FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Hill, J Kayentao, K Achieng, F Diarra, S Dellicour, S Diawara, SI Hamel, MJ Ouma, P Desai, M Doumbo, OK ter Kuile, FO Webster, J AF Hill, Jenny Kayentao, Kassoum Achieng, Florence Diarra, Samba Dellicour, Stephanie Diawara, Sory I. Hamel, Mary J. Ouma, Peter Desai, Meghna Doumbo, Ogobara K. ter Kuile, Feiko O. Webster, Jayne TI Access and Use of Interventions to Prevent and Treat Malaria among Pregnant Women in Kenya and Mali: A Qualitative Study SO PLOS ONE LA English DT Article ID ANTENATAL CARE; BIRTH-WEIGHT; AFRICA; METAANALYSIS; BURDEN AB Background Coverage of malaria in pregnancy interventions in sub-Saharan Africa is suboptimal. We undertook a systematic examination of the operational, socio-economic and cultural constraints to pregnant women's access to intermittent preventive treatment (IPTp), long-lasting insecticide-treated nets (LLINs) and case management in Kenya and Mali to provide empirical evidence for strategies to improve coverage. Methods Focus group discussions (FGDs) were held as part of a programme of research to explore the delivery, access and use of interventions to control malaria in pregnancy. FGDs were held with four sub-groups: non-pregnant women of child bearing age (aged 15-49 years), pregnant women or mothers of children aged <1 year, adolescent women, and men. Content analysis was used to develop themes and sub-themes from the data. Results Women and men's perceptions of the benefits of antenatal care were generally positive; motivation among women consisted of maintaining a healthy pregnancy, disease prevention in mother and foetus, checking the position of the baby in preparation for delivery, and ensuring admission to a facility in case of complications. Barriers to accessing care related to the quality of the health provider-client interaction, perceived health provider skills and malpractice, drug availability, and cost of services. Pregnant women perceived themselves and their babies at particular risk from malaria, and valued diagnosis and treatment from a health professional, but cost of treatment at health facilities drove women to use herbal \remedies or drugs bought from shops. Women lacked information on the safety, efficacy and side effects of antimalarial use in pregnancy. Conclusion Women in these settings appreciated the benefits of antenatal care and yet health services in both countries are losing women to follow-up due to factors that can be improved with greater political will. Antenatal services need to be patient-centred, free-of-charge or highly affordable and accountable to the women they serve. C1 [Hill, Jenny; Dellicour, Stephanie; ter Kuile, Feiko O.] Univ Liverpool, Liverpool Sch Trop Med, Dept Clin Sci, Liverpool L3 5QA, Merseyside, England. [Kayentao, Kassoum; Diarra, Samba; Diawara, Sory I.; Doumbo, Ogobara K.] Univ Sci Tech & Technol, Malaria Res & Training Ctr, Bamako, Mali. [Achieng, Florence; Ouma, Peter] Ctr Global Hlth Res, Kenya Med Res Inst, Kisumu, Kenya. [Hamel, Mary J.; Desai, Meghna] Ctr Dis Control & Prevent, Atlanta, GA USA. [Webster, Jayne] Ctr Dis Control & Prevent, Atlanta, Kenya. [Webster, Jayne] London Sch Trop Med & Hyg, Dis Control Dept, London, England. RP Hill, J (reprint author), Univ Liverpool, Liverpool Sch Trop Med, Dept Clin Sci, Liverpool L3 5QA, Merseyside, England. EM j.hill@liv.ac.uk OI ter Kuile, Feiko/0000-0003-3663-5617 FU Malaria in Pregnancy (MiP) Consortium through Bill & Melinda Gates Foundation FX This work was supported by the Malaria in Pregnancy (MiP) Consortium, which is funded through a grant from the Bill & Melinda Gates Foundation to the Liverpool School of Tropical Medicine, UK. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 37 TC 4 Z9 4 U1 2 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 23 PY 2015 VL 10 IS 3 AR e0119848 DI 10.1371/journal.pone.0119848 PG 23 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CE6ZS UT WOS:000351987300084 PM 25798847 ER PT J AU Seth, P Glenshaw, M Sabatier, JHF Adams, R Du Preez, V DeLuca, N Bock, N AF Seth, Puja Glenshaw, Mary Sabatier, Jennifer H. F. Adams, Rene Du Preez, Verona DeLuca, Nickolas Bock, Naomi TI AUDIT, AUDIT-C, and AUDIT-3: Drinking Patterns and Screening for Harmful, Hazardous and Dependent Drinking in Katutura, Namibia SO PLOS ONE LA English DT Article ID DISORDERS IDENTIFICATION TEST; SUB-SAHARAN AFRICA; ALCOHOL-USE; SOUTH-AFRICA; ABBREVIATED VERSIONS; SENSATION SEEKING; CLINIC PATIENTS; HIV-INFECTION; PRIMARY-CARE; CAPE-TOWN AB Objectives To describe alcohol drinking patterns among participants in Katutura, Namibia, and to evaluate brief versions of the AUDIT against the full AUDIT to determine their effectiveness in detecting harmful drinking. Methods A cross-sectional survey was conducted in four constituencies and 639 participants, 18 years or older, completed a sociodemographic survey and the AUDIT. The effectiveness of the AUDIT-C (first three questions) and the AUDIT-3 (third question) was compared to the full AUDIT. Results Approximately 40% were identified as harmful, hazardous or likely dependent drinkers, with men having a higher likelihood than women (57.2% vs. 31.0%, p<.0001). Approximately 32% reported making and/or selling alcohol from home. The AUDIT-C performed best at a cutoff >= 3, better in men (sensitivity: 99.3%, specificity: 77.8%) than women (sensitivity: 91.7%, specificity: 77.4%). The AUDIT-3 performed poorly (maximum sensitivity: < 90%, maximum specificity: < 51%). According to AUROC, the AUDIT-C performed better than the AUDIT-3. Conclusions A large proportion of participants met criteria for alcohol misuse, indicating a need for screening and referral for further evaluation and intervention. The AUDIT-C was almost as effective as the full AUDIT and may be easier to implement in clinical settings as a routine screening tool in resource-limited settings because of its brevity. C1 [Seth, Puja; Glenshaw, Mary; Sabatier, Jennifer H. F.; Bock, Naomi] Ctr Dis Control & Prevent, Div Global HIV AIDS, Atlanta, GA 30333 USA. [Adams, Rene; Du Preez, Verona] Minist Hlth & Social Serv, Windhoek, Namibia. [DeLuca, Nickolas] Ctr Dis Control & Prevent, Windhoek, Namibia. RP Seth, P (reprint author), Ctr Dis Control & Prevent, Div Global HIV AIDS, Atlanta, GA 30333 USA. EM pseth@cdc.gov FU President's Emergency Plan for AIDS Relief (PEPFAR) through the Centers for Disease Control and Prevention [PS002722] FX This research has been supported by the President's Emergency Plan for AIDS Relief (PEPFAR) through the Centers for Disease Control and Prevention under the terms of cooperative agreement#: PS002722. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 36 TC 4 Z9 4 U1 2 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 23 PY 2015 VL 10 IS 3 AR e0120850 DI 10.1371/journal.pone.0120850 PG 16 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CE6ZS UT WOS:000351987300182 PM 25799590 ER PT J AU Peng, ZB Feng, LZ Carolyn, GM Wang, KL Zhu, GZ Zhang, YQ Hu, JM Huang, YW Pan, HQ Guo, NJ Xing, CY Chu, YH Cao, ZL Yu, DS Liu, LL Chen, ZL Zeng, F Xu, W Xiong, X Cheng, XW Guo, H Chen, W Li, L Jiang, H Zheng, JD Xu, Z Yu, HJ AF Peng, Zhibin Feng, Luzhao Carolyn, Greene M. Wang, Kaili Zhu, Guozhong Zhang, Yequn Hu, Jumei Huang, Yiwei Pan, Huiqiong Guo, Nongjian Xing, Chunyan Chu, Yanhui Cao, Zhaolong Yu, Deshan Liu, Linling Chen, Zeling Zeng, Fang Xu, Wen Xiong, Xin Cheng, Xiuwei Guo, Hua Chen, Wu Li, Ling Jiang, Hui Zheng, Jiandong Xu, Zhen Yu, Hongjie TI Characterizing the epidemiology, virology, and clinical features of influenza in China's first severe acute respiratory infection sentinel surveillance system, February 2011-October 2013 SO BMC INFECTIOUS DISEASES LA English DT Article DE Epidemiology; Virology; Clinical features; Influenza positive patients; China AB Background: After the 2009 influenza A(H1N1) pdm09 pandemic, China established its first severe acute respiratory infections (SARI) sentinel surveillance system. Methods: We analyzed data from SARI cases in 10 hospitals in 10 provinces in China from February 2011 to October 2013. Results: Among 5,644 SARI cases, 330 (6%) were influenza-positive. Among these, 62% were influenza A and 38% were influenza B. Compared with influenza-negative cases, influenza-positive SARI cases had a higher median age (20.0 years vs. 11.0, p = 0.003) and were more likely to have at least one underlying chronic medical condition (age adjusted percent: 28% vs. 25%, p < 0.001). The types/subtypes of dominant strains identified by SARI surveillance was almost always among dominant strains identified by the influenza like illness (ILI) surveillance system and influenza activity in both systems peaked at the same time. Conclusions: Data from China's first SARI sentinel surveillance system suggest that types/subtypes of circulating influenza strains and epidemic trends among SARI cases were similar to those among ILI cases. C1 [Peng, Zhibin; Feng, Luzhao; Jiang, Hui; Zheng, Jiandong; Xu, Zhen; Yu, Hongjie] Chinese Ctr Dis Control & Prevent, Key Lab Surveillance & Early Warning Infect Dis, Div Infect Dis, Beijing, Peoples R China. [Carolyn, Greene M.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Wang, Kaili] Heilongjiang Prov Ctr Dis Control & Prevent, Haerbin, Peoples R China. [Zhu, Guozhong] Heilongjiang Prov Hosp, Haerbin, Peoples R China. [Zhang, Yequn] HuzhouCtr Dis Control & Prevent, Huzhou, Peoples R China. [Hu, Jumei] Huzhou First Peoples Hosp, Huzhou, Peoples R China. [Huang, Yiwei] Hunan Prov Ctr Dis Control & Prevent, Changsha, Hunan, Peoples R China. [Pan, Huiqiong] First Hosp Changsha, Changsha, Hunan, Peoples R China. [Guo, Nongjian; Xing, Chunyan] Jinan Ctr Hosp, Jinan, Peoples R China. [Chu, Yanhui] XichengCtr Dis Control & Prevent, Beijing, Peoples R China. [Cao, Zhaolong] Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China. [Yu, Deshan] Gansu Prov Ctr Dis Control & Prevent, Lanzhou, Peoples R China. [Liu, Linling] Lanzhou Univ, Hosp 1, Lanzhou 730000, Peoples R China. [Chen, Zeling] Zhuhai Ctr Dis Control & Prevent, Zhuhai, Peoples R China. [Zeng, Fang] Zhuhai Peoples Hosp, Zhuhai, Peoples R China. [Xu, Wen] Yunnan Prov Ctr Dis Control & Prevent, Kunming, Peoples R China. [Xiong, Xin] Kunming Med Univ, Affiliated Hosp 1, Kunming, Peoples R China. [Cheng, Xiuwei] Sichuan Prov Ctr Dis Control & Prevent, Chengdu, Peoples R China. [Guo, Hua] Third Peoples Hosp Chengdu, Chengdu, Peoples R China. [Chen, Wu] Fujian Prov Ctr Dis Control & Prevent, Fuzhou, Peoples R China. [Li, Ling] Fujian Med Univ, Affiliated Hosp 1, Fuzhou, Peoples R China. RP Yu, HJ (reprint author), Chinese Ctr Dis Control & Prevent, Key Lab Surveillance & Early Warning Infect Dis, Div Infect Dis, Beijing, Peoples R China. EM yuhj@chinacdc.cn FU China-U.S. Collaborative Program on Emerging and Re-emerging Infectious Diseases; China-WHO Influenza Surveillance Project FX This study was supported by grants from the China-U.S. Collaborative Program on Emerging and Re-emerging Infectious Diseases and China-WHO Influenza Surveillance Project. NR 26 TC 6 Z9 7 U1 2 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD MAR 22 PY 2015 VL 15 AR 143 DI 10.1186/s12879-015-0884-1 PG 10 WC Infectious Diseases SC Infectious Diseases GA CE1KA UT WOS:000351569300001 PM 25885096 ER PT J AU Wain, J Hendriksen, RS Mikoleit, ML Keddy, KH Ochiai, RL AF Wain, John Hendriksen, Rene S. Mikoleit, Matthew L. Keddy, Karen H. Ochiai, R. Leon TI Typhoid fever SO LANCET LA English DT Article ID ENTERICA SEROVAR TYPHI; RESISTANT SALMONELLA-TYPHI; CONTROLLED FIELD TRIAL; MULTIDRUG-RESISTANT; RISK-FACTORS; POLYSACCHARIDE VACCINE; BETA-LACTAMASE; SOUTH-AFRICA; PARATYPHI-A; FLUOROQUINOLONE RESISTANCE AB Control of typhoid fever relies on clinical information, diagnosis, and an understanding for the epidemiology of the disease. Despite the breadth of work done so far, much is not known about the biology of this human-adapted bacterial pathogen and the complexity of the disease in endemic areas, especially those in Africa. The main barriers to control are vaccines that are not immunogenic in very young children and the development of multidrug resistance, which threatens efficacy of antimicrobial chemotherapy. Clinicians, microbiologists, and epidemiologists worldwide need to be familiar with shifting trends in enteric fever. This knowledge is crucial, both to control the disease and to manage cases. Additionally, salmonella serovars that cause human infection can change over time and location. In areas of Asia, multidrug-resistant Salmonella enterica serovar Typhi (S Typhi) has been the main cause of enteric fever, but now S Typhi is being displaced by infections with drug-resistant S enterica serovar Paratyphi A. New conjugate vaccines are imminent and new treatments have been promised, but the engagement of local medical and public health institutions in endemic areas is needed to allow surveillance and to implement control measures. C1 [Wain, John] Univ E Anglia, Norwich Med Sch, Norwich NR4 7TJ, Norfolk, England. [Hendriksen, Rene S.] Tech Univ Denmark, Natl Food Inst, WHO Collaborating Ctr Antimicrobial Resistance Fo, Kongens Lyngby, Denmark. [Hendriksen, Rene S.] European Union Reference Lab Antimicrobial Resist, Kongens Lyngby, Denmark. [Mikoleit, Matthew L.] Ctr Dis Control & Prevent, Enter Dis Lab Branch, Natl Enter Reference Lab Team, Atlanta, GA USA. [Keddy, Karen H.] Natl Inst Communicable Dis, Div Natl Hlth Lab Serv NHLS, Ctr Enter Dis, Johannesburg, South Africa. [Keddy, Karen H.] Univ Witwatersrand, Fac Hlth Sci, Johannesburg, South Africa. [Ochiai, R. Leon] Independent Consultant Vaccines, Tokyo, Japan. RP Wain, J (reprint author), Innovat Ctr, Norwich Res Pk, Norwich NR4 7GJ, Norfolk, England. EM j.wain@uea.ac.uk RI Wain, John/B-3446-2013 OI Ochiai, Leon/0000-0002-5079-6786; Wain, John/0000-0002-1257-1148 FU Medical Research Council [G0600805] NR 136 TC 39 Z9 40 U1 5 U2 28 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0140-6736 EI 1474-547X J9 LANCET JI Lancet PD MAR 21 PY 2015 VL 385 IS 9973 BP 1136 EP 1145 DI 10.1016/S0140-6736(13)62708-7 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA CD7KX UT WOS:000351270400032 PM 25458731 ER PT J AU Tryon, C Hopkins, P Khan, A Walton, W AF Tryon, C. Hopkins, P. Khan, A. Walton, W. TI Teachback methodology: building global training capacity with a unique training-of-trainers course SO PUBLIC HEALTH ACTION LA English DT Article DE training skills; adult learning; capacity building; feedback AB To meet the global demand for training assistance in tuberculosis (TB) and human immunodeficiency virus (HIV) infection, a systematic model was created to conduct training-of-trainers courses. The Teachback Methodology curriculum was created using adult learning principles and implemented by collaborating with partners to create training-of-trainers courses. A total of 42 courses were held in 18 countries, resulting in 901 participants being able to enhance their training skills. During training-of-trainers courses, the participants practice teaching a course. Trainers observe the participants' performance and provide feedback on training skills and accuracy of course content. The methodology can be integrated with TB and HIV courses to enhance training capacity and help build a competent workforce. C1 [Tryon, C.; Hopkins, P.; Khan, A.; Walton, W.] Ctr Dis Control & Prevent, Div TB Eliminat, US Dept HHS, 1246 Biltmore Dr NE, Atlanta, GA 30329 USA. RP Tryon, C (reprint author), Ctr Dis Control & Prevent, Div TB Eliminat, US Dept HHS, 1246 Biltmore Dr NE, Atlanta, GA 30329 USA. EM ctryon100@gmail.com NR 4 TC 0 Z9 0 U1 0 U2 0 PU INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) PI PARIS PA 68 BOULEVARD SAINT-MICHEL,, 75006 PARIS, FRANCE SN 2220-8372 J9 PUBLIC HEALTH ACTION JI PUBLIC HEALTH ACTION PD MAR 21 PY 2015 VL 5 IS 1 BP 79 EP 82 DI 10.5588/pha.14.0103 PG 4 WC Respiratory System SC Respiratory System GA DL2ET UT WOS:000375446900013 PM 26400606 ER PT J AU Scott, C Kirking, HL Jeffries, C Price, SF Pratt, R AF Scott, Colleen Kirking, Hannah L. Jeffries, Carla Price, Sandy F. Pratt, Robert TI Tuberculosis Trends - United States, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID FOREIGN-BORN PERSONS C1 [Scott, Colleen; Kirking, Hannah L.] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Scott, Colleen; Kirking, Hannah L.; Jeffries, Carla; Price, Sandy F.; Pratt, Robert] CDC, Div TB Eliminat, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. RP Scott, C (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM ibk9@cdc.gov NR 8 TC 30 Z9 30 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAR 20 PY 2015 VL 64 IS 10 BP 265 EP 269 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CE2HG UT WOS:000351635500002 PM 25789741 ER PT J AU Spiller, MW Broz, D Wejnert, C Nerlander, L Paz-Bailey, G AF Spiller, Michael W. Broz, Dita Wejnert, Cyprian Nerlander, Lina Paz-Bailey, Gabriela CA Natl HIV Behav Surveillance Syst TI HIV Infection and HIV-Associated Behaviors Among Persons Who Inject Drugs-20 Cities, United States, 2012 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Spiller, Michael W.; Broz, Dita; Wejnert, Cyprian; Nerlander, Lina; Paz-Bailey, Gabriela; Natl HIV Behav Surveillance Syst] CDC, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. RP Spiller, MW (reprint author), CDC, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. EM mspiller@cdc.gov NR 10 TC 16 Z9 16 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAR 20 PY 2015 VL 64 IS 10 BP 270 EP 275 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CE2HG UT WOS:000351635500003 PM 25789742 ER PT J AU Lee-Kwan, SH Kumar, G Ayscue, P Santos, M McGuire, LC Blanck, HM Nua, MT AF Lee-Kwan, Seung Hee Kumar, Gayathri Ayscue, Patrick Santos, Marjorie McGuire, Lisa C. Blanck, Heidi M. Nua, Motusa Tuileama TI Healthful Food Availability in Stores and Restaurants - American Samoa, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID NUTRITION ENVIRONMENT MEASURES C1 [Lee-Kwan, Seung Hee; Kumar, Gayathri; Ayscue, Patrick] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Santos, Marjorie] CDC, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [McGuire, Lisa C.; Blanck, Heidi M.] CDC, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. RP Lee-Kwan, SH (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM SLeeKwan@cdc.gov NR 10 TC 2 Z9 2 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAR 20 PY 2015 VL 64 IS 10 BP 276 EP 278 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CE2HG UT WOS:000351635500004 PM 25789743 ER PT J AU DeSilva, M Sharma, A Staples, E Arndt, B Shieh, WJ Shames, J Cieslak, P AF DeSilva, Malini Sharma, Arun Staples, Erin Arndt, Byron Shieh, Wun-Ju Shames, Jim Cieslak, Paul TI Fatal Yellow Fever Vaccine-Associated Viscerotropic Disease - Oregon, September 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID THYMOMA C1 [DeSilva, Malini] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Sharma, Arun] Asante Hlth Syst, Neurocrit Care Crit Care Med, Medford, OR USA. [Staples, Erin] CDC, Arboviral Dis Branch, Div Vector Borne Dis, Atlanta, GA 30333 USA. [Arndt, Byron] Vista Pathol, Medford, OR USA. [Shieh, Wun-Ju] CDC, Infect Dis Pathol Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA 30333 USA. [Shames, Jim] Jackson Cty Hlth & Human Serv, Medford, OR USA. [Cieslak, Paul] Oregon Hlth Author, Ctr Publ Hlth Practice, Acute & Communicable Dis, Portland, OR USA. RP DeSilva, M (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM xdh8@cdc.gov NR 7 TC 7 Z9 7 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAR 20 PY 2015 VL 64 IS 10 BP 279 EP 281 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CE2HG UT WOS:000351635500005 PM 25789744 ER PT J AU Jackson, BR Salter, M Tarr, C Conrad, A Harvey, E Steinbock, L Saupe, A Sorenson, A Katz, L Stroika, S Jackson, KA Carleton, H Kucerova, Z Melka, D Strain, E Parish, M Mody, RK AF Jackson, Brendan R. Salter, Monique Tarr, Cheryl Conrad, Amanda Harvey, Emily Steinbock, Lisa Saupe, Amy Sorenson, Alida Katz, Lee Stroika, Steven Jackson, Kelly A. Carleton, Heather Kucerova, Zuzana Melka, David Strain, Errol Parish, Mickey Mody, Rajal K. TI Listeriosis Associated with Stone Fruit - United States, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Jackson, Brendan R.; Tarr, Cheryl; Conrad, Amanda; Katz, Lee; Stroika, Steven; Jackson, Kelly A.; Carleton, Heather; Kucerova, Zuzana; Mody, Rajal K.] CDC, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Salter, Monique; Melka, David; Strain, Errol; Parish, Mickey] US FDA, Rockville, MD 20857 USA. [Conrad, Amanda] Atlanta Res & Educ Fdn, Atlanta, GA USA. [Harvey, Emily] Massachusetts Dept Publ Hlth, Boston, MA 02111 USA. [Steinbock, Lisa] City Northampton Hlth Dept, Northampton, MA USA. [Saupe, Amy] Minnesota Dept Hlth, Minneapolis, MN 55414 USA. [Sorenson, Alida] Minnesota Dept Agr, St Paul, MN USA. RP Jackson, BR (reprint author), CDC, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. EM brjackson1@cdc.gov NR 1 TC 15 Z9 15 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAR 20 PY 2015 VL 64 IS 10 BP 282 EP 283 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CE2HG UT WOS:000351635500006 PM 25789745 ER PT J AU Peeling, RW Sollis, KA Glover, S Crowe, SM Landay, AL Cheng, B Barnett, D Denny, TN Spira, TJ Stevens, WS Crowley, S Essajee, S Vitoria, M Ford, N AF Peeling, Rosanna W. Sollis, Kimberly A. Glover, Sarah Crowe, Suzanne M. Landay, Alan L. Cheng, Ben Barnett, David Denny, Thomas N. Spira, Thomas J. Stevens, Wendy S. Crowley, Siobhan Essajee, Shaffiq Vitoria, Marco Ford, Nathan TI CD4 Enumeration Technologies: A Systematic Review of Test Performance for Determining Eligibility for Antiretroviral Therapy SO PLOS ONE LA English DT Article ID HIV-INFECTED INDIVIDUALS; RESOURCE-LIMITED SETTINGS; T-CELL ENUMERATION; LOW-COST METHOD; FLOW-CYTOMETRY; ABSOLUTE CD4(+); LYMPHOCYTE COUNTS; SINGLE-PLATFORM; FACSCOUNT SYSTEM; HIV-1-INFECTED PATIENTS AB Background Measurement of CD4(+) T-lymphocytes (CD4) is a crucial parameter in the management of HIV patients, particularly in determining eligibility to initiate antiretroviral treatment (ART). A number of technologies exist for CD4 enumeration, with considerable variation in cost, complexity, and operational requirements. We conducted a systematic review of the performance of technologies for CD4 enumeration. Methods and Findings Studies were identified by searching electronic databases MEDLINE and EMBASE using a pre-defined search strategy. Data on test accuracy and precision included bias and limits of agreement with a reference standard, and misclassification probabilities around CD4 thresholds of 200 and 350 cells/beta l over a clinically relevant range. The secondary outcome measure was test imprecision, expressed as % coefficient of variation. Thirty-two studies evaluating 15 CD4 technologies were included, of which less than half presented data on bias and misclassification compared to the same reference technology. At CD4 counts <350 cells/mu l, bias ranged from -35.2 to +13.1 cells/mu l while at counts >350 cells/mu l, bias ranged from -70.7 to +47 cells/mu l, compared to the BD FACSCount as a reference technology. Misclassification around the threshold of 350 cells/mu l ranged from 1-29% for upward classification, resulting in under-treatment, and 7-68% for downward classification resulting in overtreatment. Less than half of these studies reported within laboratory precision or reproducibility of the CD4 values obtained. Conclusions A wide range of bias and percent misclassification around treatment thresholds were reported on the CD4 enumeration technologies included in this review, with few studies reporting assay precision. The lack of standardised methodology on test evaluation, including the use of different reference standards, is a barrier to assessing relative assay performance and could hinder the introduction of new point-of-care assays in countries where they are most needed. C1 [Peeling, Rosanna W.; Sollis, Kimberly A.; Glover, Sarah] London Sch Hyg & Trop Med, London WC1E 7HT, England. [Crowe, Suzanne M.] Burnet Inst, Ctr Biomed Res, Melbourne, Vic 3004, Australia. [Landay, Alan L.] Rush Univ, Med Ctr, Dept Immunol Microbiol, Chicago, IL 60612 USA. [Cheng, Ben] Pangaea Global AIDS Fdn, Oakland, CA USA. [Barnett, David] UK NEQAS Leucocyte Immunophenotyping, Sheffield S10 2QD, S Yorkshire, England. [Denny, Thomas N.] Duke Human Vaccine Inst, Durham, NC 27710 USA. [Denny, Thomas N.] Immunol & Virol Qual Assessment Ctr, Ctr HIV AIDS, Durham, NC 27710 USA. [Spira, Thomas J.] Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Div AIDS STD & TB Lab Res, Atlanta, GA 30333 USA. [Stevens, Wendy S.] Univ Witwatersrand, ZA-2193 Parktown, South Africa. [Crowley, Siobhan] ELMA Philanthropies, Director Hlth Programs, New York, NY USA. [Essajee, Shaffiq] Clinton Hlth Access Initiat, Boston, MA 02127 USA. [Vitoria, Marco; Ford, Nathan] WHO, CH-1211 Geneva, Switzerland. RP Peeling, RW (reprint author), London Sch Hyg & Trop Med, London WC1E 7HT, England. EM rosanna.peeling@lshtm.ac.uk FU World Health Organization FX The funding for this study was provided by the World Health Organization to the London School of Hygiene and Tropical Medicine. The decision to write this article was not influenced by any diagnostic or commercial company. The mention of specific companies or of certain manufacturers' products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 71 TC 7 Z9 7 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 19 PY 2015 VL 10 IS 3 AR e0115019 DI 10.1371/journal.pone.0115019 PG 26 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CD9NQ UT WOS:000351425400006 PM 25790185 ER PT J AU Cohen, C Moyes, J Tempia, S Groome, M Walaza, S Pretorius, M Dawood, H Chhagan, M Haffejee, S Variava, E Kahn, K von Gottberg, A Wolter, N Cohen, AL Malope-Kgokong, B Venter, M Madhi, SA AF Cohen, Cheryl Moyes, Jocelyn Tempia, Stefano Groome, Michelle Walaza, Sibongile Pretorius, Marthi Dawood, Halima Chhagan, Meera Haffejee, Summaya Variava, Ebrahim Kahn, Kathleen von Gottberg, Anne Wolter, Nicole Cohen, Adam L. Malope-Kgokong, Babatyi Venter, Marietjie Madhi, Shabir A. TI Mortality amongst Patients with Influenza-Associated Severe Acute Respiratory Illness, South Africa, 2009-2013 SO PLOS ONE LA English DT Article ID A H1N1 VIRUS; PANDEMIC INFLUENZA; SYNCYTIAL VIRUS; UNITED-STATES; HIV; INFECTION; PREVALENCE; CHILDREN; ADULTS; HOSPITALIZATIONS AB Introduction Data on the burden and risk groups for influenza-associated mortality from Africa are limited. We aimed to estimate the incidence and risk-factors for in-hospital influenza-associated severe acute respiratory illness (SARI) deaths. Methods Hospitalised patients with SARI were enrolled prospectively in four provinces of South Africa from 2009-2013. Using polymerase chain reaction, respiratory samples were tested for ten respiratory viruses and blood for pneumococcal DNA. The incidence of influenza-associated SARI deaths was estimated at one urban hospital with a defined catchment population. Results We enrolled 1376 patients with influenza-associated SARI and 3% (41 of 1358 with available outcome data) died. In patients with available HIV-status, the case-fatality proportion (CFP) was higher in HIV-infected (5%, 22/419) than HIV-uninfected individuals (2%, 13/620; p = 0.006). CFPs varied by age group, and generally increased with increasing age amongst individuals >5 years (p<0.001). On multivariable analysis, factors associated with death were age-group 45-64 years (odds ratio (OR) 4.0, 95% confidence interval (CI) 1.01-16.3) and >= 65 years (OR 6.5, 95% CI 1.2-34.3) compared to 1-4 year age-group who had the lowest CFP, HIV-infection (OR 2.9, 95% CI 1.1-7.8), underlying medical conditions other than HIV (OR 2.9, 95% CI 1.2-7.3) and pneumococcal co-infection (OR 4.1, 95% CI 1.5-11.2). The estimated incidence of influenza-associated SARI deaths per 100,000 population was highest in children <1 year (20.1, 95% CI 12.1-31.3) and adults aged 45-64 years (10.4, 95% CI 8.4-12.9). Adjusting for age, the rate of death was 20-fold (95% CI 15.0-27.8) higher in HIV-infected individuals than HIV-uninfected individuals. Conclusion Influenza causes substantial mortality in urban South Africa, particularly in infants aged <1 year and HIV-infected individuals. More widespread access to antiretroviral treatment and influenza vaccination may reduce this burden. C1 [Cohen, Cheryl; Moyes, Jocelyn; Walaza, Sibongile; von Gottberg, Anne; Wolter, Nicole; Malope-Kgokong, Babatyi; Madhi, Shabir A.] Natl Inst Communicable Dis, Natl Hlth Lab Serv, Ctr Resp Dis & Meningitis, Johannesburg, South Africa. [Cohen, Cheryl; Moyes, Jocelyn] Univ Witwatersrand, Fac Hlth Sci, Sch Publ Hlth, Johannesburg, South Africa. [Tempia, Stefano; Cohen, Adam L.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. [Tempia, Stefano; Cohen, Adam L.] Ctr Dis Control & Prevent South Africa, Influenza Programme, Pretoria, South Africa. [Groome, Michelle; von Gottberg, Anne; Wolter, Nicole; Madhi, Shabir A.] Univ Witwatersrand, Fac Hlth Sci, Med Res Council, Resp & Meningeal Pathogens Res Unit, Johannesburg, South Africa. [Groome, Michelle; Madhi, Shabir A.] Univ Witwatersrand, Dept Sci & Technol, Natl Res Fdn Vaccine Preventable Dis, Johannesburg, South Africa. [von Gottberg, Anne; Wolter, Nicole] Univ Witwatersrand, Sch Pathol, Fac Hlth Sci, Johannesburg, South Africa. [Pretorius, Marthi; Venter, Marietjie] Univ Pretoria, Dept Med Virol, Zoonosis Res Unit, ZA-0002 Pretoria, South Africa. [Variava, Ebrahim] Klerksdorp Tshepong Hosp, Dept Med, Uraniaville, South Africa. [Variava, Ebrahim] Univ Witwatersrand, Dept Med, Fac Hlth Sci, ZA-2001 Johannesburg, South Africa. [Kahn, Kathleen] Univ Witwatersrand, Fac Hlth Sci, Sch Publ Hlth, MRC Wits Rural Publ Hlth & Hlth Transit Res Unit, Johannesburg, South Africa. [Kahn, Kathleen] Umea Univ, Ctr Global Hlth Res, Umea, Sweden. [Kahn, Kathleen] INDEPTH Network, Accra, Ghana. [Chhagan, Meera] Univ KwaZulu Natal, Dept Paediat, Durban, South Africa. [Dawood, Halima] Pietermaritzburg Metropolitan Hosp, Dept Med, Pietermaritzburg, South Africa. [Dawood, Halima] Univ KwaZulu Natal, Dept Med, Durban, South Africa. [Haffejee, Summaya] Univ KwaZulu Natal, Sch Pathol, Durban, South Africa. [Venter, Marietjie] US Ctr Dis Control & Prevent South Africa, Global Dis Detect, Pretoria, South Africa. RP Cohen, C (reprint author), Natl Inst Communicable Dis, Natl Hlth Lab Serv, Ctr Resp Dis & Meningitis, Johannesburg, South Africa. EM cherylc@nicd.ac.za RI Venter, Marietjie/P-9604-2016 OI Venter, Marietjie/0000-0003-2696-824X FU NICD/NHLS; United States Centers for Disease Control and Prevention (CDC), Atlanta, Georgia [U51/IP000155-04] FX This study received funding from the NICD/NHLS and was supported in part by funds from the United States Centers for Disease Control and Prevention (CDC), Atlanta, Georgia Preparedness and Response to Avian and Pandemic Influenza in South Africa (Cooperative Agreement Number: U51/IP000155-04). The contents are solely the responsibility of the authors and do not necessarily represent the official views of the CDC. The funders had no role in study design, implementation, manuscript writing or the decision to submit for publication. The corresponding author had full access to all the data in the study and takes final responsibility for the decision to submit for publication. NR 39 TC 12 Z9 12 U1 0 U2 9 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 18 PY 2015 VL 10 IS 3 AR e0118884 DI 10.1371/journal.pone.0118884 PG 15 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CE9BN UT WOS:000352138500054 PM 25786103 ER PT J AU Gatton, ML Rees-Channer, RR Glenn, J Barnwell, JW Cheng, Q Chiodini, PL Incardona, S Gonzalez, IJ Cunningham, J AF Gatton, Michelle L. Rees-Channer, Roxanne R. Glenn, Jeffrey Barnwell, John W. Cheng, Qin Chiodini, Peter L. Incardona, Sandra Gonzalez, Iveth J. Cunningham, Jane TI Pan-Plasmodium band sensitivity for Plasmodium falciparum detection in combination malaria rapid diagnostic tests and implications for clinical management SO MALARIA JOURNAL LA English DT Article DE Malaria; Rapid diagnostic test; HRP2; pLDH; Persistent antigenemia ID PLDH; CHILDREN; UGANDA AB Background: Malaria rapid diagnostic tests (RDTs) are appropriate for case management, but persistent antigenaemia is a concern for HRP2-detecting RDTs in endemic areas. It has been suggested that pan-pLDH test bands on combination RDTs could be used to distinguish persistent antigenaemia from active Plasmodium falciparum infection, however this assumes all active infections produce positive results on both bands of RDTs, an assertion that has not been demonstrated. Methods: In this study, data generated during the WHO-FIND product testing programme for malaria RDTs was reviewed to investigate the reactivity of individual test bands against P. falciparum in 18 combination RDTs. Each product was tested against multiple wild-type P. falciparum only samples. Antigen levels were measured by quantitative ELISA for HRP2, pLDH and aldolase. Results: When tested against P. falciparum samples at 200 parasites/mu L, 92% of RDTs were positive; 57% of these on both the P. falciparum and pan bands, while 43% were positive on the P. falciparum band only. There was a relationship between antigen concentration and band positivity; >= 4 ng/mL of HRP2 produced positive results in more than 95% of P. falciparum bands, while >= 45 ng/mL of pLDH was required for at least 90% of pan bands to be positive. Conclusions: In active P. falciparum infections it is common for combination RDTs to return a positive HRP2 band combined with a negative pan-pLDH band, and when both bands are positive, often the pan band is faint. Thus active infections could be missed if the presence of a HRP2 band in the absence of a pan band is interpreted as being caused solely by persistent antigenaemia. C1 [Gatton, Michelle L.] Queensland Univ Technol, Sch Publ Hlth & Social Work, Brisbane, Qld 4001, Australia. [Rees-Channer, Roxanne R.; Chiodini, Peter L.] Univ Coll London Hosp, Hosp Trop Dis, Natl Inst Hlth Res, Biomed Res Ctr, London, England. [Glenn, Jeffrey; Barnwell, John W.] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA USA. [Cheng, Qin] Australian Army Malaria Inst, Drug Resistance & Diagnost, Brisbane, Qld, Australia. [Chiodini, Peter L.] London Sch Hyg & Trop Med, London WC1, England. [Incardona, Sandra; Gonzalez, Iveth J.] Fdn Innovat New Diagnost, Geneva, Switzerland. [Cunningham, Jane] WHO, Global Malaria Programme, CH-1211 Geneva, Switzerland. RP Gatton, ML (reprint author), Queensland Univ Technol, Sch Publ Hlth & Social Work, GPO Box 2434, Brisbane, Qld 4001, Australia. EM m.gatton@qut.edu.au OI Incardona, Sandra/0000-0003-4994-1736 FU World Health Organization [001] NR 17 TC 4 Z9 4 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD MAR 18 PY 2015 VL 14 AR 115 DI 10.1186/s12936-015-0629-z PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CD9PW UT WOS:000351431300001 PM 25889624 ER PT J AU Meyer, SA Kambou, JL Cohn, A Goodson, JL Flannery, B Medah, I Messonnier, N Novak, R Diomande, F Djingarey, MH Clark, TA Yameogo, I Fall, A Wannemuehler, K AF Meyer, Sarah A. Kambou, Jean Ludovic Cohn, Amanda Goodson, James L. Flannery, Brendan Medah, Isaie Messonnier, Nancy Novak, Ryan Diomande, Fabien Djingarey, Mamoudou H. Clark, Thomas A. Yameogo, Issaka Fall, Amadou Wannemuehler, Kathleen TI Serogroup A meningococcal conjugate (PsA-TT) vaccine coverage and measles vaccine coverage in Burkina Faso-Implications for introduction of PsA-TT into the Expanded Programme on Immunization SO VACCINE LA English DT Article DE Serogroup A meningococcal meningitis; Conjugate meningococcal vaccine; PsA-TT; Measles; Measles vaccine; Burkina Faso ID MENINGITIS; CARRIAGE; AMERICA AB Background: A new serogroup A meningococcal conjugate vaccine (PsA-TT, MenAfriVac (TM)) has been developed to combat devastating serogroup A Neisseria meningitis (MenA) epidemics in Africa. A mass immunization campaign targeting 1-29 year olds was conducted in Burkina Faso in December 2010. Protection of subsequent infant cohorts will be necessary through either introduction of PsA-TT into the routine Expanded Programme on Immunization (EPI) or periodic repeat mass vaccination campaigns. Objectives: To inform future immunization policy for PsA-IT vaccination of infants through a comparison of PsA-TT campaign vaccination coverage and routine measles-containing vaccine (MCV) coverage in Burkina Faso. Methods: A national survey was conducted in Burkina Faso during December 17-27, 2011 using stratified cluster sampling to assess PsA-TT vaccine coverage achieved by the 2010 nationwide immunization campaign among 2-30 year olds and routine MCV coverage among 12-23 month olds. Coverage estimates and 95% Confidence Intervals (CI) were calculated, reasons for non-vaccination and methods of campaign communication were described, and a multivariable analysis for factors associated with vaccination was conducted. Results: National overall PsA-TT campaign coverage was 95.9% (95% CI: 95.0-96.7) with coverage greater than 90% all 13 regions of Burkina Faso. National overall routine MCV coverage was 92.5% (95% CI: 90.5-94.1), but ranged from 75.3% to 95.3% by region. The primary predictor for PsA-TT vaccination among all age groups was a head of household informed of the campaign. PsA-TT vaccination was more likely in residents of rural settings, whereas MCV vaccination was more likely in residents of urban settings. Conclusion: Overall national vaccination rates in Burkina Faso were similar for PsA-TT and MCV vaccine. The regions with MCV coverage below targets may be at risk for sub-optimal vaccination coverage if PsA-TT is introduced in EPI. These results highlight the need for assessments of routine vaccination coverage to guide PsA-TT immunization policy in meningitis belt countries. Published by Elsevier Ltd. C1 [Meyer, Sarah A.; Cohn, Amanda; Messonnier, Nancy; Novak, Ryan; Diomande, Fabien; Clark, Thomas A.] Ctr Dis Control & Prevent, Meningitis & Vaccine Preventable Dis Branch, Atlanta, GA 30333 USA. [Meyer, Sarah A.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Kambou, Jean Ludovic] Burkina Faso Minist Hlth, Direct Prevent Vaccinat, Ouagadougou, Burkina Faso. [Goodson, James L.; Flannery, Brendan; Wannemuehler, Kathleen] Ctr Dis Control & Prevent, Global Immunizat Div, Atlanta, GA 30333 USA. [Medah, Isaie; Yameogo, Issaka] Burkina Faso Minist Hlth, Direct Lutte Malad, Ouagadougou, Burkina Faso. [Djingarey, Mamoudou H.; Fall, Amadou] World Hlth Org Intercountry Support Team West Afr, Ouagadougou, Burkina Faso. RP Meyer, SA (reprint author), US Ctr Dis Control & Prevent, Meningitis & Vaccine Preventable Dis Branch, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,MS C25, Atlanta, GA 30333 USA. EM smeyer@cdc.gov; kambouludo@hotmail.com; anc0@cdc.gov; fez9@cdc.gov; bif4@cdc.gov; isaiemedah@yahoo.fr; nar5@cdc.gov; bnk4@cdc.gov; fed2@cdc.gov; djingareyh@who.int; tnc4@cdc.gov; yameogoissaka@yahoo.fr; falla@who.int; kpw9@cdc.gov FU World Health Organization [001] NR 22 TC 4 Z9 4 U1 1 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD MAR 17 PY 2015 VL 33 IS 12 BP 1492 EP 1498 DI 10.1016/j.vaccine.2015.01.043 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA CF0QM UT WOS:000352249300012 PM 25636915 ER PT J AU Verner, MA Gaspar, FW Chevrier, J Gunier, RB Sjodin, A Bradman, A Eskenazi, B AF Verner, Marc-Andre Gaspar, Fraser W. Chevrier, Jonathan Gunier, Robert B. Sjoedin, Andreas Bradman, Asa Eskenazi, Brenda TI Increasing Sample Size in Prospective Birth Cohorts: Back-Extrapolating Prenatal Levels of Persistent Organic Pollutants in Newly Enrolled Children SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID POLYBROMINATED DIPHENYL ETHERS; IN-UTERO; POLYCHLORINATED-BIPHENYLS; HUMAN-SERUM; EXPOSURE; DDT; NEURODEVELOPMENT; ASSOCIATION; WEIGHT; BLOOD AB Study sample size in prospective birth cohorts of prenatal exposure to persistent organic pollutants (POPs) is limited by costs and logistics of follow-up. Increasing sample size at the time of health assessment would be beneficial If predictive tools could reliably back-extrapolate prenatal levels in newly enrolled children.. We evaluated the performance of three approaches to back-extrapolate prenatal levels of p,p'dichlorodiphenyltrichloroethane (DDT), p,p'-dichlorodiphenyldichloroethylene (DDE) and four polybrominated diphenyl ether (PBDE) congeners from maternal and/or child levels 9 years after delivery: a pharmacokinetic model and predictive models using deletion/substitution/addition or Super Learner algorithms. Model performance was assessed uSing the root mean squared error (RMSE), R-2, and slope and intercept of the back-extrapolated versus measured levels. Super Learner outperformed the Other approaches with RMSEs Of 0,10 to 0.31, R(2)s of 0.58 to 0.97, slopes of 0.42 to 0.93 and intercepts of 0.08 to 0.60. Typically, models performed better for p,p'-DDT/E than PBDE congeners. The pharmacokinetic model performed well when back-extrapolating prenatal levels from maternal levels for compounds with longer half-lives like p,p'-DDE and BDE-153. Results demonstrate the ability to reliably back-extrapolate prenatal POP levels from levels 9 years after delivery, with Super Learner performing best based on our fit criteria. C1 [Verner, Marc-Andre] Univ Montreal, Sch Publ Hlth, Dept Occupat & Environm Hlth, Montreal, PQ H3T 1J4, Canada. [Verner, Marc-Andre] Univ Montreal, Univ Montreal Publ Hlth Res Inst IRSPUM, Montreal, PQ H3T 1J4, Canada. [Gaspar, Fraser W.; Chevrier, Jonathan; Gunier, Robert B.; Bradman, Asa; Eskenazi, Brenda] Univ Calif Berkeley, Sch Publ Hlth, CERCH, Berkeley, CA 94720 USA. [Chevrier, Jonathan] McGill Univ, Fac Med, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ H3A 0G4, Canada. [Sjoedin, Andreas] Ctr Dis Control & Prevent, Div Lab Sci, Natl Ctr Environm Hlth, Atlanta, GA 30329 USA. RP Verner, MA (reprint author), Univ Montreal, Sch Publ Hlth, Dept Occupat & Environm Hlth, Montreal, PQ H3T 1J4, Canada. EM marc-andre.verner.1@umontreal.ca FU NIH (NIEHS) [P01 ES0009605, ES017054, ES015572]; NIOSH [OH007400]; Universite de Montreal Public Health Research Institute (IRSPUM); [EPA R82670901]; [RD83171001]; [RD83451301] FX The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention (CDC). Support for this research was provided by the following grants: EPA R82670901, RD83171001, RD83451301; NIH (NIEHS) P01 ES0009605, ES017054, ES015572; NIOSH OH007400. MAV is recipient of an Emerging Researcher Fellowship from the Universite de Montreal Public Health Research Institute (IRSPUM). The authors have no competing interests. MAV and AB have served as consultants on cases unrelated to the issues covered in this paper. A.B. has participated as a member of the Science Advisory Board for The Organic Center, a nonprofit organization that provides information for scientific research about organic food and farming. NR 31 TC 1 Z9 1 U1 3 U2 13 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD MAR 17 PY 2015 VL 49 IS 6 BP 3940 EP 3948 DI 10.1021/acs.est.5b00322 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CD8DC UT WOS:000351324400079 PM 25698216 ER PT J AU Liu, YC Posey, DL Cetron, MS Painter, JA AF Liu, Yecai Posey, Drew L. Cetron, Martin S. Painter, John A. TI Effect of a Culture-Based Screening Algorithm on Tuberculosis Incidence in Immigrants and Refugees Bound for the United States A Population-Based Cross-sectional Study SO ANNALS OF INTERNAL MEDICINE LA English DT Article ID INFECTION; IMPLEMENTATION; RIFAPENTINE AB Background: Before 2007, immigrants and refugees bound for the United States were screened for tuberculosis (TB) by a smear-based algorithm that could not diagnose smear-negative/culture-positive TB. In 2007, the Centers for Disease Control and Prevention implemented a culture-based algorithm. Objective: To evaluate the effect of the culture-based algorithm on preventing the importation of TB to the United States by immigrants and refugees from foreign countries. Design: Population-based, cross-sectional study. Setting: Panel physician sites for overseas medical examination. Patients: Immigrants and refugees with TB. Measurements: Comparison of the increase of smear-negative/culture-positive TB cases diagnosed overseas among immigrants and refugees by the culture-based algorithm with the decline of reported cases among foreign-born persons within 1 year after arrival in the United States from 2007 to 2012. Results: Of the 3 212 421 arrivals of immigrants and refugees from 2007 to 2012, a total of 1 650 961 (51.4%) were screened by the smear-based algorithm and 1 561 460 (48.6%) were screened by the culture-based algorithm. Among the 4032 TB cases diagnosed by the culture-based algorithm, 2195 (54.4%) were smear-negative/culture-positive. Before implementation (2002 to 2006), the annual number of reported cases among foreign-born persons within 1 year after arrival was relatively constant (range, 1424 to 1626 cases; mean, 1504 cases) but decreased from 1511 to 940 cases during implementation (2007 to 2012). During the same period, the annual number of smearnegative/culture-positive TB cases diagnosed overseas among immigrants and refugees bound for the United States by the culture-based algorithm increased from 4 to 629. Limitation: This analysis did not control for the decline in new arrivals of nonimmigrant visitors to the United States and the decrease of incidence of TB in their countries of origin. Conclusion: Implementation of the culture-based algorithm may have substantially reduced the incidence of TB among newly arrived, foreign-born persons in the United States. C1 [Liu, Yecai; Posey, Drew L.; Cetron, Martin S.; Painter, John A.] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA 30333 USA. RP Liu, YC (reprint author), Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, 1600 Clifton Rd,MS-E03, Atlanta, GA 30333 USA. EM yliu@cdc.gov FU Intramural CDC HHS [CC999999] NR 34 TC 7 Z9 7 U1 1 U2 4 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA SN 0003-4819 EI 1539-3704 J9 ANN INTERN MED JI Ann. Intern. Med. PD MAR 17 PY 2015 VL 162 IS 6 BP 420 EP U150 DI 10.7326/M14-2082 PG 14 WC Medicine, General & Internal SC General & Internal Medicine GA CD7OH UT WOS:000351279600015 PM 25775314 ER PT J AU Dale, AM Zeringue, A Harris-Adamson, C Rempel, D Bao, S Thiese, MS Merlino, L Burt, S Kapellusch, J Garg, A Gerr, F Hegmann, KT Eisen, EA Evanoff, B AF Dale, Ann Marie Zeringue, Angelique Harris-Adamson, Carisa Rempel, David Bao, Stephen Thiese, Matthew S. Merlino, Linda Burt, Susan Kapellusch, Jay Garg, Arun Gerr, Fred Hegmann, Kurt T. Eisen, Ellen A. Evanoff, Bradley TI General Population Job Exposure Matrix Applied to a Pooled Study of Prevalent Carpal Tunnel Syndrome SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article DE cross-sectional study; ergonomics; general worker population; job exposure matrix; musculoskeletal disorders; O*NET; pooled study; upper extremity ID 3RD NATIONAL-HEALTH; SURVEY NHANES-III; O-ASTERISK-NET; RISK-FACTORS; BIOMECHANICAL EXPOSURES; WORKING-CONDITIONS; WORKERS; ASSOCIATION; INDUSTRY; EXPERT AB A job exposure matrix may be useful for the study of biomechanical workplace risk factors when individual-level exposure data are unavailable. We used job title-based exposure data from a public data source to construct a job exposurematrix and test exposure-response relationships with prevalent carpal tunnel syndrome (CTS). Exposures of repetitive motion and force from the Occupational Information Network were assigned to 3,452 active workers from several industries, enrolled between 2001 and 2008 from 6 studies. Repetitive motion and force exposures were combined into high/high, high/low, and low/low exposure groupings in each of 4 multivariable logistic regression models, adjusted for personal factors. Although force measures alone were not independent predictors of CTS in these data, strong associations between combined physical exposures of force and repetition and CTS were observed in all models. Consistent with previous literature, this report shows that workers with high force/high repetition jobs had the highest prevalence of CTS (odds ratio = 2.14-2.95) followed by intermediate values (odds ratio = 1.09-2.27) in mixed exposed jobs relative to the lowest exposed workers. This study supports the use of a general population job exposure matrix to estimate workplace physical exposures in epidemiologic studies of musculoskeletal disorders when measures of individual exposures are unavailable. C1 [Dale, Ann Marie; Zeringue, Angelique; Evanoff, Bradley] Washington Univ, Sch Med, Div Gen Med Sci, Dept Med, St Louis, MO 63110 USA. [Harris-Adamson, Carisa; Eisen, Ellen A.] Univ Calif Berkeley, Sch Publ Hlth, Environm Hlth Sci Div, Berkeley, CA 94720 USA. [Harris-Adamson, Carisa] Samuel Merritt Univ, Dept Phys Therapy, Oakland, CA USA. [Rempel, David] Univ Calif San Francisco, Dept Med, Div Occupat & Environm Med, San Francisco, CA USA. [Rempel, David] Univ Calif Berkeley, Coll Engn, Dept Bioengn, Berkeley, CA 94720 USA. [Bao, Stephen] Washington State Dept Labor & Ind, Safety & Hlth Assessment & Res Prevent Program, Olympia, WA 98504 USA. [Thiese, Matthew S.; Hegmann, Kurt T.] Univ Utah, Rocky Mt Ctr Occupat & Environm Hlth, Salt Lake City, UT USA. [Merlino, Linda; Gerr, Fred] Univ Iowa, Coll Publ Hlth, Dept Occupat & Environm Hlth, Iowa City, IA USA. [Burt, Susan] NIOSH, Cincinnati, OH 45226 USA. [Kapellusch, Jay; Garg, Arun] Univ Wisconsin, Ctr Ergon, Milwaukee, WI 53201 USA. RP Dale, AM (reprint author), Washington Univ, Sch Med, Div Gen Med Sci, Campus Box 8005,660 South Euclid Ave, St Louis, MO 63110 USA. EM adale@dom.wustl.edu OI Evanoff, Bradley A./0000-0003-0085-333X FU Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health [R01 OH009712]; Washington University Institute of Clinical and Translational Sciences from the National Center for Advancing Translational Sciences of the National Institutes of Health [UL1 TR000448] FX This work was supported by research funding from the Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health (grant R01 OH009712) and from the Washington University Institute of Clinical and Translational Sciences (award UL1 TR000448) from the National Center for Advancing Translational Sciences of the National Institutes of Health. NR 48 TC 3 Z9 3 U1 1 U2 8 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 EI 1476-6256 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD MAR 15 PY 2015 VL 181 IS 6 BP 431 EP 439 DI 10.1093/aje/kwu286 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CE0QA UT WOS:000351508200009 PM 25700886 ER PT J AU Cegielski, JP Chen, MP Tupasi, TE Leimane, V Volchenkov, GV AF Cegielski, J. Peter Chen, Michael P. Tupasi, Thelma E. Leimane, Vaira Volchenkov, Grigory V. CA Global Preserving Effective TB TI Extensively Drug-Resistant Tuberculosis: You Can Teach an Old Dog New Tricks Reply SO CLINICAL INFECTIOUS DISEASES LA English DT Letter C1 [Cegielski, J. Peter; Chen, Michael P.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Tupasi, Thelma E.] Trop Dis Fdn, Manila, Philippines. [Leimane, Vaira] Riga East Univ, Hosp Ctr TB & Lung Dis, Riga, Latvia. [Volchenkov, Grigory V.] Vladimir Reg TB Dispensary, Moscow, Russia. RP Cegielski, JP (reprint author), Ctr Dis Control & Prevent, Div TB Eliminat, 1600 Clifton Rd NE,MS E-10, Atlanta, GA 30333 USA. EM gzc2@cdc.gov FU Intramural CDC HHS [CC999999] NR 8 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAR 15 PY 2015 VL 60 IS 6 BP 971 EP + DI 10.1093/cid/ciu1150 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CD4KP UT WOS:000351051600028 PM 25527654 ER PT J AU Durham, MD Buchacz, K Armon, C Patel, P Wood, K Brooks, JT AF Durham, Marcus D. Buchacz, Kate Armon, Carl Patel, Pragna Wood, Kathy Brooks, John T. CA HIV Outpatient Study HOPS TI Seasonal Influenza Vaccination Rates in the HIV Outpatient Study-United States, 1999-2013 SO CLINICAL INFECTIOUS DISEASES LA English DT Letter C1 [Durham, Marcus D.; Buchacz, Kate; Patel, Pragna; Brooks, John T.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. [Armon, Carl; Wood, Kathy] Cerner Corp, Vienna, VA USA. RP Durham, MD (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, 1600 Clifton Rd,MS-E45, Atlanta, GA 30333 USA. EM mvd8@cdc.gov FU PHS HHS [200-2006-18797, 200-2001-00133, 200-2011-41872] NR 5 TC 4 Z9 4 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAR 15 PY 2015 VL 60 IS 6 BP 976 EP 977 DI 10.1093/cid/ciu979 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CD4KP UT WOS:000351051600032 PM 25501987 ER PT J AU Li, W Li, YJ Song, MX Lu, YX Yang, JP Tao, W Jiang, YX Wan, Q Zhang, SW Xiao, LH AF Li, Wei Li, Yijing Song, Mingxin Lu, Yixin Yang, Jinping Tao, Wei Jiang, Yanxue Wan, Qiang Zhang, Siwen Xiao, Lihua TI Prevalence and genetic characteristics of Cryptosporidium, Enterocytozoon bieneusi and Giardia duodenalis in cats and dogs in Heilongjiang province, China SO VETERINARY PARASITOLOGY LA English DT Article DE Cryptosporidium; Enterocytozoon bieneusi; Giardia duodenalis; Genotyping; Subtyping ID MOLECULAR CHARACTERIZATION; ZOONOTIC TRANSMISSION; HUMAN INFECTION; FARM DOGS; GENOTYPES; EPIDEMIOLOGY; IDENTIFICATION; ANIMALS; SPP.; ASSEMBLAGES AB This study investigated 319 fecal specimens of cats (n=52) and dogs (n =267) from Heilongjiang province, China for the prevalence and genetic characteristics of Cryptosporidium, Enterocytozoon bieneusi, and Giardia duodenalis. PCR and DNA sequence analysis of the small subunit rRNA gene identified C. felis and C parvum in one cat each (3.8%) and C. canis and C ubiquitum in 6 dogs (2.2%). Polymorphisms in the ribosomal internal transcribed spacer and phylogenetic analysis characterized zoonotic E. bieneusi genotypes D, EbpC, NED1, and NED2 and host-adapted ones NED3, NED4, and PtEb IX in 18 dogs (6.7%) and human-pathogenic genotypes D and IV in 3 cats (5.8%). Genotyping based on the hypermutation of G. duodenalis triosephosphate isomerase gene (TPI) facilitated identification of assemblage F in a cat (1.9%) and assemblages C and E in 12 dogs (4.5%). Subtypes of G. duodenalis isolates were determined by measuring the diversity of both TPI nucleotide and amino acid sequences. C canis, C. fells, C parvum, E. bieneusi genotypes D, EbpC, and IV, and G. duodenalis assemblage C identified herein have been documented in human infections in China. C. canis, C parvum, C. ubiquitum, and E. bieneusi genotypes D, EbpC, and IV carried by cats or dogs also existed in wastewater in China. The finding suggested pet animals could be reservoirs for human cryptosporidiosis, microsporidiosis, and giardiasis and potential sources of water contamination in China. (C) 2015 Elsevier B.V. All rights reserved. C1 [Li, Wei; Li, Yijing; Song, Mingxin; Lu, Yixin; Yang, Jinping; Tao, Wei; Jiang, Yanxue; Wan, Qiang; Zhang, Siwen] Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China. [Xiao, Lihua] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA. RP Li, W (reprint author), Northeast Agr Univ, Coll Vet Med, 59 Mucai St, Harbin 150030, Peoples R China. EM neaulw@gmail.com; lxiao@cdc.gov RI Xiao, Lihua/B-1704-2013; OI Xiao, Lihua/0000-0001-8532-2727; Li, Wei/0000-0002-4264-1864 FU Specialized Research Fund for the Doctoral Program of Higher Education of China [20122325120004]; 7th Special Financial Grant from the China Postdoctoral Science Foundation [2014T70307]; National Natural Science Foundation of China [31302081]; Natural Science Foundation of Heilongjiang Province [QC2013C015]; Heilongjiang Postdoctoral Research Fund [LBH-Z13024] FX This study was supported by the Specialized Research Fund for the Doctoral Program of Higher Education of China (No. 20122325120004), the 7th Special Financial Grant from the China Postdoctoral Science Foundation (No. 2014T70307), the National Natural Science Foundation of China (No. 31302081), the Natural Science Foundation of Heilongjiang Province (No. QC2013C015), and the Heilongjiang Postdoctoral Research Fund (No. LBH-Z13024). NR 46 TC 24 Z9 26 U1 5 U2 22 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-4017 EI 1873-2550 J9 VET PARASITOL JI Vet. Parasitol. PD MAR 15 PY 2015 VL 208 IS 3-4 BP 125 EP 134 DI 10.1016/j.vetpar.2015.01.014 PG 10 WC Parasitology; Veterinary Sciences SC Parasitology; Veterinary Sciences GA CE2KL UT WOS:000351644400003 PM 25665462 ER PT J AU Laatamna, A Wagnerova, P Sak, B Kvetonova, D Xiao, LH Rost, M McEvoy, J Saadi, AR Aissi, M Kvac, M AF Laatamna, Abd Elkarim Wagnerova, Pavia Sak, Bohumil Kvetonova, Dana Xiao, Lihua Rost, Michael McEvoy, John Saadi, Ahmed Rachid Aissi, Meriem Kvac, Martin TI Microsporidia and Cryptosporidium in horses and donkeys in Algeria: Detection of a novel Cryptosporidium hominis subtype family (Ik) in a horse SO VETERINARY PARASITOLOGY LA English DT Article DE Horses; Donkeys; Cryptosporidium spp.; Encephalitozoon spp.; Enterocytozoon bieneusi; Molecular prevalence ID ENTEROCYTOZOON-BIENEUSI; ENCEPHALITOZOON-CUNICULI; EQUINE CRYPTOSPORIDIUM; FOAL DIARRHEA; MOLECULAR CHARACTERIZATION; GIARDIA INFECTIONS; GENETIC DIVERSITY; UNITED-KINGDOM; RISK-FACTORS; C-PARVUM AB A total of 219 and 124 individual fecal samples of horses and donkeys, respectively, were screened for the presence of Cryptosporidium spp., Encephalitozoon spp., and Enterocytozoon bieneusi DNA by genus-specific nested PCR. Isolates were genotyped by sequence analysis of SSU rRNA, GP60, TRAP-C1, COWP, and HSP70 loci in Cryptosporidium, and the ITS region in microsporidia. Cryptosporidium spp. was detected on 3/18 horse farms and 1/15 farms where donkeys were kept. Overall, five (2.3%) horse and two (1.6%) donkey specimens were PCR positive for Cryptosporidium. Genotyping at SSU and GP60 loci revealed that three isolates from horses and donkeys were C. parvum subtype family IIaA16G1R1, one isolate from a horse was, C muris RN66, and one isolate from a donkey was C. muris TS03. An isolate from a horse shared 99.4% and 993% similarity with Cryptosporidium hominis and C. cuniculus, respectively, at the SSU locus. This isolate shared 100% identity with C. hominis at the TRAP-C1, COWP, and HSP70 loci, and it was from the novel gp60 subtype family IkAl1G1. Microsporidia were found on 6/18 horse and 2/15 donkey farms. E. bieneusi was identified in 6.8% (15/219) and 1.6% (2/124), and Encephalitozoon cuniculi was identified in 1.8% (4/219) and 1.6% (2/124), of horses and donkeys, respectively. Three genotypes of E. cuniculi (I, II and III) were detected in horses, and E. cuniculi genotype II was detected in donkeys. Four genotypes of E. bieneusi (horse1, horse 2, CZ3, D) were described in horses. An additional five horses and two donkeys were positive for E. bieneusi, but the isolated were not genotyped. Neither Cryptosporidium nor microsporidia prevalence were affected by sex, age, type of breeding, or whether the host was a horse or a donkey. (C) 2015 Elsevier B.V. All rights reserved. C1 [Laatamna, Abd Elkarim] Univ Djelfa, Fac Nat Sci & Life, Djelfa, Algeria. [Wagnerova, Pavia] Univ South Bohemia Ceske Budejovice, Fac Agr, Ceske Budejovice 37005, Czech Republic. [Wagnerova, Pavia; Sak, Bohumil; Kvetonova, Dana; Kvac, Martin] Acad Sci Czech Republic, Inst Parasitol, Ctr Biol, CR-37005 Ceske Budejovice, Czech Republic. [Xiao, Lihua] Ctr Dis Control & Prevent, Atlanta, GA USA. [Rost, Michael] Univ South Bohemia Ceske Budejovice, Fac Econ, Ceske Budejovice 37005, Czech Republic. [McEvoy, John] N Dakota State Univ, Dept Vet & Microbiol Sci, Fargo, ND 58105 USA. [Laatamna, Abd Elkarim; Saadi, Ahmed Rachid; Aissi, Meriem] Higher Natl Sch Vet, Algiers, Algeria. RP Kvac, M (reprint author), Acad Sci Czech Republic, Ctr Biol, Vvi, Branisovska 31, CR-37005 Ceske Budejovice, Czech Republic. EM kvac@paru.cas.cz RI Kvac, Martin/G-7299-2014; Sak, Bohumil/G-9262-2014; Xiao, Lihua/B-1704-2013 OI Kvac, Martin/0000-0003-0013-6090; Xiao, Lihua/0000-0001-8532-2727 FU Czech Science Foundation [15-01090S]; project of the Grant Agency of University of South Bohemia [011/2013/Z] FX The authors would like to thank Hadouch Zohra (responsible veterinarian in the farm of Tiaret), Samari Housam (private veterinarian in the province of BBA), Badeh Nadir (private veterinarian in the rural area Ouled Braheme) for their participation on material sampling. This study was funded by the Grant of the Czech Science Foundation (15-01090S) and project of the Grant Agency of University of South Bohemia (011/2013/Z). The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the Centers for Disease Control and Prevention or the institutions with which the authors are affiliated. NR 58 TC 11 Z9 12 U1 3 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-4017 EI 1873-2550 J9 VET PARASITOL JI Vet. Parasitol. PD MAR 15 PY 2015 VL 208 IS 3-4 BP 135 EP 142 DI 10.1016/j.vetpar.2015.01.007 PG 8 WC Parasitology; Veterinary Sciences SC Parasitology; Veterinary Sciences GA CE2KL UT WOS:000351644400004 PM 25638716 ER PT J AU Bernstein, DI Atmar, RL Lyon, GM Treanor, JJ Chen, WH Jiang, X Vinje, J Gregoricus, N Frenck, RW Moe, CL Al-Ibrahim, MS Barrett, J Ferreira, J Estes, MK Graham, DY Goodwin, R Borkowski, A Clemens, R Mendelman, PM AF Bernstein, David I. Atmar, Robert L. Lyon, G. Marshall Treanor, John J. Chen, Wilbur H. Jiang, Xi Vinje, Jan Gregoricus, Nicole Frenck, Robert W., Jr. Moe, Christine L. Al-Ibrahim, Mohamed S. Barrett, Jill Ferreira, Jennifer Estes, Mary K. Graham, David Y. Goodwin, Robert Borkowski, Astrid Clemens, Ralf Mendelman, Paul M. TI Norovirus Vaccine Against Experimental Human GII.4 Virus Illness: A Challenge Study in Healthy Adults SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE norovirus; vaccine; challenge; acute gastroenteritis ID CELLULAR IMMUNE-RESPONSES; BLOOD GROUP ANTIGENS; ACUTE GASTROENTERITIS; UNITED-STATES; PARTICLES; IMMUNOGENICITY; VOLUNTEERS; OUTBREAKS; CHILDREN; MUCOSAL AB Background. Vaccines against norovirus, the leading cause of acute gastroenteritis, should protect against medically significant illness and reduce transmission. Methods. In this randomized, double-blind, placebo-controlled trial, 18- to 50-year-olds received 2 injections of placebo or norovirus GI.1/GII.4 bivalent vaccine-like particle (VLP) vaccine with 3-O-desacyl-4'-monophosphoryl lipid A (MPL) and alum. Participants were challenged as inpatients with GII.4 virus (4400 reverse transcription polymerase chain reaction [RT-PCR] units), and monitored for illness and infection. Results. Per protocol, 27 of 50 (54.0%) vaccinees and 30 of 48 (62.5%) controls were infected. Using predefined illness and infection definitions, vaccination did not meet the primary endpoint, but self-reported cases of severe (0% vaccinees vs 8.3% controls; P = .054), moderate or greater (6.0% vs 18.8%; P = .068), and mild or greater severity of vomiting and/or diarrhea (20.0% vs 37.5%; P = .074) were less frequent. Vaccination also reduced the modified Vesikari score from 7.3 to 4.5 (P = .002). Difficulties encountered were low norovirus disease rate, and inability to define illness by quantitative RT-PCR or further antibody rise in vaccinees due to high vaccine-induced titers. By day 10, 11 of 49 (22.4%) vaccinees were shedding virus compared with 17 of 47 (36.2%) placebo recipients (P = .179). Conclusions. Bivalent norovirus VLP vaccine reduced norovirus-related vomiting and/or diarrhea; field efficacy studies are planned. C1 [Bernstein, David I.; Jiang, Xi; Frenck, Robert W., Jr.] Univ Cincinnati, Coll Med, Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45221 USA. [Atmar, Robert L.; Estes, Mary K.; Graham, David Y.] Baylor Coll Med, Houston, TX 77030 USA. [Atmar, Robert L.; Estes, Mary K.; Graham, David Y.] Michael E DeBakey VA Med Ctr, Houston, TX USA. [Lyon, G. Marshall] Emory Univ, Sch Med, Atlanta, GA USA. [Treanor, John J.] Rockefeller Univ, Med Ctr, New York, NY 10021 USA. [Chen, Wilbur H.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA. [Vinje, Jan; Gregoricus, Nicole] Ctr Dis Control & Prevent, Atlanta, GA USA. [Moe, Christine L.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Al-Ibrahim, Mohamed S.] Shin Nippon Biomed Labs, Baltimore, MD USA. [Barrett, Jill; Ferreira, Jennifer] EMMES Corp, Rockville, MD USA. [Goodwin, Robert; Mendelman, Paul M.] Takeda Vaccines Inc, Deerfield, IL USA. [Borkowski, Astrid; Clemens, Ralf] Takeda Pharmaceut Int, Zurich, Switzerland. RP Bernstein, DI (reprint author), Cincinnati Childrens Hosp, 3333 Burnet Ave, Cincinnati, OH 45229 USA. EM david.bernstein@cchmc.org FU Takeda Vaccines, Inc. FX This work was entirely supported by Takeda Vaccines, Inc. NR 25 TC 39 Z9 43 U1 6 U2 31 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD MAR 15 PY 2015 VL 211 IS 6 BP 870 EP 878 DI 10.1093/infdis/jiu497 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CC3CX UT WOS:000350223300005 PM 25210140 ER PT J AU Keenan, JD Klugman, KP McGee, L Vidal, JE Chochua, S Hawkins, P Cevallos, V Gebre, T Tadesse, Z Emerson, PM Jorgensen, JH Gaynor, BD Lietman, TM AF Keenan, Jeremy D. Klugman, Keith P. McGee, Lesley Vidal, Jorge E. Chochua, Sopio Hawkins, Paulina Cevallos, Vicky Gebre, Teshome Tadesse, Zerihun Emerson, Paul M. Jorgensen, James H. Gaynor, Bruce D. Lietman, Thomas M. TI Evidence for Clonal Expansion After Antibiotic Selection Pressure: Pneumococcal Multilocus Sequence Types Before and After Mass Azithromycin Treatments SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE Streptococcus pneumoniae; Africa; MLST; multilocus sequence typing; clonal expansion ID RESISTANT STAPHYLOCOCCUS-AUREUS; STREPTOCOCCUS-PNEUMONIAE; TRACHOMA AB Background. A clinical trial of mass azithromycin distributions for trachoma created a convenient experiment to test the hypothesis that antibiotic use selects for clonal expansion of preexisting resistant bacterial strains. Methods. Twelve communities in Ethiopia received mass azithromycin distributions every 3 months for 1 year. A random sample of 10 children aged 0-9 years from each community was monitored by means of nasopharyngeal swab sampling before mass azithromycin distribution and after 4 mass treatments. Swab specimens were tested for Streptococcus pneumoniae, and isolates underwent multilocus sequence typing. Results. Of 82 pneumococcal isolates identified before treatment, 4 (5%) exhibited azithromycin resistance, representing 3 different sequence types (STs): 177, 6449, and 6494. The proportion of isolates that were classified as one of these 3 STs and were resistant to azithromycin increased after 4 mass azithromycin treatments (14 of 96 isolates [15%]; P = .04). Using a classification index, we found evidence for a relationship between ST and macrolide resistance after mass treatments (P < .0001). The diversity of STs-as calculated by the unbiased Simpson index-decreased significantly after mass azithromycin treatment (P = .045). Conclusions. Resistant clones present before mass azithromycin treatments increased in frequency after treatment, consistent with the theory that antibiotic selection pressure results in clonal expansion of existing resistant strains. C1 [Keenan, Jeremy D.; Cevallos, Vicky; Gaynor, Bruce D.; Lietman, Thomas M.] Univ Calif San Francisco, Francis I Proctor Fdn, San Francisco, CA 94143 USA. [Keenan, Jeremy D.; Gaynor, Bruce D.; Lietman, Thomas M.] Univ Calif San Francisco, Dept Ophthalmol, San Francisco, CA 94143 USA. [Klugman, Keith P.; Vidal, Jorge E.; Chochua, Sopio; Hawkins, Paulina] Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA 30322 USA. [McGee, Lesley; Chochua, Sopio; Hawkins, Paulina] Ctr Dis Control & Prevent, Resp Dis Branch, Atlanta, GA USA. [Emerson, Paul M.] Emory Univ, Carter Ctr, Atlanta, GA 30322 USA. [Jorgensen, James H.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Gebre, Teshome; Tadesse, Zerihun] Carter Ctr, Addis Ababa, Ethiopia. RP Keenan, JD (reprint author), Univ Calif San Francisco, Francis I Proctor Fdn, 513 Parnassus Ave,Box 0412, San Francisco, CA 94143 USA. EM jeremy.keenan@ucsf.edu FU National Institutes of Health [NEI U10 EY016214, NIH/NCRR/OD UCSF-CTSI KL2RR024130, NIH/NEI K23EY019071]; Bernard Osher Foundation; That Man May See; Harper Inglis Trust; Bodri Foundation; South Asia Research Fund; Research to Prevent Blindness; International Trachoma Initiative FX This work was supported by the National Institutes of Health (NEI U10 EY016214, NIH/NCRR/OD UCSF-CTSI KL2RR024130, and NIH/NEI K23EY019071), the Bernard Osher Foundation, That Man May See, the Harper Inglis Trust, the Bodri Foundation, the South Asia Research Fund, Research to Prevent Blindness, and the International Trachoma Initiative (for the azithromycin used for this study). NR 19 TC 5 Z9 5 U1 0 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD MAR 15 PY 2015 VL 211 IS 6 BP 988 EP 994 DI 10.1093/infdis/jiu552 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CC3CX UT WOS:000350223300017 PM 25293366 ER PT J AU Wu, XM Bennett, DH Moran, RE Sjodin, A Jones, RS Tancredi, DJ Tulve, NS Clifton, MS Colon, M Weathers, W Hertz-Picciotto, I AF Wu, Xiangmei (May) Bennett, Deborah H. Moran, Rebecca E. Sjoedin, Andreas Jones, Richard S. Tancredi, Daniel J. Tulve, Nicolle S. Clifton, Matthew Scott Colon, Maribel Weathers, Walter Hertz-Picciotto, Irva TI Polybrominated diphenyl ether serum concentrations in a Californian population of children, their parents, and older adults: an exposure assessment study SO ENVIRONMENTAL HEALTH LA English DT Article DE Children; Flame retardants; PBDEs; Serum concentration; Temporal variability ID HOUSE-DUST; UNITED-STATES; POLYCHLORINATED-BIPHENYLS; FLAME RETARDANTS; MARKET-BASKET; PBDE LEVELS; DIETARY; SAMPLES; ASSOCIATIONS; CONSUMPTION AB Background: Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in many household items. Given concerns over their potential adverse health effects, we identified predictors and evaluated temporal changes of PBDE serum concentrations. Methods: PBDE serum concentrations were measured in young children (2-8 years old; N = 67), parents of young children (<55 years old; N = 90), and older adults (= 55 years old; N = 59) in California, with concurrent floor wipe samples collected in participants' homes in 2008-2009. We also measured serum concentrations one year later in a subset of children (N = 19) and parents (N = 42). Results: PBDE serum concentrations in children were significantly higher than in adults. Floor wipe concentration is a significant predictor of serum BDE-47, 99, 100 and 154. Positive associations were observed between the intake frequency of canned meat and serum concentrations of BDE-47, 99 and 154, between canned meat entrees and BDE-154 and 209, as well as between tuna and white fish and BDE-153. The model with the floor wipe concentration and food intake frequencies explained up to 40% of the mean square prediction error of some congeners. Lower home values and renting (vs. owning) a home were associated with higher serum concentrations of BDE-47, 99 and 100. Serum concentrations measured one year apart were strongly correlated as expected (r = 0.70-0.97) with a slight decreasing trend. Conclusions: Floor wipe concentration, food intake frequency, and housing characteristics can explain 12-40% of the prediction error of PBDE serum concentrations. Decreasing temporal trends should be considered when characterizing long-term exposure. C1 [Wu, Xiangmei (May); Bennett, Deborah H.; Moran, Rebecca E.; Hertz-Picciotto, Irva] Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA. [Sjoedin, Andreas; Jones, Richard S.] Natl Ctr Environm Hlth, Ctr Dis Control & Prevent, Atlanta, GA USA. [Tancredi, Daniel J.] Univ Calif Davis, Dept Pediat, Davis, CA 95616 USA. [Tulve, Nicolle S.; Clifton, Matthew Scott; Colon, Maribel; Weathers, Walter] US EPA, Off Res & Dev, Natl Exposure Res Lab, Human Exposure & Atmospher Sci Div, Res Triangle Pk, NC 27711 USA. RP Bennett, DH (reprint author), Univ Calif Davis, Dept Publ Hlth Sci, One Shields Ave,MS1C, Davis, CA 95616 USA. EM dhbennett@ucdavis.edu FU Science to Achieve Results (STAR) grant from the United States Environmental Protection Agency (US EPA) [RD-83154001]; Autism Speaks; National Institute of Environmental Health Sciences (NIEHS) [R01-ES020392] FX This research was funded by a Science to Achieve Results (STAR) grant #RD-83154001 from the United States Environmental Protection Agency (US EPA). Data analyses were supported by funding from Autism Speaks and the National Institute of Environmental Health Sciences (NIEHS, grant #R01-ES020392). The US EPA, through its Office of Research and Development, partially funded and collaborated in the research described here. This work has been subjected to US EPA Agency administrative review and approved for publication. We are grateful to CDC researchers for their scientific input and serum measurements conducted at the Organic Analytical Toxicology Branch, Division of Laboratory Sciences at the National Center for Environmental Health. The findings and conclusions in this paper are those of the authors and do not necessarily represent the official views or position of the CDC or NIH. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 39 TC 10 Z9 10 U1 1 U2 30 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1476-069X J9 ENVIRON HEALTH-GLOB JI Environ. Health PD MAR 14 PY 2015 VL 14 AR 23 DI 10.1186/s12940-015-0002-2 PG 11 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA CE8OE UT WOS:000352101800001 PM 25884939 ER PT J AU Allemani, C Weir, HK Carreira, H Harewood, R Spika, D Wang, XS Bannon, F Ahn, JV Johnson, CJ Bonaventure, A Marcos-Gragera, R Stiller, C Silva, GAE Chen, WQ Ogunbiyi, OJ Rachet, B Soeberg, MJ You, H Matsuda, T Bielska-Lasota, M Storm, H Tucker, TC Coleman, MP AF Allemani, Claudia Weir, Hannah K. Carreira, Helena Harewood, Rhea Spika, Devon Wang, Xiao-Si Bannon, Finian Ahn, Jane V. Johnson, Christopher J. Bonaventure, Audrey Marcos-Gragera, Rafael Stiller, Charles Azevedo e Silva, Gulnar Chen, Wan-Qing Ogunbiyi, Olufemi J. Rachet, Bernard Soeberg, Matthew J. You, Hui Matsuda, Tomohiro Bielska-Lasota, Magdalena Storm, Hans Tucker, Thomas C. Coleman, Michel P. CA CONCORD Working Grp TI Global surveillance of cancer survival 1995-2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2) SO LANCET LA English DT Article ID HIGH-INCOME COUNTRIES; RECTAL-CANCER; BREAST-CANCER; BENCHMARKING PARTNERSHIP; CHILDHOOD-CANCER; NORDIC COUNTRIES; EUROPE 1999-2007; HIGH-RESOLUTION; OVARIAN-CANCER; NET SURVIVAL AB Background Worldwide data for cancer survival are scarce. We aimed to initiate worldwide surveillance of cancer survival by central analysis of population-based registry data, as a metric of the effectiveness of health systems, and to inform global policy on cancer control. Methods Individual tumour records were submitted by 279 population-based cancer registries in 67 countries for 25.7 million adults (age 15-99 years) and 75 000 children (age 0-14 years) diagnosed with cancer during 1995-2009 and followed up to Dec 31, 2009, or later. We looked at cancers of the stomach, colon, rectum, liver, lung, breast (women), cervix, ovary, and prostate in adults, and adult and childhood leukaemia. Standardised quality control procedures were applied; errors were corrected by the registry concerned. We estimated 5-year net survival, adjusted for background mortality in every country or region by age (single year), sex, and calendar year, and by race or ethnic origin in some countries. Estimates were age-standardised with the International Cancer Survival Standard weights. Findings 5-year survival from colon, rectal, and breast cancers has increased steadily in most developed countries. For patients diagnosed during 2005-09, survival for colon and rectal cancer reached 60% or more in 22 countries around the world; for breast cancer, 5-year survival rose to 85% or higher in 17 countries worldwide. Liver and lung cancer remain lethal in all nations: for both cancers, 5-year survival is below 20% everywhere in Europe, in the range 15-19% in North America, and as low as 7-9% in Mongolia and Thailand. Striking rises in 5-year survival from prostate cancer have occurred in many countries: survival rose by 10-20% between 1995-99 and 2005-09 in 22 countries in South America, Asia, and Europe, but survival still varies widely around the world, from less than 60% in Bulgaria and Thailand to 95% or more in Brazil, Puerto Rico, and the USA. For cervical cancer, national estimates of 5-year survival range from less than 50% to more than 70%; regional variations are much wider, and improvements between 1995-99 and 2005-09 have generally been slight. For women diagnosed with ovarian cancer in 2005-09, 5-year survival was 40% or higher only in Ecuador, the USA, and 17 countries in Asia and Europe. 5-year survival for stomach cancer in 2005-09 was high (54-58%) in Japan and South Korea, compared with less than 40% in other countries. By contrast, 5-year survival from adult leukaemia in Japan and South Korea (18-23%) is lower than in most other countries. 5-year survival from childhood acute lymphoblastic leukaemia is less than 60% in several countries, but as high as 90% in Canada and four European countries, which suggests major deficiencies in the management of a largely curable disease. Interpretation International comparison of survival trends reveals very wide differences that are likely to be attributable to differences in access to early diagnosis and optimum treatment. Continuous worldwide surveillance of cancer survival should become an indispensable source of information for cancer patients and researchers and a stimulus for politicians to improve health policy and health-care systems. C1 [Allemani, Claudia; Carreira, Helena; Harewood, Rhea; Spika, Devon; Wang, Xiao-Si; Ahn, Jane V.; Bonaventure, Audrey; Rachet, Bernard; Coleman, Michel P.] London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, Canc Res UK Canc Survival Grp, London WC1E 7HT, England. [Weir, Hannah K.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA USA. [Bannon, Finian] Queens Univ Belfast, Ctr Publ Hlth, Northern Ireland Canc Registry, Belfast, Antrim, North Ireland. [Johnson, Christopher J.] Canc Data Registry Idaho, Boise, ID USA. [Marcos-Gragera, Rafael] Inst Invest Biomed Girona, Dept Salut, Unitat Epidemiol & Registre Canc Girona, Girona, Spain. [Stiller, Charles] Publ Hlth England, South East Knowledge & Intelligence Team, Oxford, England. [Azevedo e Silva, Gulnar] Univ Estado Rio de Janeiro, Dept Epidemiol, Rio De Janeiro, RJ, Brazil. [Chen, Wan-Qing] Natl Canc Ctr, Natl Off Canc Prevent & Control, Beijing, Peoples R China. [Chen, Wan-Qing] Natl Canc Ctr, Natl Cent Canc Registry, Beijing, Peoples R China. [Ogunbiyi, Olufemi J.] Univ City Coll Hosp, Ibadan Canc Registry, Ibadan, Nigeria. [Soeberg, Matthew J.] Australian Technol Pk, New South Wales Cent Canc Registry, Sydney, NSW, Australia. [You, Hui] Canc Inst NSW, Sydney, NSW, Australia. [Matsuda, Tomohiro] Natl Canc Ctr, Populat Based Canc Registry Sect, Div Surveillance, Ctr Canc Control & Informat Serv, Tokyo 104, Japan. [Bielska-Lasota, Magdalena] Natl Inst Publ Hlth, Dept Hlth Promot & Postgrad Educ, Warsaw, Poland. [Bielska-Lasota, Magdalena] Natl Inst Hyg, PL-00791 Warsaw, Poland. [Storm, Hans] Danish Canc Soc, Canc Prevent & Documentat, Copenhagen, Denmark. [Tucker, Thomas C.] Univ Kentucky, Kentucky Canc Registry, Lexington, KY USA. RP Coleman, MP (reprint author), London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, Canc Res UK Canc Survival Grp, London WC1E 7HT, England. EM concord@lshtm.ac.uk RI SANCHEZ-PEREZ, MARIA JOSE/D-1087-2011; Bhoo-Pathy, Nirmala/C-1228-2010; Katalinic, Alexander/D-2512-2010; Baili, Paolo/J-7422-2016; Belot, Aurelien/N-9287-2016; Gozdz, Stanislaw/D-3300-2013; Curado, Maria Paula/M-6200-2013; OI Marcos-Gragera, Rafael/0000-0001-9824-3657; SANCHEZ-PEREZ, MARIA JOSE/0000-0003-4817-0757; Bhoo-Pathy, Nirmala/0000-0003-0568-8863; Katalinic, Alexander/0000-0003-0490-1554; Baili, Paolo/0000-0003-0335-2418; Belot, Aurelien/0000-0003-1410-5172; Curado, Maria Paula/0000-0001-8172-2483; Coleman, Michel/0000-0001-8940-3807; Spika, Devon/0000-0001-9738-7755; Rachet, Bernard/0000-0001-5837-7773 FU Canadian Partnership Against Cancer (Toronto, Canada); Cancer Focus Northern Ireland (Belfast, UK); Cancer Institute New South Wales (Sydney, Australia); Cancer Research UK (London, UK); Centers for Disease Control and Prevention (Atlanta, GA, USA); Swiss Re (London, UK); Swiss Cancer Research foundation (Bern, Switzerland); Swiss Cancer League (Bern, Switzerland); University of Kentucky (Lexington, KY, USA) FX Canadian Partnership Against Cancer (Toronto, Canada), Cancer Focus Northern Ireland (Belfast, UK), Cancer Institute New South Wales (Sydney, Australia), Cancer Research UK (London, UK), Centers for Disease Control and Prevention (Atlanta, GA, USA), Swiss Re (London, UK), Swiss Cancer Research foundation (Bern, Switzerland), Swiss Cancer League (Bern, Switzerland), and University of Kentucky (Lexington, KY, USA). NR 133 TC 278 Z9 309 U1 11 U2 80 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0140-6736 EI 1474-547X J9 LANCET JI Lancet PD MAR 14 PY 2015 VL 385 IS 9972 BP 977 EP 1010 PG 34 WC Medicine, General & Internal SC General & Internal Medicine GA CD2EK UT WOS:000350886900032 PM 25467588 ER PT J AU Henley, SJ Singh, SD King, J Wilson, R O'Neil, ME Ryerson, AB AF Henley, S. Jane Singh, Simple D. King, Jessica Wilson, Reda O'Neil, Mary Elizabeth Ryerson, A. Blythe TI Invasive Cancer Incidence and Survival - United States, 2011 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Editorial Material C1 [Henley, S. Jane; Singh, Simple D.; King, Jessica; Wilson, Reda; O'Neil, Mary Elizabeth; Ryerson, A. Blythe] CDC, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. RP Henley, SJ (reprint author), CDC, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. EM shenley@cdc.gov NR 9 TC 12 Z9 12 U1 0 U2 2 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAR 13 PY 2015 VL 64 IS 9 BP 237 EP 242 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CE2HF UT WOS:000351635300001 PM 25763875 ER PT J AU Burns, ER Farr, SL Howards, PP AF Burns, Elizabeth R. Farr, Sherry L. Howards, Penelope P. TI Stressful Life Events Experienced by Women in the Year Before Their Infants' Births - United States, 2000-2010 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Editorial Material ID POPULATION-BASED SAMPLE; PREGNANCY; OUTCOMES C1 [Burns, Elizabeth R.; Howards, Penelope P.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Farr, Sherry L.] CDC, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. RP Farr, SL (reprint author), CDC, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. EM bwa0@cdc.gov NR 10 TC 8 Z9 8 U1 3 U2 8 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAR 13 PY 2015 VL 64 IS 9 BP 247 EP 251 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CE2HF UT WOS:000351635300003 PM 25763877 ER PT J AU Iwamoto, M Huang, JY Cronquist, AB Medus, C Hurd, S Zansky, S Dunn, J Woron, AM Oosmanally, N Griffin, PM Besser, J Henao, OL AF Iwamoto, Martha Huang, Jennifer Y. Cronquist, Alicia B. Medus, Carlota Hurd, Sharon Zansky, Shelley Dunn, John Woron, Amy M. Oosmanally, Nadine Griffin, Patricia M. Besser, John Henao, Olga L. TI Bacterial Enteric Infections Detected by Culture-Independent Diagnostic Tests - FoodNet, United States, 2012-2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Editorial Material ID PUBLIC-HEALTH SURVEILLANCE; DISEASES C1 [Iwamoto, Martha; Huang, Jennifer Y.; Griffin, Patricia M.; Besser, John; Henao, Olga L.] CDC, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Cronquist, Alicia B.] Colorado Dept Publ Hlth & Environm, Denver, CO USA. [Medus, Carlota] Minnesota Dept Hlth, St Paul, MN USA. [Hurd, Sharon] Connecticut Dept Publ Hlth, Hartford, CT USA. [Zansky, Shelley] New York State Dept Hlth, Albany, NY 12237 USA. [Dunn, John; Woron, Amy M.] Tennessee Dept Hlth, Columbia, TN USA. [Oosmanally, Nadine] Georgia Dept Publ Hlth, Atlanta, GA USA. RP Iwamoto, M (reprint author), CDC, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. EM miwamoto@cdc.gov NR 9 TC 12 Z9 13 U1 0 U2 4 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAR 13 PY 2015 VL 64 IS 9 BP 252 EP 257 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CE2HF UT WOS:000351635300004 PM 25763878 ER PT J AU Basler, C Forshey, TM Machesky, K Erdman, CM Gomez, TM Brinson, DL Nguyen, TA Behravesh, CB Bosch, S AF Basler, Colin Forshey, Tony M. Machesky, Kimberly Erdman, C. Matthew Gomez, Thomas M. Brinson, Denise L. Thai-An Nguyen Behravesh, Casey Barton Bosch, Stacey TI Multistate Outbreak of Human Salmonella Infections Linked to Live Poultry from a Mail-Order Hatchery in Ohio - February-October 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID MARCH-SEPTEMBER C1 [Basler, Colin] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Basler, Colin; Thai-An Nguyen; Behravesh, Casey Barton; Bosch, Stacey] CDC, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Forshey, Tony M.] Ohio Dept Agr, Reynoldsburg, OH USA. [Machesky, Kimberly] Ohio Dept Hlth, Columbus, OH 43266 USA. [Erdman, C. Matthew; Gomez, Thomas M.; Brinson, Denise L.] USDA, Washington, DC USA. RP Basler, C (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM cbasler@cdc.gov NR 4 TC 3 Z9 3 U1 0 U2 2 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAR 13 PY 2015 VL 64 IS 9 BP 258 EP 258 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CE2HF UT WOS:000351635300005 PM 25763879 ER PT J AU Lin, CY AF Lin, Carol Y. TI Evaluation of using composite HPV genotyping assay results to monitor human papillomavirus infection burden through simulation SO BMC INFECTIOUS DISEASES LA English DT Article DE HPV prevalence; PCR genotyping assay; Vaccine effectiveness; Sensitivity; Specificity ID CERVICAL HUMAN-PAPILLOMAVIRUS; UNITED-STATES; COST-EFFECTIVENESS; NATIONAL-HEALTH; YOUNG-WOMEN; PREVALENCE; RISK; PERFORMANCE; FEMALES; CANCER AB Background: Researchers often group various HPV types into composite measures based on vaccine subtypes, oncogenic potential, or phylogenetic position. Composite prevalence estimates based on PCR genotyping assay results have been calculated to assess HPV infection burden and to monitor HPV vaccine effectiveness. While prevention and intervention strategies can be made based on these prevalence estimates, the discussion on how well these prevalence estimates measure the true underlying infection burdens is limited. Methods: A simulation study was conducted to evaluate accuracy of using composite genotyping assay results to monitor HPV infection burden. Data were generated based on mathematical algorithms with prespecified type-specific infection burdens, assay sensitivity, specificity, and correlations between various HPV types. Estimated-to-true prevalence rate ratios and percent reduction of vaccine types were calculated. Results: When "true" underlying type-specific infection burdens were prespecified as the reported prevalence in U.S. and genotyping assay with sensitivity and specificity (0.95, 0.95) was used, estimated-to-true infection prevalence ratios were 2.35, 2.29, 2.18, and 1.46, for the composite measures with 2 high-risk vaccine, 4 vaccine, 14 high-risk and 37 HPV types, respectively. Estimated-to-true prevalence ratios increased when prespecified "true" underlying infection burdens or assay specificity declined. When prespecified "true" type-specific infections of HPV 6, 11, 16 and 18 were reduced by 50%, the composite prevalence estimate of 4 vaccine types only decreased by 17% which is much lower than 48% reduction in the prespecified "true" composite prevalence. Conclusions: Composite prevalence estimates calculated based on panels of genotyping assay results generally over-estimate the "true" underlying infection burdens and could under-estimate vaccine effectiveness. Analytical specificity of genotyping assay is as or more important than analytical sensitivity and should be considered in selecting assay to monitor HPV. C1 Ctr Dis Control & Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Div STD Prevent, Atlanta, GA 30333 USA. RP Lin, CY (reprint author), Ctr Dis Control & Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Div STD Prevent, 1600 Clifton Rd,NE,MS E-63, Atlanta, GA 30333 USA. EM clin@cdc.gov NR 32 TC 1 Z9 1 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD MAR 12 PY 2015 VL 15 AR 123 DI 10.1186/s12879-015-0851-x PG 12 WC Infectious Diseases SC Infectious Diseases GA CD7IG UT WOS:000351263400001 PM 25880688 ER PT J AU Norman, KN Clawson, ML Strockbine, NA Mandrell, RE Johnson, R Ziebell, K Zhao, SH Fratamico, PM Stones, R Allard, MW Bono, JL AF Norman, Keri N. Clawson, Michael L. Strockbine, Nancy A. Mandrell, Robert E. Johnson, Roger Ziebell, Kim Zhao, Shaohua Fratamico, Pina M. Stones, Robert Allard, Marc W. Bono, James L. TI Comparison of whole genome sequences from human and non-human Escherichia coil 026 strains SO FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY LA English DT Article DE Escherichia coli; O26; Shiga toxins; polymorphisms; phylogenetic ID COLI SEROGROUPS O26; ANTIMICROBIAL RESISTANCE; PHYLOGENETIC ANALYSIS; UNITED-STATES; MINCED BEEF; CATTLE; O111; INFECTIONS; OUTBREAK; O157 AB Shiga toxin-producing Escherichia coil (STEC) O26 is the second leading E co/i serogroup responsible for human illness outbreaks behind E coli O157:H7. Recent outbreaks have been linked to emerging pathogenic O26:H11 strains harboring stx2 only. Cattle have been recognized as an important reservoir of O26 strains harboring stx(1); however the reservoir of these emerging stx(2) strains is unknown. The objective of this study was to identify nucleotide polymorphisms in human and cattle-derived strains in order to compare differences in polymorphism derived genotypes and virulence gene profiles between the two host species. Whole genome sequencing was performed on 182 epidemiologically unrelated O26 strains, including 109 human-derived strains and 73 non-human-derived strains. A panel of 289 O26 strains (241 STEC and 48 non-STEC) was subsequently genotyped using a set of 283 polymorphisms identified by whole genome sequencing, resulting in 64 unique genotypes. Phylogenetic analyses identified seven clusters within the O26 strains. The seven clusters did not distinguish between isolates originating from humans or cattle; however, clusters did correspond with particular virulence gene profiles. Human and non-human-derived strains harboring stx(1) clustered separately from strains harboring stx2, strains harboring eae, and non-STEC strains. Strains harboring stx(2)were more closely related to non-STEC strains and strains harboring eae than to strains harboring stx(1). The finding of human and cattle-derived strains with the same polymorphism derived genotypes and similar virulence gene profiles, provides evidence that similar strains are found in cattle and humans and transmission between the two species may occur. C1 [Norman, Keri N.; Clawson, Michael L.; Bono, James L.] ARS, US Meat Anim Res Ctr, USDA, Clay Ctr, NE 68933 USA. [Strockbine, Nancy A.] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. [Mandrell, Robert E.] ARS, Western Reg Res Ctr, USDA, Albany, CA USA. [Johnson, Roger; Ziebell, Kim] Publ Hlth Agcy Canada, Lab Foodborne Zoonoses, Guelph, ON, Canada. [Zhao, Shaohua] US FDA, Div Anim & Food Microbiol, Ctr Vet Med, Laurel, MD USA. [Fratamico, Pina M.] ARS, Eastern Reg Res Ctr, USDA, Wyndmoor, PA USA. [Stones, Robert] Food & Environm Res Agcy, York, N Yorkshire, England. [Allard, Marc W.] US FDA, Div Microbiol, Ctr Food Safety & Appl Nutr, Off Regulatory Sci, College Pk, MD USA. RP Bono, JL (reprint author), ARS, US Meat Anim Res Ctr, USDA, State Spur 18D,POB 166, Clay Ctr, NE 68933 USA. EM jim.bono@ars.usda.gov FU USDA CSREES NRI FX We would like to thank Sandy Fryda-Bradley, Linda Flathman, and Chris Zimmerman for outstanding technical support. The .sff files for both human and non-human DNA pools have been deposited into the short read archives under BioProject accession PRJNA274335. Some strains used were collected as part of a USDA CSREES NRI grant awarded to Dr. James Keen. The use of product and company names is necessary to accurately report the methods and results; however, the USDA neither guarantees nor warrants the standard of the products, and the use of the names by the USDA implies no approval of the products to the exclusion of others that may also be suitable. USDA is an equal opportunity provider and employer. NR 44 TC 2 Z9 2 U1 1 U2 4 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 2235-2988 J9 FRONT CELL INFECT MI JI Front. Cell. Infect. Microbiol. PD MAR 11 PY 2015 VL 5 AR 21 DI 10.3389/fcimb.2015.00021 PG 10 WC Immunology; Microbiology SC Immunology; Microbiology GA CF3MW UT WOS:000352454000001 PM 25815275 ER PT J AU Amer, S Helal, IB Kamau, E Feng, YY Xiao, LH AF Amer, Said Helal, Ibrahim B. Kamau, Evelyne Feng, Yaoyu Xiao, Lihua TI Molecular Characterization of Echinococcus granulosus Sensu Lato from Farm Animals in Egypt SO PLOS ONE LA English DT Article ID HUMAN CYSTIC ECHINOCOCCOSIS; GENUS ECHINOCOCCUS; NORTH-AFRICA; IDENTIFICATION; STRAINS; HUMANS; SUDAN; EPIDEMIOLOGY; SEQUENCES; ROMANIA AB Little is known on the diversity and public health significance of Echinococcus species in livestock in Egypt. In this study, 37 individual hydatid cysts were collected from dromedary camels (n=28), sheep (n=7) and buffalos (n=2). DNA was extracted from protoscoleces/germinal layer of individual cysts and amplified by PCR targeting nuclear (actin II) and mitochondrial (COX1 and NAD1) genes. Direct sequencing of amplicons indicated the presence of Echinococcus canadenesis (G6 genotype) in 26 of 28 camel cysts, 3 of 7 sheep cysts and the 2 buffalo derived cysts. In contrast, Echinococcus granulosus sensu stricto (G1 genotype) was detected in one cyst from a camel and 4 of 7 cysts from sheep, whereas Echinococcus ortleppi (G5 genotype) was detected in one cyst from a camel. This is the first identification of E. ortleppi in Egypt. C1 [Amer, Said; Xiao, Lihua] Ctr Dis Control & Prevent, Natl Ctr Emerging Zoonot Infect Dis, Div Foodborne Waterborne & Environm Dis, Atlanta, GA USA. [Amer, Said] Kafr El Sheikh Univ, Fac Sci, Dept Zool, Kafr Al Sheikh, Egypt. [Helal, Ibrahim B.] Tanta Univ, Fac Sci, Dept Zool, Tanta, Egypt. [Kamau, Evelyne] Univ Evry Val Essonne, ISSB, Evry, France. [Feng, Yaoyu] E China Univ Sci & Technol, Sch Resources & Environm Engn, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China. RP Feng, YY (reprint author), E China Univ Sci & Technol, Sch Resources & Environm Engn, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China. EM yyfeng@ecust.edu.cn; lxiao@cdc.gov RI Feng, Yaoyu/B-3076-2014; Xiao, Lihua/B-1704-2013 OI Xiao, Lihua/0000-0001-8532-2727 FU Arab Fund for Economic & Social Development "Zamalat Program"; National Natural Science Foundation of China [31110103901] FX This study was supported in part by the Arab Fund for Economic & Social Development "Zamalat Program" and the National Natural Science Foundation of China (Project No. 31110103901). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 49 TC 2 Z9 2 U1 1 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 11 PY 2015 VL 10 IS 3 AR e0118509 DI 10.1371/journal.pone.0118509 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CD7MQ UT WOS:000351275000025 PM 25760944 ER PT J AU Abdulla, S Binka, F Graves, P Greenwood, B Leke, R Malik, E Marsh, K Meek, S Mendis, K Schapira, A Slutsker, L Tanner, M Valecha, N White, N Alonso, P Bosman, A Cibulskis, R D'Souza, B Mnzava, A Patouillard, E Reeder, J Ringwald, P Shutes, E Wongsrichanalai, C AF Abdulla, Salim Binka, Fred Graves, Patricia Greenwood, Brian Leke, Rose Malik, Elfatih Marsh, Kevin Meek, Sylvia Mendis, Kamini Schapira, Allan Slutsker, Laurence Tanner, Marcel Valecha, Neena White, Nicholas Alonso, Pedro Bosman, Andrea Cibulskis, Richard D'Souza, Bianca Mnzava, Abraham Patouillard, Edith Reeder, John Ringwald, Pascal Shutes, Erin Wongsrichanalai, Chansuda CA WHO Malaria Policy Advisory Comm WHO Malaria Policy Advisory Comm S TI Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of sixth biannual meeting (September 2014) SO MALARIA JOURNAL LA English DT Article DE WHO; Malaria; Policy making; Mosquito control; Drug resistance; Surveillance; Elimination; Plasmodium falciparum; Plasmodium vivax ID TRANSMISSION AB The Malaria Policy Advisory Committee to the World Health Organization held its sixth meeting in Geneva, Switzerland from 10 to 12 September 2014. This article provides a summary of the discussions, conclusions and recommendations from that meeting. Meeting sessions covered the following: an update on drug resistance and containment including an assessment on the feasibility of elimination of Plasmodium falciparum malaria in the Greater Mekong Subregion; guidance on the control of residual malaria transmission by behaviourally resistant vectors; progress on the implementation of the Global Plan for Insecticide Resistance Management; updates on the Global Technical Strategy, Global Malaria Action Plan and the Plasmodium vivax technical brief; gaps in current World Health Organization Global Malaria Programme guidance for acceleration to elimination; surveillance, monitoring and evaluation; the updated World Health Organization Guidelines for the Prevention and Treatment of Malaria; Round 5 product testing for rapid diagnostic tests; and Intermittent Preventive Treatment for infants. Policy statements, position statements, and guidelines that arise from the Malaria Policy Advisory Committee meeting conclusions and recommendations will be formally issued and disseminated to World Health Organization Member States by the World Health Organization Global Malaria Programme. C1 [Abdulla, Salim] Ifakara Hlth Inst, Ifakara, Tanzania. [Binka, Fred] Univ Ho, Ho, Ghana. [Graves, Patricia] James Cook Univ, Cairns, Australia. [Greenwood, Brian; D'Souza, Bianca] London Sch Hyg & Trop Med, London WC1, England. [Leke, Rose] Univ Yaounde, Yaounde, Cameroon. [Malik, Elfatih] Minist Hlth, Gezira, Sudan. [Marsh, Kevin] Univ Oxford, Oxford, England. [Meek, Sylvia] Malaria Consortium, London, England. [Slutsker, Laurence] Ctr Dis Control & Prevent, Atlanta, GA USA. [Tanner, Marcel] Swiss Trop & Publ Hlth Inst, Basel, Switzerland. [Valecha, Neena] Natl Inst Malaria Res, New Delhi, India. [White, Nicholas] Mahidol Univ, Bangkok 10700, Thailand. [Alonso, Pedro; Bosman, Andrea; Cibulskis, Richard; D'Souza, Bianca; Mnzava, Abraham; Patouillard, Edith; Reeder, John; Ringwald, Pascal; Shutes, Erin; Wongsrichanalai, Chansuda] WHO, Global Malaria Programme, CH-1211 Geneva 27, Switzerland. RP Alonso, P (reprint author), WHO, Global Malaria Programme, 20 Ave Appia, CH-1211 Geneva 27, Switzerland. EM mpacgmp@who.int FU Bill & Melinda Gates Foundation; UK Department for International Development (DFID); United States Agency for \International Development (USAID) FX The authors gratefully acknowledge the work of the many WHO-GMP staff and others who contributed to the background documents and preparations for the MPAC meeting: from the SME TEG, David Schellenberg from the London School of Hygiene and Tropical Medicine; from the DRC TEG, Arjen Dondorp from Mahidol University, Thailand; on behalf of the VC TEG, Gerry Killeen from the Ifakara Health Institute, Tanzania; and, from the GMAP2 Taskforce, David Brandling-Bennett from the Bill & Melinda Gates Foundation. The authors also thank all the MPAC meeting observers for their contributions during the meeting discussions. The MPAC process is supported in part by grants from the Bill & Melinda Gates Foundation, the UK Department for International Development (DFID), and the United States Agency for \International Development (USAID) to the WHO Global Malaria Programme. NR 31 TC 0 Z9 0 U1 3 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD MAR 10 PY 2015 VL 14 AR 107 DI 10.1186/s12936-015-0623-5 PG 9 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CG3SP UT WOS:000353200200001 ER PT J AU Bann, CM Abresch, RT Biesecker, B Conway, KC Heatwole, C Peay, H Scal, P Strober, J Uzark, K Wolff, J Margolis, M Blackwell, A Street, N Montesanti, A Bolen, J AF Bann, Carla M. Abresch, Richard T. Biesecker, Barbara Conway, Kristin Caspers Heatwole, Chad Peay, Holly Scal, Peter Strober, Jonathan Uzark, Karen Wolff, Jodi Margolis, Marjorie Blackwell, Angela Street, Natalie Montesanti, Angela Bolen, Julie TI Measuring quality of life in muscular dystrophy SO NEUROLOGY LA English DT Article ID PARENT PROXY-REPORTS; CONCEPTUAL-MODEL; NEURO-QOL; CHILDREN; ADOLESCENTS; IMPAIRMENT; DISABILITY; AGREEMENT; TYPE-1; IMPACT AB Objectives: The objectives of this study were to develop a conceptual model of quality of life (QOL) in muscular dystrophies (MDs) and review existing QOL measures for use in the MD population. Methods: Our model for QOL among individuals with MD was developed based on a modified Delphi process, literature review, and input from patients and patient advocacy organizations. Scales that have been used to measure QOL among patients with MD were identified through a literature review and evaluated using the COSMIN (Consensus-Based Standards for the Selection of Health Measurement Instruments) checklist. Results: The Comprehensive Model of QOL in MD (CMQM) captures 3 broad domains of QOL (physical, psychological, and social), includes factors influencing self-reported QOL (disease-related factors, support/resources, and expectations/aspirations), and places these concepts within the context of the life course. The literature review identified 15 QOL scales (9 adult and 6 pediatric) that have been applied to patients with MD. Very few studies reported reliability data, and none included data on responsiveness of the measures to change in disease progression, a necessary psychometric property for measures included in treatment and intervention studies. No scales captured all QOL domains identified in the CMQM model. Conclusions: Additional scale development research is needed to enhance assessment of QOL for individuals with MD. Item banking and computerized adaptive assessment would be particularly beneficial by allowing the scale to be tailored to each individual, thereby minimizing respondent burden. C1 [Bann, Carla M.] RTI Int, Res Triangle Pk, NC 27709 USA. [Abresch, Richard T.] Univ Calif Davis, Davis, CA 95616 USA. [Biesecker, Barbara] NHGRI, Bethesda, MD 20892 USA. [Conway, Kristin Caspers] Univ Iowa, Iowa City, IA USA. [Heatwole, Chad] Univ Rochester, Rochester, NY 14627 USA. [Peay, Holly] Parent Project Muscular Dystrophy, Hackensack, NJ USA. [Scal, Peter] Univ Minnesota, Minneapolis, MN USA. [Strober, Jonathan] UCSF Benioff Childrens Hosp, San Francisco, CA USA. [Uzark, Karen] Univ Michigan, Ann Arbor, MI 48109 USA. [Wolff, Jodi] Muscular Dystrophy Assoc, Chicago, IL USA. [Margolis, Marjorie] Univ N Carolina, Chapel Hill, NC USA. [Blackwell, Angela] RTI Int, Atlanta, GA USA. [Street, Natalie; Montesanti, Angela; Bolen, Julie] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Bann, CM (reprint author), RTI Int, Res Triangle Pk, NC 27709 USA. EM cmb@rti.org FU Centers for Disease Control and Prevention [200-2007-22644/0016] FX Supported by the Centers for Disease Control and Prevention (contract 200-2007-22644/0016). The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 39 TC 3 Z9 3 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0028-3878 EI 1526-632X J9 NEUROLOGY JI Neurology PD MAR 10 PY 2015 VL 84 IS 10 BP 1034 EP 1042 DI 10.1212/WNL.0000000000001336 PG 9 WC Clinical Neurology SC Neurosciences & Neurology GA CD9YR UT WOS:000351458100018 PM 25663223 ER PT J AU Huang, XY Wei, HY Wu, SY Du, YH Liu, LC Su, J Xu, YL Wang, HF Li, XL Wang, YX Liu, GH Chen, WJ Klena, JD Xu, BL AF Huang, Xueyong Wei, Haiyan Wu, Shuyu Du, Yanhua Liu, Licheng Su, Jia Xu, Yuling Wang, Haifeng Li, Xingle Wang, Yanxia Liu, Guohua Chen, Weijun Klena, John David Xu, Bianli TI Epidemiological and Etiological Characteristics of Hand, Foot, and Mouth Disease in Henan, China, 2008-2013 SO SCIENTIFIC REPORTS LA English DT Article ID HUMAN ENTEROVIRUS 71; COXSACKIEVIRUS A16; MOLECULAR EPIDEMIOLOGY; CHILDREN; VACCINE; INFLUENZA; OUTBREAKS; SPREAD; REGION; SPAIN AB Hand, foot, and mouth disease (HFMD) is a common childhood illness caused by enteroviruses. HFMD outbreaks and reported cases have sharply increased in China since 2008. Epidemiological and clinical data of HFMD cases reported in Henan Province were collected from 2008 to 2013. Clinical specimens were obtained from a subset of these cases. Descriptive epidemiological methods were used to analyze the time, region and population distribution. The VP1 gene from EV71 and CA16 isolates was amplified, and the sequences were analyzed. 400,264 cases of HFMD were reported in this study, including 22,309 severe and 141 fatal cases. Incidence peaked between April and May. Laboratory confirmation was obtained for 27,692 (6.9%) cases; EV71, CA16, and other enteroviruses accounted for 59.5%, 14.1%, 26.4%, respectively. Phylogenetic analysis revealed that EV71 belonged to the C4a evolution branch of C4 sub-genotype and CA16 belonged to subtype B1a or B1b. The occurrence of HFMD in Henan was closely related to season, age and region distribution. Children under five were the most affected population. The major pathogens causing HFMD and their genotypes have not notably changed in Henan. The data strongly support the importance of EV71 vaccination in a high population density area such as Henan, China. C1 [Huang, Xueyong; Wei, Haiyan; Du, Yanhua; Su, Jia; Xu, Yuling; Wang, Haifeng; Li, Xingle; Wang, Yanxia; Liu, Guohua; Xu, Bianli] Henan Ctr Dis Control & Prevent, Zhengzhou, Peoples R China. [Huang, Xueyong; Du, Yanhua; Li, Xingle] Henan Key Lab Pathogen Microorganisms, Zhengzhou, Peoples R China. [Wu, Shuyu; Klena, John David] US Ctr Dis Control & Prevent, Int Emerging Infect Program, Beijing, Peoples R China. [Wu, Shuyu; Klena, John David] Ctr Dis Control & Prevent, Div Global Hlth Protect, Global Dis Detect Branch, Ctr Global Hlth, Atlanta, GA USA. [Liu, Licheng; Chen, Weijun] Acad Mil Med Sci, State Key Lab Pathogens & Biosecur, Inst Microbiol & Epidemiol, Beijing, Peoples R China. [Liu, Licheng; Chen, Weijun] Chinese Acad Sci, Beijing Inst Genom, Key Lab Genome Sci & Informat, Beijing, Peoples R China. RP Xu, BL (reprint author), Henan Ctr Dis Control & Prevent, Zhengzhou, Peoples R China. EM bianlixu@163.com FU Henan Province Health Department and National Health and Family Planning Commission of the People's Republic of China [201001015]; Science and Technology Bureau of Henan Province [122102310268] FX This work was supported by Henan Province Health Department and National Health and Family Planning Commission of the People's Republic of China Co-build Project (201001015), and Science and Technology Bureau of Henan Province (122102310268). The authors thank Wendong Liu, Jianwei Sun and Hongxia Ma for their assistance in the laboratory and in preparing this manuscript. NR 47 TC 11 Z9 14 U1 2 U2 13 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD MAR 10 PY 2015 VL 5 AR 8904 DI 10.1038/srep08904 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CD4YF UT WOS:000351091800008 PM 25754970 ER PT J AU Jazwa, A Coleman, MS Gazmararian, J Wingate, LT Maskery, B Mitchell, T Weinberg, M AF Jazwa, Amelia Coleman, Margaret S. Gazmararian, Julie Wingate, La'Marcus T. Maskery, Brian Mitchell, Tarissa Weinberg, Michelle TI Cost-benefit comparison of two proposed overseas programs for reducing chronic Hepatitis B infection among refugees: Is screening essential? SO VACCINE LA English DT Article DE Vaccine; Screening; Hepatitis B virus; Refugee; Cost-benefit ID UNITED-STATES; VIRUS INFECTION; NATURAL-HISTORY; SPECIAL EMPHASIS; EPIDEMIOLOGY; PREVALENCE; IMMUNIZATION; VACCINATION; MINNESOTA; CIRRHOSIS AB Background: Refugees are at an increased risk of chronic Hepatitis B virus (HBV) infection because many of their countries of origin, as well as host countries, have intermediate-to-high prevalence rates. Refugees arriving to the US are also at risk of serious sequelae from chronic HBV infection because they are not routinely screened for the virus overseas or in domestic post-arrival exams, and may live in the US for years without awareness of their infection status. Methods: A cohort of 26,548 refugees who arrived in Minnesota and Georgia during 2005-2010 was evaluated to determine the prevalence of chronic HBV infection. This prevalence information was then used in a cost-benefit analysis comparing two variations of a proposed overseas program to prevent or ameliorate the effects of HBV infection, titled 'Screen, then vaccinate or initiate management' (SVIM) and 'Vaccinate only' (VO). The analyses were performed in 2013. All values were converted to US 2012 dollars. Results: The estimated six year period-prevalence of chronic HBV infection was 6.8% in the overall refugee population arriving to Minnesota and Georgia and 7.1% in those >= 6 years of age. The SVIM program variation was more cost beneficial than VO. While the up-front costs of SVIM were higher than VO ($154,084 vs. $73,758; n=58,538 refugees), the SVIM proposal displayed a positive net benefit, ranging from $24 million to $130 million after only 5 years since program initiation, depending on domestic post-arrival screening rates in the VO proposal. Conclusions: Chronic HBV infection remains an important health problem in refugees resettling to the United States. An overseas screening policy for chronic HBV infection is more cost-beneficial than a 'Vaccination only' policy. The major benefit drivers for the screening policy are earlier medical management of chronic HBV infection and averted lost societal contributions from premature death. Published by Elsevier Ltd. C1 [Jazwa, Amelia; Coleman, Margaret S.; Wingate, La'Marcus T.; Maskery, Brian; Mitchell, Tarissa; Weinberg, Michelle] US Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Global Migrat & Quarantine, Atlanta, GA USA. [Gazmararian, Julie] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. RP Maskery, B (reprint author), 1600 Clifton Rd,MS E-03, Atlanta, GA 30333 USA. EM wqm7@cdc.gov FU Intramural CDC HHS [CC999999] NR 47 TC 1 Z9 1 U1 2 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD MAR 10 PY 2015 VL 33 IS 11 BP 1393 EP 1399 DI 10.1016/j.vaccine.2015.01.010 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA CD2RB UT WOS:000350925600014 PM 25595868 ER PT J AU Potter, RC Flagg, EW Datta, SD Saraiya, M Copeland, G AF Potter, Rachel C. Flagg, Elaine W. Datta, S. Deblina Saraiya, Mona Copeland, Glenn TI Monitoring the impact of human papillomavirus vaccines on high-grade pre-invasive cervical lesions: Designing a framework of linked immunization information system and cancer registry data in Michigan SO VACCINE LA English DT Article DE Human papillomavirus (HPV); HPV vaccine; Cervical cancer; Immunization information system (IIS); Cancer registry ID UNITED-STATES; SURVEILLANCE; VACCINATION; CARCINOMA; AUSTRALIA AB State immunization and cancer registries contain data that, if linked, could be used to monitor the impact of human papillomavirus (HPV) vaccine on cervical cancer and precancer. Michigan is uniquely positioned to examine these outcomes using two population-based resources: the state-wide cancer registry and immunization information system (IIS). We assessed the feasibility of identifying females in the IIS who had continuous Michigan residence and linking them to the cancer registry. We considered continuous residence necessary for future studies of vaccine impact to avoid misclassifying those who may have been immunized while residing out-of-state and whose immunization therefore may not have been reported in Michigan. We identified females with 1976-1996 birthdates in the US and used probabilistic linkage software to match them with Michigan birth records. A stratified random sample of IS-birth matches was provided to a commercial locator service to identify females with continuous Michigan residence. Cervical carcinoma in situ cases diagnosed in 2006 among females aged 10 through 30 years were also matched with the birth records; cancer registry-birth matches were merged with the IS-birth matches using the birth record identifier. Overall, 68% of the 1274,282 IIS and 61% of the 1358 cancer registry records could be matched with birth records. Among the sample of IIS-birth matches, most (86%) were continuous residents. Seventy percent or more of cancer registry-birth matches merged with IIS-birth matches for cases born after 1984. This is the first effort in the U.S. to show that linking records across IIS and cancer registries is practical and reasonably efficient. The increasing proportion of matches between the registries and live birth file with birth year, and the use of population-based data, strengthen the utility of this approach. Future steps include use of this method to examine incidence of cervical cancer precursors in HPV immunization-eligible females. (C) 2015 Published by Elsevier Ltd. C1 [Potter, Rachel C.] Michigan Dept Community Hlth, Div Immunizat, Lansing, MI 48909 USA. [Flagg, Elaine W.; Datta, S. Deblina] Ctr Dis Control & Prevent, Surveillance & Data Management Branch, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Saraiya, Mona] Ctr Dis Control & Prevent, Epidemiol & Appl Res Branch, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Copeland, Glenn] Michigan Dept Community Hlth, Div Vital Records & Hlth Stat, Lansing, MI 48909 USA. RP Potter, RC (reprint author), Michigan Dept Community Hlth, Div Immunizat, 201 Townsend,POB 30195, Lansing, MI 48909 USA. EM potterr1@michigan.gov; eflagg@cdc.gov; ddatta@cdc.gov; msaraiya@cdc.gov; CopelandG@michigan.gov FU immunization grant funds under section 317 of the Public Health Service Act; National Program of Cancer Registries [5U58DP000812, 1U58DP003921] FX This study was supported by immunization grant funds under section 317 of the Public Health Service Act (42 USC Sect. 247b) and National Program of Cancer Registries grant awards 5U58DP000812 and 1U58DP003921. NR 27 TC 1 Z9 1 U1 1 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD MAR 10 PY 2015 VL 33 IS 11 BP 1400 EP 1405 DI 10.1016/j.vaccine.2014.12.063 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA CD2RB UT WOS:000350925600015 PM 25573038 ER PT J AU Kruger, J O'Halloran, A Rosenthal, A AF Kruger, Judy O'Halloran, Alissa Rosenthal, Abby TI Assessment of compliance with US Public Health Service Clinical Practice Guideline for tobacco by primary care physicians SO HARM REDUCTION JOURNAL LA English DT Article DE Smoking cessation; USPHS Clinical Guideline; Tobacco; Primary care physicians; Health professionals ID CESSATION; SMOKING AB Background: The US Public Health Service Clinical Practice Guideline Treating Tobacco Use and Dependence: 2008 Update established an expanded standard of care, calling on physicians to consistently identify their patients who use tobacco and treat them using counseling and medication. Findings: To assess compliance, we examined the extent to which physicians self-report following four of the five components of the 5A model: Ask about tobacco use, Advise patients who use tobacco to quit, Assist the patient in making a quit attempt, and Arrange for follow-up care. We used data from a Web-based panel survey administered to a convenience sample of 1,253 primary care providers (family/general practitioners, internists, and obstetrician/gynecologists). We found that 97.1% of the providers reported that they consistently Asked and documented tobacco use, while 98.6% reported that they consistently Advised their patients to quit using tobacco. Among the family/general practitioners and internists, 98.3% recommended "any" (medication, counseling, counseling and medication, telephone quitline) smoking cessation strategies (Assist). Among all providers, 48.0% reported that they consistently scheduled a follow-up visit (Arrange). Conclusions: This study revealed that most primary care physicians reported that they Ask their patients about tobacco use, Advise them to quit, and Assist them in making a quit attempt, but only half reported that they Arrange a follow-up visit. Tobacco use screening and intervention are among the most effective clinical preventive services; thus, efforts to educate, encourage, and support primary care physicians to provide evidence-based treatments to their patients should be continued. C1 [Kruger, Judy; Rosenthal, Abby] Ctr Dis Control & Prevent, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [O'Halloran, Alissa] Ctr Dis Control & Prevent, Contractor Support NCCDPHP NGIS, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Rosenthal, Abby] Hlth Syst Consulting, Atlanta, GA 30341 USA. RP Kruger, J (reprint author), Ctr Dis Control & Prevent, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, CDC4770 Buford Highway,Bldg 107,F-79, Atlanta, GA 30341 USA. EM jkruger@cdc.gov NR 24 TC 5 Z9 5 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1477-7517 J9 HARM REDUCT J JI Harm Reduct. J. PD MAR 7 PY 2015 VL 12 AR 7 DI 10.1186/s12954-015-0044-3 PG 7 WC Substance Abuse SC Substance Abuse GA CE0DH UT WOS:000351474200001 PM 25889679 ER PT J AU Buchacz, K Chen, MJ Parisi, MK Yoshida-Cervantes, M Antunez, E Delgado, V Moss, NJ Scheer, S AF Buchacz, Kate Chen, Miao-Jung Parisi, Maree Kay Yoshida-Cervantes, Maya Antunez, Erin Delgado, Viva Moss, Nicholas J. Scheer, Susan TI Using HIV Surveillance Registry Data to Re-Link Persons to Care: The RSVP Project in San Francisco SO PLOS ONE LA English DT Article ID NEW-YORK-CITY; UNITED-STATES; ANTIRETROVIRAL THERAPY; PUBLIC-HEALTH; MEDICAL-CARE; PREVENTION; ENGAGEMENT; RETENTION; SUPPRESSION; INFECTION AB Background Persons with unsuppressed HIV viral load (VL) who disengage from care may experience poor clinical outcomes and potentially transmit HIV. We assessed the feasibility and yield of using the San Francisco Department of Public Health (SFDPH) enhanced HIV surveillance system (eHARS) to identify and re-engage such persons in care. Methods Using SFDPH eHARS data as of 4/20/2012 (index date), we selected HIV-infected adults who were alive, had no reported VL or CD4 cell count results in the past nine months (proxy for "out-of-care") and a VL > 200 copies/mL drawn nine to 15 months earlier. We prioritized cases residing locally for investigation, and used information from eHARS and medical and public health databases to contact them for interview and referral to the SFDPH linkage services (LINCS). Twelve months later, we matched-back to eHARS data to assess how HIV laboratory reporting delays affected original eligibility, and if persons had any HIV laboratory results performed and reported within 12 months after index date ('new labs'). Results Among 434 eligible persons, 282 were prioritized for investigation, of whom 75 (27%) were interviewed, 79 (28%) could not be located, and 48 (17%) were located out of the area. Among the interviewed, 54 (72%) persons accepted referral to LINCS. Upon match-back to eHARS data, 324 (75%) in total were confirmed as eligible, including 221 (78%) of the investigated; most had new labs. Conclusions Among the investigated persons presumed out-of-care, we interviewed and offered LINCS referral to about one-quarter, demonstrating the feasibility but limited yield of our project. Matching to updated surveillance data revealed that a substantial minority did not disengage from care and that most re-engaged in HIV care. Verifying persons' HIV care status with medical providers and improving timeliness of transfer and cross-jurisdictional sharing of HIV laboratory data may aid future efforts. C1 [Buchacz, Kate] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. [Chen, Miao-Jung; Parisi, Maree Kay; Yoshida-Cervantes, Maya; Antunez, Erin; Delgado, Viva; Scheer, Susan] San Francisco Dept Publ Hlth, San Francisco, CA 94102 USA. [Moss, Nicholas J.] Alameda Cty Publ Hlth Dept, Oakland, CA USA. RP Scheer, S (reprint author), San Francisco Dept Publ Hlth, San Francisco, CA 94102 USA. EM Susan.Scheer@sfdph.org FU Centers for Disease Control and Prevention (CDC) FX The Centers for Disease Control and Prevention (CDC) provides funding to the San Francisco Department of Public Health and to other state and local health departments in the United States to conduct surveillance of HIV disease in accordance with their own disease reporting regulations. CDC provides technical guidance for the collection of data by the state and local health departments and data are sent to CDC for national-level analyses. Aside from CDC's support to surveillance of HIV disease, the authors received no specific funding for this work. Role of the Sponsors: The CDC reviewed and approved final submission but the findings and conclusions in this report are those of the authors and do not necessarily represent the views of the CDC. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 44 TC 6 Z9 6 U1 0 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 6 PY 2015 VL 10 IS 3 AR e0118923 DI 10.1371/journal.pone.0118923 PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CC9KQ UT WOS:000350689400031 PM 25748668 ER PT J AU Baldwin, PR Reeves, AZ Powell, KR Napier, RJ Swimm, AI Sun, AM Giesler, K Bommarius, B Shinnick, TM Snyder, JP Liotta, DC Kalman, D AF Baldwin, Patrick R. Reeves, Analise Z. Powell, Kimberly R. Napier, Ruth J. Swimm, Alyson I. Sun, Aiming Giesler, Kyle Bommarius, Bettina Shinnick, Thomas M. Snyder, James P. Liotta, Dennis C. Kalman, Daniel TI Monocarbonyl analogs of curcumin inhibit growth of antibiotic sensitive and resistant strains of Mycobacterium tuberculosis SO EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article DE Curcumin; Curcumin analogs; Tuberculosis; Mycobacteria ID MONO-CARBONYL ANALOGS; ANTIINFLAMMATORY AGENTS; ANTICANCER PROPERTIES; DRUG DESIGN; UBS109; DISCOVERY; PATHWAY; EF31 AB Tuberculosis (TB) is a major public health concern worldwide with over 2 billion people currently infected. The rise of strains of Mycobacterium tuberculosis (Mtb) that are resistant to some or all first and second line antibiotics, including multidrug-resistant (MDR), extensively drug resistant (XDR) and totally drug resistant (TDR) strains, is of particular concern and new anti-TB drugs are urgently needed. Curcumin, a natural product used in traditional medicine in India, exhibits anti-microbial activity that includes Mtb, however it is relatively unstable and suffers from poor bioavailability. To improve activity and bioavailability, mono-carbonyl analogs of curcumin were synthesized and screened for their capacity to inhibit the growth of Mtb and the related Mycobacterium marinum (Mm). Using disk diffusion and liquid culture assays, we found several analogs that inhibit in vitro growth of Mm and Mtb, including rifampicin-resistant strains. Structure activity analysis of the analogs indicated that Michael acceptor properties are critical for inhibitory activity. However, no synergistic effects were evident between the monocarbonyl analogs and rifampicin on inhibiting growth. Together, these data provide a structural basis for the development of analogs of curcumin with pronounced anti-mycobacterial activity and provide a roadmap to develop additional structural analogs that exhibit more favorable interactions with other anti-TB drugs. (C) 2015 Elsevier Masson SAS. All rights reserved. C1 [Baldwin, Patrick R.; Sun, Aiming; Giesler, Kyle; Snyder, James P.; Liotta, Dennis C.] Emory Univ, Dept Chem, Atlanta, GA 30322 USA. [Reeves, Analise Z.; Shinnick, Thomas M.] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA. [Reeves, Analise Z.; Napier, Ruth J.] Emory Univ, Microbiol & Mol Genet Grad Program, Atlanta, GA 30322 USA. [Powell, Kimberly R.; Swimm, Alyson I.; Bommarius, Bettina; Kalman, Daniel] Emory Univ, Dept Pathol & Lab Med, Atlanta, GA 30322 USA. RP Kalman, D (reprint author), Emory Univ, Sch Med, 615 Michael St,Whitehead Res Bldg 144, Atlanta, GA 30322 USA. EM dkalman@emory.edu RI Swimm, Alyson/D-1025-2013 FU NIAID NIH HHS [R01 AI072462] NR 38 TC 14 Z9 15 U1 1 U2 21 PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER PI PARIS PA 23 RUE LINOIS, 75724 PARIS, FRANCE SN 0223-5234 EI 1768-3254 J9 EUR J MED CHEM JI Eur. J. Med. Chem. PD MAR 6 PY 2015 VL 92 BP 693 EP 699 DI 10.1016/j.ejmech.2015.01.020 PG 7 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA CD2OO UT WOS:000350919100056 PM 25618016 ER PT J AU D'Mello, T Brammer, L Blanton, L Kniss, K Smith, S Mustaquim, D Steffens, C Dhara, R Cohen, J Chaves, SS Finelli, L Bresee, J Wallis, T Xu, XY Abd Elal, AI Gubareva, L Wentworth, D Villanueva, J Katz, J Jernigan, D AF D'Mello, Tiffany Brammer, Lynnette Blanton, Lenee Kniss, Krista Smith, Sophie Mustaquim, Desiree Steffens, Craig Dhara, Rosaline Cohen, Jessica Chaves, Sandra S. Finelli, Lyn Bresee, Joseph Wallis, Teresa Xu, Xiyan Abd Elal, Anwar Isa Gubareva, Larisa Wentworth, David Villanueva, Julie Katz, Jackie Jernigan, Daniel CA World Hlth Org Collaborating Ctr TI Update: Influenza Activity - United States, September 28, 2014-February 21, 2015 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID SEASONAL INFLUENZA C1 [D'Mello, Tiffany; Brammer, Lynnette; Blanton, Lenee; Kniss, Krista; Smith, Sophie; Mustaquim, Desiree; Steffens, Craig; Dhara, Rosaline; Cohen, Jessica; Chaves, Sandra S.; Finelli, Lyn; Bresee, Joseph; Wallis, Teresa; Xu, Xiyan; Abd Elal, Anwar Isa; Gubareva, Larisa; Wentworth, David; Villanueva, Julie; Katz, Jackie; Jernigan, Daniel] CDC, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP D'Mello, T (reprint author), CDC, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM iqi0@cdc.gov OI Wentworth, David/0000-0002-5190-980X NR 9 TC 25 Z9 26 U1 0 U2 5 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAR 6 PY 2015 VL 64 IS 8 BP 206 EP 212 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CD1LT UT WOS:000350837100002 PM 25742380 ER PT J AU Lind, JN Petersen, EE Lederer, PA Phillips-Bell, GS Perrine, CG Li, RW Hudak, M Correia, JA Creanga, AA Sappenfield, WM Curran, J Blackmore, C Watkins, SM Anjohrin, S AF Lind, Jennifer N. Petersen, Emily E. Lederer, Philip A. Phillips-Bell, Ghasi S. Perrine, Cria G. Li, Ruowei Hudak, Mark Correia, Jane A. Creanga, Andreea A. Sappenfield, William M. Curran, John Blackmore, Carina Watkins, Sharon M. Anjohrin, Suzanne TI Infant and Maternal Characteristics in Neonatal Abstinence Syndrome - Selected Hospitals in Florida, 2010-2011 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID UNITED-STATES; WITHDRAWAL; WOMEN C1 [Lind, Jennifer N.; Petersen, Emily E.; Lederer, Philip A.] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Lind, Jennifer N.; Perrine, Cria G.; Li, Ruowei] CDC, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Lind, Jennifer N.; Petersen, Emily E.; Lederer, Philip A.; Perrine, Cria G.] US Publ Hlth Serv Commissioned Corps, Whiteriver, AZ USA. [Petersen, Emily E.; Phillips-Bell, Ghasi S.; Creanga, Andreea A.] CDC, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Lederer, Philip A.] CDC, Div Global HIV AIDS, Ctr Global Hlth, Atlanta, GA 30333 USA. [Phillips-Bell, Ghasi S.; Correia, Jane A.; Blackmore, Carina; Watkins, Sharon M.; Anjohrin, Suzanne] Florida Dept Hlth, Bradenton, FL USA. [Hudak, Mark] Univ Florida, Coll Med Jacksonville, Gainesville, FL 32611 USA. [Sappenfield, William M.] Univ S Florida, Coll Publ Hlth, Dept Community & Family Hlth, Tampa, FL 33620 USA. [Curran, John] Univ S Florida, Morsani Coll Med, Tampa, FL 33620 USA. RP Lind, JN (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM jlind@cdc.gov NR 10 TC 10 Z9 10 U1 1 U2 4 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAR 6 PY 2015 VL 64 IS 8 BP 213 EP 216 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CD1LT UT WOS:000350837100003 PM 25742381 ER PT J AU Chen, GX Collins, JW Sieber, WK Pratt, SG Rodriguez-Acosta, RL Lincoln, JE Birdsey, J Hitchcock, EM Robinson, CF AF Chen, Guang X. Collins, James W. Sieber, W. Karl Pratt, Stephanie G. Rodriguez-Acosta, Rosa L. Lincoln, Jennifer E. Birdsey, Jan Hitchcock, Edward M. Robinson, Cynthia F. TI Vital Signs: Seat Belt Use Among Long-Haul Truck Drivers - United States, 2010 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID INJURIES AB Background: Motor vehicle crashes were the leading cause of occupational fatalities in the United States in 2012, accounting for 25% of deaths. Truck drivers accounted for 46% of these deaths. This study estimates the prevalence of seat belt use and identifies factors associated with nonuse of seat belts among long-haul truck drivers (LHTDs), a group of workers at high risk for fatalities resulting from truck crashes. Methods: CDC analyzed data from its 2010 national survey of LHTD health and injury. A total of 1,265 drivers completed the survey interview. Logistic regression was used to examine the association between seat belt nonuse and risk factors. Results: An estimated 86.1% of LHTDs reported often using a seat belt, 7.8% used it sometimes, and 6.0% never. Reporting never using a belt was associated with often driving >= 10 mph (16 kph) over the speed limit (adjusted odds ratio [AOR] = 2.9), working for a company with no written safety program (AOR = 2.8), receiving two or more tickets for moving violations in the preceding 12 months (AOR = 2.2), living in a state without a primary belt law (AOR = 2.1); and being female (AOR = 2.3). Conclusions: Approximately 14% of LHTDs are at increased risk for injury and death because they do not use a seat belt on every trip. Safety programs and other management interventions, engineering changes, and design changes might increase seat belt use among LHTDs. Implications for Public Health: Primary state belt laws can help increase belt use among LHTDs. Manufacturers can use recently collected anthropometric data to design better-fitting and more comfortable seat belt systems. C1 [Chen, Guang X.; Collins, James W.; Pratt, Stephanie G.; Rodriguez-Acosta, Rosa L.; Lincoln, Jennifer E.] NIOSH, Div Safety Res, CDC, Atlanta, GA USA. [Sieber, W. Karl; Birdsey, Jan; Robinson, Cynthia F.] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, CDC, Atlanta, GA USA. [Hitchcock, Edward M.] NIOSH, Div Appl Res & Technol, CDC, Atlanta, GA USA. RP Chen, GX (reprint author), NIOSH, Div Safety Res, CDC, Atlanta, GA USA. EM gdc0@cdc.gov NR 14 TC 3 Z9 3 U1 2 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAR 6 PY 2015 VL 64 IS 8 BP 217 EP 221 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CD1LT UT WOS:000350837100004 PM 25742382 ER PT J AU Koonin, LM Jamieson, DJ Jernigan, JA Van Beneden, CA Kosmos, C Harvey, MC Pietz, H Bertolli, J Perz, JF Whitney, CG Halpin, ASL Daley, WR Pesik, N Margolis, GS Tumpey, A Tappero, J Damon, I AF Koonin, Lisa M. Jamieson, Denise J. Jernigan, John A. Van Beneden, Chris A. Kosmos, Christine Harvey, Melissa Cole Pietz, Harald Bertolli, Jeanne Perz, Joseph F. Whitney, Cynthia G. Halpin, Alison Sheehan-Laufer Daley, W. Randolph Pesik, Nicki Margolis, Gregg S. Tumpey, Abbigail Tappero, Jordan Damon, Inger TI Systems for Rapidly Detecting and Treating Persons with Ebola Virus Disease - United States SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Koonin, Lisa M.] CDC, Influenza Coordinat Unit, Off Infect Dis, Atlanta, GA 30333 USA. [Jamieson, Denise J.] CDC, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Jernigan, John A.; Perz, Joseph F.; Halpin, Alison Sheehan-Laufer; Tumpey, Abbigail] CDC, Div Healthcare Qual Promot, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Van Beneden, Chris A.; Whitney, Cynthia G.] CDC, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Kosmos, Christine; Daley, W. Randolph] CDC, Div State & Local Readiness, Off Publ Hlth Preparedness & Response, Atlanta, GA 30333 USA. [Harvey, Melissa Cole] US Dept HHS, Div Natl Healthcare Preparedness Programs, Off Assistant Secretary Preparedness & Response, Atlanta, GA USA. [Pietz, Harald] CDC, Div Publ Hlth Performance Improvement, Off State Tribal Local & Terr Support, Atlanta, GA 30333 USA. [Bertolli, Jeanne] CDC, Div HIV AIDS Prevent Surveillance & Epidemiol, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Pesik, Nicki] CDC, Off Director, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Margolis, Gregg S.] US Dept HHS, Div Hlth Syst Policy, Off Assistant Secretary Preparedness & Response, Atlanta, GA USA. [Tappero, Jordan] CDC, Div Global Hlth Protect, Ctr Global Hlth, Atlanta, GA 30333 USA. [Damon, Inger] CDC, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. RP Koonin, LM (reprint author), CDC, Influenza Coordinat Unit, Off Infect Dis, Atlanta, GA 30333 USA. EM lkoonin@cdc.gov NR 10 TC 3 Z9 3 U1 0 U2 8 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAR 6 PY 2015 VL 64 IS 8 BP 222 EP 225 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CD1LT UT WOS:000350837100005 PM 25742383 ER PT J AU Robyn, MP Hunter, JC Burns, A Newman, AP White, J Clement, EJ Lutterloh, E Quinn, M Edens, C Epstein, L Seiber, K Nguyen, D Kallen, A Blog, D AF Robyn, Misha P. Hunter, Jennifer C. Burns, Amy Newman, Alexandra P. White, Jennifer Clement, Ernest J. Lutterloh, Emily Quinn, Monica Edens, Chris Epstein, Lauren Seiber, Kathy Duc Nguyen Kallen, Alexander Blog, Debra TI Adverse Events Associated with Administration of Simulation Intravenous Fluids to Patients - United States, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Robyn, Misha P.; Hunter, Jennifer C.; Edens, Chris; Epstein, Lauren] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Robyn, Misha P.; Burns, Amy; Newman, Alexandra P.; White, Jennifer; Clement, Ernest J.; Lutterloh, Emily; Quinn, Monica; Blog, Debra] New York State Dept Hlth, Albany, NY 12237 USA. [Hunter, Jennifer C.; Edens, Chris; Epstein, Lauren; Seiber, Kathy; Duc Nguyen; Kallen, Alexander] CDC, Div Healthcare Qual Promot, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. RP Robyn, MP (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM mrobyn@cdc.gov NR 2 TC 0 Z9 0 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAR 6 PY 2015 VL 64 IS 8 BP 226 EP 227 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CD1LT UT WOS:000350837100006 PM 25742384 ER PT J AU Greiner, AL Mamuchishvili, N Salyer, SJ Stauffer, K Geleishvili, M Zakhashvili, K Morgan, J AF Greiner, Ashley L. Mamuchishvili, Nana Salyer, Stephanie J. Stauffer, Kendra Geleishvili, Marika Zakhashvili, Khatuna Morgan, Juliette TI Increase in Reported Crimean-Congo Hemorrhagic Fever Cases - Country of Georgia, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Greiner, Ashley L.] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Greiner, Ashley L.; Salyer, Stephanie J.] CDC, Div Global Hlth Protect, Ctr Global Hlth, Atlanta, GA 30333 USA. [Mamuchishvili, Nana; Zakhashvili, Khatuna] Country Georgia, Natl Ctr Dis Control & Publ Hlth, Atlanta, GA USA. [Stauffer, Kendra; Geleishvili, Marika; Morgan, Juliette] CDC, South Caucasus Country Off, Ctr Global Hlth, Atlanta, GA 30333 USA. RP Greiner, AL (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM agreiner@cdc.gov OI Salyer, Stephanie/0000-0001-7679-2006 NR 7 TC 1 Z9 1 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAR 6 PY 2015 VL 64 IS 8 BP 228 EP 229 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CD1LT UT WOS:000350837100007 ER PT J AU Sullivan, EM Annest, JL Simon, TR Luo, FJ Dahlberg, LL AF Sullivan, Erin M. Annest, Joseph L. Simon, Thomas R. Luo, Feijun Dahlberg, Linda L. TI Suicide Trends Among Persons Aged 10-24 Years - United States, 1994-2012 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID US C1 [Sullivan, Erin M.; Annest, Joseph L.; Luo, Feijun] CDC, Div Anal Res & Practice Integrat, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA. [Simon, Thomas R.; Dahlberg, Linda L.] CDC, Div Violence Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA. RP Simon, TR (reprint author), CDC, Div Violence Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA. EM tsimon@cdc.gov NR 10 TC 0 Z9 0 U1 1 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAR 6 PY 2015 VL 64 IS 8 BP COVER1 EP 205 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CD1LT UT WOS:000350837100001 ER PT J AU Machiela, MJ Zhou, WY Sampson, JN Dean, MC Jacobs, KB Black, A Brinton, LA Chang, IS Chen, C Chen, C Chen, KX Cook, LS Bou, MC De Vivo, I Doherty, J Friedenreich, CM Gaudet, MM Haiman, CA Hankinson, SE Hartge, P Henderson, BE Hong, YC Hosgood, HD Hsiung, CA Hu, W Hunter, DJ Jessop, L Kim, HN Kim, YH Kim, YT Klein, R Kraft, P Lan, Q Lin, DX Liu, JJ Le Marchand, L Liang, XL Lissowska, J Lu, LG Magliocco, AM Matsuo, K Olson, SH Orlow, I Park, JY Pooler, L Prescott, J Rastogi, R Risch, HA Schumacher, F Seow, A Setiawan, VW Shen, HB Sheng, X Shin, MH Shu, XO VanDen Berg, D Wang, JC Wentzensen, N Wong, MP Wu, C Wu, TC Wu, YL Xia, L Yang, HP Yang, PC Zheng, W Zhou, BS Abnet, CC Albanes, D Aldrich, MC Amos, C Amundadottir, LT Berndt, SI Blot, WJ Bock, CH Bracci, PM Burdett, L Buring, JE Butler, MA Carreon, T Chatterjee, N Chung, CC Cook, MB Cullen, M Davis, FG Ding, T Duell, EJ Epstein, CG Fan, JH Figueroa, JD Fraumeni, JF Freedman, ND Fuchs, CS Gao, YT Gapstur, SM Patino-Garcia, A Garcia-Closas, M Gaziano, JM Giles, GG Gillanders, EM Giovannucci, EL Goldin, L Goldstein, AM Greene, MH Hallmans, G Harris, CC Henriksson, R Holly, EA Hoover, RN Hu, N Hutchinson, A Jenab, M Johansen, C Khaw, KT Koh, WP Kolonel, LN Kooperberg, C Krogh, V Kurtz, RC LaCroix, A Landgren, A Landi, MT Li, DH Liao, LM Malats, N McGlynn, KA McNeill, LH McWilliams, RR Melin, BS Mirabello, L Peplonska, B Peters, U Petersen, GM Prokunina-Olsson, L Purdue, M Qiao, YL Rabe, KG Rajaraman, P Real, FX Riboli, E Rodriguez-Santiago, B Rothman, N Ruder, AM Savage, SA Schwartz, AG Schwartz, KL Sesso, HD Severi, G Silverman, DT Spitz, MR Stevens, VL Stolzenberg-Solomon, R Stram, D Tang, ZZ Taylor, PR Teras, LR Tobias, GS Viswanathan, K Wacholder, S Wang, ZM Weinstein, SJ Wheeler, W White, E Wiencke, JK Wolpin, BM Wu, XF Wunder, JS Yu, K Zanetti, KA Zeleniuch-Jacquotte, A Ziegler, RG De Andrade, M Barnes, KC Beaty, TH Bierut, LJ Desch, KC Doheny, KF Feenstra, B Ginsburg, D Heit, JA Kang, JH Laurie, CA Li, JZ Lowe, WL Marazita, ML Melbye, M Mirel, DB Murray, JC Nelson, SC Pasquale, LR Rice, K Wiggs, JL Wise, A Tucker, M Perez-Jurado, LA Laurie, CC Caporaso, NE Yeager, M Chanock, SJ AF Machiela, Mitchell J. Zhou, Weiyin Sampson, Joshua N. Dean, Michael C. Jacobs, Kevin B. Black, Amanda Brinton, Louise A. Chang, I-Shou Chen, Chu Chen, Constance Chen, Kexin Cook, Linda S. Bou, Marta Crous De Vivo, Immaculata Doherty, Jennifer Friedenreich, Christine M. Gaudet, Mia M. Haiman, Christopher A. Hankinson, Susan E. Hartge, Patricia Henderson, Brian E. Hong, Yun-Chul Hosgood, H. Dean, III Hsiung, Chao A. Hu, Wei Hunter, David J. Jessop, Lea Kim, Hee Nam Kim, Yeul Hong Kim, Young Tae Klein, Robert Kraft, Peter Lan, Qing Lin, Dongxin Liu, Jianjun Le Marchand, Loic Liang, Xiaolin Lissowska, Jolanta Lu, Lingeng Magliocco, Anthony M. Matsuo, Keitaro Olson, Sara H. Orlow, Irene Park, Jae Yong Pooler, Loreall Prescott, Jennifer Rastogi, Radhai Risch, Harvey A. Schumacher, Fredrick Seow, Adeline Setiawan, Veronica Wendy Shen, Hongbing Sheng, Xin Shin, Min-Ho Shu, Xiao-Ou VanDen Berg, David Wang, Jiu-Cun Wentzensen, Nicolas Wong, Maria Pik Wu, Chen Wu, Tangchun Wu, Yi-Long Xia, Lucy Yang, Hannah P. Yang, Pan-Chyr Zheng, Wei Zhou, Baosen Abnet, Christian C. Albanes, Demetrius Aldrich, Melinda C. Amos, Christopher Amundadottir, Laufey T. Berndt, Sonja I. Blot, William J. Bock, Cathryn H. Bracci, Paige M. Burdett, Laurie Buring, Julie E. Butler, Mary A. Carreon, Tania Chatterjee, Nilanjan Chung, Charles C. Cook, Michael B. Cullen, Michael Davis, Faith G. Ding, Ti Duell, Eric J. Epstein, Caroline G. Fan, Jin-Hu Figueroa, Jonine D. Fraumeni, Joseph F., Jr. Freedman, Neal D. Fuchs, Charles S. Gao, Yu-Tang Gapstur, Susan M. Patino-Garcia, Ana Garcia-Closas, Montserrat Gaziano, J. Michael Giles, Graham G. Gillanders, Elizabeth M. Giovannucci, Edward L. Goldin, Lynn Goldstein, Alisa M. Greene, Mark H. Hallmans, Goran Harris, Curtis C. Henriksson, Roger Holly, Elizabeth A. Hoover, Robert N. Hu, Nan Hutchinson, Amy Jenab, Mazda Johansen, Christoffer Khaw, Kay-Tee Koh, Woon-Puay Kolonel, Laurence N. Kooperberg, Charles Krogh, Vittorio Kurtz, Robert C. LaCroix, Andrea Landgren, Annelie Landi, Maria Teresa Li, Donghui Liao, Linda M. Malats, Nuria McGlynn, Katherine A. McNeill, Lorna H. McWilliams, Robert R. Melin, Beatrice S. Mirabello, Lisa Peplonska, Beata Peters, Ulrike Petersen, Gloria M. Prokunina-Olsson, Ludmila Purdue, Mark Qiao, You-Lin Rabe, Kari G. Rajaraman, Preetha Real, Francisco X. Riboli, Elio Rodriguez-Santiago, Benjamin Rothman, Nathaniel Ruder, Avima M. Savage, Sharon A. Schwartz, Ann G. Schwartz, Kendra L. Sesso, Howard D. Severi, Gianluca Silverman, Debra T. Spitz, Margaret R. Stevens, Victoria L. Stolzenberg-Solomon, Rachael Stram, Daniel Tang, Ze-Zhong Taylor, Philip R. Teras, Lauren R. Tobias, Geoffrey S. Viswanathan, Kala Wacholder, Sholom Wang, Zhaoming Weinstein, Stephanie J. Wheeler, William White, Emily Wiencke, John K. Wolpin, Brian M. Wu, Xifeng Wunder, Jay S. Yu, Kai Zanetti, Krista A. Zeleniuch-Jacquotte, Anne Ziegler, Regina G. De Andrade, Mariza Barnes, Kathleen C. Beaty, Terri H. Bierut, Laura J. Desch, Karl C. Doheny, Kimberly F. Feenstra, Bjarke Ginsburg, David Heit, John A. Kang, Jae H. Laurie, Cecilia A. Li, Jun Z. Lowe, William L. Marazita, Mary L. Melbye, Mads Mirel, Daniel B. Murray, Jeffrey C. Nelson, Sarah C. Pasquale, Louis R. Rice, Kenneth Wiggs, Janey L. Wise, Anastasia Tucker, Margaret Perez-Jurado, Luis A. Laurie, Cathy C. Caporaso, Neil E. Yeager, Meredith Chanock, Stephen J. TI Characterization of Large Structural Genetic Mosaicism in Human Autosomes SO AMERICAN JOURNAL OF HUMAN GENETICS LA English DT Article ID DETECTABLE CLONAL MOSAICISM; COPY-NUMBER-VARIATION; SOMATIC MOSAICISM; MAFFUCCI SYNDROME; OLLIER DISEASE; HUMAN GENOME; MUTATIONS; CANCER; CELLS; IDENTIFICATION AB Analyses of genome-wide association study (GWAS) data have revealed that detectable genetic mosaicism involving large (>2 Mb) structural autosomal alterations occurs in a fraction of individuals. We present results for a set of 24,849 genotyped individuals (total GWAS set II [TGSII]) in whom 341 large autosomal abnormalities were observed in 168 (0.68%) individuals. Merging data from the new TGSII set with data from two prior reports (the Gene-Environment Association Studies and the total GWAS set I) generated a large dataset of 127,179 individuals; we then conducted a meta-analysis to investigate the patterns of detectable autosomal mosaicism (n = 1,315 events in 925 [0.73%] individuals). Restricting to events >2 Mb in size, we observed an increase in event frequency as event size decreased. The combined results underscore that the rate of detectable mosaicism increases with age (p value = 5.5 x 3 10(-31)) and is higher in men (p value = 0.002) but lower in participants of African ancestry (p value = 0.003). In a subset of 47 individuals from whom serial samples were collected up to 6 years apart, complex changes were noted over time and showed an overall increase in the proportion of mosaic cells as age increased. Our large combined sample allowed for a unique ability to characterize detectable genetic mosaicism involving large structural events and strengthens the emerging evidence of non-random erosion of the genome in the aging population. C1 [Machiela, Mitchell J.; Zhou, Weiyin; Sampson, Joshua N.; Black, Amanda; Brinton, Louise A.; Hartge, Patricia; Hosgood, H. Dean, III; Hu, Wei; Jessop, Lea; Lan, Qing; Wentzensen, Nicolas; Yang, Hannah P.; Abnet, Christian C.; Albanes, Demetrius; Amundadottir, Laufey T.; Berndt, Sonja I.; Burdett, Laurie; Chatterjee, Nilanjan; Chung, Charles C.; Cook, Michael B.; Cullen, Michael; Epstein, Caroline G.; Figueroa, Jonine D.; Fraumeni, Joseph F., Jr.; Freedman, Neal D.; Goldin, Lynn; Goldstein, Alisa M.; Greene, Mark H.; Hoover, Robert N.; Hu, Nan; Hutchinson, Amy; Landgren, Annelie; Landi, Maria Teresa; Liao, Linda M.; McGlynn, Katherine A.; Mirabello, Lisa; Prokunina-Olsson, Ludmila; Purdue, Mark; Rajaraman, Preetha; Rothman, Nathaniel; Savage, Sharon A.; Silverman, Debra T.; Stolzenberg-Solomon, Rachael; Taylor, Philip R.; Tobias, Geoffrey S.; Wacholder, Sholom; Wang, Zhaoming; Weinstein, Stephanie J.; Yu, Kai; Ziegler, Regina G.; Tucker, Margaret; Caporaso, Neil E.; Yeager, Meredith; Chanock, Stephen J.] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA. [Zhou, Weiyin; Jacobs, Kevin B.; Burdett, Laurie; Chung, Charles C.; Cullen, Michael; Hutchinson, Amy; Wang, Zhaoming; Yeager, Meredith] NCI, Canc Genom Res Lab, Div Canc Epidemiol & Genet, NIH,Leidos Biomed Res Inc, Bethesda, MD 20892 USA. [Dean, Michael C.] NCI, Expt Immunol Lab, Ctr Canc Res, NIH, Frederick, MD 21702 USA. [Jacobs, Kevin B.] BioInformed LLC, Gaithersburg, MD 20877 USA. [Chang, I-Shou] Natl Inst Canc Res, Natl Hlth Res Inst, Zhunan 35053, Taiwan. [Chen, Chu; Kooperberg, Charles; LaCroix, Andrea; Peters, Ulrike; White, Emily] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA. [Chen, Constance; Bou, Marta Crous; De Vivo, Immaculata; Hunter, David J.; Kraft, Peter; Prescott, Jennifer] Harvard Univ, Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA 02115 USA. [Chen, Kexin] Tianjin Med Univ, Canc Inst & Hosp, Dept Epidemiol & Biostat, Tianjin 300040, Peoples R China. [Cook, Linda S.] Univ New Mexico, Albuquerque, NM 87131 USA. [Bou, Marta Crous; De Vivo, Immaculata; Hankinson, Susan E.; Hunter, David J.; Prescott, Jennifer; Fuchs, Charles S.; Giovannucci, Edward L.; Wolpin, Brian M.; Kang, Jae H.; Pasquale, Louis R.] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA. [Bou, Marta Crous; De Vivo, Immaculata; Hankinson, Susan E.; Hunter, David J.; Prescott, Jennifer; Fuchs, Charles S.; Gaziano, J. Michael; Giovannucci, Edward L.; Wolpin, Brian M.; Kang, Jae H.; Pasquale, Louis R.] Harvard Univ, Sch Med, Boston, MA 02115 USA. [Doherty, Jennifer] Dartmouth Coll, Geisel Sch Med, Hanover, NH 03755 USA. [Friedenreich, Christine M.] Alberta Hlth Serv, CancerControl Alberta, Dept Populat Hlth Res, Calgary, AB T2N 2T9, Canada. [Gaudet, Mia M.; Gapstur, Susan M.; Stevens, Victoria L.; Teras, Lauren R.] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30303 USA. [Haiman, Christopher A.; Henderson, Brian E.; Schumacher, Fredrick; Setiawan, Veronica Wendy; VanDen Berg, David; Stram, Daniel] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA. [Hankinson, Susan E.] Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Div Biostat & Epidemiol, Amherst, MA 01003 USA. [Hong, Yun-Chul] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul 151742, South Korea. [Hosgood, H. Dean, III] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10461 USA. [Hsiung, Chao A.] Inst Populat Hlth Sci, Natl Hlth Res Inst, Zhunan 35053, Taiwan. [Hunter, David J.; Mirel, Daniel B.] Broad Inst Harvard & MIT, Cambridge, MA 02142 USA. [Kim, Hee Nam] Chonnam Natl Univ, Ctr Creat Biomed Scientists, Kwangju 500757, South Korea. [Kim, Yeul Hong] Korea Univ, Anam Hosp, Coll Med, Div Oncol Hematol,Dept Internal Med, Seoul 151742, South Korea. [Kim, Young Tae] Seoul Natl Univ, Coll Med, Dept Thorac & Cardiovasc Surg, Canc Res Inst, Seoul 151742, South Korea. [Klein, Robert] Mem Sloan Kettering Canc Ctr, Program Canc Biol & Genet, New York, NY 10065 USA. [Lin, Dongxin; Wu, Chen] Chinese Acad Med Sci, Canc Inst & Hosp, Dept Etiol & Carcinogenesis, Beijing 100730, Peoples R China. [Lin, Dongxin; Wu, Chen] Peking Union Med Coll, Beijing 100730, Peoples R China. [Lin, Dongxin; Wu, Chen] Chinese Acad Med Sci, Canc Inst & Hosp, State Key Lab Mol Oncol, Beijing 100730, Peoples R China. [Liu, Jianjun] Genome Inst Singapore, Dept Human Genet, Singapore 138672, Singapore. [Liu, Jianjun] Anhui Med Univ, Sch Life Sci, Hefei 230032, Peoples R China. [Le Marchand, Loic; Kolonel, Laurence N.] Univ Hawaii, Ctr Canc, Program Epidemiol, Honolulu, HI 96813 USA. [Liang, Xiaolin; Olson, Sara H.; Orlow, Irene; Rastogi, Radhai] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10065 USA. [Lissowska, Jolanta] Maria Sklodowska Curie Canc Ctr, Dept Canc Epidemiol & Prevent, PL-02781 Warsaw, Poland. [Lissowska, Jolanta] Inst Oncol, PL-02781 Warsaw, Poland. [Lu, Lingeng; Risch, Harvey A.] Yale Univ, Sch Publ Hlth, New Haven, CT 06510 USA. [Magliocco, Anthony M.] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA. [Matsuo, Keitaro] Kyushu Univ, Fac Med Sci, Dept Prevent Med, Fukuoka 8190395, Japan. [Park, Jae Yong] Kyungpook Natl Univ, Med Ctr, Lung Canc Ctr, Daegu 101, South Korea. [Pooler, Loreall; Sheng, Xin; Xia, Lucy] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90007 USA. [Seow, Adeline; Koh, Woon-Puay] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 119077, Singapore. [Shen, Hongbing] Nanjing Med Univ, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Nanjing 210029, Jiangsu, Peoples R China. [Shen, Hongbing] Nanjing Med Univ, Minist Educ, Key Lab Modern Toxicol, Nanjing 210029, Jiangsu, Peoples R China. [Shin, Min-Ho] Chonnam Natl Univ, Sch Med, Dept Prevent Med, Gwanju 501746, South Korea. [Shu, Xiao-Ou] Vanderbilt Univ, Med Ctr, Vanderbilt Ingram Canc Ctr, Dept Med,Vanderbilt Epidemiol Ctr, Nashville, TN 37232 USA. [Wang, Jiu-Cun] Fudan Univ, Sch Life Sci, Key Lab Contemporary Anthropol, Minist Educ, Shanghai 200433, Peoples R China. [Wang, Jiu-Cun] Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China. [Wong, Maria Pik] Univ Hong Kong, Li Ka Shing Fac Med, Dept Pathol, Hong Kong, Hong Kong, Peoples R China. [Wu, Tangchun] Huazhong Univ Sci & Technol, Sch Publ Hlth, Inst Occupat Med, Wuhan 430400, Peoples R China. [Wu, Tangchun] Huazhong Univ Sci & Technol, Sch Publ Hlth, Minist Educ, Key Lab Environm & Hlth, Wuhan 430400, Peoples R China. [Wu, Yi-Long] Guangdong Gen Hosp, Guangdong Lung Canc Inst, Guangzhou 515200, Guangdong, Peoples R China. [Wu, Yi-Long] Guangdong Acad Med Sci, Guangzhou 515200, Guangdong, Peoples R China. [Yang, Pan-Chyr] Natl Taiwan Univ, Dept Internal Med, Coll Med, Taipei 10617, Taiwan. [Zheng, Wei; Aldrich, Melinda C.; Blot, William J.] Vanderbilt Univ, Med Ctr, Vanderbilt Epidemiol Ctr, Div Epidemiol,Dept Med, Nashville, TN 37232 USA. [Zhou, Baosen] China Med Univ, Sch Publ Hlth, Dept Epidemiol, Shenyang 110001, Peoples R China. [Aldrich, Melinda C.] Vanderbilt Univ, Sch Med, Dept Thorac Surg, Nashville, TN 37232 USA. [Amos, Christopher] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Div Canc Prevent & Populat Sci, Houston, TX 77030 USA. [Blot, William J.] Int Epidemiol Inst, Rockville, MD 20850 USA. [Bock, Cathryn H.; Schwartz, Ann G.] Wayne State Univ, Sch Med, Karmanos Canc Inst, Detroit, MI 48201 USA. [Bock, Cathryn H.; Schwartz, Ann G.] Wayne State Univ, Sch Med, Dept Oncol, Detroit, MI 48201 USA. [Bracci, Paige M.; Holly, Elizabeth A.