; IGG
AB Formalin-fixed, paraffin-embedded skin tissue sections were collected from a matched cohort of 63 fibromyalgia syndrome (FMS) patients and 49 volunteers from the general population with both alpha1-antitrypsin (AAT) normal and deficiency variants. These tissues were examined for the expression of the broad-spectrum inhibitor AAT, the serine proteinases elastase and tryptase, the proinflammatory cytokines MCP-1 and TNF alpha, the endothelium biomarker VEGF, and the inflammation/nociception-related receptor PAR(2). The most relevant finding of the study was a significantly increased number of mast cells (MCs) in the papillary dermis of all FMS patients (greater than or equal to five to 14 per microscopic high power field) compared to zero to one in controls (p<0.001). MCs strongly stained with tryptase, AAT and PAR(2) antibodies, exhibited a spindle-like shape and were uniformly distributed around blood vessels and appendages. MCP-1 and VEGF expressed weak/moderate positivity in most samples, with a higher expression in controls than in FMS patients (p<0.001 and 0.051, respectively). No differences in elastase and TNF alpha were found between both groups. Moreover, no histological differences were found between samples from AAT deficiency and normal AAT phenotypes. Our results indicate that FMS is a MC-associated condition. MCs are present in skin and mucosal surfaces throughout the human body, and are easily stimulated by a number of physical, psychological, and chemical triggers to degranulate, releasing several proinflammatory products which are able to generate nervous peripheral stimuli causing CNS hypersensitivity, local, and systemic symptoms. Our findings open new avenues of research on FMS mechanisms and will benefit the diagnosis of patients and the development of therapeutics.
C1 [Blanco, Ignacio; Carcaba, Victoriano] Valle Nalon Hosp, Dept Internal Med, Sama De Langreo 33920, Principado Astu, Spain.
[Beritze, Nana; Argueelles, Mario] Cabuenes Hosp, Dept Pathol, Gijon, Principado Astu, Spain.
[Fernandez, Fernando] Valle Nalon Hosp, Dept Surg, Sama De Langreo 33920, Principado Astu, Spain.
[Janciauskiene, Sabina] Hannover Med Sch, Dept Resp Med, D-30625 Hannover, Germany.
[Oikonomopoulou, Katerina] Univ Calgary, Dept Physiol & Pharmacol, Calgary, AB, Canada.
[Oikonomopoulou, Katerina] Univ Calgary, Dept Med, Calgary, AB, Canada.
[de Serres, Frederick J.] Ctr Evaluat Risks Human Reprod, Natl Inst Environm Hlth Sci, MD EC32, Res Triangle Pk, NC 27709 USA.
[Fernandez-Bustillo, Enrique] Cent Univ Hosp Asturias, Biostat Unit, Oviedo 33006, Principado Astu, Spain.
[Hollenberg, Morley D.] Med Univ Calgary, Fac Med Calgary, Dept Physiol & Pharmacol, Calgary, AB T2N 4N1, Canada.
RP Blanco, I (reprint author), Valle Nalon Hosp, Dept Internal Med, Sama De Langreo 33920, Principado Astu, Spain.
EM ignablanco@yahoo.com; nanarus@terra.es;
mario.arguelles@sespa.princast.es; victoriano.carcaba@sespa.princast.es;
frfernando@telecable.es; SabinaJanciauskiene@gmail.com;
oikoa@mail.med.upenn.edu; deserres@bellsouth.net; efbustillo@hca.es;
mhollenb@ucalgary.ca
OI Blanco, Ignacio/0000-0002-7414-7481
FU Alberta Heritage Foundation for Medical Research (AHFMR); Canadian
Institutes of Health Research
FX We would like to thank every patient and volunteer who participated in
this study, providing us with their clinical data and biopsy samples. We
also acknowledge the technical work for the preparation of the
paraffin-embedded tissues samples by Dr. Francisco Dominguez and
laboratory technicians at the Valle del Nalon Hospital, Asturias, Spain;
and the immunohistochemical work performed by Ms. Mercedes Acha
(Cabuenes Hospital, Gijon, Spain). Furthermore, we are indebted to Dr.
Eleftherios P. Diamandis (Mount Sinai Hospital, Toronto) for sharing
vital reagents and ideas for the completion of this work. Finally, we
are grateful to Ms. Jimena Blanco Fueyo (UNESCO; MA/BA Universite de
Geneve) for the English editing of this manuscript. This study has been
endorsed by the Spanish National Health Institute Carlos III and the
Biohealth Research Office (OIB) of the Principado de Asturias, Spain (IB
and VC). KO is a recipient of an Alberta Heritage Foundation for Medical
Research (AHFMR) Postdoctoral Fellowship for whom operating funds were
provided by a grant to MDH by the Canadian Institutes of Health
Research.
NR 27
TC 42
Z9 42
U1 0
U2 2
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 0770-3198
EI 1434-9949
J9 CLIN RHEUMATOL
JI Clin. Rheumatol.
PD DEC
PY 2010
VL 29
IS 12
BP 1403
EP 1412
DI 10.1007/s10067-010-1474-7
PG 10
WC Rheumatology
SC Rheumatology
GA 684KA
UT WOS:000284547600010
PM 20428906
ER
PT J
AU John, RP
Tyagi, RD
Prevost, D
Brar, SK
Pouleur, S
Surampalli, RY
AF John, Rojan P.
Tyagi, R. D.
Prevost, D.
Brar, Satinder K.
Pouleur, Stephan
Surampalli, R. Y.
TI Mycoparasitic Trichoderma viride as a biocontrol agent against Fusarium
oxysporum f. sp adzuki and Pythium arrhenomanes and as a growth promoter
of soybean
SO CROP PROTECTION
LA English
DT Article
DE Trichoderma viride; Soybean; Biocontrol agent; Fusarium oxysporum f. sp
adzuki; Pythium arrhenomanes; Growth promoter
ID LYTIC ENZYMES; HARZIANUM; FERMENTATION; EXPRESSION; SOLANI
AB Trichoderma viride was proved as an effective biocontrol agent against two fungal pathogens, Fusarium oxysporum f. sp. adzuki and Pythium arrhenomanes, infecting soybean. During an in vitro biocontrol test, Trichoderma showed mycoparasitism and destructive control against the tested fungal pathogens. Both the pathogens significantly influence the germination and P. arrhenomanes had a severe effect (only 5% germination). The root system of the soybean plant was poorly developed due to the infection and it exerted a negative influence on the nodulation and further growth phases of the plant. During pot assay along with biocontrol activity, Trichoderma showed growth promoting action on the soybean plant. Trichoderma enhanced growth of shoot and root systems and fruit yield after 12 weeks of growth. Pythium and Fusarium infected plants treated with Trichoderma had similar to 194% and 141% more height than pathogens alone. The fruit yield treated with Trichoderma was similar to 66 per plant whereas the yield was only 41 for a control plant. The plants infected with Pythium and Fusarium and treated with Trichoderma had fruit yields of 43 and 53 respectively and those were 5 and 1.6 times higher than plants infected with pathogens. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [John, Rojan P.; Tyagi, R. D.; Brar, Satinder K.] Univ Quebec, INRS ETE, Quebec City, PQ G1K 9A9, Canada.
[Prevost, D.; Pouleur, Stephan] Agr & Agroalimentaire Canada, Quebec City, PQ GIV 2J3, Canada.
[Surampalli, R. Y.] US EPA, Kansas City, KS 66117 USA.
RP Tyagi, RD (reprint author), Univ Quebec, INRS ETE, 490 Rue Couronne, Quebec City, PQ G1K 9A9, Canada.
EM tyagi@ete.inrs.ca
RI Pappy John, Rojan/C-6571-2009;
OI P. John, Rojan/0000-0002-9703-1238
FU Natural Sciences and Engineering Research Council of Canada (Canada
Research Chair) [A4984]; MAPAQ [807150]; INRS-ETE; FQRNT, Quebec, Canada
FX The authors are sincerely thankful to the Natural Sciences and
Engineering Research Council of Canada (Grants A4984, Canada Research
Chair), MAPAQ (807150), INRS-ETE for financial support. One of the
authors. RPJ, is sincerely thankful to The Quebec fund for research on
nature and technology (FQRNT, Quebec, Canada), for the postdoctoral
fellowship under the programme "Scholarship Programs of excellence for
foreign students". Authors are thankful to Mr. Amine for his help in
statistical analysis and Ms. Carole for her help in phytotron study.
NR 19
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U1 0
U2 22
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0261-2194
J9 CROP PROT
JI Crop Prot.
PD DEC
PY 2010
VL 29
IS 12
BP 1452
EP 1459
DI 10.1016/j.cropro.2010.08.004
PG 8
WC Agronomy
SC Agriculture
GA 682ZY
UT WOS:000284442700012
ER
PT J
AU Mazur, CS
Kenneke, JF
Hess-Wilson, JK
Lipscomb, JC
AF Mazur, Christopher S.
Kenneke, John F.
Hess-Wilson, Janet K.
Lipscomb, John C.
TI Differences between Human and Rat Intestinal and Hepatic Bisphenol A
Glucuronidation and the Influence of Alamethicin on In Vitro Kinetic
Measurements
SO DRUG METABOLISM AND DISPOSITION
LA English
DT Article
ID HUMAN LIVER-MICROSOMES; UDP-GLUCURONOSYLTRANSFERASE; DRUG CLEARANCE;
INTRINSIC CLEARANCE; PROTEIN-BINDING; METABOLISM; PREDICTION;
HEPATOCYTES; EXTRAPOLATION; ABSORPTION
AB The extent to which membrane-disrupting agents, such as alamethicin, may alter cofactor transport and influence in vitro kinetic measurements of glucuronidation is a major concern regarding the characterization and extrapolation of inter-and intraspecies pharmacokinetics of bisphenol A (BPA). An additional concern is the omission of a BPA intestinal metabolism component in current pharmacokinetic models used to assess oral exposure. In this study, BPA glucuronidation in native hepatic microsomes from female rat and female human liver displayed higher V(max) values than that in males. In the presence of alamethicin, all hepatic V(max) values increased; however, this increase was disproportionately greater in males and gender differences were no longer observed. Female rats exhibited a much higher K(m) than all other species and genders; the addition of alamethicin had little influence on K(m) values for any of the test systems. The dissimilar K(m) measured for female rat suggests that different UDP-glucuronosyltransferase (UGT) enzyme(s) are involved in BPA glucuronidation. The presence of different UGTs in female rat was confirmed using Hill coefficients measured from diclofenac-mediated chemical inhibition assays within hepatic microsomes and purified human UGT2B7 and UGT2B15. Mixed-gender human intestinal microsomes showed little BPA glucuronidation reactivity compared with those from male rat intestine. Male rat intestinal microsomes in the presence of alamethicin exhibited a V(max) that was nearly 30-fold higher than that for mixed human microsomes. The species and gender metabolic differences we observed between rat and human liver and intestine provide key information for delineating BPA pharmacokinetics needed for human health risk assessment.
C1 [Mazur, Christopher S.; Kenneke, John F.] US EPA, Natl Exposure Res Lab, Ecosyst Res Div, Athens, GA 30605 USA.
[Hess-Wilson, Janet K.; Lipscomb, John C.] US EPA, Natl Ctr Environm Assessment, Cincinnati, OH 45268 USA.
RP Mazur, CS (reprint author), US EPA, Natl Exposure Res Lab, Ecosyst Res Div, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM mazur.chris@epa.gov
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U2 7
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0090-9556
J9 DRUG METAB DISPOS
JI Drug Metab. Dispos.
PD DEC
PY 2010
VL 38
IS 12
BP 2232
EP 2238
DI 10.1124/dmd.110.034819
PG 7
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 681KB
UT WOS:000284309900021
PM 20736320
ER
PT J
AU Clark, CM
Tilman, D
AF Clark, Christopher M.
Tilman, David
TI Recovery of plant diversity following N cessation: effects of
recruitment, litter, and elevated N cycling
SO ECOLOGY
LA English
DT Article
DE carbon addition; diversity; grassland; invasion; litter inhibition;
nitrogen deposition; prairie restoration; recovery; recruitment
limitation
ID SPECIES-RICH GRASSLANDS; OLD-FIELD SUCCESSION; NITROGEN DEPOSITION;
COMMUNITY STRUCTURE; WESTERN-AUSTRALIA; SEEDLING ESTABLISHMENT;
SECONDARY SUCCESSION; SHORTGRASS STEPPE; RESTORATION; LIMITATION
AB Plant species richness has declined and composition shifted in response to elevated atmospheric deposition of biologically active nitrogen over much of the industrialized world. Litter thickness, litter nitrogen (N) content, and soil N mineralization rates often remain elevated long after inputs cease, clouding the prospects that plant community diversity and composition would recover should N inputs be reduced. Here we determined how N cycling, litter accumulation, and recruitment limitation influenced community recovery following cessation of long-term N inputs to prairie-like grasslands. We alleviated each of these potential inhibitors through a two-year full-factorial experiment involving organic carbon addition, litter removal, and seed addition. Seed addition had the largest effect on increasing seedling and species numbers and may be necessary to overcome long-term burial of seeds of target perennial grassland species. Litter removal increased light availability and bare sites for colonization, though it had little effect on reducing the biomass of competing neighbors or altering extractable soil N. Nonetheless, these positive influences were enough to lead to small increases in species richness within one year. We found that, although C addition quickly altered many factors assumed favorable for the target community (decreased N availability and biomass of nearby competitors, increased light and site availability), these changes were insufficient to positively impact species richness or seedling numbers over the experimental duration. However, only carbon addition had species-specific effects on the existing plant community, suggesting that its apparent limited utility may be more a result of slow recovery under ambient recruitment rather than from a lack of a restorative effect. There were dramatic interactions among treatments, with the positive effects of litter removal largely negated by carbon addition, and the positive effects of seed addition generally amplified by litter removal. It remains unclear whether each mechanism explored here will induce community recovery, but over different temporal scales. Long-term monitoring will help resolve these remaining questions. Regardless, our results suggest that reversal of species loss and compositional shifts from N deposition in prairies may be more inhibited by habitat fragmentation, recruitment limitation, and long-term suppression of fire than from continued effects of elevated N.
C1 [Clark, Christopher M.; Tilman, David] Univ Minnesota, Dept Ecol Evolut & Behav, St Paul, MN 55108 USA.
RP Clark, CM (reprint author), US EPA, Natl Ctr Environm Assessment, Global Change Res Grp, 8601-P,1200 Penn Ave, Washington, DC 20460 USA.
EM Chris.Michael.Clark@gmail.com
FU NSF/DEB [0080382]
FX We thank Troy Mielke, Peter Hawthorn, and many Cedar Creek interns for
their field help, William Eddy for laboratory assistance, and NSF/DEB
0080382 for the supporting this Long-Term Ecological Research project at
Cedar Creek.
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PU ECOLOGICAL SOC AMER
PI WASHINGTON
PA 1990 M STREET NW, STE 700, WASHINGTON, DC 20036 USA
SN 0012-9658
J9 ECOLOGY
JI Ecology
PD DEC
PY 2010
VL 91
IS 12
BP 3620
EP 3630
DI 10.1890/09-1268.1
PG 11
WC Ecology
SC Environmental Sciences & Ecology
GA 699AA
UT WOS:000285635100023
PM 21302833
ER
PT J
AU Stewart, JC
Chalupa, DC
Devlin, RB
Frasier, LM
Huang, LS
Little, EL
Lee, SM
Phipps, RP
Pietropaoli, AP
Taubman, MB
Utell, MJ
Frampton, MW
AF Stewart, Judith C.
Chalupa, David C.
Devlin, Robert B.
Frasier, Lauren M.
Huang, Li-Shan
Little, Erika L.
Lee, Steven M.
Phipps, Richard P.
Pietropaoli, Anthony P.
Taubman, Mark B.
Utell, Mark J.
Frampton, Mark W.
TI Vascular Effects of Ultrafine Particles in Persons with Type 2 Diabetes
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE air pollution; diabetes; platelets; ultrafine particles; vascular
ID VON-WILLEBRAND-FACTOR; DIESEL-EXHAUST INHALATION; PARTICULATE
AIR-POLLUTION; ACUTE CORONARY SYNDROMES; HEALTHY-HUMAN SUBJECTS;
CARDIOVASCULAR-DISEASE; CD40 LIGAND; ENDOTHELIAL-CELLS; TISSUE FACTOR;
MYOCARDIAL-INFARCTION
AB BACKGROUND: Diabetes confers an increased risk for cardiovascular effects of airborne particles.
OBJECTIVE: We hypothesized that inhalation of elemental carbon ultrafine particles (UFP) would activate blood platelets and vascular endothelium in people with type 2 diabetes.
METHODS: In a randomized, double-blind, crossover trial, 19 subjects with type 2 diabetes inhaled filtered air or 50 mu g/m(3) elemental carbon UFP (count median diameter, 32 nm) by mouthpiece for 2 hr at rest. We repeatedly measured markers of vascular activation, coagulation, and systemic inflammation before and after exposure.
RESULTS: Compared with air, particle exposure increased platelet expression of CD40 ligand (CD40L) and the number of platelet-leukocyte conjugates 3.5 hr after exposure. Soluble CD40L decreased with UFP exposure. Plasma von Willebrand factor increased immediately after exposure. There were no effects of particles on plasma tissue factor, coagulation factors VII or IX, or D-dimer.
CONCLUSIONS: Inhalation of elemental carbon UFP for 2-hr transiently activated platelets, and possibly the vascular endothelium, in people with type 2 diabetes.
C1 [Stewart, Judith C.; Chalupa, David C.; Frasier, Lauren M.; Little, Erika L.; Lee, Steven M.; Pietropaoli, Anthony P.; Taubman, Mark B.; Utell, Mark J.; Frampton, Mark W.] Univ Rochester, Med Ctr, Dept Med, Rochester, NY 14642 USA.
[Devlin, Robert B.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Huang, Li-Shan] Univ Rochester, Med Ctr, Dept Biostat & Computat Biol, Rochester, NY 14642 USA.
[Phipps, Richard P.; Utell, Mark J.; Frampton, Mark W.] Univ Rochester, Med Ctr, Dept Environm Med, Rochester, NY 14642 USA.
RP Frampton, MW (reprint author), Univ Rochester, Med Ctr, Dept Med, 601 Elmwood Ave,Box 692, Rochester, NY 14642 USA.
EM mark_frampton@urmc.rochester.edu
FU U.S. Environmental Protection Agency [RD832415]; National Institutes of
Health [RC1 ES018519, RO1 ES017428, R01 ES013394, P30 ES01247, UL1
RR024160, RO1 HL078603]
FX This research was funded wholly or in part by a grant from the U.S.
Environmental Protection Agency through the Science to Achieve Results
(STAR) program (RD832415) to the University of Rochester and by grants
from the National Institutes of Health (RC1 ES018519, RO1 ES017428, R01
ES013394, P30 ES01247, UL1 RR024160, and RO1 HL078603).
NR 58
TC 25
Z9 28
U1 0
U2 14
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD DEC
PY 2010
VL 118
IS 12
BP 1692
EP 1698
DI 10.1289/ehp.1002237
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 692YB
UT WOS:000285190700022
PM 20822968
ER
PT J
AU Reif, DM
Martin, MT
Tan, SW
Houck, KA
Judson, RS
Richard, AM
Knudsen, TB
Dix, DJ
Kavlock, RJ
AF Reif, David M.
Martin, Matthew T.
Tan, Shirlee W.
Houck, Keith A.
Judson, Richard S.
Richard, Ann M.
Knudsen, Thomas B.
Dix, David J.
Kavlock, Robert J.
TI Endocrine Profiling and Prioritization of Environmental Chemicals Using
ToxCast Data
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE androgen; chemical prioritization; data integration; endocrine
disruption; estrogen; screening; ToxCast; toxicity profile; ToxPi
ID REPRODUCTIVE TOXICITY; ESTROGEN-RECEPTOR; BISPHENOL-A; MALE RATS;
IN-VITRO; MODE; ANTIANDROGENS; PROGRAM; LINURON; GENES
AB BACKGROUND: The prioritization of chemicals for toxicity testing is a primary goal of the U. S. Environmental Protection Agency (EPA) ToxCast (TM) program. Phase I of ToxCast used a battery of 467 in vitro, high-throughput screening assays to assess 309 environmental chemicals. One important mode of action leading to toxicity is endocrine disruption, and the U. S. EPA's Endocrine Disruptor Screening Program (EDSP) has been charged with screening pesticide chemicals and environmental contaminants for their potential to affect the endocrine systems of humans and wildlife.
OBJECTIVE: The goal of this study was to develop a flexible method to facilitate the rational prioritization of chemicals for further evaluation and demonstrate its application as a candidate decision-support tool for EDSP.
METHODS: Focusing on estrogen, androgen, and thyroid pathways, we defined putative endocrine profiles and derived a relative rank or score for the entire ToxCast library of 309 unique chemicals. Effects on other nuclear receptors and xenobiotic metabolizing enzymes were also considered, as were pertinent chemical descriptors and pathways relevant to endocrine-mediated signaling.
RESULTS: Combining multiple data sources into an overall, weight-of-evidence Toxicological Priority Index (ToxPi) score for prioritizing further chemical testing resulted in more robust conclusions than any single data source taken alone.
CONCLUSIONS: Incorporating data from in vitro assays, chemical descriptors, and biological pathways in this prioritization schema provided a flexible, comprehensive visualization and ranking of each chemical's potential endocrine activity. Importantly, ToxPi profiles provide a transparent visualization of the relative contribution of all information sources to an overall priority ranking. The method developed here is readily adaptable to diverse chemical prioritization tasks.
C1 [Reif, David M.; Martin, Matthew T.; Houck, Keith A.; Judson, Richard S.; Richard, Ann M.; Knudsen, Thomas B.; Dix, David J.; Kavlock, Robert J.] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Tan, Shirlee W.] US EPA, Off Sci Coordinat & Policy, Off Pollut Prevent Pesticides & Tox Subst, Res Triangle Pk, NC 27711 USA.
RP Reif, DM (reprint author), US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Mail Drop B-205-01, Res Triangle Pk, NC 27711 USA.
EM reif.david@epa.gov
RI Martin, Matthew/A-1982-2013;
OI Martin, Matthew/0000-0002-8096-9908; Reif, David/0000-0001-7815-6767
NR 36
TC 86
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U1 7
U2 36
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD DEC
PY 2010
VL 118
IS 12
BP 1714
EP 1720
DI 10.1289/ehp.1002180
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 692YB
UT WOS:000285190700025
PM 20826373
ER
PT J
AU Backus, GS
Howden, R
Fostel, J
Bauer, AK
Cho, HY
Marzec, J
Peden, DB
Kleeberger, SR
AF Backus, Gillian S.
Howden, Reuben
Fostel, Jennifer
Bauer, Alison K.
Cho, Hye-Youn
Marzec, Jacqui
Peden, David B.
Kleeberger, Steven R.
TI Protective Role of Interleukin-10 in Ozone-Induced Pulmonary
Inflammation
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE air pollution; gene array; IL-10; inflammation; lung; ozone; pulmonary
ID NITRIC-OXIDE SYNTHASE; TUMOR-NECROSIS-FACTOR; INDUCED LUNG INFLAMMATION;
GENE-EXPRESSION; FACTOR-ALPHA; KAPPA-B; COSTIMULATORY MOLECULES;
ALVEOLAR MACROPHAGES; CYTOKINE SIGNALING-3; AIRWAY INFLAMMATION
AB BACKGROUND: The mechanisms underlying ozone (O(3))-induced pulmonary inflammation remain unclear. Interleukin-10 (IL-10) is an anti-inflammatory cytokine that is known to inhibit inflammatory mediators.
OBJECTIVES: We investigated the molecular mechanisms underlying interleuken-10 (IL-10)-mediated attenuation of O(3)-induced pulmonary inflammation in mice.
METHODS: Il10-deficient (Il10(-/-)) and wild-type (Il10(+/+)) mice were exposed to 0.3 ppm O(3) or filtered air for 24, 48, or 72 hr. Immediately after exposure, differential cell counts and total protein (a marker of lung permeability) were assessed from bronchoalveolar lavage fluid (BALF). mRNA and protein levels of cellular mediators were determined from lung homogenates. We also used global mRNA expression analyses of lung tissue with Ingenuity Pathway Analysis to identify patterns of gene expression through which IL-10 modifies O(3)-induced inflammation.
RESULTS: Mean numbers of BALF polymorphonuclear leukocytes (PMNs) were significantly greater in Il10(-/-) mice than in Il10(+/+) mice after exposure to O(3) at all time points tested. O(3)-enhanced nuclear NF-kappa B translocation was elevated in the lungs of Il10(-/-) compared with Il10(+/+) mice. Gene expression analyses revealed several IL-10-dependent and O(3)-dependent mediators, including macro-phage inflammatory protein 2, cathepsin E, and serum amyloid A3.
CONCLUSIONS: Results indicate that IL-10 protects against O(3)-induced pulmonary neutrophilic inflammation and cell proliferation. Moreover, gene expression analyses identified three response pathways and several genetic targets through which IL-10 may modulate the innate and adaptive immune response. These novel mechanisms of protection against the pathogenesis of O(3)-induced pulmonary inflammation may also provide potential therapeutic targets to protect susceptible individuals.
C1 [Backus, Gillian S.; Fostel, Jennifer; Cho, Hye-Youn; Marzec, Jacqui; Kleeberger, Steven R.] Natl Inst Environm Hlth Sci, Lab Resp Biol, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA.
[Howden, Reuben] Univ N Carolina, Dept Kinesiol, Charlotte, NC 28223 USA.
[Bauer, Alison K.] Michigan State Univ, Dept Pathobiol & Diagnost Invest, Ctr Integrat Toxicol, E Lansing, MI 48824 USA.
[Peden, David B.] Univ N Carolina, Sch Med, Dept Pediat, Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC USA.
[Peden, David B.] Univ N Carolina, Sch Med, Div Immunol & Infect Dis, Chapel Hill, NC USA.
RP Kleeberger, SR (reprint author), Natl Inst Environm Hlth Sci, Lab Resp Biol, NIH, Dept Hlth & Human Serv, 111 TW Alexander Dr,Bldg 101,MD 201, Res Triangle Pk, NC 27709 USA.
EM kleeber1@niehs.nih.gov
FU Division of Intramural Research, National Institute of Environmental
Health Sciences (NIEHS), National Institutes of Health, Department of
Health and Human Services; NIEHS [R01ES012706]
FX This work was supported by the Division of Intramural Research, National
Institute of Environmental Health Sciences (NIEHS), National Institutes
of Health, Department of Health and Human Services. D.B.P. was supported
by a grant from NIEHS (R01ES012706).
NR 48
TC 22
Z9 22
U1 0
U2 1
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD DEC
PY 2010
VL 118
IS 12
BP 1721
EP 1727
DI 10.1289/ehp.1002182
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 692YB
UT WOS:000285190700026
PM 20826374
ER
PT J
AU Weber, MA
Tidwell, VC
Thacher, JA
AF Weber, Matthew A.
Tidwell, Vincent C.
Thacher, Jennifer A.
TI Dynamic physical and economic modelling of riparian restoration options
SO ENVIRONMENTAL MODELLING & SOFTWARE
LA English
DT Article
DE Dynamic simulation; River restoration; Benefit-cost analysis; Ecosystem
service; Adaptive management; Choice experiment; Rio Grande
ID CONTINGENT VALUATION; ECOSYSTEM SERVICES; DECISION-MAKING;
UNITED-STATES; LAND-USE; RESOURCES; MANAGEMENT; IMPROVEMENTS;
METAANALYSIS; SUPPORT
AB A dynamic simulation framework is used to compare benefit-cost ratios of riparian restoration investment strategies to pursue ecosystem service benefits. The model is meant to be adaptable to generic restoration planning applications, with the Middle Rio Grande riparian corridor in Albuquerque, New Mexico, U.S.A. presented here as the illustrating case. Model inputs include ecosystem service values from an original choice experiment, values from regional benefit transfer studies, and information from land managers.
The model includes three control variable modules: forest management, river restoration, and recreation infrastructure. Investment influences these modules, which in turn affect ecosystem service flows for the region. The model is exercised to compare a "No-Action" alternative with "Optimal Benefit-Cost Ratio" restoration funding. An extended sensitivity analysis explores a range of both physical and economic assumptions. The analysis has two major outcomes. The first is that directed restoration funding yields significant gains as compared with No-Action for all scenarios tested. The second major finding is that although optimized benefit-cost ratios are above unity for all "states of the world" tested, the ratio itself and funding patterns varied widely. These sensitivities underscore the need for a transparent adaptive management decision process supported by tools aimed not at deterministic prediction, but rather at structuring dialogue and inquiry into issues that defy simple intuition. Published by Elsevier Ltd.
C1 [Weber, Matthew A.] Univ Arizona, Dept Hydrol & Water Resources, Tucson, AZ 85721 USA.
[Tidwell, Vincent C.] Sandia Natl Labs, Geohydrol Dept 6313, Albuquerque, NM 87185 USA.
[Thacher, Jennifer A.] 1 Univ New Mexico, Dept Econ, Albuquerque, NM 87131 USA.
RP Weber, MA (reprint author), US EPA, 200 SW 35th St, Corvallis, OR 97333 USA.
EM weber.matthew@epa.gov; vctidwe@sandia.gov; jthacher@unm.edu
RI Thacher, Jennifer /F-5035-2012
FU Sustainability of semi-Arid Hydrology and Riparian Areas (a National
Science Foundation Science and Technology Center); Sandia National
Laboratories for their support through a Campus Executive Laboratory
Directed Research and Development (LDRD)
FX We thank the institutional and financial support of Sustainability of
semi-Arid Hydrology and Riparian Areas (a National Science Foundation
Science and Technology Center). We further thank Sandia National
Laboratories for their support through a Campus Executive Laboratory
Directed Research and Development (LDRD) fellowship. We thank Ondrea
Hummel (U.S. Army Corps of Engineers, Albuquerque District) for her
biology modelling and restoration cost advice, but note no
responsibility of the Corps in association with this work should be
thereby implied. We thank Connie Burdick of the U.S. Environmental
Protection Agency for her GIS and graphics assistance. The authors are
solely responsible for any errors.
NR 48
TC 1
Z9 1
U1 2
U2 22
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1364-8152
J9 ENVIRON MODELL SOFTW
JI Environ. Modell. Softw.
PD DEC
PY 2010
VL 25
IS 12
BP 1825
EP 1836
DI 10.1016/j.envsoft.2010.05.017
PG 12
WC Computer Science, Interdisciplinary Applications; Engineering,
Environmental; Environmental Sciences
SC Computer Science; Engineering; Environmental Sciences & Ecology
GA 660PI
UT WOS:000282655200031
ER
PT J
AU Smith, LM
Nestlerode, JA
Harwell, LC
Bourgeois, P
AF Smith, Lisa M.
Nestlerode, Janet A.
Harwell, Linda C.
Bourgeois, Pete
TI The areal extent of brown shrimp habitat suitability in Mobile Bay,
Alabama, USA: targeting vegetated habitat restoration
SO ENVIRONMENTAL MONITORING AND ASSESSMENT
LA English
DT Article
DE Brown shrimp; Estuarine habitat; Habitat suitability index (HSI); Gulf
of Mexico; Mobile Bay
ID PENAEUS-AZTECUS; FARFANTEPENAEUS-AZTECUS; GALVESTON BAY; POSTLARVAL;
SELECTION; MODEL
AB The availability of wetlands and shallow water habitats significantly influences Gulf of Mexico (GOM) penaeid shrimp fishery productivity. However, the GOM region has the highest rate of wetland loss in the USA. Protection and management of these vital GOM habitats are critical to sustainable shrimp fisheries. Brown shrimp (Farfantepenaeus aztecus) are a major component of GOM fisheries. We present an approach for estimating the areal extent of suitable habitat for post-larval and juvenile brown shrimp in Mobile Bay, Alabama, using an existing habitat suitability index model for the northern GOM calculated from probabilistic survey of water quality and sediment data, land cover data, and submerged aquatic vegetation coverages. This estuarine scale approach is intended to support targeted protection and restoration of these habitats. These analyses indicate that approximately 60% of the area of Mobile Bay is categorized as suitable to near optimal for post-larval and juvenile shrimp and 38% of the area is marginally to minimally suitable. We identify potential units within Mobile Bay for targeted restoration to improve habitat suitability.
C1 [Smith, Lisa M.; Nestlerode, Janet A.; Harwell, Linda C.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Lab, Gulf Breeze, FL 32561 USA.
[Bourgeois, Pete] US Geol Survey, Natl Wetlands Res Ctr, Gulf Breeze Field Off, Gulf Breeze, FL 32561 USA.
RP Smith, LM (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Lab, Gulf Breeze, FL 32561 USA.
EM smith.lisam@epa.gov
FU US Environmental Protection Agency
FX The information in this document has been funded wholly (or in part) by
the US Environmental Protection Agency. It has been subjected to review
by the National Health and Environmental Effects Research Laboratory and
approved for publication. Approval does not signify that the contents
reflect the views of the Agency, nor does mention of trade names or
commercial products constitute endorsement or recommendation for use.
This is contribution number 1320 from the Gulf Ecology Division.
NR 35
TC 1
Z9 1
U1 1
U2 6
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6369
J9 ENVIRON MONIT ASSESS
JI Environ. Monit. Assess.
PD DEC
PY 2010
VL 171
IS 1-4
BP 611
EP 620
DI 10.1007/s10661-009-1303-0
PG 10
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 672NQ
UT WOS:000283592800047
PM 20082136
ER
PT J
AU Allen, HJ
Impellitteri, CA
Macke, DA
Heckman, JL
Poynton, HC
Lazorchak, JM
Govindaswamy, S
Roose, DL
Nadagouda, MN
AF Allen, H. Joel
Impellitteri, Christopher A.
Macke, Dana A.
Heckman, J. Lee
Poynton, Helen C.
Lazorchak, James M.
Govindaswamy, Shekar
Roose, Deborah L.
Nadagouda, Mallikarjuna N.
TI EFFECTS FROM FILTRATION, CAPPING AGENTS, AND PRESENCE/ABSENCE OF FOOD ON
THE TOXICITY OF SILVER NANOPARTICLES TO DAPHNIA MAGNA
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Silver; Nanoparticles; Daphnia magna; Aquatic toxicity
ID WALLED CARBON NANOTUBES; ZNO WATER SUSPENSIONS; ONCORHYNCHUS-MYKISS;
RAINBOW-TROUT; TIO2; SIO2; C-60
AB Relatively little is known about the behavior and toxicity of nanoparticles in the environment Objectives of work presented here include establishing the toxicity of a variety of silver nanoparticles (AgNPs) to Daphnia magna neonates assessing the applicability of a commonly used bioassay for testing AgNPs and determining the advantages and disadvantages of multiple characterization techniques for AgNPs in simple aquatic systems Daphnia magna were exposed to a silver nitrate solution and AgNPs suspensions including commercially available AgNPs (uncoated and coated) and laboratory synthesized AgNPs (coated with coffee or citrate) The nanoparticle suspensions were analyzed for silver concentration (microwave acid digestions) size (dynamic light scattering and electron microscopy) shape (electron microscopy) surface charge (zeta potentiometer) and chemical speciation (X ray absorption spectro scopy X ray diffraction) Toxicities of filtered (100 nm) versus unfiltered suspensions were compared Additionally effects from addition of food were examined Stock suspensions were prepared by adding AgNPs to moderately hard reconstituted water which were then diluted and used straight or after filtration with 100 nm filters All nanoparticle exposure suspensions at every time interval were digested via microwave digester and analyzed by inductively coupled argon plasma optical emission spectroscopy or graphite furnace atomic absorption spectroscopy Dose response curves were generated and median lethal concentration (LC50) values calculated The LC50 values for the unfiltered particles were (in mu g/L) 11 +/- 0 1 AgNO(3) 1 0 +/- 0 1 coffee coated 1 1 +/- 0 2 citrate coated 16 7 +/- 1 2 4 Sigma Aldrich Ag nanoparticles (SA) uncoated 31 5 8 1 SA coated LC50 values for the filtered particles were (in g/L) 0 7 +/- 0 1 AgNO(3) 1 4 +/- 0 1 SA uncoated 4 4 +/- 1 4 SA coated The LC50 resulting from the addition of food was 176 4 +/- 25 5 SA coated Recommendations presented in this study include AgNP handling methods effects from sample preparation and advantages/disadvantages of different nanoparticle characterization techniques Environ Toxicol Chem 2010 29 2742-2750 (C) 2010 SETAC
C1 [Allen, H. Joel; Impellitteri, Christopher A.; Macke, Dana A.; Poynton, Helen C.; Lazorchak, James M.; Roose, Deborah L.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
[Govindaswamy, Shekar] US EPA, Lakeshore Engn Serv, Test & Evaluat Facil, Cincinnati, OH 45268 USA.
[Nadagouda, Mallikarjuna N.] Pegasus Tech Serv, Cincinnati, OH USA.
RP Impellitteri, CA (reprint author), US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
OI Lazorchak, James/0000-0002-7354-7571
NR 37
TC 63
Z9 64
U1 3
U2 88
PU SETAC PRESS
PI PENSACOLA
PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA
SN 0730-7268
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD DEC
PY 2010
VL 29
IS 12
BP 2742
EP 2750
DI 10.1002/etc.329
PG 9
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 686FW
UT WOS:000284683200014
PM 20890913
ER
PT J
AU Stanley, JK
Kennedy, AJ
Farrar, JD
Mount, DR
Steevens, JA
AF Stanley, Jacob K.
Kennedy, Alan J.
Farrar, J. Daniel
Mount, David R.
Steevens, Jeffery A.
TI EVALUATION OF REDUCED SEDIMENT VOLUME PROCEDURES FOR ACUTE TOXICITY
TESTS USING THE ESTUARINE AMPHIPOD LEPTOCHEIRUS PLUMULOSUS
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Leptochetrus plumulosus; Sediment volume; Lead; Polycyclic aromatic
hydrocarbon; Test method
ID MODEL
AB The volume of sediment required to perform a sediment toxicity bioassay is a major driver of the overall cost associated with that bioassay Sediment volume affects bioassay cost because of sediment collection transportation storage and disposal costs as well as labor costs associated with organism recovery at the conclusion of the exposure The objective of the current study was to evaluate reduced sediment volume versions of the standard U S Environmental Protection Agency (U S EPA) 10 d acute Leptocheirus plumulosus method that uses a beaker size of 1 000 ml and 20 organisms The test design used evaluated the effects of beaker size (250 and 100 ml) and associated sediment volume (75 and 30ml respectively) as well as organism loading density (10 and 20 organisms) on test endpoint responsiveness relative to the standard 10 d test method These comparisons were completed with three different types of contaminated sediments a field collected polycyclic aromatic hydrocarbon (PAH) contaminated sediment a lead spiked control sediment and a control sediment spiked with mineral oil Assessment criteria included test endpoint sensitivity endpoint consistency statistical power water quality and logistical assessments Results indicate that the current U S EPA method is preferable to the reduced sediment volume methods we assessed but that a 250 ml beaker/10 organism experimental design is of comparable utility and may be advantareous when reduced sediment volumes are desirable because of high contaminant (spiking studies) or sediment disposal costs In addition the results of the current study provide toxicity reference values for PAHs lead and an oil surrogate for petroleum hydrocarbons Environ Toxicol Chem 2010 29 2769-2776 (C) 2010 SETAC
C1 [Stanley, Jacob K.; Kennedy, Alan J.; Farrar, J. Daniel; Steevens, Jeffery A.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
[Mount, David R.] US EPA, Off Res & Dev, Environm Effects Res Lab, Duluth, MN 55804 USA.
RP Stanley, JK (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
FU U S Army Corps of Engineers Dredging Operations Environmental Research
(DOER)
FX The views expressed are those of the authors and do not necessarily
reflect the policy positions of the U S EPA Mention of trade names or
commercial products does not constitute endorsement or recommendation
for use Permission has been granted by the Chief of Engineers to publish
this material Funding for this work came from the U S Army Corps of
Engineers Dredging Operations Environmental Research (DOER) program
(Todd S Bridges Program Manager) The authors thank Jamma Williams
Jennifer Goss and Jerre Sims of the US Army Engineer Research and
Development Center s Environmental Laboratory and J Russell Hockett and
Correne T Jenson of the U S EPA s Office of Research and Development for
technical support
NR 17
TC 4
Z9 4
U1 0
U2 6
PU SETAC PRESS
PI PENSACOLA
PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA
SN 0730-7268
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD DEC
PY 2010
VL 29
IS 12
BP 2769
EP 2776
DI 10.1002/etc.333
PG 8
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 686FW
UT WOS:000284683200017
PM 20890914
ER
PT J
AU Paul, KB
Hedge, JM
DeVito, MJ
Crofton, KM
AF Paul, Katie B.
Hedge, Joan M.
DeVito, Michael J.
Crofton, Kevin M.
TI DEVELOPMENTAL TRICLOSAN EXPOSURE DECREASES MATERNAL AND NEONATAL
THYROXINE IN RATS
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Endocrine disruptors; Developmental toxicity; Mammals; Triclosan
ID PERSONAL CARE PRODUCTS; THYROID-HORMONE DISRUPTION; IN-VIVO EXPOSURE;
WASTE-WATER; SHORT-TERM; EARLY-PREGNANCY; POLYCHLORINATED-BIPHENYLS;
NONSTEROIDAL ESTROGEN; DIPHENYL ETHERS; BRAIN
AB Disruption of maternal thyroid hormones during fetal developmental may result in irreversible neurological consequences in offspring The present study tested the hypothesis that perinatal triclosan exposure of dams decreases thyroxine in dams and offspring prior to weaning Pregnant Long Evans rats received triclosan by oral gavage (0-300 mg/kg/d) in corn oil from gestational day (GD)6 through postnatal day (PND)21 Serum was obtained from pups on PND4 14 and 21 and from dams on PND22 Serum thyroxine (T4) was reduced 31% in dams on PND22 In pups a unique pattern of hypothyroxinemia was observed serum T4 decreased 27% in PND4 pups with no significant reduction observed on PND14 or PND21 Comparable reductions of approximately 30% in serum T4 at 300 mg/kg/d for dams and PND4 neonates and a lack of effect at PND14 and PND21 suggest that toxicokinetic or toxicodynamic factors may have contributed to a reduced exposure or a reduced toxicological response during the lactation period Environ Toxicol Chem 2010 29 2840-2844 (C) 2010 SETAC
C1 [Paul, Katie B.; Crofton, Kevin M.] Univ N Carolina, Chapel Hill, NC 27515 USA.
[Hedge, Joan M.; Crofton, Kevin M.] US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[DeVito, Michael J.] Natl Inst Environm Hlth Sci, Natl Toxicol Program, Res Triangle Pk, NC USA.
RP Crofton, KM (reprint author), Univ N Carolina, Chapel Hill, NC 27515 USA.
RI Crofton, Kevin/J-4798-2015
OI Crofton, Kevin/0000-0003-1749-9971
FU PhRMA Foundation; EPA/UNC [CR833237]; National Institute of
Environmental Health Science [T32 ES07126]
FX This manuscript has been reviewed by the National Health and
Environmental Effects Research Laboratory U S Environmental Protection
Agency and approved for publication Mention of trade names or commercial
products does not constitute endorsement or recommendation for use The
authors thank David Ross and Kateland Grant for assistance during animal
sacrifice Ram Ramabhadran Sid Hunter William Mundy Tammy Stoker Doug
Wolf and Leah Zorrilla are gratefully acknowledged for comments on an
earlier version of this manuscript Triclosan was a generous gift from
James Plautz and Lisa Navarro of Ciba Specialty Chemicals Raw data files
can be obtained by contacting the corresponding author K B Paul was
funded by a PhRMA Foundation Predoctoral Pharmacology/Toxicology
Fellowship the EPA/UNC Toxicology Research Program Training Agreement
(CR833237) and the National Institute of Environmental Health Science
Training Grant (T32 ES07126) during this work
NR 43
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U2 20
PU SETAC PRESS
PI PENSACOLA
PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA
SN 0730-7268
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD DEC
PY 2010
VL 29
IS 12
BP 2840
EP 2844
DI 10.1002/etc.339
PG 5
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 686FW
UT WOS:000284683200026
PM 20954233
ER
PT J
AU Werner, I
Deanovic, LA
Miller, J
Denton, DL
Crane, D
Mekebri, A
Moore, MT
Wrysinski, J
AF Werner, Inge
Deanovic, Linda A.
Miller, Jeff
Denton, Debra L.
Crane, David
Mekebri, Abdou
Moore, Matthew T.
Wrysinski, Jeanette
TI USE OF VEGETATED AGRICULTURAL DRAINAGE DITCHES TO DECREASE TOXICITY OF
IRRIGATION RUNOFF FROM TOMATO AND ALFALFA FIELDS IN CALIFORNIA, USA
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Permethrin; Chlorpyrifos; Agricultural runoff; Hyalella azteca;
Ceriodaphnia dubia
ID MINNOW PIMEPHALES-PROMELAS; HYALELLA-AZTECA; PYRETHROID PESTICIDES;
CHIRONOMUS-TENTANS; WATER; CHLORPYRIFOS; CONTAMINATION; ESFENVALERATE;
TEMPERATURE; MITIGATION
AB The current study investigated the potential of vegetated drainage ditches for mitigating the impact of agricultural irrigation runoff on downstream aquatic ecosystems Water column toxicity to larval fathead minnow (Pimephales promelas) and the amphipod Hyalella azteca was measured for 12h or less at the ditch inflow and outflow using custom built in situ exposure systems In addition water and sediment samples were subject to standard toxicity tests with Ceriodaphnia dubia and H azteca respectively No acute toxicity to larval fathead minnow was observed however runoff was highly toxic to invertebrates Passage through a 389 to 402 m section of vegetated ditch had a mitigating effect and reduced toxicity to some degree However runoff from an alfalfa field treated with chlorpyrifos remained highly toxic to both invertebrate species and runoff from a tomato field treated with permethrin remained highly toxic to H azteca after passage through the ditch Predicted toxic units calculated from insecticide concentrations in runoff and 96 h median lethal concentration (LC50) values generally agreed with C dubia toxicity measured in the laboratory but significantly underestimated in situ toxicity to H azteca Sediments collected near the ditch outflow were toxic to H azteca Results from the current study demonstrate that experimental vegetated ditches were unable to eliminate the risk of irrigation runoff to aquatic ecosystems In addition protective measures based on chemical concentrations or laboratory toxicity tests with C dubia do not ensure adequate protection of aquatic ecosystems from pyrethroid associated toxicity Environ Toxicol Chem 2010 29 2859-2868 (C) 2010 SETAC
C1 [Werner, Inge; Deanovic, Linda A.] Univ Calif Davis, Aquat Toxicol Lab, Sch Vet Med, Davis, CA 95616 USA.
[Miller, Jeff] AQUA Sci, Davis, CA USA.
[Denton, Debra L.] US EPA, Sacramento, CA 95814 USA.
[Crane, David; Mekebri, Abdou] Water Pollut Control Lab, Dept Fish & Game, Rancho Cordova, CA USA.
[Moore, Matthew T.] ARS, USDA, Natl Sedimentat Lab, Oxford, MS USA.
[Wrysinski, Jeanette] Yolo Cty Resource Conservat Distnct, Woodland, CA USA.
RP Werner, I (reprint author), Univ Calif Davis, Aquat Toxicol Lab, Sch Vet Med, Davis, CA 95616 USA.
FU California State Water Resources Control Board (SWRCB) [04 070 555 0]
FX The authors would like to thank the staff of the UC Davis Aquatic
Toxicology Laboratory in particular Charissa Reece Mane Stillway and Dan
Markiewicz for their hard work on this project Additional enthusiastic
supporters such as Richard Connon and Tony Ha were invaluable during the
long field days and nights We thank Michelle Hladik U S Geological
Society (Sacramento CA USA) for providing analytical support for the
pesticide adsorption study Funding for this project has been provided by
the California State Water Resources Control Board (SWRCB grant 04 070
555 0 to Yolo County Resource Conservation District) Contents of this
document do not necessarily reflect the views and policies of the SWRCB
NR 40
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U2 18
PU SETAC PRESS
PI PENSACOLA
PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA
SN 0730-7268
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD DEC
PY 2010
VL 29
IS 12
BP 2859
EP 2868
DI 10.1002/etc.356
PG 10
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 686FW
UT WOS:000284683200029
PM 20836062
ER
PT J
AU Sriram, K
Lin, GX
Jefferson, AM
Roberts, JR
Wirth, O
Hayashi, Y
Krajnak, KM
Soukup, JM
Ghio, AJ
Reynolds, SH
Castranova, V
Munson, AE
Antonini, JM
AF Sriram, Krishnan
Lin, Gary X.
Jefferson, Amy M.
Roberts, Jenny R.
Wirth, Oliver
Hayashi, Yusuke
Krajnak, Kristine M.
Soukup, Joleen M.
Ghio, Andrew J.
Reynolds, Steven H.
Castranova, Vincent
Munson, Albert E.
Antonini, James M.
TI Mitochondrial dysfunction and loss of Parkinson's disease-linked
proteins contribute to neurotoxicity of manganese-containing welding
fumes
SO FASEB JOURNAL
LA English
DT Article
DE brain; DJ-1; neurodegeneration; Park genes; proteasome;
ubiquitin-proteasome pathway
ID EARLY-ONSET PARKINSONISM; OXIDATIVE STRESS; CELL-DEATH;
NEURODEGENERATIVE DISEASES; PERMEABILITY TRANSITION; JUVENILE
PARKINSONISM; NEUROLOGICAL DISEASE; CEREBROSPINAL-FLUID; S18Y
POLYMORPHISM; ALPHA-SYNUCLEIN
AB Welding generates complex metal aerosols, inhalation of which is linked to adverse health effects among welders. An important health concern of welding fume (WF) exposure is neurological dysfunction akin to Parkinson's disease (PD), thought to be mediated by manganese (Mn) in the fumes. Also, there is a proposition that welding might accelerate the onset of PD. Our recent findings link the presence of Mn in the WF with dopaminergic neurotoxicity seen in rats exposed to manual metal arc-hard surfacing (MMA-HS) or gas metal arc-mild steel (GMA-MS) fumes. To elucidate the molecular mechanisms further, we investigated the association of PD-linked (Park) genes and mitochondrial function in causing dopaminergic abnormality. Repeated instillations of the two fumes at doses that mimic similar to 1 to 5 yr of worker exposure resulted in selective brain accumulation of Mn. This accumulation caused impairment of mitochondrial function and loss of tyrosine hydroxylase (TH) protein, indicative of dopaminergic injury. A fascinating finding was the altered expression of Parkin (Park2), Uchl1 (Park5), and Dj1 (Park7) proteins in dopaminergic brain areas. A similar regimen of manganese chloride (MnCl(2)) also caused extensive loss of striatal TH, mitochondrial electron transport components, and Park proteins. As mutations in PARK genes have been linked to early-onset PD in humans, and because welding is implicated as a risk factor for parkinsonism, PARK genes might play a critical role in WF-mediated dopaminergic dysfunction. Whether these molecular alterations culminate in neurobehavioral and neuropathological deficits reminiscent of PD remains to be ascertained.-Sriram, K., Lin, G. X., Jefferson, A. M., Roberts, J. R., Wirth, O., Hayashi, Y., Krajnak, K. M., Soukup, J. M., Ghio, A. J., Reynolds, S. H., Castranova, V., Munson, A. E., Antonini, J. M. Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumes. FASEB J. 24, 4989-5002 (2010). www.fasebj.org
C1 [Sriram, Krishnan] NIOSH, Toxicol & Mol Biol Branch, CDC, Hlth Effects Lab, Morgantown, WV 26505 USA.
[Soukup, Joleen M.; Ghio, Andrew J.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC USA.
RP Sriram, K (reprint author), NIOSH, Toxicol & Mol Biol Branch, CDC, Hlth Effects Lab, Mailstop L-3014,1095 Willowdale Rd, Morgantown, WV 26505 USA.
EM kos4@cdc.gov
NR 96
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U2 9
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD DEC
PY 2010
VL 24
IS 12
BP 4989
EP 5002
DI 10.1096/fj.10-163964
PG 14
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 688BO
UT WOS:000284824400037
PM 20798247
ER
PT J
AU Hamilton, AT
Barbour, MT
Bierwagen, BG
AF Hamilton, Anna T.
Barbour, Michael T.
Bierwagen, Britta G.
TI Implications of global change for the maintenance of water quality and
ecological integrity in the context of current water laws and
environmental policies
SO HYDROBIOLOGIA
LA English
DT Article
DE Global change; Climate change; Water law; Environmental policy;
Bioassessment
ID STREAM MACROINVERTEBRATE COMMUNITIES; MULTIPLE SOURCE ASSESSMENT;
LIFE-HISTORY STRATEGIES; RECENT CLIMATE-CHANGE; BIOLOGICAL TRAITS;
SPECIES RICHNESS; LAND-USE; ECOSYSTEM HEALTH; CATCHMENTS INCA; AQUATIC
INSECTS
AB There is both a fundamental and applied need to define expectations of changes in aquatic ecosystems due to global changes. It is clear that programs using biological indicators and reference-based comparisons as the foundation for assessments are likely to make increasingly erroneous decisions if the impacts of global change are ignored. Global changes influence all aspects of water resource management decisions based on comparisons to reference conditions with impacts making it increasingly problematic to find an "undisturbed" water body to define acceptable conditions of ecological integrity. Using a more objective scale for characterizing reference conditions that is anchored in expectations for what would be attainable under undisturbed conditions, such as the Biological Condition Gradient (BCG) is one approach that maintains consistent definitions for ecosystem conditions. In addition, protection of reference stations and of unique or undisturbed aquatic resources is imperative, though the scope of protection options is limited. Projections indicate that encroaching land use will affect 36-48% of current reference surface waters by the year 2100. The interpretation of biological indicators is also at risk from global changes. Distinguishing taxonomic attributes based on temperature or hydrologic preferences can be used to enhance the ability to make inferences about global change effects compared to other stressors. Difficulties arise in categorizing unique indicators of global changes, because of similarities in some of the temperature and hydrologic effects resulting from climate change, land use changes, and water removal. In the quest for biological indicators that might be uniquely sensitive to one global stressor as an aid in recognizing probable causes of ecosystem damage, the potential similarities in indicator responses among global and landscape-scale changes needs to be recognized as a limiting factor. Many aspects of global changes are not tractable at the local to regional scales at which water quality regulations are typically managed. Our ability to implement water policies through bioassessment will require a shift in the scale of assessment, planning, and adaptations in order to fulfill our ultimate regulatory goals of preserving good water quality and ecological integrity. Providing clear expectations of effects due to global change for key species and communities in freshwater ecosystems will help water quality programs achieve their goals under changing environmental conditions.
C1 [Hamilton, Anna T.; Barbour, Michael T.] Tetra Tech Inc, Ctr Ecol Sci, Santa Fe, NM USA.
[Bierwagen, Britta G.] US EPA, Global Change Res Program, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
RP Hamilton, AT (reprint author), Tetra Tech Inc, Ctr Ecol Sci, Santa Fe, NM USA.
EM Anna.Hamilton@tetratech.com; Michael.Barbour@tetratech.com;
Bierwagen.Britta@epa.gov
RI Bierwagen, Britta/G-5943-2010
FU National Center for Environmental Assessment in the U.S. Environmental
Protection Agency's Office of Research and Development [GS-10F-0268K, DO
1107]
FX The authors would like to thank L. Yuan, R. Novak, K. Metchis, and
several anonymous reviewers for their comments, which greatly improved
this article. The authors would also like to thank R. Cantilli of the
U.S. EPA for supporting some of our initial thinking on climate change
implications to water policy. The Global Change Research Program in the
National Center for Environmental Assessment in the U.S. Environmental
Protection Agency's Office of Research and Development provided
financial support for the analyses contributing to this article through
contract # GS-10F-0268K, DO 1107 to Tetra Tech, Inc. The views expressed
in this article are those of the authors and they do not necessarily
reflect the views or policies of the U.S. Environmental Protection
Agency.
NR 83
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U1 1
U2 37
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0018-8158
J9 HYDROBIOLOGIA
JI Hydrobiologia
PD DEC
PY 2010
VL 657
IS 1
BP 263
EP 278
DI 10.1007/s10750-010-0316-6
PG 16
WC Marine & Freshwater Biology
SC Marine & Freshwater Biology
GA 656IP
UT WOS:000282323300018
ER
PT J
AU Solomon, PA
AF Solomon, Paul A.
TI Special Issue of Inhalation Toxicology for Air Pollution and Health:
Bridging the Gap from Sources-to-Health Outcomes
SO INHALATION TOXICOLOGY
LA English
DT Editorial Material
C1 US EPA, Off Res & Dev, Las Vegas, NV 89119 USA.
RP Solomon, PA (reprint author), US EPA, Off Res & Dev, 944 E Harmon Ave, Las Vegas, NV 89119 USA.
EM solomon.paul@epa.gov
NR 11
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Z9 4
U1 0
U2 0
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0895-8378
J9 INHAL TOXICOL
JI Inhal. Toxicol.
PD DEC
PY 2010
VL 22
SU 2
BP 1
EP 5
DI 10.3109/08958378.2010.539633
PG 5
WC Toxicology
SC Toxicology
GA 693AP
UT WOS:000285197300001
PM 21142795
ER
PT J
AU Johns, DO
Svendsgaard, D
Linn, WS
AF Johns, Douglas O.
Svendsgaard, David
Linn, William S.
TI Analysis of the concentration-respiratory response among asthmatics
following controlled short-term exposures to sulfur dioxide
SO INHALATION TOXICOLOGY
LA English
DT Article
DE Sulfur dioxide; controlled human exposures; National Ambient Air Quality
Standards; concentration-response; bronchoconstriction; asthma
ID INDUCED BRONCHOCONSTRICTION; DOSE-RESPONSE; SYMPTOM PERCEPTION;
EXERCISE; RESPONSIVENESS; ADOLESCENTS; VOLUNTEERS
AB Some of the most compelling evidence of sulfur dioxide (SO2)-induced respiratory morbidity is derived from a large body of studies involving controlled short-term exposures among groups of asthmatic volunteers. These studies were extensively cited in the recently completed review of the primary National Ambient Air Quality Standards for SO2. Although it is clear from these investigations that exposure to SO2 may result in a significant increase in bronchoconstriction, there is uncertainty regarding the range of concentrations over which this respiratory response occurs. The objective of this study was to better characterize the concentration-response relationship between SO2 and measures of bronchoconstriction using individual subject lung function response data. In reviewing studies of asthmatics exposed to SO2 during 5- to 10-min periods of elevated ventilation, we observed clear and consistent evidence of an increase in the bronchoconstrictive response to SO2 with increasing exposure concentrations between 0.2 and 1.0 ppm. In a subsequent analysis of individual subject data, it was found that those asthmatics experiencing SO2-induced respiratory effects at relatively high exposure concentrations are also more likely than nonresponders to experience similar effects after exposure to lower SO2 concentrations (<= 0.4 ppm). Although the clinical significance of these effects is unsettled, the findings provide additional support to epidemiologic evidence of an association between ambient SO2 concentration and various measures of respiratory morbidity in the general population.
C1 [Johns, Douglas O.; Svendsgaard, David] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA.
[Linn, William S.] Los Amigos Res & Educ Inst, Downey, CA USA.
[Linn, William S.] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA.
RP Johns, DO (reprint author), US EPA, Off Res & Dev, Natl Ctr Environm Assessment, 109 TW Alexander Dr,Mail Code B243-01, Res Triangle Pk, NC 27711 USA.
EM johns.doug@epa.gov
FU National Institute of Environmental Health Sciences [5P30ES007048];
Children's Environmental Health Center [s 5P01ES009581, R826708-01,
RD831861-01]; National Institute of Environmental Health Sciences and
the Environmental Protection Agency; American Petroleum Institute
FX The views expressed in this article are those of the authors and do not
necessarily reflect the views or policies of the U.S. Environmental
Protection Agency. During the writing of this article, W.S. Linn
received support from Southern California Environmental Health Sciences
Center (grant # 5P30ES007048) funded by the National Institute of
Environmental Health Sciences, from the Children's Environmental Health
Center (grant #s 5P01ES009581, R826708-01 and RD831861-01) funded by the
National Institute of Environmental Health Sciences and the
Environmental Protection Agency, and from the American Petroleum
Institute.
NR 30
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U1 0
U2 5
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0895-8378
J9 INHAL TOXICOL
JI Inhal. Toxicol.
PD DEC
PY 2010
VL 22
IS 14
BP 1184
EP 1193
DI 10.3109/08958378.2010.535220
PG 10
WC Toxicology
SC Toxicology
GA 688XH
UT WOS:000284889300006
PM 21126154
ER
PT J
AU Travers, D
AF Travers, David
TI Water Security e-Tools. Greater Preparedness and Resiliency From Your
Desktop
SO JOURNAL AMERICAN WATER WORKS ASSOCIATION
LA English
DT Editorial Material
C1 [Travers, David] US EPA, Off Ground Water & Drinking Water, Water Secur Div, Washington, DC USA.
RP Travers, D (reprint author), US EPA, Off Ground Water & Drinking Water, Water Secur Div, Washington, DC USA.
NR 0
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U1 0
U2 4
PU AMER WATER WORKS ASSOC
PI DENVER
PA 6666 W QUINCY AVE, DENVER, CO 80235 USA
SN 0003-150X
J9 J AM WATER WORKS ASS
JI J. Am. Water Work Assoc.
PD DEC
PY 2010
VL 102
IS 12
BP 24
EP 26
PG 3
WC Engineering, Civil; Water Resources
SC Engineering; Water Resources
GA 703CX
UT WOS:000285952800010
ER
PT J
AU Yeatts, SD
Gennings, C
Wagner, ED
Simmons, JE
Plewa, MJ
AF Yeatts, Sharon D.
Gennings, Chris
Wagner, Elizabeth D.
Simmons, Jane Ellen
Plewa, Michael J.
TI Detecting Departure From Additivity Along a Fixed-Ratio Mixture Ray With
a Piecewise Model for Dose and Interaction Thresholds
SO JOURNAL OF AGRICULTURAL BIOLOGICAL AND ENVIRONMENTAL STATISTICS
LA English
DT Article
DE Dose threshold; Dose-dependent interaction; Synergy
ID DISINFECTION BY-PRODUCTS; MAMMALIAN-CELL CYTOTOXICITY; GENOTOXICITY;
TOXICOLOGY; EXPOSURE; IMPACT
AB For mixtures of many chemicals, a ray design based on a relevant, fixed mixing ratio is useful for detecting departure from additivity. Methods for detecting departure involve modeling the response as a function of total dose along the ray. For mixtures with many components, the interaction may be dose dependent. Therefore, we have developed the use of a three-segment model containing both a dose threshold and an interaction threshold. Prior to the dose threshold, the response is that of background; between the dose threshold and the interaction threshold, an additive relationship exists; the model allows for departure from additivity beyond the interaction threshold. With such a model, we can conduct a hypothesis test of additivity, as well as a test for a region of additivity. The methods are illustrated with cytotoxicity data that arise when Chinese hamster ovary cells are exposed to a mixture of nine haloacetic acids.
C1 [Yeatts, Sharon D.] Med Univ S Carolina, Dept Med, Charleston, SC 29425 USA.
[Gennings, Chris] Virginia Commonwealth Univ, Dept Biostat, Richmond, VA USA.
[Wagner, Elizabeth D.; Plewa, Michael J.] Univ Illinois, Dept Crop Sci, Urbana, IL 61801 USA.
[Simmons, Jane Ellen] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
RP Yeatts, SD (reprint author), Med Univ S Carolina, Dept Med, 135 Cannon St,Suite 303,MSC 835, Charleston, SC 29425 USA.
EM yeatts@musc.edu
FU National Institute of Environmental Health Sciences, National Institutes
of Health [T32 007334]; Center of Advanced Materials for the
Purification of Water with Systems, a National Science Foundation
Science and Technology Center [CTS 0120978]
FX The research presented in this article was supported in part by the
National Institute of Environmental Health Sciences, National Institutes
of Health grant T32 007334 (SY) and the Center of Advanced Materials for
the Purification of Water with Systems, a National Science Foundation
Science and Technology Center Award CTS 0120978 (MP). The authors thank
the associate editor and the two anonymous referees for their helpful
comments on the earlier version of this manuscript.
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U1 1
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1085-7117
J9 J AGR BIOL ENVIR ST
JI J. Agric. Biol. Environ. Stat.
PD DEC
PY 2010
VL 15
IS 4
BP 510
EP 522
DI 10.1007/s13253-010-0030-x
PG 13
WC Biology; Mathematical & Computational Biology; Statistics & Probability
SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational
Biology; Mathematics
GA 688MD
UT WOS:000284852500006
PM 21359103
ER
PT J
AU Testa, JW
Adams, GP
Bergfelt, DR
Johnson, DS
Ream, RR
Gelatt, TS
AF Testa, J. Ward
Adams, Gregg P.
Bergfelt, Don R.
Johnson, Devin S.
Ream, Rolf R.
Gelatt, Thomas S.
TI Replicating necropsy data without lethal collections: using
ultrasonography to understand the decline in northern fur seals
SO JOURNAL OF APPLIED ECOLOGY
LA English
DT Article
DE Alaska; Bering Sea; Callorhinus ursinus; embryonic diapause; fecundity;
Pribilof Islands; St. Paul Island
ID MOOSE ALCES-ALCES; CALLORHINUS-URSINUS; POPULATION-DYNAMICS; GREY SEALS;
HALICHOERUS-GRYPUS; LOXODONTA-AFRICANA; PUP PRODUCTION; BODY CONDITION;
PREGNANCY; ULTRASOUND
AB 1. Many valuable contributions to the biology and conservation of harvested or previously harvested species have come from examination of specimens obtained by lethal collections. The northern fur seal Callorhinus ursinus on the Pribilof Islands, Alaska, has a long history of exploitation, including a large (> 320 000) experimental harvest of females from 1955 to 1968 when the population was at a peak (similar to 2 million seals). The decline caused by this harvest was followed in 1977 by another major decline, apparently unrelated to harvest, that has recently accelerated.
2. To obtain current reproductive data that could be compared directly with historic estimates, we used imaging ultrasonography to estimate pregnancy rate in 171 adult fur seals captured on St. Paul Island, Alaska, in November, near the end of embryonic diapause. A modified logistic regression of pregnancy by date was used to estimate asymptotic pregnancy rate; a Bayesian hierarchical model based on date and size of embryonic vesicle was also used to account for pregnancies that were not detectable on the date of examination.