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. [Buring, Julie E.; Sesso, Howard D.] Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA. [Butler, Mary A.; Carreon, Tania; Ruder, Avima M.] NIOSH, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Davis, Faith G.] Univ Alberta, Sch Publ Hlth, Dept Publ Hlth Sci, Edmonton, AB T6G 2R3, Canada. [Ding, Ti; Tang, Ze-Zhong] Shanxi Canc Hosp, Taiyuan 030013, Shanxi, Peoples R China. [Duell, Eric J.] Catalan Inst Oncol, Bellvitge Biomed Res Inst, Canc Epidemiol Res Program, Unit Nutr Environm & Canc, Barcelona 08908, Spain. [Fan, Jin-Hu] Shanghai Canc Inst, Shanghai 200032, Peoples R China. [Fuchs, Charles S.; Wolpin, Brian M.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA. [Gao, Yu-Tang] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Epidemiol,Shanghai Canc Inst, Shanghai 200032, Peoples R China. [Patino-Garcia, Ana] Univ Navarra, Univ Navarra Clin, Dept Pediat, E-31080 Pamplona, Spain. [Garcia-Closas, Montserrat] Inst Canc Res, Div Genet & Epidemiol, London SM2 5NG, Surrey, England. [Garcia-Closas, Montserrat] Inst Canc Res, Breakthrough Breast Canc Res Ctr, London SM2 5NG, Surrey, England. [Gaziano, J. Michael] Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA. [Gaziano, J. Michael] Brigham & Womens Hosp, Dept Med, Div Aging, Boston, MA 02115 USA. [Gaziano, J. Michael] Vet Affairs Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr, Boston, MA 02130 USA. [Gaziano, J. Michael] Vet Affairs Boston Healthcare Syst, Cooperat Studies Programs, Boston, MA 02130 USA. [Giles, Graham G.; Severi, Gianluca] Univ Melbourne, Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic 3010, Australia. [Giles, Graham G.; Severi, Gianluca] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic 3010, Australia. [Gillanders, Elizabeth M.; Zanetti, Krista A.] NCI, Div Canc Control & Populat Sci, NIH, Bethesda, MD 20892 USA. [Giovannucci, Edward L.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Hallmans, Goran] Umea Univ, Dept Publ Hlth & Clin Med, Nutr Res Unit, S-90187 Umea, Sweden. [Harris, Curtis C.] NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [Henriksson, Roger; Melin, Beatrice S.] Umea Univ, Dept Radiat Sci, Dept Oncol, S-90187 Umea, Sweden. [Jenab, Mazda] Int Agcy Res Canc, F-69372 Lyon, France. [Johansen, Christoffer] Rigshosp, Finsen Ctr, Dept Oncol, DK-2100 Copenhagen, Denmark. [Johansen, Christoffer] Danish Canc Soc, Res Ctr, Unit Survivorship Res, DK-2100 Copenhagen, Denmark. [Khaw, Kay-Tee] Univ Cambridge, Sch Clin Med, Cambridge CB2 1TN, England. [Koh, Woon-Puay] Duke NUS Grad Med Sch, Singapore 169857, Singapore. [Krogh, Vittorio] Fdn IRCCS Ist Nazl Tumori, I-20133 Milan, Italy. [Kurtz, Robert C.] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA. [Li, Donghui] Univ Texas MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Houston, TX 77030 USA. [Malats, Nuria; Real, Francisco X.] Spanish Natl Canc Res Ctr, Madrid 28029, Spain. [McNeill, Lorna H.] Univ Texas MD Anderson Canc Ctr, Dept Hlth Dispar Res, Div OVP Canc Prevent & Populat Sci, Houston, TX 77030 USA. [McNeill, Lorna H.] Univ Texas MD Anderson Canc Ctr, Ctr Community Engaged Translat Res, Duncan Family Inst, Houston, TX 77030 USA. [McWilliams, Robert R.] Mayo Clin, Dept Oncol, Rochester, MN 55905 USA. [Peplonska, Beata] Nofer Inst Occupat Med, PL-91348 Lodz, Poland. [Petersen, Gloria M.; Rabe, Kari G.; De Andrade, Mariza] Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA. [Qiao, You-Lin] Chinese Acad Med Sci, Inst Canc, Dept Epidemiol, Beijing 100730, Peoples R China. [Real, Francisco X.; Rodriguez-Santiago, Benjamin; Perez-Jurado, Luis A.] Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Barcelona 08003, Spain. [Riboli, Elio] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Div Epidemiol & Biostat, London SW7 2AZ, England. [Rodriguez-Santiago, Benjamin; Perez-Jurado, Luis A.] Ctr Invest Biomed Red Enfermedades Raras, Barcelona 08003, Spain. [Rodriguez-Santiago, Benjamin] QGenomics, Quantitat Genom Med Lab, Barcelona 08003, Spain. [Schwartz, Kendra L.] Wayne State Univ, Sch Med, Karmanos Canc Inst, Detroit, MI 48201 USA. [Schwartz, Kendra L.] Wayne State Univ, Sch Med, Dept Family Med & Publ Hlth Sci, Detroit, MI 48201 USA. [Severi, Gianluca] Human Genet Fdn, I-10126 Turin, Italy. [Spitz, Margaret R.] Baylor Coll Med, Houston, TX 77030 USA. [Viswanathan, Kala; Beaty, Terri H.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21218 USA. [Wheeler, William] Informat Management Serv Inc, Calverton, MD 20904 USA. [Wiencke, John K.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Wu, Xifeng] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA. [Wunder, Jay S.] Washington Univ, Sch Med, Div Urol Surg, St Louis, MO 63110 USA. [Zeleniuch-Jacquotte, Anne] NYU, Sch Med, Dept Populat Hlth, New York, NY 10016 USA. [Zeleniuch-Jacquotte, Anne] NYU, Perlmutter Canc Inst, New York, NY 10016 USA. [Barnes, Kathleen C.] Johns Hopkins Univ, Sch Med, Baltimore, MD 21218 USA. [Bierut, Laura J.] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA. [Desch, Karl C.] Univ Michigan, Dept Pediat & Communicable Dis, CS Mott Childrens Hosp, Ann Arbor, MI 48109 USA. [Doheny, Kimberly F.] Johns Hopkins Univ, Inst Med Genet, Sch Med, Ctr Inherited Dis Res, Baltimore, MD 21218 USA. [Feenstra, Bjarke; Melbye, Mads] Statens Serum Inst, Dept Epidemiol Res, DK-2300 Copenhagen, Denmark. [Ginsburg, David] Univ Michigan, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA. [Ginsburg, David] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA. [Heit, John A.] Mayo Clin, Dept Internal Med, Rochester, MN 55905 USA. [Laurie, Cecilia A.; Nelson, Sarah C.; Rice, Kenneth; Laurie, Cathy C.] Univ Washington, Dept Biostat, Seattle, WA 98195 USA. [Li, Jun Z.] Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA. [Lowe, William L.] Northwestern Univ, Feinberg Sch Med, Div Endocrinol Metab & Mol Med, Evanston, IL 60208 USA. [Marazita, Mary L.] Univ Pittsburgh, Sch Dent Med, Dept Oral Biol, Ctr Craniofacial & Dent Genet, Pittsburgh, PA 15260 USA. [Marazita, Mary L.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA 15260 USA. [Melbye, Mads] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA. [Murray, Jeffrey C.] Univ Iowa, Dept Pediat, Iowa City, IA 52242 USA. [Pasquale, Louis R.; Wiggs, Janey L.] Harvard Univ, Dept Ophthalmol, Massachusetts Eye & Ear Infirm, Boston, MA 02114 USA. [Wise, Anastasia] NHGRI, Off Populat Genom, NIH, Bethesda, MD 20892 USA. [Perez-Jurado, Luis A.] Hosp del Mar, Res Inst, Barcelona 08003, Spain. RP Chanock, SJ (reprint author), NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA. EM chanocks@mail.nih.gov RI Savage, Sharon/B-9747-2015; Krogh, Vittorio/K-2628-2016; Tobias, Geoffrey/M-4135-2016; Qiao, You-Lin/B-4139-2012; Hsiung, Chao Agnes/E-3994-2010; Garcia-Closas, Montserrat /F-3871-2015; Chang, I-Shou/D-2084-2010; Brinton, Louise/G-7486-2015; Freedman, Neal/B-9741-2015; Abnet, Christian/C-4111-2015; Malats, Nuria/H-7041-2015; Patino-Garcia, Ana/I-4299-2012; Perez Jurado, Luis Alberto/M-7706-2015; Real Arribas, Francisco/H-5275-2015; Cook, Michael/A-5641-2009; U-ID, Kyushu/C-5291-2016; OI Savage, Sharon/0000-0001-6006-0740; Krogh, Vittorio/0000-0003-0122-8624; Tobias, Geoffrey/0000-0002-2878-8253; Qiao, You-Lin/0000-0001-6380-0871; Nelson, Sarah/0000-0002-2109-6465; Rodriguez-Santiago, Benjamin/0000-0003-1167-3852; YANG, PAN-CHYR/0000-0001-6330-6048; Prokunina-Olsson, Ludmila/0000-0002-9622-2091; Liao, Linda/0000-0002-1923-5294; Machiela, Mitchell/0000-0001-6538-9705; Garcia-Closas, Montserrat /0000-0003-1033-2650; Brinton, Louise/0000-0003-3853-8562; Freedman, Neal/0000-0003-0074-1098; Abnet, Christian/0000-0002-3008-7843; Malats, Nuria/0000-0003-2538-3784; Real Arribas, Francisco/0000-0001-9501-498X; Cook, Michael/0000-0002-0533-7302; Orlow, Irene/0000-0001-6234-6961; Giles, Graham/0000-0003-4946-9099; Zeleniuch-Jacquotte, Anne/0000-0001-9350-1303; Matsuo, Keitaro/0000-0003-1761-6314 FU Medical Research Council [G0401527, G1000143]; NCI NIH HHS [R01 CA124908, K05 CA154337, K07 CA172294, P01 CA087969, P30 CA008748, P30 CA016672, P30 CA023108, R01 CA092447, R25 CA174664, UM1 CA182934]; NEI NIH HHS [P30 EY014104, R01 EY015473, R01 EY022305]; NHLBI NIH HHS [R01 HL039693, R01 HL112642]; NIDCR NIH HHS [R01 DE014899, R01 DE016148] NR 35 TC 14 Z9 14 U1 2 U2 17 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0002-9297 EI 1537-6605 J9 AM J HUM GENET JI Am. J. Hum. Genet. PD MAR 5 PY 2015 VL 96 IS 3 BP 487 EP 497 DI 10.1016/j.ajhg.2015.01.011 PG 11 WC Genetics & Heredity SC Genetics & Heredity GA CD0GD UT WOS:000350747800022 PM 25748358 ER PT J AU Teshale, E Ward, JW AF Teshale, Eyasu Ward, John W. TI Making Hepatitis E a Vaccine-Preventable Disease SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Editorial Material ID INFECTION; BURDEN C1 [Teshale, Eyasu; Ward, John W.] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA USA. RP Teshale, E (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA USA. NR 5 TC 4 Z9 5 U1 0 U2 4 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD MAR 5 PY 2015 VL 372 IS 10 BP 899 EP 901 DI 10.1056/NEJMp1415240 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA CC4EU UT WOS:000350304500004 PM 25738664 ER PT J AU Reed, C Chaves, SS Kirley, PD Emerson, R Aragon, D Hancock, EB Butler, L Baumbach, J Hollick, G Bennett, NM Laidler, MR Thomas, A Meltzer, MI Finelli, L AF Reed, Carrie Chaves, Sandra S. Kirley, Pam Daily Emerson, Ruth Aragon, Deborah Hancock, Emily B. Butler, Lisa Baumbach, Joan Hollick, Gary Bennett, Nancy M. Laidler, Matthew R. Thomas, Ann Meltzer, Martin I. Finelli, Lyn TI Estimating Influenza Disease Burden from Population-Based Surveillance Data in the United States SO PLOS ONE LA English DT Article ID SEASONAL INFLUENZA; HOSPITALIZATIONS; VIRUS; CHILDREN; VACCINE; INFECTION; DEATHS AB Annual estimates of the influenza disease burden provide information to evaluate programs and allocate resources. We used a multiplier method with routine population-based surveillance data on influenza hospitalization in the United States to correct for under-reporting and estimate the burden of influenza for seasons after the 2009 pandemic. Five sites of the Influenza Hospitalization Surveillance Network (FluSurv-NET) collected data on the frequency and sensitivity of influenza testing during two seasons to estimate under-detection. Population-based rates of influenza-associated hospitalization and Intensive Care Unit admission from 2010-2013 were extrapolated to the U. S. population from FluSurv-NET and corrected for under-detection. Influenza deaths were calculated using a ratio of deaths to hospitalizations. We estimated that influenza-related hospitalizations were under-detected during 2010-11 by a factor of 2.1 (95% CI 1.7-2.9) for age < 18 years, 3.1 (2.4-4.5) for ages 18-64 years, and 5.2 (95% CI 3.8-8.3) for age 65+. Results were similar in 2011-12. Extrapolated estimates for 3 seasons from 2010-2013 included: 114,192-624,435 hospitalizations, 18,491-95,390 ICU admissions, and 4,915-27,174 deaths per year; 54-70% of hospitalizations and 71-85% of deaths occurred among adults aged 65+. Influenza causes a substantial disease burden in the U. S. that varies by age and season. Periodic estimation of multipliers across multiple sites and age groups improves our understanding of influenza detection in sentinel surveillance systems. Adjusting surveillance data using a multiplier method is a relatively simple means to estimate the impact of influenza and the subsequent value of interventions to prevent influenza. C1 [Reed, Carrie; Chaves, Sandra S.; Finelli, Lyn] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA. [Kirley, Pam Daily; Emerson, Ruth] Calif Emerging Infect Program, Oakland, CA USA. [Aragon, Deborah] Colorado Dept Publ Hlth & Environm, Colorado Emerging Infect Program, Denver, CO USA. [Hancock, Emily B.; Butler, Lisa; Baumbach, Joan] New Mexico Emerging Infect Program, Santa Fe, NM USA. [Hollick, Gary; Bennett, Nancy M.] Univ Rochester, Sch Med & Dent, New York Emerging Infect Program, Rochester, NY USA. [Laidler, Matthew R.; Thomas, Ann] Oregon Publ Hlth Div, Portland, OR USA. [Meltzer, Martin I.] Ctr Dis Control & Prevent, Div Preparedness & Emerging Infect, Atlanta, GA USA. RP Reed, C (reprint author), Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA. EM creed1@cdc.gov NR 24 TC 24 Z9 24 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 4 PY 2015 VL 10 IS 3 AR e0118369 DI 10.1371/journal.pone.0118369 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CC9JM UT WOS:000350685900032 PM 25738736 ER PT J AU Saha, S Brock, JW Vaidyanathan, A Easterling, DR Luber, G AF Saha, Shubhayu Brock, John W. Vaidyanathan, Ambarish Easterling, David R. Luber, George TI Spatial variation in hyperthermia emergency department visits among those with employer-based insurance in the United States - a case-crossover analysis SO ENVIRONMENTAL HEALTH LA English DT Article DE Case-crossover; Extreme heat; Hyperthermia; Meta-analysis; Spatial risk ID HEAT-RELATED MORTALITY; NEW-YORK-STATE; HIGH-TEMPERATURES; CLIMATE-CHANGE; AMBIENT-TEMPERATURE; HOSPITAL ADMISSIONS; WAVE; DISEASES; ILLNESS; POPULATION AB Background: Predictions of intense heat waves across the United States will lead to localized health impacts, most of which are preventable. There is a need to better understand the spatial variation in the morbidity impacts associated with extreme heat across the country to prevent such adverse health outcomes. Methods: Hyperthermia-related emergency department (ED) visits were obtained from the Truven Health MarketScan (R) Research dataset for 2000-2010. Three measures of daily ambient heat were constructed using meteorological observations from the National Climatic Data Center (maximum temperature, heat index) and the Spatial Synoptic Classification. Using a time-stratified case crossover approach, odds ratio of hyperthermia-related ED visit were estimated for the three different heat measures. Random effects meta-analysis was used to combine the odds ratios for 94 Metropolitan Statistical Areas (MSA) to examine the spatial variation by eight latitude categories and nine U.S. climate regions. Results: Examination of lags for all three temperature measures showed that the odds ratio of ED visit was statistically significant and highest on the day of the ED visit. For heat waves lasting two or more days, additional statistically significant association was observed when heat index and synoptic classification was used as the temperature measure. These results were insensitive to the inclusion of air pollution measures. On average, the maximum temperature on the day of an ED visit was 93.4 degrees F in 'South' and 81.9 degrees F in the 'Northwest' climatic regions of United States. The meta-analysis showed higher odds ratios of hyperthermia ED visit in the central and the northern parts of the country compared to the south and southwest. Conclusion: The results showed spatial variation in average temperature on days of ED visit and odds ratio for hyperthermia ED visits associated with extreme heat across United States. This suggests that heat response plans need to be customized for different regions and the potential role of hyperthermia ED visits in syndromic surveillance for extreme heat. C1 [Saha, Shubhayu; Luber, George] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Environm Hazards & Hlth Effects, Climate & Hlth Program, Atlanta, GA 30341 USA. [Brock, John W.] Warren Wilson Coll, Dept Chem, Asheville, NC 28815 USA. [Brock, John W.] Warren Wilson Coll, Dept Environm Studies, Asheville, NC 28815 USA. [Vaidyanathan, Ambarish] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Environm Hazards & Hlth Effects, Environm Hlth Tracking Branch, Atlanta, GA 30341 USA. [Easterling, David R.] Natl Climat Ctr, Asheville, NC 28801 USA. RP Saha, S (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Environm Hazards & Hlth Effects, Climate & Hlth Program, Atlanta, GA 30341 USA. EM ssaha@cdc.gov FU Climate and Health Program within the Centers for Disease Control and Prevention FX The authors would like to thank Dr. Dana Flanders, Ethel Taylor, Dr. Fuyuen Yip at Centers for Disease Control for helpful comments on the paper. John W. Brock acknowledges funding from the Climate and Health Program within the Centers for Disease Control and Prevention and sabbatical release from Warren Wilson College for research. We thank Dr. Jay Livermore at National Oceanic and Atmospheric Administration's National Climatic Data Center (NCDC) for consultation, office space, use of computer time and access to archived weather data. We thank Anthony Arguez for assistance with the U.S. climate normals. We also thank Steven Anthony from STG Inc. for technical support at NCDC. NR 42 TC 5 Z9 5 U1 1 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1476-069X J9 ENVIRON HEALTH-GLOB JI Environ. Health PD MAR 4 PY 2015 VL 14 AR 20 DI 10.1186/s12940-015-0005-z PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA CD3IR UT WOS:000350972200001 PM 25888865 ER PT J AU Best, AL Spencer, M Hall, IJ Friedman, DB Billings, D AF Best, Alicia L. Spencer, Mindi Hall, Ingrid J. Friedman, Daniela B. Billings, Deborah TI Developing Spiritually Framed Breast Cancer Screening Messages in Consultation With African American Women SO HEALTH COMMUNICATION LA English DT Article ID HEALTH COMMUNICATION; RACIAL-DIFFERENCES; MAMMOGRAPHY USE; UNITED-STATES; CULTURE; INFORMATION; LOCUS AB Despite efforts to increase breast cancer screening (BCS) among African American women, disparities in breast cancer mortality persist. Culturally framed health communication may provide a useful strategy to address this issue. Spirituality not only represents an integral aspect of African American culture, but it has also been identified as a potential barrier to BCS among this population. Rather than continuing to focus on spirituality as a barrier, there is an opportunity to develop promotional messages that tap into the protective properties of spirituality among this population. The goals of this study were to engage a group of African American women to identify important spiritual elements to be included in health communication materials, and to subsequently develop a spiritually framed BCS message in response to their feedback. Three nominal group sessions were conducted with 15 African American women. Results revealed three important spiritual elements that can be incorporated into BCS health messages: (a) the body as a temple; (b) going to the doctor does not make you faithless; and (c) God did not give us the spirit of fear. These elements were used to draft a spiritually framed BCS message. Next, 20 face-to-face semistructured interviews were conducted to help finalize the spiritually framed BCS message for use in a future study on culturally framed health communication. C1 [Best, Alicia L.] HEALing Community Ctr, Dept Res & Community Hlth, Atlanta, GA 30311 USA. [Spencer, Mindi; Friedman, Daniela B.; Billings, Deborah] Univ S Carolina, Arnold Sch Publ Hlth, Columbia, SC 29208 USA. [Hall, Ingrid J.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA USA. RP Best, AL (reprint author), HEALing Community Ctr, Dept Res & Community Hlth, 2600 Martin Luther King,Jr Dr SW,Suite 100, Atlanta, GA 30311 USA. EM alicialbest@gmail.com NR 48 TC 3 Z9 3 U1 4 U2 16 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1041-0236 EI 1532-7027 J9 HEALTH COMMUN JI Health Commun. PD MAR 4 PY 2015 VL 30 IS 3 BP 290 EP 300 DI 10.1080/10410236.2013.845063 PG 11 WC Communication; Health Policy & Services SC Communication; Health Care Sciences & Services GA AW9NZ UT WOS:000346585600009 PM 24837069 ER PT J AU Mdodo, R Frazier, EL Dube, SR Mattson, CL Sutton, MY Brooks, JT Skarbinski, J AF Mdodo, Rennatus Frazier, Emma L. Dube, Shanta R. Mattson, Christine L. Sutton, Madeline Y. Brooks, John T. Skarbinski, Jacek TI Cigarette Smoking Prevalence Among Adults With HIV Compared With the General Adult Population in the United States SO ANNALS OF INTERNAL MEDICINE LA English DT Article ID INFECTED PERSONS; MENTAL-ILLNESS; RISK-FACTORS; CESSATION; SMOKERS; AIDS; SURVEILLANCE; METAANALYSIS; INDIVIDUALS; TOBACCO AB Background: The negative health effects of cigarette smoking and HIV infection are synergistic. Objective: To compare the prevalence of current cigarette smoking and smoking cessation between adults with HIV receiving medical care and adults in the general population. Design: Nationally representative cross-sectional surveys. Setting: United States. Patients: 4217 adults with HIV who participated in the Medical Monitoring Project and 27 731 U.S. adults who participated in the National Health Interview Survey in 2009. Measurements: The main exposure was cigarette smoking. The outcome measures were weighted prevalence of cigarette smoking and quit ratio (ratio of former smokers to the sum of former and current smokers). Results: Of the estimated 419 945 adults with HIV receiving medical care, 42.4% (95% CI, 39.7% to 45.1%) were current cigarette smokers, 20.3% (CI, 18.6% to 22.1%) were former smokers, and 37.3% (CI, 34.9% to 39.6%) had never smoked. Compared with the U.S. adult population, in which an estimated 20.6% of adults smoked cigarettes in 2009, adults with HIV were nearly twice as likely to smoke (adjusted prevalence difference, 17.0 percentage points [CI, 14.0 to 20.1 percentage points]) but were less likely to quit smoking (quit ratio, 32.4% vs. 51.7%). Among adults with HIV, factors independently associated with greater smoking prevalence were older age, non-Hispanic white or non-Hispanic black race, lower educational level, poverty, homelessness, incarceration, substance use, binge alcohol use, depression, and not achieving a suppressed HIV viral load. Limitation: Cross-sectional design with some generalizability limitations. Conclusion: Adults with HIV were more likely to smoke and less likely to quit smoking than the general adult population. Tobacco screening and cessation strategies are important considerations as part of routine HIV care. C1 Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30329 USA. Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Off Smoking & Hlth, Atlanta, GA 30329 USA. Georgia State Univ, Sch Publ Hlth, Atlanta, GA 30303 USA. RP Sutton, MY (reprint author), Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div HIV AIDS Prevent, Off Infect Dis, 1600 Clifton Rd NE,Mail Stop E-45, Atlanta, GA 30329 USA. EM msutton@cdc.gov FU Centers for Disease Control and Prevention FX Centers for Disease Control and Prevention. NR 62 TC 53 Z9 53 U1 2 U2 7 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA SN 0003-4819 EI 1539-3704 J9 ANN INTERN MED JI Ann. Intern. Med. PD MAR 3 PY 2015 VL 162 IS 5 BP 335 EP U131 DI 10.7326/M14-0954 PG 14 WC Medicine, General & Internal SC General & Internal Medicine GA CC3HT UT WOS:000350238300002 PM 25732274 ER PT J AU Reber, AJ Kim, JH Biber, R Talbot, HK Coleman, LA Chirkova, T Gross, FL Steward-Clark, E Cao, WP Jefferson, S Veguilla, V Gillis, E Meece, J Bai, YH Tatum, H Hancock, K Stevens, J Spencer, S Chen, JF Gargiullo, P Braun, E Griffin, MR Sundaram, M Belongia, EA Shay, DK Katz, JM Sambhara, S AF Reber, Adrian J. Kim, Jin Hyang Biber, Renata Talbot, H. Keipp Coleman, Laura A. Chirkova, Tatiana Gross, F. Liaini Steward-Clark, Evelene Cao, Weiping Jefferson, Stacie Veguilla, Vic Gillis, Eric Meece, Jennifer Bai, Yaohui Tatum, Heather Hancock, Kathy Stevens, James Spencer, Sarah Chen, Jufu Gargiullo, Paul Braun, Elise Griffin, Marie R. Sundaram, Maria Belongia, Edward A. Shay, David K. Katz, Jacqueline M. Sambhara, Suryaprakash TI Preexisting Immunity, More Than Aging, Influences Influenza Vaccine Responses SO OPEN FORUM INFECTIOUS DISEASES LA English DT Article DE aging; immune response; influenza; older adults; vaccine ID RESPIRATORY SYNCYTIAL VIRUS; UNITED-STATES; CELL RESPONSES; OLDER-ADULTS; B-CELLS; AGE; ANTIBODY; PROTECTION; DIVERSITY; INFECTION AB Background. Influenza disproportionately impacts older adults while current vaccines have reduced effectiveness in the older population. Methods. We conducted a comprehensive evaluation of cellular and humoral immune responses of adults aged 50 years and older to the 2008-2009 seasonal trivalent inactivated influenza vaccine and assessed factors influencing vaccine response. Results. Vaccination increased hemagglutination inhibition and neutralizing antibody; however, 66.3% of subjects did not reach hemagglutination inhibition titers >= 40 for H1N1, compared with 22.5% for H3N2. Increasing age had a minor negative impact on antibody responses, whereas prevaccination titers were the best predictors of post-vaccination antibody levels. Preexisting memory B cells declined with age, especially for H3N2. However, older adults still demonstrated a significant increase in antigen-specific IgG(+) and IgA(+) memory B cells postvaccination. Despite reduced frequency of preexisting memory B cells associated with advanced age, fold-rise in memory B cell frequency in subjects 60+ was comparable to subjects age 50-59. Conclusions. Older adults mounted statistically significant humoral and cell-mediated immune responses, but many failed to reach hemagglutination inhibition titers >= 40, especially for H1N1. Although age had a modest negative effect on vaccine responses, prevaccination titers were the best predictor of postvaccination antibody levels, irrespective of age. C1 [Reber, Adrian J.; Kim, Jin Hyang; Biber, Renata; Chirkova, Tatiana; Gross, F. Liaini; Steward-Clark, Evelene; Cao, Weiping; Jefferson, Stacie; Veguilla, Vic; Gillis, Eric; Bai, Yaohui; Tatum, Heather; Hancock, Kathy; Stevens, James; Spencer, Sarah; Chen, Jufu; Gargiullo, Paul; Braun, Elise; Shay, David K.; Katz, Jacqueline M.; Sambhara, Suryaprakash] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Talbot, H. Keipp; Griffin, Marie R.] Vanderbilt Univ, Med Ctr, Nashville, TN USA. [Griffin, Marie R.] VA TN Valley Healthcare Syst, Mid South Geriatr Res Educ & Clin Ctr, Nashville, TN USA. RP Sambhara, S (reprint author), Ctr Dis Control & Prevent, Influenza Div, Immunol & Pathogenesis Branch, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM ssambhara@cdc.gov NR 37 TC 6 Z9 6 U1 1 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 2328-8957 J9 OPEN FORUM INFECT DI JI Open Forum Infect. Dis. PD SPR PY 2015 VL 2 IS 2 DI 10.1093/ofid/ofv052 PG 12 WC Infectious Diseases SC Infectious Diseases GA CX6BM UT WOS:000365786200042 ER PT J AU Schwitters, A Lederer, P Zilversmit, L Gudo, PS Ramiro, I Cumba, L Mahagaja, E Jobarteh, K AF Schwitters, Amee Lederer, Philip Zilversmit, Leah Gudo, Paula Samo Ramiro, Isaias Cumba, Luisa Mahagaja, Epifanio Jobarteh, Kebba TI Barriers to Health Care in Rural Mozambique: A Rapid Ethnographic Assessment of Planned Mobile Health Clinics for ART SO GLOBAL HEALTH-SCIENCE AND PRACTICE LA English DT Article ID ANTIRETROVIRAL THERAPY; ZAMBEZIA PROVINCE; TRADITIONAL HEALERS; SOUTH-AFRICA; SERVICES; STRATEGIES; ATTITUDES; UGANDA; AIDS AB Background: In Mozambique, 1.6 million people are living with HIV, and over 60% of the population lives in rural areas lacking access to health services. Mobile health clinics, implemented in 2013 in 2 provinces, are beginning to offer antiretroviral therapy (ART) and basic primary care services. Prior to introduction of the mobile health clinics in the communities, we performed a rapid ethnographic assessment to understand barriers to accessing HIV care and treatment services and acceptability and potential use of the mobile health clinics as an alternative means of service delivery. Methods: We conducted assessments in Gaza province in January 2013 and in Zambezia Province in April-May 2013 in districts where mobile health clinic implementation was planned. Community leaders served as key informants, and chain-referral sampling was used to recruit participants. Interviews were conducted with community leaders, health care providers, traditional healers, national health system patients, and traditional healer patients. Interviewees were asked about barriers to health services and about mobile health clinic acceptance. Results: In-depth interviews were conducted with 117 participants (Gaza province, n=57; Zambezia Province, n=60). Barriers to accessing health services included transportation and distance-related issues (reliability, cost, and travel time). Participants reported concurrent use of traditional and national health systems. The decision to use a particular health system depended on illness type, service distance, and lack of confidence in the national health system. Overall, participants were receptive to using mobile health clinics for their health care and ability to increase access to ART. Hesitations concerning mobile health clinics included potentially long wait times due to high patient loads. Participants emphasized the importance of regular and published visit schedules and inclusion of community members in planning mobile health clinic services. Conclusion: Mobile health clinics can address many barriers to uptake of HIV services, particularly related to transportation issues. Involvement of community leaders, providers, traditional healers, and patients, as well as regularly scheduled mobile clinic visits, are critical to successful service delivery implementation in rural areas. C1 [Schwitters, Amee; Lederer, Philip] Ctr Dis Control & Prevent, Ctr Global Hlth, Atlanta, GA 30333 USA. [Schwitters, Amee; Lederer, Philip] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. [Zilversmit, Leah; Gudo, Paula Samo; Jobarteh, Kebba] Ctr Dis Control & Prevent, Maputo, Mozambique. [Zilversmit, Leah] Assoc Sch & Programs Publ Hlth, Washington, DC USA. [Ramiro, Isaias] Mozamb Minist Hlth, Xai Xai, Mozambique. [Cumba, Luisa; Mahagaja, Epifanio] Minist Hlth, Zambezia, Mozambique. RP Schwitters, A (reprint author), Ctr Dis Control & Prevent, Ctr Global Hlth, Atlanta, GA 30333 USA. EM efn6@cdc.gov FU PEPFAR NR 26 TC 6 Z9 6 U1 5 U2 7 PU US AGENCY INT DEVELOPMENT-USAID PI BALTIMORE PA US AGENCY INT DEVELOPMENT-USAID, BALTIMORE, MD 00000 USA SN 2169-575X J9 GLOB HEALTH JI Glob. Health PD MAR PY 2015 VL 3 IS 1 BP 109 EP 116 DI 10.9745/GHSP-D-14-00145 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CO2SO UT WOS:000359007100010 PM 25745124 ER PT J AU Neri, EM Stringer, KJ Spadaro, AJ Ballman, MR Grunbaum, JA AF Neri, Elizabeth M. Stringer, Kate J. Spadaro, Antonia J. Ballman, Marie R. Grunbaum, Jo Anne TI Common Pathways Toward Informing Policy and Environmental Strategies to Promote Health: A Study of CDC's Prevention Research Centers SO HEALTH PROMOTION PRACTICE LA English DT Article DE public health laws/policies; chronic disease; community-based participatory research ID PUBLIC-HEALTH; PARTICIPATORY RESEARCH; DISPARITIES; SCIENCE AB This study examined the roles academic researchers can play to inform policy and environmental strategies that promote health and prevent disease. Prevention Research Centers (PRCs) engage in academic-community partnerships to conduct applied public health research. Interviews were used to collect data on the roles played by 32 PRCs to inform policy and environmental strategies that were implemented between September 2009 and September 2010. Descriptive statistics were calculated in SAS 9.2. A difference in roles played was observed depending on whether strategies were policy or environmental. Of the policy initiatives, the most common roles were education, research, and partnership. In contrast, the most prevalent roles the PRCs played in environmental approaches were research and providing health promotion resources. Academic research centers play various roles to help inform policy and environmental strategies. C1 [Neri, Elizabeth M.; Spadaro, Antonia J.; Ballman, Marie R.; Grunbaum, Jo Anne] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Stringer, Kate J.] Total Therapeut Management, Kennesaw, GA USA. RP Neri, EM (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway MS F 78, Atlanta, GA 30341 USA. EM ioi7@cdc.gov NR 28 TC 1 Z9 1 U1 1 U2 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1524-8399 EI 1552-6372 J9 HEALTH PROMOT PRACT JI Health Promot. Pract. PD MAR PY 2015 VL 16 IS 2 BP 218 EP 226 DI 10.1177/1524839914553593 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CL9LK UT WOS:000357299900010 PM 25301898 ER PT J AU Jewett, A Garg, A Meyer, K Wagner, LD Krauskopf, K Brown, KA Pan, JJ Massoud, O Smith, BD Rein, DB AF Jewett, Amy Garg, Arika Meyer, Katherine Wagner, Laura Danielle Krauskopf, Katherine Brown, Kimberly A. Pan, Jen-Jung Massoud, Omar Smith, Bryce D. Rein, David B. TI Hepatitis C Virus Testing Perspectives Among Primary Care Physicians in Four Large Primary Care Settings SO HEALTH PROMOTION PRACTICE LA English DT Article DE delivery of health care; guidelines; hepatitis; screening ID UNITED-STATES; IDENTIFICATION; MANAGEMENT; INFECTION; PREVALENCE; DIAGNOSIS; MORTALITY; CLINICS; MODEL AB Background. In 1998, the Centers for Disease Control and Prevention (CDC) published Recommendations for Prevention and Control of Hepatitis C Virus (HCV) Infection and HCV-Related Chronic Disease, recommending HCV testing for populations most likely to be infected with HCV. However, the implementation of risk-based screening has not been widely adopted in health care settings, and 45% to 85% of infected U.S. adults remain unidentified. Objectives. To develop a better understanding of why CDC's 1998 recommendations have had limited success in identifying persons with HCV infection and provide information about how CDC's 2012 Recommendations for the Identification of Chronic Hepatitis C Virus Infection Among Persons Born During 1945-1965 may be implemented more effectively. Design. Qualitative data were collected and analyzed from a multidisciplinary team as part of the Birth Cohort Evaluation to Advance Screening and Testing for Hepatitis C project. Respondents. Nineteen providers were asked open-ended questions to identify current perspectives, practices, facilitators, and barriers to HCV screening and testing. Providers were affiliated with Henry Ford Hospital, Mount Sinai Hospital, the University of Alabama, and the University of Texas Health Science Center. Results. Respondents reported the complexity of the 1998 recommendations, and numerous indicated risk factors were major barriers to effective implementation. Other hindrances to hepatitis C testing included physician discomfort in asking questions about socially undesirable behaviors and physician uncertainty about patient insurance coverage. Conclusion. Implementation of the CDC's 2012 recommendations could be more successful than the 1998 recommendations due to their relative simplicity; however, effective strategies need to be used for dissemination and implementation for full success. C1 [Jewett, Amy] Oak Ridge Inst Sci & Educ, Clinton, TN USA. [Garg, Arika; Meyer, Katherine; Rein, David B.] Univ Chicago, NORC, Chicago, IL 60637 USA. [Wagner, Laura Danielle] RTI Int, Waltham, MA USA. [Krauskopf, Katherine] Icahn Sch Med Mt Sinai, New York, NY 10029 USA. [Brown, Kimberly A.] Henry Ford Hosp, Detroit, MI 48202 USA. [Pan, Jen-Jung] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA. [Massoud, Omar] Univ Alabama Birmingham, Birmingham, AL USA. [Smith, Bryce D.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Smith, BD (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, 1600 Clifton Rd,MS G 37, Atlanta, GA 30333 USA. EM bsmith6@cdc.gov NR 26 TC 6 Z9 6 U1 0 U2 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1524-8399 EI 1552-6372 J9 HEALTH PROMOT PRACT JI Health Promot. Pract. PD MAR PY 2015 VL 16 IS 2 BP 256 EP 263 DI 10.1177/1524839914532291 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CL9LK UT WOS:000357299900014 PM 24776636 ER PT J AU Balcazar, H Fernandez-Gaxiola, AC Perez-Lizaur, AB Peyron, RA Ayala, C AF Balcazar, Hector Cecilia Fernandez-Gaxiola, Ana Bertha Perez-Lizaur, Ana Adriana Peyron, Rosa Ayala, Carma TI Improving Heart Healthy Lifestyles Among Participants in a Salud Para Su Corazon Promotores Model: The Mexican Pilot Study, 2009-2012 SO PREVENTING CHRONIC DISEASE LA English DT Article ID CARDIOVASCULAR-DISEASE RISK; COMMUNITY INTERVENTION; OUTREACH MODEL; PREVENTION; BURDEN AB Introduction In Mexico, cardiovascular disease and its risk factors are growing problems and major public health concerns. The objective of this study was to implement cardiovascular health promotion and disease prevention activities of the Salud para su Corazon model in a high-risk, impoverished, urban community in Mexico City. Methods We used a pretest-posttest (baseline to 12-week follow-up) design without a control group. Material from Salud para su Corazon was validated and delivered by promotores (community health workers) to community members from 6 geographic areas. Two validated, self-administered questionnaires that assessed participants' knowledge and behaviors relating to heart health were administered. We used t tests and.2 tests to evaluate pretest and posttest differences, by age group (<= 60 and >60 years), for participants' 3 heart-healthy habits, 3 types of physical activity, performance skills, and anthropometric and clinical measurements. Results A total of 452 (82%) adult participants completed the program. Heart-healthy habits from pretest to posttest varied by age group. "Taking action" to modify lifestyle behaviors increased among adults aged 60 or younger from 31.5% to 63.0% (P < .001) and among adults older than 60 from 30.0% to 45.0% (P < .001). Positive responses for cholesterol and fat consumption reduction were seen among participants 60 or younger (P = .03). Among those older than 60, salt reduction and weight control increased (P = .008). Mean blood glucose concentration among adults older than 60 decreased postintervention (P = .03). Conclusion Significant improvements in some heart-healthy habits were seen among adult participants. The model has potential to improve heart-healthy habits and facilitate behavioral change among highrisk adults. C1 [Balcazar, Hector] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, El Paso, TX 79902 USA. [Cecilia Fernandez-Gaxiola, Ana; Bertha Perez-Lizaur, Ana; Adriana Peyron, Rosa] Univ Iberoamer Ciudad Mexico, Mexico City, DF, Mexico. [Ayala, Carma] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Balcazar, H (reprint author), Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, El Paso Reg Campus,1101 N Campbell,CH 400, El Paso, TX 79902 USA. EM Hector.G.Balcazar@uth.tmc.edu FU Sistema Universitario Jesuita; Fundacion SERTULL AC; Department of Health of the Universidad Iberoamericana Mexico City FX We thank all the promotores and partners of the Santa Fe community for their work on and support for this project. The project was financed by the Sistema Universitario Jesuita, Fundacion SERTULL AC, and the Department of Health of the Universidad Iberoamericana Mexico City. NR 30 TC 1 Z9 1 U1 3 U2 7 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD MAR PY 2015 VL 12 AR E34 DI 10.5888/pcd12.140292 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CL0YM UT WOS:000356669000007 PM 25764140 ER PT J AU Jayakumar, V Kim, J Zechmann, E AF Jayakumar, Vignesh Kim, Jay Zechmann, Edward TI Identification of noise sources and design of noise reduction measures for a pneumatic nail gun SO NOISE CONTROL ENGINEERING JOURNAL LA English DT Article ID 3-DIMENSIONAL CAVITIES; FORMULATION AB An experimental-analytical procedure was implemented to reduce the operating noise level of a nail gun, a commonly found power tool in a construction site. The procedure is comprised of preliminary measurements, identification and ranking of major noise sources and application of noise controls. Preliminary measurements show that the impact noise transmitted through the structure and the exhaust related noise were found to be the first and second major contributors. Applying a noise absorbing foam on the outside of the nail gun body was found to be an effective noise reduction technique. One-and two-volume small mufflers were designed and applied to the exhaust side of the nail gun which reduced not only the exhaust noise but also the impact noise. It was shown that the overall noise level could be reduced by as much as 3.5 dB, suggesting that significant noise reduction is possible in construction power tools without any significant increase of the cost. (C) 2015 Institute of Noise Control Engineering. C1 [Jayakumar, Vignesh; Kim, Jay] Univ Cincinnati, Dept Mech & Mat Engn, Cincinnati, OH 45221 USA. [Zechmann, Edward] NIOSH, Cincinnati, OH 45226 USA. RP Kim, J (reprint author), Univ Cincinnati, Dept Mech & Mat Engn, Cincinnati, OH 45221 USA. EM jayakuvh@mail.uc.edu; kimj@ucmail.uc.edu; cri6@cdc.gov FU INCE/USA; INCE Foundation FX We thank SENCO for providing a FramePro 601 and safety instruction and technical assistance in developing the noise controls. We are grateful to Sage Technologies of Walled Lake, MI for acquiring and analyzing data with the AC Pro Acoustic Camera. We would also like to thank INCE/USA and the INCE Foundation for providing the $500.00 student project grant that enabled a student project study presented in Noise-Con 2013 that formed the basis of this paper. We would also like to thank those who participated in the student project: Andrew Hubbard, George Schneider and Stephen Louie. NR 18 TC 1 Z9 1 U1 0 U2 4 PU INST NOISE CONTROL ENGINEERING PI AMES PA IOWA STATE UNIV, COLLEGE ENGINEERING, 212 MARSTON HALL, AMES, IA 50011-2152 USA SN 0736-2501 J9 NOISE CONTROL ENG J JI Noise Control Eng. J. PD MAR-APR PY 2015 VL 63 IS 2 BP 159 EP 168 PG 10 WC Acoustics; Engineering, Multidisciplinary SC Acoustics; Engineering GA CK7SL UT WOS:000356432500005 PM 26366038 ER PT J AU Vuylsteke, B Semde, G Auld, AF Sabatier, J Kouakou, J Ettiegne-Traore, V Buve, A Laga, M AF Vuylsteke, Bea Semde, Gisele Auld, Andrew F. Sabatier, Jennifer Kouakou, Joseph Ettiegne-Traore, Virginie Buve, Anne Laga, Marie TI Retention and Risk Factors for Loss to Follow-up of Female and Male Sex Workers on Antiretroviral Treatment in Ivory Coast: A Retrospective Cohort Analysis SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE ART; sex workers; retention on ART; loss to follow-up ID HIV-1-INFECTED PATIENTS; MULTIPLE IMPUTATION; INCOME COUNTRIES; MISSING VALUES; COTE-DIVOIRE; SOUTH-AFRICA; THERAPY; HIV; OUTCOMES; PROGRAMS AB Background: Antiretroviral therapy (ART) for HIV-infected sex workers is an important HIV prevention strategy. However, sex workers may have additional challenges for retention in ART care. The objectives of this study were to assess retention of sex workers on ART in a routine setting in Ivory Coast and identify risk factors for loss to follow-up (LTFU). Methods: The design was a retrospective cohort study. An analysis of clinic files was conducted in 2 sites providing ART services to sex workers in Ivory Coast. Demographic, behavior, and clinical data of female and male sex workers on ART were abstracted onto a standardized anonymous data collection form. Data collection took place between May 11 and 28, 2010. Results: A total of 376 female and 38 male sex workers were included in the analysis. The retention probability was 75% at 6 months, 68% at 12 months, 55% at 24 months, and 47% at 36 months. Attrition was mainly because of LTFU. Factors significantly associated with LTFU in bivariate analysis were lower schooling level, later calendar year of starting ART, and not receiving initial adherence counseling. Later year of starting ART and not receiving adherence counseling at ART initiation remained significantly associated with LTFU in a multivariate Cox regression model. Conclusions: To improve the retention of sex workers on ART, there is a need for more in-depth investigation of the role of pre-ART counseling and the increasing rates of LTFU with each calendar year. C1 [Vuylsteke, Bea; Buve, Anne; Laga, Marie] Inst Trop Med, B-2000 Antwerp, Belgium. [Semde, Gisele] Family Hlth Int 360, Abidjan, Cote Ivoire. [Auld, Andrew F.; Sabatier, Jennifer] Ctr Dis Control & Prevent, Atlanta, GA USA. [Kouakou, Joseph] Elisabeth Glazer Paediat AIDS Fdn, Abidjan, Cote Ivoire. RP Vuylsteke, B (reprint author), Inst Trop Med, Natl Str 155, B-2000 Antwerp, Belgium. EM bvuylsteke@itg.be FU President's Emergency Plan for AIDS Relief (PEPFAR) through the US Centers for Disease Control and Prevention (CDC); Belgian Directorate-General for Development Cooperation (DGD) through a Framework Agreement with the Institute of Tropical Medicine FX Supported by the President's Emergency Plan for AIDS Relief (PEPFAR) through the US Centers for Disease Control and Prevention (CDC) and the Belgian Directorate-General for Development Cooperation (DGD) through a Framework Agreement with the Institute of Tropical Medicine. NR 32 TC 2 Z9 2 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD MAR 1 PY 2015 VL 68 SU 2 BP S99 EP S106 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CH6CJ UT WOS:000354123100005 PM 25723997 ER PT J AU Piercy, KL Dorn, JM Fulton, JE Janz, KF Lee, SM McKinnon, RA Pate, RR Pfeiffer, KA Young, DR Troiano, RP Lavizzo-Mourey, R AF Piercy, Katrina L. Dorn, Joan M. Fulton, Janet E. Janz, Kathleen F. Lee, Sarah M. McKinnon, Robin A. Pate, Russell R. Pfeiffer, Karin A. Young, Deborah Rohm Troiano, Richard P. Lavizzo-Mourey, Risa TI Opportunities for Public Health to Increase Physical Activity Among Youths SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID CHILD-CARE; INTERVENTIONS; ENVIRONMENT; PRESCHOOL; PROGRAM AB Despite the well-known benefits of youths engaging in 60 or more minutes of daily physical activity, physical inactivity remains a significant public health concern. The 2008 Physical Activity Guidelines for Americans (PAG) provides recommendations on the amount of physical activity needed for overall health; the PAG Midcourse Report (2013) describes effective strategies to help youths meet these recommendations. Public health professionals can be dynamic change agents where youths live, learn, and play by changing environments and policies to empower youths to develop regular physical activity habits to maintain throughout life. We have summarized key findings from the PAG Midcourse Report and outlined actions that public health professionals can take to ensure that all youths regularly engage in health-enhancing physical activity. C1 [Piercy, Katrina L.] US Dept HHS, Off Dis Prevent & Hlth Promot, Rockville, MD USA. [Dorn, Joan M.; Fulton, Janet E.; Lee, Sarah M.] US Dept HHS, Ctr Dis Control & Prevent, Atlanta, GA USA. [Janz, Kathleen F.] Univ Iowa, Dept Hlth & Human Physiol, Iowa City, IA USA. [McKinnon, Robin A.; Troiano, Richard P.] US Dept HHS, NIH, Bethesda, MD USA. [Pate, Russell R.] Univ S Carolina, Dept Exercise Sci, Columbia, SC 29208 USA. [Pfeiffer, Karin A.] Michigan State Univ, Dept Kinesiol, E Lansing, MI 48824 USA. [Young, Deborah Rohm] Kaiser Permanente So Calif, Dept Res & Evaluat, Pasadena, CA 91101 USA. [Lavizzo-Mourey, Risa] Robert Wood Johnson Fdn, Princeton, NJ 08540 USA. RP Piercy, KL (reprint author), 1101Wootton Pkwy,Suite LL100, Rockville, MD 20852 USA. EM Katrina.Piercy@hhs.gov OI Troiano, Richard/0000-0002-6807-989X NR 32 TC 7 Z9 7 U1 0 U2 5 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD MAR PY 2015 VL 105 IS 3 BP 421 EP 426 DI 10.2105/AJPH.2014.302325 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CH5DP UT WOS:000354055100019 PM 25602864 ER PT J AU Auerbach, J AF Auerbach, John TI Creating Incentives to Move Upstream: Developing a Diversified Portfolio of Population Health Measures Within Payment and Health Care Reform SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material AB I examined the feasibility of developing a balanced portfolio of population health measures that would be useful within the current deliberations about health care and payment reform. My commentary acknowledges that an obstacle to the selection of population health metrics is the differing definitions of population health. Rather than choosing between these definitions, I identified five categories of indicators, ranging from traditional clinical care prevention interventions to those that measure investment in community-level nonclinical services, that in various combinations might yield the most promising results. I offer concrete examples of markers in each of the categories and show that there is a growing number of individuals eager to receive concrete recommendations and implement population health pilot programs. C1 [Auerbach, John] Northeastern Univ, Inst Urban Hlth Res & Practice, Bouve Coll Hlth Sci, Boston, MA 02115 USA. RP Auerbach, J (reprint author), Ctr Dis Control & Prevent, Directors Off, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM Auerbach.john@gmail.com NR 19 TC 3 Z9 3 U1 0 U2 1 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD MAR PY 2015 VL 105 IS 3 BP 427 EP 431 DI 10.2105/AJPH.2014.302371 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CH5DP UT WOS:000354055100020 PM 25602896 ER PT J AU Franklin, G Sabel, J Jones, CM Mai, J Baumgartner, C Banta-Green, CJ Neven, D Tauben, DJ AF Franklin, Gary Sabel, Jennifer Jones, Christopher M. Mai, Jaymie Baumgartner, Chris Banta-Green, Caleb J. Neven, Darin Tauben, David J. TI A Comprehensive Approach to Address the Prescription Opioid Epidemic in Washington State: Milestones and Lessons Learned SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID CHRONIC NONCANCER PAIN; WORKERS-COMPENSATION; NONMALIGNANT PAIN; DOSING GUIDELINE; UNITED-STATES; OVERDOSE; DEATHS; MORTALITY; IMPLEMENTATION; ANALGESICS AB An epidemic of morbidity and mortality has swept across the United States related to the use of prescription opioids for chronic noncancer pain. More than 100 000 people have died from unintentional overdose, making this one of the worst manmade epidemics in history. Much of health care delivery in the United States is regulated at the state level; therefore, both the cause and much of the cure for the opioid epidemic will come from state action. We detail the strong collaborations across executive health care agencies, and between those public agencies and practicing leaders in the pain field that have led to a substantial reversal of the epidemic in Washington State. C1 [Franklin, Gary] Univ Washington, Sch Publ Hlth, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA. [Sabel, Jennifer; Baumgartner, Chris] Washington State Dept Hlth, Olympia, WA USA. [Jones, Christopher M.] Natl Ctr Injury Prevent & Control, Ctr Dis Control & Prevent, Atlanta, GA USA. [Mai, Jaymie] Washington State Dept Labor & Ind, Olympia, WA 98504 USA. [Banta-Green, Caleb J.] Univ Washington, Alcohol & Drug Abuse Inst, Seattle, WA 98195 USA. [Neven, Darin] Providence Sacred Heart Consistent Care Program, Spokane, WA USA. [Tauben, David J.] Univ Washington, Dept Med, Seattle, WA USA. RP Franklin, G (reprint author), 130 Nickerson St,Suite 212, Seattle, WA 98109 USA. EM meddir@uw.edu NR 46 TC 19 Z9 20 U1 1 U2 9 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD MAR PY 2015 VL 105 IS 3 BP 463 EP 469 DI 10.2105/AJPH.2014.302367 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CH5DP UT WOS:000354055100026 PM 25602880 ER PT J AU Komar, N Colborn, JM Horiuchi, K Delorey, M Biggerstaff, B Damian, D Smith, K Townsend, J AF Komar, Nicholas Colborn, James M. Horiuchi, Kalanthe Delorey, Mark Biggerstaff, Brad Damian, Dan Smith, Kirk Townsend, John TI Reduced West Nile Virus Transmission Around Communal Roosts of Great-Tailed Grackle (Quiscalus mexicanus) SO ECOHEALTH LA English DT Article DE arbovirus; bird; ecology; epidemiology; risk factors; transmission; communal roost ID VECTOR-HOST INTERACTIONS; AVIAN HOSTS; SOUTHERN CALIFORNIA; DIPTERA-CULICIDAE; CULEX-TARSALIS; UNITED-STATES; EPIDEMIOLOGY; BIRDS; INFECTION; BEHAVIOR AB West Nile virus has caused several outbreaks among humans in the Phoenix metropolitan area (Arizona, southwest USA) within the last decade. Recent ecologic studies have implicated Culex quinquefasciatus and Culex tarsalis as the mosquito vectors and identified three abundant passerine birds-great-tailed grackle (Quiscalus mexicanus), house sparrow (Passer domesticus), and house finch (Haemorhous mexicanus)as key amplifiers among vertebrates. Nocturnal congregations of certain species have been suggested as critical for late summer West Nile virus amplification. We evaluated the hypothesis that house sparrow (P. domesticus) and/or great-tailed grackle (Q. mexicanus) communal roost sites (n = 22 and n = 5, respectively) in a primarily suburban environment were spatially associated with West Nile virus transmission indices during the 2010 outbreak of human neurological disease in metropolitan Phoenix. Spatial associations between human case residences and communal roosts were non-significant for house sparrows, and were negative for great-tailed grackle. Several theories that explain these observations are discussed, including the possibility that grackle communal roosts are protective. C1 [Komar, Nicholas; Colborn, James M.; Horiuchi, Kalanthe; Delorey, Mark; Biggerstaff, Brad] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. [Colborn, James M.] Idaho Dept Hlth & Welf, Boise, ID 83704 USA. [Damian, Dan; Smith, Kirk; Townsend, John] Maricopa Cty Environm Serv Dept, Vector Control Div, Phoenix, AZ 85009 USA. RP Komar, N (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, 3156 Rampart Rd, Ft Collins, CO 80521 USA. EM nck6@cdc.gov FU Centers for Disease Control and Prevention FX We thank the Maricopa County Environmental Services Department Vector Control Division and the Maricopa County Department of Public Health staff for generating the mosquito and human surveillance data used for this study. Funding was provided by the Centers for Disease Control and Prevention. The authors declare no conflict of interest. The statements and opinions expressed in this article are those of the authors and do not necessarily represent official policy of the institutions with which the authors are affiliated. NR 36 TC 0 Z9 0 U1 2 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1612-9202 EI 1612-9210 J9 ECOHEALTH JI EcoHealth PD MAR PY 2015 VL 12 IS 1 BP 144 EP 151 DI 10.1007/s10393-014-0993-0 PG 8 WC Biodiversity Conservation; Ecology; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA CH3EK UT WOS:000353910000014 PM 25480320 ER PT J AU Gibson, D Kagucia, E Omondi, B O'Brien, K Feikin, D AF Gibson, D. Kagucia, E. Omondi, B. O'Brien, K. Feikin, D. TI Association between delayed pentavalent vaccination and immunisation drop-out in rural western Kenya: findings from a cross-sectional survey SO LANCET GLOBAL HEALTH LA English DT Meeting Abstract C1 [Gibson, D.; Kagucia, E.; O'Brien, K.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA. [Omondi, B.] Kenya Govt Med Res Ctr, Kisumu, Kenya. [Omondi, B.] Ctr Dis Control & Prevent Publ Hlth Collaborat, Kisumu, Kenya. [Feikin, D.] Ctr Dis Control & Prevent, Atlanta, GA USA. EM dgibso28@jhu.edu FU Bill and Melinda Gates Foundation FX The Bill and Melinda Gates Foundation. NR 0 TC 0 Z9 0 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 2214-109X J9 LANCET GLOB HEALTH JI Lancet Glob. Health PD MAR PY 2015 VL 3 SU 1 BP 28 EP 28 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CG9GP UT WOS:000353623200028 ER PT J AU Cui, WJ Zack, MM Kobau, R Helmers, SL AF Cui, Wanjun Zack, Matthew M. Kobau, Rosemarie Helmers, Sandra L. TI Health behaviors among people with epilepsy-Results from the 2010 National Health Interview Survey SO EPILEPSY & BEHAVIOR LA English DT Article DE Epilepsy; Health behaviors; Alcohol use; Smoking behavior; Physical activity; Sleep pattern; National Health Interview Survey ID FACTOR SURVEILLANCE SYSTEM; PHYSICAL-EXERCISE; RISK-FACTORS; PREVALENCE; ALCOHOL; SEIZURES; SMOKING; ADULTS; SLEEP AB Objectives: This study aimed to estimate and compare the prevalence of selected health behavior-alcohol use, cigarette smoking, physical activity, and sufficient sleep-between people with and without a history of epilepsy in a large, nationally representative sample in the United States. Methods: We used data from the 2010 cross-sectional National Health Interview Survey (NHIS) to compare the prevalence of each health behavior for people with and without epilepsy while adjusting for sex, age, race/ethnicity, and family income. We also further categorized those with epilepsy into active epilepsy and inactive epilepsy and calculated their corresponding prevalences. Results: The percentages of adults with a history of epilepsy (50.1%, 95% CI = 45.1%-55.2%) and with active epilepsy (44.4%, 95% CI = 37.6%-51.5%) who were current alcohol drinkers were significantly lower than that of those without epilepsy (65.1%, 95% CI = 64.2%-66.0%). About 21.8% (95% CI = 18.1%-25.9%) of adults with epilepsy and 19.3% (95% CI = 18.7%-19.9%) of adults without epilepsy were current smokers. Adults with active epilepsy were significantly less likely than adults without epilepsy to report following recommended physical activity guidelines for Americans (35.2%, 95% CI = 28.8%-42.1% vs. 46.3%, 95% CI = 45.4%-47.2%) and to report walking for at least ten minutes during the seven days prior to being surveyed (39.6%, 95% CI = 32.3%-47.4% vs. 50.8%, 95% CI = 49.9%-51.7%). The percentage of individuals with active epilepsy (49.8%, 95% CI = 42.0%-57.7%) who reported sleeping an average of 7 or 8 h a day was significantly lower than that of those without epilepsy (61.9%, 95% CI = 61.2%-62.7%). Conclusions: Because adults with epilepsy are significantly less likely than adults without epilepsy to engage in recommended levels of physical activity and to get the encouraged amount of sleep for optimal health and well-being, promoting more safe physical activity and improved sleep quality is necessary among adults with epilepsy. Ending tobacco use and maintaining low levels of alcohol consumption would also better the health of adults with epilepsy. Published by Elsevier Inc. C1 [Cui, Wanjun; Zack, Matthew M.; Kobau, Rosemarie] Natl Ctr Chron Dis Prevent & Hlth Promot, Centers Dis Control & Prevent, Div Populat Hlth, Epilepsy Program, Atlanta, GA 30341 USA. [Helmers, Sandra L.] Emory Univ, Rollins Sch Publ Hlth, Sch Med, Dept Neurol,Dept Hlth Policy, Atlanta, GA 30322 USA. RP Cui, WJ (reprint author), Div Populat Hlth, 4770 Buford Highway NE,MS F-78, Atlanta, GA 30341 USA. EM wtd9@cdc.gov FU CDC through Oak Ridge Institute for Science and Education (ORISE) fellowship program FX The project was undertaken while Wanjun Cui was under contract with CDC through the Oak Ridge Institute for Science and Education (ORISE) fellowship program. NR 40 TC 5 Z9 5 U1 1 U2 7 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1525-5050 EI 1525-5069 J9 EPILEPSY BEHAV JI Epilepsy Behav. PD MAR PY 2015 VL 44 BP 121 EP 126 DI 10.1016/j.yebeh.2015.01.011 PG 6 WC Behavioral Sciences; Clinical Neurology; Psychiatry SC Behavioral Sciences; Neurosciences & Neurology; Psychiatry GA CG4AI UT WOS:000353221600023 PM 25678033 ER PT J AU Price, P Kobau, R Buelow, J Austin, J Lowenberg, K AF Price, P. Kobau, R. Buelow, J. Austin, J. Lowenberg, K. TI Improving understanding, promoting social inclusion, and fostering empowerment related to epilepsy: Epilepsy Foundation public awareness campaigns-2001 through 2013 SO EPILEPSY & BEHAVIOR LA English DT Article DE Epilepsy; Seizures; Stigma; Health communication; Public awareness campaigns ID US POPULATION; STIGMA; ATTITUDES; KNOWLEDGE; FAMILIARITY; PERCEPTIONS; PROGRAM; ADULTS AB It is a significant public health concern that epilepsy, the fourth most common neurological disorder in the United States, is generally poorly understood by both the public and those living with the condition. Lack of understanding may magnify the challenges faced by those with epilepsy, including limiting treatment opportunities, effective management of symptoms, and full participation in daily life activities. Insufficient awareness of epilepsy and appropriate seizure first aid among the public and professionals can result in insufficient treatment, inappropriate seizure response, physical restraint, social exclusion, or other negative consequences. To address the need for increased public education and awareness about epilepsy, the national Epilepsy Foundation, supported by the Centers for Disease Control and Prevention, has conducted yearly multifaceted public education and awareness campaigns designed to reach the broad population and targeted segments of the population including youth, young adults, racial/ethnic groups (i.e., African-, Hispanic-, and Asian-Americans), and people with epilepsy and their caregivers. Campaign channels have included traditional media, social media, and community opinion leaders and celebrity spokespersons. The key activities of these campaigns, conducted from 2001 to 2013, are summarized in this report. Published by Elsevier Inc. C1 [Price, P.] McKing & Associates, Atlanta, GA USA. [Kobau, R.] Ctr Dis Control & Prevent, Div Populat Hlth, Epilepsy Program, Atlanta, GA 30341 USA. [Buelow, J.; Lowenberg, K.] Natl Epilepsy Fdn, Landover, MD USA. RP Kobau, R (reprint author), Ctr Dis Control & Prevent, Div Populat Hlth, Epilepsy Program, 4770 Buford Highway NE,MS F-78, Atlanta, GA 30341 USA. EM rkobau@cdc.gov FU CDC through McKing and Associates, Atlanta, GA [RFP PR-73463]; CDC [5U58DP003832-03] FX Patricia Price is supported by CDC through a contract with McKing and Associates, Atlanta, GA (RFP PR-73463).; Jan Buelow and Ken Lowenberg are employees of the Epilepsy Foundation. This publication was supported by cooperative agreement no. 5U58DP003832-03 from the CDC. The findings and conclusions in this study are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 20 TC 8 Z9 8 U1 0 U2 9 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1525-5050 EI 1525-5069 J9 EPILEPSY BEHAV JI Epilepsy Behav. PD MAR PY 2015 VL 44 BP 239 EP 244 DI 10.1016/j.yebeh.2014.12.044 PG 6 WC Behavioral Sciences; Clinical Neurology; Psychiatry SC Behavioral Sciences; Neurosciences & Neurology; Psychiatry GA CG4AI UT WOS:000353221600043 PM 25726152 ER PT J AU Schenker, N AF Schenker, Nathaniel TI Why Your Involvement Matters SO JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION LA English DT Editorial Material AB The International Year of Statistics, 2013, focused on outreach in a wonderful way. As we celebrate the ASA's 175th anniversary in 2014, it is worthwhile to look inward as well and think about how to keep our association and profession strong, so that our successors will be able to celebrate the 275th anniversary. The ASA, with its long history, its fine staff and organization, and its financial resource base, is well positioned to serve the profession, and indeed society, and it is very successful at doing so. But the real measure of the health of our association is the size and level of engagement of its membership, whose participation is a major source of the ASA's strength. So, what is it that compels people to be members? One might argue that it is the tangible benefits that we receive in exchange for our duesmagazine and journal subscriptions, discounted meeting registrations, and so on. Although such benefits are attractive, I believe they are not the primary reasons people are ASA members. What compels people is the value they find through involvement in the association. Unlike benefits, which are objective, value is subjective, varying over time and varying from member to member or group to group. And unlike benefits, which can be listed as bullet points, value is best borne out in personal experiences. In this address, I will use experiences that ASA members have shared with me, along with experiences of my own, to paint a picture of the deep value that involvement in the ASA has provided. I also will challenge you to continue to find the extraordinary value available through involvement in our association. C1 [Schenker, Nathaniel] Amer Stat Assoc, Alexandria, VA 22314 USA. [Schenker, Nathaniel] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Atlanta, GA USA. EM natschenker@gmail.com NR 0 TC 0 Z9 0 U1 2 U2 2 PU AMER STATISTICAL ASSOC PI ALEXANDRIA PA 732 N WASHINGTON ST, ALEXANDRIA, VA 22314-1943 USA SN 0162-1459 EI 1537-274X J9 J AM STAT ASSOC JI J. Am. Stat. Assoc. PD MAR PY 2015 VL 110 IS 509 BP 1 EP 5 DI 10.1080/01621459.2015.1021616 PG 5 WC Statistics & Probability SC Mathematics GA CG7HS UT WOS:000353474200001 ER PT J AU Kim, S Valdez, R AF Kim, Sunkyung Valdez, Rodolfo TI Metabolic risk factors in US youth with low relative muscle mass SO OBESITY RESEARCH & CLINICAL PRACTICE LA English DT Article DE Muscle mass; Fat mass; CVD/DM risk factors; NHANES ID DUCHENNE MUSCULAR-DYSTROPHY; CARDIOVASCULAR-DISEASE; BODY-COMPOSITION; CHILDREN; ADOLESCENTS; OBESITY; FAT; CHILDHOOD; HEALTH; INDEX AB Aims: To examine the association between relative muscle mass (RMM) and nine risk factors for cardiovascular disease and diabetes (CVD/DM) in U.S. youth. Methods: We used a sample representative of the U.S. population of youth, aged 8-20 years (NHANES 1999-2004). We compared the prevalence of adverse levels of nine CVD/DM risk factors between youths in the lowest quartile of RMM and their peers in the remaining quartiles, controlling for age, sex, and race/ethnicity. We also examined variations in the adjusted prevalence of these risk factors along the entire range of RMM. Results: The adjusted prevalence of adverse levels of risk factors among youths in the lowest quartile of RMM was significantly higher for seven of the nine risk factors examined compared with their peers in the other quartiles. Over the entire range of RMM, the adjusted prevalence of adverse levels of each of these seven risk factors decreased gradually with increasing RMM values (all p for trend <0.001). Conclusions: RMM and prevalence of adverse risk factors for CVD/DM are highly and inversely associated in U.S. youth. Among youth with low RMM, the risk of these chronic diseases could be significantly high later in life. (C) 2014 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved. C1 [Kim, Sunkyung; Valdez, Rodolfo] Ctr Dis Control & Prevent, Div Human Dev & Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Kim, S (reprint author), Ctr Dis Control & Prevent, Div Human Dev & Disabil, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd NE,Mailstop E88, Atlanta, GA 30333 USA. EM wox0@cdc.gov FU Intramural CDC HHS [CC999999] NR 30 TC 1 Z9 1 U1 1 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1871-403X EI 1878-0318 J9 OBES RES CLIN PRACT JI Obes. Res. Clin. Pract. PD MAR-APR PY 2015 VL 9 IS 2 BP 125 EP 132 DI 10.1016/j.orcp.2014.05.002 PG 8 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA CG1XJ UT WOS:000353068500003 PM 25890427 ER PT J AU Ren, P Luo, M Lin, S Ghannoum, MA Isham, N Diekema, DJ Pfaller, MA Messer, S Lockhart, SR Iqbal, N Chaturvedi, V AF Ren, Ping Luo, Ming Lin, Shao Ghannoum, Mahmoud A. Isham, Nancy Diekema, Dan J. Pfaller, Michael A. Messer, Shawn Lockhart, Shawn R. Iqbal, Naureen Chaturvedi, Vishnu TI Multilaboratory Testing of Antifungal Drug Combinations against Candida Species and Aspergillus fumigatus: Utility of 100 Percent Inhibition as the Endpoint SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID INVASIVE FUNGAL-INFECTIONS; FIXED-DOSE COMBINATION; THERAPY; SURVEILLANCE; RIFAMPICIN AB Four laboratories tested three isolates of Candida species and two isolates of Aspergillus fumigatus using 96-well plates containing combinations of amphotericin B, anidulafungin, caspofungin, micafungin, fluconazole, itraconazole, posaconazole, and voriconazole. The majority of summation fractional inhibitory concentration indices (Sigma FICI) based on the Lowe additivity formula suggested indifferent drug interactions (Sigma FICI > 0.5 and <= 4.0) and no instance of drug antagonism (Sigma FICI > 4.0). The intra-and interlaboratory agreement rates were superior when MIC100 readings were used as endpoints (at a 99% confidence interval [CI]). C1 [Ren, Ping; Chaturvedi, Vishnu] New York State Dept Hlth, Wadsworth Ctr, Mycol Lab, Albany, NY 12208 USA. [Luo, Ming; Lin, Shao] New York State Dept Hlth, Bur Environm & Occupat Epidemiol, Albany, NY USA. [Ghannoum, Mahmoud A.; Isham, Nancy] Case Western Reserve Univ, Ctr Med Mycol, Cleveland, OH 44106 USA. [Ghannoum, Mahmoud A.; Isham, Nancy] Univ Hosp Case Med Ctr, Cleveland, OH USA. [Diekema, Dan J.; Pfaller, Michael A.; Messer, Shawn] Univ Iowa, Dept Pathol, Div Med Microbiol, Iowa City, IA 52242 USA. [Lockhart, Shawn R.; Iqbal, Naureen] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA USA. RP Ren, P (reprint author), New York State Dept Hlth, Wadsworth Ctr, Mycol Lab, Albany, NY 12208 USA. EM ping.ren@health.ny.gov OI Lin, Shao/0000-0002-5535-7504 FU Wadsworth Center Clinical Laboratory Reference System; Astellas USA, Merck Co.; Pfizer Inc.; Schering-Plough Research Institute FX This study was supported in part by funds from the Wadsworth Center Clinical Laboratory Reference System (V.C.). Additional support came in the form of investigative grants from Astellas USA, Merck & Co., Pfizer Inc., and Schering-Plough Research Institute (V.C.). Trek Diagnostic Systems partially subsidized the cost of custom 96-well plates. NR 25 TC 1 Z9 1 U1 1 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD MAR PY 2015 VL 59 IS 3 BP 1764 EP 1771 DI 10.1128/AAC.04545-14 PG 8 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA CF4VF UT WOS:000352550000049 PM 25512402 ER PT J AU An, DTM Minh, HV Huong, LT Giang, KB Xuan, LTT Nga, PTQ Hsia, J AF Dao Thi Minh An Hoang Van Minh Le Thi Huong Kim Bao Giang Le Thi Thanh Xuan Pham Thi Quynh Nga Hsia, Jason TI Attitudes Toward Nonsmoking Policies and Tobacco Tax Increases: A Cross-sectional Study Among Vietnamese Adults SO ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH LA English DT Article DE attitude; smoking control policies; global adult tobacco use survey; Vietnam AB Following the 2009 update of the 2005 Framework Convention on Tobacco Control, Vietnam issued a new policy to ban smoking at workplaces and public places. This cross-sectional survey explored public attitudes toward this new regulation and provides evidence to inform future laws. Using stratified cluster sampling, 10 383 Vietnamese people older than 15 years were drawn from 11 142 selected households. Policies mandating "no smoking at workplaces" were supported by 88.7% of Vietnamese adults, whereas "no smoking in public places" and "increasing the tobacco tax" received less support. Educational level, knowledge of health effects, access to information on quitting and smoking health risks, smoking status, ethnicity, and region had significant associations with positive attitudes toward all 3 tobacco control policies. Adults belonging to the non-Kinh ethnic group, those who do not live in the Red river delta, people with lower educational levels, and current smokers should be targeted in tobacco control communication programs. C1 [Dao Thi Minh An; Hoang Van Minh; Le Thi Huong; Kim Bao Giang; Le Thi Thanh Xuan] Hanoi Med Univ, Hanoi 100803, Vietnam. [Pham Thi Quynh Nga] World Hlth Org Off Viet Nam, Hanoi, Vietnam. [Hsia, Jason] Ctr Dis Control & Prevent, Atlanta, GA USA. RP An, DTM (reprint author), Hanoi Med Univ, Inst Prevent Med & Publ Hlth, 1 Ton That Tung, Hanoi 100803, Vietnam. EM daothiminhan@yahoo.com FU WHO FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was financially supported by WHO and technically supported by CDC. NR 17 TC 0 Z9 0 U1 1 U2 4 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1010-5395 EI 1941-2479 J9 ASIA-PAC J PUBLIC HE JI Asia-Pac. J. Public Health PD MAR PY 2015 VL 27 IS 2 BP NP947 EP NP957 DI 10.1177/1010539512460568 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CF5GT UT WOS:000352586200093 ER PT J AU Goyet, S Rammaert, B McCarron, M Khieu, V Fournier, I Kitsutani, P Ly, S Mounts, A Letson, WG Buchy, P Vong, S AF Goyet, Sophie Rammaert, Blandine McCarron, Margaret Khieu, Virak Fournier, Isabelle Kitsutani, Paul Ly, Sowath Mounts, Anthony Letson, William G. Buchy, Philippe Vong, Sirenda TI Mortality in Cambodia: An 18-Month Prospective Community-based Surveillance of All-age Deaths Using Verbal Autopsies SO ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH LA English DT Article DE mortality; rural health; Cambodia; verbal autopsy ID DIAGNOSTIC GOLD STANDARDS; RURAL CAMBODIA; SOUTHEAST-ASIA; VALIDATION; HEALTH; PERFORMANCE; INFLUENZA AB To estimate the 2009-2010 death rates, causes, and patterns of mortality in rural Cambodia, we conducted active, population-based death surveillance in 25 rural villages of Cambodia from March 2009 to August 2010. Among the population of 28 053 under surveillance, 280 deaths were reported and explored by physician-certified verbal autopsies, using the International Classification of Diseases 10, yielding an overall mortality rate (MR) of 6.7/1000 persons-year (95% CI 5.74-7.68). The MR was 39.1/1000 live births for those younger than 5 years old. Infants accounted for 5.4% of all deaths. In children younger than 5 years, infectious and parasitic diseases were the leading causes of death. In children 5 to 14 years, 3 out of 4 deaths were due to injuries. Adult deaths were mainly attributed to noncommunicable diseases (52%). We conclude that this rural population is facing a substantial burden of noncommunicable diseases while still struggling with infectious diseases, respiratory diseases in particular. C1 [Goyet, Sophie; Rammaert, Blandine; Khieu, Virak; Fournier, Isabelle; Ly, Sowath; Buchy, Philippe; Vong, Sirenda] Inst Pasteur Cambodia, Phnom Penh, Cambodia. [McCarron, Margaret; Kitsutani, Paul; Mounts, Anthony] Ctr Dis Control & Prevent, Atlanta, GA USA. [Letson, William G.] Int Vaccine Inst, Seoul, South Korea. RP Goyet, S (reprint author), Inst Pasteur Cambodia, 5 Blvd Monivong,BP 983, Phnom Penh, Cambodia. EM sophiegoyet@gmail.com OI Goyet, Sophie/0000-0002-1835-4478 FU US Centers for Disease Control and Prevention [1U01IP000148-01]; Pediatric Dengue Vaccine Initiative, Seoul, Republic of Korea; Bill & Melinda Gates Foundation [23197] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The present study was funded by the US Centers for Disease Control and Prevention (grant 1U01IP000148-01). The study benefited from the surveillance site that was funded by the Pediatric Dengue Vaccine Initiative, Seoul, Republic of Korea, which received funding from the Bill & Melinda Gates Foundation (grant 23197). NR 29 TC 0 Z9 0 U1 1 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1010-5395 EI 1941-2479 J9 ASIA-PAC J PUBLIC HE JI Asia-Pac. J. Public Health PD MAR PY 2015 VL 27 IS 2 BP NP2458 EP NP2470 DI 10.1177/1010539513514433 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CF5GT UT WOS:000352586200228 PM 24357610 ER PT J AU Leung, J Bialek, SR Marin, M AF Leung, Jessica Bialek, Stephanie R. Marin, Mona TI Trends in varicella mortality in the United States: Data from vital statistics and the national surveillance system SO HUMAN VACCINES & IMMUNOTHERAPEUTICS LA English DT Article DE CDC; NCHS; surveillance; varicella deaths; varicella mortality; vaccine-preventable disease; varicella vaccine; VZV ID VACCINATION PROGRAM; ZOSTER-VIRUS; SAFETY PROFILE; HOSPITALIZATIONS; IMPLEMENTATION; LICENSURE; DEATHS; IMPACT; CHILD; US AB This manuscript describes trends in US varicella mortality using national vital statistics system data for 2008-2011, the first years of the routine 2-dose varicella vaccination program, and characteristics of varicella deaths reported to CDC during 1996-2013. We obtained data on deaths with varicella as underlying or contributing cause from the 2008-2011 Mortality Multiple Cause-of Death records and calculated rates to compare with the prevaccine and mature 1-dose varicella vaccination program eras. We also reviewed available records of varicella deaths reported to CDC through the national varicella death surveillance. The annual average age-adjusted mortality rate for varicella as the underlying cause was 0.05 per million population during 2008-2011, an 87% reduction from the prevaccine years. Varicella deaths among persons aged <20 y declined by 99% in 2008-2011 compared with prevaccine years. There was a 70% decline in varicella mortality rates among those <20 y in 2008-2011 compared to 2005-2007. Among the 83 deaths reported to CDC during 1996-2013 classified as likely due to varicella, 24 (29%) were among immunocompromised individuals. Five were among persons previously vaccinated with 1 dose of varicella vaccine. In conclusion, although the US varicella vaccination program has significantly reduced varicella disease burden, there are still opportunities to prevent varicella and its associated morbidity and mortality through routine varicella vaccination, catch-up vaccination, and ensuring that household contacts of immunocompromised persons have evidence of immunity. C1 [Leung, Jessica; Bialek, Stephanie R.; Marin, Mona] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Leung, J (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM JLeung@cdc.gov NR 23 TC 4 Z9 4 U1 0 U2 1 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 2164-5515 EI 2164-554X J9 HUM VACC IMMUNOTHER JI Human Vaccines Immunother. PD MAR PY 2015 VL 11 IS 3 BP 662 EP 668 DI 10.1080/21645515.2015.1008880 PG 7 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA CF5SA UT WOS:000352616100024 PM 25714052 ER PT J AU Hodge, JG Penn, MS Ransom, M Jordan, JE AF Hodge, James G. Penn, Matthew S. Ransom, Montrece Jordan, Jane E. TI Domestic Legal Preparedness and Response to Ebola SO JOURNAL OF LAW MEDICINE & ETHICS LA English DT Article; Proceedings Paper CT National Public Health Law Conference - Intersection of Law, Policy and Prevention CY OCT, 2014 CL Atlanta, GA SP Network Public Hlth Law, Ame Soc Law, Med & Eth AB Initial cases of Ebola in the U.S. raise varied legal issues as discussed at a late-breaking session at the 2014 Public Health Law conference. Session presenters share their perspectives on (1) state and local powers to quarantine and isolate persons, and (2) hospital preparedness underlying the treatment of Ebola patients. C1 [Hodge, James G.] Arizona State Univ, Grants & External Funding, Sandra Day OConnor Coll Law, Tempe, AZ 85287 USA. [Hodge, James G.] Arizona State Univ, Publ Hlth Law & Eth, Sandra Day OConnor Coll Law, Tempe, AZ 85287 USA. [Hodge, James G.] Arizona State Univ, Publ Hlth Law & Policy Program, Sandra Day OConnor Coll Law, Tempe, AZ 85287 USA. [Penn, Matthew S.] Ctr Dis Control & Prevent CDC, Publ Hlth Law Program, Off State Tribal Local & Terr Support, Washington, DC USA. [Ransom, Montrece] CDC, Publ Hlth Law Program, Off State Tribal Local & Terr Support, Atlanta, GA 30333 USA. [Jordan, Jane E.] Emory Univ, Hlth Affairs, Off Gen Counsel, Atlanta, GA 30322 USA. RP Hodge, JG (reprint author), Arizona State Univ, Grants & External Funding, Sandra Day OConnor Coll Law, Tempe, AZ 85287 USA. NR 5 TC 2 Z9 2 U1 1 U2 4 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1073-1105 EI 1748-720X J9 J LAW MED ETHICS JI J. Law Med. Ethics PD SPR PY 2015 VL 43 SU 1 SI SI BP 15 EP 18 DI 10.1111/jlme.12207 PG 4 WC Ethics; Law; Medical Ethics; Medicine, Legal SC Social Sciences - Other Topics; Government & Law; Medical Ethics; Legal Medicine GA CF5CS UT WOS:000352573600003 PM 25846156 ER PT J AU Ramanathan, T Schmit, C Menon, A Fox, C AF Ramanathan, Tara Schmit, Cason Menon, Akshara Fox, Chanelle TI The Role of Law in Supporting Secondary Uses of Electronic Health Information SO JOURNAL OF LAW MEDICINE & ETHICS LA English DT Article; Proceedings Paper CT National Public Health Law Conference - Intersection of Law, Policy and Prevention CY OCT, 2014 CL Atlanta, GA SP Network Public Hlth Law, Ame Soc Law, Med & Eth ID PUBLIC-HEALTH AB Law establishes the foundation for the secondary use of electronic health information (EHI) for public health purposes. Federal law, state law, and legal tools, such as contracts and policies, support data exchange between providers, facilities, and public health departments. This article describes the legal landscape surrounding secondary use of EHI. C1 [Ramanathan, Tara] Ctr Dis Control & Prevent CDC, PHLP, Atlanta, GA 30333 USA. [Ramanathan, Tara] PHLP, Efforts Promote Legal Epidemiol & Oversees Res Pr, Atlanta, GA USA. [Schmit, Cason] PHLP, Atlanta, GA USA. [Schmit, Cason] CDC Ctr & off, Atlanta, GA USA. [Menon, Akshara] CDC, PHLP, Atlanta, GA 30333 USA. [Fox, Chanelle] Indiana Univ, Maurer Sch Law, Bloomington, IN 47405 USA. [Fox, Chanelle] Indiana Univ, Bloomington, IN 47405 USA. RP Ramanathan, T (reprint author), Ctr Dis Control & Prevent CDC, PHLP, Atlanta, GA 30333 USA. FU Intramural CDC HHS [CC999999] NR 15 TC 0 Z9 0 U1 0 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1073-1105 EI 1748-720X J9 J LAW MED ETHICS JI J. Law Med. Ethics PD SPR PY 2015 VL 43 SU 1 SI SI BP 48 EP 51 DI 10.1111/jlme.12215 PG 4 WC Ethics; Law; Medical Ethics; Medicine, Legal SC Social Sciences - Other Topics; Government & Law; Medical Ethics; Legal Medicine GA CF5CS UT WOS:000352573600011 PM 25846164 ER PT J AU Somerville, MH Seeff, L Hale, D O'Brien, DJ AF Somerville, Martha H. Seeff, Laura Hale, Daniel O'Brien, Daniel J. TI Hospitals, Collaboration, and Community Health Improvement SO JOURNAL OF LAW MEDICINE & ETHICS LA English DT Article; Proceedings Paper CT National Public Health Law Conference - Intersection of Law, Policy and Prevention CY OCT, 2014 CL Atlanta, GA SP Network Public Hlth Law, Ame Soc Law, Med & Eth AB This article explores how the ACA's community health needs assessment requirement and the Community Reinvestment Act can encourage collaboration among tax-exempt hospitals, public health agencies, financial institutions, and communities to improve population health through aligned health improvement planning and initiatives to address social, economic, and environmental factors that affect health. C1 [Somerville, Martha H.] Somerville Consulting, Somerville, MA 02144 USA. [Seeff, Laura] Ctr Dis Control & Prevent, Off Hlth Syst Collaborat, Off Associate Director Policy, Washington, DC USA. [Hale, Daniel] CHE Trinity Hlth, Community Benefit, Livonia, MI USA. [O'Brien, Daniel J.] Network Publ Hlth Law, Princeton, NJ USA. RP Somerville, MH (reprint author), Somerville Consulting, Somerville, MA 02144 USA. NR 19 TC 1 Z9 1 U1 0 U2 8 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1073-1105 EI 1748-720X J9 J LAW MED ETHICS JI J. Law Med. Ethics PD SPR PY 2015 VL 43 SU 1 SI SI BP 56 EP 59 DI 10.1111/jlme.12217 PG 4 WC Ethics; Law; Medical Ethics; Medicine, Legal SC Social Sciences - Other Topics; Government & Law; Medical Ethics; Legal Medicine GA CF5CS UT WOS:000352573600013 PM 25846166 ER PT J AU Church, J Ekechi, CO Hoss, A Larson, AJ AF Church, Jerilyn Ekechi, Chinyere O. Hoss, Aila Larson, Anika Jade TI Tribal Water Rights: Exploring Dam Construction in Indian Country SO JOURNAL OF LAW MEDICINE & ETHICS LA English DT Article; Proceedings Paper CT National Public Health Law Conference - Intersection of Law, Policy and Prevention CY OCT, 2014 CL Atlanta, GA SP Network Public Hlth Law, Ame Soc Law, Med & Eth ID CLIMATE-CHANGE; IMPACTS AB This paper examines the legal and policy framework related to Tribal water rights, with a key focus on the environmental public health impacts of dam construction in Indian Country. Three dam projects will be highlighted: the Dalles Dam, the Elwha River Dams, and the Pick-Sloan Missouri River Basin Program. C1 [Church, Jerilyn] Great Plains Tribal Chairmens Hlth Board, Rapid City, SD 57702 USA. [Ekechi, Chinyere O.] Ctr Dis Control & Prevent, Agcy Tox Subst & Dis Registry, De Kalb, GA USA. [Hoss, Aila] Ctr Dis Control & Prevent, Oak Ridge Inst Sci & Educ, Publ Hlth Law Program, Off State Tribal Local & Terr Support, De Kalb, GA USA. [Larson, Anika Jade] Ctr Dis Control & Prevent, Environm Hlth Intern, De Kalb, GA USA. RP Church, J (reprint author), Great Plains Tribal Chairmens Hlth Board, Rapid City, SD 57702 USA. FU Intramural CDC HHS [CC999999] NR 9 TC 2 Z9 2 U1 5 U2 18 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1073-1105 EI 1748-720X J9 J LAW MED ETHICS JI J. Law Med. Ethics PD SPR PY 2015 VL 43 SU 1 SI SI BP 60 EP 63 DI 10.1111/jlme.12218 PG 4 WC Ethics; Law; Medical Ethics; Medicine, Legal SC Social Sciences - Other Topics; Government & Law; Medical Ethics; Legal Medicine GA CF5CS UT WOS:000352573600014 PM 25846167 ER PT J AU Paddock, CD Goddard, J AF Paddock, Christopher D. Goddard, Jerome TI The Evolving Medical and Veterinary Importance of the Gulf Coast tick (Acari: Ixodidae) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Gulf Coast tick; Amblyomma maculatum; Rickettsia parkeri; Hepatozoon americanum ID AMBLYOMMA-MACULATUM ACARI; FEVER GROUP RICKETTSIAE; WHITE-TAILED DEER; MOUNTAIN-SPOTTED-FEVER; HEPATOZOON-AMERICANUM APICOMPLEXA; LONE STAR TICKS; EASTERN UNITED-STATES; NATURALLY INFECTED-DOGS; ACTIN-BASED MOTILITY; 16S RDNA SEQUENCES AB Amblyomma maculatum Koch (the Gulf Coast tick) is a three-host, ixodid tick that is distributed throughout much of the southeastern and south-central United States, as well as several countries throughout Central and South America. A considerable amount of scientific literature followed the original description of A. maculatum in 1844; nonetheless, the Gulf Coast tick was not recognized as a vector of any known pathogen of animals or humans for >150 years. It is now identified as the principal vector of Hepatozoon americanum, the agent responsible for American canine hepatozoonosis, and Rickettsia parkeri, the cause of an emerging, eschar-associated spotted fever group rickettsiosis identified throughout much of the Western Hemisphere. Coincident with these discoveries has been recognition that the geographical distribution of A. maculatum in the United States is far more extensive than described 70 yr ago, supporting the idea that range and abundance of certain tick species, particularly those with diverse host preferences, are not fixed in time or space, and may change over relatively short intervals. Renewed interest in the Gulf Coast tick reinforces the notion that the perceived importance of a particular tick species to human or animal health can be relatively fluid, and may shift dramatically with changes in the distribution and abundance of the arthropod, its vertebrate hosts, or the microbial agents that transit among these organisms. C1 [Paddock, Christopher D.] Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Atlanta, GA 30333 USA. [Goddard, Jerome] Mississippi State Univ, Dept Biochem Mol Biol Entomol & Plant Pathol, Starkville, MS 39762 USA. RP Paddock, CD (reprint author), Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Bldg 17,Room 3224,1600 Clifton Rd, Atlanta, GA 30333 USA. EM cdp9@cdc.gov NR 238 TC 19 Z9 19 U1 2 U2 15 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-2585 EI 1938-2928 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAR PY 2015 VL 52 IS 2 BP 230 EP 252 DI 10.1093/jme/tju022 PG 23 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA CF2UE UT WOS:000352402300016 PM 26336308 ER PT J AU Liu, J Lurain, K Sobuz, SU Begum, S Kumburu, H Gratz, J Kibiki, G Toney, D Gautam, R Bowen, MD Petri, WA Haque, R Houpt, ER AF Liu, Jie Lurain, Kate Sobuz, Shihab U. Begum, Sharmin Kumburu, Happiness Gratz, Jean Kibiki, Gibson Toney, Denise Gautam, Rashi Bowen, Michael D. Petri, William A., Jr. Haque, Rashidul Houpt, Eric R. TI Molecular genotyping and quantitation assay for rotavirus surveillance SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE Rotavirus; Diarrhea; Genotyping; Multiplex real time RT-PCR ID GROUP-A ROTAVIRUS; POLYMERASE-CHAIN-REACTION; HIGH-FREQUENCY; UNITED-STATES; VACCINE-INTRODUCTION; MIXED INFECTIONS; GUINEA-BISSAU; STRAINS; CHILDREN; DISEASE AB Rotavirus genotyping is useful for surveillance purposes especially in areas where rotavirus vaccination has been or will be implemented. RT-PCR based molecular methods have been applied widely, but quantitative assays targeting a broad spectrum of genotypes have not been developed. Three real time RT-PCR panels were designed to identify G1, G2, G9, G12 (panel GI), G3, G4, G8, G10 (panel GII), and P[4], P[6], P[8], P[10], P[11] (panel P), respectively. An assay targeting NSP3 was included in both G panels as an internal control. The cognate assays were also formulated as one RT-PCR-Luminex panel for simultaneous detection of all the genotypes listed above plus P[9]. The assays were evaluated with various rotavirus isolates and 89 clinical samples from Virginia, Bangladesh and Tanzania, and exhibited 95% (81/85) sensitivity compared with the conventional RT-PCR-Gel-electrophoresis method, and 100% concordance with sequencing. Real time assays identified a significantly higher rate of mixed genotypes in Bangladeshi samples than the conventional gel-electrophoresis-based RT-PCR assay (32.5% versus 12.5%, P < 0.05). In these mixed infections, the relative abundance of the rotavirus types could be estimated by Cq values. These typing assays detect and discriminate a broad range of G/P types circulating in different geographic regions with high sensitivity and specificity and can be used for rotavirus surveillance. (C) 2014 Elsevier B.V. All rights reserved. C1 [Liu, Jie; Lurain, Kate; Petri, William A., Jr.; Houpt, Eric R.] Univ Virginia, Dept Med, Div Infect Dis & Int Hlth, Charlottesville, VA 22903 USA. [Sobuz, Shihab U.; Begum, Sharmin; Haque, Rashidul] Int Ctr Diarrhoeal Dis Res, Dhaka, Bangladesh. [Kumburu, Happiness; Gratz, Jean; Kibiki, Gibson] Kilimanjaro Christian Res Inst, Moshi, Tanzania. [Toney, Denise] Virginia Dept Gen Serv, Div Consolidated Lab Serv, Richmond, VA USA. [Gautam, Rashi; Bowen, Michael D.] Ctr Dis Control & Prevent, Div Viral Dis, Nation Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Liu, J (reprint author), Univ Virginia, Dept Med, Div Infect Dis & Int Hlth, Charlottesville, VA 22903 USA. EM jl5yj@virginia.edu FU Bill and Melinda Gates Foundation [OPP1084328, OPP1017093]; NIH [RO1 AI043596] FX This study was supported by Bill and Melinda Gates Foundation (OPP1084328, OPP1017093) and NIH (RO1 AI043596). NR 36 TC 1 Z9 1 U1 1 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 EI 1879-0984 J9 J VIROL METHODS JI J. Virol. Methods PD MAR 1 PY 2015 VL 213 BP 157 EP 163 DI 10.1016/j.jviromet.2014.12.001 PG 7 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA CF9YF UT WOS:000352923100025 PM 25526999 ER PT J AU Park, RM Baldwin, M Bouchard, MF Mergler, D AF Park, Robert M. Baldwin, Mary Bouchard, Maryse F. Mergler, Donna TI Airborne manganese as dust vs. fume determining blood levels in workers at a manganese alloy production plant (vol 45, pg 267, 2014) SO NEUROTOXICOLOGY LA English DT Correction C1 [Park, Robert M.] US Natl Inst Occupat Safety & Hlth, Cincinnati, OH USA. [Baldwin, Mary; Bouchard, Maryse F.; Mergler, Donna] Univ Quebec Montreal, Ctr Interdisciplinary Studies Hlth Well Being Soc, Montreal, PQ, Canada. [Bouchard, Maryse F.] Univ Montreal, CHU St Justine Res Ctr, Montreal, PQ H3C 3J7, Canada. RP Park, RM (reprint author), NIOSH, Ctr Dis Control & Prevent, 1150 Tusculum Ave,SR R15, Cincinnati, OH 45226 USA. EM rhpark9@gmail.com NR 1 TC 0 Z9 0 U1 1 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X EI 1872-9711 J9 NEUROTOXICOLOGY JI Neurotoxicology PD MAR PY 2015 VL 47 BP 107 EP 107 DI 10.1016/j.neuro.2015.01.004 PG 1 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA CF9YW UT WOS:000352924800013 ER PT J AU Chan, ER Barnwell, JW Zimmerman, PA Serre, D AF Chan, Ernest R. Barnwell, John W. Zimmerman, Peter A. Serre, David TI Comparative Analysis of Field-Isolate and Monkey-Adapted Plasmodium vivax Genomes SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID HUMAN MALARIA PARASITE; NEW-WORLD MONKEYS; ANOPHELINE MOSQUITOS; GENETIC DIVERSITY; PROTEIN GENE; FALCIPARUM; ADAPTATION; KNOWLESI; INFECTIONS; CYNOMOLGI AB Significant insights into the biology of Plasmodium vivax have been gained from the ability to successfully adapt human infections to non-human primates. P. vivax strains grown in monkeys serve as a renewable source of parasites for in vitro and ex vivo experimental studies and functional assays, or for studying in vivo the relapse characteristics, mosquito species compatibilities, drug susceptibility profiles or immune responses towards potential vaccine candidates. Despite the importance of these studies, little is known as to how adaptation to a different host species may influence the genome of P. vivax. In addition, it is unclear whether these monkey-adapted strains consist of a single clonal population of parasites or if they retain the multiclonal complexity commonly observed in field isolates. Here we compare the genome sequences of seven P. vivax strains adapted to New World monkeys with those of six human clinical isolates collected directly in the field. We show that the adaptation of P. vivax parasites to monkey hosts, and their subsequent propagation, did not result in significant modifications of their genome sequence and that these monkey-adapted strains recapitulate the genomic diversity of field isolates. Our analyses also reveal that these strains are not always genetically homogeneous and should be analyzed cautiously. Overall, our study provides a framework to better leverage this important research material and fully utilize this resource for improving our understanding of P. vivax biology. C1 [Chan, Ernest R.; Serre, David] Cleveland Clin Lerner Res Inst, Genom Med Inst, Cleveland, OH 44195 USA. [Chan, Ernest R.; Zimmerman, Peter A.] Case Western Reserve Univ, Ctr Global Hlth & Dis, Cleveland, OH 44106 USA. [Barnwell, John W.] Ctr Dis Control & Prevent, Ctr Global Hlth, Div Parasit Dis & Malaria, Malaria Branch, Atlanta, GA USA. RP Chan, ER (reprint author), Cleveland Clin Lerner Res Inst, Genom Med Inst, Cleveland, OH 44195 USA. EM serred@ccf.org OI Zimmerman, Peter/0000-0002-5349-4513 FU Cleveland CTSC Pilot award; National Institute of Allergy and Infectious Diseases (NIAID) [R01 AI103228]; NIAID [R21 AI093922]; T32 Postdoctoral Fellowship in Geographic Medicine and Infectious Disease [AI007024] FX This work was funded by a Cleveland CTSC Pilot award and a National Institute of Allergy and Infectious Diseases (NIAID) award (R01 AI103228) to DS and a NIAID award (R21 AI093922) to PAZ. ERC was supported by a T32 Postdoctoral Fellowship in Geographic Medicine and Infectious Disease (AI007024). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 31 TC 5 Z9 5 U1 0 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD MAR PY 2015 VL 9 IS 3 AR e0003566 DI 10.1371/journal.pntd.0003566 PG 16 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CE9YK UT WOS:000352199400039 PM 25768941 ER PT J AU Cleton, NB Godeke, GJ Reimerink, J Beersma, MF van Doorn, HR Franco, L Goeijenbier, M Jimenez-Clavero, MA Johnson, BW Niedrig, M Papa, A Sambri, V Tami, A Velasco-Salas, ZI Koopmans, MPG Reusken, CBEM AF Cleton, Natalie B. Godeke, Gert-Jan Reimerink, Johan Beersma, Mathias F. van Doorn, H. Rogier Franco, Leticia Goeijenbier, Marco Jimenez-Clavero, Miguel A. Johnson, Barbara W. Niedrig, Matthias Papa, Anna Sambri, Vittorio Tami, Adriana Velasco-Salas, Zoraida I. Koopmans, Marion P. G. Reusken, Chantal B. E. M. TI Spot the Difference-Development of a Syndrome Based Protein Microarray for Specific Serological Detection of Multiple Flavivirus Infections in Travelers SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID WEST-NILE-VIRUS; LINKED-IMMUNOSORBENT-ASSAY; ENCEPHALITIS-VIRUS; DENGUE VIRUS; CROSS-REACTIVITY; NONSTRUCTURAL GLYCOPROTEIN; SERUM ANTIBODIES; IMMUNOGLOBULIN-M; DIAGNOSIS; NS1 AB Background The family Flaviviridae, genus Flavivirus, holds many of the world's most prevalent arboviral diseases that are also considered the most important travel related arboviral infections. In most cases, flavivirus diagnosis in travelers is primarily based on serology as viremia is often low and typically has already been reduced to undetectable levels when symptoms set in and patients seek medical attention. Serological differentiation between flaviviruses and the false-positive results caused by vaccination and cross-reactivity among the different species, are problematic for surveillance and diagnostics of flaviviruses. Their partially overlapping geographic distribution and symptoms, combined with increase in travel, and preexisting antibodies due to flavivirus vaccinations, expand the need for rapid and reliable multiplex diagnostic tests to supplement currently used methods. Goal We describe the development of a multiplex serological protein microarray using recombinant NS1 proteins for detection of medically important viruses within the genus Flavivirus. Sera from clinical flavivirus patients were used for primary development of the protein microarray. Results Results show a high IgG and IgM sensitivity and specificity for individual NS1 antigens, and limited cross reactivity, even within serocomplexes. In addition, the serology based on this array allows for discrimination between infection and vaccination response for JEV vaccine, and no cross-reactivity with TBEV and YFV vaccine induced antibodies when testing for antibodies to other flaviviruses. Conclusion Based on these data, multiplex NS1-based protein microarray is a promising tool for surveillance and diagnosis of flaviviruses. C1 [Cleton, Natalie B.; Beersma, Mathias F.; Goeijenbier, Marco; Koopmans, Marion P. G.; Reusken, Chantal B. E. M.] Erasmus MC, Virosci Dept, Rotterdam, Netherlands. [Cleton, Natalie B.; Godeke, Gert-Jan; Reimerink, Johan; Koopmans, Marion P. G.] Ctr Infect Dis Res & Screening, Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands. [van Doorn, H. Rogier] Univ Oxford, Clin Res Unit, Hosp Trop Dis, Ho Chi Minh City, Vietnam. [van Doorn, H. Rogier] Univ Oxford, Nuffield Dept Med, Ctr Trop Med, Oxford, England. [Franco, Leticia] Inst Salud Carlos III, Natl Ctr Microbiol, Arbovirus & Imported Viral Dis Lab, Madrid, Spain. [Jimenez-Clavero, Miguel A.] Inst Nacl Invest & Tecnol Agr & Alimentaria INIA, CISA, Madrid, Spain. [Johnson, Barbara W.] Ctr Dis Control & Prevent CDC, Diagnost & Reference Lab, Arboviral Dis Branch, DVBD, Ft Collins, CO USA. [Niedrig, Matthias] Robert Koch Inst, Ctr Biol Threats & Special Pathogens, Berlin, Germany. [Papa, Anna] Aristotle Univ Thessaloniki, Sch Med, Dept Microbiol, Natl Reference Ctr Arboviruses & Hemorrhag Fever, GR-54006 Thessaloniki, Greece. [Sambri, Vittorio] Univ Bologna, Microbiol Unit, DIMES, Bologna, Italy. [Sambri, Vittorio] Greater Romagna Area Hub Lab, Pievesestina, Italy. [Tami, Adriana; Velasco-Salas, Zoraida I.] Univ Groningen, Univ Med Ctr Groningen, Dept Med Microbiol, Groningen, Netherlands. [Tami, Adriana] Univ Carabobo, Dept Parasitol, Fac Ciencias Salud, Valencia, Venezuela. [Velasco-Salas, Zoraida I.] Univ Carabobo, Dept Biol, Fac Expt Ciencia & Tecnol, Valencia, Venezuela. RP Cleton, NB (reprint author), Erasmus MC, Virosci Dept, Rotterdam, Netherlands. EM n.cleton@erasmusmc.nl RI Jimenez-Clavero, Miguel A./E-3048-2010; OI Jimenez-Clavero, Miguel A./0000-0003-2125-9743; van Doorn, H Rogier/0000-0002-9807-1821; SAMBRI, VITTORIO/0000-0002-5012-7355 FU Wellcome Trust [089276] NR 40 TC 9 Z9 9 U1 1 U2 16 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD MAR PY 2015 VL 9 IS 3 AR e0003580 DI 10.1371/journal.pntd.0003580 PG 17 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CE9YK UT WOS:000352199400049 PM 25767876 ER PT J AU Errecaborde, KM Stauffer, W Cetron, M AF Errecaborde, Kaylee Myhre Stauffer, William Cetron, Martin TI Neglected Tropical Disease Control and Elimination: Is Human Displacement an Achilles Heel? SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article C1 [Errecaborde, Kaylee Myhre] Univ Minnesota, Vet Populat Med, St Paul, MN 55108 USA. [Stauffer, William] Univ Minnesota, Dept Med, Div Infect Dis, Minneapolis, MN 55455 USA. [Stauffer, William; Cetron, Martin] Ctr Dis Control & Prevent, US Dept Hlth & Human Serv, Global Migrat & Quarantine, Atlanta, GA USA. RP Errecaborde, KM (reprint author), Univ Minnesota, Vet Populat Med, St Paul, MN 55108 USA. EM myhre044@umn.edu NR 14 TC 0 Z9 0 U1 1 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD MAR PY 2015 VL 9 IS 3 AR e0003535 DI 10.1371/journal.pntd.0003535 PG 4 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CE9YK UT WOS:000352199400021 PM 25790312 ER PT J AU Halliday, JEB Knobel, DL Agwanda, B Bai, Y Breiman, RF Cleaveland, S Njenga, MK Kosoy, M AF Halliday, Jo E. B. Knobel, Darryn L. Agwanda, Bernard Bai, Ying Breiman, Robert F. Cleaveland, Sarah Njenga, M. Kariuki Kosoy, Michael TI Prevalence and Diversity of Small Mammal-Associated Bartonella Species in Rural and Urban Kenya SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID SOUTH-AFRICA; GENETIC DIVERSITY; RICKETTSIA-FELIS; RODENTS; INFECTION; HENSELAE; DISEASE; FLEAS; CONGO; SPP. AB Several rodent-associated Bartonella species are human pathogens but little is known about their epidemiology. We trapped rodents and shrews around human habitations at two sites in Kenya (rural Asembo and urban Kibera) to determine the prevalence of Bartonella infection. Bartonella were detected by culture in five of seven host species. In Kibera, 60% of Rattus rattus were positive, as compared to 13% in Asembo. Bartonella were also detected in C. olivieri (7%), Lemniscomys striatus (50%), Mastomys natalensis (43%) and R. norvegicus (50%). Partial sequencing of the citrate synthase (gltA) gene of isolates showed that Kibera strains were similar to reference isolates from Rattus trapped in Asia, America, and Europe, but that most strains from Asembo were less similar. Host species and trapping location were associated with differences in infection status but there was no evidence of associations between host age or sex and infection status. Acute febrile illness occurs at high incidence in both Asembo and Kibera but the etiology of many of these illnesses is unknown. Bartonella similar to known human pathogens were detected in small mammals at both sites and investigation of the ecological determinants of host infection status and of the public health significance of Bartonella infections at these locations is warranted. C1 [Halliday, Jo E. B.; Cleaveland, Sarah] Univ Glasgow, Boyd Orr Ctr Populat & Ecosystem Hlth, Inst Biodivers Anim Hlth & Comparat Med, Coll Med Vet & Life Sci, Glasgow, Lanark, Scotland. [Knobel, Darryn L.] Ross Univ, Sch Vet Med, Ctr Conservat Med & Ecosyst Hlth, Basseterre, St Kitts & Nevi. [Agwanda, Bernard] Natl Museums Kenya, Nairobi, Kenya. [Bai, Ying; Kosoy, Michael] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA. [Breiman, Robert F.] Div Global Hlth Protect, Atlanta, GA USA. [Breiman, Robert F.] Emory Univ, Emory Global Hlth Inst, Atlanta, GA 30322 USA. [Njenga, M. Kariuki] Kenya Med Res Inst CDC Publ Hlth & Res Collaborat, Kisumu, Kenya. [Njenga, M. Kariuki] Kenya Med Res Inst CDC Publ Hlth & Res Collaborat, Nairobi, Kenya. [Njenga, M. Kariuki] CDC Kenya, Global Dis Detect Div, Nairobi, Kenya. RP Halliday, JEB (reprint author), Univ Glasgow, Boyd Orr Ctr Populat & Ecosystem Hlth, Inst Biodivers Anim Hlth & Comparat Med, Coll Med Vet & Life Sci, Glasgow, Lanark, Scotland. EM Jo.Halliday@glasgow.ac.uk OI Cleaveland, Sarah/0000-0002-0456-0959; Halliday, Jo/0000-0002-1329-9035 FU Wellcome Trust, UK [081828/B/06/Z]; BBSRC, UK [BB/J010367/1] FX This research was supported by the Wellcome Trust, UK (http://www.wellcome.ac.uk; Grant number 081828/B/06/Z). JEBH and SC receive funding support from the BBSRC, UK (http://www.bbsrc.ac.uk; grant BB/J010367/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 41 TC 1 Z9 1 U1 1 U2 13 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD MAR PY 2015 VL 9 IS 3 AR e0003608 DI 10.1371/journal.pntd.0003608 PG 14 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CE9YK UT WOS:000352199400071 PM 25781015 ER PT J AU Harris, JR Worrell, CM Davis, SM Odero, K Mogeni, OD Deming, MS Mohammed, A Montgomery, JM Njenga, SM Fox, LM Addiss, DG AF Harris, Julie R. Worrell, Caitlin M. Davis, Stephanie M. Odero, Kennedy Mogeni, Ondari D. Deming, Michael S. Mohammed, Aden Montgomery, Joel M. Njenga, Sammy M. Fox, LeAnne M. Addiss, David G. TI Unprogrammed Deworming in the Kibera Slum, Nairobi: Implications for Control of Soil-Transmitted Helminthiases SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID ASCARIS-LUMBRICOIDES INFECTIONS; TRICHURIS-TRICHIURA; IRON-DEFICIENCY; HOOKWORM INFECTION; PHYSICAL-FITNESS; SCHOOL-CHILDREN; ANEMIA; IMPACT; ALBENDAZOLE; PREVALENCE AB Background Programs for control of soil-transmitted helminth (STH) infections are increasingly evaluating national mass drug administration (MDA) interventions. However, "unprogrammed deworming" (receipt of deworming drugs outside of nationally-run STH control programs) occurs frequently. Failure to account for these activities may compromise evaluations of MDA effectiveness. Methods We used a cross-sectional study design to evaluate STH infection and unprogrammed deworming among infants (aged 6-11 months), preschool-aged children (PSAC, aged 1-4 years), and school-aged children (SAC, aged 5-14 years) in Kibera, Kenya, an informal settlement not currently receiving nationally-run MDA for STH. STH infection was assessed by triplicate Kato-Katz. We asked heads of households with randomly-selected children about past-year receipt and source(s) of deworming drugs. Local non-governmental organizations (NGOs) and school staff participating in school-based deworming were interviewed to collect information on drug coverage. Results Of 679 children (18 infants, 184 PSAC, and 477 SAC) evaluated, 377 (55%) reported receiving at least one unprogrammed deworming treatment during the past year. PSAC primarily received treatments from chemists (48.3%) or healthcare centers (37.7%); SAC most commonly received treatments at school (55.0%). Four NGOs reported past-year deworming activities at 47 of >150 schools attended by children in our study area. Past-year deworming was negatively associated with any-STH infection (34.8% vs 45.4%, p = 0.005). SAC whose most recent deworming medication was sourced from a chemist were more often infected with Trichuris (38.0%) than those who received their most recent treatment from a health center (17.3%) or school (23.1%) (p = 0.05). Conclusion Unprogrammed deworming was received by more than half of children in our study area, from multiple sources. Both individual-level treatment and unprogrammed preventive chemotherapy may serve an important public health function, particularly in the absence of programmed deworming; however, they may also lead to an overestimation of programmed MDA effectiveness. A standardized, validated tool is needed to assess unprogrammed deworming. C1 [Harris, Julie R.; Worrell, Caitlin M.; Deming, Michael S.; Fox, LeAnne M.] Ctr Dis Control & Prevent, Parasit Dis Branch, Atlanta, GA 30333 USA. [Davis, Stephanie M.] Ctr Dis Control & Prevent, Div Global HIV AIDS, Atlanta, GA USA. [Odero, Kennedy; Mogeni, Ondari D.; Njenga, Sammy M.] Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Nairobi, Kenya. [Mohammed, Aden] Sch Hlth Program, Dept Publ Hlth, Nairobi, Kenya. [Montgomery, Joel M.] Ctr Dis Control & Prevent, Div Global Hlth Protect, Nairobi, Kenya. [Njenga, Sammy M.] Kenya Govt Med Res Ctr, Eastern & Southern Africa Ctr Int Parasite Contro, Nairobi, Kenya. [Addiss, David G.] Task Force Global Hlth, Children Worms, Decatur, GA USA. RP Harris, JR (reprint author), Ctr Dis Control & Prevent, Parasit Dis Branch, Atlanta, GA 30333 USA. EM ggt5@cdc.gov FU USAID [OG11-12021]; Centers for Disease Control and Prevention FX Funding for this study was obtained from USAID (No. OG11-12021) through an inter-agency agreement with the Centers for Disease Control and Prevention. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 50 TC 5 Z9 5 U1 1 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD MAR PY 2015 VL 9 IS 3 AR e0003590 DI 10.1371/journal.pntd.0003590 PG 11 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CE9YK UT WOS:000352199400058 PM 25763577 ER PT J AU Knauf, S Dahlmann, F Batamuzi, EK Frischmann, S Liu, H AF Knauf, Sascha Dahlmann, Franziska Batamuzi, Emmanuel K. Frischmann, Sieghard Liu, Hsi TI Validation of Serological Tests for the Detection of Antibodies Against Treponema pallidum in Nonhuman Primates SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID CLINICAL SPECIMENS; SCREENING-TESTS; SYPHILIS; YAWS; GUIDELINES; INFECTION; DIAGNOSIS; DISEASE; ASSAYS; TIME AB There is evidence to suggest that the yaws bacterium (Treponema pallidum ssp. pertenue) may exist in non-human primate populations residing in regions where yaws is endemic in humans. Especially in light of the fact that the World Health Organizaiton (WHO) recently launched its second yaws eradication campaign, there is a considerable need for reliable tools to identify treponemal infection in our closest relatives, African monkeys and great apes. It was hypothesized that commercially available serological tests detect simian anti-T. pallidum antibody in serum samples of baboons, with comparable sensitivity and specificity to their results on human sera. Test performances of five different treponemal tests (TTs) and two non-treponemal tests (NTTs) were evaluated using serum samples of 57 naturally T. pallidum-infected olive baboons (Papio anubis) from Lake Manyara National Park in Tanzania. The T. pallidum particle agglutination assay (TP-PA) was used as a gold standard for comparison. In addition, the overall infection status of the animals was used to further validate test performances. For most accurate results, only samples that originated from baboons of known infection status, as verified in a previous study by clinical inspection, PCR and immunohistochemistry, were included. All tests, TTs and NTTs, used in this study were able to reliably detect antibodies against T. pallidum in serum samples of infected baboons. The sensitivity of TTs ranged from 97.7-100%, while specificity was between 88.0-100.0%. The two NTTs detected anti-lipoidal antibodies in serum samples of infected baboons with a sensitivity of 83.3% whereas specificity was 100%. For screening purposes, the TT Espline TP provided the highest sensitivity and specificity and at the same time provided the most suitable format for use in the field. The enzyme immune assay Mastblot TP (IgG), however, could be considered as a confirmatory test. C1 [Knauf, Sascha; Dahlmann, Franziska] German Primate Ctr, Work Grp Neglected Trop Dis, Pathol Unit, Gottingen, Germany. [Batamuzi, Emmanuel K.] Sokoine Univ Agr, Dept Surg & Theriogenol, Fac Vet Med, Morogoro, Tanzania. [Frischmann, Sieghard] Mast Diagnost GmbH, Reinfeld, Germany. [Liu, Hsi] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. RP Knauf, S (reprint author), German Primate Ctr, Work Grp Neglected Trop Dis, Pathol Unit, Gottingen, Germany. EM sknauf@dpz.eu RI Knauf, Sascha/F-1661-2017 OI Knauf, Sascha/0000-0001-5744-4946 FU German Academic Exchange Program [D/06/43974]; Christian Vogel Fond; World Association Zoos and Aquariums [07002]; University of Leipzig; Justus Liebig University of Giessen; Scil animal care company; Telinject; Translogistic; Wuppertal Zoo FX SK received funding and support for the field work at Lake Manyara National Park from German Academic Exchange Program (D/06/43974, https://www.daad.de/de/), Christian Vogel Fond (2006, http://www.gf-primatologie.de/), World Association Zoos and Aquariums (07002, http://www.waza.org/en/site/home), University of Leipzig, Justus Liebig University of Giessen, Scil animal care company, Telinject, Translogistic, and Wuppertal Zoo. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 42 TC 3 Z9 3 U1 3 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD MAR PY 2015 VL 9 IS 3 AR e0003637 DI 10.1371/journal.pntd.0003637 PG 15 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CE9YK UT WOS:000352199400091 PM 25803295 ER PT J AU Dudeck, MA Edwards, JR Allen-Bridson, K Gross, C Malpiedi, PJ Peterson, KD Pollock, DA Weiner, LM Sievert, DM AF Dudeck, Margaret A. Edwards, Jonathan R. Allen-Bridson, Katherine Gross, Cindy Malpiedi, Paul J. Peterson, Kelly D. Pollock, Daniel A. Weiner, Lindsey M. Sievert, Dawn M. TI National Healthcare Safety Network report, data summary for 2013, Device-associated Module SO AMERICAN JOURNAL OF INFECTION CONTROL LA English DT Article C1 [Dudeck, Margaret A.; Edwards, Jonathan R.; Allen-Bridson, Katherine; Gross, Cindy; Malpiedi, Paul J.; Peterson, Kelly D.; Pollock, Daniel A.; Weiner, Lindsey M.; Sievert, Dawn M.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Natl Ctr Emerging Zoonot & Infect Dis, Publ Hlth Serv,US Dept HHS, Atlanta, GA 30329 USA. RP Dudeck, MA (reprint author), Ctr Dis Control & Prevent, Publ Hlth Serv, US Dept HHS, Natl Ctr Emerging Zoonot & Infect Dis, Atlanta, GA 30329 USA. EM mdudeck@cdc.gov FU Intramural CDC HHS [CC999999] NR 10 TC 39 Z9 42 U1 1 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-6553 EI 1527-3296 J9 AM J INFECT CONTROL JI Am. J. Infect. Control PD MAR PY 2015 VL 43 IS 3 BP 206 EP 221 DI 10.1016/j.ajic.2014.11.014 PG 16 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CE8PQ UT WOS:000352106200002 PM 25575913 ER PT J AU Skums, P Artyomenko, A Glebova, O Ramachandran, S Mandoiu, I Campo, DS Dimitrova, Z Zelikovsky, A Khudyakov, Y AF Skums, Pavel Artyomenko, Alexander Glebova, Olga Ramachandran, Sumathi Mandoiu, Ion Campo, David S. Dimitrova, Zoya Zelikovsky, Alex Khudyakov, Yury TI Computational framework for next-generation sequencing of heterogeneous viral populations using combinatorial pooling SO BIOINFORMATICS LA English DT Article ID HEPATITIS-C VIRUS; HIGH-THROUGHPUT; CHRONIC INFECTION; VARIANTS; ERROR; THERAPY; HIV-1 AB Motivation: Next-generation sequencing (NGS) allows for analyzing a large number of viral sequences from infected patients, providing an opportunity to implement large-scale molecular surveillance of viral diseases. However, despite improvements in technology, traditional protocols for NGS of large numbers of samples are still highly cost and labor intensive. One of the possible cost-effective alternatives is combinatorial pooling. Although a number of pooling strategies for consensus sequencing of DNA samples and detection of SNPs have been proposed, these strategies cannot be applied to sequencing of highly heterogeneous viral populations. Results: We developed a cost-effective and reliable protocol for sequencing of viral samples, that combines NGS using barcoding and combinatorial pooling and a computational framework including algorithms for optimal virus-specific pools design and deconvolution of individual samples from sequenced pools. Evaluation of the framework on experimental and simulated data for hepatitis C virus showed that it substantially reduces the sequencing costs and allows deconvolution of viral populations with a high accuracy. C1 [Skums, Pavel; Ramachandran, Sumathi; Campo, David S.; Dimitrova, Zoya; Khudyakov, Yury] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30333 USA. [Artyomenko, Alexander; Glebova, Olga; Zelikovsky, Alex] Georgia State Univ, Dept Comp Sci, Atlanta, GA 30303 USA. [Mandoiu, Ion] Univ Connecticut, Dept Comp Sci & Engn, Storrs, CT USA. RP Skums, P (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30333 USA. EM kki8@cdc.gov; yek0@cdc.gov OI Mandoiu, Ion/0000-0002-4818-0237 NR 32 TC 2 Z9 3 U1 2 U2 9 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1367-4803 EI 1460-2059 J9 BIOINFORMATICS JI Bioinformatics PD MAR 1 PY 2015 VL 31 IS 5 BP 682 EP 690 DI 10.1093/bioinformatics/btu726 PG 9 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Computer Science, Interdisciplinary Applications; Mathematical & Computational Biology; Statistics & Probability SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Computer Science; Mathematical & Computational Biology; Mathematics GA CF0XT UT WOS:000352268500009 PM 25359889 ER PT J AU Villarino, ME Scott, NA Weis, SE Weiner, M Conde, MB Jones, B Nachman, S Oliveira, R Moro, RN Shang, N Goldberg, SV Sterling, TR AF Villarino, M. Elsa Scott, Nigel A. Weis, Stephen E. Weiner, Marc Conde, Marcus B. Jones, Brenda Nachman, Sharon Oliveira, Ricardo Moro, Ruth N. Shang, Nong Goldberg, Stefan V. Sterling, Timothy R. CA Int Maternal Pediat and Adolescent TI Treatment for Preventing Tuberculosis in Children and Adolescents A Randomized Clinical Trial of a 3-Month, 12-Dose Regimen of a Combination of Rifapentine and Isoniazid SO JAMA PEDIATRICS LA English DT Article ID LATENT TUBERCULOSIS; INTERVAL ESTIMATION; INFECTION; PROPORTIONS; CONTACTS; THERAPY AB IMPORTANCE Three months of a once-weekly combination of rifapentine and isoniazid for treatment of latent tuberculosis infection is safe and effective for persons 12 years or older. Published data for children are limited. OBJECTIVES To compare treatment safety and assess noninferiority treatment effectiveness of combination therapy with rifapentine and isoniazid vs 9 months of isoniazid treatment for latent tuberculosis infection in children. DESIGN, SETTING AND PARTICIPANTS A pediatric cohort nested within a randomized, open-label clinical trial conducted from June 11, 2001, through December 17 2010 with follow-up through September 5, 2013, in 29 study sites in the United States Canada, Brazil, Hong Kong (China), and Spain. Participants were children (aged 2-17 years) Who were eligible for treatment of latent tuberculosis infection. IN Twelve once-weekly doses of the combination drugs, given with supervision by a health care professional, for 3 months vs 270 daily doses of isoniazid, without supervision by a health care Professional, for 9 months. MAIN OUTCOMES AND MEASURES We compared rates of treatment discontinuation because of adverse events (AEs), toxicity grades 1 to 4, and deaths from any cause. The equivalence margin for the comparison of AE-related discontinuation rates was 5%. Tuberculosis disease diagnosed within 33 months of enrollment was the main end point for testing effectiveness. The noninferiority margin was 0.75%. RESULTS Of 1058 children enrolled, 905 were eligible for evaluation of effectiveness. Of 471 in the combination-therapy group, 415 (88.1%) completed treatment vs 351 of 434(80.9%) in the isoniazid-only group (P = .003). The 95% Cl for the difference in rates of discontinuation attributed to an AE was -2.6 to 0.1, which was within the equivalence range. In the safety population, 3 of 539 participants (0.6%) who took the combination drugs had a grade 3 AE vs 1 of 493(0.2%) who received isoniazid only. Neither arm had any hepatotoxicity, grade 4 AEs, or treatment-attributed death. None of the 471 in the combination-therapy group developed tuberculosis vs 3 of 434 (cumulative rate, 0.74%) in the isoniazid-only group, for a difference of -0.74% and an upper bound of the 95% Cl of the difference of +0.32%, which met the noninferiority criterion. CONCLUSIONS AND RELEVANCE Treatment with the combination of rifapentine and isoniazid was as effective as isoniazid-only treatment for the prevention of tuberculosis in children aged 2 to 17 years. The combination-therapy group had a higher treatment completion rate than did the isoniazid-only group and was safe. C1 [Villarino, M. Elsa; Scott, Nigel A.; Moro, Ruth N.; Shang, Nong; Goldberg, Stefan V.] Ctr Dis Control & Prevent CDC, Div TB Eliminat, Atlanta, GA 30329 USA. [Scott, Nigel A.; Moro, Ruth N.] CDC Fdn, Atlanta, GA USA. [Weis, Stephen E.] Univ North Texas Hlth Sci Ctr Ft Worth, Dept Med, Ft Worth, TX USA. [Weiner, Marc] Audie L Murphy San Antonio Vet Adm, Med Ctr, Dept Med, San Antonio, TX USA. [Conde, Marcus B.] Univ Fed Rio de Janeiro, Dept Med, Rio De Janeiro, Brazil. [Jones, Brenda] Univ So Calif, Dept Med, Los Angeles, CA USA. [Nachman, Sharon] SUNY Stony Brook, Dept Pediat, Stony Brook, NY USA. [Oliveira, Ricardo] Univ Fed Rio de Janeiro, Inst Pediat, Dept Pediat, Rio De Janeiro, Brazil. [Sterling, Timothy R.] Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37235 USA. RP Moro, RN (reprint author), Ctr Dis Control & Prevent, Div TB Eliminat, Bldg 12,Mail Stop E-10, Atlanta, GA 30329 USA. EM rmoro@cdc.gov RI Conde, Marcus/A-2501-2013; Kam, Kai Man/K-4546-2012; OI Kam, Kai Man/0000-0003-0579-0307; Ocana, Inma/0000-0003-3699-0790; Millet, Joan Pau/0000-0003-0200-2459 FU CDC Foundation FX Sanofi provided the rifapentine for this study and has donated more than $2.5 million to the CDC Foundation to supplement available US federal funding for rifapentine research. NR 34 TC 31 Z9 32 U1 1 U2 3 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6203 EI 2168-6211 J9 JAMA PEDIATR JI JAMA Pediatr. PD MAR PY 2015 VL 169 IS 3 BP 247 EP 255 DI 10.1001/jamapediatrics.2014.3158 PG 9 WC Pediatrics SC Pediatrics GA CF3KR UT WOS:000352447900013 PM 25580725 ER PT J AU Kit, BK Kuklina, E Carroll, MD Ostchega, Y Freedman, DS Ogden, CL AF Kit, Brian K. Kuklina, Elena Carroll, Margaret D. Ostchega, Yechiam Freedman, David S. Ogden, Cynthia L. TI Prevalence of and Trends in Dyslipidemia and Blood Pressure Among US Children and Adolescents, 1999-2012 SO JAMA PEDIATRICS LA English DT Article ID CARDIOVASCULAR RISK-FACTORS; NUTRITION EXAMINATION SURVEY; WHITE COAT HYPERTENSION; UNITED-STATES; NATIONAL-HEALTH; SECULAR TRENDS; SERUM-LIPIDS; CHILDHOOD; ADULTHOOD; OVERWEIGHT AB IMPORTANCE Recent national data suggest there were improvements in serum lipid concentrations among US children and adolescents between 1988 and 2010 but an increase in or stable blood pressure (BP) during a similar period. OBJECTIVE To describe the prevalence of and trends in dyslipidemia and adverse BP among US children and adolescents. DESIGN The National Health and Nutrition Examination Survey, a cross-sectional survey. SETTING Noninstitutionalized US population. PARTICIPANTS Children and adolescents aged 8 to 17 years with measured lipid concentrations (n = 1482) and BP (n = 1665). MAIN OUTCOMES AND MEASURES Adverse concentrations of total cholesterol (TC) (>= 200 mg/dL), high-density lipoprotein cholesterol (HDL-C) (<40 mg/dL), and non-HDL-C (>= 145 mg/dL) (to convert TC, HDL-C, and non-HDL-C to millimoles per liter, multiply by 0.0259) and high or borderline BP were examined. Definitions of BP were informed by the Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents by the National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. Analyses of linear trends in dyslipidemias and BP were conducted overall and separately by sex across 7 periods (1999-2000, 2001-2002, 2003-2004, 2005-2006, 2007-2008, 2009-2010, and 2011-2012). RESULTS In 2011-2012, 20.2% (95% Cl, 16.3-24.6) of youths had an adverse concentration of TC, HDL-C, or non-HDL-C and 11.0% (95% Cl, 8.8-13.4) had either high or borderline BP. The prevalences of adverse concentrations decreased between 1999-2000 and 2011-2012 for TC (10.6% [95% Cl, 8.3-13.2] vs 7.8% [95% Cl, 5.7-10.4]; P = .006), HDL-C (17.9% [95% Cl, 15.0-21.0] vs 12.8% [95% Cl, 9.8-16.2]; P = .003), and non-HDL-C (13.6% [95% Cl, 11.3-16.2] vs 8.4% [95% Cl, 5.9-11.5]; P < .001). There was a decrease in high BP between 1999-2000 (3.0% [95% Cl, 2.0-4.3]) and 2011-2012 (1.6% [95% Cl, 1.0-2.4]) (P = .003). There was no change from 1999-2000 to 2011-2012 in borderline high BP (7.6% [95% Cl, 5.8-9.8] vs 9.4% [95% Cl, 7.2-11.9]; P = .90) or either high or borderline high BP (10.6% [8.4-13.1] vs 11.0% [95% Cl, 8.8-13.4]; P = .26). CONCLUSIONS AND RELEVANCE In 2011-2012, approximately 1 in 5 children and adolescents aged 8 to 17 years had an adverse lipid concentration of TC, HDL-C, or non-HDL-C and slightly more than 1 in 10 had either borderline high or high BP. The prevalence of dyslipidemia modestly decreased between 1999-2000 and 2011-2012, but either high or borderline high BP remained stable. The reasons for these trends require further study. C1 [Kit, Brian K.] US PHS, Rockville, MD USA. [Kit, Brian K.; Carroll, Margaret D.; Ostchega, Yechiam; Ogden, Cynthia L.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Div Hlth & Nutr Examinat Surveys, Hyattsville, MD 20782 USA. [Kuklina, Elena] Natl Ctr Chron Dis Prevent & Hlth Promot, Div Heart Dis & Stroke Prevent, Atlanta, GA USA. [Freedman, David S.] Natl Ctr Chron Dis Prevent & Hlth Promot, Div Nutr Phys Act & Obes, Atlanta, GA USA. RP Kit, BK (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Div Hlth & Nutr Examinat Surveys, 3311 Toledo Rd,Room 4419, Hyattsville, MD 20782 USA. EM igdO@cdc.gov NR 44 TC 37 Z9 37 U1 3 U2 12 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6203 EI 2168-6211 J9 JAMA PEDIATR JI JAMA Pediatr. PD MAR PY 2015 VL 169 IS 3 BP 272 EP 279 DI 10.1001/jamapediatrics.2014.3216 PG 8 WC Pediatrics SC Pediatrics GA CF3KR UT WOS:000352447900016 PM 25599372 ER PT J AU Ayala, C Fang, J Yuan, KM AF Ayala, Carma Fang, Jing Yuan, Keming TI Prevalence of Taking Actions to Control Blood Pressure Among Adults With Self-Reported Hypertension in 18 States and the District of Columbia, 2009 SO JOURNAL OF CLINICAL HYPERTENSION LA English DT Article ID AMERICAN-HEART-ASSOCIATION; FACTOR SURVEILLANCE SYSTEM; UNITED-STATES; PHYSICAL-ACTIVITY; DIETARY PATTERNS; RANDOMIZED-TRIAL; CLINICAL-TRIAL; RISK-FACTORS; HEALTH-CARE; INTERVENTION AB The authors used 2009 Behavioral Risk Factor Surveillance System data to assess the prevalence of taking actions to control hypertension among adults with self-reported hypertension. Differences by descriptive characteristics (sex, age, race/ethnicity, access to health care, medication adherence), presence of other health risk factors (overweight/obesity, smoking, heavy drinking, inadequate fruit/vegetable intake, and physical inactivity), and comorbidities (diabetes, high cholesterol, coronary heart disease, and stroke) were compared. The prevalence of hypertension was 29.6%, and 75.0% of these patients reported taking antihypertensive medications, 73.1% changed eating habits, 72.8% decreased the use of salt, 78.8% reduced alcohol consumption, and 69.9% increased their physical activity. Overall, 87.2% reported taking two or more actions to reduce blood pressure. Patients taking antihypertensive medications were more likely to take two or more actions than their counterparts (90.6% vs 79.4%, P<.01). Those with at least one other health risk factor were 1.85 times as likely to take two or more actions as their counterparts (95% confidence interval, 1.18-2.92 times). More than 80% of hypertensive adults reported taking two or more actions to control blood pressure. The prevalence of taking actions differed significantly by descriptive characteristics, the presence health risk factors, and comorbidities. Published 2015. This article is a U.S. Government work and is in the public domain in the USA. C1 [Ayala, Carma; Fang, Jing; Yuan, Keming] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Ayala, C (reprint author), 4770 Buford Highway NE,MS F72, Atlanta, GA 30341 USA. EM cia1@cdc.gov NR 52 TC 2 Z9 2 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1524-6175 EI 1751-7176 J9 J CLIN HYPERTENS JI J. Clin. Hypertens. PD MAR PY 2015 VL 17 IS 3 BP 172 EP 182 DI 10.1111/jch.12476 PG 11 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA CE9BQ UT WOS:000352138800003 PM 25644363 ER PT J AU Cuthbert, JP Harrison-Felix, C Corrigan, JD Kreider, S Bell, JM Coronado, VG Whiteneck, GG AF Cuthbert, Jeffrey P. Harrison-Felix, Cynthia Corrigan, John D. Kreider, Scott Bell, Jeneita M. Coronado, Victor G. Whiteneck, Gale G. TI Epidemiology of Adults Receiving Acute Inpatient Rehabilitation for a Primary Diagnosis of Traumatic Brain Injury in the United States SO JOURNAL OF HEAD TRAUMA REHABILITATION LA English DT Article DE craniocerebral trauma; outcomes; prevalence; rehabilitation; traumatic brain injury ID SYSTEMS NATIONAL DATABASE; PRACTICAL SCALE; REPRESENTATIVENESS; ORIENTATION; COMA AB Objective: To estimate the overall and by age-group characteristics at admission and discharge from rehabilitation between 2001 and 2010 of all late-teens and adults undergoing inpatient rehabilitation for a primary diagnosis of traumatic brain injury (TBI) in the United States. Design: Secondary data analysis. Setting: Acute inpatient rehabilitation facilities. Participants: Patients aged 16 years and older receiving inpatient rehabilitation for a primary diagnosis of TBI between 2001 and 2010. Main Outcome Measures: Functional independence, level of disability, and living situation. Results: The incidence of TBI by age group found the largest proportion of cases to be aged 80 years and older, with a gradual decline in incidence in the age group of 30 years, at which point there was a slight increase. Injuries resulted predominantly from falls (49.8%) and motor vehicle crashes (40.8%); however, injuries to the youngest individuals were largely from motor vehicle crashes with decreasing rates as age increased, while injuries due to falls rose as age increased, with the oldest age groups most likely to incur a TBI. Preinjury alcohol misuse and substance use were found to occur in 22.9% and 12.2% of the total population, respectively; however, age distributions demonstrated high preinjury use among individuals younger than 50 years (eg, 46.4% and 30.6% for those aged 20 and 29 years, respectively) with decreasing misuse as age increased. Of the total population, 49.2% were retired, 31.1% employed, 14.1% not working, and 5.6% students. Trends by age showed that younger individuals were more likely to be students or employed (eg, 14.5% and 62.0% for those aged 20 and 29 years, respectively), with employment status peaking for those aged 30 to 39 years, and declining to 3.2% for the oldest age group (80 years and older). The trend of person(s) living alone between pre- and postrehabilitation showed the least amount of change for those aged 16 to 19 years with steadily increasing changes as age increased. Similar trends were seen for residence changes pre- and postrehabilitation, with the youngest most likely to return to living at a private residence, and a gradual decrease in return to living at a private residence as age increased. FIM instrument ("FIM") Motor and Cognitive subscale scores demonstrated that younger individuals had lower scores at admission to rehabilitation and higher scores at rehabilitation discharge. Conclusion: This study provides population estimates for all patients 16 years of age and older receiving inpatient rehabilitation for a primary diagnosis of TBI in the United States between 2001 and 2010. A recent trend shows the aging of the inpatient TBI rehabilitation population. Many characteristics important to rehabilitation outcomes are influenced by age, with older individuals trending toward being female, having less severe TBIs, incurring TBIs as a result of falls, but showing less improvement during rehabilitation, greater resulting disability, and more changes in their living situation postrehabilitation. These findings are of particular interest, as the oldest age groups considered in these analyses did not include the baby boom population. C1 [Cuthbert, Jeffrey P.; Harrison-Felix, Cynthia; Kreider, Scott; Whiteneck, Gale G.] Craig Hosp, Res Dept, Englewood, CO 80113 USA. [Corrigan, John D.] Ohio State Univ, Dept Phys Med & Rehabil, Columbus, OH 43210 USA. [Bell, Jeneita M.; Coronado, Victor G.] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA. RP Cuthbert, JP (reprint author), Craig Hosp, Res Dept, 3425 S Clarkson St, Englewood, CO 80113 USA. EM JCuthbert@craighospital.org FU US Department of Health and Human Services (HHS); Centers for Disease Control and Prevention (CDC); US Department of Education, Office of Special Education and Rehabilitative Services, National Institute on Disability and Rehabilitation Research (NIDRR); NIDRR [H133A110006]; Traumatic Brain Injury Model System Centers grant from NIDRR [H133A070029]; NIDRR FX This research was supported by an intra-agency agreement between the US Department of Health and Human Services (HHS), Centers for Disease Control and Prevention (CDC) and the US Department of Education, Office of Special Education and Rehabilitative Services, National Institute on Disability and Rehabilitation Research (NIDRR) with supplemental funding to the NIDRR-funded Traumatic Brain Injury Model Systems National Data and Statistical Center (grant no. H133A110006). It was also supported by a Traumatic Brain Injury Model System Centers grant from NIDRR to Ohio State University (grant no. H133A070029). This article does not reflect the official policy or opinions of the CDC or the US Department of Health and Human Services and does not constitute an endorsement of the individuals or their programs-by CDC, HHS, or other components of the federal government-and none should be inferred. No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit on the authors or on any organization with which the authors are associated. The TBI Model Systems National Database is supported by NIDRR and created and maintained by the TBI Model Systems Centers Program. However, these contents do not necessarily reflect the opinions or views of the TBI Model Systems Centers, NIDRR or the US Department of Education. NR 28 TC 8 Z9 8 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0885-9701 EI 1550-509X J9 J HEAD TRAUMA REHAB JI J. Head Trauma Rehabil. PD MAR-APR PY 2015 VL 30 IS 2 BP 122 EP 135 DI 10.1097/HTR.0000000000000012 PG 14 WC Clinical Neurology; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA CF1MG UT WOS:000352309300015 PM 24495917 ER PT J AU Cogswell, ME Gunn, JP Yuan, KM Park, S Merritt, R AF Cogswell, Mary E. Gunn, Janelle P. Yuan, Keming Park, Sohyun Merritt, Robert TI Sodium and Sugar in Complementary Infant and Toddler Foods Sold in the United States SO PEDIATRICS LA English DT Article ID BLOOD-PRESSURE; NUTRITIONAL CONTENT; BABY FOODS; CHILDHOOD; US; CHILDREN; PREVALENCE; EXPERIENCE; ADULTHOOD; TRACKING AB OBJECTIVES: To evaluate the sodium and sugar content of US commercial infant and toddler foods. METHODS: We used a 2012 nutrient database of 1074 US infant and toddler foods and drinks developed from a commercial database, manufacturer Web sites, and major grocery stores. Products were categorized on the basis of their main ingredients and the US Food and Drug Administration's reference amounts customarily consumed per eating occasion (RACC). Sodium and sugar contents and presence of added sugars were determined. RESULTS: All but 2 of the 657 infant vegetables, dinners, fruits, dry cereals, and ready-to-serve mixed grains and fruits were low sodium (<= 140 mg/RACC). The majority of these foods did not contain added sugars; however, 41 of 79 infant mixed grains and fruits contained >= 1 added sugar, and 35 also contained >35% calories from sugar. Seventy-two percent of 72 toddler dinners were high in sodium content (>210 mg/RACC). Toddler dinners contained an average of 2295 mg of sodium per 1000 kcal (sodium 212 mg/100 g). Savory infant/toddler snacks (n = 34) contained an average of sodium 1382 mg/1000 kcal (sodium 486 mg/100 g); 1 was high sodium. Thirty-two percent of toddler dinners and the majority of toddler cereal bars/breakfast pastries, fruit, and infant/toddler snacks, desserts, and juices contained >= 1 added sugar. CONCLUSIONS: Commercial toddler foods and infant or toddler snacks, desserts, and juice drinks are of potential concern due to sodium or sugar content. Pediatricians should advise parents to look carefully at labels when selecting commercial toddler foods and to limit salty snacks, sweet desserts, and juice drinks. C1 [Cogswell, Mary E.; Gunn, Janelle P.; Yuan, Keming; Merritt, Robert] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Park, Sohyun] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Cogswell, ME (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy NE,Mailstop F72, Atlanta, GA 30341 USA. EM mec0@cdc.gov FU Centers for Disease Control and Prevention FX Supported by the Centers for Disease Control and Prevention. NR 38 TC 8 Z9 8 U1 1 U2 8 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD MAR PY 2015 VL 135 IS 3 BP 416 EP 423 DI 10.1542/peds.2014-3251 PG 8 WC Pediatrics SC Pediatrics GA CF0BD UT WOS:000352206600039 PM 25647681 ER PT J AU Romitti, PA Zhu, Y Puzhankara, S James, KA Nabukera, SK Zamba, GKD Ciafaloni, E Cunniff, C Druschel, CM Mathews, KD Matthews, DJ Meaney, J Andrews, JG Conway, KMC Fox, DJ Street, N Adams, MM Bolen, J AF Romitti, Paul A. Zhu, Yong Puzhankara, Soman James, Katherine A. Nabukera, Sarah K. Zamba, Gideon K. D. Ciafaloni, Emma Cunniff, Christopher Druschel, Charlotte M. Mathews, Katherine D. Matthews, Dennis J. Meaney, John Andrews, Jennifer G. Conway, Kristin M. Caspers Fox, Deborah J. Street, Natalie Adams, Melissa M. Bolen, Julie CA MD STARnet TI Prevalence of Duchenne and Becker Muscular Dystrophies in the United States SO PEDIATRICS LA English DT Article ID HOME NOCTURNAL VENTILATION; NETWORK MD STARNET; NEUROMUSCULAR DISEASES; SURVEILLANCE TRACKING; GENETIC EPIDEMIOLOGY; ALTERNATIVE MEDICINE; POPULATION; DISORDERS; CHILDHOOD; SURVIVAL AB OBJECTIVE: To estimate prevalence of childhood-onset Duchenne and Becker muscular dystrophies (DBMD) in 6 sites in the United States by race/ethnicity and phenotype (Duchenne muscular dystrophy [DMD] or Becker muscular dystrophy [BMD]). METHODS: In 2002, the Centers for Disease Control and Prevention established the Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet) to conduct longitudinal, population-based surveillance and research of DBMD in the United States. Six sites conducted active, multiple-source case finding and record abstraction to identify MD STARnet cases born January 1982 to December 2011. We used cross-sectional analyses to estimate prevalence of DBMD per 10 000 boys, ages 5 to 9 years, for 4 quinquennia (1991-1995, 1996-2000, 2001-2005, and 2006-2010) and prevalence per 10 000 male individuals, ages 5 to 24 years, in 2010. Prevalence was also estimated by race/ethnicity and phenotype. RESULTS: Overall, 649 cases resided in an MD STARnet site during >= 1 quinquennia. Prevalence estimates per 10 000 boys, ages 5 to 9 years, were 1.93, 2.05, 2.04, and 1.51, respectively, for 1991-1995, 1996-2000, 2001-2005, and 2006-2010. Prevalence tended to be higher for Hispanic individuals than non-Hispanic white or black individuals, and higher for DMD than BMD. In 2010, prevalence of DBMD was 1.38 per 10 000 male individuals, ages 5 to 24 years. CONCLUSIONS: We present population-based prevalence estimates for DBMD in 6 US sites. Prevalence differed by race/ethnicity, suggesting potential cultural and socioeconomic influences in the diagnosis of DBMD. Prevalence also was higher for DMD than BMD. Continued longitudinal surveillance will permit us to examine racial/ethnic and socioeconomic differences in treatment and outcomes for MD STARnet cases. C1 [Romitti, Paul A.; Zhu, Yong; Puzhankara, Soman; Nabukera, Sarah K.; Zamba, Gideon K. D.; Mathews, Katherine D.; Conway, Kristin M. Caspers] Univ Iowa, Iowa City, IA 52242 USA. [James, Katherine A.; Matthews, Dennis J.] Univ Colorado, Aurora, CO USA. [Ciafaloni, Emma] Univ Rochester, Rochester, NY USA. [Cunniff, Christopher; Meaney, John; Andrews, Jennifer G.] Univ Arizona, Tucson, AZ USA. [Druschel, Charlotte M.; Fox, Deborah J.] New York State Dept Hlth, Albany, NY USA. [Druschel, Charlotte M.] SUNY, Rensselaer, NY USA. [Street, Natalie; Adams, Melissa M.; Bolen, Julie] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. RP Romitti, PA (reprint author), Univ Iowa, Dept Epidemiol, Coll Publ Hlth, 145 N Riverside Dr,S416 CPHB, Iowa City, IA 52242 USA. EM paul-romitti@uiowa.edu FU Centers for Disease Control and Prevention [U01 DD000189, U01 DD000831] FX Supported by grants (U01 DD000189 and U01 DD000831) from the Centers for Disease Control and Prevention. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 47 TC 10 Z9 10 U1 3 U2 14 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD MAR PY 2015 VL 135 IS 3 BP 513 EP 521 DI 10.1542/peds.2014-2044 PG 9 WC Pediatrics SC Pediatrics GA CF0BD UT WOS:000352206600051 PM 25687144 ER PT J AU Linam, WM Ahmed, M Cope, JR Chu, C Visvesvara, GS da Silva, AJ Qvarnstrom, Y Green, J AF Linam, W. Matthew Ahmed, Mubbasheer Cope, Jennifer R. Chu, Craig Visvesvara, Govinda S. da Silva, Alexandre J. Qvarnstrom, Yvonne Green, Jerril TI Successful Treatment of an Adolescent With Naegleria fowleri Primary Amebic Meningoencephalitis SO PEDIATRICS LA English DT Article ID SEVERE BACTERIAL-MENINGITIS; FREE-LIVING AMEBAS; IN-VITRO; BALAMUTHIA-MANDRILLARIS; AMPHOTERICIN-B; ACANTHAMOEBA SPP.; BRAIN-INJURY; MOUSE MODEL; HYPOTHERMIA; INFECTION AB Naegleria fowleri is a thermophilic, free-living ameba that causes primary amebic meningoencephalitis. The infections are nearly always fatal. We present the third well-documented survivor of this infection in North America. The patient's survival most likely resulted from a variety of factors: early identification and treatment, use of a combination of antimicrobial agents (including miltefosine), and management of elevated intracranial pressure based on the principles of traumatic brain injury. C1 [Linam, W. Matthew] Arkansas Childrens Hosp, Pediat Infect Dis Sect, Little Rock, AR 72202 USA. [Ahmed, Mubbasheer; Chu, Craig; Green, Jerril] Arkansas Childrens Hosp, Pediat Crit Care Sect, Little Rock, AR 72202 USA. [Cope, Jennifer R.; Visvesvara, Govinda S.; da Silva, Alexandre J.; Qvarnstrom, Yvonne] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Linam, WM (reprint author), Arkansas Childrens Hosp, Pediat Infect Dis Sect, 1 Childrens Way,Slot 512-11, Little Rock, AR 72202 USA. EM wlinam@uams.edu FU Intramural CDC HHS [CC999999] NR 24 TC 14 Z9 14 U1 2 U2 22 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD MAR PY 2015 VL 135 IS 3 BP E744 EP E748 DI 10.1542/peds.2014-2292 PG 5 WC Pediatrics SC Pediatrics GA CF0BD UT WOS:000352206600027 PM 25667249 ER PT J AU O'Leary, LA Ortiz, L Montgomery, A Fox, DJ Cunniff, C Ruttenber, M Breen, A Pettygrove, S Klumb, D Druschel, C Frias, JL Robinson, LK Bertrand, J Ferrara, K Kelly, M Gilboa, SM Meaney, FJ AF O'Leary, Leslie A. Ortiz, Linnette Montgomery, April Fox, Deborah J. Cunniff, Christopher Ruttenber, Margaret Breen, April Pettygrove, Sydney Klumb, Don Druschel, Charlotte Frias, Jaime L. Robinson, Luther K. Bertrand, Jacquelyn Ferrara, Kelly Kelly, Maureen Gilboa, Suzanne M. Meaney, F. John CA FASSNetII TI Methods for Surveillance of Fetal Alcohol Syndrome: The Fetal Alcohol Syndrome Surveillance Network II (FASSNetII) - Arizona, Colorado, New York, 2009-2014 SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Article DE birth defects; clinical review; developmental disabilities; fetal alcohol syndrome; population-based surveillance ID GROWTH; LENGTH AB Surveillance of fetal alcohol syndrome (FAS) is important for monitoring the effects of prenatal alcohol exposure and describing the public health burden of this preventable disorder. Building on the infrastructure of the Fetal Alcohol Syndrome Surveillance Network (FASSNet, 1997-2002), in 2009 the Centers for Disease Control and Prevention awarded 5-year cooperative agreements to three states, Arizona, Colorado, and New York, to conduct population-based surveillance of FAS. The Fetal Alcohol Syndrome Surveillance Network II (FASSNetII, 2009-2014) developed a surveillance case definition based on three clinical criteria: characteristic facial features, central nervous system abnormalities, and growth deficiency. FASSNetII modified the FASSNet methods in three important ways: (1) estimation of a period prevalence rather than birth prevalence; (2) surveillance of FAS among school-age children (ages 7-9 years) to better document the central nervous system abnormalities that are not apparent at birth or during infancy; and (3) implementation of an expert clinical review of abstracted data for probable and confirmed cases classified through a computerized algorithm. FASSNetII abstracted data from multiple sources including birth records, medical records from child development centers or other specialty clinics, and administrative databases such as hospital discharge and Medicaid. One challenge of FASSNetII was its limited access to non-medical records. The FAS prevalence that could be estimated was that of the population identified through an encounter with the healthcare system. Clinical and public health programs that identify children affected by FAS provide critical information for targeting preventive, medical and educational services in this vulnerable population. Birth Defects Research (Part A) 103:196-202, 2015. (c) 2015 Wiley Periodicals, Inc. C1 [O'Leary, Leslie A.; Frias, Jaime L.; Bertrand, Jacquelyn; Gilboa, Suzanne M.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Ortiz, Linnette; Cunniff, Christopher; Ferrara, Kelly; Kelly, Maureen; Meaney, F. John] Univ Arizona, Dept Pediat, Tucson, AZ 85721 USA. [Montgomery, April; Ruttenber, Margaret] Colorado Dept Publ Hlth & Environm, Colorado Responds Children Special Needs, Denver, CO USA. [Fox, Deborah J.; Druschel, Charlotte] New York State Dept Hlth, Congenital Malformat Registry, Albany, NY USA. [Breen, April] New York State Dept Hlth, Western Reg Off, Buffalo, NY USA. [Pettygrove, Sydney] Univ Arizona, Coll Publ Hlth, Tucson, AZ USA. [Klumb, Don] Sewall Child Dev Ctr, Denver, CO USA. [Frias, Jaime L.] McKing Consulting Corp, Fairfax, VA USA. [Robinson, Luther K.] Women & Childrens Hosp Buffalo, Buffalo, NY USA. RP O'Leary, LA (reprint author), Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS E-86, Atlanta, GA 30333 USA. EM lao9@cdc.gov FU FOA from the National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention [DD09-910] FX This work was supported through a cooperative agreement under FOA #DD09-910 from the National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention. NR 19 TC 2 Z9 2 U1 1 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD MAR PY 2015 VL 103 IS 3 BP 196 EP 202 DI 10.1002/bdra.23335 PG 7 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA CE2YM UT WOS:000351688500004 PM 25761572 ER PT J AU Marrone, M Schilsky, RL Liu, G Khoury, MJ Freedman, AN AF Marrone, Michael Schilsky, Richard L. Liu, Geoff Khoury, Muin J. Freedman, Andrew N. TI Opportunities for Translational Epidemiology: The Important Role of Observational Studies to Advance Precision Oncology SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Article ID THIOPURINE METHYLTRANSFERASE ACTIVITY; METASTATIC COLORECTAL-CANCER; HUMAN-BREAST CANCER; CHILDHOOD LEUKEMIA; CLINICAL-TRIALS; NEU ONCOGENE; PHARMACOGENETICS; 6-MERCAPTOPURINE; CETUXIMAB; THERAPY AB Within current oncology practice, several genomic applications are being used to inform treatment decisions with molecularly targeted therapies in breast, lung, colorectal, melanoma, and other cancers. This commentary introduces a conceptual framework connecting the full spectrum of biomedical research disciplines, including fundamental laboratory research, clinical trials, and observational studies in the translation of genomic applications into clinical practice. The conceptual framework illustrates the contribution that well-designed observational epidemiologic studies provide to the successful translation of these applications, and characterizes the role observational epidemiology plays in driving the dynamic and iterative bench-to-bedside, and bedside-to-bench translation continuum. We also discuss how the principles of this conceptual model, emphasizing integration of multidisciplinary research, can be applied to the evolving paradigm in "precision oncology" focusing on multiplex tumor sequencing, and we identify opportunities for observational studies to contribute to the successful and efficient translation of this paradigm. (c) 2015 AACR. C1 [Marrone, Michael; Khoury, Muin J.; Freedman, Andrew N.] NCI, Epidemiol & Genom Res Program, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. [Schilsky, Richard L.] Amer Soc Clin Oncol, Alexandria, VA USA. [Liu, Geoff] Princess Margaret Hosp, Div Med Oncol, Univ Hlth Network, Toronto, ON M4X 1K9, Canada. [Khoury, Muin J.] Ctr Dis Control & Prevent, Off Publ Hlth Gen, Atlanta, GA USA. RP Freedman, AN (reprint author), NCI, Clin & Translat Epidemiol Branch, Epidemiol & Genom Res Program, Div Canc Control & Populat Sci, 9609 Med Ctr Dr,Rm4E226 MSC 9762, Bethesda, MD 20892 USA. EM andrew_freedman@nih.gov RI Liu, Geoffrey/N-4421-2016 FU Intramural CDC HHS [CC999999]; Intramural NIH HHS [Z99 CA999999] NR 38 TC 3 Z9 3 U1 0 U2 4 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1055-9965 EI 1538-7755 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD MAR PY 2015 VL 24 IS 3 BP 484 EP 489 DI 10.1158/1055-9965.EPI-14-1086 PG 6 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA CE6NC UT WOS:000351953100002 PM 25750251 ER PT J AU Ryan, U Paparini, A Tong, KS Yang, RC Gibson-Kueh, S O'Hara, A Lymbery, A Xiao, LH AF Ryan, Una Paparini, Andrea Tong, Kaising Yang, Rongchang Gibson-Kueh, Susan O'Hara, Amanda Lymbery, Alan Xiao, Lihua TI Cryptosporidium huwi n. sp (Apicomplexa: Eimeriidae) from the guppy (Poecilia reticulata) SO EXPERIMENTAL PARASITOLOGY LA English DT Article DE Cryptosporidium huwi n. sp; Morphology; Genetic characterization; 18S rRNA; Actin gene; Phylogeny ID MARINE FISH; IDENTIFICATION; GENOTYPES; SAMPLES AB The morphological, biological, and molecular characteristics of Cryptosporidium piscine genotype 1 from the guppy (Poecilia reticulata) are described, and the species name Cryptosporidium huwi n. sp. is proposed to reflect its genetic and biological differences from gastric and intestinal Cryptosporidium species. Oocysts of Cryptosporidium huwi n. sp. over-lap in size with Cryptosporidium molnari, measuring approximately 4.4-4.9 mu m (mean 4.6) by 4.0-4.8 gm (mean 4.4 mu m) with a length to width ratio of 1.04 (0.92-1.35) (n = 50). Similar to Cryptosporidium molnari, Cryptosporidium huwi n. sp. was identified in the stomach only and clusters of oogonial and sporogonial stages were identified deep within the epithelium. However, phylogenetic analysis of 18S rRNA sequences indicated that Cryptosporidium huwi n. sp. exhibited 8.5-9.2% and 3.5% genetic distance from Cryptosporidium molnari isolates and. piscine genotype 7 respectively. At the actin locus, the genetic distance between Cryptosporidium howl n. sp. and Cryptosporidium molnari was 16.6%. The genetic distance between Cryptosporidium huwi n. sp. and other Cryptosporidium species at the 18S locus was 13.2%-17% and at the actin locus was 18.9%-26.3%. Therefore Cryptosporidium huwi n. sp. is genetically distinct from previously described Cryptosporidium species. (C) 2015 Elsevier Inc. All rights reserved. C1 [Ryan, Una; Paparini, Andrea; Tong, Kaising; Yang, Rongchang; Gibson-Kueh, Susan; O'Hara, Amanda; Lymbery, Alan] Murdoch Univ, Sch Vet & Life Sci, Perth, WA 6150, Australia. [Xiao, Lihua] US Dept HHS, Ctr Dis Control & Prevent, Publ Hlth Serv, Atlanta, GA USA. RP Ryan, U (reprint author), Murdoch Univ, Sch Vet & Life Sci, Perth, WA 6150, Australia. EM una.ryan@murdoch.edu.au RI Xiao, Lihua/B-1704-2013; OI Xiao, Lihua/0000-0001-8532-2727; Lymbery, Alan/0000-0002-0542-3446 NR 20 TC 14 Z9 15 U1 1 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0014-4894 EI 1090-2449 J9 EXP PARASITOL JI Exp. Parasitol. PD MAR PY 2015 VL 150 BP 31 EP 35 DI 10.1016/j.exppara.2015.01.009 PG 5 WC Parasitology SC Parasitology GA CE8UZ UT WOS:000352120900005 PM 25637783 ER PT J AU Ceballos, DM Beaucham, CC Kurtz, K Musolin, K AF Ceballos, Diana M. Beaucham, Catherine C. Kurtz, Kristine Musolin, Kristin TI Assessing occupational exposure to sea lamprey pesticides SO INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH LA English DT Article DE Sea lampreys; Pesticides; TFM; Bayluscide; Wipe sampling; River application; Dermal exposure; Biological station; Lampricides ID ENVIRONMENTAL FATE AB Background: Sea lampreys are parasitic fish found in lakes of the United States and Canada. Sea lamprey is controlled through manual application of the pesticides 3-trifluoromethyl-4-nitrophenol (TFM) and Bayluscide TM into streams and tributaries. 3-Trifluoromethyl-4-nitrophenol may cause irritation and central nervous system depression and Bayluscide may cause irritation, dermatitis, blisters, cracking, edema, and allergic skin reactions. Objectives: To assess occupational exposures to sea lamprey pesticides. Methods: We developed a wipe method for evaluating surface and skin contamination with these pesticides. This method was field tested at a biological field station and at a pesticide river application. We also evaluated exposures using control banding tools. Results: We verified TFM surface contamination at the biological station. At the river application, we found surfaces and worker's skin contaminated with pesticides. Conclusion: We recommended minimizing exposures by implementing engineering controls and improved use of personal protective equipment. C1 [Ceballos, Diana M.; Beaucham, Catherine C.; Musolin, Kristin] NIOSH, Cincinnati, OH 45226 USA. [Kurtz, Kristine] Bur Veritas North Amer Inc, Hlth Safety & Environm Serv, Costa Mesa, CA USA. RP Ceballos, DM (reprint author), NIOSH, DSHEFS HETAB, 1090 Tusculum Ave,MS 11, Cincinnati, OH 45226 USA. EM DCeballos@cdc.gov FU NIOSH Health Hazard Evaluation work FX This work was part of the NIOSH Health Hazard Evaluation work, funded internally as a Program. NR 21 TC 0 Z9 0 U1 0 U2 9 PU MANEY PUBLISHING PI LEEDS PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND SN 1077-3525 EI 2049-3967 J9 INT J OCCUP ENV HEAL JI Int. J. Occup. Environ. Health PD MAR PY 2015 VL 21 IS 2 BP 151 EP 160 DI 10.1179/2049396715Y.0000000002 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CE5KZ UT WOS:000351874800006 PM 25730600 ER PT J AU Gajadeera, C Willby, MJ Green, KD Shaul, P Fridman, M Garneau-Tsodikova, S Posey, JE Tsodikov, OV AF Gajadeera, Chathurada Willby, Melisa J. Green, Keith D. Shaul, Pazit Fridman, Micha Garneau-Tsodikova, Sylvie Posey, James E. Tsodikov, Oleg V. TI Antimycobacterial activity of DNA intercalator inhibitors of Mycobacterium tuberculosis primase DnaG SO JOURNAL OF ANTIBIOTICS LA English DT Article ID TARGETED CHEMOTHERAPY; CANCER-CELLS; IN-VITRO; RESISTANT; SMEGMATIS; DOXORUBICIN; MUTANTS; REPLICATION; DISCOVERY; GYRASE AB Owing to the rise in drug resistance in tuberculosis combined with the global spread of its causative pathogen, Mycobacterium tuberculosis (Mtb), innovative anti mycobacterial agents are urgently needed. Recently, we developed a novel primasepyrophosphatase assay and used it to discover inhibitors of an essential Mtb enzyme, primase DnaG (Mtb DnaG), a promising and unexplored potential target for novel antituberculosis chemotherapeutics. Doxorubicin, an anthracycline antibiotic used as an anticancer drug, was found to be a potent inhibitor of Mtb DnaG. In this study, we investigated both inhibition of Mtb DnaG and the inhibitory activity against in vitro growth of Mtb and M. smegmatis (Msm) by other anthracyclines, daunorubicin and idarubicin, as well as by less cytotoxic DNA intercalators: aloe-emodin, rhein and a mitoxantrone derivative. Generally, low-mu M inhibition of Mtb DnaG by the anthracyclines was correlated with their low-mu M minimum inhibitory concentrations. Aloe-emodin displayed threefold weaker potency than doxorubicin against Mtb DnaG and similar inhibition of Msm (but not Mtb) in the mid-mu M range, whereas rhein (a close analog of aloe-emodin) and a di-glucosylated mitoxantrone derivative did not show significant inhibition of Mtb DnaG or antimycobacterial activity. Taken together, these observations strongly suggest that several clinically used anthracyclines and aloe-emodin target mycobacterial primase, setting the stage for a more extensive exploration of this enzyme as an antibacterial target. C1 [Gajadeera, Chathurada; Green, Keith D.; Garneau-Tsodikova, Sylvie; Tsodikov, Oleg V.] Univ Kentucky, Dept Pharmaceut Sci, Lexington, KY 40536 USA. [Willby, Melisa J.; Posey, James E.] Ctr Dis Control & Prevent, Div TB Eliminat, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. [Shaul, Pazit; Fridman, Micha] Tel Aviv Univ, Sch Chem, IL-69978 Tel Aviv, Israel. RP Garneau-Tsodikova, S (reprint author), Univ Kentucky, Dept Pharmaceut Sci, BioPharm Complex,Room 423,789 South Limestone St, Lexington, KY 40536 USA. EM sylviegtsodikova@uky.edu; hzp9@cdc.gov; oleg.tsodikov@uky.edu FU College of Pharmacy at the University of Kentucky; Israel Science Foundation (ISF) [58/10] FX This work was supported by startup funds from the College of Pharmacy at the University of Kentucky (to SG-T and OVT) and by a grant from the Israel Science Foundation (ISF, grant 58/10 to MF). We thank Dr Caixia Hou for helping with purification of Mtb DnaG. NR 35 TC 5 Z9 5 U1 4 U2 19 PU JAPAN ANTIBIOTICS RESEARCH ASSOC PI TOKYO PA 2 20 8 KAMIOSAKI SHINAGAWA KU, TOKYO, 141, JAPAN SN 0021-8820 J9 J ANTIBIOT JI J. Antibiot. PD MAR PY 2015 VL 68 IS 3 BP 153 EP 157 DI 10.1038/ja.2014.131 PG 5 WC Biotechnology & Applied Microbiology; Immunology; Microbiology; Pharmacology & Pharmacy SC Biotechnology & Applied Microbiology; Immunology; Microbiology; Pharmacology & Pharmacy GA CE5IJ UT WOS:000351864700003 PM 25248725 ER PT J AU Ford, ES Cunningham, TJ Giles, WH Croft, JB AF Ford, Earl S. Cunningham, Timothy J. Giles, Wayne H. Croft, Janet B. TI Trends in insomnia and excessive daytime sleepiness among US adults from 2002 to 2012 SO SLEEP MEDICINE LA English DT Article DE Arthralgia; Diabetes; Health surveys; Insomnia; Population surveillance; Trends ID POPULATION; MORTALITY; PREVALENCE; DURATION; RISK; SYMPTOMS; DISEASE; COHORT; WOMEN; MEN AB Objective: Insomnia is a prevalent disorder in the United States and elsewhere. It has been associated with a range of somatic and psychiatric conditions, and adversely affects quality of life, productivity at work, and school performance. The objective of this study was to examine the trend in self-reported insomnia and excessive daytime sleepiness among US adults. Methods: We used data of participants aged >= 18 years from the National Health Interview Survey for the years 2002 (30,970 participants), 2007 (23,344 participants), and 2012 (34,509 participants). Results: The unadjusted prevalence of insomnia or trouble sleeping increased from 17.5% (representing 37.5 million adults) in 2002 to 19.2% (representing 46.2 million adults) in 2012 (relative increase: +8.0%) (P trend <0.001). The age-adjusted prevalence increased from 17.4% to 18.8%. Significant increases were present among participants aged 18-24, 25-34, 55-64, and 65-74 years, men, women, whites, Hispanics, participants with diabetes, and participants with joint pain. Large relative increases occurred among participants aged 18-24 years (+30.9%) and participants with diabetes (+27.0%). The age-adjusted percentage of participants who reported regularly having excessive daytime sleepiness increased from 9.8% to 12.7% (P trend <0.001). Significant increases were present in most demographic groups. The largest relative increase was among participants aged 25-34 years (+49%). Increases were also found among participants with hypertension, chronic obstructive pulmonary disease, asthma, and joint pain. Conclusions: Given the deleterious effects of insomnia on health and performance, the increasing prevalence of insomnia and excessive daytime sleepiness among US adults is a potentially troubling development. Published by Elsevier B.V. C1 [Ford, Earl S.; Cunningham, Timothy J.; Giles, Wayne H.; Croft, Janet B.] Ctr Dis Control & Prevent, Div Populat Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Ford, ES (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway,MS F78, Atlanta, GA 30341 USA. EM eford@cdc.gov FU Intramural CDC HHS [CC999999] NR 36 TC 16 Z9 18 U1 1 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1389-9457 EI 1878-5506 J9 SLEEP MED JI Sleep Med. PD MAR PY 2015 VL 16 IS 3 BP 372 EP 378 DI 10.1016/j.sleep.2014.12.008 PG 7 WC Clinical Neurology SC Neurosciences & Neurology GA CE3GJ UT WOS:000351714400013 PM 25747141 ER PT J AU Kahler, AM Johnson, TB Hahn, D Narayanan, J Derado, G Hill, VR AF Kahler, Amy M. Johnson, Trisha B. Hahn, Donghyun Narayanan, Jothikumar Derado, Gordana Hill, Vincent R. TI Evaluation of an Ultrafiltration-Based Procedure for Simultaneous Recovery of Diverse Microbes in Source Waters SO WATER LA English DT Article ID HOLLOW-FIBER ULTRAFILTRATION; CRYPTOSPORIDIUM-PARVUM OOCYSTS; DEAD-END ULTRAFILTRATION; SURFACE-WATER; IMMUNOMAGNETIC SEPARATION; DRINKING-WATER; SAMPLES; VIRUSES; ENTEROVIRUSES; FILTER AB In this study, hollow-fiber ultrafiltration (UF) was assessed for recovery of Escherichia coli, Clostridium perfringens spores, Cryptosporidium parvum oocysts, echovirus 1, and bacteriophages MS2 and phi X174 from ground and surface waters. Microbes were seeded into twenty-two 50-L water samples that were collected from the Southeastern United States and concentrated to ~500 mL by UF. Secondary concentration was performed for C. parvum by centrifugation followed by immunomagnetic separation. Secondary concentration for viruses was performed using centrifugal ultrafilters or polyethylene glycol precipitation. Nine water quality parameters were measured in each water sample to determine whether water quality data correlated with UF and secondary concentration recovery efficiencies. Average UF recovery efficiencies were 66%-95% for the six enteric microbes. Average recovery efficiencies for the secondary concentration methods were 35%-95% for C. parvum and the viruses. Overall, measured water quality parameters were not significantly associated with UF recovery efficiencies. However, recovery of phi X174 was negatively correlated with turbidity. The recovery data demonstrate that UF can be an effective method for concentrating diverse microbes from ground and surface waters. This study highlights the utility of tangential-flow hollow fiber ultrafiltration for recovery of bacteria, viruses, and parasites from large volume environmental water samples. C1 [Kahler, Amy M.; Narayanan, Jothikumar; Derado, Gordana; Hill, Vincent R.] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30329 USA. [Johnson, Trisha B.; Hahn, Donghyun] Atlanta Res & Educ Fdn, Decatur, GA 30033 USA. RP Hill, VR (reprint author), Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30329 USA. EM akahler@cdc.gov; trisha.johnson@gmail.com; dunhahn@gmail.com; jin2@cdc.gov; uwx8@cdc.gov; vhill@cdc.gov FU CDC Office of Public Health and Preparedness and Response FX We thank Cobb-County Marietta, Lawrenceville, and Jefferson City water utilities for collecting water samples. A portion of the funding for this study was provided by CDC Office of Public Health and Preparedness and Response. Use of trade names and commercial sources is for identification only and does not imply endorsement by the Centers for Disease Control and Prevention (CDC) or the U.S. Department of Health and Human Services. The findings and conclusions in this report are those of the authors and do not necessarily represent those of the CDC. NR 32 TC 3 Z9 3 U1 3 U2 15 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2073-4441 J9 WATER-SUI JI Water PD MAR PY 2015 VL 7 IS 3 BP 1202 EP 1216 DI 10.3390/w7031202 PG 15 WC Water Resources SC Water Resources GA CF1DP UT WOS:000352284200020 PM 26530003 ER PT J AU Loprinzi, PD Ford, ES AF Loprinzi, Paul D. Ford, Earl S. TI THE ASSOCIATION BETWEEN OBJECTIVELY MEASURED SEDENTARY BEHAVIOR AND RED BLOOD CELL DISTRIBUTION WIDTH IN A NATIONAL SAMPLE OF US ADULTS SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article ID UNITED-STATES; FAILURE; DISEASE; HEART C1 [Loprinzi, Paul D.] Univ Mississippi, Sch Appl Sci, Ctr Hlth Behav Res, Dept Hlth Exercise Sci & Recreat Management, University, MS 38677 USA. [Ford, Earl S.] Ctr Dis Control & Prevent, Div Populat Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Loprinzi, PD (reprint author), Univ Mississippi, Sch Appl Sci, Ctr Hlth Behav Res, Dept Hlth Exercise Sci & Recreat Management, University, MS 38677 USA. EM pdloprin@olemiss.edu FU Intramural CDC HHS [CC999999] NR 13 TC 6 Z9 6 U1 0 U2 4 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 EI 1476-6256 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD MAR 1 PY 2015 VL 181 IS 5 BP 357 EP 359 DI 10.1093/aje/kwv003 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CE0PR UT WOS:000351507100010 PM 25693774 ER PT J AU Spitz, MR Lam, TK Schully, SD Khoury, MJ AF Spitz, Margaret R. Lam, Tram Kim Schully, Sheri D. Khoury, Muin J. TI RE: "THE NEXT GENERATION OF LARGE-SCALE EPIDEMIOLOGIC RESEARCH: IMPLICATIONS FOR TRAINING CANCER EPIDEMIOLOGISTS" REPLY SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Letter C1 [Spitz, Margaret R.] Baylor Coll Med, Dan L Duncan Canc Ctr, Houston, TX 77030 USA. [Lam, Tram Kim; Schully, Sheri D.; Khoury, Muin J.] NCI, Epidemiol & Genom Res Program, Div Canc Control & Populat Sci, NIH, Bethesda, MD 20892 USA. [Khoury, Muin J.] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA USA. RP Spitz, MR (reprint author), Baylor Coll Med, Dan L Duncan Canc Ctr, Houston, TX 77030 USA. EM spitz@bcm.edu NR 6 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 EI 1476-6256 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD MAR 1 PY 2015 VL 181 IS 5 BP 361 EP 361 DI 10.1093/aje/kwv019 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CE0PR UT WOS:000351507100012 PM 25698647 ER PT J AU Rechtman, L Jordan, H Wagner, L Horton, DK Kaye, W AF Rechtman, Lindsay Jordan, Heather Wagner, Laurie Horton, D. Kevin Kaye, Wendy TI Racial and ethnic differences among amyotrophic lateral sclerosis cases in the United States SO AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION LA English DT Article DE Amyotrophic lateral sclerosis; motor neuron disease; epidemiology; incidence studies; race ID MOTOR-NEURON DISEASE; HONG-KONG; POPULATION; ALS; EPIDEMIOLOGY; HEALTH AB Our objective was to describe racial and ethnic differences of amyotrophic lateral sclerosis (ALS) in distinct geographic locations around the United States (U.S.). ALS cases for the period 2009-2011 were identified using active case surveillance in three states and eight metropolitan areas. Of the 5883 unique ALS cases identified, 74.8% were white, 9.3% were African-American/black, 3.6% were Asian, 12.0% were an unknown race, and 0.3% were marked as some other race. For ethnicity, 77.5% were defined as non-Hispanic, 10.8% Hispanic, and 11.7% were of unknown ethnicity. The overall crude average annual incidence rate was 1.52 per 100,000 person-years and the rate differed by race and ethnicity. The overall age-adjusted average annual incidence rate was 1.44 per 100,000 person-years and the age-adjusted average incidence rates also differed by race and ethnicity. Racial differences were also found in payer type, time from symptom onset to diagnosis, reported El Escorial criteria, and age at diagnosis. In conclusion, calculated incidence rates demonstrate that ALS occurs less frequently in African-American/blacks and Asians compared to whites, and less frequently in Hispanics compared to non-Hispanics in the U.S. A more precise understanding of racial and ethnic variations in ALS may help to reveal candidates for further studies of disease etiology and disease progression. C1 [Rechtman, Lindsay; Jordan, Heather; Wagner, Laurie; Kaye, Wendy] McKing Consulting Corp, Atlanta, GA USA. [Horton, D. Kevin] Agcy Tox Subst & Dis Registry, Atlanta, GA USA. RP Rechtman, L (reprint author), McKing Consulting Corp, 2900 Chamblee Tucker Rd,Bldg 10,Suite 100, Atlanta, GA 30341 USA. EM lrechtman@mcking.com FU McKing Consulting Corporation - Agency for Toxic Substances and Disease Registry FX This project was funded by McKing Consulting Corporation through two contracts funded by the Agency for Toxic Substances and Disease Registry. NR 26 TC 5 Z9 5 U1 0 U2 1 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 2167-8421 EI 2167-9223 J9 AMYOTROPH LAT SCL FR JI Amyotroph. Lateral Scher. Frontotemp. Degenerat. PD MAR PY 2015 VL 16 IS 1-2 BP 65 EP 71 DI 10.3109/21678421.2014.971813 PG 7 WC Clinical Neurology SC Neurosciences & Neurology GA CE0WV UT WOS:000351531900011 PM 25482100 ER PT J AU Sodha, SV Dietz, V AF Sodha, S. V. Dietz, V. TI Strengthening routine immunization systems to improve global vaccination coverage SO BRITISH MEDICAL BULLETIN LA English DT Article DE immunization; vaccination; routine immunization; Expanded Programme on Immunization; vaccination coverage; global health ID REACHING EVERY DISTRICT; MIDDLE-INCOME COUNTRIES; EXPANDED PROGRAM; HEALTH-SERVICES; PUBLISHED LITERATURE; INTEGRATED DELIVERY; RED APPROACH; INTERVENTIONS; ERADICATION; CHILDREN AB Background: Global coverage with the third dose of diphtheria-tetanus-pertussis vaccine among children under 1 year of age stagnated at similar to 83-84% during 2008-13. Sources of data: Annual World Health Organization and UNICEF-derived national vaccination coverage estimates. Areas of agreement: Incomplete vaccination is associated with poor socioeconomic status, lower education, non-use of maternal-child health services, living in conflict-affected areas, missed immunization opportunities and cancelled vaccination sessions. Areas of controversy: Vaccination platforms must expand to include older ages including the second year of life. Immunization programmes, including eradication and elimination initiatives such as those for polio and measles, must integrate within the broader health system. Growing points: The Global Vaccine Action Plan (GVAP) 2011-20 is a framework for strengthening immunization systems, emphasizing country ownership, shared responsibility, equity, integration, sustainability and innovation. Areas timely for developing research: Immunization programmes should identify, monitor and evaluate gaps and interventions within the GVAP framework. C1 [Sodha, S. V.; Dietz, V.] Ctr Dis Control & Prevent CDC, Global Immunizat Div, Atlanta, GA 30333 USA. RP Sodha, SV (reprint author), Ctr Dis Control & Prevent CDC, Global Immunizat Div, 1600 Clifton Rd,MS A-04, Atlanta, GA 30333 USA. EM ssodha@cdc.gov NR 36 TC 6 Z9 6 U1 1 U2 10 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0007-1420 EI 1471-8391 J9 BRIT MED BULL JI Br. Med. Bull. PD MAR PY 2015 VL 113 IS 1 BP 5 EP 14 DI 10.1093/bmb/ldv001 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA CE0RJ UT WOS:000351512300002 PM 25649959 ER PT J AU Layfield, C Rose, J Alford, A Snyder, SR Apple, FS Chowdhury, FM Kontos, MC Newby, LK Storrow, AB Tanasijevic, M Leibach, E Liebow, EB Christenson, RH AF Layfield, Christopher Rose, John Alford, Aaron Snyder, Susan R. Apple, Fred S. Chowdhury, Farah M. Kontos, Michael C. Newby, L. Kristin Storrow, Alan B. Tanasijevic, Milenko Leibach, Elizabeth Liebow, Edward B. Christenson, Robert H. TI Effectiveness of practices for improving the diagnostic accuracy of Non ST Elevation Myocardial Infarction in the Emergency Department: A Laboratory Medicine Best Practices (TM) systematic review SO CLINICAL BIOCHEMISTRY LA English DT Review DE Acute coronary syndrome; Cardiac troponin; Non-ST-segment elevation; Myocardial infarction ID POINT-OF-CARE; ACUTE CORONARY SYNDROMES; CARDIAC TROPONIN ASSAYS; CHEST-PAIN PATIENTS; AMERICAN-HEART-ASSOCIATION; I ASSAY; UNIVERSAL DEFINITION; 99TH PERCENTILE; RAPID DIAGNOSIS; WHOLE-BLOOD AB Objectives: This article is a systematic review of the effectiveness of four practices (assay selection, decision point cardiac troponin (cTn) threshold selection, serial testing, and point of care testing) for improving the diagnostic accuracy Non-ST-Segment Elevation Myocardial Infarction (NSTEMI) in the Emergency Department. Design and methods: The CDC-funded Laboratory Medicine Best Practices (LMBP) Initiative systematic review method for quality improvement practices was used. Results: The current ACC/AHA guidelines recommend using cardiac troponin assays with a 99th percentile upper reference limit (URL) diagnostic threshold to diagnose NSTEMI. The evidence in this systematic review indicates that contemporary sensitive cTn assays meet the assay profile requirements (sensitivity, specificity, PPV, and NPV) to more accurately diagnose NSTEMI than alternate tests. Additional biomarkers did not increase diagnostic effectiveness of cTn assays. Sensitivity, specificity, and NPV were consistently high and low PPV improved with serial sampling. Evidence for use of point of care cTn testing was insufficient to make recommendation, though some evidence suggests that use may result in reduction to patient length of stay and costs. Conclusions: Based on the review of and the LMBP(TM) A-6 Method criteria, we recommend the use of cardiac troponin assays without additional biomarkers using the 99th percentile URL as the clinical diagnostic threshold for the diagnosis of NSTEMI. We recommend serial sampling with one sample at presentation and at least one additional second sample taken at least 6 h later to identify a rise or fall in the troponin level. No recommendation is made either for or against the use of point of care tests. Disclaimer: The findings and conclusions in this article are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention/the Agency for Toxic Substances and Disease Registry (CDC/ATSDR). (C) 2015 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. C1 [Layfield, Christopher; Rose, John; Alford, Aaron] Battelle Mem Inst, Baltimore, MD 21209 USA. [Apple, Fred S.] Hennepin Cty Med Ctr, Minneapolis, MN 55415 USA. [Apple, Fred S.] Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA. [Chowdhury, Farah M.; Leibach, Elizabeth] Ctr Dis Control & Prevent CDC, Atlanta, GA USA. [Kontos, Michael C.] Virginia Commonwealth Univ, Med Ctr, Richmond, VA 23284 USA. [Newby, L. Kristin] Duke Univ, Med Ctr, Durham, NC 27706 USA. [Storrow, Alan B.] Vanderbilt Univ, Med Ctr, Nashville, TN USA. [Tanasijevic, Milenko] Brigham & Womens Hosp, Boston, MA 02115 USA. [Tanasijevic, Milenko] Harvard Univ, Sch Med, Cambridge, MA 02138 USA. [Christenson, Robert H.] Univ Maryland, Sch Med, College Pk, MD USA. RP Layfield, C (reprint author), Battelle Mem Inst, 6115 Falls Rd,Suite 200, Baltimore, MD 21209 USA. EM layfieldc@battelle.org FU CDC [SP0700-00-D-3180] FX CDC funding for the Laboratory Medicine Best Practices Initiative to Battelle Centers for Public Health Research and Evaluation under contract No. SP0700-00-D-3180, Delivery Order 0723. NR 62 TC 5 Z9 5 U1 0 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0009-9120 EI 1873-2933 J9 CLIN BIOCHEM JI Clin. Biochem. PD MAR PY 2015 VL 48 IS 4-5 BP 204 EP 212 DI 10.1016/j.clinbiochem.2015.01.014 PG 9 WC Medical Laboratory Technology SC Medical Laboratory Technology GA CD3YE UT WOS:000351018900003 PM 25661303 ER PT J AU Loharikar, A Newton, AE Stroika, S Freeman, M Greene, KD Parsons, MB Bopp, C Talkington, D Mintz, ED Mahon, BE AF Loharikar, A. Newton, A. E. Stroika, S. Freeman, M. Greene, K. D. Parsons, M. B. Bopp, C. Talkington, D. Mintz, E. D. Mahon, B. E. TI Cholera in the United States, 2001-2011: a reflection of patterns of global epidemiology and travel SO EPIDEMIOLOGY AND INFECTION LA English DT Article DE Cholera; diarrhoeal disease; Haiti; Hispaniola ID POLYMERASE-CHAIN-REACTION; VIBRIO-CHOLERAE; SURVEILLANCE NETWORK; HAITI; STRAINS AB US cholera surveillance offers insight into global and domestic trends. Between 2001 and 2011, 111 cases were reported to the Centers for Disease Control and Prevention. Cholera was associated with international travel in 90 (81%) patients and was domestically acquired in 20 (18%) patients; for one patient, information was not available. From January 2001 to October 2010, the 42 (47%) travel-associated cases were associated with travel to Asia. In October 2010, a cholera epidemic started in Haiti, soon spreading to the Dominican Republic (Hispaniola). From then to December 2011, 40 (83%) of the 48 travel-associated cases were associated with travel to Hispaniola. Of 20 patients who acquired cholera domestically, 17 (85%) reported seafood consumption; 10 (59%) ate seafood from the US Gulf Coast. In summary, an increase in travel-associated US cholera cases was associated with epidemic cholera in Hispaniola in 2010-2011. Travel to Asia and consumption of Gulf Coast seafood remained important sources of US cholera cases. C1 [Loharikar, A.] Ctr Dis Control & Prevent, Off Workforce & Career Dev, Atlanta, GA USA. [Newton, A. E.; Mahon, B. E.] Ctr Dis Control & Prevent, Enter Dis Epidemiol Branch, Div Foodborne Waterborne & Environm Dis, Atlanta, GA USA. [Stroika, S.; Freeman, M.; Greene, K. D.; Parsons, M. B.; Bopp, C.; Talkington, D.] Ctr Dis Control & Prevent, Enter Dis Lab Branch, Div Foodborne Waterborne & Environm Dis, Atlanta, GA USA. [Mintz, E. D.] Ctr Dis Control & Prevent, Waterborne Dis Prevent Branch, Div Foodborne Waterborne & Environm Dis, Atlanta, GA USA. RP Loharikar, A (reprint author), 1600 Clifton Rd, Atlanta, GA 30333 USA. EM anagha.loharikar@gmail.com FU Intramural CDC HHS [CC999999] NR 37 TC 5 Z9 5 U1 2 U2 6 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 EI 1469-4409 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD MAR PY 2015 VL 143 IS 4 BP 695 EP 703 DI 10.1017/S0950268814001186 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CD4NB UT WOS:000351058600004 PM 24865664 ER PT J AU Sreenivasan, N Gotestrand, SA Ombeki, S Oluoch, G Fischer, TK Quick, R AF Sreenivasan, N. Gotestrand, S. A. Ombeki, S. Oluoch, G. Fischer, T. K. Quick, R. TI Evaluation of the impact of a simple hand-washing and water-treatment intervention in rural health facilities on hygiene knowledge and reported behaviours of health workers and their clients, Nyanza Province, Kenya, 2008 SO EPIDEMIOLOGY AND INFECTION LA English DT Article DE Hand hygiene; hospital-acquired (nosocomial) infections; water (safe) ID CLUSTER RANDOMIZED-TRIAL; INFLUENZA TRANSMISSION; HOUSEHOLDS; FACEMASKS; DIARRHEA; HOME AB Many clinics in rural western Kenya lack access to safe water and hand-washing facilities. To address this problem, in 2005 a programme was initiated to install water stations for hand washing and drinking water in 109 health facilities, train health workers on water treatment and hygiene, and motivate clients to adopt these practices. In 2008, we evaluated this intervention's impact by conducting observations at facilities, and interviewing staff and clients about water treatment and hygiene. Of 30 randomly selected facilities, 97% had water stations in use. Chlorine residuals were detectable in at least one container at 59% of facilities. Of 164 interviewed staff, 79% knew the recommended water-treatment procedure. Of 298 clients, 45% had received training on water treatment at a facility; of these, 68% knew the recommended water-treatment procedure. Use of water stations, water treatment, and client training were sustained in some facilities for up to 3 years. C1 [Sreenivasan, N.; Gotestrand, S. A.] Univ Copenhagen, Fac Hlth Sci, DK-1168 Copenhagen, Denmark. [Sreenivasan, N.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Ombeki, S.; Oluoch, G.] CARE Kenya, Nairobi, Kenya. [Fischer, T. K.] Rigshosp, Dept Infect Dis, DK-2100 Copenhagen, Denmark. [Fischer, T. K.] Statens Serum Inst, Dept Virol, DK-2300 Copenhagen, Denmark. [Quick, R.] Ctr Dis Control & Prevent, Waterborne Dis Prevent Branch, Atlanta, GA 30333 USA. RP Sreenivasan, N (reprint author), Ctr Dis Control & Prevent, Waterborne Dis Prevent Branch, 1600 Clifton Rd MS A-38, Atlanta, GA 30333 USA. EM vii2@cdc.gov OI Fischer, Thea Kolsen/0000-0003-4812-980X FU CARE-CDC Health Initiative - Woodruff Foundation; Danida; Danish Council for Independent Research/Medical Sciences [271-07-0860, 271-07-0861] FX This evaluation could not have been performed without the help of the following staff: Beatrice Ohula, Raphael Ochieng, Dorkus Ngasi and David Omondi. We also thank the staff at the Nyando Integrated Child Health and Education Project for all their help and support. This paper is dedicated to the memory of Alfredo Obure (1976-2009). This evaluation was supported by the CARE-CDC Health Initiative (funded by the Woodruff Foundation), Danida and the Danish Council for Independent Research/Medical Sciences (reference numbers 271-07-0860 and 271-07-0861). The findings and conclusions in this report are those of the authors and do not necessarily represent those of the CDC. NR 15 TC 2 Z9 2 U1 1 U2 9 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 EI 1469-4409 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD MAR PY 2015 VL 143 IS 4 BP 873 EP 880 DI 10.1017/S095026881400082X PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CD4NB UT WOS:000351058600028 PM 24865584 ER PT J AU Ranjan, P Singh, N Kumar, A Neerincx, A Kremmer, E Cao, WP Davis, WG Katz, JM Gangappa, S Lin, RT Kufer, TA Sambhara, S AF Ranjan, Priya Singh, Neetu Kumar, Amrita Neerincx, Andreas Kremmer, Elisabeth Cao, Weiping Davis, William G. Katz, Jacqueline M. Gangappa, Shivaprakash Lin, Rongtuan Kufer, Thomas A. Sambhara, Suryaprakash TI NLRC5 interacts with RIG-I to induce a robust antiviral response against influenza virus infection SO EUROPEAN JOURNAL OF IMMUNOLOGY LA English DT Article DE Influenza; Interferon; NLRC5; NS1; RIG-I Antiviral ID NUCLEOTIDE-BINDING DOMAIN; NF-KAPPA-B; FAMILY-MEMBER NLRC5; NOD-LIKE RECEPTORS; NS1 PROTEIN; A-VIRUS; IMMUNE-RESPONSES; GENE-EXPRESSION; PATHOGEN RECOGNITION; SIGNALING PATHWAYS AB The NLR protein, NLRC5 is an important regulator of MHC class I gene expression, however, the role of NLRC5 in other innate immune responses is less well defined. In the present study, we report that NLRC5 binds RIG-I and that this interaction is critical for robust antiviral responses against influenza virus. Overexpression of NLRC5 in the human lung epithelial cell line, A549, and normal human bronchial epithelial cells resulted in impaired replication of influenza virus A/Puerto Rico/8/34 virus (PR8) and enhanced IFN- expression. Influenza virus leads to induction of IFN- that drives RIG-I and NLRC5 expression in host cells. Our results suggest that NLRC5 extends and stabilizes influenza virus induced RIG-I expression and delays expression of the viral inhibitor protein NS1. We show that NS1 binds to NLRC5 to suppress its function. Interaction domain mapping revealed that NLRC5 interacts with RIG-I via its N-terminal death domain and that NLRC5 enhanced antiviral activity in an leucine-rich repeat domain independent manner. Taken together, our findings identify a novel role for NLRC5 in RIG-I-mediated antiviral host responses against influenza virus infection, distinguished from the role of NLRC5 in MHC class I gene regulation. C1 [Ranjan, Priya; Singh, Neetu; Kumar, Amrita; Cao, Weiping; Davis, William G.; Katz, Jacqueline M.; Gangappa, Shivaprakash; Sambhara, Suryaprakash] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Neerincx, Andreas] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England. [Kremmer, Elisabeth] Helmholtz Zentrum Munchen, Inst Mol Immunol, Munich, Germany. [Lin, Rongtuan] McGill Univ, Dept Med, Montreal, PQ, Canada. [Kufer, Thomas A.] Univ Hohenheim, Inst Nutr Med, Dept Immunol, Stuttgart, Germany. RP Ranjan, P (reprint author), Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM pranjan@cdc.gov; thomas.kufer@uni-hohenheim.de RI Kufer, Thomas/I-5146-2015 OI Kufer, Thomas/0000-0003-4563-0412 FU German Research Foundation (DFG) [SFB670, KU1945/2-1]; Koeln Fortune Program/Faculty of Medicine, University of Cologne FX This work was supported by the German Research Foundation (DFG) grants SFB670 and KU1945/2-1 to T.A.K. A.N. acknowledges support by the Koeln Fortune Program/Faculty of Medicine, University of Cologne. NR 57 TC 11 Z9 12 U1 1 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0014-2980 EI 1521-4141 J9 EUR J IMMUNOL JI Eur. J. Immunol. PD MAR PY 2015 VL 45 IS 3 BP 758 EP 772 DI 10.1002/eji.201344412 PG 15 WC Immunology SC Immunology GA CD6TZ UT WOS:000351223700014 PM 25404059 ER PT J AU Jacob, V Qu, SL Chattopadhyay, S Sipe, TA Knopf, JA Goetzel, RZ Finnie, R Thota, AB AF Jacob, Verughese Qu, Shuli Chattopadhyay, Sajal Sipe, Theresa Ann Knopf, John A. Goetzel, Ron Z. Finnie, Ramona Thota, Anilkrishna B. CA Community Preventive Serv Task TI Legislations and Policies to Expand Mental Health and Substance Abuse Benefits in Health Insurance Plans: A Community Guide Systematic Economic Review SO JOURNAL OF MENTAL HEALTH POLICY AND ECONOMICS LA English DT Review ID LARGE EMPLOYER GROUP; FEDERAL-EMPLOYEES; MANAGED CARE; PARITY; SERVICES; IMPACTS; PROGRAM; COST; LAWS AB Background: Health insurance plans have historically limited the benefits for mental health and substance abuse (MH/SA) services compared to benefits for physical health services. In recent years, legislative and policy initiatives in the U.S. have been taken to expand MH/SA health insurance benefits and achieve parity with physical health benefits. The relevance of these legislations for international audiences is also explored, particularly for the European context. Aims of the Study: This paper reviews the evidence of costs and economic benefits of legislative or policy interventions to expand MH/SA health insurance benefits in the U.S. The objectives are to assess the economic value of the interventions by comparing societal cost to societal benefits, and to determine impact on costs to insurance plans resulting from expansion of these benefits. Methods: The search for economic evidence covered literature published from January 1950 to March 2011 and included evaluations of federal and state laws or rules that expanded MH/SA benefits as well as voluntary actions by large employers. Two economists screened and abstracted the economic evidence of MH/SA benefits legislation based on standard economic and actuarial concepts and methods. Results: The economic review included 12 studies: eleven provided evidence on cost impact to health plans, and one estimated the effect on suicides. There was insufficient evidence to determine if the intervention was cost-effective or cost-saving. However, the evidence indicates that MH/SA benefits expansion did not lead to any substantial increase in costs to insurance plans, measured as a percentage of insurance premiums. Discussion and Limitations: This review is unable to determine the overall economic value of policies that expanded MH/SA insurance benefits due to lack of cost-effectiveness and cost-benefit studies, predominantly due to the lack of evaluations of morbidity and mortality outcomes. This may be remedied in time when long-term MH/SA patient-level data becomes available to researchers. A limitation of this review is that legislations considered here have been superseded by recent legislations that have stronger and broader impacts on MH/SA benefits within private and public insurance: Mental Health Parity and Addiction Equity Act of 2008 (MHPAEA) and the Patient Protection and Affordable Care Act of 2010 (ACA). Implications for Future Research: Economic assessments over the long term such as cost per QALY saved and cost-benefit will be feasible as more data becomes available from plans that implemented recent expansions of MH/SA benefits. Results from these evaluations will allow a better estimate of the economic impact of the interventions from a societal perspective. Future research should also evaluate the more downstream effects on business decisions about labor, such as effects on hiring, retention, and the offer of health benefits as part of an employee compensation package. Finally, the economic effect of the far reaching ACA of 2010 on mental health and substance abuse prevalence and care is also a subject for future research. C1 [Jacob, Verughese; Qu, Shuli; Chattopadhyay, Sajal; Sipe, Theresa Ann; Knopf, John A.; Finnie, Ramona; Thota, Anilkrishna B.] Ctr Dis Control & Prevent CDC, Atlanta, GA USA. RP Jacob, V (reprint author), Ctr Dis Control & Prevent, Community Guide Branch, 1600 Clifton Rd,Mailstop E69, Atlanta, GA 30333 USA. EM hir0@cdc.gov FU Intramural CDC HHS [CC999999] NR 39 TC 1 Z9 1 U1 2 U2 7 PU INT CTR MENTAL HEALTH POLICY & ECONOMICS-ICMPE PI MILANO PA VIA DANIELE CRESPI 7, MILANO, 20123, ITALY SN 1091-4358 J9 J MENT HEALTH POLICY JI J. Ment. Health Policy Econ. PD MAR PY 2015 VL 18 IS 1 BP 39 EP 48 PG 10 WC Health Policy & Services; Psychiatry SC Health Care Sciences & Services; Psychiatry GA CE0IT UT WOS:000351488400005 PM 25862203 ER PT J AU Owusu-Edusei, K Flagg, EW Gift, TL AF Owusu-Edusei, Kwame Flagg, Elaine W. Gift, Thomas L. TI Hospitalization Cost per Case of Neonatal Herpes Simplex Virus Infection From Claims Data SO JOURNAL OF PEDIATRIC NURSING-NURSING CARE OF CHILDREN & FAMILIES LA English DT Article DE Herpes simplex virus; Neonates; Inpatient cost; Insured population ID UNITED-STATES; CONGENITAL-SYPHILIS; ADMINISTRATIVE DATA; NEWBORN; DIAGNOSIS AB The purpose of this study was to estimate the average excess inpatient cost of neonatal herpes simplex virus (NHSV) infection from 2005 to 2009 insurance claims data. The estimated adjusted average excess inpatient cost for neonate admissions with HSV diagnosis and >7 days of hospitalization was $40,044 [95% confidence interval (CI), $33,52-$47,775]. When disaggregated by the days of admission, cost estimates were: 8-13 days, $23,918 [CI, $19,490-$29,282]; 14-21 days, $44,358 [CI, $34,654-$56,673]; >21 days, $68,916 [CI, $49,905-$94,967]). Although these estimates are not representative of the entire US, they can inform future economic evaluation studies on NHSV interventions. Published by Elsevier Inc. C1 [Owusu-Edusei, Kwame; Flagg, Elaine W.; Gift, Thomas L.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30333 USA. RP Owusu-Edusei, K (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30333 USA. EM Kowusuedusei@cdc.gov NR 27 TC 2 Z9 2 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0882-5963 J9 J PEDIATR NURS JI J. Pediatr. Nurs. PD MAR-APR PY 2015 VL 30 IS 2 BP 346 EP 352 DI 10.1016/j.pedn.2014.08.004 PG 7 WC Nursing; Pediatrics SC Nursing; Pediatrics GA CE0GE UT WOS:000351481700011 PM 25193688 ER PT J AU Chatterji, P Decker, SL Markowitz, S AF Chatterji, Pinka Decker, Sandra L. Markowitz, Sara TI The Effects of Mandated Health Insurance Benefits for Autism on Out-of-Pocket Costs and Access to Treatment SO JOURNAL OF POLICY ANALYSIS AND MANAGEMENT LA English DT Article ID MENTAL-HEALTH; SPECTRUM DISORDERS; PARITY LEGISLATION; FINANCIAL BURDEN; CARE UTILIZATION; IN-DIFFERENCES; CHILDREN; LAWS; EXPENDITURES; SERVICES AB As of 2014, 37 states have passed mandates requiring many private health insurance policies to cover diagnostic and treatment services for autism spectrum disorders (ASDs). We explore whether ASD mandates are associated with out-of-pocket costs, financial burden, and cost or insurance-related problems with access to treatment among privately insured children with special health care needs (CSHCNs). We use difference-in-difference and difference-in-difference-in-difference approaches, comparing pre-post mandate changes in outcomes among CSHCN who have ASD versus CSHCN other than ASD. Data come from the 2005 to 2006 and the 2009 to 2010 waves of the National Survey of CSHCN. Based on the model used, our findings show no statistically significant association between state ASD mandates and caregivers' reports about financial burden, access to care, and unmet need for services. However, we do find some evidence that ASD mandates may have beneficial effects in states in which greater percentages of privately insured individuals are subject to the mandates. We caution that we do not study the characteristics of ASD mandates in detail, and most ASD mandates have gone into effect very recently during our study period. C1 [Chatterji, Pinka; Markowitz, Sara] Natl Bur Econ Res, Cambridge, MA 02138 USA. [Chatterji, Pinka] SUNY Albany, Dept Econ, Albany, NY 12222 USA. [Decker, Sandra L.] Natl Ctr Hlth Stat, New York, NY USA. [Decker, Sandra L.] Ctr Dis Control & Prevent, Hyattsville, MD 20782 USA. [Markowitz, Sara] Emory Univ, Dept Econ, Atlanta, GA 30322 USA. RP Chatterji, P (reprint author), Natl Bur Econ Res, Cambridge, MA 02138 USA. EM pchatterji@albany.edu; sdecker@cdc.gov; smarko2@emory.edu FU University at Albany Center for Social and Demographic Analysis (CSDA) Junior Researcher Program; University at Albany College of Arts Sciences FRAP FX We would like to thank Jennifer Madans, Matthew Bramlett, Scott Grosse, and Jennifer Parker of the Centers for Disease Control and Prevention for helpful comments on a previous draft. We thank participants and our discussant at the 2012 American Society of Health Economists Annual Conference for useful feedback. P.C. acknowledges funding from the University at Albany Center for Social and Demographic Analysis (CSDA) Junior Researcher Program and from the University at Albany College of Arts & Sciences FRAP small grants program. The findings and conclusions in this article are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 52 TC 7 Z9 7 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0276-8739 EI 1520-6688 J9 J POLICY ANAL MANAG JI J. Policy Anal. Manage. PD SPR PY 2015 VL 34 IS 2 BP 328 EP + DI 10.1002/pam.21814 PG 33 WC Economics; Public Administration SC Business & Economics; Public Administration GA CD6TJ UT WOS:000351222000005 PM 25893237 ER PT J AU Komar, N Panella, NA Young, GR Basile, AJ AF Komar, Nicholas Panella, Nicholas A. Young, Ginger R. Basile, Alison J. TI METHODS FOR DETECTION OF WEST NILE VIRUS ANTIBODIES IN MOSQUITO BLOOD MEALS SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Mosquito; blood meal; antibody; West Nile virus; surveillance ID AVIAN HOSTS AB We describe and compare 2 qualitative serologic techniques for detecting West Nile virus (WNV)-specific antibodies in mosquito blood meals. The techniques are the biotin microsphere immunoassay (b-MIA) and the inhibition platform of the VectorTest (TM) WNV antigen assay (VecTest-inhibition). To demonstrate the ability of these tests to detect WNV-neutralizing antibodies, we experimentally exposed feeding mosquitoes to blood containing 5 concentrations of 6B6C-1, a flavivirus-neutralizing monoclonal antibody. Antibody concentrations were quantified using the 90% plaque-reduction neutralization test (PRNT90). After 24 h of blood-meal digestion at 22.5 degrees C, the threshold PRNT90 titer of detection was <= 18 for b-MIA and <= 50 for VecTest-inhibition. Both tests reliably detected antibodies in 3 of 3 blood meals that had been digested for up to 30 h, or were about 25% digested. The b-MIA was also applied to mosquitoes that had engorged on avian blood in Arizona following a WNV epidemic in 2010. There was no significant difference in the WNV antibody prevalence determined by b-MIA (52% of 71 avian blood meals) compared to the WNV-neutralizing antibody prevalence in birds determined by direct sampling (49% of 234 birds). VecTest-inhibition requires fewer resources and may be used in the field without a laboratory, but consumes the entire blood meal and relies on subjective interpretation of results. The b-MIA requires a laboratory and sophisticated equipment and reagents. Results for b-MIA are analyzed objectively and can be applied to mosquito blood meals with greater confidence than the VecTest-inhibition method and thus can contribute substantially to research and surveillance programs that would benefit from the detection of specific WNV antibodies in mosquito blood meals. C1 [Komar, Nicholas; Panella, Nicholas A.; Young, Ginger R.; Basile, Alison J.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. RP Komar, N (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, 3156 Rampart Rd, Ft Collins, CO 80521 USA. FU CDC FX We thank Janeen Laven for advice and technical assistance for using the b-MIA assay. Alex Pauvolid-Correa provided the WNV cell-lysate antigen used in the VecTest-inhibition assay. The Vector Test assay kits used in this evaluation were provided by Kirti Dave of Vector Test Systems, Inc. The authors declare no financial interest in Vector Test Systems, Inc. The CDC mosquito resting traps are now commercially available from Bioquip Inc. The Bioquip (R) mosquito resting trap is sold under license from the CDC for US Patent no. 2010/0319240 Al; CDC may benefit financially from the sales of this product. NR 15 TC 0 Z9 0 U1 0 U2 4 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X EI 1943-6270 J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD MAR PY 2015 VL 31 IS 1 BP 1 EP 6 PG 6 WC Entomology SC Entomology GA CD8DZ UT WOS:000351326700001 PM 25843170 ER PT J AU Mackay, AJ Amador, M Felix, G Acevedo, V Barrera, R AF Mackay, Andrew J. Amador, Manuel Felix, Gilberto Acevedo, Veronica Barrera, Roberto TI EVALUATION OF HOUSEHOLD BLEACH AS AN OVICIDE FOR THE CONTROL OF AEDES AEGYPTI SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Aedes aegypti; control; ovicide; vector; dengue; sodium hypochlorite ID BREEDING SITES; PUERTO-RICO; DRY SEASON; MOSQUITO; EGGS; CULICIDAE; SURVIVAL; DIPTERA; WASHBASINS; DENSITIES AB Accumulations of dormant eggs in container habitats allow Aedes aegypti populations to survive harsh environmental conditions and may frustrate control interventions directed at larval and adult life stages. While sodium hypochlorite solutions (NaOCl) have long been recognized as ovicides for use against dengue vectors, the susceptibility of eggs to spray applications has not been robustly evaluated on substrate materials representative of the most frequently utilized artificial container habitats. Experiments were performed under controlled and natural conditions by applying dilutions of household bleach (52.5 ppt NaOCl) as a spray to eggs on plastic, rubber, and concrete surfaces, with and without a smectite clay thickener. Laboratory assays identified the minimum NaOCl concentrations required to eliminate eggs on plastic (10 ppt), rubber (20 ppt) and concrete (20 ppt) surfaces. Addition of smectite clay reduced the minimum effective concentration to 10 ppt NaOCl for all 3 substrates. A minimum exposure period of 24 h was required to completely eliminate egg viability on concrete surfaces, even at the highest NaOCl concentration (52.5 ppt). Field experiments verified that spray application of a 1:3 dilution of household bleach mixed with smectite clay can reduce egg hatching by >= 99% in shaded and sun-exposed plastic containers. Similarly, 4:1 dilution of household bleach (with or without smectite clay) eliminated a >= 98% of eggs from concrete surfaces in outdoor, water-filled drums. In this study, we propose a practical, effective and safe strategy for using household bleach to eliminate Ae. aegypti eggs in a range of artificial container habitats. C1 [Mackay, Andrew J.; Amador, Manuel; Felix, Gilberto; Acevedo, Veronica; Barrera, Roberto] Ctr Dis Control & Prevent, Dengue Branch, Entomol & Ecol Act, San Juan, PR 00920 USA. RP Mackay, AJ (reprint author), Univ Illinois, Dept Entomol, 320 Morrill Hall, Urbana, IL 61801 USA. FU Intramural CDC HHS [CC999999] NR 36 TC 1 Z9 1 U1 2 U2 5 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X EI 1943-6270 J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD MAR PY 2015 VL 31 IS 1 BP 77 EP 84 PG 8 WC Entomology SC Entomology GA CD8DZ UT WOS:000351326700010 PM 25843179 ER PT J AU Irish, SR Batengana, BM Eiras, AE Cameron, MM AF Irish, S. R. Batengana, B. M. Eiras, A. E. Cameron, M. M. TI EVALUATION OF THE ATRAEDES (TM) LURE FOR COLLECTION OF CULEX QUINQUEFASCIATUS IN GRAVID TRAPS SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE AtrAedes; gravid trap; Culex quinquefasciatus; Tanzania ID BERMUDA GRASS INFUSIONS; AEDES-AEGYPTI AB The typical attractant used in gravid trapping of Culex quinquefasciatus is an aged infusion of organic materials, which can change in attractiveness over time. A standardized chemical attractant dispenser derived from grass infusion, the AtrAedesr (TM) lure, has been produced for the surveillance of the dengue vector Aedes aegypti. A study using this lure in combination with the Centers for Disease Control and Prevention gravid traps was conducted in Tanga, Tanzania. The addition of the lure to traps baited with either grass infusion or tap water did not result in significant increases in trap catch. Grass infusion baited traps (with and without the AtrAedes lure) collected significantly more Cx. quinquefasciatus than traps baited with AtrAedes + tap water, tap water alone, or AtrAedes alone. The catches of the traps baited with AtrAedes + tap water, tap water alone, and AtrAedes alone were not significantly different from each other. Although the placement of the lure in the base of the trap may have decreased trap catches, it seems that the AtrAedes is not as effective as grass infusion for collecting Cx. quinquefasciatus in Tanzania. C1 [Irish, S. R.; Cameron, M. M.] London Sch Hyg & Trop Med, London WC1, England. [Batengana, B. M.] Natl Inst Med Res, Amani Med Res Ctr, Muheza, Tanzania. [Eiras, A. E.] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Parasitol, Belo Horizonte, MG, Brazil. RP Irish, SR (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop G49, Atlanta, GA 30329 USA. FU AgriSense BCS Ltd. (Pontypridd, Wales, UK); Gordon Smith Travelling Fellowship; London School of Hygiene and Tropical Medicine FX Matt Kirby of the PRISM project, Bombo Regional Hospital, the Assistant Medical Officers Training Centre, and the office of the National Program for the Elimination of Lymphatic Filariasis are warmly thanked. Alvaro E. Eiras thanks CNPq (PRONEX-Dengue). The funding for this study was provided by AgriSense BCS Ltd. (Pontypridd, Wales, UK), the Gordon Smith Travelling Fellowship, and the London School of Hygiene and Tropical Medicine. The anonymous reviewers are acknowledged for their help in improving the manuscript. NR 10 TC 0 Z9 0 U1 1 U2 3 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X EI 1943-6270 J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD MAR PY 2015 VL 31 IS 1 BP 107 EP 109 PG 3 WC Entomology SC Entomology GA CD8DZ UT WOS:000351326700016 PM 25843185 ER PT J AU Kurbatova, EV Cegielski, JP Lienhardt, C Akksilp, R Bayona, J Becerra, MC Caoili, J Contreras, C Dalton, T Danilovits, M Demikhova, OV Ershova, J Gammino, VM Gelmanova, I Heilig, CM Jou, R Kazennyy, B Keshavjee, S Kim, HJ Kliiman, K Kvasnovsky, C Leimane, V Mitnick, CD Quelapio, I Riekstina, V Smith, SE Tupasi, T van der Walt, M Vasilyeva, IA Via, LE Viiklepp, P Volchenkov, G Walker, AT Wolfgang, M Yagui, M Zignol, M AF Kurbatova, Ekaterina V. Cegielski, J. Peter Lienhardt, Christian Akksilp, Rattanawadee Bayona, Jaime Becerra, Mercedes C. Caoili, Janice Contreras, Carmen Dalton, Tracy Danilovits, Manfred Demikhova, Olga V. Ershova, Julia Gammino, Victoria M. Gelmanova, Irina Heilig, Charles M. Jou, Ruwen Kazennyy, Boris Keshavjee, Salmaan Kim, Hee Jin Kliiman, Kai Kvasnovsky, Charlotte Leimane, Vaira Mitnick, Carole D. Quelapio, Imelda Riekstina, Vija Smith, Sarah E. Tupasi, Thelma van der Walt, Martie Vasilyeva, Irina A. Via, Laura E. Viiklepp, Piret Volchenkov, Grigory Walker, Allison Taylor Wolfgang, Melanie Yagui, Martin Zignol, Matteo TI Sputum culture conversion as a prognostic marker for end-of-treatment outcome in patients with multidrug-resistant tuberculosis: a secondary analysis of data from two observational cohort studies SO LANCET RESPIRATORY MEDICINE LA English DT Article ID PULMONARY TUBERCULOSIS; CLINICAL-TRIALS; METAANALYSIS; MOXIFLOXACIN; PREDICTORS; DRUGS AB Background Sputum culture conversion is often used as an early microbiological endpoint in phase 2 dinical trials of tuberculosis treatment on the basis of its assumed predictive value for end-of-treatment outcome, particularly in patients with drug-susceptible tuberculosis. We aimed to assess the validity of sputum culture conversion on solid media at varying timepoints, and the time to conversion, as prognostic markers for end-of-treatment outcome in patients with multidrug-resistant (MDR) tuberculosis. Methods We analysed data from two large cohort studies of patients with MDR tuberculosis. We defined sputum culture conversion as two or more consecutive negative cultures from sputum samples obtained at least 30 days apart. To estimate the association of 2 month and 6 month conversion with successful treatment outcome, we calculated odds ratios (ORs) and 95% CIs with random-effects multivariable logistic regression. We calculated predictive values with bivariate random-effects generalised linear mixed modelling. Findings We assessed data for 1712 patients who had treatment success, treatment failure, or who died. Among patients with treatment success, median time to sputum culture conversion was significantly shorter than in those who had poor outcomes (2 months [IQR 1-3] vs 7 months [3 to >= 24]; log-rank p<0.0001). Furthermore, conversion status at 6 months (adjusted OR 14.07 [95% CI 10.05-19.71]) was significantly associated with treatment success compared with failure or death. Sputum culture conversion status at 2 months was significantly associated with treatment success only in patients who were HIV negative (adjusted OR 4.12 [95% CI 2.25-7.54]) or who had unknown HIV infection (3.59 [1.96-6.58]), but not in those who were HIV positive (0.38 [0.12-1.18]). Thus, the overall association of sputum culture conversion with a successful outcome was substantially greater at 6 months than at 2 months. 2 month conversion had low sensitivity (27.3% [95% confidence limit 16.6-41.4]) and high specificity (89.8% [82.3-94.4]) for prediction of treatment success. Conversely, 6 month sputum culture conversion status had high sensitivity (91.8% [85.9-95.4]), but moderate specificity (57.8% [42.5-71.6]). The maximum combined sensitivity and specificity for sputum culture conversion was reached between month 6 and month 10 of treatment. Interpretation Time to sputum culture conversion, conversion status at 6 months, and conversion status at 2 months in patients without known HIV infection can be considered as proxy markers of end-of-treatment outcome in patients with MDR tuberculosis, although the overall association with treatment success is substantially stronger for 6 month than for 2 month conversion status. Investigators should consider these results regarding the validity of sputum culture conversion at various timepoints as an early predictor of treatment efficacy when designing phase 2 studies before investing substantial resources in large, long-term, phase 3 trials of new treatments for MDR tuberculosis. Copyright (C) 2015. World Health Organization. Published by Elsevier Ltd/Inc/BV. All rights reserved. C1 [Kurbatova, Ekaterina V.; Cegielski, J. Peter; Dalton, Tracy; Ershova, Julia; Gammino, Victoria M.; Heilig, Charles M.; Kvasnovsky, Charlotte; Smith, Sarah E.; Walker, Allison Taylor; Wolfgang, Melanie] US Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30329 USA. [Lienhardt, Christian; Zignol, Matteo] WHO, CH-1211 Geneva, Switzerland. [Akksilp, Rattanawadee] Off Dis Prevent & Control, Ubon Ratchathani, Thailand. [Bayona, Jaime; Becerra, Mercedes C.; Gelmanova, Irina; Keshavjee, Salmaan; Mitnick, Carole D.] Harvard Univ, Sch Med, Boston, MA USA. [Bayona, Jaime; Becerra, Mercedes C.; Gelmanova, Irina; Keshavjee, Salmaan; Mitnick, Carole D.] Partners In Hlth, Boston, MA USA. [Caoili, Janice; Quelapio, Imelda; Tupasi, Thelma] Trop Dis Fdn, Manila, Philippines. [Contreras, Carmen] Socios Salud Sucursal, Lima, Peru. [Danilovits, Manfred; Kliiman, Kai] Tartu Univ Hosp, Tartu, Estonia. [Demikhova, Olga V.; Vasilyeva, Irina A.] Russian Acad Med Sci, Cent TB Res Inst, Moscow, Russia. [Jou, Ruwen] Taiwan Ctr Dis Control, Reference Lab Mycobacteriol, Taipei, Taiwan. [Kazennyy, Boris] Orel Oblast TB Dispensary, Oryol, Russia. [Kim, Hee Jin] Korean Inst TB, Seoul, South Korea. [Leimane, Vaira; Riekstina, Vija] Riga East Univ Hosp, TB & Lung Dis Ctr, Riga, Latvia. [van der Walt, Martie] MRC, Pretoria, South Africa. [Via, Laura E.] NIAID, NIH, Bethesda, MD 20892 USA. [Viiklepp, Piret] Natl Inst Hlth Dev, Natl TB Registry, Tallinn, Estonia. [Volchenkov, Grigory] Vladimir Oblast TB Dispensary, Vladimir, Russia. [Yagui, Martin] Natl Inst Hlth, Lima, Peru. RP Kurbatova, EV (reprint author), US Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30329 USA. EM ekurbatova@cdc.gov OI Heilig, Charles/0000-0003-1075-1310 FU United States Agency for International Development (USAID); US Centers for Disease Control and Prevention (CDC); Division of Intramural Research of the US National Institute of Allergy and Infectious Diseases; Korea Centers for Disease Control and Prevention FX The United States Agency for International Development (USAID) and US Centers for Disease Control and Prevention (CDC) provided funding for both the Preserving Effective TB Treatment Study (PETTS) study and the DOTS-Plus Pilot Projects Case-Based Study. The Division of Intramural Research of the US National Institute of Allergy and Infectious Diseases and the Korea Centers for Disease Control and Prevention partly supported the Korean sites. CL and MZ are WHO staff members. The authors alone are responsible for the views expressed in this publication and they do not necessarily represent the decisions or policies of WHO. The conclusions and interpretations of data presented in this report are solely those of the authors and do not necessarily represent an official position of the CDC, the US Government, WHO, or the governments of the nine participating countries. NR 26 TC 20 Z9 20 U1 1 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 2213-2600 J9 LANCET RESP MED JI Lancet Resp. Med. PD MAR PY 2015 VL 3 IS 3 BP 201 EP 209 DI 10.1016/S2213-2600(15)00036-3 PG 9 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA CE0FN UT WOS:000351480000016 PM 25726085 ER PT J AU Phelan, EA Mahoney, JE Voit, JC Stevens, JA AF Phelan, Elizabeth A. Mahoney, Jane E. Voit, Jan C. Stevens, Judy A. TI Assessment and Management of Fall Risk in Primary Care Settings SO MEDICAL CLINICS OF NORTH AMERICA LA English DT Article DE Accidental falls; Aged; Wounds and injuries; Primary prevention; Secondary prevention; Risk assessment and management; Preventive health services/organization and administration; Community health services ID RANDOMIZED CONTROLLED-TRIAL; OLDER-ADULTS; ELDERLY PERSONS; PREVENTION INTERVENTIONS; COMMUNITY; PREVALENCE; EXERCISE; BALANCE; PARTICIPATION; METAANALYSIS AB Falls among older adults are neither purely accidental nor inevitable; research has shown that many falls are preventable. Primary care providers play a key role in preventing falls. However, fall risk assessment and management is performed infrequently in primary care settings. This article provides an overview of a clinically relevant, evidence-based approach to fall risk screening and management. It describes resources, including the STEAD! (Stopping Elderly Accidents, Deaths, and Injuries) tool kit that can help providers integrate fall prevention into their practice. C1 [Phelan, Elizabeth A.] Univ Washington, Harborview Med Ctr, Div Gerontol & Geriatr Med, Seattle, WA 98104 USA. [Mahoney, Jane E.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Div Geriatr & Gerontol, Madison, WI 53705 USA. [Voit, Jan C.] Univ Washington, Harborview Med Ctr, Outpatient Phys & Hand Therapy Clin, Seattle, WA 98104 USA. [Stevens, Judy A.] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA. RP Phelan, EA (reprint author), Univ Washington, Harborview Med Ctr, Div Gerontol & Geriatr Med, 325 9th Ave,Box 359755, Seattle, WA 98104 USA. EM phelane@uw.edu FU Intramural CDC HHS [CC999999] NR 46 TC 7 Z9 7 U1 5 U2 16 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0025-7125 EI 1557-9859 J9 MED CLIN N AM JI Med. Clin. N. Am. PD MAR PY 2015 VL 99 IS 2 BP 281 EP + DI 10.1016/j.mcna.2014.11.004 PG 14 WC Medicine, General & Internal SC General & Internal Medicine GA CD8CH UT WOS:000351322300006 PM 25700584 ER PT J AU Chen, B Redmond, N AF Chen, Bin Redmond, Nakeva TI Evaluation of a continuing education activity for quality practices in biochemical genetic testing and newborn screening SO MOLECULAR GENETICS AND METABOLISM LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-for-Inherited-Metabolic-Disorders (SIMD) CY MAR 28-31, 2015 CL Salt Lake City, UT SP Soc Inherited Metab Disorders C1 Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1096-7192 EI 1096-7206 J9 MOL GENET METAB JI Mol. Genet. Metab. PD MAR PY 2015 VL 114 IS 3 MA 20 BP 334 EP 335 PG 2 WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research & Experimental SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental Medicine GA CD6IC UT WOS:000351191800050 ER PT J AU Mei, J Zhou, H Lee, F Williams, I Zobel, S De Jesus, V Vogt, R AF Mei, Joanne Zhou, Hui Lee, Francis Williams, Irene Zobel, Sherri De Jesus, Victor Vogt, Robert TI Proficiency testing for lysosomal storage disorders in dried blood spots to detect Krabbe and Pompe diseases SO MOLECULAR GENETICS AND METABOLISM LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-for-Inherited-Metabolic-Disorders (SIMD) CY MAR 28-31, 2015 CL Salt Lake City, UT SP Soc Inherited Metab Disorders C1 [Mei, Joanne; Zhou, Hui; Lee, Francis; Williams, Irene; Zobel, Sherri; De Jesus, Victor; Vogt, Robert] Ctr Dis Control & Prevent, Newborn Screening Qual Assurance Program, Atlanta, GA 30341 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1096-7192 EI 1096-7206 J9 MOL GENET METAB JI Mol. Genet. Metab. PD MAR PY 2015 VL 114 IS 3 MA 21 BP 335 EP 335 PG 1 WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research & Experimental SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental Medicine GA CD6IC UT WOS:000351191800051 ER PT J AU Maalouf, J Barron, J Gunn, JP Yuan, KM Perrine, CG Cogswell, ME AF Maalouf, Joyce Barron, Jessica Gunn, Janelle P. Yuan, Keming Perrine, Cria G. Cogswell, Mary E. TI Iodized Salt Sales in the United States SO NUTRIENTS LA English DT Article ID IODINE STATUS; NATIONAL-HEALTH; NUTRITION; DEFICIENCY; OUTCOMES; CHILDREN; FOODS AB Iodized salt has been an important source of dietary iodine, a trace element important for regulating human growth, development, and metabolic functions. This analysis identified iodized table salt sales as a percentage of retail salt sales using Nielsen ScanTrack. We identified 1117 salt products, including 701 salt blends and 416 other salt products, 57 of which were iodized. When weighted by sales volume in ounces or per item, 53% contained iodized salt. These findings may provide a baseline for future monitoring of sales of iodized salt. C1 [Maalouf, Joyce; Gunn, Janelle P.; Yuan, Keming; Cogswell, Mary E.] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Maalouf, Joyce] IHRC Inc, Atlanta, GA 30346 USA. [Barron, Jessica] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37831 USA. [Perrine, Cria G.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Maalouf, J (reprint author), Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. EM JMaalouf@cdc.gov; jessylbarron@gmail.com; JPeralezGunn@cdc.gov; KYuan@cdc.gov; CPerrine@cdc.gov; MCogswell@cdc.gov FU CDC FX This project was funded by the CDC. There were no external funding sources for this article. NR 19 TC 4 Z9 4 U1 0 U2 8 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2072-6643 J9 NUTRIENTS JI Nutrients PD MAR PY 2015 VL 7 IS 3 BP 1691 EP 1695 DI 10.3390/nu7031691 PG 5 WC Nutrition & Dietetics SC Nutrition & Dietetics GA CE6EU UT WOS:000351930200016 PM 25763528 ER PT J AU Jemmott, JB Stephens-Shields, A O'Leary, A Jemmott, LS Teitelman, A Ngwane, Z Mtose, X AF Jemmott, John B., III Stephens-Shields, Alisa O'Leary, Ann Jemmott, Loretta Sweet Teitelman, Anne Ngwane, Zolani Mtose, Xoliswa TI Mediation of effects of a theory-based behavioral intervention on self-reported physical activity in South African men SO PREVENTIVE MEDICINE LA English DT Article DE Mediation; Physical activity; Theory of planned behavior; South Africa; Men; Cluster-randomized controlled trial; Intervention study ID RANDOMIZED-CONTROLLED-TRIAL; RISK-REDUCTION INTERVENTION; PLANNED BEHAVIOR; CHRONIC DISEASES; SEXUAL-BEHAVIOR; REASONED ACTION; METAANALYSIS; ADOLESCENTS; HEALTH; POPULATION AB Objective. Increasing physical activity is an important public-health goal worldwide, but there are few published mediation analyses of physical-activity interventions in low-to-middle-income countries like South Africa undergoing a health transition involving markedly increased mortality from non-communicable diseases. This article reports secondary analyses on the mediation of a theory-of-planned-behavior-based behavioral intervention that increased self-reported physical activity in a trial with 1181 men in Eastern Cape Province, South Africa. Method. Twenty-two matched-pairs of neighborhoods were randomly selected. Within pairs, neighborhoods were randomized to a health-promotion intervention or an attention-matched control intervention with baseline, immediate-post, and 6- and 12-month post-intervention assessments. Theory-of-planned-behavior constructs measured immediately post-intervention were tested as potential mediators of the primary outcome, self-reported physical activity averaged over the 6- and 12-month post-intervention assessments, using a product-of-coefficients approach in a generalized-estimating-equations framework. Data were collected in 2007-2010. Results. Attitude, subjective norm, self-efficacy, and intention were significant mediators of intervention-induced increases in self-reported physical activity. The descriptive norm, not affected by the intervention, was not a mediator, but predicted increased self-reported physical activity. Conclusion. The results suggest that interventions targeting theory-of-planned-behavior constructs may contribute to efforts to increase physical activity to reduce the burden of non-communicable diseases among South African men. (C) 2015 Elsevier Inc. All rights reserved. C1 [Jemmott, John B., III] Univ PA, Dept Psychiat, Perelman Sch Med, Philadelphia, PA USA. [Jemmott, John B., III] Univ PA, Annenberg Sch Commun, Philadelphia, PA USA. [Stephens-Shields, Alisa] Univ PA, Ctr Clin Epidemiol & Biostat, Perelman Sch Med, Philadelphia, PA USA. [O'Leary, Ann] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. [Jemmott, Loretta Sweet; Teitelman, Anne] Univ PA, Sch Nursing, Philadelphia, PA USA. [Ngwane, Zolani] Haverford Coll, Dept Anthropol, Haverford, PA 19041 USA. [Mtose, Xoliswa] Univ Ft Hare, Fac Educ, Alice, South Africa. RP Jemmott, JB (reprint author), Univ Penn, Perelman Sch Med, Dept Psychiat, 3535 Market St,Suite 520, Philadelphia, PA 19104 USA. EM jjemmott@asc.upenn.edu FU National Institutes of Health [1 R01 HD053270] FX The authors appreciate the contributions of Craig Carty, MS, Deepti Chittamura, MIMS, Sonya Coombs, MS, Costa Gazi, MBBch, Lynette Gueits, MS, Janet Hsu, BA, G. Anita Heeren, PhD, Larry D. Icard, PhD, Shasta Jones, PhD, Monde Makiwane, PhD, Pretty Ndyebi, BA, Lulama Sidloyi, BA, and Robin Stevens, PhD, MPH. The contributions of the late Thomas Ten Have, PhD, to the conception and design of the trial are gratefully acknowledged. This study was funded by research grant 1 R01 HD053270 from the National Institutes of Health. The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and the decision to submit the manuscript for publication. The findings and conclusions in this report are those of the authors and do not necessarily represent the official views of the National Institutes of Health or the Centers for Disease Control and Prevention. NR 67 TC 2 Z9 2 U1 5 U2 9 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0091-7435 EI 1096-0260 J9 PREV MED JI Prev. Med. PD MAR PY 2015 VL 72 BP 1 EP 7 DI 10.1016/j.ypmed.2014.12.022 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA CD3ZJ UT WOS:000351022100001 PM 25565482 ER PT J AU Kawwass, JF Crawford, S Session, DR Kissin, DM Jamieson, DJ AF Kawwass, Jennifer F. Crawford, Sara Session, Donna R. Kissin, Dmitry M. Jamieson, Denise J. TI Endometriosis: National ART Trends and Outcomes, 2000-2011 SO REPRODUCTIVE SCIENCES LA English DT Meeting Abstract C1 [Kawwass, Jennifer F.; Session, Donna R.; Kissin, Dmitry M.; Jamieson, Denise J.] Emory Univ, Gynecol & Obstet, Atlanta, GA 30322 USA. [Kawwass, Jennifer F.; Crawford, Sara; Kissin, Dmitry M.; Jamieson, Denise J.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1933-7191 EI 1933-7205 J9 REPROD SCI JI Reprod. Sci. PD MAR PY 2015 VL 22 SU 1 MA F-045 BP 218A EP 219A PG 2 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA CD9GW UT WOS:000351407202111 ER PT J AU Judge, D Krause, V AF Judge, D. Krause, V TI MULTI-DRUG RESISTANT TUBERCULOSIS IN THE NORTHERN TERRITORY: A 10-YEAR RETROSPECTIVE CASE SERIES SO RESPIROLOGY LA English DT Meeting Abstract CT Thoracic Society Australia New Zealand Australian New Zealand Society Respiratory Science Annual Scientific Meeting 2015 CY MAR 27-APR 01, 2015 CL Queensland, AUSTRALIA C1 [Judge, D.] Royal Darwin Hosp, Tiwi, NT, Australia. [Krause, V] Ctr Dis Control, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1323-7799 EI 1440-1843 J9 RESPIROLOGY JI Respirology PD MAR PY 2015 VL 20 SU 2 SI SI MA TP 259 BP 156 EP 156 PG 1 WC Respiratory System SC Respiratory System GA CE0AQ UT WOS:000351464400407 ER PT J AU Jin, L Orvell, C Myers, R Rota, PA Nakayama, T Forcic, D Hiebert, J Brown, KE AF Jin, Li Orvell, Claes Myers, Richard Rota, Paul A. Nakayama, Tetsuo Forcic, Dubravko Hiebert, Joanne Brown, Kevin E. TI Genomic diversity of mumps virus and global distribution of the 12 genotypes SO REVIEWS IN MEDICAL VIROLOGY LA English DT Review ID GENETIC-CHARACTERIZATION; ASEPTIC-MENINGITIS; SEQUENCE-ANALYSIS; SH GENE; MOLECULAR CHARACTERIZATION; VACCINE STRAIN; YOUNG-ADULTS; F-PROTEIN; OUTBREAK; IDENTIFICATION AB The WHO recently proposed an updated nomenclature for mumps virus (MuV). WHO currently recognizes 12 genotypes of MuV, assigned letters from A to N (excluding E and M), which are based on the nucleotide sequences of small hydrophobic (SH) and haemagglutinin-neuraminidase (HN) genes. A total of 66 MuV genomes are available in GenBank, representing eight of the 12 genotypes. To complete this dataset, whole genomes of seven isolates representing six genotypes (D, H, I, J, K and L) and one unclassified strain were sequenced. SH and HN genes of other representative strains were also sequenced. The degree of genetic divergence, predicted amino acid substitutions in the HN and fusion (F) proteins and geographic distributions of MuV strains were analysed based on the updated dataset. Nucleotide heterogeneity between genotypes reached 20% within the SH gene, with a maximum of 9% within the HN gene. The geographic and chronologic distributions of the 12 genotypes were summarised. This review contributes to our understanding of strain diversity for wild type MuV, and the results support the current WHO nomenclature. (c) 2014 Crown copyright. Reviews in Medical Virology (c) 2014 John Wiley & Sons, Ltd. C1 [Jin, Li; Myers, Richard; Brown, Kevin E.] Publ Hlth England, Virus Reference Dept, Reference Microbiol Serv, London NW9 5EQ, England. [Orvell, Claes] Huddinge Univ Hosp, Div Clin Virol, Stockholm, Sweden. [Rota, Paul A.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Nakayama, Tetsuo] Kitasato Inst Life Sci, Tokyo, Japan. [Forcic, Dubravko] Univ Zagreb, Ctr Res & Knowledge Transfer Biotechnol, Zagreb 41000, Croatia. [Hiebert, Joanne] Publ Hlth Agcy Canada, Natl Microbiol Lab, Winnipeg, MB, Canada. RP Jin, L (reprint author), Publ Hlth England, Virus Reference Dept, Reference Microbiol Serv, 61 Colindale Ave, London NW9 5EQ, England. EM li.jin@phe.gov.uk NR 86 TC 7 Z9 8 U1 0 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1052-9276 EI 1099-1654 J9 REV MED VIROL JI Rev. Med. Virol. PD MAR PY 2015 VL 25 IS 2 BP 85 EP 101 DI 10.1002/rmv.1819 PG 17 WC Virology SC Virology GA CD5KY UT WOS:000351127700003 PM 25424978 ER PT J AU Lawson, CC Johnson, CY Chavarro, JE Hibert, EN Whelan, EA Rocheleau, CM Grajewski, B Schernhammer, ES Rich-Edwards, JW AF Lawson, Christina C. Johnson, Candice Y. Chavarro, Jorge E. Hibert, Eileen N. Lividoti Whelan, Elizabeth A. Rocheleau, Carissa M. Grajewski, Barbara Schernhammer, Eva S. Rich-Edwards, Janet W. TI Work schedule and physically demanding work in relation to menstrual function: the Nurses' Health Study 3 SO SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH LA English DT Article DE circadian rhythm; heavy lifting; long work hours; menstrual cycle variation; night shift work; night work; prolonged standing; rotating night shift work; shift work ID POULTRY SLAUGHTERHOUSES; CYCLE LENGTH; BODY-MASS; STRESS; TAIWAN; WOMEN; FECUNDABILITY; PREGNANCY; CANNERIES; PATTERNS AB Objectives This study aimed to evaluate occupational exposures and menstrual cycle characteristics among nurses. Methods Using cross-sectional data collected in 2010-2012 from 6309 nurses aged 21-45 years, we investigated nurses' menstrual function in the Nurses' Health Study 3. We used multivariable regression modeling to analyze the associations between occupational exposures and prevalence of irregular cycles and long and short cycle lengths. Results The cohort reported cycle length as <21 (1.5%), 21-25 (15.6%), 26-31(69.7%), and 32-50(13.2%) days. In addition, 19% of participants reported irregular cycles. Working >= 41 hours/week was associated with a 16% [95% confidence interval (95% CI): 4-29%] higher prevalence of irregular cycles and a higher prevalence of very short (<21-day) cycles [prevalence odds ratio (OR) 1.93,95% CI 1.24-3.01] in adjusted models. Irregular menstrual cycles were more prevalent among women working nights only (32% higher; 95% CI 15-51%) or rotating nights (27% higher, 95% CI 10-47%), and was associated with the number of night shifts per month (P for trend <0.0001). Rotating night schedule was associated with long (32-50 day) cycles (OR 1.28, 95% CI 1.03-1.61). Heavy lifting was associated with a higher prevalence of irregular cycles (34% higher), and the prevalence of cycles <21 days and 21-25 day cycles increased with increasing heavy lifting at work (P for trend <0.02 for each endpoint). Conclusion Night work, long hours, and physically demanding work might relate to menstrual disturbances. C1 [Lawson, Christina C.; Johnson, Candice Y.; Whelan, Elizabeth A.; Rocheleau, Carissa M.; Grajewski, Barbara] NIOSH, Cincinnati, OH 45226 USA. [Johnson, Candice Y.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. [Chavarro, Jorge E.] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. [Chavarro, Jorge E.; Hibert, Eileen N. Lividoti; Schernhammer, Eva S.; Rich-Edwards, Janet W.] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA. [Chavarro, Jorge E.; Hibert, Eileen N. Lividoti; Schernhammer, Eva S.; Rich-Edwards, Janet W.] Harvard Univ, Sch Med, Boston, MA USA. [Chavarro, Jorge E.; Schernhammer, Eva S.; Rich-Edwards, Janet W.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Rich-Edwards, Janet W.] Brigham & Womens Hosp, Connors Ctr Womens Hlth & Gender Biol, Boston, MA 02115 USA. RP Lawson, CC (reprint author), NIOSH, 1090 Tusculum Ave,MS R-15, Cincinnati, OH 45226 USA. EM clawson@cdc.gov FU Centers for Disease Control and Prevention / National Institute for Occupational Safety and Health [200-2013-M-54978]; Breast Cancer Research Foundation FX This work was partially funded by contract number 200-2013-M-54978 to the Brigham and Women's Hospital from the Centers for Disease Control and Prevention / National Institute for Occupational Safety and Health and by the Breast Cancer Research Foundation. NR 33 TC 3 Z9 3 U1 1 U2 5 PU SCANDINAVIAN JOURNAL WORK ENVIRONMENT & HEALTH PI HELSINKI PA TOPELIUKSENKATU 41A, SF-00250 HELSINKI, FINLAND SN 0355-3140 EI 1795-990X J9 SCAND J WORK ENV HEA JI Scand. J. Work Environ. Health PD MAR PY 2015 VL 41 IS 2 BP 194 EP 203 DI 10.5271/sjweh.3482 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CD8GK UT WOS:000351333000009 PM 25634477 ER PT J AU Gibbins, JD MacMahon, K AF Gibbins, John D. MacMahon, Kathleen TI Workplace Safety and Health for the Veterinary Health Care Team SO VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE LA English DT Article DE Occupational safety; Occupational health; Regulations; Needlestick injuries; Hazardous drugs; Animal bites ID NEEDLESTICK INJURIES; BITE; TRANSMISSION; TECHNICIANS; FEVER AB Veterinary clinic employers have a legal and ethical responsibility to provide a safe and healthy workplace. Clinic members are responsible for consistently using safe practices and procedures set up by their employer. Development and implementation of a customized comprehensive workplace safety and health program is emphasized, including an infection control plan. Occupational safety and health regulations are reviewed. The hazards of sharps, animal bites and scratches, and drugs are discussed. Strategies to prevent or minimize adverse health effects and resources for training and education are provided. C1 [Gibbins, John D.] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [MacMahon, Kathleen] NIOSH, Educ & Informat Div, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. RP Gibbins, JD (reprint author), NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Ctr Dis Control & Prevent, 1090 Tusculum Ave,MS R-10, Cincinnati, OH 45226 USA. EM jgibbins@cdc.gov NR 28 TC 0 Z9 0 U1 2 U2 7 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0195-5616 EI 1878-1306 J9 VET CLIN N AM-SMALL JI Vet. Clin. N. Am.-Small Anim. Pract. PD MAR PY 2015 VL 45 IS 2 BP 409 EP + DI 10.1016/j.cvsm.2014.11.006 PG 20 WC Veterinary Sciences SC Veterinary Sciences GA CE1FW UT WOS:000351558500012 PM 25577561 ER PT J AU Yang, H Carney, PJ Chang, JC Guo, Z Villanueva, JM Stevens, J AF Yang, Hua Carney, Paul J. Chang, Jessie C. Guo, Zhu Villanueva, Julie M. Stevens, James TI Structure and receptor binding preferences of recombinant human A(H3N2) virus hemagglutinins SO VIROLOGY LA English DT Article DE Influenza virus; Hemagglutinin; H3N2; Receptor specificity; Glycan microarray ID INFLUENZA-A VIRUS; AMINO-ACID SUBSTITUTIONS; LOWER RESPIRATORY-TRACT; ENVELOPE GLYCOPROTEIN; MONOCLONAL-ANTIBODY; GLYCOSYLATION SITES; POSITIVE SELECTION; ANTIGENIC SITES; MEMBRANE-FUSION; HUMAN AIRWAY AB A(H3N2) influenza viruses have circulated in humans since 1968, and antigenic drift of the hemagglutinin (HA) protein continues to be a driving force that allows the virus to escape the human immune response. Since the major antigenic sites of the HA overlap into the receptor binding site (RBS) of the molecule, the virus constantly struggles to effectively adapt to host immune responses, without compromising its functionality. Here, we have structurally assessed the evolution of the A(H3N2) virus HA RBS, using an established recombinant expression system. Glycan binding specificities of nineteen A (H3N2) influenza virus HAs, each a component of the seasonal influenza vaccine between 1968 and 2012, were analyzed. Results suggest that while its receptor-binding site has evolved from one that can bind a broad range of human receptor analogs to one with a more restricted binding profile for longer glycans, the virus continues to circulate and transmit efficiently among humans. Published by Elsevier Inc. C1 [Yang, Hua; Carney, Paul J.; Chang, Jessie C.; Guo, Zhu; Villanueva, Julie M.; Stevens, James] Ctr Dis Control & Prevent, Influenza Div, NCIRD, Atlanta, GA 30333 USA. RP Stevens, J (reprint author), Ctr Dis Control & Prevent, Influenza Div, NCIRD, 1600 Clifton Rd Mail Stop D-30, Atlanta, GA 30333 USA. FU Centers for Disease Control and Prevention; U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-06CH11357]; DOE Office of Biological and Environmental Research; National Institutes of Health, National Institute of General Medical Sciences [P41GM103393]; National Institute of General Medical Sciences [GM62116] FX This work was funded by the Centers for Disease Control and Prevention. The authors would like to thank the WHO Global Influenza Surveillance and Response System (GISRS), and all submitting laboratories that have deposited their H3N2 HA sequences to the GISAID database. The authors would also like to thank the staff of both SER-CAT sector-22, as well as SSRL BL9-2, for their help for data collection. The U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract no: DE-AC02-06CH11357, support use of the Advanced Photon Source at Argonne National Laboratory. Use of the Stanford Synchrotron Radiation Lightsource, a Directorate of SLAC National Accelerator Laboratory is operated for the U.S. Department of Energy Office of Science by Stanford University and is supported by the DOE Office of Biological and Environmental Research, and by the National Institutes of Health, National Institute of General Medical Sciences (including P41GM103393). The Consortium for Functional Glycomics (CFG) funded by National Institute of General Medical Sciences Grant GM62116, produced Glycan microarrays under contract, for the Centers for Disease Control and Prevention. We also thank the CFG for supplying the biotinylated glycans used here, through their resource request program. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention or the Agency for Toxic Substances and Disease Registry. NR 94 TC 8 Z9 8 U1 1 U2 6 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD MAR PY 2015 VL 477 BP 18 EP 31 DI 10.1016/j.virol.2014.12.024 PG 14 WC Virology SC Virology GA CE0HH UT WOS:000351484600003 PM 25617824 ER PT J AU Pappas, C Yang, H Carney, PJ Pearce, MB Katz, JM Stevens, J Tumpey, TM AF Pappas, Claudia Yang, Hua Carney, Paul J. Pearce, Melissa B. Katz, Jacqueline M. Stevens, James Tumpey, Terrence M. TI Assessment of transmission, pathogenesis and adaptation of H2 subtype influenza viruses in ferrets SO VIROLOGY LA English DT Article DE Influenza; Ferret; Transmission; Hemagglutinin ID RECEPTOR SPECIFICITY; NORTH-AMERICA; AVIAN RESERVOIR; RISK-ASSESSMENT; H5N1 VIRUSES; A VIRUS; HEMAGGLUTININ; SWINE; VIRULENCE; ORIGIN AB After their disappearance from the human population in 1968, influenza H2 viruses have continued to circulate in the natural avian reservoir. The isolation of this virus subtype from multiple bird species as well as swine highlights the need to better understand the potential of these viruses to spread and cause disease in humans. Here we analyzed the virulence, transmissibility and receptor-binding preference of two avian influenza H2 viruses (H2N2 and H2N3) and compared them to a swine H2N3 (A/swine/Missouri/2124514/2006 [swMO]), and a human H2N2 (A/England/10/1967 [Eng/67]) virus using the ferret model as a mammalian host. Both avian H2 viruses possessed the capacity to spread efficiently between cohoused ferrets, and the swine (swMO) and human (Eng/67) viruses transmitted to nave ferrets by respiratory droplets. Further characterization of the swMO hemagglutinin (HA) by x-ray crystallography and glycan microarray array identified receptor-specific adaptive mutations. As influenza virus quasispecies dynamics during transmission have not been well characterized, we sequenced nasal washes collected during transmission studies to better understand experimental adaptation of H2 HA. The avian H2 viruses isolated from ferret nasal washes contained mutations in the HA1, including a Gln226Leu substitution, which is a mutation associated with 2,6 sialic acid (human-like) binding preference. These results suggest that the molecular structure of HA in viruses of the H2 subtype continue to have the potential to adapt to a mammalian host and become transmissible, after acquiring additional genetic markers. Published by Elsevier Inc. C1 [Pappas, Claudia; Yang, Hua; Carney, Paul J.; Pearce, Melissa B.; Katz, Jacqueline M.; Stevens, James; Tumpey, Terrence M.] Ctr Dis Control & Prevent, Influenza Div, NCIRD, Atlanta, GA 30333 USA. RP Tumpey, TM (reprint author), Ctr Dis Control & Prevent, Influenza Div, NCIRD, 1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM tft9@cdc.gov FU Centers for Disease Control and Prevention; National Institute of General Medical Sciences [GM62116] FX This work was funded by the Centers for Disease Control and Prevention. Glycan microarray slides were produced under contract for the Centers for Disease Control and Prevention using a glycan library generously provided by the Consortium for Functional Glycomics (CFG) (www.functionalglycomics.org) funded by National Institute of General Medical Sciences Grant GM62116. We thank the staff of SER-CAT sector 22 for their help with data collection. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention or the Agency for Toxic Substances and Disease Registry. NR 62 TC 3 Z9 4 U1 1 U2 11 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD MAR PY 2015 VL 477 BP 61 EP 71 DI 10.1016/j.virol.2015.01.002 PG 11 WC Virology SC Virology GA CE0HH UT WOS:000351484600007 PM 25659818 ER PT J AU Szilagyi, PG Serwint, JR Humiston, SG Rand, CM Schaffer, S Vincelli, P Dhepyasuwan, N Blumkin, A Albertin, C Curtis, CR AF Szilagyi, Peter G. Serwint, Janet R. Humiston, Sharon G. Rand, Cynthia M. Schaffer, Stanley Vincelli, Phyllis Dhepyasuwan, Nui Blumkin, Aaron Albertin, Christina Curtis, C. Robinette TI Effect of Provider Prompts on Adolescent Immunization Rates: A Randomized Trial SO ACADEMIC PEDIATRICS LA English DT Article DE adolescent immunization; EHR; HPV; influenza; meningococcal; outreach; provider prompt; Tdap ID ELECTRONIC HEALTH RECORD; STATE VACCINATION COVERAGE; AGED 13-17 YEARS; MISSED OPPORTUNITIES; UNITED-STATES; INFLUENZA VACCINATION; DECISION-SUPPORT; CHILDREN; CARE; IMPLEMENTATION AB OBJECTIVE: Adolescent immunization rates are suboptimal. Experts recommend provider prompts at health care visits to improve rates. We assessed the impact of either electronic health record (EHR) or nurse- or staff-initiated provider prompts on adolescent immunization rates. METHODS: We conducted a randomized controlled trial, allocating practices in 1 of 2 practice-based research networks (PBRN) to provider prompts or standard-of-care control. Ten primary care practices participated, 5 intervention and 5 controls, each matched in pairs on urban, suburban, or rural location and practice type (pediatric or family medicine), from a PBRN in Greater Rochester, New York (GR-PBRN); and 12 practices, 6 intervention, 6 controls, similarly matched, from a national pediatric continuity clinic PBRN (CORNET). The study period was 1 year per practice, ranging from June 2011 to January 2013. Study participants were adolescents 11 to 17 years attending these 22 practices; random sample of chart reviews per practice for baseline and postintervention year to assess immunization rates (n = 7,040 total chart reviews for adolescents with >1 visit in a period). The intervention was an EHR prompt (4 GR-PBRN and 5 CORNET practice pairs) (alert) that appeared on providers' computer screens at all office visits, indicating the specific immunizations that adolescents were recommended to receive. Staff prompts (1 GR-PBRN pair and 1 CORNET pair) in the form of a reminder sheet was placed on the provider's desk in the exam room indicating the vaccines due. We compared immunization rates, stratified by PBRN, for routine vaccines (meningococcus, pertussis, human papillomavirus, influenza) at study beginning and end. RESULTS: Intervention and control practices within each PBRN were similar at baseline for demographics and immunization rates. Immunization rates at the study end for adolescents who were behind on immunizations at study initiation were not significantly different for intervention versus control practices for any vaccine or combination of vaccines. Results were similar for each PBRN and also when only EHR-based prompts was assessed. For example, at study end, 3-dose human papillomavirus vaccination rates for GR-PBRN intervention versus control practices were 51% versus 53% (adjusted odds ratio 0.96; 95% confidence interval 0.64-1.34); CORNET intervention versus control rates were 50% versus 42% (adjusted odds ratio 1.06; 95% confidence interval 0.68-1.88). CONCLUSIONS AND RELEVANCE:: In both a local and national setting, provider prompts failed to improve adolescent immunization rates. More rigorous practice-based changes are needed. C1 [Szilagyi, Peter G.; Rand, Cynthia M.; Schaffer, Stanley; Vincelli, Phyllis; Blumkin, Aaron; Albertin, Christina] Univ Rochester, Sch Med & Dent, Dept Pediat, Rochester, NY 14642 USA. [Serwint, Janet R.] Johns Hopkins Univ, Dept Pediat, Baltimore, MD 21218 USA. [Humiston, Sharon G.] Childrens Mercy Hosp & Clin, Dept Pediat, Div Emergency & Urgent Care, Kansas City, MO USA. [Dhepyasuwan, Nui] Acad Pediat Assoc, Atlanta, GA USA. [Curtis, C. Robinette] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Szilagyi, PG (reprint author), Univ Calif Los Angeles, Dept Pediat, 10833 LeConte MC 175217,12-358 MDCC, Los Angeles, CA 90095 USA. EM p_szilagyi@mednet.ucla.edu FU US Centers for Disease Control and Prevention [5U0I1P000312] FX A portion of this paper was presented at the 2014 Pediatric Academic Societies annual meeting, Vancouver, BC, May 3-6, 2014. This study was funded by the US Centers for Disease Control and Prevention (grant 5U0I1P000312). A nonoverlapping portion of the overall study was published in Clinical Pediatrics 2013;52:706-716. We appreciate the collaboration of the physicians and staff at the participating primary care practices. We also appreciate the thoughtful reviewer critiques, which improved the article substantially. NR 35 TC 9 Z9 9 U1 2 U2 10 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1876-2859 EI 1876-2867 J9 ACAD PEDIATR JI Acad. Pediatr. PD MAR-APR PY 2015 VL 15 IS 2 BP 149 EP 157 PG 9 WC Pediatrics SC Pediatrics GA CD0ST UT WOS:000350784900006 PM 25748976 ER PT J AU Bethel, CD Blumberg, SJ Stein, REK Strickland, B Robertson, J Newacheck, PW AF Bethel, Christina D. Blumberg, Stephen J. Stein, Ruth E. K. Strickland, Bonnie Robertson, Julie Newacheck, Paul W. TI Taking Stock of the CSHCN Screener: A Review of Common Questions and Current Reflections SO ACADEMIC PEDIATRICS LA English DT Review DE children with chronic conditions; children with special health care needs; complex CSHCN; Medical Expenditures Panel Survey; National Survey of Children With Special Health Care Needs; National Survey of Children's Health ID HEALTH-CARE NEEDS; IDENTIFYING CHILDREN; NONCATEGORICAL APPROACH; DEFINITION; QUALITY; PREVALENCE; CLASSIFICATION; CHILDHOOD AB Since 2000, the Children with Special Health Care Needs (CSHCN) Screener (CS) has been widely used nationally, by States, and locally as a standardized and brief survey-based method to identify populations of children who experience chronic physical, mental, behavioral, or other conditions and who also require types and amounts of health and related services beyond those routinely used by children. Common questions about the CS include those related to its development and uses; its conceptual framework and potential for under- or overidentification; its ability to stratify CSHCN by complexity of service needs and daily life impacts; and its potential application in clinical settings and comparisons with other identification approaches. This review recaps the development, design, and findings from the use of the CS and synthesizes findings from studies conducted over the past 13 years as well as updated findings on the CS to briefly address the 12 most common questions asked about this tool through technical assistance provided regarding the CS since 2001. Across a range of analyses, the CS consistently identifies a subset of children with chronic conditions who need or use more than a routine type or amount of medical- and health-related services and who share common needs for health care, including care coordination, access to specialized and community-based services, and enhanced family engagement. Scoring algorithms exist to stratify CSHCN by complexity of needs and higher costs of care. Combining CS data with clinical diagnostic code algorithms may enhance capacity to further identify meaningful subgroups. Clinical application is most suited for identifying and characterizing populations of patients and assessing quality and system improvement impacts for children with a broad range of chronic conditions. Other clinical applications require further implementation research. Use of the CS in clinical settings is limited because integration of standardized patient-reported health information is not yet common practice in most settings or in electronic health records. The CS continues to demonstrate validity as a non-condition-specific, population-based tool that addresses many of the limits of condition or diagnosis checklists, including the relatively low prevalence of many individual conditions and substantial within-diagnosis variations and across-diagnoses similarities in health service needs, functioning, and quality of care. C1 [Bethel, Christina D.; Robertson, Julie] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Populat Family & Reprod Hlth, Child & Adolescent Hlth Measurement Initiat, Baltimore, MD 21205 USA. [Blumberg, Stephen J.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, USDHHS, Hyattsville, MD 20782 USA. [Stein, Ruth E. K.] Albert Einstein Coll Med, Bronx, NY 10467 USA. [Stein, Ruth E. K.] Childrens Hosp Montefiore, Bronx, NY USA. [Strickland, Bonnie] Maternal & Child Hlth Bur, USDHHS, Hlth Resources & Serv Adm, Dockville, MD USA. [Newacheck, Paul W.] Univ Calif San Francisco, Philip R Lee Inst Hlth Policy Studies, San Francisco, CA 94143 USA. RP Bethel, CD (reprint author), Johns Hopkins Univ, Johns Hopkins Bloomberg Sch Publ Hlth, Dept Populat Family & Reprod Hlth, 615 N Wolfe St,Room E4152, Baltimore, MD 21205 USA. EM cbethell@jhu.edu FU Child and Adolescent Health Measurement Initiative; National Data Resource Center for Child and Adolescent Health - federal Maternal and Child Health Bureau [1-U59-MC06980-01] FX Supported through the Child and Adolescent Health Measurement Initiative and the National Data Resource Center for Child and Adolescent Health, funded by the federal Maternal and Child Health Bureau through Cooperative Agreement 1-U59-MC06980-01. The views expressed in this report are those of the authors and do not necessarily represent those of the Health Resources and Services Administration or the US Centers for Disease Control and Prevention/National Center for Health Statistics. The authors thank Narangeral Gombojav, PhD, for periodic data analysis assistance. NR 68 TC 11 Z9 11 U1 1 U2 8 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1876-2859 EI 1876-2867 J9 ACAD PEDIATR JI Acad. Pediatr. PD MAR-APR PY 2015 VL 15 IS 2 BP 165 EP 176 DI 10.1016/j.acap.2014.10.003 PG 12 WC Pediatrics SC Pediatrics GA CD0ST UT WOS:000350784900008 PM 25486969 ER PT J AU Freedman, DS Ford, ES AF Freedman, David S. Ford, Earl S. TI Are the recent secular increases in the waist circumference of adults independent of changes in BMI? SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article DE BMI; abdominal obesity; secular trends; waist circumference; panel design; adults; NHANES; obesity ID BODY-MASS INDEX; POISSON REGRESSION APPROACH; X-RAY ABSORPTIOMETRY; ABDOMINAL OBESITY; US ADULTS; CARDIOVASCULAR-DISEASE; CARDIOMETABOLIC RISK; METABOLIC SYNDROME; ENGLISH ADULTS; UNITED-STATES AB Background: Several studies showed that the waist circumference of US adults has increased over the past 25 y. However, because of the high correlation between waist circumference and body mass index (BMI; in kg/m(2)) (r similar to 0.9), it is uncertain if these trends in waist circumference exceed those expected on the basis of BMI changes over this time period. Objective: We assessed whether the recent trend in waist circumference was independent of changes in BMI, age, and race-ethnicity. Design: We analyzed data from the 1999-2000 through 2011-2012 cycles of the NHANES. Results: The mean waist circumference increased by 2 cm (in men) and 4 cm (in women) in adults in the United States over this 12-y period. In men, this increase was very close to what would be expected because of the 0.7 increase in mean BMI over this period. However, in women, most of the secular increase in waist circumference appeared to be independent of changes in BMI (mean: 0.6), age, and race-ethnicity over the 12-y period. We estimated that, independent of changes in these covariates, the mean waist circumference increased by 0.2 cm in men and 2.4 cm in women from 1999-2000 through 2011-2012; only the latter estimate was statistically significant. Conclusions: Our results indicate that, in women but not men, the recent secular trend in waist circumference is greater than what would be expected on the basis of changes in BMI. Possible reasons for this secular increase, along with sex differences, are uncertain. C1 [Freedman, David S.] CDC, Div Nutr Phys Act & Obes, Atlanta, GA 30333 USA. [Ford, Earl S.] CDC, Div Adult & Community Hlth, Atlanta, GA 30333 USA. RP Freedman, DS (reprint author), CDC F-77,4770 Buford Highway, Atlanta, GA 30341 USA. EM dxf1@cdc.gov FU Intramural CDC HHS [CC999999] NR 52 TC 10 Z9 10 U1 0 U2 6 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0002-9165 EI 1938-3207 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD MAR PY 2015 VL 101 IS 3 BP 425 EP 431 DI 10.3945/ajcn.114.094672 PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA CC7HR UT WOS:000350538800004 PM 25733625 ER PT J AU Ahuja, JKC Pehrsson, PR Haytowitz, DB Wasswa-Kintu, S Nickle, M Showell, B Thomas, R Roseland, J Williams, J Khan, M Nguyen, Q Hoy, K Martin, C Rhodes, D Moshfegh, A Gillespie, C Gunn, J Merritt, R Cogswell, M AF Ahuja, Jaspreet K. C. Pehrsson, Pamela R. Haytowitz, David B. Wasswa-Kintu, Shirley Nickle, Melissa Showell, Bethany Thomas, Robin Roseland, Janet Williams, Juhi Khan, Mona Quynhanh Nguyen Hoy, Kathy Martin, Carrie Rhodes, Donna Moshfegh, Alanna Gillespie, Cathleen Gunn, Janelle Merritt, Robert Cogswell, Mary TI Sodium monitoring in commercially processed and restaurant foods SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article DE USDA National Nutrient Database for Standard Reference (SR); United States; monitoring; sodium; sodium reduction; commercially processed foods; restaurant foods ID NUTRIENT ANALYSIS PROGRAM; USDAS NATIONAL FOOD; UNITED-STATES AB Background: Most sodium in the US diet comes from commercially processed and restaurant foods. Sodium reduction in these foods is key to several recent public health efforts. Objective: The objective was to provide an overview of a program led by the USDA, in partnership with other government agencies, to monitor sodium contents in commercially processed and restaurant foods in the United States. We also present comparisons of nutrients generated under the program to older data. Design: We track similar to 125 commercially processed and restaurant food items ("sentinel foods") annually using information from food manufacturers and periodically by nationwide sampling and laboratory analyses. In addition, we monitor >1100 other commercially processed and restaurant food items, termed "priority-2 foods" (P2Fs) biennially by using information from food manufacturers. These foods serve as indicators for assessing changes in the sodium content of commercially processed and restaurant foods in the United States. We sampled all sentinel foods nationwide and reviewed all P2Fs in 2010-2013 to determine baseline sodium concentrations. Results: We updated sodium values for 73 sentinel foods and 551 P2Fs in the USDA's National Nutrient Database for Standard Reference (releases 23-26). Sodium values changed by at least 10% for 43 of the sentinel foods, which, for 31 foods, including commonly consumed foods such as bread, tomato catsup, and potato chips, the newer sodium values were lower. Changes in the concentrations of related nutrients (total and saturated fat, total sugar, potassium, or dietary fiber) that were recommended by the 2010 Dietary Guidelines for Americans for reduced or increased consumption accompanied sodium reduction. The results of sodium reduction efforts, based on resampling of the sentinel foods or re-review of P2Fs, will become available beginning in 2015. Conclusion: This monitoring program tracks sodium reduction efforts, improves food composition databases, and strengthens national nutrition monitoring. C1 [Ahuja, Jaspreet K. C.; Pehrsson, Pamela R.; Haytowitz, David B.; Wasswa-Kintu, Shirley; Nickle, Melissa; Showell, Bethany; Thomas, Robin; Roseland, Janet; Williams, Juhi; Khan, Mona; Quynhanh Nguyen; Hoy, Kathy; Martin, Carrie; Rhodes, Donna; Moshfegh, Alanna] USDA ARS, Beltsville Human Nutr Res Ctr, Beltsville, MD USA. [Gillespie, Cathleen; Gunn, Janelle; Merritt, Robert; Cogswell, Mary] CDC, Atlanta, GA 30333 USA. RP Ahuja, JKC (reprint author), 10300 Baltimore Ave,Bldg 005,Room 205 BARC WEST, Beltsville, MD 20705 USA. EM jaspreet.ahuja@ars.usda.gov FU CDC-USDA [60-1235-0-185] FX Supported in part by CDC-USDA agreement 60-1235-0-185. NR 37 TC 7 Z9 8 U1 1 U2 10 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0002-9165 EI 1938-3207 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD MAR PY 2015 VL 101 IS 3 BP 622 EP 631 DI 10.3945/ajcn.114.084954 PG 10 WC Nutrition & Dietetics SC Nutrition & Dietetics GA CC7HR UT WOS:000350538800027 PM 25733648 ER PT J AU Lowe, BD Swanson, NG Hudock, SD Lotz, WG AF Lowe, Brian D. Swanson, Naomi G. Hudock, Stephen D. Lotz, W. Gregory TI Unstable Sitting in the Workplace-Are There Physical Activity Benefits? SO AMERICAN JOURNAL OF HEALTH PROMOTION LA English DT Article ID ENERGY-EXPENDITURE; MUSCLE ACTIVATION; EXERCISE BALL; OFFICE CHAIR; WORK AB The increasingly popular practice of using a stability ball (exercise/fitness ball) as a sitting surface runs counter to conventional human factors/ergonomics guidelines for seated workspace design. Employees sitting on stability balls in an office environment present safety risks that might be justifiable if the practice has a definitive benefit to the promotion of health. However, the published studies and best evidence to date call into question even the theoretical basis for this practice and do not suggest significant health benefits. First, biomechanical studies do not confirm the intended trunk muscle activation. Second, energy expenditure studies show a small (if any) increase in metabolic demand that is unlikely to be effective in combating sedentary work risk factors. Until studies demonstrate more conclusive benefits, the practice of stability ball sitting should be viewed skeptically as a general workplace recommendation in the interest of health or wellness. C1 [Lowe, Brian D.; Swanson, Naomi G.; Hudock, Stephen D.; Lotz, W. Gregory] NIOSH, Div Appl Res & Technol, Cincinnati, OH 45226 USA. RP Lowe, BD (reprint author), NIOSH, Div Appl Res & Technol, 1090 Tusculum Ave,MS C-24, Cincinnati, OH 45226 USA. EM blowe@cdc.gov FU Intramural CDC HHS [CC999999] NR 15 TC 1 Z9 1 U1 2 U2 31 PU AMER JOURNAL HEALTH PROMOTION INC PI TROY PA PO BOX 1254, TROY, MI 48099-1254 USA SN 0890-1171 EI 2168-6602 J9 AM J HEALTH PROMOT JI Am. J. Health Promot. PD MAR-APR PY 2015 VL 29 IS 4 BP 207 EP 209 DI 10.4278/ajhp.140331-CIT-127 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CC7HH UT WOS:000350537800002 PM 25723382 ER PT J AU Kumar, G Park, S Onufrak, S AF Kumar, Gayathri Park, Sohyun Onufrak, Stephen TI Perceptions About Energy Drinks Are Associated With Energy Drink Intake Among US Youth SO AMERICAN JOURNAL OF HEALTH PROMOTION LA English DT Article DE Energy Drinks; Adolescents; Perceptions; Consumption; Sugar-Sweetened Beverages; Prevention Research ID COLLEGE-STUDENTS; ADOLESCENTS; CHILDREN; CONSUMPTION; HEALTH AB Purpose. Energy drinks are growing in popularity among youth because of their stimulant properties. However, they can increase blood pressure and are associated with serious consequences such as cardiac arrest. This study examined the associations between energy drink perceptions and energy drink consumption among youth. Design. The design was a cross-sectional study using the YouthStyles Survey 2011. Setting. The online survey was administered at home. Subjects. Subjects were youths aged 12 to 17 years in the summer of 2011 (n = 779). Measures. Energy drink consumption, perceptions about energy drinks, and sociodemographic and behavioral variables were measured. Analysis. Chi-square and multivariable logistic regression analyses were used. Results. Overall, 9% of youth drank energy drinks, 19.5% agreed that energy drinks are safe drinks for teens, and 12.5% agreed that energy drinks are a type of sports drink. The proportion of youth consuming energy drinks once per week or more was highest among youth aged 16 to 17 years and among those who are physically active three to six times a week. The odds for drinking energy drinks once per week or more was higher among youth who agreed that energy drinks are safe drinks for teens (odds ratios [OR] = 7.7, 95% confidence intervals [CI] =3.6, 16.4) and among those who agreed that energy drinks are a type of sports drink (OR = 5.0, 95% CI = 2.4, 10.7). Conclusions. These findings suggest that many youth may be unaware or misinformed about the potential health effects and nutritional content of energy drinks. Efforts to improve education among youth about the potential adverse effects of consuming energy drinks are needed. C1 [Kumar, Gayathri] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Surveillance Epidemiol & Lab Serv, Atlanta, GA 30341 USA. [Park, Sohyun; Onufrak, Stephen] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Kumar, G (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Surveillance Epidemiol & Lab Serv, 4770 Buford Highway, Atlanta, GA 30341 USA. EM wiz3@cdc.gov NR 27 TC 1 Z9 2 U1 1 U2 13 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0890-1171 EI 2168-6602 J9 AM J HEALTH PROMOT JI Am. J. Health Promot. PD MAR-APR PY 2015 VL 29 IS 4 BP 238 EP 244 DI 10.4278/ajhp.130820-QUAN-435 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CC7HH UT WOS:000350537800007 PM 24460002 ER PT J AU Kane, H Strazza, K Losby, JL Lane, R Mugavero, K Anater, AS Frost, C Margolis, M Hersey, J AF Kane, Heather Strazza, Karen Losby, Jan L. Lane, Rashon Mugavero, Kristy Anater, Andrea S. Frost, Corey Margolis, Marjorie Hersey, James TI Lessons Learned From Community-Based Approaches to Sodium Reduction SO AMERICAN JOURNAL OF HEALTH PROMOTION LA English DT Article DE Sodium Reduction; Nutrition; Case Study; Prevention Research AB Purpose. This article describes lessons from a Centers for Disease Control and Prevention initiative encompassing sodium reduction interventions in six communities. Design. A multiple case study design was used. Setting. This evaluation examined data from programs implemented in six communities located in New York (Broome County, Schenectady County, and New York City); California (Los Angeles County and Shasta County); and Kansas (Shawnee County). Subjects. Participants (n=80) included program staff program directors, state-level staff and partners. Measures. Measures for this evaluation included challenges, facilitators, and lessons learned from implementing sodium reduction strategies. Analysis. The project team conducted a document review of program materials and semistructured interviews 12 to 14 months after implementation. The team coded and analyzed data deductively and inductively. Results. Five lessons for implementing community-based sodium reduction approaches emerged: (1) build relationships with partners to understand their concerns, (2) involve individuals knowledgeable about specific venues early, (3) incorporate sodium reduction efforts and messaging into broader nutrition efforts, (4) design the program to reduce sodium gradually to take into account consumer preferences and taste transitions, and (5) identify ways to address the cost of lower-sodium products. Conclusion. The experiences of the six communities may assist practitioners in planning community-based sodium reduction interventions. Addressing sodium reduction using a community-based approach can foster meaningful change in dietary sodium consumption. C1 [Kane, Heather; Strazza, Karen; Anater, Andrea S.; Frost, Corey; Margolis, Marjorie; Hersey, James] RTI Int, Durham, NC 27709 USA. [Losby, Jan L.; Lane, Rashon; Mugavero, Kristy] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA USA. RP Kane, H (reprint author), RTI Int, 3040 Cornwallis Rd, Durham, NC 27709 USA. EM hkane@rti.org FU Centers for Disease Control and Prevention [DP10-1019] FX The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. This work has been funded by the Centers for Disease Control and Prevention (Cooperative Agreement DP10-1019). NR 8 TC 0 Z9 0 U1 0 U2 4 PU AMER JOURNAL HEALTH PROMOTION INC PI TROY PA PO BOX 1254, TROY, MI 48099-1254 USA SN 0890-1171 EI 2168-6602 J9 AM J HEALTH PROMOT JI Am. J. Health Promot. PD MAR-APR PY 2015 VL 29 IS 4 BP 255 EP 258 DI 10.4278/ajhp.121012-ARB-501 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CC7HH UT WOS:000350537800009 PM 24575726 ER PT J AU Pazol, K Whiteman, MK Folger, SG Kourtis, AP Marchbanks, PA Jamieson, DJ AF Pazol, Karen Whiteman, Maura K. Folger, Suzanne G. Kourtis, Athena P. Marchbanks, Polly A. Jamieson, Denise J. TI Sporadic contraceptive use and nonuse: age-specific prevalence and associated factors SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE adolescent; age difference; contraceptive counseling; perimenopause ID UNITED-STATES; UNINTENDED PREGNANCY; ADULT WOMEN; DISCONTINUATION; YOUNG; RISK; SURVEILLANCE; REASONS AB OBJECTIVE: The purpose of this study was to characterize age-group specific patterns in the stability of contraceptive use and to evaluate whether factors that are associated with nonuse and sporadic use, compared with stable use, differ by age among women who are at risk for unintended pregnancy. STUDY DESIGN: We used data from the 2006-2010 National Survey of Family Growth to characterize the prevalence of stable and sporadic contraceptive use and nonuse by age over a 1-year period. We used polytomous logistic regression models to assess the odds of contraceptive nonuse and sporadic use vs stable use. Age-stratified models were used to show age-group differences in associated characteristics. RESULTS: Over a 1-year period, stable contraceptive use decreased across age groups from 80% for teens 15-19 years old to 74% for women 20-24 years old, and 70-71% for women 25-34 and 35-44 years old. Contraceptive nonuse increased across age groups from 5% for teens 15-19 years old to 9-20% for older women. By contrast, sporadic use was least common for women 35-44 years old (10% compared with 16-17% for younger women). Among teens 15-19 years old, a history of method discontinuation because of dissatisfaction was associated with nonuse. Among older women, intentions to have children in the future and reported difficulty achieving pregnancy were associated with nonuse and sporadic use. CONCLUSION: Because the stability of contraceptive use and associated factors differ by age, providers may need to consider these differences when talking to women about contraception. To address nonuse, helping teens identify a method that they are comfortable using may be especially important; for older women, discussing the potential for continuing fertility may be more important. To address sporadic use, discussing the benefits of user-independent methods may be helpful, with a particular emphasis on long-acting reversible contraceptives for younger women and teens who are less likely to have completed their desired childbearing and who have tended to rely on methods that are more difficult to use consistently. C1 [Pazol, Karen; Whiteman, Maura K.; Folger, Suzanne G.; Kourtis, Athena P.; Marchbanks, Polly A.; Jamieson, Denise J.] Ctr Dis Control & Prevent, Womens Hlth & Fertil Branch, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. RP Pazol, K (reprint author), Ctr Dis Control & Prevent, Womens Hlth & Fertil Branch, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. EM kpazol@cdc.gov FU Intramural CDC HHS [CC999999] NR 40 TC 1 Z9 1 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 EI 1097-6868 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD MAR PY 2015 VL 212 IS 3 AR 324.e1 DI 10.1016/j.ajog.2014.10.004 PG 8 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA CC5DC UT WOS:000350377500015 PM 25305406 ER PT J AU Flegal, KM Panagiotou, OA Graubard, BI AF Flegal, Katherine M. Panagiotou, Orestis A. Graubard, Barry I. TI Estimating population attributable fractions to quantify the health burden of obesity SO ANNALS OF EPIDEMIOLOGY LA English DT Article DE Body mass index; Obesity; Body weight; Epidemiologic methods; Risk ID BODY-MASS INDEX; TYPE-2 DIABETES-MELLITUS; CORONARY-HEART-DISEASE; RISK-FACTORS; UNITED-STATES; LIFE-STYLE; PROSPECTIVE COHORT; CANCER INCIDENCE; EXCESS WEIGHT; ATHEROSCLEROSIS RISK AB Purpose: Obesity is a highly prevalent condition in the United States and elsewhere and is associated with increased mortality and morbidity. Here, we discuss some issues involved in quantifying the health burden of obesity using population attributable fraction (PAF) estimates and provide examples. Methods: We searched PubMed for articles reporting attributable fraction estimates for obesity. We reviewed eligible articles to identify methodological concerns and tabulated illustrative examples of PAF estimates for obesity relative to cancer, diabetes, cardiovascular disease, and all-cause mortality. Results: There is considerable variability among studies regarding the methods used for PAF calculation and the selection of appropriate counterfactuals. The reported estimates ranged from 5% to 15% for all-cause mortality, -0.2% to 8% for all-cancer incidence, 7% to 44% for cardiovascular disease incidence, and 3% to 83% for diabetes incidence. Conclusions: To evaluate a given estimate, it is important to consider whether the exposure and outcome were defined similarly for the PAF and for the relative risks, whether the relative risks were suitable for the population at hand, and whether PAF was calculated using correct methods. Strong causal assumptions are not necessarily warranted. In general, PAFs for obesity may be best considered as indicators of association. Published by Elsevier Inc. C1 [Flegal, Katherine M.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Panagiotou, Orestis A.; Graubard, Barry I.] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. RP Flegal, KM (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, 3311 Toledo Rd,Room 4336, Hyattsville, MD 20782 USA. EM kmf2@cdc.gov RI Panagiotou, Orestis/I-5934-2015; OI Panagiotou, Orestis/0000-0001-9604-8380; Flegal, Katherine/0000-0002-0838-469X FU Intramural NIH HHS [Z99 CA999999] NR 90 TC 10 Z9 10 U1 1 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1047-2797 EI 1873-2585 J9 ANN EPIDEMIOL JI Ann. Epidemiol. PD MAR PY 2015 VL 25 IS 3 BP 201 EP 207 DI 10.1016/j.annepidem.2014.11.010 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CD0RQ UT WOS:000350782000010 PM 25511307 ER PT J AU Prybylski, D Manopaiboon, C Visavakum, P Yongvanitjit, K Aramrattana, A Manomaipiboon, P Tanpradech, S Suksripanich, O Pattanasin, S Wolfe, M Whitehead, SJ AF Prybylski, Dimitri Manopaiboon, Chomnad Visavakum, Prin Yongvanitjit, Kovit Aramrattana, Apinun Manomaipiboon, Parnrudee Tanpradech, Suvimon Suksripanich, Orapin Pattanasin, Sarika Wolfe, Mitchell Whitehead, Sara J. TI Diverse HIV epidemics among people who inject drugs in Thailand: Evidence from respondent-driven sampling surveys in Bangkok and Chiang Mai SO DRUG AND ALCOHOL DEPENDENCE LA English DT Article DE People who inject drugs; HIV; Risk behaviors; Respondent-driven sampling; Thailand ID HIDDEN POPULATIONS; NORTHERN THAILAND; VACCINE TRIAL; EAST-ASIA; USERS; METHAMPHETAMINE; PREVALENCE; POLICE; TRENDS; RISKS AB Background: Thailand's long-standing HIV sero-sentinel surveillance system for people who inject drugs (PWID) is confined to those in methadone-based drug treatment clinics and representative data are scarce, especially outside of Bangkok. Methods: We conducted probability-based respondent-driven sampling (RDS) surveys in Bangkok (n = 738) and Chiang Mai (n = 309) to increase understanding of local HIV epidemics and to better inform the planning of evidence-based interventions. Results: PWID had different epidemiological profiles in these two cities. Overall HIV prevalence was higher in Bangkok (23.6% vs. 10.9%, p < 0.001) but PWID in Bangkok are older and appear to have long-standing HIV infections. In Chiang Mai, HIV infections appear to be more recently acquired and PWID were younger and had higher levels of recent injecting and sexual risk behaviors with lower levels of intervention exposure. Methamphetamine was the predominant drug injected in both sites and polydrug use was common although levels and patterns of the specific drugs injected varied significantly between the sites. In multivariate analysis, recent midazolam injection was significantly associated with HIV infection in Chiang Mai (adjusted odds ratio = 8.1; 95% confidence interval: 1.2-54.5) whereas in Bangkok HIV status was not associated with recent risk behaviors as infections had likely been acquired in the past. Conclusion: PWID epidemics in Thailand are heterogeneous and driven by local factors. There is a need to customize intervention strategies for PWID in different settings and to integrate population-based survey methods such as RDS into routine surveillance to monitor the national response. Published by Elsevier Ireland Ltd. C1 [Prybylski, Dimitri; Manopaiboon, Chomnad; Visavakum, Prin; Tanpradech, Suvimon; Suksripanich, Orapin; Pattanasin, Sarika; Wolfe, Mitchell; Whitehead, Sara J.] Thailand MOPH US CDC Collaborat, Nonthaburi 11000, Thailand. [Prybylski, Dimitri; Wolfe, Mitchell; Whitehead, Sara J.] Ctr Dis Control & Prevent, Div Global HIV AIDS, Atlanta, GA 30333 USA. [Yongvanitjit, Kovit; Manomaipiboon, Parnrudee] Bangkok Metropolitan Adm, Bangkok 10200, Thailand. [Aramrattana, Apinun] Res Inst Hlth Sci, Chiang Mai, Thailand. RP Prybylski, D (reprint author), Minist Publ Hlth, Thailand MOPH US CDC Collaborat, DDC 7 Bldg,5th Floor, Nonthaburi 11000, Thailand. EM hjt1@cdc.gov FU President's Emergency Plan for AIDS Relief (PEPFAR) through U.S. Centers for Disease Control and Prevention (CDC) [5U19GH000002] FX This research has been supported by the President's Emergency Plan for AIDS Relief (PEPFAR) through U.S. Centers for Disease Control and Prevention (CDC) Cooperative Agreement Grant 5U19GH000002. NR 40 TC 3 Z9 3 U1 0 U2 2 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0376-8716 EI 1879-0046 J9 DRUG ALCOHOL DEPEN JI Drug Alcohol Depend. PD MAR 1 PY 2015 VL 148 BP 126 EP 135 DI 10.1016/j.drugalcdep.2014.12.034 PG 10 WC Substance Abuse; Psychiatry SC Substance Abuse; Psychiatry GA CC7DF UT WOS:000350527200016 PM 25640153 ER PT J AU Karim, MR Wang, RJ Yu, FC Li, TY Dong, HJ Li, DZ Zhang, LX Li, JQ Jian, FC Zhang, SM Rume, FI Ning, CS Xiao, LH AF Karim, Md Robiul Wang, Rongjun Yu, Fuchang Li, Tongyi Dong, Haiju Li, Dezhong Zhang, Longxian Li, Junqiang Jian, Fuchun Zhang, Sumei Rume, Farzana Islam Ning, Changshen Xiao, Lihua TI Multi-locus analysis of Giardia duodenalis from nonhuman primates kept in zoos in China: Geographical segregation and host-adaptation of assemblage B isolates SO INFECTION GENETICS AND EVOLUTION LA English DT Article DE Giardia duodenalis; Multi-locus analysis; Nonhuman primates; China ID ENTEROCYTOZOON-BIENEUSI; MOLECULAR EPIDEMIOLOGY; ZOONOTIC TRANSMISSION; CRYPTOSPORIDIUM SPP.; WESTERN UGANDA; GENOTYPES; CHILDREN; IDENTIFICATION; INFECTIONS; PREVALENCE AB Only a few studies based on single locus characterization have been conducted on the molecular epidemiology of Giardia duodenalis in nonhuman primates (NHPs). The present study was conducted to examine the occurrence and genotype identity of G. duodenalis in NHPs based on multi-locus analysis of the small-subunit ribosomal RNA (SSU rRNA), triose phosphate isomerase (tpi), glutamate dehydrogenase (gdh), and beta-giardin (bg) genes. Fecal specimens were collected from 496 animals of 36 NHP species kept in seven zoos in China and screened for G. duodenalis by tpi-based PCR. G. duodenalis was detected in 92(18.6%) specimens from 18 NHP species, belonging to assemblage A (n = 4) and B (n = 88). In positive NHP species, the infection rates ranged from 4.8% to 100%. In tpi sequence analysis, the assemblage A included subtypes A1, A2 and one novel subtype. Multi-locus analysis of the tpi, gdh, and bg genes detected 11 (8 known and 3 new), 6 (3 known and 3 new) and 9 (2 known and 7 new) subtypes in 88, 47 and 35 isolates in assemblage B, respectively. Thirty-two assemblage B isolates with data at all three loci yielded 15 multi-locus genotypes (MLGs), including 2 known and 13 new MLGs. Phylogenetic analysis of concatenated sequences of assemblage B showed that MLGs found here were genetically different from those of humans. NHPs, rabbit and guinea pig in Italy and Sweden. It further indicated that assemblage B isolates in ring-tailed lemurs and squirrel monkeys might be genetically different from those in other NHPs. These data suggest that NHPs are mainly infected with G. duodenalis assemblage B and there might be geographical segregation and host-adaptation in assemblage B in NHPs. (C) 2014 Elsevier B.V. All rights reserved. C1 [Karim, Md Robiul; Wang, Rongjun; Yu, Fuchang; Dong, Haiju; Zhang, Longxian; Li, Junqiang; Jian, Fuchun; Zhang, Sumei; Ning, Changshen] Henan Agr Univ, Coll Anim Sci & Vet Med, Zhengzhou 450002, Peoples R China. [Li, Tongyi; Li, Dezhong] Zhengzhou Zoo, Zhengzhou 45000, Peoples R China. [Rume, Farzana Islam] Patuakhali Sci & Technol Univ, Dept Microbiol, Patuakhali 8602, Bangladesh. [Xiao, Lihua] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA. RP Zhang, LX (reprint author), Henan Agr Univ, Coll Anim Sci & Vet Med, Zhengzhou 450002, Peoples R China. EM zhanglx8999@gmail.com; lxiao@cdc.gov RI Xiao, Lihua/B-1704-2013; OI Xiao, Lihua/0000-0001-8532-2727; zhang, longxian/0000-0002-5706-131X FU Key Program of National Natural Science Foundation of China [31330079]; Innovative Scientists Cultivation Projects of Henan Province [134200510012]; National Science and Technology Major Project [2012ZX10004220]; Program for Science and Technology Innovative Research Team at Universities in Henan Province [012IRTSTHN005] FX This study was supported in part by the Key Program of National Natural Science Foundation of China (31330079), Innovative Scientists Cultivation Projects of Henan Province (134200510012), National Science and Technology Major Project (No. 2012ZX10004220), Program for Science and Technology Innovative Research Team at Universities in Henan Province (012IRTSTHN005). NR 46 TC 8 Z9 9 U1 0 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1567-1348 EI 1567-7257 J9 INFECT GENET EVOL JI Infect. Genet. Evol. PD MAR PY 2015 VL 30 BP 82 EP 88 DI 10.1016/j.meegid.2014.12.013 PG 7 WC Infectious Diseases SC Infectious Diseases GA CC7CN UT WOS:000350525400012 PM 25530435 ER PT J AU Gerding, DN Lessa, FC AF Gerding, Dale N. Lessa, Fernanda C. TI The Epidemiology of Clostridium difficile Infection Inside and Outside Health Care Institutions SO INFECTIOUS DISEASE CLINICS OF NORTH AMERICA LA English DT Article DE Clostridium difficile infection; Community associated; Health care associated; Risk factors; Strain type ID MOLECULAR EPIDEMIOLOGY; MONROE COUNTY; RISK-FACTORS; STRAIN TYPE; NEW-YORK; COMMUNITY; DISEASE; DIARRHEA; COLONIZATION; COLITIS AB This article describes the global changes in Clostridium difficile epidemiology since the late twentieth century and into the twenty-first century when the new epidemic strain BI/NAP1/027 emerged. The article provides an overview of how understanding of C difficile epidemiology has rapidly evolved since its initial association with colitis in 1974. It also discusses how C difficile has spread across the globe, the role of asymptomatic carriers in disease transmission, the increased recognition of C difficile outside health care settings, the changes in epidemiology of C difficile infection in children, and the risk factors for disease. C1 [Gerding, Dale N.] Loyola Univ Chicago, Stritch Sch Med, Dept Med, Maywood, IL 60153 USA. [Gerding, Dale N.] Edward Hines Jr Vet Affairs Hosp, Res Serv, Hines, IL 60141 USA. [Lessa, Fernanda C.] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Healthcare Qual Promot, Atlanta, GA 30329 USA. RP Gerding, DN (reprint author), Loyola Univ Chicago, Stritch Sch Med, Dept Med, 2160 S 1st Ave, Maywood, IL 60153 USA. EM dale.gerding2@va.gov NR 85 TC 12 Z9 12 U1 1 U2 8 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0891-5520 EI 1557-9824 J9 INFECT DIS CLIN N AM JI Infect. Dis. Clin. North Am. PD MAR PY 2015 VL 29 IS 1 BP 37 EP + DI 10.1016/j.idc.2014.11.004 PG 16 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CD3YU UT WOS:000351020600005 PM 25582647 ER PT J AU Ricks, PM Hershow, RC Rahimian, A Huo, D Johnson, W Prachand, N Jimenez, A Wiebel, W Paul, W AF Ricks, P. M. Hershow, R. C. Rahimian, A. Huo, D. Johnson, W. Prachand, N. Jimenez, A. Wiebel, W. Paul, W. TI A randomized trial comparing standard outcomes in two treatment models for substance users with tuberculosis SO INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE LA English DT Article DE compliance; adherence; hard-to-reach populations; indigenous leadership ID DIRECTLY OBSERVED THERAPY; RISK; NONCOMPLIANCE; INCENTIVES; ADHERENCE; CITY AB SETTING: Chicago Department of Public Health (CDPH), TB Control Program. OBJECTIVES: To compare anti-tuberculosis treatment outcomes using two different types of directly observed therapy (DOT) outreach workers. METHODS: Substance users diagnosed with TB from October 1996 to July 2000 were randomized to DOT administered by either 1) CDPH personnel (standard arm) or 2) previous substance-using human immunodeficiency virus/acquired immune-deficiency syndrome outreach workers (enhanced arm). Treatment completion was physician-determined, and adherence was estimated based on risk of missed DOT appointments. RESULTS: Of 94 patients, 46 were randomized to the standard and 48 to the enhanced arm. The standard arm had a significantly higher risk of non-completion of treatment (39% vs. 15%, RR 2.7, 95%CI 1.2-5.8), and a significantly higher risk of missing DOT appointments (RR 2.6, 95%CI 1.4-4.8). For both outcomes, housing instability was a significant predictor in multivariate analyses. CONCLUSIONS: TB treatment completion and adherence among substance users was improved by the enhanced intervention; the familiarity of enhanced-arm DOT workers with the patients' social norms due to their own previous substance use may have made them more effective. Successful DOT in hard-to-reach populations may require strategies that directly address the population's circumstances and utilize DOT workers who are intimately familiar with patients' life situations. C1 [Ricks, P. M.; Hershow, R. C.; Jimenez, A.; Wiebel, W.] Univ Illinois, Sch Publ Hlth, Chicago, IL USA. [Huo, D.] Univ Chicago, Dept Hlth Studies, Chicago, IL 60637 USA. [Johnson, W.] Georgia Perimeter Coll, Fairburn, GA USA. [Prachand, N.] Chicago Dept Publ Hlth, Chicago, IL USA. [Paul, W.] Metro Publ Hlth Dept Nashville Davidson Cty, Nashville, TN USA. RP Ricks, PM (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, 1600 Clifton Rd NE,MS A-06, Atlanta, GA 30333 USA. EM hgp4@cdc.gov FU National Heart, Lung and Blood Institute of the National Institutes of Health, Bethesda, MD, USA [R01 HL55760-04] FX This research was funded by a grant from the National Heart, Lung and Blood Institute of the National Institutes of Health, Bethesda, MD, USA (# R01 HL55760-04). NR 29 TC 1 Z9 1 U1 0 U2 1 PU INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) PI PARIS PA 68 BOULEVARD SAINT-MICHEL,, 75006 PARIS, FRANCE SN 1027-3719 EI 1815-7920 J9 INT J TUBERC LUNG D JI Int. J. Tuberc. Lung Dis. PD MAR PY 2015 VL 19 IS 3 BP 326 EP 332 DI 10.5588/ijtld.14.0471 PG 7 WC Infectious Diseases; Respiratory System SC Infectious Diseases; Respiratory System GA CC9SO UT WOS:000350711700017 PM 25686142 ER PT J AU Hoger, S Lykens, K Beavers, S Katz, D Miller, T AF Hoger, Sally Lykens, Kristine Beavers, Suzanne Katz, Dolly Miller, Thaddeus CA TB Epidemiologic Studies TI Regarding the effect of cured tuberculosis disease on longevity Reply SO INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE LA English DT Letter ID QUALITY C1 [Hoger, Sally] Tarleton State Univ, Ft Worth, TX 76104 USA. [Lykens, Kristine; Miller, Thaddeus] Univ N Texas, Hlth Sci Ctr, Ft Worth, TX USA. [Beavers, Suzanne; Katz, Dolly] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Hoger, S (reprint author), Tarleton State Univ, Ft Worth, TX 76104 USA. EM hoger@tarleton.edu NR 5 TC 0 Z9 0 U1 0 U2 0 PU INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) PI PARIS PA 68 BOULEVARD SAINT-MICHEL,, 75006 PARIS, FRANCE SN 1027-3719 EI 1815-7920 J9 INT J TUBERC LUNG D JI Int. J. Tuberc. Lung Dis. PD MAR PY 2015 VL 19 IS 3 BP 367 EP 368 DI 10.5588/ijtld.14.0852-2 PG 2 WC Infectious Diseases; Respiratory System SC Infectious Diseases; Respiratory System GA CC9SO UT WOS:000350711700026 PM 25692934 ER PT J AU Bakian, AV Bilder, DA Carbone, PS Hunt, TD Petersen, B Rice, CE AF Bakian, Amanda V. Bilder, Deborah A. Carbone, Paul S. Hunt, Tyler D. Petersen, Brent Rice, Catherine E. TI Brief Report: Independent Validation of Autism Spectrum Disorder Case Status in the Utah Autism and Developmental Disabilities Monitoring (ADDM) Network Site SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS LA English DT Article DE Autism spectrum disorder; Autism and Developmental Disabilities Monitoring Network; ASD surveillance; ASD prevalence; Validation; DSM-IV-TR ID DIAGNOSTIC SUBSTITUTION; PREVALENCE; SURVEILLANCE; HEALTH AB An independent validation was conducted of the Utah Autism and Developmental Disabilities Monitoring Network's (UT-ADDM) classification of children with autism spectrum disorder (ASD). UT-ADDM final case status (n = 90) was compared with final case status as determined by independent external expert reviewers (EERs). Inter-rater reliability (ICC = 0.84), specificity [0.83 (95 % CI 0.74-0.90)], and sensitivity [0.99 (95 % CI 0.96-1.00)] were high for ASD case versus non-case classification between UT-ADDM and EER. At least one EER disagreed with UT-ADDM on ASD final case status on nine out of 30 records; however, all three EERs disagreed with UT-ADDM for only one record. Findings based on limited data suggest that children with ASD as identified by UT-ADDM are consistently classified as ASD cases by independent autism experts. C1 [Bakian, Amanda V.; Bilder, Deborah A.; Hunt, Tyler D.] Univ Utah, Dept Psychiat, Salt Lake City, UT 84108 USA. [Carbone, Paul S.; Hunt, Tyler D.] Univ Utah, Dept Pediat, Salt Lake City, UT 84108 USA. [Petersen, Brent] Valley Mental Heth Carmen B Pingree Ctr Children, Salt Lake City, UT USA. [Rice, Catherine E.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. RP Bakian, AV (reprint author), Univ Utah, Dept Psychiat, 650 Komas Dr Suite 206, Salt Lake City, UT 84108 USA. EM amanda.bakian@hsc.utah.edu RI Rice, Catherine/D-6305-2016 FU Centers for Disease Control and Prevention [UR3DD000685] FX Surveillance data used for this study were collected under the Grant/Cooperative Agreement UR3DD000685 from the Centers for Disease Control and Prevention. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 21 TC 6 Z9 6 U1 2 U2 4 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0162-3257 EI 1573-3432 J9 J AUTISM DEV DISORD JI J. Autism Dev. Disord. PD MAR PY 2015 VL 45 IS 3 BP 873 EP 880 DI 10.1007/s10803-014-2187-6 PG 8 WC Psychology, Developmental SC Psychology GA CC4FK UT WOS:000350306600022 PM 25022251 ER PT J AU Li, CY Li, CH Forsythe, L Lerro, C Soni, A AF Li, Chunyu Li, Chenghui Forsythe, Laura Lerro, Catherine Soni, Anita TI Mental health services utilization and expenditures associated with cancer survivorship in the United States SO JOURNAL OF CANCER SURVIVORSHIP LA English DT Article DE Cancer; Mental health; Utilization; Expenditures; Prescription drug ID PSYCHOLOGICAL DISTRESS; PSYCHOSOCIAL INTERVENTIONS; POPULATION; CARE; DEPRESSION; TRENDS; EMPLOYMENT; ADJUSTMENT; MORTALITY; PATTERNS AB The aim of this study is to assess mental health services utilization and expenditures associated with cancer history using a nationally representative sample in the US. We used data from the 2008-2011 Medical Expenditure Panel Survey and multivariate regression models to assess mental health services use and expenditures among cancer survivors compared to individuals without a cancer history, stratified by age (18-64 and a parts per thousand yen65 years) and time since diagnosis (a parts per thousand currency sign1 vs. > 1 year). Among adults aged 18-64, compared with individuals without a cancer history, cancer survivors were more likely to screen positive for current psychological distress and depression regardless of time since diagnosis; survivors diagnosed > 1 year ago were more likely to use mental health prescription drugs; those diagnosed within 1 year reported significantly lower annual per capita mental health drug expenditure and out-of-pocket mental health expenditure, while those diagnosed > 1 year presented significantly higher annual per capita mental health expenditure. No significant differences in mental health expenditures were found among adults aged 65 or older. Mental health problems presented higher health and economic burden among younger and longer-term survivors than individuals without a cancer history. This study provides data for monitoring the impact of initiatives to enhance coverage and access for mental health services at the national level. Early detection and appropriate treatment of mental health problems may help improve quality of cancer survivorship. C1 [Li, Chunyu] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA 30341 USA. [Li, Chenghui] Univ Arkansas Med Sci, Coll Pharm, Div Pharmaceut Evaluat & Policy, Little Rock, AR 72205 USA. [Forsythe, Laura] PCORI, Res Integrat & Evaluat Program, Washington, DC USA. [Lerro, Catherine] Amer Canc Soc, Hlth Serv Res Program, Intramural Res Dept, Natl Home Off, Atlanta, GA 30329 USA. [Soni, Anita] Agcy Healthcare Res & Qual, Ctr Financing Access & Cost Trends, Rockville, MD USA. RP Li, CY (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, 4770 Buford Highway NE,MS F-76, Atlanta, GA 30341 USA. EM cli11@cdc.gov FU Intramural CDC HHS [CC999999] NR 39 TC 2 Z9 2 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1932-2259 EI 1932-2267 J9 J CANCER SURVIV JI J. Cancer Surviv.-Res. Pract. PD MAR PY 2015 VL 9 IS 1 BP 50 EP 58 DI 10.1007/s11764-014-0392-0 PG 9 WC Oncology; Social Sciences, Biomedical SC Oncology; Biomedical Social Sciences GA CC4ZB UT WOS:000350364400006 PM 25108481 ER PT J AU Cates, SC Kosa, KM Brophy, JE Hall, AJ Fraser, A AF Cates, Sheryl C. Kosa, Katherine M. Brophy, Jenna E. Hall, Aron J. Fraser, Angela TI Consumer Education Needed on Norovirus Prevention and Control: Findings from a Nationally Representative Survey of US Adults SO JOURNAL OF FOOD PROTECTION LA English DT Article ID HEALTH BELIEF MODEL; UNITED-STATES; FOOD SAFETY; OUTBREAKS; ILLNESS; DISEASE; GASTROENTERITIS; SURVEILLANCE; BEHAVIORS AB Noroviruses (NoVs) are the leading cause of foodborne disease in the United States; however, little is known about consumers' knowledge of NoV infection and their understanding of how to prevent and control associated illness. A nationally representative Web-enabled panel survey of U.S. adults (n = 1,051) was conducted to collect information on consumers' awareness and knowledge of NoVs. Respondents who had heard of NoVs were asked 22 true-and-false questions on the transmission, prevention, and control of NoVs. Forty-seven percent of respondents reported awareness of NoVs, and 85% of respondents had heard of the terms "cruise ship virus," "the stomach bug," or "the stomach flu," which are commonly used to describe NoVs. Of those respondents who had previously heard of NoV or other terms used by consumers to describe NoV (n = 948), 36% correctly answered 11 or more of the 22 true-and-false questions, suggesting that consumers have limited knowledge on how to prevent and control NoV infection. Most consumers do not understand that the primary mode of transmission for NoV infection is fecal to oral, and many have the misperception that meat and poultry are sources of NoV infection. There is the need to educate consumers about how to prevent and control NoV infection. Although there is a proliferation of food safety education materials available, most focus on foodborne bacteria rather than viruses. The survey results will be used to revise existing consumer food safety educational materials to include information on NoV prevention and control. C1 [Cates, Sheryl C.; Kosa, Katherine M.; Brophy, Jenna E.] RTI Int, Res Triangle Pk, NC 27709 USA. [Hall, Aron J.] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30329 USA. [Fraser, Angela] Clemson Univ, Dept Food Nutr & Packaging Sci, Clemson, SC 29634 USA. RP Cates, SC (reprint author), RTI Int, 3040 East Cornwallis Rd,POB 12194, Res Triangle Pk, NC 27709 USA. EM scc@rti.org FU Agriculture and Food Research Initiative Competitive from the USDA, National Institute of Food and Agriculture [2011-68003-30395] FX This research was funded in part through a grant from the Agriculture and Food Research Initiative Competitive grant no. 2011-68003-30395 from the USDA, National Institute of Food and Agriculture. NR 26 TC 3 Z9 3 U1 4 U2 18 PU INT ASSOC FOOD PROTECTION PI DES MOINES PA 6200 AURORA AVE SUITE 200W, DES MOINES, IA 50322-2863 USA SN 0362-028X EI 1944-9097 J9 J FOOD PROTECT JI J. Food Prot. PD MAR PY 2015 VL 78 IS 3 BP 484 EP 490 DI 10.4315/0362-028X.JFP-14-313 PG 7 WC Biotechnology & Applied Microbiology; Food Science & Technology SC Biotechnology & Applied Microbiology; Food Science & Technology GA CC7EU UT WOS:000350531300001 PM 25719870 ER PT J AU Patel, SM Cobb, P Saydah, S Zhang, XP de Jesus, JM Cogswell, ME AF Patel, Sheena M. Cobb, Paul Saydah, Sharon Zhang, Xuanping de Jesus, Janet M. Cogswell, Mary E. TI Dietary Sodium Reduction Does Not Affect Circulating Glucose Concentrations in Fasting Children or Adults: Findings from a Systematic Review and Meta-Analysis SO JOURNAL OF NUTRITION LA English DT Article DE fasting glucose; insulin resistance; meta-analysis; sodium reduction; systematic review ID INSULIN SENSITIVITY; BLOOD-PRESSURE; SALT RESTRICTION; HYPERTENSIVE PATIENTS; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS; NACL RESTRICTION; PLASMA-GLUCOSE; SERUM-LIPIDS AB Background: Although evidence shows that reduced sodium intake lowers blood pressure, some studies suggest that sodium reduction may adversely affect insulin resistance and glucose tolerance. Objectives: The objectives were to assess the effects of sodium reduction on glucose tolerance, evaluate strengths and weaknesses of the relevant scientific literature, and provide direction for future research. Methods: We searched The Cochrane Library, MEDLINE, EMBASE, CINAHL, and Web of Science through August 2014. Both randomized and nonrandomized intervention trialswere included in ourmeta-analyses. The effects of sodium reduction on glucose tolerance were evaluated in 37 articles, but because of a lack of comparable data, 8 trials were excluded from the meta-analyses. Results: Participants were 10-79 y old, either primarily healthy or with hypertension. In meta-analyses of 20 randomized, crossover trials (n = 504 participants) and 9 nonrandomized crossover trials (n = 337), circulating glucose concentrations of fasting participants were not affected by reduction in sodium intake. In contrast, in meta-analyses of 19 of the 20 randomized, crossover trials (n = 494), fasting insulin concentrations were 9.53 pmol/L higher (95% CI: 5.04, 14.02 pmol/L higher) with sodium reduction. In 9 nonrandomized trials (n = 337), fasting insulin did not differ with reduced sodium intake. Results differed little when the analyses were restricted to studies with a low risk of bias and duration of >= 7 d. Conclusions: This meta-analysis revealed no evidence that, in trials with a short intervention and large reductions in sodium, circulating glucose concentrations differed between groups. Recommendations for future studies include extending intervention durations, ensuring comparability of groups at baseline through randomization, and assessing sodium intakes relevant to population sodium reduction. In addition, analyses on other metabolic variables were limited because of the number of trials reporting these outcomes and lack of consistency across measures, suggesting a need for comparable measures of glucose tolerance across studies. C1 [Patel, Sheena M.; Cobb, Paul; Cogswell, Mary E.] CDC, Div Heart Dis & Stroke Prevent, Atlanta, GA 30333 USA. [Saydah, Sharon; Zhang, Xuanping] CDC, Div Diabet Translat, Atlanta, GA 30333 USA. [Patel, Sheena M.] Oak Ridge Inst Sci & Educ, Atlanta, GA USA. [de Jesus, Janet M.] NHLBI, NIH, Bethesda, MD 20892 USA. RP Patel, SM (reprint author), CDC, Div Heart Dis & Stroke Prevent, Atlanta, GA 30333 USA. EM lsp7@cdc.gov FU Department of Energy; CDC FX Supported by appointment to the Research Participation Program (to SMP) for the CDC administered by the Oak Ridge Institute for Science and Education through an agreement between the Department of Energy and CDC. NR 59 TC 3 Z9 3 U1 5 U2 9 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-3166 EI 1541-6100 J9 J NUTR JI J. Nutr. PD MAR PY 2015 VL 145 IS 3 BP 505 EP 513 DI 10.3945/jn.114.195982 PG 9 WC Nutrition & Dietetics SC Nutrition & Dietetics GA CC5RM UT WOS:000350420400019 PM 25733466 ER PT J AU Pfeiffer, CM Sternberg, MR Fazili, Z Yetley, EA Lacher, DA Bailey, RL Johnson, CL AF Pfeiffer, Christine M. Sternberg, Maya R. Fazili, Zia Yetley, Elizabeth A. Lacher, David A. Bailey, Regan L. Johnson, Clifford L. TI Unmetabolized Folic Acid Is Detected in Nearly All Serum Samples from US Children, Adolescents, and Adults SO JOURNAL OF NUTRITION LA English DT Article DE NHANES; serum folate; 5-methyltetrahydrofolate; unmetabolized folic acid; HPLC-tandem mass spectrometry ID TANDEM MASS-SPECTROMETRY; PRIMARY FOLATE FORMS; DIHYDROFOLATE-REDUCTASE; POSTMENOPAUSAL WOMEN; MICROBIOLOGIC ASSAY; UNITED-STATES; CORD BLOOD; NHANES; FORTIFICATION; PLASMA AB Background: Serum total folate consists mainly of 5-methyltetrahydrofolate (5-methylTHF). Unmetabolized folic acid (UMFA) may occur in persons consuming folic acid-fortified foods or supplements. Objectives: We describe serum 5-methylTHF and UMFA concentrations in the US population >= 1 y of age by demographic variables and fasting time, stratified by folic acid-containing dietary supplement use. We also evaluate factors associated with UMFA concentrations >1 nmol/L. Methods: Serum samples from the cross-sectional NHANES 2007-2008 were measured for 5-methylTHF (n = 2734) and UMFA (n = 2707) by HPLC-tandem mass spectrometry. Results: In supplement users compared with nonusers, we found significantly higher geometric mean concentrations of 5-methylTHF (48.4 and 30.7 nmol/L, respectively) and UMFA (1.54 and 0.794 nmol/L, respectively). UMFA concentrations were detectable (>0.3 nmol/L) in >95% of supplement users and nonusers, regardless of demographic or fasting characteristics; concentrations differed significantly by age and fasting time, but not by sex and race-ethnicity, both in supplement users and nonusers. The prevalence of UMFA concentrations >1 nmol/L was 33.2% overall and 21.0% in fasting (>= 8 h) adults (>= 20 y of age). Using multiple logistic regression analysis, UMFA concentrations >1 nmol/L were associated with being older, non-Hispanic black, nonfasting (<8 h), having smaller body surface area, higher total folic acid intake (diet and supplements), and higher red blood cell folate concentrations. In fasting adults, a decrease in the mean daily alcohol consumption was also associated with increased odds of UMFA concentrations >1 nmol/L. Conclusions: UMFA detection was nearly ubiquitous, and concentrations >1 nmol/L were largely but not entirely explained by fasting status and by total folic acid intake from diet and supplements. These new UMFA data in US persons >= 1 y of age provide much-needed information on this vitamer in a fortified population with relatively high use of dietary supplements. C1 [Pfeiffer, Christine M.; Sternberg, Maya R.; Fazili, Zia] CDC, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA. [Yetley, Elizabeth A.; Bailey, Regan L.] NIH, Off Dietary Supplements, Bethesda, MD 20892 USA. [Lacher, David A.; Johnson, Clifford L.] CDC, Natl Ctr Hlth Stat, Hyattsville, MD USA. RP Pfeiffer, CM (reprint author), CDC, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA. EM CPfeiffer@cdc.gov NR 40 TC 15 Z9 15 U1 1 U2 7 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-3166 EI 1541-6100 J9 J NUTR JI J. Nutr. PD MAR PY 2015 VL 145 IS 3 BP 520 EP 531 DI 10.3945/jn.114.201210 PG 12 WC Nutrition & Dietetics SC Nutrition & Dietetics GA CC5RM UT WOS:000350420400021 PM 25733468 ER PT J AU Bailey, RL Fakhouri, TH Park, Y Dwyer, JT Thomas, PR Gahche, JJ Miller, PE Dodd, KW Sempos, CT Murray, DM AF Bailey, Regan L. Fakhouri, Tala H. Park, Yikyung Dwyer, Johanna T. Thomas, Paul R. Gahche, Jaime J. Miller, Paige E. Dodd, Kevin W. Sempos, Christopher T. Murray, David M. TI Multivitamin-Mineral Use Is Associated with Reduced Risk of Cardiovascular Disease Mortality among Women in the United States SO JOURNAL OF NUTRITION LA English DT Article DE cardiovascular disease; dietary supplement; NHANES; mortality; multivitamin-mineral ID ANTIOXIDANT VITAMINS; DIETARY MAGNESIUM; CONTROLLED-TRIAL; HEALTH; CANCER; METAANALYSIS; PREVENTION; ADULTS; SUPPLEMENTS; PATTERNS AB Background: Multivitamin-mineral (MVM) products are the most commonly used supplements in the United States, followed by multivitamin (MV) products. Two randomized clinical trials (RCTs) did not show an effect of MVMs or MVs on cardiovascular disease (CVD) mortality; however, no clinical trial data are available for women with MVM supplement use and CVD mortality. Objective: The objective of this research was to examine the association between MVM and MV use and CVD-specific mortality among US adults without CVD. Methods: A nationally representative sample of adults from the restricted data NHANES III (1988-1994; n = 8678; age >= 40 y) were matched with mortality data reported by the National Death Index through 2011 to examine associations between MVM and MV use and CVD mortality by using Cox proportional hazards models, adjusting for multiple potential confounders. Results: We observed no significant association between CVD mortality and users of MVMs or MVs compared with nonusers; however, when users were classified by the reported length of time products were used, a significant association was found with MVM use of >3 y compared with nonusers (HR: 0.65; 95% CI: 0.49, 0.85). This finding was largely driven by the significant association among women (HR: 0.56; 95% CI: 0.37, 0.85) but not men (HR: 0.79; 95% CI: 0.44, 1.42). No significant association was observed for MV products and CVD mortality in fully adjusted models. Conclusions: In this nationally representative data set with detailed information on supplement use and CVD mortality data similar to 20 y later, we found an association between MVM use of >3 y and reduced CVD mortality risk for women when models controlled for age, race, education, body mass index, alcohol, aspirin use, serum lipids, blood pressure, and blood glucose/glycated hemoglobin. Our results are consistent with the 1 available RCT in men, indicating no relation with MVM use and CVD mortality. C1 [Bailey, Regan L.; Dwyer, Johanna T.; Thomas, Paul R.; Sempos, Christopher T.] NCI, Off Dietary Supplements, NIH, Bethesda, MD 20892 USA. [Murray, David M.] NCI, Off Dis Prevent, NIH, Bethesda, MD 20892 USA. [Park, Yikyung; Miller, Paige E.; Dodd, Kevin W.] NCI, Nihon Univ, Bethesda, MD 20892 USA. [Fakhouri, Tala H.; Gahche, Jaime J.] CDC, Natl Ctr Hlth Stat, Hyattsville, MD USA. RP Bailey, RL (reprint author), NCI, Off Dietary Supplements, NIH, Bethesda, MD 20892 USA. EM baileyr@mail.nih.gov OI Dwyer, Johanna/0000-0002-0783-1769; Park, Yikyung/0000-0002-6281-489X FU NIH, Office of Dietary Supplements FX Supported by NIH, Office of Dietary Supplements. NR 30 TC 4 Z9 4 U1 0 U2 8 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-3166 EI 1541-6100 J9 J NUTR JI J. Nutr. PD MAR PY 2015 VL 145 IS 3 BP 572 EP 578 DI 10.3945/jn.114.204743 PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA CC5RM UT WOS:000350420400027 PM 25733474 ER PT J AU Gajewski, K Burris, D Spears, DR Sullivan, K Oyinloye, O McNeil, C Meechan, P Warnock, E Trapp, J Decker, KC Chapman, S AF Gajewski, Kim Burris, Dara Spears, D. Ross Sullivan, Kevin Oyinloye, Oluremi McNeil, Carrie Meechan, Paul Warnock, Eli Trapp, Jonathan Decker, K. C. Chapman, Sandy TI Demographic Trends of Sick Leave Absenteeism Among Civil Service Employees at a Federal Agency From 2004 to 2012 SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID WORK; PRESENTEEISM; ORGANIZATION; COMMITMENT; HEALTH AB Objective: To investigate the associations between demographic variables and sick leave use. Methods: We analyzed sick leave use among civil servants at a federal agency (FA) from 2004 to 2012 by demographic and FA-specific variables. We used a mixed methods approach and type III analysis to build a descriptive model of sick leave proportions and demographic variables. Results: Sick absenteeism usage varied significantly (variation of greater than one sick day per year) by sex, Emergency Operations Center response tier, length of service at the FA, age, and general schedule pay grade level. Our final descriptive model contained age, sex, response tier and an interaction term between age and sex. Conclusions: Future studies should examine these associations on smaller time scales, perhaps breaking the data down by month or day of the week. C1 [Gajewski, Kim; Burris, Dara; Spears, D. Ross; McNeil, Carrie; Meechan, Paul; Warnock, Eli] Ctr Dis Control & Prevent, Environm Safety & Hlth Compliance Off, Atlanta, GA 30333 USA. [Trapp, Jonathan] Ctr Dis Control & Prevent, Secur Serv Off, Atlanta, GA 30333 USA. [Chapman, Sandy] Ctr Dis Control & Prevent, Program Grants Off, Atlanta, GA 30333 USA. [Sullivan, Kevin] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Oyinloye, Oluremi; Decker, K. C.] Booz Allen Hamilton, Mclean, VA USA. RP Spears, DR (reprint author), Ctr Dis Control & Prevent, CAPT, US Publ Hlth Serv, 1600 Clifton Rd NE,MS F-05, Atlanta, GA 30333 USA. EM ava3@cdc.gov FU Centers for Disease Control and Prevention (CDC), Atlanta, GA FX This study did not receive funding from the National Institutes of Health (NIH), the Wellcome Trust, or the Howard Hughes Medical Institute (HHMI). Source of funding is the Centers for Disease Control and Prevention (CDC), Atlanta, GA. NR 17 TC 0 Z9 0 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1076-2752 EI 1536-5948 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD MAR PY 2015 VL 57 IS 3 BP 277 EP 283 DI 10.1097/JOM.0000000000000347 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CD0XM UT WOS:000350797500013 PM 25742534 ER PT J AU Donauer, S Chen, AM Xu, YY Calafat, AM Sjodin, A Yolton, K AF Donauer, Stephanie Chen, Aimin Xu, Yingying Calafat, Antonia M. Sjodin, Andreas Yolton, Kimberly TI Prenatal Exposure to Polybrominated Diphenyl Ethers and Polyfluoroalkyl Chemicals and Infant Neurobehavior SO JOURNAL OF PEDIATRICS LA English DT Article ID PERFLUORINATED CHEMICALS; SERUM CONCENTRATIONS; FLAME RETARDANTS; U.S. CHILDREN; CORD BLOOD; SCALE; SUBSTANCES; AGE; METHYLAZOXYMETHANOL; PERFLUOROOCTANOATE AB Objective To assess the impact of prenatal exposure to polybrominated diphenyl ethers (PBDEs) and polyfluoroalkyl chemicals (PFCs) on early infant neurobehavior. Study design In a cohort of 349 mother/infant pairs, we measured maternal serum concentrations during pregnancy of PBDEs, including BDE-47 and other related congeners, as well as 2 common PFCs, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid. When the infants were 5 weeks of age, we measured their neurobehavior by using the Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS). Results Neither PBDE nor PFC exposures during gestation were associated with the 11 individual NNNS outcomes included in our study; however, when we used latent profile analysis to categorize infants into neurobehavioral profiles based on performance on the NNNS (social/easygoing, high arousal/difficult, or hypotonic), a 10-fold increase in prenatal PFOA concentrations significantly increased the odds of being categorized as hypotonic compared with social/easygoing (aOR 3.79; 95% CI 1.1-12.8). Conclusions Infants of mothers with greater serum concentrations of PFOA during pregnancy were more likely to be categorized as hypotonic. No association between PBDE concentrations and hypotonia was found. Additional studies should further investigate possible associations of prenatal PFC exposure and muscle tone in infants and children. C1 [Donauer, Stephanie; Xu, Yingying; Yolton, Kimberly] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA. [Chen, Aimin] Univ Cincinnati, Dept Environm Hlth, Cincinnati, OH USA. [Calafat, Antonia M.