3. Pregnancy rate was high [0.85 (SE = 0.05), 0.88 (SE = 0.05) or 0.92 (SE = 0.04), depending on method] and there was little statistical support for the hypothesis that the current pregnancy rate is lower than the pre-decline rate (0.84, SE = 0.012) or contributing significantly to the present decline.
4. Synthesis and applications. Further study on intrauterine losses and pupping rates is necessary and ongoing, but reproductive ultrasonography provided an early comparative assessment important for the conservation management of this fur seal stock. It narrows the search for demographic and ecological causes of the population decline and allows research priorities to evolve in response to the likelihood of those causes. The field and analytic methods described have application to population assessments of other mammalian species, including those considered threatened or serving as ecosystem indicators.
C1 [Testa, J. Ward; Johnson, Devin S.; Ream, Rolf R.; Gelatt, Thomas S.] Alaska Fisheries Sci Ctr, Natl Marine Mammal Lab, Seattle, WA 98115 USA.
[Testa, J. Ward] Univ Alaska, Dept Biol Sci, Anchorage, AK 99508 USA.
[Adams, Gregg P.] Univ Saskatchewan, Western Coll Vet Med, Saskatoon, SK S7N 5B4, Canada.
[Bergfelt, Don R.] US EPA, Off Sci Coordinat & Policy, Washington, DC 20460 USA.
RP Testa, JW (reprint author), Alaska Fisheries Sci Ctr, Natl Marine Mammal Lab, 7600 Sand Point Way NE, Seattle, WA 98115 USA.
EM ward.testa@noaa.gov
FU National Marine Mammal Laboratory; Alaska Fisheries Science Center; U.S.
Environmental Protection Agency; Western College of Veterinary Medicine;
University of Saskatchewan
FX We wish to thank J. Baker, D. Deghetto, E. C. Goertz, C. Kuhn, E.
Kunisch, B. Page, P. Pomeroy, J. Sterling, J. Thomason and M. Williams
for their assistance in the field. Support was provided by the National
Marine Mammal Laboratory, Alaska Fisheries Science Center. Support for
DRB was provided by the U.S. Environmental Protection Agency. GPA was
supported by the Western College of Veterinary Medicine, University of
Saskatchewan. We thank J. Baker, LL. Boyd and P. P. Pomeroy and 4
anonymous reviewers for constructive comments on the manuscript. Fur
seal captures were conducted under Marine Mammal Protection Act Permit
No. 782-1708-00 issued to the National Marine Mammal Laboratory.
Reference to trade names does not imply endorsement by the National
Marine Fisheries Service, U.S. National Oceanic and Atmospheric
Administration.
NR 62
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U1 3
U2 10
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0021-8901
J9 J APPL ECOL
JI J. Appl. Ecol.
PD DEC
PY 2010
VL 47
IS 6
BP 1199
EP 1206
DI 10.1111/j.1365-2664.2010.01888.x
PG 8
WC Biodiversity Conservation; Ecology
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 677IQ
UT WOS:000283983200006
ER
PT J
AU Sushko, I
Novotarskyi, S
Korner, R
Pandey, AK
Cherkasov, A
Lo, JZ
Gramatica, P
Hansen, K
Schroeter, T
Muller, KR
Xi, LL
Liu, HX
Yao, XJ
Oberg, T
Hormozdiari, F
Dao, PH
Sahinalp, C
Todeschini, R
Polishchuk, P
Artemenko, A
Kuz'min, V
Martin, TM
Young, DM
Fourches, D
Muratov, E
Tropsha, A
Baskin, I
Horvath, D
Marcou, G
Muller, C
Varnek, A
Prokopenko, VV
Tetko, IV
AF Sushko, Iurii
Novotarskyi, Sergii
Koerner, Robert
Pandey, Anil Kumar
Cherkasov, Artem
Lo, Jiazhong
Gramatica, Paola
Hansen, Katja
Schroeter, Timon
Mueller, Klaus-Robert
Xi, Lili
Liu, Huanxiang
Yao, Xiaojun
Oberg, Tomas
Hormozdiari, Farhad
Dao, Phuong
Sahinalp, Cenk
Todeschini, Roberto
Polishchuk, Pavel
Artemenko, Anatoliy
Kuz'min, Victor
Martin, Todd M.
Young, Douglas M.
Fourches, Denis
Muratov, Eugene
Tropsha, Alexander
Baskin, Igor
Horvath, Dragos
Marcou, Gilles
Muller, Christophe
Varnek, Alexander
Prokopenko, Volodymyr V.
Tetko, Igor V.
TI Applicability Domains for Classification Problems: Benchmarking of
Distance to Models for Ames Mutagenicity Set
SO JOURNAL OF CHEMICAL INFORMATION AND MODELING
LA English
DT Article
ID ARTIFICIAL NEURAL NETWORKS; SUPPORT VECTOR MACHINES; PARTIAL
LEAST-SQUARES; E-STATE INDEXES; QUANTITATIVE STRUCTURE; UNCERTAINTY
ASSESSMENT; QSPR MODELS; QSAR MODELS; SELECTION; ACCURACY
AB The estimation of accuracy and applicability of QSAR and QSPR models for biological and physicochemical properties represents a critical problem. The developed parameter of "distance to model" (DM) is defined as a metric of similarity between the training and test set compounds that have been subjected to QSAR/QSPR modeling. In our previous work, we demonstrated the utility and optimal performance of DM metrics that have been based on the standard deviation within an ensemble of QSAR models. The current study applies such analysis to 30 QSAR models for the Ames mutagenicity data set that were previously reported within the 2009 QSAR challenge. We demonstrate that the DMs based on an ensemble (consensus) model provide systematically better performance than other DMs. The presented approach identifies 30-60% of compounds having an accuracy of prediction similar to the interlaboratory accuracy of the Ames test, which is estimated to be 90%. Thus, the in silico predictions can be used to halve the cost of experimental measurements by providing a similar prediction accuracy. The developed model has been made publicly available at http://ochem.eu/models/1.
C1 [Sushko, Iurii; Novotarskyi, Sergii; Koerner, Robert; Pandey, Anil Kumar; Tetko, Igor V.] German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Muenchen, Inst Bioinformat & Syst Biol, D-85764 Neuherberg, Germany.
[Cherkasov, Artem] Univ British Columbia, Vancouver Prostate Ctr, Vancouver, BC V6H 3Z6, Canada.
[Lo, Jiazhong; Gramatica, Paola] Univ Insubria, Dept Struct & Funct Biol, QSAR Res Unit Environm Chem & Ecotoxicol, I-21100 Varese, Italy.
[Hansen, Katja; Schroeter, Timon; Mueller, Klaus-Robert] Tech Univ Berlin, Machine Learning Dept, D-10587 Berlin, Germany.
[Schroeter, Timon] Bayer Schering Pharma AG, Nonclin Drug Safety, D-13353 Berlin, Germany.
[Xi, Lili; Yao, Xiaojun] Lanzhou Univ, Dept Chem, Lanzhou 730000, Peoples R China.
[Liu, Huanxiang] Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China.
[Oberg, Tomas] Linnaeis Univ, Sch Nat Sci, S-39182 Kalmar, Sweden.
[Hormozdiari, Farhad; Dao, Phuong; Sahinalp, Cenk] Simon Fraser Univ, Sch Comp Sci, Burnaby, BC V5A 1S6, Canada.
[Todeschini, Roberto] Univ Milano Bicocca, Dept Environm Sci, Milano Chemometr & QSAR Res Grp, I-20126 Milan, Italy.
[Polishchuk, Pavel; Artemenko, Anatoliy; Kuz'min, Victor; Muratov, Eugene] Natl Acad Sci Ukraine, AV Bogatsky Physicochem Inst, UA-65080 Odessa, Ukraine.
[Martin, Todd M.; Young, Douglas M.] US EPA, Clean Processes Branch, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
[Fourches, Denis; Muratov, Eugene; Tropsha, Alexander] Univ N Carolina, Lab Mol Modeling, Eshelman Sch Pharm, Chapel Hill, NC 27599 USA.
[Baskin, Igor] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119991, Russia.
[Horvath, Dragos; Marcou, Gilles; Muller, Christophe; Varnek, Alexander] Univ Strasbourg, CNRS, UMR 7177, Lab Infochim, F-67000 Strasbourg, France.
[Prokopenko, Volodymyr V.] Ukrainian Acad Sci, Inst Bioorgan & Petrochem, UA-02660 Kiev, Ukraine.
RP Tetko, IV (reprint author), German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Muenchen, Inst Bioinformat & Syst Biol, Ingolstaedter Landstr I, D-85764 Neuherberg, Germany.
EM itetko@vcclab.org
RI Oberg, Tomas/H-4543-2011; Cherkasov, Artem/A-2134-2012; Baskin,
Igor/I-2490-2012; Muller, Klaus/C-3196-2013; Todeschini,
Roberto/B-5868-2014; Muratov, Eugene/C-4454-2014; Tropsha,
Alexander/G-6245-2014; Tetko, Igor/B-1540-2010; MARCOU,
Gilles/F-8592-2015; Varnek, Alexandre/E-7076-2017
OI Oberg, Tomas/0000-0001-9382-9296; Gramatica, Paola/0000-0002-6364-6138;
Baskin, Igor/0000-0003-0874-1148; Todeschini,
Roberto/0000-0002-6454-4192; Muratov, Eugene/0000-0003-4616-7036; Tetko,
Igor/0000-0002-6855-0012; MARCOU, Gilles/0000-0003-1676-6708; Varnek,
Alexandre/0000-0003-1886-925X
FU GO-Bio BMBF [0313883]; FP7 project [CADASTER 212668]; Germany Ukraine
collaboration project UKR [08/006]; NIH [R01GM66940, R21GM076059]
FX This study was partially supported with GO-Bio BMBF grant 0313883, FP7
project CADASTER 212668, and Germany Ukraine collaboration project UKR
08/006, and by the NIH grants R01GM66940 and R21GM076059. We would like
to thank all participants of the Ames challenge, who contributed to the
development of models used in this study as well as the reviewers for
their constructive remarks.
NR 60
TC 87
Z9 87
U1 0
U2 32
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1549-9596
J9 J CHEM INF MODEL
JI J. Chem Inf. Model.
PD DEC
PY 2010
VL 50
IS 12
BP 2094
EP 2111
DI 10.1021/ci100253r
PG 18
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Computer Science,
Information Systems; Computer Science, Interdisciplinary Applications
SC Pharmacology & Pharmacy; Chemistry; Computer Science
GA 697ZL
UT WOS:000285559900004
PM 21033656
ER
PT J
AU Lu, HF
Bai, Y
Ren, H
Campbell, DE
AF Lu, Hongfang
Bai, Yu
Ren, Hai
Campbell, Daniel E.
TI Integrated emergy, energy and economic evaluation of rice and vegetable
production systems in alluvial paddy fields: Implications for
agricultural policy in China
SO JOURNAL OF ENVIRONMENTAL MANAGEMENT
LA English
DT Article
DE Rice production; Vegetable production; Ecological-economic efficiency;
Sustainability; Emergy analysis
ID POULTRY PRODUCTION; SUSTAINABILITY; FARMS; MANAGEMENT; BRAZIL; FISH
AB China is the largest rice producing and consuming country in the world, but rice production has given way to the production of vegetables during the past twenty years. The government has been trying to stop this land-use conversion and increase the area in rice-vegetable rotation. Important questions that must be answered to determine what strategy is best for society are, "What is the reason behind this conversion?"; "Which system is more productive and which is more sustainable?"; and "How can economic policy be used to adjust the pattern of farmland use to attain sustainable development?" To answer these questions, a combined evaluation of these agricultural production systems was done using emergy, energy and economic methods. An economic analysis clearly showed that the reason for this conversion was simply that the economic output/input ratio and the benefit density of the vegetable production system were greater than that of rice. However, both energy and emergy evaluations showed that long-term rice was the best choice for sustainable development, followed by rotation systems. The current price of rice is lower than the em-value of rice produced from the long-term rice system, but higher than that of rice produced from the rotation system. Scenario analysis showed that if the government increases the price of rice to the em-value of rice produced from the long-term rice system, US$0.4/kg, and takes the value of soil organic matter into account, the economic output/input ratios of both the rice and rotation systems will be higher than that of the vegetable system. The three methods, energy, emergy and economics, are different but complementary, each revealing a different aspect of the same system. Their combined use shows not only the reasons behind a system's current state or condition, but also the way to adjust these systems to move toward more sustainable states. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Lu, Hongfang; Ren, Hai] Chinese Acad Sci, S China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China.
[Bai, Yu] Haitong Secur Corp Ltd, Shanghai 200001, Peoples R China.
[Campbell, Daniel E.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI USA.
RP Ren, H (reprint author), Chinese Acad Sci, S China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China.
EM renhai@scbg.ac.cn
FU Major State Basic Research Development Program of China (973 Program)
[2009CB421101]; National Science Foundation of China [30600072]; Chinese
Academy of Sciences
FX We thank Mr. Xingfu Gu, Yuping Ye, and Huanbing Deng of the Agricultural
Bureau of Huiyang, and Mr. Qixin Zeng and Siwei Zhang at of the
Agriculture Office of Liangjing county in Huiyang, and the famers of the
24 study sites for help in site selection, sampling and investigation.
We also thank Mrs. Elisabeth C. Odum for help in improving the English
in this manuscript, and five anonymous reviewers for very helpful
comments and suggestions of the manuscript. This study was supported by
Projects of the Major State Basic Research Development Program of China
(973 Program, 2009CB421101), the National Science Foundation of China
(30600072), and the Director's Award of the Chinese Academy of Sciences.
This work is a contribution of the Key laboratory of vegetation
restoration and management of degraded ecosystems, South China Botanical
garden, Chinese Academy of Sciences.
NR 52
TC 36
Z9 40
U1 4
U2 46
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0301-4797
EI 1095-8630
J9 J ENVIRON MANAGE
JI J. Environ. Manage.
PD DEC
PY 2010
VL 91
IS 12
BP 2727
EP 2735
DI 10.1016/j.jenvman.2010.07.025
PG 9
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 663YN
UT WOS:000282926200039
PM 20702024
ER
PT J
AU Trebitz, AS
West, CW
Hoffman, JC
Kelly, JR
Peterson, GS
Grigorovich, IA
AF Trebitz, Anett S.
West, Corlis W.
Hoffman, Joel C.
Kelly, John R.
Peterson, Gregory S.
Grigorovich, Igor A.
TI Status of non-indigenous benthic invertebrates in the Duluth-Superior
Harbor and the role of sampling methods in their detection
SO JOURNAL OF GREAT LAKES RESEARCH
LA English
DT Article
DE Benthos; Non-native species; First detection; Gear effects; Taxonomy
ID LAURENTIAN GREAT-LAKES; AMPHIPOD GAMMARUS-TIGRINUS; COMMUNITY STRUCTURE;
ECHINOGAMMARUS-ISCHNUS; INVASION; HURON; INTRODUCTIONS; POPULATIONS;
FASCIATUS; DISPERSAL
AB As part of a study to develop recommendations for non-indigenous species (NIS) monitoring in Great Lakes areas at risk of invasion, we conducted intensive sampling in the Duluth-Superior Harbor and lower St. Louis River in 2005 and 2006. Of the similar to 240 benthic invertebrate taxa identified, 19 were non-indigenous, including 8 first detection records for this system: New Zealand mud snail Potamopyrgus antipodarum; African/Asian-origin cladoceran Daphnia lumholtzi; Eurasian-origin amphipod Echinogammarus ischnus; Eurasian-origin bivalves Dreissena bugensis, Pisidium henslowanum and Pisidium supinum; and possibly range expanding oligochaetes Paranais frici and Pristina acuminata. Dreissenids were by far the most abundant NIS. Several other NIS were also common, but others were detected in only a few of the >200 samples taken. Non-indigenous amphipods and Dreissena were most frequently detected in sweep net and colonization plate samples of littoral vegetation, while NIS oligochaetes, gastropods, and non-dreissenid bivalves were most frequently detected in ponar and bottom sled samples of sediments. Our findings confirm that this major shipping port remains a NIS "hotspot" and emphasize that regular surveys covering a range of habitats with multiple sampling gears and thorough taxonomic effort are needed to detect and monitor non-indigenous species. Published by Elsevier B.V. on behalf of International Association for Great Lakes Research.
C1 [Trebitz, Anett S.; West, Corlis W.; Hoffman, Joel C.; Kelly, John R.; Peterson, Gregory S.] US EPA, Natl Hlth & Environm Effects Res Lab, Mid Continent Ecol Div, Duluth, MN 55804 USA.
[Grigorovich, Igor A.] Wilson Environm Labs, Duluth, MN 55804 USA.
RP Trebitz, AS (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Mid Continent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA.
EM trebitz.anett@epa.gov; hoffman.joel@epa.gov; kelly.johnr@epa.gov;
peterson.greg@epa.gov; igrigorovich@gmail.com
FU U.S. Environmental Protection Agency
FX Charlie Butterworth, Tim Corry, Sam Miller, Mario Picinich, Brian
Sederberg, and Jon Van Alstine assisted with the field work. The map was
produced by Matthew Starry. We thank Tim Dawson and staff at Wilson
Environmental Laboratories for conducting sample picking and counting;
staff taxonomists were Kevin Stroom and John Sandberg in addition to
co-author Grigorovich. Outside taxonomic experts consulted for quality
assurance checks and difficult specimens were Dr. Gerry Mackie
(University of Guelph) and Drs. Mary Balcer and Kurt Schmude (University
of Wisconsin - Superior). Although this work was fully funded by the
U.S. Environmental Protection Agency, the views expressed in this
article are those of the authors and do not necessarily reflect the
views or policies of the Agency.
NR 53
TC 8
Z9 8
U1 2
U2 21
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0380-1330
J9 J GREAT LAKES RES
JI J. Gt. Lakes Res.
PD DEC
PY 2010
VL 36
IS 4
BP 747
EP 756
DI 10.1016/j.jglr.2010.09.003
PG 10
WC Environmental Sciences; Limnology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA 692QN
UT WOS:000285170300018
ER
PT J
AU Jefferson, WN
AF Jefferson, Wendy N.
TI Adult Ovarian Function Can Be Affected by High Levels of Soy
SO JOURNAL OF NUTRITION
LA English
DT Article; Proceedings Paper
CT Workshop on Soy Summit Exploration of the Nutrition and Health Effects
of Whole Soy
CY SEP 21-22, 2009
CL Columbia Univ, Inst Human Nutr, New York, NY
HO Columbia Univ, Inst Human Nutr
ID ESTROGEN-RECEPTOR-BETA; PREMENOPAUSAL WOMEN; POSTMENOPAUSAL WOMEN;
JAPANESE WOMEN; PHYTOESTROGENS; FOODS; ISOFLAVONES; INFERTILITY;
RESPONSES; SOYBEANS
AB Ovarian function in adults is controlled by hormones circulating in the body The primary hormone responsible for cyclicity in animals and humans is estrogen Estrogen is mostly produced in the ovary and enters the circulation where it then signals the brain for a response The parts of the brain that controls reproductive hormones are the hypothalamus and anterior pituitary Estrogen stimulates the hypothalamus to produce gonadotropin releasing hormone which in turn signals the anterior pituitary to produce follicle stimulating hormone and luteinizing hormone These hormones enter the circulation and signal the ovary to ovulate Substances with estrogenic activity can potentially interfere with this signaling if levels of activity are sufficient to cause a response Soy foods contain estrogenic substances called phytoestrogens The predominant phytoestrogens found in soy are genistein and daidzein The female reproductive system is dependent on hormones for proper function and phytoestrogens at very high levels can interfere with this process This paper summarizes the literature on adult soy consumption and its effect on ovarian function J Nutr 140 2322S-2325S 2010
C1 Natl Inst Environm Hlth Sci, Reprod & Dev Toxicol Lab, Res Triangle Pk, NC USA.
RP Jefferson, WN (reprint author), Natl Inst Environm Hlth Sci, Reprod & Dev Toxicol Lab, Res Triangle Pk, NC USA.
NR 31
TC 8
Z9 8
U1 1
U2 9
PU AMER SOC NUTRITIONAL SCIENCE
PI BETHESDA
PA 9650 ROCKVILLE PIKE, RM L-2407A, BETHESDA, MD 20814 USA
SN 0022-3166
J9 J NUTR
JI J. Nutr.
PD DEC
PY 2010
VL 140
IS 12
BP 2322S
EP 2325S
DI 10.3945/jn.110.123802
PG 4
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA 692AG
UT WOS:000285123300033
PM 20980642
ER
PT J
AU McGarvey, DJ
Johnston, JM
Barber, MC
AF McGarvey, Daniel J.
Johnston, John M.
Barber, M. Craig
TI Predicting fish densities in lotic systems: a simple modeling approach
SO JOURNAL OF THE NORTH AMERICAN BENTHOLOGICAL SOCIETY
LA English
DT Article
DE body mass vs abundance; self-thinning relationship; trophic transfer
efficiency; scalable model; simple vs complex models; macroecology;
primary production; stream ecology
ID TROPHIC TRANSFER EFFICIENCY; STREAM-LIVING SALMONIDS; SELF-THINNING
RULE; BODY-SIZE; POPULATION-DENSITY; SMALLMOUTH BASS; COMMUNITY
STRUCTURE; COLORADO SQUAWFISH; TROUT ABUNDANCE; TERRITORY SIZE
AB Fish density models are essential tools for fish ecologists and fisheries managers. However, applying these models can be difficult because of high levels of model complexity and the large number of parameters that must be estimated. We designed a simple fish density model and tested whether it could predict fish densities in lotic systems with meaningful levels of accuracy and precision. We built our 6-parameter model on 2 key assumptions: 1) fish population density is a power function of mean body mass (i.e., the self-thinning relationship), and 2) energetic resources are transferred from lower to higher trophic levels at a nearly constant rate (i.e., trophic transfer efficiency). We estimated the self-thinning and trophic transfer efficiency parameters by randomly sampling from values reported in the primary literature. Remaining parameters were net primary production, trophic level, the production:biomass ratio, and mean body mass. We used empirical parameter estimates and fish density estimates to test the model in 4 warm-water and 4 cold-water systems. Model accuracy was high in 3 test systems (deviations between the model-predicted densities and empirically observed densities <30%), moderate in 3 test systems (deviations 75-111%), and low in 2 systems (deviations >150%). Model precision was low (e.g., the interquartile ranges of model-predicted densities encompassed similar to 1 order of magnitude), but appropriate for predicting fish densities at coarse spatial and temporal scales. We concluded that the model is a potentially useful and efficient tool, and we provide recommendations for applying the model. In particular, we emphasize that the model is scalable, and therefore, well-suited for estimating fish densities at large spatial scales. We also point out that the model is a carrying capacity model, and therefore, can be used to predict fish densities in undisturbed systems or to approximate reference conditions.
C1 [McGarvey, Daniel J.; Johnston, John M.; Barber, M. Craig] US EPA, Ecosyst Res Div, Athens, GA 30605 USA.
RP McGarvey, DJ (reprint author), US EPA, Ecosyst Res Div, Athens, GA 30605 USA.
EM mcgar002@gmail.com; johnston.johnm@epa.gov; barber.craig@epa.gov
RI McGarvey, Daniel/A-7725-2009
NR 110
TC 6
Z9 6
U1 1
U2 27
PU NORTH AMER BENTHOLOGICAL SOC
PI LAWRENCE
PA 1041 NEW HAMSPHIRE STREET, LAWRENCE, KS 66044 USA
SN 0887-3593
J9 J N AM BENTHOL SOC
JI J. N. Am. Benthol. Soc.
PD DEC
PY 2010
VL 29
IS 4
BP 1212
EP 1227
DI 10.1899/09-094.1
PG 16
WC Ecology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA 676EB
UT WOS:000283891800003
ER
PT J
AU Ren, RQ
Willis, MS
Fedoriw, Y
AF Ren, Rongqin
Willis, Monte S.
Fedoriw, Yuri
TI Episodic Fever and Neutropenia in a 22-Year-Old Male
SO LABMEDICINE
LA English
DT Editorial Material
DE Genetics; Hematology; Hematopathology; Clinical Pathology; Chemistry
ID SEVERE CONGENITAL NEUTROPENIA; UNFOLDED PROTEIN RESPONSE; ONSET CYCLIC
NEUTROPENIA; BREAST-CANCER PATIENTS; X-LINKED NEUTROPENIA; INDUCED
AGRANULOCYTOSIS; FOLLOW-UP; LEVAMISOLE; MUTATIONS; ELASTASE
C1 [Willis, Monte S.; Fedoriw, Yuri] Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC 27515 USA.
[Ren, Rongqin] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
RP Fedoriw, Y (reprint author), Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC 27515 USA.
NR 42
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CLINICAL PATHOLOGY
PI CHICAGO
PA 2100 W HARRISON ST, CHICAGO, IL 60612 USA
SN 0007-5027
J9 LABMEDICINE
JI Labmedicine
PD DEC
PY 2010
VL 41
IS 12
BP 708
EP 712
DI 10.1309/LM6BB0G1VYT0SFNF
PG 5
WC Medical Laboratory Technology
SC Medical Laboratory Technology
GA 686FH
UT WOS:000284681700001
ER
PT J
AU Parks, CG
Biagini, RE
Cooper, GS
Gilkeson, GS
Dooley, MA
AF Parks, C. G.
Biagini, R. E.
Cooper, G. S.
Gilkeson, G. S.
Dooley, M. A.
TI Total serum IgE levels in systemic lupus erythematosus and associations
with childhood onset allergies
SO LUPUS
LA English
DT Article
DE allergy; atopy; autoantibodies; autoimmunity; hygiene hypothesis;
immunoglobulins; nephritis; population-based; systemic lupus
erythematosus
ID IMMUNOGLOBULIN-E LEVELS; C-REACTIVE PROTEIN; VITAMIN-D;
AUTOIMMUNE-DISEASES; HYGIENE HYPOTHESIS; ATOPIC DISORDERS; RISK-FACTORS;
EARLY-LIFE; POPULATION; ASTHMA
AB Elevated serum IgE has been described in systemic lupus erythematosus (SLE), but associations with disease risk and characteristics remain unresolved. We assessed total serum IgE levels and atopy (IgE > 100 IU/ml) in recently diagnosed SLE patients (n = 228) compared with population controls (n = 293) and in relation to disease activity, autoantibodies, clinical features, total immunoglobulins, C-reactive protein, and allergy history. Multivariate models estimated determinants of IgE and atopy in patients and controls, and associations of SLE with allergy and atopy. Total IgE levels were higher in patients than controls (median = 42 vs. 29 IU/ml); 32% of patients and 25% of controls were atopic (p = 0.06). IgE levels were significantly higher in non-Whites and patients reporting childhood onset (< 18 years) asthma and hives, and in controls reporting childhood asthma, hay fever, eczema, and adult onset hives. After accounting for racial differences, atopy was not associated with SLE, nephritis, or other clinical and laboratory parameters. In sum, our findings provide limited evidence of a direct association between total serum IgE and SLE overall or with other disease characteristics after adjusting for demographic characteristics and allergy history. Future studies may want to explore potentially shared risk factors for development of allergy, atopy, and SLE. Lupus (2010) 19, 1614-1622.
C1 [Parks, C. G.] NIEHS, Epidemiol Branch, NIH, Dept Hlth & Human Serv, Durham, NC USA.
[Biagini, R. E.] NIOSH, Ctr Dis Control & Prevent, Dept Hlth & Human Serv, Cincinnati, OH 45226 USA.
[Cooper, G. S.] US EPA, Washington, DC 20460 USA.
[Gilkeson, G. S.] Med Univ S Carolina, Charleston, SC 29425 USA.
[Dooley, M. A.] Univ N Carolina, Div Rheumatol, Chapel Hill, NC USA.
RP Parks, CG (reprint author), NIEHS, Epidemiol Branch, A3-05,POB 12233, Res Triangle Pk, NC 27599 USA.
EM Parks1@mail.nih.gov
OI Parks, Christine/0000-0002-5734-3456
FU NIH; National Institute of Environmental Health Sciences; National
Institute for Occupational Safety and Health; NIOSH [Y1-ES-0001-Clinical
Immunotoxicity]; National Institute of Environmental Health Sciences
(NIEHS) [Y1-ES-0001-Clinical Immunotoxicity]
FX This work was supported in part by the intramural research program of
the NIH, National Institute of Environmental Health Sciences, by the
National Institute for Occupational Safety and Health, and by an
interagency agreement between NIOSH and National Institute of
Environmental Health Sciences (NIEHS) (grant number Y1-ES-0001-Clinical
Immunotoxicity).
NR 48
TC 12
Z9 12
U1 0
U2 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0961-2033
J9 LUPUS
JI Lupus
PD DEC
PY 2010
VL 19
IS 14
BP 1614
EP 1622
DI 10.1177/0961203310379870
PG 9
WC Rheumatology
SC Rheumatology
GA 685IA
UT WOS:000284621200005
PM 20937624
ER
PT J
AU Bailey, KA
Hester, SD
Knapp, GW
Owen, RD
Thai, SF
AF Bailey, Kathryn A.
Hester, Susan D.
Knapp, Geremy W.
Owen, Russell D.
Thai, Sheau-Fung
TI Gene Expression of Normal Human Epidermal Keratinocytes Modulated by
Trivalent Arsenicals
SO MOLECULAR CARCINOGENESIS
LA English
DT Article
DE carcinogenesis; arsenic; gene expression; keratinocytes
ID RAT-LIVER CYTOSOL; OXIDATIVE DNA-DAMAGE; MALE F344 RATS; DIMETHYLARSINIC
ACID; ANIMAL-MODEL; MOLECULAR-MECHANISMS; GROWTH-FACTORS; IN-VITRO;
METHYLATED ARSENICALS; CHRONIC STIMULATION
AB Chronic exposure to inorganic arsenic (iAs) is associated with the development of benign and malignant human skin lesions including nonmelanoma skin cancers. The precise arsenical form(s) responsible for this carcinogenic effect are unknown, although trivalent inorganic arsenic (iAs(III)) and two of its toxic metabolites, monomethylarsonous acid (MMA(III)) and methylarsinous acid (DMA(III)), are attractive candidates. In an effort to better understand and compare their toxic effects in the skin, we compared the global gene expression profiles of normal human epidermal keratinocytes (NHEKs) exposed to varying noncytotoxic/slightly cytotoxic concentrations of iAs(III), MMA(III), and DMA(III) for 24h. Exposure to each arsenical treatment group exhibited a dose effect in the number of altered genes and the magnitude of expression change in NHEKs. The most significant gene expression changes associated with iAs(III) and MMA(III) exposure were consistent with several key events believed to be important to As-driven skin carcinogenesis, namely induction of oxidative stress, increased transcript levels of keratinocyte growth factors, and modulation of MAPK and NF-kappa B pathways. At both comparable arsenical concentrations and comparable NHEK toxicity, greater potential carcinogenic effects were observed in MMA(III)-exposed NHEKs than those exposed to iAs(III), including involvement of more proinflammatory signals and increased transcript levels of more growth factor genes. In contrast, none of these above-mentioned transcriptional trends were among the most significantly altered functions in the DMA(III) treatment group. This study suggests the relative capacity of each of the tested arsenicals to drive suspected key events in As-mediated skin carcinogenesis is MMA(III) > iAs(III) with little contribution from DMA(III). (C) 2010 Wiley-Liss, Inc.
C1 [Bailey, Kathryn A.; Hester, Susan D.; Knapp, Geremy W.; Owen, Russell D.; Thai, Sheau-Fung] US EPA, Res Triangle Pk, NC 27711 USA.
RP Thai, SF (reprint author), 109 TW Alexander Dr, Res Triangle Pk, NC 27709 USA.
NR 92
TC 11
Z9 11
U1 0
U2 6
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0899-1987
J9 MOL CARCINOGEN
JI Mol. Carcinog.
PD DEC
PY 2010
VL 49
IS 12
BP 981
EP 998
DI 10.1002/mc.20677
PG 18
WC Biochemistry & Molecular Biology; Oncology
SC Biochemistry & Molecular Biology; Oncology
GA 687OZ
UT WOS:000284789100001
PM 20886546
ER
PT J
AU Whitehead, A
Triant, DA
Champlin, D
Nacci, D
AF Whitehead, A.
Triant, D. A.
Champlin, D.
Nacci, D.
TI Comparative transcriptomics implicates mechanisms of evolved pollution
tolerance in a killifish population
SO MOLECULAR ECOLOGY
LA English
DT Article
DE adaptation; comparative biology; ecotoxicology; natural selection and
contemporary evolution; transcriptomics
ID ARYL-HYDROCARBON RECEPTOR; FISH FUNDULUS-HETEROCLITUS; GENE-EXPRESSION
PROFILES; MESSENGER-RNA EXPRESSION; HYPERTROPHIC CARDIOMYOPATHY; DILATED
CARDIOMYOPATHY; ATLANTIC KILLIFISH; NITRIC-OXIDE; AH RECEPTOR;
2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TOXICITY
AB Wild populations of the killifish Fundulus heteroclitus resident in heavily contaminated North American Atlantic coast estuaries have recently and independently evolved dramatic, heritable, and adaptive pollution tolerance. We compared physiological and transcriptome responses to embryonic polychlorinated biphenyl (PCB) exposures between one tolerant population and a nearby sensitive population to gain insight into genomic, physiological and biochemical mechanisms of evolved tolerance in killifish, which are currently unknown. The PCB exposure concentrations at which developmental toxicity emerged, the range of developmental abnormalities exhibited, and global as well as specific gene expression patterns were profoundly different between populations. In the sensitive population, PCB exposures produced dramatic, dose-dependent toxic effects, concurrent with the alterations in the expression of many genes. For example, PCB-mediated cardiovascular system failure was associated with the altered expression of cardiomyocyte genes, consistent with sarcomere mis-assembly. In contrast, genome-wide expression was comparatively refractory to PCB induction in the tolerant population. Tolerance was associated with the global blockade of the aryl hydrocarbon receptor (AHR) signalling pathway, the key mediator of PCB toxicity, in contrast to the strong dose-dependent up-regulation of AHR pathway elements observed in the sensitive population. Altered regulation of signalling pathways that cross-talk with AHR was implicated as one candidate mechanism for the adaptive AHR signalling repression and the pollution tolerance that it affords. In addition to revealing mechanisms of PCB toxicity and tolerance, this study demonstrates the value of comparative transcriptomics to explore molecular mechanisms of stress response and evolved adaptive differences among wild populations.
C1 [Whitehead, A.] Louisiana State Univ, Dept Biol Sci, Baton Rouge, LA 70803 USA.
[Triant, D. A.] Univ Virginia, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA.
[Champlin, D.; Nacci, D.] US EPA, Off Res & Dev, Atlantic Ecol Div, Natl Hlth & Environm Effects Res Lab, Narragansett, RI 02882 USA.
RP Whitehead, A (reprint author), Louisiana State Univ, Dept Biol Sci, 202 Life Sci Bldg, Baton Rouge, LA 70803 USA.
EM andreww@lsu.edu
RI Whitehead, Andrew/G-2122-2012
FU National Science Foundation [BES-0652006]; U.S. Environmental Protection
Agency; Office of Research and Development; National Health and
Environmental Effects Research Laboratory; Atlantic Ecology Division
FX We appreciate the helpful advice from reviewers of early drafts,
including Dina Proestou (U.S. Environmental Protection Agency), John
Battista (Louisiana State University) and Patrick Flight (Brown
University). This is contribution number AED-10-041 of the U.S.
Environmental Protection Agency, Office of Research and Development,
National Health and Environmental Effects Research Laboratory, Atlantic
Ecology Division, which partially supported this research. This
manuscript has been reviewed and approved for publication by the U. S.
EPA. Approval does not signify that the contents necessarily reflect the
views and policies of the U. S. EPA. Mention of trade names, products,
or services does not convey and should not be interpreted as conveying,
official U. S. EPA approval, endorsement, or recommendation. Funding for
some of this project was provided by the National Science Foundation
grant BES-0652006 to AW. The funders had no role in study design, data
collection and analysis, decision to publish or preparation of the
manuscript.
NR 108
TC 43
Z9 44
U1 11
U2 65
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0962-1083
J9 MOL ECOL
JI Mol. Ecol.
PD DEC
PY 2010
VL 19
IS 23
BP 5186
EP 5203
DI 10.1111/j.1365-294X.2010.04829.x
PG 18
WC Biochemistry & Molecular Biology; Ecology; Evolutionary Biology
SC Biochemistry & Molecular Biology; Environmental Sciences & Ecology;
Evolutionary Biology
GA 682UJ
UT WOS:000284428200010
PM 20874759
ER
PT J
AU DeMarini, DM
De Flora, S
AF DeMarini, David M.
De Flora, Silvio
TI What's in a name? The argument for changing the name of IAEMS and its
affiliated societies
SO MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
LA English
DT Editorial Material
DE IAEMS; Environmental mutagenesis; Genomics; Genetic toxicology;
Toxicogenomics
ID ENVIRONMENTAL GENOMICS
AB We identify trends over the past decades in membership in societies affiliated with the International Association of Environmental Mutagen Societies (IAEMS), and we also highlight findings in a recent review by Claxton et al. [Environ Health Perspect, in press] regarding the numbers of papers published per year using genetic toxicology assays. These analyses reveal a decline or at best a static level of membership in IAEMS-affiliated societies, as well as a decline in the number of papers published per year using genetic toxicology assays with the exception of those using comet assays, which already have begun to plateau. In contrast, toxicogenomics and computational toxicology are becoming increasingly prominent relative to environmental mutagenesis research in most research institutes, reflecting the ascendancy of these areas of environmental toxicology. We conclude that changing the name of IAEMS and its affiliated societies to reflect these changes might enhance membership and publication by welcoming a broader range of scientists into these societies. Although various names are possible, we think that changing the name of these societies to "Environmental Genomics Society" may help to make our societies more attractive to a broader range of scientists, resulting in an increase in membership and an acceleration of the incorporation of genomic methods into environmental research. Published by Elsevier B.V.
C1 [DeMarini, David M.] US EPA, Res Triangle Pk, NC 27711 USA.
[De Flora, Silvio] Univ Genoa, Dept Hlth Sci, I-16126 Genoa, Italy.
RP DeMarini, DM (reprint author), US EPA, B105-03, Res Triangle Pk, NC 27711 USA.
EM demarini.david@epa.gov
NR 7
TC 1
Z9 1
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1383-5742
J9 MUTAT RES-REV MUTAT
JI Mutat. Res.-Rev. Mutat. Res.
PD DEC
PY 2010
VL 705
IS 3
BP 201
EP 204
DI 10.1016/j.mrrev.2010.09.001
PG 4
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
GA 701HF
UT WOS:000285808300005
PM 20850562
ER
PT J
AU Dieleman, WIJ
Luyssaert, S
Rey, A
De Angelis, P
Barton, CVM
Broadmeadow, MSJ
Broadmeadow, SB
Chigwerewe, KS
Crookshanks, M
Dufrene, E
Jarvis, PG
Kasurinen, A
Kellomaki, S
Le Dantec, V
Liberloo, M
Marek, M
Medlyn, B
Pokorny, R
Scarascia-Mugnozza, G
Temperton, VM
Tingey, D
Urban, O
Ceulemans, R
Janssens, IA
AF Dieleman, W. I. J.
Luyssaert, S.
Rey, A.
De Angelis, P.
Barton, C. V. M.
Broadmeadow, M. S. J.
Broadmeadow, S. B.
Chigwerewe, K. S.
Crookshanks, M.
Dufrene, E.
Jarvis, P. G.
Kasurinen, A.
Kellomaki, S.
Le Dantec, V.
Liberloo, M.
Marek, M.
Medlyn, B.
Pokorny, R.
Scarascia-Mugnozza, G.
Temperton, V. M.
Tingey, D.
Urban, O.
Ceulemans, R.
Janssens, I. A.
TI Soil [N] modulates soil C cycling in CO2-fumigated tree stands: a
meta-analysis
SO PLANT CELL AND ENVIRONMENT
LA English
DT Article
DE [CO2] enrichment; C sequestration; fine root production; microbial
respiration; N fertilization; root biomass
ID ELEVATED ATMOSPHERIC CO2; NITROGEN DEPOSITION; CARBON STORAGE; MICROBIAL
COMMUNITY; FOREST ECOSYSTEMS; PINUS-SYLVESTRIS; PLANT-RESPONSES;
ORGANIC-MATTER; CLIMATE-CHANGE; TEMPERATE
AB Under elevated atmospheric CO2 concentrations, soil carbon (C) inputs are typically enhanced, suggesting larger soil C sequestration potential. However, soil C losses also increase and progressive nitrogen (N) limitation to plant growth may reduce the CO2 effect on soil C inputs with time. We compiled a data set from 131 manipulation experiments, and used meta-analysis to test the hypotheses that: (1) elevated atmospheric CO2 stimulates soil C inputs more than C losses, resulting in increasing soil C stocks; and (2) that these responses are modulated by N. Our results confirm that elevated CO2 induces a C allocation shift towards below-ground biomass compartments. However, the increased soil C inputs were offset by increased heterotrophic respiration (Rh), such that soil C content was not affected by elevated CO2. Soil N concentration strongly interacted with CO2 fumigation: the effect of elevated CO2 on fine root biomass and -production and on microbial activity increased with increasing soil N concentration, while the effect on soil C content decreased with increasing soil N concentration. These results suggest that both plant growth and microbial activity responses to elevated CO2 are modulated by N availability, and that it is essential to account for soil N concentration in C cycling analyses.
C1 [Dieleman, W. I. J.; Luyssaert, S.; Liberloo, M.; Ceulemans, R.; Janssens, I. A.] Univ Antwerp, Dept Biol, Res Grp Plant & Vegetat Ecol, B-2610 Antwerp, Belgium.
[Rey, A.] CSIC, Estn Expt Zonas Aridas, Almeria, Spain.
[De Angelis, P.; Chigwerewe, K. S.; Scarascia-Mugnozza, G.] Univ Tuscia, Dept Forest Environm & Resources, I-01100 Viterbo, Italy.
[Barton, C. V. M.] State Forests New S Wales, Forest Res & Dev Div, Beecroft, NSW 2119, Australia.
[Broadmeadow, M. S. J.; Broadmeadow, S. B.] Forestry Commiss England, SE England Reg Off, Surrey GU10 4LF, England.
[Crookshanks, M.] Aalborg Hosp, Dept Life Sci, DK-9000 Aalborg, Denmark.
[Dufrene, E.] AgroParisTech, F-75231 Paris, France.
[Dufrene, E.] CNRS, F-91405 Orsay, France.
[Dufrene, E.] Univ Paris 11, Lab Ecol Syst, UMR 8079, F-91405 Orsay, France.
[Jarvis, P. G.; Temperton, V. M.] Univ Edinburgh, Sch GeoSci, Edinburgh EH9 3JU, Midlothian, Scotland.
[Kasurinen, A.] Univ Eastern Finland, Dept Environm Sci, FI-70211 Kuopio, Finland.
[Kellomaki, S.] Univ Joensuu, Fac Forestry, FIN-80101 Joensuu, Finland.
[Le Dantec, V.] Ctr Etud Spatiales BIOsphere, F-31401 Toulouse 4, France.
[Marek, M.; Pokorny, R.; Urban, O.] CzechGlobe, Ctr Global Climate Change Impact Studies, Brno 60300, Czech Republic.
[Medlyn, B.] Macquarie Univ, Dept Biol Sci, N Ryde, NSW 2109, Australia.
[Temperton, V. M.] Forschungszentrum Julich GmbH, Inst Chem & Dynam Geosphere ICG 3, D-52425 Julich, Germany.
[Tingey, D.] US EPA, Corvallis, OR 97333 USA.
[Luyssaert, S.] CEA CNRS UVSQ, LSCE IPSL, F-91191 Gif Sur Yvette, France.
RP Dieleman, WIJ (reprint author), Univ Antwerp, Dept Biol, Res Grp Plant & Vegetat Ecol, Univ Pl 1, B-2610 Antwerp, Belgium.
EM wouter.dieleman@ua.ac.be
RI Barton, Craig/B-7026-2008; Luyssaert, Sebastiaan/F-6684-2011; De
Angelis, Paolo/A-6863-2012; Urban, Otmar/J-7432-2012; Duroux,
Meg/D-1522-2009; Pokorny, Radek/D-8208-2014; Marek, Michal
V./D-4383-2014; Ceulemans, Reinhart/F-2109-2016; Rey, Ana/F-5791-2016;
Janssens, Ivan/P-1331-2014;
OI De Angelis, Paolo/0000-0001-8310-8831; Pokorny,
Radek/0000-0001-5121-6694; Rey, Ana/0000-0003-0394-101X; Janssens,
Ivan/0000-0002-5705-1787; Medlyn, Belinda/0000-0001-5728-9827;
Luyssaert, Sebastiaan/0000-0003-1121-1869
FU FWO; European Research Council (ERC); UA-Research Centre of Excellence
ECO
FX We thank L. E. Henry and K. Pregitzer for providing data, as well as C.
Korner for useful information about their experimental sites. Special
thanks go to the researchers of the ECOCRAFT [Framework programmes of
the EC (EC contracts within 5FP and 6FP, Environment and Research)] and
the EUROFACE projects, who provided the large number of data that formed
the foundation for this paper. M. L. is a postdoctoral research
associate of the Flemish Science Foundation FWO (Fonds Wetenschappelijk
onderzoek, FWO Vlaanderen). I.J. holds an FWO research grant, and S. L.
holds a European Research Council (ERC) grant. Part of this research has
been funded through the UA-Research Centre of Excellence ECO.
NR 63
TC 24
Z9 25
U1 4
U2 54
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0140-7791
J9 PLANT CELL ENVIRON
JI Plant Cell Environ.
PD DEC
PY 2010
VL 33
IS 12
BP 2001
EP 2011
DI 10.1111/j.1365-3040.2010.02201.x
PG 11
WC Plant Sciences
SC Plant Sciences
GA 679MW
UT WOS:000284166500001
PM 20573048
ER
PT J
AU Stark, JL
Mercier, KA
Mueller, GA
Acton, TB
Xiao, R
Montelione, GT
Powers, R
AF Stark, Jaime L.
Mercier, Kelly A.
Mueller, Geoffrey A.
Acton, Thomas B.
Xiao, Rong
Montelione, Gaetano T.
Powers, Robert
TI Solution structure and function of YndB, an AHSA1 protein from Bacillus
subtilis
SO PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
LA English
DT Article
DE NMR structure; YndB Bacillus subtilis; NMR ligand affinity screen; in
silico screen; chalcones; stress response; symbiotic relationship
ID PHOSPHATIDYLCHOLINE TRANSFER PROTEIN; AROMATIC POLYKETIDES; AUTOMATED
DOCKING; ATPASE ACTIVITY; BINDING DOMAIN; DRUG DISCOVERY;
CHEMICAL-SHIFT; NMR STRUCTURE; CELL BIOLOGY; ACTIVE-SITE
AB The solution structure of the Bacillus subtilis protein YndB has been solved using NMR to investigate proposed biological functions. The YndB structure exhibits the helix-grip fold, which consists of a beta-sheet with two small and one long alpha-helix, forming a hydrophobic cavity that preferentially binds lipid-like molecules. Sequence and structure comparisons with proteins from eukaryotes, prokaryotes, and archaea suggest that YndB is very similar to the eukaryote protein Aha1, which binds to the middle domain of Hsp90 and induces ATPase activity. On the basis of these similarities, YndB has been classified as a member of the activator of Hsp90 ATPase homolog 1-like protein (AHSA1) family with a function that appears to be related to stress response. An in silico screen of a compound library of similar to 18,500 lipids was used to identify classes of lipids that preferentially bind YndB. The in silico screen identified, in order of affinity, the chalcone/hydroxychalcone, flavanone, and flavone/flavonol classes of lipids, which was further verified by 2D H-1-N-15 HSQC NMR titration experiments with trans-chalcone, flavanone, flavone, and flavonol. All of these compounds are typically found in plants as precursors to various flavonoid antibiotics and signaling molecules. The sum of the data suggests an involvement of YndB with the stress response of B. subtilis to chalcone-like flavonoids released by plants due to a pathogen infection. The observed binding of chalcone-like molecules by YndB is likely related to the symbiotic relationship between B. subtilis and plants.
C1 [Stark, Jaime L.; Mercier, Kelly A.; Powers, Robert] Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA.
[Mercier, Kelly A.; Mueller, Geoffrey A.] Natl Inst Environm Hlth Sci, Struct Biol Lab, Durham, NC 27709 USA.
[Acton, Thomas B.; Xiao, Rong; Montelione, Gaetano T.] Rutgers State Univ, NE Struct Genom Consortium, Ctr Adv Biotechnol & Med, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA.
[Montelione, Gaetano T.] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Piscataway, NJ 08854 USA.
RP Powers, R (reprint author), Univ Nebraska, Dept Chem, 722 Hamilton Hall, Lincoln, NE 68588 USA.
EM rpowers3@unl.edu
OI Stark, Jaime/0000-0001-5456-4846
FU Protein Structure Initiative of the National Institutes of Health [U54
GM074958]; National Institute of Allergy and Infectious Diseases
Nebraska [R21AI081154]; NIH [RR015468-01]; Battelle (U.S. Department of
Energy Office of Biological and Environmental Research) [KP130103];
Tobacco Settlement Biomedical Research Development Fund; NIH; National
Institute of Environmental Health Sciences
FX Grant sponsor: Protein Structure Initiative of the National Institutes
of Health; Grant number: U54 GM074958; Grant sponsor: National Institute
of Allergy and Infectious Diseases Nebraska; Grant number: R21AI081154;
Grant sponsor: NIH; Grant number: RR015468-01; Grant sponsor: Battelle
(U.S. Department of Energy Office of Biological and Environmental
Research); Grant number: KP130103; Grant sponsors: Tobacco Settlement
Biomedical Research Development Fund, NIH (Intramural Research Program),
National Institute of Environmental Health Sciences
NR 84
TC 6
Z9 6
U1 0
U2 7
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0887-3585
J9 PROTEINS
JI Proteins
PD DEC
PY 2010
VL 78
IS 16
BP 3328
EP 3340
DI 10.1002/prot.22840
PG 13
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA 678CK
UT WOS:000284046400008
PM 20818668
ER
PT J
AU Kough, JL
AF Kough, John L.
TI Introduction: HESI Workshop on Evaluating Biological Variation in
Non-Transgenic Crops
SO REGULATORY TOXICOLOGY AND PHARMACOLOGY
LA English
DT Editorial Material
C1 US EPA, Biopesticides & Pollut Prevent Div, Off Pesticide Programs, Washington, DC 20460 USA.
RP Kough, JL (reprint author), US EPA, Biopesticides & Pollut Prevent Div, Off Pesticide Programs, Washington, DC 20460 USA.
EM kough.john@epa.gov
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0273-2300
J9 REGUL TOXICOL PHARM
JI Regul. Toxicol. Pharmacol.
PD DEC 1
PY 2010
VL 58
IS 3
SU 1
BP S1
EP S1
DI 10.1016/j.yrtph.2010.10.009
PG 1
WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology
SC Legal Medicine; Pharmacology & Pharmacy; Toxicology
GA 693GZ
UT WOS:000285213900001
PM 21081207
ER
PT J
AU Stanko, JP
Enoch, RR
Rayner, JL
Davis, CC
Wolf, DC
Malarkey, DE
Fenton, SE
AF Stanko, Jason P.
Enoch, Rolondo R.
Rayner, Jennifer L.
Davis, Christine C.
Wolf, Douglas C.
Malarkey, David E.
Fenton, Suzanne E.
TI Effects of prenatal exposure to a low dose atrazine metabolite mixture
on pubertal timing and prostate development of male Long-Evans rats
SO REPRODUCTIVE TOXICOLOGY
LA English
DT Article
DE Atrazine; Puberty; Prostate; Inflammation; Development; Rat;
Metabolites; Mixture
ID MAMMARY-GLAND DEVELOPMENT; FEMALE WISTAR RATS; THYROID-FUNCTION;
GESTATIONAL EXPOSURE; OVARIAN-FUNCTION; SPRAGUE-DAWLEY; UNITED-STATES;
IN-UTERO; PITUITARY; ANDROGEN
AB The present study examines the postnatal reproductive development of male rats following prenatal exposure to an atrazine metabolite mixture (AMM) consisting of the herbicide atrazine and its environmental metabolites diaminochlorotriazine hydroxyatrazine deethylatrazine and deisopropylatrazine Pregnant Long-Evans rats were treated by gavage with 0 09 0 87 or 8 73 mg AMM/kg body weight (BW) vehicle or 100 mg ATR/kg BW positive control on gestation days 15-19 Preputial separation was significantly delayed in 0 87 mg and 8 73 mg AMM-exposed males AMM-exposed males demonstrated a significant treatment-related increase in incidence and severity of inflammation in the prostate on postnatal day (PND) 120 A dose-dependent increase in epididymal fat masses and prostate foci were grossly visible in AMM-exposed offspring These results indicate that a short late prenatal exposure to mixture of chlorotriazine metabolites can cause chronic prostatitis in male LE rats The mode of action for these effects is presently unclear Published by Elsevier Inc
C1 [Stanko, Jason P.; Fenton, Suzanne E.] US EPA, Reprod Toxicol Div, ORD NHEERL, Res Triangle Pk, NC 27711 USA.
[Davis, Christine C.] US EPA, Hlth & Environm Impacts Div, OAR OAQPS, Res Triangle Pk, NC 27711 USA.
[Wolf, Douglas C.] US EPA, ORD, Res Triangle Pk, NC 27711 USA.
[Enoch, Rolondo R.] N Carolina Cent Univ, Dept Biol, Durham, NC 27707 USA.
[Rayner, Jennifer L.] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA.
[Fenton, Suzanne E.] NIEHS, NIH, NTP, CMPB, Res Triangle Pk, NC 27709 USA.
RP Fenton, SE (reprint author), NIEHS, NIH, NTP, CMPB, 111 TW Alexander Dr,MD E1 08, Res Triangle Pk, NC 27709 USA.
FU U S EPA/NCCU [CT829460]; North Carolina Central University Durham [NC
27707]; U S EPA NHEERL-DESE [CT826513]; University of North Carolina
Chapel Hill [NC 27599]; U S Environmental Protection Agency; Division of
Intramural Research of the NIH National Institute of Environmental
Health Sciences
FX Financial support for Rolondo Enoch by U S EPA/NCCU Cooperative Research
Training Grant No CT829460 North Carolina Central University Durham NC
27707 and for Jennifer Rayner by U S EPA NHEERL-DESE Cooperative
Training Agreement No CT826513 University of North Carolina Chapel Hill
NC 27599 The U S Environmental Protection Agency and the Division of
Intramural Research of the NIH National Institute of Environmental
Health Sciences have funded the studies in this document The contents do
not necessarily reflect the views of the Agency or the Institute nor
does mention of trade names or commercial products constitute
endorsement or recommendation for use Portions of these data were
presented at the Society for the Study of Reproduction meeting in San
Antonio TX July 2007
NR 46
TC 19
Z9 22
U1 2
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0890-6238
J9 REPROD TOXICOL
JI Reprod. Toxicol.
PD DEC
PY 2010
VL 30
IS 4
BP 540
EP 549
DI 10.1016/j.reprotox.2010.07.006
PG 10
WC Reproductive Biology; Toxicology
SC Reproductive Biology; Toxicology
GA 690VI
UT WOS:000285036300005
PM 20727709
ER
PT J
AU Dutta, TK
Chakraborty, J
Roy, M
Ghosal, D
Khara, P
Gunsalus, IC
AF Dutta, Tapan K.
Chakraborty, Joydeep
Roy, Madhumita
Ghosal, Debajyoti
Khara, Pratick
Gunsalus, Irwin C.
TI Cloning and characterization of a p-cymene monooxygenase from
Pseudomonas chlororaphis subsp aureofaciens
SO RESEARCH IN MICROBIOLOGY
LA English
DT Article
DE p-Cymene; Methyl hydroxylase; Monooxygenase; Non-heme di-iron enzyme;
Pseudomonas
ID ALKANE OMEGA-HYDROXYLASE; UPPER-PATHWAY OPERON; METHANE MONOOXYGENASE;
XYLENE MONOOXYGENASE; STRAIN; ENZYME; EXPRESSION; GENES; IDENTIFICATION;
DEGRADATION
AB p-Cymene monooxygenase is the enzyme system that catalyzes the hydroxylation of p-cymene to 4-isopropylbenzyl alcohol (p-cumic alcohol), the initial step in the assimilation of p-cymene by Pseudomonas chlororaphis subsp. aureofaciens. Cloning and sequencing of single NADH-dependent cytochrome c reductase gene (cymA) present in P chlororaphis subsp. aureofaciens was described earlier. In this study, analysis of the upstream sequence of cymA revealed two open reading frames, designated as cymB (495 bp) and cymM (1128 bp). Database searches with the cymM gene product showed similarity to integral-membrane di-iron enzymes, while that with cymB showed no significant similarity to other known proteins with the exception of epoxystyrene isomerases. Expression of all three components (cymMBA) in Escherichia coli confirmed its ability for p-cymene methyl group hydroxylation, while expression of cymM and cymA along with the partially truncated cymB gene showed an 85% decrease in the hydroxylation capacity. Our results suggest for the first time that the small protein, CymB, having no conserved domains in protein databases, is involved as enhancer/activator in p-cymene hydroxylation. (C) 2010 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
C1 [Dutta, Tapan K.; Chakraborty, Joydeep; Roy, Madhumita; Ghosal, Debajyoti; Khara, Pratick] Bose Inst, Dept Microbiol, Kolkata 700054, India.
[Dutta, Tapan K.; Gunsalus, Irwin C.] US EPA, Gulf Ecol Div, NHEERL, Gulf Breeze, FL 32561 USA.
RP Dutta, TK (reprint author), Bose Inst, Dept Microbiol, P-1-12 CIT Scheme VIIM, Kolkata 700054, India.
EM tapan@bic.boseinst.ernet.in
FU National Research Council, USA; Bose Institute, Kolkata, India
FX This manuscript is dedicated to the memory of I. C. Gunsalus (Gunny).
The authors wish to express appreciation to Professor K. P. Das and Dr.
Geoffrey Mattison for reviewing the manuscript. This work was supported
in part by a National Research Council Research Associate Award, USA
(T.K.D.) and Bose Institute, Kolkata, India.
NR 27
TC 3
Z9 3
U1 1
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0923-2508
EI 1769-7123
J9 RES MICROBIOL
JI Res. Microbiol.
PD DEC
PY 2010
VL 161
IS 10
BP 876
EP 882
DI 10.1016/j.resmic.2010.10.008
PG 7
WC Microbiology
SC Microbiology
GA 705RY
UT WOS:000286156800011
PM 21035544
ER
PT J
AU Hubbell, BJ
Crume, RV
Evarts, DM
Cohen, JM
AF Hubbell, Bryan J.
Crume, Richard V.
Evarts, Dale M.
Cohen, Jeff M.
TI Policy Monitor
SO REVIEW OF ENVIRONMENTAL ECONOMICS AND POLICY
LA English
DT Article
DE Q52; Q53; Q58
AB The management of air quality in the United States has evolved into a sophisticated array of rules, strategies, and initiatives since the landmark Clean Air Act (CAA) legislation of 1970 and the subsequent creation of the U.S. Environmental Protection Agency (EPA). In particular, the CAA Amendments of 1990 introduced several new programs that have substantially reshaped the nation's approach to air pollution control. This article describes the 1990 CAA Amendments, regulations issued by EPA following their passage, progress made in air quality management in the nearly twenty years since their enactment, and the likely future direction of U.S. air quality management programs at the federal level.
C1 [Hubbell, Bryan J.; Crume, Richard V.; Evarts, Dale M.] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
[Cohen, Jeff M.] US EPA, Off Atmospher Programs, Washington, DC 20004 USA.
RP Hubbell, BJ (reprint author), US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
EM hubbell.bryan@epa.gov; crume.rick@epa.gov; evarts.dale@epa.gov;
jeffcohen6@gmail.com
NR 20
TC 6
Z9 7
U1 1
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1750-6816
J9 REV ENV ECON POLICY
JI Rev. Env. Econ. Policy
PD WIN
PY 2010
VL 4
IS 1
BP 122
EP 138
DI 10.1093/reep/rep019
PG 17
WC Economics; Environmental Studies
SC Business & Economics; Environmental Sciences & Ecology
GA 549XY
UT WOS:000274089000008
ER
PT J
AU Kissinger, L
Lorenzana, R
Mittl, B
Lasrado, M
Iwenofu, S
Olivo, V
Helba, C
Capoeman, P
Williams, AH
AF Kissinger, Lon
Lorenzana, Roseanne
Mittl, Beth
Lasrado, Merwyn
Iwenofu, Samuel
Olivo, Vanessa
Helba, Cynthia
Capoeman, Pauline
Williams, Ann H.
TI Development of a Computer-Assisted Personal Interview Software System
for Collection of Tribal Fish Consumption Data
SO RISK ANALYSIS
LA English
DT Article
DE Fish consumption; software; survey; tribal
ID FOOD-FREQUENCY QUESTIONNAIRE; NATIVE-AMERICAN POPULATION;
CARDIOVASCULAR-DISEASE; EXPOSURE ASSESSMENT; PCB CONCENTRATIONS; DIETARY
EXPOSURE; ALASKA NATIVES; 24-HOUR RECALL; UNITED-STATES; RISK
AB The authors developed a computer-assisted personal interviewing (CAPI) seafood consumption survey tool from existing Pacific NW Native American seafood consumption survey methodology. The software runs on readily available hardware and software, and is easily configured for different cultures and seafood resources. The CAPI is used with a booklet of harvest location maps and species and portion size images. The use of a CAPI facilitates tribal administration of seafood consumption surveys, allowing cost-effective collection of scientifically defensible data and tribal management of data and data interpretation. Use of tribal interviewers reduces potential bias and discomfort that may be associated with nontribal interviewers. The CAPI contains a 24-hour recall and food frequency questionnaire, and assesses seasonal seafood consumption and temporal changes in consumption. EPA's methodology for developing ambient water quality criteria for tribes assigns a high priority to local data. The CAPI will satisfy this guidance objective. Survey results will support development of tribal water quality standards on their lands and assessment of seafood consumption-related contaminant risks and nutritional benefits. CAPI advantages over paper surveys include complex question branching without raising respondent burden, more complete interviews due to answer error and range checking, data transcription error elimination, printing and mailing cost elimination, and improved data storage. The survey instrument was pilot tested among the Quinault Nation in 2006.
C1 [Williams, Ann H.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Environm Publ Hlth Div, Chapel Hill, NC 27599 USA.
[Kissinger, Lon; Lorenzana, Roseanne] US EPA, Seattle, WA USA.
[Mittl, Beth; Lasrado, Merwyn; Olivo, Vanessa; Helba, Cynthia] WESTAT Corp, Rockville, MD 20850 USA.
[Iwenofu, Samuel; Capoeman, Pauline] Quinault Indian Nation, Taholah, WA USA.
RP Williams, AH (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Environm Publ Hlth Div, Chapel Hill, NC 27599 USA.
EM williams.annh@epa.gov
FU US EPA; EPA's Office of Research and Development, National Health and
Environmental Effects Research Laboratory, Environmental Public Health
Division, Epidemiology Branch
FX The EPA Environmental Public Health Division would like to thank its
contractor, Westat (Rockville, MD), for its role in developing a CAPI
for the collection of tribal fish consumption data. We would like to
acknowledge the U.S. Environmental Protection Agency, Office of Research
and Development, Office of Science Policy's Regional Applied Research
Effort program for leading the effort to develop this software. We would
like to acknowledge EPA's Office of Research and Development, National
Health and Environmental Effects Research Laboratory, Environmental
Public Health Division, Epidemiology Branch for its support of the
project. We also would like to remember Dr. Rebecca Calderon for her
support and encouragement in undertaking this project. Finally, we would
like to thank the Quinault Indian Nation located in Washington State for
its generous and enthusiastic participation in the pilot study.; The
information in this document has been funded by the US EPA. It has been
subjected to review by the National Health and Environmental Effects
Research Laboratory and approved for publication. Approval does not
signify that the contents reflect the views of the agency.
NR 51
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U1 2
U2 8
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0272-4332
J9 RISK ANAL
JI Risk Anal.
PD DEC
PY 2010
VL 30
IS 12
BP 1833
EP 1841
DI 10.1111/j.1539-6924.2010.01461.x
PG 9
WC Public, Environmental & Occupational Health; Mathematics,
Interdisciplinary Applications; Social Sciences, Mathematical Methods
SC Public, Environmental & Occupational Health; Mathematics; Mathematical
Methods In Social Sciences
GA 688RG
UT WOS:000284869100009
PM 20626689
ER
PT J
AU Lautier, A
Rosenbaum, RK
Margni, M
Bare, J
Roy, PO
Deschenes, L
AF Lautier, Anne
Rosenbaum, Ralph K.
Margni, Manuele
Bare, Jane
Roy, Pierre-Olivier
Deschenes, Louise
TI Development of normalization factors for Canada and the United States
and comparison with European factors
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Normalization factors; Life cycle assessment; Geographical comparisons;
Canada; United States; Uncertainty
ID CYCLE IMPACT ASSESSMENT; HUMAN TOXICITY; ECOTOXICITY; FIGURES
AB In Life Cycle Assessment (LCA) normalization calculates the magnitude of an impact (midpoint or endpoint) relative to the total effect of a given reference
The goal of this work is to calculate normalization factors for Canada and the US and to compare them with existing European normalization factors The differences between geographical areas were highlighted by identifying and comparing the main contributors to a given impact category in Canada the US and Europe This comparison verified that the main contributors in Europe and in the US are also present in the Canadian inventory It also showed that normalized profiles are highly dependent on the selected reference due to differences in the industrial and economic activities To meet practitioners needs. Canadian normalization factors have been calculated using the characterization factors from LUCAS (Canadian) IMPACT 2002+ (European) and TRACI (US) respectively The main sources of uncertainty related to Canadian NFs are data gaps (pesticides metals) and aggregated data (metals VOC) but the uncertainty related to CFs generally remains unknown A final discussion is proposed based on the comparison of resource extraction and resource consumption and raises the question of the legitimacy of defining a country by its geographical borders (C) 2010 Elsevier BV All rights reserved
C1 [Lautier, Anne; Margni, Manuele; Roy, Pierre-Olivier; Deschenes, Louise] Ecole Polytech, CIRAIG, Dept Chem Engn, Montreal, PQ H3C 3A7, Canada.
[Rosenbaum, Ralph K.] Tech Univ Denmark, Dept Engn Management, Sect Quantitat Sustainabil Assessment, DK-2800 Lyngby, Denmark.
[Bare, Jane] US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, Cincinnati, OH 45268 USA.
RP Lautier, A (reprint author), Ecole Polytech, CIRAIG, Dept Chem Engn, 2900 Edouard Montpetit,POB 6079,Stn Ctr Ville, Montreal, PQ H3C 3A7, Canada.
RI QSA, DTU/J-4787-2014;
OI Rosenbaum, Ralph/0000-0002-7620-1568
FU Industrial partners of the International Chair in Life Cycle Assessment
(a research unit of the CIRAIG)
FX The authors would like to acknowledge the financial support of the
industrial partners of the International Chair in Life Cycle Assessment
(a research unit of the CIRAIG)
NR 45
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Z9 23
U1 1
U2 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0048-9697
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD DEC 1
PY 2010
VL 409
IS 1
BP 33
EP 42
DI 10.1016/j.scitotenv.2010.09.016
PG 10
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 691HM
UT WOS:000285070900004
PM 20937518
ER
PT J
AU Boorman, GA
Wolf, DC
Francke-Carroll, S
Maronpot, RR
AF Boorman, Gary A.
Wolf, Douglas C.
Francke-Carroll, Sabine
Maronpot, Robert R.
TI Pathology Peer Review
SO TOXICOLOGIC PATHOLOGY
LA English
DT Editorial Material
DE toxicologic pathology; safety assessment; quality assurance
C1 [Boorman, Gary A.] Covance Inc, Vienna, VA USA.
[Wolf, Douglas C.] US EPA, Res Triangle Pk, NC 27711 USA.
[Francke-Carroll, Sabine] US FDA, College Pk, MD USA.
[Maronpot, Robert R.] Maronpot Consulting LLC, Raleigh, NC USA.
RP Boorman, GA (reprint author), Covance Inc, Vienna, VA USA.
NR 0
TC 3
Z9 3
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0192-6233
J9 TOXICOL PATHOL
JI Toxicol. Pathol.
PD DEC
PY 2010
VL 38
IS 7
BP 1009
EP 1010
DI 10.1177/0192623310385361
PG 2
WC Pathology; Toxicology
SC Pathology; Toxicology
GA 800QM
UT WOS:000293378600001
PM 21248323
ER
PT J
AU Chan, PC
Ramot, Y
Malarkey, DE
Blackshear, P
Kissling, GE
Travlos, G
Nyska, A
AF Chan, Po C.
Ramot, Yuval
Malarkey, David E.
Blackshear, Pamela
Kissling, Grace E.
Travlos, Greg
Nyska, Abraham
TI Fourteen-Week Toxicity Study of Green Tea Extract in Rats and Mice
SO TOXICOLOGIC PATHOLOGY
LA English
DT Article
DE green tea; toxicity; liver; nasal cavity
ID EPIGALLOCATECHIN GALLATE EGCG; ZERO DOSE CONTROL; INDUCED ASTHMA; WISTAR
RATS; METABOLIZING-ENZYMES; CAMELLIA-SINENSIS; GENE-EXPRESSION; NASAL
CAVITY; POLYPHENON-E; IN-VIVO
AB The toxicity of green tea extract (GTE) was evaluated in 14-week gavage studies in male and female F344/NTac rats and B6C3F1 mice at doses up to 1,000 mg/kg. In the rats, no treatment-related mortality was noted. In the mice, treatment-related mortality occurred in male and female mice in the 1,000 mg/kg dose groups. The cause of early deaths was likely related to liver necrosis. Treatment-related histopathological changes were seen in both species in the liver, nose, mesenteric lymph nodes, and thymus. In addition, in mice, changes were seen in the Peyer's patches, spleen, and mandibular lymph nodes. The no adverse effect level (NOAEL) for the liver in both species was 500 mg/kg. In the nose of rats, the NOAEL in males was 62.5 mg/kg, and in females no NOAEL was found. No NOAEL was found in the nose of female or male mice. The changes in the liver and nose were considered primary toxic effects of GTE, while the changes in other organs were considered to be secondary effects. The nose and liver are organs with high metabolic enzyme activity. The increased susceptibility of the nose and liver suggests a role for GTE metabolites in toxicity induction.
C1 [Nyska, Abraham] Toxicol Pathol, Timrat, Israel.
[Nyska, Abraham] Tel Aviv Univ, Sackler Sch Med, IL-36576 Tel Aviv, Israel.
[Chan, Po C.; Malarkey, David E.; Kissling, Grace E.; Travlos, Greg] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
[Ramot, Yuval] Hadassah Hebrew Univ Med Ctr, IL-91200 Jerusalem, Israel.
[Blackshear, Pamela] Integrated Lab Syst ILS Inc, Res Triangle Pk, NC USA.
RP Nyska, A (reprint author), DVM, Toxicol Pathologist, Haharuv 18,POB 184, IL-36576 Timrat, Israel.
EM anyska@bezeqint.net
FU NIH, National Institute of Environmental Health Sciences and Pathology
[N01-ES-55548 (HHSN291200555548C)]
FX This research was supported in part by the Intramural Research Program
of the NIH, National Institute of Environmental Health Sciences and
Pathology Support for the NIEHS, Contract # N01-ES-55548
(HHSN291200555548C).
NR 83
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U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0192-6233
EI 1533-1601
J9 TOXICOL PATHOL
JI Toxicol. Pathol.
PD DEC
PY 2010
VL 38
IS 7
BP 1070
EP 1084
DI 10.1177/0192623310382437
PG 15
WC Pathology; Toxicology
SC Pathology; Toxicology
GA 800QM
UT WOS:000293378600008
PM 20884815
ER
PT J
AU Wang, T
Jacobson-Kram, D
Pilaro, AM
Lapadula, D
Jacobs, A
Brown, P
Lipscomb, J
McGuinn, WD
AF Wang, Tao
Jacobson-Kram, David
Pilaro, Anne M.
Lapadula, Daniel
Jacobs, Abigail
Brown, Paul
Lipscomb, John
McGuinn, William David
TI ICH Guidelines: Inception, Revision, and Implications for Drug
Development
SO TOXICOLOGICAL SCIENCES
LA English
DT Editorial Material
ID TOXICITY; ASSAY; TRANSFORMATION; CARCINOGENS
C1 [Wang, Tao] Nova Pharmaceut Corp, Preclin Safety, Emeryville, CA 94608 USA.
[Jacobson-Kram, David; Pilaro, Anne M.; Jacobs, Abigail; Brown, Paul; McGuinn, William David] US FDA, Ctr Drug Evaluat & Res, Silver Spring, MD 20993 USA.
[Lapadula, Daniel] Novartis Pharmaceut, Preclin Safety, E Hanover, NJ 07936 USA.
[Lipscomb, John] US EPA, Natl Ctr Environm Assessment, Cincinnati, OH 45268 USA.
RP Wang, T (reprint author), Nova Pharmaceut Corp, Preclin Safety, 4560 Horton St,M-S 4-6, Emeryville, CA 94608 USA.
EM tao.wang@novartis.com
NR 16
TC 8
Z9 8
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
J9 TOXICOL SCI
JI Toxicol. Sci.
PD DEC
PY 2010
VL 118
IS 2
BP 356
EP 367
DI 10.1093/toxsci/kfq286
PG 12
WC Toxicology
SC Toxicology
GA 682WB
UT WOS:000284432600004
PM 20861066
ER
PT J
AU Duncan, KE
Ghio, AJ
Dailey, LA
Bern, AM
Gibbs-Flournoy, EA
Padilla-Carlin, DJ
Roggli, VL
Devlin, RB
AF Duncan, Kelly E.
Ghio, Andrew J.
Dailey, Lisa A.
Bern, Amy M.
Gibbs-Flournoy, Eugene A.
Padilla-Carlin, Danielle J.
Roggli, Victor L.
Devlin, Robert B.
TI Effect of Size Fractionation on the Toxicity of Amosite and Libby
Amphibole Asbestos
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE Libby amphibole; amosite; size fractionation; inflammation; oxidative
stress; airway epithelium
ID AIRWAY EPITHELIAL-CELLS; INDUCED PULMONARY-FIBROSIS; PARTICULATE MATTER;
DEPOSITION PATTERN; OXIDATIVE STRESS; UTAH VALLEY; CROCIDOLITE ASBESTOS;
NALP3 INFLAMMASOME; ALVEOLAR LEVEL; MONTANA
AB Abnormally high incidences of asbestos-related pulmonary disease have been reported in residents of Libby, Montana, because of occupational and environmental exposure to asbestos-contaminated vermiculite. The mechanism by which Libby amphibole (LA) causes pulmonary injury is not known. The purpose of this study is to compare the cellular stress responses induced in primary human airway epithelial cells (HAECs) exposed to a respirable size fraction (< 2.5 mu m) of Libby amphibole (LA(2.5)) to a similar size fraction of a reference amphibole sample amosite (AM(2.5)). HAEC were exposed to 0, 2.64, 13.2, or 26.4 mu g/cm(2) AM(2.5) or LA(2.5) or to equivalent doses of unfractionated amosite (AM) or LA for 2 or 24 h. Comparable messenger RNA transcript levels were observed for interleukin-8, cyclooxygenase-2, and heme oxygenase-1 in HAEC following a 24-h exposure to AM or LA. Conversely, exposure to AM(2.5) resulted in a 4- to 10-fold greater induction in these proinflammatory mediators compared with LA(2.5) after 24 h. Evaluation of the expression of 84 additional genes involved in cellular stress and toxicity responses confirmed a more robust response for AM(2.5) compared with LA(2.5) on an equal mass basis. Differences in total surface area (TSA) by gas adsorption, total particle number, or oxidant generation by the size-fractionated particles did not account for the observed difference in response. In summary, AM(2.5) and LA(2.5) are at least as potent in stimulating production of proinflammatory cytokines as unfractionated AM and LA. Interestingly, AM(2.5) was more potent at inducing a proinflammatory response than LA(2.5). This difference could not be explained by differences in mineral contamination between the two samples, TSA, or oxidant generation by the samples.
C1 [Duncan, Kelly E.] Univ N Carolina, Ctr Environm Med Asthma & Lung Biol, US EPA, Human Studies Facil, Chapel Hill, NC 27599 USA.
[Ghio, Andrew J.; Dailey, Lisa A.; Devlin, Robert B.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Bern, Amy M.] US EPA, Natl Enforcement Invest Ctr, Denver, CO 80225 USA.
[Gibbs-Flournoy, Eugene A.; Padilla-Carlin, Danielle J.] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27599 USA.
[Roggli, Victor L.] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA.
RP Duncan, KE (reprint author), Univ N Carolina, Ctr Environm Med Asthma & Lung Biol, US EPA, Human Studies Facil, 104 Mason Farm Rd, Chapel Hill, NC 27599 USA.
EM keduncan@email.unc.edu
FU U.S. Environmental Protection Agency (U.S. EPA) [CR83346301]; U.S. EPA
Region 8, Denver; U.S. EPA Office of Solid Waste and Emergency Response
and Office of Superfund Remediation and Technology Innovation
FX U.S. Environmental Protection Agency (U.S. EPA) cooperative agreement
(CR83346301); U.S. EPA Region 8, Denver, Libby Funds; U.S. EPA Office of
Solid Waste and Emergency Response and Office of Superfund Remediation
and Technology Innovation.
NR 62
TC 16
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U1 1
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD DEC
PY 2010
VL 118
IS 2
BP 420
EP 434
DI 10.1093/toxsci/kfq281
PG 15
WC Toxicology
SC Toxicology
GA 682WB
UT WOS:000284432600010
PM 20855422
ER
PT J
AU Jain, P
Townsend, TG
Tolaymat, TM
AF Jain, Pradeep
Townsend, Timothy G.
Tolaymat, Thabet M.
TI Steady-state design of horizontal systems for liquids addition at
bioreactor landfills
SO WASTE MANAGEMENT
LA English
DT Article
ID MUNICIPAL SOLID-WASTE; HYDRAULIC CONDUCTIVITY; LEACHATE RECIRCULATION;
REFUSE
AB The key parameters for designing a horizontal source (horizontal trenches, infiltration ponds, infiltration galleries or blankets) for steady state are the rate liquids can be added to the source, the lateral and vertical extents of the zone of impact of the source, and the liquids volume needed to wet the waste within the zone of impact at steady state. This paper presents charts that a designer can use to estimate these key parameters as functions of source dimensions, injection pressure, and municipal solid waste properties (porosity, hydraulic conductivity, and anisotropy) for designing a new or analyzing an existing horizontal source system for liquids addition to landfilled waste. SEEP/W was used to model liquids flow from a horizontal source in a range of conditions practically encountered for such systems. The governing equation (Richard's equation) and the boundary conditions were analyzed to formulate dimensionless variables by normalizing the design parameters (flow rate, injection pressure, the lateral zone of impact, injection pressure, and the added liquids volume) with the waste properties and source dimensions. The simulation results were transformed to the respective dimensionless forms and presented in design charts to estimate the key design parameters as functions of the source dimensions, waste properties, and injection pressure. The presentation of the modeling results in the dimensionless form facilitates their use beyond the conditions modeled. A solved example is presented to demonstrate the use of the design charts. The approach presented in the paper should be considered as approximate and designers should use their judgement and experience when using these charts for designing a horizontal liquids addition system for a specific site. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Townsend, Timothy G.] Univ Florida, Dept Environm Engn Sci, Gainesville, FL 32611 USA.
[Jain, Pradeep] Innovat Waste Consulting Serv LLC, Gainesville, FL 32605 USA.
[Tolaymat, Thabet M.] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA.
RP Townsend, TG (reprint author), Univ Florida, Dept Environm Engn Sci, POB 116450, Gainesville, FL 32611 USA.
EM pjain@iwcs.biz; ttown@ufl.edu; tolaymat.thabet@epa.gov
RI Townsend, Timothy/D-1981-2009
OI Townsend, Timothy/0000-0002-1222-0954
NR 28
TC 7
Z9 10
U1 0
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0956-053X
J9 WASTE MANAGE
JI Waste Manage.
PD DEC
PY 2010
VL 30
IS 12
BP 2560
EP 2569
DI 10.1016/j.wasman.2010.06.024
PG 10
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 676KF
UT WOS:000283909100019
PM 20729051
ER
PT J
AU Gentil, EC
Damgaard, A
Hauschild, M
Finnveden, G
Eriksson, O
Thorneloe, S
Kaplan, PO
Barlaz, M
Muller, O
Matsui, Y
Ii, R
Christensen, TH
AF Gentil, Emmanuel C.
Damgaard, Anders
Hauschild, Michael
Finnveden, Goran
Eriksson, Ola
Thorneloe, Susan
Kaplan, Pervin Ozge
Barlaz, Morton
Muller, Olivier
Matsui, Yasuhiro
Ii, Ryota
Christensen, Thomas H.
TI Models for waste life cycle assessment: Review of technical assumptions
SO WASTE MANAGEMENT
LA English
DT Review
ID DECISION-SUPPORT TOOL; POLLUTION-CONTROL RESIDUES; SOLID-WASTE;
ENVIRONMENTAL ASSESSMENT; MANAGEMENT-SYSTEMS; ORGANIC WASTE; PART 1;
INCINERATION; LCA; TECHNOLOGIES
AB A number of waste life cycle assessment (LCA) models have been gradually developed since the early 1990s, in a number of countries, usually independently from each other. Large discrepancies in results have been observed among different waste LCA models, although it has also been shown that results from different LCA studies can be consistent. This paper is an attempt to identify, review and analyse methodologies and technical assumptions used in various parts of selected waste LCA models. Several criteria were identified, which could have significant impacts on the results, such as the functional unit, system boundaries, waste composition and energy modelling. The modelling assumptions of waste management processes, ranging from collection, transportation, intermediate facilities, recycling, thermal treatment, biological treatment, and landfilling, are obviously critical when comparing waste LCA models.
This review infers that some of the differences in waste LCA models are inherent to the time they were developed. It is expected that models developed later, benefit from past modelling assumptions and knowledge and issues. Models developed in different countries furthermore rely on geographic specificities that have an impact on the results of waste LCA models. The review concludes that more effort should be employed to harmonise and validate non-geographic assumptions to strengthen waste LCA modelling. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Gentil, Emmanuel C.; Damgaard, Anders; Christensen, Thomas H.] Tech Univ Denmark, Dept Environm Engn, DK-2800 Lyngby, Denmark.
[Hauschild, Michael] Tech Univ Denmark, DTU Management Innovat & Sustainabil Grp, DK-2800 Lyngby, Denmark.
[Finnveden, Goran] Royal Inst Technol KTH, S-10044 Stockholm, Sweden.
[Eriksson, Ola] Univ Gavle, Dept Technol & Built Environm, S-80176 Gavle, Sweden.
[Thorneloe, Susan; Kaplan, Pervin Ozge] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
[Barlaz, Morton] NC State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA.
[Muller, Olivier] PricewaterhouseCoopers, F-92208 Neuilly Sur Seine, France.
[Matsui, Yasuhiro] Okayama Univ, Grad Sch Environm Sci, Okayama 7008530, Japan.
[Ii, Ryota] Pacific Consultants Co Ltd, Tama, Tokyo, Japan.
RP Christensen, TH (reprint author), Tech Univ Denmark, Dept Environm Engn, Bldg 115, DK-2800 Lyngby, Denmark.
EM thc@env.dtu.dk
RI Hauschild, Michael/G-4335-2011; Eriksson, Ola/J-1472-2012; QSA,
DTU/J-4787-2014; Hauschild, Michael /L-6059-2015; Damgaard,
Anders/H-9234-2012
OI Eriksson, Ola/0000-0002-5661-2917; Hauschild, Michael
/0000-0002-8331-7390; Damgaard, Anders/0000-0002-0452-1220
NR 67
TC 76
Z9 77
U1 3
U2 71
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0956-053X
J9 WASTE MANAGE
JI Waste Manage.
PD DEC
PY 2010
VL 30
IS 12
BP 2636
EP 2648
DI 10.1016/j.wasman.2010.06.004
PG 13
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 676KF
UT WOS:000283909100028
PM 20599370
ER
PT J
AU Boczek, LA
Johnson, CH
Meckes, MC
AF Boczek, Laura A.
Johnson, Clifford H.
Meckes, Mark C.
TI Chlorine Disinfection of Blended Municipal Wastewater Effluents
SO WATER ENVIRONMENT RESEARCH
LA English
DT Article
DE blending wastewater; chlorine disinfection blending effluents
ID MONOCHLORAMINE; INACTIVATION
AB Blending is used in the wastewater industry to manage wet-weather events. Wastewater is treated through primary clarification, with flows in excess of the hydraulic capacity of the secondary system being directed to effluent disinfection. Before disinfection, the primary clarified effluent is "blended'' with effluents that have been treated through the secondary system. The combined or "blended'' effluents are then disinfected before being discharged to receiving waters. This study evaluated the effectiveness of chlorine to disinfect blended effluents. Experiments were conducted at bench-scale on primary and secondary effluents and three ratios of primary to secondary effluent (1:9, 3:7, and 5:5) from three publicly owned treatment works. Results from this study found that blending 10% or more primary effluent with secondary reduces the efficacy of chlorine disinfection, and coliphage survived chlorine disinfection better than bacterial indicator organisms. A simple empirical model for predicting indicator organism densities following chlorine disinfection was developed using data from this research. Water Environ. Res., 82, 2373 (2010).
C1 [Boczek, Laura A.] US EPA, Cincinnati, OH 45268 USA.
RP Boczek, LA (reprint author), US EPA, 26 W Martin Luther King Dr,MS 387, Cincinnati, OH 45268 USA.
EM boczek.laura@epa.gov
FU U.S. Environmental Protection Agency (Washington, D.C.), through its
Office of Research and Development
FX The U.S. Environmental Protection Agency (Washington, D.C.), through its
Office of Research and Development, funded and managed, or partially
funded and collaborated in, the research described herein. It has been
subjected to the Agency's peer and administrative review and has been
approved for external publication. Any opinions expressed in this paper
are those of the author(s) and do not necessarily reflect the views of
the Agency; therefore, no official endorsement should be inferred. Any
mention of trade names or commercial products does not constitute
endorsement or recommendation for use.
NR 11
TC 0
Z9 0
U1 0
U2 4
PU WATER ENVIRONMENT FEDERATION
PI ALEXANDRIA
PA 601 WYTHE ST, ALEXANDRIA, VA 22314-1994 USA
SN 1061-4303
J9 WATER ENVIRON RES
JI Water Environ. Res.
PD DEC
PY 2010
VL 82
IS 12
BP 2373
EP 2379
DI 10.2175/106143010X12681059117175
PG 7
WC Engineering, Environmental; Environmental Sciences; Limnology; Water
Resources
SC Engineering; Environmental Sciences & Ecology; Marine & Freshwater
Biology; Water Resources
GA 687LY
UT WOS:000284781200009
PM 21214031
ER
PT J
AU Sifneos, JC
Herlihy, AT
Jacobs, AD
Kentula, ME
AF Sifneos, Jean C.
Herlihy, Alan T.
Jacobs, Amy D.
Kentula, Mary E.
TI Calibration of the Delaware Rapid Assessment Protocol to a Comprehensive
Measure of Wetland Condition
SO WETLANDS
LA English
DT Article
DE Double sampling; Inland Bays; Monitoring; Multiple regression; Nanticoke
ID WATERSHED SCALE; COMMON METRICS; USA; INTERCALIBRATION; EXPERIENCE;
MACROINVERTEBRATES; MARYLAND; FORESTS; EXAMPLE; RIVERS
AB The importance of monitoring and assessment to the management and protection of wetlands has become widely recognized. Wetland assessments are made at multiple intensity levels based on data quality, the application scale, available resources, and the level of effort involved in data collection. We used multiple regression to calibrate the output of a rapid assessment method to condition scores derived from a comprehensive assessment. Data collected at riverine, depression, and flat wetlands in the Nanticoke and Inland Bays watersheds of Delaware and Maryland were used to calibrate the Delaware Rapid Assessment Protocol to an Index of Wetland Condition (IWC) derived from hydrogeomorphic variables. The resulting calibrated rapid condition score was highly correlated with the intense IWC score in each wetland type (r = .88 for riverine, r = .82 for depressions and flats). The calibration methodology was also robust with respect to different statistical cutoff values and model selection methods. Our approach provides a quantitative alternative to using best professional judgment to determine rapid assessment scoring coefficients. Additionally, when rapid and comprehensive methods are correlated, double sampling, a statistical sampling method, can be used to increase the overall sample size resulting in either increased precision of condition estimates or lower sampling costs.
C1 [Sifneos, Jean C.] Oregon State Univ, Dept Stat, Corvallis, OR 97331 USA.
[Herlihy, Alan T.] Oregon State Univ, Dept Fisheries & Wildlife, Corvallis, OR 97331 USA.
[Jacobs, Amy D.] Delaware Dept Nat Resources & Environm Control, Dover, DE 19904 USA.
[Kentula, Mary E.] US EPA, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97333 USA.
RP Sifneos, JC (reprint author), Oregon State Univ, Dept Stat, Corvallis, OR 97331 USA.
EM sifneos@science.oregonstate.edu
FU U.S. Environmental Protection Agency (EPA) [RM-83143501]; National
Center for Environmental Research [RD834252-01]; Oregon State University
[CR-831682-01]
FX This work was funded by the U.S. Environmental Protection Agency (EPA)
through grant agreement RM-83143501, grant RD834252-01 from the National
Center for Environmental Research STAR Program, and cooperative
agreement CR-831682-01 with Oregon State University. This paper was
subjected to the EPA's peer and administrative review and approved for
publication. Mention of trade names or commercial products does not
constitute endorsement or recommendation for use. We thank John Van
Sickle for advice about model fitting and selection and Lisa Waigner for
helpful review comments on a previous draft of the manuscript. We are
particularly indebted to the people that assisted with data collection
as part of the assessment of wetland condition in the Nanticoke and
Inland Bays watersheds including Tim Adkins, Chris Bason, Lori Beasley,
Sara Bettlejewski, Stephanie Blades, David Bliel, Eric Beuhl, Chantal
Bouchard, EJ Chalabala, Griff Gilbert, Jim Green, Pat Groller, Jeff Lin,
Jessica Lister, John Martin, Erin McLaughlin, Evan Rehm, Bill Reybold,
Abby Rokosch, Tom Saladyga, Josh Thompson, Ted Weber, Christine
Whitcraft, Mike Yarcusko, and Michael Yost. Finally, we thank the editor
and two anonymous reviewers for thoughtful comments that helped improve
readability and focus of the manuscript.
NR 39
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Z9 8
U1 1
U2 14
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0277-5212
EI 1943-6246
J9 WETLANDS
JI Wetlands
PD DEC
PY 2010
VL 30
IS 6
BP 1011
EP 1022
DI 10.1007/s13157-010-0093-z
PG 12
WC Ecology; Environmental Sciences
SC Environmental Sciences & Ecology
GA 691QH
UT WOS:000285095400001
ER
PT J
AU Christensen, JR
Crumpton, WG
AF Christensen, Jay R.
Crumpton, William G.
TI Wetland Invertebrate Community Responses to Varying Emergent Litter in a
Prairie Pothole Emergent Marsh
SO WETLANDS
LA English
DT Article
DE Amphipods; Cattail hybrid; Detritus; Litter accumulation; Lemnids
ID FRESH-WATER MARSH; AQUATIC INVERTEBRATES; COASTAL WETLAND; INSECT
COMMUNITIES; FATHEAD MINNOWS; FISH PREDATION; LAKE-MICHIGAN; VEGETATION;
MACROINVERTEBRATES; ABUNDANCE
AB Plant litter produced in the interior of dense emergent stands may directly or indirectly influence invertebrate communities. Low litter may provide structure and refuge to invertebrates while high litter may displace vegetation and decrease oxygen concentration. Within an emergent stand, an edge-to-interior transect study and an interior litter treatment study were performed to investigate the impact of increasing litter densities on the invertebrate community. The interior had more litter, lemnid biomass, and hypoxia than the edge but did not differ in total invertebrate abundance. Low and moderate litter plots in the interior treatment study experienced higher lemnid biomass and greater total invertebrate abundance than the high litter plots, but the high litter plots were characterized by higher invertebrate diversity. There was a significant negative relationship between litter and invertebrate abundance in July and August. Invertebrate patterns were driven primarily by amphipod abundance and may be related to the use of lemnids as habitat. Hypoxic-tolerant and semi-aquatic taxa were associated with high litter, while several algal-feeding taxa were associated with the edge. High litter can reduce abundant invertebrates that support higher trophic levels and shift invertebrate communities. These findings underscore the importance of understanding long-term litter accumulation dynamics in wetland systems.
C1 [Christensen, Jay R.; Crumpton, William G.] Iowa State Univ, Dept Ecol Evolut & Organismal Biol, Ames, IA 50010 USA.
RP Christensen, JR (reprint author), US EPA, Natl Exposure Res Lab, Div Environm Sci, 944 E Harmon Ave, Las Vegas, NV 89119 USA.
EM christensen.jay@epamail.epa.gov
RI Williams, K/A-6361-2012
FU Graduate College; Environmental Science Program; Ecology and
Evolutionary Biology Interdisciplinary Program; Department of Ecology,
Evolution, and Organismal Biology of Iowa State University; United
States Environmental Protection Agency through its Office of Research
and Development
FX We thank the many undergraduate students for their hard work and the
owners of Anderson Lake for their support. We thank Philip Dixon, Greg
Stenback, and Maliha Nash for statistical consultation, the Brian Wilsey
lab for access to PCORD software and materials, and Arnold van der Valk,
John Downing, Philip Dixon, Greg Courtney, Amy Christensen, Jana
Stenback, Ann Pitchford, two anonymous reviewers, and editors for
comments on previous drafts. Financial support was provided by the
Graduate College, the Environmental Science Program, the Ecology and
Evolutionary Biology Interdisciplinary Program and the Department of
Ecology, Evolution, and Organismal Biology of Iowa State University. The
United States Environmental Protection Agency through its Office of
Research and Development partially funded and collaborated in the
research of Jay Christensen, and the work has been subjected to Agency
review and approved for publication.
NR 54
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U1 2
U2 20
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0277-5212
J9 WETLANDS
JI Wetlands
PD DEC
PY 2010
VL 30
IS 6
BP 1031
EP 1043
DI 10.1007/s13157-010-0109-8
PG 13
WC Ecology; Environmental Sciences
SC Environmental Sciences & Ecology
GA 691QH
UT WOS:000285095400003
ER
PT J
AU Elking, DM
Perera, L
Duke, R
Darden, T
Pedersen, LG
AF Elking, Dennis M.
Perera, Lalith
Duke, Robert
Darden, Thomas
Pedersen, Lee G.
TI Atomic Forces for Geometry-Dependent Point Multipole and Gaussian
Multipole Models
SO JOURNAL OF COMPUTATIONAL CHEMISTRY
LA English
DT Article
DE multipole; Gaussian multipole; force; torque; Wigner function
ID POLARIZABLE MOLECULAR-MECHANICS; INITIO QUANTUM-CHEMISTRY; DYNAMICS
SIMULATIONS; FLUCTUATING CHARGE; INTERMOLECULAR POTENTIALS; BIOMOLECULAR
SIMULATIONS; INTERACTION ENERGIES; WATER; FIELD; DIPOLE
AB In standard treatments of atomic multipole models, interaction energies, total molecular forces, and total molecular torques are given for multipolar interactions between rigid molecules. However, if the molecules are assumed to be flexible, two additional multipolar atomic forces arise because of (1) the transfer of torque between neighboring atoms and (2) the dependence of multipole moment on internal geometry (bond lengths, bond angles, etc.) for geometry-dependent multipole models. In this study, atomic force expressions for geometry-dependent multipoles are presented for use in simulations of flexible molecules. The atomic forces are derived by first proposing a new general expression for Wigner function derivatives partial derivative D(m'm)(l)/partial derivative Omega. The force equations can be applied to electrostatic models based on atomic point multipoles or Gaussian multipole charge density. Hydrogen-bonded dimers are used to test the intermolecular electrostatic energies and atomic forces calculated by geometry-dependent multipoles fit to the ab initio electrostatic potential. The electrostatic energies and forces are compared with their reference ab initio values. It is shown that both static and geometry-dependent multipole models are able to reproduce total molecular forces and torques with respect to ab initio, whereas geometry-dependent multipoles are needed to reproduce ab initio atomic forces. The expressions for atomic force can be used in simulations of flexible molecules with atomic multipoles. In addition, the results presented in this work should lead to further development of next generation force fields composed of geometry-dependent multipole models. (C) 2010 Wiley Periodicals, Inc. J Comput Chem 31: 2702-2713, 2010
C1 [Elking, Dennis M.; Perera, Lalith; Duke, Robert; Pedersen, Lee G.] Natl Inst Environm Hlth Sci, Struct Biol Lab, Res Triangle Pk, NC 27709 USA.
[Darden, Thomas] OpenEye Sci Software, Santa Fe, NM 87508 USA.
[Pedersen, Lee G.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA.
RP Pedersen, LG (reprint author), Natl Inst Environm Hlth Sci, Struct Biol Lab, Res Triangle Pk, NC 27709 USA.
EM lee_pedersen@unc.edu
RI perera, Lalith/B-6879-2012; Pedersen, Lee/E-3405-2013
OI perera, Lalith/0000-0003-0823-1631; Pedersen, Lee/0000-0003-1262-9861
FU NIH [HL06350]; NIEHS [Z01 ESO943010-23]; NSF [FRG DMR 0804549]
FX Contract/grant sponsor: Intramural Research Program of the NIH and
NIEHS; contract/grant number: Z01 ESO943010-23; Contract/grant sponsor:
NIH; contract/grant number: HL06350; Contract/grant sponsor: NSF;
contract/grant number: FRG DMR 0804549
NR 74
TC 10
Z9 10
U1 1
U2 19
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0192-8651
J9 J COMPUT CHEM
JI J. Comput. Chem.
PD NOV 30
PY 2010
VL 31
IS 15
BP 2702
EP 2713
DI 10.1002/jcc.21563
PG 12
WC Chemistry, Multidisciplinary
SC Chemistry
GA 656EV
UT WOS:000282309900003
PM 20839297
ER
PT J
AU Taghavy, A
Costanza, J
Pennell, KD
Abriola, LM
AF Taghavy, Arnir
Costanza, Jed
Pennell, Kurt D.
Abriola, Linda M.
TI Effectiveness of nanoscale zero-valent iron for treatment of a PCE-DNAPL
source zone
SO JOURNAL OF CONTAMINANT HYDROLOGY
LA English
DT Article
DE DNAPL; Tetrachloroethene; Source zone treatment; In situ remediation;
Nanoparticles; Zero-valent iron
ID REDUCTIVE DECHLORINATION; GROUNDWATER REMEDIATION; CHLORINATED ETHENES;
MASS-TRANSFER; SAND COLUMNS; HUMIC-ACID; TETRACHLOROETHYLENE;
TRICHLOROETHYLENE; TRANSPORT; NANOPARTICLES
AB Nanoscale zero-valent iron (nZVI) has received considerable attention as a potential in situ remediation technology for treating chlorinated solvent source zones. Experimental and mathematical modeling studies were conducted to investigate the performance of nZVI in the transformation of tetrachloroethene (PCE) entrapped as a dense nonaqueous phase liquid (DNAPL). Injection of a 60 g/L suspension of nZVI into a column containing 20-30 mesh Ottawa sand and PCE-DNAPL at a residual saturation of 5.5% resulted in a uniform distribution of nZVI and minimal displacement of PCE. Subsequent flushing with 267 pore volumes of water containing 3 mM CaCl(2) at a Darcy velocity of 0.75 m/day resulted in steady-state effluent concentrations of PCE near the solubility limit (ca. 200 mg/L) and production of dissolved-phase ethene (10-30 mg/L). Over the duration of the experiment, approximately 30% of the initial PCE-DNAPL mass reacted to form ethene, 50% was eluted as dissolved-phase PCE, and 20% remained in the column as PCE-DNAPL To further explore the implications of the nZVI column results, a multiphase transport model was developed that incorporated rate-limited PCE-DNAPL dissolution and reactions with nZVI. Using a fitted pseudo first-order transformation rate coefficient of 1.42 1/h, the model accurately captured observed trends in effluent concentrations of PCE and ethene and overall mass balance. A model sensitivity study reveals a strong dependence of treatment effectiveness on system characteristics. The sensitivity analysis suggests that an increase in the extent of PCE transformation is facilitated by decreasing flow rate, emplacement of nZVI down-gradient of the DNAPL source zone, and decreasing length of the DNAPL source zone. These findings indicate that, although emplacement of high concentrations of nZVI within a PCE-DNAPL source zone can result in substantial transformation of the parent compound, careful attention to design parameters (e.g. flow rate, location and amount nZVI delivered) will be required to achieve complete conversion to benign reaction products. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Taghavy, Arnir; Pennell, Kurt D.; Abriola, Linda M.] Tufts Univ, Dept Civil & Environm Engn, Medford, MA 02155 USA.
[Costanza, Jed] US EPA, Washington, DC 20036 USA.
RP Abriola, LM (reprint author), Tufts Univ, Dept Civil & Environm Engn, Medford, MA 02155 USA.
EM Linda.Abriola@tufts.edu
RI Pennell, Kurt/F-6862-2010
OI Pennell, Kurt/0000-0002-5788-6397
FU Strategic Environmental Research and Development Program [ER-1487,
W912HQ-06-C-0032]
FX The authors wish to thank Dr. Natalie Capiro for assistance with the
column experiment and Dr. Sushil Kanel for performing supporting column
studies. This research was sponsored by Strategic Environmental Research
and Development Program Project ER-1487 (contract W912HQ-06-C-0032). The
content of this manuscript has not been subject to agency review and
does not necessarily represent the view of the sponsoring agency.
NR 42
TC 24
Z9 24
U1 3
U2 43
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0169-7722
J9 J CONTAM HYDROL
JI J. Contam. Hydrol.
PD NOV 25
PY 2010
VL 118
IS 3-4
SI SI
BP 128
EP 142
DI 10.1016/j.jconhyd.2010.09.001
PG 15
WC Environmental Sciences; Geosciences, Multidisciplinary; Water Resources
SC Environmental Sciences & Ecology; Geology; Water Resources
GA 702LG
UT WOS:000285895600005
PM 20888664
ER
PT J
AU Thomas, R
de la Torre, L
Chang, XQ
Mehrotra, S
AF Thomas, Reuben
de la Torre, Luis
Chang, Xiaoqing
Mehrotra, Sanjay
TI Validation and characterization of DNA microarray gene expression data
distribution and associated moments
SO BMC BIOINFORMATICS
LA English
DT Article
ID CELL-LINES; BLOOD; VARIABILITY; NETWORKS; CANCER; ARRAYS; ERROR; SEX;
INHERITANCE; STATISTICS
AB Background: The data from DNA microarrays are increasingly being used in order to understand effects of different conditions, exposures or diseases on the modulation of the expression of various genes in a biological system. This knowledge is then further used in order to generate molecular mechanistic hypotheses for an organism when it is exposed to different conditions. Several different methods have been proposed to analyze these data under different distributional assumptions on gene expression. However, the empirical validation of these assumptions is lacking.
Results: Best fit hypotheses tests, moment-ratio diagrams and relationships between the different moments of the distribution of the gene expression was used to characterize the observed distributions. The data are obtained from the publicly available gene expression database, Gene Expression Omnibus (GEO) to characterize the empirical distributions of gene expressions obtained under varying experimental situations each of which providing relatively large number of samples for hypothesis testing. All data were obtained from either of two microarray platforms - the commercial Affymetrix mouse 430.2 platform and a non-commercial Rosetta/Merck one. The data from each platform were preprocessed in the same manner.
Conclusions: The null hypotheses for goodness of fit for all considered univariate theoretical probability distributions (including the Normal distribution) are rejected for more than 50% of probe sets on the Affymetrix microarray platform at a 95% confidence level, suggesting that under the tested conditions a priori assumption of any of these distributions across all probe sets is not valid. The pattern of null hypotheses rejection was different for the data from Rosetta/Merck platform with only around 20% of the probe sets failing the logistic distribution goodness-of-fit test. We find that there are statistically significant (at 95% confidence level based on the F-test for the fitted linear model) relationships between the mean and the logarithm of the coefficient of variation of the distributions of the logarithm of gene expressions. An additional novel statistically significant quadratic relationship between the skewness and kurtosis is identified. Data from both microarray platforms fail to identify with any one of the chosen theoretical probability distributions from an analysis of the l-moment ratio diagram.
C1 [de la Torre, Luis; Mehrotra, Sanjay] Northwestern Univ, Dept Ind Engn & Management Sci, Evanston, IL 60208 USA.
[Thomas, Reuben; Chang, Xiaoqing] Natl Inst Environm Hlth Sci, Environm Syst Biol Grp, Mol Toxicol Lab, Res Triangle Pk, NC 27709 USA.
RP Mehrotra, S (reprint author), Northwestern Univ, Dept Ind Engn & Management Sci, Evanston, IL 60208 USA.
EM mehrotra@iems.northwestern.edu
RI Mehrotra, Sanjay/B-7477-2009
FU NIH, National Institute of Environmental Health Sciences
FX This research was supported [in part] by the Intramural Research Program
of the NIH, National Institute of Environmental Health Sciences.
NR 69
TC 7
Z9 7
U1 0
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2105
J9 BMC BIOINFORMATICS
JI BMC Bioinformatics
PD NOV 24
PY 2010
VL 11
AR 576
DI 10.1186/1471-2105-11-576
PG 14
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Mathematical & Computational Biology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Mathematical & Computational Biology
GA 695ON
UT WOS:000285381800001
PM 21092329
ER
PT J
AU Jones-Lepp, TL
Sanchez, CA
Moy, T
Kazemi, R
AF Jones-Lepp, Tammy L.
Sanchez, Charles A.
Moy, Thomas
Kazemi, Reza
TI Method Development and Application To Determine Potential Plant Uptake
of Antibiotics and Other Drugs in Irrigated Crop Production Systems
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE Emerging contaminants; crop uptake; pressurized liquid extraction;
liquid chromatography-electrospray Ion trap-mass spectrometry/mass
spectrometry; LC-MS/MS
ID GRAM-NEGATIVE BACTERIA; WASTE-WATER; VETERINARY ANTIBIOTICS; ILLICIT
DRUGS; RESISTANCE; SOIL; PHARMACEUTICALS; ENVIRONMENTS; MANURE
AB Studies have shown the detection of emerging contaminants (ECs), of which pharmaceuticals are a subset, in surface waters across the United States. The objective of this study was to develop methods, and apply them, to evaluate the potential for food chain transfer when EC-containing waters are used for crop irrigation. Greenhouse experiments were performed in which select food crops were irrigated with water spiked with three antibiotics. Field experiments, at two different sites, were conducted. Select crops were irrigated with wastewater effluent known to contain ECs, EC-free well water, and Colorado River water containing trace-level ECs. The results of the greenhouse studies show the potential for uptake of one or more of the antibiotics evaluated, albeit at very low levels. In those food crops watered with wastewater effluent, only an industrial flavoring agent, N,N'-dimethylphenethylamine (DMPEA), was consistently found. None of the evaluated contaminants were found in crops irrigated with Colorado River water.
C1 [Jones-Lepp, Tammy L.] US EPA, Natl Exposure Res Lab Environm Sci Div, Off Res & Dev, Las Vegas, NV 89119 USA.
[Sanchez, Charles A.] Univ Arizona, Yuma Agr Ctr, Dept Soil Water & Environm Sci, Yuma, AZ 85364 USA.
[Moy, Thomas] US EPA, Senior Environm Employee Program, Las Vegas, NV 89119 USA.
[Kazemi, Reza] US EPA, Student Serv Contract, Las Vegas, NV 89119 USA.
RP Jones-Lepp, TL (reprint author), US EPA, Natl Exposure Res Lab Environm Sci Div, Off Res & Dev, Las Vegas, NV 89119 USA.
EM jones-lepp.tammy@epa.gov
FU U.S. Environmental Protection Agency through its Office of Research and
Development
FX The U.S. Environmental Protection Agency through its Office of Research
and Development funded and managed the research described here. It has
been subjected to the Agency's administrative review and approved for
publication. Mention of trade names or commercial products does not
constitute endorsement or recommendation for use.
NR 29
TC 42
Z9 42
U1 5
U2 58
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD NOV 24
PY 2010
VL 58
IS 22
BP 11568
EP 11573
DI 10.1021/jf1028152
PG 6
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
Technology
SC Agriculture; Chemistry; Food Science & Technology
GA 680AR
UT WOS:000284203000007
PM 20964347
ER
PT J
AU Brook, RD
Shin, HH
Bard, RL
Burnett, RT
Vette, A
Croghan, C
Thornburg, J
Rodes, C
Williams, R
AF Brook, Robert D.
Shin, Hwashin H.
Bard, Robert L.
Burnett, Richard T.
Vette, Alan
Croghan, Carry
Thornburg, Jonathan
Rodes, Charles
Williams, Ron
TI Rapid Effects of Personal-Level Ambient Fine Particulate Matter Exposure
on Arterial Hemodynamics and Vascular Function during the Same Day
SO CIRCULATION
LA English
DT Meeting Abstract
DE Air pollution; Endothelial function; Smoking
C1 Univ Michigan, Ann Arbor, MI 48109 USA.
Hlth Canada, Ottawa, MI USA.
Hlth Canada, Ottawa, ON K1A 0L2, Canada.
US EPA, Rsch Triangle Pk, NC USA.
RTI Int, Rsch Triangle Pk, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD NOV 23
PY 2010
VL 122
IS 21
SU S
MA A9390
PG 2
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA V21UD
UT WOS:000208231600399
ER
PT J
AU Gowdy, KM
Krantz, QT
King, C
Boykin, E
Jaspers, I
Linak, WP
Gilmour, MI
AF Gowdy, Kymberly M.
Krantz, Quentin T.
King, Charly
Boykin, Elizabeth
Jaspers, Ilona
Linak, William P.
Gilmour, M. Ian
TI Role of oxidative stress on diesel-enhanced influenza infection in mice
SO PARTICLE AND FIBRE TOXICOLOGY
LA English
DT Article
ID RESPIRATORY SYNCYTIAL VIRUS; EXHAUST PARTICLE CHEMICALS; AMBIENT
PARTICULATE MATTER; AIRWAY EPITHELIAL-CELLS; INFLAMMATORY RESPONSES;
UNITED-STATES; LISTERIA-MONOCYTOGENES; ENGINE EMISSIONS; IL-4
PRODUCTION; TERM EXPOSURE
AB Numerous studies have shown that air pollutants, including diesel exhaust (DE), reduce host defenses, resulting in decreased resistance to respiratory infections. This study sought to determine if DE exposure could affect the severity of an ongoing influenza infection in mice, and examine if this could be modulated with antioxidants. BALB/c mice were treated by oropharyngeal aspiration with 50 plaque forming units of influenza A/HongKong/8/68 and immediately exposed to air or 0.5 mg/m(3) DE (4 hrs/day, 14 days). Mice were necropsied on days 1, 4, 8 and 14 post-infection and lungs were assessed for virus titers, lung inflammation, immune cytokine expression and pulmonary responsiveness (PR) to inhaled methacholine. Exposure to DE during the course of infection caused an increase in viral titers at days 4 and 8 post-infection, which was associated with increased neutrophils and protein in the BAL, and an early increase in PR. Increased virus load was not caused by decreased interferon levels, since IFN-beta levels were enhanced in these mice. Expression and production of IL-4 was significantly increased on day 1 and 4 p.i. while expression of the Th1 cytokines, IFN-gamma and IL-12p40 was decreased. Treatment with the antioxidant N-acetylcysteine did not affect diesel-enhanced virus titers but blocked the DE-induced changes in cytokine profiles and lung inflammation. We conclude that exposure to DE during an influenza infection polarizes the local immune responses to an IL-4 dominated profile in association with increased viral disease, and some aspects of this effect can be reversed with antioxidants.
C1 [Krantz, Quentin T.; King, Charly; Boykin, Elizabeth; Gilmour, M. Ian] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Gowdy, Kymberly M.] Duke Univ, Med Ctr, Div Pulm Allergy & Crit Care, Durham, NC 27710 USA.
[Linak, William P.] US EPA, Air Pollut Prevent & Control Div, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
[Jaspers, Ilona] Univ N Carolina, Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC 27599 USA.
[Jaspers, Ilona] Univ N Carolina, Dept Pediat, Chapel Hill, NC 27599 USA.
RP Gilmour, MI (reprint author), US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM gilmour.ian@epa.gov
FU EPA-NC [CT829470]
FX We thank Mary Daniels, Debora Andrews, Judy Richards, Daniel Janek,
Gaynelle McGee, James Lehman, Dr. Seung Hyun Cho, and Dr. Weiyan Zhu for
technical assistance and Dr. Mac Law for pathology grading, Drs. Robert
Luebke, and Mary Jane Selgrade, for their review of this manuscript. The
project was supported by grant from the EPA-NC State Cooperative
agreement (# CT829470) (K.G.). This paper has been reviewed by the
National Health and Environmental Effects Research Laboratory, US
Environmental Protection Agency, and approved for publication. Approval
does not signify that the contents necessarily reflect the views and
policies of the Agency, nor does the mention of trade names or
commercial products constitute endorsement or recommendation for use.
NR 73
TC 10
Z9 10
U1 0
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-8977
J9 PART FIBRE TOXICOL
JI Part. Fibre Toxicol.
PD NOV 22
PY 2010
VL 7
AR 34
DI 10.1186/1743-8977-7-34
PG 15
WC Toxicology
SC Toxicology
GA 693GA
UT WOS:000285211400001
PM 21092162
ER
PT J
AU Lardinois, OM
Chatterjee, S
Mason, RP
Tomer, KB
Deterding, LJ
AF Lardinois, Olivier M.
Chatterjee, Saurabh
Mason, Ronald P.
Tomer, Kenneth B.
Deterding, Leesa J.
TI Biotinylated Analogue of the Spin-Trap 5,5-Dimethyl-1-pyrroline-N-oxide
for the Detection of Low-Abundance Protein Radicals by Mass Spectrometry
SO ANALYTICAL CHEMISTRY
LA English
DT Letter
ID CYTOCHROME-C PEROXIDASE; IDENTIFICATION; DERIVATIVES; SITE; EPR
AB Protein radicals are implicated in oxidative stress and are associated with a wide range of diseases and disorders. In the present work, we describe the specific application of a newly synthesized nitrone spin trap, Bio-SS-DMPO, for the detection of these highly reactive species by mass spectrometry (MS). Bio-SS-DMPO is a biotinylated analogue of the spin-trap 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) that allows for specific capture of the protein(s)/peptide(s) labeled by the spin-trap on a (strept)avidin-bound solid matrix. The disulfide bond in the linker arm joining biotin to DMPO can be cleaved to release captured spin-adduct peptide from the solid matrix. This (strept)avidin-based affinity purification reduces the complexity of the samples prior to MS analyses, thereby facilitating the location of the sites of spin trap addition. In addition, the biotin moiety on the spin-trap can efficiently be probed with (strept)avidin-conjugated reporter. This offers an effective means to visualize the presence of DMPO-adducted proteins in intact cells.
C1 [Tomer, Kenneth B.; Deterding, Leesa J.] Natl Inst Environm Hlth Sci, Struct Biol Lab, NIH, DHHS, Res Triangle Pk, NC 27709 USA.
[Lardinois, Olivier M.; Chatterjee, Saurabh; Mason, Ronald P.] Natl Inst Environm Hlth Sci, Lab Toxicol & Pharmacol, NIH, DHHS, Res Triangle Pk, NC 27709 USA.
RP Deterding, LJ (reprint author), Natl Inst Environm Hlth Sci, Struct Biol Lab, NIH, DHHS, POB 12233,MD F0-03, Res Triangle Pk, NC 27709 USA.
EM deterdi2@niehs.nih.gov
RI Tomer, Kenneth/E-8018-2013
FU Intramural NIH HHS [Z01 ES050139-14, ZIA ES050150-14, Z99 ES999999];
NIEHS NIH HHS [Z01 ES050171, Z01 ES050139]
NR 15
TC 2
Z9 2
U1 0
U2 10
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0003-2700
J9 ANAL CHEM
JI Anal. Chem.
PD NOV 15
PY 2010
VL 82
IS 22
BP 9155
EP 9158
DI 10.1021/ac1023183
PG 4
WC Chemistry, Analytical
SC Chemistry
GA 678MQ
UT WOS:000284080500006
PM 20957988
ER
PT J
AU Koutros, S
Freeman, LEB
Berndt, SI
Andreotti, G
Lubin, JH
Sandler, DP
Hoppin, JA
Yu, K
Li, QZ
Burdette, LA
Yuenger, J
Yeager, M
Alavanja, MCR
AF Koutros, Stella
Freeman, Laura E. Beane
Berndt, Sonja I.
Andreotti, Gabriella
Lubin, Jay H.
Sandler, Dale P.
Hoppin, Jane A.
Yu, Kai
Li, Qizhai
Burdette, Laura A.
Yuenger, Jeffrey
Yeager, Meredith
Alavanja, Michael C. R.
TI Pesticide Use Modifies the Association Between Genetic Variants on
Chromosome 8q24 and Prostate Cancer
SO CANCER RESEARCH
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; SINGLE-NUCLEOTIDE POLYMORPHISMS; AGRICULTURAL
HEALTH; DNA-DAMAGE; RISK LOCUS; IN-VITRO; COLORECTAL-CANCER; MYC
EXPRESSION; MULTIPLE LOCI; SUSCEPTIBILITY
AB Genome-wide association studies have identified 8q24 region variants as risk factors for prostate cancer. In the Agricultural Health Study, a prospective study of licensed pesticide applicators, we observed increased prostate cancer risk with specific pesticide use among those with a family history of prostate cancer. Thus, we evaluated the interaction among pesticide use, 8q24 variants, and prostate cancer risk. The authors estimated odds ratios (OR) and 95% confidence intervals (95% CI) for interactions among 211 8q24 variants, 49 pesticides, and prostate cancer risk in 776 cases and 1,444 controls. The ORs for a previously identified variant, rs4242382, and prostate cancer increased significantly (P < 0.05) with exposure to the organophosphate insecticide fonofos, after correction for multiple testing, with per allele ORnonexposed of 1.17 (95% CI, 0.93-1.48), per allele ORlow of 1.30 (95% CI, 0.75-2.27), and per allele ORhigh of 4.46 (95% CI, 2.17-9.17; P-interaction = 0.002, adjusted P-interaction = 0.02). A similar effect modification was observed for three other organophosphate insecticides (coumaphos, terbufos, and phorate) and one pyrethroid insecticide (permethrin). Among ever users of fonofos, subjects with three or four risk alleles at rs7837328 and rs4242382 had approximately three times the risk of prostate cancer (OR, 3.14; 95% CI, 1.41-7.00) compared with subjects who had zero risk alleles and never used fonofos. We observed a significant interaction among variants on chromosome 8q24, pesticide use, and risk of prostate cancer. Insecticides, particularly organophosphates, were the strongest modifiers of risk, although the biological mechanism is unclear. This is the first report of effect modification between 8q24 and an environmental exposure on prostate cancer risk. Cancer Res; 70(22); 9224-33. (C) 2010 AACR.
C1 [Koutros, Stella] NCI, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Rockville, MD 20852 USA.
[Sandler, Dale P.; Hoppin, Jane A.] Natl Inst Environm Hlth Sci, Epidemiol Branch, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC USA.
[Li, Qizhai] Chinese Acad Sci, Acad Math & Syst Sci, Key Lab Syst & Control, Beijing, Peoples R China.
[Burdette, Laura A.; Yuenger, Jeffrey; Yeager, Meredith] NCI, Core Genotyping Facil, Adv Technol Program, Frederick, MD 21701 USA.
RP Koutros, S (reprint author), NCI, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, 6120 Execut Blvd,EPS 8115,MSC 7240, Rockville, MD 20852 USA.
EM KoutrosS@mail.nih.gov
RI Beane Freeman, Laura/C-4468-2015;
OI Beane Freeman, Laura/0000-0003-1294-4124; Sandler,
Dale/0000-0002-6776-0018
FU NIH, National Cancer Institute, Division of Cancer Epidemiology and
Genetics [Z01CP010119]; National Institute of Environmental Health
Sciences [Z01ES049030]
FX Intramural Research Program of the NIH, National Cancer Institute,
Division of Cancer Epidemiology and Genetics (Z01CP010119) and National
Institute of Environmental Health Sciences (Z01ES049030). We thank the
participants in the Agricultural Health Study for their contributions in
support of this research.
NR 49
TC 24
Z9 25
U1 0
U2 3
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
J9 CANCER RES
JI Cancer Res.
PD NOV 15
PY 2010
VL 70
IS 22
BP 9224
EP 9233
DI 10.1158/0008-5472.CAN-10-1078
PG 10
WC Oncology
SC Oncology
GA 680DT
UT WOS:000284213300028
PM 20978189
ER
PT J
AU Washington, JW
Yoo, H
Ellington, JJ
Jenkins, TM
Libelo, EL
AF Washington, John W.
Yoo, Hoon
Ellington, J. Jackson
Jenkins, Thomas M.
Libelo, E. Laurence
TI Concentrations, Distribution, and Persistence of Perfluoroalkylates in
Sludge-Applied Soils near Decatur, Alabama, USA
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID FLUOROTELOMER ALCOHOLS; WATER; CHROMATOGRAPHY; OPTIMIZATION; EXTRACTION
AB Sludges generated at a wastewater treatment plant (WWTP) in Decatur, Alabama have been applied to agricultural fields for more than a decade. Waste-stream sources to this WWTP during this period included industries that work with fluorotelomer compounds, and sludges from this facility have been found to be elevated in perfluoroalkylates (PFAs). With this knowledge, the U.S. Environmental Protection Agency collected soil samples from sludge-applied fields as well as nearby "background" fields for PFA analysis. Samples from the sludge-applied fields had PFAs at much higher concentrations than in the background fields; generally the highest concentrations were perfluorodecanoic acid (<= 990 ng/g), perfluorododecanoic acid (<= 530 ng/g), perfluorooctanoic acid (<= 320 ng/g), and perfluorooctane sulfonate (<= 410 ng/g). Contrasts in PFA concentration between surface and deeper soil samples tended to be more pronounced in long-chain congeners than shorter chains, perhaps reflecting relatively lower environmental mobilities for longer chains. Several PFAs were correlated with secondary fluorotelomer alcohols (sec-FTOHs) suggesting that PFAs are being formed by degradation of sec-FTOHs. Calculated PFA disappearance half-lives for C6 through C11 alkylates ranged from about 1 to 3 years and increase with increasing chain-length, again perhaps reflecting lower mobility of the longer-chained compounds.
C1 [Washington, John W.; Yoo, Hoon; Ellington, J. Jackson; Jenkins, Thomas M.] US EPA, Ecosyst Res Div, Natl Exposure Res Lab, Off Res & Dev, Athens, GA 30605 USA.
[Yoo, Hoon] CNR, Washington, DC 20460 USA.
[Jenkins, Thomas M.] SSA, Washington, DC 20460 USA.
[Libelo, E. Laurence] US EPA, Off Pollut Prevent & Tox, Washington, DC 20460 USA.
RP Washington, JW (reprint author), US EPA, Ecosyst Res Div, Natl Exposure Res Lab, Off Res & Dev, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM Washington.john@epa.gov
FU The United States Environmental Protection Agency (USEPA), through its
Office of Research and Development; The USEPA Office of Pollution
Prevention and Toxics
FX The United States Environmental Protection Agency (USEPA), through its
Office of Research and Development, managed and partially funded the
work described here. The USEPA Office of Pollution Prevention and Toxics
shared in funding of this work as well. The work has been subjected to
the Agency's administrative review and approved for publication. We
thank Cathy Fehrenbacher and Gail Mitchell for their efforts and support
of this work. We thank Laurence Libelo, Andy Lindstrom, Tim Collette,
Jack Jones, Eric Weber, and anonymous reviewers for helpful reviews.
NR 16
TC 42
Z9 45
U1 5
U2 34
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD NOV 15
PY 2010
VL 44
IS 22
BP 8390
EP 8396
DI 10.1021/es1003846
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 680QA
UT WOS:000284248300007
PM 20949951
ER
PT J
AU Yoo, H
Washington, JW
Ellington, JJ
Jenkins, TM
Neill, MP
AF Yoo, Hoon
Washington, John W.
Ellington, J. Jackson
Jenkins, Thomas M.
Neill, Michael P.
TI Concentrations, Distribution, and Persistence of Fluorotelomer Alcohols
in Sludge-Applied Soils near Decatur, Alabama, USA
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID POLYFLUORINATED ALKYL SUBSTANCES; TREATMENT-PLANT; ACIDS;
CHROMATOGRAPHY; PRODUCTS; URBAN; WATER
AB Soil samples were collected for fluorotelomer alcohol (FTOH) analyses from six fields to which sludge had been applied and one "background" field that had not received sludge. Ten analytes in soil extracts were quantified using GC/MS. Sludge-applied fields had surface soil FTOH concentrations exceeding levels found in the background field. For 8:2nFTOH, which can degrade to perfluorooctanoic acid, impacted surface-soils ranged from 5 to 73 ng/g dry weight clearly exceeding the background field in which 8:2nFTOH was not detected. The highest [FTOH] generally was 10:2nFTOH, which had concentrations of <5.6 to 166 ng/g. For the first time, we document the persistence of straight-chained primary FTOHs (n-FTOHs) and branch-chained secondary FTOHs (sec-FTOHs), which are transformation products of n-FTOHs, in field soils for at least five years after sludge application. Ratios of sec-FTOHs to n-FTOHs were highest for 7:2sFTOH/8:2nFTOH (similar to 50%) and decreased with increasing chain length to a minimum for the longest-chained analytes, 13:2sFTOH/14:2nFTOH (similar to 10%). Disappearance half-lives for FTOHs, calculated with these data, ranged from 0.85 to 1.8 years. These analytical results show that the practice of sludge application to land is a pathway for the introduction of FTOHs and, accordingly, their transformation products, perfluorocarboxylic acids, into the environment
C1 [Yoo, Hoon; Washington, John W.; Jenkins, Thomas M.] US EPA, Ecosyst Res Div, Natl Exposure Res Lab, Off Res & Dev, Athens, GA 30605 USA.
[Yoo, Hoon; Ellington, J. Jackson] CNR, Athens, GA 30605 USA.
[Jenkins, Thomas M.] Senior Serv Amer, Athens, GA 30605 USA.
RP Washington, JW (reprint author), US EPA, Ecosyst Res Div, Natl Exposure Res Lab, Off Res & Dev, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM Washington.john@epa.gov
FU The United States Environmental Protection Agency (USEPA), through its
Office of Research and Development; The USEPA Office of Pollution
Prevention and Toxics
FX The United States Environmental Protection Agency (USEPA), through its
Office of Research and Development, managed and partially funded the
work described here. The USEPA Office of Pollution Prevention and Toxics
shared in funding of this work as well. The work has been subjected to
the Agency's administrative review and approved for publication. We
thank Cathy Fehrenbacher and Gail Mitchell for their efforts and support
of this work. We thank Tim Collette, Jack Jones, and Eric Weber for
helpful reviews.
NR 29
TC 37
Z9 40
U1 5
U2 38
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD NOV 15
PY 2010
VL 44
IS 22
BP 8397
EP 8402
DI 10.1021/es100390r
PG 6
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 680QA
UT WOS:000284248300008
PM 20949952
ER
PT J
AU Smith, EM
Plewa, MJ
Lindell, CL
Richardson, SD
Mitch, WA
AF Smith, Emma Marie
Plewa, Michael J.
Lindell, Crystal L.
Richardson, Susan D.
Mitch, William A.
TI Comparison of Byproduct Formation in Waters Treated with Chlorine and
Iodine: Relevance to Point-of-Use Treatment
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID DRINKING-WATER; DISINFECTION; CHLORAMINATION; NITROSAMINE; PRECURSORS;
OXIDATION; TOXICITY; NDMA
AB Due to their efficacy in deactivating a range of microbial pathogens, particularly amoebic cysts, iodine-based disinfectants have been a popular option for point-of-use (POU) drinking water disinfection by campers, the military, and rural consumers in developing countries. Recently, concerns regarding the formation of cytotoxic and genotoxic iodinated disinfection byproducts (I-DBPs) have arisen during chloramine disinfection of iodide-containing waters in the developed world; similar concerns should pertain to iodine-based POU disinfection. Because there are alternative POU disinfection techniques, including chlorine-based disinfectants, this paper compared disinfection byproduct formation from a range of iodine-based disinfectants at their recommended dosages to chlorination and chloramination under overdosing conditions. Just as chloroform was the predominant trihalomethane (THM) forme during chlorination or chloramination, iodoform was the predominant THM formed during iodination. Conditions fostering THM formation were similar between these treatments, except that THM formation during chlorination increased with pH, while it was slightly elevated at circumneutral pH during iodination. lodoform formation during treatment with iodine tincture was higher than during treatment with iodine tablets. On a molar basis, iodoform formation during treatment with iodine tincture was 20-60% of the formation of chloroform during chlorination, and total organic iodine (101) formation was twice that of total organic chlorine (TOCl), despite the 6-fold higher oxidant dose during chlorination. Based upon previous measurements of chronic mammalian cell cytotoxicity for the individual THMs, consumers of two waters treated with iodine tincture would receive the same THM-associated cytotoxic exposure in 4-19 days as a consumer of the same waters treated with a 6-fold higher dose of chlorine over 1 year. Iodoacetic acid, diiodoacetic acid, and other iodo-acids were also formed with iodine tincture treatment, but at levels <11% of iodoform. However, testing of a Lifestraw Personal POU device, which combines an iodinated anion exchange resin with activated carbon post-treatment, indicated minimal formation of I-DBPs and no iodine residual. Although N-nitrosamines have been associated with oxidant contact with anion exchange resins, N-nitrosamine formation rapidly declined to low levels (4 ng/L) using the Lifestraw device after the first few flushes of water.
C1 [Smith, Emma Marie; Mitch, William A.] Yale Univ, Dept Chem & Environm Engn, New Haven, CT 06520 USA.
[Plewa, Michael J.] Univ Illinois, Ctr Adv Mat Purificat Water Syst, Urbana, IL 61801 USA.
[Plewa, Michael J.] Univ Illinois, Dept Crop Sci, Urbana, IL 61801 USA.
[Lindell, Crystal L.; Richardson, Susan D.] US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA.
RP Mitch, WA (reprint author), Yale Univ, Dept Chem & Environm Engn, New Haven, CT 06520 USA.
EM william.mitch@yale.edu
FU National Science Foundation [CBET-0651732]
FX This research was partially supported by a grant from the National
Science Foundation (CBET-0651732). We would like to thank Xiangru Zhang
and Dave Ho of the Hong Kong University of Science & Technology and Mark
Manahan from Cosa Instruments for helpful advice with the TOX
measurements. This paper has been reviewed in accordance with the U.S.
Environmental Protection Agency's peer and administrative review
policies and approved for publication. Mention of trade names or
commercial products does not constitute endorsement or recommendation
for use by the U.S. EPA.
NR 27
TC 36
Z9 37
U1 10
U2 94
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD NOV 15
PY 2010
VL 44
IS 22
BP 8446
EP 8452
DI 10.1021/es102746u
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 680QA
UT WOS:000284248300016
PM 20964286
ER
PT J
AU Carlton, AG
Bhave, PV
Napelenok, SL
Edney, ED
Sarwar, G
Pinder, RW
Pouliot, GA
Houyoux, M
AF Carlton, Annmarie G.
Bhave, Prakash V.
Napelenok, Sergey L.
Edney, Edward D.
Sarwar, Golam
Pinder, Robert W.
Pouliot, George A.
Houyoux, Marc
TI Model Representation of Secondary Organic Aerosol in CMAQv4.7
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID UNITED-STATES; SESQUITERPENE EMISSIONS; AROMATIC-HYDROCARBONS; AIR;
PHOTOOXIDATION; IMPACT; PERFORMANCE; OXIDATION; MIXTURES; ISOPRENE
AB Numerous scientific upgrades to the representation of secondary organic aerosol (SOA) are incorporated into the Community Multiscale Air Quality (CMAQ) modeling system. Additions include several recently identified SOA precursors: benzene, isoprene, and sesquiterpenes; and pathways: in-cloud oxidation of glyoxal and methylglyoxal, particle-phase oligomerization, and acid enhancement of isoprene SOA. NOx-dependent aromatic SOA yields are also added along with new empirical measurements of the enthalpies of vaporization and organic mass-to-carbon ratios. For the first time, these SOA precursors, pathways and empirical parameters are included simultaneously in an air quality model for an annual simulation spanning the continental U.S. Comparisons of CMAQ-modeled secondary organic carbon (OCsec) with semiempirical estimates screened from 165 routine monitoring sites across the U.S. indicate the new SOA module substantially improves model performance. The most notable improvement occurs in the central and southeastern U.S. where the regionally averaged temporal correlations (r) between modeled and semiempirical OCsec increase from -0.5 to 0.8 and -0.3 to 0.8, respectively, when the new SOA module is employed. Wintertime OCsec results improve in all regions of the continental U.S. and the seasonal and regional patterns of biogenic SOA are better represented.