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. [Sjodin, Andreas] Ctr Dis Control & Prevent, Div Sci Lab, Atlanta, GA USA. RP Donauer, S (reprint author), Cincinnati Childrens Hosp Med Ctr, Dept Pediat, 3333 Burnet Ave, Cincinnati, OH 45229 USA. EM stephanie.donauer@cchmc.org FU National Institute of Environmental Health Sciences [R01 ES015517, T32 HP10027] FX Supported by the National Institute of Environmental Health Sciences (R01 ES015517, T32 HP10027). The authors declare no conflicts of interest. NR 48 TC 4 Z9 4 U1 1 U2 19 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD MAR PY 2015 VL 166 IS 3 BP 736 EP 742 DI 10.1016/j.jpeds.2014.11.021 PG 7 WC Pediatrics SC Pediatrics GA CC2ZL UT WOS:000350213600046 PM 25524317 ER PT J AU Rohan, EA Townsend, JS Fairley, TL Stewart, SL AF Rohan, Elizabeth A. Townsend, Julie S. Fairley, Temeika L. Stewart, Sherri L. TI Health Behaviors and Quality of Life Among Colorectal Cancer Survivors SO JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK LA English DT Article ID BODY-MASS INDEX; COLON-CANCER; RISK-FACTORS; IMPACT; PREVALENCE; OUTCOMES; CARE AB Purpose: To examine, at the population level, health behaviors, comorbidities, and health-related quality of life among colorectal cancer (CRC) survivors compared with other cancer survivors and persons without cancer. Methods: We used data from the 2009 and 2010 Behavioral Risk Factor Surveillance System cancer survivor modules. We calculated descriptive statistics, conducted chi-square tests for comparisons, and used multivariable logistic regression analysis to compare CRC survivors with other cancer survivors and persons without cancer. Results: Of the 52,788 cancer survivors included in this analysis, 4001 reported being CRC survivors. When compared with other cancer survivors, CRC survivors reported higher percentages of obesity and lack of physical activity; however, they had lower levels of current smoking. Adjusted results show that CRC survivors were significantly more likely to report lack of physical activity, fair/poor health, and other chronic health conditions compared with persons without a cancer diagnosis. Conversely, CRC survivors reported lower levels of current smoking than persons without cancer. Conclusions: CRC survivors have a higher proportion of heath conditions and behaviors that may significantly increase their risks for recurrence or development of a second cancer. Targeted interventions to address these health issues should be considered. C1 [Rohan, Elizabeth A.; Townsend, Julie S.; Fairley, Temeika L.; Stewart, Sherri L.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Chamblee, GA 30341 USA. RP Rohan, EA (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, Comprehens Canc Control Branch, 4770 Buford Highway NE,Chamblee Bldg 107,MS F76, Chamblee, GA 30341 USA. EM erohan@cdc.gov FU Intramural CDC HHS [CC999999] NR 26 TC 3 Z9 3 U1 3 U2 8 PU HARBORSIDE PRESS PI COLD SPRING HARBOR PA 37 MAIN ST, COLD SPRING HARBOR, NY 11724 USA SN 1540-1405 EI 1540-1413 J9 J NATL COMPR CANC NE JI J. Natl. Compr. Cancer Netw. PD MAR PY 2015 VL 13 IS 3 BP 297 EP 302 PG 6 WC Oncology SC Oncology GA CD0RN UT WOS:000350781700007 PM 25736006 ER PT J AU Rosenbaum, S AF Rosenbaum, Sara TI Will Health Centers Go Over the "Funding Cliff "? SO MILBANK QUARTERLY LA English DT Article C1 [Rosenbaum, Sara] George Washington Univ, Sch Publ Hlth & Hlth Serv, Hlth Law & Policy, Washington, DC 20006 USA. [Rosenbaum, Sara] George Washington Univ, Sch Publ Hlth & Hlth Serv, Dept Hlth Policy, Washington, DC 20006 USA. [Rosenbaum, Sara] CDC, Directors Advisory Comm, Atlanta, GA 30333 USA. RP Rosenbaum, S (reprint author), George Washington Univ, Sch Publ Hlth & Hlth Serv, 2021 K St NW, Washington, DC 20006 USA. EM sarar@gwu.edu NR 5 TC 1 Z9 1 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0887-378X EI 1468-0009 J9 MILBANK Q JI Milbank Q. PD MAR PY 2015 VL 93 IS 1 BP 32 EP 35 DI 10.1111/1468-0009.12103 PG 4 WC Health Care Sciences & Services; Health Policy & Services SC Health Care Sciences & Services GA CD0HZ UT WOS:000350752800008 PM 25752348 ER PT J AU Salzer, JS Carroll, DS Williams-Newkirk, AJ Lang, S Peterhans, JK Rwego, IB Ockers, S Gillespie, TR AF Salzer, Johanna S. Carroll, Darin S. Williams-Newkirk, Amanda Jo Lang, Stefanie Peterhans, Julian Kerbis Rwego, Innocent B. Ockers, Sandra Gillespie, Thomas R. TI Effects of anthropogenic and demographic factors on patterns of parasitism in African small mammal communities SO PARASITOLOGY LA English DT Article DE ectoparasites; fleas; Giardia; Kibale National Park; lice; mites; Praomys; rodent; ticks; trypanosome ID KIBALE NATIONAL-PARK; WESTERN UGANDA; PATHOGEN TRANSMISSION; INFECTIOUS-DISEASES; GENERAL LAWS; LONG-TERM; BIODIVERSITY; FOREST; PRIMATES; ECOLOGY AB Habitat disturbance often results in alterations in community structure of small mammals. Additionally, the parasites harboured by these small mammals may be impacted by environmental changes or indirectly affected by changes in available hosts. To improve our understanding of this interplay, we examined the patterns of parasitism in small mammal communities from a variety of habitats in forested Uganda. Small mammals were collected from areas experiencing variable habitat disturbance, host density and species richness. The analysis focused on 3 most abundant rodent species, Lophuromys aquilus, Praomys jacksoni and Hylomyscus stella, and a diverse group of parasites they harbour. The impact of various habitat and host community factors on parasite prevalence was examined using linear regression and Spearman's rank-order correlation. We further investigated the parasite communities associated with each individual using correspondence analysis. We determined that, parasite prevalence and richness may be occasionally influenced by community and habitat factors, but taxonomy is a driving force in influencing the parasite community harboured by an individual host. Ultimately, applying general principles across a broad range of disturbance levels and diverse host communities needs to be approached with caution in complex communities. C1 [Salzer, Johanna S.; Williams-Newkirk, Amanda Jo; Gillespie, Thomas R.] Emory Univ, Program Populat Biol Ecol & Evolut, Atlanta, GA 30322 USA. [Salzer, Johanna S.; Carroll, Darin S.; Williams-Newkirk, Amanda Jo; Lang, Stefanie; Rwego, Innocent B.; Gillespie, Thomas R.] Emory Univ, Dept Environm Sci, Atlanta, GA 30322 USA. [Salzer, Johanna S.; Carroll, Darin S.] Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA 30333 USA. [Williams-Newkirk, Amanda Jo] Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Div Vector Borne Dis, Atlanta, GA 30333 USA. [Peterhans, Julian Kerbis] Roosevelt Univ, Coll Profess Studies, Chicago, IL 60605 USA. [Peterhans, Julian Kerbis] Field Museum Nat Hist, Chicago, IL 60605 USA. [Rwego, Innocent B.; Ockers, Sandra; Gillespie, Thomas R.] Emory Univ, Rollins Sch Publ Hlth, Dept Environm Hlth, Atlanta, GA 30322 USA. [Rwego, Innocent B.] Makerere Univ, Dept Biol Sci, Kampala, Uganda. RP Gillespie, TR (reprint author), Emory Univ, Program Populat Biol Ecol & Evolut, 1462 Clifton Rd, Atlanta, GA 30322 USA. EM Gillespie@emory.edu RI Rwego, Innocent/I-5049-2013; OI Rwego, Innocent/0000-0003-1274-7788; Williams-Newkirk, Amanda/0000-0002-3466-2921 FU Emory Global Health Institute; Emory University Environmental Sciences Department FX This research was supported in part by the Emory Global Health Institute, Emory University Environmental Sciences Department and the appointment of J.S.S. to the Research Participation Programme administered by Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement with CDC. NR 55 TC 1 Z9 1 U1 4 U2 33 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0031-1820 EI 1469-8161 J9 PARASITOLOGY JI Parasitology PD MAR PY 2015 VL 142 IS 3 BP 512 EP 522 DI 10.1017/S0031182014001450 PG 11 WC Parasitology SC Parasitology GA CD1AU UT WOS:000350806800010 PM 25262668 ER PT J AU Peipins, LA McCarty, F Hawkins, NA Rodriguez, JL Scholl, LE Leadbetter, S AF Peipins, Lucy A. McCarty, Frances Hawkins, Nikki A. Rodriguez, Juan L. Scholl, Lawrence E. Leadbetter, Steven TI Cognitive and affective influences on perceived risk of ovarian cancer SO PSYCHO-ONCOLOGY LA English DT Article DE Cancer; Oncology; Risk perception; ovarian cancer; Path analysis ID BREAST-CANCER; FAMILY-HISTORY; PERCEPTION; WOMEN; IMPACT; PREDICTORS; INFORMATION; FEELINGS; THOUGHTS; EMOTION AB IntroductionStudies suggest that both affective and cognitive processes are involved in the perception of vulnerability to cancer and that affect has an early influence in this assessment of risk. We constructed a path model based on a conceptual framework of heuristic reasoning (affect, resemblance, and availability) coupled with cognitive processes involved in developing personal models of cancer causation. MethodsFrom an eligible cohort of 16700 women in a managed care organization, we randomly selected 2524 women at high, elevated, and average risk of ovarian cancer and administered a questionnaire to test our model (response rate 76.3%). Path analysis delineated the relationships between personal and cognitive characteristics (number of relatives with cancer, age, ideas about cancer causation, perceived resemblance to an affected friend or relative, and ovarian cancer knowledge) and emotional constructs (closeness to an affected relative or friend, time spent processing the cancer experience, and cancer worry) on perceived risk of ovarian cancer. ResultsOur final model fit the data well (root mean square error of approximation (RMSEA)=0.028, comparative fit index (CFI)=0.99, normed fit index (NFI)=0.98). This final model (1) demonstrated the nature and direction of relationships between cognitive characteristics and perceived risk; (2) showed that time spent processing the cancer experience was associated with cancer worry; and (3) showed that cancer worry moderately influenced perceived risk. DiscussionOur results highlight the important role that family cancer experience has on cancer worry and shows how cancer experience translates into personal risk perceptions. This understanding informs the discordance between medical or objective risk assessment and personal risk assessment. Published in 2014. This article is a U.S. Government work and is in the public domain in the USA. C1 [Peipins, Lucy A.; Hawkins, Nikki A.; Rodriguez, Juan L.; Leadbetter, Steven] CDC, Epidemiol & Appl Res Branch, Div Canc Prevent & Control, Atlanta, GA 30333 USA. [McCarty, Frances] CDC, Natl Ctr Hlth Stat, Hyattsville, MD USA. [Scholl, Lawrence E.] ICF Int, Fairfax, VA USA. RP Peipins, LA (reprint author), MS K76 4770 Buford Highway NE, Atlanta, GA 30341 USA. EM lpeipins@cdc.gov FU Centers for Disease Control and Prevention [200-2002-00574, 0015] FX We thank Susan Zaro (ICF International) for project oversight. Funding support was provided by the Centers for Disease Control and Prevention (Contract No. 200-2002-00574, Task order 0015). NR 39 TC 1 Z9 1 U1 3 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1057-9249 EI 1099-1611 J9 PSYCHO-ONCOLOGY JI Psycho-Oncol. PD MAR PY 2015 VL 24 IS 3 BP 279 EP 286 DI 10.1002/pon.3593 PG 8 WC Oncology; Psychology; Psychology, Multidisciplinary; Social Sciences, Biomedical SC Oncology; Psychology; Biomedical Social Sciences GA CD2NA UT WOS:000350913900005 PM 24916837 ER PT J AU Deroche, CB Holland, MM McDermott, S Royer, JA Hardin, JW Mann, JR Salzberg, D Ozturk, O Ouyang, LJ AF Deroche, Chelsea B. Holland, Margaret M. McDermott, Suzanne Royer, Julie A. Hardin, James W. Mann, Joshua R. Salzberg, Deborah Ozturk, Orgul Ouyang, Lijing TI Development of a tool to describe overall health, social independence and activity limitation of adolescents and young adults with disability SO RESEARCH IN DEVELOPMENTAL DISABILITIES LA English DT Article DE Survey instrument; Quality of life; Rare conditions; Factor analysis; Fragile X syndrome; Muscular dystrophy; Spina bifida ID FRAGILE-X-SYNDROME; QUALITY-OF-LIFE; ISSUES AB There is a need for research that focuses on the correlation between self-perceived quality of life (QoL) and the health outcomes of adolescents with disability transitioning to adulthood. To better understand the transition experience of adolescents and young adults with disability, we developed a questionnaire to assess the impact of disability on QoL. We recruited 174 participants who were 15-24 years old and diagnosed with Fragile X syndrome (FXS), spina bifida (SB) or muscular dystrophy (MD) and conducted an exploratory factor analysis to identify factors that characterize QoL. Five factors emerged: emotional health, physical health, independence, activity limitation, and community participation. To validate the tool, we linked medical claims and other administrative data records and examined the association of the factor scores with health care utilization and found the questionnaire can be utilized among diverse groups of young people with disability. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Deroche, Chelsea B.; Holland, Margaret M.; McDermott, Suzanne; Hardin, James W.; Salzberg, Deborah] Univ S Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA. [Mann, Joshua R.] Univ S Carolina, Sch Med, Dept Family & Prevent Med, Columbia, SC 29203 USA. [Royer, Julie A.] Revenue & Fiscal Affairs Off, Hlth & Demog, Columbia, SC 29201 USA. [Ozturk, Orgul] Univ S Carolina, Moore Sch Business, Dept Econ, Columbia, SC 29208 USA. [Ouyang, Lijing] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Deroche, CB (reprint author), Univ S Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, 915 Greene St, Columbia, SC 29208 USA. EM derochcb@email.sc.edu; hollanmm@mailbox.sc.edu; SCMCDERM0@mailbox.sc.edu; Julie.Royer@rfa.sc.gov; JHARDIN@mailbox.sc.edu; Joshua.mann@uscmed.sc.edu; salzberd@mailbox.sc.edu; odozturk@moore.sc.edu; eop9@cdc.gov RI Deroche, Chelsea/D-6423-2016; Hardin, James/Q-7617-2016 OI Salzberg, Deborah/0000-0002-1827-3715; Deroche, Chelsea/0000-0002-8860-6095; Hardin, James/0000-0003-0506-5500 FU Centers for Disease Control and Prevention [1U01DD000776-1] FX This work was supported by the Centers for Disease Control and Prevention under the Grant # 1U01DD000776-1. NR 12 TC 0 Z9 1 U1 3 U2 18 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0891-4222 J9 RES DEV DISABIL JI Res. Dev. Disabil. PD MAR PY 2015 VL 38 BP 288 EP 300 DI 10.1016/j.ridd.2014.12.009 PG 13 WC Education, Special; Rehabilitation SC Education & Educational Research; Rehabilitation GA CD0QO UT WOS:000350779200027 PM 25577179 ER PT J AU Mutebi, JP Godsey, M Smith, RP Renell, MR Smith, L Robinson, S Sears, S Lubelczyk, C AF Mutebi, John-Paul Godsey, Marvin Smith, Robert P., Jr. Renell, Melanie R. Smith, Leticia Robinson, Sara Sears, Stephen Lubelczyk, Charles TI Prevalence of Eastern Equine Encephalitis Virus Antibodies Among White-Tailed Deer Populations in Maine SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Eastern equine encephalitis virus; Maine; White-tailed deer; Plaque-reduction neutralization test; Odocoileus virginianus ID MOOSE; VERMONT AB During the fall of 2010, 332 deer serum samples were collected from 15 of the 16 (93.8%) Maine counties and screened for eastern equine encephalitis virus (EEEV) antibodies using plaque reduction neutralizing tests (PRNTs). The aim was to detect and map EEEV activity in the state of Maine. Forty-seven of the 332 (14.2%) sera were positive for EEEV antibodies, showing a much wider distribution of EEEV activity in Maine than previously known. The percentage of EEEV antibody-positive deer sera was >= 10% in six counties-Piscataquis (100%), Somerset (28.6%), Waldo (22.2%), Penobscot (21.7%), Kennebec (13.7%), and Sagadahoc (10%). Positive sera were detected in all the six counties (Somerset, Waldo, Penobscot, Kennebec, Cumberland, and York) that were positive in 2009, suggesting endemic EEEV activity in these counties. EEEV antibodies were not detected in sera collected in five counties-Franklin, Knox, Lincoln, Oxford, and Washington-which was either due to low sample size or lack of EEEV activity in these counties. Our data suggest higher EEEV activity in central Maine compared to southern Maine, whereas EEEV activity in Maine has historically been associated with the southern counties of York and Cumberland. C1 [Mutebi, John-Paul; Godsey, Marvin] Ctr Dis Control & Prevent, DVBD, Ft Collins, CO 80521 USA. [Smith, Robert P., Jr.; Renell, Melanie R.; Lubelczyk, Charles] Maine Med Ctr Res Inst, Vector Borne Dis Lab, Scarborough, ME USA. [Smith, Leticia] Cornell Univ, Dept Entomol, Ithaca, NY 14853 USA. [Robinson, Sara] Maine Dept Hlth & Human Serv, Augusta, ME USA. [Sears, Stephen] VA Maine Healthcare Syst, Augusta, ME USA. RP Mutebi, JP (reprint author), Ctr Dis Control & Prevent, DVBD, 3150 Rampart Rd, Ft Collins, CO 80521 USA. EM jmutebi@cdc.gov FU Centers for Disease Control and Prevention; Maine Medical Research Center FX We thank Susan Elias (Maine Medical Center Research Institute) and Bethany Swope and Kali Saxton-Shaw (CDC) for logistics, laboratory, and field assistance during this study and Becky Eisen and Katherine MacMillan (CDC) for their assistance with spatial analysis and mapping functions. We especially thank Dr. Joseph Staples and the students of the University of Southern Maine, Portland; Dr. David Knupp and the students of Unity College, Unity; Dr. Stephen Hansen and the students of the University of Maine at Fort Kent; Dr. Lee Kantar and the Maine Department of Inland Fisheries and Wildlife; and US Department of Agriculture (USDA) Wildlife Services for their help collecting samples at tagging stations. This study was supported by funds from the Centers for Disease Control and Prevention and the Maine Medical Research Center. NR 13 TC 0 Z9 0 U1 1 U2 5 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 EI 1557-7759 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD MAR 1 PY 2015 VL 15 IS 3 BP 210 EP 214 DI 10.1089/vbz.2014.1696 PG 5 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CD7NE UT WOS:000351276400006 PM 25793477 ER PT J AU Kandukuri, S Morgan, M Zakowski, P Govinda, V Falk, J Roy, S Chaux, G Ghandehari, S Wu, JL AF Kandukuri, Shivani Morgan, Margie Zakowski, Phillip Govinda, Visvesvara Falk, Jeremy Roy, Sharon Chaux, George Ghandehari, Sara Wu, Julie TI Transplant Patient With Skin Nodules SO AMERICAN JOURNAL OF DERMATOPATHOLOGY LA English DT Editorial Material C1 [Kandukuri, Shivani] Cedars Sinai Med Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90048 USA. [Morgan, Margie] Cedars Sinai Med Ctr, Dept Microbiol, Los Angeles, CA 90048 USA. [Zakowski, Phillip; Falk, Jeremy; Chaux, George; Wu, Julie] Cedars Sinai Med Ctr, Dept Internal Med Infect Dis, Los Angeles, CA 90048 USA. [Govinda, Visvesvara; Roy, Sharon] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA USA. [Ghandehari, Sara] Cedars Sinai Hlth Sci, Dept Pulm Crit Care, Los Angeles, CA USA. RP Kandukuri, S (reprint author), Cedars Sinai Med Ctr, Dept Pathol & Lab Med, Pacific Theater Bldg,116 North Robertson Blvd 500, Los Angeles, CA 90048 USA. EM shivani.kandukuri@cshs.org NR 1 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0193-1091 EI 1533-0311 J9 AM J DERMATOPATH JI Am. J. Dermatopathol. PD MAR PY 2015 VL 37 IS 3 BP 229 EP 231 PG 3 WC Dermatology SC Dermatology GA CC4AW UT WOS:000350294000010 PM 25699978 ER PT J AU Kandukuri, S Morgan, M Zakowski, P Govinda, V Falk, J Roy, S Chaux, G Ghandehari, S Wu, JL AF Kandukuri, Shivani Morgan, Margie Zakowski, Phillip Govinda, Visvesvara Falk, Jeremy Roy, Sharon Chaux, George Ghandehari, Sara Wu, Julie TI Transplant Patient With Skin Nodules SO AMERICAN JOURNAL OF DERMATOPATHOLOGY LA English DT Editorial Material ID DISSEMINATED ACANTHAMOEBIASIS; BALAMUTHIA-MANDRILLARIS; LUNG-TRANSPLANT; INFECTION C1 [Kandukuri, Shivani] Cedars Sinai Med Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90048 USA. [Morgan, Margie] Cedars Sinai Med Ctr, Dept Microbiol, Los Angeles, CA 90048 USA. [Zakowski, Phillip; Falk, Jeremy; Chaux, George; Wu, Julie] Cedars Sinai Med Ctr, Dept Internal Med Infect Dis, Los Angeles, CA 90048 USA. [Govinda, Visvesvara; Roy, Sharon] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA USA. [Ghandehari, Sara] Cedars Sinai Hlth Sci, Dept Pulm Crit Care, Los Angeles, CA USA. RP Kandukuri, S (reprint author), Cedars Sinai Med Ctr, Dept Pathol & Lab Med, Pacific Theater Bldg,116 North Robertson Blvd 500, Los Angeles, CA 90048 USA. EM shivani.kandukuri@cshs.org NR 11 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0193-1091 EI 1533-0311 J9 AM J DERMATOPATH JI Am. J. Dermatopathol. PD MAR PY 2015 VL 37 IS 3 BP 254 EP 256 PG 3 WC Dermatology SC Dermatology GA CC4AW UT WOS:000350294000016 PM 25699979 ER PT J AU Charles, LE Burchfiel, CM Sarkisian, K Li, SQ Miller, DB Gu, JK Fekedulegn, D Violanti, JM Andrew, ME AF Charles, Luenda E. Burchfiel, Cecil M. Sarkisian, Khachatur Li, Shengqiao Miller, Diane B. Gu, Ja K. Fekedulegn, Desta Violanti, John M. Andrew, Michael E. TI Leptin, Adiponectin, and Heart Rate Variability Among Police Officers SO AMERICAN JOURNAL OF HUMAN BIOLOGY LA English DT Article ID SYMPATHETIC-NERVOUS-SYSTEM; POWER SPECTRAL-ANALYSIS; CARDIOVASCULAR-DISEASE; PLASMA LEPTIN; RISK-FACTORS; ASSOCIATION; RESISTANCE; OBESITY; STRESS; PREDICTORS AB ObjectivesThe Extended Mechanistic Growth Function (EMGF) method (Clementi et al. [1999]: Am J Med Genet 87:317-323) is a possible alternative to the Cole and Green LMS method ([1992] Stat Med 11:1305-1319) to construct cross-sectional anthropometric charts. It differs from the technique used by Kuczmarski et al. ([2002]: Vital Health Stat 11:1-190) to trace the CDC growth charts in that all centiles are simultaneously fitted with a single function. The aim of this study is to show how an EMGF model can be designed. MethodsTo illustrate the structure and properties of the EMGF method, the data of the Italian Neonatal Study (Bertino et al. [2010]: J Pediatr Gastroenterol Nutr 51:353-361) were analyzed. The dataset included the birth weight of 45,272 single liveborn babies with gestational ages ranging from 23 to 42 weeks. The EMGF method consists of three steps. In the preliminary step, selected age-dependent raw centiles of the anthropometric trait are computed. In the smoothing step, all centiles are simultaneously fitted with a growth function extended with the inclusion of a few extra parameters. In the transformation step, estimates of the age-dependent L (skewness), M (median), and S (coefficient of variation) parameters are derived. ResultsA four-parameter generalized logistic function, extended with five parameters to model between-sex differences, distance between centiles and their slope, was found to fit the raw centiles of birth weight distribution with a residual standard deviation of 51.3 g. ConclusionsThe EMGF method represents a bridge to link cross-sectional and longitudinal studies and allows us to identify milestones of the median growth in a population in the same way used for individual profiles. Am. J. Hum. Biol. 27:175-183, 2015. (c) 2014 Wiley Periodicals, Inc. C1 [Charles, Luenda E.; Burchfiel, Cecil M.; Sarkisian, Khachatur; Gu, Ja K.; Fekedulegn, Desta; Andrew, Michael E.] NIOSH, Biostat & Epidemiol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. [Li, Shengqiao] Univ Pittsburgh, Med Ctr Hlth Plan, Pittsburgh, PA USA. [Miller, Diane B.] NIOSH, Toxicol & Mol Biol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. [Violanti, John M.] SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Epidemiol & Environm Hlth, Buffalo, NY 14260 USA. RP Charles, LE (reprint author), NIOSH, Biostat & Epidemiol Branch, Hlth Effects Lab Div, MS L-4050,1095 Willowdale Rd, Morgantown, WV 26505 USA. EM lcharles@cdc.gov RI milani, silvano/I-7889-2012 OI milani, silvano/0000-0002-5677-1758 FU National Institute for Occupational Safety and Health (NIOSH) [200-2003-01580] FX Contract grant sponsor: National Institute for Occupational Safety and Health (NIOSH); Contract grant number: 200-2003-01580. NR 51 TC 3 Z9 3 U1 0 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1042-0533 EI 1520-6300 J9 AM J HUM BIOL JI Am. J. Hum. Biol. PD MAR-APR PY 2015 VL 27 IS 2 BP 184 EP 191 DI 10.1002/ajhb.22635 PG 8 WC Anthropology; Biology SC Anthropology; Life Sciences & Biomedicine - Other Topics GA CC6KH UT WOS:000350473300005 PM 25270126 ER PT J AU Hoerger, TJ Simpson, SA Yarnoff, BO Pavkov, ME Burrows, NR Saydah, SH Williams, DE Zhuo, XH AF Hoerger, Thomas J. Simpson, Sean A. Yarnoff, Benjamin O. Pavkov, Meda E. Burrows, Nilka Rios Saydah, Sharon H. Williams, Desmond E. Zhuo, Xiaohui TI The Future Burden of CKD in the United States: A Simulation Model for the CDC CKD Initiative SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Article DE Chronic kidney disease (CKD); disease burden; simulation model; lifetime incidence; prevalence; disease trajectory; United States; CKD Health Policy Model; Centers for Disease Control and Prevention CKD Initiative; public health ID CHRONIC KIDNEY-DISEASE; LEFT-VENTRICULAR HYPERTROPHY; CARDIOVASCULAR-DISEASE; COST-EFFECTIVENESS; LIFETIME RISK; US ADULTS; MORTALITY; HEALTH; ASSOCIATION; POPULATION AB Background: Awareness of chronic kidney disease (CKD), defined by kidney damage or reduced glomerular filtration rate, remains low in the United States, and few estimates of its future burden exist. Study Design: We used the CKD Health Policy Model to simulate the residual lifetime incidence of CKD and project the prevalence of CKD in 2020 and 2030. The simulation sample was based on nationally representative data from the 1999 to 2010 National Health and Nutrition Examination Surveys. Setting & Population: Current US population. Model, Perspective, & Timeline: Simulation model following up individuals from current age through death or age 90 years. Outcomes: Residual lifetime incidence represents the projected percentage of persons who will develop new CKD during their lifetimes. Future prevalence is projected for 2020 and 2030. Measurements: Development and progression of CKD are based on annual decrements in estimated glomerular filtration rates that depend on age and risk factors. Results: For US adults aged 30 to 49, 50 to 64, and 65 years or older with no CKD at baseline, the residual lifetime incidences of CKD are 54%, 52%, and 42%, respectively. The prevalence of CKD in adults 30 years or older is projected to increase from 13.2% currently to 14.4% in 2020 and 16.7% in 2030. Limitations: Due to limited data, our simulation model estimates are based on assumptions about annual decrements in estimated glomerular filtration rates. Conclusions: For an individual, lifetime risk of CKD is high, with more than half the US adults aged 30 to 64 years likely to develop CKD. Knowing the lifetime incidence of CKD may raise individuals' awareness and encourage them to take steps to prevent CKD. From a national burden perspective, we estimate that the population prevalence of CKD will increase in coming decades, suggesting that development of interventions to slow CKD onset and progression should be considered. (C) 2015 by the National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved. C1 [Hoerger, Thomas J.; Simpson, Sean A.; Yarnoff, Benjamin O.] RTI Inc, Res Triangle Pk, NC 27709 USA. [Pavkov, Meda E.; Burrows, Nilka Rios; Saydah, Sharon H.; Williams, Desmond E.; Zhuo, Xiaohui] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Hoerger, TJ (reprint author), RTI Inc, 3040 E Cornwallis Rd,POB 12194, Res Triangle Pk, NC 27709 USA. EM tjh@rti.org FU CDC [200-2008- 27958] FX This research was supported by funding (contract 200-2008- 27958) from the CDC. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the CDC. NR 34 TC 39 Z9 41 U1 2 U2 9 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-6386 EI 1523-6838 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD MAR PY 2015 VL 65 IS 3 BP 403 EP 411 DI 10.1053/j.ajkd.2014.09.023 PG 9 WC Urology & Nephrology SC Urology & Nephrology GA CC2JD UT WOS:000350170400011 PM 25468386 ER PT J AU Arguello, DF Tomashek, KM Quinones, L Beltran, M Acosta, L Santiago, LM Biggerstaff, BJ Garcia-Rivera, EJ Sun, W Pollissard-Gadroy, L Luxemburger, C Hunsperger, E AF Argueello, D. Fermin Tomashek, Kay M. Quinones, Luz Beltran, Manuela Acosta, Luz Santiago, Luis M. Biggerstaff, Brad J. Garcia-Rivera, Enid J. Sun, Wellington Pollissard-Gadroy, Laurence Luxemburger, Christine Hunsperger, Elizabeth TI Incidence of Dengue Virus Infection in School-Aged Children in Puerto Rico: A Prospective Seroepidemiologic Study SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID LINKED-IMMUNOSORBENT-ASSAY; RISK-FACTORS; PROSPECTIVE COHORT; HEMORRHAGIC-FEVER; SHOCK SYNDROME; OUTBREAK; THAILAND; SCHOOLCHILDREN; SURVEILLANCE; ANTIBODIES AB Dengue is a potentially fatal acute febrile illness caused by the mosquito-borne dengue viruses (DENV-1 to -4). To estimate DENV seroincidence in school-aged children, a 1-year prospective cohort study was conducted in Patillas, Puerto Rico; 10- to 18-year-olds (N = 345) were randomly selected from 13 public schools. At enrollment, 49.8% of the entire cohort had DENV immunoglobulin G (IgG) anti-DENV antibodies, and there were individuals with neutralizing antibodies specific to each of the four DENV. The mean age of participants with incident DENV infection was 13.4 years. The 1-year seroincidence rate was 5.6%, and 61.1% of infections were inapparent. Having IgG anti-DENV at enrollment was associated with seroincidence (risk ratio = 6.8). Acute febrile illnesses during the study period were captured by a fever diary and an enhanced and passive surveillance system in the municipios of Patillas and Guayama. In summary, at enrollment, nearly one-half of the participants had a prior DENV infection, with the highest incidence in the 10- to 11-year-olds, of which most were inapparent infections, and symptomatic infections were considered mild. C1 [Argueello, D. Fermin; Tomashek, Kay M.; Quinones, Luz; Beltran, Manuela; Acosta, Luz; Santiago, Luis M.; Hunsperger, Elizabeth] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Vector Borne Dis, Dengue Branch, San Juan, PR USA. [Biggerstaff, Brad J.] Ctr Dis Control & Prevent, Off Director, Natl Ctr Emerging & Zoonot Dis, Div Vector Borne Dis, Ft Collins, CO USA. [Garcia-Rivera, Enid J.] Univ Puerto Rico, Sch Med, San Juan, PR 00936 USA. [Sun, Wellington] US FDA, Silver Spring, MD USA. [Pollissard-Gadroy, Laurence] Sanofi Aventis, Paris, France. [Luxemburger, Christine] Sanofi Pasteur, Lyon, France. RP Hunsperger, E (reprint author), CDC Dengue Branch, 1324 Calle Canada, San Juan, PR 00920 USA. EM dfmanito@gmail.com; kay.tomashek@nih.gov; luzquinones@hotmail.com; mvb6@cdc.gov; lda9@cdc.gov; bkb5@cdc.gov; enid.garcia3@upr.edu; Wellington.Sun@fda.hhs.gov; laurencehmp@gmail.com; Christine.Luxemburger@sanofipasteur.com; enh4@cdc.gov FU Cooperative Research and Development Agreement (CRDA) [CID-01-138-02]; Sanofi Pasteur, Inc. FX This work was supported, in part, under Cooperative Research and Development Agreement (CRDA) CID-01-138-02 with Sanofi Pasteur, Inc. NR 34 TC 0 Z9 0 U1 1 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAR PY 2015 VL 92 IS 3 BP 486 EP 491 DI 10.4269/ajtmh.14-0231 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA CC7EB UT WOS:000350529400007 PM 25646256 ER PT J AU Kitau, R Datta, SS Patel, MK Hennessey, K Wannemuehler, K Sui, G Lagani, W AF Kitau, Russel Datta, Siddhartha Sankar Patel, Minal K. Hennessey, Karen Wannemuehler, Kathleen Sui, Gerard Lagani, William TI Hepatitis B Surface Antigen Seroprevalence among Children in Papua New Guinea, 2012-2013 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID VIRUS INFECTION; COLD-CHAIN; CONTROL PROGRAM; PORT-MORESBY; VACCINATION; PREVALENCE; DELIVERY; VIETNAM; EPIDEMIOLOGY; IMMUNIZATION AB Approximately 8% of the population in Papua New Guinea (PNG) has chronic hepatitis B virus (HBV) infection. To decrease the burden of chronic HBV infection, a national 3-dose infant hepatitis B vaccination program was implemented starting in 1989, with a birth dose (BD) added to the schedule in 1992. To assess the impact of the hepatitis B vaccination program, we conducted a serosurvey among children born after vaccine introduction. During 2012-2013, a cross-sectional stratified four-stage cluster survey was conducted to estimate hepatitis B surface antigen (HBsAg) prevalence among children 4-6 years of age. We collected demographic data, vaccination history, and tested children for HBsAg. Of 2,133 participants, 2,130 children had vaccination data by either card or recall: 28% received a BD; 81% received >= 3 vaccine doses. Of 2,109 children providing a blood sample, 60 (2.3%) tested positive for HBsAg. This is the largest, most geographically diverse survey of hepatitis B vaccination and HBsAg seroprevalence done in PNG. Progress has been made in PNG toward the Western Pacific Regional goal to reduce the prevalence of chronic HBV infection to < 1% by 2017 among 5-year-old children. Vaccination efforts should be strengthened, including increasing BD coverage and completing the 3-dose series. C1 Univ Papua New Guinea, Sch Med & Hlth Sci, Publ Hlth Div, Port Moresby, Papua N Guinea. World Hlth Org, Port Moresby, Papua N Guinea. [Patel, Minal K.; Wannemuehler, Kathleen] Ctr Dis Control & Prevent, Global Immunizat Div, Atlanta, GA USA. World Hlth Org, Reg Off Western Pacific, Expanded Programme Immunizat, Manila, Philippines. [Sui, Gerard; Lagani, William] Natl Dept Hlth, Expanded Programme Immunizat, Port Moresby, National Capita, Papua N Guinea. [Datta, Siddhartha Sankar] WHO Representat Off Lao Peoples Democrat Republ, Sisattanak Dist, Vientiane, Laos. [Kitau, Russel] Univ Papua New Guinea, Sch Med & Hlth Sci, Publ Hlth Div, National Capital Dist, Papua N Guinea. [Hennessey, Karen] World Hlth Org, Programme Immunizat, Geneva, Switzerland. RP Datta, SS (reprint author), WHO Representat Off Lao Peoples Democrat Republ, 15 Saphanthong Rd,Unit 5, Sisattanak Dist, Vientiane, Laos. EM rkitau25@gmail.com; dattas@wpro.who.int; hgo9@cdc.gov; hennesseyk@who.int; kpw9@cdc.gov; gerard.sui2011@gmail.com; lagani.william@gmail.com FU WHO; PNG National Department of Health FX Funding for this survey was provided by the WHO and the PNG National Department of Health. NR 38 TC 3 Z9 3 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAR PY 2015 VL 92 IS 3 BP 501 EP 506 DI 10.4269/ajtmh.14-0537 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA CC7EB UT WOS:000350529400010 PM 25582692 ER PT J AU Rosenberg, R AF Rosenberg, Ronald TI Detecting the emergence of novel, zoonotic viruses pathogenic to humans SO CELLULAR AND MOLECULAR LIFE SCIENCES LA English DT Review DE Emerging diseases; Zoonoses; Acute febrile illness; Arboviruses; Surveillance; Big hitter ID INFECTIOUS-DISEASES; FEBRILE ILLNESSES; NON-MALARIA; DISCOVERY; TRANSMISSION; CORONAVIRUS; PHLEBOVIRUS; DIVERSITY; RICHNESS; ETIOLOGY AB RNA viruses, with their high potential for mutation and epidemic spread, are the most common class of pathogens found as new causes of human illness. Despite great advances made in diagnostic technology since the 1950s, the annual rate at which novel virulent viruses have been found has remained at 2-3. Most emerging viruses are zoonoses; they have jumped from mammal or bird hosts to humans. An analysis of virus discovery indicates that the small number of novel viruses discovered annually is an artifact of inadequate surveillance in tropical and subtropical countries, where even established endemic pathogens are often misdiagnosed. Many of the emerging viruses of the future are already infecting humans but remain to be uncovered by a strategy of disease surveillance in selected populations. C1 Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. RP Rosenberg, R (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, Rampart Rd, Ft Collins, CO 80521 USA. EM viruslist@cdc.gov FU Intramural CDC HHS [CC999999] NR 57 TC 12 Z9 12 U1 1 U2 36 PU SPRINGER BASEL AG PI BASEL PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND SN 1420-682X EI 1420-9071 J9 CELL MOL LIFE SCI JI Cell. Mol. Life Sci. PD MAR PY 2015 VL 72 IS 6 BP 1115 EP 1125 DI 10.1007/s00018-014-1785-y PG 11 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA CC4EJ UT WOS:000350303300006 PM 25416679 ER PT J AU Gallivan, M Shah, N Flood, J AF Gallivan, Mark Shah, Neha Flood, Jennifer TI Epidemiology of Human Mycobacterium bovis Disease, California, USA, 2003-2011 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID SAN-DIEGO COUNTY; UNITED-STATES; HUMAN TUBERCULOSIS; BAJA-CALIFORNIA; RISK-FACTORS; TRANSMISSION; INFECTION; CHILDREN; MEXICO; BCG AB We conducted a retrospective review of California tuberculosis (TB) registry and genotyping data to evaluate trends, analyze epidemiologic differences between adult and child case-patients with Mycobacterium bovis disease, and identify risk factors for M. bovis disease. The percentage of TB cases attributable to M. bovis increased from 3.4% (80/2,384) in 2003 to 5.4% (98/1,808) in 2011 (p = 0.002). All (6/6) child case-patients with M. bovis disease during 2010-2011 had >= 1 parent/guardian who was born in Mexico, compared with 38% (22/58) of child case-patients with M. tuberculosis disease (p = 0.005). Multivariate analysis of TB case-patients showed Hispanic ethnicity, extrapulmonary disease, diabetes, and immunosuppressive conditions, excluding HIV co-infection, were independently associated with M. bovis disease. Prevention efforts should focus on Hispanic binational families and adults with immunosuppressive conditions. Collection of additional risk factors in the national TB surveillance system and expansion of whole-genome sequencing should be considered. C1 [Gallivan, Mark; Shah, Neha; Flood, Jennifer] Calif Dept Publ Hlth, Richmond, CA 94804 USA. [Shah, Neha] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Gallivan, M (reprint author), Calif Dept Publ Hlth, Immunizat Branch, 850 Marina Bay Pkwy, Richmond, CA 94804 USA. EM mark.gallivan@cdph.ca.gov FU CDC [1U38HM000414] FX This project was supported in part by the appointment of M.G. to the Applied Epidemiology Fellowship Program administered by the Council of State and Territorial Epidemiologists and by funding from CDC (cooperative agreement no. 1U38HM000414). NR 31 TC 12 Z9 12 U1 3 U2 11 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD MAR PY 2015 VL 21 IS 3 BP 435 EP 443 DI 10.3201/eid2103.141539 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CC3SI UT WOS:000350269300006 PM 25693687 ER PT J AU Rainisch, G Shankar, M Wellman, M Merlin, T Meltzer, MI AF Rainisch, Gabriel Shankar, Manjunath Wellman, Michael Merlin, Toby Meltzer, Martin I. TI Regional Spread of Ebola Virus, West Africa, 2014 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID DISEASE AB To explain the spread of the 2014 Ebola epidemic in West Africa, and thus help with response planning, we analyzed publicly available data. We found that the risk for infection in an area can be predicted by case counts, population data, and distances between affected and nonaffected areas. C1 [Rainisch, Gabriel; Shankar, Manjunath; Wellman, Michael; Merlin, Toby; Meltzer, Martin I.] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. RP Rainisch, G (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop C18, Atlanta, GA 30329 USA. EM grainisch@cdc.gov NR 10 TC 6 Z9 6 U1 2 U2 38 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD MAR PY 2015 VL 21 IS 3 BP 444 EP 447 DI 10.3201/eid2103.141845 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CC3SI UT WOS:000350269300007 PM 25693782 ER PT J AU Haddad, MB Mitruka, K Oeltmann, JE Johns, EB Navin, TR AF Haddad, Maryam B. Mitruka, Kiren Oeltmann, John E. Johns, Emma B. Navin, Thomas R. TI Characteristics of Tuberculosis Cases that Started Outbreaks in the United States, 2002-2011 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID TRANSMISSION AB A review of 26 tuberculosis outbreaks in the United States (2002-2011) showed that initial source case-patients had long infectious periods (median 10 months) and were characterized by substance abuse, incarceration, and homelessness. Improved timeliness of diagnosis and thorough contact investigations for such cases may reduce the risk for outbreaks. C1 [Haddad, Maryam B.; Mitruka, Kiren; Oeltmann, John E.; Johns, Emma B.; Navin, Thomas R.] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. [Haddad, Maryam B.; Johns, Emma B.] Emory Univ, Atlanta, GA 30322 USA. RP Haddad, MB (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop E10, Atlanta, GA 30329 USA. EM mhaddad@cdc.gov FU CDC; External Medical Affairs, Pfizer Inc. FX At the time of this review, E.B.J. was on a 1-year fellowship in applied epidemiology at CDC. The CDC Experience was made possible by a public/private partnership supported by a grant to the CDC Foundation from External Medical Affairs, Pfizer Inc. All other funding and material support for this review were provided by CDC. NR 11 TC 4 Z9 4 U1 0 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD MAR PY 2015 VL 21 IS 3 BP 508 EP 510 DI 10.3201/eid2103.141475 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CC3SI UT WOS:000350269300025 PM 25695665 ER PT J AU Chorba, T AF Chorba, Terence TI A Master Medalist, a President, Tuberculosis, and a Congress: Contributions More Lasting than Bronze SO EMERGING INFECTIOUS DISEASES LA English DT Editorial Material C1 [Chorba, Terence] Ctr Dis Control & Prevent, Field Serv & Evaluat Branch, Div TB Eliminat, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30329 USA. RP Chorba, T (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop E10, Atlanta, GA 30329 USA. EM tlc2@cdc.gov NR 7 TC 0 Z9 0 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD MAR PY 2015 VL 21 IS 3 BP 553 EP 554 DI 10.3201/eid2103.AC2103 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CC3SI UT WOS:000350269300044 ER PT J AU Boscarino, JA Lu, M Moorman, AC Gordon, SC Rupp, LB Spradling, PR Teshale, EH Schmidt, MA Vijayadeva, V Holmberg, SD AF Boscarino, Joseph A. Lu, Mei Moorman, Anne C. Gordon, Stuart C. Rupp, Loralee B. Spradling, Philip R. Teshale, Eyasu H. Schmidt, Mark A. Vijayadeva, Vinutha Holmberg, Scott D. CA Chronic Hepatitis Cohort Study TI Predictors of Poor Mental and Physical Health Status Among Patients With Chronic Hepatitis C Infection: The Chronic Hepatitis Cohort Study (CHeCS) SO HEPATOLOGY LA English DT Article ID QUALITY-OF-LIFE; GENOTYPE 1 PATIENTS; UNITED-STATES; PEGYLATED INTERFERON; PSYCHOSOCIAL FACTORS; DISEASE PROGRESSION; COST-EFFECTIVENESS; PROBLEM DRINKING; VIRUS-INFECTION; IMPACT AB Our objective was to assess the extent and risk factors for depression and poor physical health among patients with chronic hepatitis C virus (HCV) infection. We surveyed HCV-infected patients seen at four large healthcare systems participating in the Chronic Hepatitis Cohort Study (CHeCS). Survey data included demographics, depression and physical health measures, substance use history, current social support, recent stressor exposures, and, from the electronic medical record, treatment history, and Charlson Comorbidity Index scores. There were 4,781 respondents, who were a mean of 56.7 years old, 71% White, and 57% male. Altogether, 51.4% reported past injection drug use, 33.9% were current smokers, and 17.7% had abused alcohol in the previous year. Additionally, 47.4% had been previously treated for HCV and 14.8% had a 12-week sustained viral response (SVR) following HCV therapy. Overall, 29.7% of patients met criteria for current depression and 24.6% were in poor physical health. In multivariate analyses, significant predictors of depression and poor health included: male gender (versus female, odds ratios [ORs], 0.70 and 0.81), Black race (versus white, ORs, 0.60 and 0.61), having education less than high school (versus college, ORs, 1.81 and 1.54), being employed (versus not, ORs, 0.36 and 0.25), having high life stressors (versus low, ORs, 2.44 and 1.64), having low social support (versus high, ORs=2.78 and 1.40), and having high Charlson scores (versus none, ORs=1.58 and 2.12). Achieving a 12-week SVR was found to be protective for depression. Conclusion: This large survey of U.S. HCV patients indicates the extent of adverse health behaviors and mental and physical comorbidities among these patients. (Hepatology 2015;61:802-811) C1 [Boscarino, Joseph A.] Geisinger Hlth Syst, Danville, PA USA. [Lu, Mei; Gordon, Stuart C.; Rupp, Loralee B.] Henry Ford Hlth Syst, Detroit, MI USA. [Moorman, Anne C.; Spradling, Philip R.; Teshale, Eyasu H.; Holmberg, Scott D.] Ctr Dis Control & Prevent, Div Viral Hepatitis, Natl Ctr HIV Hepatitis STD & TB Prevent, Atlanta, GA USA. [Schmidt, Mark A.] Kaiser Permanente Northwest, Portland, OR USA. [Vijayadeva, Vinutha] Kaiser Permanente Hawaii, Honolulu, HI USA. RP Boscarino, JA (reprint author), Weis Ctr Res, Geisinger Clin, Ctr Hlth Res, 100 N Acad Ave,MC 44-00, Danville, PA 17822 USA. EM jaboscarino@geisinger.edu FU CDC Foundation; AbbVie; Gilead Sciences; Janssen Pharmaceuticals, Inc.; Genentech, a Member of the Roche Group; Vertax Pharmaceuticals; Bristol-Myers Squibb FX CHeCS is funded by the CDC Foundation, which currently receives grants from AbbVie, Gilead Sciences, and Janssen Pharmaceuticals, Inc. Past funders include Genentech, a Member of the Roche Group and Vertax Pharmaceuticals. Past partial funders include Bristol-Myers Squibb. Granting corporations did not have access to CHeCS data and did not contribute to data analysis or writing of this article. NR 43 TC 14 Z9 15 U1 2 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-9139 EI 1527-3350 J9 HEPATOLOGY JI Hepatology PD MAR PY 2015 VL 61 IS 3 BP 802 EP 811 DI 10.1002/hep.27422 PG 10 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA CC2BS UT WOS:000350150300013 PM 25203533 ER PT J AU Kittikraisak, W Suntarattiwong, P Levy, J Fernandez, S Dawood, FS Olsen, SJ Chotpitayasunondh, T AF Kittikraisak, Wanitchaya Suntarattiwong, Piyarat Levy, Jens Fernandez, Stefan Dawood, Fatimah S. Olsen, Sonja J. Chotpitayasunondh, Tawee TI Influenza vaccination coverage and effectiveness in young children in Thailand, 2011-2013 SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article DE Influenza; vaccination; coverage; effectiveness; Thailand; children ID AGED 6-23 MONTHS; LABORATORY-CONFIRMED INFLUENZA; UNITED-STATES; SEASON; IMMUNIZATION; EFFICACY; HOSPITALIZATION; OUTPATIENT; COMMUNITY; VACCINES AB BackgroundSince 2009, Thailand has recommended influenza vaccine for children aged 6months through 2years, but no estimates of influenza vaccine coverage or effectiveness are available for this target group. MethodsDuring August 2011-May 2013, high-risk and healthy children aged 36months were enrolled in a 2-year prospective cohort study. Parents were contacted weekly about acute respiratory illness (ARI) in their child. Ill children had combined nasal and throat swabs tested for influenza viruses by real-time reverse transcription-polymerase chain reaction. Influenza vaccination status was verified with vaccination cards. The Cox proportional hazards approach was used to estimate hazard ratios. Vaccine effectiveness (VE) was estimated as 100% x (1-hazard ratio). ResultsDuring 2011-2013, 968 children were enrolled (median age, 103months); 948 (979%) had a vaccination record and were included. Of these, 394 (416%) had 1 medical conditions. Vaccination coverage for the 2011-2012 and 2012-2013 seasons was 293% (93/317) and 300% (197/656), respectively. In 2011-2012, there were 213 ARI episodes, of which 10 (46%) were influenza positive (23 per 1000 vaccinated and 38 per 1000 unvaccinated child-weeks). The VE was 55% (95% confidence interval [CI], -72, 88). In 2012-2013, there were 846 ARIs, of which 52 (62%) were influenza positive (18 per 1000 vaccinated and 45 per 1000 unvaccinated child-weeks). The VE was 64% (CI, 13%, 85%). ConclusionInfluenza vaccination coverage among young children in Thailand was low, although vaccination was moderately effective. Continued efforts are needed to increase influenza vaccination coverage and evaluate VE among young children in Thailand. C1 [Kittikraisak, Wanitchaya; Levy, Jens; Olsen, Sonja J.] Thailand Minist Publ Hlth US Ctr Dis Control & Pr, Influenza Program, Nonthaburi, Thailand. [Suntarattiwong, Piyarat; Chotpitayasunondh, Tawee] Minist Publ Hlth, Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Fernandez, Stefan] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Dawood, Fatimah S.; Olsen, Sonja J.] US Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. RP Kittikraisak, W (reprint author), Minist Publ Hlth, Thailand MOPH US CDC Collaborat, DDC Bldg 7,Tiwanon Rd, Nonthaburi 11000, Thailand. EM glr9@cdc.gov FU U.S. Centers for Disease Control and Prevention [5U01GH000152] FX This project was funded by U.S. Centers for Disease Control and Prevention through cooperative agreement 5U01GH000152. All authors have no financial relationships relevant to this article to disclose. NR 43 TC 6 Z9 6 U1 2 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1750-2640 EI 1750-2659 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD MAR PY 2015 VL 9 IS 2 BP 85 EP 93 DI 10.1111/irv.12302 PG 9 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA CC4TQ UT WOS:000350347100005 PM 25557920 ER PT J AU Phengxay, M Mirza, SA Reyburn, R Xeuatvongsa, A Winter, C Lewis, H Olsen, SJ Tsuyuoka, R Khanthamaly, V Palomeque, FS Bresee, JS Moen, AC Corwin, AL AF Phengxay, Manilay Mirza, Sara A. Reyburn, Rita Xeuatvongsa, Anonh Winter, Christian Lewis, Hannah Olsen, Sonja J. Tsuyuoka, Reiko Khanthamaly, Viengphone Palomeque, Francisco S. Bresee, Joseph S. Moen, Ann C. Corwin, Andrew L. CA Lao PDR Field Epidemiology Trainin TI Introducing seasonal influenza vaccine in low-income countries: an adverse events following immunization survey in the Lao People's Democratic Republic SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article DE Adverse events following immunization; influenza vaccine; Lao PDR ID PLACEBO-CONTROLLED TRIAL; ADULTS AB ObjectiveIn 2012, Lao PDR introduced seasonal influenza vaccine in pregnant women, persons aged 50years, persons with chronic diseases, and healthcare personnel. We assessed adverse events following immunization (AEFI). MethodsWe used a multistage randomized cluster sample design to interview vaccine recipients. FindingsBetween April and May 2012, 355902 were vaccinated. Of 2089 persons interviewed, 261 (125%) reported one or more AEFI. The most commonly reported AEFIs were local reactions. No hospitalizations or deaths were reported; 16% sought medical care. Acceptance and awareness of vaccination were high. ConclusionsFollowing the introduction of seasonal influenza vaccine in Lao PDR, self-reported adverse events were mild. C1 [Phengxay, Manilay; Reyburn, Rita; Winter, Christian; Lewis, Hannah; Tsuyuoka, Reiko] WHO, Western Pacific Reg Off, Lao PDR Country Off, Viangchan, Laos. [Mirza, Sara A.; Olsen, Sonja J.; Palomeque, Francisco S.; Bresee, Joseph S.; Moen, Ann C.] US Ctr Dis Control & Prevent CDC, Influenza Div, Atlanta, GA USA. [Xeuatvongsa, Anonh] Lao PDR Minist Hlth, Natl Immunizat Program, Viangchan, Laos. [Khanthamaly, Viengphone; Corwin, Andrew L.] US Ctr Dis Control & Prevent, Lao PDR Country Off, Atlanta, GA USA. RP Phengxay, M (reprint author), WHO, Western Pacific Reg, Lao PDR Country Off, POB 343, Viangchan, Laos. EM PhengxayM@wpro.who.int FU Centers for Disease Control and Prevention [5U51IP 000583]; government of Lao PDR FX This project was funded by the Centers for Disease Control and Prevention (cooperative agreement number 5U51IP 000583) and the government of Lao PDR. NR 14 TC 2 Z9 2 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1750-2640 EI 1750-2659 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD MAR PY 2015 VL 9 IS 2 BP 94 EP 98 DI 10.1111/irv.12299 PG 5 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA CC4TQ UT WOS:000350347100006 PM 25598475 ER PT J AU Smith, DK Herbst, JH Zhang, XJ Rose, CE AF Smith, Dawn K. Herbst, Jeffrey H. Zhang, Xinjiang Rose, Charles E. TI Condom Effectiveness for HIV Prevention by Consistency of Use Among Men Who Have Sex With Men in the United States SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE MSM; HIV; condom; effectiveness ID ANAL INTERCOURSE; PREEXPOSURE PROPHYLAXIS; TRANSMISSION RISK; INFECTION; ACQUISITION; PREVALENCE; TRIAL; ACT AB Objective:We derived an estimate of male condom effectiveness during anal sex among men who have sex with men (MSM) because the most widely used estimate of condom effectiveness (80%) was based on studies of persons during heterosexual sex with an HIV-positive partner.Design:Assessed male condom effectiveness during anal sex between MSM in 2 prospective cohort studies of HIV incidence by self-reported consistency of use.Methods:Analyzed data combined from US participants in the EXPLORE trial (1999-2001) public use data set and in the VAX 004 trial (1998-1999) data set. Initially, HIV-uninfected MSM enrolled in these trials completed baseline and semiannual interviews about their sexual behaviors with male partners and underwent HIV testing. Using a time-to-event model, effectiveness of consistent condom use in preventing HIV infection was estimated among men reporting receptive and/or insertive anal sex with an HIV-positive partner and consistency of condom use.Results:Among MSM reporting any anal sex with an HIV-positive male partner, we found 70% effectiveness with reported consistent condom use (compared with never use) and no significant protection when comparing sometimes use to never use. This point estimate for MSM was less than the 80% effectiveness estimate reported for heterosexuals in HIV-discordant couples reporting consistent condom use. However, the point estimates in the 2 populations are not statistically different. Only 16% of MSM reported consistent condom use during anal sex with male partners of any HIV status over the entire observation period.Conclusions:These estimates are useful for counseling efforts and for modeling the impact and comparative effectiveness of condoms and other prevention methods used by MSM. C1 [Smith, Dawn K.; Herbst, Jeffrey H.; Zhang, Xinjiang; Rose, Charles E.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, NCHHSTP, Atlanta, GA 30333 USA. RP Smith, DK (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,MS E-45, Atlanta, GA 30333 USA. EM dsmith1@cdc.gov NR 28 TC 19 Z9 22 U1 2 U2 12 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD MAR 1 PY 2015 VL 68 IS 3 BP 337 EP 344 DI 10.1097/QAI.0000000000000461 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CC3JZ UT WOS:000350245400020 PM 25469526 ER PT J AU Shrestha, RK Gardner, L Marks, G Craw, J Malitz, F Giordano, TP Sullivan, M Keruly, J Rodriguez, A Wilson, TE Mugavero, M AF Shrestha, Ram K. Gardner, Lytt Marks, Gary Craw, Jason Malitz, Faye Giordano, Thomas P. Sullivan, Meg Keruly, Jeanne Rodriguez, Allan Wilson, Tracey E. Mugavero, Michael TI Estimating the Cost of Increasing Retention in Care for HIV-Infected Patients: Results of the CDC/HRSA Retention in Care Trial SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV; retention in care; microcosting; cost study ID ANTIRETROVIRAL THERAPY; UNITED-STATES; PREVENTION; INTERVENTIONS; SUPPRESSION; US AB Background:Retaining HIV patients in medical care promotes access to antiretroviral therapy, viral load suppression, and reduced HIV transmission to partners. We estimate the programmatic costs of a US multisite randomized controlled trial of an intervention to retain HIV patients in care.Methods:Six academically affiliated HIV clinics randomized patients to intervention (enhanced personal contact with patients across time coupled with basic HIV education) and control [standard of care (SOC)] arms. Retention in care was defined as 4-month visit constancy, that is, at least 1 primary care visit in each 4-month interval over a 12-month period. We used microcosting methods to collect unit costs and measure the quantity of resources used to implement the intervention in each clinic. All fixed and variable labor and nonlabor costs of the intervention were included.Results:Visit constancy was achieved by 45.7% (280/613) of patients in the SOC arm and by 55.8% (343/615) of patients in the intervention arm, representing an increase of 63 patients (relative improvement 22.1%; 95% confidence interval: 9% to 36%; P < 0.01). The total annual cost of the intervention at the 6 clinics was $241,565, the average cost per patient was $393, and the estimated cost per additional patient retained in care beyond SOC was $3834.Conclusions:Our analyses showed that a retention in care intervention consisting of enhanced personal contact coupled with basic HIV education may be delivered at fairly low cost. These results provide useful information for guiding decisions about planning or scaling-up retention in care interventions for HIV-infected patients. C1 [Shrestha, Ram K.; Gardner, Lytt; Marks, Gary; Craw, Jason] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Off Infect Dis, Atlanta, GA 30333 USA. [Malitz, Faye] US Hlth Resources & Serv Adm, HIV AIDS Bur, Rockville, MD USA. Baylor Coll Med, Dept Med, Houston, TX 77030 USA. [Giordano, Thomas P.] Michael E DeBakey VA Med Ctr, Ctr Innovat Qual Effectiveness & Safety, Houston, TX USA. [Sullivan, Meg] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA. [Keruly, Jeanne] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA. [Rodriguez, Allan] Univ Miami, Miller Sch Med, Div Infect Dis, Miami, FL 33136 USA. [Wilson, Tracey E.] Suny Downstate Med Ctr, Dept Community Hlth Sci, Sch Publ Hlth, Brooklyn, NY 11203 USA. [Mugavero, Michael] Univ Alabama Birmingham, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA. RP Shrestha, RK (reprint author), Ctr Dis Control & Prevent, Mail Stop E48,1600 Clifton Rd, Atlanta, GA 30333 USA. EM biu0@cdc.gov FU Centers for Disease Control and Prevention (CDC); Health Resources and Services Administration (HRSA) [200-2007-23685, 200-2007-23690, 200-2007-23689, 200-2007-23687, 200-2007-23684, 200-2007-23692]; BMS; Gilead; Merck; ViiV; Jannsen; GSK FX Supported by the Centers for Disease Control and Prevention (CDC) and the Health Resources and Services Administration (HRSA) (contracts 200-2007-23685, 200-2007-23690, 200-2007-23689, 200-2007-23687, 200-2007-23684, and 200-2007-23692).; M.S. has received institutional grant support from BMS, Gilead, Merck, ViiV, Jannsen, and GSK. The remaining authors have no conflicts of interest to disclose. NR 25 TC 3 Z9 3 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD MAR 1 PY 2015 VL 68 IS 3 BP 345 EP 350 DI 10.1097/QAI.0000000000000462 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CC3JZ UT WOS:000350245400021 PM 25469520 ER PT J AU Woldesenbet, SA Jackson, D Goga, AE Crowley, S Doherty, T Mogashoa, MM Dinh, TH Sherman, GG AF Woldesenbet, Selamawit A. Jackson, Debra Goga, Ameena E. Crowley, Siobhan Doherty, Tanya Mogashoa, Mary M. Thu-Ha Dinh Sherman, Gayle G. TI Missed Opportunities for Early Infant HIV Diagnosis: Results of A National Study in South Africa SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE EID service; PICT; missed opportunities; HIV-exposed infants; mother-to-child HIV transmission ID TO-CHILD TRANSMISSION; FOLLOW-UP; ANTIRETROVIRAL THERAPY; IMMUNIZATION CLINICS; INFECTED CHILDREN; RURAL MALAWI; PREVENTION; PROGRAMS; CARE; CHALLENGES AB Background:Services to diagnose early infant HIV infection should be offered at the 6-week immunization visit. Despite high 6-week immunization attendance, the coverage of early infant diagnosis (EID) is low in many sub-Saharan countries. We explored reasons for such missed opportunities at 6-week immunization visits.Methods:We used data from 2 cross-sectional surveys conducted in 2010 in South Africa. A national assessment was undertaken among randomly selected public facilities (n = 625) to ascertain procedures for EID. A subsample of these facilities (n = 565) was revisited to assess the HIV status of 4- to 8-week-old infants receiving 6-week immunization. We examined potential missed opportunities for EID. We used logistic regression to assess factors influencing maternal intention to report for EID at 6-week immunization visits.Results:EID services were available in >95% of facilities and 72% of immunization service points (ISPs). The majority (68%) of ISPs provide EID for infants with reported or documented (on infant's Road-to-Health Chart/bookletiRtHC) HIV exposure. Only 9% of ISPs offered provider-initiated counseling and testing for infants of undocumented/unknown HIV exposure. Interviews with self-reported HIV-positive mothers at ISPs revealed that only 55% had their HIV status documented on their iRtHC and 35% intended to request EID during 6-week immunization. Maternal nonreporting for EID was associated with fear of discrimination, poor adherence to antiretrovirals, and inadequate knowledge about mother-to-child HIV transmission.Conclusions:Missed opportunities for EID were attributed to poor documentation of HIV status on iRtHC, inadequate maternal knowledge about mother-to-child HIV transmission, fear of discrimination, and the lack of provider-initiated counseling and testing service for undocumented, unknown, or undeclared HIV-exposed infants. C1 [Woldesenbet, Selamawit A.; Goga, Ameena E.; Doherty, Tanya] South African Med Res Council, MRC, Hlth Syst Res Unit, ZA-7505 Cape Town, South Africa. [Jackson, Debra; Doherty, Tanya] Univ Western Cape, Sch Publ Hlth, ZA-7535 Bellville, South Africa. [Jackson, Debra] UNICEF, New York, NY USA. [Goga, Ameena E.] Univ Pretoria, Kalafong Hosp, Dept Paediat & Child Hlth, ZA-0002 Pretoria, South Africa. [Crowley, Siobhan] ELMA Philanthropies, New York, NY USA. [Doherty, Tanya] Univ Witwatersrand, Sch Publ Hlth, Johannesburg, South Africa. [Mogashoa, Mary M.] Ctr Dis Control & Prevent, Pretoria, South Africa. [Thu-Ha Dinh] Ctr Dis Control & Prevent, Ctr Global Hlth, Div Global HIV AIDS, Atlanta, GA USA. [Sherman, Gayle G.] Natl Inst Communicable Dis, Ctr HIV & STI, Johannesburg, South Africa. [Sherman, Gayle G.] Univ Witwatersrand, Dept Paediat & Child Hlth, Fac Hlth Sci, Johannesburg, South Africa. RP Woldesenbet, SA (reprint author), South African Med Res Council, Hlth Syst Res Unit, Francie van Zyl Dr, ZA-7505 Cape Town, South Africa. EM woldeselam@gmail.com FU President's Emergency Plan for AIDS Relief through the Centers for Disease Control and Prevention [1U2GPS001137-02, 1U2GPS001137-03]; National Department of Health; United Nations Children's Fund; National Research Foundation; Clinton Health Access Initiative; African Doctoral Dissertation Research Fellowship; South African Centre for Epidemiological Modeling and Analysis FX Supported by the President's Emergency Plan for AIDS Relief through the Centers for Disease Control and Prevention under the terms of Cooperative Agreements 1U2GPS001137-02 and 1U2GPS001137-03, the National Department of Health, United Nations Children's Fund, The National Research Foundation, the Clinton Health Access Initiative, African Doctoral Dissertation Research Fellowship, and South African Centre for Epidemiological Modeling and Analysis. NR 38 TC 8 Z9 8 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD MAR 1 PY 2015 VL 68 IS 3 BP e26 EP e32 DI 10.1097/QAI.0000000000000460 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CC3JZ UT WOS:000350245400001 PM 25469521 ER PT J AU Hampton, LM Daubresse, M Chang, HY Alexander, GC Budnitz, DS AF Hampton, Lee M. Daubresse, Matthew Chang, Hsien-Yen Alexander, G. Caleb Budnitz, Daniel S. TI Emergency Department Visits by Children and Adolescents for Antipsychotic Drug Adverse Events SO JAMA PSYCHIATRY LA English DT Letter ID ADULTS C1 [Hampton, Lee M.; Budnitz, Daniel S.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30329 USA. [Daubresse, Matthew; Alexander, G. Caleb] Johns Hopkins Univ, Ctr Drug Safety & Effectiveness, Baltimore, MD USA. [Chang, Hsien-Yen] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Baltimore, MD USA. RP Hampton, LM (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,MS A-4, Atlanta, GA 30329 USA. EM lhampton@cdc.gov RI Chang, Hsien-Yen/E-4627-2014 OI Chang, Hsien-Yen/0000-0002-7997-4822 FU Intramural CDC HHS [CC999999] NR 6 TC 2 Z9 2 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-622X EI 2168-6238 J9 JAMA PSYCHIAT JI JAMA Psychiatry PD MAR PY 2015 VL 72 IS 3 BP 292 EP 294 DI 10.1001/jamapsychiatry.2014.2412 PG 3 WC Psychiatry SC Psychiatry GA CC7UJ UT WOS:000350573600013 PM 25588054 ER PT J AU McGonagle, AK Fisher, GG Barnes-Farrell, JL Grosch, JW AF McGonagle, Alyssa K. Fisher, Gwenith G. Barnes-Farrell, Janet L. Grosch, James W. TI Individual and Work Factors Related to Perceived Work Ability and Labor Force Outcomes SO JOURNAL OF APPLIED PSYCHOLOGY LA English DT Article DE perceived work ability; older workers; job demands-resources model; personal resources; Health and Retirement Study ID SELF-RATED HEALTH; JOB DEMANDS; MUNICIPAL OCCUPATIONS; DEPRESSIVE SYMPTOMS; METAANALYSIS; RESOURCES; BURNOUT; STRESS; AGE; MODEL AB Perceived work ability refers to a worker's assessment of his or her ability to continue working in his or her job, given characteristics of the job along with his or her resources. Perceived work ability is a critical variable to study in the United States, given an aging workforce, trends to delay retirement, and U.S. policy considerations to delay the age at which full Social Security retirement benefits may be obtained. Based on the job demands-resources model, cognitive appraisal theory of stress, and push/pull factors related to retirement, we proposed and tested a conceptual model of antecedents and outcomes of perceived work ability using 3 independent samples of U.S. working adults. Data regarding workers' job characteristics were from self-report and Occupational Information Network measures. Results from relative importance analysis indicated that health and sense of control were consistently and most strongly related to work ability perceptions relative to other job demands and job and personal resources when perceived work ability was measured concurrently or 2 weeks later in samples with varying occupations. Job demands (along with health and sense of control) were most strongly related to work ability perceptions when perceived work ability was measured in a manufacturing worker sample 1.6 years later. Perceived work ability also predicted lagged labor force outcomes (absence, retirement, and disability leave) while controlling for other known predictors of each. Consistent indirect effects were observed from health status and sense of control to all 3 of these outcomes via perceived work ability. C1 [McGonagle, Alyssa K.] Wayne State Univ, Dept Psychol, Detroit, MI 48202 USA. [Fisher, Gwenith G.] Colorado State Univ, Dept Psychol, Ft Collins, CO 80523 USA. [Barnes-Farrell, Janet L.] Univ Connecticut, Dept Psychol, Storrs, CT USA. [Grosch, James W.] NIOSH, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. RP McGonagle, AK (reprint author), Wayne State Univ, Dept Psychol, 5057 Woodward Ave,Seventh Floor, Detroit, MI 48202 USA. EM alyssa.mcgonagle@wayne.edu FU National Institute for Occupational Safety and Health [R01 OH OH008929, CDC-NIOSH 254-2010-M-37002]; National Institute on Aging [U01 AG009740, P30 AG12846]; Michigan Center for the Demography of Aging FX This publication was supported by the National Institute for Occupational Safety and Health (R01 OH OH008929), the National Institute on Aging (U01 AG009740), and a pilot grant from the Michigan Center for the Demography of Aging, which is sponsored by the National Institute on Aging (P30 AG12846). Funding for the data linkage of HRS and O*NET was provided by the National Institute for Occupational Safety and Health (CDC-NIOSH 254-2010-M-37002). The findings and conclusions in this article are those of the authors and do not necessarily reflect the official positions of the Centers for Disease Control and Prevention or the National Institute for Occupational Safety and Health. We thank Lisa Marchiondo for her work in conducting the HRS-O*NET linkage and Lauren Cotter for help in preparing the article. NR 105 TC 13 Z9 13 U1 6 U2 43 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0021-9010 EI 1939-1854 J9 J APPL PSYCHOL JI J. Appl. Psychol. PD MAR PY 2015 VL 100 IS 2 BP 376 EP 398 DI 10.1037/a0037974 PG 23 WC Psychology, Applied; Management SC Psychology; Business & Economics GA CC7NB UT WOS:000350553700006 PM 25314364 ER PT J AU Taylor, SM Parobek, CM DeConti, DK Kayentao, K Coulibaly, SO Greenwood, BM Tagbor, H Williams, J Bojang, K Njie, F Desai, M Kariuki, S Gutman, J Mathanga, DP Martensson, A Ngasala, B Conrad, MD Rosenthal, PJ Tshefu, AK Moormann, AM Vulule, JM Doumbo, OK ter Kuile, FO Meshnick, SR Bailey, JA Juliano, JJ AF Taylor, Steve M. Parobek, Christian M. DeConti, Derrick K. Kayentao, Kassoum Coulibaly, Sheick Oumar Greenwood, Brian M. Tagbor, Harry Williams, John Bojang, Kalifa Njie, Fanta Desai, Meghna Kariuki, Simon Gutman, Julie Mathanga, Don P. Martensson, Andreas Ngasala, Billy Conrad, Melissa D. Rosenthal, Philip J. Tshefu, Antoinette K. Moormann, Ann M. Vulule, John M. Doumbo, Ogobara K. ter Kuile, Feiko O. Meshnick, Steven R. Bailey, Jeffrey A. Juliano, Jonathan J. TI Absence of Putative Artemisinin Resistance Mutations Among Plasmodium falciparum in Sub-Saharan Africa: A Molecular Epidemiologic Study SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE falciparum malaria; artemisinin resistance; drug resistance; molecular epidemiology ID DRUG-RESISTANCE; MALARIA; ARTESUNATE; CLEARANCE; DIVERSITY; CHILDREN; MARKER; TOOL AB Plasmodium falciparum parasites that are resistant to artemisinins have been detected in Southeast Asia. Resistance is associated with several polymorphisms in the parasite's K13-propeller gene. The molecular epidemiology of these artemisinin resistance genotypes in African parasite populations is unknown. We developed an assay to quantify rare polymorphisms in parasite populations that uses a pooled deep-sequencing approach to score allele frequencies, validated it by evaluating mixtures of laboratory parasite strains, and then used it to screen P. falciparum parasites from >1100 African infections collected since 2002 from 14 sites across sub-Saharan Africa. We found no mutations in African parasite populations that are associated with artemisinin resistance in Southeast Asian parasites. However, we observed 15 coding mutations, including 12 novel mutations, and limited allele sharing between parasite populations, consistent with a large reservoir of naturally occurring K13-propeller variation. Although polymorphisms associated with artemisinin resistance in P. falciparum in Southeast Asia are not prevalent in sub-Saharan Africa, numerous K13-propeller coding polymorphisms circulate in Africa. Although their distributions do not support a widespread selective sweep for an artemisinin-resistant phenotype, the impact of these mutations on artemisinin susceptibility is unknown and will require further characterization. Rapid, scalable molecular surveillance offers a useful adjunct in tracking and containing artemisinin resistance. C1 [Taylor, Steve M.] Duke Univ, Med Ctr, Dept Med, Div Infect Dis, Durham, NC 27710 USA. [Taylor, Steve M.] Duke Univ, Med Ctr, Duke Global Hlth Inst, Durham, NC USA. [Taylor, Steve M.; Meshnick, Steven R.] Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA. [Parobek, Christian M.; Juliano, Jonathan J.] Univ N Carolina, Curriculum Genet & Mol Biol, Sch Med, Chapel Hill, NC USA. [Juliano, Jonathan J.] Univ N Carolina, Sch Med, Div Infect Dis, Chapel Hill, NC USA. [DeConti, Derrick K.] Univ Massachusetts, Sch Med, Grad Sch Biomed Sci, Worcester, MA USA. [Moormann, Ann M.] Univ Massachusetts, Sch Med, Dept Pediat, Worcester, MA USA. [Bailey, Jeffrey A.] Univ Massachusetts, Sch Med, Div Transfus Med, Worcester, MA USA. [Bailey, Jeffrey A.] Univ Massachusetts, Sch Med, Program Bioinformat & Integrat Biol, Worcester, MA USA. [Desai, Meghna; Gutman, Julie] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA USA. [Conrad, Melissa D.; Rosenthal, Philip J.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA. [Kayentao, Kassoum; Doumbo, Ogobara K.] Univ Sci Tech & Technol Bamako, Fac Med Pharm & Odontostomatol, Malaria Res & Training Ctr, Dept Epidemiol Parasit Dis, Bamako, Mali. [Kayentao, Kassoum; ter Kuile, Feiko O.] Univ Liverpool, Liverpool Sch Trop Med, Dept Clin Sci, Liverpool L3 5QA, Merseyside, England. [Greenwood, Brian M.] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, London WC1, England. [Coulibaly, Sheick Oumar] Univ Ouagadougou, Fac Hlth Sci, Ouagadougou, Burkina Faso. [Tagbor, Harry] Kwame Nkrumah Univ Sci & Technol, Sch Med Sci, Dept Community Hlth, Kumasi, Ghana. [Williams, John] Ghana Hlth Serv, Navrongo Hlth Res Ctr, Navrongo, Ghana. [Bojang, Kalifa; Njie, Fanta] MRC Labs, Banjul, Gambia. [Desai, Meghna] CDC Kenya, Kisumu, Kenya. [Kariuki, Simon] CDC, KEMRI, Kisumu, Kenya. [Vulule, John M.; ter Kuile, Feiko O.] KEMRI, Ctr Global Hlth Res, Kisumu, Kenya. [Mathanga, Don P.] Univ Malawi, Coll Med, Malaria Alert Ctr, Blantyre, Malawi. [Mathanga, Don P.] Coll Med, Dept Community Hlth, Lilongwe, Malawi. [Martensson, Andreas] Karolinska Inst, Dept Med Solna, Malaria Res, Stockholm, Sweden. [Martensson, Andreas] Karolinska Inst, Dept Publ Hlth Sci, Global Hlth, Stockholm, Sweden. [Ngasala, Billy] Muhumbili Univ Hlth & Allied Sci, Dept Parasitol, Dar Es Salaam, Tanzania. [Tshefu, Antoinette K.] Univ Kinshasa, Fac Med, Ecole Sante Publ, Kinshasa, DEM REP CONGO. RP Juliano, JJ (reprint author), Div Infect Dis, CB 7030, Chapel Hill, NC 27599 USA. EM jjuliano@med.unc.edu OI ter Kuile, Feiko/0000-0003-3663-5617 FU National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [K08AI10092, R01AI089819, R56AI097909, U19AI089674]; NIH [KL2RR031981, T32GM0088719]; Malaria in Pregnancy Consortium - Bill and Melinda Gates Foundation [46099] FX This work was supported by the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH; grants K08AI100924 [to S. M. T.], R01AI089819 [to J. J. J.], R56AI097909 [to S. R. M.], and U19AI089674), the NIH (KL2RR031981 to J. A. B. and training grant T32GM0088719 to C. M. P.), and the Malaria in Pregnancy Consortium, which is funded through a grant from the Bill and Melinda Gates Foundation to the Liverpool School of Tropical Medicine (grant 46099 to F. O. t. K.). Additional sources of funding for the original clinical studies are specified in Supplementary Table 1. NR 31 TC 68 Z9 70 U1 2 U2 13 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD MAR 1 PY 2015 VL 211 IS 5 BP 680 EP 688 DI 10.1093/infdis/jiu467 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CC3CL UT WOS:000350222000003 PM 25180240 ER PT J AU Hegde, M Bale, S Bayrak-Toydemir, P Gibson, J Jeng, LJB Joseph, L Laser, J Lubin, IM Miller, CE Ross, LF Rothberg, PG Tanner, AK Vitazka, P Mao, R AF Hegde, Madhuri Bale, Sherri Bayrak-Toydemir, Pinar Gibson, Jane Jeng, Linda Jo Bone Joseph, Loren Laser, Jordan Lubin, Ira M. Miller, Christine E. Ross, Lainie F. Rothberg, Paul G. Tanner, Alice K. Vitazka, Patrik Mao, Rong TI Reporting Incidental Findings in Genomic Scale Clinical Sequencing-A Clinical Laboratory Perspective A Report of the Association for Molecular Pathology SO JOURNAL OF MOLECULAR DIAGNOSTICS LA English DT Article ID ACMG RECOMMENDATIONS; PATIENT AUTONOMY; MEDICINE; EXOME; STANDARDS; RETURN AB Advances in sequencing technologies have facilitated concurrent testing for many disorders, and the results generated may provide information about a patient's health that is unrelated to the clinical indication, commonly referred to as incidental findings. This is a paradigm shift from traditional genetic testing in which testing and reporting are tailored to a patient's specific clinical condition. Clinical laboratories and physicians are wrestling with this increased complexity in genomic testing and reporting of the incidental findings to patients. An enormous amount of discussion has taken place since the release of a set of recommendations from the American College of Medical Genetics and Genomics. This discussion has largely focused on the content of the incidental findings, but the laboratory perspective and patient autonomy have been overlooked. This report by the Association of Molecular Pathology workgroup discusses the pros and cons of next-generation sequencing technology, potential benefits, and harms for reporting of incidental findings, including the effect on both the laboratory and the patient, and compares those with other areas of medicine. The importance of genetic counseling to preserve patient autonomy is also reviewed. The discussion and recommendations presented by the workgroup underline the need for continued research and discussion among all stakeholders to improve our understanding of the effect of different policies on patients, providers, and laboratories. C1 [Hegde, Madhuri; Bale, Sherri; Bayrak-Toydemir, Pinar; Gibson, Jane; Jeng, Linda Jo Bone; Joseph, Loren; Laser, Jordan; Lubin, Ira M.; Miller, Christine E.; Ross, Lainie F.; Rothberg, Paul G.; Tanner, Alice K.; Vitazka, Patrik; Mao, Rong] Clin Practice Comm, Incidental Findings Working Grp, AMP, Bethesda, MD USA. [Hegde, Madhuri; Bale, Sherri; Bayrak-Toydemir, Pinar; Gibson, Jane; Jeng, Linda Jo Bone; Joseph, Loren; Laser, Jordan; Lubin, Ira M.; Miller, Christine E.; Ross, Lainie F.; Rothberg, Paul G.; Tanner, Alice K.; Vitazka, Patrik; Mao, Rong] Whole Genome Anal Working Grp, Bethesda, MD USA. [Hegde, Madhuri; Tanner, Alice K.] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30022 USA. [Hegde, Madhuri; Tanner, Alice K.] Emory Univ, Emory Genet Lab, Decatur, GA USA. [Bale, Sherri; Vitazka, Patrik] GeneDx, Gaithersburg, MD USA. [Bayrak-Toydemir, Pinar; Mao, Rong] Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT USA. [Bayrak-Toydemir, Pinar; Miller, Christine E.; Mao, Rong] ARUP Labs, Dept Mol Genet, Salt Lake City, UT USA. [Gibson, Jane] Univ Cent Florida, Coll Med, Dept Clin Sci, Orlando, FL 32816 USA. [Jeng, Linda Jo Bone] Univ Maryland, Sch Med, Dept Pathol, Dept Med,Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA. [Jeng, Linda Jo Bone] Univ Maryland, Sch Med, Dept Pediat, Div Human Genet, Baltimore, MD 21201 USA. [Joseph, Loren] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA. [Ross, Lainie F.] Univ Chicago, Dept Pediat, Chicago, IL 60637 USA. [Laser, Jordan] North Shore Long Isl Jewish Hlth Syst, Div Cytogenet & Mol Pathol, New Hyde Pk, NY USA. [Lubin, Ira M.] Ctr Dis Control & Prevent, Div Lab Programs Standards & Serv, Atlanta, GA USA. [Ross, Lainie F.] Univ Chicago, MacLean Ctr Clin Med Eth, Chicago, IL 60637 USA. [Rothberg, Paul G.] Univ Rochester, Sch Med & Dent, Dept Pathol & Lab Med, Rochester, NY USA. RP Hegde, M (reprint author), Emory Univ, Sch Med, Dept Human Genet, 615 Michael St,Whitehead Biomed Res Bldg, Atlanta, GA 30022 USA. EM mhegde@emory.edu FU NCATS NIH HHS [UL1 TR000430] NR 32 TC 12 Z9 12 U1 3 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1525-1578 EI 1943-7811 J9 J MOL DIAGN JI J. Mol. Diagn. PD MAR PY 2015 VL 17 IS 2 BP 107 EP 117 DI 10.1016/j.jmoldx.2014.10.004 PG 11 WC Pathology SC Pathology GA CC7CV UT WOS:000350526200001 PM 25684271 ER PT J AU Zhang, X Boscardin, WJ Belin, TR Wan, XH He, YL Zhang, K AF Zhang, Xiao Boscardin, W. John Belin, Thomas R. Wan, Xiaohai He, YuLei Zhang, Kui TI A Bayesian method for analyzing combinations of continuous, ordinal, and nominal categorical data with missing values SO JOURNAL OF MULTIVARIATE ANALYSIS LA English DT Article DE Multivariate probit model; Multinomial probit model; MCMC ID LATENT VARIABLE MODELS; MULTINOMIAL PROBIT MODEL; STRUCTURAL EQUATION MODELS; LONGITUDINAL DATA-ANALYSIS; CONTINUOUS OUTCOMES; REGRESSION-MODELS; MIXED DISCRETE; POLYTOMOUS DATA; GENERAL LOCATION; LINEAR-MODELS AB From a Bayesian perspective, we propose a general method for analyzing a combination of continuous, ordinal (including binary), and categorical/nominal multivariate measures with missing values. We assume multivariate normal linear regression models for multivariate continuous measures, multivariate probit models for correlated ordinal measures, and multivariate multinomial probit models for multivariate categorical/nominal measures. Then we assume a multivariate normal linear model on the continuous vector comprised of continuous variables and those underlying normal variables for ordinal variables from multivariate probit models and for categorical variables from multinomial probit models. We develop a Markov chain Monte Carlo (MCMC) algorithm to estimate unknown parameters including regression parameters, cut-points for ordinal data from the multivariate probit models, and the covariance matrix encompassing both continuous variables and the underlying normal latent variables. Combining the continuous variables and the normal latent variables allows us to model combinations of continuous, ordinal, and categorical multivariate data simultaneously. The framework incorporates flexible priors for the covariance matrix, provides a foundation for inference about the underlying covariance structure, and imputes missing data where needed. The method is illustrated through simulated examples and two real data applications. (C) 2014 Elsevier Inc. All rights reserved. C1 [Zhang, Xiao] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA. [Boscardin, W. John] Univ San Francisco, Dept Med, San Francisco, CA 94117 USA. [Belin, Thomas R.] Univ Calif Los Angeles, Jonathan & Karin Fielding Sch Publ Hlth, Dept Biostat, Los Angeles, CA 90024 USA. [Wan, Xiaohai] AstraZeneca Pharmaceut LP, Wilmington, DE USA. [Wan, Xiaohai; Zhang, Kui] Univ Alabama Birmingham, Sch Publ Hlth, Dept Biostat, Birmingham, AL USA. [He, YuLei] Natl Ctr Hlth Stat, Ctr Dis Control & Prevent, Off Res & Methodol, Hyattsville, MD USA. RP Zhang, X (reprint author), Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA. EM xiao.zhang@cshs.org NR 70 TC 1 Z9 1 U1 3 U2 12 PU ELSEVIER INC PI SAN DIEGO PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0047-259X J9 J MULTIVARIATE ANAL JI J. Multivar. Anal. PD MAR PY 2015 VL 135 BP 43 EP 58 DI 10.1016/j.jmva.2014.11.007 PG 16 WC Statistics & Probability SC Mathematics GA CC1AN UT WOS:000350073400004 ER PT J AU Yang, H Nguyen, HT Carney, PJ Guo, Z Chang, JC Jones, J Davis, CT Villanueva, JM Gubareva, LV Stevens, J AF Yang, Hua Nguyen, Ha T. Carney, Paul J. Guo, Zhu Chang, Jessie C. Jones, Joyce Davis, Charles T. Villanueva, Julie M. Gubareva, Larisa V. Stevens, James TI Structural and Functional Analysis of Surface Proteins from an A(H3N8) Influenza Virus Isolated from New England Harbor Seals SO JOURNAL OF VIROLOGY LA English DT Article ID RECEPTOR-BINDING PROPERTIES; A VIRUS; SIALIC-ACID; EQUINE INFLUENZA; MEMBRANE-FUSION; AMINO-ACID; HEMAGGLUTININ; NEURAMINIDASE; TRANSMISSION; EVOLUTION AB In late 2011, an A(H3N8) influenza virus infection resulted in the deaths of 162 New England harbor seals. Virus sequence analysis and virus receptor binding studies highlighted potential markers responsible for mammalian adaptation and a mixed receptor binding preference (S.J. Anthony, J.A. St Leger, K. Pugliares, H.S. Ip, J.M. Chan, Z.W. Carpenter, I. Navarrete-Macias, M. Sanchez-Leon, J.T. Saliki, J. Pedersen, W. Karesh, P. Daszak, R. Rabadan, T. Rowles, W. I. Lipkin, MBio 3:e00166-00112, 2012, http://dx.doi.org/10.1128/mBio.00166-12). Here, we present a detailed structural and biochemical analysis of the surface antigens of the virus. Results obtained with recombinant proteins for both the hemagglutinin and neuraminidase indicate a true avian receptor binding preference. Although the detection of this virus in new species highlights an increased potential for crosss-pecies transmission, our results indicate that the A(H3N8) virus currently poses a low risk to humans. IMPORTANCE Cross-species transmission of zoonotic influenza viruses increases public health concerns. Here, we report a molecular and structural study of the major surface proteins from an A(H3N8) influenza virus isolated from New England harbor seals. The results improve our understanding of these viruses as they evolve and provide important information to aid ongoing risk assessment analyses as these zoonotic influenza viruses continue to circulate and adapt to new hosts. C1 [Yang, Hua; Nguyen, Ha T.; Carney, Paul J.; Guo, Zhu; Chang, Jessie C.; Jones, Joyce; Davis, Charles T.; Villanueva, Julie M.; Gubareva, Larisa V.; Stevens, James] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Nguyen, Ha T.] Battelle Mem Inst, Atlanta, GA USA. RP Stevens, J (reprint author), Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM fwb4@cdc.gov FU Centers for Disease Control and Prevention; U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-06CH11357]; DOE Office of Biological and Environmental Research; National Institutes of Health, National Institute of General Medical Sciences [P41GM103393]; National Institute of General Medical Sciences [GM62116] FX This work was funded by the Centers for Disease Control and Prevention. The U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under contract no. DE-AC02-06CH11357, supports use of the Advanced Photon Source at Argonne National Laboratory. The Stanford Synchrotron Radiation Lightsource, a Directorate of SLAC National Accelerator Laboratory, is operated for the U.S. Department of Energy Office of Science by Stanford University and is supported by the DOE Office of Biological and Environmental Research and by the National Institutes of Health, National Institute of General Medical Sciences (including P41GM103393). Glycan microarray slides were produced under contract for the Centers for Disease Control and Prevention using a glycan library generously provided by the Consortium for Functional Glycomics (CFG) (http://www.functionalglycomics.org), funded by National Institute of General Medical Sciences grant GM62116. NR 82 TC 4 Z9 4 U1 2 U2 15 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD MAR PY 2015 VL 89 IS 5 BP 2801 EP 2812 DI 10.1128/JVI.02723-14 PG 12 WC Virology SC Virology GA CC2XD UT WOS:000350207400031 PM 25540377 ER PT J AU Izurieta, HS Thadani, N Shay, DK Lu, Y Maurer, A Foppa, IM Franks, R Pratt, D Forshee, RA MaCurdy, T Worrall, C Howery, AE Kelman, J AF Izurieta, Hector S. Thadani, Nicole Shay, David K. Lu, Yun Maurer, Aaron Foppa, Ivo M. Franks, Riley Pratt, Douglas Forshee, Richard A. MaCurdy, Thomas Worrall, Chris Howery, Andrew E. Kelman, Jeffrey TI Comparative effectiveness of high-dose versus standard-dose influenza vaccines in US residents aged 65 years and older from 2012 to 2013 using Medicare data: a retrospective cohort analysis SO LANCET INFECTIOUS DISEASES LA English DT Article ID RESPIRATORY SYNCYTIAL VIRUS; PLACEBO-CONTROLLED TRIAL; ELDERLY-PEOPLE; UNITED-STATES; MORTALITY BENEFITS; SEASONAL INFLUENZA; VACCINATION; SURVEILLANCE; ADULTS; RISK AB Background A high-dose trivalent inactivated influenza vaccine was licensed in 2009 by the US Food and Drug Administration (FDA) on the basis of serological criteria. We sought to establish whether high-dose inactivated influenza vaccine was more effective for prevention of influenza-related visits and hospital admissions in US Medicare beneficiaries than was standard-dose inactivated influenza vaccine. Methods In this retrospective cohort study, we identified Medicare beneficiaries aged 65 years and older who received high-dose or standard-dose inactivated influenza vaccines from community pharmacies that offered both vaccines during the 2012-13 influenza season. Outcomes were defined with billing codes on Medicare claims. The primary outcome was probable influenza infection, defined by receipt of a rapid influenza test followed by dispensing of the neuraminidase inhibitor oseltamivir. The secondary outcome was a hospital or emergency department visit, listing a Medicare billing code for influenza. We estimated relative vaccine effectiveness by comparing outcome rates in Medicare beneficiaries during periods of high influenza circulation. Univariate and multivariate Poisson regression models were used for analyses. Findings Between Aug 1, 2012 and Jan 31, 2013, we studied 929 730 recipients of high-dose vaccine and 1 615 545 recipients of standard-dose vaccine. Participants enrolled in each cohort were well balanced with respect to age and presence of underlying medical disorders. The high-dose vaccine (1.30 outcomes per 10 000 person-weeks) was 22% (95% CI 15-29) more effective than the standard-dose vaccine (1.01 outcomes per 10 000 person-weeks) for prevention of probable influenza infections (rapid influenza test followed by oseltamivir treatment) and 22% (95% CI 16-27%) more effective for prevention of influenza hospital admissions (0.86 outcomes per 10 000 person-weeks in the high-dose cohort vs 1.10 outcomes per 10 000 person-weeks in the standard-dose cohort). Interpretation Our retrospective cohort study in US Medicare beneficiaries shows that, in people 65 years of age and older, high-dose inactivated influenza vaccine was significantly more effective than standard-dose vaccine in prevention of influenza-related medical encounters. Additionally, the large population in our study enabled us to show, for the first time, a significant reduction in influenza-related hospital admissions in high-dose compared to standard-dose vaccine recipients, an outcome not shown in randomised studies. These results provide important new information to be considered by policy makers recommending influenza vaccinations for elderly people. C1 [Izurieta, Hector S.; Lu, Yun; Pratt, Douglas; Forshee, Richard A.] US FDA, Ctr Biol Evaluat & Res, Silver Spring, MD 20993 USA. [Thadani, Nicole; Maurer, Aaron; Franks, Riley; MaCurdy, Thomas; Howery, Andrew E.] Acumen LLC, Burlingame, CA USA. [Shay, David K.; Foppa, Ivo M.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. [Foppa, Ivo M.] Battelle Mem Inst, Atlanta, GA USA. [Worrall, Chris; Kelman, Jeffrey] Ctr Medicare & Medicaid Serv, Washington, DC USA. RP Forshee, RA (reprint author), US FDA, Silver Spring, MD 20993 USA. EM richard.forshee@fda.hhs.gov OI Shay, David/0000-0001-9619-4820 FU FDA; office of the Assistant Secretary of Planning and Evaluation FX FDA and the office of the Assistant Secretary of Planning and Evaluation. NR 36 TC 31 Z9 31 U1 1 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1473-3099 EI 1474-4457 J9 LANCET INFECT DIS JI Lancet Infect. Dis. PD MAR PY 2015 VL 15 IS 3 BP 293 EP 300 DI 10.1016/S1473-3099(14)71087-4 PG 8 WC Infectious Diseases SC Infectious Diseases GA CC3SA UT WOS:000350268500027 PM 25672568 ER PT J AU Moore, MR Link-Gelles, R Schaffner, W Lynfield, R Lexau, C Bennett, NM Petit, S Zansky, SM Harrison, LH Reingold, A Miller, L Scherzinger, K Thomas, A Farley, MM Zell, ER Taylor, TH Pondo, T Rodgers, L Mcgee, L Beall, B Jorgensen, JH Whitney, CG AF Moore, Matthew R. Link-Gelles, Ruth Schaffner, William Lynfield, Ruth Lexau, Catherine Bennett, Nancy M. Petit, Susan Zansky, Shelley M. Harrison, Lee H. Reingold, Arthur Miller, Lisa Scherzinger, Karen Thomas, Ann Farley, Monica M. Zell, Elizabeth R. Taylor, Thomas H., Jr. Pondo, Tracy Rodgers, Loren McGee, Lesley Beall, Bernard Jorgensen, James H. Whitney, Cynthia G. TI Effect of use of 13-valent pneumococcal conjugate vaccine in children on invasive pneumococcal disease in children and adults in the USA: analysis of multisite, population-based surveillance SO LANCET INFECTIOUS DISEASES LA English DT Article ID IMMUNIZATION PRACTICES ACIP; IMMUNOCOMPROMISING CONDITIONS RECOMMENDATIONS; POLYSACCHARIDE VACCINE; ADVISORY-COMMITTEE; UNITED-STATES; IMPACT; SEROTYPES; COHORT AB Background In 2000, seven-valent pneumococcal conjugate vaccine (PCV7) was introduced in the USA and resulted in dramatic reductions in invasive pneumococcal disease (IPD) and moderate increases in non-PCV7 type IPD. In 2010, PCV13 replaced PCV7 in the US immunisation schedule. We aimed to assess the effect of use of PCV13 in children on IPD in children and adults in the USA. Methods We used laboratory-based and population-based data on incidence of IPD from the Active Bacterial Core surveillance (part of the Centers for Disease Control and Prevention's Emerging Infections Program) in a time-series model to compare rates of IPD before and after the introduction of PCV13. Cases of IPD between July 1, 2004, and June 30, 2013, were classified as being caused by the PCV13 serotypes against which PCV7 has no effect (PCV13 minus PCV7). In a time-series model, we used an expected outcomes approach to compare the reported incidence of IPD to that which would have been expected if PCV13 had not replaced PCV7. Findings Compared with incidence expected among children younger than 5 years if PCV7 alone had been continued, incidence of IPD overall declined by 64% (95% interval estimate [95% IE] 59-68) and IPD caused by PCV13 minus PCV7 serotypes declined by 93% (91-94), by July, 2012, to June, 2013. Among adults, incidence of IPD overall also declined by 12-32% and IPD caused by PCV13 minus PCV7 type IPD declined by 58-72%, depending on age. We estimated that over 30 000 cases of IPD and 3000 deaths were averted in the first 3 years after the introduction of PCV13. Interpretation PCV13 reduced IPD across all age groups when used routinely in children in the USA. These findings provide reassurance that, similar to PCV7, PCVs with additional serotypes can also prevent transmission to unvaccinated populations. C1 [Moore, Matthew R.; Link-Gelles, Ruth; Zell, Elizabeth R.; Taylor, Thomas H., Jr.; Pondo, Tracy; Rodgers, Loren; McGee, Lesley; Beall, Bernard; Whitney, Cynthia G.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Schaffner, William] Vanderbilt Univ, Sch Med, Dept Prevent Med, Nashville, TN 37212 USA. [Lynfield, Ruth; Lexau, Catherine] Minnesota Dept Hlth, St Paul, MN USA. [Bennett, Nancy M.] Univ Rochester, Sch Med & Dent, Dept Med, Rochester, NY 14642 USA. [Petit, Susan] Connecticut Dept Publ Hlth, Hartford, CT USA. [Zansky, Shelley M.] New York State Dept Hlth, Albany, NY USA. [Harrison, Lee H.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA. [Reingold, Arthur] Calif Emerging Infect Program, Oakland, CA USA. [Reingold, Arthur] Univ Calif Berkeley, Sch Publ Hlth, Dept Epidemiol, Berkeley, CA 94720 USA. [Miller, Lisa] Colorado Dept Publ Hlth & Environm, Denver, CO USA. [Scherzinger, Karen] Univ New Mexico, Inst Publ Hlth, Emerging Infect Program, Albuquerque, NM 87131 USA. [Thomas, Ann] Oregon Publ Hlth Div, Portland, OR USA. [Thomas, Ann] Oregon Emerging Infect Program, Portland, OR USA. [Farley, Monica M.] Emory Univ, Sch Med, Div Infect Dis, Atlanta, GA USA. [Farley, Monica M.] Atlanta VA Med Ctr, Med Specialty Care Serv Line, Infect Dis Sect, Atlanta, GA USA. [Zell, Elizabeth R.] Stat Epi Associates, Ponte Vedra Beach, FL USA. [Jorgensen, James H.] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA. RP Moore, MR (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. EM matt.moore@cdc.hhs.gov FU Centers for Disease Control and Prevention FX Centers for Disease Control and Prevention. NR 29 TC 115 Z9 116 U1 4 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1473-3099 EI 1474-4457 J9 LANCET INFECT DIS JI Lancet Infect. Dis. PD MAR PY 2015 VL 15 IS 3 BP 301 EP 309 DI 10.1016/S1473-3099(14)71081-3 PG 9 WC Infectious Diseases SC Infectious Diseases GA CC3SA UT WOS:000350268500028 PM 25656600 ER PT J AU Yen, C Hyde, TB Costa, AJ Fernandez, K Tam, JS Hugonnet, S Huvos, AM Duclos, P Dietz, VJ Burkholder, BT AF Yen, Catherine Hyde, Terri B. Costa, Alejandro J. Fernandez, Katya Tam, John S. Hugonnet, Stephane Huvos, Anne M. Duclos, Philippe Dietz, Vance J. Burkholder, Brenton T. TI The development of global vaccine stockpiles SO LANCET INFECTIOUS DISEASES LA English DT Review ID EMERGENCY RESPONSE VACCINES; NEISSERIA-MENINGITIDIS; CHILDREN; CHOLERA AB Global vaccine stockpiles, in which vaccines are reserved for use when needed for emergencies or supply shortages, have effectively provided countries with the capacity for rapid response to emergency situations, such as outbreaks of yellow fever and meningococcal meningitis. The high cost and insufficient supply of many vaccines, including oral cholera vaccine and pandemic influenza vaccine, have prompted discussion on expansion of the use of vaccine stockpiles to address a wider range of emerging and re-emerging diseases. However, the decision to establish and maintain a vaccine stockpile is complex and must take account of disease and vaccine characteristics, stockpile management, funding, and ethical concerns, such as equity. Past experience with global vaccine stockpiles provide valuable information about the processes for their establishment and maintenance In this Review we explored existing literature and stockpile data to discuss the lessons learned and to inform the development of future vaccine stockpiles. C1 [Yen, Catherine; Hyde, Terri B.; Dietz, Vance J.] Ctr Dis Control & Prevent, Global Immunizat Div, Atlanta, GA 30333 USA. [Costa, Alejandro J.; Fernandez, Katya; Hugonnet, Stephane; Huvos, Anne M.] WHO, Pandem & Epidem Dis Dept, CH-1211 Geneva, Switzerland. [Tam, John S.; Duclos, Philippe] WHO, Dept Immunizat Vaccines & Biol, CH-1211 Geneva, Switzerland. [Burkholder, Brenton T.] WHO, Bangkok, Thailand. RP Yen, C (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. EM cyen@cdc.gov FU Intramural CDC HHS [CC999999]; World Health Organization [001] NR 41 TC 5 Z9 6 U1 1 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1473-3099 EI 1474-4457 J9 LANCET INFECT DIS JI Lancet Infect. Dis. PD MAR PY 2015 VL 15 IS 3 BP 340 EP 347 DI 10.1016/S1473-3099(14)70999-5 PG 8 WC Infectious Diseases SC Infectious Diseases GA CC3SA UT WOS:000350268500032 PM 25661473 ER PT J AU Franco-Paredes, C Womack, T Bohlmeyer, T Sellers, B Hays, A Patel, K Lizarazo, J Lockhart, SR Siddiqui, W Marr, KA AF Franco-Paredes, Carlos Womack, Tanea Bohlmeyer, Teri Sellers, Brenda Hays, Allison Patel, Kalpesh Lizarazo, Jairo Lockhart, Shawn R. Siddiqui, Wajid Marr, Kieren A. TI Management of Cryptococcus gattii meningoencephalitis SO LANCET INFECTIOUS DISEASES LA English DT Article ID NEOFORMANS VAR GATTII; UNCONTROLLABLE INTRACRANIAL HYPERTENSION; ACQUIRED-IMMUNODEFICIENCY-SYNDROME; EMERGING FUNGAL PATHOGEN; PAPUA-NEW-GUINEA; CEREBROSPINAL-FLUID; PACIFIC-NORTHWEST; UNITED-STATES; AIDS PATIENTS; PATHOLOGICAL CORRELATION AB Cryptococcosis is a fungal disease caused by Cryptococcus neoformans and Cryptococcus gattii. By inhalation and subsequent pulmonary infection, it may disseminate to the CNS and cause meningitis or meningoencephalitis. Most cases occur in immunosuppressed hosts, including patients with HIV/AIDS, patients receiving immunosuppressing drugs, and solid organ transplant recipients. However, cryptococcosis also occurs in individuals with apparently healthy immune systems. A growing number of cases are caused by C gattii, with infections occurring in both immunosuppressed and immunocompetent individuals. In the majority of documented cases, treatment of C gattii infection of the CNS requires aggressive management of raised intracranial pressure along with standard antifungal therapy. Early cerebrospinal fluid evacuation is often needed through placement of a percutaneous lumbar drain or ventriculostomy. Furthermore, pharmacological immunosuppression with a high dose of dexamethasone is sometimes needed to ameliorate a persistently increased inflammatory response and to reduce intracranial pressure. In this Grand Round, we present the case of an otherwise healthy adolescent female patient, who, despite aggressive management, succumbed to C gattii meningoencephalitis. We also present a review of the existing literature and discuss optimum clinical management of meningoencephalitis caused by C gattii. C1 [Franco-Paredes, Carlos; Womack, Tanea; Bohlmeyer, Teri; Sellers, Brenda; Hays, Allison; Siddiqui, Wajid] Phoebe Putney Mem Hosp, Albany, GA 31701 USA. [Franco-Paredes, Carlos] Hosp Infantil Mexico Dr Federico Gomez, Mexico City, DF, Mexico. [Patel, Kalpesh] Albany Neurol, Albany, GA USA. [Lizarazo, Jairo] Hosp Univ Erasmo Meoz, Cucuta, Norte De Santan, Colombia. [Lockhart, Shawn R.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Marr, Kieren A.] Johns Hopkins Univ, Med Ctr, Baltimore, MD 21218 USA. [Marr, Kieren A.] Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA. RP Franco-Paredes, C (reprint author), Phoebe Putney Mem Hosp, Infect Dis Clin, Albany, GA 31701 USA. EM carlos.franco.paredes@gmail.com FU [K24 AI085118]; [U01 AI109657] FX KAM was supported in part by K24 AI085118 and U01 AI109657. The findings and conclusions of this article are those of the authors and do not necessarily represent the views of the US Centers for Disease Control and Prevention. NR 73 TC 20 Z9 21 U1 0 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1473-3099 EI 1474-4457 J9 LANCET INFECT DIS JI Lancet Infect. Dis. PD MAR PY 2015 VL 15 IS 3 BP 348 EP 355 DI 10.1016/S1473-3099(14)70945-4 PG 8 WC Infectious Diseases SC Infectious Diseases GA CC3SA UT WOS:000350268500033 PM 25467646 ER PT J AU Agborsangaya, CB Majumdar, SR Sharma, AM Gregg, EW Padwal, RS AF Agborsangaya, Calypse B. Majumdar, Sumit R. Sharma, Arya M. Gregg, Edward W. Padwal, Raj S. TI Multimorbidity in a Prospective Cohort: Prevalence and Associations with Weight Loss and Health Status in Severely Obese Patients SO OBESITY LA English DT Article ID QUALITY-OF-LIFE; BARIATRIC SURGERY; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; DIABETIC-PATIENTS; UNITED-STATES; OUTCOMES; METAANALYSIS; INDIVIDUALS; REMISSION AB ObjectiveTo examine the prevalence of multimorbidity (2 chronic conditions) in severely obese patients and its associations with weight loss and health status over 2 years. MethodsIn a prospective cohort including 500 severely obese adults, self-reported prevalence of 20 chronic conditions was calculated at baseline and 2 years. Multivariable logistic regression models were fitted to test the covariate-adjusted associations between 5% weight reduction and reduction in multimorbidity and the association between health status (visual analogue scale [VAS]) and reduction in multimorbidity over 2 years. ResultsAfter 2 years, mean weight change was -12.9 18.7 kg, 53% had 5% weight reduction, mean change in VAS was 11.5 +/- 21.2, and 53.5% had 10% increase in VAS. Multimorbidity was reported in 95.4% and 92.8% patients at baseline and 2 years, respectively. Weight loss (5%) over 2 years was associated with reduction in multimorbidity (adjusted OR = 1.7, 95% CI 1.1-2.7). Reduction in multimorbidity was associated with clinically important improvements (10% increase in VAS) in health status (adjusted OR=2.5, 95% CI 1.6, 4.0). ConclusionsMultimorbidity is common in severely obese patients. Having 5% weight reduction over 2 years was associated with a reduction in multimorbidity, which was also associated with improvements in health status. C1 [Agborsangaya, Calypse B.; Majumdar, Sumit R.; Sharma, Arya M.; Padwal, Raj S.] Univ Alberta, Dept Med & Dent, Edmonton, AB, Canada. [Agborsangaya, Calypse B.; Majumdar, Sumit R.; Sharma, Arya M.; Padwal, Raj S.] Alberta Diabet Inst, Edmonton, AB, Canada. [Gregg, Edward W.] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA USA. RP Agborsangaya, CB (reprint author), Univ Alberta, Dept Med & Dent, Edmonton, AB, Canada. EM agborsan@ualberta.ca NR 34 TC 5 Z9 5 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1930-7381 EI 1930-739X J9 OBESITY JI Obesity PD MAR PY 2015 VL 23 IS 3 BP 707 EP 712 DI 10.1002/oby.21008 PG 6 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA CC3LG UT WOS:000350249700029 PM 25682926 ER PT J AU Woods, CM Applebaum, B Green, Y Kallgren, DL Kappeler, E AF Woods, Caira M. Applebaum, Bethany Green, Yvonne Kallgren, Deborah L. Kappeler, Evelyn CA US Dept Hlth Human Serv TI Women's Health: 30 Years of Progress in the US Department of Health and Human Services SO PUBLIC HEALTH REPORTS LA English DT Editorial Material C1 [Woods, Caira M.] US Dept HHS, Off Womens Hlth, Washington, DC 20201 USA. [Applebaum, Bethany] US Dept HHS, Hlth Resources & Serv Adm, Off Womens Hlth, Rockville, MD USA. [Green, Yvonne] Ctr Dis Control & Prevent, US Dept HHS, Off Womens Hlth, Atlanta, GA USA. [Kallgren, Deborah L.] US Dept HHS, US FDA, Off Womens Hlth, Silver Spring, MD USA. [Kappeler, Evelyn] US Dept HHS, Off Adolescent Hlth, Rockville, MD USA. RP Woods, CM (reprint author), US Dept HHS, Off Womens Hlth, 200 Independence Ave SW, Washington, DC 20201 USA. EM caira.woods@hhs.gov NR 54 TC 1 Z9 1 U1 0 U2 0 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD MAR-APR PY 2015 VL 130 IS 2 BP 123 EP 127 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CC7FR UT WOS:000350533600004 PM 25729100 ER PT J AU Santibanez, S Siegel, V O'Sullivan, M Lacson, R Jorstad, C AF Santibanez, Scott Siegel, Vivi O'Sullivan, Megan Lacson, Romel Jorstad, Connie TI Health Communications and Community Mobilization During an Ebola Response: Partnerships with Community and Faith-Based Organizations SO PUBLIC HEALTH REPORTS LA English DT Editorial Material C1 [Santibanez, Scott; Siegel, Vivi; O'Sullivan, Megan; Lacson, Romel] Ctr Dis Control & Prevent, Joint Informat Ctr Outreach Team, CDC Ebola Response, Atlanta, GA 30333 USA. [Jorstad, Connie] Assoc State & Terr Hlth Officials, Arlington, VA USA. RP Santibanez, S (reprint author), Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Dis, Div Preparedness & Emerging Infect, 1600 Clifton Rd NE,MS-C18, Atlanta, GA 30333 USA. EM zqg5@cdc.gov NR 17 TC 2 Z9 2 U1 0 U2 6 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD MAR-APR PY 2015 VL 130 IS 2 BP 128 EP 133 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CC7FR UT WOS:000350533600005 PM 25729101 ER PT J AU Schubauer-Berigan, MK Anderson, JL Hein, MJ Little, MP Sigurdson, AJ Pinkerton, LE AF Schubauer-Berigan, Mary K. Anderson, Jeri L. Hein, Misty J. Little, Mark P. Sigurdson, Alice J. Pinkerton, Lynne E. TI Breast Cancer Incidence in a Cohort of US Flight Attendants SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE LA English DT Article DE flight crew; ionizing radiation; cosmic; circadian rhythm disruption; cohort studies ID CIRCADIAN-RHYTHM DISRUPTION; COSMIC-RADIATION EXPOSURE; AIRLINE CABIN CREW; REPRODUCTIVE FACTORS; QUALITY FACTOR; NIGHT WORK; RISK; MORTALITY; COUNTRIES; ALTITUDES AB BackgroundFlight attendants may have elevated breast cancer incidence (BCI). We evaluated BCI's association with cosmic radiation dose and circadian rhythm disruption among 6,093 female former U.S. flight attendants. MethodsWe collected questionnaire data on BCI and risk factors for breast cancer from 2002-2005. We conducted analyses to evaluate (i) BCI in the cohort compared to the U.S. population; and (ii) exposure-response relations. We applied an indirect adjustment to estimate whether parity and age at first birth (AFB) differences between the cohort and U.S. population could explain BCI that differed from expectation. ResultsBCI was elevated but may be explained by lower parity and older AFB in the cohort than among U.S. women. BCI was not associated with exposure metrics in the cohort overall. Significant positive associations with both were observed only among women with parity of three or more. ConclusionsFuture cohort analyses may be informative on the role of these occupational exposures and non-occupational risk factors. Am. J. Ind. Med. 58:252-266, 2015. (c) 2015 Wiley Periodicals, Inc. C1 [Schubauer-Berigan, Mary K.; Anderson, Jeri L.; Hein, Misty J.; Pinkerton, Lynne E.] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Industrywide Studies Branch, Cincinnati, OH 45226 USA. [Little, Mark P.; Sigurdson, Alice J.] NCI, Div Canc Epidemiol & Genet, Radiat Epidemiol Branch, Bethesda, MD 20892 USA. RP Schubauer-Berigan, MK (reprint author), NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Industrywide Studies Branch, Cincinnati, OH 45226 USA. EM zcg3@cdc.gov OI Little, Mark/0000-0003-0980-7567 FU National Cancer Institute; Office of Women's Health of the U.S. Department of Health and Human Services FX The authors thank many able colleagues currently or formerly employed at NIOSH, including Steven Allee, Faith Armstrong, Christine Gersic, Stacy Kramer, Zachary Zivkovich, and others, for their assistance in collecting, coding, cleaning, and programming of data for the study. We thank researchers at Battelle and Westat for assistance with the administration of the questionnaire and medical record follow-back and coding. Martha Waters, Robert Daniels, and Elizabeth Whelan of NIOSH and Elaine Ron (deceased) of NCI provided input into the dosimetry, design, or interpretation of the study. We thank Lian Luo and James Yiin for creating the SEER-based breast cancer incidence rate file. The study was funded, in part, by an interagency agreement with the National Cancer Institute and the Office of Women's Health of the U.S. Department of Health and Human Services. NR 41 TC 5 Z9 6 U1 2 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0271-3586 EI 1097-0274 J9 AM J IND MED JI Am. J. Ind. Med. PD MAR PY 2015 VL 58 IS 3 BP 252 EP 266 DI 10.1002/ajim.22419 PG 15 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CC0ZN UT WOS:000350068700002 PM 25678455 ER PT J AU Reichard, AA Konda, S Jackson, LL AF Reichard, Audrey A. Konda, Srinivas Jackson, Larry L. TI Occupational Burns Treated in Emergency Departments SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE LA English DT Article DE burns; occupational injuries; nonfatal; food service injuries; construction injuries ID WORK-RELATED BURNS; CONSTRUCTION WORKERS; COMPENSATION CLAIMS; ELECTRICAL INJURY; WASHINGTON-STATE; EPIDEMIOLOGY; SURVEILLANCE; EXPERIENCE; OREGON; SYSTEM AB BackgroundDespite reported declines, occupational burn injuries remain a workplace safety concern. More severe burns may result in costly medical treatment and long-term physical and psychological consequences. MethodsWe used the National Electronic Injury Surveillance SystemOccupational Supplement to produce national estimates of burns treated in emergency departments (EDs). We analyzed data trends from 1999 to 2008 and provided detailed descriptions of 2008 data. ResultsFrom 1999 to 2008 there were 1,132,000 (95% CI: 192,300) nonfatal occupational burns treated in EDs. Burn numbers and rates declined approximately 40% over the 10 years. In 2008, men and younger workers 15-24 years old had the highest rates. Scalds and thermal burns accounted for more than 60% of burns. Accommodation and food service, manufacturing, and construction industries had the largest number of burns. ConclusionsDespite declining burn rates, emphasis is needed on reducing burn hazards to young food service workers and using job specific hazard analyses to prevent burns. Am. J. Ind. Med. 58:290-298, 2015. (c) 2015 Wiley Periodicals, Inc. C1 [Reichard, Audrey A.; Konda, Srinivas; Jackson, Larry L.] NIOSH, Div Safety Res, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. RP Reichard, AA (reprint author), NIOSH, Div Safety Res, 1095 Willowdale Rd MS 1808, Morgantown, WV 26505 USA. EM AReichard@cdc.gov RI Konda, Srinivas/G-2747-2015 OI Konda, Srinivas/0000-0002-8934-4111 FU U.S. Government FX All authors are federal government employees and preparation of this manuscript was completely funded by the U.S. Government. We thank Tom Schroeder and other members of the CPSC Division of Hazards and Data Systems for their management of NEISS and collaboration with NIOSH in the collection of work-related injuries and illnesses, as well as the coders at each NEISS hospital for their diligent medical record abstraction. We thank Susan Derk, Tracina Jackson, and other NIOSH staff for their efforts in collecting, coding, editing, and analyzing NEISS-Work data. NR 45 TC 2 Z9 2 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0271-3586 EI 1097-0274 J9 AM J IND MED JI Am. J. Ind. Med. PD MAR PY 2015 VL 58 IS 3 BP 290 EP 298 DI 10.1002/ajim.22407 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CC0ZN UT WOS:000350068700006 PM 25678457 ER PT J AU Caspersen, CJ Thomas, GD Beckles, GLA Bullard, KM AF Caspersen, Carl J. Thomas, G. Darlene Beckles, Gloria L. A. Bullard, Kai McKeever TI Secular Changes in Prediabetes Indicators Among Older-Adult Americans, 1999-2010 SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID FASTING PLASMA-GLUCOSE; DIABETES-MELLITUS; MEDICAL-EDUCATION; HEMOGLOBIN A(1C); UNITED-STATES; WEIGHT-LOSS; FOLLOW-UP; PREVALENCE; US; COMPLICATIONS AB Background: Sex-specific prediabetes estimates are not available for older-adult Americans. Purpose: To estimate prediabetes prevalence, using nationally representative data, in civilian, non-institutionalized, older U.S. adults. Methods: Data from 7,995 participants aged >= 50 years from the 1999-2010 National Health and Nutrition Examination Surveys were analyzed in 2013. Prediabetes was defined as hemoglobin Alc=5.7%-6.4% (39-47 mmol/mol [HbAlc5.7]), fasting plasma glucose of 100-125 mg/dL (impaired fasting glucose [IFG]), or both. Crude and age-adjusted prevalences for prediabetes, HbAlc5.7, and IFG by sex and three age groups were calculated, with additional adjustment for sex, age, race/ethnicity, poverty status, education, living alone, and BMI. Results: From 1999 to 2005 and 2006 to 2010, prediabetes increased for adults aged 50-64 years (38.5% [95% CI=35.3, 41.8] to 45.9% [42.3, 49.5], p=0.003) and 65-74 years (41.3% [37.2, 45.5] to 47.9% [44.5, 51.3]; p=0.016), but not significantly for adults aged 75 years (45.1% [95% CI=41.1, 49.1] to 48.9% [95% CI=45.2, 52.6]; p>0.05). Prediabetes increased significantly for women in the two youngest age groups, and HbAlc5.7 for both sexes (except men aged 75 years), but IFG remained stable for both sexes. Men had higher prevalences than women for prediabetes and IFG among adults aged 50-64 years, and for IFG among adults aged >= 75 years. Across demographic subgroups, adjusted prevalence gains for both sexes were similar and most pronounced for HbAlc5.7, virtually absent for IFG, but greater for women than men for prediabetes. Conclusions: Given the large, growing prediabetes prevalence and its anticipated burden, older adults, especially women, are likely intervention targets. Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine C1 [Caspersen, Carl J.; Thomas, G. Darlene; Beckles, Gloria L. A.; Bullard, Kai McKeever] CDC, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Diabet Translat, Atlanta, GA 30341 USA. RP Caspersen, CJ (reprint author), CDC, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Diabet Translat, Epidemiol & Stat Branch, Mailstop K-10,4770 Buford Highway NE, Atlanta, GA 30341 USA. EM cjcl@cdc.gov FU Intramural CDC HHS [CC999999] NR 41 TC 1 Z9 1 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD MAR PY 2015 VL 48 IS 3 BP 253 EP 263 DI 10.1016/j.amepre.2014.10.004 PG 11 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA CB6LZ UT WOS:000349739800002 PM 25601724 ER PT J AU Xu, X Alexander, RL Simpson, SA Goates, S Nonnemaker, JM Davis, KC McAfee, T AF Xu, Xin Alexander, Robert L. Simpson, Sean A. Goates, Scott Nonnemaker, James M. Davis, Kevin C. McAfee, Tim TI A Cost-Effectiveness Analysis of the First Federally Funded Antismoking Campaign SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID ENVIRONMENTAL TOBACCO-SMOKE; MASS-MEDIA CAMPAIGNS; UNITED-STATES; CESSATION; ADULTS; INTERVENTIONS; EXPOSURE; REVIEWS AB Background: In 2012, CDC launched the first federally funded national mass media antismoking campaign. The Tips From Former Smokers (Tips) campaign resulted in a 12% relative increase in population-level quit attempts. Purpose: Cost-effectiveness analysis was conducted in 2013 to evaluate Tips from a funding agency's perspective. Methods: Estimates of sustained cessations; premature deaths averted; undiscounted life years (LYs) saved; and quality-adjusted life years (QALYs) gained by Tips were estimated. Results: Tips saved about 179,099 QALYs and prevented 17,109 premature deaths in the U.S. With the campaign cost of roughly $48 million, Tips spent approximately $480 per quitter, $2,819 per premature death averted, $393 per LY saved, and $268 per QALY gained. Conclusions: Tips was not only successful at reducing smoking-attributable morbidity and mortality but also was a highly cost-effective mass media intervention. Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine C1 [Goates, Scott] CDC, Off Associate Director Policy, Off Director, Atlanta, GA 30341 USA. [Simpson, Sean A.; Nonnemaker, James M.; Davis, Kevin C.] RTI Int, Res Triangle Pk, NC USA. RP Xu, X (reprint author), CDC, Off Smoking & Hlth, 4770 Buford Hwy,MS-F79, Atlanta, GA 30341 USA. EM iip5@cdc.gov FU CDC, USDHHS FX None of the authors have conflicts of interest. Survey and part of the analysis was supported by CDC, USDHHS. The findings and conclusions in this report are those of the authors and do not necessarily represent the official positions of CDC or RTI International. NR 34 TC 13 Z9 13 U1 1 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD MAR PY 2015 VL 48 IS 3 BP 318 EP 325 DI 10.1016/j.amepre.2014.10.011 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA CB6LZ UT WOS:000349739800009 PM 25498550 ER PT J AU Xu, X Bishop, EE Kennedy, SM Simpson, SA Pechacek, TF AF Xu, Xin Bishop, Ellen E. Kennedy, Sara M. Simpson, Sean A. Pechacek, Terry F. TI Annual Healthcare Spending Attributable to Cigarette Smoking An Update SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID EXPENDITURE PANEL SURVEY; UNITED-STATES; COSTS; CESSATION; ACCURACY; DEATHS AB Background: Fifty years after the first Surgeon General's report, tobacco use remains the nation's leading preventable cause of death and disease, despite declines in adult cigarette smoking prevalence. Smoking-attributable healthcare spending is an important part of overall smoking-attributable costs in the U.S. Purpose: To update annual smoking-attributable healthcare spending in the U.S. and provide smoking-attributable healthcare spending estimates by payer (e.g., Medicare, Medicaid, private insurance) or type of medical services. Methods: Analyses used data from the 2006-2010 Medical Expenditure Panel Survey linked to the 2004-2009 National Health Interview Survey. Estimates from two-part models were combined to predict the share of annual healthcare spending that could be attributable to cigarette smoking. The analysis was conducted in 2013. Results: By 2010, 8.7% (95% CI=6.8%, 11.2%) of annual healthcare spending in the U.S. could be attributed to cigarette smoking, amounting to as much as $170 billion per year. More than 60% of the attributable spending was paid by public programs, including Medicare, other federally sponsored programs, or Medicaid. Conclusions: These findings indicate that comprehensive tobacco control programs and policies are still needed to continue progress toward ending the tobacco epidemic in the U.S. 50 years after the release of the first Surgeon General's report on smoking and health. Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine C1 [Xu, Xin; Pechacek, Terry F.] CDC, Off Smoking & Hlth, Atlanta, GA 30341 USA. CDC, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Bishop, Ellen E.; Kennedy, Sara M.; Simpson, Sean A.] RTI Int, Dept Biostat & Epidemiol, Res Triangle Pk, NC USA. RP Xu, X (reprint author), CDC, Off Smoking & Hlth, 4770 Buford Hwy MS-F79, Atlanta, GA 30341 USA. EM xirum@cdc.gov FU CDC, USDHHS FX The authors acknowledge the contribution of Justin Trogdon and Charles Feagan, who assisted with data analysis. The analysis was supported in part by the CDC, USDHHS. The findings and conclusions in this report are those of authors and do not necessarily represent the official positions of CDC or RTI International. NR 36 TC 35 Z9 35 U1 3 U2 9 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD MAR PY 2015 VL 48 IS 3 BP 326 EP 333 DI 10.1016/j.amepre.2014.10.012 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA CB6LZ UT WOS:000349739800010 PM 25498551 ER PT J AU Gilbert, LK Breiding, MJ Merrick, MT Thompson, WW Ford, DC Dhingra, SS Parks, SE AF Gilbert, Leah K. Breiding, Matthew J. Merrick, Melissa T. Thompson, William W. Ford, Derek C. Dhingra, Satvinder S. Parks, Sharyn E. TI Childhood Adversity and Adult Chronic Disease An Update from Ten States and the District of Columbia, 2010 SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID EXPERIENCES; MORTALITY; HEALTH AB Background: Adverse childhood experiences (ACEs), including child abuse and family dysfunction, are linked to leading causes of adult morbidity and mortality. Most prior ACE studies were based on a nonrepresentative patient sample from one Southern California HMO. Purpose: To determine if ACE exposure increases the risk of chronic disease and disability using a larger, more representative sample of adults than prior studies. Methods: Ten states and the District of Columbia included an optional ACE module in the 2010 Behavioral Risk Factor Surveillance Survey, a national cross-sectional, random-digit-dial telephone survey of adults. Analysis was conducted in November 2012. Respondents were asked about nine ACEs, including physical, sexual, and emotional abuse and household member mental illness, alcoholism, drug abuse, imprisonment, divorce, and intimate partner violence. An ACE score was calculated for each subject by summing the endorsed ACE items. After controlling for sociodemographic variables, weighted AORs were calculated for self-reported health conditions given exposure to zero, one to three, four to six, or seven to nine ACEs. Results: Compared to those who reported no ACE exposure, the adjusted odds of reporting myocardial infarction, asthma, fair/poor health, frequent mental distress, and disability were higher for those reporting one to three, four to six, or seven to nine ACEs. Odds of reporting coronary heart disease and stroke were higher for those who reported four to six and seven to nine ACEs; odds of diabetes were higher for those reporting one to three and four to six ACEs. Conclusions: These findings underscore the importance of child maltreatment prevention as a means to mitigate adult morbidity and mortality. Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine C1 [Gilbert, Leah K.; Merrick, Melissa T.; Ford, Derek C.] CDC, Natl Ctr Injury Prevent & Control, Div Violence Prevent, Atlanta, GA 30341 USA. [Breiding, Matthew J.] CDC, Natl Ctr Injury Prevent & Control, Div Unintent Injury Prevent, Atlanta, GA 30341 USA. [Thompson, William W.] CDC, Natl Ctr Birth Defects & Dev Disabil, Div Birth Defects & Dev Disabil, Atlanta, GA 30341 USA. [Dhingra, Satvinder S.] CDC, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Populat Hlth, Atlanta, GA 30341 USA. [Parks, Sharyn E.] CDC, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, Atlanta, GA 30341 USA. RP Gilbert, LK (reprint author), CDC, Natl Ctr Injury Prevent & Control, Div Violence Prevent, 4770 Buford Highway,NE,MS F-64, Atlanta, GA 30341 USA. EM LGilbert@cdc.gov NR 9 TC 23 Z9 23 U1 1 U2 27 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD MAR PY 2015 VL 48 IS 3 BP 345 EP 349 DI 10.1016/j.amepre.2014.09.006 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA CB6LZ UT WOS:000349739800013 PM 25300735 ER PT J AU Joyce, MP Kuhar, D Brooks, JT AF Joyce, M. Patricia Kuhar, David Brooks, John T. TI Notes From the Field: Occupationally Acquired HIV Infection Among Health Care Workers-United States, 1985-2013 SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Editorial Material C1 [Joyce, M. Patricia; Brooks, John T.] CDC, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Kuhar, David] CDC, Div Healthcare Qual Promot, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. RP Joyce, MP (reprint author), CDC, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. EM pjoyce@cdc.gov NR 3 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1600-6135 EI 1600-6143 J9 AM J TRANSPLANT JI Am. J. Transplant. PD MAR PY 2015 VL 15 IS 3 BP 841 EP 842 DI 10.1111/ajt.13250 PG 2 WC Surgery; Transplantation SC Surgery; Transplantation GA CB9UD UT WOS:000349977700036 ER PT J AU Anderson, RT Morris, CR Kimmick, G Trentham-Dietz, A Camacho, F Wu, XC Sabatino, SA Fleming, ST Lipscomb, J AF Anderson, Roger T. Morris, Cyllene R. Kimmick, Gretchen Trentham-Dietz, Amy Camacho, Fabian Wu, Xiao-Cheng Sabatino, Susan A. Fleming, Steven T. Lipscomb, Joseph TI Patterns of Locoregional Treatment for Nonmetastatic Breast Cancer by Patient and Health System Factors SO CANCER LA English DT Article DE breast cancer; breast-conserving surgery (BCS); cancer registry; nonmetastatic; disparity ID CONSERVING SURGERY; MEDICARE BENEFICIARIES; SOCIOECONOMIC-STATUS; RADIATION-THERAPY; MASTECTOMY RATES; UNITED-STATES; POPULATION; CARCINOMA; TRENDS; WOMEN AB BACKGROUNDThe purpose of this study was to examine local definitive therapy for nonmetastatic breast cancer with the Patterns of Care Breast and Prostate Cancer (POCBP) study of the National Program of Cancer Registries (Centers for Disease Control and Prevention). METHODSPOCBP medical record data were re-abstracted in 7 state/regional registry systems (Georgia, North Carolina, Kentucky, Louisiana, Wisconsin, Minnesota, and California) to verify data quality and assess treatment patterns in the population. National Comprehensive Cancer Network clinical practice treatment guidelines were aligned with American Joint Committee on Cancer staging at diagnosis to appraise care. RESULTSSix thousand five hundred five of 9142 patients with registry-confirmed breast cancer were coded as having primary disease with stage 0 to IIIA tumors and were included in the study. Approximately 88% received guideline-concordant locoregional treatment. However, this outcome varied by age group: 92% of women < age 50 versus 80% of women age 70 years old received guideline care (P<0.01). Characteristics that best discriminated receipt (no/yes) of guideline-concordant care in receiver operating curve analyses were the receipt of breast-conserving surgery (BCS) versus mastectomy (C=0.70), patient age (C=0.62), a greater tumor stage (C=0.60), public insurance (C=0.58), and the presence of at least mild comorbidity (C=0.55). Radiation therapy (RT) after BCS was the most omitted treatment component causing nonconcordance in the study population. In multivariate regression, the effects of the treatment facility, ductal carcinoma in situ, race, and comorbidity on nonconcordant care differed by age group. CONCLUSIONSPatterns of underuse of standard therapies for breast cancer vary by age group and BCS use, with which there is a risk of omission of RT. Cancer 2015;121:790-799. (c) 2014 American Cancer Society. In a large national database, the likelihood of receiving guideline-concordant care among patients with nonmetastatic breast cancer is lower with older age and with public insurance versus private insurance. Radiation therapy is the most omitted treatment component. Patient navigation targeted at high-risk or vulnerable patients may be needed to ensure access to high-quality care. C1 [Anderson, Roger T.] Univ Virginia, Sch Med, Charlottesville, VA 22901 USA. [Morris, Cyllene R.] Univ Calif Davis Hlth Syst, Inst Populat Hlth Improvement, Calif Canc Reporting & Epidemiol Surveillance Pro, Sacramento, CA USA. [Kimmick, Gretchen] Duke Univ, Med Ctr, Multidisciplinary Breast Program, Durham, NC USA. [Trentham-Dietz, Amy] Univ Wisconsin, Carbone Canc Ctr, Madison, WI USA. [Camacho, Fabian] Penn State Coll Med, Hershey, PA USA. [Wu, Xiao-Cheng] Louisiana State Univ, Hlth Sci Ctr, Sch Publ Hlth, Program Epidemiol, New Orleans, LA USA. [Sabatino, Susan A.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA USA. [Fleming, Steven T.] Univ Kentucky, Coll Publ Hlth, Dept Epidemiol, Lexington, KY USA. [Lipscomb, Joseph] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Lipscomb, Joseph] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA. RP Anderson, RT (reprint author), Univ Virginia, Sch Med, Hosp West RM 6203E Jefferson Pk Ave, Charlottesville, VA 22901 USA. EM rtanders@virginia.edu FU Centers for Disease Control and Prevention through California Cancer Registry (Public Health Institute) [1-U01-DP000260]; Centers for Disease Control and Prevention through Emory University [1-U01-DP000258]; Centers for Disease Control and Prevention through Louisiana State University Health Sciences Center [1-U01-DP000253]; Centers for Disease Control and Prevention through Minnesota Cancer Surveillance System (Minnesota Department of Health) [1-U01-DP000259]; Centers for Disease Control and Prevention through Medical College of Wisconsin [1-U01-DP000261]; Centers for Disease Control and Prevention through University of Kentucky [1-U01-DP000251]; Centers for Disease Control and Prevention through Wake Forest University [1-U01-DP000264] FX The Breast and Prostate Cancer Data Quality and Patterns of Care Study was supported by the Centers for Disease Control and Prevention through cooperative agreements with the California Cancer Registry (Public Health Institute; 1-U01-DP000260), Emory University (1-U01-DP000258), the Louisiana State University Health Sciences Center (1-U01-DP000253), the Minnesota Cancer Surveillance System (Minnesota Department of Health; 1-U01-DP000259), the Medical College of Wisconsin (1-U01-DP000261), the University of Kentucky (1-U01-DP000251), and Wake Forest University (1-U01-DP000264). NR 41 TC 3 Z9 3 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0008-543X EI 1097-0142 J9 CANCER-AM CANCER SOC JI Cancer PD MAR 1 PY 2015 VL 121 IS 5 BP 790 EP 799 DI 10.1002/cncr.29092 PG 10 WC Oncology SC Oncology GA CB9WY UT WOS:000349986100020 PM 25369150 ER PT J AU Otieno, FO Ndivo, R Oswago, S Pals, S Chen, R Thomas, T Kunneke, E Mills, LA McLellan-Lemal, E AF Otieno, Fredrick Odhiambo Ndivo, Richard Oswago, Simon Pals, Sherri Chen, Robert Thomas, Timothy Kunneke, Ernesta Mills, Lisa A. McLellan-Lemal, Eleanor TI Correlates of prevalent sexually transmitted infections among participants screened for an HIV incidence cohort study in Kisumu, Kenya SO INTERNATIONAL JOURNAL OF STD & AIDS LA English DT Article DE Kenya; sexually transmitted infection; prevalence; correlates; Kisumu ID SIMPLEX-VIRUS TYPE-2; IMPROVED TREATMENT SERVICES; FEMALE SEX WORKERS; RISK-FACTORS; HOMOSEXUAL-MEN; DRUG-USE; RURAL TANZANIA; HEALTH-RISKS; BEHAVIOR; WOMEN AB We determined the prevalence of four sexually transmitted infections and the demographic and behavioural correlates associated with having one or more sexually transmitted infections among participants in an HIV incidence cohort study in Kisumu, western Kenya. Participants were enrolled from a convenience sample and underwent aetiologic sexually transmitted infection investigation. Demographic and behavioural information were collected and basic clinical evaluation performed. Multiple regression analysis was done to determine variables associated with having one or more sexually transmitted infections. We screened 846, 18- to 34-year-olds. One-third had at least one sexually transmitted infection with specific prevalence being: syphilis, 1.6%; gonorrhoea, 2.4%; herpes simplex virus type-2, 29.1%; chlamydia, 2.8%; and HIV, 14.8%. Odds of having any sexually transmitted infection were higher among participants who were women, were aged 20-24 or 30-34 years compared to 18-19 years, had secondary or lower education compared to tertiary education, were divorced, widowed or separated compared to singles, reported having unprotected sex compared to those who did not, reported previous sexually transmitted infection treatment, and tested HIV-positive. Multiple strategies are needed to address the overall high prevalence of sexually transmitted infections as well as the gender disparity found in this Kenyan population. Structural interventions may be beneficial in addressing educational and socio-economic barriers, and increasing the uptake of health-promoting practices. C1 [Otieno, Fredrick Odhiambo; Ndivo, Richard; Oswago, Simon] Kenya Med Res Inst KEMRI, CDC Program, Ctr Global Hlth Res, Kisumu, Kenya. [Pals, Sherri; Chen, Robert; Thomas, Timothy; Mills, Lisa A.; McLellan-Lemal, Eleanor] Ctr Dis Control & Prevent, Off Infect Dis, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div HIV AIDS Prevent, Atlanta, GA USA. [Kunneke, Ernesta] Univ Western Cape, Sch Publ Hlth, Fac Community & Hlth Sci, Cape Town, South Africa. RP Otieno, FO (reprint author), KEMRI CDC Res & Publ Hlth Collaborat, Off Kisumu Busia Rd,POB 1578-40100, Kisumu, Kenya. EM FOtieno@kemricdc.org FU U.S. Centers for Disease Control and Prevention FX The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The study was funded through a cooperative agreement by the U.S. Centers for Disease Control and Prevention. NR 70 TC 1 Z9 1 U1 3 U2 10 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0956-4624 EI 1758-1052 J9 INT J STD AIDS JI Int. J. STD AIDS PD MAR PY 2015 VL 26 IS 4 BP 225 EP 237 DI 10.1177/0956462414532447 PG 13 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CB9YR UT WOS:000349991300002 PM 24810218 ER PT J AU Zhang, ZF Gillespie, C Welsh, JA Hu, FB Yang, QH AF Zhang, Zefeng Gillespie, Cathleen Welsh, Jean A. Hu, Frank B. Yang, Quanhe TI Usual Intake of Added Sugars and Lipid Profiles Among the US Adolescents: National Health and Nutrition Examination Survey, 2005-2010 SO JOURNAL OF ADOLESCENT HEALTH LA English DT Article DE Usual percentage of calories; Added sugars; Lipid profiles; Dyslipidemia ID EPISODICALLY CONSUMED FOODS; MEASUREMENT ERROR; LIPOPROTEIN CHOLESTEROL; CARDIOVASCULAR-DISEASE; NUTRIENT INTAKE; YOUNG MEN; FRUCTOSE; CHILDREN; ATHEROSCLEROSIS; CONSUMPTION AB Purpose: Although studies suggest that higher consumption of added sugars is associated with cardiovascular risk factors in adolescents, none have adjusted for measurement errors or examined its association with the risk of dyslipidemia. Methods: We analyzed data of 4,047 adolescents aged 12-19 years from the 2005-2010 National Health and Nutrition Examination Survey, a nationally representative, cross-sectional survey. We estimated the usual percentage of calories (%kcal) from added sugars using up to two 24-hour dietary recalls and the National Cancer Institute method to account for measurement error. Results: The average usual % kcal from added sugars was 16.0%. Most adolescents (88.0%) had usual intake of >= 10% of total energy, and 5.5% had usual intake of >= 25% of total energy. After adjustment for potential confounders, usual % kcal from added sugars was inversely associated with high-density lipoprotein (HDL) and positively associated with triglycerides (TGs), TG-to-HDL ratio, and total cholesterol (TC) to HDL ratio. Comparing the lowest and highest quintiles of intake, HDLs were 49.5 (95% confidence interval [CI], 47.4-51.6) and 46.4 mg/dL (95% CI, 45.2-47.6; p = .009), TGs were 85.6 (95% CI, 75.5-95.6) and 101.2 mg/dL (95% CI, 88.7-113.8; p = .037), TG to HDL ratios were 2.28 (95% CI, 1.84-2.70) and 2.73 (95% CI, 2.11-3.32; p =.017), and TC to HDL ratios were 3.41 (95% CI, 3.03-3.79) and 3.70 (95% CI, 3.24-4.15; p = .028), respectively. Comparing the highest and lowest quintiles of intake, adjusted odds ratio of dyslipidemia was 1.41 (95% CI, 1.01-1.95). The patterns were consistent across sex, race/ethnicity, and body mass index subgroups. No association was found for TC, low-density lipoprotein, and non-HDL cholesterol. Conclusions: Most U.S. adolescents consumed more added sugars than recommended for heart health. Usual intake of added sugars was significantly associated with several measures of lipid profiles. Published by Elsevier Inc. on behalf of Society for Adolescent Health and Medicine. C1 [Zhang, Zefeng; Gillespie, Cathleen; Yang, Quanhe] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA 30341 USA. [Welsh, Jean A.] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA. [Welsh, Jean A.] Childrens Healthcare Atlanta, Wellness Dept, Atlanta, GA USA. [Hu, Frank B.] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. [Hu, Frank B.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. RP Zhang, ZF (reprint author), Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Mailstop F-72,4770 Buford Highway NE, Atlanta, GA 30341 USA. EM zzhang3@cdc.gov FU Intramural CDC HHS [CC999999] NR 34 TC 2 Z9 2 U1 1 U2 14 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X EI 1879-1972 J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD MAR PY 2015 VL 56 IS 3 BP 352 EP 359 DI 10.1016/j.jadohealth.2014.12.001 PG 8 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA CC2AR UT WOS:000350147500015 PM 25703323 ER PT J AU Jorakate, P Higdon, M Kaewpan, A Makprasert, S Yuenprakhon, S Tawisaid, K Dejsirilert, S Whistler, T Baggett, HC AF Jorakate, Possawat Higdon, Melissa Kaewpan, Anek Makprasert, Sirirat Yuenprakhon, Somkhit Tawisaid, Kittisak Dejsirilert, Surang Whistler, Toni Baggett, Henry C. TI Contribution of the BacT/Alert MB Mycobacterium Bottle to Bloodstream Infection Surveillance in Thailand: Added Yield for Burkholderia pseudomallei SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID INTRACELLULAR SURVIVAL; BACTEREMIA; FUNGEMIA; SYSTEMS AB Community-acquired bloodstream infections cause substantial morbidity and mortality worldwide, but microbiology capacity and surveillance limitations have challenged good descriptions of pathogen distribution in many regions, including Southeast Asia. Active surveillance for bloodstream infections has been conducted in two rural Thailand provinces for > 7 years. Blood specimens were divided into two culture bottles, one optimized for aerobic growth (F bottle) and a second for enhanced growth of mycobacteria (MB bottle), and processed with the BactT/Alert 3D system. Because the routine use of MB culture bottles is resource intensive (expensive and requires prolonged incubation), we assessed the added yield of MB bottles by comparing the proportion of pathogens detected by MB versus that by F bottles from 2005 to 2012. Of 63,066 blood cultures, 7,296 (12%) were positive for at least one pathogen; the most common pathogens were Escherichia coli (28%), Burkholderia pseudomallei (11%), Klebsiella pneumoniae (9%), and Staphylococcus aureus (6%). Two bottles improved the yield overall, but the added yield attributable to the MB bottles was limited to a few pathogens. In addition to the detection of mycobacteria and some fungi, MB bottles improved the detection of B. pseudomallei (27% [ MB] versus 8% [F]; P < 0.0001), with added benefit if therapy was initiated prior to the blood culture. The targeted use of MB bottles is warranted for patients at risk for mycobacterial and fungal infections and for infection with B. pseudomallei, a common cause of septicemia in Thailand. C1 [Jorakate, Possawat; Higdon, Melissa; Kaewpan, Anek; Makprasert, Sirirat; Whistler, Toni; Baggett, Henry C.] Thailand Minist Publ Hlth US Ctr Dis Control & Pr, Global Dis Detect, Nonthaburi, Thailand. [Whistler, Toni; Baggett, Henry C.] CDC, Div Global Hlth Protect, Atlanta, GA 30333 USA. [Yuenprakhon, Somkhit] Sa Kaeo Crown Prince Hosp, Sa Kaeo, Thailand. [Tawisaid, Kittisak] Nakhon Phanom Prov Hosp, Nakhon Phanom, Thailand. [Dejsirilert, Surang] Minist Publ Hlth, Natl Inst Hlth, Nonthaburi, Thailand. RP Jorakate, P (reprint author), Thailand Minist Publ Hlth US Ctr Dis Control & Pr, Global Dis Detect, Nonthaburi, Thailand. EM hqg0@cdc.gov FU CDC Foundation; Pneumococcal Vaccines Accelerated Development and Introduction Plan (PneumoADIP); GAVI Alliance based at the Johns Hopkins Bloomberg School of Public Health; Global Disease Detection program of the U.S. Centers for Disease Control and Prevention FX Support for this project was provided by the CDC Foundation, the Pneumococcal Vaccines Accelerated Development and Introduction Plan (PneumoADIP) (funded by the GAVI Alliance based at the Johns Hopkins Bloomberg School of Public Health), and the Global Disease Detection program of the U.S. Centers for Disease Control and Prevention. NR 20 TC 0 Z9 1 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAR PY 2015 VL 53 IS 3 BP 910 EP 914 DI 10.1128/JCM.02008-14 PG 5 WC Microbiology SC Microbiology GA CC2WD UT WOS:000350204600024 PM 25588650 ER PT J AU LeBouf, RF Coffey, CC AF LeBouf, Ryan F. Coffey, Christopher C. TI Effect of interferents on the performance of direct-reading organic vapor monitors SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION LA English DT Article ID PHOTOIONIZATION DETECTORS; CALIBRATION; EXPOSURE AB Direct-reading organic vapor monitors are often used to measure volatile organic compound concentrations in complex chemical gas mixtures. However, there is a paucity of data on the impact of multiple gases on monitor performance, even though it is known that monitor sensitivity may vary by chemical. This study investigated the effects of interferents on the performance of the MIRAN SapphIRe Portable Ambient Air Analyzer (SAP) and Century Portable Toxic Vapor Analyzer (TVA-1000) when sampling a specific agent of interest (cyclohexane). The TVA-1000 contained a dual detector: a photoionization detector (PID) and a flame ionization detector (FID). Three devices of each monitor were challenged with different combinations of cyclohexane and potential interferent vapors (hexane, methyl ethyl ketone, trichloroethylene, and toluene) at 21 degrees C and 90% relative humidity (RH), an extreme environmental condition. Five replicates at four target concentrations were tested: 30, 150, 300, and 475 ppm. Multiple proportions of cyclohexane to interferent enabled the determination of the interferent effect on monitor performance. The monitor concentrations were compared to reference concentrations measured using NIOSH Method 1500. Three scenarios were investigated: no response factor, cyclohexane response factor, and weighted-mixed response factor applied. False negatives occurred more frequently for PID (21.1%), followed by FID (4.8%) and SAP (0.2%). Measurements from all monitors generally had a positive bias compared to the reference measurements. Some monitor measurements exceeded twice the reference concentrations: PID (36.8%), SAP (19.8%), and FID (6.3%). Evaluation of the 95% confidence intervals indicated that performance of all monitors varied by concentration. In addition, the performance of the PID and SAP varied by presence of an interfering compound, especially toluene and hexane for the PID and trichloroethylene for the SAP. Variability and bias associated with all these monitors preclude supplanting traditional sorbent-based tube methods for measuring volatile organic compounds (VOCs), especially for compliance monitoring.Implications:Industrial hygienists need to use care when using any of the three monitor detection types to measure the concentration of unknown chemical mixtures. Monitor performance is affected by the presence of interferents. Application of manufacturer recommended response factors may not adequately scale measurements to minimize monitor bias when compared to standard reference methods. Users should calibrate their monitors to a known reference method prior to use, if possible. Each of the monitors has its own limitations, which should be considered to ensure quality measurements are reported. C1 [LeBouf, Ryan F.; Coffey, Christopher C.] NIOSH, Dept Hlth & Human Serv, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. RP LeBouf, RF (reprint author), NIOSH, Dept Hlth & Human Serv, Ctr Dis Control & Prevent, 1095 Willowdale Rd, Morgantown, WV 26505 USA. EM rlebouf@cdc.gov FU National Institute for Occupational Safety and Health FX This work was supported by the National Institute for Occupational Safety and Health. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institute for Occupational Safety and Health. Mention of any company or product does not constitute endorsement by the National Institute for Occupational Safety and Health (NIOSH). In addition, citations to websites external to NIOSH do not constitute NIOSH endorsement of the sponsoring organizations or their programs or products. Furthermore, NIOSH is not responsible for the content of these websites. NR 18 TC 1 Z9 1 U1 4 U2 9 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1096-2247 EI 2162-2906 J9 J AIR WASTE MANAGE JI J. Air Waste Manage. Assoc. PD MAR PY 2015 VL 65 IS 3 BP 261 EP 269 DI 10.1080/10962247.2014.986308 PG 9 WC Engineering, Environmental; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA CC1XN UT WOS:000350138800004 PM 25947122 ER PT J AU Cooper, CP Gelb, CA Lobb, K AF Cooper, Crystale Purvis Gelb, Cynthia A. Lobb, Kathleen TI Celebrity Appeal: Reaching Women to Promote Colorectal Cancer Screening SO JOURNAL OF WOMENS HEALTH LA English DT Article AB The Centers for Disease Control and Prevention's Screen for Life: National Colorectal Cancer Action Campaign works with the Entertainment Industry Foundation's National Colorectal Cancer Research Alliance to develop public service announcements (PSAs) featuring celebrities. Selection of Screen for Life celebrity spokespersons is based on a variety of factors, including their general appeal and personal connection to colorectal cancer. Screen for Life PSAs featuring celebrities have been disseminated exclusively through donated media placements and have been formatted for television, radio, print, and out-of-home displays such as dioramas in airports, other transit stations, and shopping malls. A 2012 national survey with women aged 50-75 years (n=772) investigated reported exposure to Screen for Life PSAs featuring actor Terrence Howard. In total, 8.3% of women recalled exposure to the PSAs. Celebrity spokespersons can attract the attention of both target audiences and media gatekeepers who decide which PSAs will receive donated placements. C1 [Cooper, Crystale Purvis] Soltera Ctr Canc Prevent & Control, Tucson, AZ USA. [Gelb, Cynthia A.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Lobb, Kathleen] Entertainment Ind Fdn, Los Angeles, CA USA. RP Gelb, CA (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway,Northeast Bldg 107,MS F-76, Atlanta, GA 30341 USA. EM cgelb@cdc.gov FU Intramural CDC HHS [CC999999] NR 10 TC 2 Z9 2 U1 1 U2 4 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 EI 1931-843X J9 J WOMENS HEALTH JI J. Womens Health PD MAR 1 PY 2015 VL 24 IS 3 BP 169 EP 173 DI 10.1089/jwh.2014.5084 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA CD0GV UT WOS:000350749600001 PM 25521047 ER PT J AU Barboza-Arguello, MD Umana-Solis, LM Azofeifa, A Valencia, D Flores, AL Rodriguez-Aguilar, S Alfaro-Calvo, T Mulinare, J AF de la Paz Barboza-Argueello, Maria Umana-Solis, Lila M. Azofeifa, Alejandro Valencia, Diana Flores, Alina L. Rodriguez-Aguilar, Sara Alfaro-Calvo, Thelma Mulinare, Joseph TI Neural Tube Defects in Costa Rica, 1987-2012: Origins and Development of Birth Defect Surveillance and Folic Acid Fortification SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Surveillance; Fortification; Costa Rica; Prevalence; Neural tube defects ID PREVENTION; REDUCTION; VITAMIN; FLOUR; CHILE AB Our aim was to provide a descriptive overview of how the birth defects surveillance and folic acid fortification programs were implemented in Costa Rica-through the establishment of the Registry Center for Congenital Anomalies (Centro de Registro de Enfermedades Cong,nitas-CREC), and fortification legislation mandates. We estimated the overall prevalence of neural tube defects (i.e., spina bifida, anencephaly and encephalocele) before and after fortification captured by CREC. Prevalence was calculated by dividing the total number of infants born with neural tube defects by the total number of live births in the country (1987-2012).A total of 1,170 newborns with neural tube defects were identified from 1987 to 2012 (1992-1995 data excluded); 628 were identified during the baseline pre-fortification period (1987-1991; 1996-1998); 191 during the fortification period (1999-2002); and 351 during the post-fortification time period (2003-2012). The overall prevalence of neural tube defects decreased from 9.8 per 10,000 live-births (95 % CI 9.1-10.5) for the pre-fortification period to 4.8 per 10,000 live births (95 % CI 4.3-5.3) for the post-fortification period. Results indicate a statistically significant (P < 0.05) decrease of 51 % in the prevalence of neural tube defects from the pre-fortification period to the post-fortification period. Folic acid fortification via several basic food sources has shown to be a successful public health intervention for Costa Rica. Costa Rica's experience can serve as an example for other countries seeking to develop and strengthen both their birth defects surveillance and fortification programs. C1 [de la Paz Barboza-Argueello, Maria; Umana-Solis, Lila M.] Inst Costarricense Invest & Ensenanza Nutr & Salu, CREC, Unidad Enfermedades Congenitas, Tres Rios, Cartago, Costa Rica. [Azofeifa, Alejandro; Valencia, Diana; Flores, Alina L.; Mulinare, Joseph] Ctr Dis Control & Prevent CDC, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Rodriguez-Aguilar, Sara] Inst Costarricense Invest & Ensenanza Nutr & Salu, Ctr Nacl Referencia Quim Clin, Tres Rios, Cartago, Costa Rica. [Alfaro-Calvo, Thelma] Inst Costarricense Invest & Ensenanza Nutr & Salu, Ctr Nacl Referencia Bromatol, Tres Rios, Cartago, Costa Rica. RP Barboza-Arguello, MD (reprint author), Inst Costarricense Invest & Ensenanza Nutr & Salu, CREC, Unidad Enfermedades Congenitas, Tres Rios, Cartago, Costa Rica. EM mbarboza@inciensa.sa.cr NR 30 TC 6 Z9 6 U1 0 U2 5 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 EI 1573-6628 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD MAR PY 2015 VL 19 IS 3 BP 583 EP 590 DI 10.1007/s10995-014-1542-8 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CB6VC UT WOS:000349763800018 ER PT J AU Correa, A Bardenheier, B Elixhauser, A Geiss, LS Gregg, E AF Correa, Adolfo Bardenheier, Barbara Elixhauser, Anne Geiss, Linda S. Gregg, Edward TI Trends in Prevalence of Diabetes Among Delivery Hospitalizations, United States, 1993-2009 SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Diabetes; Pregnancy; Prevalence; Surveillance ID RECOMMENDATIONS; PREGNANCY; MELLITUS; OBESITY; RATES; RISK AB To describe recent trends in prevalence of pre-existing diabetes mellitus (PDM) (i.e., type 1 or type 2 diabetes) and gestational diabetes mellitus (GDM) among delivery hospitalizations in the United States. Data on delivery hospitalizations from 1993 through 2009 were obtained from the Health Care Cost and Utilization Project (HCUP) Nationwide Inpatient Sample. Diagnosis-Related Group codes were used to identify deliveries and diagnosis codes on presence of diabetes. Rates of hospitalizations with diabetes were calculated per 100 deliveries by type of diabetes, hospital geographic region, patient's age, degree of urbanicity of patient's residence, categorized median household income for patient's ZIP Code, expected primary payer, and type of delivery. From 1993 to 2009, age-standardized prevalence of diabetes per 100 deliveries increased from 0.62 to 0.90 for PDM (trend p < 0.001) and from 3.09 to 5.57 for GDM (trend p < 0.001). In 2009, correlates of PDM at delivery included older age [40-44 vs. 15-24: odds ratio 6.45 (95 % CI 5.27-7.88)], Medicaid/Medicare versus private payment sources [1.77 (95 % CI 1.59-1.98)], patient's ZIP Code with a median household income in bottom quartile versus other quartiles [1.54 (95 % CI 1.41, 1.69)], and C-section versus vaginal delivery [3.36 (95 % CI 3.10-3.64)]. Correlates of GDM at delivery were similar. Among U.S. delivery hospitalizations, the prevalence of diabetes is increasing. In 2009, the prevalence of diabetes was higher among women in older age groups, living in ZIP codes with lower household incomes, or with public insurance. C1 [Correa, Adolfo] Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39213 USA. [Correa, Adolfo] Univ Mississippi, Med Ctr, Dept Pediat, Jackson, MS 39213 USA. [Bardenheier, Barbara; Geiss, Linda S.; Gregg, Edward] Ctr Dis Control & Prevent, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Elixhauser, Anne] Agcy Healthcare Res & Qual, Rockville, MD USA. RP Correa, A (reprint author), Univ Mississippi, Med Ctr, Dept Med, 350 Woodrow Wilson Dr,Suite 701, Jackson, MS 39213 USA. EM acorrea@umc.edu FU Intramural CDC HHS [CC999999] NR 25 TC 10 Z9 10 U1 1 U2 5 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 EI 1573-6628 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD MAR PY 2015 VL 19 IS 3 BP 635 EP 642 DI 10.1007/s10995-014-1553-5 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CB6VC UT WOS:000349763800024 PM 24996952 ER PT J AU Wendt, AS Jefferds, ME Perrine, CG Halleslevens, P Sullivan, KM AF Wendt, Amanda S. Jefferds, Maria E. Perrine, Cria G. Halleslevens, Patricia Sullivan, Kevin M. TI Obese women less likely to have low serum ferritin, Nicaragua SO PUBLIC HEALTH NUTRITION LA English DT Article DE Obesity; Serum ferritin; Iron deficiency; Inflammation; alpha(1)-Acid glycoprotein ID ACUTE-PHASE RESPONSE; C-REACTIVE PROTEIN; IRON-DEFICIENCY; SUBCLINICAL INFLAMMATION; OVERWEIGHT CHILDREN; REPRODUCTIVE AGE; PREVALENCE; ANEMIA; HYPOFERREMIA; ADOLESCENTS AB Objective: To examine the association between overweight and obesity and serum ferritin among women of reproductive age (15-49 years) in Nicaragua, considering the effect of a1-acid glycoprotein (AGP), a marker of inflammation. Design: We analysed data from the 2004-05 Nicaraguan Integrated Surveillance System for Nutrition Interventions. Three logistic regression models were analysed with low serum ferritin (< 15 mu g/l) as the dependent variable: (i) overweight or obese status and covariates; (ii) model 1 plus AGP; and (iii) model 1 restricted to only women with normal AGP levels (<= 1.0 g/l). Setting: Nicaragua. Subjects: Included in this analysis were 832 non-pregnant mother/caregivers (15-49 years) surveyed in 2004-2005. Results: In the sample, prevalence of overweight and obesity was 31.8 % and 19.2 %, respectively, and 27.6 % had low serum ferritin. In model 1, the adjusted OR of low serum ferritin was 0.74 (95 % CI 0.52, 1.05) for overweight women and 0.42 (95 % CI 0.26, 0.65) for obese women. In model 2, AGP was significantly independently associated with low serum ferritin (adjusted OR = 0.56, 95 % CI 0.34, 0.92) while the adjusted OR for overweight and obesity were largely unchanged. Excluding women with elevated AGP did not appreciably affect the relationship between overweight or obesity and low serum ferritin (model 3). Conclusions: Overall, in this population of reproductive-age women, obese women were less likely to have low serum ferritin levels, and this was independent of inflammation as measured by AGP. C1 [Wendt, Amanda S.] Emory Univ, Laney Grad Sch, Grad Div Biol & Biomed Sci, Nutr & Hlth Sci Program, Atlanta, GA 30322 USA. [Jefferds, Maria E.; Perrine, Cria G.; Sullivan, Kevin M.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA USA. [Halleslevens, Patricia] Minist Hlth, Managua, Nicaragua. [Sullivan, Kevin M.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. RP Wendt, AS (reprint author), Emory Univ, Laney Grad Sch, Grad Div Biol & Biomed Sci, Nutr & Hlth Sci Program, 1599 Clifton Rd NE Room 6-426, Atlanta, GA 30322 USA. EM awendt@emory.edu FU T-32 Reproductive, Perinatal, Pediatric Predoctoral Fellowship through the National Institutes of Health [2T32HD052460] FX This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors. The primary author was supported by a T-32 Reproductive, Perinatal, Pediatric Predoctoral Fellowship through the National Institutes of Health (Grant # 2T32HD052460). The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the US Centers for Disease Control and Prevention. NR 47 TC 2 Z9 2 U1 1 U2 3 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 1368-9800 EI 1475-2727 J9 PUBLIC HEALTH NUTR JI Public Health Nutr. PD MAR PY 2015 VL 18 IS 4 BP 736 EP 741 DI 10.1017/S1368980014000755 PG 6 WC Public, Environmental & Occupational Health; Nutrition & Dietetics SC Public, Environmental & Occupational Health; Nutrition & Dietetics GA CB6TW UT WOS:000349760600021 PM 24848519 ER PT J AU Escota, GV Patel, P Brooks, JT Bush, T Conley, L Baker, J Kojic, EM Hammer, J Onen, NF AF Escota, Gerome V. Patel, Pragna Brooks, John T. Bush, Tim Conley, Lois Baker, Jason Kojic, Erna Milunka Hammer, John Oenen, Nur F. CA SUN Study Investigators TI Short Communication: The Veterans Aging Cohort Study Index Is an Effective Tool to Assess Baseline Frailty Status in a Contemporary Cohort of HIV-Infected Persons SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID PHENOTYPE; MORTALITY; HOSPITALIZATION; THERAPY; ADULTS; RISK; AIDS; MEN AB The Veterans Aging Cohort Study (VACS) Index has previously been used to identify frail HIV-infected persons. However, data demonstrating the independent association between the VACS Index and baseline frailty status is lacking. Furthermore, the ability of the VACS Index to also reflect transitions in frailty status over time is unknown. We used data from the Study to Understand the Natural History of HIV and AIDS in the Era of Effective Therapy (SUN Study) to determine independent association of baseline frailty status with the VACS Index. We also evaluated VACS Index changes with frailty status transitions over time. We included 303 participants (median age 48 years, 76% men, 57% non-Hispanic white, 91% with plasma HIV RNA <400 copies/ml, and median CD4(+) cell count 595 cells/ml) with baseline and follow-up frailty assessments and used the Fried's criteria to define frailty status. There were 184 (61%) nonfrail, 112 (37%) prefrail, and seven (2%) frail participants at baseline. Prefrail/frail participants had significantly higher median VACS Index scores compared with nonfrail participants (18 versus 10, p<0.001). In multivariable analysis, prefrailty/frailty was independently associated with a higher VACS Index score (odds ratio 1.025, p=0.019). After a median follow-up of 12 months, participants who remained prefrail/frail compared to those who remained nonfrail continued to have higher median VACS Index scores. The VACS Index score did not significantly change with transitions in frailty status over time. Our study highlights the potential utility of the VACS Index in frailty assessment within the clinical setting. C1 [Escota, Gerome V.; Oenen, Nur F.] Washington Univ, Sch Med, St Louis, MO 63103 USA. [Patel, Pragna; Brooks, John T.; Bush, Tim; Conley, Lois] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. [Baker, Jason] Univ Minnesota, Hennepin Cty Med Ctr, Minneapolis, MN 55415 USA. [Kojic, Erna Milunka] Miriam Hosp, Providence, RI 02906 USA. [Hammer, John] Denver Infect Dis Consultants, Denver, CO USA. RP Escota, GV (reprint author), Washington Univ, Sch Med, Div Infect Dis, 660 South Euclid Ave, St Louis, MO 63103 USA. EM gescota@dom.wustl.edu NR 17 TC 8 Z9 8 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD MAR 1 PY 2015 VL 31 IS 3 BP 313 EP 317 DI 10.1089/aid.2014.0225 PG 5 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA CC0QW UT WOS:000350041800010 PM 25495766 ER PT J AU Davis, SM Anderson, BL Schulkin, J Jones, K Eng, JV Jones, JL AF Davis, Stephanie M. Anderson, Britta L. Schulkin, Jay Jones, Katherine Eng, Jodi Vanden Jones, Jeffrey L. TI Survey of obstetrician-gynecologists in the United States about toxoplasmosis: 2012 update SO ARCHIVES OF GYNECOLOGY AND OBSTETRICS LA English DT Article DE Toxoplasmosis; Parasitology; Zoonotic diseases; Infectious diseases, KAP (Knowledge, Aptitude, Perception) ID CONGENITAL TOXOPLASMOSIS; GONDII INFECTION; PRENATAL TREATMENT; RISK-FACTORS; PREGNANCY; WOMEN; TRANSMISSION; MULTICENTER; SPIRAMYCIN; DIAGNOSIS AB Toxoplasmosis, caused by the parasite Toxoplasma gondii, can have serious impacts on fetal development in the setting of acute maternal primary infection. The American College of Obstetricians and Gynecologists (ACOG) sought to determine current knowledge, practices, opinions, and educational preferences regarding T. gondii infection in pregnancy among ACOG members practicing prenatal care. ACOG sent a survey to 1,056 members chosen by stratified random sampling from membership lists, including 370 participants and 686 non-participants in the Collaborative Ambulatory Research Network (CARN). Mailings were sent up to four times to nonresponders. Survey minimum response rates were 40.3 % (CARN) and 19.7 % (non-CARN); response rates adjusted for imputed non-eligibility were 59.7 % (CARN) and 22.6 % (non-CARN). Among providers, 80.2 % had diagnosed no acute maternal T. gondii infections in the past 5 years, 12.7 % correctly identified the screening role of the Toxoplasma avidity test, 42.6 % performed serologic T. gondii screening for at least some asymptomatic pregnant women, and 62.1 % of those who so did used appropriate approaches. Providers in the northeastern United States were 2.02 times more likely to routinely screen than those in the west (p = 0.025) and female providers were 1.48 times more likely than male providers (p = 0.047). The potential educational interventions considered useful by the most practitioners were updated ACOG guidelines on screening (81.4 %) and management (71.7 %) for acute T. gondii infection in pregnancy. ACOG members would benefit from educational efforts targeted at risk factor counseling and screening approaches. C1 [Davis, Stephanie M.] Ctr Dis Control & Prevent, Div Global HIV AIDS, HIV Prevent Branch, Atlanta, GA 30333 USA. [Anderson, Britta L.; Schulkin, Jay; Jones, Katherine] Amer Coll Obstetricians & Gynecologists, Dept Res, Washington, DC 20024 USA. [Eng, Jodi Vanden; Jones, Jeffrey L.] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA USA. RP Davis, SM (reprint author), Ctr Dis Control & Prevent, Div Global HIV AIDS, HIV Prevent Branch, Atlanta, GA 30333 USA. EM vic6@cdc.gov; banderson@acog.org; jschulkin@acog.org; kjones@acog.org; jev8@cdc.gov; jlj1@cdc.gov FU U.S. Department of Health and Human Services, Health Resources and Services Administration, Maternal and Child Health Research Program [UA6MC19010] FX This study is funded in part by grant UA6MC19010, through the U.S. Department of Health and Human Services, Health Resources and Services Administration, Maternal and Child Health Research Program. NR 39 TC 2 Z9 2 U1 2 U2 9 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0932-0067 EI 1432-0711 J9 ARCH GYNECOL OBSTET JI Arch. Gynecol. Obstet. PD MAR PY 2015 VL 291 IS 3 BP 545 EP 555 DI 10.1007/s00404-014-3450-y PG 11 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA CB3TP UT WOS:000349552000014 PM 25205181 ER PT J AU Harpaz, R Leung, JW Brown, CJ Zhou, FJ AF Harpaz, Rafael Leung, Jessica W. Brown, Cedric J. Zhou, Fang Jun TI Psychological Stress as a Trigger for Herpes Zoster: Might the Conventional Wisdom Be Wrong? SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE zoster; shingles; stress; self-controlled case series; healthcare seeking ID RISK-FACTORS; INTENSIVE-CARE; REACTIVATION; ASTRONAUTS; VIRUS AB The causes for zoster remain largely unknown. Psychological stress is one commonly considered risk factor. We used self-controlled case series methods to look for increases in zoster following death or catastrophic health event occurring in a previously healthy spouse. We found no increase, although this stressor led to increased mental health visits. C1 [Harpaz, Rafael; Leung, Jessica W.; Brown, Cedric J.; Zhou, Fang Jun] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Harpaz, R (reprint author), Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,MS A-34, Atlanta, GA 30333 USA. EM rzh6@cdc.gov NR 18 TC 3 Z9 3 U1 1 U2 7 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAR 1 PY 2015 VL 60 IS 5 BP 781 EP 785 DI 10.1093/cid/ciu889 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CB6VY UT WOS:000349766100018 PM 25389252 ER PT J AU O'Leary, A Jemmott, JB Jemmott, LS Teitelman, A Heeren, GA Ngwane, Z Icard, LD Lewis, DA AF O'Leary, Ann Jemmott, John B., III Jemmott, Loretta S. Teitelman, Anne Heeren, G. Anita Ngwane, Zolani Icard, Larry D. Lewis, David A. TI Associations Between Psychosocial Factors and Incidence of Sexually Transmitted Disease Among South African Adolescents SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; HIV-INFECTION; CAPE-TOWN; WOMEN; RISK; INTERVENTION; TRANSMISSION; GENDER; PREVENTION; AMERICAN AB Background: Adolescents living in South Africa are at high risk for HIV and other sexually transmitted diseases (STDs). The present study sought to identify correlates of curable STD incidence among a cohort of adolescents in Eastern Cape Province, South Africa. Methods: Data were collected in conjunction with an HIV/STD prevention intervention randomized controlled trial. 1 At 54 months postintervention, curable STD incidence (gonorrhea, chlamydial infection, and trichomoniasis) was assayed and self-report measures of potential correlates of STD incidence were collected. Results: Participants were adolescents reporting at least 1 sexual partner in the past 3 months (n = 659). As expected, univariate analyses revealed that girls were more likely than boys to have an STD. In addition, intimate partner violence, unprotected sex, and having older partners were associated with incident STD. In Poisson multiple regression analyses, sex (risk ratio [RR], 4.00; 95% confidence interval [CI], 2.51-6.39), intimate partner violence (RR, 1.23; 95% CI, 1.12-1.35), unprotected sex (RR, 1.42; 95% CI, 1.09-2.01), and multiple partners (RR, 1.70; 95% CI, 1.11-2.61), but not partner's age (RR, 1.00; 95% CI, 0.94-1.07) were associated with incident STD, adjusting for 42-month STD prevalence. Binge drinking, forced sex, and agewere unrelated to STD incidence in both analyses. Interactions between sex and the hypothesized correlates were nonsignificant, suggesting that sex did not modify these relationships. Conclusions: Interventions to reduce HIV/STD incidence among adolescents in South Africa should address the risk associated with sex, unprotected sex, intimate partner violence, and multiple partnerships. C1 [O'Leary, Ann] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. [Jemmott, John B., III; Jemmott, Loretta S.; Teitelman, Anne; Heeren, G. Anita] Univ Penn, Philadelphia, PA 19104 USA. [Ngwane, Zolani] Haverford Coll, Haverford, PA 19041 USA. [Icard, Larry D.] Temple Univ, Philadelphia, PA 19122 USA. [Lewis, David A.] Natl Inst Communicable Dis, Ctr HIV & Sexually Transmitted Infect, Johannesburg, South Africa. [Lewis, David A.] Univ Sydney, Westmead Clin Sch, Ctr Infect Dis & Microbiol, Sydney, NSW 2006, Australia. [Lewis, David A.] Univ Sydney, Westmead Clin Sch, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia. RP O'Leary, A (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS, 1600 Clifton Rd,MS E-37, Atlanta, GA 30329 USA. EM aoleary@cdc.gov FU National Institute of Mental Health [R01 MH065867] FX This study was funded by Research Grant R01 MH065867 from the National Institute of Mental Health. The National Institute of Mental Health had no role in the design and conduct of the study, preparation, review, or approval of the manuscript. The findings and conclusions are those of the authors and do not represent the views of the Centers for Disease Control and Prevention. NR 33 TC 2 Z9 2 U1 5 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD MAR PY 2015 VL 42 IS 3 BP 135 EP 139 DI 10.1097/OLQ.0000000000000247 PG 5 WC Infectious Diseases SC Infectious Diseases GA CB5XM UT WOS:000349701300006 PM 25668645 ER PT J AU Gallo, MF Warner, L Hobbs, MM Jamieson, DJ Hylton-Kong, T Steiner, MJ AF Gallo, Maria F. Warner, Lee Hobbs, Marcia M. Jamieson, Denise J. Hylton-Kong, Tina Steiner, Markus J. TI Differences in Misreporting of Sexual Behavior Over Time: Implications for HIV Trials SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID PROSTATE-SPECIFIC ANTIGEN; REPORTED CONDOM USE; TRANSMITTED INFECTION; BIOMARKER VALIDATION; SEMEN EXPOSURE; WOMEN; INTERCOURSE; WORKERS AB We used data from a prospective study of 300 women attending a sexually transmitted infection clinic in Kingston, Jamaica, to compare participant self-report of recent semen exposure to actual semen exposure measured by prostate-specific antigen in vaginal swabs. Underreporting of semen exposure was significantly more frequent at follow-up than baseline, suggesting that the accuracy of reports of sexual behavior may vary over time. C1 [Gallo, Maria F.] Ohio State Univ, Coll Publ Hlth, Div Epidemiol, Columbus, OH 43210 USA. [Warner, Lee; Jamieson, Denise J.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA. [Hobbs, Marcia M.] Univ N Carolina, Dept Med, Chapel Hill, NC USA. [Hylton-Kong, Tina] Jamaica Minist Hlth, ERTU, CHC, Kingston, Jamaica. [Steiner, Markus J.] FHI 360, Div Clin Sci, Durham, NC USA. RP Gallo, MF (reprint author), Ohio State Univ, Coll Publ Hlth, Div Epidemiol, 324 Cunz Hall,1841 Neil Ave, Columbus, OH 43210 USA. EM mgallo@cph.osu.edu FU Division of Reproductive Health, Centers for Disease Control and Prevention [GPO-A-00-05-00022]; Southeastern Sexually Transmitted Infections Cooperative Research Center of the National Institute of Allergy and Infectious Diseases [U19-AI031496] FX The trial was funded by the Division of Reproductive Health, Centers for Disease Control and Prevention, through a cooperative agreement maintained by US Agency for International Development with FHI 360 (Contraceptive and Reproductive Health Technology Research and Utilization Project, Agreement No. GPO-A-00-05-00022). Laboratory activities for the study were supported in part by the Southeastern Sexually Transmitted Infections Cooperative Research Center of the National Institute of Allergy and Infectious Diseases (U19-AI031496). The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. The authors have no conflicts of interests. NR 18 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD MAR PY 2015 VL 42 IS 3 BP 160 EP 161 DI 10.1097/OLQ.0000000000000243 PG 2 WC Infectious Diseases SC Infectious Diseases GA CB5XM UT WOS:000349701300010 PM 25668649 ER PT J AU Grajewski, B Whelan, EA Lawson, CC Hein, MJ Waters, MA Anderson, JL MacDonald, LA Mertens, CJ Tseng, CY Cassinelli, RT Luo, L AF Grajewski, Barbara Whelan, Elizabeth A. Lawson, Christina C. Hein, Misty J. Waters, Martha A. Anderson, Jeri L. MacDonald, Leslie A. Mertens, Christopher J. Tseng, Chih-Yu Cassinelli, Rick T., II Luo, Lian TI Miscarriage Among Flight Attendants SO EPIDEMIOLOGY LA English DT Article ID SPONTANEOUS-ABORTION; COSMIC-RADIATION; PREGNANCY OUTCOMES; EXPOSURE; DISRUPTION; EVENTS; RISK AB Background: Cosmic radiation and circadian disruption are potential reproductive hazards for flight attendants. Methods: Flight attendants from 3 US airlines in 3 cities were interviewed for pregnancy histories and lifestyle, medical, and occupational covariates. We assessed cosmic radiation and circadian disruption from company records of 2 million individual flights. Using Cox regression models, we compared respondents (1) by levels of flight exposures and (2) to teachers from the same cities, to evaluate whether these exposures were associated with miscarriage. Results: Of 2654 women interviewed (2273 flight attendants and 381 teachers), 958 pregnancies among 764 women met study criteria. A hypothetical pregnant flight attendant with median first-trimester exposures flew 130 hours in 53 flight segments, crossed 34 time zones, and flew 15 hours during her home-base sleep hours (10 pm-8 am), incurring 0.13 mGy absorbed dose (0.36 mSv effective dose) of cosmic radiation. About 2% of flight attendant pregnancies were likely exposed to a solar particle event, but doses varied widely. Analyses suggested that cosmic radiation exposure of 0.1 mGy or more may be associated with increased risk of miscarriage in weeks 9-13 (odds ratio = 1.7 [95% confidence interval = 0.95-3.2]). Risk of a first-trimester miscarriage with 15 hours or more of flying during home-base sleep hours was increased (1.5 [1.1-2.2]), as was risk with high physical job demands (2.5 [1.5-4.2]). Miscarriage risk was not increased among flight attendants compared with teachers. Conclusions: Miscarriage was associated with flight attendant work during sleep hours and high physical job demands and may be associated with cosmic radiation exposure. C1 [Grajewski, Barbara; Whelan, Elizabeth A.; Lawson, Christina C.; Hein, Misty J.; Waters, Martha A.; Anderson, Jeri L.; MacDonald, Leslie A.; Tseng, Chih-Yu; Cassinelli, Rick T., II; Luo, Lian] NIOSH, Cincinnati, OH 45226 USA. [Mertens, Christopher J.] NASA, Hampton, VA USA. RP Grajewski, B (reprint author), Ctr Dis Control & Prevent, Natl Inst Occupat Safety & Hlth R15, 1090 Tusculum Ave, Cincinnati, OH 45226 USA. EM bag2@cdc.gov FU Federal Aviation Administration; Department of Defense Women's Health Research Program FX Supported, in part, by interagency agreements with the Federal Aviation Administration and the Department of Defense Women's Health Research Program. NR 40 TC 9 Z9 9 U1 2 U2 12 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1044-3983 EI 1531-5487 J9 EPIDEMIOLOGY JI Epidemiology PD MAR PY 2015 VL 26 IS 2 BP 192 EP 203 DI 10.1097/EDE.0000000000000225 PG 12 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CB1PO UT WOS:000349400300025 PM 25563432 ER PT J AU Whitcomb, RC Ansari, AJ Buzzell, JJ McCurley, MC Miller, CW Smith, JM Evans, DL AF Whitcomb, Robert C., Jr. Ansari, Armin J. Buzzell, Jennifer J. McCurley, M. Carol Miller, Charles W. Smith, James M. Evans, D. Lynn TI A PUBLIC HEALTH PERSPECTIVE ON THE US RESPONSE TO THE FUKUSHIMA RADIOLOGICAL EMERGENCY SO HEALTH PHYSICS LA English DT Article DE dose assessment; emergency planning; public information; radiation ID NUCLEAR-POWER-PLANT; ACCIDENT AB On 11 March 2011, northern Japan was struck by first a magnitude 9.0 earthquake off the eastern coast and then by an ensuing tsunami. At the Fukushima Dai-ichi Nuclear Power Plant (NPP), these twin disasters initiated a cascade of events that led to radionuclide releases. Radioactive material from Japan was subsequently transported to locations around the globe, including the U.S. The levels of radioactive material that arrived in the U.S. were never large enough to cause health effects, but the presence of this material in the environment was enough to require a response from the public health community. Events during the response illustrated some U.S. preparedness challenges that previously had been anticipated and others that were newly identified. Some of these challenges include the following: (1) Capacity, including radiation health experts, for monitoring potentially exposed people for radioactive contamination are limited and may not be adequate at the time of a large-scale radiological incident; (2) there is no public health authority to detain people contaminated with radioactive materials; (3) public health and medical capacities for response to radiation emergencies are limited; (4) public health communications regarding radiation emergencies can be improved to enhance public health response; (5) national and international exposure standards for radiation measurements (and units) and protective action guides lack uniformity; (6) access to radiation emergency monitoring data can be limited; and (7) the Strategic National Stockpile may not be currently prepared to meet the public health need for KI in the case of a surge in demand from a large-scale radiation emergency. Members of the public health community can draw on this experience to improve public health preparedness. C1 [Whitcomb, Robert C., Jr.; Ansari, Armin J.; Buzzell, Jennifer J.; McCurley, M. Carol] Ctr Dis Control & Prevent, Radiat Studies Branch, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. RP Whitcomb, RC (reprint author), Ctr Dis Control & Prevent, Radiat Studies Branch, 4770 Buford Highway NE,Mailstop F58, Atlanta, GA 30341 USA. EM byw3@cdc.gov FU Intramural CDC HHS [CC999999] NR 24 TC 3 Z9 3 U1 1 U2 17 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD MAR PY 2015 VL 108 IS 3 BP 357 EP 363 DI 10.1097/HP.0000000000000198 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA CB2IY UT WOS:000349451800008 PM 25627948 ER PT J AU Venuto, M Garcia, K Halbrook, B AF Venuto, Margaret Garcia, Kristin Halbrook, Brenda TI Analyses of the Contributing Factors Associated With Foodborne Outbreaks in School Settings (2000-2010) SO JOURNAL OF ENVIRONMENTAL HEALTH LA English DT Article ID UNITED-STATES; FOOD SAFETY; DISEASE; SURVEILLANCE AB State-reported school foodborne outbreaks account for about 3.8% (n = 464) of all outbreaks and 8.2% (n = 20,667) of all illnesses reported to the Centers for Disease Control and Prevention's Foodborne Disease Outbreak Surveillance System. Of 464 school foodborne outbreaks, 122 (26%) outbreaks, 7,603 illnesses, and 301 reported food safety errors met the criteria for inclusion in the analyses. The purpose of the authors' study was to examine the role of contributing factors in school foodborne outbreaks. Contamination factors accounted for the greatest proportion (49.2%) of outbreaks involving some level of food handling interaction by a school food service worker, followed by proliferation (34.9%) and survival factors (15.9%). Over 56% of all illnesses were associated with norovirus and food service worker practices. The results of these analyses highlight the importance of effective food safety education programs that focus on the role of contributing factors and prevention of foodborne disease from food safety errors. C1 [Venuto, Margaret] Ctr Dis Control & Prevent, Div State & Local Readiness, Off Publ Hlth Preparedness & Response, Atlanta, GA 30333 USA. [Garcia, Kristin; Halbrook, Brenda] Food & Nutr Serv, Off Food Safety, USDA, Washington, DC USA. RP Venuto, M (reprint author), Ctr Dis Control & Prevent, Div State & Local Readiness, Off Publ Hlth Preparedness & Response, Atlanta, GA 30333 USA. EM yku9@cdc.gov NR 19 TC 1 Z9 1 U1 3 U2 9 PU NATL ENVIRON HEALTH ASSOC PI DENVER PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA SN 0022-0892 J9 J ENVIRON HEALTH JI J. Environ. Health PD MAR PY 2015 VL 77 IS 7 BP 16 EP 20 PG 5 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA CB5IN UT WOS:000349660800004 PM 25796698 ER PT J AU Whitfield, GP Wendel, AM AF Whitfield, Geoffrey P. Wendel, Arthur M. TI Modeling Health Impacts of the Transportation Built Environment: Challenges and Opportunities SO JOURNAL OF ENVIRONMENTAL HEALTH LA English DT Editorial Material RP Whitfield, GP (reprint author), Natl Ctr Environm Hlth, Div Emergency & Environm Hlth Serv, 4770 Buford Highway NE,MS F-58, Atlanta, GA 30341 USA. EM xdh5@cdc.gov FU Intramural CDC HHS [CC999999] NR 6 TC 0 Z9 0 U1 1 U2 2 PU NATL ENVIRON HEALTH ASSOC PI DENVER PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA SN 0022-0892 J9 J ENVIRON HEALTH JI J. Environ. Health PD MAR PY 2015 VL 77 IS 7 BP 36 EP 37 PG 2 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA CB5IN UT WOS:000349660800008 PM 25796702 ER PT J AU Burt, P DeWitt, S AF Burt, Preston DeWitt, Shannon TI Environmental Information for Everyone SO JOURNAL OF ENVIRONMENTAL HEALTH LA English DT Editorial Material RP Burt, P (reprint author), CDC, Carter Consulting Inc, Contractor Environm Publ Hlth Tracking Branch, DEHHE, 4770 Buford Highway NE,MS F-60, Atlanta, GA 30341 USA. EM pburt@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATL ENVIRON HEALTH ASSOC PI DENVER PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA SN 0022-0892 J9 J ENVIRON HEALTH JI J. Environ. Health PD MAR PY 2015 VL 77 IS 7 BP 38 EP 40 PG 3 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA CB5IN UT WOS:000349660800009 PM 25796703 ER PT J AU Goga, AE Dinh, TH Jackson, DJ Lombard, C Delaney, KP Puren, A Sherman, G Woldesenbet, S Ramokolo, V Crowley, S Doherty, T Chopra, M Shaffer, N Pillay, Y AF Goga, Ameena E. Thu-Ha Dinh Jackson, Debra J. Lombard, Carl Delaney, Kevin P. Puren, Adrian Sherman, Gayle Woldesenbet, Selamawit Ramokolo, Vundli Crowley, Siobhan Doherty, Tanya Chopra, Mickey Shaffer, Nathan Pillay, Yogan CA South Africa PMTCT Evaluation TI First population-level effectiveness evaluation of a national programme to prevent HIV transmission from mother to child, South Africa SO JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; OPERATIONAL EFFECTIVENESS; IMMUNIZATION CLINICS; EARLY-DIAGNOSIS; NEVIRAPINE; INFANTS; ZIDOVUDINE; SURVIVAL AB Background There is a paucity of data on the national population-level effectiveness of preventing mother-to-child transmission (PMTCT) programmes in high-HIV-prevalence, resource-limited settings. We assessed national PMTCT impact in South Africa (SA), 2010. Methods A facility-based survey was conducted using a stratified multistage, cluster sampling design. A nationally representative sample of 10 178 infants aged 4-8 weeks was recruited from 565 clinics. Data collection included caregiver interviews, record reviews and infant dried blood spots to identify HIV-exposed infants (HEI) and HIV-infected infants. During analysis, self-reported antiretroviral (ARV) use was categorised: 1a: triple ARV treatment; 1b: azidothymidine > 10 weeks; 2a: azidothymidine <= 10 weeks; 2b: incomplete ARV prophylaxis; 3a: no antenatal ARV and 3b: missing ARV information. Findings were adjusted for non-response, survey design and weighted for live-birth distributions. Results Nationally, 32% of live infants were HEI; early mother-to-child transmission (MTCT) was 3.5% (95% CI 2.9% to 4.1%). In total 29.4% HEI were born to mothers on triple ARV treatment (category 1a) 55.6% on prophylaxis (1b, 2a, 2b), 9.5% received no antenatal ARV (3a) and 5.5% had missing ARV information (3b). Controlling for other factors groups, 1b and 2a had similar MTCT to 1a (Ref; adjusted OR (AOR) for 1b, 0.98, 0.52 to 1.83; and 2a, 1.31, 0.69 to 2.48). MTCT was higher in group 2b (AOR 3.68, 1.69 to 7.97). Within group 3a, early MTCT was highest among breastfeeding mothers 11.50% (4.67% to 18.33%) for exclusive breast feeding, 11.90% (7.45% to 16.35%) for mixed breast feeding, and 3.45% (0.53% to 6.35%) for no breast feeding). Antiretroviral therapy or > 10 weeks prophylaxis negated this difference (MTCT 3.94%, 1.98% to 5.90%; 2.07%, 0.55% to 3.60% and 2.11%, 1.28% to 2.95%, respectively). Conclusions SA, a high-HIV-prevalence middle income country achieved < 5% MTCT by 4-8 weeks post partum. The long-term impact on PMTCT on HIV-free survival needs urgent assessment. C1 [Goga, Ameena E.; Woldesenbet, Selamawit; Ramokolo, Vundli; Doherty, Tanya] MRC, Hlth Syst Res Unit, Cape Town, South Africa. [Goga, Ameena E.] Univ Pretoria, Dept Paediat & Child Hlth, Kalafong Hosp, ZA-0002 Pretoria, South Africa. [Thu-Ha Dinh] Ctr Dis Control & Prevent, Div Global HIV AIDS, Ctr Global Hlth, Atlanta, GA USA. [Jackson, Debra J.; Doherty, Tanya] Univ Western Cape, Sch Publ Hlth, ZA-7535 Bellville, South Africa. [Jackson, Debra J.; Chopra, Mickey] UNICEF New York, New York, NY USA. [Lombard, Carl] MRC, Biostat Unit, Cape Town, South Africa. [Lombard, Carl] Sch Publ Hlth & Family Med, Cape Town, South Africa. [Delaney, Kevin P.] Ctr Dis Control & Prevent, Div HIV AID Prevent, Natl Ctr HIV Hepatitis STD & TB Prevent, Atlanta, GA USA. [Puren, Adrian; Sherman, Gayle] Natl Inst Communicable Dis, Div Natl Hlth Lab Serv, Johannesburg, South Africa. [Sherman, Gayle] Univ Witwatersrand, Fac Hlth Sci, Dept Paediat & Child Hlth, Johannesburg, South Africa. [Crowley, Siobhan] UNICEF South Africa, Pretoria, South Africa. [Doherty, Tanya] Univ Witwatersrand, Sch Publ Hlth, Johannesburg, South Africa. [Shaffer, Nathan] World Hlth Org, Geneva, Switzerland. [Pillay, Yogan] Natl Dept Hlth, Pretoria, South Africa. RP Goga, AE (reprint author), Francie van Zyl Dr, ZA-7505 Cape Town, South Africa. EM Ameena.Goga@mrc.ac.za FU CDC [1U2GPS001137-02, 1U2GPS001137-03]; MRC [1U2GPS001137-02, 1U2GPS001137-03]; UNICEF; National Department of Health; National Research Foundation, South Africa FX This evaluation was primarily supported by the President's Emergency Plan for AIDS Relief under the Cooperative Agreement between CDC and MRC (1U2GPS001137-02 and 1U2GPS001137-03). UNICEF, a cosponsor, provided technical support to protocol development, development and implementation of mobile technology for data collection and manuscript writing. The National Department of Health funded all the 6-week PCR tests. TD and DJJ were supported by the National Research Foundation, South Africa. NR 41 TC 19 Z9 19 U1 0 U2 6 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0143-005X EI 1470-2738 J9 J EPIDEMIOL COMMUN H JI J. Epidemiol. Community Health PD MAR PY 2015 VL 69 IS 3 BP 240 EP 248 DI 10.1136/jech-2014-204535 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CB3PZ UT WOS:000349542100008 PM 25371480 ER PT J AU Mackenzie-Impoinvil, L Impoinvil, DE Galbraith, SE Dillon, RJ Ranson, H Johnson, N Fooks, AR Solomon, T Baylis, M AF Mackenzie-Impoinvil, L. Impoinvil, D. E. Galbraith, S. E. Dillon, R. J. Ranson, H. Johnson, N. Fooks, A. R. Solomon, T. Baylis, M. TI Evaluation of a temperate climate mosquito, Ochlerotatus detritus (=Aedes detritus), as a potential vector of Japanese encephalitis virus SO MEDICAL AND VETERINARY ENTOMOLOGY LA English DT Article DE Ochlerotatus detritus; British mosquito; Japanese encephalitis virus; vector competence ID WEST-NILE-VIRUS; CULEX-MODESTUS; SINDBIS-VIRUS; USUTU-VIRUS; FEVER VIRUS; INFECTION; TRANSMISSION; CULICIDAE; DIPTERA; SALIVA AB The U.K. has not yet experienced a confirmed outbreak of mosquito-borne virus transmission to people or livestock despite numerous autochthonous epizootic and human outbreaks of mosquito-borne diseases on the European mainland. Indeed, whether or not British mosquitoes are competent to transmit arboviruses has not been established. Therefore, the competence of a local (temperate) British mosquito species, Ochlerotatus detritus (=Aedes detritus) (Diptera: Culicidae) for transmission of a member of the genus Flavivirus, Japanese encephalitis virus (JEV) as a model for mosquito-borne virus transmission was assessed. The JEV competence in a laboratory strain of Culex quinquefasciatus (Diptera: Culicidae), a previously incriminated JEV vector, was also evaluated as a positive control. Ochlerotatus detritus adults were reared from field-collected juvenile stages. In oral infection bioassays, adult females developed disseminated infections and were able to transmit virus as determined by the isolation of virus in saliva secretions. When pooled at 7-21days post-infection, 13% and 25% of O.detritus were able to transmit JEV when held at 23 degrees C and 28 degrees C, respectively. Similar results were obtained for C.quinquefasciatus. To our knowledge, this study is the first to demonstrate that a British mosquito species, O.detritus, is a potential vector of an exotic flavivirus. C1 [Mackenzie-Impoinvil, L.; Impoinvil, D. E.; Solomon, T.] Univ Liverpool, Inst Infect & Global Hlth, Dept Clin Infect Microbiol & Immunol, Brain Infect Grp, Liverpool L69 3BX, Merseyside, England. [Impoinvil, D. E.; Baylis, M.] Univ Liverpool, Inst Infect & Global Hlth, Dept Epidemiol & Populat Hlth, Climate & Infect Dis Animals Grp, Liverpool L69 3BX, Merseyside, England. [Galbraith, S. E.] Leeds Metropolitan Univ, Dept Biomed Sci, Leeds LS1 3HE, W Yorkshire, England. [Dillon, R. J.] Univ Lancaster, Sch Hlth & Med, Lancaster, England. [Ranson, H.] Univ Liverpool, Liverpool Sch Trop Med, Vector Grp, Liverpool L3 5QA, Merseyside, England. [Johnson, N.; Fooks, A. R.] Anim Hlth & Vet Labs Agcy, Wildlife Zoonoses & Vector Borne Dis Res Grp, Addlestone, Surrey, England. [Fooks, A. R.] Univ Liverpool, Dept Clin Infect Microbiol & Immunol, Liverpool L69 3BX, Merseyside, England. [Solomon, T.; Baylis, M.] Natl Inst Hlth Res, Hlth Protect Res Unit Emerging & Zoonot Infect, Liverpool, Merseyside, England. RP Impoinvil, DE (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Entomol Branch, Mail Stop G49,1600 Clifton Rd, Atlanta, GA 30329 USA. EM xda6@cdc.gov RI APHA, Staff publications/E-6082-2010; Fooks, Anthony/F-5418-2010; Johnson, Nicholas/B-4654-2011; OI Johnson, Nicholas/0000-0002-6106-9373; Dillon, Rod/0000-0002-3551-0030; Ranson, Hilary/0000-0003-2332-8247; Galbraith, Sareen/0000-0002-1009-6179; Solomon, Tom/0000-0001-7266-6547; Baylis, Matthew/0000-0003-0335-187X FU Animal Health and Veterinary Laboratory Agency's (AHVLA) Internal PhD programme grant [SE0416]; European Commission Seventh Framework Programme under ANTIGONE [278976]; Leverhulme Trust Research Leadership Award [F/0025/AC]; Wellcome Trust Award FX LM-I was supported by an Animal Health and Veterinary Laboratory Agency's (AHVLA) Internal PhD programme grant (project SE0416). Additional support was provided by the European Commission Seventh Framework Programme under ANTIGONE (project 278976), a Leverhulme Trust Research Leadership Award (F/0025/AC) to MB and a Wellcome Trust Award to TS. NR 48 TC 7 Z9 7 U1 2 U2 23 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0269-283X EI 1365-2915 J9 MED VET ENTOMOL JI Med. Vet. Entomol. PD MAR PY 2015 VL 29 IS 1 BP 1 EP 9 DI 10.1111/mve.12083 PG 9 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA CB1MR UT WOS:000349392300001 PM 25087926 ER PT J AU Scinicariello, F Buser, MC AF Scinicariello, F. Buser, M. C. TI Blood cadmium and depressive symptoms in young adults (aged 20-39 years) SO PSYCHOLOGICAL MEDICINE LA English DT Article DE Blood cadmium; blood lead; cigarette smoking; depressive symptoms; NHANES ID SECONDHAND SMOKE EXPOSURE; MENTAL-HEALTH; OCCUPATIONAL-EXPOSURE; GENERAL-POPULATION; UNITED-STATES; LEAD LEVELS; MALE RATS; BEHAVIOR; ANXIETY; WORKERS AB Background. Genetic and environmental factors contribute to the risk of depression and several studies have noted an association between tobacco smoke and depression. Cadmium is a neurotoxicant and the main source of nonoccupational exposure is tobacco smoke. Method. We conducted a cross-sectional analysis of data from 2892 young adult (aged 20-39 years) participants of the National Health and Nutrition Examination Survey (NHANES) 2007-2010. Multivariate logistic regressions, adjusted for age, sex, race/ethnicity, education, poverty income ratio (PIR), obesity, alcohol intake, blood lead (BPb) and smoking status, were used to analyze the association between blood cadmium (BCd) and depressive symptoms, as determined by the score on the nine-item Patient Health Questionnaire (PHQ-9). Results. Individuals in the highest BCd quartile had higher odds of having depressive symptoms [odds ratio (OR) 2.79, 95% confidence interval (CI) 1.84-4.25] than those in the lowest BCd quartile. Smoking status, but not BPb, was statistically significantly associated with depressive symptoms. Stratification by smoking status found that BCd was significantly associated with depressive symptoms in both non-smokers (OR 2.91, 95% CI 1.12-7.58) and current smokers (OR 2.69, 95% CI 1.13-6.42). Conclusions. This is the first study to report an association between BCd levels and depressive symptoms using a nationally representative sample. The association of cadmium with depressive symptoms was independent of smoking status. If this association is further confirmed, the continued efforts at reducing cadmium exposures, mainly through tobacco smoking cessation programs, may decrease the incidence of depression. C1 [Scinicariello, F.; Buser, M. C.] ATSDR, Div Toxicol & Human Hlth Sci, Atlanta, GA USA. RP Scinicariello, F (reprint author), Ctr Dis Control & Prevent, ATSDR, 4770 Buford Hwy,MS F57, Atlanta, GA 30341 USA. EM fes6@cdc.gov FU CDC FX This research was supported in part by an appointment to the Research Participation Program at the CDC administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and CDC (M.C.B.). The findings and conclusions in this report are those of the authors and do not necessarily represent the views of CDC/ATSDR. NR 43 TC 6 Z9 6 U1 1 U2 5 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0033-2917 EI 1469-8978 J9 PSYCHOL MED JI Psychol. Med. PD MAR PY 2015 VL 45 IS 4 BP 807 EP 815 DI 10.1017/S0033291714001883 PG 9 WC Psychology, Clinical; Psychiatry; Psychology SC Psychology; Psychiatry GA CB4SR UT WOS:000349618900012 PM 25115444 ER PT J AU Gelting, RJ Baloch, MA Zarate-Bermudez, M Hajmeer, MN Yee, JC Brown, T Yee, BJ AF Gelting, Richard J. Baloch, Mansoor A. Zarate-Bermudez, Max Hajmeer, Maha N. Yee, J. Christopher Brown, Teresa Yee, Benson J. TI A systems analysis of irrigation water quality in an environmental assessment of an E. coli 0157:H7 outbreak in the United States linked to iceberg lettuce SO AGRICULTURAL WATER MANAGEMENT LA English DT Article ID ENTERICA SEROVAR TYPHIMURIUM; ESCHERICHIA-COLI; BOVINE MANURE; FRESH PRODUCE; LEAF LETTUCE; CONTAMINATED MANURE; ANIMAL WASTE; O157-H7; SURVIVAL; O157H7 AB A foodborne Escherichia coli 0157:H7 outbreak in December 2006 included 77 illnesses reported in Iowa and Minnesota. Epidemiologic investigations by health departments in those states and the U.S. Centers for Disease Control and Prevention (CDC) identified shredded iceberg lettuce (Lactuca sativa L) as the vehicle of transmission. The U.S. Food and Drug Administration (FDA) and Minnesota and California public health agencies traced the lettuce to several growing regions in California based on information from a lettuce processor in Minnesota. Samples from an environmental investigation initiated by the California Food Emergency Response Team (CalFERT) revealed a genetic match between the outbreak strain and environmental samples from a single farm, leading to an in-depth systems-based analysis of the irrigation water system on that farm. This paper presents findings from that systems-based analysis, which assessed conditions on the farm potentially contributing to contamination of the lettuce. The farm had three sources of irrigation water: groundwater from onsite wells, surface water delivered by a water management agency and effluent from wastewater lagoons on nearby dairy farms. Wastewater effluent was blended with the other sources and used only to irrigate animal feed crops. However, water management on the farm, including control of wastewater blending, appeared to create potential for cross-contamination. Pressure gradients and lack of backflow measures in the irrigation system might have created conditions for cross-contamination of water used to irrigate lettuce. The irrigation network on the farm had evolved over time to meet various needs, without an overall analysis of how that evolution potentially created vulnerabilities to contamination,of irrigation water. The type of systems analysis described here is one method for helping to ensure that such vulnerabilities are identified and addressed. A preventive, risk-based management approach, such as the Water Safety Plan process for drinking water, may also be useful in managing irrigation water quality. Published by Elsevier B.V. C1 [Gelting, Richard J.] Ctr Dis Control & Prevent, Ctr Global Hlth, Hlth Syst Reconstruct Team, Atlanta, GA 30341 USA. [Baloch, Mansoor A.; Zarate-Bermudez, Max] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Environm Hlth Serv Branch, Atlanta, GA 30341 USA. [Hajmeer, Maha N.; Yee, Benson J.] Calif Dept Publ Hlth, Food & Drug Branch, Sacramento, CA 95899 USA. [Yee, J. Christopher] US FDA, Oakland, CA 94612 USA. [Brown, Teresa] Univ Tennessee, Dept Earth & Planetary Sci, Knoxville, TN 37996 USA. RP Gelting, RJ (reprint author), Ctr Dis Control & Prevent, Ctr Global Hlth, Hlth Syst Reconstruct Team, MS F-57, Atlanta, GA 30341 USA. EM rgelting@cdc.gov; mzaratebermudez@cdc.gov NR 55 TC 2 Z9 2 U1 3 U2 46 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3774 EI 1873-2283 J9 AGR WATER MANAGE JI Agric. Water Manage. PD MAR 1 PY 2015 VL 150 BP 111 EP 118 DI 10.1016/j.agwat.2014.12.002 PG 8 WC Agronomy; Water Resources SC Agriculture; Water Resources GA CA5NK UT WOS:000348954900011 ER PT J AU Wu, E El-Bassel, N McVinney, LD Hess, L Fopeano, MV Hwang, HG Charania, M Mansergh, G AF Wu, Elwin El-Bassel, Nabila McVinney, L. Donald Hess, Leona Fopeano, Mark V. Hwang, Hyesung G. Charania, Mahnaz Mansergh, Gordon TI The Association Between Substance Use and Intimate Partner Violence Within Black Male Same-Sex Relationships SO JOURNAL OF INTERPERSONAL VIOLENCE LA English DT Article DE substance use; partner violence; men who have sex with men; African American; Black; syndemic ID AGGRESSION REPORTING CONCORDANCE; PROBABILITY-BASED SAMPLE; ALCOHOL OUTLET DENSITY; HIV RISK BEHAVIORS; DOMESTIC VIOLENCE; LESBIAN RELATIONSHIPS; MINORITY STRESS; BISEXUAL MEN; HISPANIC COUPLES; UNITED-STATES AB Compared with the extant research on heterosexual intimate partner violence (IPV)-including the knowledge base on alcohol and illicit drug use as predictors of such IPV-there is a paucity of studies on IPV among men who have sex with men (MSM), especially Black MSM. This study investigates the prevalence of experiencing and perpetrating IPV among a sample of Black MSM couples and examines whether heavy drinking and/or illicit substance use is associated with IPV. We conducted a secondary analysis on a data set from 74 individuals (constituting 37 Black MSM couples) screened for inclusion in a couple-based HIV prevention pilot study targeting methamphetamine-involved couples. More than one third (n=28, 38%) reported IPV at some point with the current partner: 24 both experiencing and perpetrating, 2 experiencing only, and 2 perpetrating only. IPV in the past 30 days was reported by 21 (28%) of the participants: 18 both experiencing and perpetrating, 1 experiencing only, and 2 perpetrating only. Heavy drinking and methamphetamine use each was associated significantly with experiencing and perpetrating IPV throughout the relationship as well as in the past 30 days. Rock/crack cocaine use was significantly associated with any history of experiencing and perpetrating IPV. Altogether, IPV rates in this sample of Black MSM couples equal or exceed those observed among women victimized by male partners as well as the general population of MSM. This exploratory study points to a critical need for further efforts to understand and address IPV among Black MSM. Similar to heterosexual IPV, results point to alcohol and illicit drug use treatment as important avenues to improve the health and social well-being of Black MSM. C1 [Wu, Elwin; El-Bassel, Nabila] Columbia Univ, Sch Social Work, New York, NY 10027 USA. [El-Bassel, Nabila] Columbia Univ, Global Hlth Res Ctr Cent Asia, New York, NY 10027 USA. [Hess, Leona; Fopeano, Mark V.; Hwang, Hyesung G.] Columbia Univ, New York, NY 10027 USA. [McVinney, L. Donald] Harlem United, New York, NY USA. [Charania, Mahnaz; Mansergh, Gordon] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Wu, E (reprint author), Columbia Univ, Sch Social Work, Social Intervent Grp, 1255 Amsterdam Ave, New York, NY 10027 USA. EM ew157@columbia.edu FU NCHHSTP CDC HHS [UR6PS000300] NR 64 TC 3 Z9 3 U1 3 U2 9 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0886-2605 EI 1552-6518 J9 J INTERPERS VIOLENCE JI J. Interpers. Violence PD MAR PY 2015 VL 30 IS 5 BP 762 EP 781 DI 10.1177/0886260514536277 PG 20 WC Criminology & Penology; Family Studies; Psychology, Applied SC Criminology & Penology; Family Studies; Psychology GA CA1BE UT WOS:000348646900003 PM 24919997 ER PT J AU Bergman, MS He, XJ Joseph, ME Zhuang, ZQ Heimbuch, BK Shaffer, RE Choe, M Wander, JD AF Bergman, Michael S. He, Xinjian Joseph, Michael E. Zhuang, Ziqing Heimbuch, Brian K. Shaffer, Ronald E. Choe, Melanie Wander, Joseph D. TI Correlation of Respirator Fit Measured on Human Subjects and a Static Advanced Headform SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE advanced headform; filtering facepiece respirator; fit test; N95 ID PROTECTION AB This study assessed the correlation of N95 filtering face-piece respirator (FFR) fit between a Static Advanced Headform (StAH) and 10 human test subjects. Quantitative fit evaluations were performed on test subjects who made three visits to the laboratory. On each visit, one fit evaluation was performed on eight different FFRs of various model/size variations. Additionally, subject breathing patterns were recorded. Each fit evaluation comprised three two-minute exercises: "Normal Breathing," "Deep Breathing," and again "Normal Breathing." The overall test fit factors (FF) for human tests were recorded. The same respirator samples were later mounted on the StAH and the overall test manikin fit factors (MFF) were assessed utilizing the recorded human breathing patterns. Linear regression was performed on the mean log(10)-transformed FF and MFF values to assess the relationship between the values obtained from humans and the StAH. This is the first study to report a positive correlation of respirator fit between a headform and test subjects. The linear regression by respirator resulted in R-2 = 0.95, indicating a strong linear correlation between FF and MFF. For all respirators the geometric mean (GM) FF values were consistently higher than those of the GM MFF. For 50% of respirators, GM FF and GM MFF values were significantly different between humans and the StAH. For data grouped by subject/respirator combinations, the linear regression resulted in R-2 = 0.49. A weaker correlation (R-2 = 0.11) was found using only data paired by subject/respirator combination where both the test subject and StAH had passed a real-time leak check before performing the fit evaluation. For six respirators, the difference in passing rates between the StAH and humans was < 20%, while two respirators showed a difference of 29% and 43%. For data by test subject, GM FF and GM MFF values were significantly different for 40% of the subjects. Overall, the advanced headform system has potential for assessing fit for some N95 FFR model/sizes. C1 [Bergman, Michael S.; He, Xinjian; Joseph, Michael E.; Zhuang, Ziqing; Shaffer, Ronald E.] NIOSH, Natl Personal Protect Technol Lab, Pittsburgh, PA 15236 USA. [Heimbuch, Brian K.] Appl Res Associates Inc, Panama City, FL USA. [Choe, Melanie] US Dept HHS, Off Assistant Secretary Preparedness & Response, Biomed Adv Res & Dev Author, Washington, DC 20201 USA. [Wander, Joseph D.] Air Force Civil Engineer Ctr, Tyndall AFB, FL USA. [He, Xinjian] W Virginia Univ, Dept Ind & Management Syst Engn, Morgantown, WV 26506 USA. RP Zhuang, ZQ (reprint author), NIOSH, Technol Res Branch, Natl Personal Protect Technol Lab, Ctr Dis Control & Prevent, 626 Cochrans Mill Rd,Bldg 29,POB 18070, Pittsburgh, PA 15236 USA. EM zaz3@cdc.gov FU U.S. Department of Health and Human Services (HHS); Office of Assistant Secretary for Preparedness and Response, Biomedical Advanced Research and Development Authority (BARDA); Air Force Research Laboratory (AFRL) FX This research was funded by the U.S. Department of Health and Human Services (HHS), the Office of Assistant Secretary for Preparedness and Response, Biomedical Advanced Research and Development Authority (BARDA) through an interagency agreement with the Air Force Research Laboratory (AFRL). NR 12 TC 0 Z9 0 U1 1 U2 10 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PD MAR PY 2015 VL 12 IS 3 BP 163 EP 171 DI 10.1080/15459624.2014.957832 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA CA7NT UT WOS:000349104900005 PM 25265037 ER PT J AU Noll, J Gilles, S Wu, HW Rubinstein, E AF Noll, James Gilles, Stewart Wu, Hsin Wei Rubinstein, Elaine TI The Relationship Between Elemental Carbon and Diesel Particulate Matter in Underground Metal/Nonmetal Mines in the United States and Coal Mines in Australia SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE diesel; elemental carbon; measurement ID CASSETTE AB In the United States, total carbon (TC) is used as a surrogate for determining diesel particulate matter (DPM) compliance exposures in underground metal/nonmetal mines. Since TC can be affected by interferences and elemental carbon (EC) is not, one method used to estimate the TC concentration is to multiply the EC concentration from the personal sample by a conversion factor to avoid the influence of potential interferences. Since there is no accepted single conversion factor for all metal/nonmetal mines, one is determined every time an exposure sample is taken by collecting an area sample that represents the TC/EC ratio in the miner's breathing zone and is away from potential interferences. As an alternative to this procedure, this article investigates the relationship between TC and EC from DPM samples to determine if a single conversion factor can be used for all metal/nonmetal mines. In addition, this article also investigates how well EC represents DPM concentrations in Australian coal mines since the recommended exposure limit for DPM in Australia is an EC value. When TC was predicted from EC values using a single conversion factor of 1.27 in 14 US metal/nonmetal mines, 95% of the predicted values were within 18% of the measured value, even at the permissible exposure limit (PEL) concentration of 160 mu g/m(3) TC. A strong correlation between TC and EC was also found in nine underground coal mines in Australia. C1 [Noll, James; Rubinstein, Elaine] NIOSH, Dust Ventilat & Tox Subst Branch, US Dept HHS,Publ Hlth Serv, Ctr Dis Control & Prevent,Pittsburgh Res Lab, Pittsburgh, PA 15236 USA. [Gilles, Stewart] Missouri Univ Sci & Technol, Rolla, MO USA. [Wu, Hsin Wei] Gilles Wu Min Technol Pty Ltd, Brisbane, Qld, Australia. RP Noll, J (reprint author), NIOSH, US Dept HHS, Publ Hlth Serv, Ctr Dis Control & Prevent,Pittsburgh Res Lab, 626 Cochrans Mill Rd, Pittsburgh, PA 15236 USA. EM jnoll@cdc.gov FU Intramural CDC HHS [CC999999] NR 20 TC 2 Z9 2 U1 2 U2 6 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PD MAR PY 2015 VL 12 IS 3 BP 205 EP 211 DI 10.1080/15459624.2014.960577 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA CA7NT UT WOS:000349104900010 PM 25380085 ER PT J AU Luo, H Sotnikov, S McLees, A Stokes, S AF Luo, Huabin Sotnikov, Sergey McLees, Anita Stokes, Shereitte TI Factors Driving the Adoption of Quality Improvement Initiatives in Local Health Departments: Results From the 2010 Profile Study SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE determinants; local health departments; quality improvement ID PUBLIC-HEALTH; ENVIRONMENTAL-FACTORS; NATIONAL PROFILE; ACCREDITATION; PERFORMANCE; MANAGEMENT; SYSTEM; STATES; DETERMINANTS; EXPERIENCE AB Background: Over the past decade, quality improvement (QI) has become a major focus in advancing the goal of improving performance of local health departments (LHDs). However, limited empirical data exists on the current implementation of QI initiatives in LHDs and factors associated with adoption of QI initiatives. Objectives: (1) To examine the current implementation of QI implementation initiatives by LHDs and (2) to identify factors contributing to LHDs' decision to implement QI initiatives. Methods: In this study, a novel theoretical framework based on analysis of QI in medicine was applied to analyze QI by LHDs. LHDs' QI adoption was assessed by the number of formal QI projects reported by LHDs that responded to module 1 of the 2010 National Profile of Local Health Department Study (Profile Study) conducted by the National Association of County & City Health Officials. The Profile Study data were merged with data from the Health Resources and Services Administration's Area Resource Files and the Association of State and Territorial Health Officials' 2010 Survey. Logistic regression analyses were conducted using Stata 11 SVY procedure to account for the complex sampling design. Results: The Profile Study data indicated that about 73% of the LHDs reported implementing 1 or more QI projects. LHDs with large jurisdiction population (>50 000), higher per capita public health expenditure, a designated QI staff member, or prior participation in performance improvement programs were more likely to have undertaken QI initiatives. Conclusion: According to the Profile Study, more than a quarter of LHDs surveyed did not report implementing any formal QI projects. Greater investments in QI programs and designation of QI staff can be effective strategies to promote QI adoption. The validity of the definition of a formal QI project needs to be established. More research to identify the barriers to successful QI implementation at LHDs is also needed. C1 [Luo, Huabin] E Carolina Univ, Brody Sch Med, Dept Publ Hlth, Greenville, NC 27834 USA. [Sotnikov, Sergey; McLees, Anita; Stokes, Shereitte] Ctr Dis Control & Prevent, Off State Tribal Local & Terr Support, Atlanta, GA USA. RP Luo, H (reprint author), E Carolina Univ, Brody Sch Med, Dept Publ Hlth, Greenville, NC 27834 USA. EM luoh@ecu.edu FU Intramural CDC HHS [CC999999] NR 39 TC 3 Z9 3 U1 6 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD MAR-APR PY 2015 VL 21 IS 2 BP 176 EP 185 DI 10.1097/PHH.0000000000000113 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CA3TQ UT WOS:000348829900012 PM 24978615 ER PT J AU Lorick, SA Goldberg, L Zhang, F Birkhimer, N Dube, N Dutram, K Hubley, T Tipton, M Basurto-Davila, R Graitcer, S Mills, DA AF Lorick, Suchita A. Goldberg, Lisa Zhang, Fan Birkhimer, Nancy Dube, Nancy Dutram, Kay Hubley, Teresa Tipton, Meredith Basurto-Davila, Ricardo Graitcer, Sam Mills, Dora Anne TI Factors Associated With Uptake of the Influenza A(H1N1)pdm09 Monovalent Pandemic Vaccine in K-12 Public Schools, Maine 2009-2010 SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE H1N1; pandemic; influenza; school clinic; vaccination ID A H1N1 MONOVALENT; PROMISING PRACTICES; SEASONAL INFLUENZA; CLINICS; IMMUNIZATION; EXPERIENCE; CHILDREN; PROGRAM; SYSTEM; COSTS AB Context and Objective: Maine implemented a statewide pre-K through 12-school vaccination program during the 2009-2010 H1N1 influenza pandemic. The main objective of this study was to determine which school, nurse, consent form, and clinic factors were associated with school-level vaccination rates for the first dose of the 2009 H1N1 pandemic vaccine. Methods: In April 2010, school nurses or contacts were e-mailed electronic surveys. Generalized linear mixed regression was used to predict adjusted vaccination rates using random effects to account for correlations within school districts. Elementary and secondary (middle and high) schools were analyzed separately. Results: Of 645 schools invited to participate, 82% (n = 531) completed the survey. After excluding schools that were ineligible or could not provide outcome data, data for 256 elementary and 124 secondary public schools were analyzed and included in the multivariable analyses. The overall, unadjusted, vaccination rate was 51% for elementary schools and 45% for secondary schools. Elementary schools that had 50 or fewer students per grade, had availability of additional nursing staff, which did not require parental presence at the H1N1 clinic or disseminated consent forms by mail and backpack (compared with backpack only) had statistically significant (P < .05) higher (adjusted) vaccination rates. For secondary schools, the vaccination rate for schools with the lowest proportion of students receiving subsidized lunch (ie, highest socioeconomic status) was 58% compared with 37% (P < .001) for schools with the highest proportion receiving subsidized lunch. Conclusions: Several factors were independently associated with vaccination rates. For elementary schools, planners should consider strategies such as providing additional nursing staff and disseminating consent forms via multiple methods. The impact of additional factors, including communication approaches and parent and student attitudes, needs to be investigated, especially for secondary schools. C1 [Lorick, Suchita A.; Zhang, Fan; Graitcer, Sam] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Goldberg, Lisa] Alameda Cty Publ Hlth Dept, Oakland, CA USA. [Birkhimer, Nancy] Maine Ctr Dis Control & Prevent, Maine Dept Hlth & Human Serv, Augusta, ME USA. [Dube, Nancy] Maine Dept Educ, Augusta, ME USA. [Dutram, Kay] Univ Arkansas, Pine Bluff, AR USA. [Hubley, Teresa] Molina Medicaid Solut, Baton Rogue, LA USA. [Tipton, Meredith] Tipton Enterprizes Inc, South Portland, ME USA. [Basurto-Davila, Ricardo] Los Angeles Cty Dept Publ Hlth, Los Angeles, CA USA. [Mills, Dora Anne] Univ New England, Portland, ME USA. RP Lorick, SA (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,NE,MS A19, Atlanta, GA 30333 USA. EM dvl7@cdc.gov NR 21 TC 1 Z9 1 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD MAR-APR PY 2015 VL 21 IS 2 BP 186 EP 195 DI 10.1097/PHH.0000000000000156 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CA3TQ UT WOS:000348829900013 PM 25303864 ER PT J AU Adekoya, N Truman, BI Ajani, UA AF Adekoya, Nelson Truman, Benedict I. Ajani, Umed A. TI Completeness of Reporting of Race and Ethnicity Data in the Nationally Notifiable Diseases Surveillance System, United States, 2006-2010 SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE completion rate; ethnic groups; NNDSS; race ID DISPARITIES; INFECTIONS AB Context: During 1994-1997, approximately 70% and 60% of the cases of conditions reported to the National Notifiable Diseases Surveillance System included persons of known race and ethnicity, respectively. A major goal of the Healthy People 2020 initiative is to eliminate health disparities. Objective: To describe trends in the completeness of race and ethnicity in case reports of the National Notifiable Diseases Surveillance System during 2006-2010. Methods: The National Notifiable Diseases Surveillance System is a public health surveillance system that aggregates case reports of infectious diseases and conditions that are designated nationally notifiable and are collected by US states and territories. The Centers for Disease Control and Prevention (Atlanta, Georgia) maintains this surveillance system in collaboration with the Council of State and Territorial Epidemiologists. We used Cochran-Armitage Trend Test (SAS, version 9.2) to test the hypothesis that the percentage of case reports with the completeness of race and ethnicity data increased or decreased linearly during 2006-2010. Main Outcome Measure: Completeness of race and ethnicity variables. Results: The 32 conditions reviewed included 1 030 804 case records. Seventy percent of records included a known value for race, and 49% of records included ethnicity during 2006-2010. During 2006-2010, race was known in 70% or more of records in 24 of 32 conditions and in 23 of 51 jurisdictions. During 2006-2010, the systemwide reporting of race remained at the same level of completeness (70%) but the reporting of ethnicity increased slightly from 48% in 2006 to 53% in 2010. In comparison with race, the proportions of records coded to ethnicity were less among all conditions. Conclusions: Significant change has occurred in the completeness of reporting of ethnicity but not race during 2006-2010. However, the reporting of ethnicity still lags substantially behind the reporting of race. Jurisdictions that identify conditions with lower rates of completeness of race and ethnicity can assess the net benefits of efforts to improve the completeness of race and ethnicity data. C1 [Adekoya, Nelson; Ajani, Umed A.] Ctr Dis Control & Prevent, Div Hlth Informat & Surveillance, Ctr Surveillance, Epidemiol & Lab Serv,Off Publ Hlth Sci Serv, Atlanta, GA USA. Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Off Director, Atlanta, GA USA. RP Adekoya, N (reprint author), Ctr Surveillance, Epidemiol & Lab Serv, Off Publ Hlth Sci Serv, 1600 Clifton Rd,NE,MS-E91, Atlanta, GA 30333 USA. EM nba7@cdc.gov FU Intramural CDC HHS [CC999999] NR 27 TC 1 Z9 1 U1 2 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD MAR-APR PY 2015 VL 21 IS 2 BP E16 EP E22 DI 10.1097/PHH.0000000000000075 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CA3TQ UT WOS:000348829900003 PM 24777058 ER PT J AU Miller, DB O'Callaghan, JP AF Miller, Diane B. O'Callaghan, James P. TI Biomarkers of Parkinson's disease: Present and future SO METABOLISM-CLINICAL AND EXPERIMENTAL LA English DT Article DE Imaging; Fluid biomarkers; alpha-Synuclein; Transcranial sonography ID CEREBROSPINAL-FLUID BIOMARKERS; ALPHA-SYNUCLEIN; NEURODEGENERATIVE DISORDERS; BLOOD BIOMARKERS; PROGRESSION; TRIALS; DIAGNOSIS; EXPOSOME; CRITERIA; UPDATE AB Sporadic or idiopathic Parkinson's disease (PD) is an age-related neurodegenerative disorder of unknown origin that ranks only second behind Alzheimer's disease (AD) in prevalence and its consequent social and economic burden. PD neuropathology is characterized by a selective loss of dopaminergic neurons in the substantia nigra pars compacta; however, more widespread involvement of other CNS structures and peripheral tissues now is widely documented. The onset of molecular and cellular neuropathology of PD likely occurs decades before the onset of the motor symptoms characteristic of PD. The hallmark symptoms of PD, resting tremors, rigidity and postural disabilities, are related to dopamine (DA) deficiency. Current therapies treat these symptoms by replacing or boosting existing DA. All current interventions have limited therapeutic benefit for disease progression because damage likely has progressed over an estimated period of similar to 5 to 15 years to a loss of 60%-80% of the nigral DA neurons, before symptoms emerge. There is no accepted definitive biomarker of PD. An urgent need exists to develop early diagnostic biomarkers for two reasons: (1) to intervene at the onset of disease and (2) to monitor the progress of therapeutic interventions that may slow or stop the course of the disease. In the context of disease development, one of the promises of personalized medicine is the ability to predict, on an individual basis, factors contributing to the susceptibility for the development of a given disease. Recent advances in our understanding of genetic factors underlying or contributing to PD offer the potential for monitoring susceptibility biomarkers that can be used to identify at-risk individuals and possibly prevent the onset of disease through treatment. Finally, the exposome concept is new in the biomarker discovery arena and it is suggested as a way to move forward in identifying biomarkers of neurological diseases. It is a two-stage scheme involving a first stage of exposome-wide association studies (EWAS) to profile omic features in serum to discover molecular biomarkers. The second stage involves application of this knowledge base in follow-up studies. This strategy is unique in that it promotes the use of data-driven (omic) strategies in interrogating diseased and healthy populations and encourages a movement away from using only reductionist strategies to discover biomarkers of exposure and disease. In this short review we will examine 1) advances in our understanding of the molecular mechanisms underlying PD that have led to candidate biomarkers for diagnosis and treatment efficacy and 2) new technologies on the horizon that will lead to novel approaches in biomarker development. Published by Elsevier Inc. C1 [Miller, Diane B.; O'Callaghan, James P.] Natl Inst Occupat Safety & Hlth, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. RP Miller, DB (reprint author), CDC NIOSH, TMBB HELD, Hlth Effects Lab Div, Mailstop L-3014,1095 Willowdale Rd, Morgantown, WV 26505 USA. EM dum6@cdc.gov; jdo5@cdc.gov FU Intramural CDC HHS [CC999999] NR 58 TC 26 Z9 27 U1 5 U2 58 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0026-0495 EI 1532-8600 J9 METABOLISM JI Metab.-Clin. Exp. PD MAR PY 2015 VL 64 IS 3 SU 1 BP S40 EP S46 DI 10.1016/j.metabol.2014.10.030 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA CA2QP UT WOS:000348752800008 PM 25510818 ER PT J AU Dave, D Decker, SL Kaestner, R Simon, KI AF Dave, Dhaval Decker, Sandra L. Kaestner, Robert Simon, Kosali I. TI THE EFFECT OF MEDICAID EXPANSIONS IN THE LATE 1980S AND EARLY 1990S ON THE LABOR SUPPLY OF PREGNANT WOMEN SO AMERICAN JOURNAL OF HEALTH ECONOMICS LA English DT Article DE Medicaid; labor supply; pregnant women ID HEALTH-INSURANCE COVERAGE; WELFARE PARTICIPATION; PRIVATE INSURANCE; EMPLOYMENT; CHILDREN; PROGRAM; CROWD; ELIGIBILITY; VARIABLES; IMPACT AB A substantial body of research has found that expansions in Medicaid eligibility increased enrollment in Medicaid, reduced the rate of uninsured, and reduced the rate of private health insurance coverage (i.e., crowd-out). Notably, no published research has examined the labor supply mechanism by which crowd-out could occur. This study examines the effects of expansions in Medicaid eligibility for pregnant women in the late 1980s and the early 1990s on labor supply, which is one of the possible mechanisms underlying crowd-out. Estimates suggest that the 20 percentage point increase in Medicaid eligibility during the sample period was associated with an 11-13 percent decrease in the probability that a woman who gave birth in the past year was employed. Among unmarried women with less than a high school education, the change in Medicaid eligibility reduced employment by approximately 13 percent to 16 percent. We find that most of this reduction in labor supply was associated with crowd-out (i.e., movement from private to public insurance concurrent with the shift in labor supply). C1 [Dave, Dhaval] Bentley Univ, Dept Econ, Waltham, MA USA. [Dave, Dhaval; Kaestner, Robert; Simon, Kosali I.] NBER, Cambridge, MA 02138 USA. [Decker, Sandra L.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Atlanta, GA 30333 USA. [Kaestner, Robert] Univ Illinois, Dept Econ, Chicago, IL 60680 USA. [Simon, Kosali I.] Indiana Univ, Sch Environm & Publ Affairs, Bloomington, IN 47405 USA. RP Decker, SL (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Atlanta, GA 30333 USA. EM sdecker@cdc.gov NR 38 TC 3 Z9 3 U1 0 U2 0 PU MIT PRESS PI CAMBRIDGE PA ONE ROGERS ST, CAMBRIDGE, MA 02142-1209 USA SN 2332-3493 EI 2332-3507 J9 AM J HEALTH ECON JI AM. J. HEALTH ECON. PD SPR PY 2015 VL 1 IS 2 BP 165 EP 193 DI 10.1162/ajhe_a_00011 PG 29 WC Economics; Health Policy & Services SC Business & Economics; Health Care Sciences & Services GA DS1OT UT WOS:000380366500002 ER PT J AU Charleston, AE Wilson, HR Edwards, PO David, F Dewitt, S AF Charleston, Alex E. Wilson, Holly R. Edwards, Peter O. David, Felicita Dewitt, Shannon TI Environmental Public Health Tracking: Driving Environmental Health Information SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE public health; surveillance; environmental health; informatics ID INTERNET; SURVEILLANCE; SYSTEMS AB Context: Historically, public health professionals lacked the capacity to evaluate and conduct key investigations into the health of their environment. By bringing together environmental and health effects data from a variety of data sources, the National Environmental Public Health Tracking Network (Tracking) allows users to easily analyze and research the relationships between human health and the environment. Objective: As the Tracking Network has matured, its information has been used to guide public health actions, generate hypothesis, and demonstrate relationships between environment and health outcomes. Participants: The Tracking Network is composed of state, local, and national environment and public health partners. Settings: The Environmental Public Health Tracking Network is part of the National Center for Environmental Health at the Centers for Disease Control and Prevention. Design: Tracking standardizes existing data from diverse sources while leveraging technologies and applying sound communication practices to provide a user-friendly interface for the data system by all types of users. C1 [Charleston, Alex E.] Natl Ctr Environm Hlth, Atlanta, GA USA. [Wilson, Holly R.; Edwards, Peter O.; David, Felicita; Dewitt, Shannon] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. RP Charleston, AE (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, 4770 Buford Highway,MS F-60, Atlanta, GA 30341 USA. EM aac4@cdc.gov FU Intramural CDC HHS [CC999999] NR 21 TC 2 Z9 2 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD MAR-APR PY 2015 VL 21 SU 2 SI SI BP S4 EP S11 DI 10.1097/PHH.0000000000000173 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DI7VJ UT WOS:000373709800002 PM 25621444 ER PT J AU Kearney, GD Namulanda, G Qualters, JR Talbott, EO AF Kearney, Gregory D. Namulanda, Gonza Qualters, Judith R. Talbott, Evelyn O. TI A Decade of Environmental Public Health Tracking (2002-2012): Progress and Challenges SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE exposure; environmental health; surveillance; epidemiology ID EMERGENCY-DEPARTMENT VISITS; NEW-YORK-STATE; AMBIENT AIR-POLLUTANTS; CASE-CROSSOVER ANALYSIS; FOR-DISEASE-CONTROL; HOSPITAL ADMISSIONS; CARBON-MONOXIDE; SURVEILLANCE; POLLUTION; EXPOSURE AB Background: The creation of the Centers for Disease Control and Prevention Environmental Public Health Tracking Program spawned an invigorating and challenging approach toward implementing the nation's first population-based, environmental disease tracking surveillance system. More than 10 years have passed since its creation and an abundance of peer-reviewed articles have been published spanning a broad variety of public health topics related primarily to the goal of reducing diseases of environmental origin. Objective: To evaluate peer-reviewed literature related to Environmental Public Health Tracking during 2002-2012, recognize major milestones and challenges, and offer recommendations. Design: A narrative overview was conducted using titles and abstracts of peer-reviewed articles, key word searches, and science-based search engine databases. Main Outcomes: Eighty published articles related to "health tracking" were identified and categorized according to 4 crossed-central themes. The Science and Research theme accounted for the majority of published articles, followed by Policy and Practice, Collaborations Among Health and Environmental Programs, and Network Development. Conclusions: Overall, progress was reported in the areas of data linkage, data sharing, surveillance methods, and network development. Ongoing challenges included formulating better ways to establish the connections between health and the environment, such as using biomonitoring, public water systems, and private well water data. Recommendations for future efforts include use of data to inform policy and practice and use of electronic health records data for environmental health surveillance. C1 [Kearney, Gregory D.] E Carolina Univ, Dept Publ Hlth, Brody Sch Med, 600 Moye Blvd,MS 660,Lakeside Annex 8, Greenville, NC 27834 USA. [Namulanda, Gonza; Qualters, Judith R.] Ctr Dis Control & Prevent, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Atlanta, GA USA. [Talbott, Evelyn O.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA. RP Kearney, GD (reprint author), E Carolina Univ, Dept Publ Hlth, Brody Sch Med, 600 Moye Blvd,MS 660,Lakeside Annex 8, Greenville, NC 27834 USA. EM kearneyg@ecu.edu OI Talbott, Evelyn/0000-0002-5198-7939 NR 86 TC 1 Z9 1 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD MAR-APR PY 2015 VL 21 SU 2 SI SI BP S23 EP S35 DI 10.1097/PHH.0000000000000181 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DI7VJ UT WOS:000373709800004 PM 25621442 ER PT J AU Qualters, JR Strosnider, HM Bell, R AF Qualters, Judith R. Strosnider, Heather M. Bell, Rosalyn TI Data to Action: Using Environmental Public Health Tracking to Inform Decision Making SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE environmental public health tracking; environmental public health actions; information system integration; surveillance system; environmental monitoring; environmental public health surveillance ID CARBON-MONOXIDE; SURVEILLANCE; SYSTEM AB Context: Public health surveillance includes dissemination of data and information to those who need it to take action to prevent or control disease. The concept of data to action is explicit in the mission of the Centers for Disease Control and Prevention's (CDC's) National Environmental Public Health Tracking Program (Tracking Program). The CDC has built a National Environmental Public Health Tracking Network (Tracking Network) to integrate health and environmental data to drive public health action (PHA) to improve communities' health. Objective: To assess the utility of the Tracking Program and Tracking Network in environmental public health practice and policy making. Design: We analyzed information on how Tracking (all program components hereafter referred to generally as "Tracking") has been used to drive PHAs within funded states and cities (grantees). Two case studies are presented to highlight Tracking's utility. Setting: Analyses included all grantees funded between 2005 and 2013. Participants: Twenty-seven states, 3 cities, and the District of Columbia ever received funding. Main Outcome Measures: We categorized each PHA reported to determine how grantees became involved, their role, the problems addressed, and the overall action. Results: Tracking grantees reported 178 PHAs from 2006 to 2013. The most common overall action was "provided information in response to concern" (n = 42), followed by "improved a public health program, intervention, or response plan" (n = 35). Tracking's role was most often either to enhance surveillance (24%) or to analyze data (23%). In 47% of PHAs, the underlying problem was a concern about possible elevated rates of a health outcome, a potential exposure, or a potential association between a hazard and a health outcome. PHAs were started by a request for assistance (48%), in response to an emergency (8%), and though routine work by Tracking programs (43%). Conclusion: Our review shows that the data, expertise, technical infrastructure, and other resources of the Tracking Program and Tracking Network are driving state and local PHAs. C1 [Qualters, Judith R.; Strosnider, Heather M.; Bell, Rosalyn] Ctr Dis Control & Prevent, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Off Noninfect Dis Injury & Environm Hlth, 4770 Buford Hwy NE,MS F60, Atlanta, GA 30341 USA. RP Qualters, JR (reprint author), Ctr Dis Control & Prevent, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Off Noninfect Dis Injury & Environm Hlth, 4770 Buford Hwy NE,MS F60, Atlanta, GA 30341 USA. EM jqualters@cdc.gov FU Environmental Public Health Tracking Program from the Centers for Disease Control and Prevention (CDC) FX This article was supported by the Environmental Public Health Tracking Program from the Centers for Disease Control and Prevention (CDC). The contents of this article are solely the responsibility of the authors and do not necessarily represent the official views of the CDC. NR 25 TC 2 Z9 2 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD MAR-APR PY 2015 VL 21 SU 2 SI SI BP S12 EP S22 DI 10.1097/PHH.0000000000000175 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DI7VJ UT WOS:000373709800003 PM 25621441 ER PT J AU Qualters, JR AF Qualters, Judith R. TI Fulfilling the Vision of Environmental Public Health Tracking SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Editorial Material C1 [Qualters, Judith R.] Ctr Dis Control & Prevent, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Off Noninfect Dis Injury & Environm Hlth, 4770 Buford Highway,MS F-60, Atlanta, GA 30341 USA. RP Qualters, JR (reprint author), Ctr Dis Control & Prevent, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Off Noninfect Dis Injury & Environm Hlth, 4770 Buford Highway,MS F-60, Atlanta, GA 30341 USA. EM jqualters@cdc.gov NR 19 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD MAR-APR PY 2015 VL 21 SU 2 SI SI BP S1 EP S3 DI 10.1097/PHH.0000000000000148 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DI7VJ UT WOS:000373709800001 PM 25621439 ER PT J AU Wall, P Kassinger, C AF Wall, Patrick Kassinger, Craig TI Multiple Measures on the Environmental Public Health Tracking Network SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE public health surveillance systems; informatics; information systems; environmental health; data display; health information systems; health data AB Setting: The Centers for Disease Control and Prevention's National Environmental Public Health Tracking Program is leading an initiative to build a National Environmental Public Health Tracking Network (Tracking Network) that integrates data into a network of standardized electronic data to provide valid scientific information on environmental exposures and adverse health conditions, as well as spatial and temporal relations between them. The Web-based Tracking Network is designed for different audiences including government, the academic community, and the public. A primary goal of the Tracking Network is to allow the exploration of data on health effects, environments, and demographics. The wide variety of data types along with stratifications present a complex problem when developing system functionality to query and display disparate data simultaneously in a comparable way using charts, tables, and maps. Objective: While the ability to query and display data that span across geographies and multiple time periods for a single type of data has been the main feature set of the Tracking Network, allowing the same for multiple data types is needed to enable users to explore trends and possible associations among health and environmental data. Methods: As a first step, a multidisciplinary team was formed to address complex issues related to developing the ability to view multiple measures on the Tracking Network. The team then iterated through steps involving requirements gathering, the segmentation of the requirements into functional areas, submission of proposals to address those functional areas, and finally evaluation of the proposals to address functional areas. Conclusions: Adding the ability to view multiple measures is an important step to improve Tracking Network users' exploration of the environmental health status of their communities. With this capability, public health practitioners and other users can formulate hypotheses, analyze trends, and explore possible relationships across a wide variety of environmental and health information. C1 [Wall, Patrick; Kassinger, Craig] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, 4770 Buford Hwy NE,M-S F-60, Atlanta, GA 30341 USA. RP Wall, P (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, 4770 Buford Hwy NE,M-S F-60, Atlanta, GA 30341 USA. EM pwall@cdc.gov NR 10 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD MAR-APR PY 2015 VL 21 SU 2 SI SI BP S36 EP S43 DI 10.1097/PHH.0000000000000185 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DI7VJ UT WOS:000373709800005 PM 25621443 ER PT J AU Aoyagi, KL Brooks, BD Bearden, SW Montenieri, JA Gage, KL Fisher, MA AF Aoyagi, Kari L. Brooks, Benjamin D. Bearden, Scott W. Montenieri, John A. Gage, Kenneth L. Fisher, Mark A. TI LPS modification promotes maintenance of Yersinia pestis in fleas SO MICROBIOLOGY-SGM LA English DT Article ID ENTEROBACTERIAL COMMON ANTIGEN; SIGNATURE-TAGGED MUTAGENESIS; EARLY-PHASE TRANSMISSION; ENTERICA SEROVAR TYPHIMURIUM; POLYMYXIN-B RESISTANCE; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA; MURINE TOXIN; ANTIMICROBIAL PEPTIDES; CAENORHABDITIS-ELEGANS AB Yersinia pestis, the causative agent of plague, can be transmitted by fleas by two different mechanisms: by early-phase transmission (EPT), which occurs shortly after flea infection, or by blocked fleas following long-term infection. Efficient flea-borne transmission is predicated upon the ability of Y. pestis to be maintained within the flea. Signature-tagged mutagenesis (STM) was used to identify genes required for Y. pestis maintenance in a genuine plague vector, Xenopsylla cheopis. The STM screen identified seven mutants that displayed markedly reduced fitness in fleas after 4 days, the time during which EPT occurs. Two of the mutants contained insertions in genes encoding glucose 1-phosphate uridylyltransferase (galU) and UDP-4-amino-4-deoxy-L-arabinose-oxoglutarate aminotransferase (arnB), which are involved in the modification of lipid A with 4-amino-4-deoxy-L-arabinose (Ara4N) and resistance to cationic antimicrobial peptides (CAMPs). These Y. pestis mutants were more susceptible to the CAMPs cecropin A and polymyxin B, and produced lipid A lacking Ara4N modifications. Surprisingly, an in-frame deletion of arnB retained modest levels of CAMP resistance and Ara4N modification, indicating the presence of compensatory factors. It was determined that WecE, an aminotransferase involved in biosynthesis of enterobacterial common antigen, plays a novel role in Y. pestis Ara4N modification by partially offsetting the loss of arnB. These results indicated that mechanisms of Ara4N modification of lipid A are more complex than previously thought, and these modifications, as well as several factors yet to be elucidated, play an important role in early survival and transmission of Y. pestis in the flea vector. C1 [Aoyagi, Kari L.; Brooks, Benjamin D.; Fisher, Mark A.] Univ Utah, Dept Pathol, 2100 JMRB,15 North Med Dr East, Salt Lake City, UT 84132 USA. [Bearden, Scott W.; Montenieri, John A.; Gage, Kenneth L.] Ctr Dis Control & Prevent, Bacterial Dis Branch, Div Vector Borne Dis, Ft Collins, CO 80521 USA. [Fisher, Mark A.] ARUP Inst Clin & Expt Pathol, Salt Lake City, UT 84108 USA. RP Fisher, MA (reprint author), Univ Utah, Dept Pathol, 2100 JMRB,15 North Med Dr East, Salt Lake City, UT 84132 USA. EM mark.fisher@path.utah.edu FU NIAID-RMRCE Career Development Award [U54 AI065357] FX We thank Phillip Nielson, Matt Cady and Patricia Getna for technical assistance, and Dr Robert Perry (University of Kentucky, Lexington, KY, USA) for providing Y. pestis KIM6+. This work was supported in part by a NIAID-RMRCE Career Development Award (U54 AI065357 to M.A.F.). NR 71 TC 4 Z9 4 U1 3 U2 8 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 1350-0872 J9 MICROBIOL-SGM JI Microbiology-(UK) PD MAR PY 2015 VL 161 BP 628 EP 638 DI 10.1099/mic.0.000018 PN 3 PG 11 WC Microbiology SC Microbiology GA DM0PJ UT WOS:000376048000015 PM 25533446 ER PT J AU Schieltz, DM McWilliams, LG Kuklenyik, Z Prezioso, SM Carter, AJ Williamson, YM McGrath, SC Morse, SA Barr, JR AF Schieltz, David M. McWilliams, Lisa G. Kuklenyik, Zsuzsanna Prezioso, Samantha M. Carter, Andrew J. Williamson, Yulanda M. McGrath, Sara C. Morse, Stephen A. Barr, John R. TI Quantification of ricin, RCA and comparison of enzymatic activity in 18 Ricinus communis cultivars by isotope dilution mass spectrometry SO TOXICON LA English DT Article DE Ricin; RCA; Ricinus communis; Cultivar; Quantification; Mass spectrometry ID RIBOSOME-INACTIVATING PROTEINS; N-GLYCOSIDASE ACTIVITY; CASTOR BEAN EXTRACTS; A-CHAIN; FORENSIC IDENTIFICATION; FUNCTIONAL RICIN; AGGLUTININ; ASSAY; RNA; SEQUENCE AB The seeds of the Ricinus communis (Castor bean) plant are the source of the economically important commodity castor oil. Castor seeds also contain the proteins ricin and R. communis agglutinin (RCA), two toxic lectins that are hazardous to human health. Radial immunodiffusion (RID) and the enzyme linked immunosorbent assay (ELISA) are two antibody-based methods commonly used to quantify ricin and RCA; however, antibodies currently used in these methods cannot distinguish between ricin and RCA due to the high sequence homology of the respective proteins. In this study, a technique combining antibody-based affinity capture with liquid chromatography and multiple reaction monitoring (MRM) mass spectrometry (MS) was used to quantify the amounts of ricin and RCA independently in extracts prepared from the seeds of eighteen representative cultivars of R. communis which were propagated under identical conditions. Additionally, liquid chromatography and MRM-MS was used to determine rRNA N-glycosidase activity for each cultivar and the overall activity in these cultivars was compared to a purified ricin standard. Of the cultivars studied, the average ricin content was 9.3 mg/g seed, the average RCA content was 9.9 mg/g seed, and the enzymatic activity agreed with the activity of a purified ricin reference within 35% relative activity. Published by Elsevier Ltd. C1 [Schieltz, David M.; McWilliams, Lisa G.; Kuklenyik, Zsuzsanna; Williamson, Yulanda M.; McGrath, Sara C.; Barr, John R.] Ctr Dis Control & Prevent, Clin Chem Branch, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Prezioso, Samantha M.; Carter, Andrew J.; Morse, Stephen A.] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. RP Barr, JR (reprint author), Ctr Dis Control & Prevent, Mailstop F-50,4770 Buford Hwy NE, Atlanta, GA 30341 USA. EM jbarr@cdc.gov OI McGrath, Sara/0000-0003-4773-4784 FU Intramural CDC HHS [CC999999] NR 75 TC 7 Z9 7 U1 0 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD MAR PY 2015 VL 95 BP 72 EP 83 DI 10.1016/j.toxicon.2015.01.003 PG 12 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA CM5SU UT WOS:000357749700011 PM 25576235 ER PT J AU Angell, SY De Cock, KM Frieden, TR AF Angell, Sonia Y. De Cock, Kevin M. Frieden, Thomas R. TI A public health approach to global management of hypertension SO LANCET LA English DT Editorial Material ID COUNTRIES; DISEASE C1 [Angell, Sonia Y.; De Cock, Kevin M.; Frieden, Thomas R.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Frieden, TR (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. EM tfrieden@cdc.gov FU Intramural CDC HHS [CC999999] NR 21 TC 13 Z9 13 U1 3 U2 8 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0140-6736 EI 1474-547X J9 LANCET JI Lancet PD FEB 28 PY 2015 VL 385 IS 9970 BP 825 EP 827 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA CC0UD UT WOS:000350051700037 PM 25752181 ER PT J AU Apostolou, A Bartholomew, ML Greeley, R Guilfoyle, SM Gordon, M Genese, C Davis, JP Montana, B Borlaug, G AF Apostolou, Andria Bartholomew, Michael L. Greeley, Rebecca Guilfoyle, Sheila M. Gordon, Marcia Genese, Carol Davis, Jeffrey P. Montana, Barbara Borlaug, Gwen TI Transmission of Hepatitis C Virus Associated with Surgical Procedures - New Jersey 2010 and Wisconsin 2011 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID GENOTYPES C1 [Apostolou, Andria; Bartholomew, Michael L.] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Apostolou, Andria; Greeley, Rebecca; Genese, Carol; Montana, Barbara] New Jersey Dept Hlth, Trenton, NJ USA. [Bartholomew, Michael L.; Guilfoyle, Sheila M.; Davis, Jeffrey P.; Borlaug, Gwen] Wisconsin Div Publ Hlth, Green Bay, WI USA. [Greeley, Rebecca] Rutgers Sch Publ Hlth, Piscataway, NJ USA. [Gordon, Marcia] Christ Hosp, Jersey City, NJ USA. RP Apostolou, A (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM andria.apostolou@ihs.gov NR 9 TC 1 Z9 1 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 27 PY 2015 VL 64 IS 7 BP 165 EP 170 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CC3BV UT WOS:000350220300001 PM 25719676 ER PT J AU David-Ferdon, C Simon, TR Spivak, H Gorman-Smith, D Savannah, SB Listenbee, RL Iskander, J AF David-Ferdon, Corinne Simon, Thomas R. Spivak, Howard Gorman-Smith, Deborah Savannah, Sheila B. Listenbee, Robert L. Iskander, John TI CDC Grand Rounds: Preventing Youth Violence SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID CHILDREN C1 [David-Ferdon, Corinne; Simon, Thomas R.] CDC, Div Violence Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA. [Gorman-Smith, Deborah] Univ Chicago, Chicago, IL 60637 USA. [Savannah, Sheila B.] Houston Dept Hlth & Human Serv, Houston, TX USA. [Listenbee, Robert L.] US Dept Justice, Off Juvenile Justice & Delinquency Prevent, Washington, DC USA. [Iskander, John] CDC, Office Director, Atlanta, GA 30333 USA. RP David-Ferdon, C (reprint author), CDC, Div Violence Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA. EM cferdon@cdc.gov NR 14 TC 6 Z9 7 U1 0 U2 4 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 27 PY 2015 VL 64 IS 7 BP 171 EP 174 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CC3BV UT WOS:000350220300002 PM 25719677 ER PT J AU Blackley, DJ Lindblade, KA Kateh, F Broyles, LN Westercamp, M Neatherlin, JC Pillai, SK Tucker, A Mott, JA Walke, H Nyenswah, T AF Blackley, David J. Lindblade, Kim A. Kateh, Francis Broyles, Laura N. Westercamp, Matthew Neatherlin, John C. Pillai, Satish K. Tucker, Anthony Mott, Joshua A. Walke, Henry Nyenswah, Tolbert TI Rapid Intervention to Reduce Ebola Transmission in a Remote Village - Gbarpolu County, Liberia, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID VIRUS DISEASE; EPIDEMIC C1 [Blackley, David J.; Westercamp, Matthew] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Lindblade, Kim A.; Mott, Joshua A.] CDC, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Broyles, Laura N.] CDC, Div Global HIV AIDS, Ctr Global Hlth, Atlanta, GA 30333 USA. [Neatherlin, John C.] CDC, Div Global Hlth Protect, Ctr Global Hlth, Atlanta, GA 30333 USA. [Pillai, Satish K.] CDC, Div Preparedness & Emerging Infect, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Walke, Henry] CDC, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. RP Blackley, DJ (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM dblackley@cdc.gov NR 5 TC 9 Z9 9 U1 0 U2 15 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 27 PY 2015 VL 64 IS 7 BP 175 EP 178 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CC3BV UT WOS:000350220300003 PM 25719678 ER PT J AU Nyenswah, T Blackley, DJ Freeman, T Lindblade, KA Arzoaquoi, SK Mott, JA Williams, JN Halldin, CN Kollie, F Laney, AS AF Nyenswah, Tolbert Blackley, David J. Freeman, Tabeh Lindblade, Kim A. Arzoaquoi, Samson K. Mott, Joshua A. Williams, Justin N. Halldin, Cara N. Kollie, Francis Laney, A. Scott TI Community Quarantine to Interrupt Ebola Virus Transmission - Mawah Village, Bong County, Liberia, August-October, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Blackley, David J.] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Freeman, Tabeh] Bong Mines Med Ctr, Bong Mines, Liberia. [Lindblade, Kim A.; Mott, Joshua A.] CDC, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Williams, Justin N.] CDC, Div Global Hlth Protect, Ctr Global Hlth, Atlanta, GA 30333 USA. [Halldin, Cara N.; Laney, A. Scott] CDC, Div Resp Dis Studies, Natl Ctr Occupat Safety & Hlth, Atlanta, GA 30333 USA. [Kollie, Francis] Fuamah Dist Hlth Team, Handii, Liberia. RP Blackley, DJ (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM dblackley@cdc.gov NR 2 TC 7 Z9 7 U1 0 U2 8 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 27 PY 2015 VL 64 IS 7 BP 179 EP 182 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CC3BV UT WOS:000350220300004 PM 25719679 ER PT J AU Hagan, JE Smith, W Pillai, SK Yeoman, K Gupta, S Neatherlin, J Slutsker, L Lindblade, KA DeCock, KM Kateh, F Nyenswah, T AF Hagan, Jose E. Smith, Wilmot Pillai, Satish K. Yeoman, Kristin Gupta, Sundeep Neatherlin, John Slutsker, Laurence Lindblade, Kim A. DeCock, Kevin M. Kateh, Francis Nyenswah, Tolbert TI Implementation of Ebola Case-Finding Using a Village Chieftaincy Taskforce in a Remote Outbreak - Liberia, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Hagan, Jose E.] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Hagan, Jose E.; Gupta, Sundeep; Neatherlin, John; Slutsker, Laurence; DeCock, Kevin M.] CDC, Ctr Global Hlth, Atlanta, GA 30333 USA. [Pillai, Satish K.; Lindblade, Kim A.] CDC, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Yeoman, Kristin] CDC, Natl Inst Occupat Safety & Hlth, Atlanta, GA 30333 USA. RP Hagan, JE (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM jehagan@cdc.gov OI Hagan, Jose/0000-0002-1837-6319 NR 2 TC 7 Z9 7 U1 2 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 27 PY 2015 VL 64 IS 7 BP 183 EP 185 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CC3BV UT WOS:000350220300005 PM 25719680 ER PT J AU Kateh, F Nagbe, T Kieta, A Barskey, A Gasasira, AN Driscoll, A Tucker, A Christie, A Karmo, B Scott, C Bowah, C Barradas, D Blackley, D Dweh, E Warren, F Mahoney, F Kassay, G Calvert, GM Castro, G Logan, G Appiah, G Kirking, H Koon, H Papowitz, H Walke, H Cole, IB Montgomery, J Neatherlin, J Tappero, JW Hagan, JE Forrester, J Woodring, J Mott, J Attfield, K DeCock, K Lindblade, KA Powell, K Yeoman, K Adams, L Broyles, LN Slutsker, L Larway, L Belcher, L Cooper, L Santos, M Westercamp, M Weinberg, MP Massoudi, M Dea, M Patel, M Hennessey, M Fomba, M Lubogo, M Maxwell, N Moonan, P Arzoaquoi, S Gee, S Zayzay, S Pillai, S Williams, S Zarecki, SM Yett, S James, S Grube, S Gupta, S Nelson, T Malibiche, T Frank, W Smith, W Nyenswah, T AF Kateh, Francis Nagbe, Thomas Kieta, Abraham Barskey, Albert Gasasira, Alex Ntale Driscoll, Anne Tucker, Anthony Christie, Athalia Karmo, Ben Scott, Colleen Bowah, Collin Barradas, Danielle Blackley, David Dweh, Emmanuel Warren, Felicia Mahoney, Frank Kassay, Gabriel Calvert, Geoffrey M. Castro, Georgina Logan, Gorbee Appiah, Grace Kirking, Hannah Koon, Hawa Papowitz, Heather Walke, Henry Cole, Isaac B. Montgomery, Joel Neatherlin, John Tappero, Jordan W. Hagan, Jose E. Forrester, Joseph Woodring, Joseph Mott, Joshua Attfield, Kathleen DeCock, Kevin Lindblade, Kim A. Powell, Krista Yeoman, Kristin Adams, Laura Broyles, Laura N. Slutsker, Laurence Larway, Lawrence Belcher, Lisa Cooper, Lorraine Santos, Marjorie Westercamp, Matthew Weinberg, Meghan Pearce Massoudi, Mehran Dea, Monica Patel, Monita Hennessey, Morgan Fomba, Moses Lubogo, Mutaawe Maxwell, Nikki Moonan, Patrick Arzoaquoi, Sampson Gee, Samuel Zayzay, Samuel Pillai, Satish Williams, Seymour Zarecki, Shauna Mettee Yett, Sheldon James, Stephen Grube, Steven Gupta, Sundeep Nelson, Thelma Malibiche, Theophil Frank, Wilmont Smith, Wilmot Nyenswah, Tolbert TI Rapid Response to Ebola Outbreaks in Remote Areas - Liberia, July-November 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID EPIDEMIC C1 [Kateh, Francis; Nagbe, Thomas; Kieta, Abraham; Karmo, Ben; Bowah, Collin; Dweh, Emmanuel; Kassay, Gabriel; Logan, Gorbee; Koon, Hawa; Cole, Isaac B.; Cooper, Lorraine; Fomba, Moses; Arzoaquoi, Sampson; Gee, Samuel; Zayzay, Samuel; James, Stephen; Nelson, Thelma; Frank, Wilmont; Smith, Wilmot; Nyenswah, Tolbert] Liberia Minist Hlth & Social Welf, Monrovia, Liberia. [Barskey, Albert; Driscoll, Anne; Tucker, Anthony; Christie, Athalia; Scott, Colleen; Barradas, Danielle; Blackley, David; Warren, Felicia; Mahoney, Frank; Calvert, Geoffrey M.; Castro, Georgina; Appiah, Grace; Kirking, Hannah; Walke, Henry; Montgomery, Joel; Neatherlin, John; Tappero, Jordan W.; Hagan, Jose E.; Forrester, Joseph; Woodring, Joseph; Mott, Joshua; Attfield, Kathleen; DeCock, Kevin; Lindblade, Kim A.; Powell, Krista; Yeoman, Kristin; Adams, Laura; Broyles, Laura N.; Slutsker, Laurence; Larway, Lawrence; Belcher, Lisa; Santos, Marjorie; Westercamp, Matthew; Weinberg, Meghan Pearce; Massoudi, Mehran; Dea, Monica; Patel, Monita; Hennessey, Morgan; Maxwell, Nikki; Moonan, Patrick; Pillai, Satish; Williams, Seymour; Zarecki, Shauna Mettee; Grube, Steven; Gupta, Sundeep] CDC, Atlanta, GA 30333 USA. [Gasasira, Alex Ntale] WHO, CH-1211 Geneva, Switzerland. [Papowitz, Heather; Yett, Sheldon] United Nations Childrens Fund, New York, NY USA. [Lubogo, Mutaawe; Malibiche, Theophil] African Union, Addis Ababa, Ethiopia. RP Lindblade, KA (reprint author), CDC, Atlanta, GA 30333 USA. EM klindblade@cdc.gov OI Moonan, Patrick/0000-0002-3550-2065; Hagan, Jose/0000-0002-1837-6319 NR 5 TC 13 Z9 13 U1 0 U2 16 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 27 PY 2015 VL 64 IS 7 BP 188 EP 192 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CC3BV UT WOS:000350220300007 PM 25719682 ER PT J AU Rosenthal, M Pedersen, R Leibsle, S Hill, V Carter, K Roellig, DM AF Rosenthal, Mariana Pedersen, Randi Leibsle, Scott Hill, Vincent Carter, Kris Roellig, Dawn M. TI Cryptosporidiosis Associated with Consumption of Unpasteurized Goat Milk - Idaho, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID UNITED-STATES; OUTBREAKS C1 [Rosenthal, Mariana] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Pedersen, Randi] Southwest Dist Hlth Idaho, Caldwell, ID USA. [Hill, Vincent] CDC, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. RP Rosenthal, M (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM rosenthalm@dhw.idaho.gov NR 5 TC 3 Z9 3 U1 0 U2 2 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 27 PY 2015 VL 64 IS 7 BP 194 EP 195 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CC3BV UT WOS:000350220300009 PM 25719684 ER PT J AU Mitchell, SN Kakani, EG South, A Howell, PI Waterhouse, RM Catteruccia, F AF Mitchell, Sara N. Kakani, Evdoxia G. South, Adam Howell, Paul I. Waterhouse, Robert M. Catteruccia, Flaminia TI Evolution of sexual traits influencing vectorial capacity in anopheline mosquitoes SO SCIENCE LA English DT Article ID DROSOPHILA-MELANOGASTER; GAMBIAE; FEMALES; REPRODUCTION; COOPERATION; MALES AB The availability of genome sequences from 16 anopheline species provides unprecedented opportunities to study the evolution of reproductive traits relevant for malaria transmission. In Anopheles gambiae, a likely candidate for sexual selection is male 20-hydroxyecdysone (20E). Sexual transfer of this steroid hormone as part of a mating plug dramatically changes female physiological processes intimately tied to vectorial capacity. By combining phenotypic studies with ancestral state reconstructions and phylogenetic analyses, we show that mating plug transfer and male 20E synthesis are both derived characters that have coevolved in anophelines, driving the adaptation of a female 20E-interacting protein that promotes oogenesis via mechanisms also favoring Plasmodium survival. Our data reveal coevolutionary dynamics of reproductive traits between the sexes likely to have shaped the ability of anophelines to transmit malaria. C1 [Mitchell, Sara N.; Kakani, Evdoxia G.; South, Adam; Catteruccia, Flaminia] Harvard Univ, TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA. [Kakani, Evdoxia G.; Catteruccia, Flaminia] Univ Perugia, Dipartimento Med Sperimentale, I-06100 Perugia, Italy. [Howell, Paul I.] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. [Waterhouse, Robert M.] Univ Geneva, Sch Med, Dept Genet Med & Dev, CH-1211 Geneva, Switzerland. [Waterhouse, Robert M.] Swiss Inst Bioinformat, CH-1211 Geneva, Switzerland. [Waterhouse, Robert M.] MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA. [Waterhouse, Robert M.] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA. RP Catteruccia, F (reprint author), Harvard Univ, TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA. EM fcatter@hsph.harvard.edu RI Waterhouse, Robert/A-1858-2010 OI Waterhouse, Robert/0000-0003-4199-9052 FU European Research Council [260897]; William F. Milton Fund (Harvard Medical School); NIH [NIH 1R01AI104956-01A1] FX We thank E. Lund and D. Clarke for help with mosquito rearing and insectary procedures and M. Bernardi for assistance with artwork. We are grateful to D. Neafsey and N. Besansky for numerous helpful discussions and to S. Lewis, D. Neafsey, M. Mota, and members of the Catteruccia laboratory for careful reading of the manuscript. This work was sponsored in part by the following grants awarded to F.C.: a European Research Council FP7 ERC Starting Grant (grant Anorep, ID: 260897), a William F. Milton Fund grant (Harvard Medical School 2013), and an NIH grant (grant ID: NIH 1R01AI104956-01A1). S. N. M., E.G.K., A. S., and F.C. designed the experiments. P.I.H. provided experimental material, and S. N. M., E.G.K, and P.I.H. performed the experiments. S. N. M., E.G.K, A. S., and R.M.W. analyzed the data. S.N.M., E.G.K., A.S., and F.C. wrote the manuscript. S.N.M., E.G.K., and A.S. contributed equally to this study. All gene sequences are freely available via given gene identifiers from VectorBase (www.vectorbase.org). The single-copy ortholog sequences used to produce the species phylogeny are available via OrthoDB (http://cegg.unige.ch/orthodbmoz2). Protein sequence alignments employed for the species and MISO-AGAP002621 phylogenies are available via DRYAD: doi:10.5061/dryad.6f576. NR 23 TC 11 Z9 11 U1 8 U2 54 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 EI 1095-9203 J9 SCIENCE JI Science PD FEB 27 PY 2015 VL 347 IS 6225 BP 985 EP 988 DI 10.1126/science.1259435 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CB9NQ UT WOS:000349958900036 PM 25722409 ER PT J AU Lessa, FC Mu, Y Bamberg, WM Beldavs, ZG Dumyati, GK Dunn, JR Farley, MM Holzbauer, SM Meek, JI Phipps, EC Wilson, LE Winston, LG Cohen, JA Limbago, BM Fridkin, SK Gerding, DN McDonald, LC AF Lessa, Fernanda C. Mu, Yi Bamberg, Wendy M. Beldavs, Zintars G. Dumyati, Ghinwa K. Dunn, John R. Farley, Monica M. Holzbauer, Stacy M. Meek, James I. Phipps, Erin C. Wilson, Lucy E. Winston, Lisa G. Cohen, Jessica A. Limbago, Brandi M. Fridkin, Scott K. Gerding, Dale N. McDonald, L. Clifford TI Burden of Clostridium difficile Infection in the United States SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID RESISTANT STAPHYLOCOCCUS-AUREUS; CHANGING EPIDEMIOLOGY; HOSPITAL-ONSET; RATES; DISEASE; PREVALENCE; VALIDATION; PREDICTORS; MORTALITY; PROGRAM AB BACKGROUND The magnitude and scope of Clostridium difficile infection in the United States continue to evolve. METHODS In 2011, we performed active population-and laboratory-based surveillance across 10 geographic areas in the United States to identify cases of C. difficile infection (stool specimens positive for C. difficile on either toxin or molecular assay in residents >= 1 year of age). Cases were classified as community-associated or health care-associated. In a sample of cases of C. difficile infection, specimens were cultured and isolates underwent molecular typing. We used regression models to calculate estimates of national incidence and total number of infections, first recurrences, and deaths within 30 days after the diagnosis of C. difficile infection. RESULTS A total of 15,461 cases of C. difficile infection were identified in the 10 geographic areas; 65.8% were health care-associated, but only 24.2% had onset during hospitalization. After adjustment for predictors of disease incidence, the estimated number of incident C. difficile infections in the United States was 453,000 (95% confidence interval [CI], 397,100 to 508,500). The incidence was estimated to be higher among females (rate ratio, 1.26; 95% CI, 1.25 to 1.27), whites (rate ratio, 1.72; 95% CI, 1.56 to 2.0), and persons 65 years of age or older (rate ratio, 8.65; 95% CI, 8.16 to 9.31). The estimated number of first recurrences of C. difficile infection was 83,000 (95% CI, 57,000 to 108,900), and the estimated number of deaths was 29,300 (95% CI, 16,500 to 42,100). The North American pulsed-field gel electrophoresis type 1 (NAP1) strain was more prevalent among health care-associated infections than among community-associated infections (30.7% vs. 18.8%, P< 0.001) CONCLUSIONS C. difficile was responsible for almost half a million infections and was associated with approximately 29,000 deaths in 2011. C1 [Lessa, Fernanda C.; Mu, Yi; Cohen, Jessica A.; Limbago, Brandi M.; Fridkin, Scott K.; McDonald, L. Clifford] Ctr Dis Control & Prevent CDC, Natl Ctr Emerging & Zoonot Infect Dis, Div Healthcare Qual Promot, Atlanta, GA USA. [Farley, Monica M.] Emory Univ, Sch Med, Dept Med, Atlanta, GA USA. [Farley, Monica M.] Atlanta Vet Affairs Med Ctr, Atlanta, GA USA. [Holzbauer, Stacy M.] CDC Off Publ Hlth Preparedness & Response, Div State & Local Readiness, Atlanta, GA USA. [Cohen, Jessica A.] Atlanta Res & Educ Fdn, Atlanta, GA USA. [Bamberg, Wendy M.] Colorado Dept Publ Hlth & Environm, Denver, CO USA. [Beldavs, Zintars G.] Oregon Hlth Author, Publ Hlth Div, Portland, OR USA. [Dumyati, Ghinwa K.] Univ Rochester, Med Ctr, Rochester, NY 14642 USA. [Dunn, John R.] Tennessee Dept Hlth, Nashville, TN USA. [Holzbauer, Stacy M.] Minnesota Dept Hlth, St Paul, MN USA. [Meek, James I.] Yale Univ, Sch Publ Hlth, Connecticut Emerging Infect Program, New Haven, CT USA. [Phipps, Erin C.] Univ New Mexico, New Mexico Emerging Infect Program, Albuquerque, NM 87131 USA. [Wilson, Lucy E.] Maryland Dept Hlth & Mental Hyg, Baltimore, MD USA. [Winston, Lisa G.] Univ Calif San Francisco, Sch Med, Dept Med, San Francisco, CA USA. [Gerding, Dale N.] Loyola Univ, Chicago Stritch Sch Med, Dept Med, Maywood, IL 60153 USA. [Gerding, Dale N.] Edward Hines Jr Vet Affairs Hosp, Hines, IL USA. RP Lessa, FC (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,MS C-25, Atlanta, GA 30333 USA. EM flessa@cdc.gov FU Centers for Disease Control and Prevention FX Funded by the Centers for Disease Control and Prevention. NR 49 TC 288 Z9 292 U1 13 U2 40 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD FEB 26 PY 2015 VL 372 IS 9 BP 825 EP 834 DI 10.1056/NEJMoa1408913 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA CB8SQ UT WOS:000349901700007 PM 25714160 ER PT J AU Jain, S Williams, DJ Arnold, SR Ampofo, K Bramley, AM Reed, C Stockmann, C Anderson, EJ Grijalva, CG Self, WH Zhu, YW Patel, A Hymas, W Chappell, JD Kaufman, RA Kan, JH Dansie, D Lenny, N Hillyard, DR Haynes, LM Levine, M Lindstrom, S Winchell, JM Katz, JM Erdman, D Schneider, E Hicks, LA Wunderink, RG Edwards, KM Pavia, AT McCullers, JA Finelli, L AF Jain, Seema Williams, Derek J. Arnold, Sandra R. Ampofo, Krow Bramley, Anna M. Reed, Carrie Stockmann, Chris Anderson, Evan J. Grijalva, Carlos G. Self, Wesley H. Zhu, Yuwei Patel, Anami Hymas, Weston Chappell, James D. Kaufman, Robert A. Kan, J. Herman Dansie, David Lenny, Noel Hillyard, David R. Haynes, Lia M. Levine, Min Lindstrom, Stephen Winchell, Jonas M. Katz, Jacqueline M. Erdman, Dean Schneider, Eileen Hicks, Lauri A. Wunderink, Richard G. Edwards, Kathryn M. Pavia, Andrew T. McCullers, Jonathan A. Finelli, Lyn CA CDC EPIC Study Team TI Community-Acquired Pneumonia Requiring Hospitalization among US Children SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID POLYMERASE-CHAIN-REACTION; PNEUMOCOCCAL CONJUGATE VACCINE; ACUTE RESPIRATORY ILLNESS; MYCOPLASMA-PNEUMONIAE; INFECTIOUS-DISEASES; VIRAL-INFECTIONS; REACTION ASSAYS; PCR ASSAY; DIAGNOSIS; TRACT AB BACKGROUND Incidence estimates of hospitalizations for community-acquired pneumonia among children in the United States that are based on prospective data collection are limited. Updated estimates of pneumonia that has been confirmed radiographically and with the use of current laboratory diagnostic tests are needed. METHODS We conducted active population-based surveillance for community-acquired pneumonia requiring hospitalization among children younger than 18 years of age in three hospitals in Memphis, Nashville, and Salt Lake City. We excluded children with recent hospitalization or severe immunosuppression. Blood and respiratory specimens were systematically collected for pathogen detection with the use of multiple methods. Chest radiographs were reviewed independently by study radiologists. RESULTS From January 2010 through June 2012, we enrolled 2638 of 3803 eligible children (69%), 2358 of whom (89%) had radiographic evidence of pneumonia. The median age of the children was 2 years (interquartile range, 1 to 6); 497 of 2358 children (21%) required intensive care, and 3 (<1%) died. Among 2222 children with radiographic evidence of pneumonia and with specimens available for bacterial and viral testing, a viral or bacterial pathogen was detected in 1802 (81%), one or more viruses in 1472 (66%), bacteria in 175 (8%), and both bacterial and viral pathogens in 155 (7%). The annual incidence of pneumonia was 15.7 cases per 10,000 children (95% confidence interval [CI], 14.9 to 16.5), with the highest rate among children younger than 2 years of age (62.2 cases per 10,000 children; 95% CI, 57.6 to 67.1). Respiratory syncytial virus was more common among children younger than 5 years of age than among older children (37% vs. 8%), as were adenovirus (15% vs. 3%) and human metapneumovirus (15% vs. 8%). Mycoplasma pneumoniae was more common among children 5 years of age or older than among younger children (19% vs. 3%). CONCLUSIONS The burden of hospitalization for children with community-acquired pneumonia was highest among the very young, with respiratory viruses the most commonly detected causes of pneumonia. C1 [Jain, Seema; Bramley, Anna M.; Reed, Carrie; Haynes, Lia M.; Levine, Min; Lindstrom, Stephen; Winchell, Jonas M.; Katz, Jacqueline M.; Erdman, Dean; Schneider, Eileen; Hicks, Lauri A.; Finelli, Lyn] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Williams, Derek J.; Grijalva, Carlos G.; Self, Wesley H.; Zhu, Yuwei; Chappell, James D.; Kan, J. Herman; Edwards, Kathryn M.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA. [Williams, Derek J.; Edwards, Kathryn M.] Monroe Carell Jr Childrens Hosp Vanderbilt, Nashville, TN USA. [Williams, Derek J.; Edwards, Kathryn M.] Vanderbilt Vaccine Res Program, Nashville, TN USA. [Arnold, Sandra R.; Patel, Anami; Lenny, Noel; McCullers, Jonathan A.] Le Bonheur Childrens Hosp, Memphis, TN USA. [Arnold, Sandra R.; Patel, Anami; Kaufman, Robert A.; Lenny, Noel; McCullers, Jonathan A.] Univ Tennessee, Ctr Hlth Sci, Memphis, TN 38163 USA. [Kaufman, Robert A.; McCullers, Jonathan A.] St Jude Childrens Res Hosp, Memphis, TN 38105 USA. [Ampofo, Krow; Stockmann, Chris; Hymas, Weston; Dansie, David; Hillyard, David R.; Pavia, Andrew T.] Univ Utah, Hlth Sci Ctr, Salt Lake City, UT USA. [Anderson, Evan J.; Wunderink, Richard G.] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA. RP Jain, S (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,MS A-32, Atlanta, GA 30333 USA. EM bwc8@cdc.gov OI Wunderink, Richard/0000-0002-8527-4195 FU Influenza Division of the National Center for Immunization and Respiratory Diseases FX Funded by the Influenza Division of the National Center for Immunization and Respiratory Diseases. NR 42 TC 127 Z9 140 U1 7 U2 29 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD FEB 26 PY 2015 VL 372 IS 9 BP 835 EP 845 DI 10.1056/NEJMoa1405870 PG 11 WC Medicine, General & Internal SC General & Internal Medicine GA CB8SQ UT WOS:000349901700008 PM 25714161 ER PT J AU Oboho, IK Tomczyk, SM Al-Asmari, AM Banjar, AA Al-Mugti, H Aloraini, MS Alkhaldi, KZ Almohammadi, EL Alraddadi, BM Gerber, SI Swerdlow, DL Watson, JT Madani, TA AF Oboho, Ikwo K. Tomczyk, Sara M. Al-Asmari, Ahmad M. Banjar, Ayman A. Al-Mugti, Hani Aloraini, Muhannad S. Alkhaldi, Khulud Z. Almohammadi, Emad L. Alraddadi, Basem M. Gerber, Susan I. Swerdlow, David L. Watson, John T. Madani, Tariq A. TI 2014 MERS-CoV Outbreak in Jeddah - A Link to Health Care Facilities SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID RESPIRATORY SYNDROME CORONAVIRUS; SAUDI-ARABIA AB BACKGROUND A marked increase in the number of cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection occurred in Jeddah, Saudi Arabia, in early 2014. We evaluated patients with MERS-CoV infection in Jeddah to explore reasons for this increase and to assess the epidemiologic and clinical features of this disease. METHODS We identified all cases of laboratory-confirmed MERS-CoV infection in Jeddah that were reported to the Saudi Arabian Ministry of Health from January 1 through May 16, 2014. We conducted telephone interviews with symptomatic patients who were not health care personnel, and we reviewed hospital records. We identified patients who were reported as being asymptomatic and interviewed them regarding a history of symptoms in the month before testing. Descriptive analyses were performed. RESULTS Of 255 patients with laboratory-confirmed MERS-CoV infection, 93 died (case fatality rate, 36.5%). The median age of all patients was 45 years (interquartile range, 30 to 59), and 174 patients (68.2%) were male. A total of 64 patients (25.1%) were reported to be asymptomatic. Of the 191 symptomatic patients, 40 (20.9%) were health care personnel. Among the 151 symptomatic patients who were not health care personnel, 112 (74.2%) had data that could be assessed, and 109 (97.3%) of these patients had had contact with a health care facility, a person with a confirmed case of MERS-CoV infection, or someone with severe respiratory illness in the 14 days before the onset of illness. The remaining 3 patients (2.7%) reported no such contacts. Of the 64 patients who had been reported as asymptomatic, 33 (52%) were interviewed, and 26 of these 33 (79%) reported at least one symptom that was consistent with a viral respiratory illness. CONCLUSIONS The majority of patients in the Jeddah MERS-CoV outbreak had contact with a health care facility, other patients, or both. This highlights the role of health care-associated transmission. C1 [Oboho, Ikwo K.; Tomczyk, Sara M.; Gerber, Susan I.; Swerdlow, David L.; Watson, John T.] Ctr Dis Control & Prevent CDC, Atlanta, GA USA. [Oboho, Ikwo K.; Tomczyk, Sara M.] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Al-Asmari, Ahmad M.; Banjar, Ayman A.; Alkhaldi, Khulud Z.; Almohammadi, Emad L.; Alraddadi, Basem M.; Madani, Tariq A.] Minist Hlth, Jeddah, Saudi Arabia. [Al-Mugti, Hani] Minist Natl Guard, Natl Guard Hlth Affairs, Community & Prevent Med Ctr, Jeddah, Saudi Arabia. [Alraddadi, Basem M.] King Faisal Specialist Hosp & Res Ctr, Jeddah, Saudi Arabia. [Madani, Tariq A.] King Abdulaziz Univ, Fac Med, Dept Med, Jeddah 21413, Saudi Arabia. [Aloraini, Muhannad S.] Al Qassim Univ, Fac Med, Dept Family & Community Med, Al Qassim, Saudi Arabia. RP Madani, TA (reprint author), King Abdulaziz Univ, Dept Med, POB 80215, Jeddah 21589, Saudi Arabia. EM tmadani@kau.edu.sa FU Ministry of Health, Saudi Arabia; U.S. Centers for Disease Control and Prevention FX Supported by the Ministry of Health, Saudi Arabia, and by the U.S. Centers for Disease Control and Prevention. NR 16 TC 99 Z9 103 U1 1 U2 12 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD FEB 26 PY 2015 VL 372 IS 9 BP 846 EP 854 DI 10.1056/NEJMoa1408636 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA CB8SQ UT WOS:000349901700009 PM 25714162 ER PT J AU Breiman, RF Cosmas, L Njenga, MK Williamson, J Mott, JA Katz, MA Erdman, DD Schneider, E Oberste, MS Neatherlin, JC Njuguna, H Ondari, DM Odero, K Okoth, GO Olack, B Wamola, N Montgomery, JM Fields, BS Feikin, DR AF Breiman, Robert F. Cosmas, Leonard Njenga, M. Kariuki Williamson, John Mott, Joshua A. Katz, Mark A. Erdman, Dean D. Schneider, Eileen Oberste, M. Steven Neatherlin, John C. Njuguna, Henry Ondari, Daniel M. Odero, Kennedy Okoth, George O. Olack, Beatrice Wamola, Newton Montgomery, Joel M. Fields, Barry S. Feikin, Daniel R. TI Severe acute respiratory infection in children in a densely populated urban slum in Kenya, 2007-2011 SO BMC INFECTIOUS DISEASES LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; REAL-TIME PCR; DEVELOPING-COUNTRIES; CHILDHOOD PNEUMONIA; SYNCYTIAL VIRUS; YOUNG-CHILDREN; MYCOPLASMA-PNEUMONIAE; HOSPITALIZED CHILDREN; SYSTEMATIC ANALYSIS; HUMAN RHINOVIRUSES AB Background: Reducing acute respiratory infection burden in children in Africa remains a major priority and challenge. We analyzed data from population-based infectious disease surveillance for severe acute respiratory illness (SARI) among children < 5 years of age in Kibera, a densely populated urban slum in Nairobi, Kenya. Methods: Surveillance was conducted among a monthly mean of 5,874 (range = 5,778-6,411) children < 5 years old in two contiguous villages in Kibera. Participants had free access to the study clinic and their health events and utilization were noted during biweekly home visits. Patients meeting criteria for SARI (WHO-defined severe or very severe pneumonia, or oxygen saturation < 90%) from March 1, 2007-February 28, 2011 had blood cultures processed for bacteria, and naso-and oro-pharyngeal swabs collected for quantitative real-time reverse transcription polymerase chain reaction testing for influenza viruses, parainfluenza viruses (PIV), respiratory syncytial virus (RSV), adenovirus, and human metapneumovirus (hMPV). Swabs collected during January 1, 2009 -February 28, 2010 were also tested for rhinoviruses, enterovirus, parechovirus, Mycoplasma pneumoniae, and Legionella species. Swabs were collected for simultaneous testing from a selected group of control-children visiting the clinic without recent respiratory or diarrheal illnesses. Results: SARI overall incidence was 12.4 cases/100 person-years of observation (PYO) and 30.4 cases/100 PYO in infants. When comparing detection frequency in swabs from 815 SARI cases and 115 healthy controls, only RSV and influenza A virus were significantly more frequently detected in cases, although similar trends neared statistical significance for PIV, adenovirus and hMPV. The incidence for RSV was 2.8 cases/100 PYO and for influenza A was 1.0 cases/100 PYO. When considering all PIV, the rate was 1.1 case/100 PYO and the rate per 100 PYO for SARI-associated disease was 1.5 for adenovirus and 0.9 for hMPV. RSV and influenza A and B viruses were estimated to account for 16.2% and 6.7% of SARI cases, respectively; when taken together, PIV, adenovirus, and hMPV may account for >20% additional cases. Conclusions: Influenza viruses and RSV (and possibly PIV, hMPV and adenoviruses) are important pathogens to consider when developing technologies and formulating strategies to treat and prevent SARI in children. C1 [Breiman, Robert F.; Cosmas, Leonard; Njenga, M. Kariuki; Williamson, John; Mott, Joshua A.; Katz, Mark A.; Neatherlin, John C.; Njuguna, Henry; Montgomery, Joel M.; Fields, Barry S.; Feikin, Daniel R.] US Ctr Dis Control & Prevent, CDC Kenya Off, Global Dis Detect Div, Nairobi, Kenya. [Breiman, Robert F.; Cosmas, Leonard; Njenga, M. Kariuki; Williamson, John; Mott, Joshua A.; Katz, Mark A.; Neatherlin, John C.; Njuguna, Henry; Montgomery, Joel M.; Fields, Barry S.; Feikin, Daniel R.] US Ctr Dis Control & Prevent, CDC Kenya Off, Influenza Div, Nairobi, Kenya. [Breiman, Robert F.; Njenga, M. Kariuki; Williamson, John; Katz, Mark A.; Neatherlin, John C.; Njuguna, Henry; Montgomery, Joel M.; Fields, Barry S.; Feikin, Daniel R.] Ctr Dis Control & Prevent, Global Dis Detect Branch, Div Global Hlth Protect, Ctr Global Hlth, Atlanta, GA USA. [Erdman, Dean D.; Schneider, Eileen; Oberste, M. Steven; Feikin, Daniel R.] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Njenga, M. Kariuki; Ondari, Daniel M.; Odero, Kennedy; Okoth, George O.; Olack, Beatrice; Wamola, Newton] Kenya Med Res Inst KEMRI, Nairobi, Kenya. RP Breiman, RF (reprint author), Emory Univ, Emory Global Hlth Inst, 1599 Clifton Rd, Atlanta, GA 30322 USA. EM rfbreiman@emory.edu FU US Centers for Disease Control and Prevention (CDC) FX The authors would like to thank the people living in the Gatwikera and Soweto villages of Kibera and the community leaders, who, over the years, have graciously allowed our field teams to enter their homes on a regular basis to collect information on their health. This study was funded by the US Centers for Disease Control and Prevention (CDC), which contributed to study design, collection, analysis and interpretation of data, as well as the writing of the manuscript, since several of the authors are employees of CDC. The authors would also like to thank the Kenya Medical Research Institute (KEMRI), its leadership and staff; without the collaboration between KEMRI and CDC, this work would not have been possible. NR 73 TC 6 Z9 6 U1 1 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD FEB 25 PY 2015 VL 15 AR 95 DI 10.1186/s12879-015-0827-x PG 11 WC Infectious Diseases SC Infectious Diseases GA CC8DB UT WOS:000350597200001 PM 25879805 ER PT J AU Newman, EA Eisen, L Eisen, RJ Fedorova, N Hasty, JM Vaughn, C Lane, RS AF Newman, Erica A. Eisen, Lars Eisen, Rebecca J. Fedorova, Natalia Hasty, Jeomhee M. Vaughn, Charles Lane, Robert S. TI Borrelia burgdorferi Sensu Lato Spirochetes in Wild Birds in Northwestern California: Associations with Ecological Factors, Bird Behavior and Tick Infestation SO PLOS ONE LA English DT Article ID IXODES-PACIFICUS ACARI; LYME-DISEASE SPIROCHETE; NORTH-AMERICAN-BIRDS; LIZARD SCELOPORUS-OCCIDENTALIS; BLACK-LEGGED TICK; POINT COUNTS; RESERVOIR COMPETENCE; CLIMATIC CONDITIONS; RELATIVE ABUNDANCE; SPECIES-DIVERSITY AB Although Borrelia burgdorferi sensu lato (s.l.) are found in a great diversity of vertebrates, most studies in North America have focused on the role of mammals as spirochete reservoir hosts. We investigated the roles of birds as hosts for subadult Ixodes pacificus ticks and potential reservoirs of the Lyme disease spirochete B. burgdorferi sensu stricto (s.s.) in northwestern California. Overall, 623 birds representing 53 species yielded 284 I. pacificus larvae and nymphs. We used generalized linearmodels and zero-inflated negative binomial models to determine associations of bird behaviors, taxonomic relationships and infestation by I. pacificus with borrelial infection in the birds. Infection status in birds was best explained by taxonomic order, number of infesting nymphs, sampling year, and log-transformed average body weight. Presence and counts of larvae and nymphs could be predicted by ground-or bark-foraging behavior and contact with dense oak woodland. Molecular analysis yielded the first reported detection of Borrelia bissettii in birds. Moreover, our data suggest that the Golden-crowned Sparrow (Zonotrichia atricapilla), a non-resident species, could be an important reservoir for B. burgdorferi s.s. Of 12 individual birds (9 species) that carried B. burgdorferi s.l.-infected larvae, no birds carried the same genospecies of B. burgdorferi s.l. in their blood as were present in the infected larvae removed from them. Possible reasons for this discrepancy are discussed. Our study is the first to explicitly incorporate both taxonomic relationships and behaviors as predictor variables to identify putative avian reservoirs of B. burgdorferi s.l. Our findings underscore the importance of bird behavior to explain local tick infestation and Borrelia infection in these animals, and suggest the potential for bird-mediated geographic spread of vector ticks and spirochetes in the far-western United States. C1 [Newman, Erica A.] Univ Calif Berkeley, Energy & Resources Grp, Berkeley, CA 94720 USA. [Newman, Erica A.; Fedorova, Natalia; Lane, Robert S.] Univ Calif Berkeley, Dept Environm Sci Policy & Management, Berkeley, CA 94720 USA. [Eisen, Lars] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA. [Eisen, Lars; Eisen, Rebecca J.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80522 USA. [Hasty, Jeomhee M.] Hawaii Dept Hlth, Sanitat Branch, Honolulu, HI 96813 USA. [Vaughn, Charles] Univ Calif Hopland, Res & Extens Ctr, Hopland, CA 95449 USA. RP Newman, EA (reprint author), Univ Calif Berkeley, Energy & Resources Grp, 310 Barrows Hall, Berkeley, CA 94720 USA. EM newmane@berkeley.edu OI Newman, Erica/0000-0001-6433-8594 FU National Institutes of Health [AI22501]; National Science Foundation FX This research was funded in part by a grant from the National Institutes of Health (AI22501) to RSL, and by a Graduate Research Fellowship from the National Science Foundation to EAN. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 90 TC 10 Z9 10 U1 5 U2 26 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 25 PY 2015 VL 10 IS 2 AR e0118146 DI 10.1371/journal.pone.0118146 PG 26 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CC2IM UT WOS:000350168700055 PM 25714376 ER PT J AU Cavallaro, KF Sandhu, HS Hyde, TB Johnson, BW Fischer, M Mayer, LW Clark, TA Pallansch, MA Yin, ZD Zuo, SY Hadler, SC Diorditsa, S Hasan, ASMM Bose, AS Dietz, V AF Cavallaro, Kathleen F. Sandhu, Hardeep S. Hyde, Terri B. Johnson, Barbara W. Fischer, Marc Mayer, Leonard W. Clark, Thomas A. Pallansch, Mark A. Yin, Zundong Zuo, Shuyan Hadler, Stephen C. Diorditsa, Serguey Hasan, A. S. M. Mainul Bose, Anindya S. Dietz, Vance CA AMES Study Grp TI Expansion of syndromic vaccine preventable disease surveillance to include bacterial meningitis and Japanese encephalitis: Evaluation of adapting polio and measles laboratory networks in Bangladesh, China and India, 2007-2008 SO VACCINE LA English DT Article DE Vaccine preventable diseases; VPD; Surveillance; Meningitis; Japanese encephalitis ID POLIOMYELITIS; EPIDEMIOLOGY; RATIONALE; PNEUMONIA; PROGRESS; BURDEN; VIRUS; IGM AB Background: Surveillance for acute flaccid paralysis with laboratory confirmation has been a key strategy in the global polio eradication initiative, and the laboratory platform established for polio testing has been expanded in many countries to include surveillance for cases of febrile rash illness to identify measles and rubella cases. Vaccine-preventable disease surveillance is essential to detect outbreaks, define disease burden, guide vaccination strategies and assess immunization impact. Vaccines now exist to prevent Japanese encephalitis am and some etiologies of bacterial meningitis. Methods: We evaluated the feasibility of expanding polio-measles surveillance and laboratory networks to detect bacterial meningitis and JE, using surveillance for acute meningitis-encephalitis syndrome in Bangladesh and China and acute encephalitis syndrome in India. We developed nine syndromic surveillance performance indicators based on international surveillance guidelines and calculated scores using supervisory visit reports, annual reports, and case-based surveillance data. Results: Scores, variable by country and targeted disease, were highest for the presence of national guidelines, sustainability, training, availability of JE laboratory resources, and effectiveness of using polio-measles networks for JE surveillance. Scores for effectiveness of building on polio-measles networks for bacterial meningitis surveillance and specimen referral were the lowest, because of differences in specimens and techniques. Conclusions: Polio-measles surveillance and laboratory networks provided useful infrastructure for establishing syndromic surveillance and building capacity for JE diagnosis, but were less applicable for bacterial meningitis. Laboratory-supported surveillance for vaccine-preventable bacterial diseases will require substantial technical and financial support to enhance local diagnostic capacity. Published by Elsevier Ltd. C1 [Cavallaro, Kathleen F.; Sandhu, Hardeep S.; Hyde, Terri B.; Dietz, Vance] US Ctr Dis Control & Prevent, Global Immunizat Div, Atlanta, GA 30333 USA. [Johnson, Barbara W.; Fischer, Marc] US Ctr Dis Control & Prevent, Div Vector Borne Dis, Atlanta, GA 30333 USA. [Mayer, Leonard W.; Clark, Thomas A.] US Ctr Dis Control & Prevent, Div Bacterial Dis, Atlanta, GA 30333 USA. [Pallansch, Mark A.] US Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA. [Yin, Zundong] Chinese Ctr Dis Control & Prevent, Natl Immunizat Programme, Beijing, Peoples R China. [Zuo, Shuyan; Hadler, Stephen C.] WHO, Beijing, Peoples R China. [Diorditsa, Serguey] WHO, Dhaka, Bangladesh. [Bose, Anindya S.] WHO, Natl Polio Surveillance Project, New Delhi, India. [Hasan, A. S. M. Mainul] WHO, Male, Maldives. RP Cavallaro, KF (reprint author), US Ctr Dis Control & Prevent, Ctr Global Hlth, Global Immunizat Div, Atlanta, GA 30333 USA. EM KCavallaro@cdc.gov FU United States Centers for Disease Control and Prevention, Atlanta, Georgia FX Funding for this evaluation was provided by the United States Centers for Disease Control and Prevention, Atlanta, Georgia. NR 41 TC 2 Z9 2 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD FEB 25 PY 2015 VL 33 IS 9 BP 1168 EP 1175 DI 10.1016/j.vaccine.2015.01.004 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA CC2QO UT WOS:000350189900011 PM 25597940 ER PT J AU Newton, PN Schellenberg, D Ashley, EA Ravinetto, R Green, MD ter Kuile, FO Tabernero, P White, NJ Guerin, PJ AF Newton, Paul N. Schellenberg, David Ashley, Elizabeth A. Ravinetto, Raffaella Green, Michael D. ter Kuile, Feiko O. Tabernero, Patricia White, Nicholas J. Guerin, Philippe J. TI Quality assurance of drugs used in clinical trials: proposal for adapting guidelines SO BMJ-BRITISH MEDICAL JOURNAL LA English DT Editorial Material ID SETTINGS C1 [Newton, Paul N.] Mahosot Hosp, Microbiol Lab, Lao Oxford Mahosot Hosp, Wellcome Trust Res Unit, Viangchan, Laos. [Schellenberg, David] London Sch Hyg & Trop Med, London WC1, England. [Ashley, Elizabeth A.] Mahidol Univ, Fac Trop Med, Mahidol Oxford Res Unit, Bangkok, Thailand. [Ravinetto, Raffaella] Inst Trop Med, Dept Clin Sci, B-2000 Antwerp, Belgium. [Green, Michael D.] Ctr Dis Control & Prevent, Atlanta, GA USA. [ter Kuile, Feiko O.] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England. [Tabernero, Patricia; Guerin, Philippe J.] Univ Oxford, Ctr Trop Med & Global Hlth, Worldwide Antimalarial Resistance Network, Oxford OX1 2JD, England. [White, Nicholas J.] Univ Oxford, Churchill Hosp, Nuffield Dept Med, Ctr Trop Med & Global Hlth, Oxford OX1 2JD, England. RP Newton, PN (reprint author), Mahosot Hosp, Microbiol Lab, Lao Oxford Mahosot Hosp, Wellcome Trust Res Unit, Viangchan, Laos. EM paul@tropmedres.ac OI ter Kuile, Feiko/0000-0003-3663-5617; Guerin, Philippe/0000-0002-6008-2963 FU Wellcome Trust [, 093956] NR 26 TC 2 Z9 2 U1 0 U2 3 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1756-1833 J9 BMJ-BRIT MED J JI BMJ-British Medical Journal PD FEB 25 PY 2015 VL 350 AR h602 DI 10.1136/bmj.h602 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA CC4AM UT WOS:000350292900008 PM 25716700 ER PT J AU Duong, YT Kassanjee, R Welte, A Morgan, M De, A Dobbs, T Rottinghaus, E Nkengasong, J Curlin, ME Kittinunvorakoon, C Raengsakulrach, B Martin, M Choopanya, K Vanichseni, S Jiang, Y Qiu, MF Yu, HY Hao, Y Shah, N Le, LV Kim, AA Nguyen, TA Ampofo, W Parekh, BS AF Duong, Yen T. Kassanjee, Reshma Welte, Alex Morgan, Meade De, Anindya Dobbs, Trudy Rottinghaus, Erin Nkengasong, John Curlin, Marcel E. Kittinunvorakoon, Chonticha Raengsakulrach, Boonyos Martin, Michael Choopanya, Kachit Vanichseni, Suphak Jiang, Yan Qiu, Maofeng Yu, Haiying Hao, Yan Shah, Neha Linh-Vi Le Kim, Andrea A. Tuan Anh Nguyen Ampofo, William Parekh, Bharat S. TI Recalibration of the Limiting Antigen Avidity EIA to Determine Mean Duration of Recent Infection in Divergent HIV-1 Subtypes SO PLOS ONE LA English DT Article ID CAPTURE ENZYME-IMMUNOASSAY; IMMUNODEFICIENCY-VIRUS TYPE-1; SUB-SAHARAN AFRICA; UNITED-STATES; ASSAY; BED; SEROCONVERSION; PREVENTION; ANTIBODIES; THAILAND AB Background Mean duration of recent infection (MDRI) and misclassification of long-term HIV-1 infections, as proportion false recent (PFR), are critical parameters for laboratory-based assays for estimating HIV-1 incidence. Recent review of the data by us and others indicated that MDRI of LAg-Avidity EIA estimated previously required recalibration. We present here results of recalibration efforts using >250 seroconversion panels and multiple statistical methods to ensure accuracy and consensus. Methods A total of 2737 longitudinal specimens collected from 259 seroconverting individuals infected with diverse HIV-1 subtypes were tested with the LAg-Avidity EIA as previously described. Data were analyzed for determination of MDRI at ODn cutoffs of 1.0 to 2.0 using 7 statistical approaches and sub-analyzed by HIV-1 subtypes. In addition, 3740 specimens from individuals with infection >1 year, including 488 from patients with AIDS, were tested for PFR at varying cutoffs. Results Using different statistical methods, MDRI values ranged from 88-94 days at cutoff ODn = 1.0 to 177-183 days at ODn = 2.0. The MDRI values were similar by different methods suggesting coherence of different approaches. Testing for misclassification among long-term infections indicated that overall PFRs were 0.6% to 2.5% at increasing cutoffs of 1.0 to 2.0, respectively. Balancing the need for a longer MDRI and smaller PFR (<2.0%) suggests that a cutoff ODn = 1.5, corresponding to an MDRI of 130 days should be used for cross-sectional application. The MDRI varied among subtypes from 109 days (subtype A&D) to 152 days (subtype C). Conclusions Based on the new data and revised analysis, we recommend an ODn cutoff = 1.5 to classify recent and long-term infections, corresponding to an MDRI of 130 days (118-142). Determination of revised parameters for estimation of HIV-1 incidence should facilitate application of the LAg-Avidity EIA for worldwide use. C1 [Duong, Yen T.; Dobbs, Trudy; Rottinghaus, Erin; Nkengasong, John; Parekh, Bharat S.] Ctr Dis Control & Prevent, Div Global HIV AIDS, Int Lab Branch, Atlanta, GA 30333 USA. [Morgan, Meade; De, Anindya] Ctr Dis Control & Prevent, Div Global HIV AIDS, Epidemiol & Strateg Informat Branch, Atlanta, GA USA. [Kassanjee, Reshma; Welte, Alex] Univ Stellenbosch, South African DST NRF Ctr Excellence Epidemiol Mo, ZA-7600 Stellenbosch, South Africa. [Kassanjee, Reshma] Univ Witwatersrand, Sch Computat & Appl Math, Johannesburg, South Africa. [Curlin, Marcel E.; Kittinunvorakoon, Chonticha; Raengsakulrach, Boonyos; Martin, Michael; Choopanya, Kachit; Vanichseni, Suphak] Thailand Minist Publ Health US CDC Collaborat, Bangkok, Thailand. [Jiang, Yan; Qiu, Maofeng; Yu, Haiying; Hao, Yan] Chinese Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, Natl AIDS Reference Lab, Beijing, Peoples R China. [Shah, Neha] Calif Dept Publ Hlth, Richmond, CA USA. [Linh-Vi Le] Ctr Dis Control & Prevent, Div Global HIV AIDS, Hanoi, Vietnam. [Kim, Andrea A.] CDC Kenya, Nairobi, Kenya. [Tuan Anh Nguyen] Natl Inst Hyg & Epidemiol, Hanoi, Vietnam. [Ampofo, William] Noguchi Mem Inst Med Res, Accra, Ghana. RP Parekh, BS (reprint author), Ctr Dis Control & Prevent, Div Global HIV AIDS, Int Lab Branch, Atlanta, GA 30333 USA. EM bparekh@cdc.gov FU President's Emergency Plan for AIDS Relief (PEPFAR) through the Centers for Disease Control and Prevention (CDC); Bill and Melinda Gates Foundation through Consortium for the Evaluation and Performance of HIV Incidence Assays; HIV Modeling Consortium FX This research has been supported by the President's Emergency Plan for AIDS Relief (PEPFAR) through the Centers for Disease Control and Prevention (CDC). The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the CDC/Agency for Toxic Substances and Disease Registry. AW and RK are grateful for support from the Bill and Melinda Gates Foundation through (and to their colleagues at) the Consortium for the Evaluation and Performance of HIV Incidence Assays, and the HIV Modeling Consortium. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 59 TC 11 Z9 11 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 24 PY 2015 VL 10 IS 2 AR UNSP e0114947 DI 10.1371/journal.pone.0114947 PG 15 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CC9IY UT WOS:000350683900002 PM 25710171 ER PT J AU Cohen, C Walaza, S Moyes, J Groome, M Tempia, S Pretorius, M Hellferscee, O Dawood, H Haffejee, S Variava, E Kahn, K Tshangela, A von Gottberg, A Wolter, N Cohen, AL Kgokong, B Venter, M Madhi, SA AF Cohen, Cheryl Walaza, Sibongile Moyes, Jocelyn Groome, Michelle Tempia, Stefano Pretorius, Marthi Hellferscee, Orienka Dawood, Halima Haffejee, Summaya Variava, Ebrahim Kahn, Kathleen Tshangela, Akhona von Gottberg, Anne Wolter, Nicole Cohen, Adam L. Kgokong, Babatyi Venter, Marietjie Madhi, Shabir A. TI Epidemiology of Severe Acute Respiratory Illness (SARI) among Adults and Children Aged >= 5 Years in a High HIV-Prevalence Setting, 2009-2012 SO PLOS ONE LA English DT Article ID COMMUNITY-ACQUIRED PNEUMONIA; INVASIVE PNEUMOCOCCAL DISEASE; INFECTED ADULTS; SOUTH-AFRICA; STREPTOCOCCUS-PNEUMONIAE; BACTERIAL PNEUMONIA; CONJUGATE VACCINE; RISK-FACTORS; ETIOLOGY; KENYA AB Objective There are few published studies describing severe acute respiratory illness ( SARI) epidemiology amongst older children and adults from high HIV-prevalence settings. We aimed to describe SARI epidemiology amongst individuals aged >= 5 years in South Africa. Methods We conducted prospective surveillance for individuals with SARI from 2009-2012. Using polymerase chain reaction, respiratory samples were tested for ten viruses, and blood for pneumococcal DNA. Cumulative annual SARI incidence was estimated at one site with population denominators. Findings We enrolled 7193 individuals, 9% (621/7067) tested positive for influenza and 9%(600/6519) for pneumococcus. HIV-prevalence was 74% (4663/6334). Among HIV-infected individuals with available data, 41% of 2629 were receiving antiretroviral therapy (ART). The annual SARI hospitalisation incidence ranged from 325-617/100,000 population. HIV-infected individuals experienced a 13-19 times greater SARI incidence than HIV-uninfected individuals (p<0.001). On multivariable analysis, compared to HIV-uninfected individuals, HIV-infected individuals were more likely to be receiving tuberculosis treatment (odds ratio (OR): 1.7; 95% CI:1.1-2.7), have pneumococcal infection (OR 2.4; 95% CI: 1.7-3.3) be hospitalised for >7 days rather than <2 days (OR1.7; 95% CI: 1.2-2.2) and had a higher case-fatality ratio (8% vs 5%; OR1.7; 95% CI: 1.2-2.3), but were less likely to be infected with influenza (OR 0.6; 95% CI: 0.5-0.8). On multivariable analysis, independent risk indicators associated with death included HIV infection (OR 1.8; 95% CI: 1.3-2.4), increasing age-group, receiving mechanical ventilation (OR 6.5; 95% CI: 1.3-32.0) and supplemental-oxygen therapy (OR 2.6; 95% CI: 2.1-3.2). Conclusion The burden of hospitalized SARI amongst individuals aged >= 5 years is high in South Africa. HIV-infected individuals are the most important risk group for SARI hospitalization and mortality in this setting. C1 [Cohen, Cheryl; Walaza, Sibongile; Moyes, Jocelyn; Pretorius, Marthi; Hellferscee, Orienka; Tshangela, Akhona; von Gottberg, Anne; Wolter, Nicole; Kgokong, Babatyi; Venter, Marietjie; Madhi, Shabir A.] Natl Hlth Lab Serv, Ctr Resp Dis & Meningitis, Natl Inst Communicable Dis, Johannesburg, South Africa. [Cohen, Cheryl; Walaza, Sibongile; Moyes, Jocelyn] Univ Witwatersrand, Fac Hlth Sci, Sch Publ Hlth, Johannesburg, South Africa. [Groome, Michelle; von Gottberg, Anne; Wolter, Nicole; Madhi, Shabir A.] Univ Witwatersrand, Fac Hlth Sci, Resp & Meningeal Pathogens Res Unit, Med Res Council, Johannesburg, South Africa. [Groome, Michelle; Madhi, Shabir A.] Univ Witwatersrand, Natl Res Fdn Vaccine Prevent Dis, Dept Sci & Technol, Johannesburg, South Africa. [Tempia, Stefano; Cohen, Adam L.