C1 [Carlton, Annmarie G.; Bhave, Prakash V.; Napelenok, Sergey L.; Edney, Edward D.; Sarwar, Golam; Pinder, Robert W.; Pouliot, George A.; Houyoux, Marc] US EPA, Res Triangle Pk, NC 27711 USA.
RP Carlton, AG (reprint author), Dept Environm Sci, 14 Coll Farm Rd, New Brunswick, NJ 08903 USA.
EM carlton@envsci.rutgers.edu; bhave.prakash@epa.gov
RI Carlton, Annmarie/A-7867-2011; Pinder, Robert/F-8252-2011; Bhave,
Prakash/L-1958-2013; Napelenok, Sergey/I-7986-2014;
OI Carlton, Annmarie/0000-0002-8574-1507; Pinder,
Robert/0000-0001-6390-7126; Bhave, Prakash/0000-0002-2573-951X;
Napelenok, Sergey/0000-0002-7038-7445; Pouliot,
George/0000-0003-3406-4814
FU United States Environmental Protection Agency through its Office of
Research and Development
FX This work is the result of a large collaboration across the EPA
involving a variety of groups, namely AMAD, HEASD, NRMRL, OAQPS, OTAQ,
and NCER. We acknowledge helpful contributions from Tad Kleindienst,
Chris Geron, Kristen Foley, Heather Simon, Nancy Hwang, Charles Chang,
Lucille Bender, and Ruen Tang. We acknowledge Rob Griffin for verifying
data and methods used in his 1999 JGR article and Rohit Mathur and Bill
Benjey for administrative support. Bonyoung Koo, Greg Yarwood, Ralph
Morris provided helpful discussions during the development of the new
SOA module. Disclaimer: The United States Environmental Protection
Agency through its Office of Research and Development funded and managed
the research described here. It has been subjected to Agency's
administrative review and approved for publication.
NR 67
TC 159
Z9 164
U1 13
U2 134
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD NOV 15
PY 2010
VL 44
IS 22
BP 8553
EP 8560
DI 10.1021/es100636q
PG 8
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 680QA
UT WOS:000284248300033
PM 20883028
ER
PT J
AU Macpherson, AJ
Schulze, MD
Carter, DR
Vidal, E
AF Macpherson, Alexander J.
Schulze, Mark D.
Carter, Douglas R.
Vidal, Edson
TI A Model for comparing reduced impact logging with conventional logging
for an Eastern Amazonian Forest
SO FOREST ECOLOGY AND MANAGEMENT
LA English
DT Article
DE Brazilian Amazon; Model; Harvest
ID SWIETENIA MACROPHYLLA KING; BRAZILIAN-AMAZON; TIMBER PRODUCTION;
TROPICAL FORESTS; GROWTH-MODEL; RAIN-FOREST; MANAGEMENT; YIELD;
SUSTAINABILITY; DYNAMICS
AB Using data from a logging experiment in the eastern Brazilian Amazon region, we develop a matrix growth and yield model that captures the dynamic effects of harvest system choice on forest structure and composition. Multinomial logistic regression is used to estimate the growth transition parameters for a 10-year time step, while a Poisson regression model is used to estimate recruitment parameters. The model is designed to be easily integrated with an economic model of decisionmaking to perform tropical forest policy analysis. The model is used to compare the long-run structure and composition of a stand arising from the choice of implementing either conventional logging techniques or more carefully planned and executed reduced-impact logging (RIL) techniques, contrasted against a baseline projection of an unlogged forest. Results from "log and leave" scenarios show that a stand logged according to Brazilian management requirements will require well over 120 years to recover its initial commercial volume, regardless of logging technique employed. Implementing RIL, however, accelerates this recovery. Scenarios imposing a 40-year cutting cycle raise the possibility of sustainable harvest volumes, although at significantly lower levels than is implied by current regulations. Meeting current Brazilian forest policy goals may require an increase in the planned total area of permanent production forest or the widespread adoption of silvicultural practices that increase stand recovery and volume accumulation rates after RIL harvests. Published by Elsevier B.V.
C1 [Macpherson, Alexander J.; Carter, Douglas R.; Vidal, Edson] Univ Florida, Sch Forest Resources & Conservat, Gainesville, FL 32611 USA.
[Macpherson, Alexander J.; Vidal, Edson] Univ Sao Paulo, ESALQ, BR-13418900 Sao Paulo, Brazil.
[Macpherson, Alexander J.; Vidal, Edson] Oregon State Univ, Dept Forest Ecosyst & Soc, Corvallis, OR 97331 USA.
[Schulze, Mark D.] Inst Homem & Meio Ambiente Amazonia IMAZON, BR-66060160 Belem, Para, Brazil.
RP Macpherson, AJ (reprint author), US EPA, Off Air & Radiat, 109 TW Alexander Dr,E439-02, Res Triangle Pk, NC 27711 USA.
EM macpherson.alex@epa.gov; mark.schulze@oregonstate.edu; drcart@ufl.edu;
edvida@esalq.usp.br
RI Vidal, Edson/D-4279-2012; Schulze, Mark/H-4921-2013
OI Vidal, Edson/0000-0002-8028-6998;
FU United States General Administration Office through the Latin America
and Caribbean Department of the United States Agency for International
Development [512-A-00-03-00026-00]; University of Florida through a
National Science Foundation [DGE-0221599]; Milton and Miriam Handler
Foundation; Conselho Nacional de Desenvolvimento Cientifico e
Tecnologico (CNPq) [481097/2008-2]
FX This publication was possible due to support from the United States
General Administration Office through the Latin America and Caribbean
Department of the United States Agency for International Development
under the terms of the International Cooperation Agreement no.
512-A-00-03-00026-00. Additional funding was provided by the Working
Forests in the Tropics Program at the University of Florida through a
National Science Foundation Integrated Graduate Education and Research
Traineeship grant (DGE-0221599), by the Milton and Miriam Handler
Foundation, and by the Conselho Nacional de Desenvolvimento Cientifico e
Tecnologico (CNPq Process no. 481097/2008-2). We thank Christina
Staudhammer and two anonymous reviewers for reviewing this article. This
project received logistic support from the Fazenda Agrosete owners, Mr.
Persio Lima and Mr. Thales Lima. This work would not have been possible
without the help of many people in the field. We especially thank Frank
Pantoja, Damiao Farias, Manuel Farias, Miguel Lopes, Marcelo Galdino de
Almeida, Eliana Farias, Manuel Vitorino, Miguel Alves, Joseildo Pantoja,
and Waldemir Ribeiro da Cruz.
NR 43
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Z9 11
U1 1
U2 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-1127
J9 FOREST ECOL MANAG
JI For. Ecol. Manage.
PD NOV 15
PY 2010
VL 260
IS 11
BP 2002
EP 2011
DI 10.1016/j.foreco.2010.08.050
PG 10
WC Forestry
SC Forestry
GA 682ID
UT WOS:000284393700009
ER
PT J
AU Vane, LM
Namboodiri, VV
Meier, RG
AF Vane, Leland M.
Namboodiri, Vasudevan V.
Meier, Richard G.
TI Factors affecting alcohol-water pervaporation performance of hydrophobic
zeolite-silicone rubber mixed matrix membranes
SO JOURNAL OF MEMBRANE SCIENCE
LA English
DT Article
DE Fermentation broth; Pervaporation; Mixed matrix Membranes; Ethanol;
Butanol
ID HIGHLY CONCENTRATED BIOETHANOL; COATED SILICALITE MEMBRANES; DILUTE
AQUEOUS-SOLUTIONS; FILLED PDMS MEMBRANES; FERMENTATION BROTHS; COMPOSITE
MEMBRANES; ETHANOL-PRODUCTION; ABE FERMENTATION; SILANOL GROUPS;
ACETIC-ACID
AB Mixed matrix membranes (MMMs) consisting of ZSM-5 zeolite particles dispersed in silicone rubber exhibited ethanol-water pervaporation permselectivities up to five times that of silicone rubber alone and three times higher than simple vapor-liquid equilibrium (VLE). A number of conditions resulted in the deterioration in pervaporation performance of these MMMs. Long-term exposure to simple binary ethanol-water mixtures resulted in slow declines in ethanol permeability, water permeability, and selectivity. Treating the particles by quenching them in linear short-chain alcohols immediately after calcination protected the MMM against this performance decline. In addition, rapid and dramatic reductions in both ethanol permeability and selectivity occurred when the MMMs were exposed to a centrifuged yeast fermentation broth. Exposure to a clarified acetone/n-butanol/ethanol (ABE) fermentation broth also resulted in marked reductions in performance, albeit less severe and not as rapid as with the yeast broth. The effect of the broths was not easily reversed. The most effective regeneration scheme was soaking the MMM in 100% n-butanol, which fully recovered the original performance. Zeolite pore blockage due to adsorption of minor constituents in the broths, including organic acids, esters, alcohols, and esterification reaction products was identified as the likely cause of performance changes. Published by Elsevier B.V.
C1 [Vane, Leland M.; Namboodiri, Vasudevan V.; Meier, Richard G.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Vane, LM (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
EM Vane.Leland@epa.gov
FU USEPA
FX The authors wish to thank Dr. Shekar Govindaswamy (Lakeshore
Engineering) for preparing the S. cerevisiae fermentation broth sampies,
Franklin Alvarez (USEPA) for carrying out a portion of the pervaporation
experiments, Dr. Yonggui Shan (Pegasus Technical Services) for GC-MS
analyses, and Dr. Nasib Qureshi (USDA) for supplying the ABE broth and
for general discussions regarding this topic. Any mention of trade names
or commercial products does not constitute an endorsement or
recommendation for use. R. Meier received support through the USEPA's
Senior Environmental Employee program as administered by the National
Council on Aging.
NR 52
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U1 5
U2 64
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0376-7388
J9 J MEMBRANE SCI
JI J. Membr. Sci.
PD NOV 15
PY 2010
VL 364
IS 1-2
BP 102
EP 110
DI 10.1016/j.memsci.2010.08.006
PG 9
WC Engineering, Chemical; Polymer Science
SC Engineering; Polymer Science
GA 677EO
UT WOS:000283972100012
ER
PT J
AU He, F
Shaffer, ML
Rodriguez-Colon, S
Bixler, EO
Vgontzas, AN
Williams, RW
Wu, RL
Cascio, WE
Liao, DP
AF He, Fan
Shaffer, Michele L.
Rodriguez-Colon, Sol
Bixler, Edward O.
Vgontzas, Alexandros N.
Williams, Ronald W.
Wu, Rongling
Cascio, Wayne E.
Liao, Duanping
TI Acute effects of fine particulate air pollution on ST segment height: A
longitudinal study
SO ENVIRONMENTAL HEALTH
LA English
DT Article
ID HEART-RATE-VARIABILITY; CONCENTRATED AMBIENT PARTICLES; CARDIAC
AUTONOMIC CONTROL; MYOCARDIAL-ISCHEMIA; CARDIOVERTER-DEFIBRILLATORS;
DISEASE PATIENTS; DISTRIBUTED LAG; APOE(-/-) MICE; ASSOCIATION;
REPOLARIZATION
AB Background: The mechanisms for the relationship between particulate air pollution and cardiac disease are not fully understood. Air pollution-induced myocardial ischemia is one of the potentially important mechanisms.
Methods: We investigate the acute effects and the time course of fine particulate pollution (PM2.5) on myocardium ischemic injury as assessed by ST-segment height in a community-based sample of 106 healthy non-smokers. Twenty-four hour beat-to-beat electrocardiogram (ECG) data were obtained using a high resolution 12-lead Holter ECG system. After visually identifying and removing all the artifacts and arrhythmic beats, we calculated beat-to-beat ST-height from ten leads (inferior leads II, III, and aVF; anterior leads V3 and V4; septal leads V1 and V2; lateral leads I, V5, and V6,). Individual-level 24-hour real-time PM2.5 concentration was obtained by a continuous personal PM2.5 monitor. We then calculated, on a 30-minute basis, the corresponding time-of-the-day specific average exposure to PM2.5 for each participant. Distributed lag models under a linear mixed-effects models framework were used to assess the regression coefficients between 30-minute PM2.5 and ST-height measures from each lead; i.e., one lag indicates a 30-minute separation between the exposure and outcome.
Results: The mean (SD) age was 56 (7.6) years, with 41% male and 74% white. The mean (SD) PM2.5 exposure was 14 (22) mu g/m(3). All inferior leads (II, III, and aVF) and two out of three lateral leads (I and V6), showed a significant association between higher PM2.5 levels and higher ST-height. Most of the adverse effects occurred within two hours after PM2.5 exposure. The multivariable adjusted regression coefficients beta (95% CI) of the cumulative effect due to a 10 mu g/m(3) increase in Lag 0-4 PM2.5 on ST-I, II, III, aVF and ST-V6 were 0.29 (0.01-0.56) mu V, 0.79 (0.20-1.39) mu V, 0.52 (0.01-1.05) mu V, 0.65 (0.11-1.19) mu V, and 0.58 (0.07-1.09) mu V, respectively, with all p < 0.05.
Conclusions: Increased PM2.5 concentration is associated with immediate increase in ST-segment height in inferior and lateral leads, generally within two hours. Such an acute effect of PM2.5 may contribute to increased potential for regional myocardial ischemic injury among healthy individuals.
C1 [He, Fan; Shaffer, Michele L.; Rodriguez-Colon, Sol; Wu, Rongling; Liao, Duanping] Penn State Univ, Coll Med, Dept Publ Hlth Sci, Hershey, PA 17033 USA.
[Bixler, Edward O.; Vgontzas, Alexandros N.] Penn State Univ, Coll Med, Sleep Res & Treatment Ctr, Dept Psychiat, Hershey, PA 17033 USA.
[Williams, Ronald W.] US EPA, Human Exposure & Atmospher Sci Div, Exposure Measurements & Anal Branch, Res Triangle Pk, NC 27711 USA.
[Cascio, Wayne E.] E Carolina Univ, Greenville, NC 27834 USA.
[Cascio, Wayne E.] E Carolina Heart Inst, Greenville, NC 27834 USA.
[Cascio, Wayne E.] Brody Sch Med, Dept Cardiovasc Sci, Greenville, NC 27834 USA.
RP Liao, DP (reprint author), Penn State Univ, Coll Med, Dept Publ Hlth Sci, A210,600 Centerview Dr Suite 2200, Hershey, PA 17033 USA.
EM dliao@psu.edu
FU NIEHS [1 R01 ES014010]
FX This study is funded by NIEHS (1 R01 ES014010). The authors wish to
thank Dr. David Mortara of Mortara Instrument, Inc. for providing the
SuperECG software for the analysis of the electrocardiographic data. The
research described in this article by the United States Environmental
Protection Agency has not been subjected to Agency review and,
therefore, does not necessarily reflect the review of the Agency and no
official endorsement should be inferred.
NR 50
TC 1
Z9 1
U1 0
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1476-069X
J9 ENVIRON HEALTH-GLOB
JI Environ. Health
PD NOV 8
PY 2010
VL 9
AR 68
DI 10.1186/1476-069X-9-68
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA 683IE
UT WOS:000284468200001
PM 21059260
ER
PT J
AU Van Sickle, J
AF Van Sickle, John
TI Correlated Metrics Yield Multimetric Indices with Inferior Performance
SO TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY
LA English
DT Article
ID BIOTIC INTEGRITY; FISH ASSEMBLAGES; BIOLOGICAL CONDITION; RIVER HEALTH;
STREAMS; IBI; INDICATORS; US; ECOSYSTEMS; SCALE
AB Multimetric indices (MMIs) are widely used to assess the ecological health of freshwater ecosystems. An MMI is a sum of several standardized numeric variables or metrics, each representing a different attribute of a biological assemblage. Many researchers believe that highly correlated metrics should not be included in the same MMI because they convey redundant information. To seek evidence for or against this belief, I compared the performance of 1,000 MMIs created for each of eight existing data sets by randomly resampling metrics from sets of previously identified candidates. An MMI's performance was measured by its precision and its ability to detect differences between assemblages sampled in independently assessed reference and impacted streams. Across the 1,000 MMIs, precision decreased with increasing mean correlation magnitude for seven of the eight data sets. For seven of the data sets, multiple linear regressions fitted to each set of 1,000 MMIs predicted a decrease in MMI detection ability as the mean correlation magnitude between metrics increased, after adjusting for the average responsiveness of individual metrics to the difference between reference and impacted conditions. However, similar regressions showed that the size of the largest correlation between any two metrics in an MMI had little or no effect on its detection ability. Thus, minimizing the mean of metric correlations is more effective than the widespread practice of setting an upper correlation limit when optimal MMI performance is desired. Finally, an MMI had originally been built for each data set by selecting one set of individually best metrics. In 23 of 24 assessments, 5-100% of randomly selected MMIs outperformed the original MMIs. Because individually best metrics rarely yielded a best-performing summed index, I recommend assessing multiple candidate MMIs, rather than just multiple candidate metrics, when developing a new MMI.
C1 US EPA, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97333 USA.
RP Van Sickle, J (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, 200 SW 35th St, Corvallis, OR 97333 USA.
EM vansickle.john@epa.gov
FU U.S. Environmental Protection Agency (EPA)
FX I thank Alan Herlihy, John Stoddard, Leska Fore, Bob Hughes, Phil
Kaufmann, and Thom Whittier for their ideas and data. Lester Yuan, Chuck
Hawkins, Bob Hughes, Alan Herlihy, and an anonymous referee provided
valuable comments on the manuscript. This research has been funded by
the U.S. Environmental Protection Agency (EPA). The manuscript has been
subjected to the agency's peer and administrative review and approved
for publication as an EPA document. Mention of trade names or commercial
products does not constitute endorsement or recommendation for use.
NR 46
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U1 0
U2 11
PU AMER FISHERIES SOC
PI BETHESDA
PA 5410 GROSVENOR LANE SUITE 110, BETHESDA, MD 20814-2199 USA
SN 0002-8487
J9 T AM FISH SOC
JI Trans. Am. Fish. Soc.
PD NOV
PY 2010
VL 139
IS 6
BP 1802
EP 1817
DI 10.1577/T09-204.1
PG 16
WC Fisheries
SC Fisheries
GA 704ZE
UT WOS:000286095500017
ER
PT J
AU Nussbaum, BD
AF Nussbaum, Barry D.
TI "Desired and Feared-What Do We Do Now and Over the Next 50 Years?" The
American Statistician, 63,202-210
SO AMERICAN STATISTICIAN
LA English
DT Letter
C1 US EPA, Washington, DC 20460 USA.
RP Nussbaum, BD (reprint author), US EPA, Washington, DC 20460 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER STATISTICAL ASSOC
PI ALEXANDRIA
PA 732 N WASHINGTON ST, ALEXANDRIA, VA 22314-1943 USA
SN 0003-1305
J9 AM STAT
JI Am. Stat.
PD NOV
PY 2010
VL 64
IS 4
BP 362
EP 362
DI 10.1198/tast.2010.10181
PG 1
WC Statistics & Probability
SC Mathematics
GA 709PE
UT WOS:000286451800012
ER
PT J
AU Beumer, A
King, D
Donohue, M
Mistry, J
Covert, T
Pfaller, S
AF Beumer, Amy
King, Dawn
Donohue, Maura
Mistry, Jatin
Covert, Terry
Pfaller, Stacy
TI Detection of Mycobacterium avium subsp. paratuberculosis in Drinking
Water and Biofilms by Quantitative PCR
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID CROHNS-DISEASE; NONTUBERCULOUS MYCOBACTERIA; ENVIRONMENTAL-SAMPLES;
UNITED-STATES; EPIDEMIOLOGY; IDENTIFICATION; INTRACELLULARE;
METAANALYSIS; INFECTION; NUMBERS
AB It has been suggested that Mycobacterium avium subspecies paratuberculosis has a role in Crohn's disease. The organism may be acquired but is difficult to culture from the environment. We describe a quantitative PCR (qPCR) method to detect M. avium subsp. paratuberculosis in drinking water and the results of its application to drinking water and faucet biofilm samples collected in the United States.
C1 [King, Dawn; Donohue, Maura; Pfaller, Stacy] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
[Beumer, Amy] Univ Cincinnati, Raymond Walters Coll, Blue Ash, OH 45236 USA.
[Mistry, Jatin] US EPA, Dallas, TX 75202 USA.
[Covert, Terry] Shaw Environm & Infrastruct Grp, Cincinnati, OH 45268 USA.
RP Pfaller, S (reprint author), US EPA, Natl Exposure Res Lab, Mail Stop 314,26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM pfaller.stacy@epa.gov
FU U.S. Department of Energy; EPA
FX This research was supported in part by an appointment to the
Postgraduate Research Participation Program administered by the Oak
Ridge Institute for Science and Education through an interagency
agreement between the U.S. Department of Energy and the EPA. The EPA,
through its Office of Research and Development, funded and managed the
research described here. This research has been subjected to the
agency's administrative review and has been approved for publication.
NR 27
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U1 1
U2 22
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD NOV
PY 2010
VL 76
IS 21
BP 7367
EP 7370
DI 10.1128/AEM.00730-10
PG 4
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA 670PM
UT WOS:000283439800057
PM 20817803
ER
PT J
AU Geron, CD
Arnts, RR
AF Geron, Chris D.
Arnts, Robert R.
TI Seasonal monoterpene and sesquiterpene emissions from Pinus taeda and
Pinus virginiana
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Seasonality; Monoterpene; Sesquiterpene; Emissions; Pinus taeda; Pinus
virginiana; Loblolly Pine; Virginia Pine; Beta caryophyllene; Alpha
pinene; North Carolina
ID ORGANIC-COMPOUND EMISSIONS; VEGETATION ENCLOSURE TECHNIQUES;
SOUTHEASTERN US; VOC EMISSIONS; UNITED-STATES; SCOTS PINE; FORESTS;
AEROSOL; CARBON; LIGHT
AB Seasonal volatile organic compound emission data from loblolly pine (Pinus taeda) and Virginia pine (Pinus virginiana) were collected using branch enclosure techniques in Central North Carolina, USA. P. taeda monoterpene emission rates were at least ten times higher than oxygenated monoterpene and sesquiterpene emissions in all seasons. alpha-pinene and gamma-pinene were the most abundant emissions, while beta-caryophyllene had the highest sesquiterpene emission rate from this species. beta-phellandrene was the dominant compound emitted from P. virginiana, followed by the sesquiterpene beta-caryophyllene. Sesquiterpene emissions from P. virginiana have not been reported in the literature previously. Summer sesquiterpene emissions from P. virginiana were nearly as high as monoterpene emissions, but were 4 -12 times lower than monoterpene emissions in the other seasons. Oxygenated monoterpenes and 2-methyl-3-buten-2-ol were emitted at higher rates from P. taeda than from P. virginiana. Temperature response of the pinenes from P. taeda is similar to previously reported values used in emission models, while that for other compounds falls at the lower end of the previously reported range. Temperature response of all compounds from P. virginiana is in reasonable agreement with previously reported values from other pine species. There is evidence of light dependence of sesquiterpene emission after accounting for temperature response from both species. This effect is somewhat stronger in P. taeda. Bud break, needle expansion, and needle fall (and therefore wind events) seemed to increase monoterpene emission during non-summer seasons. In some instances springtime monoterpene emissions were higher than summertime emissions despite cooler temperatures. Emissions of individual compounds within monoterpene, oxygenated monoterpene, and sesquiterpene classes were highly correlated with each other. Compounds from different classes were much less correlated within each species. This is due to a varying temporal emission patterns for each BVOC class and suggests different production, storage, and emission controls for each. Analysis of enclosure blanks and diurnal patterns indicates that, despite precautions, disturbance due to the enclosure technique may still impact monoterpene emission rate estimates. This did not appear to affect sesquiterpene emissions. Published by Elsevier Ltd.
C1 [Geron, Chris D.] US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
[Arnts, Robert R.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Geron, CD (reprint author), US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
EM geron.chris@epa.gov
OI Geron, Chris/0000-0002-4266-2155
NR 22
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U1 1
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD NOV
PY 2010
VL 44
IS 34
BP 4240
EP 4251
DI 10.1016/j.atmosenv.2010.06.054
PG 12
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 663WW
UT WOS:000282921900012
ER
PT J
AU Watt, MS
Kriticos, DJ
Potter, KJB
Manning, LK
Tallent-Halsell, N
Bourdot, GW
AF Watt, Michael S.
Kriticos, Darren J.
Potter, Karina J. B.
Manning, Lucy K.
Tallent-Halsell, Nita
Bourdot, Graeme W.
TI Using species niche models to inform strategic management of weeds in a
changing climate
SO BIOLOGICAL INVASIONS
LA English
DT Article
DE Buddleia davidii; Butterfly bush; Climate change; CLIMEX; Invasive alien
species; Spread; Weed risk
ID FUTURE POTENTIAL DISTRIBUTION; POPULATION-DYNAMICS MODEL;
BIOLOGICAL-CONTROL AGENT; INVASIVE ALIEN PLANT; YOUNG PINUS-RADIATA;
NEW-ZEALAND; VEGETATION MANAGEMENT; BUDDLEJA-DAVIDII; ACACIA-NILOTICA;
GROWTH
AB The expansion of the global area planted in fast-growing forest species seems likely as a means of offsetting carbon dioxide emissions and developing a sustainable bio-energy resource. Selecting appropriate sites for these plantations will require consideration of the effect of climate change on plantation growth and risks from abiotic and biotic factors. Buddleja davidii has been identified as a weed that has a major impact on plantation forest production in New Zealand. While it is at present restricted mainly to the North Island, a large proportion of the area identified for forest expansion is in eastern and southern regions of the South Island where the weed is presently relatively scarce. In this study we use a process-oriented climatic niche model (CLIMEX) to identify climatically suitable areas for B. davidii under current climate and future climate during the 2080s. This analysis indicates areas most at risk from invasion by B. davidii are in eastern and southern regions of the South Island. As B. davidii predominantly colonises disturbed areas, the likely increases in plantation forest area within this region can be expected to promote the spread of B. davidii. Strategies that could be implemented to manage B. davidii in this region are discussed. This study highlights the general utility of process-oriented niche models in identifying possible threats to planned primary production activities from invasive weed species. This type of knowledge is invaluable in planning and allocation of often scarce resources to most effectively control high impact weeds. Without the synoptic view of the invasion and the assets at risk, there is a strong potential for regional pest management to be parochial, and consequently less effective at all scales.
C1 [Watt, Michael S.] Scion, Christchurch, New Zealand.
[Kriticos, Darren J.] CSIRO Entomol & Climate Adaptat Flagship, Canberra, ACT 2601, Australia.
[Potter, Karina J. B.] CSIRO Sustainable Ecosyst, Hobart, Tas 7007, Australia.
[Potter, Karina J. B.] CRC Forestry, Hobart, Tas 7007, Australia.
[Manning, Lucy K.] Scion, Rotorua, New Zealand.
[Tallent-Halsell, Nita] US EPA, Landscape Ecol Branch, Las Vegas, NV 89119 USA.
[Bourdot, Graeme W.] AgResearch, Christchurch 8140, New Zealand.
RP Watt, MS (reprint author), Scion, POB 29237, Christchurch, New Zealand.
EM michael.watt@scionresearch.com
RI Potter, Karina/D-3565-2011; Watt, Michael/C-3813-2009; Kriticos,
Darren/A-4170-2008; Bourdot, Graeme/J-7582-2013
OI Kriticos, Darren/0000-0003-2599-8105;
FU MAF [C04X0901]; Foundation for Research Science and Technology, New
Zealand [C10X0811]
FX We thank MAF (Contract No. C04X0901) and the Foundation for Research
Science and Technology (Contract No. C10X0811), New Zealand, for funding
this research. We are also very grateful to Peter Hall, Barbara Hock,
and the rest of the team that produced the Bioenergy Options report, for
allowing us to use the afforestation scenarios. The U. S. Environmental
Protection Agency through its Office of Research and Development
collaborated in the research. This manuscript has been subject to Agency
peer review and approved for publication. Mention of trade names or
commercial products does not constitute an endorsement or recommendation
for use.
NR 53
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Z9 8
U1 1
U2 28
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1387-3547
J9 BIOL INVASIONS
JI Biol. Invasions
PD NOV
PY 2010
VL 12
IS 11
BP 3711
EP 3725
DI 10.1007/s10530-010-9764-1
PG 15
WC Biodiversity Conservation; Ecology
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 711HX
UT WOS:000286581200006
ER
PT J
AU Upadhyayula, VKK
Gadhamshetty, V
AF Upadhyayula, Venkata K. K.
Gadhamshetty, Venkataramana
TI Appreciating the role of carbon nanotube composites in preventing
biofouling and promoting biofilms on material surfaces in environmental
engineering: A review
SO BIOTECHNOLOGY ADVANCES
LA English
DT Review
DE Carbon nanotubes; Nanocomposites; Biofouling; Superhydrophobic;
Biofilms; Microbial fuel cells
ID MICROBIAL FUEL-CELLS; POLYCYCLIC AROMATIC-HYDROCARBONS; GRAM-NEGATIVE
BACTERIA; LARGE-SCALE PRODUCTION; ESCHERICHIA-COLI; ADSORPTION
EQUILIBRIUM; ANTIMICROBIAL ACTIVITY; STAPHYLOCOCCUS-AUREUS; SILVER
NANOPARTICLES; METAL NANOPARTICLES
AB The ability of carbon nanotubes (CNTs) to undergo surface modification allows them to form nanocomposites (NCs) with materials such as polymers, metal nanoparticles, biomolecules, and metal oxides. The biocidal nature, protein fouling resistance, and fouling release properties of CNT-NCs render them the perfect material for biofouling prevention. At the same time, the cytotoxicity of CNT-NCs can be reduced before applying them as substrates to promote biofilm formation in environmental biotechnology applications. This paper reviews the potential prospects of CNT-NCs to accomplish two widely varying objectives in environmental engineering applications: (i) preventing biofouling, and (ii) promoting the formation of desirable biofilms on materials surface. This paper addresses practical issues such as costs, risks to human health, and ecological impacts that are associated with the application, development and commercialization of CNT-NC technology. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Upadhyayula, Venkata K. K.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37831 USA.
[Gadhamshetty, Venkataramana] Rensselaer Polytech Inst, Dept Civil & Environm Engn, Troy, NY 12180 USA.
RP Upadhyayula, VKK (reprint author), US EPA, 26 W Martin Luther King Jr Dr, Cincinnati, OH 45268 USA.
EM Upadhyayula.Venkata@epa.gov
RI Gadhamshetty, Venkataramana/B-5609-2009; Upadhyayula, Venkata
Krishna/E-7549-2012
NR 154
TC 58
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U1 5
U2 98
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0734-9750
EI 1873-1899
J9 BIOTECHNOL ADV
JI Biotechnol. Adv.
PD NOV-DEC
PY 2010
VL 28
IS 6
BP 802
EP 816
DI 10.1016/j.biotechadv.2010.06.006
PG 15
WC Biotechnology & Applied Microbiology
SC Biotechnology & Applied Microbiology
GA 671RH
UT WOS:000283526500014
PM 20599491
ER
PT J
AU Erickson, RJ
Mount, DR
Highland, TL
Hockett, JR
Leonard, EN
Mattson, VR
Dawson, TD
Lott, KG
AF Erickson, Russell J.
Mount, David R.
Highland, Terry L.
Hockett, J. Russell
Leonard, Edward N.
Mattson, Vincent R.
Dawson, Timothy D.
Lott, Kevin G.
TI Effects of copper, cadmium, lead, and arsenic in a live diet on juvenile
fish growth
SO CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES
LA English
DT Article
ID TROUT ONCORHYNCHUS-MYKISS; CLARK-FORK RIVER; RAINBOW-TROUT; CHRONIC
TOXICITY; LUMBRICULUS-VARIEGATUS; BENTHIC INVERTEBRATES; CHANNEL
CATFISH; SALMO-GAIRDNERI; EXPOSURE; WATER
AB The effects of diet-borne copper, cadmium, lead, and arsenic on juvenile fish were evaluated using a live diet consisting of the oligochaete Lumbriculus variegatus. In 30 d exposures, no effects were observed on the growth and survival of rainbow trout (Oncorhynchus mykiss), fathead minnow (Pimephales promelas), and channel catfish (Ictalurus punctatus) fed diets contaminated with copper [130-310 mu g Cu.(g dm)(-1)], cadmium [90-540 mu g Cd.(g dm)(-1)], and lead [850-1000 mu g Pb.(g dm)(-1)]. However, rainbow trout growth was reduced in a dose-dependent manner for diets contaminated with arsenic [26-77 mu g As.(g dm)(-1)]. These effects of arsenic on fish growth were accompanied by slower feeding rate, reduced food conversion efficiency, liver cell abnormalities, and fecal matter changes suggestive of digestive effects, and occurred to a similar extent whether the diet was exposed to arsenate or arsenite. Effects from these dietary levels of arsenic, and the absence of effects from these dietary levels of metals, were generally consistent with literature reports using laboratory diets amended with toxicant salts. These results also indicated that reported growth effects on rainbow trout fed diets of invertebrates collected from mining-contaminated areas of the Clark Fork River (Montana, USA) or exposed in the laboratory to Clark Fork River sediments are likely more attributable to the arsenic than the metals in those diets.
C1 [Erickson, Russell J.; Mount, David R.; Highland, Terry L.; Hockett, J. Russell; Leonard, Edward N.; Mattson, Vincent R.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA.
[Dawson, Timothy D.; Lott, Kevin G.] Sobran Inc, Duluth, MN 55802 USA.
RP Erickson, RJ (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA.
EM erickson.russell@epa.gov
NR 25
TC 12
Z9 13
U1 9
U2 39
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 1200 MONTREAL ROAD, BUILDING M-55, OTTAWA, ON K1A 0R6, CANADA
SN 0706-652X
J9 CAN J FISH AQUAT SCI
JI Can. J. Fish. Aquat. Sci.
PD NOV
PY 2010
VL 67
IS 11
BP 1816
EP 1826
DI 10.1139/F10-098
PG 11
WC Fisheries; Marine & Freshwater Biology
SC Fisheries; Marine & Freshwater Biology
GA 676OG
UT WOS:000283921200010
ER
PT J
AU Kim, TH
Chiera, SL
Linder, KE
Trempus, CS
Smart, RC
Horowitz, JM
AF Kim, Tae-Hyung
Chiera, Shannon L.
Linder, Keith E.
Trempus, Carol S.
Smart, Robert C.
Horowitz, Jonathan M.
TI Overexpression of Transcription Factor Sp2 Inhibits Epidermal
Differentiation and Increases Susceptibility to Wound- and
Carcinogen-Induced Tumorigenesis
SO CANCER RESEARCH
LA English
DT Article
ID HAIR FOLLICLE BULGE; ROUS-SARCOMA-VIRUS; TRANSGENIC MICE;
EMBRYONIC-DEVELOPMENT; STEM-CELLS; FACTOR FAMILY; EXPRESSION; MOUSE;
GROWTH; PROLIFERATION
AB Sp proteins are evolutionarily conserved transcription factors required for the expression of a wide variety of genes that are critical for development and cell cycle progression. Deregulated expression of certain Sp proteins is associated with the formation of a variety of human tumors; however, direct evidence that any given Sp protein is oncogenic has been lacking. Here, we report that Sp2 protein abundance in mice increases in concert with the progression of carcinogen-induced murine squamous cell carcinomas. Transgenic mice specifically overexpressing murine Sp2 in epidermal basal keratinocytes were highly susceptible to wound-and carcinogen-induced papillomagenesis. Transgenic animals that were homozygous rather than hemizygous for the Sp2 transgene exhibited a striking arrest in the epidermal differentiation program, perishing within 2 weeks of birth. Our results directly support the likelihood that Sp2 overexpression occurring in various human cancers has significant functional effect. Cancer Res; 70(21); 8507-16. (C)2010 AACR.
C1 [Kim, Tae-Hyung; Chiera, Shannon L.; Horowitz, Jonathan M.] N Carolina State Univ, Dept Mol Biomed Sci, Raleigh, NC 27606 USA.
[Kim, Tae-Hyung; Chiera, Shannon L.; Linder, Keith E.; Smart, Robert C.; Horowitz, Jonathan M.] N Carolina State Univ, Ctr Comparat Med & Translat Res, Raleigh, NC 27606 USA.
[Linder, Keith E.] N Carolina State Univ, Dept Populat Hlth & Pathobiol, Coll Vet Med, Raleigh, NC 27606 USA.
[Smart, Robert C.] N Carolina State Univ, Cell Signaling & Canc Grp, Dept Environm & Mol Toxicol, Raleigh, NC 27606 USA.
[Trempus, Carol S.] Natl Inst Environm Hlth Sci, Metab & Mol Mech Grp, Lab Toxicol & Pharmacol, NIH, Res Triangle Pk, NC USA.
RP Horowitz, JM (reprint author), N Carolina State Univ, Dept Mol Biomed Sci, CVM Res Bldg,Room 354,4700 Hillsborough St, Raleigh, NC 27606 USA.
EM jon_horowitz@ncsu.edu
FU National Cancer Institute [CA105313]; National Institute of General
Medical Sciences [GM065405]; Jimmy V-NCSU Cancer Therapeutics Training
Program
FX National Cancer Institute grant CA105313, National Institute of General
Medical Sciences grant GM065405, and funds supplied by the Jimmy V-NCSU
Cancer Therapeutics Training Program.
NR 45
TC 8
Z9 8
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
J9 CANCER RES
JI Cancer Res.
PD NOV 1
PY 2010
VL 70
IS 21
BP 8507
EP 8516
DI 10.1158/0008-5472.CAN-10-1213
PG 10
WC Oncology
SC Oncology
GA 673MJ
UT WOS:000283667300029
PM 20959487
ER
PT J
AU Tokar, EJ
Benbrahim-Tallaa, L
Ward, JM
Lunn, R
Sams, RL
Waalkes, MP
AF Tokar, Erik J.
Benbrahim-Tallaa, Lamia
Ward, Jerrold M.
Lunn, Ruth
Sams, Reeder L., II
Waalkes, Michael P.
TI Cancer in experimental animals exposed to arsenic and arsenic compounds
SO CRITICAL REVIEWS IN TOXICOLOGY
LA English
DT Review
DE Arsenicals; carcinogenesis; inhalation; mouse; oral exposure; rat;
rodents; transplacental exposure
ID MALE F344 RATS; DIMETHYLARSINIC ACID; MAIN METABOLITE; URINARY-BLADDER;
DRINKING-WATER; MOUSE SKIN; INORGANIC ARSENICS; LUNG-CANCER; IN-UTERO;
POSTNATAL DIETHYLSTILBESTROL
AB Inorganic arsenic is a ubiquitous environmental contaminant that has long been considered a human carcinogen. Recent studies raise further concern about the metalloid as a major, naturally occurring carcinogen in the environment. However, during this same period it has proven difficult to provide experimental evidence of the carcinogenicity of inorganic arsenic in laboratory animals and, until recently, there was considered to be a lack of clear evidence for carcinogenicity of any arsenical in animals. More recent work with arsenical methylation metabolites and early life exposures to inorganic arsenic has now provided evidence of carcinogenicity in rodents. Given that tens of millions of people worldwide are exposed to potentially unhealthy levels of environmental arsenic, in vivo rodent models of arsenic carcinogenesis are a clear necessity for resolving critical issues, such as mechanisms of action, target tissue specificity, and sensitive subpopulations, and in developing strategies to reduce cancers in exposed human populations. This work reviews the available rodent studies considered relevant to carcinogenic assessment of arsenicals, taking advantage of the most recent review by the International Agency for Research on Cancer (IARC) that has not yet appeared as a full monograph but has been summarized (IARC, 2009, IARC Special Report: Policy, Vol. 10. Lyon: IARC Press, 453-454). Many valid studies show that arsenic can interact with other carcinogens/agents to enhance oncogenesis, and help elucidate mechanisms, and these too are summarized in this review. Finally, this body of rodent work is discussed in light of its impact on mechanisms and in the context of the persistent argument that arsenic is not carcinogenic in animals.
C1 [Lunn, Ruth; Waalkes, Michael P.] NIEHS, Natl Toxicol Program, Report Carcinogens Off, Res Triangle Pk, NC 27709 USA.
[Tokar, Erik J.; Waalkes, Michael P.] NIEHS, Comparat Carcinogenesis Lab, NCI, Res Triangle Pk, NC 27709 USA.
[Benbrahim-Tallaa, Lamia] Int Agcy Res Canc, IARC Monographs Sect, F-69372 Lyon, France.
[Ward, Jerrold M.] Global VetPathol, Montgomery Village, MD USA.
[Sams, Reeder L., II] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Waalkes, MP (reprint author), NIEHS, Natl Toxicol Program, Report Carcinogens Off, POB 12233,Mail Drop F0-09,111 Alexander Dr, Res Triangle Pk, NC 27709 USA.
EM waalkes@niehs.nih.gov
FU NIH, National Cancer Institute, Center for Cancer Research; NIEHS
FX The authors' employment affiliations are as shown on the first page.
This research was supported by the Intramural Research Program of the
NIH, National Cancer Institute, Center for Cancer Research, and the
National Toxicology Program, NIEHS. This article is the work product of
an employee or group of employees of the NIEHS, NIH; however, the
statements, opinions, or conclusions contained therein do not
necessarily represent the statements, opinions, or conclusions of the
NIEHS, NIH, or the United States Government. The authors alone are
responsible for the content and writing of the paper. The content of
this publication does not necessarily reflect the views or policies of
the Department of Health and Human Services.
NR 71
TC 53
Z9 57
U1 1
U2 24
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1040-8444
J9 CRIT REV TOXICOL
JI Crit. Rev. Toxicol.
PD NOV
PY 2010
VL 40
IS 10
BP 912
EP 927
DI 10.3109/10408444.2010.506641
PG 16
WC Toxicology
SC Toxicology
GA 664NF
UT WOS:000282967700003
PM 20812815
ER
PT J
AU Blakeslee, AMH
McKenzie, CH
Darling, JA
Byers, JE
Pringle, JM
Roman, J
AF Blakeslee, A. M. H.
McKenzie, C. H.
Darling, J. A.
Byers, J. E.
Pringle, J. M.
Roman, J.
TI A hitchhiker's guide to the Maritimes: anthropogenic transport
facilitates long-distance dispersal of an invasive marine crab to
Newfoundland
SO DIVERSITY AND DISTRIBUTIONS
LA English
DT Editorial Material
DE Anthropogenic introduction; biological invasions; Carcinus maenas;
microsatellite loci; mitochondrial DNA; Newfoundland; north-west
Atlantic
ID CARCINUS-MAENAS; POPULATION-STRUCTURE; NORTH-AMERICA; BIOLOGICAL
INVASIONS; ST-LAWRENCE; GREEN CRAB; PATTERNS; EXPANSION; GENOTYPE;
GENETICS
AB Aim
To determine timing, source and vector for the recent introduction of the European green crab, Carcinus maenas (Linnaeus, 1758), to Newfoundland using multiple lines of evidence.
Location
Founding populations in Placentia Bay, Newfoundland, Canada and potential source populations in the north-west Atlantic (NWA) and Europe.
Methods
We analysed mitochondrial and microsatellite genetic data from European and NWA populations sampled during 1999-2002 to determine probable source locations and vectors for the Placentia Bay introduction discovered in 2007. We also analysed Placentia Bay demographic data and shipping records to look for congruent patterns with genetic analyses.
Results
Demographic data and surveys suggested that C. maenas populations are established and were in Placentia Bay for several years (c. 2002) prior to discovery. Genetic data corroboratively suggested central/western Scotian Shelf populations (e.g., Halifax) as the likely source area for the anthropogenic introduction. These Scotian Shelf populations were within an admixture zone made up of genotypes from both the earlier (early 1800s) and later (late 1900s) introductions of the crab to the NWA from Europe. Placentia Bay also exhibited this mixed ancestry. Probable introduction vectors included vessel traffic and shipping, especially vessels carrying ballast water.
Main conclusions
Carcinus maenas overcame considerable natural barriers (i.e., coastal and ocean currents) via anthropogenic transport to become established and abundant in Newfoundland. Our study thus demonstrates how non-native populations can be important secondary sources of introduction especially when aided by human transport. Inference of source populations was possible owing to the existence of an admixture zone in central/western Nova Scotia made up of southern and northern genotypes corresponding with the crab's two historical introductions. Coastal vessel traffic was found to be a likely vector for the crab's spread to Newfoundland. Our study demonstrates that there is considerable risk for continued introduction or reintroduction of C. maenas throughout the NWA.
C1 [Blakeslee, A. M. H.] Smithsonian Environm Res Ctr, Marine Invas Lab, Edgewater, MD 21037 USA.
[McKenzie, C. H.] Fisheries & Oceans Canada, Fisheries & Oceans Canada, St John, NF A1C 5X1, Canada.
[Darling, J. A.] US EPA, Mol Ecol Res Branch, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
[Byers, J. E.] Univ Georgia, Odum Sch Ecol, Athens, GA 30602 USA.
[Pringle, J. M.] Univ New Hampshire, Inst Study Earth Ocean & Space, Durham, NH 03824 USA.
[Roman, J.] Univ Vermont, Gund Inst Ecol Econ, Burlington, VT 05443 USA.
RP Blakeslee, AMH (reprint author), Smithsonian Environm Res Ctr, Marine Invas Lab, POB 28, Edgewater, MD 21037 USA.
EM blakesleea@si.edu
NR 39
TC 44
Z9 44
U1 3
U2 39
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1366-9516
EI 1472-4642
J9 DIVERS DISTRIB
JI Divers. Distrib.
PD NOV
PY 2010
VL 16
IS 6
BP 879
EP 891
DI 10.1111/j.1472-4642.2010.00703.x
PG 13
WC Biodiversity Conservation; Ecology
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 669UO
UT WOS:000283375900001
ER
PT J
AU Collins, KA
Lawrence, TJ
Stander, EK
Jontos, RJ
Kaushal, SS
Newcomer, TA
Grimm, NB
Ekberg, MLC
AF Collins, Kelly A.
Lawrence, Timothy J.
Stander, Emilie K.
Jontos, Robert J.
Kaushal, Sujay S.
Newcomer, Tamara A.
Grimm, Nancy B.
Ekberg, Marci L. Cole
TI Opportunities and challenges for managing nitrogen in urban stormwater:
A review and synthesis
SO ECOLOGICAL ENGINEERING
LA English
DT Article
DE Stormwater; Nitrogen; Nitrate; Denitrification; Uptake; NPDES
regulations
ID POLLUTANT REMOVAL PERFORMANCE; LOW-IMPACT DEVELOPMENT; WATER NITRATE
REMOVAL; NORTH-CAROLINA; BIOFILTRATION SYSTEMS; CONSTRUCTED WETLANDS;
BIORETENTION MEDIA; DETENTION PONDS; RUNOFF WATER; RAIN GARDEN
AB Although nitrogen (N) is prevalent in urban stormwater, regulation of this pollutant has occurred only more recently. This paper reviews the concerns over N in urban stormwater, mechanisms and design enhancements for N uptake and denitrification through various stormwater control measures (SCMs), and presents opportunities to integrate this current knowledge into the regulatory framework. A survey of personnel directly involved in various aspects of US state and territory NPDES programs revealed that the top three pollutants of concern were total suspended solids (TSS), pathogens and bacteria, and total phosphorus (TP). Surprisingly, nitrate (NO(3)(-)) was of little concern among the survey respondents, with 3.9% giving it the highest level of concern, 2.0% ranking it second, and 6.0% ranking it third. When asked which strategies were currently used in their geographic area for stormwater management, the most common results were wet ponds and dry ponds. At the same time, wet ponds and dry ponds were recognized as less effective practices to manage stormwater.
A review of current literature reveals that several alternative SCMs, such as bioretention, filters, and wetlands, show greater promise in their ability to remove N from stormwater than more conventional practices such as dry ponds and wet ponds. Enhanced N removal via denitrification and plant uptake is often observed under the combination of aerobic followed by sustained anoxic conditions, the presence of a carbon source (organic material), and the presence of mature, dense vegetation.
Given the lack of concern or awareness of local officials related to N loading from urban stormwater, and variation in the efficacy of various SCMs, it is not surprising that regulators remain focused on conventional dry pond and wet pond control measures. More needs to be done to quantify the impact of urban sources of Non water quality and aquatic ecosystems. In addition, greater focus needs to be placed on the development of design criteria for SCMs, such as bioretention, filters, and constructed wetlands, which show more promise for N removal. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Collins, Kelly A.] Ctr Watershed Protect Inc, Ellicott City, MD USA.
[Lawrence, Timothy J.] Washington State Univ Extens, Coupeville, WA USA.
[Stander, Emilie K.] US EPA, Urban Watershed Management Branch, Edison, NJ USA.
[Jontos, Robert J.] Land Tech Consultants Inc, Southbury, CT USA.
[Kaushal, Sujay S.] Univ Maryland, Chesapeake Biol Lab, Ctr Environm Sci, Solomons, MD 20688 USA.
[Newcomer, Tamara A.] Univ Maryland, College Pk, MD 20742 USA.
[Grimm, Nancy B.] Arizona State Univ, Tempe, AZ 85287 USA.
[Ekberg, Marci L. Cole] Save Bay, Narragansett Bay, Providence, RI USA.
RP Collins, KA (reprint author), Ctr Watershed Protect Inc, Ellicott City, MD USA.
EM kac@cwp.org; timothy.lawrence@wsu.edu; stander.emilie@epa.gov;
rjontos1@landtechconsult.com; kaushal@umces.edu; newcomer@cbl.umces.edu;
nbgrimm@asu.edu; mcole@savebay.org
RI Newcomer, Tamara/E-5561-2011; Grimm, Nancy/D-2840-2009; Newcomer
Johnson, Tamara/D-1045-2013; Kaushal, Sujay/G-1062-2013
OI Grimm, Nancy/0000-0001-9374-660X; Newcomer Johnson,
Tamara/0000-0002-2496-7641; Kaushal, Sujay/0000-0003-0834-9189
FU Denitrification Research Coordination Network of the National Science
Foundation [DEB0443439]; USDA [2008-51130-19504]
FX This paper is a product of a workshop on "Denitrification in Managed
Ecosystems" held May 12-14,2009, at the University of Rhode Island Bay
Campus, Narragansett, RI, with support from the Denitrification Research
Coordination Network of the National Science Foundation, award
DEB0443439 and the USDA CSREES Northeast States and Caribbean Islands
Regional Water Project award 2008-51130-19504.
NR 108
TC 78
Z9 85
U1 17
U2 207
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0925-8574
J9 ECOL ENG
JI Ecol. Eng.
PD NOV
PY 2010
VL 36
IS 11
SI SI
BP 1507
EP 1519
DI 10.1016/j.ecoleng.2010.03.015
PG 13
WC Ecology; Engineering, Environmental; Environmental Sciences
SC Environmental Sciences & Ecology; Engineering
GA 665BS
UT WOS:000283010600002
ER
PT J
AU Oakley, SM
Gold, AJ
Oczkowski, AJ
AF Oakley, Stewart M.
Gold, Arthur J.
Oczkowski, Autumn J.
TI Nitrogen control through decentralized wastewater treatment: Process
performance and alternative management strategies
SO ECOLOGICAL ENGINEERING
LA English
DT Article
DE Nitrogen removal; Decentralized wastewater treatment; Denitrification
ID SEPTIC-SYSTEM PLUME; NITRATE; GROUNDWATER; EFFLUENT; FILTER; TANK;
DENITRIFICATION; CONTAMINATION; RELIABILITY; NUTRIENT
AB Decentralized or onsite wastewater treatment (OWT) systems have long been implicated in being a major source of N inputs to surface and ground waters and numerous regulatory bodies have promulgated strict total N (TN) effluent standards in N-sensitive areas. These standards, however, most of which have effluent limitations of <10 mg/L TN. were generally developed without data on treatment performance and attainable compliance levels of operating OWTs designed to remove N. This paper reviews OWT technologies that rely on preanoxic or postanoxic denitrification, or simultaneous nitrification-denitrification, and frequently include compact, mechanized components. TN effluent data from 20 OWTs in 3 long-term N removal demonstration projects in Florida, Oregon, and New Zealand are analyzed and compared with the performance of 15 centralized N removal treatment plants from the US and Canada. A reliability and stability analysis shows that only one of the 20 OWTs approaches the reliability and stability of centralized plants, and can comply with a <10 mg/L TN effluent standard with a 99% probability; all of the remaining 19 OWTs have a <50% probability of compliance. The lower reliability of OWTs, many of which are energy-intensive, scaled-down models of centralized plants, is due to the inherent variability of decentralized wastewater characteristics and the challenges of operationally controlling N removal processes at the level of residences. However, the small footprint (required land area) of these compact designs offers important opportunities for retrofitting OWTs on small lots, in shoreline developments where land is at a premium and where communities wish to foster and sustain compact, village developments that reflect "smart growth" strategies. Other approaches to decentralized N management emphasizing passive, robust, ecologically engineered designs are reviewed and include natural wastewater treatment systems such as single pass sand filters with denitrifying bioreactors, which performed better than any other OWT technology; shallow trenches and drip irrigation for denitrification or plant N uptake in the carbon-rich root zone: denitrification beds/layers installed down gradient from effluent plumes; and the consideration of watershed N sinks in estimating the risks of N loading to receiving waters. These alternative approaches require further research and development, but can offer alternatives or additional treatment to mechanized OWTs. More comparative studies of long-term operation of OWTs under field conditions in other parts of the world are needed to further quantify performance capabilities. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Oakley, Stewart M.] Calif State Univ Chico, Dept Civil Engn, Chico, CA 95929 USA.
[Gold, Arthur J.] Univ Rhode Isl, Dept Nat Resources Sci, Kingston, RI 02881 USA.
[Oczkowski, Autumn J.] US EPA, Atlantic Ecol Div, Narragansett, RI 02882 USA.
RP Oakley, SM (reprint author), Calif State Univ Chico, Dept Civil Engn, Chico, CA 95929 USA.
EM soakley@csuchico.edu; agold@uri.edu; oczkowski.autumn@epa.gov
OI Oczkowski, Autumn/0000-0002-2421-0956
FU Denitrification Research Coordination Network of the National Science
Foundation [DEB0443439]; USDA [2008-51130-19504]
FX This paper is a product of the workshop "Denitrification in Managed
Ecosystems" held May 12-14, 2009, at the University of Rhode Island Bay
Campus, Narragansett, RI, with support from the Denitrification Research
Coordination Network of the National Science Foundation, award
DEB0443439, and the USDA CSREES Northeast States and Caribbean Islands
Regional Water Project, award 2008-51130-19504.
NR 71
TC 33
Z9 33
U1 2
U2 70
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0925-8574
J9 ECOL ENG
JI Ecol. Eng.
PD NOV
PY 2010
VL 36
IS 11
SI SI
BP 1520
EP 1531
DI 10.1016/j.ecoleng.2010.04.030
PG 12
WC Ecology; Engineering, Environmental; Environmental Sciences
SC Environmental Sciences & Ecology; Engineering
GA 665BS
UT WOS:000283010600003
ER
PT J
AU Birnbaum, LS
Staskal-Wikoff, DS
AF Birnbaum, L. S.
Staskal-Wikoff, D. S.
TI 5th international PCB workshop - Summary and implications
SO ENVIRONMENT INTERNATIONAL
LA English
DT Editorial Material
DE PCB; Workshop
AB A summation of new and novel findings presented at "The Fifth PCB Workshop: New Knowledge Gained from Old Pollutants" workshop is provided in this overview, along with discussion of data gaps and research needs in the future. Relative to the previous workshop, the scientific presentations had a decreased emphasis on toxicology; rather, more than half of the sessions dealt with environmental sources, fate and transport, or transformations. Approximately 100 presentations in the form of talks and posters were included in the workshop. The presentations were generally divided into: emissions and transport of PCBs in natural and urban settings; chiral aspects of PCB transport; metabolism and distribution; new aspects of environmental metabolism of PCBs - from microbes to plants to animals; reproduction, developmental and cardiovascular effects of PCBs; updates on Anniston - the most highly exposed PCB community in the U.S. to date; and new and novel approaches for evaluating PCB mixtures (e.g., PCB toxic equivalency factors, and TEFs) - and the implications of such for risk assessment. An overarching state-of-the-science view is important to the goal of preventing negative health consequences. Currently, there are still many roadblocks to evaluating risk associated with this large group of 209 congeners - all of which have different physiochemical properties, variable fate and transport mechanism in the environment, and a range of ability for persistence, bioaccumulation, and biological activity. (C) 2010 Elsevier Ltd. All rights reserved,
C1 [Staskal-Wikoff, D. S.] ToxStrategies, Austin, TX 78741 USA.
[Birnbaum, L. S.] Natl Inst Environm Hlth Sci, Off Director, Durham, NC 27709 USA.
RP Staskal-Wikoff, DS (reprint author), ToxStrategies, 3420 Execut Ctr Dr,Suite 114, Austin, TX 78741 USA.
EM dstaskal@toxstrategies.com
NR 0
TC 6
Z9 6
U1 1
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
J9 ENVIRON INT
JI Environ. Int.
PD NOV
PY 2010
VL 36
IS 8
SI SI
BP 814
EP 818
DI 10.1016/j.envint.2010.06.011
PG 5
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 677HO
UT WOS:000283979900002
PM 20728937
ER
PT J
AU Claxton, LD
Umbuzeiro, GD
DeMarini, DM
AF Claxton, Larry D.
Umbuzeiro, Gisela de A.
DeMarini, David M.
TI The Salmonella Mutagenicity Assay: The Stethoscope of Genetic Toxicology
for the 21st Century
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Review
DE Ames assay; carcinogenicity; 21st century toxicology; genetic
toxicology; high-throughput assays; Salmonella assay; Salmonella
mutagenicity assay
ID HEALTH-RISK ASSESSMENT; BIOASSAY-DIRECTED FRACTIONATION; TYPHIMURIUM
TESTER STRAINS; CHINESE-HAMSTER CELLS; AMES TEST; DRINKING-WATER; RODENT
CARCINOGENICITY; NEUROSPORA-CRASSA; MICROSOME TEST; HUMAN BREAST
AB OBJECTIVES: According to the 2007 National Research Council report Toxicology for the Twenty-First Century, modern methods (e.g., "omics," in vitro assays, high-throughput testing, computational methods) will lead to the emergence of a new approach to toxicology. The Salmonella mammalian microsome mutagenicity assay has been central to the field of genetic toxicology since the 1970s. Here we document the paradigm shifts engendered by the assay, the validation and applications of the assay, and how the assay is a model for future in vitro toxicology assays.
DATA SOURCES: We searched PubMed, Scopus, and Web of Knowledge using key words relevant to the Salmonella assay and additional genotoxicity assays.
DATA EXTRACTION: We merged the citations, removing duplicates, and categorized the papers by year and topic.
DATA SYNTHESIS: The Salmonella assay led to two paradigm shifts: that some carcinogens were mutagens and that some environmental samples (e.g., air, water, soil, food, combustion emissions) were mutagenic. Although there are > 10,000 publications on the Salmonella assay, covering tens of thousands of agents, data on even more agents probably exist in unpublished form, largely as proprietary studies by industry. The Salmonella assay is a model for the development of 21st century in vitro toxicology assays in terms of the establishment of standard procedures, ability to test various agents, transferability across laboratories, validation and testing, and structure-activity analysis.
CONCLUSIONS: Similar to a stethoscope as a first-line, inexpensive tool in medicine, the Salmonella assay can serve a similar, indispensable role in the foreseeable future of 21st century toxicology.
C1 [Claxton, Larry D.; DeMarini, David M.] US EPA, Genet & Cellular Toxicol Branch, Integrated Syst Toxicol Div, Res Triangle Pk, NC 27711 USA.
[Umbuzeiro, Gisela de A.] Univ Estadual Campinas, Fac Tecnol, Lab Ecotoxicol Aquat & Limnol, Sao Paulo, Brazil.
RP DeMarini, DM (reprint author), US EPA, Genet & Cellular Toxicol Branch, Integrated Syst Toxicol Div, B105-03, Res Triangle Pk, NC 27711 USA.
EM demarini.david@epa.gov
RI Umbuzeiro, Gisela/H-4603-2011;
OI Umbuzeiro, Gisela/0000-0002-8623-5200; Claxton,
Larry/0000-0001-7455-1583
FU U.S. Environmental Protection Agency (EPA)
FX This research was supported by the U.S. Environmental Protection Agency
(EPA).
NR 177
TC 50
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U1 7
U2 39
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD NOV
PY 2010
VL 118
IS 11
BP 1515
EP 1522
DI 10.1289/ehp.1002336
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 674CR
UT WOS:000283711800020
PM 20682480
ER
PT J
AU Richardson, SD
DeMarini, DM
Kogevinas, M
Fernandez, P
Marco, E
Lourencetti, C
Balleste, C
Heederik, D
Meliefste, K
McKague, AB
Marcos, R
Font-Ribera, L
Grimalt, JO
Villanueva, CM
AF Richardson, Susan D.
DeMarini, David M.
Kogevinas, Manolis
Fernandez, Pilar
Marco, Esther
Lourencetti, Carolina
Balleste, Clara
Heederik, Dick
Meliefste, Kees
McKague, A. Bruce
Marcos, Ricard
Font-Ribera, Laia
Grimalt, Joan O.
Villanueva, Cristina M.
TI What's in the Pool? A Comprehensive Identification of Disinfection
By-products and Assessment of Mutagenicity of Chlorinated and Brominated
Swimming Pool Water
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE bromination; bromine; chlorination; chlorine; DBPs; disinfection
by-products; mutagenicity; swimming pools; Salmonella; water
ID GLUTATHIONE-S-TRANSFERASE; DRINKING-WATER; TRIHALOMETHANE
CONCENTRATIONS; SALMONELLA MUTAGENICITY; EXPOSURE; GENOTOXICITY;
BROMODICHLOROMETHANE; CHLORAMINES; CHLOROFORM; EXPRESSION
AB BACKGROUND: Swimming pool disinfectants and disinfection by-products (DBPs) have been linked to human health effects, including asthma and bladder cancer, but no studies have provided a comprehensive identification of DBPs in the water and related that to mutagenicity.
OBJECTIVES: We performed a comprehensive identification of DBPs and disinfectant species in waters from public swimming pools in Barcelona, Catalonia, Spain, that disinfect with either chlorine or bromine and we determined the mutagenicity of the waters to compare with the analytical results.
METHODS: We used gas chromatography/mass spectrometry (GC/MS) to measure trihalomethanes in water, GC with electron capture detection for air, low- and high-resolution GC/MS to comprehensively identify DBPs, photometry to measure disinfectant species (free chlorine, monochloroamine, dichloramine, and trichloramine) in the waters, and an ion chromatography method to measure trichloramine in air. We assessed mutagenicity with the Salmonella mutagenicity assay.
RESULTS: We identified > 100 DBPs, including many nitrogen-containing DBPs that were likely formed from nitrogen-containing precursors from human inputs, such as urine, sweat, and skin cells. Many DBPs were new and have not been reported previously in either swimming pool or drinking waters. Bromoform levels were greater in brominated than in chlorinated pool waters, but we also identified many brominated DBPs in the chlorinated waters. The pool waters were mutagenic at levels similar to that of drinking water (similar to 1,200 revertants/L-equivalents in strain TA100-S9 mix).
CONCLUSIONS: This study identified many new DBPs not identified previously in swimming pool or drinking water and found that swimming pool waters are as mutagenic as typical drinking waters.
C1 [Richardson, Susan D.] US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA.
[DeMarini, David M.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Kogevinas, Manolis; Font-Ribera, Laia; Villanueva, Cristina M.] Ctr Res Environm Epidemiol, Barcelona, Spain.
[Kogevinas, Manolis; Font-Ribera, Laia; Villanueva, Cristina M.] Hosp del Mar, Municipal Inst Med Res, Barcelona, Spain.
[Kogevinas, Manolis; Villanueva, Cristina M.] CIBER Epidemiol & Salud Publ, Barcelona, Spain.
[Kogevinas, Manolis] Univ Athens, Sch Med, GR-10679 Athens, Greece.
[Fernandez, Pilar; Marco, Esther; Lourencetti, Carolina; Balleste, Clara; Grimalt, Joan O.] Inst Environm Assessment & Water Res, Dept Environm Chem, Barcelona, Spain.
[Heederik, Dick; Meliefste, Kees] Univ Utrecht, Inst Risk Assessment Sci, Div Environm Epidemiol, Utrecht, Netherlands.
[McKague, A. Bruce] CanSyn Chem Corp, Toronto, ON, Canada.
[Marcos, Ricard] Univ Autonoma Barcelona, Dept Genet & Microbiol, Grp Mutagenesi, Bellaterra, Cerdanyola Vall, Spain.
RP Richardson, SD (reprint author), US EPA, Natl Exposure Res Lab, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM richardson.susan@epa.gov
RI Grimalt, Joan/E-2073-2011; Fernandez, Pilar/E-6182-2010; Villanueva,
Cristina/N-1942-2014; Kogevinas, Manolis/C-3918-2017;
OI Grimalt, Joan/0000-0002-7391-5768; Fernandez, Pilar/0000-0002-4535-5214;
Villanueva, Cristina/0000-0002-0783-1259; Font-Ribera,
Laia/0000-0001-8447-4905; Marcos, Ricard/0000-0001-7891-357X
FU U.S. Environmental Protection Agency (EPA); Plan Nacional
[SAF2005-07643-C03-01]; Fondo de Investigacion Sanitaria [CP06/00341];
Instituto de Salud Carlos III [CP06/00341, FI06/00651];
Santander-Central Hispano; Consejo Superior de Investigaciones
Cientificas
FX This research was supported by the U.S. Environmental Protection Agency
(EPA) intramural research program and Spanish grants
SAF2005-07643-C03-01 (Plan Nacional) and CP06/00341 (Fondo de
Investigacion Sanitaria). C.M.V. and L.F.-R. have, respectively, a
contract and a predoctoral fellowship by the Instituto de Salud Carlos
III (CP06/00341, FI06/00651). C. L. acknowledges a grant from the
Agreement between Santander-Central Hispano and Consejo Superior de
Investigaciones Cientificas.