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. [Tempia, Stefano; Cohen, Adam L.] Ctr Dis Control & Prevent South Africa, Influenza Programme, Pretoria, South Africa. [Dawood, Halima] Pietermaritzburg Metropolitan Hosp, Dept Med, Pietermaritzburg, South Africa. [Dawood, Halima] Univ KwaZulu Natal, Pietermaritzburg, South Africa. [Haffejee, Summaya] Univ KwaZulu Natal, Sch Pathol, Pietermaritzburg, South Africa. [Variava, Ebrahim] Klerksdorp Tshepong Hosp, Dept Med, Klerksdorp, South Africa. [Variava, Ebrahim] Univ Witwatersrand, Fac Hlth Sci, Dept Med, Johannesburg, South Africa. [Kahn, Kathleen] Univ Witwatersrand, Fac Hlth Sci, Sch Publ Hlth, MRC Wits Rural Publ Hlth & Hlth Transit Res Unit, Johannesburg, South Africa. [Kahn, Kathleen] Umea Univ, Ctr Global Hlth Res, Umea, Sweden. [Kahn, Kathleen] INDEPTH Network, Accra, Ghana. [Venter, Marietjie] Univ Pretoria, Dept Med Virol, Zoonoses Res Unit, ZA-0002 Pretoria, South Africa. RP Cohen, C (reprint author), Natl Hlth Lab Serv, Ctr Resp Dis & Meningitis, Natl Inst Communicable Dis, Johannesburg, South Africa. EM cherylc@nicd.ac.za; shabirm@nicd.ac.za RI Venter, Marietjie/P-9604-2016 OI Venter, Marietjie/0000-0003-2696-824X FU NICD/NHLS; United States Centers for Disease Control and Prevention (CDC), Atlanta; Pandemic Influenza in South Africa [U51/IP000155-04] FX This study received funding from the NICD/NHLS and was supported in part by funds from the United States Centers for Disease Control and Prevention (CDC), Atlanta, Georgia Preparedness and Response to Avian and Pandemic Influenza in South Africa (Cooperative Agreement Number: U51/IP000155-04). The contents are solely the responsibility of the authors and do not necessarily represent the official views of the CDC. The funders had no role in study design, implementation, NR 39 TC 8 Z9 8 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 23 PY 2015 VL 10 IS 2 AR e0117716 DI 10.1371/journal.pone.0117716 PG 16 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CC9BI UT WOS:000350662100112 PM 25706880 ER PT J AU Kim, JH Roberge, RJ Powell, JB AF Kim, Jung-Hyun Roberge, Raymond J. Powell, Jeffrey B. TI Effect of external airflow resistive load on postural and exercise-associated cardiovascular and pulmonary responses in pregnancy: a case control study SO BMC PREGNANCY AND CHILDBIRTH LA English DT Article DE Pregnancy; External airflow resistive loads; Effects; Cardiovascular; Pulmonary ID STROKE VOLUME; RESPIRATORY PROTECTION; ARTERIAL-PRESSURE; FINGER; HUMANS; IMPACT AB Background: Facial coverings (e.g., balaclavas, niqabs, medical/surgical masks, respirators, etc.), that impose low levels of airflow resistive loads, are worn by millions of pregnant women worldwide, but little data exist addressing their impact on pregnancy-associated cardiovascular and pulmonary responses. Methods: 16 pregnant and 16 non-pregnant women were monitored physiologically (heart rate, blood pressure, mean arterial pressure, total peripheral resistance, stroke volume, cardiac output, oxygen saturation, transcutaneous carbon dioxide, fetal heart rate) and subjectively (exertion) for 1 h of mixed sedentary postural activity (sitting, standing) and moderate exercise (bicycle ergometer) with and without wearing N95 filtering facepiece respirators with filter resistive loads of 94.1 Pa (9.6 mm H2O) - 119.6 Pa (12.2 mm H2O) pressure. Results: The external airflow resistive loads were associated with increases in diastolic pressure (p = 0.004), mean arterial pressure (p = 0.01), and subjective exertion score (p < 0.001) of all study subjects. No significant differences were noted with the external resistive loads between the pregnant and non-pregnant groups for any cardiovascular, pulmonary and subjective variable over 1 h. Conclusions: Low external airflow resistive loads, during combined sedentary postural activity and moderate exercise over 1 h, were associated with increases in the diastolic and mean arterial pressures of all study subjects, but pregnancy itself was not associated with any significant differences in physiologic or subjective responses to the external airway resistive loads utilized in the study. C1 [Kim, Jung-Hyun; Roberge, Raymond J.; Powell, Jeffrey B.] NIOSH, Natl Personal Protect Technol Lab, Ctr Dis Control & Prevent, Pittsburgh, PA 15236 USA. RP Roberge, RJ (reprint author), NIOSH, Natl Personal Protect Technol Lab, Ctr Dis Control & Prevent, 626 Cochrans Mill Rd, Pittsburgh, PA 15236 USA. EM dtn0@cdc.gov NR 38 TC 1 Z9 1 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2393 J9 BMC PREGNANCY CHILDB JI BMC Pregnancy Childbirth PD FEB 22 PY 2015 VL 15 AR 45 DI 10.1186/s12884-015-0474-7 PG 8 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA CC9XQ UT WOS:000350724900001 PM 25886031 ER PT J AU Velandia-Gonzalez, M Trumbo, SP Diaz-Ortega, JL Bravo-Alcantara, P Danovaro-Holliday, MC Dietz, V Ruiz-Matus, C AF Velandia-Gonzalez, Martha Trumbo, Silas Pierson Diaz-Ortega, Jose Luis Bravo-Alcantara, Pamela Danovaro-Holliday, M. Carolina Dietz, Vance Ruiz-Matus, Cuauhtemoc TI Lessons learned from the development of a new methodology to assess missed opportunities for vaccination in Latin America and the Caribbean SO BMC INTERNATIONAL HEALTH AND HUMAN RIGHTS LA English DT Article DE Missed opportunities for vaccination; National immunization programs; Undervaccination; Immunization surveys ID ROUTINE CHILDHOOD VACCINATION; IMMUNIZATION PROGRAMS; COUNTRIES; COVERAGE AB The Pan American Health Organization recently developed a practical guide for evaluating missed opportunities for vaccination among children aged <5 years. A missed opportunity occurs when an individual eligible for vaccination has contact with a health facility and does not receive a needed vaccine, despite having no contraindications. In this article, we discuss the strengths and limitations of this new methodology and present lessons learned from recent studies on undervaccination in Latin America. Our findings should be useful to countries embarking on assessing the magnitude and the causes of missed opportunities for vaccination children experience at health facilities. C1 [Velandia-Gonzalez, Martha; Bravo-Alcantara, Pamela; Danovaro-Holliday, M. Carolina; Ruiz-Matus, Cuauhtemoc] World Hlth Org, Pan Amer Hlth Org, Comprehens Family Immunizat Unit, Washington, DC 20037 USA. [Trumbo, Silas Pierson] Vanderbilt Univ Sch Med, Nashville, TN USA. [Diaz-Ortega, Jose Luis] Natl Inst Publ Hlth INSP, Ctr Res Infect Dis CISEI Spanish, Mexico City, DF, Mexico. [Dietz, Vance] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Velandia-Gonzalez, M (reprint author), World Hlth Org, Pan Amer Hlth Org, Comprehens Family Immunizat Unit, 525 23rd St NW, Washington, DC 20037 USA. EM velandiam@paho.org OI Diaz-Ortega, Jose-Luis/0000-0003-1047-3808 FU World Health Organization [001] NR 32 TC 2 Z9 2 U1 1 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1472-698X J9 BMC INT HEALTH HUM R JI BMC Int. Health Hum. Rights. PD FEB 21 PY 2015 VL 15 AR 5 DI 10.1186/s12914-015-0043-1 PG 8 WC Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA CD1SG UT WOS:000350854000001 PM 25889653 ER PT J AU Cao, XF Lin, HX Muskhelishvili, L Latendresse, J Richter, P Heflich, RH AF Cao, Xuefei Lin, Haixia Muskhelishvili, Levan Latendresse, John Richter, Patricia Heflich, Robert H. TI Tight junction disruption by cadmium in an in vitro human airway tissue model SO RESPIRATORY RESEARCH LA English DT Article DE Cadmium; Airway air-liquid-interface (ALI) culture; Tight junction; Occludin phosphorylation; Intracellular junctional interacting proteins ID PROTEIN-KINASE-C; TYROSINE PHOSPHORYLATION; EPITHELIAL-CELLS; OCCLUDIN; ZO-1; CARCINOGENESIS; LOCALIZATION; POPULATION; EXPRESSION; EXPOSURE AB Background: The cadmium (Cd) present in air pollutants and cigarette smoke has the potential of causing multiple adverse health outcomes involving damage to pulmonary and cardiovascular tissue. Injury to pulmonary epithelium may include alterations in tight junction (TJ) integrity, resulting in impaired epithelial barrier function and enhanced penetration of chemicals and biomolecules. Herein, we investigated mechanisms involved in the disruption of TJ integrity by Cd exposure using an in vitro human air-liquid-interface (ALI) airway tissue model derived from normal primary human bronchial epithelial cells. Methods: ALI cultures were exposed to noncytotoxic doses of CdCl2 basolaterally and TJ integrity was measured by Trans-Epithelial Electrical Resistance (TEER) and immunofluorescence staining with TJ markers. PCR array analysis was used to identify genes involved with TJ collapse. To explore the involvement of kinase signaling pathways, cultures were treated with CdCl2 in the presence of kinase inhibitors specific for cellular Src or Protein Kinase C (PKC). Results: Noncytotoxic doses of CdCl2 resulted in the collapse of barrier function, as demonstrated by TEER measurements and Zonula occludens-1 (ZO-1) and occludin staining. CdCl2 exposure altered the expression of several groups of genes encoding proteins involved in TJ homeostasis. In particular, down-regulation of select junction- interacting proteins suggested that a possible mechanism for Cd toxicity involves disruption of the peripheral junctional complexes implicated in connecting membrane-bound TJ components to the actin cytoskeleton. Inhibition of kinase signaling using inhibitors specific for cellular Src or PKC preserved the integrity of TJs, possibly by preventing occludin tyrosine hyperphosphorylation, rather than reversing the down-regulation of the junction interacting proteins. Conclusions: Our findings indicate that acute doses of Cd likely disrupt TJ integrity in human ALI airway cultures both through occludin hyperphosphorylation via kinase activation and by direct disruption of the junction-interacting complex. C1 [Cao, Xuefei; Lin, Haixia] US FDA, Natl Ctr Toxicol Res, Jefferson, AR 72205 USA. [Muskhelishvili, Levan; Latendresse, John] Toxicol Pathol Associates, Jefferson, AR 72079 USA. [Richter, Patricia] US Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Heflich, Robert H.] Div Genet & Mol Toxicol, Jefferson, AR 72079 USA. RP Heflich, RH (reprint author), Div Genet & Mol Toxicol, 3900 NCTR Rd, Jefferson, AR 72079 USA. EM robert.heflich@fda.hhs.gov FU U.S. Food and Drug Administration through Center for Tobacco Products; Oak Ridge Institute for Science and Education FX This work is supported by U.S. Food and Drug Administration funding through the Center for Tobacco Products (this study was conducted between March and August of 2013). H.L was supported by a post-doctoral fellowship through the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the U.S. Food and Drug Administration. NR 34 TC 6 Z9 7 U1 0 U2 9 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1465-993X EI 1465-9921 J9 RESP RES JI Respir. Res. PD FEB 21 PY 2015 VL 16 AR 30 DI 10.1186/s12931-015-0191-9 PG 14 WC Respiratory System SC Respiratory System GA CD0VA UT WOS:000350790800001 PM 25851441 ER PT J AU Petersen, BW Damon, IK Pertowski, CA Meaney-Delman, D Guarnizo, JT Beigi, RH Edwards, KM Fisher, MC Frey, SE Lynfield, R Willoughby, RE AF Petersen, Brett W. Damon, Inger K. Pertowski, Carol A. Meaney-Delman, Dana Guarnizo, Julie T. Beigi, Richard H. Edwards, Kathryn M. Fisher, Margaret C. Frey, Sharon E. Lynfield, Ruth Willoughby, Rodney E. TI Clinical Guidance for Smallpox Vaccine Use in a Postevent Vaccination Program SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID JANUARY-OCTOBER 2003; UNITED-STATES; INTRAFAMILIAL TRANSMISSION; CARDIAC COMPLICATIONS; CONTROLLED-TRIAL; IMMUNOGENICITY; SAFETY; VIRUS; HEALTH; ANKARA AB This report outlines recommendations for the clinical use of the three smallpox vaccines stored in the U.S. Strategic National Stockpile for persons who are exposed to smallpox virus or at high risk for smallpox infection during a postevent vaccination program following an intentional or accidental release of the virus. No absolute contraindications exist for smallpox vaccination in a postevent setting. However, several relative contraindications exist among persons with certain medical conditions. CDC recommendations for smallpox vaccine use were developed in consideration of the risk for smallpox infection, risk for an adverse event following vaccination, and benefit from vaccination. Smallpox vaccines are made from live vaccinia viruses that protect against smallpox disease. They do not contain variola virus, the causative agent of smallpox. The three smallpox vaccines stockpiled are ACAM2000, Aventis Pasteur Smallpox Vaccine (APSV), and Imvamune. Surveillance and containment activities including vaccination with replication-competent smallpox vaccine (i.e., vaccine viruses capable of replicating in mammalian cells such as ACAM2000 and APSO will be the primary response strategy for achieving epidemic control. Persons exposed to smallpox virus are at high risk for developing and transmitting smallpox and should be vaccinated with a replication-competent smallpox vaccine unless severely immunodeficient. Because of a high likelihood of a poor immune response and an increased risk for adverse events, smallpox vaccination should be avoided in persons with severe immunodeficiency who are not expected to benefit from vaccine, including bone marrow transplant recipients within 4 months of transplantation, persons infected with HIV with CD4 cell counts <50 cells/mm(3), and persons with severe combined immunodeficiency, complete DiGeorge syndrome, and other severely immunocompromised states requiring isolation. If antivirals are not immediately available, it is reasonable to consider the use of Imvamune in the setting of a smallpox virus exposure in persons with severe immunodeficiency. Persons without a known smallpox virus exposure might still be at high risk for developing smallpox infection depending on the magnitude of the outbreak and the effectiveness of the public health response. Such persons will be defined by public health authorities and should be screened for relative contraindications to smallpox vaccination. Relative contraindications include atopic dermatitis (eczema), HIV infection (CD4 cell counts of 50-199 cells/mm(3)), other immunocompromised states, and vaccine or vaccine-component allergies. Persons with relative contraindications should be vaccinated with Imvamune when available and authorized for use by the Food and Drug Administration. These recommendations will be updated as new data on smallpox vaccines become available and further clinical guidance for other medical countermeasures including antivirals is developed. C1 [Petersen, Brett W.; Damon, Inger K.] CDC, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Pertowski, Carol A.] CDC, Off Director, Off Publ Hlth Preparedness & Response, Atlanta, GA 30333 USA. [Meaney-Delman, Dana] CDC, Off Director, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Guarnizo, Julie T.] CDC, Div Preparedness & Emerging Infect, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Beigi, Richard H.] Univ Pittsburgh, Magee Womens Hosp, Med Ctr, Pittsburgh, PA 15213 USA. [Edwards, Kathryn M.] Vanderbilt Univ, Vanderbilt Vaccine Res Program, Nashville, TN 37235 USA. [Fisher, Margaret C.] Barnabas Hlth, Unterberg Childrens Hosp, Monmouth Med Ctr, Long Branch, NJ USA. [Frey, Sharon E.] St Louis Univ, Sch Med, Ctr Vaccine Dev, St Louis, MO USA. [Lynfield, Ruth] Minnesota Dept Hlth, St Paul, MN USA. [Willoughby, Rodney E.] Med Coll Wisconsin, Childrens Hosp Wisconsin, Milwaukee, WI 53226 USA. RP Petersen, BW (reprint author), CDC, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. EM ige3@cdc.gov NR 75 TC 0 Z9 0 U1 1 U2 4 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 20 PY 2015 VL 64 IS 2 SU S BP 1 EP 26 PG 26 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CD5IA UT WOS:000351120000001 ER PT J AU Petersen, BW Damon, IK Pertowski, CA Meaney-Delman, D Guarnizo, JT Beigi, RH Edwards, KM Fisher, MC Frey, SE Lynfield, R Willoughby, RE AF Petersen, Brett W. Damon, Inger K. Pertowski, Carol A. Meaney-Delman, Dana Guarnizo, Julie T. Beigi, Richard H. Edwards, Kathryn M. Fisher, Margaret C. Frey, Sharon E. Lynfield, Ruth Willoughby, Rodney E. TI Clinical Guidance for Smallpox Vaccine Use in a Postevent Vaccination Program SO MMWR RECOMMENDATIONS AND REPORTS LA English DT Article ID JANUARY-OCTOBER 2003; UNITED-STATES; INTRAFAMILIAL TRANSMISSION; CARDIAC COMPLICATIONS; CONTROLLED-TRIAL; IMMUNOGENICITY; SAFETY; VIRUS; HEALTH; ANKARA AB This report outlines recommendations for the clinical use of the three smallpox vaccines stored in the U.S. Strategic National Stockpile for persons who are exposed to smallpox virus or at high risk for smallpox infection during a postevent vaccination program following an intentional or accidental release of the virus. No absolute contraindications exist for smallpox vaccination in a postevent setting. However, several relative contraindications exist among persons with certain medical conditions. CDC recommendations for smallpox vaccine use were developed in consideration of the risk for smallpox infection, risk for an adverse event following vaccination, and benefit from vaccination. Smallpox vaccines are made from live vaccinia viruses that protect against smallpox disease. They do not contain variola virus, the causative agent of smallpox. The three smallpox vaccines stockpiled are ACAM2000, Aventis Pasteur Smallpox Vaccine (APSV), and Imvamune. Surveillance and containment activities including vaccination with replication-competent smallpox vaccine (i.e., vaccine viruses capable of replicating in mammalian cells such as ACAM2000 and APSV) will be the primary response strategy for achieving epidemic control. Persons exposed to smallpox virus are at high risk for developing and transmitting smallpox and should be vaccinated with a replication-competent smallpox vaccine unless severely immunodeficient. Because of a high likelihood of a poor immune response and an increased risk for adverse events, smallpox vaccination should be avoided in persons with severe immunodeficiency who are not expected to benefit from vaccine, including bone marrow transplant recipients within 4 months of transplantation, persons infected with HIV with CD4 cell counts < 50 cells/mm3, and persons with severe combined immunodeficiency, complete DiGeorge syndrome, and other severely immunocompromised states requiring isolation. If antivirals are not immediately available, it is reasonable to consider the use of Imvamune in the setting of a smallpox virus exposure in persons with severe immunodeficiency. Persons without a known smallpox virus exposure might still be at high risk for developing smallpox infection depending on the magnitude of the outbreak and the effectiveness of the public health response. Such persons will be defined by public health authorities and should be screened for relative contraindications to smallpox vaccination. Relative contraindications include atopic dermatitis (eczema), HIV infection (CD4 cell counts of 50-199 cells/mm3), other immunocompromised states, and vaccine or vaccine-component allergies. Persons with relative contraindications should be vaccinated with Imvamune when available and authorized for use by the Food and Drug Administration. These recommendations will be updated as new data on smallpox vaccines become available and further clinical guidance for other medical countermeasures including antivirals is developed. C1 [Petersen, Brett W.; Damon, Inger K.] CDC, Natl Ctr Emerging & Zoonot Infect Dis, Div High Consequence Pathogens & Pathol, Atlanta, GA 30333 USA. [Pertowski, Carol A.] CDC, Off Publ Hlth Preparedness & Response, Off Director, Atlanta, GA 30333 USA. [Meaney-Delman, Dana] CDC, Natl Ctr Emerging & Zoonot Infect Dis, Off Director, Atlanta, GA 30333 USA. [Guarnizo, Julie T.] CDC, Natl Ctr Emerging & Zoonot Infect Dis, Div Preparedness & Emerging Infect, Atlanta, GA 30333 USA. [Beigi, Richard H.] Univ Penn, Magee Womens Hosp, Med Ctr, Pittsburgh, PA USA. [Edwards, Kathryn M.] Vanderbilt Univ, Vanderbilt Vaccine Res Program, Nashville, TN 37235 USA. [Fisher, Margaret C.] Unterberg Childrens Hosp, Monmouth Med Ctr, Barnabas Hlth, Long Branch, NJ USA. [Frey, Sharon E.] St Louis Univ, Sch Med, Ctr Vaccine Dev, St Louis, MO 63103 USA. [Lynfield, Ruth] Minnesota Dept Hlth, St Paul, MN USA. [Willoughby, Rodney E.] Childrens Hosp Wisconsin, Med Coll Wisconsin, Milwaukee, WI 53201 USA. RP Petersen, BW (reprint author), CDC, Natl Ctr Emerging & Zoonot Infect Dis, Div High Consequence Pathogens & Pathol, Atlanta, GA 30333 USA. EM ige3@cdc.gov NR 75 TC 4 Z9 4 U1 1 U2 4 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1057-5987 EI 1545-8601 J9 MMWR RECOMM REP JI MMWR Recomm. Rep. PD FEB 20 PY 2015 VL 64 IS 2 BP 1 EP 26 PG 26 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CE8MQ UT WOS:000352097200001 ER PT J AU Domercant, JW Guillaume, FD Marston, BJ Lowrance, DW AF Domercant, J. Wysler Guillaume, Florence D. Marston, Barbara J. Lowrance, David W. TI Update on Progress in Selected Public Health Programs After the 2010 Earthquake and Cholera Epidemic - Haiti, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Domercant, J. Wysler; Marston, Barbara J.; Lowrance, David W.] CDC, Ctr Global Hlth, Div Global Hlth Protect, Atlanta, GA 30333 USA. EM bmarston@cdc.gov NR 15 TC 4 Z9 4 U1 2 U2 16 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 20 PY 2015 VL 64 IS 6 BP 137 EP 140 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CB7VT UT WOS:000349837300001 PM 25695317 ER PT J AU Meiman, J Anderson, H Tomasallo, C AF Meiman, Jon Anderson, Henry Tomasallo, Carrie TI Hypothermia-Related Deaths - Wisconsin, 2014, and United States, 2003-2013 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Meiman, Jon] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Meiman, Jon; Anderson, Henry; Tomasallo, Carrie] Bur Environm & Occupat Hlth, Wisconsin Div Publ Hlth, Madison, WI USA. RP Meiman, J (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM xdf5@cdc.gov NR 5 TC 4 Z9 4 U1 0 U2 2 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 20 PY 2015 VL 64 IS 6 BP 141 EP 143 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CB7VT UT WOS:000349837300002 PM 25695318 ER PT J AU Angelo, KM Chu, A Anand, M Nguyen, TA Bottichio, L Wise, M Williams, I Seelman, S Bell, R Fatica, M Lance, S Baldwin, D Shannon, K Lee, H Trees, E Strain, E Gieraltowski, L AF Angelo, Kristina M. Chu, Alvina Anand, Madhu Thai-An Nguyen Bottichio, Lyndsay Wise, Matthew Williams, Ian Seelman, Sharon Bell, Rebecca Fatica, Marianne Lance, Susan Baldwin, Deanna Shannon, Kyle Lee, Hannah Trees, Eija Strain, Errol Gieraltowski, Laura TI Outbreak of Salmonella Newport Infections Linked to Cucumbers - United States, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Angelo, Kristina M.] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Angelo, Kristina M.; Thai-An Nguyen; Bottichio, Lyndsay; Wise, Matthew; Williams, Ian; Trees, Eija; Gieraltowski, Laura] CDC, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Chu, Alvina; Shannon, Kyle; Lee, Hannah] Maryland Dept Hlth & Mental Hyg, Baltimore, MD 21201 USA. [Anand, Madhu] New York State Dept Hlth, Albany, NY 12237 USA. [Seelman, Sharon; Bell, Rebecca; Fatica, Marianne; Lance, Susan; Strain, Errol] US FDA, Rockville, MD 20857 USA. [Baldwin, Deanna] Maryland Dept Agr, College Pk, MD USA. RP Angelo, KM (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM kangelo@cdc.gov NR 3 TC 16 Z9 17 U1 1 U2 19 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 20 PY 2015 VL 64 IS 6 BP 144 EP 147 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CB7VT UT WOS:000349837300003 PM 25695319 ER PT J AU Bohm, SR Berger, KW Hackert, PB Renas, R Brunette, S Parker, N Padro, C Hocking, A Hedemark, M Edwards, R Bush, RL Khudyakov, Y Nelson, NP Teshale, EH AF Bohm, Susan R. Berger, Keira Wickliffe Hackert, Pamela B. Renas, Richard Brunette, Suzanne Parker, Nicole Padro, Carolyn Hocking, Anne Hedemark, Mary Edwards, Renai Bush, Russell L. Khudyakov, Yury Nelson, Noele P. Teshale, Eyasu H. TI Hepatitis A Outbreak Among Adults with Developmental Disabilities in Group Homes - Michigan, 2013 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Bohm, Susan R.; Berger, Keira Wickliffe] CDC, Div Communicable Dis, Michigan Dept Community Hlth, Natl Ctr HIV AIDS Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA. [Hackert, Pamela B.] CDC, Med Serv, Oakland Cty Hlth Div, Natl Ctr HIV AIDS Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA. [Renas, Richard; Brunette, Suzanne; Parker, Nicole; Padro, Carolyn; Hocking, Anne] CDC, Communicable Dis Unit, Oakland Cty Hlth Div, Natl Ctr HIV AIDS Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA. [Hedemark, Mary; Edwards, Renai] CDC, Macomb Cty Hlth Dept, Natl Ctr HIV AIDS Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA. [Bush, Russell L.] CDC, Tuscola Cty Hlth Dept, Natl Ctr HIV AIDS Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA. [Khudyakov, Yury; Nelson, Noele P.; Teshale, Eyasu H.] CDC, Div Viral Hepatitis, Natl Ctr HIV AIDS Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA. RP Bohm, SR (reprint author), CDC, Div Communicable Dis, Michigan Dept Community Hlth, Natl Ctr HIV AIDS Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA. EM bohms@michigan.gov NR 6 TC 3 Z9 3 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 20 PY 2015 VL 64 IS 6 BP 148 EP 152 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CB7VT UT WOS:000349837300004 PM 25695320 ER PT J AU Vallabhaneni, S Walker, TA Lockhart, SR Ng, D Chiller, T Melchreit, R Brandt, ME Smith, RM AF Vallabhaneni, Snigdha Walker, Tiffany A. Lockhart, Shawn R. Ng, Dianna Chiller, Tom Melchreit, Richard Brandt, Mary E. Smith, Rachel M. CA Infect Dis Pathology Branch TI Fatal Gastrointestinal Mucormycosis in a Premature Infant Associated with a Contaminated Dietary Supplement - Connecticut, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Vallabhaneni, Snigdha; Walker, Tiffany A.; Lockhart, Shawn R.; Chiller, Tom; Brandt, Mary E.; Smith, Rachel M.] CDC, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Ng, Dianna; Infect Dis Pathology Branch] CDC, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Melchreit, Richard] Connecticut Dept Publ Hlth, Hartford, CT USA. RP Smith, RM (reprint author), CDC, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. EM rmsmith@cdc.gov NR 6 TC 15 Z9 15 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 20 PY 2015 VL 64 IS 6 BP 155 EP 156 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CB7VT UT WOS:000349837300006 PM 25695322 ER PT J AU Kawamoto, M Page, E AF Kawamoto, Melody Page, Elena TI Use of Unvalidated Urine Mycotoxin Tests for the Clinical Diagnosis of Illness - United States, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Kawamoto, Melody; Page, Elena] CDC, Div Surveillance Hazard Evaluat & Field Studies, Natl Inst Occupat Safety & Hlth, Atlanta, GA 30333 USA. RP Page, E (reprint author), CDC, Div Surveillance Hazard Evaluat & Field Studies, Natl Inst Occupat Safety & Hlth, Atlanta, GA 30333 USA. EM epage@cdc.gov NR 6 TC 0 Z9 0 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 20 PY 2015 VL 64 IS 6 BP 157 EP 158 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CB7VT UT WOS:000349837300007 PM 25695323 ER PT J AU Nett, RJ Witte, TK Holzbauer, SM Elchos, BL Campagnolo, ER Musgrave, KJ Carter, KK Kurkjian, KM Vanicek, C O'Leary, DR Pride, KR Funk, RH AF Nett, Randall J. Witte, Tracy K. Holzbauer, Stacy M. Elchos, Brigid L. Campagnolo, Enzo R. Musgrave, Karl J. Carter, Kris K. Kurkjian, Katie M. Vanicek, Cole O'Leary, Daniel R. Pride, Kerry R. Funk, Renee H. TI Notes from the Field: Prevalence of Risk Factors for Suicide Among Veterinarians - United States, 2014 (vol 64, pg 131, 2015) SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Correction C1 [Nett, Randall J.; Holzbauer, Stacy M.; Campagnolo, Enzo R.; Carter, Kris K.; Kurkjian, Katie M.; O'Leary, Daniel R.] CDC, Div State & Local Readiness, Off Publ Hlth Preparedness & Response, Atlanta, GA 30333 USA. [Nett, Randall J.; Pride, Kerry R.] Montana Dept Publ Hlth & Human Serv, Helena, MT USA. [Witte, Tracy K.] Auburn Univ, Dept Psychol, Auburn, AL 36849 USA. [Holzbauer, Stacy M.] Minnesota Dept Hlth, Minneapolis, MN 55414 USA. [Elchos, Brigid L.] Mississippi Board Anim Hlth, Jackson, MS USA. [Campagnolo, Enzo R.] Penn Dept Hlth, Harrisburg, PA 17108 USA. [Musgrave, Karl J.; O'Leary, Daniel R.] Wyoming Dept Hlth, Cheyenne, WY USA. [Carter, Kris K.] Idaho Dept Hlth & Welf, Boise, ID USA. [Kurkjian, Katie M.] Virginia Dept Hlth, Charlottesville, VA USA. [Vanicek, Cole] Nebraska Dept Hlth & Human Serv, Lincoln, NE USA. [Funk, Renee H.] CDC, Emergency Preparedness & Response Off, Natl Inst Occupat Safety & Hlth, Atlanta, GA 30333 USA. RP Nett, RJ (reprint author), CDC, Div State & Local Readiness, Off Publ Hlth Preparedness & Response, Atlanta, GA 30333 USA. EM rnett@cdc.gov NR 1 TC 0 Z9 0 U1 1 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 20 PY 2015 VL 64 IS 6 BP 159 EP 159 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CB7VT UT WOS:000349837300008 ER PT J AU Bruxvoort, K Kalolella, A Cairns, M Festo, C Kenani, M Lyaruu, P Kachur, SP Schellenberg, D Goodman, C AF Bruxvoort, Katia Kalolella, Admirabilis Cairns, Matthew Festo, Charles Kenani, Mitya Lyaruu, Peter Kachur, S. Patrick Schellenberg, David Goodman, Catherine TI Are Tanzanian patients attending public facilities or private retailers more likely to adhere to artemisinin-based combination therapy? SO MALARIA JOURNAL LA English DT Article DE Malaria; ACT; Adherence; Public health facilities; Private sector; ADDOs ID SUB-SAHARAN AFRICA; ARTEMETHER-LUMEFANTRINE; HOLOENDEMIC REGION; MALARIA TREATMENT; DRUG-RESISTANCE; RURAL-COMMUNITY; FEVER TREATMENT; WESTERN KENYA; ACCESS; POPULATION AB Background: Artemisinin combination therapy (ACT) is first-line treatment for malaria in most endemic countries and is increasingly available in the private sector. Most studies on ACT adherence have been conducted in the public sector, with minimal data from private retailers. Methods: Parallel studies were conducted in Tanzania, in which patients obtaining artemether-lumefantrine (AL) at 40 randomly selected public health facilities and 37 accredited drug dispensing outlets (ADDOs) were visited at home and questioned about doses taken. The effect of sector on adherence, controlling for potential confounders was assessed using logistic regression with a random effect for outlet. Results: Of 572 health facility patients and 450 ADDO patients, 74.5% (95% CI: 69.8, 78.8) and 69.8% (95% CI: 64.6, 74.5), respectively, completed treatment and 46.0% (95% CI: 40.9, 51.2) and 34.8% (95% CI: 30.1, 39.8) took each dose at the correct time ('timely completion'). ADDO patients were wealthier, more educated, older, sought care later in the day, and were less likely to test positive for malaria than health facility patients. Controlling for patient characteristics, the adjusted odds of completed treatment and of timely completion for ADDO patients were 0.65 (95% CI: 0.43, 1.00) and 0.69 (95% CI: 0.47, 1.01) times that of health facility patients. Higher socio-economic status was associated with both adherence measures. Higher education was associated with completed treatment (adjusted OR = 1.68, 95% CI: 1.20, 2.36); obtaining AL in the evening was associated with timely completion (adjusted OR = 0.35, 95% CI: 0.19, 0.64). Factors associated with adherence in each sector were examined separately. In both sectors, recalling correct instructions was positively associated with both adherence measures. In health facility patients, but not ADDO patients, taking the first dose of AL at the outlet was associated with timely completion (adjusted OR = 2.11, 95% CI: 1.46, 3.04). Conclusion: When controlling for patient characteristics, there was some evidence that the adjusted odds of adherence for ADDO patients was lower than that for public health facility patients. Better understanding is needed of which patient care aspects are most important for adherence, including the role of effective provision of advice. C1 [Bruxvoort, Katia; Cairns, Matthew; Schellenberg, David; Goodman, Catherine] London Sch Hyg & Trop Med, London WC1, England. [Kalolella, Admirabilis; Festo, Charles; Kenani, Mitya; Lyaruu, Peter] Ifakara Hlth Inst, Dar Es Salaam, Tanzania. [Kachur, S. Patrick] Ctr Dis Control & Prevent, Malaria Branch, Atlanta, GA USA. RP Bruxvoort, K (reprint author), London Sch Hyg & Trop Med, London WC1, England. EM katia.bruxvoort@lshtm.ac.uk FU Bill and Melinda Gates Foundation; Population Health Scientist Fellowship from the UK Medical Research Council FX The authors would like to acknowledge Dr Frank Mayaya for insights and leadership in the field. The study was funded by the Bill and Melinda Gates Foundation, through a grant to the ACT Consortium. MC is supported by a Population Health Scientist Fellowship from the UK Medical Research Council. KB, MC, DS, and CG are members of the LSHTM Malaria Centre. NR 37 TC 2 Z9 2 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD FEB 19 PY 2015 VL 14 AR 87 DI 10.1186/s12936-015-0602-x PG 12 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CB9BQ UT WOS:000349926700001 PM 25889767 ER PT J AU Masanja, IM McMorrow, ML Maganga, MB Sumari, D Udhayakumar, V McElroy, PD Kachur, SP Lucchi, NW AF Masanja, Irene M. McMorrow, Meredith L. Maganga, Mussa B. Sumari, Debora Udhayakumar, Venkatachalam McElroy, Peter D. Kachur, S. Patrick Lucchi, Naomi W. TI Quality assurance of malaria rapid diagnostic tests used for routine patient care in rural Tanzania: microscopy versus real-time polymerase chain reaction SO MALARIA JOURNAL LA English DT Article DE Rapid diagnostic test (RDT); Microscopy; qPCR; Quality assurance (QA); Routine malaria tests ID PLASMODIUM-FALCIPARUM MALARIA; TRANSMISSION; MISDIAGNOSIS; PERFORMANCE; TRAVELERS; UGANDA; ZAMBIA; THICK; HRP-2; AREA AB Background: The World Health Organization (WHO) recommends parasitologic confirmation of suspected malaria cases before treatment. Due to the limited availability of quality microscopy services, this recommendation has become scalable following increased use of antigen-detecting malaria rapid diagnostic tests (RDTs) in many malaria-endemic countries. This study was carried out to monitor quality of RDT performance in selected health facilities using two quality assurance (QA) methods: reference microscopy and detection of parasite DNA by real-time quantitative polymerase chain reaction (qPCR) on dried blood spots (DBS). Methods: Blood samples for QA were collected from patients undergoing RDT for diagnostic confirmation of malaria during two to three consecutive days per month in 12 health facilities in rural Tanzania. Stained blood smears (BS) were first examined at the district hospitals (BS1) and then at a reference laboratory (BS2). Discordant BS1 and BS2 results prompted a third examination. Molecular analysis was carried out at the Ifakara Health Institute laboratory in Bagamoyo. Results: Malaria RDTs had a higher positivity rate (6.5%) than qPCR (4.2%) or microscopy (2.9% for BS1 and 2.5% for BS2). Poor correlation was observed between RDT and BS results: BS1 (K = 0.5), BS2 (K = 0.43) and qPCR (K = 0.45), challenging the utility of these tests for RDT QA. In addition, many challenges related to qPCR processing were recorded and long delays in obtaining QA test results for both microscopy and qPCR. Conclusions: Overall there was limited agreement among the three diagnostic approaches and neither microscopy nor qPCR appear to be good QA options for RDTs under field conditions. C1 [Masanja, Irene M.; Maganga, Mussa B.; Sumari, Debora] Ifakara Hlth Inst, Dar Es Salaam, Tanzania. [McMorrow, Meredith L.; Udhayakumar, Venkatachalam; McElroy, Peter D.; Kachur, S. Patrick; Lucchi, Naomi W.] US Ctr Dis Control & Prevent, Ctr Global Hlth, Malaria Branch, Atlanta, GA USA. [McMorrow, Meredith L.; Kachur, S. Patrick] US PHS, Rockville, MD USA. [McElroy, Peter D.] US President Malaria Initiat PMI, Dar Es Salaam, Tanzania. RP Masanja, IM (reprint author), Ifakara Hlth Inst, POB 78373, Dar Es Salaam, Tanzania. EM imasanja@ihi.or.tz FU American people (USAID); US President's Malaria Initiative FX This work was made possible by the generous support from the American people (USAID) and the US President's Malaria Initiative. Conclusions reached in this report are those made by the investigators (authors) and do not reflect views of the USAID, PMI or the US Government, or their Institutions. The authors would like to acknowledge immense support and contribution made by the National Malaria Control programme of the Tanzanian Ministry of Health and Social Welfare (case management cell); District Medical Officers and the Council Health Management Teams of Iringa and Mufindi District Councils; Clinician in-charge and health workers in 12 participating health facilities; IHI drivers; field workers for health workers' qualitative enquiry; US President's Malaria Initiative-Tanzania Office: IHI administration, data unit and procurement unit(s), laboratory technician of Iringa Regional Hospital, Iringa District Council laboratory supervisor and Mufindi laboratory technicians at Mafinga Hospital. NR 42 TC 2 Z9 2 U1 1 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD FEB 19 PY 2015 VL 14 AR 85 DI 10.1186/s12936-015-0597-3 PG 7 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CB7IG UT WOS:000349799600001 PM 25889613 ER PT J AU Schuchat, A AF Schuchat, Anne TI HPV "Coverage" SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Editorial Material ID HUMAN-PAPILLOMAVIRUS; VACCINATION COVERAGE; ADOLESCENTS; STATES C1 Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. RP Schuchat, A (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. NR 8 TC 13 Z9 13 U1 0 U2 5 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD FEB 19 PY 2015 VL 372 IS 8 BP 775 EP 776 DI 10.1056/NEJMe1415742 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA CB7PB UT WOS:000349818700014 PM 25693018 ER PT J AU Nadol, P O'connor, S Duong, H Le, LVN Thang, PH Tram, TH Ha, HTT Mcconnell, MS Partridge, J Kaldor, J Law, M Nguyen, TA AF Nadol, Patrick O'connor, Siobhan Duong, Hao Le, Linh-Vi N. Pham Hong Thang Tran Hong Tram Hoang Thi Thanh Ha Mcconnell, Michelle S. Partridge, Jeff Kaldor, John Law, Matthew Tuan Anh Nguyen TI Findings from Integrated Behavioral and Biologic Survey among Males Who Inject Drugs (MWID) - Vietnam, 2009-2010: Evidence of the Need for an Integrated Response to HIV, Hepatitis B Virus, and Hepatitis C Virus SO PLOS ONE LA English DT Article ID GLOBAL EPIDEMIOLOGY; COINFECTION; INFECTION; PEOPLE; USERS; RISK AB Introduction Given the overlapping modes of transmission of HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV), understanding the burden and relationship of these infections is critical for an effective response. Representative data on these infections among males who inject drugs (MWID), the key high-risk population for HIV in Vietnam, are currently lacking. Methods Data and stored specimens from Vietnam's 2009-2010 Integrated Biologic and Behavioral Survey, a cross-sectional study among high-risk populations, were used for this analysis. Plasma samples were tested for HIV, HBV, and HCV using commercial assays. A questionnaire was administered to provide demographic, behavior, and service-uptake information. Provincial-level analyses were conducted to profile MWID enrollees and to provide estimates on the prevalence of HIV, HBV, and HCV infection. Results Among 3010 MWID sampled across 10 provinces, the median (range) HIV prevalence was 28.1% (1.0%-55.5%). Median prevalence for current HBV infection (HBsAg+) was 14.1% (11.7%-28.0%), for previous exposure to HBV (total anti-HBc+) was 71.4% (49.9%-83.1%), and for current or past HCV infection (HCV Ag/Ab+) was 53.8%(10.9%-80.8%). In adjusted analysis, HBsAg+ (aOR: 2.09, 1.01-4.34) and HCV Ag/Ab+ (aOR: 19.58, 13.07-29.33) status were significantly associated with HIV infection; the association with total anti-HBc+ approached significance (aOR: 1.29, 0.99-1.68). Conclusion The prevalence and association between HIV, HBV, and HCV are high among MWID in Vietnam. These findings indicate the need for integrated policies and practice that for the surveillance, prevention, screening, and treatment of both HIV and viral hepatitis among MWID in Vietnam. C1 [Nadol, Patrick; Duong, Hao; Le, Linh-Vi N.; Mcconnell, Michelle S.] US Ctr Dis Control & Prevent, Div Global HIV AIDS, Hanoi, Vietnam. [Nadol, Patrick; Kaldor, John; Law, Matthew] Univ New S Wales, Kirby Inst Infect & Immun, Sydney, NSW, Australia. [O'connor, Siobhan] US Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA USA. [Pham Hong Thang; Tran Hong Tram; Hoang Thi Thanh Ha; Tuan Anh Nguyen] Natl Inst Hyg & Epidemiol, Hanoi, Vietnam. [Partridge, Jeff] US Ctr Dis Control & Prevent, Div Influenza Control, Atlanta, GA USA. RP Nadol, P (reprint author), US Ctr Dis Control & Prevent, Div Global HIV AIDS, Hanoi, Vietnam. EM pen5@cdc.gov FU President's Emergency Plan for AIDS Relief (PEPFAR) through the U.S. Centers for Disease Control and Prevention (CDC) [5U2GGH000116] FX The research has been supported by the President's Emergency Plan for AIDS Relief (PEPFAR) through the U.S. Centers for Disease Control and Prevention (CDC) under the terms of 5U2GGH000116. CDC staff were directly engaged in the study design, analysis, decision to publish, and preparation of the manuscript. NR 44 TC 3 Z9 3 U1 1 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 18 PY 2015 VL 10 IS 2 AR e0118304 DI 10.1371/journal.pone.0118304 PG 17 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CC0WZ UT WOS:000350061500115 PM 25692469 ER PT J AU Kalkowska, DA Tebbens, RJD Pallansch, MA Cochi, SL Wassilak, SGF Thompson, KM AF Kalkowska, Dominika A. Tebbens, Radboud J. Duintjer Pallansch, Mark A. Cochi, Stephen L. Wassilak, Steven G. F. Thompson, Kimberly M. TI Modeling undetected live poliovirus circulation after apparent interruption of transmission: implications for surveillance and vaccination SO BMC INFECTIOUS DISEASES LA English DT Article DE Disease outbreaks; Disease transmission; Models; Statistical; Poliomyelitis; Poliovirus; Surveillance; Risk assessment; Vaccination ID AFFECTING DETECTION SENSITIVITY; DETECTING WILD POLIOVIRUS; ACUTE FLACCID PARALYSIS; THEORETICAL FRAMEWORK; GLOBAL ERADICATION; POLICY OPTIONS; POLIOMYELITIS; EPIDEMIOLOGY; CAMPAIGN; IMMUNITY AB Background: Most poliovirus infections occur with no symptoms and this leads to the possibility of silent circulation, which complicates the confirmation of global goals to permanently end poliovirus transmission. Previous simple models based on hypothetical populations assumed perfect detection of symptomatic cases and suggested the need to observe no paralytic cases from wild polioviruses (WPVs) for approximately 3-4 years to achieve 95% confidence about eradication, but the complexities in real populations and the imperfect nature of surveillance require consideration. Methods: We revisit the probability of undetected poliovirus circulation using a more comprehensive model that reflects the conditions in a number of places with different characteristics related to WPV transmission, and we model the actual environmental WPV detection that occurred in Israel in 2013. We consider the analogous potential for undetected transmission of circulating vaccine-derived polioviruses. The model explicitly accounts for the impact of different vaccination activities before and after the last detected case of paralytic polio, different levels of surveillance, variability in transmissibility and neurovirulence among serotypes, and the possibility of asymptomatic participation in transmission by previously-vaccinated or infected individuals. Results: We find that prolonged circulation in the absence of cases and thus undetectable by case-based surveillance may occur if vaccination keeps population immunity close to but not over the threshold required for the interruption of transmission, as may occur in northwestern Nigeria for serotype 2 circulating vaccine-derived poliovirus in the event of insufficient tOPV use. Participation of IPV-vaccinated individuals in asymptomatic fecal-oral transmission may also contribute to extended transmission undetectable by case-based surveillance, as occurred in Israel. We also find that gaps or quality issues in surveillance could significantly reduce confidence about actual disruption. Maintaining high population immunity and high-quality surveillance for several years after the last detected polio cases will remain critical elements of the polio end game. Conclusions: Countries will need to maintain vigilance in their surveillance for polioviruses and recognize that their risks of undetected circulation may differ as a function of their efforts to manage population immunity and to identify cases or circulating live polioviruses. C1 [Kalkowska, Dominika A.; Tebbens, Radboud J. Duintjer; Thompson, Kimberly M.] Kid Risk Inc, Orlando, FL 32832 USA. [Kalkowska, Dominika A.] Delft Univ Technol, Delft, Netherlands. [Pallansch, Mark A.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Atlanta, GA USA. [Cochi, Stephen L.; Wassilak, Steven G. F.] Ctr Dis Control & Prevent, Ctr Global Hlth, Global Immunizat Div, Atlanta, GA USA. [Thompson, Kimberly M.] Univ Cent Florida, Coll Med, Orlando, FL 32816 USA. RP Thompson, KM (reprint author), Kid Risk Inc, 10524 Moss Pk Rd,Site 204-364, Orlando, FL 32832 USA. EM kimt@kidrisk.org FU U.S. Centers for Disease Control and Prevention (CDC) [U66IP000519] FX Three authors (DAK, RJDT, KMT) acknowledge support from the U.S. Centers for Disease Control and Prevention (CDC) under Cooperative Agreement U66IP000519. The contents of this article are solely the responsibility of the authors and do not necessarily represent the official views of the CDC. NR 46 TC 11 Z9 11 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD FEB 18 PY 2015 VL 15 AR 66 DI 10.1186/s12879-015-0791-5 PG 12 WC Infectious Diseases SC Infectious Diseases GA CC0XX UT WOS:000350064500001 PM 25886823 ER PT J AU Voordouw, MJ Lachish, S Dolan, MC AF Voordouw, Maarten J. Lachish, Shelly Dolan, Marc C. TI The Lyme Disease Pathogen Has No Effect on the Survival of Its Rodent Reservoir Host SO PLOS ONE LA English DT Article ID WHITE-FOOTED MICE; IXODES-SCAPULARIS ACARI; BORRELIA-BURGDORFERI INFECTION; POLYMERASE-CHAIN-REACTION; SENSU-STRICTO STRAINS; EASTERN UNITED-STATES; WILD BIRD POPULATION; PEROMYSCUS-LEUCOPUS; ENDEMIC MALARIA; TAMIAS-STRIATUS AB Zoonotic pathogens that cause devastating morbidity and mortality in humans may be relatively harmless in their natural reservoir hosts. The tick-borne bacterium Borrelia burgdorferi causes Lyme disease in humans but few studies have investigated whether this pathogen reduces the fitness of its reservoir hosts under natural conditions. We analyzed four years of capture-mark-recapture (CMR) data on a population of white-footed mice, Peromyscus leucopus, to test whether B. burgdorferi and its tick vector affect the survival of this important reservoir host. We used a multi-state CMR approach to model mouse survival and mouse infection rates as a function of a variety of ecologically relevant explanatory factors. We found no effect of B. burgdorferi infection or tick burden on the survival of P. leucopus. Our estimates of the probability of infection varied by an order of magnitude (0.051 to 0.535) and were consistent with our understanding of Lyme disease in the Northeastern United States. B. burgdorferi establishes a chronic avirulent infection in their rodent reservoir hosts because this pathogen depends on rodent mobility to achieve transmission to its sedentary tick vector. The estimates of B. burgdorferi infection risk will facilitate future theoretical studies on the epidemiology of Lyme disease. C1 [Voordouw, Maarten J.] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA. [Lachish, Shelly] Univ Oxford, Dept Zool, Edward Grey Inst, Oxford, England. [Dolan, Marc C.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Natl Ctr Enter & Zoonot Infect Dis, Ft Collins, CO USA. RP Voordouw, MJ (reprint author), Univ Neuchatel, Inst Biol, CH-2000 Neuchatel, Switzerland. EM maarten.voordouw@unine.ch RI Dey, Kamalesh/E-6568-2017; OI Voordouw, Maarten/0000-0001-9384-0436 FU Centers for Diseases Control and Prevention [CK000170]; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIAID) [AI076342]; Swiss National Science Foundation [FN 31003A_141153] FX The study was supported by grant CK000170 from the Centers for Diseases Control and Prevention and AI076342 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIAID). This work was also supported by a grant from the Swiss National Science Foundation to Maarten Voordouw (FN 31003A_141153). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 86 TC 8 Z9 8 U1 6 U2 32 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 17 PY 2015 VL 10 IS 2 AR UNSP e0118265 DI 10.1371/journal.pone.0118265 PG 26 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CC4KQ UT WOS:000350322700110 PM 25688863 ER PT J AU Cortese, MM Dahl, RM Curns, AT Parashar, UD AF Cortese, Margaret M. Dahl, Rebecca Moritz Curns, Aaron T. Parashar, Umesh D. TI Protection Against Gastroenteritis in US Households With Children Who Received Rotavirus Vaccine SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE rotavirus vaccine; indirect protection; adults; household; rotavirus; diarrhea; gastroenteritis; immunization ID HEALTH-CARE UTILIZATION; UNITED-STATES; OLDER CHILDREN; ADULTS; HOSPITALIZATIONS; DIARRHEA; INFECTION; REDUCTION AB We used Truven Health Marketscan claims database (2008-2011) to compare gastroenteritis rates during January-June among households whose child had received rotavirus vaccine with those whose child did not receive vaccine. Statistically significantly lower rates of hospitalization with a rotavirus gastroenteritis or unspecified-gastroenteritis discharge code occurred in vaccinated households among persons 20-29 years and females 20-29 years (2008/2009), and males 30-39 years (2009/2010). Lower emergency department gastroenteritis rates occurred in vaccinated households among females 20-29 years (2009/2010) and individuals 5-19 years (2010/2011). These data suggest rotavirus vaccination of infants provides indirect protection against moderate-to-severe rotavirus disease in young parents and older siblings. C1 [Cortese, Margaret M.; Dahl, Rebecca Moritz; Curns, Aaron T.; Parashar, Umesh D.] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Cortese, MM (reprint author), 1600 Clifton Rd,MS A34, Atlanta, GA 30333 USA. EM mcortese@cdc.gov NR 13 TC 9 Z9 9 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD FEB 15 PY 2015 VL 211 IS 4 BP 558 EP 562 DI 10.1093/infdis/jiu503 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CC3CJ UT WOS:000350221800008 PM 25234721 ER PT J AU McElroy, AK Spiropoulou, CF AF McElroy, Anita K. Spiropoulou, Christina F. TI A Practical Treatment for Patients With Ebola Virus Disease Reply SO JOURNAL OF INFECTIOUS DISEASES LA English DT Letter C1 [McElroy, Anita K.] Emory Pediat Infect Dis, Atlanta, GA USA. [McElroy, Anita K.; Spiropoulou, Christina F.] US Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Atlanta, GA USA. RP McElroy, AK (reprint author), Emory Univ, Dept Pediat, Div Infect Dis, 2015 Uppergate Dr,Suite 500, Atlanta, GA 30322 USA. EM akmcelr@emory.edu FU Intramural CDC HHS [CC999999] NR 4 TC 1 Z9 1 U1 1 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD FEB 15 PY 2015 VL 211 IS 4 DI 10.1093/infdis/jiu475 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CC3CJ UT WOS:000350221800020 PM 25160982 ER PT J AU Han, XS Lin, CC Li, CY de Moor, JS Rodriguez, JL Kent, EE Forsythe, LP AF Han, Xuesong Lin, Chun Chieh Li, Chunyu de Moor, Janet S. Rodriguez, Juan L. Kent, Erin E. Forsythe, Laura P. TI Association Between Serious Psychological Distress and Health Care Use and Expenditures by Cancer History SO CANCER LA English DT Article; Proceedings Paper CT American-Society-of-Clinical-Oncology (ASCO) Quality Care Symposium CY OCT 17-18, 2014 CL Boston, MA SP Amer Soc Clin Oncol DE psychological distress; health care use; medical expenditures; psychosocial care ID LONG-TERM SURVIVORS; PSYCHOSOCIAL CARE; UNITED-STATES; POPULATION; DEPRESSION; SERVICES; ADULTS; INTERVENTIONS; ILLNESS; TRENDS AB BACKGROUNDSerious psychological distress (SPD) is associated with adverse health outcomes such as poor quality of life and shorter survival in cancer survivors, but to the authors' knowledge, the relationship between SPD and health care use and medical expenditures is not clear. METHODSA total of 4326 cancer survivors and 57,109 noncancer participants were identified from the 2008 through 2010 Medical Expenditure Panel Survey, a nationwide population-based survey, and their psychological distress was assessed with the 6-item Kessler Psychological Distress Scale (SPD defined by a score 13). The association between SPD and use and medical expenditures of various types of health care (office-based, outpatient, hospital inpatient, emergency department, dental, and prescriptions) was examined using a 2-part modeling approach that adjusted for demographic, personal, and comorbidity factors. The marginal effects of SPD on health care use and expenditures were calculated for cancer survivors and were compared with those of noncancer participants. RESULTSThe weighted prevalence of SPD in cancer survivors was 8.2% compared with 4.8% in the noncancer participants. SPD was significantly associated with higher use of all care types except dental care in cancer survivors. Cancer survivors with SPD spent $4431 (95% confidence interval, $3419-$5443) more than survivors without SPD on medical services each year, whereas this extra expenditure associated with SPD for participants without cancer was $2685 (95% confidence interval, $2099-$3271). CONCLUSIONSIn a national representative sample of cancer survivors, SPD was found to be associated with higher health care use and medical expenditures. Distress screening and psychosocial care in cancer survivors may help reduce the economic burden of cancer in the United States. Cancer 2015;121:614-622. (c) 2014 American Cancer Society. Serious psychological distress is reported to be associated with adverse health outcomes such as poor quality of life and shorter survival in cancer survivors. In a national representative sample of cancer survivors, serious psychological distress was found to be associated with higher health care use and medical expenditures. C1 [Han, Xuesong; Lin, Chun Chieh] Amer Canc Soc, Surveillance & Hlth Serv Res Program, Atlanta, GA 30303 USA. [Li, Chunyu; Rodriguez, Juan L.] Ctr Dis Control & Prevent, Epidemiol & Appl Res Branch, Div Canc Prevent & Control, Atlanta, GA USA. [de Moor, Janet S.] NCI, Hlth Serv & Econ Branch, NIH, Bethesda, MD 20892 USA. [Kent, Erin E.] NCI, Outcomes Res Branch, NIH, Bethesda, MD 20892 USA. [Forsythe, Laura P.] Patient Ctr Outcomes Res Inst, Res Integrat & Evaluat Program, Washington, DC USA. RP Han, XS (reprint author), Amer Canc Soc, Surveillance & Hlth Serv Res Program, 250 Williams St NW, Atlanta, GA 30303 USA. EM xuesong.han@cancer.org FU Intramural CDC HHS [CC999999] NR 34 TC 11 Z9 11 U1 2 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0008-543X EI 1097-0142 J9 CANCER-AM CANCER SOC JI Cancer PD FEB 15 PY 2015 VL 121 IS 4 BP 614 EP 622 DI 10.1002/cncr.29102 PG 9 WC Oncology SC Oncology GA CB1NS UT WOS:000349395200018 PM 25345778 ER PT J AU Liebman, KA Pinto, J Valle, J Palomino, M Vizcaino, L Brogdon, W Lenhart, A AF Liebman, Kelly A. Pinto, Jesus Valle, Jorge Palomino, Miriam Vizcaino, Lucrecia Brogdon, William Lenhart, Audrey TI Novel mutations on the ace-1 gene of the malaria vector Anopheles albimanus provide evidence for balancing selection in an area of high insecticide resistance in Peru SO MALARIA JOURNAL LA English DT Article DE Insecticide resistance; Malaria; Anopheles albimanus; Insensitive acetylcholinesterase; Ace-1; Gene duplication; Balancing selection ID MOSQUITO CULEX-PIPIENS; AMINO-ACID SUBSTITUTIONS; WESTERN BURKINA-FASO; INSENSITIVE ACETYLCHOLINESTERASE; GAMBIAE; POPULATIONS; CARBAMATE; CULICIDAE; DIPTERA; CONFER AB Background: Resistance to multiple classes of insecticides has been detected in the malaria vector Anopheles albimanus in northwest Peru. Acetylcholinesterase (AChE) insensitivity has previously been associated with resistance to organophosphate (OP) and carbamate (CA) insecticides in arthropods. A single point mutation on the ace-1 gene (G119S) associated with resistance to OPs and CAs has been described previously in four anopheline species, but not in field-collected An. albimanus. The present study aimed to characterize the role of ace-1 in conferring resistance to both OPs and CAs in the An. albimanus population in Tumbes, Peru. Methods: The frequency and intensity of resistance to OPs and CAs was quantified through bioassays of female An. albimanus collected between 2012 and 2014, and the presence of insensitive AChE was confirmed using biochemical assays. A portion of the ace-1 gene flanking codon 119 was amplified and sequenced from individuals used in the bioassays and biochemical assays, as well as from historical samples collected in 2008. Statistical analyses were conducted to determine: (1) associations between genotype and AChE insensitivity; and, (2) associations between genotype and resistance phenotype. Results: After confirming high levels of resistance to fenitrothion, malathion, and bendiocarb through bioassays, two novel polymorphisms were identified at the first and second loci of codon 119, with all individuals from the 2012-2014 collections being heterozygous at the first base (G/T) and either heterozygous (G/C) or homozygous mutants (C/C) at the second base. Based on sequence data from historical samples, these mutations arose prior to 2008, but became fixed in the population between 2008 and 2012. Homozygotes at the second locus had significantly higher levels of AChE insensitivity than heterozygotes (p < 0.05). Individuals phenotypically susceptible to OPs and CAs were more likely to be heterozygous at the second locus (p < 0.01). Cloning identified four individuals each containing three distinct genotypes, suggesting that a duplication of the ace-1 gene may have occurred. Conclusions: The occurrence of heterozygotes at two loci and the presence of three genotypes in four individuals suggest that balancing selection could be maintaining OP and CA resistance in this population, while minimizing associated fitness costs. C1 [Liebman, Kelly A.; Vizcaino, Lucrecia; Brogdon, William; Lenhart, Audrey] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Pinto, Jesus; Valle, Jorge; Palomino, Miriam] Inst Nacl Salud, Lima, Peru. [Liebman, Kelly A.] Amer Soc Microbiol, Washington, DC USA. RP Lenhart, A (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. EM Ajl8@cdc.gov FU Amazon Malaria Initiative (AMI/USAID); Centers for Disease Control and Prevention; American Society for Microbiology FX We thank our collaborators at the Instituto Nacional de Salud Peru in Lima and at the Laboratorio de Referencia Regional de la Direccion Regional de Salud in Tumbes, Percy Piruzaga, German Villanueva and Jose William Sandoval, as well as Gissella Vasquez at the Navy Medical Research Unit - 6 in Lima, Peru for providing historical samples. Funding was provided by the Amazon Malaria Initiative (AMI/USAID), Centers for Disease Control and Prevention and the American Society for Microbiology. NR 45 TC 2 Z9 3 U1 2 U2 11 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD FEB 14 PY 2015 VL 14 AR 74 DI 10.1186/s12936-015-0599-1 PG 10 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CB9BI UT WOS:000349925900002 PM 25889700 ER PT J AU Shah, M Omosun, Y Lal, A Odero, C Gatei, W Otieno, K Gimnig, JE ter Kuile, F Hawley, WA Nahlen, B Kariuki, S Walker, E Slutsker, L Hamel, M Shi, YP AF Shah, Monica Omosun, Yusuf Lal, Ashima Odero, Christopher Gatei, Wangeci Otieno, Kephas Gimnig, John E. ter Kuile, Feiko Hawley, William A. Nahlen, Bernard Kariuki, Simon Walker, Edward Slutsker, Laurence Hamel, Mary Shi, Ya Ping TI Assessment of molecular markers for anti-malarial drug resistance after the introduction and scale-up of malaria control interventions in western Kenya SO MALARIA JOURNAL LA English DT Article DE Anti-malarial drug resistance; ITNs; Chloroquine resistance; Sulphadoxine-pyrimethamine resistance; ACT resistance; Vector control ID PLASMODIUM-FALCIPARUM MALARIA; TREATED BED NETS; PFMDR1 COPY NUMBER; SULFADOXINE-PYRIMETHAMINE; DIHYDROFOLATE-REDUCTASE; CHLOROQUINE RESISTANCE; ARTEMISININ RESISTANCE; UNCOMPLICATED MALARIA; ARTESUNATE-MEFLOQUINE; POPULATION-STRUCTURE AB Background: Although it is well known that drug pressure selects for drug-resistant parasites, the role of transmission reduction by insecticide-treated bed nets (ITNs) on drug resistance remains unclear. In this study, the drug resistance profile of current and previous first-line anti-malarials in Kenya was assessed within the context of drug policy change and scale-up of ITNs. National first-line treatment changed from chloroquine (CQ) to sulphadoxine-pyrimethamine (SP) in 1998 and to artemether-lumefantrine (AL) in 2004. ITN use was scaled-up in the Asembo, Gem and Karemo areas of western Kenya in 1997, 1999 and 2006, respectively. Methods: Smear-positive samples (N = 253) collected from a 2007 cross-sectional survey among children in Asembo, Gem and Karemo were genotyped for mutations in pfcrt and pfmdr1 (CQ), dhfr and dhps (SP), and at pfmdr-N86 and the gene copy number in pfmdr1 (lumefantrine). Results were compared among the three geographic areas in 2007 and to retrospective molecular data from children in Asembo in 2001. Results: In 2007, 69 and 85% of samples harboured the pfmdr1-86Y mutation and dhfr/dhps quintuple mutant, respectively, with no significant differences by study area. However, the prevalence of the pfcrt-76T mutation differed significantly among areas (p < 0.02), between 76 and 94%, with the highest prevalence in Asembo. Several 2007 samples carried mutations at dhfr-164L, dhps-436A, or dhps-613T. From 2001 to 2007, there were significant increases in the pfcrt-76T mutation from 82 to 94% (p < 0.03), dhfr/dhps quintuple mutant from 62 to 82% (p < 0.03), and an increase in the septuple CQ and SP combined mutant haplotype, K(76)Y(86)I(51)R(59)N(108)G(437)E(540), from 28 to 39%. The prevalence of the pfmdr1-86Y mutation remained unchanged. All samples were single copy for pfmdr1. Conclusions: Molecular markers associated with lumefantrine resistance were not detected in 2007. More recent samples will be needed to detect any selective effects by AL. The prevalence of CQ and SP resistance markers increased from 2001 to 2007 in the absence of changes in transmission intensity. In 2007, only the prevalence of pfcrt-76T mutation differed among study areas of varying transmission intensity. Resistant parasites were most likely selected by sustained drug pressure from the continued use of CQ, SP, and mechanistically similar drugs, such as amodiaquine and cotrimoxazole. There was no clear evidence that differences in transmission intensity, as a result of ITN scale-up, influenced the prevalence of drug resistance molecular markers. C1 [Shah, Monica; Omosun, Yusuf; Lal, Ashima; Gatei, Wangeci; Gimnig, John E.; Hawley, William A.; Slutsker, Laurence; Hamel, Mary; Shi, Ya Ping] Ctr Dis Control & Prevent, Ctr Global Hlth, Malaria Branch, Atlanta, GA 30333 USA. [Shah, Monica; Omosun, Yusuf; Lal, Ashima; Gatei, Wangeci; Gimnig, John E.; Hawley, William A.; Slutsker, Laurence; Hamel, Mary; Shi, Ya Ping] Ctr Dis Control & Prevent, Ctr Global Hlth, Div Parasit Dis & Malaria, Atlanta, GA USA. [Shah, Monica; Omosun, Yusuf; Lal, Ashima] Atlanta Res & Educ Fdn, Atlanta, GA USA. [Odero, Christopher; Otieno, Kephas; Kariuki, Simon; Hamel, Mary] Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Kisumu, Kenya. [ter Kuile, Feiko] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England. [Hawley, William A.] UNICEF, Jakarta, Indonesia. [Nahlen, Bernard] Presidents Malaria Initiat, Washington, DC USA. [Walker, Edward] Michigan State Univ, E Lansing, MI 48824 USA. RP Shi, YP (reprint author), Ctr Dis Control & Prevent, Ctr Global Hlth, Malaria Branch, Atlanta, GA 30333 USA. EM yps0@cdc.gov OI Omosun, Yusuf/0000-0003-4759-6254; ter Kuile, Feiko/0000-0003-3663-5617 FU Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention; US National Science Foundation, Ecology of Infectious Diseases [EF-0723770] FX We express gratitude to all the study participants for their involvement in the current study. We would like to thank Kimberly Lindblade for providing data from the 2001 survey. Our appreciation extends to the KEMRI/CDC field workers and malaria laboratory staff in Kisumu who assisted with this study and phase II of ITN trial. We thank the Director, Kenya Medical Research Institute for permission to publish this paper. This study is financially supported by Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention and by US National Science Foundation, Ecology of Infectious Diseases grant # EF-0723770. NR 53 TC 5 Z9 5 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD FEB 14 PY 2015 VL 14 AR 75 DI 10.1186/s12936-015-0588-4 PG 14 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CB7HZ UT WOS:000349798900001 PM 25889220 ER PT J AU Fawley, WN Knetsch, CW MacCannell, DR Harmanus, C Du, T Mulvey, MR Paulick, A Anderson, L Kuijper, EJ Wilcox, MH AF Fawley, Warren N. Knetsch, C. W. MacCannell, Duncan R. Harmanus, Celine Du, Tim Mulvey, Michael R. Paulick, Ashley Anderson, Lydia Kuijper, E. J. Wilcox, Mark H. TI Development and Validation of an Internationally-Standardized, High-Resolution Capillary Gel-Based Electrophoresis PCR-Ribotyping Protocol for Clostridium difficile SO PLOS ONE LA English DT Article ID CHANGING EPIDEMIOLOGY; TYPING METHODS; INFECTION; STRAINS; SCHEME AB PCR-ribotyping has been adopted in many laboratories as the method of choice for C. difficile typing and surveillance. However, issues with the conventional agarose gel-based technique, including inter-laboratory variation and interpretation of banding patterns have impeded progress. The method has recently been adapted to incorporate high-resolution capillary gel-based electrophoresis (CE-ribotyping), so improving discrimination, accuracy and reproducibility. However, reports to date have all represented single-centre studies and inter-laboratory variability has not been formally measured or assessed. Here, we achieved in a multi-centre setting a high level of reproducibility, accuracy and portability associated with a consensus CE-ribotyping protocol. Local databases were built at four participating laboratories using a distributed set of 70 known PCR-ribotypes. A panel of 50 isolates and 60 electronic profiles (blinded and randomized) were distributed to each testing centre for PCR-ribotype identification based on local databases generated using the standard set of 70 PCR-ribotypes, and the performance of the consensus protocol assessed. A maximum standard deviation of only +/- 3.8bp was recorded in individual fragment sizes, and PCR-ribotypes from 98.2% of anonymised strains were successfully discriminated across four ribotyping centres spanning Europe and North America (98.8% after analysing discrepancies). Consensus CE-ribotyping increases comparability of typing data between centres and thereby facilitates the rapid and accurate transfer of standardized typing data to support future national and international C. difficile surveillance programs. C1 [Fawley, Warren N.; Wilcox, Mark H.] Leeds Teaching Hosp NHS Trust, Dept Microbiol, Leeds, W Yorkshire, England. [MacCannell, Duncan R.; Paulick, Ashley; Anderson, Lydia] Ctr Dis Control & Prevent CDC, Atlanta, GA USA. [Knetsch, C. W.; Harmanus, Celine; Kuijper, E. J.] Leiden Univ, Med Ctr, Ctr Infect Dis, Dept Med Microbiol, Leiden, Netherlands. [Du, Tim; Mulvey, Michael R.] PHAC, Winnipeg, MB, Canada. [Wilcox, Mark H.] Univ Leeds, Leeds Inst Mol Med, Leeds, W Yorkshire, England. RP Wilcox, MH (reprint author), Leeds Teaching Hosp NHS Trust, Dept Microbiol, Leeds, W Yorkshire, England. EM mark.wilcox@leedsth.nhs.uk NR 29 TC 21 Z9 22 U1 2 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 13 PY 2015 VL 10 IS 2 AR e0118150 DI 10.1371/journal.pone.0118150 PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CC9IO UT WOS:000350682600109 PM 25679978 ER PT J AU Khangura, SD Karaceper, MD Trakadis, Y Mitchell, JJ Chakraborty, P Tingley, K Coyle, D Grosse, SD Kronick, JB Laberge, AM Little, J Prasad, C Sikora, L Siriwardena, K Sparkes, R Speechley, KN Stockler, S Wilson, BJ Wilson, K Zayed, R Potter, BK AF Khangura, Sara D. Karaceper, Maria D. Trakadis, Yannis Mitchell, John J. Chakraborty, Pranesh Tingley, Kylie Coyle, Doug Grosse, Scott D. Kronick, Jonathan B. Laberge, Anne-Marie Little, Julian Prasad, Chitra Sikora, Lindsey Siriwardena, Komudi Sparkes, Rebecca Speechley, Kathy N. Stockler, Sylvia Wilson, Brenda J. Wilson, Kumanan Zayed, Reem Potter, Beth K. CA Canadian Inherited Metabolic Dis R TI Scoping review of patient- and family-oriented outcomes and measures for chronic pediatric disease SO BMC PEDIATRICS LA English DT Article DE Patient-centered outcomes research; Patient-centered care; Outcomes research; Outcome measures; Metabolism; Inborn errors; Assessment; Patient outcomes; Rare diseases; Family-centered care ID QUALITY-OF-LIFE; RARE DISEASES; CENTERED CARE; REPORTED OUTCOMES; HEALTH-CARE; MEDICINE; CHILDREN; PERSPECTIVES; TRANSITION; CHALLENGES AB Background: Improvements in health care for children with chronic diseases must be informed by research that emphasizes outcomes of importance to patients and families. To support a program of research in the field of rare inborn errors of metabolism (IEM), we conducted a broad scoping review of primary studies that: (i) focused on chronic pediatric diseases similar to IEM in etiology or manifestations and in complexity of management; (ii) reported patient- and/or family-oriented outcomes; and (iii) measured these outcomes using self-administered tools. Methods: We developed a comprehensive review protocol and implemented an electronic search strategy to identify relevant citations in Medline, EMBASE, DARE and Cochrane. Two reviewers applied pre-specified criteria to titles/abstracts using a liberal accelerated approach. Articles eligible for full-text review were screened by two independent reviewers with discrepancies resolved by consensus. One researcher abstracted data on study characteristics, patient-and family-oriented outcomes, and self-administered measures. Data were validated by a second researcher. Results: 4,118 citations were screened with 304 articles included. Across all included reports, the most-represented diseases were diabetes (35%), cerebral palsy (23%) and epilepsy (18%). We identified 43 unique patient- and family-oriented outcomes from among five emergent domains, with mental health outcomes appearing most frequently. The studies reported the use of 405 independent self-administered measures of these outcomes. Conclusions: Patient- and family-oriented research investigating chronic pediatric diseases emphasizes mental health and appears to be relatively well-developed in the diabetes literature. Future research can build on this foundation while identifying additional outcomes that are priorities for patients and families. C1 [Khangura, Sara D.; Karaceper, Maria D.; Chakraborty, Pranesh; Tingley, Kylie; Coyle, Doug; Grosse, Scott D.; Little, Julian; Sikora, Lindsey; Wilson, Brenda J.; Zayed, Reem; Potter, Beth K.] Univ Ottawa, Ottawa, ON, Canada. [Trakadis, Yannis; Mitchell, John J.] McGill Univ, Ctr Hlth, Montreal Childrens Hosp, Montreal, PQ, Canada. [Chakraborty, Pranesh] Childrens Hosp Eastern Ontario, Newborn Screening Ontario, Ottawa, ON K1H 8L1, Canada. [Grosse, Scott D.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Kronick, Jonathan B.] Univ Toronto, Toronto, ON, Canada. [Kronick, Jonathan B.; Siriwardena, Komudi] Hosp Sick Children, Toronto, ON M5G 1X8, Canada. [Laberge, Anne-Marie] Ctr Hosp Univ St Justine, Montreal, PQ, Canada. [Prasad, Chitra; Speechley, Kathy N.] Univ Western Ontario, London, ON, Canada. [Sparkes, Rebecca] Alberta Childrens Prov Gen Hosp, Calgary, AB, Canada. [Stockler, Sylvia] British Columbia Childrens Hosp, Vancouver, BC V6H 3V4, Canada. [Wilson, Kumanan] Ottawa Hosp Res Inst, Ottawa, ON, Canada. RP Potter, BK (reprint author), Univ Ottawa, 451 Smyth Rd, Ottawa, ON, Canada. EM beth.potter@uottawa.ca OI Sikora, Lindsey/0000-0002-9715-8634; Khangura, Sara/0000-0003-0094-6771 FU Canadian Institutes of Health Research (CIHR) [TR3-119195]; CIHR FX Thanks go to Ms. Joan Peterson for her assistance with data acquisition. All phases of this study were supported by a Canadian Institutes of Health Research (CIHR) grant, TR3-119195. The sponsor has had no role in the study design; the collection, analysis, and interpretation of data; the writing of the report; nor the decision to submit the paper for publication. Sara D. Khangura produced the first draft of the manuscript and is employed by the University of Ottawa under the auspices of this study's CIHR funding. NR 50 TC 2 Z9 2 U1 3 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2431 J9 BMC PEDIATR JI BMC Pediatr. PD FEB 13 PY 2015 VL 15 AR 7 DI 10.1186/s12887-015-0323-x PG 9 WC Pediatrics SC Pediatrics GA CB8FE UT WOS:000349863400001 PM 25886474 ER PT J AU Bang, KM Mazurek, JM Wood, JM White, GE Hendricks, SA Weston, A AF Bang, Ki Moon Mazurek, Jacek M. Wood, John M. White, Gretchen E. Hendricks, Scott A. Weston, Ainsley TI Silicosis Mortality Trends and New Exposures to Respirable Crystalline Silica - United States, 2001-2010 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID WORKERS C1 [Bang, Ki Moon; Mazurek, Jacek M.; Wood, John M.; White, Gretchen E.; Weston, Ainsley] NIOSH, Div Resp Dis Studies, CDC, Atlanta, GA 30329 USA. [Hendricks, Scott A.] NIOSH, Div Safety Res, CDC, Atlanta, GA USA. RP Mazurek, JM (reprint author), NIOSH, Div Resp Dis Studies, CDC, Atlanta, GA 30329 USA. EM jmazurek1@cdc.gov NR 10 TC 11 Z9 11 U1 0 U2 7 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 13 PY 2015 VL 64 IS 5 BP 117 EP 120 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CB7VQ UT WOS:000349837000001 PM 25674992 ER PT J AU Smith, CL Hughes, SM Karwowski, MP Chevalier, MS Hall, E Joyner, SN Ritch, J Smith, JC Weil, LM Chung, WM Schrag, S Santibanez, S AF Smith, Charnetta L. Hughes, Sonya M. Karwowski, Mateusz P. Chevalier, Michelle S. Hall, Emily Joyner, Sibeso N. Ritch, Julia Smith, Jessica C. Weil, Lauren M. Chung, Wendy M. Schrag, Stephanie Santibanez, Scott TI Addressing Needs of Contacts of Ebola Patients During an Investigation of an Ebola Cluster in the United States - Dallas, Texas, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Smith, Charnetta L.; Karwowski, Mateusz P.; Chevalier, Michelle S.] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Smith, Charnetta L.] CDC, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Smith, Charnetta L.; Karwowski, Mateusz P.; Chevalier, Michelle S.; Schrag, Stephanie; Santibanez, Scott] CDC, Dallas Ebola Invest Team, Atlanta, GA 30333 USA. [Hughes, Sonya M.; Hall, Emily; Joyner, Sibeso N.; Ritch, Julia; Smith, Jessica C.; Weil, Lauren M.; Chung, Wendy M.] Dallas Cty Hlth & Human Serv, Irving, TX USA. RP Smith, CL (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM csmith21@cdc.gov NR 4 TC 4 Z9 4 U1 0 U2 10 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 13 PY 2015 VL 64 IS 5 BP 121 EP 123 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CB7VQ UT WOS:000349837000002 PM 25674993 ER PT J AU Grigg, C Waziri, NE Olayinka, AT Vertefeuille, JF AF Grigg, Cheri Waziri, Ndadilnasiya E. Olayinka, Adebola T. Vertefeuille, John F. TI Use of Group Quarantine in Ebola Control - Nigeria, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID DISEASE OUTBREAK C1 [Grigg, Cheri] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Grigg, Cheri] CDC, Div Healthcare Qual Promot, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Waziri, Ndadilnasiya E.; Olayinka, Adebola T.] Nigeria Field Epidemiol & Lab Training Programme, Abuja, Nigeria. [Vertefeuille, John F.] CDC, Global Immunizat Div, Ctr Global Hlth, Atlanta, GA 30333 USA. RP Grigg, C (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM cgrigg@cdc.gov NR 2 TC 3 Z9 3 U1 1 U2 7 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 13 PY 2015 VL 64 IS 5 BP 124 EP 124 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CB7VQ UT WOS:000349837000003 PM 25674994 ER PT J AU Friedman, GK Harrison, R Bojes, H Worthington, K Filios, M AF Friedman, Gary K. Harrison, Robert Bojes, Heidi Worthington, Karen Filios, Margaret TI Silicosis in a Countertop Fabricator - Texas, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID QUARTZ CONGLOMERATE WORKERS C1 [Friedman, Gary K.] Univ Texas Hlth Houston, Pulm Div, Houston, TX USA. [Bojes, Heidi] Texas Dept State Hlth Serv, Houston, TX USA. [Worthington, Karen] New Jersey Dept Hlth & Senior Serv, Trenton, NJ USA. [Filios, Margaret] NIOSH, Div Resp Dis Studies, CDC, Washington, DC 20201 USA. RP Filios, M (reprint author), NIOSH, Div Resp Dis Studies, CDC, Washington, DC 20201 USA. EM mfilios@cdc.gov NR 4 TC 5 Z9 5 U1 3 U2 6 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 13 PY 2015 VL 64 IS 5 BP 129 EP 130 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CB7VQ UT WOS:000349837000005 PM 25674996 ER PT J AU Nett, RJ Witte, TK Holzbauer, SM Elchos, BL Campagnolo, ER Musgrave, KJ Carter, KK Kurkjian, KM Vanicek, C O'Leary, DR Pride, KR Funk, RH AF Nett, Randall J. Witte, Tracy K. Holzbauer, Stacy M. Elchos, Brigid L. Campagnolo, Enzo R. Musgrave, Karl J. Carter, Kris K. Kurkjian, Katie M. Vanicek, Cole O'Leary, Daniel R. Pride, Kerry R. Funk, Renee H. TI Prevalence of Risk Factors for Suicide Among Veterinarians - United States, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Nett, Randall J.; Holzbauer, Stacy M.; Campagnolo, Enzo R.; Carter, Kris K.; Kurkjian, Katie M.; O'Leary, Daniel R.] CDC, Div State & Local Readiness, Off Publ Hlth Preparedness & Response, Atlanta, GA 30333 USA. [Witte, Tracy K.] Auburn Univ, Dept Psychol, Auburn, AL 36849 USA. [Holzbauer, Stacy M.] Minnesota Dept Hlth, Minneapolis, MN 55414 USA. [Elchos, Brigid L.] Mississippi Board Anim Hlth, Mississippi State, MS USA. [Elchos, Brigid L.] Wyoming Dept Hlth, Laramie, WY USA. [Musgrave, Karl J.; O'Leary, Daniel R.] Penn Dept Hlth, Harrisburg, PA 17108 USA. [Carter, Kris K.] Idaho Dept Hlth & Welfare, Pocatello, ID USA. [Kurkjian, Katie M.] Virginia Dept Hlth, Charlottesville, VA USA. [Funk, Renee H.] NIOSH, Emergency Preparedness & Response Off, CDC, Washington, DC USA. RP Nett, RJ (reprint author), CDC, Div State & Local Readiness, Off Publ Hlth Preparedness & Response, Atlanta, GA 30333 USA. EM rnett@cdc.gov NR 7 TC 2 Z9 2 U1 1 U2 10 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 13 PY 2015 VL 64 IS 5 BP 131 EP 132 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CB7VQ UT WOS:000349837000006 PM 25674997 ER PT J AU Liang, ZM Ke, BX Deng, XL Liang, JH Ran, L Lu, LL He, DM Huang, Q Ke, CW Li, ZJ Yu, HJ Klena, JD Wu, SY AF Liang, Zhaoming Ke, Bixia Deng, Xiaoling Liang, Junhua Ran, Lu Lu, Lingling He, Dongmei Huang, Qiong Ke, Changwen Li, Zhongjie Yu, Hongjie Klena, John D. Wu, Shuyu TI Serotypes, seasonal trends, and antibiotic resistance of non-typhoidal Salmonella from human patients in Guangdong Province, China, 2009-2012 SO BMC INFECTIOUS DISEASES LA English DT Article ID LABORATORY-BASED SURVEILLANCE; UNITED-STATES; DECREASED SUSCEPTIBILITY; ANTIMICROBIAL RESISTANCE; CHANGING EPIDEMIOLOGY; ENTERICA TYPHIMURIUM; INFECTIONS; FLUOROQUINOLONES; GYRA; PREVENTION AB Background: Non-typhoidal Salmonella is a common cause of infectious diarrhea in humans. Antimicrobial-resistant Salmonella has become a global concern. Methods: Using laboratory-based surveillance system for Salmonella from September 2009 to December 2012 in Guangdong Province of China. The clinical information and samples of diarrhea patients were collected, according to the surveillance case definition. The lab tests were followed by standardized protocols, including sample isolation, isolates confirmation, serotyping, and antimicrobial susceptibility testing (AST). Results: A total of 1,826 Salmonella isolates were identified from 40,572 patients in 28 hospitals in 11 prefectures. The isolates ratio was highest in autumn (38.8%, 708/1826) and lowest in winter (6.4%, 117/1826). Children aged < 5 years were the group most affected by Salmonella in Guangdong Province accounting for 73% (1,329/1,826), of whom the infants (< 1 year) were 81.5% (1084/1329) especially. A total of 108 serotypes were identified among the isolates. S. Typhimurium represented the most common serotype followed by serotype 4,5,12:i:-. S. Typhimurium was also the common serotype followed by S. Enteritidis among infants and children aged 1-3 years old. However, S. Enteritidis became the common serotype followed by S. Typhimurium among children aged 3-5 and >5 years. Resistance to at least one antimicrobial was found in 72% (1321/1,826) of the isolates. Resistance to at least three antimicrobials was found in 46% (850/1,826) of the isolates. Resistance to all 12 antimicrobials screened was observed in 8 isolates (0.44%, 8/1,826). The resistant prevalence to quinolones including nalidixic acid and ciprofloxacin was 61.9% (1131/1826), of which ciprofloxacin resistance rate was 8.05% (147/1826). The prevalence resistance to all three cephalosporin antimicrobials (cefepime, cefotaxime, and caftazidime) in < 5 yr age group was accounted for 90% (89/99). Conclusions: Additional data and more refined methods can improve future surveillance. The invasive Salmonella isolates should also be included to the antibiotic resistance surveillance for clinical care or public health. C1 [Liang, Zhaoming] Guangdong Prov Inst Biol Prod & Mat Med, Guangzhou, Guangdong, Peoples R China. [Liang, Zhaoming; Ke, Bixia; Deng, Xiaoling; Liang, Junhua; Lu, Lingling; He, Dongmei; Huang, Qiong; Ke, Changwen] Guangdong Prov Ctr Dis Control & Prevent, Guangzhou, Guangdong, Peoples R China. [Ran, Lu; Li, Zhongjie] Chinese Ctr Dis Control & Prevent, Off Dis Control & Emergency Response, Beijing, Peoples R China. [Klena, John D.; Wu, Shuyu] US Ctr Dis Control & Prevent, China US Collaborat Program Emerging & Reemerging, Beijing, Peoples R China. [Klena, John D.] US Ctr Dis Control & Prevent, Ctr Global Hlth, Div Global Hlth Protect, Global Dis Detect Branch, Atlanta, GA USA. RP Deng, XL (reprint author), Guangdong Prov Ctr Dis Control & Prevent, Guangzhou, Guangdong, Peoples R China. EM Dengxiaolinggd@aliyun.com FU China-U.S. Collaborative program on Emerging and Re-Emerging Infectious Diseases; National Major Projects of Major Infectious Disease Control and Prevention, the Ministry of Science and Technology of the People's Republic of China [2012ZX10004213-004] FX This study was supported by the China-U.S. Collaborative program on Emerging and Re-Emerging Infectious Diseases and the National Major Projects of Major Infectious Disease Control and Prevention, the Ministry of Science and Technology of the People's Republic of China (grant number:2012ZX10004213-004). NR 35 TC 12 Z9 14 U1 2 U2 14 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD FEB 12 PY 2015 VL 15 AR 53 DI 10.1186/s12879-015-0784-4 PG 9 WC Infectious Diseases SC Infectious Diseases GA CC0XS UT WOS:000350064000001 PM 25881319 ER PT J AU Otranto, D Giannelli, A Trumble, NS Chavkin, M Kennard, G Latrofa, MS Bowman, DD Dantas-Torres, F Eberhard, ML AF Otranto, Domenico Giannelli, Alessio Trumble, Nicole Scotty Chavkin, Matt Kennard, Gavin Latrofa, Maria Stefania Bowman, Dwight D. Dantas-Torres, Filipe Eberhard, Mark L. TI Clinical case presentation and a review of the literature of canine onchocercosis by Onchocerca lupi in the United States SO PARASITES & VECTORS LA English DT Review DE Onchocerca lupi; Canine onchocercosis; Zoonosis; United States; Clinical presentation ID DIROFILARIA-IMMITIS; WOLBACHIA ENDOSYMBIONT; HEARTWORM DISEASE; 2 DOGS; INFECTION; FILARIASIS; DOXYCYCLINE; IVERMECTIN; GREECE; COMBINATION AB Background: Onchocerca lupi, a filarioid of zoonotic concern, infects dogs and cats causing ocular lesions of different degrees, from minor to severe. However, infected animals do not always display overt clinical signs, rendering the diagnosis of the infection obscure to the majority of veterinarians. Canine onchocercosis has been reported in the Old World and the information on its occurrence in the United States, as well as its pathogenesis and clinical management is still meagre. This study reports on the largest case series of O. lupi infection from the United States and reviews previous cases of canine onchocercosis in this country. Methods: Information on the clinical history of a series of eight cases of O. lupi infection in dogs diagnosed in Minnesota, New Mexico, Colorado and Florida, from 2011 to 2014, was obtained from clinical records provided the veterinary practitioners. Nematodes were morphologically identified at species level and genetically analyzed. Results: All dogs displayed a similar clinical presentation, including subconjunctival and episcleral nodules, which were surgically removed. Each dog was subjected to post-operative therapy. Whitish filaria-like parasites were morphologically and molecularly identified as O. lupi. Conclusions: This study confirms that O. lupi is endemic in the United States, indicating that the distribution of the infection is probably wider than previously thought. With effect, further studies are urgently needed in order to improve the diagnosis and to assess the efficacy of therapeutic protocols, targeting the parasite itself and/or its endosymbionts. C1 [Otranto, Domenico; Giannelli, Alessio; Latrofa, Maria Stefania; Dantas-Torres, Filipe] Univ Bari, Dipartimento Med Vet, Bari, Italy. [Trumble, Nicole Scotty] BluePearl Vet Partners, Eden Prairie, MN USA. [Chavkin, Matt] VRCC Anim Eye Specialists, Englewood, CO USA. [Kennard, Gavin] Albuquerque Practice, Albuquerque, NM USA. [Bowman, Dwight D.] Cornell Univ, Ithaca, NY USA. [Dantas-Torres, Filipe] Ctr Pesquisas Aggeu Magalhaes Fiocruz PE, Dept Imunol, Recife, PE, Brazil. [Eberhard, Mark L.] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA USA. RP Otranto, D (reprint author), Univ Bari, Dipartimento Med Vet, Bari, Italy. EM domenico.otranto@uniba.it RI Dantas-Torres, Filipe/G-1617-2012; OI Latrofa, Maria Stefania/0000-0001-9061-437X; Otranto, Domenico/0000-0002-7518-476X; Giannelli, Alessio/0000-0001-5855-2906 FU Merial, France FX The authors wish to thank Merial, France for supporting the publication costs of this article. NR 34 TC 7 Z9 7 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1756-3305 J9 PARASITE VECTOR JI Parasites Vectors PD FEB 8 PY 2015 VL 8 AR 89 DI 10.1186/s13071-015-0699-3 PG 8 WC Parasitology SC Parasitology GA DD3RQ UT WOS:000369840700002 PM 25884672 ER PT J AU Mace, KE Chalwe, V Katalenich, BL Nambozi, M Mubikayi, L Mulele, CK Wiegand, RE Filler, SJ Kamuliwo, M Craig, AS Tan, KR AF Mace, Kimberly E. Chalwe, Victor Katalenich, Bonnie L. Nambozi, Michael Mubikayi, Luamba Mulele, Chikuli K. Wiegand, Ryan E. Filler, Scott J. Kamuliwo, Mulakwa Craig, Allen S. Tan, Kathrine R. TI Evaluation of sulphadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy: a retrospective birth outcomes study in Mansa, Zambia SO MALARIA JOURNAL LA English DT Article DE Plasmodium falciparum malaria; Intermittent preventive treatment of malaria in pregnancy; Sulphadoxine-pyrimethamine; Zambia ID PLASMODIUM-FALCIPARUM MALARIA; MOLECULAR MARKERS; CONTROLLED-TRIAL; PARASITE CLEARANCE; DRUG-RESISTANCE; WESTERN KENYA; BURKINA-FASO; WOMEN; MALAWI; PREVALENCE AB Background: Intermittent preventive treatment of malaria in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP) decreases placental parasitaemia, thus improving birth outcomes. Zambian policy recommends monthly SP-IPTp doses given presumptively during pregnancy at each antenatal examination, spaced one month apart after 16 weeks of gestation. The effectiveness of SP-IPTp was evaluated in Zambia where a recent study showed moderate prevalence of Plasmodium falciparum parasites with genetic mutations that confer SP resistance. Methods: HIV-negative women were enrolled at the time of delivery at two facilities in Mansa, Zambia, an area of high malaria transmission. Women were interviewed and SP exposure was determined by antenatal card documentation or self-reports. Using Poisson regression modelling, the effectiveness of SP-IPTp was evaluated for outcomes of parasitaemia (microscopic examination of maternal peripheral, cord, and placental blood films), maternal anaemia (Hb < 11 g/dl), placental infection (histopathology), and infant outcomes (low birth weight (LBW), preterm delivery, and small for gestational age) in women who took 0-4 doses of SP-IPTp. Results: Participants included 435 women, with a median age of 23 years (range 16-44). Thirty-four women took zero doses of SP-IPTp, while 115, 142 and 144 women took one, two, or >= three doses, respectively. Multivariate Poisson regression models considering age, mosquito net usage, indoor residual spraying, urban home, gravidity, facility, wet season delivery, and marital status showed that among paucigravid women >= two doses of SP-ITPp compared to one or less doses was associated with a protective effect on LBW (prevalence ratio (PR) 0.33, 95% confidence interval (CI) 0.12-0.91) and any infection (PR 0.76, CI 0.58-0.99). Multivariate models considering SP-IPTp as a continuous variable showed a protective dose-response association with LBW (paucigravid women: PR 0.54, CI 0.33-0.90, multigravid women: PR 0.63, CI 0.41-0.97). Conclusions: In Mansa, Zambia, an area of moderate SP resistance, >= two doses of SP-IPTp were associated with a protective effect from malaria in pregnancy, especially among paucigravid women. Each dose of SP-IPTp contributed to a 46 and 37% decrease in the frequency of LBW among paucigravid and multigravid women, respectively. SP-IPTp remains a viable strategy in this context. C1 [Mace, Kimberly E.; Wiegand, Ryan E.; Filler, Scott J.; Craig, Allen S.; Tan, Kathrine R.] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30333 USA. [Chalwe, Victor] Univ Zambia, Sch Med, Dept Publ Hlth, Lusaka, Zambia. [Katalenich, Bonnie L.] US Peace Corps, Lusaka, Zambia. [Nambozi, Michael] Trop Dis Res Ctr, Ndola, Zambia. [Mubikayi, Luamba] Ndola Cent Hosp, Ndola, Zambia. [Mulele, Chikuli K.] Wusakile Mine Hosp, Kitwe, Zambia. [Kamuliwo, Mulakwa] Natl Malaria Control Ctr, Lusaka, Zambia. RP Mace, KE (reprint author), Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, 4770 Buford Highway,Mail Stop F-12, Atlanta, GA 30333 USA. EM kmace@cdc.gov FU President's Malaria Initiative, US Agency for International Development; Centers for Disease Control and Prevention FX We gratefully acknowledge the participation of the patients, midwives, hospital administrators in this study. Julie Gutman, Feiko ter Kuile and the MiP Consortium provided technical guidance which improved the study implementation and analysis. This report was made possible through support provided by the President's Malaria Initiative, US Agency for International Development, under the terms of an Interagency Agreement with the Centers for Disease Control and Prevention. The findings, results and opinions expressed herein are those of the authors and do not necessarily reflect the views of the US Agency for International Development or the Centers for Disease Control and Prevention. NR 46 TC 3 Z9 4 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD FEB 7 PY 2015 VL 14 AR 69 DI 10.1186/s12936-015-0576-8 PG 11 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CC8FT UT WOS:000350604200001 PM 25890159 ER PT J AU Anderson, DC Lapp, SA Akinyi, S Meyer, EVS Barnwell, JW Korir-Morrison, C Galinski, MR AF Anderson, D. C. Lapp, Stacey A. Akinyi, Sheila Meyer, Esmeralda V. S. Barnwell, John W. Korir-Morrison, Cindy Galinski, Mary R. TI Plasmodium vivax trophozoite-stage proteomes SO JOURNAL OF PROTEOMICS LA English DT Article DE Plasmodium vivax; Proteomics; Malaria; Trophozoite stage; Infected red blood cell; Protein oxidation/nitration ID CAVEOLA-VESICLE COMPLEXES; FALCIPARUM-INFECTED ERYTHROCYTES; TANDEM MASS-SPECTROMETRY; HUMAN MALARIA PARASITE; PROTEIN OXIDATION; LIFE-CYCLE; PEPTIDE IDENTIFICATION; IMMUNE-RESPONSE; SCHUFFNERS DOTS; ANGIOTENSIN-II AB Plasmodium vivax is the causative infectious agent of 80-300 million annual cases of malaria. Many aspects of this parasite's biology remain unknown. To further elucidate the interaction of P. vivax with its Saimiri boliviensis host, we obtained detailed proteomes of infected red blood cells, representing the trophozoite-enriched stage of development. Data from two of three biological replicate proteomes, emphasized here, were analyzed using five search engines, which enhanced identifications and resulted in the most comprehensive P. vivax proteomes to date, with 1375 P. vivax and 3209 S. boliviensis identified proteins. Ribosome subunit proteins were noted for both P. vivax and S. boliviensis, consistent with P. vivax's known reticulocyte host cell specificity. A majority of the host and pathogen proteins identified belong to specific functional categories, and several parasite gene families, while 33% of the P. vivax proteins have no reported function. Hemoglobin was significantly oxidized in both proteomes, and additional protein oxidation and nitration was detected in one of the two proteomes. Detailed analyses of these post-translational modifications are presented. The proteins identified here significantly expand the known P. vivax proteome and complexity of available host protein functionality underlying the host parasite interactive biology, and reveal unsuspected oxidative modifications that may impact protein function. Biological significance Plasmodium vivax malaria is a serious neglected disease, causing an estimated 80 to 300 million cases annually in 95 countries. Infection can result in significant morbidity and possible death. P. vivax, unlike the much better-studied Plasmodium falciparum species, cannot be grown in long-term culture, has a dormant form in the liver called the hypnozoite stage, has a reticulocyte host cell preference in the blood, and creates caveolae vesicle complexes at the surface of the infected reticulocyte membranes. Studies of stage-specific P. vivax expressed proteomes have been limited in scope and focused mainly on pathogen proteins, thus limiting understanding of the biology of this pathogen and its host interactions. Here three P. vivax proteomes are reported from biological replicates based on purified trophozoite-infected reticulocytes from different Saimiri boliviensis infections (the main non-human primate experimental model for P. vivax biology and pathogenesis). An in-depth analysis of two of the proteomes using 2D LC/MS/MS and multiple search engines identified 1375 pathogen proteins and 3209 host proteins. Numerous functional categories of both host and pathogen proteins were identified, including several known P. vivax protein family members (e.g., PHIST, eTRAMP and VIR), and 33% of protein identifications were classified as hypothetical. Ribosome subunit proteins were noted for both P. vivax and S. boliviensis, consistent with this parasite species' known reticulocyte host-cell specificity. In two biological replicates analyzed for post-translational modifications, hemoglobin was extensively oxidized, and various other proteins were also oxidized or nitrated in one of the two replicates. The cause of such protein modification remains to be determined but could include oxidized heme and oxygen radicals released from the infected red blood cell's parasite-induced acidic digestive vacuoles. In any case, the data suggests the presence of distinct infection-specific conditions whereby both the pathogen and host infected red blood cell proteins may be subject to significant oxidative stress. (C) 2014 Published by Elsevier B.V. C1 [Anderson, D. C.] SRI Int, Ctr Canc & Metab, Harrisonburg, VA 22802 USA. [Lapp, Stacey A.; Akinyi, Sheila; Meyer, Esmeralda V. S.; Korir-Morrison, Cindy; Galinski, Mary R.] Emory Univ, Yerkes Natl Primate Res Ctr, Emory Vaccine Ctr, Atlanta, GA 30329 USA. [Barnwell, John W.] Ctr Dis Control & Prevent, Div Parasit Dis, Malaria Branch, Atlanta, GA 30333 USA. [Galinski, Mary R.] Emory Univ, Sch Med, Div Infect Dis, Dept Med, Atlanta, GA 30322 USA. RP Anderson, DC (reprint author), SRI Int, 140 Res Dr, Harrisonburg, VA 22802 USA. EM dave.anderson@sri.com FU SRI International; Federal funds from the US National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [R01-AI24710, HHSN272201200031C]; National Center for Research Resources [P51RR000165] FX We thank Dr. Walter Moos and SRI International for support of this work, and Prof. Mike Freitas and Owen Branson at Ohio State University for running the Mass Matrix analysis of Proteome 2. We thank Drs. Bing Lu and Lili Zhang of the Chinese Center for Disease Control (Beijing, China) for the preparation of the M. smegrnatis proteome. This project was funded in part by Federal funds from the US National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services under grant # R01-AI24710 and contract # HHSN272201200031C, and supported in part by the Office of Research Infrastructure Programs/OD P510D011132 (formerly National Center for Research Resources P51RR000165). NR 102 TC 8 Z9 8 U1 1 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1874-3919 EI 1876-7737 J9 J PROTEOMICS JI J. Proteomics PD FEB 6 PY 2015 VL 115 BP 157 EP 176 DI 10.1016/j.jprot.2014.12.010 PG 20 WC Biochemical Research Methods SC Biochemistry & Molecular Biology GA CC2OJ UT WOS:000350184200014 PM 25545414 ER PT J AU Kull, S Schulz, KM Strotmeier, JWN Kirchner, S Schreiber, T Bollenbach, A Dabrowski, PW Nitsche, A Kalb, SR Dorner, MB Barr, JR Rummel, A Dorner, BG AF Kull, Skadi Schulz, K. Melanie Strotmeier, Jasmin Weisemann Nee Kirchner, Sebastian Schreiber, Tanja Bollenbach, Alexander Dabrowski, P. Wojtek Nitsche, Andreas Kalb, Suzanne R. Dorner, Martin B. Barr, John R. Rummel, Andreas Dorner, Brigitte G. TI Isolation and Functional Characterization of the Novel Clostridium botulinum Neurotoxin A8 Subtype SO PLOS ONE LA English DT Article ID ANTIBODY-BASED IMMUNOASSAY; CURED MEAT SYSTEM; NEUROTRANSMITTER RELEASE; INFANT BOTULISM; SEROTYPE-A; E STRAINS; NUCLEOTIDE-SEQUENCE; ENZYMATIC-ACTIVITY; MASS-SPECTROMETRY; GENETIC DIVERSITY AB Botulism is a severe neurological disease caused by the complex family of botulinum neuro-toxins (BoNT). Based on the different serotypes known today, a classification of serotype variants termed subtypes has been proposed according to sequence diversity and immunological properties. However, the relevance of BoNT subtypes is currently not well understood. Here we describe the isolation of a novel Clostridium botulinum strain from a foodborne botulism outbreak near Chemnitz, Germany. Comparison of its botulinum neurotoxin gene sequence with published sequences identified it to be a novel subtype within the BoNT/A serotype designated BoNT/A8. The neurotoxin gene is located within an ha-orfX+ cluster and showed highest homology to BoNT/A1, A2, A5, and A6. Unexpectedly, we found an arginine insertion located in the HC domain of the heavy chain, which is unique compared to all other BoNT/A subtypes known so far. Functional characterization revealed that the binding characteristics to its main neuronal protein receptor SV2C seemed unaffected, whereas binding to membrane-incorporated gangliosides was reduced in comparison to BoNT/A1. Moreover, we found significantly lower enzymatic activity of the natural, full-length neurotoxin and the recombinant light chain of BoNT/A8 compared to BoNT/A1 in different endopeptidase assays. Both reduced ganglioside binding and enzymatic activity may contribute to the considerably lower biological activity of BoNT/A8 as measured in a mouse phrenic nerve hemidiaphragm assay. Despite its reduced activity the novel BoNT/A8 subtype caused severe botulism in a 63-year-old male. To our knowledge, this is the first description and a comprehensive characterization of a novel BoNT/A subtype which combines genetic information on the neurotoxin gene cluster with an in-depth functional analysis using different technical approaches. Our results show that subtyping of BoNT is highly relevant and that understanding of the detailed toxin function might pave the way for the development of novel therapeutics and tailor-made antitoxins. C1 [Kull, Skadi; Schulz, K. Melanie; Kirchner, Sebastian; Schreiber, Tanja; Dorner, Martin B.; Dorner, Brigitte G.] Robert Koch Inst, Ctr Biol Threats & Special Pathogens, Biol Toxins ZBS3, Berlin, Germany. [Strotmeier, Jasmin Weisemann Nee; Bollenbach, Alexander; Rummel, Andreas] Hannover Med Sch, Inst Toxikol, D-30623 Hannover, Germany. [Dabrowski, P. Wojtek; Nitsche, Andreas] Robert Koch Inst, Ctr Biol Threats & Special Pathogens, Highly Pathogen Viruses ZBS1, Berlin, Germany. [Kalb, Suzanne R.; Barr, John R.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA USA. RP Dorner, BG (reprint author), Robert Koch Inst, Ctr Biol Threats & Special Pathogens, Biol Toxins ZBS3, Berlin, Germany. EM DornerB@rki.de RI Dabrowski, Piotr/L-1423-2015; OI Dabrowski, Piotr/0000-0003-4893-805X; Kalb, Suzanne/0000-0002-8067-136X FU German Federal Ministry of Education and Research (BiGRUDI project) [13N9601]; Swiss Federal Department of Defence, Civil Protection and Sport, Spiez Laboratory [353003364/Stm]; Robert Koch-Institut [1362/I-979] FX This work was supported by grants from the German Federal Ministry of Education and Research (BiGRUDI project, 13N9601; http://www.bmbf.de) and by the Swiss Federal Department of Defence, Civil Protection and Sport, Spiez Laboratory (353003364/Stm; http://www.labor-spiez.ch) to BGD. AR was supported by the Robert Koch-Institut (1362/I-979; http://www.rki.de). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. NR 97 TC 20 Z9 20 U1 4 U2 16 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 6 PY 2015 VL 10 IS 2 AR e0116381 DI 10.1371/journal.pone.0116381 PG 25 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CB2GK UT WOS:000349444900037 PM 25658638 ER PT J AU Seth, P Walker, T Hollis, N Figueroa, A Belcher, L AF Seth, Puja Walker, Tanja Hollis, NaTasha Figueroa, Argelia Belcher, Lisa TI HIV Testing and Service Delivery Among Blacks or African Americans-61 Health Department Jurisdictions, United States, 2013 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID ANTIRETROVIRAL THERAPY C1 [Seth, Puja; Walker, Tanja; Hollis, NaTasha; Figueroa, Argelia; Belcher, Lisa] CDC, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. RP Seth, P (reprint author), CDC, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. EM pseth@cdc.gov FU health department in District of Columbia; health department in Puerto Rico; health department in U.S. Virgin Islands; health department Baltimore, Maryland; health department Chicago, Illinois; health department Fulton County, Georgia; health department Houston, Texas; health department Los Angeles County, California; health department New York, New York; health department Philadelphia, Pennsylvania; health department San Francisco, California FX Grantees include health departments in the 50 states, the District of Columbia, Puerto Rico, the U.S. Virgin Islands, and eight directly funded city/county health departments (Baltimore, Maryland; Chicago, Illinois; Fulton County, Georgia; Houston, Texas; Los Angeles County, California; New York, New York; Philadelphia, Pennsylvania; and San Francisco, California). NR 10 TC 3 Z9 3 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 6 PY 2015 VL 64 IS 4 BP 87 EP 90 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CA6JP UT WOS:000349019200002 PM 25654608 ER PT J AU Kim, DK Bridges, CB Harriman, KH AF Kim, David K. Bridges, Carolyn B. Harriman, Kathleen H. CA ACIP ACIP Adult Immunization Work Grp TI Advisory Committee on Immunization Practices Recommended Immunization Schedule for Adults Aged 19 Years or Older - United States, 2015 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID PRACTICES ACIP C1 [Kim, David K.; Bridges, Carolyn B.] CDC, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Harriman, Kathleen H.] Calif Dept Publ Hlth, Berkeley, CA USA. RP Kim, DK (reprint author), CDC, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM dkim@cdc.gov OI Epling, John W/0000-0001-9445-8669 NR 4 TC 30 Z9 30 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 6 PY 2015 VL 64 IS 4 BP 91 EP 92 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CA6JP UT WOS:000349019200003 PM 25654609 ER PT J AU Strikas, RA AF Strikas, Raymond A. CA ACIP ACIP Child Adolescent Immunization TI Advisory Committee on Immunization Practices Recommended Immunization Schedules for Persons Aged 0 Through 18 Years - United States, 2015 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Strikas, Raymond A.] CDC, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Strikas, RA (reprint author), CDC, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM ras8@cdc.gov NR 0 TC 30 Z9 31 U1 0 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 6 PY 2015 VL 64 IS 4 BP 93 EP 94 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CA6JP UT WOS:000349019200004 PM 25654610 ER PT J AU Williams, WW Lu, PJ O'Halloran, A Bridges, CB Kim, DK Pilishvili, T Hales, CM Markowitz, LE AF Williams, Walter W. Lu, Peng-Jun O'Halloran, Alissa Bridges, Carolyn B. Kim, David K. Pilishvili, Tamara Hales, Craig M. Markowitz, Lauri E. TI Vaccination Coverage Among Adults, Excluding Influenza Vaccination - United States, 2013 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Williams, Walter W.; Lu, Peng-Jun; O'Halloran, Alissa; Bridges, Carolyn B.; Kim, David K.] CDC, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Pilishvili, Tamara] CDC, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Hales, Craig M.] CDC, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Markowitz, Lauri E.] CDC, Div Sexually Transmitted Dis Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. RP Williams, WW (reprint author), CDC, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM www1@cdc.gov NR 10 TC 71 Z9 72 U1 0 U2 8 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 6 PY 2015 VL 64 IS 4 BP 95 EP 102 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CA6JP UT WOS:000349019200005 PM 25654611 ER PT J AU Homa, DM Neff, LJ King, BA Caraballo, RS Bunnell, RE Babb, SD Garrett, BE Sosnoff, CS Wang, LQ AF Homa, David M. Neff, Linda J. King, Brian A. Caraballo, Ralph S. Bunnell, Rebecca E. Babb, Stephen D. Garrett, Bridgette E. Sosnoff, Connie S. Wang, Lanqing TI Vital Signs: Disparities in Nonsmokers' Exposure to Secondhand Smoke - United States, 1999-2012 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID CURRENT CIGARETTE-SMOKING; ADULTS AB Background: Exposure to secondhand smoke (SHS) from burning tobacco causes disease and death in nonsmoking children and adults. No risk-free level of SHS exposure exists. Methods: National Health and Nutrition Examination Survey (NHANES) data from 1999-2012 were used to examine SHS exposure among the nonsmoking population aged >= 3 years. SHS exposure among nonsmokers was defined as a serum cotinine level (a metabolite of nicotine) of 0.05-10 ng/mL. SHS exposure was assessed overall and by age, sex, race/ethnicity, poverty level, education, and whether the respondent owned or rented their housing. Results: Prevalence of SHS exposure in nonsmokers declined from 52.5% during 1999-2000 to 25.3% during 2011-2012. During this period, declines were observed for all population subgroups, but disparities exist. During 2011-2012, SHS was highest among: children aged 3-11 years (40.6%), non-Hispanic blacks (46.8%), persons living below the poverty level (43.2%), and persons living in rental housing (36.8%). Among children aged 3-11 years, 67.9% of non-Hispanic blacks were exposed to SHS compared with 37.2% of non-Hispanic whites and 29.9% of Mexican Americans. Conclusion: Overall, SHS exposure in the United States has been reduced by half since 1999-2000. However, 58 million persons were still exposed to SHS during 2011-2012, and exposure remains higher among children, non-Hispanic blacks, those living in poverty, and those who rent their housing. Implications for Public Health Practice: Eliminating smoking in indoor spaces fully protects nonsmokers from SHS exposure; separating smokers from nonsmokers, cleaning the air and ventilating buildings cannot completely eliminate exposure. Continued efforts to promote implementation of comprehensive statewide laws prohibiting smoking in workplaces and public places, smoke-free policies in multiunit housing, and voluntary smoke-free home and vehicle rules are critical to protect nonsmokers from this preventable health hazard in the places they live, work, and gather. C1 [Homa, David M.; Neff, Linda J.; King, Brian A.; Caraballo, Ralph S.; Bunnell, Rebecca E.; Babb, Stephen D.; Garrett, Bridgette E.] CDC, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Sosnoff, Connie S.; Wang, Lanqing] CDC, Div Lab Sci, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA. RP Homa, DM (reprint author), CDC, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. EM dhoma@cdc.gov NR 22 TC 50 Z9 51 U1 0 U2 9 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 6 PY 2015 VL 64 IS 4 BP 103 EP 108 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CA6JP UT WOS:000349019200006 PM 25654612 ER PT J AU Jhung, MA Nelson, DI AF Jhung, Michael A. Nelson, Deborah I. TI Outbreaks of Avian Influenza A (H5N2), (H5N8), and (H5N1) Among Birds - United States, December 2014-January 2015 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Editorial Material ID INFECTION C1 [Jhung, Michael A.] CDC, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Nelson, Deborah I.] US Anim & Plant Hlth Inspect Serv, USDA, Ft Collins, CO USA. RP Jhung, MA (reprint author), CDC, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM mjhung@cdc.gov NR 3 TC 40 Z9 40 U1 0 U2 19 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD FEB 6 PY 2015 VL 64 IS 4 BP 111 EP 111 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CA6JP UT WOS:000349019200008 PM 25654614 ER PT J AU Laksanasopin, T Guo, TW Nayak, S Sridhara, AA Xie, S Olowookere, OO Cadinu, P Meng, FX Chee, NH Kim, J Chin, CD Munyazesa, E Mugwaneza, P Rai, AJ Mugisha, V Castro, AR Steinmiller, D Linder, V Justman, JE Nsanzimana, S Sia, SK AF Laksanasopin, Tassaneewan Guo, Tiffany W. Nayak, Samiksha Sridhara, Archana A. Xie, Shi Olowookere, Owolabi O. Cadinu, Paolo Meng, Fanxing Chee, Natalie H. Kim, Jiyoon Chin, Curtis D. Munyazesa, Elisaphane Mugwaneza, Placidie Rai, Alex J. Mugisha, Veronicah Castro, Arnold R. Steinmiller, David Linder, Vincent Justman, Jessica E. Nsanzimana, Sabin Sia, Samuel K. TI A smartphone dongle for diagnosis of infectious diseases at the point of care SO SCIENCE TRANSLATIONAL MEDICINE LA English DT Article ID SEROLOGIC TESTS; SYPHILIS; PHONE; PERFORMANCE; HEALTH AB This work demonstrates that a full laboratory-quality immunoassay can be run on a smartphone accessory. This low-cost dongle replicates all mechanical, optical, and electronic functions of a laboratory-based enzyme-linked immunosorbent assay (ELISA) without requiring any stored energy; all necessary power is drawn from a smartphone. Rwandan health care workers used the dongle to test whole blood obtained via fingerprick from 96 patients enrolling into care at prevention of mother-to-child transmission clinics or voluntary counseling and testing centers. The dongle performed a triplexed immunoassay not currently available in a single test format: HIV antibody, treponemal-specific antibody for syphilis, and nontreponemal antibody for active syphilis infection. In a blinded experiment, health care workers obtained diagnostic results in 15 min from our triplex test that rivaled the gold standard of laboratory-based HIV ELISA and rapid plasma reagin (a screening test for syphilis), with sensitivity of 92 to 100% and specificity of 79 to 100%, consistent with needs of current clinical algorithms. Patient preference for the dongle was 97% compared to laboratory-based tests, with most pointing to the convenience of obtaining quick results with a single fingerprick. This work suggests that coupling microfluidics with recent advances in consumer electronics can make certain laboratory-based diagnostics accessible to almost any population with access to smartphones. C1 [Laksanasopin, Tassaneewan; Guo, Tiffany W.; Nayak, Samiksha; Sridhara, Archana A.; Xie, Shi; Olowookere, Owolabi O.; Cadinu, Paolo; Meng, Fanxing; Chee, Natalie H.; Kim, Jiyoon; Chin, Curtis D.; Sia, Samuel K.] Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA. [Munyazesa, Elisaphane; Mugisha, Veronicah] Mailman Sch Publ Hlth, ICAP Rwanda, Kigali, Rwanda. [Mugwaneza, Placidie; Nsanzimana, Sabin] Rwanda Biomed Ctr, Inst HIV Dis Prevent & Control, Kigali, Rwanda. [Rai, Alex J.] Columbia Univ, Dept Pathol & Cell Biol, New York, NY 10032 USA. [Castro, Arnold R.] Ctr Dis Control & Prevent, Lab Reference & Res Branch, Atlanta, GA 30333 USA. [Steinmiller, David; Linder, Vincent] OPKO Diagnost LLC, Woburn, MA 01801 USA. [Justman, Jessica E.] Columbia Univ, Mailman Sch Publ Hlth, ICAP, New York, NY 10032 USA. RP Sia, SK (reprint author), Columbia Univ, Dept Biomed Engn, 351 Engn Terrace,1210 Amsterdam Ave, New York, NY 10027 USA. EM ss2735@columbia.edu FU Saving Lives at Birth transition grant (USAID, Gates Foundation, Government of Norway, Grand Challenges Canada, and the World Bank); Wallace H. Coulter Foundation; Royal Thai Government Scholarship; Columbia University Medical Scientist Training Program FX Saving Lives at Birth transition grant (USAID, Gates Foundation, Government of Norway, Grand Challenges Canada, and the World Bank), Wallace H. Coulter Foundation, Royal Thai Government Scholarship (T.L.), and Columbia University Medical Scientist Training Program (T.W.G.). NR 38 TC 61 Z9 62 U1 10 U2 64 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 1946-6234 EI 1946-6242 J9 SCI TRANSL MED JI Sci. Transl. Med. PD FEB 4 PY 2015 VL 7 IS 273 AR 273re1 DI 10.1126/scitranslmed.aaa0056 PG 9 WC Cell Biology; Medicine, Research & Experimental SC Cell Biology; Research & Experimental Medicine GA CB5XI UT WOS:000349700900004 PM 25653222 ER PT J AU Habib, MA Soofi, S Sheraz, A Bhatti, ZS Okayasu, H Zaidi, SZ Molodecky, NA Pallansch, MA Sutter, RW Bhutta, ZA AF Habib, M. A. Soofi, S. Sheraz, A. Bhatti, Z. S. Okayasu, H. Zaidi, S. Z. Molodecky, N. A. Pallansch, M. A. Sutter, R. W. Bhutta, Zulfigar A. TI Zinc supplementation fails to increase the immunogenicity of oral poliovirus vaccine: A randomized controlled trial SO VACCINE LA English DT Article DE Vaccine response; Poliomyelitis; Zinc supplementation; Randomized controlled trial ID VITAMIN-A SUPPLEMENTATION; HEPATITIS-B VACCINATION; DEVELOPING-COUNTRIES; PERSISTENT DIARRHEA; PREMATURE-INFANTS; ANTIBODY-RESPONSE; IMMUNE-RESPONSES; EXPANDED PROGRAM; PLASMA ZINC; CHILDREN AB Background: Polio eradication remains a challenge in Pakistan and the causes for the failure to eradicate poliomyelitis are complex. Undernutrition and micronutrient deficiencies, especially zinc deficiency, are major public health problems in Pakistan and could potentially affect the response to enteric vaccines, including oral poliovirus vaccine (OPV). Objective: To assess the impact of zinc supplementation among infants on immune response to oral poliovirus vaccine (OPV). Methods: A double-blind, randomized placebo-controlled trial was conducted in newborns (aged 0-14 days). Subjects were assigned to either receive 10 mg of zinc or placebo supplementation daily for 18 weeks. Both groups received OPV doses at birth, at 6 weeks, 10 weeks and 14 weeks. Data was collected on prior immunization status, diarrheal episodes, breastfeeding practices and anthropometric measurements at recruitment and at 6 and 18 weeks. Blood samples were similarly collected to determine the antibody response to OPV and for micronutrient analysis. Logistic regression was used to determine the relationship between seroconversion and zinc status. Results: Overall, 404 subjects were recruited. At recruitment, seropositivity was already high for poliovirus (PV) serotype 1 (zinc: 91.1%; control: 90.5%) and PV2 (90.0%; 92.7%), with lower estimates for PV3 (70.0%; 64.8%). By week 18, the proportion of subjects with measured zinc levels in the normal range (i.e. >= 60 mu g/dL) was significantly greater in the intervention group compared to the control group (71.9%; 27.4%; p < 0.001). No significant difference in seroconversion was demonstrated between the groups for PV1, PV2, or PV3. Conclusions: There was no effect of zinc supplementation on OPV immunogenicity. These conclusions were confirmed when restricting the analysis to those with measured higher zinc levels. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Habib, M. A.; Soofi, S.; Sheraz, A.; Bhatti, Z. S.; Bhutta, Zulfigar A.] Aga Khan Univ, Karachi 74800, Pakistan. [Okayasu, H.; Molodecky, N. A.; Sutter, R. W.] WHO, CH-1211 Geneva 27, Switzerland. [Pallansch, M. A.] Ctr Dis Control & Prevent CDC, Atlanta, GA USA. [Zaidi, S. Z.] NIH, Islamabad, Pakistan. RP Bhutta, ZA (reprint author), Aga Khan Univ, Div Women & Child Hlth, Stadium Rd, Karachi 74800, Pakistan. EM zulficiar.bhutta@aku.edu FU World Health Organization (WHO) FX The study was funded by World Health Organization (WHO). NR 44 TC 3 Z9 3 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD FEB 4 PY 2015 VL 33 IS 6 BP 819 EP 825 DI 10.1016/j.vaccine.2014.12.001 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA CB4CP UT WOS:000349576100011 PM 25500307 ER PT J AU Kalb, SR Krilich, JC Dykes, JK Luquez, C Maslanka, SE Barr, JR AF Kalb, Suzanne R. Krilich, Joan C. Dykes, Janet K. Luquez, Carolina Maslanka, Susan E. Barr, John R. TI Detection of Botulinum Toxins A, B, E, and F in Foods by Endopep-MS SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY LA English DT Article DE botulism; Endopep-MS; botulinum toxins; mass spectromety ID MASS-SPECTROMETRY; SEROTYPE-A; NEUROTOXINS; SNAP-25; CLEAVES; VAMP/SYNAPTOBREVIN; PROTEOLYSIS; TETANUS; RELEASE; PROTEIN AB Botulism is caused by exposure to botulinum neurotoxins (BoNTs). BoNTs are proteins secreted by some species of clostridia; these neurotoxins are known to interfere with nerve impulse transmission, thus causing paralysis. Botulism may be contracted through consumption of food either naturally or intentionally contaminated with BoNT. The human lethal dose of BoNT is not known but is estimated to be between 0.1 and 70 mu g; thus, it is important to be able to detect small amounts of this toxin in foods to ensure food safety and to identify the source of an outbreak. Our laboratory previously reported on the development of Endopep-MS, a mass-spectrometric-based endopeptidase method for the detection and differentiation of BoNT. This method can detect BoNT at levels below the historic standard mouse bioassay in clinical samples such as serum, stool, and culture supernatants. We have now expanded this assay to detect BoNT in over 50 foods including representative products that were involved in actual botulism investigations. The foods tested by the Endopep-MS included those with various acidities, viscosities, and fat levels. Dairy and culturally diverse products were also included. This work demonstrates that the Endopep-MS method can be used to detect BoNT/A, /B, /E, and /F in foods at levels spiked below that of the limit of detection of the mouse bioassay. Furthermore, we successfully applied this method to investigate several foods associated with botulism outbreaks. C1 [Kalb, Suzanne R.; Barr, John R.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30341 USA. [Krilich, Joan C.] Ctr Dis Control & Prevent, Battelle Mem Inst, Atlanta, GA 30329 USA. [Dykes, Janet K.; Luquez, Carolina; Maslanka, Susan E.] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Enter Dis Lab Branch, Atlanta, GA 30329 USA. RP Barr, JR (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, 4770 Buford Highway Northeast, Atlanta, GA 30341 USA. EM jbarr@cdc.gov NR 26 TC 6 Z9 6 U1 1 U2 14 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0021-8561 EI 1520-5118 J9 J AGR FOOD CHEM JI J. Agric. Food Chem. PD FEB 4 PY 2015 VL 63 IS 4 BP 1133 EP 1141 DI 10.1021/jf505482b PG 9 WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology SC Agriculture; Chemistry; Food Science & Technology GA CA8AG UT WOS:000349138300011 ER PT J AU Kim, DK Bridges, CB Harriman, KH AF Kim, David K. Bridges, Carolyn B. Harriman, Kathleen H. CA Advisory Comm Immunization Practic TI Advisory Committee on Immunization Practices Recommended Immunization Schedule for Adults Aged 19 Years or Older: United States, 2015 SO ANNALS OF INTERNAL MEDICINE LA English DT Article ID PNEUMOCOCCAL POLYSACCHARIDE VACCINE; PRACTICES ACIP; CONJUGATE VACCINE; PREVENTION C1 [Kim, David K.; Bridges, Carolyn B.; Harriman, Kathleen H.; Advisory Comm Immunization Practic] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Kim, DK (reprint author), Ctr Dis Control & Prevent, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,Mailstop A-19, Atlanta, GA 30333 USA. EM dkim@cdc.gov NR 10 TC 17 Z9 20 U1 0 U2 1 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA SN 0003-4819 EI 1539-3704 J9 ANN INTERN MED JI Ann. Intern. Med. PD FEB 3 PY 2015 VL 162 IS 3 BP 214 EP U130 DI 10.7326/M14-2755 PG 12 WC Medicine, General & Internal SC General & Internal Medicine GA CC1NP UT WOS:000350108100007 ER PT J AU Sriram, K Lin, GX Jefferson, AM Stone, S Afshari, A Keane, MJ McKinney, W Jackson, M Chen, BT Schwegler-Berry, D Cumpston, A Cumpston, JL Roberts, JR Frazer, DG Antonini, JM AF Sriram, Krishnan Lin, Gary X. Jefferson, Amy M. Stone, Samuel Afshari, Aliakbar Keane, Michael J. McKinney, Walter Jackson, Mark Chen, Bean T. Schwegler-Berry, Diane Cumpston, Amy Cumpston, Jared L. Roberts, Jenny R. Frazer, David G. Antonini, James M. TI Modifying welding process parameters can reduce the neurotoxic potential of manganese-containing welding fumes SO TOXICOLOGY LA English DT Article DE Manganese; Neurotoxicity; Parkinson's disease; Parkinsonism; Prevention; Welding ID EARLY-ONSET PARKINSONISM; NECROSIS-FACTOR-ALPHA; DOPAMINERGIC NEUROTOXICITY; MICROGLIAL ACTIVATION; INHALATION EXPOSURE; SIGNAL INTENSITIES; OXIDATIVE STRESS; TNF RECEPTORS; BRAIN; DISEASE AB Welding fumes (WF) are a complex mixture of toxic metals and gases, inhalation of which can lead to adverse health effects among welders. The presence of manganese (Mn) in welding electrodes is cause for concern about the potential development of Parkinson's disease (PD)-like neurological disorder. Consequently, from an occupational safety perspective, there is a critical need to prevent adverse exposures to WF. As the fume generation rate and physicochemical characteristics of welding aerosols are influenced by welding process parameters like voltage, current or shielding gas, we sought to determine if changing such parameters can alter the fume profile and consequently its neurotoxic potential. Specifically, we evaluated the influence of voltage on fume composition and neurotoxic outcome. Rats were exposed by whole-body inhalation (40 mg/m(3); 3 h/day x 5 d/week x 2 weeks) to fumes generated by gas-metal arc welding using stainless steel electrodes (GMA-SS) at standard/regular voltage (25 V; RVSS) or high voltage (30 V; HVSS). Fumes generated under these conditions exhibited similar particulate morphology, appearing as chain-like aggregates; however, HVSS fumes comprised of a larger fraction of ultrafine particulates that are generally considered to be more toxic than their fine counterparts. Paradoxically, exposure to HVSS fumes did not elicit dopaminergic neurotoxicity, as monitored by the expression of dopaminergic and PD-related markers. We show that the lack of neurotoxicity is due to reduced solubility of Mn in HVSS fumes. Our findings show promise for process control procedures in developing prevention strategies for Mn-related neurotoxicity during welding; however, it warrants additional investigations to determine if such modifications can be suitably adapted at the workplace to avert or reduce adverse neurological risks. Published by Elsevier Ireland Ltd. C1 [Sriram, Krishnan; Lin, Gary X.; Jefferson, Amy M.; Stone, Samuel; Afshari, Aliakbar; Keane, Michael J.; McKinney, Walter; Jackson, Mark; Chen, Bean T.; Schwegler-Berry, Diane; Cumpston, Amy; Cumpston, Jared L.; Roberts, Jenny R.; Frazer, David G.; Antonini, James M.] Natl Inst Occupat Safety & Hlth, Ctr Dis Control & Prevent, Hlth Effects Lab Div, Morgantown, WV 26505 USA. RP Sriram, K (reprint author), CDC NIOSH, Toxicol & Mol Biol Branch, Mailstop L-3014,1095 Willowdale Rd, Morgantown, WV 26505 USA. EM kos4@cdc.gov FU NIOSH [9782ZBDH] FX This work was funded by a NIOSH intramural grant (NIOSH ID# 9782ZBDH) to K.S. NR 54 TC 4 Z9 4 U1 7 U2 16 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD FEB 3 PY 2015 VL 328 BP 168 EP 178 DI 10.1016/j.tox.2014.12.015 PG 11 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA CB8LQ UT WOS:000349881500020 PM 25549921 ER PT J AU van Griensven, F Holtz, TH Thienkrua, W Chonwattana, W Wimonsate, W Chaikummao, S Varangrat, A Chemnasiri, T Sukwicha, W Curlin, ME Samandari, T Chitwarakorn, A Mock, PA AF van Griensven, Frits Holtz, Timothy H. Thienkrua, Warunee Chonwattana, Wannee Wimonsate, Wipas Chaikummao, Supaporn Varangrat, Anchalee Chemnasiri, Tareerat Sukwicha, Wichuda Curlin, Marcel E. Samandari, Taraz Chitwarakorn, Anupong Mock, Philip A. TI Temporal trends in HIV-1 incidence and risk behaviours in men who have sex with men in Bangkok, Thailand, 2006-13: an observational study SO LANCET HIV LA English DT Article ID DRUG-USERS; INFECTION; PREVENTION; EPIDEMIC; METHAMPHETAMINE AB Background HIV-1 incidence in men who have sex with men (MSM) is often difficult to estimate. We therefore assessed temporal trends in HIV-1 incidence and behavioural risk factors in MSM in Bangkok, Thailand, from 2006 to 2013. Methods In this observational study, we used data for clients attending the Silom Community Clinic for voluntary counselling and testing (VCT) services and from the Bangkok MSM Cohort Study (BMCS) to investigate trends in HIV incidence per 100 person-years per quarter in both cohorts. During VCT, basic demographic data were gathered at registration. However, no behavioural risk data were gathered. In the BMCS, we gathered demographic and behavioural data at baseline and at regular study visits using audio computer-assisted self-interviewing. Questions were included about potential risk factors such as drug use, sexual practices, and how often condoms were used. We also analysed behavioural risk factors in the BMCS cohort, using a restricted cubic spline function for time. Findings From 2006 to 2013, 8176 MSM came for VCT; 1999 (24%) clients were initially seronegative and returned for another test. 235 (12%) individuals seroconverted. The overall HIV-1 incidence was 5.5 per 100 person-years (95% CI 4.8-6.3), with an increasing trend (adjusted p=0.02). In the BMCS, 1372 people were seronegative at baseline; 1259 (92%) had more than one follow-up test and 238 (17%) seroconverted. The overall HIV-1 incidence was 5.3 per 100 person-years (95% CI 4.7-6.1), with an increase and then a decline (inverted U-shaped curve, p=0.0001). Individuals aged 21 years and younger were at significantly higher risk of HIV infection than were those aged 30 years and older in the in the VCT (rate ratio 2.29, 95% CI 1.88-2.78, p<0.0001) and BMCS cohorts (1.99, 1.50-2.65, p<0.0001). Overall, drug use (p=0.03), drug use to enhance sex (p=0.0006), use of drugs for erectile dysfunction (p<0.0001), and 100% condom use (p<0.0001) increased over time, whereas the proportion of individuals reporting receptive anal intercourse decreased (p=0.004). Interpretation With a sustained high HIV-1 incidence and increasing drug use in MSM in Bangkok, we urgently need innovative and acceptable HIV prevention interventions, especially for young MSM. C1 [van Griensven, Frits; Holtz, Timothy H.; Thienkrua, Warunee; Chonwattana, Wannee; Wimonsate, Wipas; Chaikummao, Supaporn; Varangrat, Anchalee; Chemnasiri, Tareerat; Sukwicha, Wichuda; Curlin, Marcel E.; Mock, Philip A.] Thailand Minist Publ Hlth US Ctr Dis Control & Pr, Nonthaburi 11000, Thailand. [van Griensven, Frits; Holtz, Timothy H.; Curlin, Marcel E.; Samandari, Taraz] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. [van Griensven, Frits] Univ Calif San Francisco, Div Prevent Med & Publ Hlth, San Francisco, CA 94143 USA. [Chitwarakorn, Anupong] Thai Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. RP Holtz, TH (reprint author), Minist Publ Hlth, Thailand Minist Publ Hlth US Ctr Dis Control & Pr, DDC 7 Bldg,4th Floor,Soi 4, Nonthaburi 11000, Thailand. EM tholtz@cdc.gov FU US Centers for Disease Control and Prevention FX The US Centers for Disease Control and Prevention funded the research. We thank the clients of Silom Community Clinic and the participants of the BMCS for their time and efforts; and the staff at the Silom Community Clinic for their dedication and expertise, without which this research could not be possible. The data in this study have been presented previously at the Conference on Retroviruses and Opportunistic Infections, Boston, MA, USA, March 3-6, 2014, abstract number 1026. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the CDC. NR 28 TC 6 Z9 6 U1 0 U2 0 PU ELSEVIER INC PI SAN DIEGO PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 2352-3018 J9 LANCET HIV JI Lancet HIV PD FEB PY 2015 VL 2 IS 2 BP E64 EP E70 DI 10.1016/S2352-3018(14)00031-9 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CU8KR UT WOS:000363791800008 PM 26424462 ER PT J AU Acosta, LM Soffer, N Divjan, A McGraw-Boitnotte, M Sobek, E Lemons, AR Perzanowski, MS Green, BJ AF Acosta, Luis M. Soffer, Nitzan Divjan, Adnan McGraw-Boitnotte, Merissa Sobek, Edward Lemons, Angela R. Perzanowski, Matthew S. Green, Brett J. TI Dustborne Fungal Diversity in Middle-Income Homes in New York City and Determinants for Domestic Exposure SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI) CY FEB 20-24, 2015 CL Houston, TX SP Amer Acad Allergy, Asthma & Immunol C1 [Acosta, Luis M.; Soffer, Nitzan; Divjan, Adnan; Perzanowski, Matthew S.] Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, New York, NY USA. [McGraw-Boitnotte, Merissa; Sobek, Edward] Assured Bio Labs, Oak Ridge, TN USA. [Lemons, Angela R.; Green, Brett J.] NIOSH, CDC, ACIB, Morgantown, WV USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0091-6749 EI 1097-6825 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD FEB PY 2015 VL 135 IS 2 SU S MA 55 BP AB18 EP AB18 PG 1 WC Allergy; Immunology SC Allergy; Immunology GA CR2BN UT WOS:000361129600056 ER PT J AU Green, BJ Nayak, AP Croston, TL Lemons, AR Marshall, NB Goldsmith, WT Kashon, M Law, BF Wagner, LM Long, CM Germolec, DM Beezhold, DH AF Green, Brett J. Nayak, Ajay P. Croston, Tara L. Lemons, Angela R. Marshall, Nikki B. Goldsmith, W. Travis Kashon, Michael Law, Brandon F. Wagner, Lauren M. Long, Carrie M. Germolec, Dori M. Beezhold, Donald H. TI Fungal Viability Is Essential in Modulating of Adaptive Immune Responses in Mice SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI) CY FEB 20-24, 2015 CL Houston, TX SP Amer Acad Allergy, Asthma & Immunol C1 [Green, Brett J.; Nayak, Ajay P.; Croston, Tara L.; Lemons, Angela R.; Marshall, Nikki B.; Law, Brandon F.; Wagner, Lauren M.; Long, Carrie M.; Beezhold, Donald H.] NIOSH, CDC, ACIB, Morgantown, WV USA. [Goldsmith, W. Travis] NIOSH, CDC, PPRB, Morgantown, WV USA. [Kashon, Michael] NIOSH, CDC, BEB, Morgantown, WV USA. [Germolec, Dori M.] NIEHS, NTP, Res Triangle Pk, NC 27709 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0091-6749 EI 1097-6825 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD FEB PY 2015 VL 135 IS 2 SU S MA 56 BP AB18 EP AB18 PG 1 WC Allergy; Immunology SC Allergy; Immunology GA CR2BN UT WOS:000361129600057 ER PT J AU Nayak, AP Green, BJ Croston, TL Lemons, AR Marshall, NB Goldsmith, WT Kashon, M Law, BF Wagner, LM Long, CM Germolec, DM Beezhold, DH AF Nayak, Ajay P. Green, Brett J. Croston, Tara L. Lemons, Angela R. Marshall, Nikki B. Goldsmith, W. Travis Kashon, Michael Law, Brandon F. Wagner, Lauren M. Long, Carrie M. Germolec, Dori M. Beezhold, Donald H. TI Characterization of Antigen Presenting Cells in a Murine Subchronic Fungal Exposure Model SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI) CY FEB 20-24, 2015 CL Houston, TX SP Amer Acad Allergy, Asthma & Immunol C1 [Nayak, Ajay P.; Green, Brett J.; Croston, Tara L.; Lemons, Angela R.; Marshall, Nikki B.; Law, Brandon F.; Wagner, Lauren M.; Long, Carrie M.; Beezhold, Donald H.] NIOSH, CDC, ACIB, Morgantown, WV USA. [Goldsmith, W. Travis] NIOSH, CDC, PPRB, Morgantown, WV USA. [Kashon, Michael] NIOSH, CDC, BEB, Morgantown, WV USA. [Germolec, Dori M.] NIEHS, NTP, Res Triangle Pk, NC 27709 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0091-6749 EI 1097-6825 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD FEB PY 2015 VL 135 IS 2 SU S MA 59 BP AB19 EP AB19 PG 1 WC Allergy; Immunology SC Allergy; Immunology GA CR2BN UT WOS:000361129600060 ER PT J AU Soffer, N Green, BJ Acosta, LM Divjan, A Sobek, E McGraw-Boitnotte, M Lemons, AR Miller, R Rundle, A Jacobson, J Goldstein, I Perzanowski, MS AF Soffer, Nitzan Green, Brett J. Acosta, Luis M. Divjan, Adnan Sobek, Edward McGraw-Boitnotte, Merissa Lemons, Angela R. Miller, Rachel Rundle, Andrew Jacobson, Judith Goldstein, Inge Perzanowski, Matthew S. TI Alternaria alternata Fungal Exposure Associated with Increased Fractional Exhaled Nitric Oxide Among Children in New York City SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI) CY FEB 20-24, 2015 CL Houston, TX SP Amer Acad Allergy, Asthma & Immunol C1 [Soffer, Nitzan; Acosta, Luis M.; Divjan, Adnan; Perzanowski, Matthew S.] Columbia Univ, Dept Environm Hlth Sci, Mailman Sch Publ Hlth, New York, NY USA. [Green, Brett J.; Lemons, Angela R.] NIOSH, CDC, ACIB, Morgantown, WV USA. [Sobek, Edward; McGraw-Boitnotte, Merissa] Assured Bio Labs, Oak Ridge, TN USA. [Miller, Rachel] Columbia Univ, Div Pulm Allergy & Crit Care Med, New York, NY USA. [Miller, Rachel; Rundle, Andrew; Jacobson, Judith; Goldstein, Inge] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0091-6749 EI 1097-6825 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD FEB PY 2015 VL 135 IS 2 SU S MA 54 BP AB17 EP AB17 PG 1 WC Allergy; Immunology SC Allergy; Immunology GA CR2BN UT WOS:000361129600055 ER PT J AU McConville, C Smith, JM McCoy, CF Srinivasan, P Mitchell, J Holder, A Otten, RA Butera, S Doncel, GF Friend, DR Malcolm, RK AF McConville, Christopher Smith, James M. McCoy, Clare F. Srinivasan, Priya Mitchell, James Holder, Angela Otten, Ron A. Butera, Salvatore Doncel, Gustavo F. Friend, David R. Malcolm, R. Karl TI Lack of in vitro-in vivo correlation for a UC781-releasing vaginal ring in macaques SO DRUG DELIVERY AND TRANSLATIONAL RESEARCH LA English DT Article DE UC781; Antiretroviral; Vaginal ring; HIV microbicide; In vivo-in vitro correlation ID REVERSE-TRANSCRIPTASE INHIBITOR; INTRAVAGINAL RINGS; HIV MICROBICIDE; SUSTAINED DELIVERY; RHESUS MACAQUES; UC781; RELEASE; PHARMACOKINETICS; TENOFOVIR; TYPE-1 AB This study describes the preclinical development of a matrix-type silicone elastomer vaginal ring device designed to provide controlled release of UC781, a non-nucleoside reverse transcriptase inhibitor. Testing of both human-and macaque-sized rings in a sink condition in vitro release model demonstrated continuous UC781 release in quantities considered sufficient to maintain vaginal fluid concentrations at levels 82-860-fold higher than the in vitro IC50 (2.0 to 10.4 nM) and therefore potentially protect against mucosal transmission of HIV. The 100-mg UC781 rings were well tolerated in pig-tailed macaques, did not induce local inflammation as determined by cytokine analysis and maintained median concentrations in vaginal fluids of UC781 in the range of 0.27 to 5.18 mM during the course of the 28-day study. Analysis of residual UC781 content in rings after completion of both the in vitro release andmacaque pharmacokinetic studies revealed that 57 and 5 mg of UC781 was released, respectively. The pharmacokinetic analysis of a 100-mg UC781 vaginal ring in pig-tailed macaques showed poor in vivo-in vitro correlation, attributed to the very poor solubility of UC781 in vaginal fluid and resulting in a dissolution-controlled drug release mechanism rather than the expected diffusion-controlled mechanism. C1 [McConville, Christopher; McCoy, Clare F.; Malcolm, R. Karl] Queens Univ Belfast, Sch Pharm, Belfast BT9 7BL, Antrim, North Ireland. [Smith, James M.; Srinivasan, Priya; Mitchell, James; Holder, Angela] Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, Natl Ctr HIV,STD,TB Prevent,CCID, Atlanta, GA USA. [Otten, Ron A.] Ctr Dis Control & Prevent, Off Sci Integr, Atlanta, GA USA. [Butera, Salvatore] Scripps Res Inst, Ctr HIV AIDS Vaccine Immunol & Immunogen Discover, La Jolla, CA 92037 USA. [Doncel, Gustavo F.; Friend, David R.] Eastern Virginia Med Sch, Dept Obstet & Gynaecol, CONRAD, Arlington, VA USA. [McConville, Christopher] Wolverhampton Univ, Fac Sci & Engn, Sch Pharm, Wolverhampton WV1 1LY, W Midlands, England. RP McConville, C (reprint author), Wolverhampton Univ, Fac Sci & Engn, Sch Pharm, Wulfran St, Wolverhampton WV1 1LY, W Midlands, England. EM C.Mcconville@wlv.ac.uk FU US Agency for International Development (USAID) [GPO-A-00-08-00005-00] FX CONRAD contributions were supported by a cooperative agreement (GPO-A-00-08-00005-00) with the US Agency for International Development (USAID). The views of the authors do not necessarily represent those of CONRAD or USAID. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 36 TC 2 Z9 2 U1 5 U2 7 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 2190-393X EI 2190-3948 J9 DRUG DELIV TRANSL RE JI Drug Deliv. Transl. Res. PD FEB PY 2015 VL 5 IS 1 BP 27 EP 37 DI 10.1007/s13346-015-0216-4 PG 11 WC Instruments & Instrumentation; Medicine, Research & Experimental; Pharmacology & Pharmacy SC Instruments & Instrumentation; Research & Experimental Medicine; Pharmacology & Pharmacy GA CM0MC UT WOS:000357371100004 PM 25787337 ER PT J AU Fan, AZ Strasser, SM Zhang, XY Fang, J Crawford, CG AF Fan, Amy Z. Strasser, Sheryl M. Zhang, Xingyou Fang, Jing Crawford, Carol G. TI State Socioeconomic Indicators and Self-Reported Hypertension Among US Adults, 2011 Behavioral Risk Factor Surveillance System SO PREVENTING CHRONIC DISEASE LA English DT Article ID BLOOD-PRESSURE; MULTILEVEL ANALYSIS; HEART-DISEASE; UNITED-STATES; HEALTH AB Introduction Hypertension is the leading cause of chronic disease and premature death in the United States. To date, most risk factors for hypertension have been identified at the individual (micro) level. The association of macro-level (area) socioeconomic factors and hypertension prevalence rates in the population has not been studied extensively. Methods We used the 2011 Behavioral Risk Factor Surveillance System to examine whether state socioeconomic status (SES) indicators predict the prevalence of self-reported hypertension. Quintiles of state median household income, unemployment rate among the population aged 16 to 64 years, and the proportion of the population under the national poverty line were used as the proxy for state SES. Hypertension status was determined by the question " Have you ever been told by a doctor, nurse, or other health professional that you have high blood pressure?" Logistic regression was used to assess the relationship between state SES and hypertension with adjustment for individual covariates (demographic and socioeconomic factors and lifestyle behaviors). Results States with a median household income of $ 43,225 or less (odds ratio [95% confidence interval] = 1.16 [1.08-1.25]) and states with 18.7% or more of residents living below the poverty line (odds ratio [95% confidence interval] = 1.14 [1.04-1.24]) had a higher prevalence of hypertension than states with the most residents in the most advantageous quintile of the indicators. Conclusion The observed state SES-hypertension association indicates that area SES may contribute to the burden of hypertension in community- dwelling adults. C1 [Strasser, Sheryl M.] Georgia State Univ, Sch Publ Hlth, Atlanta, GA 30303 USA. [Zhang, Xingyou; Fang, Jing; Crawford, Carol G.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. RP Fan, AZ (reprint author), Ctr Dis Control & Prevent, Populat Hlth Surveillance Branch, Div Populat Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy NE,Mail Stop F64, Atlanta, GA 30341 USA. EM afan@cdc.gov NR 23 TC 3 Z9 3 U1 0 U2 4 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD FEB PY 2015 VL 12 AR E27 DI 10.5888/pcd12.140353 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CL0YH UT WOS:000356668500015 PM 25719217 ER PT J AU Pitcher, TJ Sarathy, VV Matsui, K Gromowski, GD Huang, CYH Barrett, ADT AF Pitcher, Trevor J. Sarathy, Vanessa V. Matsui, Kiyohiko Gromowski, Gregory D. Huang, Claire Y-H Barrett, Alan D. T. TI Functional analysis of dengue virus (DENV) type 2 envelope protein domain 3 type-specific and DENV complex-reactive critical epitope residues SO JOURNAL OF GENERAL VIROLOGY LA English DT Article ID MONOCLONAL-ANTIBODY; HEPARAN-SULFATE; NEUTRALIZATION; BINDING; CELLS; GLYCOPROTEIN; ORGANIZATION; REPLICATION; INFECTION; FUSION AB The dengue virus (DENV) envelope protein domain 3 (ED3) is the target of potent virus neutralizing antibodies. The DENV-2 ED3 contains adjacent type-specific and DENV complex-reactive antigenic sites that are composed of a small number of residues that were previously demonstrated to be critical for antibody binding. Site-directed mutagenesis of a DENV-2 16681 infectious clone was used to mutate critical residues in the DENV-2 type-specific (K305A and P384A) and DENV complex-reactive (K310A) antigenic sites. The K305A mutant virus multiplied like the parent virus in mosquito and mammalian cells, as did the P384A mutant virus, which required a compensatory mutation (G330D) for viability. However, the K310A mutant virus could not be recovered. The DENV-2 type-specific critical residue mutations K305A and P384A+G330D reduced the ability of DENV-2 type-specific, but not DENV complex-reactive, mAbs to neutralize virus infectivity and this was directly correlated with mAb binding affinity to the rED3 mutants. C1 [Pitcher, Trevor J.; Sarathy, Vanessa V.; Matsui, Kiyohiko; Gromowski, Gregory D.; Barrett, Alan D. T.] Univ Texas Med Branch, Inst Human Infect & Immun, Sealy Ctr Vaccine Dev, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA. [Pitcher, Trevor J.; Sarathy, Vanessa V.; Matsui, Kiyohiko; Gromowski, Gregory D.; Barrett, Alan D. T.] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA. [Huang, Claire Y-H] US Dept HHS, Div Vector Borne Dis, Ctr Dis Control & Prevent, Publ Hlth Serv, Ft Collins, CO 80521 USA. RP Barrett, ADT (reprint author), Univ Texas Med Branch, Inst Human Infect & Immun, Sealy Ctr Vaccine Dev, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA. EM abarrett@utmb.edu FU NIAID [AI07536, AI060549] FX V. V. S. was supported by NIAID T32 postdoctoral fellowship (AI07536) and G. D. G. was supported by NIAID T32 predoctoral fellowship (AI060549). NR 21 TC 1 Z9 2 U1 0 U2 0 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 0022-1317 EI 1465-2099 J9 J GEN VIROL JI J. Gen. Virol. PD FEB PY 2015 VL 96 BP 288 EP 293 DI 10.1099/vir.0.070813-0 PN 2 PG 6 WC Biotechnology & Applied Microbiology; Virology SC Biotechnology & Applied Microbiology; Virology GA CJ8WR UT WOS:000355784700007 PM 25351518 ER PT J AU McDonald, JA Rishel, K Escobedo, MA Arellano, DE Cunningham, TJ AF McDonald, Jill A. Rishel, Karen Escobedo, Miguel A. Arellano, Danielle E. Cunningham, Timothy J. TI Obstetric emergencies at the United States-Mexico border crossings in El Paso, Texas SO REVISTA PANAMERICANA DE SALUD PUBLICA-PAN AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article DE Border areas; border health; pregnancy complications; emergency medical services; international cooperation; maternal welfare; Mexico; United States ID HEALTH-CARE; RESIDENTS AB Objective. To describe the frequency, characteristics, and patient outcomes for women who accessed Emergency Medical Services (EMS) for obstetric emergencies at the ports of entry (POE) between El Paso, Texas, United States of America, and Ciudad Juarez, Chihuahua, Mexico. Methods. A descriptive study of women 12-49 years of age for whom an EMS ambulance was called to an El Paso POE location from December 2008-April 2011 was conducted. Women were identified through surveillance of EMS records. EMS and emergency department (ED) records were abstracted for all women through December 2009 and for women with an obstetric emergency through April 2011. For obstetric patients admitted to the hospital, additional prenatal and birth characteristics were collected. Frequencies and proportions were estimated for each variable; differences between residents of the United States and Mexico were tested. Results. During December 2008-December 2009, 47.6% (68/143) of women receiving EMS assistance at an El Paso POE had an obstetric emergency, nearly 20 times the proportion for Texas overall. During December 2008-April 2011, 60.1% (66/109) of obstetric patients with ED records were admitted to hospital and 52 gave birth before discharge. Preterm birth (23.1%; No. = 12), low birth weight (9.6%; No. = 5), birth in transit (7.7%; No. = 4), and postpartum hemorrhage (5.8%; No. = 3) were common; fewer than one-half the women (46.2%; No. = 24) had evidence of prenatal care. Conclusions. The high proportion of obstetric EMS transports and high prevalence of complications in this population suggest a need for binational risk reduction efforts. C1 [McDonald, Jill A.; Rishel, Karen] New Mexico State Univ, Coll Hlth & Social Serv, Las Cruces, NM 88003 USA. [Escobedo, Miguel A.] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Natl Ctr Emerging Zoonot & Infect Dis, El Paso, TX USA. [Arellano, Danielle E.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Cunningham, Timothy J.