NR 54
TC 105
Z9 107
U1 13
U2 133
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD NOV
PY 2010
VL 118
IS 11
BP 1523
EP 1530
DI 10.1289/ehp.1001965
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 674CR
UT WOS:000283711800021
PM 20833605
ER
PT J
AU Kogevinas, M
Villanueva, CM
Font-Ribera, L
Liviac, D
Bustamante, M
Espinoza, F
Nieuwenhuijsen, MJ
Espinosa, A
Fernandez, P
DeMarini, DM
Grimalt, JO
Grummt, T
Marcos, R
AF Kogevinas, Manolis
Villanueva, Cristina M.
Font-Ribera, Laia
Liviac, Danae
Bustamante, Mariona
Espinoza, Felicidad
Nieuwenhuijsen, Mark J.
Espinosa, Aina
Fernandez, Pilar
DeMarini, David M.
Grimalt, Joan O.
Grummt, Tamara
Marcos, Ricard
TI Genotoxic Effects in Swimmers Exposed to Disinfection By-products in
Indoor Swimming Pools
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE cancer; chlorination; disinfection by-products; genetics; genotoxicity;
mutagenicity; swimming pools; water
ID BROMODICHLOROMETHANE METABOLISM; GENETIC POLYMORPHISMS; DRINKING-WATER;
COMET ASSAY; HUMAN LIVER; MICRONUCLEI; BLOOD; SALMONELLA; CHLOROFORM;
CELLS
AB BACKGROUND: Exposure to disinfection by-products (DBPs) in drinking water has been associated with cancer risk. A recent study (Villanueva et al. 2007; Am J Epidemiol 165:148-156) found an increased bladder cancer risk among subjects attending swimming pools relative to those not attending.
OBJECTIVES: We evaluated adults who swam in chlorinated pools to determine whether exposure to DBPs in pool water is associated with biomarkers of genotoxicity.
METHODS: We collected blood, urine, and exhaled air samples from 49 non-smoking adult volunteers before and after they swam for 40 min in an indoor chlorinated pool. We estimated associations between the concentrations of four trihalomethanes (THMs) in exhaled breath and changes in micronuclei (MN) and DNA damage (comet assay) in peripheral blood lymphocytes before and 1 hr after swimming; urine mutagenicity (Ames assay) before and 2 hr after swimming; and MN in exfoliated urothelial cells before and 2 weeks after swimming. We also estimated associations and interactions with polymorphisms in genes related to DNA repair or to DBP metabolism.
RESULTS: After swimming, the total concentration of the four THMs in exhaled breath was seven times higher than before swimming. The change in the frequency of micronucleated lymphocytes after swimming increased in association with higher exhaled concentrations of the brominated THMs (p = 0.03 for bromodichloromethane, p = 0.05 for chlorodibromomethane, p = 0.01 for bromoform) but not chloroform. Swimming was not associated with DNA damage detectable by the comet assay. Urine mutagenicity increased significantly after swimming, in association with the higher concentration of exhaled bromoform (p = 0.004). We found no significant associations with changes in micronucleated urothelial cells.
CONCLUSIONS: Our findings support potential genotoxic effects of exposure to DBPs from swimming pools. The positive health effects gained by swimming could be increased by reducing the potential health risks of pool water.
C1 [Kogevinas, Manolis; Villanueva, Cristina M.; Font-Ribera, Laia; Bustamante, Mariona; Nieuwenhuijsen, Mark J.; Espinosa, Aina] Ctr Res Environm Epidemiol, Barcelona 08003, Spain.
[Kogevinas, Manolis; Villanueva, Cristina M.; Font-Ribera, Laia; Nieuwenhuijsen, Mark J.; Espinosa, Aina] Hosp del Mar, Municipal Inst Med Res, Barcelona, Spain.
[Kogevinas, Manolis; Villanueva, Cristina M.; Font-Ribera, Laia; Bustamante, Mariona; Nieuwenhuijsen, Mark J.; Espinosa, Aina; Marcos, Ricard] CIBER Epidemiol & Salud Publ, Barcelona, Spain.
[Liviac, Danae; Espinoza, Felicidad; Marcos, Ricard] Univ Autonoma Barcelona, Dept Genet & Microbiol, Grp Mutagenesi, Bellaterra, Cerdanyola Vall, Spain.
[Bustamante, Mariona] Ctr Genom Regulat, Barcelona, Spain.
[Fernandez, Pilar; Grimalt, Joan O.] Inst Environm Assessment & Water Res, Barcelona, Spain.
[DeMarini, David M.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Grummt, Tamara] Fed Environm Agcy, Bad Elster, Germany.
[Kogevinas, Manolis] Natl Sch Publ Hlth, Athens, Greece.
RP Kogevinas, M (reprint author), Ctr Res Environm Epidemiol, 88 Dr Aiguader Rd, Barcelona 08003, Spain.
EM kogevinas@creal.cat
RI Grimalt, Joan/E-2073-2011; Fernandez, Pilar/E-6182-2010; Villanueva,
Cristina/N-1942-2014; Bustamante, Mariona/M-7277-2015; Nieuwenhuijsen,
Mark/C-3914-2017; Kogevinas, Manolis/C-3918-2017;
OI Marcos, Ricard/0000-0001-7891-357X; Grimalt, Joan/0000-0002-7391-5768;
Fernandez, Pilar/0000-0002-4535-5214; Villanueva,
Cristina/0000-0002-0783-1259; Bustamante, Mariona/0000-0003-0127-2860;
Nieuwenhuijsen, Mark/0000-0001-9461-7981; Font-Ribera,
Laia/0000-0001-8447-4905
FU Plan Nacional [SAF2005-07643-C03-01/02/03]; Spanish Health Ministry [FIS
CP06/00341]; Instituto de Salud Carlos III [CP06/00341]; Spanish Health
Ministry; Universitat Autonoma de Barcelona
FX This research was supported by Plan Nacional grant
SAF2005-07643-C03-01/02/03 and by Spanish Health Ministry grant FIS
CP06/00341. C.M.V. was supported by the Instituto de Salud Carlos III
(CP06/00341); L.F.-R. was supported by a predoctoral fellowship
(FI06/00651) from the Spanish Health Ministry; and D.L., by postgraduate
fellowship (PIF409-009) from the Universitat Autonoma de Barcelona.
NR 48
TC 62
Z9 65
U1 2
U2 40
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD NOV
PY 2010
VL 118
IS 11
BP 1531
EP 1537
DI 10.1289/ehp.1001959
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 674CR
UT WOS:000283711800022
PM 20833606
ER
PT J
AU Schoeny, R
AF Schoeny, Rita
TI Disinfection By-products: A Question of Balance
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Editorial Material
ID DRINKING-WATER
C1 US EPA, Off Water, Washington, DC 20460 USA.
RP Schoeny, R (reprint author), US EPA, Off Water, Washington, DC 20460 USA.
EM schoeny.rita@epa.gov
NR 7
TC 3
Z9 3
U1 0
U2 5
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD NOV
PY 2010
VL 118
IS 11
BP A466
EP A467
DI 10.1289/ehp.1003053
PG 2
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 674CR
UT WOS:000283711800001
PM 21465736
ER
PT J
AU Marfil-Vega, R
Suidan, MT
Mills, MA
AF Marfil-Vega, Ruth
Suidan, Makram T.
Mills, Marc A.
TI Abiotic transformation of estrogens in synthetic municipal wastewater:
An alternative for treatment?
SO ENVIRONMENTAL POLLUTION
LA English
DT Article
DE Estrogens; Catalytic reactions; Adsorption; Fate; Wastewater; Sludge
ID ENDOCRINE DISRUPTING COMPOUNDS; REMOVAL; OXIDATION; HORMONES;
17-ALPHA-ETHYNYLESTRADIOL; BIODEGRADATION; MANGANESE; SORPTION; FATE;
17-BETA-ESTRADIOL
AB The abiotic transformation of estrogens, including estrone (E1), estradiol (E2), estriol (E3) and ethinylestradiol (EE2), in the presence of model vegetable matter was confirmed in this study. Batch experiments were performed to model the catalytic conversion of E1, E2, E3 and EE2 in synthetic wastewater Greater than 80% reduction in the parent compounds was achieved for each target chemical after 72 h with the remaining concentration distributed between aqueous and solid phases as follows. 13% and 7% for E1, 10% and 2% for E2, 6% and 2% for E3, and 8% and 3% for EE2, respectively Testosterone, androstenedione and progesterone were also monitored in this study, and their concentrations were found to be in agreement with initially spiked amount. Data collected under laboratory conditions provided the basis for implementing new abiotic wastewater treatment technologies that use inexpensive materials (C) 2010 Elsevier Ltd All rights reserved.
C1 [Marfil-Vega, Ruth; Suidan, Makram T.] Univ Cincinnati, Sch Energy Environm Biol & Med Engn, Cincinnati, OH 45221 USA.
[Mills, Marc A.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Suidan, MT (reprint author), Univ Cincinnati, Sch Energy Environm Biol & Med Engn, Cincinnati, OH 45221 USA.
RI Mills, Marc/C-3449-2017
OI Mills, Marc/0000-0002-0169-3086
NR 27
TC 7
Z9 7
U1 3
U2 26
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0269-7491
J9 ENVIRON POLLUT
JI Environ. Pollut.
PD NOV
PY 2010
VL 158
IS 11
BP 3372
EP 3377
DI 10.1016/j.envpol.2010.07042
PG 6
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 659JQ
UT WOS:000282563200003
PM 20817369
ER
PT J
AU Hou, WC
Kong, LJ
Wepasnick, KA
Zepp, RG
Fairbrother, DH
Jafvert, CT
AF Hou, Wen-Che
Kong, Lingjun
Wepasnick, Kevin A.
Zepp, Richard G.
Fairbrother, D. Howard
Jafvert, Chad T.
TI Photochemistry of Aqueous C-60 Clusters: Wavelength Dependency and
Product Characterization
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID WATER-SOLUBLE FULLERENES; CARBON; TRANSFORMATION; NANOMATERIALS;
CHEMISTRY; FORM
AB To construct accurate risk assessment models for engineered nanomaterials, there is urgent need for information on the reactivity (or conversely, persistence) and transformation pathways of these materials in the natural environment. As an important step toward addressing this issue, we have characterized the products formed when aqueous C-60 clusters (nC(60)) are exposed to natural sunlight and also have assessed the wavelengths primarily responsible for phototransformation. Long-wavelength light (lambda >= 400 nm) isolated from sunlight, was shown to be important in both the phototransformation of nC(60) and in the production of O-1(2). The significance of visible light in mediating the phototransformation of nC(60) was supported by additional experiments with monochromatic light in which the apparent quantum yield at 436 nm (Phi(436) (nm) = (2.08 +/- 0.08) x 10(-5)) was comparable to that at 366 nm (Phi(356) (nm) = (2.02 +/- 0.07) x 10(-5)). LDI-TOF mass spectrometry indicated that most of the photoproducts formed after 947 h of irradiation in natural sunlight retain a 60 atom carbon structure. A combination of C-13 NMR analysis of C-13-enriched nC(60), X-ray photoelectron spectroscopy and FTIR indicated that photoproducts have olefinic carbon atoms as well as a variety of oxygen-containing functional groups, including vinyl ether and carbonyl or carboxyl groups, whose presence destroys the native pi-electron system of C-60. Thus, the photoreactivity of nC(60) in sunlight leads to the formation of water-soluble C-60 derivatives.
C1 [Hou, Wen-Che; Jafvert, Chad T.] Purdue Univ, Sch Civil Engn, W Lafayette, IN 47907 USA.
[Kong, Lingjun] Natl Res Council Associate, Natl Exposure Res Lab, Ecosyst Res Div, Athens, GA 30605 USA.
[Wepasnick, Kevin A.; Fairbrother, D. Howard] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA.
[Kong, Lingjun; Zepp, Richard G.] US EPA, Athens, GA 30605 USA.
RP Hou, WC (reprint author), Purdue Univ, Sch Civil Engn, W Lafayette, IN 47907 USA.
EM whou4@asu.edu; jafvert@ecn.purdue.edu
RI Hou, Wen-Che/F-5736-2011; Jafvert, Chad/D-9551-2013
OI Hou, Wen-Che/0000-0001-9884-2932;
FU United States Environmental Protection Agency (U.S. EPA) [RD 83334001];
National Science Foundation [BES0731147]; Environmental Protection
Agency [RD-83385701-0]; Institute for Nanobiotechnology at Johns Hopkins
University
FX Financial support was provided by the United States Environmental
Protection Agency (U.S. EPA) under Award RD 83334001 of the STAR grant
program. We thank Dr. Changhe Xiao for technical assistance; Dr. Karl
Wood at the campus-wide Mass Spectrometry Center (CWMSC) of Purdue
University for mass spectrometric analysis and discussion; Ms. Debra
Sherman at the Life Science Microscopy Facility of Purdue University for
TEM imaging; Prof. Hugh Hillhouse and Dr. Qijie Coo at the School of
Chemical Engineering of Purdue University for use of the FTIR
spectrophotometer and help in recording spectra; Dr. Zhengwei Pan and
Mr. Yen-Jun Chuang at University of Georgia for transmittance/absorbance
measurements using the UV-visible spectrometer equipped with an
integrating sphere attachment; Drs. Quincy Teng and Wenlin Huang at the
U.S. EPA, National Exposure Research Laboratory, Athens, Georgia for
13C NMR analysis and discussion. D.H.F. and K.W. gratefully
acknowledge partial financial support from the National Science
Foundation (Grant No. BES0731147), the Environmental Protection Agency
(Grant No. RD-83385701-0) and the Institute for Nanobiotechnology at
Johns Hopkins University. This paper has been reviewed in accordance
with the U.S. EPA's peer and administrative review policies and approved
for publication. Mention of trade names or commercial products does not
constitute an endorsement or recommendation for use by the U.S. EPA.
NR 24
TC 38
Z9 39
U1 0
U2 42
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD NOV 1
PY 2010
VL 44
IS 21
BP 8121
EP 8127
DI 10.1021/es101230q
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 671EV
UT WOS:000283484000026
PM 20939530
ER
PT J
AU Hoffman, JC
Peterson, GS
Cotter, AM
Kelly, JR
AF Hoffman, Joel C.
Peterson, Gregory S.
Cotter, Anne M.
Kelly, John R.
TI Using Stable Isotope Mixing in a Great Lakes Coastal Tributary to
Determine Food Web Linkages in Young Fishes
SO ESTUARIES AND COASTS
LA English
DT Article
DE delta(13)C; delta(15)N; Trophic; Lake Superior; St. Louis River
ID YORK RIVER ESTUARY; ORGANIC-MATTER; CARBON-ISOTOPE; AMAZON RIVER; WATER;
WETLANDS; ZOOPLANKTON; ENRICHMENT; ECOSYSTEMS; DELTA-C-13
AB We characterized stable isotope mixing along a river-Great Lake transition zone in the St. Louis River, an important fish nursery in western Lake Superior, and used it to identify food web linkages supporting young fish production. We observed a broad, spatial pattern in the carbon stable isotope ratio (delta(13)C); downriver enrichment in particulate organic carbon and aquatic vegetation delta(13)C, as well as pelagic, benthic and littoral invertebrate delta(13)C, reflected isotope mixing along the river-lake transition zone. Fishes with similarly enriched delta(13)C were used to identify benthopelagic and littoral trophic pathways. River and Lake Superior organic matter (OM) sources contributed to both pathways. Differences between the delta(13)C in fishes and invertebrate prey revealed that fish production was supported at multiple spatial scales. The result was that the food web specific to any location along the transition zone incorporated multiple OM sources from across the watershed.
C1 [Hoffman, Joel C.; Peterson, Gregory S.; Cotter, Anne M.; Kelly, John R.] US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, Duluth, MN 55804 USA.
RP Hoffman, JC (reprint author), US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, 6201 Congdon Blvd, Duluth, MN 55804 USA.
EM Hoffman.Joel@epa.gov
NR 49
TC 22
Z9 22
U1 5
U2 19
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1559-2723
J9 ESTUAR COAST
JI Estuaries Coasts
PD NOV
PY 2010
VL 33
IS 6
BP 1391
EP 1405
DI 10.1007/s12237-010-9295-0
PG 15
WC Environmental Sciences; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA 658SZ
UT WOS:000282511000011
ER
PT J
AU McKinney, RA
Oczkowski, AJ
Prezioso, J
Hyde, KJW
AF McKinney, R. A.
Oczkowski, A. J.
Prezioso, J.
Hyde, K. J. W.
TI Spatial variability of nitrogen isotope ratios of particulate material
from Northwest Atlantic continental shelf waters
SO ESTUARINE COASTAL AND SHELF SCIENCE
LA English
DT Article
DE nitrogen; stable isotope; continental shelf; particulate material;
estuary; chlorophyll-a
ID STABLE-ISOTOPE; COASTAL WATERS; ATMOSPHERIC NITROGEN; ORGANIC-MATTER;
UNITED-STATES; FOOD-WEB; NITRATE; OCEAN; PHYTOPLANKTON; ECOSYSTEMS
AB Human encroachment on the coastal zone has led to concern about the impact of anthropogenic nitrogen (N) on estuarine and continental shelf waters. Western North Atlantic watershed budgets suggest that the export of human-derived N from estuaries to shelf waters off the east coast of the US may be significant: however, models based on water inputs and estimates of upwelling of deepwater nutrients to surface waters of the mid-Atlantic bight indicate that estuarine N may be a relatively minor component of the overall shelf N budget. Stable N isotope ratios could provide a means to assess the relative input of anthropogenic N to shelf waters, particularly since dissolved N from human sources has elevated delta(15)N values (range: 7-30 parts per thousand). We collected particulate material from surface shelf waters off the US east coast from 2000 to 2005 at near-shore sample sites proximal to the mouth of six estuaries and corresponding sites farther offshore. Near-shore (mean 33.7 km from estuary mouth) delta(15)N values ranged from 5.5 to 7.7 parts per thousand, Offshore values (mean 92.4 km from estuary mouth) were consistently lower than near-shore sites (average 4.7 +/- 1.0 parts per thousand versus 6.8 +/- 1.1 parts per thousand)(,) suggesting different N sources to near and offshore stations. Near-shore regions are often more productive, as mean monthly chlorophyll-a concentrations from the sea-viewing wide field-of-view sensor (SeaWiFS) were significantly higher at near-shore sites near the mouth of three of the six estuaries. A mass balance using a concentration-dependent mixing model with chlorophyll-a concentrations as a surrogate for dissolved inorganic nitrogen can account for all of the nitrogen at near-shore sites south of Cape Cod with estuarine nitrogen estimated to contribute 45-85% of the nitrogen to the near-shore surface particulate material. Our results support the hypothesis that estuarine nitrogen is influencing continental shelf ecosystems, and also provide preliminary evidence of the spatial extent of its influence on shelf waters in the mid-Atlantic bight. Published by Elsevier Ltd.
C1 [McKinney, R. A.; Oczkowski, A. J.] USA, US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab,Atlantic Eco, Narragansett, RI 02882 USA.
[Prezioso, J.; Hyde, K. J. W.] NOAA, Natl Marine Fisheries Serv, NE Fisheries Sci Ctr, Narragansett Lab, Narragansett, RI 02882 USA.
RP McKinney, RA (reprint author), USA, US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab,Atlantic Eco, 27 Tarzwell Dr, Narragansett, RI 02882 USA.
EM mckinney.rick@epa.gov
OI Oczkowski, Autumn/0000-0002-2421-0956
FU U.S. Environmental Protection Agency
FX We thank Joe Kane for assistance with sample collection and data
analysis. Also many thanks to John O'Reilly for providing chlorophyll-a
data and Teresa Ducas for help with data processing. We are grateful to
Scott Nixon, Richard Pruell and Mark Cantwell for their critical review
and helpful comments that greatly improved the manuscript. Mention of
trade names or commercial products does not constitute endorsement or
recommendation. Although the research described in this article has been
funded wholly by the U.S. Environmental Protection Agency, it has not
been subjected to Agency-level review. Therefore, it does not
necessarily reflect the views of the Agency. This is the Office of
Research and Development, National Health and Environmental Effects
Research Laboratory, Atlantic Ecology Division contribution number
AED-08-083.
NR 57
TC 9
Z9 9
U1 3
U2 16
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0272-7714
J9 ESTUAR COAST SHELF S
JI Estuar. Coast. Shelf Sci.
PD NOV 1
PY 2010
VL 89
IS 4
BP 287
EP 293
DI 10.1016/j.ecss.2010.08.004
PG 7
WC Marine & Freshwater Biology; Oceanography
SC Marine & Freshwater Biology; Oceanography
GA 664ZF
UT WOS:000283002100005
ER
PT J
AU Laughlin, SK
Herring, AH
Savitz, DA
Olshan, AF
Fielding, JR
Hartmann, KE
Baird, DD
AF Laughlin, Shannon K.
Herring, Amy H.
Savitz, David A.
Olshan, Andrew F.
Fielding, Julia R.
Hartmann, Katherine E.
Baird, Donna D.
TI Pregnancy-related fibroid reduction
SO FERTILITY AND STERILITY
LA English
DT Editorial Material
DE Leiomyoma; postpartum; pregnancy; ultrasound; uterine remodeling
ID UTERINE LEIOMYOMATA; REPRODUCTIVE FACTORS; WHITE WOMEN; GROWTH; RISK;
SIZE
AB We tested the hypothesis that the protective effect of parity on fibroids is due to direct pregnancy-related effects by following women from early pregnancy to postpartum period with ultrasound. Of 171 women with one initial fibroid, 36% had no identifiable fibroid at the time of postpartum ultrasound, and 79% of the remaining fibroids decreased in size. (Fertil Steril (R) 2010;94:2421-3. (C)2010 by American Society for Reproductive Medicine.)
C1 [Laughlin, Shannon K.; Baird, Donna D.] Natl Inst Environm Hlth Sci, Epidemiol Branch, NIH, Res Triangle Pk, NC USA.
[Laughlin, Shannon K.] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA.
Univ N Carolina, Dept Biostat, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA.
[Herring, Amy H.] Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC USA.
[Savitz, David A.; Olshan, Andrew F.] Mt Sinai Sch Med, Dis Prevent & Publ Hlth Inst, New York, NY USA.
[Fielding, Julia R.] Univ N Carolina, Dept Radiol, Chapel Hill, NC USA.
[Hartmann, Katherine E.] Vanderbilt Univ, Inst Med & Publ Hlth, Nashville, TN USA.
[Hartmann, Katherine E.] Vanderbilt Univ, Med Ctr, Dept Obstet & Gynecol, Nashville, TN 37232 USA.
RP Laughlin, SK (reprint author), Mayo Clin, Dept Obstet & Gynecol, 200 1st St SW, Rochester, MN 55905 USA.
EM laughlin.shannon@mayo.edu
RI Baird, Donna/D-5214-2017
OI Baird, Donna/0000-0002-5544-2653
FU Intramural NIH HHS; NICHD NIH HHS [R01 HD043883-04, HD049675, R01
HD043883, R01 HD049675, R24 HD050924]; NIEHS NIH HHS [P30 ES010126,
P30ES10126]
NR 19
TC 25
Z9 25
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0015-0282
J9 FERTIL STERIL
JI Fertil. Steril.
PD NOV
PY 2010
VL 94
IS 6
BP 2421
EP 2423
DI 10.1016/j.fertnstert.2010.03.035
PG 3
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA 670QC
UT WOS:000283441400112
PM 20451187
ER
PT J
AU Kaushal, SS
Likens, GE
Jaworski, NA
Pace, ML
Sides, AM
Seekell, D
Belt, KT
Secor, DH
Wingate, RL
AF Kaushal, Sujay S.
Likens, Gene E.
Jaworski, Norbert A.
Pace, Michael L.
Sides, Ashley M.
Seekell, David
Belt, Kenneth T.
Secor, David H.
Wingate, Rebecca L.
TI Rising stream and river temperatures in the United States
SO FRONTIERS IN ECOLOGY AND THE ENVIRONMENT
LA English
DT Article
ID LONG-TERM WATER; CLIMATE-CHANGE; LAND-USE; TRENDS; URBANIZATION; IMPACT
AB Water temperatures are increasing in many streams and rivers throughout the US. We analyzed historical records from 40 sites and found that 20 major streams and rivers have shown statistically significant, long-term warming. Annual mean water temperatures increased by 0.009-0.077 degrees C yr(-1), and rates of warming were most rapid in, but not confined to, urbanizing areas. Long-term increases in stream water temperatures were typically correlated with increases in air temperatures. If stream temperatures were to continue to increase at current rates, due to global warming and urbanization, this could have important effects on eutrophication, ecosystem processes such as biological productivity and stream metabolism, contaminant toxicity, and loss of aquatic biodiversity.
C1 [Kaushal, Sujay S.; Sides, Ashley M.; Secor, David H.; Wingate, Rebecca L.] Univ Maryland, Chesapeake Biol Lab, Ctr Environm Sci, Solomons, MD 20688 USA.
[Likens, Gene E.; Pace, Michael L.] Cary Inst Ecosyst Studies, Millbrook, NY USA.
[Jaworski, Norbert A.] US EPA, Sanford, FL USA.
[Seekell, David] Univ Vermont, Rubenstein Sch Environm & Nat Resources, Burlington, VT USA.
[Belt, Kenneth T.] US Forest Serv, USDA, No Res Stn, Baltimore, MD USA.
[Belt, Kenneth T.] Univ Maryland Baltimore Cty, Baltimore, MD 21228 USA.
RP Kaushal, SS (reprint author), Univ Maryland, Chesapeake Biol Lab, Ctr Environm Sci, Solomons, MD 20688 USA.
EM kaushal@cbl.umces.edu
RI Secor, D/D-4367-2012; Kaushal, Sujay/G-1062-2013;
OI Secor, D/0000-0001-6007-4827; Kaushal, Sujay/0000-0003-0834-9189; Pace,
Michael/0000-0001-5945-6131
FU NSF [DBI 0640300, DEB 0454001]; Maryland Sea Grant [SA7528085-U]; NSF
LTER [DEB-9714835]
FX M Palmer provided helpful comments. Research was supported by NSF DBI
0640300, Maryland Sea Grant SA7528085-U, NSF LTER DEB-9714835, NSF DEB
0454001. Data were provided by: J Cole and MLP (Hudson River), GEL (NSF
supported LTER and LTREB at HBEF), NAJ (Potomac River), KTB (BES LTER),
W Stack (Gun Powder and Patapsco River), DHS and RLW (Patuxent River),
and all additional sites (USGS). D Buso assisted with and managed field
measurements at Hubbard Brook Experimental Forest. R Utz provided
watershed information. This paper is scientific contribution number 4338
from the University of Maryland Center for Environmental Science.
NR 21
TC 181
Z9 185
U1 5
U2 95
PU ECOLOGICAL SOC AMER
PI WASHINGTON
PA 1990 M STREET NW, STE 700, WASHINGTON, DC 20036 USA
SN 1540-9295
J9 FRONT ECOL ENVIRON
JI Front. Ecol. Environ.
PD NOV
PY 2010
VL 8
IS 9
BP 461
EP 466
DI 10.1890/090037
PG 6
WC Ecology; Environmental Sciences
SC Environmental Sciences & Ecology
GA 679KG
UT WOS:000284159700016
ER
PT J
AU Van Emon, JM
AF Van Emon, Jeanette M.
TI Bioanalytical Methods for Food Contaminant Analysis
SO JOURNAL OF AOAC INTERNATIONAL
LA English
DT Article
ID LINKED-IMMUNOSORBENT-ASSAY; INDIRECT COMPETITIVE IMMUNOASSAY;
PRESSURIZED LIQUID EXTRACTION; MASS-SPECTROMETRY; BIOSENSOR IMMUNOASSAY;
ENVIRONMENTAL-SAMPLES; GOLD NANOPARTICLES; PESTICIDE-RESIDUES; QUANTUM
DOTS; DIET SAMPLES
AB Foods are complex mixtures of lipids, carbohydrates, proteins, vitamins, organic compounds, and other naturally occurring substances. Sometimes added to this mixture are residues of pesticides, veterinary and human drugs, microbial toxins, preservatives, contaminants from food processing and packaging, and other residues. This milieu of compounds can pose difficulties in the analysis of food contaminants. There is an expanding need for rapid and cost-effective residue methods for difficult food matrixes to safeguard our food supply. Bioanalytical methods are established for many food contaminants such as mycotoxins and are the method of choice for many food allergens. Bioanalytical methods are often more cost-effective and sensitive than instrumental procedures. Recent developments in bioanalytical methods may provide more applications for their use in food analysis.
C1 US EPA, Natl Exposure Res Lab, Methods Dev & Applicat Branch, Las Vegas, NV 89193 USA.
RP Van Emon, JM (reprint author), US EPA, Natl Exposure Res Lab, Methods Dev & Applicat Branch, POB 93478, Las Vegas, NV 89193 USA.
EM vanemon.jeanette@epa.gov
NR 103
TC 11
Z9 11
U1 2
U2 12
PU AOAC INT
PI GAITHERSBURG
PA 481 N FREDRICK AVE, STE 500, GAITHERSBURG, MD 20877-2504 USA
SN 1060-3271
EI 1944-7922
J9 J AOAC INT
JI J. AOAC Int.
PD NOV-DEC
PY 2010
VL 93
IS 6
BP 1681
EP 1691
PG 11
WC Chemistry, Analytical; Food Science & Technology
SC Chemistry; Food Science & Technology
GA 705RW
UT WOS:000286156600002
PM 21313795
ER
PT J
AU Mirghani, BY
Tryby, ME
Ranjithan, RS
Karonis, NT
Mahinthakumar, KG
AF Mirghani, Baha Y.
Tryby, Michael E.
Ranjithan, Ranji S.
Karonis, Nicholas T.
Mahinthakumar, Kumar G.
TI Grid-Enabled Simulation-Optimization Framework for Environmental
Characterization
SO JOURNAL OF COMPUTING IN CIVIL ENGINEERING
LA English
DT Article
DE Simulation models
ID GROUNDWATER INVERSE PROBLEMS; IMPLEMENTATION; ALGORITHM
AB Many engineering and environmental problems that involve the determination of unknown system characteristics from observation data can be categorized as inverse problems. A common approach undertaken to solve such problems is the simulation-optimization approach where simulation models are coupled with optimization or search methods. Simulation-optimization approaches, particularly in environmental characterization involving natural systems, are computationally expensive due to the complex three-dimensional simulation models required to represent these systems and the large number of such simulations involved. Emerging grid computing environments (e.g., TeraGrid) show promise for improving the computational tractability of these approaches. However, harnessing grid resources for most computational applications is a nontrivial problem due to the complex hierarchy of heterogeneous and geographically distributed resources involved in a grid. This paper reports and discusses the development and evaluation of a grid-enabled simulation-optimization framework for solving environmental characterization problems. The framework is designed in a modular fashion that simplifies coupling with simulation model executables, allowing application of simulation-optimization approaches across problem domains. The framework architecture utilizes standard communications protocols and the message passing interface with an application programming interface to establish a connection between a centralized search application and simulation models running on TeraGrid resources. Sets of performance and scalability results for solving a groundwater source history reconstruction (SHR) problem are presented. The results show that for a given set of resources, parameters controlling the granularity at various levels of parallelism play an important role in the overall parallel performance. A production run for solving the SHR problem using three geographically distributed grid resources indicates that even in a cross-site grid environment a factor of 90 speedup is possible using 140 computer processors.
C1 [Ranjithan, Ranji S.; Mahinthakumar, Kumar G.] N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA.
[Mirghani, Baha Y.] Brown & Caldwell, Union Pk Ctr 6955, Midvale, UT 84047 USA.
[Tryby, Michael E.] US EPA, Ecosyst Res Div, Athens, GA 30605 USA.
[Karonis, Nicholas T.] No Illinois Univ, Dept Comp Sci, De Kalb, IL 60115 USA.
[Karonis, Nicholas T.] Argonne Natl Lab, Div Math & Comp Sci, Argonne, IL 60439 USA.
RP Mahinthakumar, KG (reprint author), N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA.
EM bahamirghani@gmail.com; trybymichael@epa.gov; ranji@ncsu.edu;
karonis@niu.edu; gmkumar@ncsu.edu
FU National Science Foundation (NSF) [BES-0238623, BES-0312841,
ANI-0222983, ANI-0330664, SCI-0503697]
FX This work was supported in part by the National Science Foundation (NSF)
under Grant Nos. BES-0238623, BES-0312841, ANI-0222983, ANI-0330664, and
SCI-0503697. Any opinions, findings, and conclusions or recommendations
expressed in this material are those of the writers and do not
necessarily reflect the views of the National Science Foundation. The
writers would also like to acknowledge NSF TeraGrid sites at National
Center for Supercomputing Applications, San Diego Supercomputing Center,
and Argonne National Laboratory for providing the resources needed for
this paper.
NR 31
TC 1
Z9 1
U1 0
U2 4
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0887-3801
EI 1943-5487
J9 J COMPUT CIVIL ENG
JI J. Comput. Civil. Eng.
PD NOV-DEC
PY 2010
VL 24
IS 6
BP 488
EP 498
DI 10.1061/(ASCE)CP.1943-5487.0000052
PG 11
WC Computer Science, Interdisciplinary Applications; Engineering, Civil
SC Computer Science; Engineering
GA 667LR
UT WOS:000283195300004
ER
PT J
AU Walker, MP
DiAugustine, RP
Zeringue, E
Bunger, MK
Schmitt, M
Archer, TK
Richards, RG
AF Walker, Michael P.
DiAugustine, Richard P.
Zeringue, Ernest
Bunger, Maureen K.
Schmitt, Martina
Archer, Trevor K.
Richards, R. Gregg
TI An IGF1/insulin receptor substrate-1 pathway stimulates a mitotic kinase
(cdk1) in the uterine epithelium during the proliferative response to
estradiol
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID CYCLIN-DEPENDENT KINASES; FACTOR-I RECEPTOR; CELL-CYCLE; GROWTH-FACTOR;
HISTONE H1; M-PHASE; TARGETED DISRUPTION; SIGNAL-TRANSDUCTION; NULL
MUTATION; RAT UTERUS
AB Estrogens are potent mitogens for some target organs, such as the uterus, and cancers that develop in this organ might be linked to the proliferative action of these hormones. However, the mechanism by which estrogens influence the cell cycle machinery is not known. We found that a null mutation for the insulin receptor substrate (IRS)-1, a docking protein that is important for IGF1 signaling, compromised hormone-induced mitosis in the uterine epithelium; BrdU incorporation was not affected. This selective effect on mitosis was associated with a reduction in uterine cyclin B-associated kinase activity; cyclin A-associated kinase activity was not changed. The null mutation also reduced the extent of hormone-induced phosphorylation of endogenous uterine histone H1, as determined with phospho-specific antiserum. Uterine epithelial cyclin dependent kinase (cdk)1 was induced in response to hormone, but the level of the kinase protein, as determined by immunoblotting, was noticeably less in the irs1 null mutant than that in the wild-type (WT) mouse, especially around the time of peak mitosis (24 h). Since IRS-1 binds/activates phosphatidylinositol 3-kinase (PI3K), the absence of this docking protein could impair signaling of a known pathway downstream of AKT that stimulates translation of cell cycle components. Indeed, we found that phosphorylation of uterine AKT (Ser473) in irs1 null mutants was less than that in WTs following treatment. Based on earlier studies, it is also possible that an IGF1/IRS-1/PI3K/AKT pathway regulates posttranslational changes in cdk1. This model may provide insights as to how a growth factor pathway can mediate hormone action on cell proliferation. Journal of Endocrinology (2010) 207, 225-235
C1 [Walker, Michael P.; DiAugustine, Richard P.; Zeringue, Ernest; Bunger, Maureen K.; Schmitt, Martina; Archer, Trevor K.; Richards, R. Gregg] Natl Inst Environm Hlth Sci, Mol Carcinogenesis Lab, NIH, Res Triangle Pk, NC 27709 USA.
RP Archer, TK (reprint author), Natl Inst Environm Hlth Sci, Mol Carcinogenesis Lab, NIH, Mail Drop D4-01,POB 12233, Res Triangle Pk, NC 27709 USA.
EM archer1@niehs.nih.gov
FU National Institute of Environmental Health Sciences, NIH [Z01
ES071006-09]
FX This research was supported by the Intramural Research Program of the
National Institute of Environmental Health Sciences, NIH; project number
Z01 ES071006-09.
NR 56
TC 8
Z9 8
U1 1
U2 1
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
ENGLAND
SN 0022-0795
J9 J ENDOCRINOL
JI J. Endocrinol.
PD NOV
PY 2010
VL 207
IS 2
BP 225
EP 235
DI 10.1677/JOE-10-0102
PG 11
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 662RH
UT WOS:000282828700011
PM 20798132
ER
PT J
AU Grant, LD
AF Grant, Lester D.
TI Getting the lead out: important exposure science contributions
SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
LA English
DT Editorial Material
AB Lead is a highly useful metal, but it has long been feared because of the risks it poses to human health. The characterization of human lead-exposure pathways and internal lead burdens is an important exposure science advance that has contributed to an impressive public health success story that is not yet finished.
C1 [Grant, Lester D.] US EPA, Natl Ctr Environm Assessment, RTP Div, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
EM ldgrant27517@yahoo.com
NR 5
TC 1
Z9 1
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1559-0631
J9 J EXPO SCI ENV EPID
JI J. Expo. Sci. Environ. Epidemiol.
PD NOV-DEC
PY 2010
VL 20
IS 7
BP 577
EP 578
DI 10.1038/jes.2010.47
PG 2
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 667CO
UT WOS:000283170400003
PM 20959833
ER
PT J
AU Anderson, CR
Sapiano, MRP
Prasad, MBK
Long, W
Tango, PJ
Brown, CW
Murtugudde, R
AF Anderson, Clarissa R.
Sapiano, Mathew R. P.
Prasad, M. Bala Krishna
Long, Wen
Tango, Peter J.
Brown, Christopher W.
Murtugudde, Raghu
TI Predicting potentially toxigenic Pseudo-nitzschia blooms in the
Chesapeake Bay
SO JOURNAL OF MARINE SYSTEMS
LA English
DT Article
DE Algal blooms; Domoic acid; Amnesic shellfish poisoning; Diatoms;
Prediction; Regression analysis; Chesapeake Bay
ID HARMFUL ALGAL BLOOMS; GULF-OF-MEXICO; DOMOIC ACID PRODUCTION;
PHYSICAL-BIOLOGICAL MODEL; NORTH PACIFIC-OCEAN; KARENIA-BREVIS;
AUSTRALIS BACILLARIOPHYCEAE; ENVIRONMENTAL-CONDITIONS; SILICATE
LIMITATION; ECOSYSTEM MODEL
AB Harmful algal blooms are now recognized as a significant threat to the Chesapeake Bay as they can severely compromise the economic viability of important recreational and commercial fisheries in the largest estuary of the United States This study describes the development of empirical models for the potentially domoic acid producing Pseudo-nitzschia species complex present in the Bay developed from a 22-year time series of cell abundance and concurrent measurements of hydrographic and chemical properties Using a logistic Generalized Linear Model (GLM) approach model parameters and performance were compared over a range of Pseudo nitzschia bloom thresholds relevant to toxin production by different species Small threshold blooms (>= 10cells mL(-1)) are explained by time of year location and variability in surface values of phosphate temperature nitrate plus nitrite and freshwater discharge Medium (100 cells mL(-1)) to large-threshold (1000 cells mL(-1)) blooms are further explained by salinity silicic acid dissolved organic carbon and light attenuation (Secchi) depth These predictors are similar to other models for Pseudo nitzschia blooms on the west coast suggesting commonalities across ecosystems Hindcasts of bloom probabilities at a 19% bloom prediction point yield a Heidke Skill Score of similar to 53% a Probability of Detection similar to 75% a False Alarm Ratio of similar to 52% and a Probability of False Detection similar to 9% The implication of possible future changes in Baywide nutrient stoichiometry on Pseudo-nitzschia blooms is discussed (C) 2010 Elsevier BV All rights reserved
C1 [Anderson, Clarissa R.] Univ Calif Santa Cruz, Ocean Sci Dept, Santa Cruz, CA 95064 USA.
[Anderson, Clarissa R.] Univ S Carolina, Dept Earth & Ocean Sci, Columbia, SC 29208 USA.
[Sapiano, Mathew R. P.] Colorado State Univ, Dept Atmospher Sci, Ft Collins, CO 80523 USA.
[Sapiano, Mathew R. P.] Univ Maryland, ESSIC, CICS, College Pk, MD 20742 USA.
[Long, Wen] Univ Maryland, Ctr Environm Sci, Horn Point Lab, Cambridge, MD 21613 USA.
[Tango, Peter J.] US Environm Protect Agcy, US Geol Survey, Chesapeake Bay Program Off, Annapolis, MD 21403 USA.
[Brown, Christopher W.] Natl Ocean & Atmospher Adm, CICS, College Pk, MD 20740 USA.
RP Anderson, CR (reprint author), Univ Calif Santa Cruz, Ocean Sci Dept, 1156 High St, Santa Cruz, CA 95064 USA.
RI Brown, Christopher/B-8213-2008
OI Brown, Christopher/0000-0002-9905-6391
FU National Research Council; NOAA National Environmental Satellite Data
and Information Service (NESDIS)
FX This study was funded by a National Research Council postdoctoral
fellowship to C R.A. sponsored by the NOAA National Environmental
Satellite Data and Information Service (NESDIS) with additional support
from NOAA MERHAB Award (PI CW B) and the Chesapeake Bay Forecasting
System project (PI It M) The authors gratefully acknowledge the Maryland
Department of Natural Resources and USEPA Chesapeake Bay Program for
contributing monitoring data and we are especially appreciative of the
technical assistance provided by J Johnson B Cole M Naylor W Butler B
Wind M Baith and J Beauchamps J lane D McGillicuddy and several
anonymous reviewers provided comments which greatly improved the paper
We give special thanks to A. Thessen for her innovative work on
Pseudo-nitzschia ecophysiology in the Chesapeake Bay and for significant
input to this manuscript
NR 108
TC 27
Z9 28
U1 8
U2 35
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0924-7963
J9 J MARINE SYST
JI J. Mar. Syst.
PD NOV
PY 2010
VL 83
IS 3-4
SI SI
BP 127
EP 140
DI 10.1016/j.jmarsys.2010.04.003
PG 14
WC Geosciences, Multidisciplinary; Marine & Freshwater Biology;
Oceanography
SC Geology; Marine & Freshwater Biology; Oceanography
GA 679SF
UT WOS:000284180400004
ER
PT J
AU Koutros, S
Alavanja, MCR
Lubin, JH
Sandler, DP
Hoppin, JA
Lynch, CF
Knott, C
Blair, A
Freeman, LEB
AF Koutros, Stella
Alavanja, Michael C. R.
Lubin, Jay H.
Sandler, Dale P.
Hoppin, Jane A.
Lynch, Charles F.
Knott, Charles
Blair, Aaron
Freeman, Laura E. Beane
TI An Update of Cancer Incidence in the Agricultural Health Study
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID FARMER PESTICIDE APPLICATORS; NON-HODGKINS-LYMPHOMA; B-CELL LYMPHOMA;
PHYSICAL-ACTIVITY; OCCUPATIONAL-EXPOSURE; LUNG-CANCER; PROSTATE-CANCER;
CUTANEOUS MELANOMA; MULTIPLE-MYELOMA; LIP CANCER
AB Objective: Our objective is to reevaluate cancer incidence among Agricultural Health Study participants. Methods: Standardized incidence ratios (SIRs) and relative standardized ratios were calculated. Results: A significant excess of prostate cancer was seen for private and commercial applicators (SIR = 1.19, 95% CI 1.14, 1.25 and SIR = 1.28, 95% CI = 1.00, 1.61, respectively). Excesses were observed for lip cancer (SIR = 1.97, 95% CI = 1.02, 3.44) and multiple myeloma (SIR = 1.42, 95% CI = 1.00, 1.95) among private applicators from North Carolina and for marginal zone lymphoma among Iowa spouses (SIR = 2.34, 95% CI = 1.21, 4.09). Conclusions: Although lower rates of smoking and increased physical activity probably contribute to the lower overall cancer incidence, agricultural exposures including pesticides, viruses, bacteria, sunlight, and other chemicals may increase risks for specific cancer sites.
C1 [Koutros, Stella] NCI, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Rockville, MD 20852 USA.
[Sandler, Dale P.; Hoppin, Jane A.] Natl Inst Environm Hlth Sci, Epidemiol Branch, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC USA.
[Lynch, Charles F.] Univ Iowa, Coll Publ Hlth, Iowa City, IA USA.
[Knott, Charles] Battelle Mem Inst, Durham, NC USA.
RP Koutros, S (reprint author), NCI, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, 6120 Execut Blvd,EPS 8115,MSC 7240, Rockville, MD 20852 USA.
EM koutross@mail.nih.gov
OI Sandler, Dale/0000-0002-6776-0018
FU NIH, National Cancer Institute, Division of Cancer Epidemiology and
Genetics [Z01CP010119]; National Institute of Environmental Health
Sciences [Z01ES049030]
FX This research was supported by the Intramural Research Program of the
NIH, National Cancer Institute, Division of Cancer Epidemiology and
Genetics (Z01CP010119) and National Institute of Environmental Health
Sciences (Z01ES049030).
NR 71
TC 62
Z9 62
U1 1
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1076-2752
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD NOV
PY 2010
VL 52
IS 11
BP 1098
EP 1105
DI 10.1097/JOM.0b013e3181f72b7c
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 678GD
UT WOS:000284061200006
PM 21063187
ER
PT J
AU Chow, JC
Watson, JG
Green, MC
Frank, NH
AF Chow, Judith C.
Watson, John G.
Green, Mark C.
Frank, Neil H.
TI Filter Light Attenuation as a Surrogate for Elemental Carbon
SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION
LA English
DT Article
ID INTEGRATING PLATE METHOD; AIR-QUALITY STANDARDS; BLACK CARBON;
ABSORPTION-MEASUREMENTS; FRESNO SUPERSITE; IMPROVE NETWORK;
ENVIRONMENTAL-IMPACT; CHEMICAL-COMPOSITION; INDEPENDENT ANALYSIS;
OPTICAL-ABSORPTION
AB Light attenuation (b(att)) measured from filter light transmission is compared with elemental carbon (EC) measurements for more than 180,000 collocated PM2.5 (particulate matter [PM] <= 2.5 mu m in aerodynamic diameter) and PM, (PM <= 10 mu m in aerodynamic diameter) samples from nearly 200 U.S. locations during the past 2 decades. Although there are theoretical reasons for expecting highly variable relationships between b(att) and EC (such as the effects of "brown carbon" and iron oxides in PM2.5), reasonable correlations are found. These correlations are not a strong function of season or location (e.g., rural vs. urban). Median EC concentrations can be predicted from filter transmittance measurements to within +/- 15-30%. Although EC predicted from b(att) shows larger uncertainties (30-60%), especially at concentrations less than 0.3 mu g/m(3), the consistent mass absorption efficiency (sigma(att)) derived from the regression analysis demonstrates the feasibility of using b(att) as a surrogate for EC. This study demonstrates that a constant factor of 0.1 g/m(2) (equivalent to the 10 m(2)/g sigma(att) used in the Interagency Monitoring of Protected Visual Environments chemical extinction formula) can be used to estimate EC concentrations from bat, through a Teflon-membrane filter sample. Greater accuracy is achieved with site-specific sigma(att) derived from a period with collocated EC measurements.
C1 [Chow, Judith C.; Watson, John G.; Green, Mark C.] Desert Res Inst, Div Atmospher Sci, Reno, NV 89512 USA.
Chinese Acad Sci, Inst Earth Environm, Aerosol & Environm Div, Xian, Peoples R China.
[Frank, Neil H.] US EPA, Air Qual Assessment Div, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
RP Chow, JC (reprint author), Desert Res Inst, Div Atmospher Sci, 2215 Raggio Pkwy, Reno, NV 89512 USA.
EM judyc@dri.edu
RI Watson, John/E-6869-2010
OI Watson, John/0000-0002-1752-6899
FU EPA/National Park Service [T2350086187]
FX This work was partially supported by the EPA/National Park Service task
number T2350086187. The authors thank Ms. Jo Gerrard for her assistance
in assembling and editing the paper. The information expressed in this
paper does not necessarily reflect the policies of EPA.
NR 79
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Z9 10
U1 1
U2 26
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1096-2247
EI 2162-2906
J9 J AIR WASTE MANAGE
JI J. Air Waste Manage. Assoc.
PD NOV
PY 2010
VL 60
IS 11
BP 1365
EP 1375
DI 10.3155/1047-3289.60.11.1365
PG 11
WC Engineering, Environmental; Environmental Sciences; Meteorology &
Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA 677EL
UT WOS:000283971800009
PM 21141430
ER
PT J
AU Fulper, CR
Kishan, S
Baldauf, RW
Sabisch, M
Warila, J
Fujita, EM
Scarbro, C
Crews, WS
Snow, R
Gabele, P
Santos, R
Tierney, E
Cantrell, B
AF Fulper, Carl R.
Kishan, Sandeep
Baldauf, Richard W.
Sabisch, Michael
Warila, Jim
Fujita, Eric M.
Scarbro, Carl
Crews, William S.
Snow, Richard
Gabele, Peter
Santos, Robert
Tierney, Eugene
Cantrell, Bruce
TI Methods of Characterizing the Distribution of Exhaust Emissions from
Light-Duty, Gasoline-Powered Motor Vehicles in the U.S. Fleet
SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION
LA English
DT Article
ID AIR-POLLUTION SOURCES; ORGANIC-COMPOUNDS; SOURCE APPORTIONMENT; DIESEL
TRUCKS; AEROSOL; TRACERS
AB Mobile sources significantly contribute to ambient concentrations of airborne particulate matter (PM). Source apportionment studies for PM(10) (PM <= 10 mu m in aerodynamic diameter) and PM(2.5) (PM <= 2.5 mu m in aerodynamic diameter) indicate that mobile sources can be responsible for over half of the ambient PM measured in an urban area. Recent source apportionment studies attempted to differentiate between contributions from gasoline and diesel motor vehicle combustion. Several source apportionment studies conducted in the United States suggested that gasoline combustion from mobile sources contributed more to ambient PM than diesel combustion. However, existing emission inventories for the United States indicated that diesels contribute more than gasoline vehicles to ambient PM concentrations. A comprehensive testing program was initiated in the Kansas City metropolitan area to measure PM emissions in the light-duty, gasoline-powered, on-road mobile source fleet to provide data for PM inventory and emissions modeling. The vehicle recruitment design produced a sample that could represent the regional fleet, and by extension, the national fleet. All vehicles were recruited from a stratified sample on the basis of vehicle class (car, truck) and model-year group. The pool of available vehicles was drawn primarily from a sample of vehicle owners designed to represent the selected demographic and geographic characteristics of the Kansas City population. Emissions testing utilized a portable, light-duty chassis dynamometer with vehicles tested using the LA-92 driving cycle, on-board emissions measurement systems, and remote sensing devices. Particulate mass emissions were the focus of the study, with continuous and integrated samples collected. In addition, sample analyses included criteria gases (carbon monoxide, carbon dioxide, nitric oxide/nitrogen dioxide, hydrocarbons), air toxics (speciated volatile organic compounds), and PM constituents (elemental/organic carbon, metals, semi-volatile organic compounds). Results indicated that PM emissions from the in-use fleet varied by up to 3 orders of magnitude, with emissions generally increasing for older model-year vehicles. The study also identified a strong influence of ambient temperature on vehicle PM mass emissions, with rates increasing with decreasing temperatures.
C1 [Baldauf, Richard W.; Gabele, Peter] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Fulper, Carl R.; Baldauf, Richard W.; Warila, Jim; Scarbro, Carl; Tierney, Eugene; Cantrell, Bruce] US EPA, Natl Vehicle & Fuel Emiss Lab, Off Transportat & Air Qual, Ann Arbor, MI USA.
[Kishan, Sandeep; Sabisch, Michael] Eastern Res Grp, Austin, TX USA.
[Fujita, Eric M.] Univ Nevada, Desert Res Inst, Reno, NV 89506 USA.
[Crews, William S.; Snow, Richard] Bevilaqua Knight Inc, Res Triangle Pk, NC USA.
[Santos, Robert] NuStats, Austin, TX USA.
RP Baldauf, RW (reprint author), US EPA, Natl Risk Management Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
EM baldauf.richard@epa.gov
NR 16
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U1 3
U2 20
PU AIR & WASTE MANAGEMENT ASSOC
PI PITTSBURGH
PA ONE GATEWAY CENTER, THIRD FL, PITTSBURGH, PA 15222 USA
SN 1047-3289
J9 J AIR WASTE MANAGE
JI J. Air Waste Manage. Assoc.
PD NOV
PY 2010
VL 60
IS 11
BP 1376
EP 1387
DI 10.3155/1047-3289.60.11.1376
PG 12
WC Engineering, Environmental; Environmental Sciences; Meteorology &
Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA 677EL
UT WOS:000283971800010
PM 21141431
ER
PT J
AU Kleindienst, TE
Lewandowski, M
Offenberg, JH
Edney, EO
Jaoui, M
Zheng, M
Ding, XA
Edgerton, ES
AF Kleindienst, Tadeusz E.
Lewandowski, Michael
Offenberg, John H.
Edney, Edward O.
Jaoui, Mohammed
Zheng, Mei
Ding, Xiang
Edgerton, Eric S.
TI Contribution of Primary and Secondary Sources to Organic Aerosol and
PM2.5 at SEARCH Network Sites
SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION
LA English
DT Article
ID AIR-POLLUTION SOURCES; UNITED-STATES; SOURCE APPORTIONMENT; PARTICULATE
MATTER; HYDROXYL-GROUPS; EMISSIONS; CARBON; QUANTIFICATION;
IDENTIFICATION; COMBUSTION
AB Chemical tracer methods for determining contributions to primary organic aerosol (POA) are fairly well established, whereas similar techniques for secondary organic aerosol (SOA), inherently complicated by time-dependent atmospheric processes, are only beginning to be studied. Laboratory chamber experiments provide insights into the precursors of SOA, but field data must be used to test the approaches. This study investigates primary and secondary sources of organic carbon (OC) and determines their mass contribution to particulate matter 2.5 mu m or less in aerodynamic diameter (PM2.5) in Southeastern Aerosol Research and Characterization (SEARCH) network samples. Filter samples were taken during 20 24-hr periods between May and August 2005 at SEARCH sites in Atlanta, GA (JST); Birmingham, AL (BHM); Centerville, AL (CTR); and Pensacola, FL (PNS) and analyzed for organic tracers by gas chromatography-mass spectrometry. Contribution to primary OC was made using a chemical mass balance method and to secondary OC using a mass fraction method. Aerosol masses were reconstructed from the contributions of POA, SOA, elemental carbon, inorganic ions (sulfate [SO42-], nitrate [NO3-], ammonium [NH4+]), metals, and metal oxides and compared with the measured PM2.5. From the analysis, OC contributions from seven primary sources and four secondary sources were determined. The major primary sources of carbon were from wood combustion, diesel and gasoline exhaust, and meat cooking; major secondary sources were from isoprene and monoterpenes with minor contributions from toluene and beta-caryophyllene SOA. Mass concentrations at the four sites were determined using source-specific organic mass (OM)-to-OC ratios and gave values in the range of 12-42 mu g m(-3). Reconstructed masses at three of the sites (JST, CTR, PNS) ranged from 87 to 91% of the measured PM2.5 mass. The reconstructed mass at the BHM site exceeded the measured mass by approximately 25%. The difference between the reconstructed and measured PM2.5 mass for nonindustrial areas is consistent with not including aerosol liquid water or other sources of organic aerosol.
C1 [Kleindienst, Tadeusz E.; Lewandowski, Michael; Offenberg, John H.; Edney, Edward O.] US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Jaoui, Mohammed] Alion Sci & Technol, Res Triangle Pk, NC USA.
[Zheng, Mei; Ding, Xiang] Georgia Inst Technol, Sch Earth & Atmospher Sci, Atlanta, GA 30332 USA.
[Edgerton, Eric S.] Atmospher Res & Anal Inc, Cary, NC USA.
RP Kleindienst, TE (reprint author), US EPA, Natl Exposure Res Lab, Off Res & Dev, Mail Drop D 205-03, Res Triangle Pk, NC 27711 USA.
EM kleindienst.tad@epa.gov
RI Offenberg, John/C-3787-2009; Wang, Linden/M-6617-2014; Ding,
Xiang/C-7018-2012
OI Offenberg, John/0000-0002-0213-4024; Ding, Xiang/0000-0002-1218-1879
FU U.S. Environmental Protection Agency through its Office of Research and
Development [EP-D-05-065]; Southern Company
FX The U.S. Environmental Protection Agency through its Office of Research
and Development funded and collaborated in the research described here
under contract EP-D-05-065 to Alion Science and Technology. The
manuscript is subjected to external peer review and has been cleared for
publication. Mention of trade names or commercial products does not
constitute an endorsement or recommendation for use. The Southern
Company also provided funding for this study. The authors thank
Professor James J. Schauer (University of Wisconsin-Madison) for help
with the quantification standards for primary tracers and the SEARCH
field group for their assistance with sample collection.
NR 42
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U1 3
U2 44
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1096-2247
J9 J AIR WASTE MANAGE
JI J. Air Waste Manage. Assoc.
PD NOV
PY 2010
VL 60
IS 11
BP 1388
EP 1399
DI 10.3155/1047-3289.60.11.1388
PG 12
WC Engineering, Environmental; Environmental Sciences; Meteorology &
Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA 677EL
UT WOS:000283971800011
PM 21141432
ER
PT J
AU Phillips, PM
Jarema, KA
Kurtz, DM
MacPhail, RC
AF Phillips, Pamela M.
Jarema, Kimberly A.
Kurtz, David M.
MacPhail, Robert C.
TI An Observational Assessment Method for Aging Laboratory Rats
SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
LA English
DT Article
ID POPULATION; MOUSE
AB The rapid growth of the aging human population highlights the need for laboratory animal models to study the basic biologic processes of aging and susceptibility to disease, drugs, and environmental pollutants Methods are needed to evaluate the health of aging animals over time, particularly methods for efficiently monitoring large research colonies Here we describe an observational assessment method that scores appearance, posture, mobility, and muscle tone on a 5-point scale that can be completed in about 1 min A score of 1 indicates no deterioration, whereas a score of 5 indicates severe deterioration Tests were applied to male Brown Norway rats between 12 and 36 mo of age (n = 32) The rats were participating concurrently in experiments on the behavioral effects of intermittent exposure (approximately every 4 mo) to short-acting environmental chemicals Results demonstrated that aging-related signs of deterioration did not appear before 18 mo of age Assessment scores and variability then increased with age Body weights increased until approximately 24 mo, then remained stable, but decreased after 31 mo for the few remaining rats The incidence of death increased slightly from 20 to 28 mo of age and then rose sharply, median survival age was approximately 30 mo, with a maximum of 36 mo The results indicate that our observational assessment method supports efficient monitoring of the health of aging rats and may be useful in studies on susceptibility to diseases, drugs, and toxicants during old age
C1 [Phillips, Pamela M.; Jarema, Kimberly A.; MacPhail, Robert C.] US EPA, Neurotoxicol Branch, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Kurtz, David M.] Expt Pathol Labs, Res Triangle Pk, NC USA.
RP MacPhail, RC (reprint author), US EPA, Neurotoxicol Branch, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
NR 33
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Z9 6
U1 5
U2 7
PU AMER ASSOC LABORATORY ANIMAL SCIENCE
PI MEMPHIS
PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA
SN 1559-6109
J9 J AM ASSOC LAB ANIM
JI J. Amer. Assoc. Lab. Anim. Sci.
PD NOV
PY 2010
VL 49
IS 6
BP 792
EP 799
PG 8
WC Veterinary Sciences; Zoology
SC Veterinary Sciences; Zoology
GA 687PZ
UT WOS:000284791700001
PM 21205442
ER
PT J
AU Hart, WE
Murray, R
AF Hart, William E.
Murray, Regan
TI Review of Sensor Placement Strategies for Contamination Warning Systems
in Drinking Water Distribution Systems
SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT-ASCE
LA English
DT Article
DE Optimization; Drinking water; Security; Sensors
ID DETECTING ACCIDENTAL CONTAMINATIONS; MONITORING STATIONS; DISTRIBUTION
NETWORKS; IMPERFECT SENSORS; OPTIMIZATION; QUALITY; DESIGN; MODELS;
ALGORITHMS; SECURITY
AB Contamination warning systems (CWSs) are a promising approach for the mitigation of contamination risks in drinking water distribution systems. A critical aspect of the design of a CWS is the strategic placement of online sensors that rapidly detect contaminants. This paper reviews the array of optimization-based sensor placement strategies that have been recently proposed. These strategies are critiqued and several key issues are identified that need to be addressed in future work.
C1 [Hart, William E.] Sandia Natl Labs, Albuquerque, NM 87185 USA.
[Murray, Regan] US EPA, Natl Homeland Secur Res Ctr, Cincinnati, OH 45268 USA.
RP Hart, WE (reprint author), Sandia Natl Labs, POB 5800, Albuquerque, NM 87185 USA.
EM wehart@sandia.gov; Murray.Regan@epa.gov
FU U.S. EPA through its Office of Research and Development [DW8992192801];
DOE, Sandia National Laboratories; U.S. DOE's National Nuclear Security
Administration [DE-AC04-94AL85000]
FX The U.S. EPA through its Office of Research and Development funded and
collaborated in the research described here under Interagency Agreement
No. DW8992192801 with the DOE, Sandia National Laboratories. This paper
has been subjected to the Agency's review and has been approved for
publication. Sandia is a multiprogram laboratory operated by Sandia
Corporation, a Lockheed Martin Company, for the U.S. DOE's National
Nuclear Security Administration under Contract No. DE-AC04-94AL85000.
The views and opinions expressed herein do not necessarily state or
reflect those of the Agency, the U.S. Government, or the Sandia
Corporation.
NR 87
TC 57
Z9 58
U1 2
U2 33
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-9496
J9 J WATER RES PL-ASCE
JI J. Water Resour. Plan. Manage.-ASCE
PD NOV-DEC
PY 2010
VL 136
IS 6
BP 611
EP 619
DI 10.1061/(ASCE)WR.1943-5452.0000081
PG 9
WC Engineering, Civil; Water Resources
SC Engineering; Water Resources
GA 670HK
UT WOS:000283411600002
ER
PT J
AU Tryby, ME
Propato, M
Ranjithan, SR
AF Tryby, Michael E.
Propato, Marco
Ranjithan, S. Ranji
TI Monitoring Design for Source Identification in Water Distribution
Systems
SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT-ASCE
LA English
DT Article
DE Source identification; Monitoring design; Inverse problem; Experimental
design; Water distribution systems; Water infrastructure security;
Genetic algorithm; Optimization
ID SENSOR PLACEMENT; DISTRIBUTION NETWORKS; BOOSTER DISINFECTION;
CONTAMINATION; STATIONS; MODEL; OPTIMIZATION; ALGORITHM; QUALITY; OUTPUT
AB The design of sensor networks for monitoring contaminants in water distribution systems is currently an active area of research. Much of the effort has been directed at the contamination detection problem and the expression of public health protection objectives. Monitoring networks once they are in place, however, are likely to be used to gather monitoring data for source inversion as well. Thus, the design of these networks with the unique objectives associated with source inversion problems in mind is a necessity. Source inversion problems in water distribution systems are inherently underdetermined and exhibit solution nonuniqueness; and moreover, the structure of the errors associated with a solution are a function of monitoring observations. Optimal inverse experiment design is investigated as an approach for improving solution quality. The approach involves the selection of monitoring locations that are best suited to the generation of a well-conditioned source identification inverse problem. The monitoring design problem is formulated as a nonlinear combinatorial optimization problem and solved using a genetic algorithm. The monitoring designs generated exhibit an optimal substructure that may be exploited to develop more efficient methods of solution. An analysis is conducted to evaluate the source inversion performance of an optimized monitoring network relative to networks designed using different methods. The results of the analysis demonstrate that when the source identification problem is underdetermined, the number of monitoring sensors installed in the network is more important than the method used to locate them.
C1 [Tryby, Michael E.] US EPA, Ecosyst Res Div, NERL, Athens, GA 30605 USA.
[Propato, Marco] Cemagref, UR REBX, F-33612 Cestas, France.
[Ranjithan, S. Ranji] N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA.
RP Tryby, ME (reprint author), US EPA, Ecosyst Res Div, NERL, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM Tryby.Michael@epa.gov
FU National Science Foundation [BES-0238623]
FX This work was partially funded under National Science Foundation Grant
No. BES-0238623. The writers would like to thank Dr. G. Mahinthakumar
and his students for sharing the computational resources that made the
analyses conducted possible. The content of this paper has undergone
U.S. Environmental Protection Agency internal review. This, however,
does not imply official endorsement of the views expressed herein.
NR 35
TC 8
Z9 10
U1 0
U2 9
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-9496
J9 J WATER RES PL-ASCE
JI J. Water Resour. Plan. Manage.-ASCE
PD NOV-DEC
PY 2010
VL 136
IS 6
BP 637
EP 646
DI 10.1061/(ASCE)WR.1943-5452.0000080
PG 10
WC Engineering, Civil; Water Resources
SC Engineering; Water Resources
GA 670HK
UT WOS:000283411600005
ER
PT J
AU Cannon, CZ
Kissling, GE
Hoenerhoff, MJ
King-Herbert, AP
Blankenship-Paris, T
AF Cannon, Coralie Zegre
Kissling, Grace E.
Hoenerhoff, Mark J.
King-Herbert, Angela P.
Blankenship-Paris, Terry
TI Evaluation of dosages and routes of administration of tramadol analgesia
in rats using hot-plate and tail-flick tests
SO LAB ANIMAL
LA English
DT Article
ID TRANS-O-DEMETHYLTRAMADOL; ACTIVE METABOLITE; IN-VITRO; PAIN; MODEL;
EFFICACY; BUPRENORPHINE; MORPHINE; MOUSE; PHARMACOKINETICS
AB Tramadol is an opioid-Like analgesic with relatively mild side effects. Because it is inexpensive and is not classified as a controlled substance by the US federal government, the authors wanted to evaluate its applicability as a practical and effective analgesic in male Sprague Dawley rats. They measured the efficacy of four dosages (4, 12.5, 25 or 50 mg tramadol per kg body weight) and three routes of administration (per os (p.o.) in a flavored gelatin cube, subcutaneous (s.c.) or intraperitoneal (i.p.)) using the hot-plate test and the tail-flick test, which were carried out 1 week apart. Rats that were dosed p.o. were given flavored gelatin cubes without tramadol on the 2 d before testing to help them become acclimated to the gelatin, in an effort to increase the likelihood that they would consume the gelatin on the testing day. Results from the hot-plate and tail-flick tests for rats that were given tramadol p.o. were similar before and after administration, regardless of tramadol dosage, suggesting that this route of administration was not effective. The s.c. route of administration was effective at dosages of 25 mg and 50 mg tramadol per kg body weight, although these dosages also resulted in sedation and skin lesions. The i.p. route of administration was also effective at dosages of 12.5 mg, 25 mg and 50 mg tramadol per kg body weight, though sedation was observed at dosages of 25 mg and 50 mg per kg body weight. Intraperitoneal administration of 12.5 mg tramadol per kg body weight had no notable side effects, and the authors plan to further study this dosage and route of administration in a rodent surgical model of pain.
C1 [Cannon, Coralie Zegre; Hoenerhoff, Mark J.; King-Herbert, Angela P.] Natl Inst Environm Hlth Sci, Cellular & Mol Pathol Branch, Res Triangle Pk, NC USA.
[Kissling, Grace E.] Natl Inst Environm Hlth Sci, Biostat Branch, Res Triangle Pk, NC USA.
[Blankenship-Paris, Terry] Natl Inst Environm Hlth Sci, Comparat Med Branch, Res Triangle Pk, NC USA.
RP Cannon, CZ (reprint author), Natl Inst Environm Hlth Sci, Cellular & Mol Pathol Branch, Res Triangle Pk, NC USA.
EM cannonc@niehs.nih.gov
FU National Institutes of Health; National Institute of Environmental
Health Sciences
FX We thank Danielle Waxer, Page Myers, James Clark, Sandy Hackney, Jenetta
Jackson and Keisha Chavis for their assistance and support of the
research and care of the animals. We thank Dr. Larry Wright for
assistance in literature evaluation. We thank Dr. Sheryl Moy, Dr. Greg
Travlos and Dr. Gregory Cannon for their extensive reviews of the
manuscript. This research was supported by the Intramural Research
Program of the National Institutes of Health and the National Institute
of Environmental Health Sciences.
NR 47
TC 13
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U1 0
U2 12
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0093-7355
J9 LAB ANIMAL
JI Lab Anim.
PD NOV
PY 2010
VL 39
IS 11
BP 342
EP 351
PG 12
WC Veterinary Sciences
SC Veterinary Sciences
GA 674RR
UT WOS:000283766100011
PM 20962760
ER
PT J
AU Schipper, CA
Rietjens, IMCM
Burgess, RM
Murk, AJ
AF Schipper, C. A.
Rietjens, I. M. C. M.
Burgess, R. M.
Murk, A. J.
TI Application of bioassays in toxicological hazard, risk and impact
assessments of dredged sediments
SO MARINE POLLUTION BULLETIN
LA English
DT Article
DE In vitro; In vivo; Bioassay; Hazard and risk assessment; Dredged
sediment; Dioxins; TBT; Licensing system
ID IN-VITRO BIOASSAY; POLYHALOGENATED AROMATIC-HYDROCARBONS; MARINE HARBOR
SEDIMENTS; DIOXIN-LIKE COMPOUNDS; REPORTER GENE ASSAYS; NORTH-SEA;
ESTROGENIC ACTIVITY; EXPRESSION CALUX; DUTCH MARINE; LUTRA-LUTRA
AB Given the potential environmental consequences of dumped dredged harbour sediments it is vital to establish the potential risks from exposure before disposal at sea. Currently, European legislation for disposal of contaminated sediments at sea is based on chemical analysis of a limited number of well-known contaminants for which maximum acceptable concentrations, action levels (ALs), have been set. The present paper addresses the issue of the applicability of in vitro and in vivo bioassays for hazard, risk and local impact assessment of dredged polluted sediments to be disposed of at sea. It discusses how and to what extent selected bioassays can fill in the gaps left open by chemical analysis and the way in which the bioassays may contribute to the present licensing system for disposal. Three different purposes for application were distinguished: the most basic application (A) is a rapid determination of the hazard (potential toxicity) of dredged sediments which is then compared to ALs in a licensing system. As with chemical analysis on whole sediment extracts, the bioavailability of the chemicals is not taken into account. As in vitro assays with sediment extracts are not sensitive to matrix effects, a selection of specific in vitro bioassays can be suitable fast and standardized additions for the licensing system. When the outcome of (A) does not convincingly demonstrate whether the sediment is clean enough or too polluted, further bioanalysis can help the decision making process (B). More aspects of the mostly unknown complex chemical mixtures are taken into account, including the bioavailability and chronic toxicity focusing on ecologically relevant endpoints. The ecotoxicological pressure imposed by the dredged sediments can be quantified as the potentially affected fraction (PAF) based on chemical or biological analysis of levels of contaminants in sediment or biota. To validate the predicted risk, the actual impact of dumped harbour sediments on local ecosystems (C) can be determined using a dedicated set of in vitro and in vivo bioassays as well as bio-indicators selected based on the information obtained from (A) and (B) and on the characteristics of the local ecosystem. Conversely, the local sediment impact assessment (C) can direct fine-tuning of the selection of chemical and bioassay analyses and for setting safe levels in the licensing system. It is concluded that in vitro and in vivo bioassays and biological indicators are useful tools in the process of hazard, ecotoxicological risk and impact assessment of dredged harbour sediments, provided they are consciously chosen and quality criteria for assay performance are defined. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Schipper, C. A.] Deltares, NL-2600 MH Delft, Netherlands.
[Rietjens, I. M. C. M.; Murk, A. J.] Wageningen Univ, Toxicol Sect, NL-6700 EA Wageningen, Netherlands.
[Burgess, R. M.] US EPA, ORD NHEERL, Atlantic Ecol Div, Narragansett, RI 02882 USA.
[Murk, A. J.] Wageningen Imares, NL-1970 AB Ijmuiden, Netherlands.
RP Schipper, CA (reprint author), Deltares, POB 177, NL-2600 MH Delft, Netherlands.
EM cor.schipper@deltares.nl
OI Rietjens, Ivonne/0000-0003-1894-3544
FU Directorate-General of Public Works and Water Management
(Rijkswaterstaat, RWS)
FX We would like to acknowledge the valuable contribution in terms of
financial support made by the Directorate-General of Public Works and
Water Management (Rijkswaterstaat, RWS). The authors wish to thank
Gmelig Meyling (Stichting ANEMOON), Klaas Kaag (IMARES) and Johan Jol
(IMARES) for their invaluable support in conducting the fieldwork. This
paper benefited greatly from the input of colleagues at RWS including
Hans Klamer, Martine van den Heuvel-Greve (Deltares), and Jos van Gils
(Deltares). We are grateful to Dick de Zwart (RIVM) and Lou Verhage
(Deltares) for their support on the msPAF calculations and Pim Leonards
(IVM) for the analysis of the seal samples. We would like to thank both
reviewers for their time devoted to our manuscript since we feel their
comments helped to improve the scientific quality of the manuscript.
NR 110
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U1 3
U2 26
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0025-326X
EI 1879-3363
J9 MAR POLLUT BULL
JI Mar. Pollut. Bull.
PD NOV
PY 2010
VL 60
IS 11
BP 2026
EP 2042
DI 10.1016/j.marpolbul.2010.07.018
PG 17
WC Environmental Sciences; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA 685YA
UT WOS:000284662800025
PM 20850157
ER
PT J
AU Sturza, J
AF Sturza, Julie
TI A Review and Meta-Analysis of Utility Values for Lung Cancer
SO MEDICAL DECISION MAKING
LA English
DT Review
DE cost utility analysis; randomized trial methodology; risk
stratification; population-based studies; scale development/validation
ID QUALITY-OF-LIFE; COST-EFFECTIVENESS ANALYSIS; DECISION-ANALYSIS;
PALLIATIVE RADIOTHERAPY; PATIENTS PERCEPTIONS; ECONOMIC-EVALUATION;
HEALTH STATES; PREFERENCES; OUTCOMES; DISEASE
AB Background. Published utility estimates for lung cancer are plentiful and vary greatly. The reason for this variability is unclear, but may result from differences in the methods used to elicit each utility. Purpose. To identify a set of pooled lung cancer utility estimates reflective of the available literature and determine which methodological factors significantly influence the value of lung cancer utility. Data Sources. Searches of PubMed, the NHS Economic Evaluation Database, and the Cost Effectiveness Analysis Registry from the Center for the Evaluation of Value and Risk in Health. Study Selection. English-language studies were included if they presented at least one previously unpublished lung cancer utility value, noted the elicitation technique and utility value provider. Data Extraction and Analysis. Two trained readers independently reviewed each article and extracted information for analysis. A hierarchical linear model (HLM) was used to perform a meta-regression with cancer stage, lower bound of scale, upper bound of scale, respondent, elicitation method, and lung cancer subtype as explanatory variables. Data Synthesis. Twenty-three articles containing 223 unique utility values were included. Lung cancer stage and subtype, the upper bound label of the utility scale, and respondent identity were significant predictors of utility (P < 0.05), while the lower bound label of utility scale was not. The HLM provided a set of pooled utility values for metastatic (0.57), mixed or nonspecified stage (0.77), and nonmetastatic lung cancer (0.87)-for the case of standard gamble as method, patients as respondents, non-small-cell lung cancer and scale labeled death to perfect health. Conclusion. Methodological factors significantly affect lung cancer utilities; therefore, analysts should avoid direct comparisons of lung cancer utility values elicited with dissimilar methods.
C1 [Sturza, Julie] US EPA, Off Policy Econ & Innovat, Washington, DC 20460 USA.
RP Sturza, J (reprint author), 1200 Penn Ave NW 1809T, Washington, DC 20460 USA.
EM sturza.julie@epa.gov
NR 61
TC 21
Z9 21
U1 1
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0272-989X
J9 MED DECIS MAKING
JI Med. Decis. Mak.
PD NOV-DEC
PY 2010
VL 30
IS 6
BP 685
EP 693
DI 10.1177/0272989X10369004
PG 9
WC Health Care Sciences & Services; Medical Informatics
SC Health Care Sciences & Services; Medical Informatics
GA 698FU
UT WOS:000285580100006
PM 20448248
ER
PT J
AU Andree, K
Axtner, J
Bagley, MJ
Barlow, EJ
Beebee, TJC
Bennetzen, JL
Bermingham, E
Boisselier-Dubayle, MC
Bozarth, CA
Brooks, CP
Brown, RP
Catanese, G
Cavers, S
Ceron-Souza, I
Chak, STC
Chan, MN
Charles-Dominique, P
Chen, CY
Chen, JD
Chinchilla, L
Da Silva, D
Dafreville, S
Daunt, F
Delatte, H
Dorge, T
Duncan, N
Durand, JD
Duvernell, D
Estep, M
Fan, S
Fattahi, R
Villela, OF
Fong, Y
Freville, H
Funes, V
Gallardo-Escarate, C
Ganeshaiah, KN
Ghaffari, MR
Girod, C
Gomez-Moliner, BJ
Gonzalez-Porter, GP
Gosa, A
Govers, F
Guerin, F
Guindo, D
Hailer, F
Haye, PA
Hoelmer, KA
Hofmann, S
Hong, Y
Hu, CQ
Huang, SW
Humeau, L
Infante, C
Jackson, SA
Jacobsen, E
Jowkar, A
Kafi, M
Kermani, MJ
Kim, H
Kim, KS
Kim, MY
Knibb, W
Koita, OA
Korpelainen, H
Lambourdiere, J
Lasso, E
Leblois, R
Lee, H
Lee, SW
Leung, FCC
Leung, KMY
Li, CH
Li, Y
Lieckfeldt, D
Lizana, M
Loughry, WJ
Luo, P
Madeira, MJ
Mahmoodi, P
Maldonado, JE
Mardi, M
Mendes, O
Miehe, G
Muth, P
Nacci, D
Kumar, LN
Ng, WC
Pailler, T
Parzies, HK
Perez, L
Pfunder, M
Pietilaeinen, M
Pirseyedi, SM
Porta, D
Porta, J
Porta, JM
Quilici, S
Rakotoarivelo, FP
Ramesha, BT
Ravikanth, G
Riera, B
Risterucci, AM
Roberts, DA
Samadi, S
Sarasola-Puente, V
Sarrazin, E
Sarthou, C
Schmidt, A
Segovia, NI
Shen, KN
Simiand, C
Bin Sman, MH
Solhoy, T
Sommer, S
Sumangala, RC
Taubert, R
Tejangkura, T
Telford, A
Testa, A
Tollon-Cordet, C
Tzeng, WN
Shaanker, RU
van der Lee, TAJ
Van Mourik, TA
Vasudeva, R
Wai, TC
Wang, RL
Welch, ME
Weltzien, E
Whitehead, A
Woodard, A
Xia, JJ
Zeinolabedini, M
Zhang, L
AF Andree, K.
Axtner, Jan
Bagley, M. J.
Barlow, E. J.
Beebee, T. J. C.
Bennetzen, Jeffrey L.
Bermingham, Eldredge
Boisselier-Dubayle, M. C.
Bozarth, Christine A.
Brooks, Christopher P.
Brown, R. P.
Catanese, Gaetano
Cavers, S.
Ceron-Souza, Ivania
Chak, Solomon T. C.
Chan, M. N.
Charles-Dominique, P.
Chen, C. Y.
Chen, J. D.
Chinchilla, Leah
Da Silva, D.
Dafreville, S.
Daunt, F.
Delatte, H.
Dorge, T.
Duncan, N.
Durand, J. D.
Duvernell, D.
Estep, Matt
Fan, Sigang
Fattahi, R.
Villela, Oscar Flores
Fong, Yokking
Freville, H.
Funes, Victoria
Gallardo-Escarate, C.
Ganeshaiah, K. N.
Ghaffari, M. R.
Girod, C.
Gomez-Moliner, B. J.
Gonzalez-Porter, Gracia P.
Gosa, A.
Govers, F.
Guerin, F.
Guindo, Diarah
Hailer, Frank
Haye, P. A.
Hoelmer, Kim A.
Hofmann, S.
Hong, Yan
Hu, Chaoqun
Huang, S. W.
Humeau, L.
Infante, Carlos
Jackson, S. A.
Jacobsen, E.
Jowkar, A.
Kafi, M.
Kermani, M. J.
Kim, Hyojoong
Kim, Kyung Seok
Kim, Min-Young
Knibb, W.
Koita, Ousmane A.
Korpelainen, H.
Lambourdiere, J.
Lasso, Eloisa
Leblois, R.
Lee, Hang
Lee, Seungh-Wan
Leung, F. C. C.
Leung, Kenneth M. Y.
Li, Chunhong
Li, Y.
Lieckfeldt, Dietmar
Lizana, M.
Loughry, W. J.
Luo, Peng
Madeira, M. J.
Mahmoodi, P.
Maldonado, Jesus E.
Mardi, M.
Mendes, O.
Miehe, G.
Muth, Peter
Nacci, D.
Kumar, L. Naveen
Ng, Wai-Chuen
Pailler, T.
Parzies, Heiko K.
Perez, Laura
Pfunder, M.
Pietilaeinen, M.
Pirseyedi, S. M.
Porta, D.
Porta, J.
Porta, J. M.
Quilici, S.
Rakotoarivelo, F. P.
Ramesha, B. T.
Ravikanth, G.
Riera, B.
Risterucci, A. M.
Roberts, D. A.
Samadi, S.
Sarasola-Puente, V.
Sarrazin, E.
Sarthou, C.
Schmidt, Anke
Segovia, N. I.
Shen, K. N.
Simiand, C.
Bin Sman, Muhammad Hidayat
Solhoy, T.
Sommer, Simone
Sumangala, R. C.
Taubert, Ramona
Tejangkura, T.
Telford, A.
Testa, A.
Tollon-Cordet, C.
Tzeng, W. N.
Shaanker, R. Uma
van der Lee, T. A. J.
Van Mourik, Thomas A.
Vasudeva, R.
Wai, T. C.
Wang, R. L.
Welch, Mark E.
Weltzien, Eva
Whitehead, A.
Woodard, Anastasia
Xia, Jianjun
Zeinolabedini, M.
Zhang, Lvping
CA Mol Ecology Resources Primer Dev C
TI Permanent Genetic Resources added to Molecular Ecology Resources
Database 1 April 2010-31 May 2010
SO MOLECULAR ECOLOGY RESOURCES
LA English
DT Article
AB This article documents the addition of 396 microsatellite marker loci to the Molecular Ecology Resources Database. Loci were developed for the following species: Anthocidaris crassispina, Aphis glycines, Argyrosomus regius, Astrocaryum sciophilum, Dasypus novemcinctus, Delomys sublineatus, Dermatemys mawii, Fundulus heteroclitus, Homalaspis plana, Jumellea rossii, Khaya senegalensis, Mugil cephalus, Neoceratitis cyanescens, Phalacrocorax aristotelis, Phytophthora infestans, Piper cordulatum, Pterocarpus indicus, Rana dalmatina, Rosa pulverulenta, Saxifraga oppositifolia, Scomber colias, Semecarpus kathalekanensis, Stichopus monotuberculatus, Striga hermonthica, Tarentola boettgeri and Thermophis baileyi. These loci were cross-tested on the following species: Aphis gossypii, Sooretamys angouya, Euryoryzomys russatus, Fundulus notatus, Fundulus olivaceus, Fundulus catenatus, Fundulus majalis, Jumellea fragrans, Jumellea triquetra Jumellea recta, Jumellea stenophylla, Liza richardsonii, Piper marginatum, Piper aequale, Piper darienensis, Piper dilatatum, Rana temporaria, Rana iberica, Rana pyrenaica, Semecarpus anacardium, Semecarpus auriculata, Semecarpus travancorica, Spondias acuminata, Holigarna grahamii, Holigarna beddomii, Mangifera indica, Anacardium occidentale, Tarentola delalandii, Tarentola caboverdianus and Thermophis zhaoermii.
C1 [Andree, K.; Duncan, N.; Mol Ecology Resources Primer Dev C] IRTA St Carles Rapita, San Carlos de la Rapita 43540, Spain.
[Axtner, Jan; Lieckfeldt, Dietmar; Schmidt, Anke; Sommer, Simone; Taubert, Ramona] Leibniz Inst Zoo & Wild life Res, D-10315 Berlin, Germany.
[Bagley, M. J.; Jackson, S. A.; Wang, R. L.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
[Barlow, E. J.; Cavers, S.; Daunt, F.; Telford, A.] NERC Ctr Ecol & Hydrol, CEH Edinburgh, Penicuik EH26 0QB, Midlothian, Scotland.
[Barlow, E. J.] Univ Aberdeen, Sch Biol Sci, Aberdeen AB24 2TZ, Scotland.
[Beebee, T. J. C.] Univ Sussex, Sch Life Sci, Dept Biochem, Brighton BN1 9QG, E Sussex, England.
[Bennetzen, Jeffrey L.] Univ Georgia, Dept Genet, Athens, GA 30602 USA.
[Bermingham, Eldredge; Ceron-Souza, Ivania; Lasso, Eloisa] Smithsonian Trop Res Inst, Panama City 084303092, Panama.
[Boisselier-Dubayle, M. C.; Lambourdiere, J.; Sarrazin, E.] CNRS, Serv Systemat Mol, UMS 2700, F-75231 Paris 05, France.
[Boisselier-Dubayle, M. C.; Lambourdiere, J.; Samadi, S.] CNRS, UPMC IRD MNHN, UMR 7138, F-75231 Paris 05, France.
[Bozarth, Christine A.; Gonzalez-Porter, Gracia P.; Hailer, Frank; Maldonado, Jesus E.] Smithsonian Conservat Biol Inst, Ctr Conservat & Evolutionary Genet, Washington, DC 20008 USA.
[Brooks, Christopher P.; Chinchilla, Leah; Welch, Mark E.; Woodard, Anastasia] Mississippi State Univ, Dept Biol Sci, Mississippi State, MS 39762 USA.
[Brown, R. P.; Tejangkura, T.] Liverpool John Moores Univ, Sch Nat Sci & Psychol, Liverpool L3 3AF, Merseyside, England.
[Catanese, Gaetano; Funes, Victoria; Infante, Carlos; Perez, Laura] Consejeria Agr & Pesca, Lab Identificac Especies Pesqueras & Acuicolas, IFAPA Ctr El Toruno, Cadiz 11500, Spain.
[Chak, Solomon T. C.; Leung, Kenneth M. Y.; Ng, Wai-Chuen; Wai, T. C.] Univ Hong Kong, Swire Inst Marine Sci, Hong Kong, Hong Kong, Peoples R China.
[Chak, Solomon T. C.; Leung, Kenneth M. Y.; Ng, Wai-Chuen; Wai, T. C.] Univ Hong Kong, Div Ecol & Biodivers, Sch Biol Sci, Hong Kong, Hong Kong, Peoples R China.
[Charles-Dominique, P.; Freville, H.] CEFE CNRS, Museum Natl Hist Nat, F-34293 Montpellier 05, France.
[Chen, C. Y.; Chen, J. D.] Natl Taiwan Ocean Univ, Dept Aquaculture, Chilung, Taiwan.
[Da Silva, D.; Dafreville, S.; Guerin, F.; Humeau, L.; Pailler, T.; Rakotoarivelo, F. P.] Univ La Reunion, UMR PVBMT, St Denis 97715, Reunion.
[Delatte, H.; Quilici, S.; Simiand, C.] Univ La Reunion, CIRAD Pole Protect Plantes, PVBMT, UMR C53, St Pierre 97410, Reunion.
[Dorge, T.] Tibet Univ, Dept Life Sci, Inst High Mt Anim Ecol, Lhasa 850000, Tibetan AR, Peoples R China.
[Durand, J. D.] ECOLAG, Inst Rech Dev, UMR 5119, Dakar, Senegal.
[Duvernell, D.] So Illinois Univ, Edwardsville, IL 62026 USA.
[Estep, Matt] Univ Georgia, Dept Plant Biol, Athens, GA 30602 USA.
[Fan, Sigang; Hu, Chaoqun; Luo, Peng; Xia, Jianjun; Zhang, Lvping] Chinese Acad Sci, S China Sea Inst Oceanol, Labs Appl Marine Biol & Marine Bioresources Susta, Guangzhou 510301, Peoples R China.
[Fattahi, R.; Jowkar, A.; Kafi, M.] Univ Tehran, Fac Agr, Karaj 3158777871, Iran.
[Villela, Oscar Flores; Gonzalez-Porter, Gracia P.] Univ Nacl Autonoma Mexico, Fac Ciencias, Museo Zool, Mexico City 04510, DF, Mexico.
[Fong, Yokking] Natl Pk Board, Singapore 259569, Singapore.
[Gallardo-Escarate, C.] Univ Concepcion, Ctr Biotecnol, Fac Ciencias Nat & Oceanog, Dept Oceanog, Concepcion, Chile.
[Ganeshaiah, K. N.; Kumar, L. Naveen; Ravikanth, G.; Sumangala, R. C.; Shaanker, R. Uma] Ashoka Trust Res Ecol & Environm, Conservat Genet Lab, Bangalore 560064, Karnataka, India.
[Ganeshaiah, K. N.; Ramesha, B. T.; Ravikanth, G.; Shaanker, R. Uma] Univ Agr Sci, Sch Ecol & Conservat, Bangalore 560065, Karnataka, India.
[Ganeshaiah, K. N.] Univ Agr Sci, Dept Forestry & Environm Sci, Bangalore 560065, Karnataka, India.
[Ghaffari, M. R.; Jowkar, A.; Kermani, M. J.; Mahmoodi, P.; Mardi, M.; Pirseyedi, S. M.; Zeinolabedini, M.] ABRII, Karaj 315351897, Iran.
[Girod, C.; Riera, B.; Sarrazin, E.] CNRS MNHN, UMR 7179, F-91800 Brunoy, France.
[Gomez-Moliner, B. J.; Madeira, M. J.; Sarasola-Puente, V.] Univ Basque Country, Dept Zool & Biol Celular Anim, Vitoria 01006, Spain.
[Gosa, A.; Sarasola-Puente, V.] Aranzadi Soc Sci, Donostia San Sebastian 20014, Spain.
[Govers, F.; Jacobsen, E.] Wageningen Univ, Wageningen, Netherlands.
[Haye, P. A.; Segovia, N. I.] Univ Catolica Norte, Dept Marine Biol, Larrondo 1281, Coquimbo, Chile.
[Haye, P. A.; Segovia, N. I.] CEAZA, Larrondo 1281, Coquimbo, Chile.
[Hoelmer, Kim A.] ARS, USDA, Beneficial Insect Intro Res Unit, Newark, DE 19711 USA.
[Hofmann, S.] Univ Kiel, Inst Clin Mol Biol, D-24105 Kiel, Germany.
[Hong, Yan; Li, Chunhong; Bin Sman, Muhammad Hidayat] Natl Univ Singapore, Temasek Life Sci Lab, Singapore 117604, Singapore.
[Huang, S. W.; Li, Y.] China Acad Agr Sci, Inst Vegetables & Flowers, Beijing, Peoples R China.
[Kim, Hyojoong; Kim, Min-Young; Lee, Seungh-Wan] Seoul Natl Univ, Res Inst Agr & Life Sci, Dept Agr Biotechnol, Seoul 151921, South Korea.
[Kim, Kyung Seok; Lee, Hang] Seoul Natl Univ, Res Inst Vet Sci, Coll Vet Med, Conservat Genome Resource Bank Korean Wildlife, Seoul 151742, South Korea.
[Koita, Ousmane A.] Univ Bamako, Fac Sci & Tech, Lab Appl Mol Biol, Bamako, Mali.
[Korpelainen, H.; Pietilaeinen, M.] Univ Helsinki, Dept Agr Sci, FIN-00014 Helsinki, Finland.
[Leblois, R.; Sarthou, C.] CNRS MNHN, UMR 7205, F-75005 Paris, France.
[Lizana, M.; Sarasola-Puente, V.] Univ Salamanca, Dept Biol Anim, Salamanca 37071, Spain.
[Loughry, W. J.] Valdosta State Univ, Dept Biol, Valdosta, GA 31698 USA.
[Miehe, G.] Philipps Univ Marburg, Dept Geog, D-35032 Marburg, Germany.
[Muth, Peter; Parzies, Heiko K.] Univ Hohenheim, Inst Plant Breeding Seed Sci & Populat Genet, D-70599 Stuttgart, Germany.
[Nacci, D.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Narragansett, RI 02882 USA.
[Pfunder, M.] Ecogen GmbH, CH-8952 Zurich, Switzerland.
[Porta, D.; Porta, J.; Porta, J. M.] AquaSolut Biotech, Malaga 29590, Spain.
[Ramesha, B. T.; Shaanker, R. Uma] Univ Agr Sci, Dept Crop Physiol, Bangalore 560065, Karnataka, India.
[Risterucci, A. M.] CIRAD, UMR 1096, F-34398 Montpellier 5, France.
[Roberts, D. A.; Whitehead, A.] Louisiana State Univ, Baton Rouge, LA 70808 USA.
[Shen, K. N.; Tzeng, W. N.] Natl Taiwan Univ, Inst Fisheries Sci, Taipei 10764, Taiwan.
[Solhoy, T.] Univ Bergen, Dept Zool, N-5020 Bergen, Norway.
[Testa, A.] Univ Naples Federico 2, Sch Biotechnol Sci, Dept Arboriculture Bot & Plant Pathol, Naples, Italy.
[Tollon-Cordet, C.] INRA, UMR DIAPC, F-34060 Montpellier 01, France.
[Van Mourik, Thomas A.; Weltzien, Eva] Int Crops Res Inst Semi Arid Trop, Bamako, Mali.
[Vasudeva, R.] Univ Agr Sci, Coll Forestry, Dept Forest Biol, Sirsi 581401, India.
RP Andree, K (reprint author), IRTA St Carles Rapita, Ctra Poble Nou Km5-5, San Carlos de la Rapita 43540, Spain.
RI Hong, Yan/D-5106-2014; Perry, Annika/F-6784-2014; Andree,
Karl/L-7465-2014; MADEIRA, MARIA JOSE/L-7556-2014; Miehe,
Georg/A-5961-2015; Haye, Pilar/B-7082-2015; Durand,
Jean-Dominique/G-3713-2016; Testa, Antonino/H-6864-2012; Daunt,
Francis/K-6688-2012; Duncan, Neil/B-8906-2013; Govers,
Francine/A-5616-2009; Leung, Kenneth/C-1055-2009; vanderlee,
Theo/J-7296-2013; Axtner, Jan/A-1918-2010; samadi, sarah/G-5011-2010;
Cavers, Stephen/B-7806-2010; Lee, Hang/A-7516-2011; Hailer,
Frank/C-9114-2012; Leblois, Raphael/A-8815-2008; Whitehead,
Andrew/G-2122-2012; CATANESE, GAETANO/A-7510-2009;
OI Hong, Yan/0000-0002-2954-8788; Perry, Annika/0000-0002-7889-7597;
Andree, Karl/0000-0001-6564-0015; MADEIRA, MARIA
JOSE/0000-0002-7357-7228; Haye, Pilar/0000-0002-1093-9076; Durand,
Jean-Dominique/0000-0002-0261-0377; Duvernell,
David/0000-0003-2478-6522; Axtner, Jan/0000-0003-1269-5586; Testa,
Antonino/0000-0003-3983-2448; Daunt, Francis/0000-0003-4638-3388;
Govers, Francine/0000-0001-5311-929X; Cavers,
Stephen/0000-0003-2139-9236; Lee, Hang/0000-0003-0264-6289; Hailer,
Frank/0000-0002-2340-1726; Leblois, Raphael/0000-0002-3051-4497;
CATANESE, GAETANO/0000-0001-6219-4494; Flores-Villela,
Oscar/0000-0002-2849-6912; GOMEZ MOLINER, BENJAMIN
JUAN/0000-0002-3054-8806; Lasso, Eloisa/0000-0003-4586-8674; Jafarkhani
Kermani, Maryam/0000-0002-6013-8314; Knibb, Wayne/0000-0003-2593-0303;
Korpelainen, Helena/0000-0002-7046-6995
NR 0
TC 22
Z9 23
U1 2
U2 46
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1755-098X
J9 MOL ECOL RESOUR
JI Mol. Ecol. Resour.
PD NOV
PY 2010
VL 10
IS 6
BP 1098
EP 1105
DI 10.1111/j.1755-0998.2010.02898.x
PG 8
WC Biochemistry & Molecular Biology; Ecology; Evolutionary Biology
SC Biochemistry & Molecular Biology; Environmental Sciences & Ecology;
Evolutionary Biology
GA 663IJ
UT WOS:000282876300023
PM 21565124
ER
PT J
AU Salinas, K
Hemmer, MJ
Serrano, J
Higgins, L
Anderson, LB
Benninghoff, AD
Williams, DE
Walker, C
AF Salinas, K.
Hemmer, M. J.
Serrano, J.
Higgins, L.
Anderson, L. B.
Benninghoff, A. D.
Williams, D. E.
Walker, C.
TI Identification of Estrogen-Responsive Vitelline Envelope Protein
Fragments From Rainbow Trout (Oncorhynchus mykiss) Plasma Using Mass
Spectrometry
SO MOLECULAR REPRODUCTION AND DEVELOPMENT
LA English
DT Article
ID MOLECULAR-CLONING; GENE-EXPRESSION; MESSENGER-RNA; EGG; FISH; LIVER;
17-BETA-ESTRADIOL; BIOMARKERS; PROTEOMICS; ORGANISMS
AB Plasma peptides previously associated with exposure of juvenile male rainbow trout (Oncorhynchus rnykiss) to the hormone 17 beta-estradiol (E2) were identified using matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS). Specifically, plasma peptides of interest were fractionated and subsequently identified via spectra obtained by MALDI QqTOF MS/MS and LC-MALDI TOFTOF MS/MS analysis, de novo sequencing and database matching. The two peptide masses were identified as significant matches for fragments of the C-terminal propeptides from rainbow trout vitelline envelope protein (VEP)alpha and VEP gamma isoforms. Our findings document the presence of the C-terminal propeptides from rainbow trout VEP alpha and VEP gamma proteins in the bloodstream of juvenile male rainbow trout exposed to E2 via MALDI-TOF-MS detection. We provide three possible explanations for the presence of C-terminal propeptides in the bloodstream, as well as compare previously obtained hepatic transcriptomic results with the plasma proteomic results obtained in the present study.
C1 [Salinas, K.; Hemmer, M. J.] US EPA, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, Gulf Breeze, FL USA.
[Serrano, J.] US EPA, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN USA.
[Higgins, L.; Anderson, L. B.] Univ Minnesota, Dept Biochem Mol Biol & Biophys, Minneapolis, MN USA.
[Benninghoff, A. D.] Utah State Univ, Grad Program Toxicol, Logan, UT 84322 USA.
[Williams, D. E.] Oregon State Univ, Dept Environm & Mol Toxicol, Corvallis, OR 97331 USA.
[Williams, D. E.] Oregon State Univ, Linus Pauling Inst, Corvallis, OR 97331 USA.
[Walker, C.] Natl Marine Fisheries Serv, NOAA, Natl Seafood Inspect Lab, Pascagoula, MS USA.
RP Salinas, K (reprint author), 1 Sabine Isl Dr, Gulf Breeze, FL 32514 USA.
EM salinas.kimberly@epa.gov
FU Marine and Freshwater Biomedical Sciences Center at Oregon State
University; Environmental Health Sciences Center at Oregon State
University; U. S. Environmental Protection Agency; NIH [ES013534,
ES00210, ES003850]; Gulf Ecology Division Marine and Freshwater
Biomedical Sciences Center at Oregon State University
FX The information in this document has been subjected to review by the U.
S. Environmental Protection Agency National Health and Environmental
Effects Research Laboratory and approved for publication. Approval does
not signify that the contents reflect the views of the Agency, nor does
mention of trade names or commercial products constitute endorsement or
recommendation for use. This is contribution number 1360 from the Gulf
Ecology Division. Dr. Benninghoff and Dr. Williams wish to acknowledge
support of the Marine and Freshwater Biomedical Sciences Center and the
Environmental Health Sciences Center at Oregon State University. The
information in this document has been funded wholly (or in part) by the
U. S. Environmental Protection Agency. Dr. Benninghoff and Dr. Williams
wish to acknowledge financial support from NIH grants ES013534, ES00210,
and ES003850.; Supported by the Gulf Ecology Division Marine and
Freshwater Biomedical Sciences Center, the Environmental Health Sciences
Center at Oregon State University and the NIH (grants ES013534, ES00210,
ES003850).
NR 38
TC 0
Z9 0
U1 1
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1040-452X
J9 MOL REPROD DEV
JI Mol. Reprod. Dev.
PD NOV
PY 2010
VL 77
IS 11
BP 963
EP 970
DI 10.1002/mrd.21244
PG 8
WC Biochemistry & Molecular Biology; Cell Biology; Developmental Biology;
Reproductive Biology
SC Biochemistry & Molecular Biology; Cell Biology; Developmental Biology;
Reproductive Biology
GA 692PQ
UT WOS:000285165400005
PM 20939045
ER
PT J
AU Rothman, N
Garcia-Closas, M
Chatterjee, N
Malats, N
Wu, XF
Figueroa, JD
Real, FX
Van den Berg, D
Matullo, G
Baris, D
Thun, M
Kiemeney, LA
Vineis, P
De Vivo, I
Albanes, D
Purdue, MP
Rafnar, T
Hildebrandt, MAT
Kiltie, AE
Cussenot, O
Golka, K
Kumar, R
Taylor, JA
Mayordomo, JI
Jacobs, KB
Kogevinas, M
Hutchinson, A
Wang, ZW
Fu, YP
Prokunina-Olsson, L
Burdett, L
Yeager, M
Wheeler, W
Tardon, A
Serra, C
Carrato, A
Garcia-Closas, R
Lloreta, J
Johnson, A
Schwenn, M
Karagas, MR
Schned, A
Andriole, G
Grubb, R
Black, A
Jacobs, EJ
Diver, WR
Gapstur, SM
Weinstein, SJ
Virtamo, J
Cortessis, VK
Gago-Dominguez, M
Pike, MC
Stern, MC
Yuan, JM
Hunter, DJ
McGrath, M
Dinney, CP
Czerniak, B
Chen, M
Yang, HS
Vermeulen, SH
Aben, KK
Witjes, JA
Makkinje, RR
Sulem, P
Besenbacher, S
Stefansson, K
Riboli, E
Brennan, P
Panico, S
Navarro, C
Allen, NE
Bueno-De-Mesquita, HB
Trichopoulos, D
Caporaso, N
Landi, MT
Canzian, F
Ljungberg, B
Tjonneland, A
Clavel-Chapelon, F
Bishop, DT
Teo, MTW
Knowles, MA
Guarrera, S
Polidoro, S
Ricceri, F
Sacerdote, C
Allione, A
Cancel-Tassin, G
Selinski, S
Hengstler, JG
Dietrich, H
Fletcher, T
Rudnai, P
Gurzau, E
Koppova, K
Bolick, SCE
Godfrey, A
Xu, ZL
Sanz-Velez, JI
Garcia-Prats, MD
Sanchez, M
Valdivia, G
Porru, S
Benhamou, S
Hoover, RN
Fraumeni, JF
Silverman, DT
Chanock, SJ
AF Rothman, Nathaniel
Garcia-Closas, Montserrat
Chatterjee, Nilanjan
Malats, Nuria
Wu, Xifeng
Figueroa, Jonine D.
Real, Francisco X.
Van den Berg, David
Matullo, Giuseppe
Baris, Dalsu
Thun, Michael
Kiemeney, Lambertus A.
Vineis, Paolo
De Vivo, Immaculata
Albanes, Demetrius
Purdue, Mark P.
Rafnar, Thorunn
Hildebrandt, Michelle A. T.
Kiltie, Anne E.
Cussenot, Olivier
Golka, Klaus
Kumar, Rajiv
Taylor, Jack A.
Mayordomo, Jose I.
Jacobs, Kevin B.
Kogevinas, Manolis
Hutchinson, Amy
Wang, Zhaoming
Fu, Yi-Ping
Prokunina-Olsson, Ludmila
Burdett, Laurie
Yeager, Meredith
Wheeler, William
Tardon, Adonina
Serra, Consol
Carrato, Alfredo
Garcia-Closas, Reina
Lloreta, Josep
Johnson, Alison
Schwenn, Molly
Karagas, Margaret R.
Schned, Alan
Andriole, Gerald, Jr.
Grubb, Robert, III
Black, Amanda
Jacobs, Eric J.
Diver, W. Ryan
Gapstur, Susan M.
Weinstein, Stephanie J.
Virtamo, Jarmo
Cortessis, Victoria K.
Gago-Dominguez, Manuela
Pike, Malcolm C.
Stern, Mariana C.
Yuan, Jian-Min
Hunter, David J.
McGrath, Monica
Dinney, Colin P.
Czerniak, Bogdan
Chen, Meng
Yang, Hushan
Vermeulen, Sita H.
Aben, Katja K.
Witjes, J. Alfred
Makkinje, Remco R.
Sulem, Patrick
Besenbacher, Soren
Stefansson, Kari
Riboli, Elio
Brennan, Paul
Panico, Salvatore
Navarro, Carmen
Allen, Naomi E.
Bueno-de-Mesquita, H. Bas
Trichopoulos, Dimitrios
Caporaso, Neil
Landi, Maria Teresa
Canzian, Federico
Ljungberg, Borje
Tjonneland, Anne
Clavel-Chapelon, Francoise
Bishop, David T.
Teo, Mark T. W.
Knowles, Margaret A.
Guarrera, Simonetta
Polidoro, Silvia
Ricceri, Fulvio
Sacerdote, Carlotta
Allione, Alessandra
Cancel-Tassin, Geraldine
Selinski, Silvia
Hengstler, Jan G.
Dietrich, Holger
Fletcher, Tony
Rudnai, Peter
Gurzau, Eugen
Koppova, Kvetoslava
Bolick, Sophia C. E.
Godfrey, Ashley
Xu, Zongli
Sanz-Velez, Jose I.
Garcia-Prats, Maria D.
Sanchez, Manuel
Valdivia, Gabriel
Porru, Stefano
Benhamou, Simone
Hoover, Robert N.
Fraumeni, Joseph F., Jr.
Silverman, Debra T.
Chanock, Stephen J.
TI A multi-stage genome-wide association study of bladder cancer identifies
multiple susceptibility loci
SO NATURE GENETICS
LA English
DT Article
ID CONFERS SUSCEPTIBILITY; UDP-GLUCURONOSYLTRANSFERASES; RECOMBINATION
HOTSPOTS; TELOMERASE MUTATIONS; PULMONARY-FIBROSIS; SEQUENCE VARIANT;
COMMON VARIANTS; CHROMOSOME 8Q24; DOWN-REGULATION; CELL-CARCINOMA
AB We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 x 10(-12)) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 x 10(-11)) on 19q12 maps to CCNE1 and rs11892031 (P = 1 x 10(-7)) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 x 10(-11)) and a tag SNP for NAT2 acetylation status (P = 4 x 10(-11)), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis.
C1 [Rothman, Nathaniel; Garcia-Closas, Montserrat; Chatterjee, Nilanjan; Figueroa, Jonine D.; Baris, Dalsu; Albanes, Demetrius; Purdue, Mark P.; Fu, Yi-Ping; Prokunina-Olsson, Ludmila; Black, Amanda; Weinstein, Stephanie J.; Caporaso, Neil; Landi, Maria Teresa; Hoover, Robert N.; Fraumeni, Joseph F., Jr.; Silverman, Debra T.; Chanock, Stephen J.] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
[Malats, Nuria; Real, Francisco X.] Spanish Natl Canc Res Ctr, Madrid, Spain.
[Wu, Xifeng; Hildebrandt, Michelle A. T.; Chen, Meng; Yang, Hushan] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA.
[Real, Francisco X.] Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Barcelona, Spain.
[Van den Berg, David; Cortessis, Victoria K.; Gago-Dominguez, Manuela; Pike, Malcolm C.; Stern, Mariana C.] Univ So Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90089 USA.
[Matullo, Giuseppe] Univ Turin, Dept Genet Biol & Biochem, Turin, Italy.
[Matullo, Giuseppe; Vineis, Paolo; Guarrera, Simonetta; Polidoro, Silvia; Ricceri, Fulvio; Sacerdote, Carlotta; Allione, Alessandra] Human Genet Fdn HuGeF, Turin, Italy.
[Thun, Michael; Jacobs, Eric J.; Diver, W. Ryan; Gapstur, Susan M.] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.
[Kiemeney, Lambertus A.; Vermeulen, Sita H.; Aben, Katja K.] Radboud Univ Nijmegen Med Ctr, Dept Epidemiol Biostat & Hlth Technol Assessment, Nijmegen, Netherlands.
[Kiemeney, Lambertus A.] Comprehens Canc Ctr E, Nijmegen, Netherlands.
[Kiemeney, Lambertus A.; Witjes, J. Alfred] Radboud Univ Nijmegen Med Ctr, Dept Urol, Nijmegen, Netherlands.
[Vineis, Paolo; Riboli, Elio] Univ London Imperial Coll Sci Technol & Med, London, England.
[De Vivo, Immaculata] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA.
[Rafnar, Thorunn; Sulem, Patrick; Besenbacher, Soren; Stefansson, Kari] DeCODE Genet, Reykjavik, Iceland.
[Kiltie, Anne E.] Univ Oxford, Gray Inst Radiat Oncol & Biol, Oxford, England.
[Cussenot, Olivier] Tenon Hosp, AP HP, Dept Urol, Paris, France.
[Cussenot, Olivier; Cancel-Tassin, Geraldine] Ctr Rech Pathol Prostat, Paris, France.
[Golka, Klaus; Selinski, Silvia; Hengstler, Jan G.] Leibniz Res Ctr Working Environm & Human Factor, Dortmund, Germany.
[Kumar, Rajiv] German Canc Res Ctr, Div Mol Genet Epidemiol, D-6900 Heidelberg, Germany.
[Taylor, Jack A.; Bolick, Sophia C. E.; Godfrey, Ashley; Xu, Zongli] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
[Mayordomo, Jose I.; Sanchez, Manuel; Valdivia, Gabriel] Univ Zaragoza, Zaragoza, Spain.
[Jacobs, Kevin B.; Hutchinson, Amy; Wang, Zhaoming; Burdett, Laurie; Yeager, Meredith] SAIC Frederick Inc, Natl Canc Inst Frederick, Core Genotype Facil, Frederick, MD USA.
[Kogevinas, Manolis] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain.
[Kogevinas, Manolis] Municipal Inst Med Res, Barcelona, Spain.
[Kogevinas, Manolis; Tardon, Adonina; Navarro, Carmen] CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain.
[Kogevinas, Manolis] Natl Sch Publ Hlth, Athens, Greece.
[Wheeler, William] Informat Management Serv Inc, Rockville, MD USA.
[Tardon, Adonina] Univ Oviedo, Inst Univ Oncol, Oviedo, Spain.
[Carrato, Alfredo] Ramon & Cajal Univ Hosp, Madrid, Spain.
[Garcia-Closas, Reina] Hosp Univ Canarias, Unidad Invest, San Cristobal la Laguna, Spain.
[Lloreta, Josep] Univ Pompeu Fabra, Hosp Mar Inst Municipal Invest Med IMIM, Barcelona, Spain.
[Johnson, Alison] Vermont Canc Registry, Burlington, VT USA.
[Schwenn, Molly] Maine Canc Registry, Augusta, ME USA.
[Karagas, Margaret R.; Schned, Alan] Dartmouth Med Sch, Hanover, NH USA.
[Andriole, Gerald, Jr.; Grubb, Robert, III] Washington Univ, Sch Med, Dept Urol, St Louis, MO USA.
[Virtamo, Jarmo] Natl Inst Hlth & Welf, Helsinki, Finland.
[Pike, Malcolm C.] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA.
[Yuan, Jian-Min] Univ Minnesota, Mason Canc Ctr, Minneapolis, MN USA.
[Hunter, David J.; McGrath, Monica] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Program Mol & Genet Epidemiol, Boston, MA 02115 USA.
[Dinney, Colin P.] Univ Texas MD Anderson Canc Ctr, Dept Urol, Houston, TX 77030 USA.
[Czerniak, Bogdan] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA.
[Vermeulen, Sita H.; Makkinje, Remco R.] Radboud Univ Nijmegen Med Ctr, Dept Human Genet, Nijmegen, Netherlands.
[Stefansson, Kari] Univ Iceland, Fac Med, Reykjavik, Iceland.
[Brennan, Paul] Int Agcy Res Canc, Lyon, France.
[Panico, Salvatore] Univ Naples Federico 2, Dept Clin & Expt Med, Naples, Italy.
[Navarro, Carmen] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain.
[Allen, Naomi E.] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England.
[Bueno-de-Mesquita, H. Bas] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands.
[Trichopoulos, Dimitrios] Acad Athens, Bur Epidemiol Res, Athens, Greece.
[Canzian, Federico] German Canc Res Ctr, Genom Epidemiol Grp, Heidelberg, Germany.
[Ljungberg, Borje] Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden.
[Tjonneland, Anne] Inst Canc Epidemiol, Danish Canc Soc, Copenhagen, Denmark.
[Clavel-Chapelon, Francoise] Paris S Univ, Inst Gustave Roussy, Ctr Res Epidemiol & Populat Hlth, Villejuif, France.
[Bishop, David T.; Teo, Mark T. W.; Knowles, Margaret A.] Univ Leeds, St Jamess Univ Hosp, Leeds Inst Mol Med, Leeds, W Yorkshire, England.
[Sacerdote, Carlotta] Univ Turin, Canc Epidemiol Unit, Turin, Italy.
[Dietrich, Holger] Paul Gerhardt Fdn, Dept Urol, Wittenberg, Germany.
[Fletcher, Tony] Inst Hyg & Trop Med, London, England.
[Rudnai, Peter] Natl Inst Environm Hlth, Budapest, Hungary.
[Gurzau, Eugen] Univ Babes Bolyai, Ctr Environm Hlth, R-3400 Cluj Napoca, Romania.
[Koppova, Kvetoslava] State Hlth Inst, Banska Bystrica, Slovakia.
[Sanz-Velez, Jose I.; Garcia-Prats, Maria D.] San Jorge Univ Hosp, Huesca, Spain.
[Porru, Stefano] Univ Brescia, Sect Occupat Med & Ind Hyg, Dept Expt & Appl Med, Brescia, Italy.
[Benhamou, Simone] CEPH, Fdn Jean Dausset, U946, INSERM, Paris, France.
[Benhamou, Simone] Inst Gustave Roussy, UMR8200, CNRS, Villejuif, France.
RP Garcia-Closas, M (reprint author), NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
EM montse.garciaclosas@icr.ac.uk
RI Mayordomo, Jose/K-3453-2013; Hengstler, Jan/O-1415-2013; Witjes,
Fred/N-9665-2013; Kiemeney, Lambertus/D-3357-2009; Albanes,
Demetrius/B-9749-2015; Garcia-Closas, Montserrat /F-3871-2015; Malats,
Nuria/H-7041-2015; Makkinje, Remco/Q-2406-2015; Serra, C/E-6879-2014;
Clavel-Chapelon, Francoise/G-6733-2014; Lloreta, J/I-2112-2014; Purdue,
Mark/C-9228-2016; Vermeulen, H.H.M./L-4716-2015; Aben,
Katja/G-9686-2016; Benhamou, Simone/K-6554-2015; Matullo,
Giuseppe/K-6383-2016; Panico, Salvatore/K-6506-2016; Kogevinas,
Manolis/C-3918-2017; Real, Francisco X/H-5275-2015;
OI Kiemeney, Lambertus/0000-0002-2368-1326; Garcia-Closas, Montserrat
/0000-0003-1033-2650; Malats, Nuria/0000-0003-2538-3784; Serra,
C/0000-0001-8337-8356; Lloreta, J/0000-0003-1644-9470; MATULLO,
Giuseppe/0000-0003-0674-7757; Yuan, Jian-Min/0000-0002-4620-3108;
Sacerdote, Carlotta/0000-0002-8008-5096; xu, zongli/0000-0002-9034-8902;
Bishop, Tim/0000-0002-8752-8785; taylor, jack/0000-0001-5303-6398;
Besenbacher, Soren/0000-0003-1455-1738; Cancel-Tassin,
Geraldine/0000-0002-9583-6382; Purdue, Mark/0000-0003-1177-3108; Aben,
Katja/0000-0002-0214-2147; Panico, Salvatore/0000-0002-5498-8312; Kumar,
Rajiv/0000-0002-6093-0395; Kiltie, Anne/0000-0001-7208-2912;
Prokunina-Olsson, Ludmila/0000-0002-9622-2091; Real, Francisco
X/0000-0001-9501-498X; Allione, Alessandra/0000-0001-9599-309X
FU National Cancer Institute, US National Institutes of Health
[HHSN261200800001E]
FX This project has been funded in part with federal funds from the
National Cancer Institute, US National Institutes of Health, under
Contract No. HHSN261200800001E. The content of this publication does not
necessarily reflect the views or policies of the Department of Health
and Human Services, nor does mention of trade names, commercial products
or organizations imply endorsement by the US Government.
NR 52
TC 214
Z9 221
U1 1
U2 43
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1061-4036
J9 NAT GENET
JI Nature Genet.
PD NOV
PY 2010
VL 42
IS 11
BP 978
EP U98
DI 10.1038/ng.687
PG 9
WC Genetics & Heredity
SC Genetics & Heredity
GA 671VW
UT WOS:000283540500015
PM 20972438
ER
PT J
AU Beasley, TE
Evansky, PA
Gilbert, ME
Bushnell, PJ
AF Beasley, Tracey E.
Evansky, Paul A.
Gilbert, Mary E.
Bushnell, Philip J.
TI Behavioral effects of subchronic inhalation of toluene in adult rats
SO NEUROTOXICOLOGY AND TERATOLOGY
LA English
DT Article
DE Organic solvent; Signal detection; Fear conditioning; Motor activity;
Quinpirole; Raclopride
ID MEDIATED LOCOMOTOR-ACTIVITY; ORGANIC-SOLVENTS; COLOR-VISION; 40 PPM;
AGONIST BINDING; EXPOSURE; PERSISTENT; TASK; ATTENTION; ABUSE
AB Whereas the acute neurobehavioral effects of toluene are robust and well characterized, evidence for persistent effects of repeated exposure to this industrial solvent is less compelling. The present experiment sought to determine whether subchronic inhalation of toluene caused persistent behavioral changes in rats. Adult male Long-Evans rats inhaled toluene vapor (0, 10, 100, or 1000 ppm) for 6 h/day, 5 days/week for 13 weeks and were evaluated on a series of behavioral tests beginning 3 days after the end of exposure. Toluene delayed appetitively-motivated acquisition of a lever-press response, but did not affect motor activity, anxiety-related behavior in the elevated plus maze, trace fear conditioning, acquisition of an appetitively-motivated visual discrimination, or performance of a visual signal detection task Challenges with acute inhalation of toluene vapor (1200-2400 ppm for 1 h) and injections of quinpirole (0.01-0.03 mg/kg) and raclopride (0.03-0.10 mg/kg) revealed no toluene-induced latent impairments in visual signal detection. These results are consistent with a pattern of subtle and inconsistent long-term effects of daily exposure to toluene vapor, in contrast to robust and reliable effects of acute inhalation of the solvent. Published by Elsevier Inc.
C1 [Beasley, Tracey E.; Gilbert, Mary E.; Bushnell, Philip J.] US EPA, Natl Hlth & Environm Effects Res Lab, Toxicol Assessment Div, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Evansky, Paul A.] US EPA, Natl Hlth & Environm Effects Res Lab, Environm Publ Hlth Div, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Bushnell, PJ (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Toxicol Assessment Div, Off Res & Dev, MD B105-04, Res Triangle Pk, NC 27711 USA.
EM bushnell.philip@epa.gov
NR 51
TC 6
Z9 7
U1 0
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0892-0362
EI 1872-9738
J9 NEUROTOXICOL TERATOL
JI Neurotoxicol. Teratol.
PD NOV-DEC
PY 2010
VL 32
IS 6
BP 611
EP 619
DI 10.1016/j.ntt.2010.05.005
PG 9
WC Neurosciences; Toxicology
SC Neurosciences & Neurology; Toxicology
GA 692BY
UT WOS:000285127700005
PM 20580818
ER
PT J
AU Duke, TJ
Jahed, NC
Veneroso, CC
Da Roza, R
Johnson, O
Hoffman, D
Barsky, SH
Levine, PH
AF Duke, Tina J.
Jahed, Nasreen C.
Veneroso, Carmela C.
Da Roza, Ricardo
Johnson, Owen
Hoffman, Daniel
Barsky, Sanford H.
Levine, Paul H.
TI A cluster of inflammatory breast cancer (IBC) in an office setting:
Additional evidence of the importance of environmental factors in IBC
etiology
SO ONCOLOGY REPORTS
LA English
DT Article
DE inflammatory breast cancer; environmental factors; oral contraceptives;
hormone replacement therapy
ID ORAL-CONTRACEPTIVE USE; END RESULTS PROGRAM; MAGNETIC-FIELDS;
UNITED-STATES; OCCUPATIONAL EXPOSURES; CARCINOMA INCIDENCE; E-CADHERIN;
BODY SIZE; WOMEN; RISK
AB We investigated a cluster of three cases of inflammatory breast cancer (IBC) diagnosed within 10 months in an office setting of 24 people. Information about medical history, pregnancy history, family history of breast cancer, oral contraceptive use/hormone replacement therapy, exposure to possible oncogenic agents and tumor promoters were obtained to determine whether there were differences in risk factors for IBC between cases and controls. The physical environment and location of the cases' office raised concern about air and water quality as well as radiation as being contributory risk factors for developing IBC. Of the three women with IBC, two had high exposures to pesticides/herbicides, all three used oral contraceptives and two used hormone replacement therapy at the time of diagnosis, two had a family history of breast cancer, and two were obese. Among fifteen controls four had pesticide/herbicide exposure, one had a family history of breast cancer, nine used oral contraceptives, seven used hormone replacement therapy, and five were obese. No specific environmental causes were established for this cluster. Several promoting factors have been suggested that could result in subclinical breast cancer emerging as IBC. Among them are exogenous hormones and exposure to herbicides/pesticides.
C1 [Duke, Tina J.] US EPA, Off Water, Washington, DC 20460 USA.
[Barsky, Sanford H.] Ohio State Univ, Ctr Comprehens Canc, Dept Pathol, Columbus, OH 43210 USA.
[Johnson, Owen] Ohio State Univ, Inflammatory Breast Canc Fdn, Ctr Comprehens Canc, Columbus, OH 43210 USA.
[Da Roza, Ricardo] Ohio State Univ, Ctr Comprehens Canc, Eden Valley Med Ctr, Columbus, OH 43210 USA.
[Jahed, Nasreen C.; Veneroso, Carmela C.; Hoffman, Daniel; Levine, Paul H.] George Washington Univ, Sch Publ Hlth & Hlth Serv, Dept Epidemiol & Biostat, Washington, DC 20037 USA.
RP Levine, PH (reprint author), George Washington Univ, Sch Publ Hlth & Hlth Serv, Dept Epidemiol & Biostat, 2100-W Penn Ave NW,Suite 817, Washington, DC 20037 USA.
EM sphphl@gwumc.edu
FU Department of Defense [DAMD 17-01-1-0244]; Inflammatory Breast Cancer
Research Foundation
FX We thank Ms. Barbara Severini who was instrumental in facilitating
collection of environmental data and recruitment of controls. We also
would like to thank all of the study participants and funding agencies
for contributing to the work of this study. The opinions in this
manuscript are those of the authors and do not necessarily represent the
opinions and/or policies of the U.S. Environmental Protection Agency.
Supported in part by Grant no. DAMD 17-01-1-0244 with the Department of
Defense and the Inflammatory Breast Cancer Research Foundation.
NR 42
TC 5
Z9 5
U1 1
U2 6
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1021-335X
J9 ONCOL REP
JI Oncol. Rep.
PD NOV
PY 2010
VL 24
IS 5
BP 1277
EP 1284
DI 10.3892/or_00000983
PG 8
WC Oncology
SC Oncology
GA 666JX
UT WOS:000283112200022
PM 20878121
ER
PT J
AU Cooper, GS
Wither, J
Bernatsky, S
Claudio, JO
Clarke, A
Rioux, JD
Fortin, PR
AF Cooper, Glinda S.
Wither, Joan
Bernatsky, Sasha
Claudio, Jaime O.
Clarke, Ann
Rioux, John D.
Fortin, Paul R.
CA CaNIOS GenES Investigators
TI Occupational and environmental exposures and risk of systemic lupus
erythematosus: silica, sunlight, solvents
SO RHEUMATOLOGY
LA English
DT Article
DE Systemic lupus erythematosus; Risk factors; Silica; Ultraviolet
radiation; Solvents; Occupation; Environment
ID ANTI-DNA SPECIFICITY; TIME SPENT OUTDOORS; AUTOREACTIVE RESPONSES;
CRYSTALLINE SILICA; AUTOIMMUNE-DISEASE; T-CELLS; PHTHALATE; WORKERS;
AGREEMENT
AB Methods. SLE cases (n = 258) were recruited from 11 rheumatology centres across Canada. Controls (without SLE, n = 263) were randomly selected from phone number listings and matched to cases by age, sex and area of residence. Data were collected using a structured telephone interview.
Results. An association was seen with outdoor work in the 12 months preceding diagnosis [odds ratio (OR) 2.0; 95% CI 1.1, 3.8]; effect modification by sun reaction was suggested, with the strongest effect among people who reported reacting to midday sun with a blistering sunburn or a rash (OR 7.9; 95% CI 0.97, 64.7). Relatively strong but imprecise associations were seen with work as an artist working with paints, dyes or developing film (OR 3.9; 95% CI 1.3, 12.3) and work that included applying nail polish or nail applications (OR 10.2; 95% CI 1.3, 81.5). Patients were more likely than controls to report participation in pottery or ceramics work as a leisure activity, with an increased risk among individuals with a total frequency of at least 26 days (OR 2.1; 95% CI 1.1, 3.9). Analyses of potential respirable silica exposures suggested an exposure-response gradient (OR 1.0, 1.4. and 2.1 for zero, one and two or more sources of exposure, respectively; trend test P < 0.01).
Conclusions. This study supports the role of specific occupational and non-occupational exposures in the development of SLE.
C1 [Cooper, Glinda S.] George Washington Univ, Dept Environm & Occupat Hlth, Sch Publ Hlth & Hlth Serv, Washington, DC USA.
[Cooper, Glinda S.] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
[Wither, Joan] Toronto Western Hosp, Dept Rheumatol, Toronto, ON M5T 2S8, Canada.
[Bernatsky, Sasha; Clarke, Ann] McGill Univ, Dept Med, Ctr Hlth, Montreal, PQ, Canada.
[Claudio, Jaime O.; Fortin, Paul R.] Univ Hlth Network, Toronto Western Hosp, Toronto, ON, Canada.
[Rioux, John D.] Univ Toronto, Toronto Western Hosp, Lab Genet & Med Genom Inflammat, Toronto, ON M5T 2S8, Canada.
RP Cooper, GS (reprint author), US EPA, Natl Ctr Environm Assessment 8601P, 1200 Penn Ave NW, Washington, DC 20460 USA.
EM cooper.glinda@epa.gov
RI Rioux, John/A-9599-2015; Pope, Janet/G-3342-2011;
OI Rioux, John/0000-0001-7560-8326; Peschken, Christine/0000-0002-4269-5213
FU Arthritis Centre of Excellence; University of Toronto; Lupus Canada;
Lupus Ontario; Lupus Foundation of Ontario; BC Lupus; Arthritis and
Autoimmune Research Centre Foundation; McGill University, Department of
Medicine and Research Institute; Singer Family Fund for Lupus Research;
Canadian Institutes of Health Research [62840]; National Institute of
Environmental Health Sciences, National Institutes of Health
FX P.R.F. is a Distinguished Senior Investigator of The Arthritis Society
with additional support from the Arthritis Centre of Excellence,
University of Toronto. He is one of the Centre Directors of the Lupus
Clinical Trial Consortium. CaNIOS is supported in part by Lupus Canada,
Lupus Ontario, the Lupus Foundation of Ontario and BC Lupus as well as
by the Arthritis and Autoimmune Research Centre Foundation. J.W. is
supported by the Arthritis Centre of Excellence. Much of G.S.C.'s work
on this project was conducted while at the National Institute of
Environmental Health Sciences. The views expressed in this article are
those of the authors and do not necessarily reflect the views or
policies of the US Environmental Protection Agency. S.B. is a Canadian
Institutes of Health Research Junior Investigator and Canadian Arthritis
Network Scholar and is supported by the McGill University, Department of
Medicine and Research Institute. A.C. is a National Scholar of the Fonds
de la Recherche en Sante du Quebec, and co-director of the McGill
University Health Centre Lupus Clinic, which is supported by the Singer
Family Fund for Lupus Research.; This study is funded by the Canadian
Institutes of Health Research Grant No 62840. This work was supported by
the Intramural Research Program of the National Institute of
Environmental Health Sciences, National Institutes of Health.
NR 29
TC 48
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U1 1
U2 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1462-0324
J9 RHEUMATOLOGY
JI RHEUMATOLOGY
PD NOV
PY 2010
VL 49
IS 11
BP 2172
EP 2180
DI 10.1093/rheumatology/keq214
PG 9
WC Rheumatology
SC Rheumatology
GA 666MU
UT WOS:000283120300025
PM 20675707
ER
PT J
AU Gerke, TL
Scheckel, KG
Maynard, JB
AF Gerke, Tammie L.
Scheckel, Kirk G.
Maynard, J. Barry
TI Speciation and distribution of vanadium in drinking water iron pipe
corrosion by-products
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Iron; V K-eddge; Pb L3-edge; mu-XRF; mu-XANES spectroscopy; Corrosion
ID DISTRIBUTION-SYSTEMS; RELEASE; SCALES; MODEL; STEEL; SPECTROSCOPY;
TUBERCLES; SURFACE; GROWTH; PH
AB Vanadium (V) when ingested from drinking water in high concentrations (>15 mu g L(-1)) is a potential health risk and is on track to becoming a regulated contaminant High concentrations of V have been documented in lead corrosion by-products as Pb(5)(V(5+)O(4))(3)Cl (vanadinite) which. In natural deposits is associated with iron oxides/oxyhydroxides, phases common in iron pipe corrosion by-products The extent of potential reservoirs of V in iron corrosion by-products, its speciation. and mechanism of inclusion however are unknown The aim of this study is to assess these parameters in non corrosion by-products, implementing synchrotron-based mu-XRF mapping and mu-XANES along with traditional physiochemical characterization The morphologies, mineralogies, and chemistry of the samples studied are superficially similar to typical iron corrosion by-products. However, we found V present as discrete grains of Pb(5)(V(5+)O(4))(3)Cl likely embedded in the surface regions of the iron corrosion by-products Concentrations of V observed in bulk XRF analysis ranged from 35 to 899 mg kg(-1). We calculate that even in pipes with iron corrosion by-products with low V concentration, 100 mg kg(-1), as little as 0 0027% of a 0.1-cm thick X 100-cm long section of that corrosion by-product needs to be disturbed to increase V concentrations in the drinking water at the tap to levels well above the 15 mu g L(-1) notification level set by the State of California and could adversely impact human health. In addition, It is likely that large reservoirs of V are associated with iron corrosion by-products in unlined cast iron mains and service branches in numerous drinking water distribution systems (C) 2010 Elsevier B.V All rights reserved.
C1 [Gerke, Tammie L.; Maynard, J. Barry] Univ Cincinnati, Dept Geol, Cincinnati, OH 45221 USA.
[Scheckel, Kirk G.] US EPA, ORD, NRMRL, LRPCD, Cincinnati, OH 45268 USA.
RP Gerke, TL (reprint author), Univ Cincinnati, Dept Geol, Cincinnati, OH 45221 USA.
RI Scheckel, Kirk/C-3082-2009
OI Scheckel, Kirk/0000-0001-9326-9241
FU NSERC; University of Washington; Simon Fraser University; Advanced
Photon Source; U.S Department of Energy, Office of Science, Office of
Basic Energy Sciences [DE-AC02-06CH11357]; U.S. Environmental Protection
Agency through Office of Research and Development
FX PNC/XOR facilities at the Advanced Photon Source, and research at these
facilities, are supported by the U.S Department of Energy, Basic Energy
Sciences, a major facilities access grant from NSERC, the University of
Washington, Simon Fraser University and the Advanced Photon Source. Use
of the Advanced Photon Source is also supported by the U.S Department of
Energy, Office of Science, Office of Basic Energy Sciences, under
Contract DE-AC02-06CH11357. The U.S. Environmental Protection Agency,
through its Office of Research and Development, contributed to the
research described here. It has not been subject to Agency review and,
therefore, does not necessarily reflect the views of the Agency. Mention
of trade names of commercial products and companies does not constitute
endorsement or recommendation for use We would like to thank M. K.
DeSantis and Jason Dorch for photographs of the iron corrosion
by-products, Dr. Steve Held for use of his personal macros used in
portions of the data processing, and Dr. Robert Gordon for providing
some standard material for the V K-edge mu-XANES analysis. We would also
like to thank Scott A. Walley for his edits and two anonymous reviewers
for their insightful comments all of which greatly improved the
manuscript.
NR 34
TC 20
Z9 21
U1 2
U2 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0048-9697
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD NOV 1
PY 2010
VL 408
IS 23
BP 5845
EP 5853
DI 10.1016/j.scitotenv.2010.08.036
PG 9
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 691HK
UT WOS:000285070700028
PM 20863549
ER
PT J
AU Hornung, MW
Degitz, SJ
Korte, LM
Olson, JM
Kosian, PA
Linnum, AL
Tietge, JE
AF Hornung, Michael W.
Degitz, Sigmund J.
Korte, Lisa M.
Olson, Jessica M.
Kosian, Patricia A.
Linnum, Ann L.
Tietge, Joseph E.
TI Inhibition of Thyroid Hormone Release from Cultured Amphibian Thyroid
Glands by Methimazole, 6-Propylthiouracil, and Perchlorate
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE thyroid hormone; Xenopus laevis; tissue culture; methimazole;
perchlorate; 6-propylthiouracil
ID XENOPUS-LAEVIS; IN-VITRO; CELL PROLIFERATION; THYROTROPIN; PEROXIDASE;
TSH; METAMORPHOSIS; DISRUPTORS; CHEMICALS; RESPONSES
AB Thyroid gland explant cultures from prometamorphic Xenopus laevis tadpoles were evaluated for their utility in assessing chemicals for thyroid hormone (TH) synthesis disruption. The response of cultured thyroid glands to bovine thyroid stimulating hormone (bTSH) and the TH synthesis inhibitors methimazole, 6-propylthiouracil, and perchlorate was determined. Thyroid glands continuously exposed for 12 days to graded concentrations of bTSH released thyroxine (T4) in a dose-dependent manner. Over time, the glands appeared to reach a constant daily rate of T4 release. This suggested that the T4 stores in the glands were initially depleted but continuous release was maintained by synthesis of new hormone. The potency of methimazole, 6-propylthiouracil, and perchlorate for inhibiting T4 release was determined using glands cotreated with a single maximally effective bTSH concentration and graded concentrations of chemical. Inhibition of T4 release was dose dependent for all three chemicals. Perchlorate was the most potent inhibitor of T4 release. Methimazole and 6-propylthiouracil exhibited lower potency than perchlorate but similar potency to each other. The IC50 (mean +/- SD) for inhibition of T4 release by the thyroid glands was 1.2 +/- 0.55, 8.6 +/- 1.3, and 13 +/- 4.0 mu M for perchlorate, 6-propylthiouracil, and methimazole, respectively. This model system shows promise as a tool to evaluate the potency of chemicals that inhibit T4 release from thyroid glands and may be predictive of in vivo T4 synthesis inhibition in prometamorphic tadpoles.
C1 [Hornung, Michael W.; Degitz, Sigmund J.; Kosian, Patricia A.; Linnum, Ann L.; Tietge, Joseph E.] US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Duluth, MN 55803 USA.
[Korte, Lisa M.; Olson, Jessica M.] Student Contractor Serv, Duluth, MN 55804 USA.
RP Hornung, MW (reprint author), US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, 6201 Congdon Blvd, Duluth, MN 55803 USA.
EM hornung.michael@epa.gov
NR 35
TC 12
Z9 13
U1 4
U2 17
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD NOV
PY 2010
VL 118
IS 1
BP 42
EP 51
DI 10.1093/toxsci/kfq166
PG 10
WC Toxicology
SC Toxicology
GA 666DN
UT WOS:000283092200007
PM 20530234
ER
PT J
AU DiMaggio, PA
Subramani, A
Judson, RS
Floudas, CA
AF DiMaggio, Peter A., Jr.
Subramani, Ashwin
Judson, Richard S.
Floudas, Christodoulos A.
TI A Novel Framework for Predicting In Vivo Toxicities from In Vitro Data
Using Optimal Methods for Dense and Sparse Matrix Reordering and
Logistic Regression
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE environmental toxicology; in vitro and alternatives; biclustering;
integer linear optimization
ID MOLECULAR DISCOVERY; MICROARRAY DATA; 200 PESTICIDES; CHEMICALS; GENES;
CELLS
AB In this work, we combine the strengths of mixed-integer linear optimization (MILP) and logistic regression for predicting the in vivo toxicity of chemicals using only their measured in vitro assay data. The proposed approach utilizes a biclustering method based on iterative optimal reordering (DiMaggio, P. A., McAllister, S. R., Floudas, C. A., Feng, X. J., Rabinowitz, J. D., and Rabitz, H. A. (2008). Biclustering via optimal re-ordering of data matrices in systems biology: rigorous methods and comparative studies. BMC Bioinformatics 9, 458-474.; DiMaggio, P. A., McAllister, S. R., Floudas, C. A., Feng, X. J., Rabinowitz, J. D., and Rabitz, H. A. (2010b). A network flow model for biclustering via optimal re-ordering of data matrices. J. Global. Optim. 47, 343-354.) to identify biclusters corresponding to subsets of chemicals that have similar responses over distinct subsets of the in vitro assays. The biclustering of the in vitro assays is shown to result in significant clustering based on assay target (e.g., cytochrome P450 [CYP] and nuclear receptors) and type (e.g., downregulated BioMAP and biochemical high-throughput screening protein kinase activity assays). An optimal method based on mixed-integer linear optimization for reordering sparse data matrices (DiMaggio, P. A., McAllister, S. R., Floudas, C. A., Feng, X. J., Li, G. Y., Rabinowitz, J. D., and Rabitz, H. A. (2010a). Enhancing molecular discovery using descriptor-free rearrangement clustering techniques for sparse data sets. AIChE J. 56, 405-418.; McAllister, S. R., DiMaggio, P. A., and Floudas, C. A. (2009). Mathematical modeling and efficient optimization methods for the distance-dependent rearrangement clustering problem. J. Global. Optim. 45, 111-129) is then applied to the in vivo data set (21.7% sparse) in order to cluster end points that have similar lowest effect level (LEL) values, where it is observed that the end points are effectively clustered according to (1) animal species (i.e., the chronic mouse and chronic rat end points were clearly separated) and (2) similar physiological attributes (i.e., liver- and reproductive-related end points were found to separately cluster together). As the liver and reproductive end points exhibited the largest degree of correlation, we further analyzed them using regularized logistic regression in a rank-and-drop framework to identify which subset of in vitro features could be utilized for in vivo toxicity prediction. It was observed that the in vivo end points that had similar LEL responses over the 309 chemicals (as determined by the sparse clustering results) also shared a significant subset of selected in vitro descriptors. Comparing the significant descriptors between the two different categories of end points revealed a specificity of the CYP assays for the liver end points and preferential selection of the estrogen/androgen nuclear receptors by the reproductive end points.
C1 [DiMaggio, Peter A., Jr.; Subramani, Ashwin; Floudas, Christodoulos A.] Princeton Univ, Dept Chem & Biol Engn, Princeton, NJ 08544 USA.
[Judson, Richard S.] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Floudas, CA (reprint author), Princeton Univ, Dept Chem & Biol Engn, Princeton, NJ 08544 USA.
EM floudas@titan.princeton.edu
OI DiMaggio, Peter/0000-0003-1996-0813; Judson, Richard/0000-0002-2348-9633
FU National Institutes of Health [R01LM009338]; U.S. Environmental
Protection Agency, EPA [R 832721-010]
FX National Institutes of Health (R01LM009338 to C.A.F.); U.S.
Environmental Protection Agency, EPA (R 832721-010 to C.A.F.).
NR 25
TC 9
Z9 9
U1 1
U2 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
J9 TOXICOL SCI
JI Toxicol. Sci.
PD NOV
PY 2010
VL 118
IS 1
BP 251
EP 265
DI 10.1093/toxsci/kfq233
PG 15
WC Toxicology
SC Toxicology
GA 666DN
UT WOS:000283092200026
PM 20702588
ER
PT J
AU Jain, P
Townsend, TG
Tolaymat, TM
AF Jain, Pradeep
Townsend, Timothy G.
Tolaymat, Thabet M.
TI Steady-state design of vertical wells for liquids addition at bioreactor
landfills
SO WASTE MANAGEMENT
LA English
DT Article
ID MUNICIPAL SOLID-WASTE
AB The rate at which liquids can be added to a vertical well, the lateral zone of impact of the well, and the liquids volume needed to wet the waste within the zone of impact of the well are the key inputs needed to design a vertical well system. This paper presents design charts that can be used to estimate these inputs as a function of municipal solid waste properties (porosity, hydraulic conductivity, and anisotropy ratio), well dimensions (radius and screen length), and injection pressure. SEEP/W modeling was conducted to estimate the key design inputs for a range of conditions practically encountered for a vertical well installed in landfilled waste. The flow rate, lateral zone of impact of a well, liquids volume added, and injection pressure were normalized with the waste properties and well dimensions to formulate dimensionless variables. A series of design charts were created to present dimensionless steady-state flow rate, lateral zone of impact, and the dimensionless liquid volume needed to reach a steady-state condition, as a function of dimensionless input variables. By using dimensionless variables formulated for this work, these charts permit the user to estimate the steady-state design variables described above for a wide range of configurations and conditions beyond those simulated without the need for further modeling. The results of the study suggest that the lateral extent of the well can be estimated using Darcy's equation and assuming saturated unit-gradient vertical flow regime below the well bottom. An example problem is presented to illustrate the use of the design charts. The scenario described in the example problem was also modeled with SEEP/W, and the results were compared with those obtained from the design charts to demonstrate the validity of design charts for scenarios other than those used for the development of the design charts. The methodology presented in this paper should be thought of as a means to provide a set of bounds that an engineer can use along with their judgment in the design of a system for a specific site. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Townsend, Timothy G.] Univ Florida, Dept Environm Engn Sci, Gainesville, FL 32611 USA.
[Jain, Pradeep] Innovat Waste Consulting Serv LLC, Gainesville, FL 32605 USA.
[Tolaymat, Thabet M.] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA.
RP Townsend, TG (reprint author), Univ Florida, Dept Environm Engn Sci, POB 116450, Gainesville, FL 32611 USA.
EM pjain@iwcs.biz; ttown@ufl.edu; tolaymat.thabet@epa.gov
RI Townsend, Timothy/D-1981-2009
OI Townsend, Timothy/0000-0002-1222-0954
FU The US Environmental Protection Agency through its Office of Research
and Development [EP05C000550]
FX The US Environmental Protection Agency through its Office of Research
and Development funded and managed the research described here under
purchase order number: EP05C000550 to Innovative Waste Consulting
Services, LLC. Mention of trade names or commercial products does not
constitute endorsement or recommendation for use. The scientific views
expressed are solely those of the authors and do not necessarily reflect
those of the US EPA.
NR 26
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U1 2
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0956-053X
J9 WASTE MANAGE
JI Waste Manage.
PD NOV
PY 2010
VL 30
IS 11
BP 2022
EP 2029
DI 10.1016/j.wasman.2010.02.020
PG 8
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 674OD
UT WOS:000283755700002
PM 20304622
ER
PT J
AU Cochran, KM
Townsend, TG
AF Cochran, K. M.
Townsend, T. G.
TI Estimating construction and demolition debris generation using a
materials flow analysis approach
SO WASTE MANAGEMENT
LA English
DT Article
ID LIFE-CYCLE; ENERGY; WASTE
AB The magnitude and composition of a region's construction and demolition (C&D) debris should be under-stood when developing rules, policies and strategies for managing this segment of the solid waste stream. In the US, several national estimates have been conducted using a weight-per-construction-area approximation; national estimates using alternative procedures such as those used for other segments of the solid waste stream have not been reported for C&D debris. This paper presents an evaluation of a materials flow analysis (MFA) approach for estimating C&D debris generation and composition for a large region (the US). The consumption of construction materials in the US and typical waste factors used for construction materials purchasing were used to estimate the mass of solid waste generated as a result of construction activities. Debris from demolition activities was predicted from various historical construction materials consumption data and estimates of average service lives of the materials. The MFA approach estimated that approximately 610-780 x 10(6) Mg of C&D debris was generated in 2002. This predicted mass exceeds previous estimates using other C&D debris predictive methodologies and reflects the large waste stream that exists. Published by Elsevier Ltd.
C1 [Cochran, K. M.] US EPA, Off Resource Conservat & Recovery, Washington, DC 20460 USA.
[Townsend, T. G.] Univ Florida, Dept Environm Engn Sci, Gainesville, FL 32611 USA.
RP Cochran, KM (reprint author), US EPA, Off Resource Conservat & Recovery, 1200 Pennsylvania Ave NW,Mailcode 5306P, Washington, DC 20460 USA.
EM Cochran.Kimberly@epa.gov
RI Townsend, Timothy/D-1981-2009
OI Townsend, Timothy/0000-0002-1222-0954
FU Hinkley Center of Solid and Hazardous Waste Management; Florida
Department of Environmental Protection,; Clay County, Florida
FX The authors would like to acknowledge the Hinkley Center of Solid and
Hazardous Waste Management, the Florida Department of Environmental
Protection, and Clay County, Florida for their support of this research.
NR 38
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U1 2
U2 35
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0956-053X
J9 WASTE MANAGE
JI Waste Manage.
PD NOV
PY 2010
VL 30
IS 11
BP 2247
EP 2254
DI 10.1016/j.wasman.2010.04.008
PG 8
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 674OD
UT WOS:000283755700030
PM 20472418
ER
PT J
AU Lai, YC
Kao, CM
Surampalli, RY
Lin, CE
Wu, CY
AF Lai, Y. C.
Kao, C. M.
Surampalli, R. Y.
Lin, C. E.
Wu, C. Y.
TI Developing Nonpoint-Source Suspended Solids Control Strategies Using
Multimedia Watershed Management Modeling
SO WATER ENVIRONMENT RESEARCH
LA English
DT Article
DE best management practice; nonpoint-source pollution; suspended solids;
watershed management
ID QUALITY; CATCHMENT; RIVER; EXAMPLE; TAIWAN; CHINA; ROADS; LAKES; RISK
AB Kaoping River Basin is the largest and most intensively used river basin in Taiwan. In this study, 14 types of land-use patterns in the basin are classified with the aid of the Erdas Imagine process (Erdas, Inc., Atlanta, Georgia) and ArcView geographic information system (GIS) (ESRI, Redlands, California). Results from GIS identification and field verification indicate that orchard gardens, rice paddies, and sugarcane fields dominate the farmland areas in the basin. Investigation results indicate that nonpoint-source (NPS) pollution has significant contributions to the suspended solids load to the Kaoping River during the wet season. The average suspended solids concentrations increased from below 64 mg/L in dry seasons to more than 1700 mg/L in wet seasons. The Integrated Watershed Management Model (Systech Engineering, Inc., San Ramon, California) was applied to simulate the water quality and evaluate the NPS suspended solids load to the river. Modeling results show that forestation and land-use management are feasible best management practices for NPS suspended solids reduction. Water Environ. Res., 82, 2205 (2010).
C1 [Lai, Y. C.; Kao, C. M.; Lin, C. E.; Wu, C. Y.] Natl Sun Yat Sen Univ, Inst Environm Engn, Kaohsiung 80424, Taiwan.
[Surampalli, R. Y.] US EPA, Kansas City, KS USA.
RP Lai, YC (reprint author), Natl Sun Yat Sen Univ, Inst Environm Engn, 70 Lienhai Rd, Kaohsiung 80424, Taiwan.
EM jkao@mail.nsysu.edu.tw
FU Taiwan National Science Council; Taiwan Environmental Protection
Administration (Taipei, Taiwan)
FX This study was funded by Taiwan National Science Council and Taiwan
Environmental Protection Administration (Taipei, Taiwan). Additional
thanks to C.Y. Lin of the National Taipei Technology University
(Taiwan), C.Y. Chen of the Tung-Nan Institute of Technology (Taipei,
Taiwan), and C.L. Chen of Mega Tech. (Los Angeles, California), for
their assistance throughout this project. The views or opinions
expressed in this article are those of the writers and should not be
construed as opinions of the U.S. Environmental Protection Agency
(Washington, D.C.).
NR 52
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U1 1
U2 11
PU WATER ENVIRONMENT FEDERATION
PI ALEXANDRIA
PA 601 WYTHE ST, ALEXANDRIA, VA 22314-1994 USA
SN 1061-4303
J9 WATER ENVIRON RES
JI Water Environ. Res.
PD NOV
PY 2010
VL 82
IS 11
BP 2205
EP 2218
DI 10.2175/106143010X12681059116455
PG 14
WC Engineering, Environmental; Environmental Sciences; Limnology; Water
Resources
SC Engineering; Environmental Sciences & Ecology; Marine & Freshwater
Biology; Water Resources
GA 665OP
UT WOS:000283045600001
PM 21141382
ER
PT J
AU Wade, TJ
Sams, E
Brenner, KP
Haugland, R
Chern, E
Beach, M
Wymer, L
Rankin, CC
Love, D
Li, QL
Noble, R
Dufour, AP
AF Wade, Timothy J.
Sams, Elizabeth
Brenner, Kristen P.
Haugland, Richard
Chern, Eunice
Beach, Michael
Wymer, Larry
Rankin, Clifford C.
Love, David
Li, Quanlin
Noble, Rachel
Dufour, Alfred P.
TI Rapidly measured indicators of recreational water quality and
swimming-associated illness at marine beaches: a prospective cohort
study
SO ENVIRONMENTAL HEALTH
LA English
DT Article
ID REAL-TIME PCR; GASTROINTESTINAL ILLNESS; FECAL CONTAMINATION; DIARRHEAL
ILLNESS; BACTERIA; GASTROENTERITIS; CALIFORNIA; FOODNET; CULTURE; BURDEN
AB Introduction: In the United States and elsewhere, recreational water quality is monitored for fecal indicator bacteria to help prevent swimming-associated illnesses. Standard methods to measure these bacteria take at least 24 hours to obtain results. Molecular approaches such as quantitative polymerase chain reaction (qPCR) can estimate these bacteria faster, in under 3 hours. Previously, we demonstrated that measurements of the fecal indicator bacteria Enterococcus using qPCR were associated with gastrointestinal (GI) illness among swimmers at freshwater beaches. In this paper, we report on results from three marine beach sites.
Methods: We interviewed beach-goers and collected water samples at marine beaches affected by treated sewage discharges in Mississippi in 2005, and Rhode Island and Alabama in 2007. Ten to twelve days later, we obtained information about gastrointestinal, respiratory, eye, ear and skin symptoms by telephone. We tested water samples for fecal indicator organisms using qPCR and other methods.
Results: We enrolled 6,350 beach-goers. The occurrence of GI illness among swimmers was associated with a log(10)-increase in exposure to qPCR-determined estimates of fecal indicator organisms in the genus Enterococcus (AOR = 2.6, 95% CI 1.3-5.1) and order Bacteroidales (AOR = 1.9, 95% CI 1.3-2.9). Estimates of organisms related to Clostridium perfringens and a subgroup of organisms in the genus Bacteroides were also determined by qPCR in 2007, as was F+ coliphage, but relationships between these indicators and illness were not statistically significant.
Conclusions: This study provides the first evidence of a relationship between gastrointestinal illness and estimates of fecal indicator organisms determined by qPCR at marine beaches.
C1 [Wade, Timothy J.; Sams, Elizabeth; Li, Quanlin] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Brenner, Kristen P.; Haugland, Richard; Chern, Eunice; Wymer, Larry; Rankin, Clifford C.; Dufour, Alfred P.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
[Beach, Michael] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Atlanta, GA USA.
[Love, David] Johns Hopkins Univ, Baltimore, MD USA.
[Noble, Rachel] Univ N Carolina, Chapel Hill, NC USA.
RP Wade, TJ (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
EM wade.tim@epa.gov
RI Guan, Xiaokang/A-6675-2012; Li, Quanlin/H-2358-2015
OI Li, Quanlin/0000-0002-3876-0617
NR 51
TC 71
Z9 72
U1 3
U2 38
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1476-069X
J9 ENVIRON HEALTH-GLOB
JI Environ. Health
PD OCT 31
PY 2010
VL 9
AR 66
DI 10.1186/1476-069X-9-66
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA 684KY
UT WOS:000284550000001
PM 21040526
ER
PT J
AU Zhang, Y
Liu, P
Liu, XH
Jacobson, MZ
McMurry, PH
Yu, FQ
Yu, SC
Schere, KL
AF Zhang, Yang
Liu, Ping
Liu, Xiao-Huan
Jacobson, Mark Z.
McMurry, Peter H.
Yu, Fangqun
Yu, Shaocai
Schere, Kenneth L.
TI A comparative study of nucleation parameterizations: 2.
Three-dimensional model application and evaluation
SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES
LA English
DT Article
ID ACID-WATER NUCLEATION; ATMOSPHERIC PARTICLES; SIZE DISTRIBUTIONS;
SULFURIC-ACID; AEROSOL DYNAMICS; NUMBER CONCENTRATIONS; BOUNDARY-LAYER;
UNITED-STATES; ORGANIC-ACIDS; GLOBAL CCN
AB Following the examination and evaluation of 12 nucleation parameterizations presented in part 1, 11 of them representing binary, ternary, kinetic, and cluster-activated nucleation theories are evaluated in the U.S. Environmental Protection Agency Community Multiscale Air Quality (CMAQ) modeling system version 4.4. The 12-28 June 1999 Southern Oxidants Study episode is selected as a testbed to evaluate simulated particulate matter (PM) number and size predictions of CMAQ with different nucleation parameterizations. The evaluation shows that simulated domain-wide maximum PM2.5 number concentrations with different nucleation parameterizations can vary by 3 orders of magnitude. All parameterizations overpredict (by a factor of 1.4 to 1.7) the total number concentrations of accumulation-mode PM and significantly underpredict (by factors of 1.3 to 65.7) those of Aitken-mode PM, resulting in a net underprediction (by factors of 1.3 to 13.7) of the total number concentrations of PM2.5 under a polluted urban environment at a downtown station in Atlanta. The predicted number concentrations for Aitken-mode PM at this site can vary by up to 3 orders of magnitude, and those for accumulation-mode PM can vary by up to a factor of 3.2, with the best predictions by the power law of Sihto et al. (2006) (NMB of -31.7%) and the worst predictions by the ternary nucleation parameterization of Merikanto et al. (2007) (NMB of -93.1%). The ternary nucleation parameterization of Napari et al. (2002) gives relatively good agreement with observations but for a wrong reason. The power law of Kuang et al. (2008) and the binary nucleation parameterization of Harrington and Kreidenweis (1998) give better agreement than the remaining parameterizations. All the parameterizations fail to reproduce the observed temporal variations of PM number, volume, and surface area concentrations. The significant variation in the performance of these parameterizations is caused by their different theoretical bases, formulations, and dependence on temperature, relative humidity, and the ambient levels of H2SO4 and NH3. The controlling processes are different for PM number, mass, and surface areas. At urban/rural locations, some PM processes (e. g., homogeneous nucleation) and/or vertical transport may dominate the production of PM2.5 number, and emissions, or PM processes, or vertical transport or their combinations may dominate the production of PM2.5 mass and surface area. Dry deposition or some PM processes such as coagulation may dominate PM2.5 number loss, and horizontal and vertical transport, and cloud processes (e. g., cloud scavenging and wet deposition) may dominate the loss of PM2.5 mass and surface area concentrations. Sensitivity simulations show that the PM number and size distribution predictions are most sensitive to prescribed emission fractions of Aitken and accumulation-mode PM and the assumed initial PM size distribution, in addition to different nucleation parameterizations.
C1 [Zhang, Yang; Liu, Ping; Liu, Xiao-Huan] N Carolina State Univ, Dept Marine Earth & Atmospher Sci, Raleigh, NC 27695 USA.
[Liu, Ping] Shanghai Jiao Tong Univ, Sch Environm Sci & Engn, Shanghai 200030, Peoples R China.
[Liu, Xiao-Huan] Shandong Univ, Environm Res Inst, Jinan 250100, Peoples R China.
[Jacobson, Mark Z.] Stanford Univ, Dept Civil & Environm Engn, Stanford, CA 94305 USA.
[McMurry, Peter H.] Univ Minnesota Twin Cities, Dept Mech Engn, Minneapolis, MN 55455 USA.
[Yu, Fangqun] SUNY Albany, Atmospher Sci Res Ctr, Albany, NY 12222 USA.
[Yu, Shaocai; Schere, Kenneth L.] US EPA, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA.
RP Zhang, Y (reprint author), N Carolina State Univ, Dept Marine Earth & Atmospher Sci, Campus Box 8208, Raleigh, NC 27695 USA.
EM yang_zhang@ncsu.edu
RI yu, shaocai/G-7806-2011; Yu, Fangqun/F-3708-2011; McMurry,
Peter/A-8245-2008; sdu, eri/O-2991-2015; SDU, Environ Res/P-4462-2015;
yu, shaocai/F-1394-2014
OI Yu, Fangqun/0000-0003-0874-4883; McMurry, Peter/0000-0003-1609-5131;
FU NSF [Atm-0348819, ATM-0506674, AGS-0942106]; NOAA [NA03NES4400015]; U.S.
Environmental Protection Agency (EPA); U.S. Department of Commerce's
National Oceanic and Atmospheric Administration (NOAA) [DW13921548];
USDA at North Carolina State University [2008-35112-18758]
FX This work was supported by the NSF award Atm-0348819, the NOAA award
NA03NES4400015 and the Memorandum of Understanding between the U.S.
Environmental Protection Agency (EPA) and the U.S. Department of
Commerce's National Oceanic and Atmospheric Administration (NOAA) and
under agreement DW13921548, and the National Research Initiative
Competitive Grant 2008-35112-18758 from the USDA Cooperative State
Research, Education, and Extension Service Air Quality Program at North
Carolina State University. P. H. M. was supported by NSF award
ATM-0506674. F.Y. acknowledges support from NSF award AGS-0942106.
Thanks are owed to Hanna Vehkamaki, University of Helsinki, Finland, for
providing a corrected version of code for Merikanto et al.'s [2007]
parameterization, Alan Hansen, EPRI, for permitting the use of the ARIES
PM number and size distribution data for model evaluation, Prakash V.
Bhave, U.S. EPA, for helpful discussions during an early stage of this
work, and Kai Wang, NCSU, for help in postprocessing process analysis
results. Although this work was reviewed by EPA and approved for
publication, it does not necessarily reflect their policies or views.
NR 80
TC 16
Z9 16
U1 2
U2 27
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-897X
J9 J GEOPHYS RES-ATMOS
JI J. Geophys. Res.-Atmos.
PD OCT 29
PY 2010
VL 115
AR D20213
DI 10.1029/2010JD014151
PG 26
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 674MP
UT WOS:000283750600007
ER
PT J
AU Herr, DW
Mwanza, JC
Lyke, DF
Graff, JE
Moser, VC
Padilla, S
AF Herr, David W.
Mwanza, Jean-Claude
Lyke, Danielle F.
Graff, Jaimie E.
Moser, Virginia C.
Padilla, Stephanie
TI Relationship between brain and plasma carbaryl levels and cholinesterase
inhibition
SO TOXICOLOGY
LA English
DT Article
DE Carbaryl; Cholinesterase; Tissue levels; Brain; Plasma
ID IN-VITRO METABOLISM; TIME-COURSE; RATS; ACETYLCHOLINESTERASE;
SENSITIVITY; CARBAMATE; TISSUES; FETAL; TOXICOKINETICS; CHLORPYRIFOS
AB Carbaryl is a N-methylcarbamate pesticide and, like others in this class, is a reversible inhibitor of cholinesterase (ChE) enzymes. Although studied for many years, there is a surprising lack of information relating tissue levels of carbaryl with ChE activity in the same animals. The present studies were undertaken to describe the dose-response relationship about 40 min (approximate time of maximal ChE inhibition) after oral treatment in adult, post-natal day (PND) 17, and PND11 rats. Additionally, the time-course of plasma ChE activity and carbaryl levels in adult rats was determined after a 30 mg/kg dosage of carbaryl. The time-course study found that carbaryl levels could be detected in plasma 1 h after dosing, but rapidly decreased below the level of quantitation by the 2 h time point. In the dose-response studies, treatment-related increases in plasma and brain carbaryl levels were observed 40 min after dosing. Plasma levels of carbaryl increased linearly, while brain levels appeared to asymptote after 75 mg/kg carbaryl. Plasma and brain levels of carbaryl appeared to be linearly related with a slope close to 1 after various dosages (range: 1-75 mg/kg) of carbaryl at the 40 min time point. Finally, the dose-related relationship between tissue levels of carbaryl and ChE activity was described using a first order exponential decay function with an asymptote. The parameters of this function did not appear to differ between adult, PND17, or PND11 rats. This indicates that age-related differences in brain ChE inhibition by carbaryl are unlikely to be the result of greater tissue levels of the pesticide in PND11 animals. These are the first studies to report the relationship between brain and plasma tissue levels of carbaryl and ChE activity on an individual animal basis. The results of these experiments will be useful to extend physiologically-based pharmacokinetic models for carbaryl and their application in risk assessment. Published by Elsevier Ireland Ltd.
C1 [Herr, David W.; Lyke, Danielle F.; Moser, Virginia C.] US EPA, Neurotoxicol Branch, Toxic Assessment Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Res Triangle Pk, NC 27711 USA.
[Mwanza, Jean-Claude] CNR, Washington, DC 20001 USA.
[Padilla, Stephanie] US EPA, Genet & Cellular Toxicol Branch, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Res Triangle Pk, NC 27711 USA.
[Graff, Jaimie E.] US EPA, Immediate Off, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Herr, DW (reprint author), US EPA, Neurotoxicol Branch, Toxic Assessment Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, 109 TW Alexander Dr,MD B105-05, Res Triangle Pk, NC 27711 USA.
EM Herr.david@epa.gov; jcmwanza@med.miami.edu; Like.danielle@epa.gov;
Graff.jaimie@epa.gov; Moser.ginger@epa.gov; Padilla.stephanie@epa.gov
FU U.S. Environmental Protection Agency
FX The information in this document has been funded wholly (or in part) by
the U.S. Environmental Protection Agency. It has been subjected to
review by the National Health and Environmental Effects Research
Laboratory and approved for publication. Approval does not signify that
the contents reflect the views of the Agency, nor does mention of trade
names or commercial products constitute endorsement or recommendation
for use.
NR 40
TC 6
Z9 9
U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0300-483X
J9 TOXICOLOGY
JI Toxicology
PD OCT 29
PY 2010
VL 276
IS 3
BP 172
EP 183
DI 10.1016/j.tox.2010.08.001
PG 12
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 674QC
UT WOS:000283761300004
PM 20708061
ER
PT J
AU Altshuler, D
Durbin, RM
Abecasis, GR
Bentley, DR
Chakravarti, A
Clark, AG
Collins, FS
De la Vega, FM
Donnelly, P
Egholm, M
Flicek, P
Gabriel, SB
Gibbs, RA
Knoppers, BM
Lander, ES
Lehrach, H
Mardis, ER
McVean, GA
Nickerson, D
Peltonen, L
Schafer, AJ
Sherry, ST
Wang, J
Wilson, RK
Gibbs, RA
Deiros, D
Metzker, M
Muzny, D
Reid, J
Wheeler, D
Wang, J
Li, JX
Jian, M
Li, G
Li, RQ
Liang, HQ
Tian, G
Wang, B
Wang, J
Wang, W
Yang, HM
Zhang, XQ
Zheng, HS
Lander, ES
Altshuler, DL
Ambrogio, L
Bloom, T
Cibulskis, K
Fennell, TJ
Gabriel, SB
Jaffe, DB
Shefler, E
Sougnez, CL
Bentley, DR
Gormley, N
Humphray, S
Kingsbury, Z
Koko-Gonzales, P
Stone, J
McKernan, KJ
Costa, GL
Ichikawa, JK
Lee, CC
Sudbrak, R
Lehrach, H
Borodina, TA
Dahl, A
Davydov, AN
Marquardt, P
Mertes, F
Nietfeld, W
Rosenstiel, P
Schreiber, S
Soldatov, AV
Timmermann, B
Tolzmann, M
Egholm, M
Affourtit, J
Ashworth, D
Attiya, S
Bachorski, M
Buglione, E
Burke, A
Caprio, A
Celone, C
Clark, S
Conners, D
Desany, B
Gu, L
Guccione, L
Kao, K
Kebbel, A
Knowlton, J
Labrecque, M
McDade, L
Mealmaker, C
Minderman, M
Nawrocki, A
Niazi, F
Pareja, K
Ramenani, R
Riches, D
Song, W
Turcotte, C
Wang, S
Mardis, ER
Dooling, D
Fulton, L
Fulton, R
Weinstock, G
Durbin, RM
Burton, J
Carter, DM
Churcher, C
Coffey, A
Cox, A
Palotie, A
Quail, M
Skelly, T
Stalker, J
Swerdlow, HP
Turner, D
De Witte, A
Giles, S
Gibbs, RA
Wheeler, D
Bainbridge, M
Challis, D
Sabo, A
Yu, F
Yu, J
Wang, J
Fang, XD
Guo, XS
Li, RQ
Li, YR
Luo, RB
Tai, S
Wu, HL
Zheng, HC
Zheng, XL
Zhou, Y
Yang, HM
Marth, GT
Garrison, EP
Huang, W
Indap, A
Kural, D
Lee, WP
Leong, WF
Huang, WC
Indap, A
Kural, D
Lee, WP
Leong, WF
Quinlan, AR
Stewart, C
Stromberg, MP
Ward, AN
Wu, JT
Lee, C
Mills, RE
Shi, XH
Daly, MJ
DePristo, MA
Altshuler, DL
Ball, AD
Banks, E
Bloom, T
Browning, BL
Cibulskis, K
Fennell, TJ
Garimella, KV
Grossman, SR
Handsaker, RE
Hanna, M
Hartl, C
Jaffe, DB
Kernytsky, AM
Korn, JM
Li, H
Maguire, JR
McCarroll, SA
McKenna, A
Nemesh, JC
Philippakis, AA
Poplin, RE
Price, A
Rivas, MA
Sabeti, PC
Schaffner, SF
Shefler, E
Shlyakhter, IA
Cooper, DN
Ball, EV
Mort, M
Phillips, AD
Stenson, PD
Sebat, J
Makarov, V
Ye, K
Yoon, SC
Bustamante, CD
Clark, AG
Boyko, A
Degenhardt, J
Gravel, S
Gutenkunst, RN
Kaganovich, M
Keinan, A
Lacroute, P
Ma, X
Reynolds, A
Clarke, L
Flicek, P
Cunningham, F
Herrero, J
Keenen, S
Kulesha, E
Leinonen, R
McLaren, W
Radhakrishnan, R
Smith, RE
Zalunin, V
Zheng-Bradley, XQ
Korbel, JO
Stutz, AM
Humphray, S
Bauer, M
Cheetham, RK
Cox, T
Eberle, M
James, T
Kahn, S
Murray, L
Ye, K
De La Vega, FM
Fu, YT
Hyland, FCL
Manning, JM
McLaughlin, SF
Peckham, HE
Sakarya, O
Sun, YA
Tsung, EF
Batzer, MA
Konkel, MK
Walker, JA
Sudbrak, R
Albrecht, MW
Amstislavskiy, VS
Herwig, R
Parkhomchuk, DV
Sherry, ST
Agarwala, R
Khouri, H
Morgulis, AO
Paschall, JE
Phan, LD
Rotmistrovsky, KE
Sanders, RD
Shumway, MF
Xiao, CL
McVean, GA
Auton, A
Iqbal, Z
Lunter, G
Marchini, JL
Moutsianas, L
Myers, S
Tumian, A
Desany, B
Knight, J
Winer, R
Craig, DW
Beckstrom-Sternberg, SM
Christoforides, A
Kurdoglu, AA
Pearson, J
Sinari, SA
Tembe, WD
Haussler, D
Hinrichs, AS
Katzman, SJ
Kern, A
Kuhn, RM
Przeworski, M
Hernandez, RD
Howie, B
Kelley, JL
Melton, SC
Abecasis, GR
Li, Y
Anderson, P
Blackwell, T
Chen, W
Cookson, WO
Ding, J
Kang, HM
Lathrop, M
Liang, LM
Moffatt, MF
Scheet, P
Sidore, C
Snyder, M
Zhan, XW
Zollner, S
Awadalla, P
Casals, F
Idaghdour, Y
Keebler, J
Stone, EA
Zilversmit, M
Jorde, L
Xing, JC
Eichler, EE
Aksay, G
Alkan, C
Hajirasouliha, I
Hormozdiari, F
Kidd, JM
Sahinalp, SC
Sudmant, PH
Mardis, ER
Chen, K
Chinwalla, A
Ding, L
Koboldt, DC
McLellan, MD
Dooling, D
Weinstock, G
Wallis, JW
Wendl, MC
Zhang, QY
Durbin, RM
Albers, CA
Ayub, Q
Balasubramaniam, S
Barrett, JC
Carter, DM
Chen, YA
Conrad, DF
Danecek, P
Dermitzakis, ET
Hu, M
Huang, N
Hurles, ME
Jin, HJ
Jostins, L
Keane, TM
Keane, TM
Le, SQ
Lindsay, S
Long, QA
MacArthur, DG
Montgomery, SB
Parts, L
Stalker, J
Tyler-Smith, C
Walter, K
Zhang, YJ
Gerstein, MB
Snyder, M
Abyzov, A
Abyzov, A
Balasubramanian, S
Bjornson, R
Du, JA
Grubert, F
Habegger, L
Haraksingh, R
Jee, J
Khurana, E
Lam, HYK
Leng, J
Mu, XJ
Urban, AE
Zhang, ZD
Li, YR
Luo, RB
Marth, GT
Garrison, EP
Kural, D
Quinlan, AR
Stewart, C
Stromberg, MP
Ward, AN
Wu, JT
Lee, C
Mills, RE
Shi, XH
McCarroll, SA
Banks, E
DePristo, MA
Handsaker, RE
Hartl, C
Korn, JM
Li, H
Nemesh, JC
Sebat, J
Makarov, V
Ye, K
Yoon, SC
Degenhardt, J
Kaganovich, M
Clarke, L
Smith, RE
Zheng-Bradley, XQ
Korbel, JO
Humphray, S
Cheetham, RK
Eberle, M
Kahn, S
Murray, L
Ye, K
De la Vega, FM
Fu, YT
Peckham, HE
Sun, YA
Batzer, MA
Konkel, MK
Xiao, CL
Iqbal, Z
Desany, B
Blackwell, T
Snyder, M
Xing, JC
Eichler, EE
Aksay, G
Alkan, C
Hajirasouliha, I
Hormozdiari, F
Kidd, JM
Chen, K
Chinwalla, A
Ding, L
McLellan, MD
Wallis, JW
Hurles, ME
Conrad, DF
Walter, K
Zhang, YJ
Gerstein, MB
Snyder, M
Abyzov, A
Du, JA
Grubert, F
Haraksingh, R
Jee, J
Khurana, E
Lam, HYK
Leng, J
Mu, XJ
Urban, AE
Zhang, ZD
Gibbs, RA
Bainbridge, M
Challis, D
Coafra, C
Dinh, H
Kovar, C
Lee, S
Muzny, D
Nazareth, L
Reid, J
Sabo, A
Yu, FL
Yu, J
Marth, GT
Garrison, EP
Indap, A
Leong, WF
Quinlan, AR
Stewart, C
Ward, AN
Wu, JT
Cibulskis, K
Fennell, TJ
Gabriel, SB
Garimella, KV
Hartl, C
Shefler, E
Sougnez, CL
Wilkinson, J
Clark, AG
Gravel, S
Grubert, F
Clarke, L
Flicek, P
Smith, RE
Zheng-Bradley, XQ
Sherry, ST
Khouri, HM
Paschall, JE
Shumway, MF
Xiao, CL
McVean, GA
Katzman, SJ
Abecasis, GR
Blackwell, T
Mardis, ER
Dooling, D
Fulton, L
Fulton, R
Koboldt, DC
Durbin, RM
Balasubramaniam, S
Coffey, A
Keane, TM
MacArthur, DG
Palotie, A
Scott, C
Stalker, J
Tyler-Smith, C
Gerstein, MB
Balasubramanian, S
Chakravarti, A
Knoppers, BM
Peltonen, L
Abecasis, GR
Bustamante, CD
Gharani, N
Gibbs, RA
Jorde, L
Kaye, JS
Kent, A
Li, T
McGuire, AL
McVean, GA
Ossorio, PN
Rotimi, CN
Su, YY
Toji, LH
Tyler-Smith, C
Brooks, LD
Felsenfeld, AL
McEwen, JE
Abdallah, A
Christopher, R
Clemm, NC
Collins, FS
Duncanson, A
Green, ED
Guyer, MS
Peterson, JL
Schafer, AJ
Abecasis, GR
Altshuler, DL
Auton, A
Brooks, LD
Durbin, RM
Gibbs, RA
Hurles, ME
McVean, GA
AF Altshuler, David
Durbin, Richard M.
Abecasis, Goncalo R.
Bentley, David R.
Chakravarti, Aravinda
Clark, Andrew G.
Collins, Francis S.
De la Vega, Francisco M.
Donnelly, Peter
Egholm, Michael
Flicek, Paul
Gabriel, Stacey B.
Gibbs, Richard A.
Knoppers, Bartha M.
Lander, Eric S.
Lehrach, Hans
Mardis, Elaine R.
McVean, Gil A.
Nickerson, DebbieA.
Peltonen, Leena
Schafer, Alan J.
Sherry, Stephen T.
Wang, Jun
Wilson, Richard K.
Gibbs, Richard A.
Deiros, David
Metzker, Mike
Muzny, Donna
Reid, Jeff
Wheeler, David
Wang, Jun
Li, Jingxiang
Jian, Min
Li, Guoqing
Li, Ruiqiang
Liang, Huiqing
Tian, Geng
Wang, Bo
Wang, Jian
Wang, Wei
Yang, Huanming
Zhang, Xiuqing
Zheng, Huisong
Lander, Eric S.
Altshuler, David L.
Ambrogio, Lauren
Bloom, Toby
Cibulskis, Kristian
Fennell, Tim J.
Gabriel, Stacey B.
Jaffe, David B.
Shefler, Erica
Sougnez, Carrie L.
Bentley, David R.
Gormley, Niall
Humphray, Sean
Kingsbury, Zoya
Koko-Gonzales, Paula
Stone, Jennifer
McKernan, Kevin J.
Costa, Gina L.
Ichikawa, Jeffry K.
Lee, Clarence C.
Sudbrak, Ralf
Lehrach, Hans
Borodina, Tatiana A.
Dahl, Andreas
Davydov, Alexey N.
Marquardt, Peter
Mertes, Florian
Nietfeld, Wilfiried
Rosenstiel, Philip
Schreiber, Stefan
Soldatov, Aleksey V.
Timmermann, Bernd
Tolzmann, Marius
Egholm, Michael
Affourtit, Jason
Ashworth, Dana
Attiya, Said
Bachorski, Melissa
Buglione, Eli
Burke, Adam
Caprio, Amanda
Celone, Christopher
Clark, Shauna
Conners, David
Desany, Brian
Gu, Lisa
Guccione, Lorri
Kao, Kalvin
Kebbel, Andrew
Knowlton, Jennifer
Labrecque, Matthew
McDade, Louise
Mealmaker, Craig
Minderman, Melissa
Nawrocki, Anne
Niazi, Faheem
Pareja, Kristen
Ramenani, Ravi
Riches, David
Song, Wanmin
Turcotte, Cynthia
Wang, Shally
Mardis, Elaine R.
Dooling, David
Fulton, Lucinda
Fulton, Robert
Weinstock, George
Durbin, Richard M.
Burton, John
Carter, David M.
Churcher, Carol
Coffey, Alison
Cox, Anthony
Palotie, Aarno
Quail, Michael
Skelly, Tom
Stalker, James
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McVean, Gil A.
Katzman, Sol J.
Abecasis, Goncalo R.
Blackwell, Tom
Mardis, Elaine R.
Dooling, David
Fulton, Lucinda
Fulton, Robert
Koboldt, Daniel C.
Durbin, Richard M.
Balasubramaniam, Senduran
Coffey, Allison
Keane, Thomas M.
MacArthur, Daniel G.
Palotie, Aarno
Scott, Carol
Stalker, James
Tyler-Smith, Chris
Gerstein, Mark B.
Balasubramanian, Suganthi
Chakravarti, Aravinda
Knoppers, Bartha M.
Peltonen, Leena
Abecasis, Goncalo R.
Bustamante, Carlos D.
Gharani, Neda
Gibbs, Richard A.
Jorde, Lynn
Kaye, Jane S.
Kent, Alastair
Li, Taosha
McGuire, Amy L.
McVean, Gil A.
Ossorio, Pilar N.
Rotimi, Charles N.
Su, Yeyang
Toji, Lorraine H.
Tyler-Smith, Chris
Brooks, Lisa D.
Felsenfeld, Adam L.
McEwen, Jean E.
Abdallah, Assya
Juenger, Christopher R.
Clemm, Nicholas C.
Collins, Francis S.
Duncanson, Audrey
Green, Eric D.
Guyer, Mark S.
Peterson, Jane L.
Schafer, Alan J.
Abecasis, Goncalo R.
Altshuler, David L.
Auton, Adam
Brooks, Lisa D.
Durbin, Richard M.
Gibbs, Richard A.
Hurles, Matt E.
McVean, Gil A.
CA 1000 Genomes Project Consortium
TI A map of human genome variation from population-scale sequencing
SO NATURE
LA English
DT Article
ID WIDE ASSOCIATION; GENE-EXPRESSION; RECOMBINATION HOTSPOTS; MEIOTIC
RECOMBINATION; GENOTYPE IMPUTATION; RARE VARIANTS; HAPLOTYPE MAP;
NUCLEOTIDE; DISEASES; COMMON
AB The 1000 Genomes Project aims to provide a deep characterization of human genome sequence variation as a foundation for investigating the relationship between genotype and phenotype. Here we present results of the pilot phase of the project, designed to develop and compare different strategies for genome-wide sequencing with high-throughput platforms. We undertook three projects: low-coverage whole-genome sequencing of 179 individuals from four populations; high-coverage sequencing of two mother-father-child trios; and exon-targeted sequencing of 697 individuals from seven populations. We describe the location, allele frequency and local haplotype structure of approximately 15 million single nucleotide polymorphisms, 1 million short insertions and deletions, and 20,000 structural variants, most of which were previously undescribed. We show that, because we have catalogued the vast majority of common variation, over 95% of the currently accessible variants found in any individual are present in this data set. On average, each person is found to carry approximately 250 to 300 loss-of-function variants in annotated genes and 50 to 100 variants previously implicated in inherited disorders. We demonstrate how these results can be used to inform association and functional studies. From the two trios, we directly estimate the rate of de novo germline base substitution mutations to be approximately 10(-8) per base pair per generation. We explore the data with regard to signatures of natural selection, and identify a marked reduction of genetic variation in the neighbourhood of genes, due to selection at linked sites. These methods and public data will support the next phase of human genetic research.
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[Ossorio, Pilar N.] Univ Wisconsin Madison, Dept Med Hist & Bioeth, Madison, WI 53706 USA.
[Rotimi, Charles N.] US Natl Inst Hlth, Ctr Res Genom & Global Hlth, Bethesda, MD 20892 USA.
[Brooks, Lisa D.; Felsenfeld, Adam L.; McEwen, Jean E.; Clemm, Nicholas C.; Green, Eric D.; Guyer, Mark S.; Peterson, Jane L.; Brooks, Lisa D.] US Natl Inst Hlth, NHGRI, Bethesda, MD 20892 USA.
[Abdallah, Assya] George Washington Univ, Sch Med & Hlth Sci, Washington, DC 20037 USA.
[Juenger, Christopher R.] US FDA, Rockville, MD 20857 USA.
RP Durbin, RM (reprint author), Wellcome Trust Sanger Inst, Wellcome Trust Genome Campus, Cambridge CB10 1SA, England.
RI Wang, Jun/B-9503-2016; Casals, Ferran/H-4347-2015; Wang,
Jun/C-8434-2016; Lunter, Gerton/H-4939-2016; Pearson, John/F-2249-2011;
Mu, Xinmeng/P-2562-2016; Stone, Eric/Q-7840-2016; Mills,
Ryan/A-1979-2011; Dahl, Andreas/E-3783-2017; Ye, Kai/B-3640-2012;
Cartwright, Reed/A-9707-2009; Wendl, Michael/A-2741-2008; Rosenstiel,
Philip/A-5137-2009; Korbel, Jan/G-6470-2012; Kelley, Joanna/H-1693-2012;
Dermitzakis, Emmanouil/B-7687-2013; Khurana, Ekta/C-4933-2013; Abyzov,
Alexej/M-4284-2013; Le, Quang/A-4861-2012; Myers, Simon/A-6792-2015;
Tumian, Afidalina/J-4404-2014; Li, Yingrui/K-1064-2015; Albers,
Kees/A-4170-2015; Li, Heng/D-9344-2011; De La Vega,
Francisco/H-3832-2011; Cooper, David/H-4384-2011; Xing,
Jinchuan/A-2489-2012; Sincan, Murat /A-3794-2010; Alkan,
Can/D-2982-2009; Abecasis, Goncalo/B-7840-2010; Chen, Ken/A-1074-2009;
Altshuler, David/A-4476-2009; MacArthur, Daniel/E-3275-2010; Browning,
Brian/A-1178-2010; Schreiber, Stefan/B-6748-2008; Schaffner,
Stephen/D-1189-2011; Ding, Jun/G-3918-2011
OI Hinrichs, Angie/0000-0002-1697-1130; Lunter, Gerton/0000-0002-3798-2058;
Iqbal, Zamin/0000-0001-8466-7547; Keane, Thomas/0000-0001-7532-6898;
Abecasis, Goncalo/0000-0003-1509-1825; Ayub, Qasim/0000-0003-3291-0917;
Herrero, Javier/0000-0001-7313-717X; Clarke, Laura/0000-0002-5989-6898;
Yu, Jin/0000-0002-2990-6602; Flicek, Paul/0000-0002-3897-7955; McLaren,
William/0000-0001-6218-1116; Walter, Klaudia/0000-0003-4448-0301; Wang,
Jun/0000-0002-2113-5874; Leinonen, Rasko/0000-0002-2639-7187; Kulesha,
Eugene/0000-0002-4285-6232; Haraksingh, Rajini/0000-0002-6644-8874;
Zalunin, Vadim/0000-0002-7722-1958; Kelley, Joanna/0000-0002-7731-605X;
Zheng Bradley, Xiangqun/0000-0002-9324-2708; Abyzov,
Alexej/0000-0001-5405-6729; Keenan, Stephen/0000-0002-9141-7690; Sebat,
Jonathan/0000-0002-9087-526X; Sudmant, Peter/0000-0002-9573-8248; Kidd,
Jeffrey/0000-0002-9631-1465; Radhakrishnan, Rajesh/0000-0001-7170-699X;
Sidore, Carlo/0000-0001-7504-7477; Lindsay, Sarah/0000-0002-0965-3070;
Casals, Ferran/0000-0002-8941-0369; Wang, Jun/0000-0002-8540-8931;
Pearson, John/0000-0003-0904-4598; Mu, Xinmeng/0000-0002-8079-0828;
Mills, Ryan/0000-0003-3425-6998; Dahl, Andreas/0000-0002-2668-8371;
Stuetz, Adrian/0000-0001-7650-3470; Cunningham,
Fiona/0000-0002-7445-2419; Quinlan, Aaron/0000-0003-1756-0859; Durbin,
Richard/0000-0002-9130-1006; Rosenstiel, Philip/0000-0002-9692-8828;
Korbel, Jan/0000-0002-2798-3794; Le, Quang/0000-0002-3715-210X; Myers,
Simon/0000-0002-2585-9626; Tumian, Afidalina/0000-0003-2763-6677;
Albers, Kees/0000-0003-4115-3727; Li, Heng/0000-0003-4874-2874; Cooper,
David/0000-0002-8943-8484; Alkan, Can/0000-0002-5443-0706; Altshuler,
David/0000-0002-7250-4107; Browning, Brian/0000-0001-6454-6633;
Schreiber, Stefan/0000-0003-2254-7771;
FU Wellcome Trust [WT089088/Z/09/Z, WT085532AIA, WT086084/Z/08/Z,
WT081407/Z/06/Z, WT075491/Z/04, WT077009]; Medical Research Council
[G0801823]; British Heart Foundation [RG/09/012/28096]; The Leverhulme
Trust; EPSRC; Louis-Jeantet Foundation; Swiss National Science
Foundation; NGI/EBI [050-72-436]; National Basic Research Program of
China (973 program) [2011CB809200]; National Natural Science Foundation
of China [30725008, 30890032, 30811130531, 30221004]; Chinese 863
program [2006AA02Z177, 2006AA02Z334, 2006AA02A302, 2009AA022707];
Shenzhen Municipal Government of China [JC200903190767A,
JC200903190772A, CXB200903110066A, ZYC200903240077A, ZYC200903240076A,
ZYC200903240080A]; Danish Natural Science Research Council; German
Research Foundation (Deutsche Forschungsgemeinschaft); BMBF [01GS08201,
PREDICT 0315428A]; BMBF NGFN PLUS; EU [242257]; Max Planck Society;
Genome Quebec; Ministry of Economic Development, Innovation and Trade
[PSR-SIIRI-195]; National Library of Medicine; National Institute of
Environmental Health Sciences; NIH [P41HG4221, U01HG5209, P41HG4222,
R01GM59290, R01GM72861, R01HG2651, R01MH84698, U01HG5214, P01HG4120,
U54HG2750, U54HG2757, U01HG5210, U01HG5208, U01HG5211, R01HG3698,
R01HG4719, RC2HG5552, R01HG3229, P50HG2357, R01HG4960, P41HG2371,
U41HG4568, R01HG4333]; BWF and Packard Foundation; Pew Charitable Trust;
NSF; [S10RR025056]
FX We thank many people who contributed to this project: K. Beal, S.
Fitzgerald, G. Cochrane, V. Silventoinen, P. Jokinen, E. Birney and J.
Ahringer for comments on the manuscript; T. Hunkapiller and Q. Doan for
their advice and coordination; N. Kalin, F. Laplace, J. Wilde, S.
Paturej, I. Kuhndahl, J. Knight, C. Kodira and M. Boehnke for valuable
discussions; Z. Cheng, S. Sajjadian and F. Hormozdiari for assistance in
managing data sets; and D. Leja for help with the figures. We thank the
Yoruba in Ibadan, Nigeria, the Han Chinese in Beijing, China, the
Japanese in Tokyo, Japan, the Utah CEPH community, the Luhya in Webuye,
Kenya, the Toscani in Italia, and the Chinese in Denver, Colorado, for
contributing samples for research. This research was supported in part
by Wellcome Trust grants WT089088/Z/09/Z to R. M. D.; WT085532AIA to P.
F.; WT086084/Z/08/Z to G. A. M.; WT081407/Z/06/Z to J. S. K.;
WT075491/Z/04 to G. L.; WT077009 to C.T.-S.; Medical Research Council
grant G0801823 to J. L. M.; British Heart Foundation grant
RG/09/012/28096 to C. A.; The Leverhulme Trust and EPSRC studentships to
L. M. and A. T.; the Louis-Jeantet Foundation and Swiss National Science
Foundation in support of E. T. D. and S. B. M.; NGI/EBI fellowship
050-72-436 to K.Y.; a National Basic Research Program of China (973
program no. 2011CB809200); the National Natural Science Foundation of
China (30725008, 30890032, 30811130531, 30221004); the Chinese 863
program (2006AA02Z177, 2006AA02Z334, 2006AA02A302, 2009AA022707); the
Shenzhen Municipal Government of China (grants JC200903190767A,
JC200903190772A, ZYC200903240076A, CXB200903110066A, ZYC200903240077A,
ZYC200903240076A and ZYC200903240080A); the Ole Romer grant from the
Danish Natural Science Research Council; an Emmy Noether Fellowship of
the German Research Foundation (Deutsche Forschungsgemeinschaft) to
J.O.K.; BMBF grant 01GS08201; BMBF grant PREDICT 0315428A to R. H.; BMBF
NGFN PLUS and EU 6th framework READNA to S. S.; EU 7th framework 242257
to A. V. S.; the Max Planck Society; a grant from Genome Quebec and the
Ministry of Economic Development, Innovation and Trade, PSR-SIIRI-195 to
P. A.; the Intramural Research Program of the NIH; the National Library
of Medicine; the National Institute of Environmental Health Sciences;
and NIH grants P41HG4221 and U01HG5209 to C. L.; P41HG4222 to J. S.;
R01GM59290 to L. B. J. and M. A. B.; R01GM72861 to M. P.; R01HG2651 and
R01MH84698 to G. R. A.; U01HG5214 to G. R. A. and A. C.; P01HG4120 to E.
E. E.; U54HG2750 to D. L. A.; U54HG2757 to A. C.; U01HG5210 to D. C.;
U01HG5208 to M. J. D.; U01HG5211 to R. A. G.; R01HG3698, R01HG4719 and
RC2HG5552 to G. T. M.; R01HG3229 to C. D. B. and A. G. C.; P50HG2357 to
M. S.; R01HG4960 to B. L. B; P41HG2371 and U41HG4568 to D. H.; R01HG4333
to A. M. L.; U54HG3273 to R. A. G.; U54HG3067 to E. S. L.; U54HG3079 to
R. K. W.; N01HG62088 to the Coriell Institute; S10RR025056 to the
Translational Genomics Research Institute; Al Williams Professorship
funds for M. B. G.; the BWF and Packard Foundation support for P. C. S.;
the Pew Charitable Trusts support for G. R. A.; and an NSF Minority
Postdoctoral Fellowship in support of R. D. H. E. E. E. is an HHMI
investigator, M. P. is an HHMI Early Career Scientist, and D. M. A. is
Distinguished Clinical Scholar of the Doris Duke Charitable Foundation.
NR 50
TC 2999
Z9 3054
U1 70
U2 580
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
EI 1476-4687
J9 NATURE
JI Nature
PD OCT 28
PY 2010
VL 467
IS 7319
BP 1061
EP 1073
DI 10.1038/nature09534
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 671XW
UT WOS:000283548600039
ER
PT J
AU Boethling, R
Davies, C
Fehrenbacher, C
Lavoie, E
Libelo, L
Sommer, E
Henry, T
Howard, P
Meylan, W
Morlacci, L
Tunkel, J
Webb, T
Mayo, K
Waugh, W
Zeeman, M
AF Boethling, Robert
Davies, Clive
Fehrenbacher, Cathy
Lavoie, Emma
Libelo, Laurence
Sommer, Elizabeth
Henry, Tala
Howard, Philip
Meylan, William
Morlacci, Laura
Tunkel, Jay
Webb, Thomas
Mayo, Kelly
Waugh, William
Zeeman, Maurice
TI Comment on "More of EPA's SPARC Online Calculator-The Need for
High-Quality Predictions of Chemical Properties"
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Letter
C1 [Boethling, Robert; Davies, Clive; Fehrenbacher, Cathy; Lavoie, Emma; Libelo, Laurence; Sommer, Elizabeth] US EPA, Econ Exposure & Technol Div, Washington, DC 20460 USA.
[Henry, Tala] US EPA, Natl Program Chem Div, Washington, DC 20460 USA.
[Howard, Philip; Meylan, William; Morlacci, Laura; Tunkel, Jay; Webb, Thomas] SRC Inc, N Syracuse, NY USA.
[Mayo, Kelly; Waugh, William; Zeeman, Maurice] US EPA, Risk Assessment Div, Washington, DC 20460 USA.
RP Boethling, R (reprint author), US EPA, Econ Exposure & Technol Div, Washington, DC 20460 USA.
EM Boethling.bob@epa.gov
NR 2
TC 2
Z9 2
U1 0
U2 8
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD OCT 15
PY 2010
VL 44
IS 20
BP 7745
EP 7745
DI 10.1021/es102727q
PG 1
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 661KP
UT WOS:000282727500001
PM 20831212
ER
PT J
AU Qu, XL
Hwang, YS
Alvarez, PJJ
Bouchard, D
Li, QL
AF Qu, Xiaolei
Hwang, Yu Sik
Alvarez, Pedro J. J.
Bouchard, Dermont
Li, Qilin
TI UV Irradiation and Humic Acid Mediate Aggregation of Aqueous Fullerene
(nC(60)) Nanoparticles
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID WALLED CARBON NANOTUBES; NATURAL ORGANIC-MATTER; C-60 NANOPARTICLES;
PHOTOCHEMICAL TRANSFORMATION; MANUFACTURED NANOMATERIALS; PHOTOCATALYTIC
OXIDATION; ANTIBACTERIAL ACTIVITY; COLLOIDAL PROPERTIES; WATER
SUSPENSIONS; CALCIUM-IONS
AB The transport and fate of engineered nanomaterials is affected by multiple environmental factors, including sunlight and natural organic matter. In this study, the initial aggregation kinetics of aqueous fullerene (nC(60)) nanoparticles before and after UVA irradiation was investigated in solutions varying in ionic strength, ionic composition, and humic acid concentration. In NaCl solutions, surface oxidation induced by UV irradiation remarkably increased nC(60) stability due to the increased negative surface charge and reduced particle hydrophobicity; although humic acid greatly enhanced the stability of pristine nC(60) via the steric hindrance effect, it had little influence on the stability of UV-irradiated nC(60) in NaCl due to reduced adsorption on oxidized nC(60) surface. In contrast, UV irradiation reduced nC(60) stability in CaCl2 due to specific interactions of Ca2+ with the negatively charged functional groups on UV-irradiated nC(60) surface and the consequent charge neutralization. By neutralizing surface charges of both UV-irradiated nC(60) and humic acid as well as forming intermolecular bridges, Ca2+ facilitated humic acid adsorption on UV-irradiated nC(60), resulting in enhanced stability in the presence of humic acid. These results demonstrate the critical role of nC(60) surface chemistry in its environmental transport and fate.
C1 [Qu, Xiaolei; Hwang, Yu Sik; Alvarez, Pedro J. J.; Li, Qilin] Rice Univ, Dept Civil & Environm Engn, Houston, TX 77005 USA.
[Bouchard, Dermont] US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA.
RP Li, QL (reprint author), Univ Seoul, Grad Sch Energy & Environm Syst Engn, Seoul 130743, South Korea.
EM hwangyusik@gmail.com; qilin.li@rice.edu
RI Qu, Xiaolei/J-1432-2012
FU NSF Center for Biological and Environmental Nanotechnology
[EEC-0647452]; USEPA [834093]
FX This work was supported by the NSF Center for Biological and
Environmental Nanotechnology (Award EEC-0647452) and the USEPA STAR
program (Grant 834093).
NR 40
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U1 6
U2 104
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD OCT 15
PY 2010
VL 44
IS 20
BP 7821
EP 7826
DI 10.1021/es101947f
PG 6
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 661KP
UT WOS:000282727500017
PM 20866048
ER
PT J
AU Betterton, EA
Lowry, J
Ingarnells, R
Venner, B
AF Betterton, Eric A.
Lowry, Joe
Ingarnells, Robin
Venner, Brad
TI Kinetics and mechanism of the reaction of sodium azide with hypochlorite
in aqueous solution
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Article
DE Azide; Hypochlorite; Chlorine azide; Air bag; Kinetics and mechanism;
Water treatment
ID NONMETAL REDOX KINETICS; ACID-ASSISTED OXIDATION; BROMINE CHLORIDE;
HYDRAZOIC ACID; HALOGEN AZIDES; AIR BAG; ION; EQUILIBRIUM; CHEMISTRY;
OZONE
AB Production of toxic sodium azide (NaN(3)) surged worldwide over the past two decades to meet the demand for automobile air bag inflator propellant. Industrial activity and the return of millions of inflators to automobile recycling facilities are leading to increasing release of NaN(3) to the environment so there is considerable interest in learning more about its environmental fate. Water soluble NaN(3) could conceivably be found in drinking water supplies so here we describe the kinetics and mechanism of the reaction of azide with hypochlorite, which is often used in water treatment plants. The reaction stoichiometry is: HOCl + 2N(3)(-) = 3N(2) + Cl(-) + OH(-), and proceeds by a key intermediate chlorine azide, ClN(3), which subsequently decomposes by reaction with a second azide molecule in the rate determining step: ClN(3) + N(3)(-) -> 3N(2) + Cl(-) (k = 0.52 +/- 0.04 M(-1) s(-1), 25 degrees C, mu = 0.1 M). We estimate that the half-life of azide would be approximate to 15 s at the point of chlorination in a water treatment plant and approximate to 24 days at some point downstream where only residual chlorine remains. Hypochlorite is not recommended for treatment of concentrated azide waste due to formation of the toxic chlorine azide intermediate under acidic conditions and the slow kinetics under basic conditions. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Betterton, Eric A.] Univ Arizona, Dept Atmospher Sci, Tucson, AZ 85724 USA.
[Lowry, Joe; Venner, Brad] US EPA, Natl Enforcement Invest Ctr, Denver Fed Ctr, Denver, CO 80225 USA.
RP Betterton, EA (reprint author), Univ Arizona, Dept Atmospher Sci, POB 210081, Tucson, AZ 85724 USA.
EM betterton@atmo.arizona.edu
NR 43
TC 8
Z9 8
U1 3
U2 29
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3894
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD OCT 15
PY 2010
VL 182
IS 1-3
BP 716
EP 722
DI 10.1016/j.jhazmat.2010.06.093
PG 7
WC Engineering, Environmental; Engineering, Civil; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 655HV
UT WOS:000282240800093
PM 20667654
ER
PT J
AU Miller, MF
Loch-Caruso, R
AF Miller, Mark F.
Loch-Caruso, Rita
TI Comparison of LPS-stimulated release of cytokines in punch versus
transwell tissue culture systems of human gestational membranes
SO REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
LA English
DT Article
ID HUMAN FETAL MEMBRANES; TUMOR-NECROSIS-FACTOR; AMNIOTIC-FLUID
INTERLEUKIN-6; EXTRA-PLACENTAL MEMBRANES; LABOR-ASSOCIATED CHANGES;
FACTOR-ALPHA RELEASE; INFLAMMATORY CYTOKINES; HUMAN-PREGNANCY; PRETERM
LABOR; IN-VITRO
AB Background: Cytokine signaling within the amnionic, chorionic and decidual extraplacental gestational membranes plays an important role in membrane rupture and the timing of birth. The predominant in vitro explant culture system for evaluating cytokine induction in human gestational membranes has been the free-floating biopsy punch culture. Punch systems have been used to investigate the impact of various toxicants, pharmaceuticals and genetic variation on expression of pro-inflammatory cytokines. More recently, a dual compartment transwell culture system has been developed that more closely mimics the intrauterine compartment. The current study compares these two systems with respect to release of pro-and antiinflammatory cytokines in response to lipopolysaccharide (LPS), a model stimulant.
Methods: Tissue samples were exposed to 100 ng/ml LPS for 12 h and cytokines were measured by ELISA. Data are expressed as increase relative to non-treated controls.
Results: Levels of interleukin-6 increased in punch culture medium samples to a significantly greater extent (34.2 fold) compared with medium from transwell cultures in the amnion (6.6 fold) or choriodecidual (7.1 fold) compartments. Interleukin-8 also showed a significantly greater induction in punch (4.8 fold) than transwell amnion (1.6 fold) or choriodecidual (1.7 fold) samples. The anti-inflammatory interleukin-10 showed a significant difference between punch (36.5 fold) and transwell amnion (15.4 fold) samples, but no difference was observed between punch and transwell choriodecidual (28.5 fold) samples. Neither interleukin-1beta nor tumor necrosis factor-alpha (TNF-alpha) showed a significant difference between the punch and transwell samples.
Conclusions: These results indicate that the pattern of LPS-stimulated cytokine release from gestational membranes in vitro depends on the culture system used, confounding comparisons of studies that use different gestational membrane culture systems to study inflammatory responses.
C1 [Miller, Mark F.; Loch-Caruso, Rita] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA.
[Miller, Mark F.] US Environm Protect Agcy HQ, Washington, DC 20460 USA.
RP Miller, MF (reprint author), Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA.
EM miller.mark@epa.gov
OI Loch-Caruso, Rita/0000-0002-5993-2799
FU National Institute of Environmental Health Sciences (NIEHS), National
Institutes of Health (NIH) [R01 ES014860, T32 ES07062]; University of
Michigan; Society of Toxicology; National Institute of Child Health and
Human Development, NIH [T32 HD007048]; University of Michigan Department
of Environmental Health Sciences
FX We thank the staff of the University of Michigan Women's Hospital Birth
Center for assisting with acquisition of human gestational tissues used
in this research, especially Dr. Mark Chames. Funding for this research
has been provided by grants to RLC from the National Institute of
Environmental Health Sciences (NIEHS), National Institutes of Health
(NIH) [R01 ES014860]; University of Michigan [Elizabeth H. Crosby
Award]; and Society of Toxicology [Colgate-Palmolive Grant for
Alternative Research]. Additional support for MFM was provided by
Institutional Training Grants from the NIEHS, NIH [T32 ES07062];
National Institute of Child Health and Human Development, NIH [T32
HD007048]; and University of Michigan Department of Environmental Health
Sciences.
NR 43
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U1 0
U2 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1477-7827
J9 REPROD BIOL ENDOCRIN
JI Reprod. Biol. Endocrinol.
PD OCT 15
PY 2010
VL 8
AR 121
DI 10.1186/1477-7827-8-121
PG 8
WC Endocrinology & Metabolism; Reproductive Biology
SC Endocrinology & Metabolism; Reproductive Biology
GA 671VV
UT WOS:000283540400001
PM 20950439
ER
PT J
AU Reponen, T
Singh, U
Schaffer, C
Vesper, S
Johansson, E
Adhikari, A
Grinshpun, SA
Indugula, R
Ryan, P
Levin, L
LeMasters, G
AF Reponen, Tiina
Singh, Umesh
Schaffer, Chris
Vesper, Stephen
Johansson, Elisabet
Adhikari, Atin
Grinshpun, Sergey A.
Indugula, Reshmi
Ryan, Patrick
Levin, Linda
LeMasters, Grace
TI Visually observed mold and moldy odor versus quantitatively measured
microbial exposure in homes
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Endotoxin; (1-3)-beta-D-glucan; Fungi; Polymerase chain reaction; House
dust; Air sampling
ID FUNGAL EXTRACELLULAR POLYSACCHARIDES; RELATIVE MOLDINESS INDEX; IN-HOUSE
DUST; NEW-ORLEANS; ENDOTOXIN CONCENTRATIONS; ALLERGIC SENSITIZATION;
RESPIRATORY ILLNESS; AIRBORNE ENDOTOXIN; HURRICANE-KATRINA; DAMAGED
BUILDINGS
AB The main study objective was to compare different methods for assessing mold exposure in conjunction with an epidemiologic study on the development of children's asthma. Homes of 184 children were assessed for mold by visual observations and dust sampling at child's age 1 (Year 1). Similar assessment supplemented with air sampling was conducted in Year 7. Samples were analyzed for endotoxin, (1-3)-beta-D-glucan, and fungal spores. The Mold Specific Quantitative Polymerase Chain Reaction assay was used to analyze 36 mold species in dust samples, and the Environmental Relative Moldiness Index (ERMI) was calculated. Homes were categorized based on three criteria: I) visible mold damage, 2) moldy odor, and 3) ERMI. Even for homes where families had not moved, Year 7 endotoxin and (1-3)-beta-D-glucan exposures were significantly higher than those in Year 1 (p<0.001), whereas no difference was seen for ERMI (p = 0.78). Microbial concentrations were not consistently associated with visible mold damage categories, but were consistently higher in homes with moldy odor and in homes that had high ERMI. Low correlations between results in air and dust samples indicate different types or durations of potential microbial exposures from dust vs. air. Future analysis will indicate which, if any, of the assessment methods is associated with the development of asthma. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Reponen, Tiina; Singh, Umesh; Schaffer, Chris; Johansson, Elisabet; Adhikari, Atin; Grinshpun, Sergey A.; Indugula, Reshmi; Ryan, Patrick; Levin, Linda; LeMasters, Grace] Univ Cincinnati, Dept Environm Hlth, Cincinnati, OH 45267 USA.
[Vesper, Stephen] US EPA, Cincinnati, OH 45268 USA.
RP Reponen, T (reprint author), Univ Cincinnati, Dept Environm Hlth, POB 670056, Cincinnati, OH 45267 USA.
EM Tiina.Reponen@uc.edu
RI Ryan, Patrick /L-7062-2015
FU US Department of Housing and Urban Development [OHLHH0162-07]; National
Institute of Environmental Health Sciences (NIEHS) [E511170]
FX This study is supported by the US Department of Housing and Urban
Development grant #OHLHH0162-07. The CCAAPS birth cohort study is
supported by National Institute of Environmental Health Sciences (NIEHS)
grant E511170. We thank Osmic Enterprises, Inc. (Cincinnati, OH) for
providing the OLFACT-RL and testing of the home assessment team.
NR 61
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U2 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0048-9697
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD OCT 15
PY 2010
VL 408
IS 22
BP 5565
EP 5574
DI 10.1016/j.scitotenv.2010.07.090
PG 10
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 672UG
UT WOS:000283611800039
PM 20810150
ER
PT J
AU Cerutti, DS
Freddolino, PL
Duke, RE
Case, DA
AF Cerutti, David S.
Freddolino, Peter L.
Duke, Robert E., Jr.
Case, David A.
TI Simulations of a Protein Crystal with a High Resolution X-ray Structure:
Evaluation of Force Fields and Water Models
SO JOURNAL OF PHYSICAL CHEMISTRY B
LA English
DT Article
ID ANDROCTONUS-AUSTRALIS HECTOR; STREPTAVIDIN-BIOTIN COMPLEX; CATION-PI
INTERACTIONS; MOLECULAR-DYNAMICS; HARMONIC-ANALYSIS; LARGE SYSTEMS;
TOXIN-II; POTENTIALS; ENERGETICS; MECHANICS
AB We use classical molecular dynamics and 16 combinations of force fields and water models to simulate a protein crystal observed by room-temperature X-ray diffraction. The high resolution of the diffraction data (0.96 angstrom) and the simplicity of the crystallization solution (nearly pure water) make it possible to attribute any inconsistencies between the crystal structure and our simulations to artifacts of the models rather than inadequate representation of the crystal environment or uncertainty in the experiment. All simulations were extended for 100 its of production dynamics, permitting some long-time scale artifacts of each model to emerge. The most noticeable effect of these artifacts is a model-dependent drift in the unit cell dimensions, which can become as large as 5% in certain force fields; the underlying cause is the replacement of native crystallographic contacts with non-native ones, which can occur with heterogeneity (loss of crystallographic symmetry) in simulations with some force fields. We find that the AMBER FF99SB force field maintains a lattice structure nearest that seen in the X-ray data, and produces the most realistic atomic fluctuations (by comparison to crystallographic B-factors) of all the models tested. We find that the choice of water model has a minor effect in comparison to the choice of protein model. We also identify a number of artifacts that occur throughout all of the simulations: excessive formation of hydrogen bonds or salt bridges between polar groups and loss of hydrophobic interactions. This study is intended as a foundation for future work that will identify individual parameters in each molecular model that can he modified to improve their representations of protein structure and thermodynamics.
C1 [Cerutti, David S.; Case, David A.] State Univ New Jersey, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA.
[Cerutti, David S.; Case, David A.] State Univ New Jersey, BioMaPS Inst, Piscataway, NJ 08854 USA.
[Freddolino, Peter L.] Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA.
[Duke, Robert E., Jr.] Natl Inst Environm Hlth Sci, Struct Biol Lab, Chapel Hill, NC 27709 USA.
RP Cerutti, DS (reprint author), State Univ New Jersey, Dept Chem & Chem Biol, 610 Taylor Rd, Piscataway, NJ 08854 USA.
EM dcerutti@rci.rutgers.edu
FU NIH [RR 12255, RR05969, HL06350]
FX This work was supported by NIH grants RR 12255, RR05969, and HL06350,
and by NSF grant FRG DMR-0804549: supercomputing time was partially
provided by Large Resource Allocation Committee MCA93S028 and ITS HPC
computing resources at UNC-Chapel I hill, D.S.C. amid P.L.F. gratefully
acknowledge Terry P. Lybrand and Klaus Schulten for encouraging
preliminary work on this project.
NR 45
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U1 1
U2 26
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1520-6106
J9 J PHYS CHEM B
JI J. Phys. Chem. B
PD OCT 14
PY 2010
VL 114
IS 40
BP 12811
EP 12824
DI 10.1021/jp105813j
PG 14
WC Chemistry, Physical
SC Chemistry
GA 659DC
UT WOS:000282546200006
PM 20860388
ER
PT J
AU Swartz, CD
King, LC
Nesnow, S
Umbach, DM
Kumar, S
Sikka, H
DeMarini, DM
AF Swartz, Carol D.
King, Leon C.
Nesnow, Stephen
Umbach, David M.
Kumar, Subodh
Sikka, Harish
DeMarini, David M.
TI Mutagenicity, stable DNA adducts, and abasic sites induced in Salmonella
by phenanthro[3,4-b]- and phenanthro[4,3-b] thiophenes, sulfur analogs
of benzo[c]phenanthrene (vol 661, pg 47, 2009)
SO MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
LA English
DT Correction
C1 [Swartz, Carol D.] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA.
[King, Leon C.; Nesnow, Stephen; DeMarini, David M.] US EPA, Div Environm Carcinogenesis, Res Triangle Pk, NC 27711 USA.
[Umbach, David M.] NIEHS, Biostat Branch, NIH, DHHS, Res Triangle Pk, NC 27709 USA.
[Kumar, Subodh; Sikka, Harish] SUNY Coll Buffalo, Environm Toxicol & Chem Lab, Great Lakes Ctr, Buffalo, NY 14222 USA.
RP Swartz, CD (reprint author), Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA.
NR 1
TC 0
Z9 0
U1 0
U2 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0027-5107
J9 MUTAT RES-FUND MOL M
JI Mutat. Res.-Fundam. Mol. Mech. Mutagen.
PD OCT 13
PY 2010
VL 692
IS 1-2
BP 66
EP 66
DI 10.1016/j.mrfmmm.2010.06.005
PG 1
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
GA 676FF
UT WOS:000283894800012
ER
PT J
AU Ward, WO
Swartz, CD
Hanley, NM
DeMarini, DM
AF Ward, William O.
Swartz, Carol D.
Hanley, Nancy M.
DeMarini, David M.
TI Transcriptional characterization of Salmonella TA100 in log and
stationary phase: Influence of growth phase on mutagenicity of MX
SO MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
LA English
DT Article
DE Salmonella; Mutagenicity; Microarray; Growth phase; MX
ID ESCHERICHIA-COLI K-12; GENE-EXPRESSION; STRINGENT RESPONSE; MICROARRAY;
BACTERIA; FIS; TYPHIMURIUM; ADAPTATION; INDUCTION; SURVIVAL
AB The Salmonella mutagenicity assay can be performed using cells that are in different growth phases. Thus, the plate-incorporation assay involves plating stationary-phase cells with the mutagen, after which the cells undergo a brief lag phase and, consequently, are exposed to the mutagen and undergo mutagenesis while in the logarithmic (log) phase. In contrast, a liquid-suspension assay involves exposure of either log-or stationary-phase cells to the mutagen for a specified period of time, sometimes followed by a wash, resulting in the cells growing in medium in the absence of the mutagen. To explore global gene expression in Salmonella, and to test for possible effects of growth phase and transcriptional status on mutagenesis, we performed microarray analysis on cells of Salmonella strain TA100 exposed to the drinking-water mutagen MX in either the log or stationary phase. The genes in functional pathways involving amino acid transport and metabolism and energy metabolism were expressed differentially in log-phase cells, whereas genes in functional pathways involving protein trafficking, cell envelope, and two-component systems using common signal transduction were expressed differentially in stationary-phase cells. More than 90% of the ribosomal-protein biosynthesis genes were up-regulated in stationary- versus log-phase cells. MX was equally mutagenic to cells in log- and stationary-phase growth when the results were expressed as mutant frequencies (revertants/survivors/mu M), but it was twice as mutagenic in stationary-phase cells when the results were expressed as mutant yields (revertants/nmole or revertants/mu M). There was a complex transcriptional response underlying these results, with mucA/B being greatly up-regulated in log-phase cells but umuC/D up-regulated in stationary-phase cells. The transcriptional state of TA100 cells at the time of mutagen treatment may influence the outcome of mutagen treatment. Published by Elsevier B.V.
C1 [Ward, William O.; Hanley, Nancy M.; DeMarini, David M.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Swartz, Carol D.] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA.
RP DeMarini, DM (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
EM demarini.david@epa.gov
FU National Health and Environmental Effects Research Laboratory of the
U.S. Environmental Protection Agency; NHEERI-DESE [U.S. EPA CT-82651301]
FX We thank Dr. Robert Franzen, Tampere Institute of Technology, Tampere,
Finland, for providing the MX; Peggy Matthews for media preparation; and
Drs. Susan Hester and Stephen Edwards for their comments on this
manuscript. This work was supported by the intramural research program
within the National Health and Environmental Effects Research Laboratory
of the U.S. Environmental Protection Agency. Dr. Carol Swartz
acknowledges support from the NHEERI-DESE Cooperative Training Agreement
in Environmental Science Research; Grant Number U.S. EPA CT-82651301.
This manuscript was reviewed by the National Health and Environmental
Effects Research Laboratory, U.S. Environmental Protection Agency, and
approved for publication. Approval does not signify that the contents
necessarily reflect the views and policies of the Agency, nor does
mention of trade names or commercial products constitute endorsement or
recommendation for use.
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PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0027-5107
J9 MUTAT RES-FUND MOL M
JI Mutat. Res.-Fundam. Mol. Mech. Mutagen.
PD OCT 13
PY 2010
VL 692
IS 1-2
BP 19
EP 25
DI 10.1016/j.mrfmmm.2010.07.010
PG 7
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
GA 676FF
UT WOS:000283894800004
PM 20691712
ER
PT J
AU Matsuoka, T
Adair, JE
Lih, FB
Hsi, LC
Rubino, M
Eling, TE
Tomer, KB
Yashiro, M
Hirakawa, K
Olden, K
Roberts, JD
AF Matsuoka, T.
Adair, J. E.
Lih, F. B.
Hsi, L. C.
Rubino, M.
Eling, T. E.
Tomer, K. B.
Yashiro, M.
Hirakawa, K.
Olden, K.
Roberts, J. D.
TI Elevated dietary linoleic acid increases gastric carcinoma cell invasion
and metastasis in mice
SO BRITISH JOURNAL OF CANCER
LA English
DT Article
DE gastric carcinoma; dietary fatty acid; cyclooxygenase; metastasis;
invasion
ID POLYUNSATURATED FATTY-ACIDS; PROTEIN-KINASE-C; BREAST-CANCER CELLS;
NUDE-MICE; TUMOR-CELLS; DOCOSAHEXAENOIC ACID; IV COLLAGEN; IN-VITRO;
GROWTH; ADHESION
AB BACKGROUND: Dietary (n-6)-polyunsaturated fatty acids influence cancer development, but the mechanisms have not been well characterised in gastric carcinoma.
METHODS: We used two in vivo models to investigate the effects of these common dietary components on tumour metastasis. In a model of experimental metastasis, immunocompromised mice were fed diets containing linoleic acid (LA) at 2% (LLA), 8% (HLA) or 12% (VHLA) by weight and inoculated intraperitoneally (i.p.) with human gastric carcinoma cells (OCUM-2MD3). To model spontaneous metastasis, OCUM-2MD3 tumours were grafted onto the stomach walls of mice fed with the different diets. In in vitro assays, we investigated invasion and ERK phosphorylation of OCUM-2MD3 cells in the presence or absence of LA. Finally, we tested whether a cyclooxygenase (COX) inhibitor, indomethacin, could block peritoneal metastasis in vivo.
RESULTS: Both the HLA and VHLA groups showed increased incidence of tumour nodules (LA: 53%; HLA: 89%; VHLA: 100%; P<0.03); the VHLA group also displayed increased numbers of tumour nodules and higher total volume relative to LLA group in experimental metastasis model. Both liver invasion (78%) and metastasis to the peritoneal cavity (67%) were more frequent in VHLA group compared with the LLA group (22% and 11%, respectively; P<0.03) in spontaneous metastasis model. We also found that the invasive ability of these cells is greatly enhanced when exposed to LA in vitro. Linoleic acid also increased invasion of other scirrhous gastric carcinoma cells, OCUM-12, NUGC3 and MKN-45. Linoleic acid effect on OCUM-2MD3 cells seems to be dependent on phosphorylation of ERK. The data suggest that invasion and phosphorylation of ERK were dependent on COX. Indomethacin decreased the number of tumours and total tumour volume in both LLA and VHLA groups. Finally, COX-1, which is known to be an important enzyme in the generation of bioactive metabolites from dietary fatty acids, appears to be responsible for the increased metastatic behaviour of OCUM-2MD3 cells in the mouse model.
CONCLUSION: Dietary LA stimulates invasion and peritoneal metastasis of gastric carcinoma cells through COX-catalysed metabolism and activation of ERK, steps that compose pathway potentially amenable to therapeutic intervention. British Journal of Cancer (2010) 103, 1182-1191. doi:10.1038/sj.bjc.6605881 www.bjcancer.com Published online 14 September 2010 (C) 2010 Cancer Research UK
C1 [Matsuoka, T.; Adair, J. E.; Hsi, L. C.; Rubino, M.; Eling, T. E.; Olden, K.; Roberts, J. D.] Natl Inst Environm Hlth Sci, Mol Carcinogenesis Lab, NIH, Res Triangle Pk, NC 27709 USA.
[Matsuoka, T.; Yashiro, M.; Hirakawa, K.] Osaka City Univ, Grad Sch Med, Dept Surg Oncol, Abeno Ku, Osaka 5458585, Japan.
[Lih, F. B.; Tomer, K. B.] Natl Inst Environm Hlth Sci, Struct Biol Lab, NIH, Res Triangle Pk, NC 27709 USA.
RP Matsuoka, T (reprint author), Natl Inst Environm Hlth Sci, Mol Carcinogenesis Lab, NIH, Res Triangle Pk, NC 27709 USA.
EM tskmtsk@aol.com
RI Tomer, Kenneth/E-8018-2013
FU NIH; NIEHS
FX We thank Drs Ron Cannon, Robert Langenbach and Rajendra Chhabra of NIEHS
for a critical analysis of the paper and Dr Shyamal D Peddada for help
with statistical analysis. This study was supported by the Intramural
Research Program of the NIH and NIEHS.
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U1 0
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PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0007-0920
J9 BRIT J CANCER
JI Br. J. Cancer
PD OCT 12
PY 2010
VL 103
IS 8
BP 1182
EP 1191
DI 10.1038/sj.bjc.6605881
PG 10
WC Oncology
SC Oncology
GA 671WL
UT WOS:000283542900007
PM 20842125
ER
PT J
AU Achenbaum, W
Moody, H
Sykes, KE
Kingson, E
AF Achenbaum, W.
Moody, H.
Sykes, K. E.
Kingson, E.
TI WHAT LEGACIES SHOULD BOOMERS LEAVE?
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [Achenbaum, W.] Univ Houston, Houston, TX USA.
[Moody, H.] AARP, Washington, DC USA.
[Sykes, K. E.] EPA, Washington, DC USA.
[Kingson, E.] Syracuse Univ, Syracue, NY USA.
NR 0
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U1 0
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2010
VL 50
SU 1
BP 386
EP 386
PG 1
WC Gerontology
SC Geriatrics & Gerontology
GA 703UL
UT WOS:000286006703089
ER
PT J
AU Ihlaseh, S
Bailey, K
Hester, S
Rosen, M
Jones, C
Ren, H
Cardoso, A
Oliveira, M
Wolf, D
Camargo, JLV
AF Ihlaseh, S.
Bailey, K.
Hester, S.
Rosen, M.
Jones, C.
Ren, H.
Cardoso, A.
Oliveira, M.
Wolf, D.
Camargo, J. L. V.
TI Transcriptional profile of diuron-induced toxicity on the urinary
bladder of male wistar rats to inform mode of action
SO HISTOPATHOLOGY
LA English
DT Meeting Abstract
CT 28th International Congress of the International-Academy-of-Pathology
CY OCT 10-15, 2010
CL Sao Paulo, BRAZIL
SP Int Acad Pathol
C1 UNESP, Lab TOXICAM, Dept Patol, Fac Med Botucatu, Botucatu, SP, Brazil.
US EPA, NHEERL, ORD, Res Triangle Pk, NC USA.
NR 0
TC 0
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U1 0
U2 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0309-0167
J9 HISTOPATHOLOGY
JI Histopathology
PD OCT
PY 2010
VL 57
SU 1
MA 206
BP 75
EP 75
PG 1
WC Cell Biology; Pathology
SC Cell Biology; Pathology
GA 656GW
UT WOS:000282317400206
ER
PT J
AU Klein, M
Brown, L
Tucker, RW
Ashbolt, NJ
Stuetz, RM
Roser, DJ
AF Klein, Marcus
Brown, Leearna
Tucker, Robyn W.
Ashbolt, Nicholas J.
Stuetz, Richard M.
Roser, David J.
TI Diversity and Abundance of Zoonotic Pathogens and Indicators in Manures
of Feedlot Cattle in Australia
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID REAL-TIME PCR; POLYMERASE-CHAIN-REACTION; ENVIRONMENTAL-SAMPLES;
QUANTITATIVE PCR; FECES; WASTE; QUANTIFICATION; WATER; CAMPYLOBACTER;
PREVALENCE
AB The occurrence of 10 pathogens and three fecal indicators was assessed by quantitative PCR in manures of Australian feedlot cattle. Most samples tested positive for one or more pathogens. For the dominant pathogens Campylobacter jejuni, Listeria monocytogenes, Giardia spp., Cryptosporidium spp., and eaeA-positive Escherichia coli, 10(2) to 10(7) genome copies g(-1) (dry weight) manure were recovered.
C1 [Klein, Marcus; Brown, Leearna; Ashbolt, Nicholas J.; Stuetz, Richard M.; Roser, David J.] Univ New S Wales, Sch Civil & Environm Engn, UNSW Water Res Ctr, Sydney, NSW 2052, Australia.
[Tucker, Robyn W.] Feedlot Serv Australia Pty Ltd FSA Consulting, Toowoomba, Qld 4350, Australia.
[Ashbolt, Nicholas J.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
RP Klein, M (reprint author), Univ New S Wales, Sch Civil & Environm Engn, UNSW Water Res Ctr, Sydney, NSW 2052, Australia.
EM mklein@unsw.edu.au
FU Meat and Livestock Australia (MLA)
FX This work was supported by Meat and Livestock Australia (MLA). We
express our thanks to Feedlot Services Australia Pty. Ltd. (FSA
Consulting) for their contribution in field work and also thank Richard
Whittington (University of Sydney) and Scott Craig (Leptospirosis
Reference Centre, Brisbane) for kindly providing DNA references.
NR 29
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U1 0
U2 6
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD OCT
PY 2010
VL 76
IS 20
BP 6947
EP 6950
DI 10.1128/AEM.01095-10
PG 4
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA 659VM
UT WOS:000282595100032
PM 20802080
ER
PT J
AU Tao, J
Huggins, D
Welker, G
Dias, JR
Ingersoll, CG
Murowchick, JB
AF Tao, J.
Huggins, D.
Welker, G.
Dias, J. R.
Ingersoll, C. G.
Murowchick, J. B.
TI Sediment Matrix Effects in Analysis of Pyrethroid Insecticides Using Gas
Chromatography-Mass Spectrometry
SO ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
LA English
DT Article
ID POLYCYCLIC AROMATIC-HYDROCARBONS; GRAND-CALUMET RIVER; NEWARK BAY
ESTUARY; UNITED-STATES; ORGANOCHLORINE PESTICIDES; ORGANIC POLLUTANTS;
NEW-JERSEY; TOXICITY; PAHS; SOIL
AB In the present study, we developed a gas chromatography-quadrupole mass spectrometry method for analyzing nine pyrethroid insecticides in sediment after accelerated solvent extraction and solid phase extraction cleanup. The operation was optimized, and negative chemical ionization was selected to improve analytical selectivity. The sediment matrix effects on qualification were evaluated, and matrix-matched standard solutions, along with the internal standard calibration, were used to reduce the matrix-induced chromatographic response enhancement. The method detection limits were 0.68 to 1.43 mu g/kg dry weight (dw), and recoveries were 70.3 to 143.3%, 61.1 to 169.7%, and 65.7 to 118.8%, with relative SDs of 4.2% to 32.1%, 4.9 to 23.6%, and 1.5 to 23.3% at the spiked levels of 1.0, 5.0 and 20 mu g/kg dw, respectively. The method was also validated by measuring pyrethroids in field-contaminated sediment samples collected in central California and southern Illinois.
C1 [Tao, J.] Water Serv Dept, Kansas City, MO 64130 USA.
[Tao, J.; Murowchick, J. B.] Univ Missouri, Dept Geosci, Kansas City, MO 64110 USA.
[Tao, J.; Dias, J. R.] Univ Missouri, Dept Chem, Kansas City, MO 64110 USA.
[Huggins, D.] Univ Kansas, Cent Plains Ctr BioAssessment, Lawrence, KS 66047 USA.
[Welker, G.] US Environm Protect Agcy Reg 7, Environm Serv Sect, Kansas City, KS 66101 USA.
[Ingersoll, C. G.] US Geol Survey, Columbia Environm Res Ctr, Columbia, MO 65201 USA.
RP Tao, J (reprint author), Water Serv Dept, 4800 E 63rd St, Kansas City, MO 64130 USA.
EM jing_tao@kcmo.org
OI Murowchick, James/0000-0003-2987-0352
FU U.S. Environmental Protection Agency (EPA), Region 7, in Kansas City,
Kansas; Geological Society of America; University of Missouri-Kansas
City (UMKC) School of Graduate Studies and Women's Council
FX This study was funded in part by the U.S. Environmental Protection
Agency (EPA), Region 7, in Kansas City, Kansas, by a Geological Society
of America Graduate Research Grant, and by the University of
Missouri-Kansas City (UMKC) School of Graduate Studies and Women's
Council. We thank the Organic Chemistry Laboratory and the Nutrients
Laboratory of EPA Region 7 for chemical analyses of sediment samples.
Marchin Lawrence from the same agency is kindly acknowledged for
coordinating laboratory work. Thanks are also due to Scott Ireland, with
the EPA Great Lakes National Program Office, Venessa Madden, with EPA
Region 7, and four other anonymous reviewers for their helpful review
comments on this paper. Any use of trade, product, or firm names is for
descriptive purposes only and does not imply endorsement by the U.S.
Government.
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PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0090-4341
J9 ARCH ENVIRON CON TOX
JI Arch. Environ. Contam. Toxicol.
PD OCT
PY 2010
VL 59
IS 3
BP 352
EP 369
DI 10.1007/s00244-010-9497-2
PG 18
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 644KR
UT WOS:000281376500002
PM 20390412
ER
PT J
AU Tao, J
Ingersoll, CG
Kemble, NE
Dias, JR
Murowchick, JB
Welker, G
Huggins, D
AF Tao, J.
Ingersoll, C. G.
Kemble, N. E.
Dias, J. R.
Murowchick, J. B.
Welker, G.
Huggins, D.
TI Sediment Contamination of Residential Streams in the Metropolitan Kansas
City Area, USA: Part II. Whole-Sediment Toxicity to the Amphipod
Hyalella azteca
SO ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
LA English
DT Article
ID POLYCYCLIC AROMATIC-HYDROCARBONS; GRAND-CALUMET RIVER; QUALITY
GUIDELINES; INDIANA
AB This is the second part of a study that evaluates the influence of nonpoint sources on the sediment quality of five adjacent streams within the metropolitan Kansas City area, central United States. Physical, chemical, and toxicity data (Hyalella azteca 28-day whole-sediment toxicity test) for 29 samples collected in 2003 were used for this evaluation, and the potential causes for the toxic effects were explored. The sediments exhibited a low to moderate toxicity, with five samples identified as toxic to H. azteca. Metals did not likely cause the toxicity based on low concentrations of metals in the pore water and elevated concentrations of acid volatile sulfide in the sediments. Although individual polycyclic aromatic hydrocarbons (PAHs) frequently exceeded effect-based sediment quality guidelines [probable effect concentrations (PECs)], only four of the samples had a PEC quotient (PEC-Q) for total PAHs over 1.0 and only one of these four samples was identified as toxic. For the mean PEC-Q for organochlorine compounds (chlordane, dieldrin, sum DDEs), 4 of the 12 samples with a mean PEC-Q above 1.0 were toxic and 4 of the 8 samples with a mean PEC-Q above 3.0 were toxic. Additionally, four of eight samples were toxic, with a mean PEC-Q above 1.0 based on metals, PAHs, polychlorinated biphenyls (PCBs), and organochlorine pesticides. The increase in the incidence of toxicity with the increase in the mean PEC-Q based on organochlorine pesticides or based on metals, PAHs, PCBs, and organochlorine pesticides suggests that organochlorine pesticides might have contributed to the observed toxicity and that the use of a mean PEC-Q, rather than PEC-Qs for individual compounds, might be more informative in predicting toxic effects. Our study shows that stream sediments subject to predominant nonpoint sources contamination can be toxic and that many factors, including analysis of a full suite of PAHs and pesticides of both past and present urban applications and the origins of these organic compounds, are important to identify the causes of toxicity.
C1 [Tao, J.; Dias, J. R.] Univ Missouri, Dept Chem, Kansas City, MO 64110 USA.
[Ingersoll, C. G.; Kemble, N. E.] US Geol Survey, Columbia Environm Res Ctr, Columbia, MO 65201 USA.
[Welker, G.] US Environm Protect Agcy Reg 7, Environm Serv Sect, Kansas City, KS 66101 USA.
[Huggins, D.] Univ Kansas, Cent Plains Ctr BioAssessment, Lawrence, KS 66047 USA.
[Tao, J.; Murowchick, J. B.] Univ Missouri, Dept Geosci, Kansas City, MO 64110 USA.
RP Tao, J (reprint author), Water Serv Dept, 4800 E 63rd St, Kansas City, MO 64130 USA.
EM jing_tao@kcmo.org
OI Murowchick, James/0000-0003-2987-0352
FU US Environmental Protection Agency-Region 7 in Kansas City, Kansas;
Geological Society of America
FX This study has been funded in part by the US Environmental Protection
Agency-Region 7 in Kansas City, Kansas and by a Geological Society of
America Graduate Research Grant. We would like to thank the members of
the Toxicology Branch of the Columbia Environmental Research Center, US
Geological Survey, Columbia, Missouri for assistance in conducting the
toxicity tests and measuring grain size. We thank the Organic Chemistry
Laboratory and the Nutrients Laboratory of the EPA Region 7 for chemical
analysis of whole-sediment samples. Marchin Lawrence from the same
agency is kindly acknowledged for coordinating laboratory work. We are
also grateful to Scott Ireland with the EPA Great Lakes National Program
Office, Venessa Madden with the EPA Region 7, and four other anonymous
reviewers for their constructive review comments on this manuscript. Any
use of trade, product, or firm names is for descriptive purposes only
and does not imply endorsement by the US government.
NR 36
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PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0090-4341
J9 ARCH ENVIRON CON TOX
JI Arch. Environ. Contam. Toxicol.
PD OCT
PY 2010
VL 59
IS 3
BP 370
EP 381
DI 10.1007/s00244-010-9498-1
PG 12
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 644KR
UT WOS:000281376500003
PM 20396875
ER
PT J
AU Rao, ST
AF Rao, S. Trivikrama
TI Special Issue: Air Quality Modeling and Analysis
SO ATMOSPHERIC POLLUTION RESEARCH
LA English
DT Editorial Material
C1 US EPA, Off Res & Dev, Natl Exposure Res Lab, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA.
RP Rao, ST (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA.
NR 0
TC 0
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U1 0
U2 0
PU TURKISH NATL COMMITTEE AIR POLLUTION RES & CONTROL-TUNCAP
PI BUCA
PA DOKUZ EYLUL UNIV, DEPT ENVIRONMENTAL ENGINEERING, TINAZTEPE CAMPUS,
BUCA, IZMIR 35160, TURKEY
SN 1309-1042
J9 ATMOS POLLUT RES
JI Atmos. Pollut. Res.
PD OCT
PY 2010
VL 1
IS 4
SI SI
BP 195
EP 195
DI 10.5094/APR.2010.025
PG 1
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA V25XF
UT WOS:000208510000001
ER
PT J
AU Simon, H
Beck, L
Bhave, PV
Divita, F
Hsu, Y
Luecken, D
Mobley, JD
Pouliot, GA
Reff, A
Sarwar, G
Strum, M
AF Simon, Heather
Beck, Lee
Bhave, Prakash V.
Divita, Frank
Hsu, Ying
Luecken, Deborah
Mobley, J. David
Pouliot, George A.
Reff, Adam
Sarwar, Golam
Strum, Madeleine
TI The development and uses of EPA's SPECIATE database
SO ATMOSPHERIC POLLUTION RESEARCH
LA English
DT Article
DE SPECIATE; Emissions; VOC; Particulate matter; Speciation profiles
AB SPECIATE is the U.S. Environmental Protection Agency's (EPA) repository of volatile organic compounds (VOCs) and particulate matter (PM) speciation profiles of air pollution sources. These source profiles can be used to (1) provide input to chemical mass balance (CMB) receptor models; (2) verify profiles derived from ambient measurements by multivariate receptor models (e.g., factor analysis and positive matrix factorization); (3) interpret ambient measurement data; and (4) create speciated emission inventories for regional haze, climate, and photochemical air quality modeling. This paper describes the SPECIATE v4.2 database, provides specific examples of its use, and makes recommendations for future improvements. (C) Author(s) 2010. This work is distributed under the Creative Commons Attribution 3.0 License.
C1 [Simon, Heather; Bhave, Prakash V.; Luecken, Deborah; Mobley, J. David; Pouliot, George A.; Sarwar, Golam] US EPA, Natl Exposure Res Lab, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA.
[Beck, Lee] US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
[Divita, Frank; Hsu, Ying] EH Pechan & Associates, Springfield, VA 22151 USA.
[Reff, Adam; Strum, Madeleine] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
RP Simon, H (reprint author), US EPA, Natl Exposure Res Lab, Atmospher Modeling & Anal Div, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM simon.heather@epa.gov
RI Bhave, Prakash/L-1958-2013; Xiongfei, Zhao/G-7690-2015; simon,
heather/E-4392-2011;
OI Bhave, Prakash/0000-0002-2573-951X; simon, heather/0000-0001-7254-3360;
Pouliot, George/0000-0003-3406-4814
FU United States Environmental Protection Agency through its Office of
Research and Development
FX The authors would like to thank Bill Lonneman, Doug Solomon, Joe Somers,
and Tom Pierce from the US EPA for their helpful feedback on this work.
The United States Environmental Protection Agency through its Office of
Research and Development funded and managed the research described here.
It has been subjected to Agency's administrative review and approved for
publication.
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PU TURKISH NATL COMMITTEE AIR POLLUTION RES & CONTROL-TUNCAP
PI BUCA
PA DOKUZ EYLUL UNIV, DEPT ENVIRONMENTAL ENGINEERING, TINAZTEPE CAMPUS,
BUCA, IZMIR 35160, TURKEY
SN 1309-1042
J9 ATMOS POLLUT RES
JI Atmos. Pollut. Res.
PD OCT
PY 2010
VL 1
IS 4
SI SI
BP 196
EP 206
DI 10.5094/APR.2010.026
PG 11
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA V25XF
UT WOS:000208510000002
ER
PT J
AU Dennis, RL
Mathur, R
Pleim, JE
Walker, JT
AF Dennis, Robin L.
Mathur, Rohit
Pleim, Jonathan E.
Walker, John T.
TI Fate of ammonia emissions at the local to regional scale as simulated by
the Community Multiscale Air Quality model
SO ATMOSPHERIC POLLUTION RESEARCH
LA English
DT Article
DE Ammonia deposition; Ammonia emission influence range; Atmospheric
budget; Modeling; CMAQ
AB Atmospheric deposition of nitrogen contributes to eutrophication of estuarine waters and acidification of lakes and streams. Ammonia also contributes to fine particle formation in the atmosphere and associated health effects. Model projections suggest that NH3 deposition may become the major source of nitrogen deposition in the future. The regional transport of NH3 contributes to nitrogen deposition. Conventional wisdom for many is that a large fraction, or even all, of the NH3 emissions deposit locally, near their source as dry deposition, which we believe is incorrect. In this study we use a regional atmospheric model, the Community Multiscale Air Quality (CMAQ) model to identify the dominant processes that dictate the fate of NH3 and address the questions of how much NH3 deposits locally and what is the range of influence of NH3 emissions. The CMAQ simulation is for June 2002 with a 12-km grid size, covering the eastern half of the U.S. We study three different NH3 dry deposition formulations, including one that represents bi-directional NH3 air-surface exchange, to represent uncertainty in the NH3 dry deposition estimates. We find for 12-km cells with high NH3 emissions from confined animal operations that the local budget is dominated by turbulent transport away from the surface and that from 8-15% of a cell's NH3 emissions dry deposit locally back within the same cell. The CMAQ estimates are consistent with local, semi-empirical budget studies of NH3 emissions. The range of influence of a single cell's emissions varies from 180 to 380 kilometers, depending on the dry deposition formulation. At the regional scale, wet deposition is the major loss pathway for NH3; nonetheless, about a quarter of the NH3 emissions are estimated to transport off the North American continent, an estimate that is not sensitive to the uncertainty in dry deposition. (C) Author(s) 2010. This work is distributed under the Creative Commons Attribution 3.0 License.
C1 [Dennis, Robin L.; Mathur, Rohit; Pleim, Jonathan E.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Walker, John T.] US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
RP Dennis, RL (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
EM dennis.robin@epa.gov
RI Walker, John/I-8880-2014; Pleim, Jonathan Pleim/C-1331-2017
OI Walker, John/0000-0001-6034-7514; Pleim, Jonathan
Pleim/0000-0001-6190-6082
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U2 21
PU TURKISH NATL COMMITTEE AIR POLLUTION RES & CONTROL-TUNCAP
PI BUCA
PA DOKUZ EYLUL UNIV, DEPT ENVIRONMENTAL ENGINEERING, TINAZTEPE CAMPUS,
BUCA, IZMIR 35160, TURKEY
SN 1309-1042
J9 ATMOS POLLUT RES
JI Atmos. Pollut. Res.
PD OCT
PY 2010
VL 1
IS 4
SI SI
BP 207
EP 214
DI 10.5094/APR.2010.027
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA V25XF
UT WOS:000208510000003
ER
PT J
AU Wesson, K
Fann, N
Morris, M
Fox, T
Hubbell, B
AF Wesson, Karen
Fann, Neal
Morris, Mark
Fox, Tyler
Hubbell, Bryan
TI A multi-pollutant, risk-based approach to air quality management: Case
study for Detroit
SO ATMOSPHERIC POLLUTION RESEARCH
LA English
DT Article
DE Multi-pollutant; Control strategy; Risk; Benefits; Air quality
management
AB In response to the need to further explore and understand the technical needs and challenges presented by implementing a multi-pollutant, risk-based approach to air quality management, a case study was performed for the urban area of Detroit. As part of this case study, two contrasting air quality control strategies were assessed and compared. One strategy mimicked the "status quo", where controls were selected separately to address ozone (O-3) and fine particulate matter (PM2.5) nonattainment at monitor locations, while the other strategy reflected a "multi-pollutant, risk-based" approach aimed at further reducing population risk from exposure to ozone, PM2.5 and selected air toxics while still addressing ozone and PM2.5 nonattainment. This paper describes the technical framework used to apply and evaluate the two contrasting air quality control strategies and describes the relative benefits of each. Based on this case study, we found that the "multi-pollutant, risk-based" approach was able to: (1) achieve the same or greater reductions of PM2.5 and O-3 at monitors; (2) improve air quality regionally and across the Detroit urban core for multiple pollutants; (3) produce approximately two times greater monetized benefits for PM2.5 and O-3; (4) reduce non-cancer risk; and (5) result in greater net benefits and be more cost effective. (C) Author(s) 2010. This work is distributed under the Creative Commons Attribution 3.0 License.
C1 [Wesson, Karen; Fann, Neal; Morris, Mark; Fox, Tyler; Hubbell, Bryan] US Environm Protect Agcy, Res Triangle Pk, NC USA.
RP Wesson, K (reprint author), US Environm Protect Agcy, Res Triangle Pk, NC USA.
EM wesson.karen@epa.gov
OI Fann, Neal/0000-0002-6724-8575; Hubbell, Bryan/0000-0002-7963-3438
NR 29
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U1 0
U2 14
PU TURKISH NATL COMMITTEE AIR POLLUTION RES & CONTROL-TUNCAP
PI BUCA
PA DOKUZ EYLUL UNIV, DEPT ENVIRONMENTAL ENGINEERING, TINAZTEPE CAMPUS,
BUCA, IZMIR 35160, TURKEY
SN 1309-1042
J9 ATMOS POLLUT RES
JI Atmos. Pollut. Res.
PD OCT
PY 2010
VL 1
IS 4
SI SI
BP 296
EP 304
DI 10.5094/APR.2010.037
PG 9
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA V25XF
UT WOS:000208510000013
ER
PT J
AU Miller, DH
Kreis, RG
Huang, WC
Xia, XS
AF Miller, David H.
Kreis, Russell G., Jr.
Huang, Wei-Chuang
Xia, Xiangsheng
TI Application of a lower food web ecosystem productivity model for
investigating dynamics of the invasive species Bythotrephes longimanus
in Lake Michigan
SO BIOLOGICAL INVASIONS
LA English
DT Article
DE Invasive species; Bythotrephes longimanus; Zooplankton; Ecosystem
productivity model
ID GREAT-LAKES; BIODIVERSITY; INVERTEBRATE; COMMUNITIES; BAY
AB A Lake Michigan Ecosystem Model (LM-Eco) that includes a detailed description of trophic levels and their interactions was developed for Lake Michigan. The LM-Eco model constitutes a first step toward a comprehensive Lake Michigan ecosystem productivity model to investigate ecosystem-level responses and effects within the lower food web of the lake. The effect of the invasive species Bythotrephes longimanus on individual zooplankton species was investigated based upon extensive field data collected at multiple locations in Lake Michigan during the 1994-1995 Lake Michigan Mass Balance Study. Field data collected at 15 sampling stations within Lake Michigan over a series of 8 sampling cruises throughout a 2 year period demonstrated that over 65% of zooplankton species exhibited a decline with the occurrence of Bythotrephes in the sample. The LM-Eco model was successfully applied to simulate the trends of Bythotrephes and zooplankton abundance as observed in the collected field data. Model simulations allowed for examination of interactions between the invader Bythotrephes and native zooplankton groups on a 5 km by 5 km resolution throughout Lake Michigan. Analysis was completed as a time series specific to individual field sampling locations within the lake, and also on a lake-wide scale.
C1 [Miller, David H.; Kreis, Russell G., Jr.] US EPA, Mid Continent Ecol Div, ORD, NHEERL,Res Stn, Grosse Ile, MI 48138 USA.
[Huang, Wei-Chuang] USN, Res Lab, Geothermal Program Off, China Lake, CA 93555 USA.
[Xia, Xiangsheng] CSC Corp, Grosse Ile, MI 48138 USA.
RP Miller, DH (reprint author), US EPA, Mid Continent Ecol Div, ORD, NHEERL,Res Stn, 9311 Groh, Grosse Ile, MI 48138 USA.
EM miller.davidh@epa.gov
FU Invasive Species Initiative in the Office of Research and Development
(ORD) of the USEPA
FX This study was conducted in support of the Invasive Species Initiative
in the Office of Research and Development (ORD) of the USEPA. We thank
Peder Yurista and Henry Vanderploeg for providing a valuable review of
this manuscript. The authors also wish to acknowledge the Great Lakes
National Program Office for their efforts in the Lake Michigan Mass
Balance Study, as well as the many cooperators during the study. In
addition, the authors wish to acknowledge NOAA, GLERL, and LimnoTech for
their cooperation and collaboration. The views expressed in this article
are those of the authors and do not necessarily reflect the views or
policies of the U. S. Environmental Protection Agency. Mention of trade
names or commercial products does not constitute endorsement or
recommendation for use.
NR 41
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U1 2
U2 15
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1387-3547
J9 BIOL INVASIONS
JI Biol. Invasions
PD OCT
PY 2010
VL 12
IS 10
BP 3513
EP 3524
DI 10.1007/s10530-010-9748-1
PG 12
WC Biodiversity Conservation; Ecology
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 652CA
UT WOS:000281977200013
ER
PT J
AU More, TT
Yan, S
Tyagi, RD
Surampalli, RY
AF More, T. T.
Yan, S.
Tyagi, R. D.
Surampalli, R. Y.
TI Potential use of filamentous fungi for wastewater sludge treatment
SO BIORESOURCE TECHNOLOGY
LA English
DT Review
DE Filamentous fungi; Sludge settling and dewatering; Degradation; Pathogen
removal; Detoxification
ID STATE BIOCONVERSION PROCESS; OIL MILL EFFLUENTS; WHITE-ROT FUNGI;
ACTIVATED-SLUDGE; SEWAGE-SLUDGE; INDUSTRIAL WASTEWATERS; INTEGRATED
TREATMENT; TRICHODERMA-VIRIDE; ASPERGILLUS-NIGER; DEWATERED SLUDGE
AB Specific filamentous fungi (FF) have been recognized for sludge treatment and possibly these strains can be utilized for simultaneous bioflocculation, solids and pathogens reduction and, removal and degradation of toxic compounds. Based on current research work and findings, this review provides the state-of-art knowledge on the role of FF (or moulds) in sludge treatment. The proposed theories are presented, critically analyzed and future scope for specific research on utilization of FF for treatment of sludge is recommended. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [More, T. T.; Yan, S.; Tyagi, R. D.] Univ Quebec, Inst Natl Rech Sci, Ctr Eau Terre & Environm, Quebec City, PQ G1K 9A9, Canada.
[Surampalli, R. Y.] US EPA, Kansas City, KS 66117 USA.
RP Tyagi, RD (reprint author), Univ Quebec, Inst Natl Rech Sci, Ctr Eau Terre & Environm, 490 Couronne, Quebec City, PQ G1K 9A9, Canada.
EM tyagi@ete.inrs.ca
FU Natural Sciences and Engineering Research Council of Canada [A 4984]
FX Sincere thanks are due to the Natural Sciences and Engineering Research
Council of Canada (Grant A 4984, Canada Research Chair) for their
financial support. The views and opinions expressed in this paper are
those of the authors and should not be construed as the opinions of the
US Environmental Protection Agency.
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U1 6
U2 44
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0960-8524
J9 BIORESOURCE TECHNOL
JI Bioresour. Technol.
PD OCT
PY 2010
VL 101
IS 20
BP 7691
EP 7700
DI 10.1016/j.biortech.2010.05.033
PG 10
WC Agricultural Engineering; Biotechnology & Applied Microbiology; Energy &
Fuels
SC Agriculture; Biotechnology & Applied Microbiology; Energy & Fuels
GA 631IP
UT WOS:000280340300001
PM 20542684
ER
PT J
AU Ellis-Hutchings, RG
Zucker, RM
Grey, BE
Norwood, J
Richards, JH
Lau, C
Rogers, JM
AF Ellis-Hutchings, Robert G.
Zucker, Robert M.
Grey, Brian E.
Norwood, Joel, Jr.
Richards, Judy H.
Lau, Christopher
Rogers, John M.
TI Altered Health Outcomes in Adult Offspring of Sprague Dawley and Wistar
Rats Undernourished During Early or Late Pregnancy
SO BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY
LA English
DT Article
DE embryo/fetal physiology; nutrition; postnatal evaluation; maternal-fetal
interactions
ID INTRAUTERINE GROWTH RESTRICTION; BLOOD-PRESSURE; METABOLIC SYNDROME;
POSTNATAL-GROWTH; BIRTH-WEIGHT; PROTEIN-DIET; INSULIN; HYPERTENSION;
NUTRITION; AXIS
AB BACKGROUND: Birth weight in humans has been inversely associated with adult disease risk. Results of animal studies have varied depending on species, strain, and treatment. METHODS: We compared birth weight and adult health in offspring following 50% maternal undernutrition on gestation days (GD) 1-15 (UN1-15) or GD 10-21 (UN10-21) in Sprague Dawley and Wistar rats. Offspring from food-deprived dams were weighed and cross-fostered to control dams. Litters were weighed during lactation and initiating at weaning males were fed either control or a high-fat diet. Young and mature adult offspring were evaluated for obesity, blood pressure (BP), insulin response to oral glucose, and serum lipids. Nephron endowment, renal glucocorticoid receptor, and renin-aldosterone-angiotensin system components were measured. RESULTS: The UN10-21 groups had birth weights lower than controls and transient catch up growth by weaning. Neither strain demonstrated obesity or dyslipidemia following prenatal undernutrition, but long-term body weight deficits occurred in the UN groups of both strains. High-fat diet fed offspring gained more weight than control offspring without an effect of prenatal nutrition. Sprague Dawley were slightly more susceptible than Wistar rats to altered insulin response and increased BP following gestational undernutrition. Nephron endowment in Sprague Dawley but not Wistar offspring was lower in the UN10-21 groups. Glucocorticoid and renin-aldosterone-angiotensin system pathways were not altered. CONCLUSIONS: The most consistent effect of maternal undernutrition was elevated BP in offspring. Long-term health effects occurred with undernutrition during either window, but the UN10-21 period resulted in lower birth weight and more severe adult health effects. Birth Defects Res (Part B) 89:396-407,2010. (C) 2010 Wiley-Liss, Inc.
C1 [Ellis-Hutchings, Robert G.; Zucker, Robert M.; Grey, Brian E.; Norwood, Joel, Jr.; Lau, Christopher; Rogers, John M.] US EPA, Toxicol Assessment Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Richards, Judy H.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Ellis-Hutchings, RG (reprint author), Dow Chem Co USA, Toxicol & Environm Res & Consulting, 1803 Bldg, Midland, MI 48674 USA.
EM Rellis-hutchings@dow.com
NR 43
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U1 0
U2 6
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1542-9733
J9 BIRTH DEFECTS RES B
JI Birth Defects Res. Part B-Dev. Reprod. Toxicol.
PD OCT
PY 2010
VL 89
IS 5
BP 396
EP 407
DI 10.1002/bdrb.20265
PG 12
WC Oncology; Genetics & Heredity; Toxicology
SC Oncology; Genetics & Heredity; Toxicology
GA 676LB
UT WOS:000283911500005
PM 20973054
ER
PT J
AU Luke, NS
DeVito, MJ
Shah, I
El-Masri, HA
AF Luke, Nicholas S.
DeVito, Michael J.
Shah, Imran
El-Masri, Hisham A.
TI Development of a Quantitative Model of Pregnane X Receptor (PXR)
Mediated Xenobiotic Metabolizing Enzyme Induction
SO BULLETIN OF MATHEMATICAL BIOLOGY
LA English
DT Article
DE Nuclear receptors; Mathematical model; Gene induction
ID CYP3A4 GENE-EXPRESSION; NUCLEAR RECEPTORS; INTERINDIVIDUAL VARIABILITY;
DRUG-INTERACTIONS; LIVER; RIFAMPICIN; TRANSCRIPTION; ACTIVATION;
PATHWAYS; LIGANDS
AB The pregnane X receptor plays an integral role in the regulation of hepatic metabolism. It has been shown to regulate CYP3A4, which is the most abundant cytochrome P450 in the human liver. With its large and flexible ligand-binding domain, PXR can be activated by an enormous range of relatively small, hydrophobic, exogenous compounds. Upon activation, PXR partners with the retinoid X receptor (RXR) to form a heterodimer. The newly formed heterodimer binds to an appropriate DNA response element, causing increased transcription. This leads to an induction in the level of CYP3A4. These mechanistic steps are included into a biologically-based mathematical model. The quantitative model predicts fold level inductions of CYP3A4 mRNA and protein in response to PXR activation. Model parameter values have been taken from literature when appropriate. Unknown parameter values are estimated by optimizing the model results to published in vivo and in vitro data sets. A sensitivity analysis is performed to evaluate the model structure and identify future data needs which would be critical to revising the model.
C1 [Luke, Nicholas S.] N Carolina Agr & Tech State Univ, Dept Math, Greensboro, NC 27411 USA.
[DeVito, Michael J.] NIEHS, Natl Toxicol Program, Res Triangle Pk, NC 27709 USA.
[El-Masri, Hisham A.] US EPA, ORD, NHEERL, Integrated Syst Toxicol Div, Res Triangle Pk, NC 27711 USA.
[Shah, Imran] US EPA, ORD, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA.
RP Luke, NS (reprint author), N Carolina Agr & Tech State Univ, Dept Math, Greensboro, NC 27411 USA.
EM luke@ncat.edu; Michael.Devito@nih.gov; shah.imran@epa.gov;
el-masri.hisham@epa.gov
NR 41
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U1 3
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0092-8240
J9 B MATH BIOL
JI Bull. Math. Biol.
PD OCT
PY 2010
VL 72
IS 7
BP 1799
EP 1819
DI 10.1007/s11538-010-9508-5
PG 21
WC Biology; Mathematical & Computational Biology
SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational
Biology
GA 657QR
UT WOS:000282427900007
PM 20151218
ER
PT J
AU Mohapatra, DP
Brar, SK
Tyagi, RD
Surampalli, RY
AF Mohapatra, D. P.
Brar, S. K.
Tyagi, R. D.
Surampalli, R. Y.
TI Degradation of endocrine disrupting bisphenol A during pre-treatment and
biotransformation of wastewater sludge
SO CHEMICAL ENGINEERING JOURNAL
LA English
DT Article
DE Bisphenol A; Wastewater sludge; Pre-treatment; Rheology; Zeta potential;
Laccase activity
ID ACTIVATED-SLUDGE; ANAEROBIC-DIGESTION; THERMOCHEMICAL PRETREATMENT;
SEWAGE-SLUDGE; LACCASE; BIOFLOCCULATION; BIODEGRADATION; DISINTEGRATION;
SOLUBILIZATION; ENHANCEMENT
AB The effect of various pre-treatment methods, including alkaline hydrolysis (AH), thermal hydrolysis (TH), thermal alkaline hydrolysis (TAN), thermal oxidation (TO) and thermal alkaline oxidation (TAO), on solubilization and simultaneous degradation of bisphenol A (BPA), an endocrine disruptor, in wastewater sludge (WWS) were investigated. The results showed that among AH, TH and TAN pre-treatments, TAH significantly improved the solubilization of WWS (41.6% suspended solid (SS), 70.7% volatile suspended solid (VSS) and 48.5% chemical oxygen demand (COD)) with higher degradation of BPA (38.4%). SS, VSS and COD solubilization were observed to be lower in TO and TAO pre-treatment as compared to TAN pre-treatment. However, higher degradation of BPA (75.0% and 78.9%) was observed in TO and TAO pre-treatment clue to the presence of oxidation process. The effects of rheology and zeta potential on degradation of BPA in raw sludge and different pre-treated sludges were also investigated. The results showed that decrease in viscosity and particle size and increase in zeta potential resulted in higher degradation of BPA. BPA degradation by laccases produced by Sinorhizobium meliloti in raw and pre-treated sludge was also determined. Higher activity of laccases (230.9 U L(-1)) was observed in TAH pre-treated sludge resulting in high degradation of BPA (21.9%) suggesting concomitant biological degradation of BPA. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Mohapatra, D. P.; Brar, S. K.; Tyagi, R. D.] Univ Quebec, INRS ETE, Quebec City, PQ G1K 9A9, Canada.
[Surampalli, R. Y.] US EPA, Kansas City, KS 66117 USA.
RP Brar, SK (reprint author), Univ Quebec, INRS ETE, 490 Rue Couronne, Quebec City, PQ G1K 9A9, Canada.
EM satinder.brar@ete.inrs.ca
FU Natural Sciences and Engineering Research Council of Canada [A4984,
355254, STP235071]; INRS-ETE
FX The authors are sincerely thankful to the Natural Sciences and
Engineering Research Council of Canada (Discovery Grants A4984 and
355254, STP235071, Canada Research Chair) and INRS-ETE for financial
support. The views or opinions expressed in this article are those of
the authors and should not be construed as opinions of the U.S.
Environmental Protection Agency.
NR 38
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U1 2
U2 38
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 1385-8947
J9 CHEM ENG J
JI Chem. Eng. J.
PD OCT 1
PY 2010
VL 163
IS 3
BP 273
EP 283
DI 10.1016/j.cej.2010.07.062
PG 11
WC Engineering, Environmental; Engineering, Chemical
SC Engineering
GA 670TE
UT WOS:000283449400014
ER
PT J
AU Owens, EO
AF Owens, Elizabeth Oesterling
TI Endogenous carbon monoxide production in disease
SO CLINICAL BIOCHEMISTRY
LA English
DT Review
DE Endogenous carbon monoxide; Heme oxygenase; Carboxyhemoglobin
ID INFLAMMATORY PULMONARY-DISEASES; MICROSOMAL HEME OXYGENASE;
CRITICALLY-ILL PATIENTS; SICKLE-CELL-DISEASE; CARBOXYHEMOGLOBIN LEVELS;
EXHALED AIR; OXIDATIVE STRESS; ARTERIAL CARBOXYHEMOGLOBIN; ERYTHROCYTE
DESTRUCTION; BIOLOGICAL-SYSTEMS
AB Carbon monoxide (CO) in tissues and cells can originate from inhalation of CO or endogenously. Endogenous production, carboxyhemoglobin (COHb) formation, and exhaled CO levels are influenced by physiological factors, including disease. It is suggested that endogenous CO production can be used as a biomarker for oxidative and inflammatory processes. Also, endogenous CO can contribute to increased body burden of CO, which may both disrupt normal CO signaling cascades and increase the risk of CO toxicity. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
C1 US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA.
RP Owens, EO (reprint author), US EPA, Natl Ctr Environm Assessment, 109 TW Alexander Dr,Mailcode B-243-01, Res Triangle Pk, NC 27711 USA.
EM owens.beth@epa.gov
NR 81
TC 22
Z9 22
U1 2
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD OCT
PY 2010
VL 43
IS 15
BP 1183
EP 1188
DI 10.1016/j.clinbiochem.2010.07.011
PG 6
WC Medical Laboratory Technology
SC Medical Laboratory Technology
GA 654XM
UT WOS:000282204400001
PM 20655892
ER
PT J
AU Zhao, AZ
Ohara-Imaizumi, M
Brissova, M
Benninger, RKP
Xu, YW
Hao, YH
Abramowitz, J
Boulay, G
Powers, AC
Piston, D
Jiang, MS
Nagamatsu, S
Birnbaumer, L
Gu, GQ
AF Zhao, Aizhen
Ohara-Imaizumi, Mica
Brissova, Marcella
Benninger, Richard K. P.
Xu, Yanwen
Hao, Yuhan
Abramowitz, Joel
Boulay, Guylain
Powers, Alvin C.
Piston, David
Jiang, Meisheng
Nagamatsu, Shinya
Birnbaumer, Lutz
Gu, Guoqiang
TI G alpha o Represses Insulin Secretion by Reducing Vesicular Docking in
Pancreatic beta-Cells
SO DIABETES
LA English
DT Article
ID ISLET-ACTIVATING PROTEIN; B-CELLS; SOMATOSTATIN INHIBITION; PRESYNAPTIC
INHIBITION; GRANULE EXOCYTOSIS; MEMBRANE-PROTEIN; ADP-RIBOSYLATION;
GAMMA-DIMERS; MOUSE; MECHANISMS
AB OBJECTIVE Pertussis toxin uncoupling-based studies have shown that Gal and G alpha o can inhibit insulin secretion in pancreatic beta-cells. Yet it is unclear whether G alpha i and G alpha o operate through identical mechanisms and how these G-protein-mediated signals inhibit insulin secretion in vivo. Our objective is to examine whether/how G alpha o regulates islet development and insulin secretion in beta-cells.
RESEARCH DESIGN AND METHODS Immunoassays were used to analyze the G alpha o expression in mouse pancreatic cells. G alpha o was specifically inactivated in pancreatic progenitor cells by pancreatic cell-specific gene deletion. Hormone expression and insulin secretion in response to different stimuli were assayed in vivo and in vitro. Electron microscope and total internal reflection fluorescence-based assays were used to evaluate how G alpha o regulates insulin vesicle docking and secretion in response to glucose stimulation.
RESULTS Islet cells differentiate properly in G alpha o(-/-) mutant mice. G alpha o inactivation significantly enhances insulin secretion both in vivo and in isolation. G alpha o nullizygous beta-cells contain an increased number of insulin granules docked on the cell plasma membrane, although the total number of vesicles per beta-cell remains unchanged.
CONCLUSIONS-G alpha o is not required for endocrine islet cell differentiation, but it regulates the number of insulin vesicles docked on the beta-cell membrane. Diabetes 59:2522-2529, 2010
C1 [Zhao, Aizhen; Xu, Yanwen; Hao, Yuhan; Gu, Guoqiang] Vanderbilt Univ, Med Ctr, Program Dev Biol, Nashville, TN 37203 USA.
[Zhao, Aizhen; Xu, Yanwen; Hao, Yuhan; Gu, Guoqiang] Vanderbilt Univ, Med Ctr, Dept Cell & Dev Biol, Nashville, TN USA.
[Ohara-Imaizumi, Mica; Nagamatsu, Shinya] Kyorin Univ, Sch Med Mitaka, Dept Biochem, Tokyo, Japan.
[Brissova, Marcella; Benninger, Richard K. P.; Powers, Alvin C.; Piston, David] Vanderbilt Univ, Med Ctr, Dept Mol Physiol & Biophys, Nashville, TN USA.
[Brissova, Marcella; Powers, Alvin C.] Vanderbilt Univ, Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Nashville, TN USA.
[Brissova, Marcella; Powers, Alvin C.] VA Tennessee Valley Healthcare Syst, Nashville, TN USA.
[Abramowitz, Joel; Birnbaumer, Lutz] Natl Inst Environm Hlth Sci, Transmembrane Signaling Grp, Neurobiol Lab, NIH,Dept Hlth & Human Serv, Res Triangle Pk, NC USA.
[Boulay, Guylain] Univ Sherbrooke, Sch Med, Dept Pharmacol, Sherbrooke, PQ J1H 5N4, Canada.
[Jiang, Meisheng] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA USA.
RP Gu, GQ (reprint author), Vanderbilt Univ, Med Ctr, Program Dev Biol, Nashville, TN 37203 USA.
EM guoqiang.gu@vanderbilt.edu
RI Abramowitz, Joel/A-2620-2015;
OI benninger, richard/0000-0002-5063-6096
FU National Institutes of Health [DK-069771, DK-53434, Z01-ES-101643,
DK-66636, DK-69603, DK-63439]; JDRF [2009-371]; VA Research Service;
Vanderbilt Mouse Metabolic Phenotyping Center [DK-59637]; Vanderbilt
Diabetes Research and Training Center [DK-20593]; KAKENHI [C-20570189,
21113523, B-20390260]; Sumitomo Foundation; Research Foundation for
Opto-Science and Technology
FX This research was supported by grants from the National Institutes of
Health (DK-069771 to M.J., DK-53434 to D.P.), JDRF (2009-371 to G.G.),
and by the Intramural Research Program of the National Institutes of
Health (Z01-ES-101643 to L.B.). A.C.P. was supported by grants from the
JDRF, the VA Research Service, the National Institutes of Health
(DK-66636, DK-69603, and DK-63439), the Vanderbilt Mouse Metabolic
Phenotyping Center (DK-59637), and the Vanderbilt Diabetes Research and
Training Center (DK-20593). S.N. was supported by the following
resource: KAKENHI (C-20570189, 21113523 to M.O.-I., B-20390260 to S.N.),
Sumitomo Foundation (to Astellas Foundation for Research on Metabolic
Disorders (M.O.-I.), and Research Foundation for Opto-Science and
Technology (M.O.-I.). TEM was performed in the Vanderbilt EM core
facility, with help from Denny Kerns, Matt Stephenson, and Mary Dawes.
The color print fee cost was covered by JDRF.
NR 48
TC 11
Z9 11
U1 0
U2 4
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
J9 DIABETES
JI Diabetes
PD OCT
PY 2010
VL 59
IS 10
BP 2522
EP 2529
DI 10.2337/db09-1719
PG 8
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 667PJ
UT WOS:000283205700025
PM 20622165
ER
EF