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. RP McDonald, JA (reprint author), New Mexico State Univ, Coll Hlth & Social Serv, Las Cruces, NM 88003 USA. EM jillmcd@nmsu.edu FU Intramural CDC HHS [CC999999] NR 29 TC 0 Z9 0 U1 0 U2 1 PU PAN AMER HEALTH ORGANIZATION PI WASHINGTON PA 525 23RD ST NW, WASHINGTON, DC 20037 USA SN 1020-4989 J9 REV PANAM SALUD PUBL JI Rev. Panam. Salud Publica PD FEB PY 2015 VL 37 IS 2 BP 76 EP 82 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CJ1CH UT WOS:000355219000002 PM 25915011 ER PT J AU Gregg, E AF Gregg, Edward TI Obesity, diabetes, and the moving targets of healthy-years estimation SO LANCET DIABETES & ENDOCRINOLOGY LA English DT Editorial Material ID LIFETIME RISK; UNITED-STATES; OVERWEIGHT; MORTALITY; TRENDS C1 Ctr Dis Control & Prevent, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Gregg, E (reprint author), Ctr Dis Control & Prevent, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. EM edg7@cdc.gov NR 10 TC 2 Z9 2 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 2213-8587 J9 LANCET DIABETES ENDO JI Lancet Diabetes Endocrinol. PD FEB PY 2015 VL 3 IS 2 BP 93 EP 94 DI 10.1016/S2213-8587(14)70242-6 PG 3 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA CG1KG UT WOS:000353030900003 PM 25483221 ER PT J AU Grando, IM de Moraes, C Flannery, B Ramalho, WM Horta, MAP Pinho, DLM Nascimento, GL AF Grando, Indianara Maria de Moraes, Camile Flannery, Brendan Ramalho, Walter Massa Horta, Marco Aurelio P. Moura Pinho, Diana Lucia Nascimento, Gilmara Lima TI Impact of 10-valent pneumococcal conjugate vaccine on pneumococcal meningitis in children up to two years of age in Brazil SO CADERNOS DE SAUDE PUBLICA LA English DT Article DE Streptococcus pneumoniae; Meningitis; Vaccines ID POPULATION-BASED SURVEILLANCE; STREPTOCOCCUS-PNEUMONIAE; UNITED-STATES; BACTERIAL-MENINGITIS; DISEASE; INFECTIONS; INFANTS; YOUNGER; DECLINE; TRIAL AB The objective of this study was to analyze the impact of vaccination against Streptococcus pneumoniae on the morbidity and mortality from pneumococcal meningitis in children <= 2 years in Brazil, from 2007 to 2012. This is a descriptive study and ecological analysis using data from the Information System on Notifiable Diseases. Prevaccination (2007-2009) and post-vaccination (2011-2012) periods were defined to compare incidence rates and mortality. A total of 1,311 cases and 430 deaths were reported during the study period. Incidence decreased from 3.70/100,000 in 2007 to 1.84/100,000 in 2012, and mortality decreased from 1.30/100,000 to 0.40/100,000, or 50% and 69% respectively, with the greatest impact in the 6-11 month age group. This decrease in Pneumococcal meningitis morbidity and mortality rates two years after introduction of the 10-valent pneumococcal conjugate vaccine suggests its effectiveness. C1 [Grando, Indianara Maria; Moura Pinho, Diana Lucia] Univ Brasilia, Fac Ceilandia, Brasilia, DF, Brazil. [Grando, Indianara Maria; de Moraes, Camile] Minist Saude, Secretaria Vigilancia Saude, Brasilia, DF, Brazil. [de Moraes, Camile; Ramalho, Walter Massa; Nascimento, Gilmara Lima] Univ Brasilia, Brasilia, DF, Brazil. [Flannery, Brendan] Ctr Dis Control & Prevent, Global Immunizat Div, Atlanta, GA USA. [Horta, Marco Aurelio P.] Fundacao Oswaldo Cruz, Escola Nacl Saude Publ Sergio Arouca, Rio De Janeiro, Brazil. RP Grando, IM (reprint author), SQN 216 Bloco B,Apto 506, BR-70875020 Brasilia, DF, Brazil. EM indiamgrando@gmail.com RI Pinho, Diana Lucia Moura/K-5225-2013 OI Pinho, Diana Lucia Moura/0000-0003-4212-2340 FU Capes agency (Coordination for the Improvement of Higher Education) FX The authors wish to thank the Health Surveillance Secretariat of the Brazilian Ministry of Health for granting access to the database and the Capes agency (Coordination for the Improvement of Higher Education) for the research grant. NR 39 TC 4 Z9 5 U1 1 U2 4 PU CADERNOS SAUDE PUBLICA PI RIO DE JANIERO PA RUA LEOPOLDO BUHOES 1480, RIO DE JANIERO, RJ 210410210, BRAZIL SN 0102-311X EI 1678-4464 J9 CAD SAUDE PUBLICA JI Cad. Saude Publica PD FEB PY 2015 VL 31 IS 2 BP 276 EP 284 DI 10.1590/0102-311X00169913 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CF6IX UT WOS:000352661500008 PM 25760162 ER PT J AU Pride, KR Peel, JL Robinson, BF Busacker, A Grandpre, J Bisgard, KM Yip, FY Murphy, TD AF Pride, Kerry R. Peel, Jennifer L. Robinson, Byron F. Busacker, Ashley Grandpre, Joseph Bisgard, Kristine M. Yip, Fuyuen Y. Murphy, Tracy D. TI Association of short-term exposure to ground-level ozone and respiratory outpatient clinic visits in a rural location - Sublette County, Wyoming, 2008-2011 SO ENVIRONMENTAL RESEARCH LA English DT Article DE Ozone; Air pollution; Rural communities; Cold; Seasons ID EMERGENCY-DEPARTMENT VISITS; CASE-CROSSOVER ANALYSIS; AIR-POLLUTION; AMBIENT OZONE; ASTHMA; EPIDEMIOLOGY; ADMISSIONS; CHILDREN; CANADA AB Objective: Short-term exposure to ground-level ozone has been linked to adverse respiratory and other health effects; previous studies typically have focused on summer ground-level ozone in urban areas. During 2008-2011, Sublette County, Wyoming (population: similar to 10,000 persons), experienced periods of elevated ground-level ozone concentrations during the winter. This study sought to evaluate the association of daily ground-level ozone concentrations and health clinic visits for respiratory disease in this rural county. Methods: Clinic visits for respiratory disease were ascertained from electronic billing records of the two clinics in Sublette County for January 1, 2008-December 31, 2011. A time-stratified case-crossover design, adjusted for temperature and humidity, was used to investigate associations between ground-level ozone concentrations measured at one station and clinic visits for a respiratory health concern by using an unconstrained distributed lag of 0-3 days and single-day lags of 0 day, 1 day, 2 days, and 3 days. Results: The data set included 12,742 case-days and 43,285 selected control-days. The mean ground-level ozone observed was 47 +/- 8 ppb. The unconstrained distributed lag of 0-3 days was consistent with a null association (adjusted odds ratio [aOR]: 1.001; 95% confidence interval [CI]: 0.990-1.012); results for lags 0, 2, and 3 days were consistent with the null. However, the results for lag 1 were indicative of a positive association; for every 10-ppb increase in the 8-h maximum average ground-level ozone, a 3.0% increase in respiratory clinic visits the following day was observed (aOR: 1.031; 95% CI: 0.994-1.069). Season modified the adverse respiratory effects: ground-level ozone was significantly associated with respiratory clinic visits during the winter months. The patterns of results from all sensitivity analyzes were consistent with the a priori model. Conclusions: The results demonstrate an association of increasing ground-level ozone with an increase in clinic visits for adverse respiratory-related effects in the following day (lag day 1) in Sublette County; the magnitude was strongest during the winter months; this association during the winter months in a rural location warrants further investigation. Published by Elsevier Inc. C1 [Pride, Kerry R.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. [Pride, Kerry R.; Murphy, Tracy D.] Wyoming Dept Hlth, Cheyenne, WY 82002 USA. [Peel, Jennifer L.] Colorado State Univ, Dept Environm & Radiol Hlth Sci, Ft Collins, CO 80523 USA. [Robinson, Byron F.; Bisgard, Kristine M.] Ctr Dis Control & Prevent, Off Surveillance, Sci Educ & Profess Dev Program Off, Epidemiol & Lab Serv, Atlanta, GA 30333 USA. [Busacker, Ashley] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, Field Support Branch, Cheyenne, WY 82002 USA. [Grandpre, Joseph] Wyoming Dept Hlth, Chron Dis Epidemiol, Cheyenne, WY 82002 USA. [Yip, Fuyuen Y.] Ctr Dis Control & Prevent, Air Pollut & Resp Dis Branch, Atlanta, GA 30333 USA. RP Pride, KR (reprint author), Wyoming Dept Hlth, DACVPM, MPH, DVM, 6101 Yellowstone Rd,Suite 510, Cheyenne, WY 82002 USA. EM hgp3@cdc.gov NR 22 TC 4 Z9 4 U1 4 U2 12 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0013-9351 EI 1096-0953 J9 ENVIRON RES JI Environ. Res. PD FEB PY 2015 VL 137 BP 1 EP 7 DI 10.1016/j.envres.2014.10.033 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA CF1TO UT WOS:000352331000001 PM 25483412 ER PT J AU Velasquez, DE Wang, YH Jiang, BM AF Velasquez, Daniel E. Wang, Yuhuan Jiang, Baoming TI Inactivated human rotavirus vaccine induces heterotypic antibody response: Correction and development of IgG avidity assay SO HUMAN VACCINES & IMMUNOTHERAPEUTICS LA English DT Letter DE CDC-9; heterotypic protection; IRV; IgG-avidity; rotavirus ID IMMUNOGENICITY; IMMUNITY AB To improve lower efficacy among infants in low income countries and the safety (e.g., rare but severe intussusception) of live oral rotavirus vaccines, we have developed CDC-9 strain with G1P[8] specificity as a candidate inactivated rotavirus vaccine (IRV). This IRV of 3 doses elicits high titers of IgG, neutralizing activity to homotypic and heterotypic human strains and IgG avidity in guinea pigs, thus is a promising alternative to enhance global immunization against rotavirus in children. C1 [Velasquez, Daniel E.; Wang, Yuhuan; Jiang, Baoming] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA. RP Jiang, BM (reprint author), Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA. EM bxj4@cdc.gov NR 7 TC 1 Z9 1 U1 0 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 2164-5515 EI 2164-554X J9 HUM VACC IMMUNOTHER JI Human Vaccines Immunother. PD FEB PY 2015 VL 11 IS 2 BP 531 EP 533 DI 10.4161/21645515.2014.988553 PG 3 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA CF5RR UT WOS:000352615200042 PM 25692974 ER PT J AU Roux, L Pratt, M Lee, IM Bazzarre, T Buchner, D AF Roux, Larissa Pratt, Mike Lee, I-Min Bazzarre, Terry Buchner, David TI Does Age Modify the Cost-Effectiveness of Community-Based Physical Activity Interventions? SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH LA English DT Article DE exercise; health promotion; middle-age; economics ID AMERICAN-HEART-ASSOCIATION; OF-SPORTS-MEDICINE; PREVENTIVE-SERVICES; PUBLIC-HEALTH; OLDER-ADULTS; STROKE; LIFE; QUALITY; RISK; RECOMMENDATION AB Background: Community-based efforts to promote physical activity (PA) in adults have been found to be cost-effective in general, but it is unknown if this is true in middle-age specifically. Age group-specific economic evaluations could help inform the design and delivery of better and more tailored PA promotion. Methods: A Markov model was developed to estimate the cost-effectiveness (CE) of 7 exemplar community-level interventions to promote PA recommended by the Guide to Community Preventive Services, over a 20-year horizon. The CE of these interventions in 25- to 64-year-old adults was compared with their CE in middle-aged adults, aged 50 to 64 years. The robustness of the results was examined through sensitivity analyses. Results: Cost/QALY (quality-adjusted life year) of the evaluated interventions in 25- to 64-year-olds ranged from $42,456/QALY to $145,868/QALY. Interventions were more cost-effective in middle-aged adults, with CE ratios 38% to 47% lower than in 25- to 64-year-old adults. Sensitivity analyses showed greater than a 90% probability that the true CE of 4 of the 7 interventions was below $125,000/QALY in adults aged 50 to 64 years. Conclusion: The exemplar PA promotion interventions evaluated appeared to be especially cost-effective for middle-aged adults. Prioritizing such efforts to this age group is a good use of societal resources. C1 [Roux, Larissa] Richmond Olymp Oval, LifeMark Sport Med, Vancouver, BC, Canada. [Pratt, Mike] WHO, Collaborating Ctr Phys Act & Hlth Promot, CDC, Atlanta, GA USA. [Lee, I-Min] Harvard Univ, Sch Med, Dept Epidemiol, Boston, MA USA. [Bazzarre, Terry] Robert Wood Johnson Fdn, Princeton, NJ 08540 USA. [Buchner, David] Univ Illinois, Dept Kinesiol & Community Hlth, Urbana, IL USA. RP Roux, L (reprint author), Richmond Olymp Oval, LifeMark Sport Med, Vancouver, BC, Canada. EM larissaroux@me.com FU Robert Wood Johnson Foundation; CDC Foundation; Robert Wood Johnson Foundation, through the CDC Foundation [124432-0100-03] FX This scale of collaboration was made possible by the commitment and financial support of the Robert Wood Johnson Foundation and the CDC Foundation and their project officers.; This work was supported by a generous grant from the Robert Wood Johnson Foundation, through the CDC Foundation (Project #124432-0100-03). The overall project was entitled, Project MOVE: Measurement of the Value of Exercise: Economic analysis of community interventions to increase physical activity (Physical Inactivity and Sedentary Lifestyles). The project sought to improve public health public policy decision making by developing methods and tools that allowed for measuring, valuing, and comparing the health and economic impacts of physical activity promotion. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 53 TC 1 Z9 1 U1 1 U2 1 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1543-3080 EI 1543-5474 J9 J PHYS ACT HEALTH JI J. Phys. Act. Health PD FEB PY 2015 VL 12 IS 2 BP 224 EP 231 DI 10.1123/jpah.2013-0167 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CF7PP UT WOS:000352749100011 PM 24836847 ER PT J AU Lushniak, BD Alley, DE Ulin, B Graffunder, C AF Lushniak, Boris D. Alley, Dawn E. Ulin, Brigette Graffunder, Corinne TI The National Prevention Strategy: Leveraging Multiple Sectors to Improve Population Health SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material C1 [Lushniak, Boris D.] Acting Surg Gen, Washington, DC USA. [Lushniak, Boris D.] Natl Prevent Council, Washington, DC USA. [Alley, Dawn E.] Off Surg Gen, Washington, DC USA. [Ulin, Brigette] Ctr Dis Control & Prevent CDC, Off Natl Prevent Strategy, Atlanta, GA USA. [Graffunder, Corinne] CDC, Atlanta, GA 30333 USA. RP Ulin, B (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop D-28, Atlanta, GA 30329 USA. EM bcf8@cdc.gov NR 5 TC 3 Z9 3 U1 0 U2 2 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD FEB PY 2015 VL 105 IS 2 BP 229 EP 231 DI 10.2105/AJPH.2014.302257 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CE6CD UT WOS:000351922500021 PM 25521895 ER PT J AU Rodgers, LE Paulson, J Fowler, B Duffy, R AF Rodgers, Loren E. Paulson, John Fowler, Brian Duffy, Rosemary TI System for Rapid Assessment of Pneumonia and Influenza-Related Mortality-Ohio, 2009-2010 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article AB Rapid mortality surveillance is critical for state emergency preparedness. To enhance timeliness during the 2009-2010 influenza A H1N1 pandemic, the Ohio Department of Health activated a drop-down menu within Ohio's Electronic Death Registration System for reporting of pneumonia-or influenza-related deaths approximately 5 days postmortem. We used International Classification of Diseases-Tenth Revision (ICD-10) codes, available 2-3 months postmortem as the standard, and assessed their agreement with drop-down-menu codes for pneumonia-or influenza-related deaths. Among 56 660 Ohio deaths during September 2009-March 2010, agreement was 97.9% for pneumonia (kappa = 0.85) and 99.9% for influenza (kappa = 0.79). Sensitivity was 80.2% for pneumonia and 73.9% for influenza. Drop-down menu coding enhanced timeliness while maintaining high agreement with ICD-10 codes. C1 [Rodgers, Loren E.; Duffy, Rosemary] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Rodgers, Loren E.; Paulson, John; Fowler, Brian; Duffy, Rosemary] Ohio Dept Hlth, Columbus, OH 43266 USA. RP Rodgers, LE (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop A-19, Atlanta, GA 30333 USA. EM lrodgers@cdc.gov NR 7 TC 1 Z9 1 U1 0 U2 0 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD FEB PY 2015 VL 105 IS 2 BP 236 EP 239 DI 10.2105/AJPH.2014.302231 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CE6CD UT WOS:000351922500023 PM 25521902 ER PT J AU Collier, MG Bhaurla, SK Cuevas-Mota, J Armenta, RF Teshale, EH Garfein, RS AF Collier, Melissa G. Bhaurla, Sandeep K. Cuevas-Mota, Jazmine Armenta, Richard F. Teshale, Eyasu H. Garfein, Richard S. TI Awareness of HCV Infection Among Persons Who Inject Drugs in San Diego, California SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID C VIRUS-INFECTION; HEPATITIS-C; UNITED-STATES; USERS; PREVALENCE AB We asked persons who inject drugs questions about HCV, including past testing and diagnosis followed by HCV testing. Of 540 participants, 145 (27%) were anti-HCV positive, but of those who were positive, only 46 (32%) knew about their infection. Asking about previous HCV testing results yielded better results than did asking about prior HCV diagnosis. Factors associated with knowing about HCV infection included older age, HIV testing, and drug treatment. Comprehensive approaches to educating and screening this population for HCV need implementation. C1 [Collier, Melissa G.; Teshale, Eyasu H.] Ctr Dis Control & Prevent, Div Viral Hepatitis, Natl Ctr HIV Hepatitis STD & TB Prevent, Atlanta, GA 30329 USA. [Bhaurla, Sandeep K.; Cuevas-Mota, Jazmine; Armenta, Richard F.; Garfein, Richard S.] Univ Calif San Diego, Sch Med, Div Global Publ Hlth, San Diego, CA 92103 USA. RP Collier, MG (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, 1600 Clifton Rd NE,MS G-37, Atlanta, GA 30329 USA. EM mgcollier@cdc.gov FU Centers for Disease Control and Prevention [200 2007 21016] FX This study was funded by the Centers for Disease Control and Prevention (grant 200 2007 21016). NR 14 TC 1 Z9 1 U1 0 U2 1 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD FEB PY 2015 VL 105 IS 2 BP 302 EP 303 DI 10.2105/AJPH.2014.302245 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CE6CD UT WOS:000351922500034 PM 25521877 ER PT J AU Fowler, KA Gladden, RM Vagi, KJ Barnes, J Frazier, L AF Fowler, Katherine A. Gladden, R. Matthew Vagi, Kevin J. Barnes, Jamar Frazier, Leroy TI Increase in Suicides Associated With Home Eviction and Foreclosure During the US Housing Crisis: Findings From 16 National Violent Death Reporting System States, 2005-2010 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID TIME-TREND ANALYSIS; ECONOMIC RECESSION; DEPRESSION; HEALTH; RATES; IMPACT; RISK; LIFE AB Objectives. We aimed to determine the frequency, characteristics, and precipitating circumstances of eviction-and foreclosure-related suicides during the US housing crisis, which resulted in historically high foreclosures and increased evictions beginning in 2006. Methods. We examined all eviction-and foreclosure-related suicides in the years 2005 to 2010 in 16 states in the National Violent Death Reporting System, a surveillance system for all violent deaths within participating states that abstracts information across multiple investigative sources (e.g., law enforcement, coroners, medical examiners). Results. We identified 929 eviction-or foreclosure-related suicides. Eviction-and foreclosure-related suicides doubled from 2005 to 2010 (n = 88 in 2005; n = 176 in 2010), mostly because of foreclosure-related suicides, which increased 253% from 2005 (n = 30) to 2010 (n = 106). Most suicides occurred before the actual housing loss (79%), and 37% of decedents experienced acute eviction or foreclosure crises within 2 weeks of the suicide. Conclusions. Housing loss is a significant crisis that can precipitate suicide. Prevention strategies include support for those projected to lose homes, intervention before move-out date, training financial professionals to recognize warning signs, and strengthening population-wide suicide prevention measures during economic crises. C1 [Fowler, Katherine A.; Gladden, R. Matthew; Vagi, Kevin J.; Barnes, Jamar; Frazier, Leroy] Ctr Dis Control & Prevent, Div Violence Prevent, Atlanta, GA USA. RP Fowler, KA (reprint author), 4770 Buford Hwy NE,MS F-64, Atlanta, GA 30341 USA. EM vid5@cdc.gov NR 34 TC 13 Z9 15 U1 2 U2 12 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD FEB PY 2015 VL 105 IS 2 BP 311 EP 316 DI 10.2105/AJPH.2014.301945 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CE6CD UT WOS:000351922500036 PM 25033148 ER PT J AU Elbel, B Mijanovich, T Abrams, C Cantor, J Dunn, L Nonas, C Cappola, K Onufrak, S Park, S AF Elbel, Brian Mijanovich, Tod Abrams, Courtney Cantor, Jonathan Dunn, Lillian Nonas, Cathy Cappola, Kristin Onufrak, Stephen Park, Sohyun TI A Water Availability Intervention in New York City Public Schools: Influence on Youths' Water and Milk Behaviors SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID SUGAR-SWEETENED BEVERAGES; DRINKING-WATER; DENTAL-CARIES; US CHILDREN; BODY-WEIGHT; CONSUMPTION; ADOLESCENTS; TRIAL; PREVENTION; PROVISION AB Objectives. We determined the influence of "water jets" on observed water and milk taking and self-reported fluid consumption in New York City public schools. Methods. From 2010 to 2011, before and 3 months after water jet installation in 9 schools, we observed water and milk taking in cafeterias (mean 1000 students per school) and surveyed students in grades 5, 8, and 11 (n = 2899) in the 9 schools that received water jets and 10 schools that did not. We performed an observation 1 year after implementation (2011-2012) with a subset of schools. We also interviewed cafeteria workers regarding the intervention. Results. Three months after implementation we observed a 3-fold increase in water taking (increase of 21.63 events per 100 students; P <.001) and a much smaller decline in milk taking (-6.73 events per 100 students; P =.012), relative to comparison schools. At 1 year, relative to baseline, there was a similar increase in water taking and no decrease in milk taking. Cafeteria workers reported that the water jets were simple to clean and operate. Conclusions. An environmental intervention in New York City public schools increased water taking and was simple to implement. C1 [Elbel, Brian; Cantor, Jonathan] NYU, Sch Med, Dept Populat Hlth, New York, NY USA. [Elbel, Brian; Cantor, Jonathan] Robert Wagner Grad Sch Publ Serv, New York, NY USA. [Mijanovich, Tod] NYU, Steinhardt Sch, Dept Humanities & Social Sci Profess, New York, NY USA. [Abrams, Courtney] NYU, Sch Med, Dept Populat Hlth, New York, NY USA. [Dunn, Lillian; Nonas, Cathy; Cappola, Kristin] New York City Dept Hlth & Mental Hyg, New York, NY USA. [Onufrak, Stephen; Park, Sohyun] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Elbel, B (reprint author), NYU, Sch Med, 550 First Ave,VZ30,6th Floor,Off 626, New York, NY 10016 USA. EM brian.elbel@nyumc.org OI Elbel, Brian/0000-0003-1615-9430 FU Centers for Disease Control and Prevention (Nutrition and Obesity Policy Research and Evaluation Network) [1U48DP001904-01]; National Institutes of Health [R01HD070739] FX This study was funded by the Centers for Disease Control and Prevention (Nutrition and Obesity Policy Research and Evaluation Network supplement to 1U48DP001904-01) and the National Institutes of Health (award R01HD070739). NR 24 TC 7 Z9 7 U1 2 U2 13 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD FEB PY 2015 VL 105 IS 2 BP 365 EP 372 DI 10.2105/AJPH.2014.302221 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CE6CD UT WOS:000351922500044 PM 25521867 ER PT J AU Coffield, E Nihiser, AJ Sherry, B Economos, CD AF Coffield, Edward Nihiser, Allison J. Sherry, Bettylou Economos, Christina D. TI Shape Up Somerville: Change in Parent Body Mass Indexes During a Child-Targeted, Community-Based Environmental Change Intervention SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID OBESITY PREVENTION; PHYSICAL-ACTIVITY; WEIGHT; MASSACHUSETTS; NUTRITION; STUDENTS; PROGRAM; SERVICE; HEALTH; SCORE AB Objectives. We investigated the body mass index (BMI; weight in pounds/[height in inches](2) x 703) of parents whose children participated in Shape Up Somerville (SUS), a community-based participatory research study that altered household, school, and community environments to prevent and reduce childhood obesity. Methods. SUS was a nonrandomized controlled trial with 30 participating elementary schools in 3 Massachusetts communities that occurred from 2002 to 2005. It included first-, second-, and third-grade children. We used an inverse probability weighting estimator adjusted for clustering effects to isolate the influence of SUS on parent (n = 478) BMI. The model's dependent variable was the change in pre- and postintervention parent BMI. Results. SUS was significantly associated with decreases in parent BMIs. SUS decreased treatment parents' BMIs by 0.411 points (95% confidence interval = -0.725, -0.097) relative to control parents. Conclusions. The benefits of a community-based environmental change childhood obesity intervention can spill over to parents, resulting in decreased parental BMI. Further research is warranted to examine the effects of this type of intervention on parental health behaviors and health outcomes. C1 [Coffield, Edward; Nihiser, Allison J.; Sherry, Bettylou] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Economos, Christina D.] Tufts Univ, Gerald J & Dorothy R Friedman Sch Nutr Sci & Poli, Boston, MA 02111 USA. RP Coffield, E (reprint author), 220 Hofstra Univ, Hempstead, NY 11549 USA. EM edward.coffield@hofstra.edu FU Centers for Disease Control and Prevention (CDC); CDC [R06/CCR121519-01]; Blue Cross Blue Shield of Massachusetts; United Way of Mass Bay; US Potato Board; Stonyfield Farm; Dole Foods FX This study was conducted independently of any outside funding, including any previously allocated funds from the Centers for Disease Control and Prevention (CDC) and other sources to the Shape Up Somerville (SUS) research study. The SUS research study was funded by the CDC (grant R06/CCR121519-01 to C. D. E.). Additional unrestricted support for the SUS research study was provided by Blue Cross Blue Shield of Massachusetts, United Way of Mass Bay, the US Potato Board, Stonyfield Farm, and Dole Foods. NR 35 TC 4 Z9 4 U1 2 U2 7 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD FEB PY 2015 VL 105 IS 2 BP E83 EP E89 DI 10.2105/AJPH.2014.302361 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CE6CD UT WOS:000351922500017 PM 25521882 ER PT J AU Taylor, JL Lee, FK Yazdanpanah, GK Staropoli, JF Liu, M Carulli, JP Sun, C Dobrowolski, SF Hannon, WH Vogt, RF AF Taylor, Jennifer L. Lee, Francis K. Yazdanpanah, Golriz Khadem Staropoli, John F. Liu, Mei Carulli, John P. Sun, Chao Dobrowolski, Steven F. Hannon, W. Harry Vogt, Robert F. TI Newborn Blood Spot Screening Test Using Multiplexed Real-Time PCR to Simultaneously Screen for Spinal Muscular Atrophy and Severe Combined Immunodeficiency SO CLINICAL CHEMISTRY LA English DT Article ID T-CELL LYMPHOPENIA; 1ST 2 YEARS; COPY NUMBER; EXPERIENCE; DNA AB BACKGROUND: Spinal muscular atrophy (SMA) is a motor neuron disorder caused by the absence of a functional survival of motor neuron 1, telomeric (SMN1) gene. Type I SMA, a lethal disease of infancy, accounts for the majority of cases. Newborn blood spot screening (NBS) to detect severe combined immunodeficiency (SCID) has been implemented in public health laboratories in the last 5 years. SCID detection is based on real-time PCR assays to measure T-cell receptor excision circles (TREC), a byproduct of T-cell development. We modified a multiplexed real-time PCR TREC assay to simultaneously determine the presence or absence of the SMN1 gene from a dried blood spot (DBS) punch in a single reaction well. METHOD: An SMN1 assay using a locked nucleic acid probe was initially developed with cell culture and umbilical cord blood (UCB) DNA extracts, and then integrated into the TREC assay. DBS punches were placed in 96-well arrays, washed, and amplified directly using reagents specific for TREC, a reference gene [ribonuclease P/MRP 30kDa subunit (RPP30)], and the SMN1 gene. The assay was tested on DBS made from UCB units and from peripheral blood samples of SMA-affected individuals and their family members. RESULTS: DBS made from SMA-affected individuals showed no SMN1-specific amplification, whereas DBS made from all unaffected carriers and UCB showed SMN1 amplification above a well-defined threshold. TREC and RPP30 content in all DBS were within the age-adjusted expected range. CONCLUSIONS: SMA caused by the absence of SMN1 can be detected from the same DBS punch used to screen newborns for SCID. (C) 2014 American Association for Clinical Chemistry C1 [Taylor, Jennifer L.; Lee, Francis K.; Vogt, Robert F.] Ctr Dis Control & Prevent, Div Sci Lab, Newborn Screening & Mol Biol Branch, Atlanta, GA 30341 USA. [Yazdanpanah, Golriz Khadem; Hannon, W. Harry] CDC Fdn, Newborn Screening Translat Res Initiat, Atlanta, GA USA. [Staropoli, John F.; Liu, Mei; Carulli, John P.; Sun, Chao] Biogen Idec Inc, Genet & Gen, Cambridge, MA USA. [Dobrowolski, Steven F.] Univ Pittsburgh, Med Ctr, Dept Pathol, Pittsburgh, PA USA. RP Vogt, RF (reprint author), Ctr Dis Control & Prevent, Div Sci Lab, Mailstop F19,4770 Buford Highway, Atlanta, GA 30341 USA. EM rvogt@cdc.gov FU CDC Foundation; Biogen Idec FX CDC Foundation through an agreement with Biogen-Idec; G.K. Yazdanpanah, Biogen Idec through the CDC Foundation. NR 27 TC 7 Z9 7 U1 1 U2 6 PU AMER ASSOC CLINICAL CHEMISTRY PI WASHINGTON PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA SN 0009-9147 EI 1530-8561 J9 CLIN CHEM JI Clin. Chem. PD FEB PY 2015 VL 61 IS 2 BP 412 EP 419 DI 10.1373/clinchem.2014.231019 PG 8 WC Medical Laboratory Technology SC Medical Laboratory Technology GA CE8ZY UT WOS:000352134200016 PM 25502182 ER PT J AU Bender, JB Barlam, TF Glore, RP Gumley, N Grayzel, SE Hoang, C Murphy, MJ Papich, MG Sykes, JE Watts, JL Whichard, JM AF Bender, Jeff B. Barlam, Tamar F. Glore, Reilly P. Gumley, Nigel Grayzel, Sharon E. Hoang, Christine Murphy, Michael J. Papich, Mark G. Sykes, Jane E. Watts, Jeffrey L. Whichard, Jean M. CA AVMA Task Force Antimicrobial Stew TI Antimicrobial stewardship in companion animal practice SO JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION LA English DT Editorial Material ID INFECTIOUS-DISEASES SOCIETY; HEALTH-CARE EPIDEMIOLOGY; THERAPY; GUIDELINES; HOSPITALS; PROGRAM; AMERICA C1 [Bender, Jeff B.] Univ Minnesota, Coll Vet Med, Dept Vet Populat Med, St Paul, MN 55108 USA. [Barlam, Tamar F.] Boston Med Ctr, Infect Dis Sect, Boston, MA 02118 USA. [Glore, Reilly P.] Brady Vet Hosp, Montesano, WA 98563 USA. [Gumley, Nigel] Canadian Vet Med Assoc, Ottawa, ON K1R 7K1, Canada. [Grayzel, Sharon E.] Columbia Vet Ctr, Vancouver, WA 98665 USA. [Hoang, Christine] AVMA, Schaumburg, IL 60173 USA. [Murphy, Michael J.] US FDA, Ctr Vet Med, Rockville, MD 20855 USA. [Papich, Mark G.] N Carolina State Univ, Coll Vet Med, Dept Mol Biomed Sci, Raleigh, NC 27607 USA. [Sykes, Jane E.] Univ Calif Davis, Sch Vet Med, Dept Med & Epidemiol, Davis, CA 95616 USA. [Watts, Jeffrey L.] Zoetis, Antiinfect Res VMRD, Kalamazoo, MI 49009 USA. [Whichard, Jean M.] CDC, Atlanta, GA 30329 USA. RP Bender, JB (reprint author), Univ Minnesota, Coll Vet Med, Dept Vet Populat Med, St Paul, MN 55108 USA. EM Bende002@umn.edu NR 14 TC 1 Z9 1 U1 0 U2 2 PU AMER VETERINARY MEDICAL ASSOC PI SCHAUMBURG PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA SN 0003-1488 EI 1943-569X J9 JAVMA-J AM VET MED A JI JAVMA-J. Am. Vet. Med. Assoc. PD FEB 1 PY 2015 VL 246 IS 3 BP 287 EP 288 PG 2 WC Veterinary Sciences SC Veterinary Sciences GA CE8QA UT WOS:000352107400013 ER PT J AU Panicker, G Rajbhandari, I Gurbaxani, BM Querec, TD Unger, ER AF Panicker, G. Rajbhandari, I. Gurbaxani, B. M. Querec, T. D. Unger, E. R. TI Development and evaluation of multiplexed immunoassay for detection of antibodies to HPV vaccine types SO JOURNAL OF IMMUNOLOGICAL METHODS LA English DT Article DE HPV antibodies; Serology; ELISA; Multiplex; Meso Scale Discovery ID NEUTRALIZING EPITOPES; SERUM-ALBUMIN; PAPILLOMAVIRUS; TRIALS; ASSAYS; IMMUNOGENICITY; MODEL AB Reliable antibody based-assays are needed to evaluate the immunogenicity of current vaccines, impact of altered dosing schemes or of new vaccine formulations. An ideal assay platform would allow multiplex type-specific detection with minimal sample requirement. We used the Meso Scale Discovery (MSD) electrochemiluminescence based detection platform to develop a multiplex direct virus-like particle (VLP) ELISA to detect antibodies to HPV 6, 11, 16, and 18 with a protocol developed for detection using the SI 6000 imager (M4ELISA). MSD prepared the plates in the 7-spot/well format, using the purified VLPs (4 spots) and PBS + BSA pH 7.4 (3 blank spots). Three-point titrations and the parallel line method were used to calculate antibody levels. Dynamic range, precision, and stability of pre-printed plates were determined using a panel of previously characterized sera. Cut-off values using children's sera were established using 99% RLU limits based on the 4-parameter Johnson Su best fit curve. Results of the M4ELISA were compared to competitive Luminex Immunoassay (cLIA) on n = 4454 sera from a predominantly unvaccinated cohort . Using a VLP coating concentration of 80 mu g/ml with BSA provided the most robust RLU signal for all types. The dynamic range of the assay was about 1000 fold, with assay variability under 25% for each of the four vaccine types. Long-term stability of the plates extended to about 7 months from the time plates was received in the laboratory after printing. There was moderate agreement (k = 0.38-0.54) between M4ELISA and cLIA, with antibody detection for each of the 4 types more frequent with M4ELISA. Quantitative analysis however showed a good correlation between concordant samples by both assays (rho >= 0.6). The MSD platform shows promise for simultaneous quantitation of the antibody responses to four HPV vaccine types in a high-throughput manner. Published by Elsevier B.V. C1 [Panicker, G.; Rajbhandari, I.; Gurbaxani, B. M.; Querec, T. D.; Unger, E. R.] Ctr Dis Control & Prevent, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30329 USA. RP Panicker, G (reprint author), Ctr Dis Control & Prevent, Chron Viral Dis Branch, 1600 Clifton Rd MS G-41, Atlanta, GA 30329 USA. FU Intramural CDC HHS [CC999999] NR 21 TC 5 Z9 5 U1 1 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1759 EI 1872-7905 J9 J IMMUNOL METHODS JI J. Immunol. Methods PD FEB PY 2015 VL 417 BP 107 EP 114 DI 10.1016/j.jim.2014.12.013 PG 8 WC Biochemical Research Methods; Immunology SC Biochemistry & Molecular Biology; Immunology GA CE7UE UT WOS:000352046500012 PM 25554636 ER PT J AU Aspinall, EJ Doyle, JS Corson, S Hellard, ME Hunt, D Goldberg, D Nguyen, T Falck-Ytter, Y Morgan, RL Smith, B Stoove, M Wiktor, SZ Hutchinson, S AF Aspinall, Esther Jane Doyle, Joseph Samuel Corson, Stephen Hellard, Margaret Elena Hunt, David Goldberg, David Nguyen, Tim Falck-Ytter, Yngve Morgan, Rebecca Lynn Smith, Bryce Stoove, Mark Wiktor, Stefan Zbyszko Hutchinson, Sharon TI Targeted hepatitis C antibody testing interventions: a systematic review and meta-analysis SO EUROPEAN JOURNAL OF EPIDEMIOLOGY LA English DT Review DE Hepatitis C; Testing; Systematic review; Meta-analysis ID INJECTING DRUG-USERS; RANDOMIZED CONTROLLED-TRIAL; GENERAL-PRACTICE; VIRUS-INFECTION; RISK-FACTORS; VIRAL-HEPATITIS; COST-EFFECTIVENESS; CHARENTES REGION; CARE; MANAGEMENT AB Testing for hepatitis C virus (HCV) infection may reduce the risk of liver-related morbidity, by facilitating earlier access to treatment and care. This review investigated the effectiveness of targeted testing interventions on HCV case detection, treatment uptake, and prevention of liver-related morbidity. A literature search identified studies published up to 2013 that compared a targeted HCV testing intervention (targeting individuals or groups at increased risk of HCV) with no targeted intervention, and results were synthesised using meta-analysis. Exposure to a targeted testing intervention, compared to no targeted intervention, was associated with increased cases detected [number of studies (n) = 14; pooled relative risk (RR) 1.7, 95 % CI 1.3, 2.2] and patients commencing therapy (n = 4; RR 3.3, 95 % CI 1.1, 10.0). Practitioner-based interventions increased test uptake and cases detected (n = 12; RR 3.5, 95 % CI 2.5, 4.8; and n = 10; RR2.2, 95 % CI 1.4, 3.5, respectively), whereas media/ information-based interventions were less effective (n = 4; RR 1.5, 95 % CI 0.7, 3.0; and n = 4; RR 1.3, 95 % CI 1.0, 1.6, respectively). This meta-analysis provides for the first time a quantitative assessment of targeted HCV testing interventions, demonstrating that these strategies were effective in diagnosing cases and increasing treatment uptake. Strategies involving practitioner-based interventions yielded the most favourable outcomes. It is recommended that testing should be targeted at and offered to individuals who are part of a population with high HCV prevalence, or who have a history of HCV risk behaviour. C1 [Aspinall, Esther Jane; Hutchinson, Sharon] Glasgow Caledonian Univ, Sch Hlth & Life Sci, Glasgow G4 0BA, Lanark, Scotland. [Aspinall, Esther Jane; Goldberg, David; Hutchinson, Sharon] Hlth Protect Scotland, Glasgow G2 6QE, Lanark, Scotland. [Doyle, Joseph Samuel; Hellard, Margaret Elena; Hunt, David; Stoove, Mark] Burnet Inst, Melbourne, Vic 3004, Australia. [Doyle, Joseph Samuel; Hellard, Margaret Elena] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic 3800, Australia. [Doyle, Joseph Samuel; Hellard, Margaret Elena] Alfred Hlth, Dept Infect Dis, Melbourne, Vic 3181, Australia. [Corson, Stephen] Univ Strathclyde, Dept Math & Stat, Glasgow G1 1XQ, Lanark, Scotland. [Nguyen, Tim; Wiktor, Stefan Zbyszko] WHO, Global Hepatitis Programme, CH-1211 Geneva 27, Switzerland. [Falck-Ytter, Yngve] Case Western Reserve Univ, Case & VA Med Ctr, Cleveland, OH 44106 USA. [Morgan, Rebecca Lynn; Smith, Bryce] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Aspinall, EJ (reprint author), Glasgow Caledonian Univ, Sch Hlth & Life Sci, Glasgow G4 0BA, Lanark, Scotland. EM Esther.Aspinall@nhs.net FU World Health Organization Global Hepatitis Programme; NHMRC; Victorian Operational Infrastructure Support Program FX We would like to thank Ms. Beth Cullen, Prof. Walter Cullen, Dr. Charles Helsper, Prof. Matthew Hickman, Mr. Hamish Innes, Dr. Cameron Lacey, Dr. Heather Lewis, and Mr. Allan McLeod for providing additional data to inform this review. We would like to acknowledge the World Health Organization Global Hepatitis Programme for funding this review. Dr. Joseph Doyle receives a NHMRC research scholarship and Prof. Margaret Hellard receives a NHMRC senior research fellowship. The Burnet Institute receives funding from the Victorian Operational Infrastructure Support Program. NR 41 TC 3 Z9 3 U1 1 U2 3 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0393-2990 EI 1573-7284 J9 EUR J EPIDEMIOL JI Eur. J. Epidemiol. PD FEB PY 2015 VL 30 IS 2 BP 115 EP 129 DI 10.1007/s10654-014-9958-4 PG 15 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CE1XP UT WOS:000351606500004 PM 25385677 ER PT J AU Nass, SJ Beaupin, LK Demark-Wahnefried, W Fasciano, K Ganz, PA Hayes-Lattin, B Hudson, MM Nevidjon, B Oeffinger, KC Rechis, R Richardson, LC Seibel, NL Smith, AW AF Nass, Sharyl J. Beaupin, Lynda K. Demark-Wahnefried, Wendy Fasciano, Karen Ganz, Patricia A. Hayes-Lattin, Brandon Hudson, Melissa M. Nevidjon, Brenda Oeffinger, Kevin C. Rechis, Ruth Richardson, Lisa C. Seibel, Nita L. Smith, Ashley W. TI Identifying and Addressing theNeeds of Adolescents and Young Adults With Cancer: Summary of an Institute of Medicine Workshop SO ONCOLOGIST LA English DT Article DE Adolescent; Young adult; Cancer survivorship; Psychosocial aspects; Fertility preservation; Adverse effects ID LONG-TERM SURVIVORS; ACUTE LYMPHOBLASTIC-LEUKEMIA; HEALTH-INSURANCE COVERAGE; CAUSE-SPECIFIC MORTALITY; CHILDHOOD-CANCER; BREAST-CANCER; FERTILITY PRESERVATION; HODGKIN LYMPHOMA; PALLIATIVE CARE; PHYSICAL-ACTIVITY AB Cancer is the leading disease-related cause of death in adolescents and young adults (AYAs). This population faces many short-and long-term health and psychosocial consequences of cancer diagnosis and treatment, but many programs for cancer treatment, survivorship care, and psychosocial support do not focus on the specific needs of AYA cancer patients. Recognizing this health care disparity, the National Cancer Policy Forum of the Institute of Medicine convened a public workshop to examine the needs of AYA patients with cancer. Workshop participants identified many gaps and challenges in the care of AYA cancer patients and discussed potential strategies to address these needs. Suggestions included ways to improve access to care for AYAs, to deliver cancer care that better meets the medical and psychosocial needs of AYAs, to develop educational programs for providers who care for AYA cancer survivors, and to enhance the evidence base for AYAs with cancer by facilitating participation in research. C1 [Nass, Sharyl J.] Inst Med, Washington, DC 20001 USA. [Beaupin, Lynda K.] Roswell Pk Canc Inst, Buffalo, NY 14263 USA. [Demark-Wahnefried, Wendy] Univ Alabama Birmingham, Birmingham Comprehens Canc Ctr, Birmingham, AL USA. [Fasciano, Karen] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Ganz, Patricia A.] Univ Calif Los Angeles, Sch Med & Publ Hlth, Los Angeles, CA USA. [Hayes-Lattin, Brandon] Oregon Hlth & Sci Univ, Knight Canc Inst, Portland, OR 97201 USA. [Hudson, Melissa M.] St Jude Childrens Res Hosp, Memphis, TN 38105 USA. [Nevidjon, Brenda] Oncol Nursing Soc, Pittsburgh, PA USA. [Oeffinger, Kevin C.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. [Rechis, Ruth] LIVESTRONG Fdn, Austin, TX USA. [Richardson, Lisa C.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Seibel, Nita L.; Smith, Ashley W.] Natl Canc Inst, Bethesda, MD USA. RP Nass, SJ (reprint author), Inst Med, Natl Canc Policy Forum, 500 Fifth St, Washington, DC 20001 USA. EM snass@nas.edu FU LIVESTRONG Foundation; Young Adult Cancer Alliance; IOM's National Cancer Policy Forum FX The responsibility for the content of this article rests with the authors and does not necessarily represent the views of the Institute of Medicine, its committees, its sponsors, or its convening activities and does not represent the official position of the Centers for Disease Control and Prevention or that of the National Cancer Institute. We thank the LIVESTRONG Foundation for generously cosponsoring the IOM workshop and Critical Mass: The Young Adult Cancer Alliance for supporting the workshop. The activities of the IOM's National Cancer Policy Forum are supported by its sponsoring members, which currently include the Centers for Disease Control and Prevention, the National Cancer Institute, the Association of American Cancer Institutes, the American Association for Cancer Research, the American Cancer Society, the American Society of Clinical Oncology, the American Society of Hematology, the American Society for Radiation Oncology, AstraZeneca, Bristol-Myers Squibb, C-Change, the Cancer Support Community, the CEO Roundtable on Cancer, EMD Serono, Helsinn Group, the LIVESTRONG Foundation, the National Comprehensive Cancer Network, Novartis Oncology, the Oncology Nursing Society, and Sanofi Oncology. We thank the speakers and participants for their contributions to the workshop. We also thank Sarah Bender and Sara Tharakan for assistance with manuscript preparation. NR 89 TC 22 Z9 22 U1 2 U2 10 PU ALPHAMED PRESS PI DURHAM PA 318 BLACKWELL ST, STE 260, DURHAM, NC 27701-2884 USA SN 1083-7159 EI 1549-490X J9 ONCOLOGIST JI Oncologist PD FEB PY 2015 VL 20 IS 2 BP 186 EP 195 DI 10.1634/theoncologist.2014-0265 PG 10 WC Oncology SC Oncology GA CE5ZR UT WOS:000351915500015 PM 25568146 ER PT J AU Singh, N Bharti, PK Singh, MP Singh, R Yeboah-Antwi, K Desai, M Udhayakumar, V Muniyandi, M Hamer, DH Wylie, BJ AF Singh, Neeru Bharti, Praveen K. Singh, Mrigendra P. Singh, Rajshree Yeboah-Antwi, Kojo Desai, Meghna Udhayakumar, Venkatachalam Muniyandi, Malaisamy Hamer, Davidson H. Wylie, Blair J. TI What is the burden of submicroscopic malaria in pregnancy in central India? SO PATHOGENS AND GLOBAL HEALTH LA English DT Article DE Malaria; Pregnancy; Subpatent infection; Submicroscopic infection; Plasmodium falciparum; Anemia; India; Polymerase chain reaction ID PLASMODIUM-FALCIPARUM INFECTIONS; POLYMERASE-CHAIN-REACTION; LOW-BIRTH-WEIGHT; PLACENTAL MALARIA; DIAGNOSIS; WOMEN; EPIDEMIOLOGY; MICROSCOPY; SUDAN; GHANA AB Background: Conventional microscopy underestimates the burden of malarial infection when compared with molecular diagnosis using polymerase chain reaction (PCR)-based methods. Lower density parasitemias serve as a reservoir for infection. We evaluated the prevalence of submicroscopic infections in an area of unstable malarial transmission in India and determined whether these infections negatively impacted maternal or fetal outcomes. Methods: This cross-sectional study (2007-2008) was undertaken in two districts of Chhattisgarh, recruiting women from both antenatal clinics (ANCs) and delivery units (DUs). For ANC/DU subjects, peripheral/placental blood, respectively, was obtained for conventional microscopy and collected onto filter paper for PCR analysis. Results: There were 3425 pregnant women, including 2477 ANC subjects and 948 DU subjects who had both microscopic and PCR samples available. Polymerase chain reaction detected significantly more Plasmodium infections than traditional light microscopy both from peripheral (3.4 vs 1.2%; OR 2.9, 95% confidence intervals (CIs) 1.9-4.5) and placental (4.2 vs 1.7%; OR 2.5, 95% CIs 1.4-4.8) blood samples. Submicroscopic infections were not associated with anemia or severe maternal anemia among ANC or DU participants and were not associated with low birth weight (LBW) among DU participants. In contrast, microscopically detected infections were associated with severe anemia and LBW. Conclusions: In this area of unstable malarial transmission from India, submicroscopic infections did not identify a set of pregnant women at increased risk for anemia or LBW. Until PCR techniques become much less expensive and available as a point of care test for the field setting, its use will be limited for malarial detection. C1 [Singh, Neeru; Bharti, Praveen K.; Singh, Rajshree; Muniyandi, Malaisamy] Reg Med Res Ctr Tribals, Jabalpur, Madhya Pradesh, India. [Singh, Mrigendra P.] Natl Inst Malaria Res Field Stn, Jabalpur, Madhya Pradesh, India. [Yeboah-Antwi, Kojo; Hamer, Davidson H.] Boston Univ, Ctr Global Hlth & Dev, Boston, MA 02215 USA. [Yeboah-Antwi, Kojo; Hamer, Davidson H.] Boston Univ, Sch Publ Hlth, Dept Global Hlth, Boston, MA 02215 USA. [Desai, Meghna; Udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA USA. [Hamer, Davidson H.] Boston Univ, Sch Med, Dept Med, Infect Dis Sect, Boston, MA 02215 USA. [Wylie, Blair J.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Maternal Fetal Med,Dept Obstet & Gynecol, Boston, MA USA. RP Singh, N (reprint author), Reg Med Res Ctr Tribals, Jabalpur, Madhya Pradesh, India. EM neerusingh@gmail.com FU Indo-U.S. Collaborative Network; ICMR; National Institute of Child Health and Development [1 R03 HD52167-01]; National Institutes of Health (NIH) [K23 ES021471] FX This work was supported by the Indo-U.S. Collaborative Network with funding from the ICMR and the National Institute of Child Health and Development (1 R03 HD52167-01). The contents of this manuscript are solely the responsibility of the authors and do not necessarily represent the official views of the ICMR or the National Institute of Health. BJW was supported by the National Institutes of Health (NIH K23 ES021471). NR 36 TC 1 Z9 1 U1 1 U2 7 PU MANEY PUBLISHING PI LEEDS PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND SN 2047-7724 EI 2047-7732 J9 PATHOG GLOB HEALTH JI Pathog. Glob. Health PD FEB PY 2015 VL 109 IS 1 BP 30 EP 38 DI 10.1179/2047773215Y.0000000002 PG 9 WC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine SC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine GA CD5JD UT WOS:000351122900007 PM 25627878 ER PT J AU Singh, E Underwood, JM Nattey, C Babb, C Sengayi, M Kellett, P AF Singh, E. Underwood, J. M. Nattey, C. Babb, C. Sengayi, M. Kellett, P. TI South African National Cancer Registry: Effect of withheld data from private health systems on cancer incidence estimates SO SAMJ SOUTH AFRICAN MEDICAL JOURNAL LA English DT Article ID COLLABORATIVE REANALYSIS; INDIVIDUAL DATA; CERVICAL-CANCER; BLACK-POPULATION; WOMEN; CARCINOMA; SPECTRUM AB Background. The National Cancer Registry (NCR) was established as a pathology-based cancer reporting system. From 2005 to 2007, private health laboratories withheld cancer reports owing to concerns regarding voluntary sharing of patient data. Objectives. To estimate the impact of under-reported cancer data from private health laboratories. Methods. A linear regression analysis was conducted to project expected cancer cases for 2005 - 2007. Differences between actual and projected figures were calculated to estimate percentage under-reporting. Results. The projected NCR case total varied from 53 407 (3.8% net increase from actual cases reported) in 2005 to 54 823 (3.7% net increase) in 2007. The projected number of reported cases from private laboratories in 2005 Was 26 359 (19.7% net increase from actual cases reported), 27 012 (18.8% net increase) in 2006 and 27 666 (28.4% net increase) in 2007. Conclusion. While private healthcare reporting decreased by 28% from 2005 to 2007, this represented a minimal impact on overall cancer reporting (net decrease of <4%). C1 [Singh, E.; Babb, C.; Sengayi, M.; Kellett, P.] Natl Hlth Lab Serv, Natl Canc Registry, Canc Epidemiol Res Grp, Johannesburg, South Africa. [Singh, E.; Nattey, C.] Univ Witwatersrand, Fac Hlth Sci, Johannesburg, South Africa. [Underwood, J. M.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Nattey, C.] Natl Hlth Lab Serv, Natl Inst Occupat Hlth, Johannesburg, South Africa. [Sengayi, M.] Univ Bern, Grad Sch Cellular & Biomed Sci, CH-3012 Bern, Switzerland. RP Singh, E (reprint author), Natl Hlth Lab Serv, Natl Canc Registry, Canc Epidemiol Res Grp, Johannesburg, South Africa. EM elvira.singh@nioh.nhls.ac.za OI Babb, Chantal/0000-0003-1334-1819; /0000-0002-1955-923X FU Intramural CDC HHS [CC999999] NR 27 TC 6 Z9 7 U1 1 U2 1 PU SA MEDICAL ASSOC PI PRETORIA PA BLOCK F CASTLE WALK CORPORATE PARK, NOSSOB STREET, ERASMUSKLOOF EXT3, PRETORIA, 0002, SOUTH AFRICA SN 0256-9574 EI 2078-5135 J9 SAMJ S AFR MED J JI SAMJ S. Afr. Med. J. PD FEB PY 2015 VL 105 IS 2 BP 107 EP 109 DI 10.7196/SAMJ.8858 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA CD8HZ UT WOS:000351337100016 PM 26242527 ER PT J AU Abdul-Quader, AS Gouws-Williams, E Tlou, S Wright-De Aguero, L Needle, R AF Abdul-Quader, Abu S. Gouws-Williams, Eleanor Tlou, Sheila Wright-De Agueero, Linda Needle, Richard TI Key Populations in Sub-Saharan Africa: Population Size Estimates and High Risk Behaviors SO AIDS AND BEHAVIOR LA English DT Editorial Material C1 [Abdul-Quader, Abu S.; Wright-De Agueero, Linda; Needle, Richard] Ctr Dis Control & Prevent, Div Global HIV AIDS, Ctr Global Hlth, Atlanta, GA 30333 USA. [Gouws-Williams, Eleanor; Tlou, Sheila] UNAIDS Reg Support Team Eastern & Southern Africa, ZA-2157 Johannesburg, South Africa. RP Abdul-Quader, AS (reprint author), Ctr Dis Control & Prevent, Div Global HIV AIDS, Ctr Global Hlth, 1600 Clifton Rd,MS-E30, Atlanta, GA 30333 USA. EM afa3@cdc.gov; gouwse@unaids.org; tlous@unaids.org; lkw1@cdc.gov; RNeedle@cdc.gov NR 0 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1090-7165 EI 1573-3254 J9 AIDS BEHAV JI AIDS Behav. PD FEB PY 2015 VL 19 SU 1 BP S1 EP S2 DI 10.1007/s10461-014-0963-0 PG 2 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA CD1ZQ UT WOS:000350873600001 PM 25480597 ER PT J AU Baltazar, CS Horth, R Inguane, C Sathane, I Cesar, F Ricardo, H Botao, C Augusto, A Cooley, L Cummings, B Raymond, HF Young, PW AF Baltazar, Cynthia Sema Horth, Roberta Inguane, Celso Sathane, Isabel Cesar, Freide Ricardo, Helena Botao, Carlos Augusto, Angelo Cooley, Laura Cummings, Beverly Raymond, Henry F. Young, Peter W. TI HIV Prevalence and Risk Behaviors Among Mozambicans Working in South African Mines SO AIDS AND BEHAVIOR LA English DT Article DE Mineworkers; Mozambique; HIV; Prevalence; Risk behaviors; South African mines ID MALE CIRCUMCISION; MIGRATION; MEN; POPULATIONS; PREVENTION; IMPACT; TRIAL; KENYA AB Mineworkers are considered a population at risk for HIV due to risk behaviors associated with migratory work patterns. This was the first study in Mozambique to determine the prevalence of HIV and associated demographic and risk behaviors, and assess use and access to prevention and healthcare services among Mozambicans working in South African mines. Men who had worked in a South African mine in the past 12 months were recruited between February and May 2012 using time location sampling (TLS) at the Ressano Garcia border between Mozambique and South Africa. Demographic and behavioral data were collected through a standardized questionnaire, and HIV prevalence was estimated by testing dried blood spots (DBS) with two enzyme immunoassays. In total, 432 eligible mine workers were recruited. Mean age was 43 years. Most were married or cohabitating; among them, 12.6 % had two or more wives/marital partners in Mozambique. In the 12 months preceding the survey, 24.7 % had an occasional sexual partner, and 6.6 % had at least one partner who was a female sex worker. Only one in five (18.5 %) used a condom during last sex. HIV prevalence among mineworkers was 22.3 %, and 74.6 % of those who tested positive as part of the survey did not know their status. HIV prevalence was significantly higher (p = 0.018) among those that were uncircumcised (31.2 %) than those who were circumcised (18.5 %). Multiple partners (multiple spouses, cross-border relations, and multiple occasional partnerships), inconsistent condom use, and a high proportion of infected mineworkers who do not know their HIV status increases the risk of HIV transmission in this population. Combination strategies involving the promotion of condom use, HIV testing, and male circumcision should be strengthened among mineworkers. C1 [Baltazar, Cynthia Sema; Ricardo, Helena; Botao, Carlos; Augusto, Angelo] Natl Inst Hlth, Maputo, Mozambique. [Horth, Roberta; Raymond, Henry F.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Horth, Roberta; Inguane, Celso; Sathane, Isabel; Cesar, Freide] Int Training & Educ Ctr Hlth, Maputo, Mozambique. [Cooley, Laura] Ctr Dis Control & Prevent CDC, Div Global HIV AIDS, Atlanta, GA USA. [Cummings, Beverly; Young, Peter W.] Ctr Dis Control & Prevent CDC, Div Global HIV AIDS, Maputo, Mozambique. RP Baltazar, CS (reprint author), Natl Inst Hlth, POB 264, Maputo, Mozambique. EM cynthiasema@yahoo.com FU President's Emergency Plan for AIDS Relief (PEPFAR) through the U.S. Centers for Disease Control and Prevention (CDC) Mozambique Country Office [U2GPS001468] FX This paper used data from research supported by the President's Emergency Plan for AIDS Relief (PEPFAR) through the U.S. Centers for Disease Control and Prevention (CDC) Mozambique Country Office under the terms of Cooperative Agreement Number U2GPS001468. The views expressed in this article do not necessarily reflect the views of the U.S. Centers for Disease Control and Prevention or the U.S. Government. NR 23 TC 5 Z9 5 U1 0 U2 3 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1090-7165 EI 1573-3254 J9 AIDS BEHAV JI AIDS Behav. PD FEB PY 2015 VL 19 SU 1 BP S59 EP S67 DI 10.1007/s10461-014-0941-6 PG 9 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA CD1ZQ UT WOS:000350873600007 PM 25398418 ER PT J AU Matiko, E Khatib, A Khalid, F Welty, S Said, C Ali, A Othman, A Haji, S Kibona, M Kim, E Broz, D Dahoma, M AF Matiko, Eva Khatib, Ahmed Khalid, Farhat Welty, Susie Said, Christen Ali, Ameir Othman, Asha Haji, Shaaban Kibona, Mary Kim, Evelyn Broz, Dita Dahoma, Mohammed TI HIV Prevalence and Risk Behaviors Among People Who Inject drugs in Two Serial Cross-Sectional Respondent-Driven Sampling Surveys, Zanzibar 2007 and 2012 SO AIDS AND BEHAVIOR LA English DT Article DE HIV; Tanzania; Sexual behavior; Injection drug use; Respondent; driven sampling ID INTERNATIONAL SETTINGS; USERS; SURVEILLANCE; METHODOLOGY; INFECTION; TANZANIA AB People who inject drugs (PWID) are at higher risk of acquiring HIV due to risky injection and sexual practices. We measured HIV prevalence and behaviors related to acquisition and transmission risk at two time points (2007 and 2012) in Zanzibar, Tanzania. We conducted two rounds of behavioral and biological surveillance among PWID using respondent-driven sampling, recruiting 499 and 408 PWID, respectively. Through faceto- face interviews, we collected information on demographics as well as sexual and injection practices. We obtained blood samples for biological testing. We analyzed data using RDSAT and exported weights into STATA for multivariate analysis. HIV prevalence among sampled PWID in Zanzibar was 16.0 % in 2007 and 11.3 % in 2012; 73.2 % had injected drugs for 7 years or more in 2007, while in the 2012 sample this proportion was 36.9 %. In 2007, 53.6 % reported having shared a needle in the past month, while in the 2012 sample, 29.1 % reported having done so. While 13.3 % of PWID in 2007 reported having been tested for HIV infection and received results in the past year, this proportion was 38.0 % in 2012. Duration of injection drug use for 5 years or more was associated with higher odds of HIV infection in both samples. HIV prevalence and indicators of risk and preventive behaviors among PWID in Zanzibar were generally more favorable in 2012 compared to 2007-a period marked by the scale-up of prevention programs focusing on PWID. While encouraging, causal interpretation needs to be cautious and consider possible sample differences in these two cross-sectional surveys. HIV prevalence and related risk behaviors persist at levels warranting sustained and enhanced efforts of primary prevention and harm reduction. C1 [Matiko, Eva; Kibona, Mary] US Embassy, CDC Tanzania, Div Global HIV AIDS, US Ctr Dis Control & Prevent, Dar Es Salaam, Tanzania. [Khatib, Ahmed; Khalid, Farhat; Ali, Ameir; Othman, Asha; Haji, Shaaban] Minist Hlth, Zanzibar AIDS Control Program, Zanzibar, Tanzania. [Welty, Susie; Said, Christen] Univ Calif San Francisco, Global Hlth Sci, San Francisco, CA 94143 USA. [Kim, Evelyn; Broz, Dita] US Ctr Dis Control & Prevent, Div Global HIV AIDS, Atlanta, GA USA. [Dahoma, Mohammed] Minist Hlth, Directorate Prevent Serv & Hlth Educ, Zanzibar, Tanzania. RP Matiko, E (reprint author), US Embassy, CDC Tanzania, Div Global HIV AIDS, US Ctr Dis Control & Prevent, 686 Old Bagamoyo Rd,POB 9123, Dar Es Salaam, Tanzania. EM iyt9@cdc.gov; ahmedbenga@yahoo.com; farhat_jowhar@yahoo.com; swelty@psg.ucsf.edu; cmullen@psg.ucsf.edu; ameirali@yahoo.co.uk; ashaahmed26@yahoo.com; jechah3@yahoo.com; iys8@cdc.gov; gvh5@cdc.gov; iga4@cdc.gov; mjudahoma@yahoo.com FU President's Emergency Plan for AIDS Relief (PEPFAR) through the Centers for Disease Control and Prevention (CDC) [5UGPS002039-02] FX We thank the numerous members of the research design and data collection team as well as the men and women who participated in this study. This research has been supported by the President's Emergency Plan for AIDS Relief (PEPFAR) through the Centers for Disease Control and Prevention (CDC) under the terms of cooperative agreement 5UGPS002039-02. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the CDC. NR 22 TC 1 Z9 1 U1 0 U2 2 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1090-7165 EI 1573-3254 J9 AIDS BEHAV JI AIDS Behav. PD FEB PY 2015 VL 19 SU 1 BP S36 EP S45 DI 10.1007/s10461-014-0929-2 PG 10 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA CD1ZQ UT WOS:000350873600005 PM 25399032 ER PT J AU Quaye, S Raymond, HF Atuahene, K Amenyah, R Aberle-Grasse, J McFarland, W El-Adas, A AF Quaye, Silas Raymond, H. Fisher Atuahene, Kyeremeh Amenyah, Richard Aberle-Grasse, John McFarland, Willi El-Adas, Angela CA Ghana Men Study Grp TI Critique and Lessons Learned from using Multiple Methods to Estimate Population Size of Men who have Sex with Men in Ghana SO AIDS AND BEHAVIOR LA English DT Article DE Men who have sex with men; Africa; Population size estimates ID SUB-SAHARAN AFRICA; HIV-INFECTION; EPIDEMIOLOGY; REDUCTION; WORKERS; RISK AB Population size estimation of key populations at risk of HIV is essential to every national response. We implemented population size estimation of men who have sex with men (MSM) in Ghana using a three-stage approach within the 2011 Ghana Men's Study: during the study's formative assessment, the larger integrated bio-behavioral surveillance (IBBS) survey; and during the stakeholder meeting. We used six methods in combination within the three-stage approach (literature review, mapping with census, unique object multiplier, service multiplier, wisdom of the crowd, and modified Delphi) to generate size estimates from 16 locations (4 IBBS survey sites and 12 other locations) and used the estimates from the 16 sites to extrapolate the total MSM population size of Ghana. We estimated the number of MSM in Ghana to be 30,579 with a plausible range of 21,645-34,470. The overall estimate suggests that the prevalence of MSM in Ghana is 0.48 % of the adult male population. Lessons learned are shared to inform and improve applications of the methods in future studies. C1 [Quaye, Silas] Ctr Dis Control & Prevent, Div Global HIV AIDS, Ctr Global Hlth, Cantonments, Accra, Ghana. [Raymond, H. Fisher; McFarland, Willi] Univ Calif San Francisco, Global Hlth Sci Prevent & Publ Hlth Grp, San Francisco, CA 94143 USA. [Raymond, H. Fisher; McFarland, Willi] San Francisco Dept Publ Hlth, San Francisco, CA USA. [Atuahene, Kyeremeh; El-Adas, Angela] Ghana AIDS Commiss, Accra, Ghana. [Amenyah, Richard] UNAIDS Tech Support Facil, Parktown, South Africa. [Aberle-Grasse, John] Ctr Dis Control & Prevent, Div Global HIV AIDS, Ctr Global Hlth, Atlanta, GA USA. RP Quaye, S (reprint author), Ctr Dis Control & Prevent, Div Global HIV AIDS, Ctr Global Hlth, 24 Fourth Circular Rd, Cantonments, Accra, Ghana. EM wej7@cdc.gov FU President's Emergency Plan for AIDS Relief (PEPFAR) through the U.S. Centers for Disease Control and Prevention (CDC) Ghana Country Office [5U2GPS001469-03] FX This research has been supported by the President's Emergency Plan for AIDS Relief (PEPFAR) through the U.S. Centers for Disease Control and Prevention (CDC) Ghana Country Office under the terms of Cooperative Agreement Number 5U2GPS001469-03. The authors would like to thank Dr. Fazle Khan, Dr. Celia Woodfill and all reviewers for helpful comments on the manuscript. The views expressed in this manuscript do not necessarily reflect the official views of the U.S. Centers for Disease Control and Prevention. NR 21 TC 7 Z9 7 U1 0 U2 0 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1090-7165 EI 1573-3254 J9 AIDS BEHAV JI AIDS Behav. PD FEB PY 2015 VL 19 SU 1 BP S16 EP S23 DI 10.1007/s10461-014-0943-4 PG 8 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA CD1ZQ UT WOS:000350873600003 PM 25704987 ER PT J AU Schwitters, A Swaminathan, M Serwadda, D Muyonga, M Shiraishi, RW Benech, I Mital, S Bosa, R Lubwama, G Hladik, W AF Schwitters, Amee Swaminathan, Mahesh Serwadda, David Muyonga, Michael Shiraishi, Ray W. Benech, Irene Mital, Sasha Bosa, Rose Lubwama, George Hladik, Wolfgang TI Prevalence of Rape and Client-Initiated Gender-Based Violence Among Female Sex Workers: Kampala, Uganda, 2012 SO AIDS AND BEHAVIOR LA English DT Article DE Sex workers; Violence; Uganda ID INTIMATE PARTNER VIOLENCE; SEXUALLY-TRANSMITTED INFECTIONS; CONDOM USE PROGRAM; HEALTH CONSEQUENCES; SOUTH-AFRICA; WOMEN; RISK; HIV; BEHAVIOR; IMPACT AB We utilized data from the 2012 Crane Survey in Kampala, Uganda to estimate prevalence of rape among female sex workers (FSWs) and to identify risk factors for and prevalence of client-initiated gender-based violence (GBV) among FSWs. Participants were recruited using respondent-driven sampling. Analyses were weighted using RDSAT-generated individualized weights for each of the five dependent GBV outcomes. Analyses were conducted utilizing SAS 9.3. Among 1,467 FSWs who were interviewed, 82 % (95 % CI: 79-84) experienced client-initiated GBV and 49 % (95 % CI: 47-53) had been raped at least once in their lifetime. GBV risk increased with increasing frequency of client demands for unprotected sex, length of time engaged in sex work, and FSW alcohol consumption. Risk decreased when sex with clients occurred at the FSW's or client's house or a hotel compared to when sex occurred in open spaces. Our findings demonstrate a high prevalence of GBV among FSWs. This research reinforces the urgent need for GBV prevention and response strategies to be integrated into FSW programming and the continuing need for GBV research among key populations. C1 [Schwitters, Amee] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Div Global HIV AIDS, Ctr Global Hlth, Atlanta, GA 30329 USA. [Schwitters, Amee; Swaminathan, Mahesh; Shiraishi, Ray W.; Benech, Irene; Mital, Sasha; Hladik, Wolfgang] Ctr Dis Control & Prevent, Div Global HIV AIDS, Ctr Global Hlth, Atlanta, GA 30329 USA. [Serwadda, David; Lubwama, George] Makerere Univ, Kampala, Uganda. [Muyonga, Michael] Minist Hlth, Kampala, Uganda. [Bosa, Rose] Ctr Dis Control & Prevent, Div Global HIV AIDS, Ctr Global Hlth, Entebbe, Uganda. RP Schwitters, A (reprint author), Ctr Dis Control & Prevent, Div Global HIV AIDS, Ctr Global Hlth, 1600 Clifton Rd NE,Mailstop E-30, Atlanta, GA 30329 USA. EM efn6@cdc.gov FU President's Emergency Plan for AIDS Relief (PEPFAR) through the Centers for Disease Control and Prevention (CDC) [U2GGH000466.02] FX This project has been supported by the President's Emergency Plan for AIDS Relief (PEPFAR) through the Centers for Disease Control and Prevention (CDC) under the terms of project number U2GGH000466.02. The authors thank the Crane Survey participants. NR 59 TC 12 Z9 12 U1 8 U2 11 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1090-7165 EI 1573-3254 J9 AIDS BEHAV JI AIDS Behav. PD FEB PY 2015 VL 19 SU 1 BP S68 EP S76 DI 10.1007/s10461-014-0957-y PG 9 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA CD1ZQ UT WOS:000350873600008 PM 25432876 ER PT J AU Tun, W Sheehy, M Broz, D Okal, J Muraguri, N Raymond, HF Musyoki, H Kim, AA Muthui, M Geibel, S AF Tun, Waimar Sheehy, Meredith Broz, Dita Okal, Jerry Muraguri, Nicholas Raymond, H. Fisher Musyoki, Helgar Kim, Andrea A. Muthui, Mercy Geibel, Scott TI HIV and STI Prevalence and Injection Behaviors Among People Who Inject Drugs in Nairobi: Results from a 2011 Bio-behavioral Study Using Respondent-Driven Sampling SO AIDS AND BEHAVIOR LA English DT Article DE HIV prevalence; STI prevalence; People who inject drugs; Kenya; Integrated biobehavioral; Surveillance survey; Respondent-driven sampling ID C VIRUS-INFECTION; DAR-ES-SALAAM; HEPATITIS-C; HUMAN IMMUNODEFICIENCY; SEXUAL TRANSMISSION; HIDDEN POPULATIONS; BENZODIAZEPINE USE; RISK BEHAVIORS; USERS; PREVENTION AB There is a dearth of evidence on injection drug use and associated HIV infections in Kenya. To generate population-based estimates of characteristics and HIV/STI prevalence among people who inject drugs (PWID) in Nairobi, a cross-sectional study was conducted with 269 PWID using respondent-driven sampling. PWID were predominantly male (92.5 %). An estimated 67.3 % engaged in at least one risky injection practice in a typical month. HIV prevalence was 18.7 % (95 % CI 12.3-26.7), while STI prevalence was lower [syphilis: 1.7 % (95 % CI 0.2-6.0); gonorrhea: 1.5 % (95 % CI 0.1-4.9); and Chlamydia: 4.2 % (95 % CI 1.2-7.8)]. HIV infection was associated with being female (aOR, 3.5; p = 0.048), having first injected drugs 5 or more years ago (aOR, 4.3; p = 0.002), and ever having practiced receptive syringe sharing (aOR, 6.2; p = 0.001). Comprehensive harm reduction programs tailored toward PWID and their sex partners must be fully implemented as part of Kenya's national HIV prevention strategy. C1 [Tun, Waimar; Geibel, Scott] Populat Council, HIV & AIDS Program, Washington, DC 20008 USA. [Sheehy, Meredith] Populat Council, New York, NY 10021 USA. [Broz, Dita] Ctr Dis Control & Prevent, HHS, Div Global HIV AIDS, Ctr Global Hlth, Atlanta, GA USA. [Broz, Dita] Ctr Global Hlth, Div Global HIV AIDS, Atlanta, GA USA. [Okal, Jerry] Populat Council, Nairobi, Kenya. [Muraguri, Nicholas; Musyoki, Helgar] Natl AIDS & STD Control Programme, Nairobi, Kenya. [Raymond, H. Fisher] San Francisco Dept Hlth, San Francisco, CA USA. [Kim, Andrea A.; Muthui, Mercy] Ctr Dis Control & Prevent, HHS, Div Global HIV AIDS, Ctr Global Hlth, Nairobi, Kenya. [Kim, Andrea A.; Muthui, Mercy] Ctr Global Hlth, Div Global HIV AIDS, Nairobi, Kenya. RP Tun, W (reprint author), Populat Council, HIV & AIDS Program, 4301 Connecticut Ave NW,Suite 280, Washington, DC 20008 USA. EM wtun@popcouncil.org FU President's Emergency Plan for AIDS Relief through The Centers for Disease Control and Prevention (CDC), through the Population Council [5U62PS224506] FX The authors wish to thank the National HIV and STI Control Programme (NASCOP), the National AIDS Control Council, the Nairobi Outreach Services Trust (NOSET), the United Nations Office of Drugs and Crime (UNODC), Liverpool VCT, the University of Nairobi Institute of Tropical and Infectious Diseases (UNITID) Laboratory, the Mombasa HIV/STD Research Laboratory, the University of Washington, and the participants for their respective supportive roles in the successful completion of this research. This study was funded by the President's Emergency Plan for AIDS Relief through The Centers for Disease Control and Prevention (CDC), through the Population Council's cooperative agreement of Award No. 5U62PS224506. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the CDC. NR 75 TC 2 Z9 2 U1 1 U2 1 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1090-7165 EI 1573-3254 J9 AIDS BEHAV JI AIDS Behav. PD FEB PY 2015 VL 19 SU 1 BP S24 EP S35 DI 10.1007/s10461-014-0936-3 PG 12 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA CD1ZQ UT WOS:000350873600004 PM 25398417 ER PT J AU Epson, EE Zheteyeva, YA Rainey, JJ Gao, HJ Shi, JR Uzicanin, A Miller, L AF Epson, Erin E. Zheteyeva, Yenlik A. Rainey, Jeanette J. Gao, Hongjiang Shi, Jianrong Uzicanin, Amra Miller, Lisa TI Evaluation of an Unplanned School Closure in a Colorado School District: Implications for Pandemic Influenza Preparedness SO DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS LA English DT Article DE pandemics; decision making; organizational; emergency preparedness; public health; health policy ID A H1N1; TRANSMISSION; HOUSEHOLDS; IMPACT AB Objective From January 29 through February 5, 2013, a school district outside metropolitan Denver, Colorado, was closed because of absenteeism related to influenza-like illness (ILI) among students and staff. We evaluated the consequences and acceptability of the closure among affected households. Methods We conducted a household survey regarding parent or guardian employment and income interruptions, alternative child care arrangements, interruption of noneducational school services, ILI symptoms, student re-congregation, and communication preferences during the closure. Results Of the 35 (31%) of 113 households surveyed, the majority (28 [80%]) reported that the closure was not challenging. Seven (20%) households reported challenges: 5 (14%) reported that 1 or more adults missed work, 3 (9%) reported lost pay, and 1 (3%) reported challenges because of missed subsidized school meals. The majority (22 [63%]) of households reported that a hypothetical 1-month closure would not represent a problem; 6 of 8 households that did anticipate challenges reported that all adults worked outside the home. The majority (58%) of students visited at least 1 outside venue during the closure. Conclusions A brief school closure did not pose a major problem for the majority of the affected households surveyed. School and public health officials should consider the needs of families in which all adults work outside the home when creating school closure contingency plans. (Disaster Med Public Health Preparedness. 2015;9:4-8) C1 [Epson, Erin E.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. [Zheteyeva, Yenlik A.; Rainey, Jeanette J.; Gao, Hongjiang; Shi, Jianrong; Uzicanin, Amra] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Community Intervent Infect Control Unit, Atlanta, GA USA. [Epson, Erin E.; Miller, Lisa] Colorado Dept Publ Hlth & Environm, Denver, CO USA. RP Zheteyeva, YA (reprint author), CDC, DGMQ, 1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM igg0@cdc.gov NR 10 TC 2 Z9 2 U1 0 U2 5 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1935-7893 EI 1938-744X J9 DISASTER MED PUBLIC JI Dis. Med. Public Health Prep. PD FEB PY 2015 VL 9 IS 1 BP 4 EP 8 DI 10.1017/dmp.2015.3 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CC9DR UT WOS:000350668600002 PM 25739043 ER PT J AU Pauvolid-Correa, A Juliano, RS Campos, Z Velez, J Nogueira, RMR Komar, N AF Pauvolid-Correa, Alex Juliano, Raquel Soares Campos, Zilca Velez, Jason Ribeiro Nogueira, Rita Maria Komar, Nicholas TI Neutralising antibodies for Mayaro virus in Pantanal, Brazil SO MEMORIAS DO INSTITUTO OSWALDO CRUZ LA English DT Article DE Mayaro virus; Venezuelan equine encephalitis virus; equids; caimans; sheep; Pantanal ID EASTERN EQUINE ENCEPHALITIS; WEST-NILE-VIRUS; MATO-GROSSO; HORSES; ENCEPHALOMYELITIS; STATE; ARBOVIRUSES; CIRCULATION; ALPHAVIRUS; VENEZUELA AB The Pantanal hosts diverse wildlife species and therefore is a hotspot for arbovirus studies in South America. A serosurvey for Mayaro virus (MAYV), eastern (EEEV), western (WEEV) and Venezuelan (VEEV) equine encephalitis viruses was conducted with 237 sheep, 87 free-ranging caimans and 748 equids, including 37 collected from a ranch where a neurologic disorder outbreak had been recently reported. Sera were tested for specific viral antibodies using plaque-reduction neutralisation test. From a total of 748 equids, of which 264 were immunised with vaccine composed of EEEV and WEEV and 484 had no history of immunisation, 10 (1.3%) were seropositive for MAYV and two (0.3%) for VEEV using criteria of a >= 4-fold antibody titre difference. Among the 484 equids without history of immunisation, 48 (9.9%) were seropositive for EEEV and four (0.8%) for WEEV using the same criteria. Among the sheep, five were sero-positive for equine encephalitis alphaviruses, with one (0.4%) for EEEV, one (0.4%) for WEEV and three (1.3%) for VEEV. Regarding free-ranging caimans, one (1.1%) and three (3.4%), respectively, had low titres for neutralising antibodies to VEEV and undetermined alphaviruses. The neurological disorder outbreak could not be linked to the alphaviruses tested. Our findings represent strong evidence that MAYV and all equine encephalitis alphaviruses circulated in the Pantanal. C1 [Pauvolid-Correa, Alex; Ribeiro Nogueira, Rita Maria] Inst Oswaldo Cruz Fiocruz, Lab Flavivirus, Rio De Janeiro, RJ, Brazil. [Pauvolid-Correa, Alex; Velez, Jason; Komar, Nicholas] Ctr Dis Control & Prevent, Arbovirus Dis Branch, Ft Collins, CO USA. [Juliano, Raquel Soares; Campos, Zilca] Minist Agr Pecuaria & Abastecimento, Embrapa Pantanal, Corumba, MS, Brazil. RP Pauvolid-Correa, A (reprint author), Inst Oswaldo Cruz Fiocruz, Lab Flavivirus, Rio De Janeiro, RJ, Brazil. EM pauvolid@ioc.fiocruz.br NR 57 TC 3 Z9 3 U1 0 U2 3 PU FUNDACO OSWALDO CRUZ PI RIO DE JANEIRO, RJ PA AV BRASIL 4365, 21045-900 RIO DE JANEIRO, RJ, BRAZIL SN 0074-0276 EI 1678-8060 J9 MEM I OSWALDO CRUZ JI Mem. Inst. Oswaldo Cruz PD FEB PY 2015 VL 110 IS 1 BP 125 EP 133 DI 10.1590/0074-02760140383 PG 9 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA CC9OB UT WOS:000350699000012 PM 25742272 ER PT J AU Jeffries, WL Townsend, ES Gelaude, DJ Torrone, EA Gasiorowicz, M Bertolli, J AF Jeffries, William L. Townsend, Ebony Symone Gelaude, Deborah J. Torrone, Elizabeth A. Gasiorowicz, Mari Bertolli, Jeanne TI HIV STIGMA EXPERIENCED BY YOUNG MEN WHO HAVE SEX WITH MEN (MSM) LIVING WITH HIV INFECTION SO AIDS EDUCATION AND PREVENTION LA English DT Article ID AFRICAN-AMERICAN; POSITIVE MEN; BLACK-MEN; HEALTH; DISCRIMINATION; HIV/AIDS; RISK; DISCLOSURE; ADHERENCE AB Stigma can compromise the health of persons living with HIV. Although HIV is increasingly affecting young men who have sex with men (MSM), little is known about their experiences with HIV stigma. We used narrative data to examine HIV stigma experienced by young MSM living with HIV. Data came from 28 qualitative interviews with young MSM. We used inductive content analysis to identify themes across these interviews. Participants commonly discussed negative perceptions and treatment of persons living with HIV. Stigma could result in nondisclosure of HIV status, internalized stigma, and avoidance of HIV-related things. Some men discussed strategies that might combat stigma. Findings suggest that HIV stigma might challenge young MSM's health by undermining health-conducive resources (e.g., social support) and contributing to HIV vulnerability. Interventions that counteract HIV stigma may help to create environments that promote well-being among young MSM living with HIV. C1 [Jeffries, William L.; Townsend, Ebony Symone; Gelaude, Deborah J.; Bertolli, Jeanne] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Torrone, Elizabeth A.] Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Gasiorowicz, Mari] Wisconsin Dept Hlth Serv, Div Publ Hlth, Madison, WI USA. RP Jeffries, WL (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,MS E37, Atlanta, GA 30333 USA. EM wjeffries@cdc.gov NR 28 TC 9 Z9 9 U1 2 U2 9 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 0899-9546 EI 1943-2755 J9 AIDS EDUC PREV JI Aids Educ. Prev. PD FEB PY 2015 VL 27 IS 1 BP 58 EP 71 PG 14 WC Education & Educational Research; Public, Environmental & Occupational Health SC Education & Educational Research; Public, Environmental & Occupational Health GA CB9EM UT WOS:000349934800005 PM 25646730 ER PT J AU Dawson, AL Tinker, SC Jamieson, DJ Hobbs, CA Rasmussen, SA Reefhuis, J AF Dawson, April L. Tinker, Sarah C. Jamieson, Denise J. Hobbs, Charlotte A. Rasmussen, Sonja A. Reefhuis, Jennita CA Natl Birth Defects Prevention TI Epidemiology of Twinning in the National Birth Defects Prevention Study, 1997 to 2007 SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Article DE twinning; ART; IVF; orofacial clefts; clomiphene citrate ID IN-VITRO FERTILIZATION; BODY-MASS INDEX; MULTIPLE BIRTHS; PERINATAL OUTCOMES; UNITED-STATES; FOLIC-ACID; RISK; TWINS; SUPPLEMENTATION; PREGNANCIES AB BackgroundOur objective was to evaluate associations between twinning and maternal demographic factors and periconceptional exposures among infants with and without orofacial clefts. MethodsWe used data from the National Birth Defects Prevention Study; 228 twins and 8242 singletons without birth defects (controls), and 117 twins and 2859 singletons with orofacial clefts, born 1997 to 2007, were included in the analyses. Because of the occurrence of twinning due to the use of assisted reproductive technologies, logistic regression models were computed to estimate odds ratios and 95% confidence intervals for each exposure, stratified by fertility treatment use. To evaluate factors by zygosity, we used sex-pairing data and a simulation approach to estimate the zygosity of like-sex twin pairs for unassisted conceptions. ResultsAmong control mothers who did not use fertility treatments, predictors of twinning included non-Hispanic black maternal race (adjusted odds ratio, 1.6; 95% confidence interval, 1.0-2.4), and tobacco smoking (adjusted odds ratio, 1.6; 95% confidence interval, 1.1-2.4). Among control mothers who used fertility treatments, older maternal age, higher income, and state of residence were associated with twinning. Associations were generally stronger among mothers of dizygotic (estimated) twins than monozygotic (estimated) twins. Results for mothers of infants with isolated orofacial clefts were similar to those of controls. ConclusionWe observed an increased twinning frequency with increasing maternal age, but factors such as maternal race/ethnicity and socioeconomic status may also contribute. Among women receiving fertility treatments, factors associated with twinning suggested a relation with treatment specifics (e.g., treatment type and number of embryos implanted) and availability of insurance coverage. Birth Defects Research (Part A) 103:85-99, 2015 (c) 2014 Wiley Periodicals, Inc. C1 [Dawson, April L.; Tinker, Sarah C.; Reefhuis, Jennita] Ctr Dis Control & Prevent CDC, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Dawson, April L.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Jamieson, Denise J.] CDC, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Hobbs, Charlotte A.] Univ Arkansas Med Sci, Coll Med, Little Rock, AR 72205 USA. [Rasmussen, Sonja A.] CDC, Off Infect Dis, Atlanta, GA 30333 USA. RP Dawson, AL (reprint author), 1600 Clifton Rd,MS E86, Atlanta, GA 30333 USA. EM isp3@cdc.gov FU Centers for Disease Control and Prevention [PA 96043, PA 02081, FOA DD09-001]; U.S. Department of Energy; CDC FX This research was supported in part by appointments to the Research Participation Program at the Centers for Disease Control and Prevention administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and CDC. This work was supported through cooperative agreements under PA 96043, PA 02081, and FOA DD09-001 from the Centers for Disease Control and Prevention to the Centers for Birth Defects Research and Prevention participating in the National Birth Defects Prevention Study. NR 44 TC 3 Z9 3 U1 2 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD FEB PY 2015 VL 103 IS 2 BP 85 EP 99 DI 10.1002/bdra.23325 PG 15 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA CC6JF UT WOS:000350470500003 PM 25359509 ER PT J AU Razzaghi, H Dawson, A Grosse, SD Allori, AC Kirby, RS Olney, RS Correia, J Cassell, CH AF Razzaghi, Hilda Dawson, April Grosse, Scott D. Allori, Alexander C. Kirby, Russell S. Olney, Richard S. Correia, Jane Cassell, Cynthia H. TI Factors Associated with High Hospital Resource Use in a Population-Based Study of Children with Orofacial Clefts SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Article DE orofacial clefts; health services research; resource use; hospitalization; cost; cleft lip; cleft palate ID BIRTH-DEFECTS PREVENTION; PRENATAL-DIAGNOSIS; UNITED-STATES; CARE; CLASSIFICATION; REGRESSION; REGISTRY; POISSON; INFANTS; WEIGHT AB BackgroundLittle is known about population-based maternal, child, and system characteristics associated with high hospital resource use for children with orofacial clefts (OFC) in the US. MethodsThis was a statewide, population-based, retrospective observational study of children with OFC born between 1998 and 2006, identified by the Florida Birth Defects Registry whose records were linked with longitudinal hospital discharge records. We stratified the descriptive results by cleft type [cleft lip with cleft palate, cleft lip, and cleft palate] and by isolated versus nonisolated OFC (accompanied by other coded major birth defects). We used Poisson regression to analyze associations between selected characteristics and high hospital resource use (90(th) percentile of estimated hospitalized days and inpatient costs) for birth, postbirth, and total hospitalizations initiated before age 2 years. RESULTSOur analysis included 2,129 children with OFC. Infants who were born low birth weight (<2500 grams) were significantly more likely to have high birth hospitalization costs for CLP (adjusted prevalence ratio: 1.6 [95% confidence interval: 1.0-2.7]), CL (adjusted prevalence ratio: 3.0 [95% confidence interval: 1.1-8.1]), and CP (adjusted prevalence ratio: 2.3 [95% confidence interval: 1.3-4.0]). Presence of multiple birth defects was significantly associated with a three- to eleven-fold and a three- to nine-fold increase in the prevalence of high costs and number of hospitalized days, respectively; at birth, postbirth before age 2 years and overall hospitalizations. ConclusionChildren with cleft palate had the greatest hospital resources use. Additionally, the presence of multiple birth defects contributed to greater inpatient days and costs for children with OFC. Birth Defects Research (Part A) 103:127-143, 2015 (c) 2015 Wiley Periodicals, Inc. C1 [Razzaghi, Hilda; Dawson, April; Grosse, Scott D.; Olney, Richard S.; Cassell, Cynthia H.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Razzaghi, Hilda] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Allori, Alexander C.] Duke Univ Hosp, Div Plast Maxillofacial & Oral Surg, Duke Cleft & Craniofacial Ctr, Durham, NC USA. [Allori, Alexander C.] Childrens Hlth Ctr, Durham, NC USA. [Kirby, Russell S.] Univ S Florida, Coll Publ Hlth, Dept Community & Family Hlth, Birth Defects Surveillance Program, Tampa, FL USA. [Correia, Jane] Florida Dept Hlth, Florida Birth Defects Registry, Bur Epidemiol, Div Dis Control & Hlth Protect, Tallahassee, FL USA. RP Razzaghi, H (reprint author), CDC, NCBDDD, 1600 Clifton Rd MS E86, Atlanta, GA 30333 USA. EM hir2@cdc.gov OI Allori, Alexander/0000-0003-3334-9877 FU March of Dimes Foundation FX The authors thank the March of Dimes Foundation for providing funding for various aspects of this project. The authors also thank the entire staff of the FBDR within the FDOH, the Children's Medical Services Program, and the Florida AHCA. Without these agencies, these data could not have been obtained. We also thank Jason Salemi, PhD, MPH, with the University of South Florida and Marie Bailey, MA, with FDOH for consultations on data linkages and variables. We also thank Adrienne Henderson, MPH, and Gloria Barker with AHCA, Florida Center for Health Information and Policy Analysis, and Karen Freeman, MPH, MS, with FDOH for consultations on hospital discharge data and hospitals.; Financial Disclosure: The authors have no financial relationships relevant to this article to disclose. Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 35 TC 3 Z9 3 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD FEB PY 2015 VL 103 IS 2 BP 127 EP 143 DI 10.1002/bdra.23356 PG 17 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA CC6JF UT WOS:000350470500008 PM 25721952 ER PT J AU Ludema, C Doherty, IA White, BL Simpson, CA Villar-Loubet, O McLellan-Lemal, E O'Daniels, CM Adimora, AA AF Ludema, Christina Doherty, Irene A. White, Becky L. Simpson, Cathy A. Villar-Loubet, Olga McLellan-Lemal, Eleanor O'Daniels, Christine M. Adimora, Adaora A. TI Religiosity, Spirituality, and HIV Risk Behaviors among African American Women from Four Rural Counties in the Southeastern US SO JOURNAL OF HEALTH CARE FOR THE POOR AND UNDERSERVED LA English DT Article DE Religion; spirituality; African American; women; sexual behavior; HIV risk; and sex partner ID SEXUAL-BEHAVIOR; UNITED-STATES; ADOLESCENT FEMALES; DRUG-USE; HIV/AIDS; INFECTION; EPIDEMIOLOGY; DETERMINANTS; INVOLVEMENT; PREVENTION AB In a cross-sectional survey of 1,013 African American women from rural Alabama and North Carolina, we examined the relationship of (1) organizational religiosity (i.e., religious service attendance), (2) non-organizational religiosity (e.g., reading religious materials), and (3) spirituality with these outcomes: women's reports of their sexual behaviors and perceptions of their partners' risk characteristics. Women with high non-organizational religiosity, compared with low, had fewer sex partners in the past 12 months (adjusted prevalence ratio (aPR): 0.58, 95% confidence interval (CI): 0.42, 0.80) and were less likely to have concurrent partnerships (aPR: 0.47, 95% CI: 0.30, 0.73). Similar results were observed for spirituality, and protective but weaker associations were observed for organizational religiosity Weak associations were observed between organizational religiosity, non-organizational religiosity, and spirituality with partners' risk characteristics. Further exploration of how religiosity and spirituality are associated with protective sexual behaviors is needed to promote safe sex for African American women. C1 [Ludema, Christina; White, Becky L.; Adimora, Adaora A.] Univ N Carolina, Sch Med, Chapel Hill, NC USA. [Doherty, Irene A.] RTI Int, Res Triangle Pk, NC USA. [Simpson, Cathy A.] Univ Alabama Birmingham, Birmingham, AL USA. [Villar-Loubet, Olga] Univ Miami, Miller Sch Med, Div Psychol, Miami, FL 33136 USA. [McLellan-Lemal, Eleanor; O'Daniels, Christine M.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Off Infect Dis, Atlanta, GA USA. RP Ludema, C (reprint author), CB 7030,Bioinformat Bldg, Chapel Hill, NC 27599 USA. EM ludema@email.unc.edu OI Ludema, Christina/0000-0003-0779-810X FU Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA [PS05-107] FX Funding for this study was provided by the Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA under cooperative agreement PS05-107. The findings and conclusions in this report are those of the author and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 41 TC 0 Z9 0 U1 1 U2 4 PU JOHNS HOPKINS UNIV PRESS PI BALTIMORE PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD 21218-4363 USA SN 1049-2089 EI 1548-6869 J9 J HEALTH CARE POOR U JI J. Health Care Poor Underserved PD FEB PY 2015 VL 26 IS 1 BP 168 EP 181 PG 14 WC Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA CC7BO UT WOS:000350522900016 PM 25702735 ER PT J AU Mack, KA Zhang, K Paulozzi, L Jones, C AF Mack, Karin A. Zhang, Kun Paulozzi, Leonard Jones, Christopher TI Prescription Practices involving Opioid Analgesics among Americans with Medicaid, 2010 SO JOURNAL OF HEALTH CARE FOR THE POOR AND UNDERSERVED LA English DT Article DE Medicaid; opioids; prescription drugs; overdose ID CHRONIC NONCANCER PAIN; VITAL SIGNS OVERDOSES; UNITED-STATES; CLAIMS DATA; THERAPY; DEATHS; TRENDS; GUIDELINES; RECIPIENTS; RELIEVERS AB Recent state-based studies have shown an increased risk of opioid overdose death in Medicaid populations. To explore one side of risk, this study examines indicators of potential opioid inappropriate use or prescribing among Medicaid enrollees. We examined claims from enrollees aged 18-64 years in the 2010 Truven Health MarketScan (R) Multi-State Medicaid database, which consisted of weighted and nationally representative data from 12 states. Pharmaceutical claims were used to identify enrollees (n=359,368) with opioid prescriptions. Indicators of potential inappropriate use or prescribing included overlapping opioid prescriptions, overlapping opioid and benzodiazepine prescriptions, long acting/extended release opioids for acute pain, and high daily doses. In 2010, Medicaid enrollees with opioid prescriptions obtained an average 6.3 opioid prescriptions, and 40% had at least one indicator of potential inappropriate use or prescribing. These indicators have been linked to opioid-related adverse health outcomes, and methods exist to detect and deter inappropriate use and prescribing of opioids. C1 [Mack, Karin A.; Zhang, Kun; Paulozzi, Leonard; Jones, Christopher] CDC, Atlanta, GA 30333 USA. RP Mack, KA (reprint author), Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Div Anal Res & Practice Integrat, 4770 Buford Hwy NE F62, Atlanta, GA 30341 USA. FU Intramural CDC HHS [CC999999] NR 35 TC 12 Z9 12 U1 0 U2 3 PU JOHNS HOPKINS UNIV PRESS PI BALTIMORE PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD 21218-4363 USA SN 1049-2089 EI 1548-6869 J9 J HEALTH CARE POOR U JI J. Health Care Poor Underserved PD FEB PY 2015 VL 26 IS 1 BP 182 EP 198 PG 17 WC Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA CC7BO UT WOS:000350522900017 PM 25702736 ER PT J AU Teshale, EH Denniston, MM Drobeniuc, J Kamili, S Teo, CG Holmberg, SD AF Teshale, Eyasu H. Denniston, Maxine M. Drobeniuc, Jan Kamili, Saleem Teo, Chong-Gee Holmberg, Scott D. TI Decline in Hepatitis E Virus Antibody Prevalence in the United States From 1988-1994 to 2009-2010 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE Hepatitis E virus; seroprevalence; NHANES; anti-HEV; IgG assay ID BLOOD-DONORS; SEROPREVALENCE; TRANSMISSION; INFECTION; ASSAYS; EPIDEMIOLOGY; SURVEILLANCE; POPULATION; COUNTRIES; OUTBREAK AB Background. Previous population-based estimates in the United States have shown a relatively high prevalence of hepatitis E virus (HEV) antibody. We sought to determine whether changes in the prevalence of HEV antibody have occurred over time. Methods. We analyzed data from the 2009-2010 National Health and Nutrition Examination Survey (NHANES) and NHANES III (1988-1994). Using the same serologic assay, we compared the estimated anti-HEV immunoglobulin G (IgG) prevalence and risk factors for antibody positivity for the 2 periods. Results. The prevalence of HEV antibody among those aged >= 6 years declined from 10.2% (95% confidence interval [CI], 9.1%-11.4%) during 1988-1994 to 6.0% (5.2%-6.8%) during 2009-2010, and the prevalence for those of US birth ranged from 9.6% (8.4%-10.9%) to 5.2% (4.4%-6.2%). Among US-born persons, the estimated HEV antibody prevalence declined significantly for all subgroups of age, sex, region of residence, and number of persons per room in the household; significant declines also were observed for persons at or above poverty level and for persons of non-Hispanic white, non-Hispanic black, and Mexican American race/ethnicity. No clear associations with food consumption were found. Conclusions. The anti-HEV prevalence is declining in the United States. Although the decline suggests a decrease in exposure to HEV over time, the risks associated with exposure remain unknown. C1 [Teshale, Eyasu H.; Denniston, Maxine M.; Drobeniuc, Jan; Kamili, Saleem; Teo, Chong-Gee; Holmberg, Scott D.] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA USA. RP Teshale, EH (reprint author), 1600 Clifton Rd,MS G-37, Atlanta, GA 30333 USA. EM eteshale@cdc.gov FU Divisions of Viral Hepatitis at the Centers for Disease Control and Prevention FX This work was supported by the Divisions of Viral Hepatitis at the Centers for Disease Control and Prevention. NR 30 TC 12 Z9 14 U1 0 U2 6 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD FEB 1 PY 2015 VL 211 IS 3 BP 366 EP 373 DI 10.1093/infdis/jiu466 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CC3CG UT WOS:000350221500006 PM 25147277 ER PT J AU Coleman, BN Apelberg, BJ Ambrose, BK Green, KM Choiniere, CJ Bunnell, R King, BA AF Coleman, Blair N. Apelberg, Benjamin J. Ambrose, Bridget K. Green, Kerry M. Choiniere, Conrad J. Bunnell, Rebecca King, Brian A. TI Association Between Electronic Cigarette Use and Openness to Cigarette Smoking Among US Young Adults SO NICOTINE & TOBACCO RESEARCH LA English DT Article ID NICOTINE DELIVERY-SYSTEMS; FUTURE SMOKING; ADOLESCENTS; AWARENESS; BEHAVIOR; TOBACCO AB Introduction: Use of electronic nicotine delivery systems (ENDS), including electronic cigarettes (e-cigarettes), is increasing. One concern is the appeal of these products to youth and young adults and the potential to influence perceptions and use of conventional cigarettes. Methods: Using data from the 2012-2013 National Adult Tobacco Survey, characteristics of adults aged 18-29 years who had never established cigarette smoking behavior were examined by ever use of e-cigarettes, demographics, and ever use of other tobacco products (smokeless tobacco, cigars, hookah, and cigarettes). Multivariate logistic regression was used to examine the relationship between e-cigarette use and openness to cigarette smoking among young adults, defined as the lack of a firm intention not to smoke soon or in the next year. Results: Among young adults who had never established cigarette smoking behavior (unweighted n = 4,310), 7.9% reported having ever tried e-cigarettes, and 14.6% of those who reported having ever tried e-cigarettes also reported current use of the product. Ever e-cigarette use was associated with being open to cigarette smoking (adjusted odds ratio = 2.4; 95% confidence interval = 1.7, 3.3), as was being male, aged 18-24 years, less educated, and having ever used hookah or experimented with conventional cigarettes. Conclusions: Ever use of e-cigarettes and other tobacco products was associated with being open to cigarette smoking. This study does not allow us to assess the directionality of this association, so future longitudinal research is needed to illuminate tobacco use behaviors over time as well as provide additional insight on the relationship between ENDS use and conventional cigarette use among young adult populations. C1 [Coleman, Blair N.; Apelberg, Benjamin J.; Ambrose, Bridget K.; Choiniere, Conrad J.] US FDA, Ctr Tobacco Prod, Off Sci, Silver Spring, MD 20993 USA. [Coleman, Blair N.; Green, Kerry M.] Univ Maryland, Sch Publ Hlth, Dept Behav & Community Hlth, College Pk, MD 20742 USA. [Bunnell, Rebecca; King, Brian A.] Ctr Dis Control & Prevent, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Coleman, BN (reprint author), US FDA, Ctr Tobacco Prod, Off Sci, 10903 New Hampshire Ave, Silver Spring, MD 20993 USA. EM blair.coleman@fda.hhs.gov NR 30 TC 33 Z9 33 U1 3 U2 21 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1462-2203 EI 1469-994X J9 NICOTINE TOB RES JI Nicotine Tob. Res. PD FEB PY 2015 VL 17 IS 2 SI SI BP 212 EP 218 DI 10.1093/ntr/ntu211 PG 7 WC Substance Abuse; Public, Environmental & Occupational Health SC Substance Abuse; Public, Environmental & Occupational Health GA CC1YW UT WOS:000350142300016 PM 25378683 ER PT J AU King, BA Patel, R Nguyen, KH Dube, SR AF King, Brian A. Patel, Roshni Nguyen, Kimberly H. Dube, Shanta R. TI Trends in Awareness and Use of Electronic Cigarettes Among US Adults, 2010-2013 SO NICOTINE & TOBACCO RESEARCH LA English DT Article ID NICOTINE DELIVERY-SYSTEMS; DEVICE E-CIGARETTE; SMOKING REDUCTION; CESSATION; TOBACCO; HEALTH AB Introduction: Electronic cigarette (e-cigarette) marketing has increased considerably since the product entered the US market in 2007, thereby warranting additional surveillance to monitor recent trends in population-level awareness and utilization. We assessed the prevalence, characteristics, and trends in e-cigarette awareness and use among nationally representative samples of US adults during 2010-2013. Methods: Data came from the 2010-2013 HealthStyles survey, an annual consumer-based web survey of US adults aged >= 18 years. Sample sizes ranged from 2,505 (2010) to 4,170 (2012). Descriptive statistics were used to assess e-cigarette awareness, ever use, and current use (use within the past 30 days) overall and by sex, age, race/ethnicity, education, income, US region, and cigarette smoking status. Trends were assessed using logistic regression. Results: During 2010-2013, increases (p < .05) were observed for e-cigarette awareness (40.9%-79.7%), ever use (3.3%-8.5%), and current use (1.0%-2.6%). Awareness increased among all socio-demographic subpopulations during 2010-2013 (p < .05); an increase in ever use of e-cigarettes occurred among all sociodemographic groups except those aged 18-24 years, Hispanics, and those living in the Midwest (p < .05). During 2010-2013, ever use increased among current (9.8%-36.5%) and former (2.5%-9.6%) cigarette smokers (p < .05), but it remained unchanged among never smokers (1.3%-1.2%). Conclusions: Awareness and use of e-cigarettes increased considerably among US adults during 2010-2013. In 2013, more than one-third of current cigarette smokers reported having ever used e-cigarettes. Given the uncertain public health impact of e-cigarettes, continued surveillance of emerging use patterns is critical for public health planning. C1 [King, Brian A.; Nguyen, Kimberly H.] Ctr Dis Control & Prevent, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Patel, Roshni] DB Consulting Grp, Atlanta, GA USA. [Dube, Shanta R.] Georgia State Univ, Div Epidemiol & Biostat, Sch Publ Hlth, Atlanta, GA 30303 USA. RP King, BA (reprint author), Ctr Dis Control & Prevent, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy,MS F-79, Atlanta, GA 30341 USA. EM baking@cdc.gov FU Intramural CDC HHS [CC999999] NR 41 TC 119 Z9 120 U1 7 U2 27 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1462-2203 EI 1469-994X J9 NICOTINE TOB RES JI Nicotine Tob. Res. PD FEB PY 2015 VL 17 IS 2 SI SI BP 219 EP 227 DI 10.1093/ntr/ntu191 PG 9 WC Substance Abuse; Public, Environmental & Occupational Health SC Substance Abuse; Public, Environmental & Occupational Health GA CC1YW UT WOS:000350142300017 PM 25239961 ER PT J AU Bunnell, RE Agaku, IT Arrazola, RA Apelberg, BJ Caraballo, RS Corey, CG Coleman, BN Dube, SR King, BA AF Bunnell, Rebecca E. Agaku, Israel T. Arrazola, Rene A. Apelberg, Benjamin J. Caraballo, Ralph S. Corey, Catherine G. Coleman, Blair N. Dube, Shanta R. King, Brian A. TI Intentions to Smoke Cigarettes Among Never-Smoking US Middle and High School Electronic Cigarette Users: National Youth Tobacco Survey, 2011-2013 SO NICOTINE & TOBACCO RESEARCH LA English DT Article ID FUTURE SMOKING; PUBLIC-HEALTH; UNITED-STATES; U.S. ADULTS; SUSCEPTIBILITY; ADOLESCENTS; INITIATION; PREDICTOR; STUDENTS AB Introduction: Electronic cigarette (e-cigarette) use is increasing rapidly, and the impact on youth is unknown. We assessed associations between e-cigarette use and smoking intentions among US youth who had never smoked conventional cigarettes. Methods: We analyzed data from the nationally representative 2011, 2012, and 2013 National Youth Tobacco Surveys of students in grades 6-12. Youth reporting they would definitely not smoke in the next year or if offered a cigarette by a friend were defined as not having an intention to smoke; all others were classified as having positive intention to smoke conventional cigarettes. Demographics, pro-tobacco advertisement exposure, ever use of e-cigarettes, and ever use of other combustibles (cigars, hookah, bidis, kreteks, and pipes) and noncombustibles (chewing tobacco, snuff, dip, snus, and dissolvables) were included in multivariate analyses that assessed associations with smoking intentions among never-cigarette-smoking youth. Results: Between 2011 and 2013, the number of never-smoking youth who used e-cigarettes increased 3-fold, from 79,000 to more than 263,000. Intention to smoke conventional cigarettes was 43.9% among ever e-cigarette users and 21.5% among never users. Ever e-cigarette users had higher adjusted odds for having smoking intentions than never users (adjusted odds ratio = 1.70, 95% confidence interval = 1.24-2.32). Those who ever used other combustibles, ever used noncombustibles, or reported pro-tobacco advertisement exposure also had increased odds for smoking intentions. Conclusion: In 2013, more than a quarter million never-smoking youth used e-cigarettes. E-cigarette use is associated with increased intentions to smoke cigarettes, and enhanced prevention efforts for youth are important for all forms of tobacco, including e-cigarettes. C1 [Bunnell, Rebecca E.; Agaku, Israel T.; Arrazola, Rene A.; Caraballo, Ralph S.; King, Brian A.] Ctr Dis Control & Prevent, Off Smoking & Hlth, Atlanta, GA 30341 USA. [Apelberg, Benjamin J.; Corey, Catherine G.; Coleman, Blair N.] US FDA, Off Sci, Ctr Tobacco Prod, Rockville, MD 20857 USA. [Dube, Shanta R.] Georgia State Univ, Sch Publ Hlth, Div Epidemiol & Biostat, Atlanta, GA 30303 USA. RP Bunnell, RE (reprint author), Ctr Dis Control & Prevent, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy,MS F-79, Atlanta, GA 30341 USA. EM rrb7@cdc.gov FU Intramural CDC HHS [CC999999] NR 37 TC 97 Z9 98 U1 6 U2 38 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1462-2203 EI 1469-994X J9 NICOTINE TOB RES JI Nicotine Tob. Res. PD FEB PY 2015 VL 17 IS 2 SI SI BP 228 EP 235 DI 10.1093/ntr/ntu166 PG 8 WC Substance Abuse; Public, Environmental & Occupational Health SC Substance Abuse; Public, Environmental & Occupational Health GA CC1YW UT WOS:000350142300018 PM 25143298 ER PT J AU Brook, CE Bai, Y Dobson, AP Osikowicz, LM Ranaivoson, HC Zhu, QY Kosoy, MY Dittmar, K AF Brook, Cara E. Bai, Ying Dobson, Andrew P. Osikowicz, Lynn M. Ranaivoson, Hafaliana C. Zhu, Qiyun Kosoy, Michael Y. Dittmar, Katharina TI Bartonella spp. in Fruit Bats and Blood-Feeding Ectoparasites in Madagascar SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID NYCTERIBIIDAE; TRANSMISSION; RESERVOIR; DIPTERA; AFRICA AB We captured, ectoparasite-combed, and blood-sampled cave-roosting Madagascan fruit bats (Eidolon dupreanum) and tree-roosting Madagascan flying foxes (Pteropus rufus) in four single-species roosts within a sympatric geographic foraging range for these species in central Madagascar. We describe infection with novel Bartonella spp. in sampled Eidolon dupreanum and associated bat flies (Cyclopodia dubia), which nest close to or within major known Bartonella lineages; simultaneously, we report the absence of Bartonella spp. in Thaumapsylla sp. fleas collected from these same bats. This represents the first documented finding of Bartonella infection in these species of bat and bat fly, as well as a new geographic record for Thaumapsylla sp. We further relate the absence of both Bartonella spp. and ectoparasites in sympatrically sampled Pteropus rufus, thus suggestive of a potential role for bat flies in Bartonella spp. transmission. These findings shed light on transmission ecology of bat-borne Bartonella spp., recently demonstrated as a potentially zoonotic pathogen. C1 [Brook, Cara E.; Dobson, Andrew P.] Princeton Univ, Dept Ecol & Evolutionary Biol, Princeton, NJ 08544 USA. [Bai, Ying; Osikowicz, Lynn M.; Kosoy, Michael Y.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA. [Ranaivoson, Hafaliana C.] Inst Pasteur Madagascar, Virol Unit, Antananarivo, Madagascar. [Zhu, Qiyun; Dittmar, Katharina] SUNY Buffalo, Dept Biol Sci, Buffalo, NY 14260 USA. RP Brook, CE (reprint author), Princeton Univ, Dept Ecol & Evolutionary Biol, Princeton, NJ 08544 USA. EM caraeb@princeton.edu FU National Geographic Society Young Explorer's Grant (YEG) [926-13]; Princeton University Center for Health and Wellbeing Health Grand Challenge grant; National Science Foundation Division of Environmental Biology [1050793]; National Science Foundation [23400 G0001 10004452] FX Field work was supported via the following three small grants to CEB: [1] National Geographic Society Young Explorer's Grant to CEB (YEG #926-13, http://www.nationalgeographic.com/explorers/grants-programs/young-explor ers/), [2] Princeton University Center for Health and Wellbeing Health Grand Challenge grant (http://www.princeton.edu/chw/education/grad-research-funding/graduatere search-funding-HGC/), [3] American Society of Mammalogists Grant-in-Aid of Research (http://www.mammalsociety.org/committees/grants-aid). Sample analysis was funded by a National Science Foundation Division of Environmental Biology grant (#:1050793) to KD. Publication fees were covered by a National Science Foundation grant (#:23400 G0001 10004452) to APD. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 22 TC 6 Z9 7 U1 1 U2 15 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD FEB PY 2015 VL 9 IS 2 AR UNSP e0003532 DI 10.1371/journal.pntd.0003532 PG 9 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CD3PW UT WOS:000350992500055 PM 25706653 ER PT J AU LaBeaud, AD Banda, T Brichard, J Muchiri, EM Mungai, PL Mutuku, FM Borland, E Gildengorin, G Pfeil, S Teng, CY Long, K Heise, M Powers, AM Kitron, U King, CH AF LaBeaud, A. Desiree Banda, Tamara Brichard, Julie Muchiri, Eric M. Mungai, Peter L. Mutuku, Francis M. Borland, Erin Gildengorin, Ginny Pfeil, Sarah Teng, Crystal Y. Long, Kristin Heise, Mark Powers, Ann M. Kitron, Uriel King, Charles H. TI High Rates of O'Nyong Nyong and Chikungunya Virus Transmission in Coastal Kenya SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID NORTHERN TANZANIA; FEVER; INFECTIONS; MORBIDITY; ARBOVIRUS; PATTERNS AB Background Chikungunya virus (CHIKV) and o'nyong nyong virus (ONNV) are mosquito-borne alpha-viruses endemic in East Africa that cause acute febrile illness and arthritis. The objectives of this study were to measure the seroprevalence of CHIKV and ONNV in coastal Kenya and link it to demographics and other risk factors. Methodology Demographic and exposure questionnaires were administered to 1,848 participants recruited from two village clusters (Milalani-Nganja and Vuga) in 2009. Sera were tested for alphavirus exposure using standardized CHIKV IgG ELISA protocols and confirmed with plaque reduction neutralization tests (PRNT). Logistic regression models were used to determine the variables associated with seropositivity. Weighted K test for global clustering of houses with alphavirus positive participants was performed for distance ranges of 50-1,000 meters, and G* statistic and kernel density mapping were used to identify locations of higher seroprevalence. Principal Findings 486 (26%) participants were seropositive by IgG ELISA. Of 443 PRNT confirmed positives, 25 samples (6%) were CHIKV+, 250 samples (56%) were ONNV+, and 168 samples (38%) had high titers for both. Age was significantly associated with seropositivity (OR 1.01 per year, 95% C.I. 1.00-1.01); however, younger adults were more likely to be seropositive than older adults. Males were less likely to be seropositive (p<0.05; OR 0.79, 95% C.I. 0.64-0.97). Adults who owned a bicycle (p<0.05; OR 1.37, 95% C.I. 1.00-1.85) or motor vehicle (p<0.05; OR 4.64, 95% C.I. 1.19-18.05) were more likely to be seropositive. Spatial analysis demonstrated hotspots of transmission within each village and clustering among local households in Milalani-Nganja, peaking at the 200-00m range. Conclusions/Significance Alphavirus exposure, particularly ONNV exposure, is common in coastal Kenya with ongoing interepidemic transmission of both ONNV and CHIKV. Women and adults were more likely to be seropositive. Household location may be a defining factor for the ecology of alphaviral transmission in this region. C1 [LaBeaud, A. Desiree; Banda, Tamara; Brichard, Julie; Gildengorin, Ginny; Pfeil, Sarah; Teng, Crystal Y.] Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USA. [Mungai, Peter L.; King, Charles H.] Case Western Reserve Univ, Cleveland, OH 44106 USA. [Muchiri, Eric M.] Minist Hlth, Div Vector Borne & Neglected Trop Dis, Msambweni, Kenya. [Mutuku, Francis M.] Tech Univ Mombasa, Mombasa, Kenya. [Borland, Erin; Powers, Ann M.] CDC, Ft Collins, CO USA. [Long, Kristin; Heise, Mark] Univ N Carolina, Chapel Hill, NC USA. [Kitron, Uriel] Emory Univ, Atlanta, GA 30322 USA. RP LaBeaud, AD (reprint author), Stanford Univ, Dept Pediat, Div Infect Dis, Stanford, CA 94305 USA. EM dlabeaud@stanford.edu OI King, Charles/0000-0001-8349-9270 FU PNWRCE [AI81680:RP012]; NIH [AI102918]; NIH/NSF EEID [TW008067] FX This work was supported by PNWRCE AI81680:RP012 (PI: LaBeaud), NIH AI102918 (PI: LaBeaud), and NIH/NSF EEID TW008067 (PIs: Kitron and King). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 20 TC 4 Z9 4 U1 1 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD FEB PY 2015 VL 9 IS 2 AR UNSP e0003436 DI 10.1371/journal.pntd.0003436 PG 14 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CD3PW UT WOS:000350992500014 PM 25658762 ER PT J AU Martin, DL Bid, R Sandi, F Goodhew, EB Massae, PA Lasway, A Philippin, H Makupa, W Molina, S Holland, MJ Mabey, DCW Drakeley, C Lammie, PJ Solomon, AW AF Martin, Diana L. Bid, Rhiannon Sandi, Frank Goodhew, E. Brook Massae, Patrick A. Lasway, Augustin Philippin, Heiko Makupa, William Molina, Sandra Holland, Martin J. Mabey, David C. W. Drakeley, Chris Lammie, Patrick J. Solomon, Anthony W. TI Serology for Trachoma Surveillance after Cessation of Mass Drug Administration SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID CHLAMYDIA-TRACHOMATIS; ACTIVE TRACHOMA; INFECTION; AZITHROMYCIN; PREVALENCE; COMMUNITY; TESTS AB Background Trachoma, caused by Chlamydia trachomatis (Ct), is the leading infectious cause of blindness worldwide. Yearly azithromycin mass drug administration (MDA) plays a central role in efforts to eliminate blinding trachoma as a public health problem. Programmatic decision-making is currently based on the prevalence of the clinical sign "trachomatous inflammation-follicular" (TF) in children. We sought to test alternative tools for trachoma surveillance based on serology in the 12-year cohort of Kahe Mpya, Rombo District, Tanzania, where ocular chlamydial infection was eliminated with azithromycin MDA by 2005. Methodology and Principal Findings The present study was a community-based cross-sectional survey in Kahe Mpya. Of 989 residents, 571 people aged 6 months to 87 years were enrolled: 58% of the total population and 73% of 1-9 year olds, the key WHO indicator age group. Participants were examined for TF, had conjunctival swabs collected for nucleic acid amplification test (NAAT)-based detection of Ct, and blood collected for analysis of antibodies to the Ct antigens pgp3 and CT694 by multiplex bead-based immunoassay. Seroconversion rate was used to estimate changes in the force of infection in a reversible catalytic model. No conjunctival swabs tested positive for Ct infection by NAAT. Among 1-9 year olds, TF prevalence was 6.5%, whereas only 3.5% were seropositive. Force of infection modelling indicated a 10-fold decrease in seroconversion rate at a time corresponding to MDA commencement. Without baseline serological data, the inferences we can make about antibody status before MDA and the longevity of the antibody response are limited, though our use of catalytic modelling overcomes some of these limitations. Conclusions/Significance Serologic tests support NAAT findings of very low to zero prevalence of ocular Ct in this community and have potential to provide objective measures of transmission and useful surveillance tools for trachoma elimination programs. C1 [Martin, Diana L.; Goodhew, E. Brook; Lammie, Patrick J.] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA 30333 USA. [Bid, Rhiannon; Philippin, Heiko; Molina, Sandra; Holland, Martin J.; Mabey, David C. W.; Solomon, Anthony W.] London Sch Hyg & Trop Med, Dept Clin Res, Fac Infect & Trop Dis, London WC1, England. [Sandi, Frank] Kilimanjaro Christian Med Univ Coll, Moshi, Tanzania. [Sandi, Frank] Univ Dodoma, Dodoma, Tanzania. [Massae, Patrick A.; Philippin, Heiko; Makupa, William] Kilimanjaro Christian Med Ctr, Dept Ophthalmol, Moshi, Tanzania. [Lasway, Augustin] Huruma Hosp, Mkuu, Tanzania. [Drakeley, Chris] London Sch Hyg & Trop Med, Dept Immunol & Infect, Fac Infect & Trop Dis, London WC1, England. RP Martin, DL (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA 30333 USA. OI Mabey, David/0000-0002-0031-8276; Philippin, Heiko/0000-0002-5380-6994; Solomon, Anthony/0000-0001-7101-6649 FU USAID FX USAID funded this study under an Interagency Agreement with CDC awarded to DLM. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 32 TC 17 Z9 18 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD FEB PY 2015 VL 9 IS 2 AR e0003555 DI 10.1371/journal.pntd.0003555 PG 11 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CD3PW UT WOS:000350992500063 PM 25714363 ER PT J AU Parsons, MB Travis, D Lonsdorf, EV Lipende, I Roellig, DMA Kamenya, S Zhang, HW Xiao, LH Gillespie, TR AF Parsons, Michele B. Travis, Dominic Lonsdorf, Elizabeth V. Lipende, Iddi Roellig, Dawn M. Anthony Kamenya, Shadrack Zhang, Hongwei Xiao, Lihua Gillespie, Thomas R. TI Epidemiology and Molecular Characterization of Cryptosporidium spp. in Humans, Wild Primates, and Domesticated Animals in the Greater Gombe Ecosystem, Tanzania SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID IMPENETRABLE NATIONAL-PARK; HUMAN-IMMUNODEFICIENCY-VIRUS; GORILLA-GORILLA-BERINGEI; MOUNTAIN GORILLAS; WESTERN UGANDA; CLINICAL-MANIFESTATIONS; ENTEROCYTOZOON-BIENEUSI; BACTERIAL TRANSMISSION; PERSISTENT DIARRHEA; ADULT PATIENTS AB Cryptosporidium is an important zoonotic parasite globally. Few studies have examined the ecology and epidemiology of this pathogen in rural tropical systems characterized by high rates of overlap among humans, domesticated animals, and wildlife. We investigated risk factors for Cryptosporidium infection and assessed cross-species transmission potential among people, non-human primates, and domestic animals in the Gombe Ecosystem, Kigoma District, Tanzania. A cross-sectional survey was designed to determine the occurrence and risk factors for Cryptosporidium infection in humans, domestic animals and wildlife living in and around Gombe National Park. Diagnostic PCR revealed Cryptosporidium infection rates of 4.3% in humans, 16.0% in non-human primates, and 9.6% in livestock. Local streams sampled were negative. DNA sequencing uncovered a complex epidemiology for Cryptosporidium in this system, with humans, baboons and a subset of chimpanzees infected with C. hominis subtype IfA12G2; another subset of chimpanzees infected with C. suis; and all positive goats and sheep infected with C. xiaoi. For humans, residence location was associated with increased risk of infection in Mwamgongo village compared to one camp ( Kasekela), and there was an increased odds for infection when living in a household with another positive person. Fecal consistency and other gastrointestinal signs did not predict Cryptosporidium infection. Despite a high degree of habitat overlap between village people and livestock, our results suggest that there are distinct Cryptosporidium transmission dynamics for humans and livestock in this system. The dominance of C. hominis subtype IfA12G2 among humans and non-human primates suggest cross-species transmission. Interestingly, a subset of chimpanzees was infected with C. suis. We hypothesize that there is cross-species transmission from bush pigs (Potaochoerus larvatus) to chimpanzees in Gombe forest, since domesticated pigs are regionally absent. Our findings demonstrate a complex nature of Cryptosporidium in sympatric primates, including humans, and stress the need for further studies. C1 [Parsons, Michele B.; Gillespie, Thomas R.] Emory Univ, Program Populat Biol Ecol & Evolut, Atlanta, GA 30322 USA. [Parsons, Michele B.; Gillespie, Thomas R.] Emory Univ, Dept Environm Sci, Atlanta, GA 30322 USA. [Parsons, Michele B.; Gillespie, Thomas R.] Emory Univ, Dept Environm Hlth, Atlanta, GA 30322 USA. [Parsons, Michele B.; Roellig, Dawn M. Anthony; Xiao, Lihua] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Atlanta, GA USA. [Travis, Dominic] Univ Minnesota, Coll Vet Med, Minneapolis, MN 55455 USA. [Lonsdorf, Elizabeth V.] Franklin & Marshall Coll, Dept Psychol, Lancaster, PA 17604 USA. [Lipende, Iddi; Roellig, Dawn M. Anthony; Kamenya, Shadrack] Jane Goodall Inst, Kigoma, Tanzania. [Zhang, Hongwei] Henan Ctr Dis Control & Prevent, Inst Parasite Dis Prevent & Control, Zhengzhou, Peoples R China. RP Parsons, MB (reprint author), Emory Univ, Program Populat Biol Ecol & Evolut, Atlanta, GA 30322 USA. EM thomas.gillespie@emory.edu RI Xiao, Lihua/B-1704-2013 OI Xiao, Lihua/0000-0001-8532-2727 FU Morris Animal Foundation [MAF D09ZO-041, MAF D09ZO-634]; Emory University Global Health Institute; Arcus Foundation; Leo S. Guthman Foundation; National Institutes of Health [R01 AI58715] FX Funding for this study comes from the Morris Animal Foundation (MAF D09ZO-041 and MAF D09ZO-634), the Emory University Global Health Institute, the Arcus Foundation, the Leo S. Guthman Foundation and the National Institutes of Health (R01 AI58715). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 58 TC 5 Z9 6 U1 4 U2 21 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD FEB PY 2015 VL 9 IS 2 AR UNSP e0003529 DI 10.1371/journal.pntd.0003529 PG 13 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CD3PW UT WOS:000350992500054 PM 25700265 ER PT J AU Poole-Smith, BK Hemme, RR Delorey, M Felix, G Gonzalez, AL Amador, M Hunsperger, EA Barrera, R AF Poole-Smith, B. Katherine Hemme, Ryan R. Delorey, Mark Felix, Gilberto Gonzalez, Andrea L. Amador, Manuel Hunsperger, Elizabeth A. Barrera, Roberto TI Comparison of Vector Competence of Aedes mediovittatus and Aedes aegypti for Dengue Virus: Implications for Dengue Control in the Caribbean SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID PUERTO-RICO; POPULATION-DYNAMICS; DIPTERA-CULICIDAE; ORAL INFECTION; TRANSMISSION; MOSQUITOS; SUSCEPTIBILITY; AMERICA; TEMPERATURE; MAINTENANCE AB Background Aedes mediovittatus mosquitoes are found throughout the Greater Antilles in the Caribbean and often share the same larval habitats with Ae. Aegypti, the primary vector for dengue virus (DENV). Implementation of vector control measures to control dengue that specifically target Ae. Aegypti may not control DENV transmission in Puerto Rico (PR). Even if Ae. Aegypti is eliminated or DENV refractory mosquitoes are released, DENV transmission may not cease when other competent mosquito species like Ae. Mediovittatus are present. To compare vector competence of Ae. Mediovittatus and Ae. Aegypti mosquitoes, we studied relative infection and transmission rates for all four DENV serotypes. Methods To compare the vector competence of Ae. Mediovittatus and Ae. Aegypti, mosquitoes were exposed to DENV 1-4 per os at viral titers of 5-6 logs plaque-forming unit (pfu) equivalents. At 14 days post infectious bloodmeal, viral RNA was extracted and tested by qRT-PCR to determine infection and transmission rates. Infection and transmission rates were analyzed with a generalized linear model assuming a binomial distribution. Results Ae. Aegypti had significantly higher DENV-4 infection and transmission rates than Ae. mediovittatus. Conclusions This study determined that Ae. Mediovittatus is a competent DENV vector. Therefore dengue prevention programs in PR and the Caribbean should consider both Ae. Mediovittatus and Ae. Aegypti mosquitoes in their vector control programs. C1 [Poole-Smith, B. Katherine; Hemme, Ryan R.; Felix, Gilberto; Gonzalez, Andrea L.; Amador, Manuel; Hunsperger, Elizabeth A.; Barrera, Roberto] Ctr Dis Control & Prevent, Dengue Branch, San Juan, PR 00920 USA. [Delorey, Mark] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA. RP Poole-Smith, BK (reprint author), Ctr Dis Control & Prevent, Dengue Branch, San Juan, PR 00920 USA. EM isd5@cdc.gov FU Centers for Disease Control and Prevention FX The work was funded by Centers for Disease Control and Prevention. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The findings and conclusions of this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 41 TC 6 Z9 6 U1 1 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD FEB PY 2015 VL 9 IS 2 AR e0003462 DI 10.1371/journal.pntd.0003462 PG 11 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CD3PW UT WOS:000350992500020 PM 25658951 ER PT J AU Taracena, ML Oliveira, PL Almendares, O Umana, C Lowenberger, C Dotson, EM Paiva-Silva, GO Pennington, PM AF Taracena, Mabel L. Oliveira, Pedro L. Almendares, Olivia Umana, Claudia Lowenberger, Carl Dotson, Ellen M. Paiva-Silva, Gabriela O. Pennington, Pamela M. TI Genetically Modifying the Insect Gut Microbiota to Control Chagas Disease Vectors through Systemic RNAi SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID HEME-BINDING PROTEIN; DOUBLE-STRANDED-RNA; RHODNIUS-PROLIXUS HEMIPTERA; MOSQUITO ANOPHELES-GAMBIAE; BLOODSUCKING INSECT; TRIATOMA-INFESTANS; SYMBIOTIC BACTERIA; GENE; INTERFERENCE; DSRNA AB Technologies based on RNA interference may be used for insect control. Sustainable strategies are needed to control vectors of Chagas disease such as Rhodnius prolixus. The insect microbiota can be modified to deliver molecules to the gut. Here, Escherichia coli HT115(DE3) expressing dsRNA for the Rhodnius heme-binding protein (RHBP) and for catalase (CAT) were fed to nymphs and adult triatomine stages. RHBP is an egg protein and CAT is an antioxidant enzyme expressed in all tissues by all developmental stages. The RNA interference effect was systemic and temporal. Concentrations of E. coli HT115(DE3) above 3.35 x 10(7) CFU/mL produced a significant RHBP and CAT gene knockdown in nymphs and adults. RHBP expression in the fat body was reduced by 99% three days after feeding, returning to normal levels 10 days after feeding. CAT expression was reduced by 99% and 96% in the ovary and the posterior midgut, respectively, five days after ingestion. Mortality rates increased by 24-30% in first instars fed RHBP and CAT bacteria. Molting rates were reduced by 100% in first instars and 80% in third instars fed bacteria producing RHBP or CAT dsRNA. Oviposition was reduced by 43% (RHBP) and 84% (CAT). Embryogenesis was arrested in 16% (RHBP) and 20% (CAT) of laid eggs. Feeding females 105 CFU/mL of the natural symbiont, Rhodococcus rhodnii, transformed to express RHBP-specific hairpin RNA reduced RHBP expression by 89% and reduced oviposition. Modifying the insect microbiota to induce systemic RNAi in R. prolixus may result in a paratransgenic strategy for sustainable vector control. C1 [Taracena, Mabel L.; Oliveira, Pedro L.; Paiva-Silva, Gabriela O.] Univ Fed Rio de Janeiro, Programa Biol Mol & Biotecnol, Inst Bioquim Med Leopoldo de Meis, CCS,Ilha Fundao, Rio De Janeiro, Brazil. [Taracena, Mabel L.; Umana, Claudia] Univ Valle Guatemala, ECtr Estudios Salud, Guatemala City, Guatemala. [Almendares, Olivia; Dotson, Ellen M.] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA USA. [Lowenberger, Carl; Pennington, Pamela M.] Simon Fraser Univ, Dept Biol Sci, Burnaby, BC V5A 1S6, Canada. RP Taracena, ML (reprint author), Univ Fed Rio de Janeiro, Programa Biol Mol & Biotecnol, Inst Bioquim Med Leopoldo de Meis, CCS,Ilha Fundao, Rio De Janeiro, Brazil. EM gosilva@bioqmed.ufrj.br; pamelap@uvg.edu.gt OI Oliveira, Pedro/0000-0003-0307-354X FU Fondo Nacional de Ciencia y Tecnologia, -FONACYT- of the National Secretariat for Science and Technology - SENACYT-; National Council for Science and Technology - CONCYT- of Guatemala; Latin American and Caribbean Research Exchange Grant; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior; Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro; Programa de Apoio a Nucleos de Excelencia; Howard Hughes Medical Institute FX The work was made possible by funding to PMP from Fondo Nacional de Ciencia y Tecnologia, -FONACYT- of the National Secretariat for Science and Technology - SENACYT- and the support of the National Council for Science and Technology - CONCYT- of Guatemala. CL received funding from the Latin American and Caribbean Research Exchange Grant to support CU. This work was also supported by grants from the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, the Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro, the Programa de Apoio a Nucleos de Excelencia, and the Howard Hughes Medical Institute. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 48 TC 10 Z9 10 U1 6 U2 37 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD FEB PY 2015 VL 9 IS 2 AR UNSP e0003358 DI 10.1371/journal.pntd.0003358 PG 14 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CD3PW UT WOS:000350992500003 PM 25675102 ER PT J AU Shivashankar, R Kirk, K Kim, WC Rouse, C Tandon, N Narayan, KMV Ali, MK AF Shivashankar, Roopa Kirk, Katy Kim, Woon Cho Rouse, Chaturia Tandon, Nikhil Narayan, K. M. Venkat Ali, Mahammed K. TI Quality of diabetes care in low- and middle-income Asian and Middle Eastern countries (1993-2012)-20-Year systematic review SO DIABETES RESEARCH AND CLINICAL PRACTICE LA English DT Review DE Diabetes mellitus; Quality of care; Asia; Middle East; Developing countries ID PERIPHERAL ARTERIAL-DISEASE; PLACEBO-CONTROLLED TRIAL; BLOOD-GLUCOSE CONTROL; GLYCEMIC CONTROL; RISK-FACTORS; CARDIOVASCULAR-DISEASE; VASCULAR-DISEASE; SOUTHERN INDIA; SELF-MANAGEMENT; UNITED-STATES AB Objective: To assess the extent to which people with diabetes in low-and middle-income countries (LMIC) of Asia and the Middle East met evidence-based care recommendations through a systematic review of published literature. Methods: Electronic searches of Medline and Embase were carried out for studies assessing quality of care among people with diabetes in Asia and the Middle East between 1993 and 2012. Benchmarking against American Diabetes Association guidelines, we reported level and proportions meeting recommended risk factor control (glycated hemoglobin [HbA(1)c], blood pressure, and low density lipoprotein-cholesterol [LDL]) and preventive care processes across different settings. Results: One hundred and fifteen publications met eligibility for inclusion (91 reported risk factor control, 7 reported preventive processes, and 17 reported both). Only China, Thailand, Malaysia and Philippines had nationally representative data. Mean HbA1c (6.5-11% or 4897 mmol/mol), SBP (120-152mm Hg), and LDL (2.4-3.8 mmol/l) varied greatly. Despite variation in availability of data, studies consistently showed that recommended care goals were not being achieved. Conclusions: The practice of auditing and benchmarking against evidence-based guidelines appears to be uncommon in Asia and the Middle East and there was heterogeneity of reporting across studies, populations, and methods used. The available data showed inadequate care. (C) 2014 Elsevier Ireland Ltd. All rights reserved. C1 [Shivashankar, Roopa] Ctr Chron Dis Control, New Delhi, India. [Shivashankar, Roopa] Publ Hlth Fdn India, New Delhi, India. [Kirk, Katy] E Carolina Univ, Brody Sch Med, Greenville, NC USA. [Kim, Woon Cho] Emory Univ, Sch Med, Atlanta, GA USA. [Rouse, Chaturia] Ctr Dis Control & Prevent, Atlanta, GA USA. [Tandon, Nikhil] All India Inst Med Sci, New Delhi, India. [Narayan, K. M. Venkat; Ali, Mahammed K.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. RP Shivashankar, R (reprint author), Ctr Chron Dis Control, Plot 47,Sect 44, Gurgaon 122002, India. EM roopa@ccdcindia.org FU D43 Training Program (Eunice Kennedy Shriver National Institute of Child Health & Human Development) [1D43HD05249]; National Heart, Lung, and Blood Institute (NHLBI); United Health, USA [HHSN26820090026C]; D43 Training Program (Fogarty International Center [FIC]) FX The first author (RS) and her mentors (NT, KMVN, MKA) were supported by the D43 Training Program (Award No. 1D43HD05249 of the Eunice Kennedy Shriver National Institute of Child Health & Human Development and Fogarty International Center [FIC]) & National Heart, Lung, and Blood Institute (NHLBI) and United Health, USA (Contract Award No. HHSN26820090026C). NR 155 TC 4 Z9 4 U1 4 U2 10 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0168-8227 EI 1872-8227 J9 DIABETES RES CLIN PR JI Diabetes Res. Clin. Pract. PD FEB PY 2015 VL 107 IS 2 BP 203 EP 223 DI 10.1016/j.diabres.2014.11.004 PG 21 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA CB2IJ UT WOS:000349450300003 PM 25529849 ER PT J AU Kissin, DM Zhang, Y Boulet, SL Fountain, C Bearman, P Schieve, L Yeargin-Allsopp, M Jamieson, DJ AF Kissin, D. M. Zhang, Y. Boulet, S. L. Fountain, C. Bearman, P. Schieve, L. Yeargin-Allsopp, M. Jamieson, D. J. TI Association of assisted reproductive technology (ART) treatment and parental infertility diagnosis with autism in ART-conceived children SO HUMAN REPRODUCTION LA English DT Article DE assisted reproductive techniques; IVF; infertility; ICSI; autistic disorder ID SPECTRUM DISORDERS; UNITED-STATES; PERINATAL RISK; BORN; METHYLATION; PREVALENCE; CONCEPTION; SPERM; INJECTION; OUTCOMES AB STUDY QUESTION: Are assisted reproductive technology (ART) treatment factors or infertility diagnoses associated with autism among ART-conceived children? SUMMARY ANSWER: Our study suggests that the incidence of autism diagnosis in ART-conceived children during the first 5 years of life was higher when intracytoplasmic sperm injection (ICSI) was used compared with conventional IVF, and lower when parents had unexplained infertility (among singletons) or tubal factor infertility (among multiples) compared with other types of infertility. WHAT IS KNOWN ALREADY: Some studies found an increased risk of autism among ART-conceived infants compared with spontaneously-conceived infants. However, few studies, and none in the USA, have examined the associations between types of ART procedures and parental infertility diagnoses with autism among ART-conceived children. STUDY DESIGN, SIZE, DURATION: Population-based retrospective cohort study using linkages between National ART Surveillance System (NASS) data for 1996-2006, California Birth Certificate data for 1997-2006, and California Department of Developmental Services (DDS) Autism Caseload data for 1997-2011. PARTICIPANTS/MATERIALS, SETTING, METHODS: All live born ART-conceived infants born in California in 1997-2006 (n = 42 383) with 5-year observation period were included in the study. We assessed the annual incidence of autism diagnosis documented in DDS, which includes information on the vast majority of persons with autismin California, and the association of autism diagnosis with ART treatment factors and infertility diagnoses. MAIN RESULTS AND THE ROLE OF CHANCE: Among ART-conceived singletons born in California between 1997 and 2006, the incidence of autism diagnosis remained at similar to 0.8% (P for trend 0.19) andwas lower with parental diagnosis of unexplained infertility (adjusted hazard risk ratio [aHRR]; 95% confidence interval: 0.38; 0.15-0.94) and higher when ICSI was used (aHRR 1.65; 1.08-2.52), when compared with cases without these patient and treatment characteristics. Among ART-conceived multiples, the incidence of autism diagnosis between 1997 and 2006 remained at similar to 1.2% (P for trend 0.93) and was lower with parental diagnosis of tubal factor infertility (aHRR 0.56; 0.35-0.90) and higher when ICSI was used (aHRR 1.71; 1.10-2.66). LIMITATIONS, REASONS FOR CAUTION: Study limitations include imperfect data linkages, lack of data on embryo quality and possible underestimation of autism diagnosis cases. Limitations of the observational study design could affect the analysis by the possibility of residual confounders. Since information about ICSI use was missing for most frozen/thawed embryo transfer cycles, our findings of association of ICSI use and autism diagnosis can only be generalizable to fresh embryo transfer cycles. WIDER IMPLICATIONS OF THE FINDINGS: Our study provides additional evidence of the association between some types of ART procedures with autism diagnosis. Additional research is required to explain the increased risk of autism diagnosis with ICSI use, as well as studies on the effectiveness and safety of ICSI. C1 [Kissin, D. M.; Zhang, Y.; Boulet, S. L.; Jamieson, D. J.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Fountain, C.] Fordham Univ, Dept Sociol & Anthropol, New York, NY 10023 USA. [Bearman, P.] Columbia Univ, Interdisciplinary Ctr Innovat Theory & Empir, New York, NY USA. [Schieve, L.; Yeargin-Allsopp, M.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30341 USA. RP Kissin, DM (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, 4770 Buford Highway NE,Mailstop F-74, Atlanta, GA 30341 USA. EM dkissin@cdc.gov FU NIH of the NIH Roadmap for Medical Research [1 DP1 OD003635-01]; National Institutes of Mental Health [R21MH096122] FX This research is partially supported by the NIH Director's Pioneer Award program, part of the NIH Roadmap for Medical Research, through grant number 1 DPI OD003635-01 and the National Institutes of Mental Health award number R21MH096122. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 44 TC 6 Z9 6 U1 3 U2 12 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0268-1161 EI 1460-2350 J9 HUM REPROD JI Hum. Reprod. PD FEB PY 2015 VL 30 IS 2 BP 454 EP 465 DI 10.1093/humrep/deu338 PG 12 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA CC2AK UT WOS:000350146600023 PM 25518976 ER PT J AU Koul, PA Mir, H Bhat, MA Khan, UH Khan, MM Chadha, MS Lal, RB AF Koul, P. A. Mir, H. Bhat, M. A. Khan, U. H. Khan, M. M. Chadha, M. S. Lal, R. B. TI Performance of rapid influenza diagnostic tests (QuickVue) for Influenza A and B Infection in India SO INDIAN JOURNAL OF MEDICAL MICROBIOLOGY LA English DT Article DE Influenza; rapid tests; real-time PCR; sensitivity ID PANDEMIC H1N1 2009; SEASONAL INFLUENZA; CHILDREN; METAANALYSIS; SENSITIVITY; COMMUNITY; ACCURACY; OUTBREAK; KASHMIR; PCR AB Background: Rapid point-of-care (POC) tests provide an economical alternative for rapid diagnosis and treatment of influenza, especially in public health emergency situations. Objectives: To test the performance of a rapid influenza diagnostic test, QuickVue (Quidel) as a POC test against a real-time polymerase chain reaction (RT-PCR) assay for detection of influenza A and B in a developing country setting. Study Design: In a prospective observational design, 600 patients with influenza-like illness (ILI) or with severe acute respiratory illness (SARI) who were referred to the Influenza Clinic of a tertiary care hospital in Srinagar, India from September 2012 to April 2013, were enrolled for diagnostic testing for influenza using QuickVue or RT-PCR. All influenza A-positive patients by RT-PCR were further subtyped using primers and probes for A/H1pdm09 and A/H3. Results: Of the 600 patients, 186 tested positive for influenza A or B by RT-PCR (90 A/H1N1pdm09, 7 A/H3 and 89 influenza B), whereas only 43 tested positive for influenza (influenza A = 22 and influenza B = 21) by QuickVue. Thus, the sensitivity of the QuickVue was only 23% (95% confidence interval, CI: 17.3-29.8) and specificity was 100% (95% CI: 99.1-100) with a positive predictive value (PPV) of 100% (95% CI 91.8-100) and a negative predictive value (NPV) of 74.3% (95% CI: 70.5-77.9) as compared to RT-PCR. Conclusions: The high specificity of QuickVue suggest that this POC test can be a useful tool for patient management or triaging during a public health crisis but a low sensitivity suggests that a negative test result need to be further tested using RT-PCR. C1 [Koul, P. A.; Mir, H.; Bhat, M. A.; Khan, U. H.] Sherikashmir Inst Med Sci, Dept Internal & Pulm Med, Srinagar, Jammu & Kashmir, India. [Koul, P. A.; Mir, H.; Bhat, M. A.; Khan, U. H.] Sherikashmir Inst Med Sci, MSM Project Influenza, Srinagar, Jammu & Kashmir, India. [Khan, M. M.] Max Neeman Int, Dept Clin Res, New Delhi, India. [Chadha, M. S.] Natl Inst Virol, Pune, Maharashtra, India. [Lal, R. B.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Koul, PA (reprint author), Sherikashmir Inst Med Sci, Dept Internal & Pulm Med, Srinagar, Jammu & Kashmir, India. EM parvaizk@gmail.com NR 29 TC 1 Z9 1 U1 0 U2 1 PU MEDKNOW PUBLICATIONS & MEDIA PVT LTD PI MUMBAI PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075, INDIA SN 0255-0857 EI 1998-3646 J9 INDIAN J MED MICROBI JI Indian J. Med. Microbiol. PD FEB PY 2015 VL 33 SU 1 BP S26 EP S31 DI 10.4103/0255-0857.148831 PG 6 WC Immunology SC Immunology GA CB7YE UT WOS:000349843900006 ER PT J AU Sewe, M Rocklov, J Williamson, J Hamel, M Nyaguara, A Odhiambo, F Laserson, K AF Sewe, Maquins Rocklov, Joacim Williamson, John Hamel, Mary Nyaguara, Amek Odhiambo, Frank Laserson, Kayla TI The Association of Weather Variability and Under Five Malaria Mortality in KEMRI/CDC HDSS in Western Kenya 2003 to 2008: A Time Series Analysis SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH LA English DT Article ID ANOPHELES-GAMBIAE; CLIMATE-CHANGE; CHILDREN; TRANSMISSION; ARABIENSIS; RAINFALL; VILLAGE; ANEMIA; AREA AB Malaria is among the leading causes of mortality in the younger under-five group of children zero to four years of age. This study aims at describing the relationship between rainfall and temperature on under-five malaria or anaemia mortality in Kenya Medical Research Institute and United States Centers for Disease Control (KEMRI/CDC) Health and Demographic Surveillance System (HDSS). This study was conducted through the ongoing KEMRI and CDC collaboration. A general additive model with a Poisson link function was fit to model the weekly association of lagged cumulative rainfall and average temperature on malaria/anemia mortality in KEMRI/CDC HDSS for the period 2003 to 2008. A trend function was included in the model to control for time trends and seasonality not explained by weather fluctuations. 95% confidence intervals was presented with estimates. Malaria or anemia mortality was found to be associated with changes in temperature and rainfall in the KEMRI HDSS, with a delay up to 16 weeks. The empirical estimates of associations describe established biological relationships well. This information, and particularly, the strength of the relationships over longer lead times can highlight the possibility of developing a predictive forecast with lead times up to 16 weeks in order to enhance preparedness to high transmission episodes. C1 [Sewe, Maquins; Nyaguara, Amek; Odhiambo, Frank] KEMRI Ctr Global Hlth Res, Kisumu 40100, Kenya. [Sewe, Maquins; Rocklov, Joacim] Umea Univ, Dept Publ Hlth & Clin Med Epidemiol & Global Hlth, SE-90185 Umea, Sweden. [Williamson, John; Hamel, Mary; Laserson, Kayla] Ctr Dis Control & Prevent, Ctr Global Hlth, Atlanta, GA 30333 USA. RP Sewe, M (reprint author), KEMRI Ctr Global Hlth Res, Box 1578, Kisumu 40100, Kenya. EM msewe@kemricdc.org; joacim.rocklov@envmed.umu.se; jow5@cdc.gov; mlh8@cdc.gov; namek@kemricdc.org; fodhiambo@kemricdc.org; kel4@cdc.gov FU INDEPTH Network; FAS, the Swedish Council for Working Life and Social Research [2006-1512] FX We acknowledge the KEMRI/CDC Research and Public Health Collaboration staff in general and HDSS branch in particular. This research was supported by the INDEPTH Network. We thank Yazoume Ye, Rainer Sauerborn, Sari Kovats, David Hondula and Martin Bangha who facilitated at INDEPTH workshops in Nouna, Burkina Faso and Accra, Ghana. This research was partly undertaken within the Umea Centre for Global Health Research at Umea University, with support from FAS, the Swedish Council for Working Life and Social Research (Grant No. 2006-1512). NR 31 TC 2 Z9 2 U1 0 U2 5 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1660-4601 J9 INT J ENV RES PUB HE JI Int. J. Environ. Res. Public Health PD FEB PY 2015 VL 12 IS 2 BP 1983 EP 1997 DI 10.3390/ijerph120201983 PG 15 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA CC2XZ UT WOS:000350209800052 PM 25674784 ER PT J AU Owsley, C McGwin, G Lee, DJ Lam, BL Friedman, DS Gower, EW Haller, JA Hark, LA Saaddine, J AF Owsley, Cynthia McGwin, Gerald, Jr. Lee, David J. Lam, Byron L. Friedman, David S. Gower, Emily W. Haller, Julia A. Hark, Lisa A. Saaddine, Jinan CA Innovative Network Sight INSIGHT TI Diabetes Eye Screening in Urban Settings Serving Minority Populations Detection of Diabetic Retinopathy and Other Ocular Findings Using Telemedicine SO JAMA OPHTHALMOLOGY LA English DT Article ID UNITED-STATES; MEDICATION ADHERENCE; AFRICAN-AMERICANS; CARE PROVIDERS; PREVALENCE; MELLITUS; PROGRAM; VISION; COMPLICATIONS; MANAGEMENT AB IMPORTANCE The use of a nonmydriatic camera for retinal imaging combined with the remote evaluation of images at a telemedicine reading center has been advanced as a strategy for diabetic retinopathy (DR) screening, particularly among patients with diabetes mellitus from ethnic/racial minority populations with low utilization of eye care. OBJECTIVE To examine the rate and types of DR identified through a telemedicine screening program using a nonmydriatic camera, as well as the rate of other ocular findings. DESIGN, SETTING, AND PARTICIPANTS A cross-sectional study (Innovative Network for Sight [INSIGHT]) was conducted at 4 urban clinic or pharmacy settings in the United States serving predominantly ethnic/racial minority and uninsured persons with diabetes. Participants included persons aged 18 years or older who had type 1 or 2 diabetes mellitus and presented to the community-based settings. MAIN OUTCOMES AND MEASURES The percentage of DR detection, including type of DR, and the percentage of detection of other ocular findings. RESULTS A total of 1894 persons participated in the INSIGHT screening program across sites, with 21.7% having DR in at least 1 eye. The most common type of DR was background DR, which was present in 94.1% of all participants with DR. Almost half (44.2%) of the sample screened had ocular findings other than DR; 30.7% of the other ocular findings were cataract. CONCLUSIONS AND RELEVANCE In a DR telemedicine screening program in urban clinic or pharmacy settings in the United States serving predominantly ethnic/racial minority populations, DR was identified on screening in approximately 1 in 5 persons with diabetes. The vast majority of DR was background, indicating high public health potential for intervention in the earliest phases of DR when treatment can prevent vision loss. Other ocular conditions were detected at a high rate, a collateral benefit of DR screening programs that may be underappreciated. C1 [Owsley, Cynthia; McGwin, Gerald, Jr.] Univ Alabama Birmingham, Sch Med, Dept Ophthalmol, Birmingham, AL 35294 USA. [McGwin, Gerald, Jr.] Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA. [Lee, David J.] Univ Miami, Miller Sch Med, Dept Publ Hlth Sci, Miami, FL 33136 USA. [Lam, Byron L.] Univ Miami, Miller Sch Med, Bascom Palmer Eye Inst, Miami, FL 33136 USA. [Friedman, David S.; Gower, Emily W.] Johns Hopkins Sch Med, Dana Ctr Prevent Ophthalmol, Wilmer Eye Inst, Baltimore, MD USA. [Gower, Emily W.] Wake Forest Sch Med, Dept Epidemiol, Winston Salem, NC USA. [Gower, Emily W.] Wake Forest Sch Med, Dept Ophthalmol, Winston Salem, NC USA. [Haller, Julia A.; Hark, Lisa A.] Thomas Jefferson Univ, Wills Eye Hosp, Philadelphia, PA 19107 USA. [Saaddine, Jinan] Ctr Dis Control & Prevent, Div Diabet Translat, Vis Hlth Initiat, Atlanta, GA USA. RP Owsley, C (reprint author), Univ Alabama Birmingham, Sch Med, Dept Ophthalmol, 700 S 18th St,Ste 609, Birmingham, AL 35294 USA. EM owsley@uab.edu FU Centers for Disease Control and Prevention (CDC); Johns Hopkins University; University of Alabama at Birmingham; University of Miami; Wills Eye Hospital [5U58DP002651, 5U58DP002652, 5U58DP002653, 5U58DP002655] FX This research was supported through Centers for Disease Control and Prevention (CDC) cooperative agreements with The Johns Hopkins University, University of Alabama at Birmingham, University of Miami, and Wills Eye Hospital (5U58DP002651, 5U58DP002652, 5U58DP002653, and 5U58DP002655). The grantees received additional support directly from Alcon Research Institute (The Johns Hopkins University), the EyeSight Foundation of Alabama (University of Alabama at Birmingham), Research to Prevent Blindness (University of Alabama at Birmingham), and the Buck Trust (University of Alabama at Birmingham). Nidek provided the cameras and operator training free of charge. NR 59 TC 17 Z9 18 U1 2 U2 15 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6165 EI 2168-6173 J9 JAMA OPHTHALMOL JI JAMA Ophthalmol. PD FEB PY 2015 VL 133 IS 2 BP 174 EP 181 DI 10.1001/jamaophthalmol.2014.4652 PG 8 WC Ophthalmology SC Ophthalmology GA CB5NB UT WOS:000349673100008 PM 25393129 ER PT J AU Ball, B Holland, KM Marshall, KJ Lippy, C Jain, S Souders, K Westby, RP AF Ball, Barbara Holland, Kristin M. Marshall, Khiya J. Lippy, Caroline Jain, Sumati Souders, Kathleen Westby, Ruth P. TI Implementing a Targeted Teen Dating Abuse Prevention Program: Challenges and Successes Experienced by Expect Respect Facilitators SO JOURNAL OF ADOLESCENT HEALTH LA English DT Article DE Program implementation; Support groups; Targeted prevention; School based; Violence; Prevention; Teen dating violence ID AT-RISK YOUTH; VIOLENCE VICTIMIZATION; PROTECTIVE FACTORS; SOCIAL SUPPORT; PERPETRATION; ADOLESCENTS; CONSEQUENCES; ASSOCIATIONS; OUTCOMES AB Purpose: Expect Respect Support Groups (ERSGs) are a targeted 24-week dating abuse prevention program tailored to middle and high school students who have been exposed to violence. As part of a controlled evaluation, this qualitative study was designed to examine facilitators' experiences with program implementation and generate a deeper understanding of factors that enhance or challenge implementation and program outcomes. Methods: Semistructured interviews with Expect Respect Support Group facilitators (three males and four females) were conducted at the midpoint and endpoint of the school year. Interview topics included working within the school system, strategies for establishing a productive group process, and individual and group-level responses to the program. Results: Facilitators indicated that school counselors' awareness of students' exposure to violence increased their ability to refer eligible students. Within a supportive school environment, successful groups harnessed the protective qualities of a positive peer group, supported members in questioning the normalcy of abuse, and provided opportunities for building healthy relationship skills. Challenges resulted from impediments to group cohesion including insufficient referrals, inconsistent attendance, and low levels of school support. Students who were frequently absent and disengaged from school were particularly challenging to engage in a school-based program. Conclusions: This research demonstrates that successful implementation of a targeted school-based dating violence prevention program relies on building school support and awareness of teen dating violence, especially for appropriate identification and referral of at-risk students. High levels of school support enhance the development of a supportive group process and attitudinal and behavioral changes among participants. (C) 2015 Society for Adolescent Health and Medicine. All rights reserved. C1 [Ball, Barbara; Jain, Sumati; Souders, Kathleen] SafePlace, Austin, TX 78760 USA. [Holland, Kristin M.; Marshall, Khiya J.; Lippy, Caroline; Westby, Ruth P.] Ctr Dis Control & Prevent, Div Violence Prevent, Atlanta, GA USA. RP Ball, B (reprint author), SafePlace, POB 19454, Austin, TX 78760 USA. EM bball@safeplace.org FU Centers for Disease Control and Prevention, Division of Violence Prevention [200-2010-34099] FX This study was supported by funding from the Centers for Disease Control and Prevention, Division of Violence Prevention Contract #200-2010-34099. NR 35 TC 4 Z9 4 U1 3 U2 18 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X EI 1879-1972 J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD FEB PY 2015 VL 56 IS 2 SU 2 BP S40 EP S46 DI 10.1016/j.jadohealth.2014.06.021 PG 7 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA CC2AO UT WOS:000350147000008 PM 25620453 ER PT J AU Niolon, PH Vivolo-Kantor, AM Latzman, NE Valle, LA Kuoh, H Burton, T Taylor, BG Tharp, AT AF Niolon, Phyllis Holditch Vivolo-Kantor, Alana M. Latzman, Natasha E. Valle, Linda Anne Kuoh, Henrietta Burton, Tessa Taylor, Bruce G. Tharp, Andra T. TI Prevalence of Teen Dating Violence and Co-occurring Risk Factors Among Middle School Youth in High-Risk Urban Communities SO JOURNAL OF ADOLESCENT HEALTH LA English DT Article DE Teen dating violence; High risk; Middle school; Risk factors ID RANDOMIZED CONTROLLED-TRIAL; BEHAVIOR SURVEILLANCE; PREVENTION PROGRAM; GENDER-DIFFERENCES; UNITED-STATES; PERPETRATION; VICTIMIZATION; ADOLESCENCE; CONFLICT; STUDENTS AB Purpose: This study describes the lifetime prevalence of teen dating violence (TDV) perpetration in a sample of middle school students from high-risk urban communities and examines the relation between TDV and related cognitive and behavioral risk factors. Methods: Surveys were administered to 2,895 middle school students in four U.S. cities; 1,673 students (58%) reported having dated and were included in analyses. The sample was 52.3% female, 48.2% non-Hispanic black/African-American, 38.2% Hispanic, 4.8% non-Hispanic white, and 7.6% other race. Six types of TDV perpetration were assessed: threatening behaviors, verbal/emotional abuse, relational abuse, physical abuse, sexual abuse, and stalking. Results: Of the students who had dated, 77% reported perpetrating verbal/emotional abuse, 32% reported perpetrating physical abuse, 20% reported threatening a partner, 15% reported perpetrating sexual abuse, 13% reported perpetrating relational abuse, and 6% reported stalking. Girls were more likely than boys to report perpetrating threatening behaviors, verbal/emotional abuse, and physical abuse, and boys were more likely to report perpetrating sexual abuse. Involvement in bullying positively predicted perpetration of TDV, albeit, in different ways for boys and girls. Other risk factors differed by sex. For instance, alcohol use and sex initiation predicted multiple forms of TDV perpetration for boys, whereas weapon carrying and emotional symptoms predicted several forms of TDV perpetration for girls. Conclusions: The prevalence of TDV was high in our sample. Important sex differences in rates of perpetration and risk factors emerged. Comprehensive prevention programs that target TDV and related risk factors, such as bullying and other risk factors, seem warranted. Published by Elsevier Inc. on behalf of Society for Adolescent Health and Medicine. C1 [Niolon, Phyllis Holditch; Vivolo-Kantor, Alana M.; Latzman, Natasha E.; Valle, Linda Anne; Kuoh, Henrietta; Burton, Tessa; Tharp, Andra T.] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Div Violence Prevent, Atlanta, GA 30341 USA. [Taylor, Bruce G.] Univ Chicago, NORC, Chicago, IL 60637 USA. RP Niolon, PH (reprint author), Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Div Violence Prevent, 4770 Buford Highway NE,MS-F63, Atlanta, GA 30341 USA. EM PNiolon@cdc.gov FU Alameda County Public Health Department [CE002052]; Baltimore City Health Department [CE002050]; Broward County Health Department [CE002048]; Chicago Department of Public Health [CE002054]; NORC at the University of Chicago [200-2011-40998]; Research Triangle Institute [200-2012-51959]; Ogilvy Public Relations [200-2007-20014/0015] FX The authors acknowledge the participation of students and schools in the Dating Matters initiative. We also would like to acknowledge the contribution of each funded public health department; specifically the Alameda County Public Health Department (CE002052), Baltimore City Health Department (CE002050), Broward County Health Department (CE002048), and Chicago Department of Public Health (CE002054). Lastly, we acknowledge our contractors who manage program implementation and data collection efforts; NORC at the University of Chicago (Co. #: 200-2011-40998), Research Triangle Institute (Co. #: 200-2012-51959), and Ogilvy Public Relations (Co. #: 200-2007-20014/0015). NR 44 TC 16 Z9 16 U1 6 U2 34 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X EI 1879-1972 J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD FEB PY 2015 VL 56 IS 2 SU 2 BP S5 EP S13 DI 10.1016/j.jadohealth.2014.07.019 PG 9 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA CC2AO UT WOS:000350147000003 PM 25620454 ER PT J AU Goldberg, AB Ratzan, SC Jacobson, KL Parker, RM AF Goldberg, Allison B. Ratzan, Scott C. Jacobson, Kara L. Parker, Ruth M. TI Addressing Ebola and Other Outbreaks: A Communication Checklist for Global Health Leaders, Policymakers, and Practitioners SO JOURNAL OF HEALTH COMMUNICATION LA English DT Article C1 [Goldberg, Allison B.; Ratzan, Scott C.] Anheuser Busch InBev, Global Corp Affairs, New York, NY 10177 USA. [Ratzan, Scott C.] Ctr Dis Control & Prevent, Off Infect Dis, Board Sci Counselors, Atlanta, GA USA. [Ratzan, Scott C.] Columbia Univ, Mailman Sch Publ Hlth, Dept Sociomed Sci, New York, NY USA. [Jacobson, Kara L.] Emory Univ, Rollins Sch Publ Hlth, Dept Hlth Policy & Management, Atlanta, GA 30322 USA. [Parker, Ruth M.] Emory Univ, Sch Med, Dept Med, Atlanta, GA USA. RP Goldberg, AB (reprint author), Anheuser Busch InBev, Global Corp Affairs, 250 Pk Ave, New York, NY 10177 USA. EM Allison.Goldberg@ab-inbev.com NR 5 TC 1 Z9 1 U1 2 U2 8 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1081-0730 EI 1087-0415 J9 J HEALTH COMMUN JI J. Health Commun. PD FEB 1 PY 2015 VL 20 IS 2 BP 121 EP 122 DI 10.1080/10810730.2015.1007762 PG 2 WC Communication; Information Science & Library Science SC Communication; Information Science & Library Science GA CC4QS UT WOS:000350338700001 PM 25729894 ER PT J AU Carande-Kulis, V Stevens, JA Florence, CS Beattie, BL Arias, I AF Carande-Kulis, Vilma Stevens, Judy A. Florence, Curtis S. Beattie, Bonita L. Arias, Ileana TI A cost-benefit analysis of three older adult fall prevention interventions SO JOURNAL OF SAFETY RESEARCH LA English DT Article DE Cost; Falls; Elderly; Fall intervention ID RANDOMIZED CONTROLLED-TRIAL; TAI-CHI; INJURIES; PEOPLE; CARE AB Introduction: One out of three persons aged 65 and older falls annually and 20% to 30% of falls result in injury. The purpose of this cost-benefit analysis was to identify community-based fall interventions that were feasible, effective, and provided a positive return on investment (ROI). Methods: A third-party payer perspective was used to determine the costs and benefits of three effective fall interventions. Intervention effectiveness was based on randomized controlled trial results. National data were used to estimate the average annual benefits from averting the direct medical costs of a fall. The net benefit and ROI were estimated for each of the interventions. Results: For the Otago Exercise Program delivered to persons aged 65 and older, the net benefit was $121.85 per participant and the ROI was 36% for each dollar invested. For Otago delivered to persons aged 80 and older, the net benefit was $429.18 and the ROI was 127%. Tai chi: Moving for Better Balance had a net benefit of $529.86 and an ROI of 509% and Stepping On had a net benefit of $134.37 and an ROI of 64%. Conclusions: All three fall interventions provided positive net benefits. The ROIs showed that the benefits not only covered the implementation costs but also exceeded the expected direct program delivery costs. These results can help health care hinders and other community organizations select appropriate and effective fall interventions that also can provide positive returns on investment. (C) 2015 National Safety Council and Elsevier Ltd. All rights reserved. C1 [Carande-Kulis, Vilma] Ctr Dis Control & Prevent, Off Associate Director Sci, Atlanta, GA 30333 USA. [Stevens, Judy A.; Florence, Curtis S.] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA. [Beattie, Bonita L.] Natl Council Aging, Washington, DC 20036 USA. [Arias, Ileana] Ctr Dis Control & Prevent, Off Director, Atlanta, GA 30333 USA. RP Stevens, JA (reprint author), Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, 4770 Buford Highway NE,Mailstop F-62, Atlanta, GA 30341 USA. EM jas2@cdc.gov NR 15 TC 16 Z9 16 U1 5 U2 19 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4375 EI 1879-1247 J9 J SAFETY RES JI J. Saf. Res. PD FEB PY 2015 VL 52 BP 65 EP 70 DI 10.1016/j.jsr.2014.12.007 PG 6 WC Ergonomics; Public, Environmental & Occupational Health; Social Sciences, Interdisciplinary; Transportation SC Engineering; Public, Environmental & Occupational Health; Social Sciences - Other Topics; Transportation GA CC1CE UT WOS:000350078000009 PM 25662884 ER PT J AU Muehlenbachs, A Bollweg, B Schulz, T Gregory, R Cummings, P Andrew, T Prial, M Prahlow, J Ritter, J Ng, D Sanders, J Forrester, J Zaki, S AF Muehlenbachs, Atis Bollweg, Brigid Schulz, Thadeus Gregory, Ray Cummings, Peter Andrew, Thomas Prial, Margaret Prahlow, Joseph Ritter, Jana Ng, Dianna Sanders, Jeanine Forrester, Joseph Zaki, Sherif TI Lyme Carditis: Autopsy Findings of 5 Patients With Sudden Cardiac Death SO MODERN PATHOLOGY LA English DT Meeting Abstract CT 104th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology CY MAR 21-27, 2015 CL Boston, MA SP US & Canadian Acad Pathol C1 Ctr Dis Control & Prevent, Atlanta, GA USA. CryoLife, Kennesaw, GA USA. Off Chief Med Examiner, Boston, MA USA. Off Chief Med Examiner, Concord, NH USA. Off Med Examiner, Orange County, NY USA. Med Fdn, South Bend, IN USA. Indiana Univ Sch Med South Bend, South Bend, IN USA. Ctr Dis Control & Prevent, Ft Collins, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0893-3952 EI 1530-0285 J9 MODERN PATHOL JI Mod. Pathol. PD FEB PY 2015 VL 28 SU 2 MA 1569 BP 394A EP 394A PG 1 WC Pathology SC Pathology GA CB3BF UT WOS:000349502202278 ER PT J AU Ng, D Sanders, J Zaki, S Shieh, WJ AF Ng, Dianna Sanders, Jeanine Zaki, Sherif Shieh, Wun-Ju TI Grocott Methenamine Silver Stain: An Adjunct Diagnostic Tool in the Identification of Bacteria in Tissues SO MODERN PATHOLOGY LA English DT Meeting Abstract CT 104th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology CY MAR 21-27, 2015 CL Boston, MA SP US & Canadian Acad Pathol C1 [Ng, Dianna; Sanders, Jeanine; Zaki, Sherif; Shieh, Wun-Ju] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0893-3952 EI 1530-0285 J9 MODERN PATHOL JI Mod. Pathol. PD FEB PY 2015 VL 28 SU 2 MA 1571 BP 394A EP 394A PG 1 WC Pathology SC Pathology GA CB3BF UT WOS:000349502202280 ER PT J AU Wan, HQ Yang, H Shore, DA Garten, RJ Couzens, L Gao, J Jiang, LL Carney, PJ Villanueva, J Stevens, J Eichelberger, MC AF Wan, Hongquan Yang, Hua Shore, David A. Garten, Rebecca J. Couzens, Laura Gao, Jin Jiang, Lianlian Carney, Paul J. Villanueva, Julie Stevens, James Eichelberger, Maryna C. TI Structural characterization of a protective epitope spanning A(H1N1)pdm09 influenza virus neuraminidase monomers SO NATURE COMMUNICATIONS LA English DT Article ID PANDEMIC H1N1 NEURAMINIDASE; MONOCLONAL-ANTIBODY; 3-DIMENSIONAL STRUCTURE; UNITED-STATES; A VIRUSES; COMPLEX; THERAPY; HEMAGGLUTININ; 150-CAVITY; LIKELIHOOD AB A(H1N1)pdm09 influenza A viruses predominated in the 2013-2014 USA influenza season, and although most of these viruses remain sensitive to Food and Drug Administration-approved neuraminidase (NA) inhibitors, alternative therapies are needed. Here we show that monoclonal antibody CD6, selected for binding to the NA of the prototypic A(H1N1) pdm09 virus, A/California/07/2009, protects mice against lethal virus challenge. The crystal structure of NA in complex with CD6 Fab reveals a unique epitope, where the heavy-chain complementarity determining regions (HCDRs) 1 and 2 bind one NA monomer, the light-chain CDR2 binds the neighbouring monomer, whereas HCDR3 interacts with both monomers. This 30-amino-acid epitope spans the lateral face of an NA dimer and is conserved among circulating A(H1N1) pdm09 viruses. These results suggest that the large, lateral CD6 epitope may be an effective target of antibodies selected for development as therapeutic agents against circulating H1N1 influenza viruses. C1 [Wan, Hongquan; Couzens, Laura; Gao, Jin; Jiang, Lianlian; Eichelberger, Maryna C.] Ctr Biol Evaluat & Res Food & Drug Adm, Div Viral Prod, Silver Spring, MD 20993 USA. [Yang, Hua; Shore, David A.; Garten, Rebecca J.; Carney, Paul J.; Villanueva, Julie; Stevens, James] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Influenza Div, Atlanta, GA 30333 USA. RP Stevens, J (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Influenza Div, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM James.Stevens@cdc.hhs.gov; Maryna.Eichelberger@fda.hhs.gov FU Food and Drug Administration; Centers for Disease Control and Prevention; US Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-06CH11357] FX This work was funded by the Food and Drug Administration and the Centers for Disease Control and Prevention. We thank Drs J. Taubenberger and M. Memoli (National Institute of Health, Bethesda, MD, USA) for providing the pCAGGS-CA/09NA plasmid and drug-resistant virus, and Dr R. Webster (St Jude Children's Research Hospital, Memphis, TN, USA) for providing plasmids used to generate influenza viruses by reverse genetics. Dr L. Jiang was supported by training funds administered by the Oak Ridge Institute for Science and Education. We are indebted to staff of the Division of Veterinary Services, Center for Biologics Evaluation and Research, Food and Drug Administration, for excellent animal care. We thank the WHO Global Influenza Surveillance and Response System (GISRS) for providing the virus sequences used to generate the NA expression clones described here, as well as all submitting laboratories, which have deposited their pH1N1 NA sequences to the GISAID Epiflu database (http://www.gisaid.org). Use of the Advanced Photon Source at Argonne National Laboratory was supported by the US Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357. We thank the staff of SER-CAT sector 22 for their help with data collection. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Food and Drug Administration, the Centers for Disease Control and Prevention or the Agency for Toxic Substances and Disease Registry. NR 53 TC 8 Z9 8 U1 2 U2 10 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2041-1723 J9 NAT COMMUN JI Nat. Commun. PD FEB PY 2015 VL 6 AR 6114 DI 10.1038/ncomms7114 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CC2TJ UT WOS:000350197200002 PM 25668439 ER PT J AU Walter, EB Kemper, AR Dolor, RJ Dunne, EF AF Walter, Emmanuel B. Kemper, Alex R. Dolor, Rowena J. Dunne, Eileen F. TI Pain in Adolescent Girls Receiving Human Papillomavirus Vaccine With Concomitantly Administered Vaccines SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE human papillomavirus; vaccine; pain ID INJECTION; SCALE AB Using the Faces Pain Scale - Revised, we assessed injection site pain 10 minutes after vaccination in young females randomized to receive either quadrivalent human papillomavirus vaccine (HPV4) before or after concomitantly administered vaccines. Although pain was modestly more after HPV4 injection than after other vaccines, the pain intensity after HPV4 injection was significantly less in those who received HPV4 before receiving other concomitant vaccines. C1 [Walter, Emmanuel B.; Kemper, Alex R.; Dolor, Rowena J.] Duke Univ Sch Med, Clin Vaccine Unit, Durham, NC USA. [Walter, Emmanuel B.; Kemper, Alex R.; Dolor, Rowena J.] Duke Univ Sch Med, Primary Care Res Consortium, Durham, NC USA. [Dunne, Eileen F.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA USA. RP Walter, EB (reprint author), Duke Childrens Primary Care, 4020 North Roxboro St, Durham, NC 27704 USA. EM walte002@mc.duke.edu FU Duke University School of Medicine [5U36CD319276]; AAMC-CDC [5U36CD319276] FX This work was supported by a cooperative agreement between Duke University School of Medicine and AAMC-CDC: #5U36CD319276. NR 9 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0891-3668 EI 1532-0987 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD FEB PY 2015 VL 34 IS 2 BP 200 EP 202 DI 10.1097/INF.0000000000000537 PG 3 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA CB8VE UT WOS:000349908800018 PM 25170553 ER PT J AU Logan, JE Skopp, NA Reger, MA Gladden, M Smolenski, DJ Floyd, CF Gahm, GA AF Logan, Joseph E. Skopp, Nancy A. Reger, Mark A. Gladden, Matt Smolenski, Derek J. Floyd, C. Faye Gahm, Gregory A. TI Precipitating Circumstances of Suicide among Active Duty US Army Personnel Versus US Civilians, 2005-2010 SO SUICIDE AND LIFE-THREATENING BEHAVIOR LA English DT Article ID DEATH REPORTING SYSTEM; RISK-FACTORS; VIOLENT DEATHS; 16 STATES; MILITARY; SURVEILLANCE; POPULATION; MORTALITY; VETERANS AB To help understand suicide among soldiers, we compared suicide events between active duty U.S. Army versus civilian decedents to identify differences and inform military prevention efforts. We linked 141 Army suicide records from 2005 to 2010 to National Violent Death Reporting System (NVDRS) data. We described the decedents' military background and compared their precipitators of death captured in NVDRS to those of demographically matched civilian suicide decedents. Both groups commonly had mental health and intimate partner precipitating circumstances, but soldier decedents less commonly disclosed suicide intent. C1 [Logan, Joseph E.; Gladden, Matt; Floyd, C. Faye] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA. [Skopp, Nancy A.; Reger, Mark A.; Smolenski, Derek J.; Gahm, Gregory A.] US Dept Def, Natl Ctr Telehlth & Technol, Joint Base Lewis McChord, Tacoma, WA USA. RP Logan, JE (reprint author), Ctr Dis Control & Prevent, Div Violence Prevent, Res & Evaluat Branch, 4770 Buford Highway,MS-F63, Atlanta, GA 30341 USA. EM ffa3@cdc.gov FU Centers for Disease Control and Prevention; National Center for Telehealth and Technology FX Funding was provided by the Centers for Disease Control and Prevention and the National Center for Telehealth and Technology. NR 31 TC 5 Z9 5 U1 1 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0363-0234 EI 1943-278X J9 SUICIDE LIFE-THREAT JI Suicide Life-Threat. Behav. PD FEB PY 2015 VL 45 IS 1 BP 65 EP 77 DI 10.1111/sltb.12111 PG 13 WC Psychiatry; Psychology, Multidisciplinary SC Psychiatry; Psychology GA CC0BA UT WOS:000349998700007 PM 25093259 ER PT J AU Che-Mendoza, A Guillermo-May, G Herrera-Bojorquez, J Barrera-Perez, M Dzul-Manzanilla, F Gutierrez-Castro, C Arredondo-Jimenez, JI Sanchez-Tejeda, G Vazquez-Prokopec, G Ranson, H Lenhart, A Sommerfeld, J McCall, PJ Kroeger, A Manrique-Saide, P AF Che-Mendoza, Azael Guillermo-May, Guillermo Herrera-Bojorquez, Josue Barrera-Perez, Mario Dzul-Manzanilla, Felipe Gutierrez-Castro, Cipriano Arredondo-Jimenez, Juan I. Sanchez-Tejeda, Gustavo Vazquez-Prokopec, Gonzalo Ranson, Hilary Lenhart, Audrey Sommerfeld, Johannes McCall, Philip J. Kroeger, Axel Manrique-Saide, Pablo TI Long-lasting insecticide-treated house screens and targeted treatment of productive breeding-sites for dengue vector control in Acapulco, Mexico SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article DE Aedes aegypti; Control; Dengue; LLIS; Mexico; Targeted treatment ID CLUSTER-RANDOMIZED-TRIAL; WATER CONTAINER COVERS; MALARIA VECTORS; AEDES-AEGYPTI; MULTICOUNTRY; CURTAINS; MOSQUITOS; EXPOSURE; THAILAND; GAMBIA AB Background: Long-lasting insecticidal net screens (LLIS) fitted to domestic windows and doors in combination with targeted treatment (TT) of the most productive Aedes aegypti breeding sites were evaluated for their impact on dengue vector indices in a cluster-randomised trial in Mexico between 2011 and 2013. Methods: Sequentially over 2 years, LLIS and TT were deployed in 10 treatment clusters (100 houses/cluster) and followed up over 24 months. Cross-sectional surveys quantified infestations of adult mosquitoes, immature stages at baseline (pre-intervention) and in four post-intervention samples at 6-monthly intervals. Identical surveys were carried out in 10 control clusters that received no treatment. Results: LLIS clusters had significantly lower infestations compared to control clusters at 5 and 12 months after installation, as measured by adult (male and female) and pupal-based vector indices. After addition of TT to the intervention houses in intervention clusters, indices remained significantly lower in the treated clusters until 18 (immature and adult stage indices) and 24 months (adult indices only) post-intervention. Conclusions: These safe, simple affordable vector control tools were well-accepted by study participants and are potentially suitable in many regions at risk from dengue worldwide. C1 [Che-Mendoza, Azael] Gobierno Estado Yucatan, Serv Salud Yucatan, Merida 97000, Mexico. [Guillermo-May, Guillermo; Herrera-Bojorquez, Josue; Barrera-Perez, Mario; Manrique-Saide, Pablo] Univ Autonoma Yucatan, Merida 97000, Mexico. [Dzul-Manzanilla, Felipe; Gutierrez-Castro, Cipriano] Serv Estatales Salud Guerrero, Chilpancingo 39090, Mexico. [Arredondo-Jimenez, Juan I.; Sanchez-Tejeda, Gustavo] Secretaria Salud Mexico, Ctr Nacl Programas Prevent & Control Enfermedades, Mexico City, DF, Mexico. [Ranson, Hilary; McCall, Philip J.] Univ Liverpool, Liverpool Sch Trop Med, Vector Biol Dept, Liverpool L3 5QA, Merseyside, England. [Vazquez-Prokopec, Gonzalo] Emory Univ, Dept Environm Sci, Atlanta, GA 30322 USA. [Lenhart, Audrey] US Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. [Sommerfeld, Johannes; Kroeger, Axel] WHO, Special Programme Res & Training Trop Dis TDR, CH-1211 Geneva 27, Switzerland. RP Manrique-Saide, P (reprint author), Univ Autonoma Yucatan, Unidad Colaborat Bioensayos Entomol, Dept Zool, Campus Ciencias Biol & Agr, Merida 97315, Mexico. EM pablo_manrique2000@hotmail.com OI Kroeger, Axel/0000-0001-8438-2904; Ranson, Hilary/0000-0003-2332-8247 FU UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR); International Development Research Centre (IDRC), Ottawa, Canada; FOMIX CONACYT-Guerrero [GUE-2008-02-108686] FX This investigation received financial support from the UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR) with the aid of a grant from the International Development Research Centre (IDRC), Ottawa, Canada. We also thank FOMIX CONACYT-Guerrero for the financial support of the Project 'Control Integrado de Aedes aegypti con estrategias y herramientas innovadoras en una zona de alto riesgo para la transmision del dengue en Guerrero, Mexico' (Project GUE-2008-02-108686). NR 29 TC 9 Z9 9 U1 2 U2 6 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0035-9203 EI 1878-3503 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD FEB PY 2015 VL 109 IS 2 BP 106 EP 115 DI 10.1093/trstmh/tru189 PG 10 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA CC1LT UT WOS:000350102900005 PM 25604761 ER PT J AU Albarino, CG Guerrero, LW Spengler, JR Uebelhoer, LS Chakrabarti, AK Nichol, ST Towner, JS AF Albarino, Cesar G. Guerrero, Lisa Wiggleton Spengler, Jessica R. Uebelhoer, Luke S. Chakrabarti, Ayan K. Nichol, Stuart T. Towner, Jonathan S. TI Recombinant Marburg viruses containing mutations in the IID region of VP35 prevent inhibition of Host immune responses SO VIROLOGY LA English DT Article DE Filovirus; Marburg virus; Bat virus; VP35; IFN-antagonism; Central basic; Patch; Immune-modulatory; Ebola virus ID DOUBLE-STRANDED-RNA; ZAIRE EBOLAVIRUS VP35; INTERFERON ANTAGONISM; HEMORRHAGIC-FEVER; RIG-I; EVASION MECHANISMS; IRF-3 ACTIVATION; STRUCTURAL BASIS; GUINEA-PIGS; PROTEIN AB Previous in vitro studies have demonstrated that Ebola and Marburg virus (EBOV and MARV) VP35 antagonize the host cell immune response. Moreover, specific mutations in the IFN inhibitory domain (IID) of EBOV and MARV VP35 that abrogate their interaction with virus-derived dsRNA, lack the ability to inhibit the host immune response. To investigate the role of MARV VP35 in the context of infectious virus, we used our reverse genetics system to generate two recombinant MARVs carrying specific mutations in the IID region of VP35. Our data show that wild-type and mutant viruses grow to similar titers in interferon deficient cells, but exhibit attenuated growth in interferon-competent cells. Furthermore, in contrast to wild-type virus, both MARV mutants were unable to inhibit expression of various antiviral genes. The MARV VP35 mutants exhibit similar phenotypes to those previously described for EBOV, suggesting the existence of a shared immune-modulatory strategy between filoviruses. Published by Elsevier Inc. C1 [Albarino, Cesar G.; Guerrero, Lisa Wiggleton; Spengler, Jessica R.; Uebelhoer, Luke S.; Chakrabarti, Ayan K.; Nichol, Stuart T.; Towner, Jonathan S.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Towner, JS (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. EM jit8@cdc.gov OI Spengler, Jessica R./0000-0002-5383-0513 NR 38 TC 7 Z9 7 U1 2 U2 7 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD FEB PY 2015 VL 476 BP 85 EP 91 DI 10.1016/j.virol.2014.12.002 PG 7 WC Virology SC Virology GA CB8MF UT WOS:000349883000010 PM 25531184 ER PT J AU Pantazides, BG Crow, BS Garton, JW Quinones-Gonzalez, JA Blake, TA Thomas, JD Johnson, RC AF Pantazides, Brooke G. Crow, Brian S. Garton, Joshua W. Quinones-Gonzalez, Jennifer A. Blake, Thomas A. Thomas, Jerry D. Johnson, Rudolph C. TI Simplified Method for Quantifying Sulfur Mustard Adducts to Blood Proteins by Ultrahigh Pressure Liquid Chromatography Isotope Dilution Tandem Mass Spectrometry SO CHEMICAL RESEARCH IN TOXICOLOGY LA English DT Article ID QUALITY-CONTROL; EXPOSURE; METABOLITES; IDENTIFICATION; QUANTITATION; HEMOGLOBIN; CASUALTIES; URINE; ASSAY AB Sulfur mustard binds to reactive cysteine residues, forming a stable sulfur-hydroxyethylthioethyl [S-HETE] adduct that can be used as a long-term biomarker of sulfur mustard exposure in humans. The digestion of sulfur mustard-exposed blood samples with proteinase K following total protein precipitation with acetone produces the tripeptide biomarker [S-HETE]-Cys-Pro-Phe. The adducted tripeptide is purified by solid phase extraction, separated by ultrahigh pressure liquid chromatography, and detected by isotope dilution tandem mass spectrometry. This approach was thoroughly validated and characterized in our laboratory. The average interday relative standard deviation was <= 9.49%, and the range of accuracy was between 96.1 and 109% over a concentration range of 3.00 to 250. ng/mL with a calculated limit of detection of 1.74 ng/mL. A full 96-well plate can be processed and analyzed in 8 h, which is 5 times faster than our previous 96-well plate method and only requires 50 mu L of serum, plasma, or whole blood. Extensive ruggedness and stability studies and matrix comparisons were conducted to create a robust, easily transferrable method. As a result, a simple and high-throughput method has been developed and validated for the quantitation of sulfur mustard blood protein adducts in low volume blood specimens which should be readily adaptable for quantifying human exposures to other alkylating agents. C1 [Pantazides, Brooke G.; Crow, Brian S.; Garton, Joshua W.; Quinones-Gonzalez, Jennifer A.; Blake, Thomas A.; Thomas, Jerry D.; Johnson, Rudolph C.] Ctr Dis Control & Prevent, Emergency Response Branch, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. RP Pantazides, BG (reprint author), Ctr Dis Control & Prevent, Emergency Response Branch, Div Sci Lab, Natl Ctr Environm Hlth, 4770 Buford Highway NE, Atlanta, GA 30341 USA. EM WLX3@cdc.gov OI Garton, Joshua/0000-0002-4549-1224; Blake, Thomas/0000-0001-8536-9998 FU Centers for Disease Control and Prevention; Office of Public Health Preparedness and Response; Oak Ridge Institute for Science, and Education; Defense Threat Reduction Agency [11-005-12430] FX This work was supported by the Centers for Disease Control and Prevention, Office of Public Health Preparedness and Response, the Oak Ridge Institute for Science, and Education, and the Defense Threat Reduction Agency (11-005-12430). NR 29 TC 7 Z9 7 U1 3 U2 20 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0893-228X EI 1520-5010 J9 CHEM RES TOXICOL JI Chem. Res. Toxicol. PD FEB PY 2015 VL 28 IS 2 BP 256 EP 261 DI 10.1021/tx500468h PG 6 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology SC Pharmacology & Pharmacy; Chemistry; Toxicology GA CB5GS UT WOS:000349656100012 PM 25622494 ER PT J AU Cooley, LA Wejnert, C Rose, CE Paz-Bailey, G AF Cooley, Laura A. Wejnert, Cyprian Rose, Charles E. Paz-Bailey, Gabriela CA Natl HIV Behav Surveillance Study TI Increases in Recent HIV Testing Among Men Who Have Sex With Men Coincide With the Centers for Disease Control and Prevention's Expanded Testing Initiative SO CLINICAL INFECTIOUS DISEASES LA English DT Editorial Material DE MSM; HIV; diagnosis; African Americans; prevention and control ID UNITED-STATES; PERSONS AWARE; RISK; BEHAVIOR; UNAWARE AB According to National HIV Behavioral Surveillance system data, human immunodeficiency virus (HIV) testing increased among gay, bisexual, and other men who have sex with men from 2008 to 2011 in cities funded by the Centers for Disease Control and Prevention's Expanded Testing Initiative, suggesting that focused HIV testing initiatives might have positive effects. C1 [Cooley, Laura A.; Wejnert, Cyprian; Rose, Charles E.; Paz-Bailey, Gabriela; Natl HIV Behav Surveillance Study] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA 30329 USA. RP Cooley, LA (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, 1600 Clifton Rd NE,MS-E46, Atlanta, GA 30329 USA. EM lcooley@cdc.gov FU NIAID NIH HHS [P30 AI073961] NR 11 TC 6 Z9 6 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD FEB 1 PY 2015 VL 60 IS 3 BP 483 EP 485 DI 10.1093/cid/ciu851 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CB6UG UT WOS:000349761600030 PM 25352589 ER PT J AU Flamme, GA Geda, K McGregor, KD Wyllys, K Deiters, KK Murphy, WJ Stephenson, MR AF Flamme, Gregory A. Geda, Kyle McGregor, Kara D. Wyllys, Krista Deiters, Kristy K. Murphy, William J. Stephenson, Mark R. TI Stimulus and transducer effects on threshold SO INTERNATIONAL JOURNAL OF AUDIOLOGY LA English DT Article DE Audiometry; noise-induced hearing loss; reliability; occupational health AB Objective: This study examined differences in thresholds obtained under Sennheiser HDA200 circumaural earphones using pure tone, equivalent rectangular noise bands, and 1/3 octave noise bands relative to thresholds obtained using Telephonics TDH-39P supra-aural earphones. Design: Thresholds were obtained via each transducer and stimulus condition six times within a 10-day period. Study sample: Forty-nine adults were selected from a prior study to represent low, moderate, and high threshold reliability. Results: The results suggested that (1) only small adjustments were needed to reach equivalent TDH-39P thresholds, (2) pure-tone thresholds obtained with HDA200 circumaural earphones had reliability equal to or better than those obtained using TDH-39P earphones, (3) the reliability of noise-band thresholds improved with broader stimulus bandwidth and was either equal to or better than pure-tone thresholds, and (4) frequency-specifi city declined with stimulus bandwidths greater than one equivalent rectangular band, which could complicate early detection of hearing changes that occur within a narrow frequency range. Conclusions: These data suggest that circumaural earphones such as the HDA200 headphones provide better reliability for audiometric testing as compared to the TDH-39P earphones. These data support the use of noise bands, preferably ERB noises, as stimuli for audiometric monitoring. C1 [Flamme, Gregory A.; Geda, Kyle; McGregor, Kara D.; Wyllys, Krista; Deiters, Kristy K.] Western Michigan Univ, Dept Speech Pathol & Audiol, Kalamazoo, MI 49008 USA. [Murphy, William J.; Stephenson, Mark R.] NIOSH, Div Appl Res & Technol, Cincinnati, OH 45226 USA. RP Flamme, GA (reprint author), Western Michigan Univ, Dept Speech Pathol & Audiol, 1903 W Michigan Ave, Kalamazoo, MI 49008 USA. EM greg.flamme@wmich.edu FU CDC/NIOSH [254-2011-M-40487] FX This study was supported by CDC/NIOSH Contract number 254-2011-M-40487. We also acknowledge the contributions of Amanda Hessenauer and Devon VanGessel, who helped develop the parent study procedures that were modified for use in this study. The data from this manuscript and the associated analyses were presented at the National Hearing Conservation Association meeting held in Las Vegas in March 2014. A detailed contractor report was provided to the National Institute for Occupational Safety and Health and is available upon request. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of Centers for Disease Control and Prevention (CDC) or the National Institute for Occupational Safety and Health (NIOSH). Mention of any company or product does not constitute endorsement by CDC or NIOSH. NR 11 TC 1 Z9 1 U1 0 U2 1 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1499-2027 EI 1708-8186 J9 INT J AUDIOL JI Int. J. Audiol. PD FEB PY 2015 VL 54 SU 1 BP S19 EP S29 DI 10.3109/14992027.2014.979300 PG 11 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA CB5MF UT WOS:000349670800004 PM 25549164 ER PT J AU Murphy, WJ Grantham, MAM AF Murphy, William J. Grantham, Marjorie A. M. TI Stop gambling with your hearing Foreword SO INTERNATIONAL JOURNAL OF AUDIOLOGY LA English DT Editorial Material DE Hearing loss prevention; hearing conservation; hearing protection; speech intelligibility; noise C1 [Murphy, William J.] NIOSH, Cincinnati, OH 45226 USA. [Grantham, Marjorie A. M.] Carl R Darnall Army Med Ctr, Dept Prevent Med, Ft Hood, TX USA. RP Murphy, WJ (reprint author), NIOSH, 1150 Tusculum Ave,Mailstop C-27, Cincinnati, OH 45226 USA. EM wjm4@cdc.gov FU Intramural CDC HHS [CC999999] NR 0 TC 0 Z9 0 U1 1 U2 2 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1499-2027 EI 1708-8186 J9 INT J AUDIOL JI Int. J. Audiol. PD FEB PY 2015 VL 54 SU 1 BP S1 EP S2 DI 10.3109/14992027.2014.980522 PG 2 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA CB5MF UT WOS:000349670800001 PM 25530043 ER PT J AU Zablotsky, B Pringle, BA Colpe, LJ Kogan, MD Rice, C Blumberg, SJ AF Zablotsky, Benjamin Pringle, Beverly A. Colpe, Lisa J. Kogan, Michael D. Rice, Catherine Blumberg, Stephen J. TI Service and Treatment Use Among Children Diagnosed With Autism Spectrum Disorders SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS LA English DT Article DE autism spectrum disorder; intellectual disability; national surveys ID PSYCHOTROPIC MEDICATION USE; INTELLECTUAL DISABILITY; CARE NEEDS; HEALTH; EXPENDITURES; PREVALENCE; ACCESS; EXPERIENCES; FAMILIES; SAMPLE AB Objective: Children diagnosed with autism spectrum disorder (ASD) require substantial support to address not only core ASD symptoms but also a range of co-occurring conditions. This study explores treatment and service use among children with ASD with and without intellectual disability (ID) and parents' perception of unmet needs from these treatments. Methods: Data were retrieved from a probability-based national sample of 2077 children diagnosed with ASD, ID, or both (ASD and ID). Weighted multivariate logistic regressions examined differences between diagnostic groups for current medication and service utilization with a subanalysis exploring differences among those with co-occurring psychiatric conditions. Additional modeling examined parents' perception of unmet needs. Results: Children diagnosed with ASD and ID were significantly more likely to be receiving current medication and services when compared with children with ID only or ASD only. Children with a co-occurring psychiatric diagnosis, from all 3 diagnostic groups, were more likely to be receiving a current medication, but not more likely to be receiving a current service when compared with children without a co-occurring psychiatric diagnosis. Children with ASD and a co-occurring psychiatric diagnosis were significantly more likely to have parents who reported unmet needs when compared with parents of children with ASD without a co-occurring psychiatric diagnosis. Conclusions: Children diagnosed with ASD and ID, especially those with a comorbid psychiatric condition, represent a vulnerable population with substantial rates of current service (98%) and medication (67%) usage, but despite these high rates, approximately 30% of parents report that their child's developmental needs are still not being met by their current treatment and services. C1 [Zablotsky, Benjamin; Blumberg, Stephen J.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Pringle, Beverly A.] NIMH, Off Res Dispar & Global Mental Hlth, Bethesda, MD 20892 USA. [Colpe, Lisa J.] NIMH, Div Serv & Intervent Res, Bethesda, MD 20892 USA. [Kogan, Michael D.] Maternal & Child Hlth Bur, Off Epidemiol & Res, Rockville, MD USA. [Rice, Catherine] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. RP Zablotsky, B (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, 3311 Toledo Rd,Room 2118, Hyattsville, MD 20782 USA. EM bzablotsky@cdc.gov RI Rice, Catherine/D-6305-2016 FU Intramural CDC HHS [CC999999] NR 38 TC 6 Z9 6 U1 0 U2 19 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0196-206X EI 1536-7312 J9 J DEV BEHAV PEDIATR JI J. Dev. Behav. Pediatr. PD FEB-MAR PY 2015 VL 36 IS 2 BP 98 EP 105 PG 8 WC Behavioral Sciences; Psychology, Developmental; Pediatrics SC Behavioral Sciences; Psychology; Pediatrics GA CB2HO UT WOS:000349448000074 PM 25650952 ER PT J AU Anixt, JS Bowers, KA Peacock, G Lipkin, P AF Anixt, Julia S. Bowers, Katherine A. Peacock, Georgina Lipkin, Paul TI Prevalence of Co-Occurring Autism Spectrum Disorder and Other Developmental Disorders Among Children With Heart Conditions SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS LA English DT Meeting Abstract C1 [Anixt, Julia S.; Bowers, Katherine A.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA. [Peacock, Georgina] Ctr Dis Control & Prevent, Atlanta, GA USA. [Lipkin, Paul] Kennedy Krieger Inst, Baltimore, MD USA. [Lipkin, Paul] Johns Hopkins Univ, Baltimore, MD USA. RI Bowers, Katherine/N-5226-2015 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0196-206X EI 1536-7312 J9 J DEV BEHAV PEDIATR JI J. Dev. Behav. Pediatr. PD FEB-MAR PY 2015 VL 36 IS 2 MA 43 BP S11 EP S11 PG 1 WC Behavioral Sciences; Psychology, Developmental; Pediatrics SC Behavioral Sciences; Psychology; Pediatrics GA CB2HO UT WOS:000349448000039 ER PT J AU Visser, SN Danielson, ML Claussen, AH Perou, R AF Visser, Susanna N. Danielson, Melissa L. Claussen, Angelika H. Perou, Ruth TI Regional Estimates of ADHD Diagnosis and Treatment Among US Preschoolers SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS LA English DT Meeting Abstract C1 [Visser, Susanna N.; Danielson, Melissa L.; Claussen, Angelika H.; Perou, Ruth] CDC, Off Director, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0196-206X EI 1536-7312 J9 J DEV BEHAV PEDIATR JI J. Dev. Behav. Pediatr. PD FEB-MAR PY 2015 VL 36 IS 2 MA 2 BP S1 EP S1 PG 1 WC Behavioral Sciences; Psychology, Developmental; Pediatrics SC Behavioral Sciences; Psychology; Pediatrics GA CB2HO UT WOS:000349448000003 ER PT J AU Birdsey, J Sieber, WK Chen, GX Hitchcock, EM Lincoln, JE Nakata, A Robinson, CF Sweeney, MH AF Birdsey, Jan Sieber, W. Karl Chen, Guang X. Hitchcock, Edward M. Lincoln, Jennifer E. Nakata, Akinori Robinson, Cynthia F. Sweeney, Marie H. TI National Survey of US Long-Haul Truck Driver Health and Injury Health Behaviors SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID DIESEL EXHAUST EXPOSURE; LUNG-CANCER; PROFESSIONAL DRIVERS; BLADDER-CANCER; UNITED-STATES; RISK-FACTORS; INDUSTRY; POPULATION; METAANALYSIS; PREDICTORS AB Objective: To compare selected health behaviors and body mass index (modifiable risk factors) of US long-haul truck drivers to the US working population by sex. Methods: The National Survey of US Long-Haul Truck Driver Health and Injury interviewed a nationally representative sample of long-haul truck drivers (n = 1265) at truck stops. Age-adjusted results were compared with national health surveys. Results: Compared with US workers, drivers had significantly higher body mass index, current cigarette use, and pack-years of smoking; lower prevalence of annual influenza vaccination; and generally lower alcohol consumption. Physical activity level was low for most drivers, and 25% had never had their cholesterol levels tested. Conclusions: Working conditions common to long-haul trucking may create significant barriers to certain healthy behaviors; thus, transportation and health professionals should address the unique work environment when developing interventions for long-haul drivers. C1 [Birdsey, Jan; Sieber, W. Karl; Robinson, Cynthia F.; Sweeney, Marie H.] Ctr Dis Control & Prevent, NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH USA. [Hitchcock, Edward M.; Nakata, Akinori] Ctr Dis Control & Prevent, NIOSH, Div Appl Res & Technol, Cincinnati, OH USA. [Chen, Guang X.; Lincoln, Jennifer E.] Ctr Dis Control & Prevent, NIOSH, Div Safety Res, Morgantown, WV USA. RP Birdsey, J (reprint author), NIOSH, 4676 Columbia Pkwy,MS-R17, Cincinnati, OH 45226 USA. EM JBirdsey@cdc.gov FU National Institute for Occupational Safety and Health; Federal Motor Carrier Safety Administration, Department of Transportation; Federal Motor Carrier Safety Administration; NIOSH FX This work was funded by the National Institute for Occupational Safety and Health with partial support from the Federal Motor Carrier Safety Administration, Department of Transportation. This project was partially funded by the Federal Motor Carrier Safety Administration, and the balance of the funding came from NIOSH. NR 57 TC 9 Z9 9 U1 2 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1076-2752 EI 1536-5948 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD FEB PY 2015 VL 57 IS 2 BP 210 EP 216 DI 10.1097/JOM.0000000000000338 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CB2VO UT WOS:000349486700018 PM 25654523 ER PT J AU Chandler, JC Sutherland, MD Harton, MR Molins, CR Anderson, RV Heaslip, DG Bosio, CM Belisle, JT AF Chandler, Jeffrey C. Sutherland, Marjorie D. Harton, Marisa R. Molins, Claudia R. Anderson, Rebecca V. Heaslip, Darragh G. Bosio, Catharine M. Belisle, John T. TI Francisella tularensis LVS Surface and Membrane Proteins as Targets of Effective Post-Exposure Immunization for Tularemia SO JOURNAL OF PROTEOME RESEARCH LA English DT Article DE Francisella tularensis; surface proteome; membrane proteome; adaptive immunity; antibodies ID CULTURE FILTRATE PROTEINS; LIVE VACCINE STRAIN; VIRULENT TYPE-A; PROTEOMIC ANALYSIS; ANTIBODY-RESPONSE; IMMUNOREACTIVE ANTIGENS; RESPIRATORY CHALLENGE; STATISTICAL-MODEL; MASS-SPECTROMETRY; ENRICHED FRACTION AB Francisella tularensis causes disease (tularemia) in a large number of mammals, including man. We previously demonstrated enhanced efficacy of conventional antibiotic therapy for tularemia by postexposure passive transfer of immune sera developed against a F. tularensis LVS membrane protein fraction (MPF). However, the protein composition of this immunogenic fraction was not defined. Proteomic approaches were applied to define the protein composition and identify the immunogens of MPF. MPF consisted of at least 299 proteins and 2-D Western blot analyses using sera from MPF-immunized and F. tularensis LVS-vaccinated mice coupled to liquid chromatography-tandem mass spectrometry identified 24 immunoreactive protein spots containing 45 proteins. A reverse vaccinology approach that applied labeling of F. tularensis LVS surface proteins and bioinformatics was used to reduce the complexity of potential target immunogens. Bioinformatics analyses of the immunoreactive proteins reduced the number of immunogen targets to 32. Direct surface labeling of F. tularensis LVS resulted in the identification of 31 surface proteins. However, only 13 of these were reactive with MPF and/or F. tularensis LVS immune sera. Collectively, this use of orthogonal proteomic approaches reduced the complexity of potential immunogens in MPF by 96% and allowed for prioritization of target immunogens for antibody-based immunotherapies against tularemia. C1 [Chandler, Jeffrey C.; Sutherland, Marjorie D.; Harton, Marisa R.; Heaslip, Darragh G.; Belisle, John T.] Colorado State Univ, Dept Microbiol Immunol & Pathol, Rocky Mt Reg Ctr Excellence Biodef & Emerging Inf, Ft Collins, CO 80523 USA. [Molins, Claudia R.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. [Anderson, Rebecca V.; Bosio, Catharine M.] NIAID, Rocky Mt Lab, NIH, Hamilton, MT 59840 USA. RP Belisle, JT (reprint author), Colorado State Univ, Dept Microbiol Immunol & Pathol, Rocky Mt Reg Ctr Excellence Biodef & Emerging Inf, Campus Delivery 0922, Ft Collins, CO 80523 USA. EM John.Belisle@colostate.edu RI Bosio, Catharine/D-7456-2015; Belisle, John/B-8944-2017 OI Belisle, John/0000-0002-2539-2798 FU National Institutes of Health, National Institute of Allergy and Infectious Diseases [U54 AI-065357] FX This research was supported by National Institutes of Health, National Institute of Allergy and Infectious Diseases grant: U54 AI-065357. NR 52 TC 1 Z9 1 U1 0 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1535-3893 EI 1535-3907 J9 J PROTEOME RES JI J. Proteome Res. PD FEB PY 2015 VL 14 IS 2 BP 664 EP 675 DI 10.1021/pr500628k PG 12 WC Biochemical Research Methods SC Biochemistry & Molecular Biology GA CA9WV UT WOS:000349276400008 PM 25494920 ER PT J AU Blackwell, DL AF Blackwell, Debra L. TI Modeling Receipt of Influenza A(H1N1)pdm09 Vaccinations Among US Children During the 2009-2010 Flu Season Findings From the 2010 National Health Interview Survey SO MEDICAL CARE LA English DT Article DE pH1N1 vaccination; children; United States; family structure; seasonal flu vaccination ID UNITED-STATES; FAMILY-STRUCTURE; COVERAGE; SURVEILLANCE; BENEFITS; HEALTH; VIRUS AB Objective: Using 32 weeks of data from the 2010 National Health Interview Survey, factors associated with receipt of influenza A(H1N1)pdm09 vaccinations among US children during October 2009 through February 2010 are examined. Methods: Logistic models estimated receipt of first dose by January 1, 2010 for all children aged 4.5 months through 17 years and receipt of second dose by February 1, 2010 for children aged 6 months through 9 years who received a first dose, using demographic characteristics and measures of family structure, parental education, family income, access to health care, and chronic condition status. All analyses were weighted to yield nationally representative results for the US child population. Results: Receipt of a seasonal influenza vaccination in the 12 months before October 2009 as well as race/ethnicity, family structure, and various measures representing family socioeconomic status were statistically significant correlates of receipt of the first pH1N1 dose, whereas children's asthma and chronic condition status were not. Conclusions: In the event of future pandemics, public health officials may utilize these findings to target particular segments of the US child population that may have been underserved during the 2009 influenza pandemic. C1 Ctr Dis Control & Prevent CDC, Natl Ctr Hlth Stat, Hyattsville, MD 20781 USA. RP Blackwell, DL (reprint author), Ctr Dis Control & Prevent CDC, Natl Ctr Hlth Stat, 3311 Toledo Rd,Room 2326, Hyattsville, MD 20781 USA. EM dblackwell@cdc.gov FU Intramural CDC HHS [CC999999] NR 38 TC 0 Z9 0 U1 2 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0025-7079 EI 1537-1948 J9 MED CARE JI Med. Care PD FEB PY 2015 VL 53 IS 2 BP 191 EP 198 PG 8 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA CB6ZG UT WOS:000349775000014 PM 25517073 ER PT J AU Phelan, EA Debnam, KJ Anderson, LA Owens, SB AF Phelan, Elizabeth A. Debnam, Katrina J. Anderson, Lynda A. Owens, Steven B. TI A Systematic Review of Intervention Studies to Prevent Hospitalizations of Community-dwelling Older Adults With Dementia SO MEDICAL CARE LA English DT Review DE older adults; hospitalizations; systematic review; intervention studies; patient care management; case management; dementia; Alzheimer disease ID RANDOMIZED CONTROLLED-TRIAL; MANAGED CARE DEMONSTRATION; OCCUPATIONAL-THERAPY; ALZHEIMERS-DISEASE; HEALTH-SERVICES; OUTCOMES; GIVERS; COSTS AB Objectives: To conduct a systematic literature review to determine if there were any intervention strategies that had any measurable effect on acute-care hospitalizations among community-dwelling adults with dementia. Design: Studies were identified by a professional research librarian and content experts. Setting: Community dwelling. Participants: Participants were diagnosed with dementia, severity ranging from mild to severe, and were recruited from health care and community agencies. Measurements: A study met the inclusion criteria if it: (a) was published in English; (b) included a control or comparison group; (c) published outcome data from the intervention under study; (d) reported hospitalization as one of the outcomes; (e) included community-dwelling older adults; and (f) enrolled participants with dementia. Ten studies met all inclusion criteria. Results: Of the 10 studies included, most assessed health services use (ie, hospitalizations) as a secondary outcome. Participants were recruited from a range of health care and community agencies, and most were diagnosed with dementia with severity ratings ranging from mild to severe. Most intervention strategies consisted of face-to-face assessments of the persons living with dementia, their caregivers, and the development and implementation of a care plan. A significant reduction in hospital admissions was not found in any of the included studies, although 1 study did observe a reduction in hospital days. Conclusions: The majority of studies included hospitalizations as a secondary outcome. Only 1 intervention was found to have an effect on hospitalizations. Future work would benefit from strategies specifically designed to reduce and prevent acute hospitalizations in persons with dementia. C1 [Phelan, Elizabeth A.] Univ Washington, Sch Med, Dept Med, Div Gerontol & Geriatr Med, Seattle, WA 98104 USA. [Phelan, Elizabeth A.] Univ Washington, Sch Publ Hlth, Dept Hlth Serv, Seattle, WA 98104 USA. [Debnam, Katrina J.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD USA. [Anderson, Lynda A.] Ctr Dis Control & Prevent, Hlth Aging Program, Div Populat Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Owens, Steven B.] Directors Hlth Promot & Educ, Washington, DC USA. RP Phelan, EA (reprint author), Univ Washington, Sch Med, Dept Med, Div Gerontol & Geriatr Med, 325 9th Ave,POB 359755, Seattle, WA 98104 USA. EM phelane@u.washington.edu FU Centers for Disease Control and Prevention [DP2846-05] FX This review and journal article was supported by the Cooperative Agreement Number, DP2846-05, funded by the Centers for Disease Control and Prevention. The findings and conclusions in this article are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 33 TC 4 Z9 4 U1 10 U2 16 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0025-7079 EI 1537-1948 J9 MED CARE JI Med. Care PD FEB PY 2015 VL 53 IS 2 BP 207 EP 213 PG 7 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA CB6ZG UT WOS:000349775000016 PM 25588136 ER PT J AU Johansson, MA AF Johansson, Michael A. TI Chikungunya on the move SO TRENDS IN PARASITOLOGY LA English DT Editorial Material ID VIRUS-INFECTION; REUNION-ISLAND; EPIDEMIC; SEROPREVALENCE; OUTBREAK; AMERICA AB In December 2013, chikungunya virus (CHIKV) transmission was reported for the first time in the Americas. Since then it has spread quickly, with more than 1 million suspected and confirmed cases being reported in one year, where previously there were only sporadic travel-related cases. Transmission patterns suggest that the epidemic in the southern hemisphere is only beginning and that chikungunya will not go away anytime soon. C1 Ctr Dis Control & Prevent, San Juan, PR USA. RP Johansson, MA (reprint author), Ctr Dis Control & Prevent, San Juan, PR USA. EM mjohansson@cdc.gov FU Intramural CDC HHS [CC999999] NR 15 TC 27 Z9 27 U1 0 U2 13 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1471-4922 EI 1471-5007 J9 TRENDS PARASITOL JI Trends Parasitol. PD FEB PY 2015 VL 31 IS 2 BP 43 EP 45 DI 10.1016/j.pt.2014.12.008 PG 3 WC Parasitology SC Parasitology GA CB6GH UT WOS:000349725000004 PM 25649340 ER PT J AU Dahlgren, FS Haberling, DL McQuiston, JH AF Dahlgren, F. Scott Haberling, Dana L. McQuiston, Jennifer H. TI Q Fever Is Underestimated in the United States: A Comparison of Fatal Q Fever Cases from Two National Reporting Systems SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article AB Two national surveillance systems capturing reports of fatal Q fever were compared with obtained estimates of Q fever underreporting in the United States using capture recapture methods. During 2000-2011, a total of 33 unique fatal Q fever cases were reported through case report forms submitted to the Centers for Disease Control and Prevention and through U.S. death certificate data. A single case matched between both data sets, yielding an estimated 129 fatal cases (95% confidence interval [CI] = 62-1,250) during 2000-2011. Fatal cases of Q fever were underreported through case report forms by an estimated factor of 14 and through death certificates by an estimated factor of 5.2. C1 [Dahlgren, F. Scott] Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Atlanta, GA 30333 USA. Ctr Dis Control & Prevent, Prion & Publ Hlth Off, Atlanta, GA 30333 USA. RP Dahlgren, FS (reprint author), Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, 1600 Clifton Rd NE,MS A-30, Atlanta, GA 30333 USA. EM iot0@cdc.gov NR 11 TC 4 Z9 4 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 2015 VL 92 IS 2 BP 244 EP 246 DI 10.4269/ajtmh.14-0502 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA CA6ZC UT WOS:000349065400013 PM 25404074 ER PT J AU Rajasingham, R Rhein, J Klammer, K Musubire, A Nabeta, H Akampurira, A Mossel, EC Williams, DA Boxrud, DJ Crabtree, MB Miller, BR Rolfes, MA Tengsupakul, S Andama, AO Meya, DB Boulware, DR AF Rajasingham, Radha Rhein, Joshua Klammer, Kate Musubire, Abdu Nabeta, Henry Akampurira, Andrew Mossel, Eric C. Williams, Darlisha A. Boxrud, Dave J. Crabtree, Mary B. Miller, Barry R. Rolfes, Melissa A. Tengsupakul, Supatida Andama, Alfred O. Meya, David B. Boulware, David R. TI Epidemiology of Meningitis in an HIV-Infected Ugandan Cohort SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID XPERT MTB/RIF ASSAY; TUBERCULOUS MENINGITIS; EXTRAPULMONARY TUBERCULOSIS; CRYPTOCOCCAL MENINGITIS; ANTIRETROVIRAL THERAPY; BACTERIAL-MENINGITIS; CEREBROSPINAL-FLUID; GENEXPERT MTB/RIF; MALAWIAN ADULTS; RAPID DIAGNOSIS AB There is limited understanding of the epidemiology of meningitis among human immunodeficiency virus (HIV)-infected populations in sub-Saharan Africa. We conducted a prospective cohort study of HIV-infected adults with suspected meningitis in Uganda, to comprehensively evaluate the etiologies of meningitis. Intensive cerebrospiral fluid (CSF) testing was performed to evaluate for bacterial, viral, fungal, and mycobacterial etiologies, including neurosyphilis,16s ribosomal DNA (rDNA) polymerase chain reaction (PCR) for bacteria, Plex-ID broad viral assay, quantitative-PCR for HSV-1/2, cytomegalovirus (CMV), Epstein-Barr virus (EBV), and Toxoplasma gondii; reverse transcription-PCR (RT-PCR) for Enteroviruses and arboviruses, and Xpert MTB/RIF assay. Cryptococcal meningitis accounted for 60% (188 of 314) of all causes of meningitis. Of 117 samples sent for viral PCR, 36% were EBV positive. Among cryptococcal antigen negative patients, the yield of Xpert MTB/RIF assay was 22% (8 of 36). After exclusion of cryptococcosis and bacterial meningitis, 61% (43 of 71) with an abnormal CSF profile had no definitive diagnosis. Exploration of new TB diagnostics and diagnostic algorithms for evaluation of meningitis in resource-limited settings remains needed, and implementation of cryptococcal diagnostics is critical. C1 Univ Minnesota, Minneapolis, MN USA. Makerere Univ, Infect Dis Inst, Kampala, Uganda. Minnesota Dept Hlth, St Paul, MN USA. Ctr Dis Control & Prevent, Ft Collins, CO USA. Makerere Univ, Coll Hlth Sci, Dept Med, Kampala, Uganda. RP Rajasingham, R (reprint author), 420 Delaware St,MMC250, Minneapolis, MN 55455 USA. EM Radha.Rajasingham@gmail.com OI Boulware, David/0000-0002-4715-0060 FU National Institutes of Health and Fogarty International Center [R21NS065713, K23AI073192, U01AI089244, T32AI055433, R25TW009345, T32HD068229]; CDC; Defense Threat Reduction Agency FX Research support for aspects of this project was received from the National Institutes of Health and Fogarty International Center (R21NS065713, K23AI073192, U01AI089244, T32AI055433, R25TW009345, T32HD068229). Partially funded by an Interagency Agreement between CDC and the Defense Threat Reduction Agency. NR 40 TC 8 Z9 8 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 2015 VL 92 IS 2 BP 274 EP 279 DI 10.4269/ajtmh.14-0452 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA CA6ZC UT WOS:000349065400019 PM 25385864 ER PT J AU Garcia, MN Aguilar, D Gorchakov, R Rossmann, SN Montgomery, SP Rivera, H Woc-Colburn, L Hotez, PJ Murray, KO AF Garcia, Melissa N. Aguilar, David Gorchakov, Rodion Rossmann, Susan N. Montgomery, Susan P. Rivera, Hilda Woc-Colburn, Laila Hotez, Peter J. Murray, Kristy O. TI Case Report: Evidence of Autochthonous Chagas Disease in Southeastern Texas SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID TRYPANOSOMA-CRUZI INFECTION; STATES BLOOD-DONORS; UNITED-STATES; TRANSMISSION; RISK AB Autochthonous transmission of Trypanosoma cruzi in the United States is rarely reported. Here, we describe five newly identified patients with autochthonously acquired infections from a small pilot study of positive blood donors in southeast Texas. Case-patients 1-4 were possibly infected near their residences, which were all in the same region 100 miles west of Houston. Case-patient 5 was a young male with considerable exposure from routine outdoor and camping activities associated with a youth civic organization. Only one of the five autochthonous case-patients received anti-parasitic treatment. Our findings suggest an unrecognized risk of human vector-borne transmission in southeast Texas. Education of physicians and public health officials is crucial for identifying the true disease burden and source of infection in Texas. C1 [Garcia, Melissa N.] Baylor Coll Med, Natl Sch Trop Med, Sect Trop Med, Houston, TX 77008 USA. [Aguilar, David] Baylor Coll Med, Dept Med, Cardiol Sect, Houston, TX 77008 USA. [Rossmann, Susan N.] Gulf Coast Reg Blood Ctr, Houston, TX USA. US Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA USA. Baylor Coll Med, Natl Sch Trop Med, Infect Dis Sect, Houston, TX 77008 USA. RP Garcia, MN (reprint author), Baylor Coll Med, Natl Sch Trop Med, Sect Trop Med, 1102 Bates Ave, Houston, TX 77008 USA. EM mnolan@bcm.edu; daguilar@bcm.edu; rodion@bcm.edu; srossmann@giveblood.org; zqu6@cdc.gov; igi2@cdc.gov; lailawoc@gmail.com; hotez@bcm.edu; kmurray@bcm.edu OI Hotez, Peter/0000-0001-8770-1042 FU Baylor College of Medicine's Cardiovascular Research Institute FX This study was generously funded by an intramural pilot grant from Baylor College of Medicine's Cardiovascular Research Institute. NR 22 TC 19 Z9 20 U1 1 U2 11 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 2015 VL 92 IS 2 BP 325 EP 330 DI 10.4269/ajtmh.14-0238 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA CA6ZC UT WOS:000349065400026 PM 25371187 ER PT J AU O'Keefe, KA Eberhard, ML Shafir, SC Wilkins, P Ash, LR Sorvillo, FJ AF O'Keefe, Kaitlin A. Eberhard, Mark L. Shafir, Shira C. Wilkins, Patricia Ash, Lawrence R. Sorvillo, Frank J. TI Cysticercosis-Related Hospitalizations in the United States, 1998-2011 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID LOS-ANGELES-COUNTY; SOLIUM CYSTICERCOSIS; NEUROCYSTICERCOSIS; INFECTIONS; CALIFORNIA; HOUSTON; TEXAS; DEATHS; BURDEN; OREGON AB Cysticercosis has become increasingly recognized as an important infection in the United States in recent decades. Despite its potential impact, there is a lack of comprehensive information on the nationwide burden of disease. To better define the burden of cysticercosis in the United States, we analyzed in-patient records using the Nationwide Inpatient Sample for 1998-2011 to estimate cysticercosis-related hospitalizations and patient/institutional characteristics. There were an estimated 33,060 (95% confidence interval [95% CI] = 29,610.5-36,510.3) cysticercosis-related hospitalizations nationwide, representing a hospitalization rate of 8.03 per million population. The highest proportion of cases were male (54.8%), Hispanic (62.0%), aged 18-44 (58.8%), and occurred in the West (45.1%). An estimated 459 deaths occurred, representing an in-hospital case-fatality rate of 1.4%. These findings indicate the burden of cysticercosis-related hospitalizations in the United States is considerable and may be greater than currently appreciated. Cysticercosis should be a nationally reportable disease. C1 [O'Keefe, Kaitlin A.] Calif State Univ Northridge, Dept Hlth Sci, Northridge, CA 91330 USA. [Shafir, Shira C.; Ash, Lawrence R.; Sorvillo, Frank J.] Univ Calif Los Angeles, Dept Epidemiol, Fielding Sch Publ Hlth, Los Angeles, CA USA. [Eberhard, Mark L.; Wilkins, Patricia] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA USA. RP O'Keefe, KA (reprint author), Calif State Univ Northridge, Dept Hlth Sci, 18111 Nordhoff St, Northridge, CA 91330 USA. EM kaitlin.okeefe@csun.edu; mle1@cdc.gov; sshafir@ucla.edu; pma1@cdc.gov; larryash@ucla.edu; fsorvill@ucla.edu NR 33 TC 1 Z9 1 U1 0 U2 8 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 2015 VL 92 IS 2 BP 354 EP 359 DI 10.4269/ajtmh.14-0506 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA CA6ZC UT WOS:000349065400031 PM 25385857 ER PT J AU Gerbi, GB Williams, R Bakamutumaho, B Liu, S Downing, R Drobeniuc, J Kamili, S Xu, FJ Holmberg, SD Teshale, EH AF Gerbi, Gemechu B. Williams, Roxanne Bakamutumaho, Barnabas Liu, Stephen Downing, Robert Drobeniuc, Jan Kamili, Saleem Xu, Fujie Holmberg, Scott D. Teshale, Eyasu H. TI Hepatitis E as a Cause of Acute Jaundice Syndrome in Northern Uganda, 2010-2012 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ACUTE VIRAL-HEPATITIS; E VIRUS; LARGE OUTBREAK; GLOBAL BURDEN AB Hepatitis E virus (HEY) is a common cause of acute viral hepatitis in developing countries; however, its contribution to acute jaundice syndrome is not well-described. A large outbreak of hepatitis E occurred in northern Uganda from 2007 to 2009. In response to this outbreak, acute jaundice syndrome surveillance was established in 10 district healthcare facilities to determine the proportion of cases attributable to hepatitis E. Of 347 acute jaundice syndrome cases reported, the majority (42%) had hepatitis E followed by hepatitis B (14%), malaria (10%), hepatitis C (5%), and other/unknown (29%). Of hepatitis E cases, 72% occurred in Kaboong district, and 68% of these cases occurred between May and August of 2011. Residence in Kaabong district was independently associated with hepatitis E (adjusted odds ratio = 13; 95% confidence interval = 7-24). The findings from this surveillance show that an outbreak and sporadic transmission of hepatitis E occur in northern Uganda. C1 Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Bakamutumaho, Barnabas] WHO, Influenza Collaborating Ctr, Uganda Virus Res Inst, Ctr Dis Control & Prevent,Influenza Surveillance, Entebbe, Uganda. [Downing, Robert] Ctr Dis Control & Prevent Uganda, Kampala, Uganda. RP Gerbi, GB (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,Mailstop G-37, Atlanta, GA 30333 USA. EM ggerbi@msm.edu; rewilli8@yahoo.com; bbarnabas2001@yahoo.com; ice5@cdc.gov; rqd6@ug.cdc.gov; jqd6@cdc.gov; sek6@cdc.gov; fax1@cdc.gov; sdh1@cdc.gov; eht4@cdc.gov NR 15 TC 4 Z9 5 U1 1 U2 7 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 2015 VL 92 IS 2 BP 411 EP 414 DI 10.4269/ajtmh.14-0196 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA CA6ZC UT WOS:000349065400039 PM 25448237 ER PT J AU Savage, HM Ledermann, JP Yug, L Burkhalter, KL Marfel, M Hancock, WT AF Savage, Harry M. Ledermann, Jeremy P. Yug, Laurence Burkhalter, Kristen L. Marfel, Maria Hancock, W. Thane TI Incrimination of Aedes (Stegomyia) hensilli Farner as an Epidemic Vector of Chikungunya Virus on Yap Island, Federated States of Micronesia, 2013 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID INDIAN-OCEAN OUTBREAK; ALBOPICTUS MOSQUITOS; TRANSMISSION; INFECTION; AEGYPTI; ALPHAVIRUSES; EVOLUTION; REGION AB Two species of Aedes (Stegomyia) were collected in response to the first chikungunya virus (CHIKV) outbreak on Yap Island: the native species Ae. hensilli Farner and the introduced species Ae. aegypti (L.). Fourteen CHIKV-positive mosquito pools were detected. Six pools were composed of female Ae. hensilli, six pools were composed of female Ae. aegypti, one pool was composed of male Ae. hensilli, and one pool contained female specimens identified as Ae. (Stg.) spp. Infection rates were not significantly different between female Ae. hensilli and Ae. aegypti. The occurrence of human cases in all areas of Yap Island and the greater number of sites that yielded virus from Ae. hensilli combined with the ubiquitous distribution of this species incriminate Ae. hensilli as the most important vector of CHIKV during the outbreak. Phylogenic analysis shows that virus strains on Yap are members of the Asia lineage and closely related to strains currently circulating in the Caribbean. C1 [Savage, Harry M.; Ledermann, Jeremy P.; Burkhalter, Kristen L.] Ctr Dis Control & Prevent, Ft Collins, CO 80521 USA. [Yug, Laurence; Marfel, Maria; Hancock, W. Thane] Yap Hosp, Yap, Micronesia. [Yug, Laurence; Marfel, Maria; Hancock, W. Thane] Yap State Dept Hlth, Yap, Micronesia. RP Savage, HM (reprint author), Ctr Dis Control & Prevent, 3156 Rampart Rd, Ft Collins, CO 80521 USA. EM HMS1@cdc.gov; bpj7@cdc.gov; lyug@fsmhealth.fm; ktb3@cdc.gov; MMarfel@fsmhealth.fm; thane@fsmhealth.fm FU Global Disease Detection Operations Center Outbreak Response Contingency Fund; Global Disease Detection Operations Center; Centers for Disease Control and Prevention FX Travel and associated shipping costs in support of this project were provided by the Global Disease Detection Operations Center Outbreak Response Contingency Fund, Global Disease Detection Operations Center, Centers for Disease Control and Prevention. NR 36 TC 6 Z9 6 U1 1 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 2015 VL 92 IS 2 BP 429 EP 436 DI 10.4269/ajtmh.14-0374 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA CA6ZC UT WOS:000349065400042 PM 25404070 ER PT J AU Holtz, TH Pattanasin, S Chonwattana, W Tongtoyai, J Chaikummao, S Varangrat, A Mock, PA AF Holtz, Timothy H. Pattanasin, Sarika Chonwattana, Wannee Tongtoyai, Jaray Chaikummao, Supaporn Varangrat, Anchalee Mock, Philip A. TI Longitudinal Analysis of Key HIV-Risk Behavior Patterns and Predictors in Men Who Have Sex with Men, Bangkok, Thailand SO ARCHIVES OF SEXUAL BEHAVIOR LA English DT Article DE MSM; HIV; Risk behaviors; Cohort analysis; Thailand ID SILDENAFIL VIAGRA USE; METHAMPHETAMINE USE; BISEXUAL MEN; YOUNG MEN; SAN-FRANCISCO; UNITED-STATES; INFECTION; GAY; PREVENTION; COUNTRIES AB The HIV incidence among Thai men who have sex with men (MSM) enrolled in the Bangkok MSM Cohort Study (BMCS) has remained high since its inception in 2006. The purpose of this BMCS analysis was to determine: (1) changes in three HIV-risk behaviors (unprotected anal intercourse (UAI), recreational drug use, and multiple sexual partners i.e., more than four male/transgender partner) over time; and (2) factors associated with each one separately. Thai MSM aged 18 years or older and living in Bangkok were eligible to participate in the BMCS. At each follow-up visit, participants were asked to report their sexual and drug behaviors in the previous 4 months. We conducted a longitudinal analysis using generalized estimating equations logistic regression that included 1,569 MSM who were enrolled from 2006 to 2010 and contributed at least one follow-up visit. For each four-month visit increase, we found a 2, 1, and 1 % decrease in odds for reported UAI, recreational drug use, and multiple sexual partners, respectively. We found significant predictors associated with three HIV-risk behaviors such as binge drinking, participation in group sex, and use of erectile dysfunction drugs. The statistically significant decrease in odds of HIV-risk behaviors among the participants is encouraging; however, continued vigilance is required to address the factors associated with HIV-risk behaviors through currently available interventions reaching MSM. C1 [Holtz, Timothy H.; Pattanasin, Sarika; Chonwattana, Wannee; Tongtoyai, Jaray; Chaikummao, Supaporn; Varangrat, Anchalee; Mock, Philip A.] US Ctr Dis Control & Prevent Collaborat, HIV STD Res Program, Thailand Minist Publ Hlth, Nonthaburi 11000, Thailand. [Holtz, Timothy H.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. RP Holtz, TH (reprint author), US Ctr Dis Control & Prevent Collaborat, HIV STD Res Program, Thailand Minist Publ Hlth, POB 139, Nonthaburi 11000, Thailand. EM tkh3@cdc.gov NR 39 TC 4 Z9 4 U1 0 U2 4 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0004-0002 EI 1573-2800 J9 ARCH SEX BEHAV JI Arch. Sex. Behav. PD FEB PY 2015 VL 44 IS 2 BP 341 EP 348 DI 10.1007/s10508-014-0427-7 PG 8 WC Psychology, Clinical; Social Sciences, Interdisciplinary SC Psychology; Social Sciences - Other Topics GA CB3SB UT WOS:000349547500007 PM 25637308 ER PT J AU Beggs, PJ Katelaris, CH Medek, D Johnston, FH Burton, PK Campbell, B Jaggard, AK Vicendese, D Bowman, DMJS Godwin, I Huete, AR Erbas, B Green, BJ Newnham, RM Newbigin, E Haberle, SG Davies, JM AF Beggs, Paul J. Katelaris, Constance H. Medek, Danielle Johnston, Fay H. Burton, Pamela K. Campbell, Bradley Jaggard, Alison K. Vicendese, Don Bowman, David M. J. S. Godwin, Ian Huete, Alfredo R. Erbas, Bircan Green, Brett J. Newnham, Rewi M. Newbigin, Ed Haberle, Simon G. Davies, Janet M. TI Differences in grass pollen allergen exposure across Australia SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH LA English DT Article DE pollen; allergen; season; allergic rhinitis; allergic asthma ID AIRBORNE POLLEN; UNITED-KINGDOM; CLIMATE-CHANGE; HAY-FEVER; ASTHMA; SEASON; AEROALLERGENS; PREVALENCE; MELBOURNE; EPIDEMICS AB Objective: Allergic rhinitis and allergic asthma are important chronic diseases posing serious public health issues in Australia with associated medical, economic, and societal burdens. Pollen are significant sources of clinically relevant outdoor aeroallergens, recognised as both a major trigger for, and cause of, allergic respiratory diseases. This study aimed to provide a national, and indeed international, perspective on the state of Australian pollen data using a large representative sample. Methods: Atmospheric grass pollen concentration is examined over a number of years within the period 1995 to 2013 for Brisbane, Canberra, Darwin, Hobart, Melbourne, and Sydney, including determination of the clinical' grass pollen season and grass pollen peak. Results: The results of this study describe, for the first time, a striking spatial and temporal variability in grass pollen seasons in Australia, with important implications for clinicians and public health professionals, and the Australian grass pollen-allergic community. Conclusions: These results demonstrate that static pollen calendars are of limited utility and in some cases misleading. This study also highlights significant deficiencies and limitations in the existing Australian pollen monitoring and data. Implications: Establishment of an Australian national pollen monitoring network would help facilitate advances in the clinical and public health management of the millions of Australians with asthma and allergic rhinitis. C1 [Beggs, Paul J.; Jaggard, Alison K.] Macquarie Univ, Dept Geog & Environm, Sydney, NSW 2109, Australia. [Katelaris, Constance H.] Univ Western Sydney, Dept Med, Campbelltown Hosp, Penrith, NSW 1797, Australia. [Katelaris, Constance H.] Univ Western Sydney, Sch Med, Penrith, NSW 1797, Australia. [Medek, Danielle] Harvard Univ, Sch Publ Hlth, Cambridge, MA 02138 USA. [Johnston, Fay H.] Univ Tasmania, Menzies Res Inst Tasmania, Hobart, Tas 7001, Australia. [Burton, Pamela K.] Campbelltown Hosp, Dept Med, Campbelltown, NSW, Australia. [Campbell, Bradley; Godwin, Ian] Univ Queensland, Sch Agr & Food Sci, Brisbane, Qld 4072, Australia. [Vicendese, Don; Erbas, Bircan] La Trobe Univ, Sch Publ Hlth & Human Biosci, Bundoora, Vic 3086, Australia. [Bowman, David M. J. S.] Univ Tasmania, Sch Plant Sci, Hobart, Tas 7001, Australia. [Huete, Alfredo R.] Univ Technol Sydney, Fac Sci, Sydney, NSW 2007, Australia. [Green, Brett J.] Ctr Dis Control & Prevent, Allergy & Clin Immunol Branch, Charleston, WV USA. [Newnham, Rewi M.] Victoria Univ Wellington, Sch Geog Environm & Earth Sci, Wellington, New Zealand. [Newbigin, Ed] Univ Melbourne, Sch Bot, Melbourne, Vic 3010, Australia. [Haberle, Simon G.] Australian Natl Univ, Dept Archaeol & Nat Hist, Canberra, ACT 0200, Australia. [Davies, Janet M.] Univ Queensland, Sch Med, Brisbane, Qld 4072, Australia. RP Beggs, PJ (reprint author), Macquarie Univ, Fac Sci, Dept Geog & Environm, Sydney, NSW 2109, Australia. EM paul.beggs@mq.edu.au RI Davies, Janet/C-7989-2009; Huete, Alfredo/C-1294-2008; Bowman, David/A-2930-2011; OI Huete, Alfredo/0000-0003-2809-2376; Bowman, David/0000-0001-8075-124X; Haberle, Simon/0000-0001-5802-6535; Newbigin, Ed/0000-0002-9644-302X FU Australian Centre for Ecological Analysis and Synthesis (ACEAS); Terrestrial Ecosystem Research Network (TERN) by Australian Government through the National Collaborative Research Infrastructure Strategy; Super Science Initiative; MSD; New South Wales Government through Environmental Trust [2011/RD/0049] FX Funding support for the Working Group came from the Australian Centre for Ecological Analysis and Synthesis (ACEAS), Terrestrial Ecosystem Research Network (TERN), which is supported by the Australian Government through the National Collaborative Research Infrastructure Strategy and the Super Science Initiative. MSD provided additional independent untied co-sponsorship for the Working Group. The authors wish to thank the staff of ACEAS, TERN for assistance in organising Workshops 1 and 2 of the Working Group "Understanding Australian aerobiology to monitor environmental change and human allergenic exposure", North Stradbroke Island, Australia (11-15 March and 4-8 November 2013 respectively). Alison Jaggard has been assisted by the New South Wales Government through its Environmental Trust (project reference number 2011/RD/0049). The findings and the conclusions in this report are those of the authors and do not necessarily represent the views of the US National Institute for Occupational Safety and Health. The authors wish to thank Associate Professor Jeroen Buters (Germany), Associate Professor Frank Murray (Australia), and Dr Michel Thibaudon (France) for their contributions to this research. Finally, we also thank two anonymous reviewers of the submitted manuscript who provided positive, thoughtful, and constructive comments on it. NR 44 TC 5 Z9 6 U1 0 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1326-0200 EI 1753-6405 J9 AUST NZ J PUBL HEAL JI Aust. N. Z. Publ. Health PD FEB PY 2015 VL 39 IS 1 BP 51 EP 55 DI 10.1111/1753-6405.12325 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CB0HT UT WOS:000349307300011 PM 25648730 ER PT J AU Waghmare, A Kuypers, JM Xie, H Leisenring, W Campbell, AP Jerome, KR Englund, JA Boeckh, MJ AF Waghmare, Alpana Kuypers, Jane M. Xie, Hu Leisenring, Wendy Campbell, Angela P. Jerome, Keith R. Englund, Janet A. Boeckh, Michael J. TI Viral Load in Hematopoietic Cell Transplant Recipients Infected with Human Rhinovirus Correlates with Burden of Symptoms SO BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION LA English DT Meeting Abstract CT BMT Tandem Meetings CY FEB 11-15, 2015 CL San Diego, CA C1 [Waghmare, Alpana; Englund, Janet A.] Seattle Childrens Hosp, Seattle, WA USA. [Waghmare, Alpana; Kuypers, Jane M.; Jerome, Keith R.; Englund, Janet A.; Boeckh, Michael J.] Univ Washington, Seattle, WA 98195 USA. [Waghmare, Alpana; Xie, Hu; Leisenring, Wendy; Jerome, Keith R.; Boeckh, Michael J.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Campbell, Angela P.] CDC, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1083-8791 EI 1523-6536 J9 BIOL BLOOD MARROW TR JI Biol. Blood Marrow Transplant. PD FEB PY 2015 VL 21 IS 2 SU 1 MA 459 BP S317 EP S318 PG 2 WC Hematology; Immunology; Transplantation SC Hematology; Immunology; Transplantation GA CA0UZ UT WOS:000348633000461 ER PT J AU Hariri, S Unger, ER Schafer, S Niccolai, LM Park, IU Bloch, KC Bennett, NM Steinau, M Johnson, ML Markowitz, LE AF Hariri, Susan Unger, Elizabeth R. Schafer, Sean Niccolai, Linda M. Park, Ina U. Bloch, Karen C. Bennett, Nancy M. Steinau, Martin Johnson, Michelle L. Markowitz, Lauri E. CA HPV-IMPACT Working Grp TI HPV Type Attribution in High-Grade Cervical Lesions: Assessing the Potential Benefits of Vaccines in a Population-Based Evaluation in the United States SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Article ID PAPILLOMAVIRUS GENOTYPE ATTRIBUTION; VACCINATION COVERAGE; CANCER; WORLDWIDE; NEOPLASIA; INFECTION; PRECANCER; BURDEN; IMPACT; WOMEN AB Background: Two currently available vaccines targeting human papillomavirus (HPV) types 16 and 18 could prevent 70% of cervical cancers and 50% of high-grade cervical lesions. Next-generation vaccines against additional types, such as a candidate 9-valent vaccine against HPV6/11/16/18/31/33/45/52/58, could further reduce HPV-associated disease burden. Methods: HPV was typed in archived tissues from women ages 21 to 39 years residing in five catchment areas in the United States with cervical intraepithelial neoplasia 2/3 and adenocarcinoma in situ (CIN2+) using L1 consensus PCR and type-specific hybridization. Type attribution was estimated using weights to account for lesions with multiple types detected. Results: From 2008 to 2011, 5,498 of 6,306 (87.2%) specimens obtained from 8,469 women with CIN2+ had valid typing results; HPV DNA was detected in 97.3%. Overall, 50.1% of lesions were attributable to HPV16/18, ranging from 50.3% to 52.4% among those ages 21 to 34 years, and significantly declined in 35 to 39 year-olds (43.5%). HPV16/18 attribution was higher in non-Hispanic whites (56.4%) versus racial/ethnic minorities (range, 41.8%-45.9%; P < 0.001). HPV31/33/45/52/58 attribution was 25.0% overall and increased with age (P < 0.001). A higher proportion of CIN2+ was attributable to HPV31/33/45/52/58 in non-Hispanic black (29.9%), Hispanic (29.2%), and Asian (33.1%) women compared with non-Hispanic whites (22.8%; P < 0.001). Conclusions: Overall, 75% of lesions were attributable to 7 oncogenic HPV types: 50% to HPV16/18 and 25% to HPV31/33/45/52/58. HPV16/18 had the largest attributable fraction in CIN2+ across all subpopulations, although to a lesser extent in older women and racial/ethnic minorities. Impact: Vaccines targeting additional oncogenic HPV types could prevent more high-grade cervical lesions, especially among racial/ethnic minorities. (C) 2014 AACR. C1 [Hariri, Susan; Johnson, Michelle L.; Markowitz, Lauri E.] Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA. [Unger, Elizabeth R.; Steinau, Martin] Ctr Dis Control & Prevent, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Schafer, Sean] Oregon Publ Hlth Div, Ctr Publ Hlth Practice, HIV STD TB Program, Portland, OR USA. [Niccolai, Linda M.] Yale Univ, Sch Publ Hlth, Dept Epidemiol Microbial Dis, New Haven, CT USA. [Park, Ina U.] Calif Dept Publ Hlth, STD Control Branch, Richmond, CA USA. [Bloch, Karen C.] Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37212 USA. [Bloch, Karen C.] Vanderbilt Univ, Sch Med, Dept Hlth Policy, Nashville, TN 37212 USA. [Bennett, Nancy M.] Univ Rochester, Sch Med & Dent, Ctr Community Hlth, Rochester, NY USA. [Bennett, Nancy M.] Univ Rochester, Sch Med & Dent, Dept Med, Rochester, NY 14642 USA. RP Hariri, S (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,MS E-02, Atlanta, GA 30333 USA. EM bse4@cdc.gov FU U.S. Centers for Disease Control and Prevention [CIU01000307] FX S. Schafer, L.M. Niccolai, I.U. Park, K.C. Bloch, and N.M. Bennett were supported by the U.S. Centers for Disease Control and Prevention cooperative agreement CIU01000307. NR 31 TC 14 Z9 14 U1 3 U2 8 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1055-9965 EI 1538-7755 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD FEB PY 2015 VL 24 IS 2 BP 393 EP 399 DI 10.1158/1055-9965.EPI-14-0649 PG 7 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA CB1XY UT WOS:000349422500010 PM 25416715 ER PT J AU Klevens, J Barnett, SBL Florence, C Moore, D AF Klevens, Joanne Barnett, Sarah Beth L. Florence, Curtis Moore, DeWayne TI Exploring policies for the reduction of child physical abuse and neglect SO CHILD ABUSE & NEGLECT LA English DT Article DE Child physical abuse; Child neglect; Policy evaluation ID OF-THE-LITERATURE; MALTREATMENT; INCOME; SUBSTANTIATION; NEIGHBORHOODS; DIRECTIONS; COMMUNITY; FAMILIES; VIOLENCE; ECOLOGY AB Policies can be powerful tools for prevention given their potential to affect conditions that can improve population-level health. Given the dearth of empirical research on policies' impacts on child maltreatment, this article (a) identifies 37 state policies that might have impacts on the social determinants of child maltreatment; (b) identifies available data sources documenting the implementation of 31 policies; and (c) utilizes the available data to explore effects of 11 policies (selected because they had little missing data) on child maltreatment rates. These include two policies aimed at reducing poverty, two temporary assistance to needy families policies, two policies aimed at increasing access to child care, three policies aimed at increasing access to high quality pre-K, and three policies aimed at increasing access to health care. Multi-level regression analyses between within-state trends of child maltreatment investigation rates and these 11 policies, controlling for states' childhood poverty, adults without a high school diploma, unemployment, child burden, and race/ethnicity, identified two that were significantly associated with decreased child maltreatment rates: lack of waitlists to access subsidized child care and policies that facilitate continuity of child health care. These findings are correlational and are limited by the quality and availability of the data. Future research might focus on a reduced number of states that have good quality administrative data or population-based survey data on child maltreatment or reasonable proxies for child maltreatment and where data on the actual implementation of specific policies of interest can be documented. Published by Elsevier Ltd. C1 [Klevens, Joanne; Barnett, Sarah Beth L.; Florence, Curtis] Ctr Dis Control & Prevent, Div Violence Prevent, Atlanta, GA 30333 USA. [Moore, DeWayne] Clemson Coll Business & Behav Sci, Sch Psychol, Atlanta, GA USA. RP Klevens, J (reprint author), Ctr Dis Control & Prevent, Div Violence Prevent, Atlanta, GA 30333 USA. OI Klevens, Joanne/0000-0003-4151-8853 FU AHRQ HHS [T32 HS013853]; Intramural CDC HHS [CC999999] NR 94 TC 10 Z9 10 U1 5 U2 23 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0145-2134 EI 1873-7757 J9 CHILD ABUSE NEGLECT JI Child Abuse Negl. PD FEB PY 2015 VL 40 BP 1 EP 11 DI 10.1016/j.chiabu.2014.07.013 PG 11 WC Family Studies; Psychology, Social; Social Work SC Family Studies; Psychology; Social Work GA CB3ES UT WOS:000349511600001 PM 25124051 ER PT J AU Peterman, TA Newman, DR Maddox, L Schmitt, K Shiver, S AF Peterman, Thomas A. Newman, Daniel R. Maddox, Lorene Schmitt, Karla Shiver, Stacy TI Risk for HIV following a diagnosis of syphilis, gonorrhoea or chlamydia: 328,456 women in Florida, 2000-2011 SO INTERNATIONAL JOURNAL OF STD & AIDS LA English DT Article DE HIV; AIDS; sexually transmitted infection; HIV incidence; syphilis; gonorrhoea; chlamydia; women; epidemiology; prevention; North America ID UNITED-STATES; PREVENTION; INFECTION; TRANSMISSION; PROPHYLAXIS; COHORT; AREAS; CITY AB Several effective interventions are available for preventing HIV in women. Targeting interventions requires understanding their risk of acquiring HIV. We used surveillance data to estimate risks of HIV acquisition for 13-59-year-old women following a diagnosis of syphilis, gonorrhoea or chlamydia in Florida during 2000-2009. We excluded women reported with HIV before their STI, and measured HIV reported subsequent to STI (through 2011). Rates were compared to women with no reported STI. A total of 328,456 women had: syphilis (3325), gonorrhoea (67,784) or chlamydia (257,347). During 2,221,944 person-years of follow-up, 2118 of them were diagnosed with HIV. For women with no STI reported, during 64,763,832 person-years, 19,531 were reported with HIV. The crude rate of subsequent HIV diagnosis (per 100,000 person-years) was higher for women diagnosed with syphilis (597.9), gonorrhoea (171.3) or chlamydia (66.3) than women with no STI (30.2). Annual rates of HIV decreased over-all by 61.8% between 2001 and 2011. Women with syphilis or gonorrhoea were at highest risk for HIV and therefore might benefit from intensive counselling. However, they represented only a small fraction of the women who acquired HIV. Most cases of HIV infection among women occurred among the large group of women who were not at highest risk. C1 [Peterman, Thomas A.; Newman, Daniel R.] Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA. [Maddox, Lorene; Schmitt, Karla; Shiver, Stacy] Florida Dept Hlth, Div Dis Control & Hlth Protect, Tallahassee, FL USA. [Schmitt, Karla] Florida State Univ, Coll Nursing, Tallahassee, FL 32306 USA. RP Peterman, TA (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, Mailstop E02,1600 Clifton Rd, Atlanta, GA 30333 USA. EM tap1@cdc.gov NR 29 TC 8 Z9 8 U1 0 U2 2 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0956-4624 EI 1758-1052 J9 INT J STD AIDS JI Int. J. STD AIDS PD FEB PY 2015 VL 26 IS 2 BP 113 EP 119 DI 10.1177/0956462414531243 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CB0LV UT WOS:000349318500007 PM 24713228 ER PT J AU Dean, BB Hart, RLD Buchacz, K Bozzette, SA Wood, K Brooks, JT AF Dean, Bonnie B. Hart, Rachel L. D. Buchacz, Kate Bozzette, Samuel A. Wood, Kathy Brooks, John T. CA Hops Investigators TI HIV Laboratory Monitoring Reliably Identifies Persons Engaged in Care SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV; retention in care; CD4 cell count; plasma HIV RNA viral load ID RETENTION; INFECTION; RECOMMENDATIONS; ASSOCIATION; GUIDELINES; ADHERENCE; SOCIETY; VISITS; PANEL AB Background:Attendance at biannual medical encounters has been proposed as a minimum national standard for adequate engagement in HIV care. Using data from the HIV Outpatient Study, we analyzed how well dates of HIV-related laboratory testing correlated with attendance at biannual medical encounters.Methods:HIV Outpatient Study is an open prospective cohort study of HIV-infected patients receiving outpatient care in the United States. The data set included dates for laboratory measurements and medical encounters. We included patients with at least 1 HIV laboratory test (CD4 cell count or plasma HIV RNA viral load) during 2010-2011. An HIV laboratory test was defined as associated with a medical encounter if it occurred within 3 weeks of the encounter. We assessed the predictive value of HIV laboratory tests as a proxy for adequate engagement in clinical care, defined as having had 2 HIV laboratory tests within 1 year and performed >90 days apart.Results:A total of 10,321 HIV laboratory tests were recorded from 2909 patients. Adequate engagement in clinical care based on medical encounters was 88.2% and 77.3% when based on laboratory tests. Using HIV laboratory tests to assess engagement had a sensitivity of 85.7%, specificity of 86.0%, and positive and negative predictive values of 97.9% and 44.5%, respectively. Of the 22.7% classified as not engaged in care by the proxy measure, over half (55.5%) were actually engaged.Conclusions:Using laboratory monitoring reliably classified persons as engaged in care. Of the 22.7% of patients classified as not engaged in care, most were actually engaged. C1 [Dean, Bonnie B.; Hart, Rachel L. D.; Bozzette, Samuel A.; Wood, Kathy] Cerner Corp, Kansas City, MO USA. [Buchacz, Kate; Brooks, John T.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. [Bozzette, Samuel A.] Univ Calif San Diego, Dept Med, Div Infect Dis, La Jolla, CA 92093 USA. RP Dean, BB (reprint author), 2800 Rockcreek Pkwy, Kansas City, MO 64117 USA. EM bdean@cerner.com FU Centers for Disease Control and Prevention [200-2001-00133, 200-2006-18797, 200-2011-41872] FX Supported by the Centers for Disease Control and Prevention (Contract Nos. 200-2001-00133, 200-2006-18797, and 200-2011-41872). NR 18 TC 3 Z9 3 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD FEB 1 PY 2015 VL 68 IS 2 BP 133 EP 139 DI 10.1097/QAI.0000000000000406 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AZ8IF UT WOS:000348458200008 PM 25383710 ER PT J AU Moreno, M AF Moreno, Megan TI Risks of Hookah Smoking SO JAMA PEDIATRICS LA English DT Editorial Material AB Tobacco use is the leading preventable cause of death and illness worldwide. During the past 45 years, rates of cigarette smoking have decreased in the United States owing to greater understanding of the health risks of smoking, indoor smoking bans, media and advertising restrictions, and increased public awareness. However, the use of alternative forms of tobacco, such as hookah, is rising, threatening these successful efforts. C1 Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. RP Moreno, M (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6203 EI 2168-6211 J9 JAMA PEDIATR JI JAMA Pediatr. PD FEB PY 2015 VL 169 IS 2 BP 196 EP 196 PG 1 WC Pediatrics SC Pediatrics GA CA8DV UT WOS:000349147700024 PM 25642904 ER PT J AU Muehlenbachs, A Bollweg, B Schulz, T Gregory, R Cummings, P Andrew, T Prial, M Prahlow, J Ritter, J Ng, D Sanders, J Forrester, J Zaki, S AF Muehlenbachs, Atis Bollweg, Brigid Schulz, Thadeus Gregory, Ray Cummings, Peter Andrew, Thomas Prial, Margaret Prahlow, Joseph Ritter, Jana Ng, Dianna Sanders, Jeanine Forrester, Joseph Zaki, Sherif TI Lyme Carditis: Autopsy Findings of 5 Patients With Sudden Cardiac Death SO LABORATORY INVESTIGATION LA English DT Meeting Abstract CT 104th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology CY MAR 21-27, 2015 CL Boston, MA SP US & Canadian Acad Pathol C1 Ctr Dis Control & Prevent, Atlanta, GA USA. CryoLife, Kennesaw, GA USA. Off Chief Med Examiner, Boston, MA USA. Off Chief Med Examiner, Concord, NH USA. Off Med Examiner, Orange Cty, NY USA. Med Fdn, South Bend, IN USA. Indiana Univ Sch Med, South Bend, IN USA. Ctr Dis Control & Prevent, Ft Collins, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0023-6837 EI 1530-0307 J9 LAB INVEST JI Lab. Invest. PD FEB PY 2015 VL 95 SU 1 MA 1569 BP 394A EP 394A PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA CA5KT UT WOS:000348948003070 ER PT J AU Ng, D Sanders, J Zaki, S Shieh, WJ AF Ng, Dianna Sanders, Jeanine Zaki, Sherif Shieh, Wun-Ju TI Grocott Methenamine Silver Stain: An Adjunct Diagnostic Tool in the Identification of Bacteria in Tissues SO LABORATORY INVESTIGATION LA English DT Meeting Abstract CT 104th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology CY MAR 21-27, 2015 CL Boston, MA SP US & Canadian Acad Pathol C1 [Ng, Dianna; Sanders, Jeanine; Zaki, Sherif; Shieh, Wun-Ju] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0023-6837 EI 1530-0307 J9 LAB INVEST JI Lab. Invest. PD FEB PY 2015 VL 95 SU 1 MA 1571 BP 394A EP 394A PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA CA5KT UT WOS:000348948003072 ER PT J AU Catalfamo, M Mawle, A Verthelyi, D AF Catalfamo, Marta Mawle, Alison Verthelyi, Daniela TI Immunology careers at the NIH, FDA and CDC: different paths that focus on advancing public health SO NATURE IMMUNOLOGY LA English DT Article C1 [Catalfamo, Marta] NIAID, Immunoregulat Lab, US NIH, Bethesda, MD 20892 USA. [Mawle, Alison] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Verthelyi, Daniela] US FDA, Ctr Drug Evaluat & Res, Off Biotechnol Prod, Div Therapeut Prot, Silver Spring, MD USA. RP Catalfamo, M (reprint author), NIAID, Immunoregulat Lab, US NIH, Bldg 10, Bethesda, MD 20892 USA. EM catalfam@mail.nih.gov NR 9 TC 1 Z9 1 U1 0 U2 3 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1529-2908 EI 1529-2916 J9 NAT IMMUNOL JI Nat. Immunol. PD FEB PY 2015 VL 16 IS 2 BP 129 EP 132 PG 4 WC Immunology SC Immunology GA AZ3QZ UT WOS:000348143100001 PM 25594454 ER PT J AU Eriksson, CO Uyeki, TM Christian, MD King, MA Braner, DAV Kanter, RK Kissoon, N AF Eriksson, Carl O. Uyeki, Timothy M. Christian, Michael D. King, Mary A. Braner, Dana A. V. Kanter, Robert K. Kissoon, Niranjan TI Care of the Child With Ebola Virus Disease SO PEDIATRIC CRITICAL CARE MEDICINE LA English DT Article DE adolescent; child; critical care; Ebola hemorrhagic fever; Ebola virus; Ebola virus disease; infant; sepsis ID HEMORRHAGIC-FEVER; NONHUMAN-PRIMATES; INFECTED PATIENTS; RESPONSES; CONGO; KIKWIT; TRANSMISSION; PROTECTION; OUTBREAK; SURVIVAL AB Objectives: To provide clinicians with practical considerations for care of children with Ebola virus disease in resource-rich settings. Data Sources: Review of the published medical literature, World Health Organization and government documents, and expert opinion. Data Synthesis: There are limited data regarding Ebola virus disease in children; however, reported case-fatality proportions in children are high. Ebola virus may affect immune regulation and endothelial function differently in children than adults. Considerations for care of children with Ebola virus disease are presented. Conclusions: Ebola virus disease is a severe multisystem disease with high mortality in children and adults. Hospitals and clinicians must prepare to provide care for patients with Ebola virus disease before such patients present for care, with particular attention to rigorous infection control to limit secondary cases. Although there is no proven specific treatment for Ebola virus disease, meticulous supportive care offers patients the best chance of survival. C1 [Eriksson, Carl O.; Braner, Dana A. V.] Oregon Hlth & Sci Univ, Dept Pediat, Div Pediat Crit Care, Portland, OR 97201 USA. [Uyeki, Timothy M.] US Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Christian, Michael D.] Mt Sinai Hosp, Dept Crit Care, Toronto, ON M5G 1X5, Canada. [King, Mary A.] Seattle Childrens Hosp, Seattle, WA USA. [King, Mary A.] Univ Washington, Harborview Med Ctr, Seattle, WA 98104 USA. [Kanter, Robert K.] Virginia Tech, Caril Sch Med, Roanoke, VA USA. [Kanter, Robert K.] Columbia Univ, Natl Ctr Disaster Preparedness, New York, NY USA. [Kissoon, Niranjan] British Columbia Childrens Hosp, Dept Pediat, Vancouver, BC, Canada. [Kissoon, Niranjan] British Columbia Childrens Hosp, Dept Emergency Med, Vancouver, BC, Canada. RP Eriksson, CO (reprint author), Oregon Hlth & Sci Univ, Dept Pediat, Div Pediat Crit Care, 3181 Sw Sam Jackson Pk Rd, Portland, OR 97201 USA. EM eriksson@ohsu.edu FU Baton Rouge Area Foundation FX Dr. Uyeki disclosed government work. Dr. Christian received support for article research and disclosed government work. Dr. Kanter disclosed past employment with SUNY Updated Medical University and current employment with the Virginia Tech Carilion School of Medicine. He received support for travel from the National Center for Disaster Preparedness, Columbia University; the American College of Chest Physicians; and the NYS DOH Task Force on Life and the Law. His institution consulted for the National Center for Disaster Preparedness, Columbia University; and received grant support from the Baton Rouge Area Foundation. The remaining authors have disclosed that they do not have any potential conflicts of interest. NR 56 TC 5 Z9 5 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1529-7535 EI 1947-3893 J9 PEDIATR CRIT CARE ME JI Pediatr. Crit. Care Med. PD FEB PY 2015 VL 16 IS 2 BP 97 EP 103 DI 10.1097/PCC.0000000000000358 PG 7 WC Critical Care Medicine; Pediatrics SC General & Internal Medicine; Pediatrics GA CB1KZ UT WOS:000349387600006 PM 25647119 ER PT J AU Mitchell, RM Whitlock, RH Grohn, YT Schukken, YH AF Mitchell, Rebecca M. Whitlock, Robert H. Groehn, Yrjoe T. Schukken, Ynte H. TI Back to the real world: Connecting models with data SO PREVENTIVE VETERINARY MEDICINE LA English DT Article DE Mathematical modeling; Observational studies; Mycobacterium avium subspecies; paratuberculosis ID AVIUM SUBSP PARATUBERCULOSIS; JOHNES-DISEASE CONTROL; INFECTED DAIRY HERDS; SIMULATION-MODEL; CONTROL PROGRAM; UNITED-STATES; TRANSMISSION; CATTLE; METAANALYSIS; CALVES AB Mathematical models for infectious disease are often used to improve our understanding of infection biology or to evaluate the potential efficacy of intervention programs. Here, we develop a mathematical model that aims to describe infection dynamics of Mycobacterium avium subspecies para tuberculosis (MAP). The model was developed using current knowledge of infection biology and also includes some components of MAP infection dynamics that are currently still hypothetical. The objective was to show methods for parameter estimation of state transition models and to connect simulation models with detailed real life data. Thereby making model predictions and results of simulations more reflective and predictive of real world situations. Longitudinal field data from a large observational study are used to estimate parameter values. It is shown that precise data, including molecular diagnostics on the obtained MAP strains, results in more precise and realistic parameter estimates. It is argued that modeling of infection disease dynamics is of great value to understand the patho-biology, epidemiology and control of infectious diseases. The quality of conclusions drawn from model studies depend on two key issues; first, the quality of biology that has gone in the process of developing the model structure; second the quality of the data that go into the estimation of the parameters and the quality and quantity of the data that go into model validation. The more real world data that are used in the model building process, the more likely that modeling studies will provide novel, innovative and valid results. (C) 2014 Elsevier B.V. All rights reserved. C1 [Mitchell, Rebecca M.; Groehn, Yrjoe T.; Schukken, Ynte H.] Cornell Univ, Dept Populat Med & Diagnost Sci, Ithaca, NY 14853 USA. [Mitchell, Rebecca M.] Ctr Dis Control & Prevent, Div Parasitol & Malaria, Atlanta, GA USA. [Whitlock, Robert H.] Univ Penn, New Bolton Ctr, Kennett Sq, PA USA. [Schukken, Ynte H.] GD Anim Hlth, NL-7418 EZ Deventer, Netherlands. RP Schukken, YH (reprint author), GD Anim Hlth, Arnsbergstr 7, NL-7418 EZ Deventer, Netherlands. EM y.schukken@gdanimalhealth.com OI Schukken, Ynte/0000-0002-8250-4194 NR 34 TC 7 Z9 7 U1 3 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-5877 EI 1873-1716 J9 PREV VET MED JI Prev. Vet. Med. PD FEB 1 PY 2015 VL 118 IS 2-3 SI SI BP 215 EP 225 DI 10.1016/j.prevetmed.2014.12.009 PG 11 WC Veterinary Sciences SC Veterinary Sciences GA CB3CH UT WOS:000349505300005 PM 25583453 ER PT J AU Achee, NL Youngblood, L Bangs, MJ Lavery, JV James, S AF Achee, Nicole L. Youngblood, Laura Bangs, Michael J. Lavery, James V. James, Stephanie TI Considerations for the Use of Human Participants in Vector Biology Research: A Tool for Investigators and Regulators SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Review DE Vector; Epidemiology; Risk assessment; Vector control; Entomology ID HUMAN LANDING CATCHES; REED ARMY INSTITUTE; ANOPHELES-GAMBIAE; COMPARATIVE SUSCEPTIBILITY; MALARIA TRANSMISSION; DIPTERA-CULICIDAE; INFECTION; AFRICAN; MODEL; MOSQUITOS AB A thorough search of the existing literature has revealed that there are currently no published recommendations or guidelines for the interpretation of US regulations on the use of human participants in vector biology research (VBR). An informal survey of vector biologists has indicated that issues related to human participation in vector research have been largely debated by academic, national, and local Institutional Review Boards (IRBs) in the countries where the research is being conducted, and that interpretations and subsequent requirements made by these IRBs have varied widely. This document is intended to provide investigators and corresponding scientific and ethical review committee members an introduction to VBR methods involving human participation and the legal and ethical framework in which such studies are conducted with a focus on US Federal Regulations. It is also intended to provide a common perspective for guiding researchers, IRB members, and other interested parties (i.e., public health officials conducting routine entomological surveillance) in the interpretation of human subjects regulations pertaining to VBR. C1 [Achee, Nicole L.] Univ Notre Dame, Dept Biol Sci, Eck Inst Global Hlth, Notre Dame, IN 46556 USA. [Youngblood, Laura] Ctr Dis Control & Prevent, Atlanta, GA USA. [Bangs, Michael J.] Int SOS, Publ Hlth & Malaria Control, Papua, Indonesia. [Lavery, James V.] St Michaels Hosp, Li Ka Shing Knowledge Inst, Ctr Eth Social & Cultural Risk, Toronto, ON M5B 1W8, Canada. [Lavery, James V.] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON M5S 1A1, Canada. [Lavery, James V.] Univ Toronto, Joint Ctr Bioeth, Toronto, ON M5S 1A1, Canada. [James, Stephanie] Fdn Natl Inst Hlth, Bethesda, MD USA. RP Achee, NL (reprint author), Univ Notre Dame, Dept Biol Sci, Eck Inst Global Hlth, 239 Galvin Life Sci Ctr, Notre Dame, IN 46556 USA. EM nachee@nd.edu NR 75 TC 4 Z9 4 U1 1 U2 8 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 EI 1557-7759 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD FEB 1 PY 2015 VL 15 IS 2 BP 89 EP 102 DI 10.1089/vbz.2014.1628 PG 14 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CB5QL UT WOS:000349682500002 PM 25700039 ER PT J AU Healy, JM Reisen, WK Kramer, VL Fischer, M Lindsey, NP Nasci, RS Macedo, PA White, G Takahashi, R Khang, L Barker, CM AF Healy, Jessica M. Reisen, William K. Kramer, Vicki L. Fischer, Marc Lindsey, Nicole P. Nasci, Roger S. Macedo, Paula A. White, Gregory Takahashi, Richard Khang, La Barker, Christopher M. TI Comparison of the Efficiency and Cost of West Nile Virus Surveillance Methods in California SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE West Nile virus; California; Surveillance methods; Birds; Cost effectiveness ID CULEX-TARSALIS DIPTERA; MOSQUITOS; TRANSMISSION; CULICIDAE; CHICKENS; EPIDEMIOLOGY; INFECTIONS; PREVENTION; DYNAMICS; PATTERNS AB Surveillance systems for West Nile virus (WNV) combine several methods to determine the location and timing of viral amplification. The value of each surveillance method must be measured against its efficiency and costs to optimize integrated vector management and suppress WNV transmission to the human population. Here we extend previous comparisons of WNV surveillance methods by equitably comparing the most common methods after standardization on the basis of spatial sampling density and costs, and by estimating optimal levels of sampling effort for mosquito traps and sentinel chicken flocks. In general, testing for evidence of viral RNA in mosquitoes and public-reported dead birds resulted in detection of WNV approximately 2-5 weeks earlier than serological monitoring of sentinel chickens at equal spatial sampling density. For a fixed cost, testing of dead birds reported by the public was found to be the most cost effective of the methods, yielding the highest number of positive results per $1000. Increased spatial density of mosquito trapping was associated with more precise estimates of WNV infection prevalence in mosquitoes. Our findings also suggested that the most common chicken flock size of 10 birds could be reduced to six to seven without substantial reductions in timeliness or sensitivity. We conclude that a surveillance system that uses the testing of dead birds reported by the public complemented by strategically timed mosquito and chicken sampling as agency resources allow would detect viral activity efficiently in terms of effort and costs, so long as susceptible bird species that experience a high mortality rate from infection with WNV, such as corvids, are present in the area. C1 [Healy, Jessica M.; Reisen, William K.; Barker, Christopher M.] Univ Calif Davis, Ctr Vectorborne Dis, Dept Pathol Microbiol & Immunol, Davis, CA 95616 USA. [Kramer, Vicki L.] Calif Dept Publ Hlth, Vector Borne Dis Sect, Sacramento, CA USA. [Fischer, Marc; Lindsey, Nicole P.; Nasci, Roger S.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA. [Macedo, Paula A.] Sacramento Yolo Mosquito & Vector Control Dist, Elk Grove, CA USA. [White, Gregory] Coachella Valley Mosquito & Vector Control Dist, Indio, CA USA. [Takahashi, Richard; Khang, La] Kern Mosquito & Vector Control Dist, Bakersfield, CA USA. [Barker, Christopher M.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. RP Barker, CM (reprint author), Univ Calif Davis, Ctr Vector Borne Dis, Davis, CA 95616 USA. EM cmbarker@ucdavis.edu FU California Department of Public Health; US Centers for Disease Control and Prevention; National Institute of Allergy and Infectious Diseases of the National Institutes of Health [F31AII08189]; Research and Policy for Infectious Disease Dynamics (RAPIDD) program of the Science & Technology Directorate, Department of Homeland Security; Fogarty International Center, National Institutes of Health FX We thank the Sacramento-Yolo, Kern, and Coachella Valley Mosquito and Vector Control Districts for their collection of the data used for this research. In particular, we want to add an additional note of appreciation to Richard Takahashi, who conducted enhanced surveillance at Kern MVCD for two years of the study. We also thank Bborie Park for data management, Kerry Padgett and Leslie Foss for their help with dead bird data, and the California Department of Public Health and the US Centers for Disease Control and Prevention for their support and funding, as well as the National Institute of Allergy and Infectious Diseases of the National Institutes of Health for their support of J. Healy under award number F31AII08189. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. C.M. Barker also acknowledges support from the Research and Policy for Infectious Disease Dynamics (RAPIDD) program of the Science & Technology Directorate, Department of Homeland Security and Fogarty International Center, National Institutes of Health. NR 32 TC 4 Z9 4 U1 2 U2 14 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 EI 1557-7759 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD FEB 1 PY 2015 VL 15 IS 2 BP 147 EP 155 DI 10.1089/vbz.2014.1689 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CB5QL UT WOS:000349682500009 PM 25700046 ER PT J AU Gillespie, C Maalouf, J Yuan, KM Cogswell, ME Gunn, JP Levings, J Moshfegh, A Ahuja, JKC Merritt, R AF Gillespie, Cathleen Maalouf, Joyce Yuan, Keming Cogswell, Mary E. Gunn, Janelle P. Levings, Jessica Moshfegh, Alanna Ahuja, Jaspreet K. C. Merritt, Robert TI Sodium content in major brands of US packaged foods, 2009 SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article DE nutrition; packaged foods; sodium; diet; food ID PROCESSED FOODS; DIETARY-SODIUM; BLOOD-PRESSURE; UNITED-STATES; NEW-ZEALAND; DASH DIET; REDUCTION; PATTERNS; CONSUMPTION AB Background: Most Americans consume more sodium than is recommended, the vast majority of which comes from commercially packaged and restaurant foods. In 2010 the Institute of Medicine recommended that manufacturers reduce the amount of sodium in their products. Objective: The aim was to assess the sodium content in commercially packaged food products sold in US grocery stores in 2009. Design: With the use of sales and nutrition data from commercial sources, we created a database with nearly 8000 packaged food products sold in major US grocery stores in 2009. We estimated the sales-weighted mean and distribution of sodium content (mg/serving, mg/100 g, and mg/kcal) of foods within food groups that contribute the most dietary sodium to the US diet. We estimated the proportion of products within each category that exceed 1) the Food and Drug Administration's (FDA's) limits for sodium in foods that use a "healthy" label claim and 2) 1150 mg/serving or 50% of the maximum daily intake recommended in the 2010 Dietary Guidelines for Americans. Results: Products in the meat mixed dishes category had the highest mean and median sodium contents per serving (966 and 970 mg, respectively). Products in the salad dressing and vegetable oils category had the highest mean and median concentrations per 100 g (1072 and 1067 mg, respectively). Sodium density was highest in the soup category (18.4 mg/kcal). More than half of the products sold in 11 of the 20 food categories analyzed exceeded the FDA limits for products with a "healthy" label claim. In 4 categories, >10% of the products sold exceeded 1150 mg/serving. Conclusions: The sodium content in packaged foods sold in major US grocery stores varied widely, and a large proportion of top-selling products exceeded limits, indicating the potential for reduction. Ongoing monitoring is necessary to evaluate the progress in sodium reduction. C1 [Gillespie, Cathleen; Maalouf, Joyce; Yuan, Keming; Cogswell, Mary E.; Gunn, Janelle P.; Levings, Jessica; Merritt, Robert] CDC, Div Heart Dis & Stroke Prevent, Atlanta, GA 30333 USA. [Moshfegh, Alanna; Ahuja, Jaspreet K. C.] USDA ARS, Beltsville, MD USA. RP Gillespie, C (reprint author), Ctr Dis Control & Prevent, Mailstop F-72,4770 Buford Highway NE, Atlanta, GA 30341 USA. EM cgillespie@cdc.gov FU CDC FX Supported by the CDC. NR 27 TC 5 Z9 5 U1 6 U2 16 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0002-9165 EI 1938-3207 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD FEB PY 2015 VL 101 IS 2 BP 344 EP 353 DI 10.3945/ajcn.113.078980 PG 10 WC Nutrition & Dietetics SC Nutrition & Dietetics GA CA5US UT WOS:000348973900014 PM 25646332 ER PT J AU Mercado, CI Cogswell, ME Valderrama, AL Wang, CY Loria, CM Moshfegh, AJ Rhodes, DG Carriquiry, AL AF Mercado, Carla I. Cogswell, Mary E. Valderrama, Amy L. Wang, Chia-Yih Loria, Catherine M. Moshfegh, Alanna J. Rhodes, Donna G. Carriquiry, Alicia L. TI Difference between 24-h diet recall and urine excretion for assessing population sodium and potassium intake in adults aged 18-39 y SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article DE biomarker; diet; sodium; urine; validation study ID CHRONIC KIDNEY-DISEASE; BLOOD-PRESSURE; H RECALLS; CARDIOVASCULAR RISK; RACIAL-DIFFERENCES; CALCIUM INTAKE; FOOD-INTAKE; VALIDATION; BALANCE; COLLECTION AB Background: Limited data are available on the accuracy of 24-h dietary recalls used to monitor US sodium and potassium intakes. Objective: We examined the difference in usual sodium and potassium intakes estimated from 24-h dietary recalls and urine collections. Design: We used data from a cross-sectional study in 402 participants aged 18-39 y (similar to 50% African American) in the Washington, DC, metropolitan area in 2011. We estimated means and percentiles of usual intakes of daily dietary sodium (dNa) and potassium (dK) and 24-h urine excretion of sodium (uNa) and potassium (uK). We examined Spearman's correlations and differences between estimates from dietary and urine measures. Multiple linear regressions were used to evaluate the factors associated with the difference between dietary and urine measures. Results: Mean differences between diet and urine estimates were higher in men [dNa uNa (95% CI) = 936.8 (787.1, 1086.5) mg/d and dK - uK = 571.3 (448.3, 694.3) mg/d] than in women [dNa uNa (95% CI) = 108.3 (11.1, 205.4) mg/d and dK uK = 163.4 (85.3, 241.5 mg/d)]. Percentile distributions of diet and urine estimates for sodium and potassium differed for men. Spearman's correlations between measures were 0.16 for men and 0.25 for women for sodium and 0.39 for men and 0.29 for women for potassium. Urinary creatinine, total caloric intake, and percentages of nutrient intake from mixed dishes were independently and consistently associated with the differences between diet and urine estimates of sodium and potassium intake. For men, body mass index was also associated. Race was associated with differences in estimates of potassium intake. Conclusions: Low correlations and differences between dietary and urinary sodium or potassium may be due to measurement error in one or both estimates. Future analyses using these methods to assess sodium and potassium intake in relation to health outcomes may consider stratifying by factors associated with the differences in estimates from these methods. This trial was registered at clinicaltrials.gov as NCT01631240. C1 [Mercado, Carla I.; Cogswell, Mary E.; Valderrama, Amy L.] Ctr Dis Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Heart Dis & Stroke Prevent, Atlanta, GA 30333 USA. [Wang, Chia-Yih] Natl Ctr Hlth Stat, Div Hlth & Nutr Examinat Surveys, Hyattsville, MD 20782 USA. [Loria, Catherine M.] NHLBI, Ctr Dis Control & Prevent, NIH, Bethesda, MD 20892 USA. [Moshfegh, Alanna J.; Rhodes, Donna G.] USDA ARS, Beltsville Human Nutr Res Ctr, Beltsville, MD USA. [Carriquiry, Alicia L.] Iowa State Univ, Dept Stat, Ames, IA USA. RP Mercado, CI (reprint author), Ctr Dis Control & Prevent, Mailstop F-72,4770 Buford Highway NE, Atlanta, GA 30341 USA. EM cmercado@cdc.gov FU CDC FX Data collection and laboratory analyses were funded by the CDC. NR 52 TC 8 Z9 8 U1 7 U2 11 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0002-9165 EI 1938-3207 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD FEB PY 2015 VL 101 IS 2 BP 376 EP 386 DI 10.3945/ajcn.113.081604 PG 11 WC Nutrition & Dietetics SC Nutrition & Dietetics GA CA5US UT WOS:000348973900018 PM 25646336 ER PT J AU Blair, A Hines, CJ Thomas, KW Alavanja, MCR Freeman, LEB Hoppin, JA Kamel, F Lynch, CF Lubin, JH Silverman, DT Whelan, E Zahm, SH Sandler, DP AF Blair, A. Hines, C. J. Thomas, K. W. Alavanja, M. C. R. Freeman, L. E. Beane Hoppin, J. A. Kamel, F. Lynch, C. F. Lubin, J. H. Silverman, D. T. Whelan, E. Zahm, S. H. Sandler, D. P. TI Investing in Prospective Cohorts for Etiologic Study of Occupational Exposures SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE LA English DT Editorial Material DE prospective cohorts; agricultural exposures; occupational epidemiology ID NON-HODGKINS-LYMPHOMA; LICENSED PESTICIDE APPLICATORS; SOFT-TISSUE SARCOMA; AGRICULTURAL RISK-FACTORS; BREAST-CANCER RISK; UNITED-STATES; PROSTATE-CANCER; DIESEL EXHAUST; IOWA FARMERS; LUNG-CANCER AB Prospective cohorts have played a major role in understanding the contribution of diet, physical activity, medical conditions, and genes to the development of many diseases, but have not been widely used for occupational exposures. Studies in agriculture are an exception. We draw upon our experience using this design to study agricultural workers to identify conditions that might foster use of prospective cohorts to study other occupational settings. Prospective cohort studies are perceived by many as the strongest epidemiologic design. It allows updating of information on exposure and other factors, collection of biologic samples before disease diagnosis for biomarker studies, assessment of effect modification by genes, lifestyle, and other occupational exposures, and evaluation of a wide range of health outcomes. Increased use of prospective cohorts would be beneficial in identifying hazardous exposures in the workplace. Occupational epidemiologists should seek opportunities to initiate prospective cohorts to investigate high priority, occupational exposures. Am. J. Ind. Med. 58:113-122, 2015. (c) 2015 Wiley Periodicals, Inc. C1 [Blair, A.; Alavanja, M. C. R.; Freeman, L. E. Beane; Lubin, J. H.; Silverman, D. T.; Zahm, S. H.] NCI, Div Epidemiol & Genet, Rockville, MD 20892 USA. [Hines, C. J.; Whelan, E.] NIOSH, Cincinnati, OH 45226 USA. [Thomas, K. W.] US EPA, Natl Exposure Res Lab, Raleigh, NC USA. [Hoppin, J. A.] N Carolina State Univ, Dept Biol Sci, Raleigh, NC 27695 USA. [Kamel, F.; Sandler, D. P.] NIEHS, Epidemiol Branch, Res Triangle Pk, NC USA. [Lynch, C. F.] Univ Iowa, Coll Publ Hlth, Iowa City, IA USA. RP Blair, A (reprint author), NCI, 9609 Med Ctr Dr, Rockville, MD 20892 USA. EM blaira@mail.nih.gov OI Sandler, Dale/0000-0002-6776-0018 FU Intramural CDC HHS [CC999999]; Intramural NIH HHS NR 120 TC 1 Z9 1 U1 3 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0271-3586 EI 1097-0274 J9 AM J IND MED JI Am. J. Ind. Med. PD FEB PY 2015 VL 58 IS 2 BP 113 EP 122 DI 10.1002/ajim.22403 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ9UW UT WOS:000348563100001 PM 25603935 ER PT J AU Robinson, CF Walker, JT Sweeney, MH Shen, R Calvert, GM Schumacher, PK Ju, J Nowlin, S AF Robinson, Cynthia F. Walker, James T. Sweeney, Marie H. Shen, Rui Calvert, Geoffrey M. Schumacher, Pam K. Ju, Jun Nowlin, Susan TI Overview of the National Occupational Mortality Surveillance (NOMS) System: Leukemia and Acute Myocardial Infarction Risk by Industry and Occupation in 30 US States 1985-1999, 2003-2004, and 2007 SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE LA English DT Article DE occupational mortality; surveillance; occupational cancer; occupational heart disease; leukemia; acute myocardial infarction ID NON-HODGKINS-LYMPHOMA; ISCHEMIC-HEART-DISEASE; PROPORTIONATE MORTALITY; UNITED-STATES; AGRICULTURAL HEALTH; SOCIOECONOMIC-STATUS; ELECTRICAL WORKERS; NORDIC COUNTRIES; LUNG-CANCER; RATIO AB BackgroundCancer and chronic disease are leading causes of death in the US with an estimated cost of $46 billion. MethodsWe analyzed 11 million cause-specific deaths of US workers age 18-64 years in 30 states during 1985-1999, 2003-2004, and 2007 by occupation, industry, race, gender, and Hispanic origin. ResultsThe highest significantly elevated proportionate leukemia mortality was observed in engineers, protective service, and advertising sales manager occupations and in banks/savings &loans/credit agencies, public safety, and public administration industries. The highest significantly elevated smoking-adjusted acute myocardial infarction mortality was noted in industrial and refractory machinery mechanics, farmers, mining machine operators, and agricultural worker occupations; and wholesale farm supplies, agricultural chemical, synthetic rubber, and agricultural crop industries. ConclusionsSignificantly elevated risks for acute myocardial infarction and leukemia were observed across several occupations and industries that confirm existing reports and add new information. Interested investigators can access the NOMS website at . Am. J. Ind. Med. 58:123-137, 2015. (c) 2015 Wiley Periodicals, Inc. C1 [Robinson, Cynthia F.; Walker, James T.; Sweeney, Marie H.; Calvert, Geoffrey M.; Schumacher, Pam K.; Ju, Jun; Nowlin, Susan] NIOSH, Ctr Dis Control & Prevent, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH 45226 USA. [Shen, Rui] SRA Int, Fairfax, VA USA. RP Robinson, CF (reprint author), NIOSH, Div Surveillance Hazard Evaluat & Field Studies, MS R-18,4676 Columbia Pkwy, Cincinnati, OH 45226 USA. EM cfr2@cdc.gov FU National Institute for Occupational Safety and Health FX We thank the State Offices of Vital Statistics and Public Health for providing the data for the study. States who provided industry, occupation and mortality data were Alaska, Colorado, Georgia, Hawaii, Idaho, Indiana, Kansas, Kentucky, Maine, Michigan, Missouri, Nebraska, Nevada, New Hampshire, NewJersey, New Mexico, New York, North Dakota, NorthCarolina, Oklahoma, Pennsylvania, Ohio, Rhode Island, South Carolina, Texas, Tennessee, Utah, Vermont, Washington, West Virginia, and Wisconsin. The contributions of Dr. Rajesh Virkar, Mr. Delton Atkinson, Ms. Chrissy Jarmin, Dr. Bob Anderson, the state agents, and others at NCHS; the State Vital Statistics Departments; the funeral homes, medical examiners, and coroners, the National Cancer Institute, the US Census, and the National Association of Public Health Statisticians (NAPHSIS) are gratefully acknowledged. Without collaboration between NIOSH, NCHS, NAPHSIS, and the US State Vital Statistics Departments, it would not have been possible to conduct the NOMS study. This work was supported by the National Institute for Occupational Safety and Health. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institute for Occupational Safety and Health (NIOSH). NR 88 TC 3 Z9 3 U1 0 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0271-3586 EI 1097-0274 J9 AM J IND MED JI Am. J. Ind. Med. PD FEB PY 2015 VL 58 IS 2 BP 123 EP 137 DI 10.1002/ajim.22408 PG 15 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ9UW UT WOS:000348563100002 PM 25603936 ER PT J AU Sokolow, LZ Naleway, AL Li, DK Shifflett, P Reynolds, S Henninger, ML Ferber, JR Odouli, R Irving, SA Thompson, MG AF Sokolow, Leslie Z. Naleway, Allison L. Li, De-Kun Shifflett, Pat Reynolds, Sue Henninger, Michelle L. Ferber, Jeannette R. Odouli, Roxana Irving, Stephanie A. Thompson, Mark G. CA Pregnancy Influenza Project Workgr TI Severity of influenza and noninfluenza acute respiratory illness among pregnant women, 2010-2012 SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE acute respiratory illness; illness severity; influenza; influenza vaccine; pregnancy ID SEASON; OUTCOMES; HOSPITALIZATIONS; METAANALYSIS; POPULATION; INFECTIONS; FEVER AB OBJECTIVE: The objective of the study was to identify characteristics of influenza illness contrasted with noninfluenza acute respiratory illness ( ARI) in pregnant women. STUDY DESIGN: ARI among pregnant women was identified through daily surveillance during 2 influenza seasons ( 2010- 2012). Within 8 days of illness onset, nasopharyngeal swabs were collected, and an interview was conducted for symptoms and other characteristics. A follow- up telephone interview was conducted 1- 2 weeks later, and medical records were extracted. Severity of illness was evaluated by self- assessment of 12 illness symptoms, subjective ratings of overall impairment, highest reported temperature, illness duration, and medical utilization. RESULTS: Of 292 pregnant women with ARI, 100 tested positive for influenza viruses. Women with influenza illnesses reported higher symptom severity than those with noninfluenza ARI ( median score, 18 vs 16 of 36; P <.05) and were more likely to report severe subjective feverishness ( 18% vs 5%; P <.001), myalgia ( 28% vs 14%; P <.005), cough ( 46% vs 30%; P <.01), and chills ( 25% vs 13%; P <.01). More influenza illnesses were associated with fever greater than 38.9 C ( 20% vs 5%; P<. 001) and higher subjective impairment ( mean score, 5.9 vs 4.8; P <.001). Differences in overall symptom severity, fever, cough, chills, early health careeseeking behavior, and impairment remained significant in multivariate models after adjusting for study site, season, age, vaccination status, and number of days since illness onset. CONCLUSION: Influenza had a greater negative impact on pregnant women than noninfluenza ARIs, as indicated by symptom severity and greater likelihood of elevated temperature. These results highlight the importance of preventing and treating influenza illnesses in pregnant women. C1 [Sokolow, Leslie Z.; Reynolds, Sue; Thompson, Mark G.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA. [Sokolow, Leslie Z.] Battelle Mem Inst, Atlanta, GA USA. [Naleway, Allison L.; Henninger, Michelle L.; Irving, Stephanie A.] Kaiser Permanente Northwest, Ctr Hlth Res, Portland, OR USA. [Li, De-Kun; Ferber, Jeannette R.; Odouli, Roxana] Kaiser Fdn Res Inst, Div Res, Oakland, CA USA. [Li, De-Kun] Stanford Univ, Sch Med, Dept Hlth Res & Policy, Palo Alto, CA 94304 USA. [Shifflett, Pat] Abt Associates Inc, Cambridge, MA USA. RP Sokolow, LZ (reprint author), Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA. EM lsokolow@cdc.gov FU PHS HHS [200-2010-F-33132] NR 20 TC 4 Z9 4 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 EI 1097-6868 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD FEB PY 2015 VL 212 IS 2 AR 202.e1 DI 10.1016/j.ajog.2014.08.004 PG 11 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA CA1IH UT WOS:000348665500020 PM 25111585 ER PT J AU Zapata, LB Murtaza, S Whiteman, MK Jamieson, DJ Robbins, CL Marchbanks, PA D'Angelo, DV Curtis, KM AF Zapata, Lauren B. Murtaza, Sarah Whiteman, Maura K. Jamieson, Denise J. Robbins, Cheryl L. Marchbanks, Polly A. D'Angelo, Denise V. Curtis, Kathryn M. TI Contraceptive counseling and postpartum contraceptive use SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE contraception; contraceptive counseling; postpartum period; prenatal care ID ASSESSMENT MONITORING-SYSTEM; UNITED-STATES; UNINTENDED PREGNANCY; RISK; RECOMMENDATIONS; POPULATION; OUTCOMES; INFANT; HEALTH; PRAMS AB OBJECTIVE: The objective of the study was to examine the associations between prenatal and postpartum contraceptive counseling and postpartum contraceptive use. STUDY DESIGN: The Pregnancy Risk Assessment Monitoring System 2004e2008 data were analyzed from Missouri, New York state, and New York City (n = 9536). We used multivariable logistic regression to assess the associations between prenatal and postpartum contraceptive counseling and postpartum contraceptive use, defined as any method and more effective methods (sterilization, intrauterine device, or hormonal methods). RESULTS: The majority of women received prenatal (78%) and postpartum (86%) contraceptive counseling; 72% received both. Compared with those who received no counseling, those counseled during 1 time period (adjusted odds ratio [AOR], 2.10; 95% confidence interval [CI], 1.65-2.67) and both time periods (AOR, 2.33; 95% CI, 1.87-2.89) had significantly increased odds of postpartum use of a more effective contraceptive method (32% vs 49% and 56%, respectively; P for trend <.0001). Results for counseling during both time periods differed by type of health insurance before pregnancy, with greater odds of postpartum use of a more effective method observed for women with no insurance (AOR, 3.51; 95% CI, 2.18-5.66) and Medicaid insurance (AOR, 3.74; 95% CI, 1.98-7.06) than for those with private insurance (AOR, 1.87; 95% CI, 1.44-2.43) before pregnancy. Findings were similar for postpartum use of any contraceptive method, except that no differences by insurance status were detected. CONCLUSION: The prevalence of postpartum contraceptive use, including the use of more effective methods, was highest when contraceptive counseling was provided during both prenatal and postpartum time periods. Women with Medicaid or no health insurance before pregnancy benefited the most. C1 [Zapata, Lauren B.; Murtaza, Sarah; Whiteman, Maura K.; Jamieson, Denise J.; Robbins, Cheryl L.; Marchbanks, Polly A.; D'Angelo, Denise V.; Curtis, Kathryn M.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Chamblee, GA 30329 USA. RP Zapata, LB (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Chamblee, GA 30329 USA. EM lzapata@cdc.gov FU Intramural CDC HHS [CC999999] NR 30 TC 4 Z9 4 U1 0 U2 4 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 EI 1097-6868 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD FEB PY 2015 VL 212 IS 2 AR 171.e1 DI 10.1016/j.ajog.2014.07.059 PG 8 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA CA1IH UT WOS:000348665500008 PM 25093946 ER PT J AU Klompas, M Anderson, D Trick, W Babcock, H Kerlin, MP Li, LL Sinkowitz-Cochran, R Ely, EW Jernigan, J Magill, S Lyles, R O'Neil, C Kitch, BT Arrington, E Balas, MC Kleinman, K Bruce, C Lankiewicz, J Murphy, MV Cox, CE Lautenbach, E Sexton, D Fraser, V Weinstein, RA Platt, R AF Klompas, Michael Anderson, Deverick Trick, William Babcock, Hilary Kerlin, Meeta Prasad Li, Lingling Sinkowitz-Cochran, Ronda Ely, E. Wesley Jernigan, John Magill, Shelley Lyles, Rosie O'Neil, Caroline Kitch, Barrett T. Arrington, Ellen Balas, Michele C. Kleinman, Ken Bruce, Christina Lankiewicz, Julie Murphy, Michael V. Cox, Christopher E. Lautenbach, Ebbing Sexton, Daniel Fraser, Victoria Weinstein, Robert A. Platt, Richard CA CDC Prevention Epictr TI The Preventability of Ventilator-associated Events The CDC Prevention Epicenters Wake Up and Breathe Collaborative SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Article DE ventilator-associated events; quality improvement; surveillance ID CRITICALLY-ILL PATIENTS; RANDOMIZED CONTROLLED-TRIAL; INTENSIVE-CARE UNITS; MECHANICAL VENTILATION; SEDATION; SURVEILLANCE; PNEUMONIA; PROTOCOL; IMPACT; SAFETY AB Rationale: The CDC introduced ventilator-associated event (VAE) definitions in January2013. Little is known about VAE prevention. We hypothesized that daily, coordinated spontaneous awakening trials (SATs) and spontaneous breathing trials (SBTs) might prevent VAEs. Objectives: To assess the preventability of VAEs. Methods: We nested a multicenter quality improvement collaborative within a prospective study of VAE surveillance among 20 intensive care units between November 2011 and May 2013. Twelve units joined the collaborative and implemented an opt-out protocol for nurses and respiratory therapists to perform paired daily SATs and SBTs. The remaining eight units conducted surveillance alone. We measured temporal trends in VAEs using generalized mixed effects regression models adjusted for patient-level unit, age, sex, reason for intubation, Sequential Organ Failure Assessment score, and comorbidity index. Measurements and Main Results: We tracked 5,164 consecutive episodes of mechanical ventilation: 3,425 in collaborative units and 1,739 in surveillance-only units. Within collaborative units, significant increases in SATs, SBTs, and percentage of SBTs performed without sedation were mirrored by Significant decreases in duration of mechanical ventilation and hospital length-of-stay. There was no change in VAE risk per ventilator day but significant decreases in VAE risk per episode of mechanical ventilation (odds ratio [OR] 0.63; 95% confidence interval [CI], 0.42-0.97) and infection-related Ventilator-associated complications (OR, 0.35; 95% CI, 0.17-0.71) but not pneumonias (OR, 0.51; 95% CI, 0.19-1.3). Within surveillance-only units, there were no significant changes in SAT, SBT or VAE rates. Conclusions: Enhanced performance of paired, daily SATs and SBTs is associated with lower VAE rates. C1 [Klompas, Michael; Li, Lingling; Kleinman, Ken; Bruce, Christina; Lankiewicz, Julie; Murphy, Michael V.; Platt, Richard] Harvard Univ, Sch Med, Dept Populat Med, Boston, MA 02215 USA. [Klompas, Michael; Li, Lingling; Kleinman, Ken; Bruce, Christina; Lankiewicz, Julie; Murphy, Michael V.; Platt, Richard] Harvard Pilgrim Healthcare Inst, Boston, MA USA. [Klompas, Michael; Platt, Richard] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA. [Anderson, Deverick; Cox, Christopher E.; Sexton, Daniel] Duke Univ, Dept Med, Durham, NC USA. [Trick, William; Lyles, Rosie] Cook Cty Hlth & Hosp Syst, Collaborat Res Unit, Chicago, IL USA. [Babcock, Hilary; O'Neil, Caroline; Fraser, Victoria] Washington Univ, Dept Med, St Louis, MO USA. [Kerlin, Meeta Prasad; Lautenbach, Ebbing] Univ Penn, Dept Med, Philadelphia, PA 19104 USA. [Sinkowitz-Cochran, Ronda; Jernigan, John; Magill, Shelley] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA. [Ely, E. Wesley] Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37212 USA. [Ely, E. Wesley] Tennessee Valley Vet Affairs Healthcare Syst, Geriatr Res Educ & Clin Ctr, Nashville, TN USA. [Kitch, Barrett T.; Arrington, Ellen] North Shore Med Ctr, Dept Med, Salem, MA USA. [Balas, Michele C.] Ohio State Univ, Ctr Crit & Complex Care, Columbus, OH 43210 USA. [Weinstein, Robert A.] Cook Cty Hlth & Hosp Syst, Dept Med, Chicago, IL USA. [Weinstein, Robert A.] Rush Med Coll, Chicago, IL 60612 USA. RP Klompas, M (reprint author), Dept Populat Med, 133 Brookline Ave,6th Floor, Boston, MA 02215 USA. EM mklompas@partners.org RI Balas, Michele/C-6683-2014 FU Centers for Disease Control and Prevention [3 U54CK000172-01S1] FX Supported by the Centers for Disease Control and Prevention (grant #3 U54CK000172-01S1). NR 40 TC 42 Z9 42 U1 1 U2 9 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PD FEB 1 PY 2015 VL 191 IS 3 BP 292 EP 301 DI 10.1164/rccm.201407-1394OC PG 10 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA CA3SS UT WOS:000348827000013 PM 25369558 ER PT J AU Dorman, SE Savic, RM Goldberg, S Stout, JE Schluger, N Muzanyi, G Johnson, JL Nahid, P Hecker, EJ Heilig, CM Bozeman, L Feng, PJI Moro, RN MacKenzie, W Dooley, KE Nuermberger, EL Vernon, A Weiner, M AF Dorman, Susan E. Savic, Radojka M. Goldberg, Stefan Stout, Jason E. Schluger, Neil Muzanyi, Grace Johnson, John L. Nahid, Payam Hecker, Emily J. Heilig, Charles M. Bozeman, Lorna Feng, Pei-Jean I. Moro, Ruth N. MacKenzie, William Dooley, Kelly E. Nuermberger, Eric L. Vernon, Andrew Weiner, Marc CA TB Trials Consortium TI Daily Rifapentine for Treatment of Pulmonary Tuberculosis A Randomized, Dose-Ranging Trial SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Article DE mycobacterium; rifamycins; rifapentine; therapeutics; tuberculosis ID EARLY BACTERICIDAL ACTIVITY; INTENSIVE PHASE TREATMENT; SHORT-COURSE CHEMOTHERAPY; POPULATION PHARMACOKINETICS; MYCOBACTERIUM-TUBERCULOSIS; HEALTHY-VOLUNTEERS; RIFAMPIN; MOXIFLOXACIN; REGIMENS; SINGLE AB Rationale: Rifapentine has potent activity in mouse models of tuberculosis chemotherapy but its optimal dose and exposure in humans are unknown. Objectives: We conducted a randomized, partially blinded dose-ranging study to determine tolerability, safety, and antimicrobial activity of daily rifapentine for pulmonary tuberculosis treatment. Methods: Adults with sputum smear-positive pulmonary tuberculosis were assigned rifapentine 10, 15, or 20 mg/kg or rifampin 10 mg/kg daily for 8 weeks (intensive phase), with isoniazid, pyrazinamide, and ethambutol. The primary tolerability end point was treatment discontinuation. The primary efficacy end point was negative sputum cultures at completion of intensive phase. Measurements and Main Results: A total of 334 participants were enrolled. At completion of intensive phase, cultures on solid media were negative in 81.3% of participants in the rifampin group versus 92.5% (P = 0.097), 89.4% (P = 0.29), and 94.7% (P = 0.049) in the rifapentine 10, 15, and 20 mg/kg groups. Liquid cultures were negative in 56.3% (rifampin group) versus 74.6% (P = 0.042), 69.7% (P = 0.16), and 82.5% (P = 0.004), respectively. Compared with the rifampin group, the proportion negative at the end of intensive phase was higher among rifapentine recipients who had high rifapentine areas under the concentration-time curve. Percentages of participants discontinuing assigned treatment for reasons other than microbiologic ineligibility were similar across groups (rifampin, 8.2%; rifapentine 10, 15, or 20 mg/kg, 3.4, 2.5, and 7.4%, respectively). Conclusions: Daily rifapentine was well-tolerated and safe. High rifapentine exposures were associated with high levels of sputum sterilization at completion of intensive phase. Further studies are warranted to determine if regimens that deliver high rifapentine exposures can shorten treatment duration to less than 6 months. C1 [Dorman, Susan E.; Dooley, Kelly E.; Nuermberger, Eric L.] Johns Hopkins Univ, Sch Med, Baltimore, MD 21231 USA. [Savic, Radojka M.; Nahid, Payam] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Goldberg, Stefan; Heilig, Charles M.; Bozeman, Lorna; Feng, Pei-Jean I.; Moro, Ruth N.; MacKenzie, William; Vernon, Andrew] Ctr Dis Control & Prevent, Atlanta, GA USA. [Stout, Jason E.; Hecker, Emily J.] Duke Univ, Sch Med, Durham, NC USA. [Schluger, Neil] Columbia Univ, Med Ctr, New York, NY USA. [Muzanyi, Grace; Johnson, John L.] Uganda Case Western Reserve Univ Res Collaborat, Kampala, Uganda. [Johnson, John L.] Case Western Reserve Univ, Sch Med, Cleveland, OH USA. [Moro, Ruth N.] CDC Fdn Res Collaborat, Atlanta, GA USA. [Weiner, Marc] Univ Texas San Antonio, Hlth Sci Ctr, San Antonio, TX USA. [Weiner, Marc] South Texas VAMC, San Antonio, TX USA. RP Dorman, SE (reprint author), Johns Hopkins Univ, Ctr TB Res, 1550 Orleans St,Room 1M-12, Baltimore, MD 21231 USA. EM dsusan1@jhmi.edu OI Stout, Jason/0000-0002-6698-8176; Heilig, Charles/0000-0003-1075-1310 FU U.S. Government Division of Tuberculosis Elimination, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention FX Supported by the U.S. Government Division of Tuberculosis Elimination, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention. Sanofi donated rifapentine and, rifampin, and since 2007 donated over $1.7 million to the Centers for Disease Control and Prevention Foundation to supplement available U.S. federal funding for rifapentine research; these funds included salary support for R.N.M. NR 47 TC 30 Z9 30 U1 5 U2 14 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PD FEB 1 PY 2015 VL 191 IS 3 BP 333 EP 343 DI 10.1164/rccm.201410-1843OC PG 11 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA CA3SS UT WOS:000348827000018 PM 25489785 ER PT J AU Kirkcaldy, RD Soge, O Papp, JR Hook, EW del Rio, C Kubin, G Weinstock, HS AF Kirkcaldy, Robert D. Soge, Olusegun Papp, John R. Hook, Edward W., III del Rio, Carlos Kubin, Grace Weinstock, Hillard S. TI Analysis of Neisseria gonorrhoeae Azithromycin Susceptibility in the United States by the Gonococcal Isolate Surveillance Project, 2005 to 2013 SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID DISEASES-TREATMENT-GUIDELINES; HIGH-LEVEL RESISTANCE; REDUCED SUSCEPTIBILITY; MACROLIDE RESISTANCE; CAMPYLOBACTER-JEJUNI; NO LONGER; EMERGENCE; INFECTIONS; MUTATIONS; FITNESS AB Azithromycin, administered with ceftriaxone, is recommended by the CDC for the treatment of gonorrhea. Many experts have expressed concern about the ease with which Neisseria gonorrhoeae can acquire macrolide resistance. We sought to describe gonococcal azithromycin susceptibility in the United States and to determine whether azithromycin susceptibility has changed over time. We analyzed data from 2005 to 2013 from the Gonococcal Isolate Surveillance Project, a CDC-supported sentinel surveillance network that monitors gonococcal antimicrobial susceptibility. A total of 44,144 N. gonorrhoeae isolates were tested for azithromycin susceptibility by agar dilution methods. The overall azithromycin MIC50 was 0.25 mu g/ml, and the MIC90 was 0.5 mu g/ml. There were no overall temporal trends in geometric means. Isolates from men who had sex with men had significantly higher geometric mean MICs than isolates from men who had sex exclusively with women. The overall prevalence of reduced azithromycin susceptibility (MIC >= 2 mu g/ml) was 0.4% and varied by year from 0.3% (2006 and 2009) to 0.6% (2013). We did not find a clear temporal trend in gonococcal azithromycin MICs in the United States, and the prevalence of reduced azithromycin susceptibility remains low. These findings support the continued use of azithromycin in a combination therapy regimen for gonorrhea. C1 [Kirkcaldy, Robert D.; Papp, John R.; Weinstock, Hillard S.] US Dept HHS, Div STD Prevent, Ctr Dis Control & Prevent, Atlanta, GA 30303 USA. [Soge, Olusegun] Univ Washington, Seattle, WA 98195 USA. [Hook, Edward W., III] Univ Alabama Birmingham, Birmingham, AL USA. [Hook, Edward W., III] Jefferson Cty Dept Hlth, Birmingham, AL USA. [del Rio, Carlos] Emory Univ, Atlanta, GA 30322 USA. [Kubin, Grace] Texas Dept State Hlth Serv, Austin, TX USA. RP Kirkcaldy, RD (reprint author), US Dept HHS, Div STD Prevent, Ctr Dis Control & Prevent, Atlanta, GA 30303 USA. EM rkirkcaldy@cdc.gov RI del Rio, Carlos/B-3763-2012 OI del Rio, Carlos/0000-0002-0153-3517 FU Centers for Disease Control and Prevention, U.S. Department of Health and Human Services FX The Gonococcal Isolate Surveillance Project is funded by the Centers for Disease Control and Prevention, U.S. Department of Health and Human Services. NR 40 TC 8 Z9 8 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD FEB PY 2015 VL 59 IS 2 BP 998 EP 1003 DI 10.1128/AAC.04337-14 PG 6 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA CA0LT UT WOS:000348610000030 PM 25451056 ER PT J AU Grossman, NT Pham, CD Cleveland, AA Lockhart, SR AF Grossman, Nina T. Pham, Cau D. Cleveland, Angela A. Lockhart, Shawn R. TI Molecular Mechanisms of Fluconazole Resistance in Candida parapsilosis Isolates from a US Surveillance System SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID INTENSIVE-CARE-UNIT; ALBICANS STRAINS; DRUG-RESISTANCE; ANTIFUNGAL AGENTS; AZOLE RESISTANCE; EFFLUX PUMP; MRR1; MUTATIONS; OVEREXPRESSION; MANAGEMENT AB Candida parapsilosis is the second or third most common cause of candidemia in many countries. The Infectious Diseases Society of America recommends fluconazole as the primary therapy for C. parapsilosis candidemia. Although the rate of fluconazole resistance among C. parapsilosis isolates is low in most U.S. institutions, the resistance rate can be as high as 7.5%. This study was designed to assess the mechanisms of fluconazole resistance in 706 incident bloodstream isolates from U.S. hospitals. We sequenced the ERG11 and MRR1 genes of 122 C. parapsilosis isolates with resistant (30 isolates; 4.2%), susceptible dose-dependent (37 isolates; 5.2%), and susceptible (55 isolates) fluconazole MIC values and used real-time PCR of RNA from 17 isolates to investigate the regulation of MDR1. By comparing these isolates to fully fluconazole-susceptible isolates, we detected at least two mechanisms of fluconazole resistance: an amino acid substitution in the 14-alpha-demethylase gene ERG11 and overexpression of the efflux pump MDR1, possibly due to point mutations in the MRR1 transcription factor that regulates MDR1. The ERG11 single nucleotide polymorphism (SNP) was found in 57% of the fluconazole-resistant isolates and in no susceptible isolates. The MRR1 SNPs were more difficult to characterize, as not all resulted in overexpression of MDR1 and not all MDR1 overexpression was associated with an SNP in MRR1. Further work to characterize the MRR1 SNPs and search for overexpression of other efflux pumps is needed. C1 [Grossman, Nina T.; Pham, Cau D.; Cleveland, Angela A.; Lockhart, Shawn R.] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA 30329 USA. RP Lockhart, SR (reprint author), Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA 30329 USA. EM gyi2@cdc.gov FU Centers for Disease Control and Prevention (CDC) FX This research was supported in part by an appointment to the Emerging Infectious Diseases (EID) Fellowship Program administered by the Association of Public Health Laboratories (APHL) and funded by the Centers for Disease Control and Prevention (CDC). NR 29 TC 11 Z9 11 U1 1 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD FEB PY 2015 VL 59 IS 2 BP 1030 EP 1037 DI 10.1128/AAC.04613-14 PG 8 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA CA0LT UT WOS:000348610000034 PM 25451046 ER PT J AU Lehman, SM Donlan, RM AF Lehman, Susan M. Donlan, Rodney M. TI Bacteriophage-Mediated Control of a Two-Species Biofilm Formed by Microorganisms Causing Catheter-Associated Urinary Tract Infections in an In Vitro Urinary Catheter Model SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID CARE-ASSOCIATED INFECTIONS; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA; BACTERIAL INTERFERENCE; ARTIFICIAL URINE; ANTIBIOTIC-RESISTANCE; ANTIMICROBIAL AGENTS; TERM CATHETERIZATION; URETHRAL CATHETER; PROTEUS-MIRABILIS AB Microorganisms from a patient or their environment may colonize indwelling urinary catheters, forming biofilm communities on catheter surfaces and increasing patient morbidity and mortality. This study investigated the effect of pretreating hydrogelcoated silicone catheters with mixtures of Pseudomonas aeruginosa and Proteus mirabilis bacteriophages on the development of single-and two-species biofilms in a multiday continuous-flow in vitro model using artificial urine. Novel phages were purified from sewage, characterized, and screened for their abilities to reduce biofilm development by clinical isolates of their respective hosts. Our screening data showed that artificial urine medium (AUM) is a valid substitute for human urine for the purpose of evaluating uropathogen biofilm control by these bacteriophages. Defined phage cocktails targeting P. aeruginosa and P. mirabilis were designed based on the biofilm inhibition screens. Hydrogel-coated catheters were pretreated with one or both cocktails and challenged with approximately 1 x 10(3) CFU/ml of the corresponding pathogen(s). The biofilm growth on the catheter surfaces in AUM was monitored over 72 to 96 h. Phage pretreatment reduced P. aeruginosa biofilm counts by 4 log(10) CFU/cm(2) (P <= 0.01) and P. mirabilis biofilm counts by > 2 log(10) CFU/cm(2) (P <= 0.01) over 48 h. The presence of P. mirabilis was always associated with an increase in lumen pH from 7.5 to 9.5 and with eventual blockage of the reactor lines. The results of this study suggest that pretreatment of a hydrogel urinary catheter with a phage cocktail can significantly reduce mixed-species biofilm formation by clinically relevant bacteria. C1 [Lehman, Susan M.; Donlan, Rodney M.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. RP Donlan, RM (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. EM rld8@cdc.gov FU American Society for Microbiology/Coordinating Center for Infectious Disease International Postdoctoral Fellowship FX S.M.L. was supported by an American Society for Microbiology/Coordinating Center for Infectious Disease International Postdoctoral Fellowship. NR 70 TC 7 Z9 7 U1 5 U2 32 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD FEB PY 2015 VL 59 IS 2 BP 1127 EP 1137 DI 10.1128/AAC.03786-14 PG 11 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA CA0LT UT WOS:000348610000045 PM 25487795 ER PT J AU Blanck, HM Collins, JL AF Blanck, Heidi M. Collins, Janet L. TI The Childhood Obesity Research Demonstration Project: Linking Public Health Initiatives and Primary Care Interventions Community-Wide To Prevent and Reduce Childhood Obesity SO CHILDHOOD OBESITY LA English DT Editorial Material ID PHYSICAL-ACTIVITY; CHILDREN; POPULATION; STRATEGIES; TRIAL C1 [Blanck, Heidi M.; Collins, Janet L.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Blanck, HM (reprint author), Ctr Dis Control & Prevent, Obes Prevent & Control Branch, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway,F77, Atlanta, GA 30341 USA. EM hcb3@cdc.gov NR 21 TC 3 Z9 3 U1 0 U2 11 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 2153-2168 EI 2153-2176 J9 CHILD OBES JI Child Obes. PD FEB 1 PY 2015 VL 11 IS 1 BP 1 EP 3 DI 10.1089/chi.2014.0122 PG 3 WC Pediatrics SC Pediatrics GA CB0LH UT WOS:000349317000001 PM 25679058 ER PT J AU Foltz, JL Belay, B Dooyema, CA Williams, N Blanck, HM AF Foltz, Jennifer L. Belay, Brook Dooyema, Carrie A. Williams, Nancy Blanck, Heidi M. TI Childhood Obesity Research Demonstration (CORD): The Cross-Site Overview and Opportunities for Interventions Addressing Obesity Community-Wide SO CHILDHOOD OBESITY LA English DT Article ID PREVENTION; OVERWEIGHT; CHILDREN; ADOLESCENTS; ENVIRONMENTS; HEALTH; SCHOOL AB Background: This is the first of a set of articles in this issue on the Childhood Obesity Research Demonstration (CORD) project and provides an overview of the multisite approach and community-wide interventions. Innovative multisetting, multilevel approaches that integrate primary healthcare and public health interventions to improve outcomes for children with obesity need to be evaluated. The CORD project aims to improve BMI and obesity-related behaviors among underserved 2- to 12-year-old children by utilizing these approaches. Methods: The CORD consortium, structure, model terminology and key components, and common measures were solidified in year 1 of the CORD project. Demonstration sites applied the CORD model across communities in years 2 and 3. Evaluation plans for year 4 include site-specific analyses as well as cross-site impact, process, and sustainability evaluations. Results: The CORD approach resulted in commonalities and differences in participant, intervention, comparison, and outcome elements across sites. Products are to include analytic results as well as cost assessment, lessons learned, tools, and materials. Discussion: Foreseen opportunities and challenges arise from the similarities and unique aspects across sites. Communities adapted interventions to fit their local context and build on strengths, but, in turn, this flexibility makes cross-site evaluation challenging. Conclusion: The CORD project represents an evidence-based approach that integrates primary care and public health strategies and evaluates multisetting multilevel interventions, thus adding to the limited research in this field. CORD products will be disseminated to a variety of stakeholders to aid the understanding, prevention, and management of childhood obesity. C1 [Foltz, Jennifer L.; Belay, Brook; Dooyema, Carrie A.; Williams, Nancy; Blanck, Heidi M.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Foltz, Jennifer L.; Williams, Nancy; Blanck, Heidi M.] US Publ Hlth Serv Commissioned Corps, Atlanta, GA USA. RP Foltz, JL (reprint author), Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway Northeast MS F-77, Atlanta, GA 30341 USA. EM jfoltz@cdc.gov NR 31 TC 6 Z9 6 U1 0 U2 4 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 2153-2168 EI 2153-2176 J9 CHILD OBES JI Child Obes. PD FEB 1 PY 2015 VL 11 IS 1 BP 4 EP 10 DI 10.1089/chi.2014.0159 PG 7 WC Pediatrics SC Pediatrics GA CB0LH UT WOS:000349317000002 PM 25679059 ER PT J AU Williams, N Dooyema, CA Foltz, JL Belay, B Blanck, HM AF Williams, Nancy Dooyema, Carrie A. Foltz, Jennifer L. Belay, Brook Blanck, Heidi M. TI The Childhood Obesity Research Demonstration Project: A Team Approach for Supporting a Multisite, Multisector Intervention SO CHILDHOOD OBESITY LA English DT Article ID UNITED-STATES; CHILDREN AB Background: Comprehensive multisector, multilevel approaches are needed to address childhood obesity. This article introduces the structure of a multidisciplinary team approach used to support and guide the multisite, multisector interventions implemented as part of the Childhood Obesity Research Demonstration (CORD) project. This article will describe the function, roles, and lessons learned from the CDC-CORD approach to project management. Methods: The CORD project works across multisectors and multilevels in three demonstration communities. Working with principal investigators and their research teams who are engaging multiple stakeholder groups, including community organizations, schools and child care centers, health departments, and healthcare providers, can be a complex endeavor. To best support the community-based research project, scientific and programmatic expertise in a wide range of areas was required. The team was configured based on the skill sets needed to interact with the various levels of staff working with the project. Conclusions: By thoughtful development of the team and processes, an efficient system for supporting the multisite, multisector intervention project sites was developed. The team approach will be formally evaluated at the end of the project period. C1 [Williams, Nancy; Dooyema, Carrie A.; Foltz, Jennifer L.; Belay, Brook; Blanck, Heidi M.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Williams, Nancy; Foltz, Jennifer L.; Blanck, Heidi M.] US Publ Hlth Serv Commissioned Corps, Atlanta, GA USA. RP Williams, N (reprint author), Ctr Dis Control & Prevent, Obes Prevent & Control Branch, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway,F77, Atlanta, GA 30341 USA. EM ndw6@cdc.gov NR 13 TC 2 Z9 2 U1 1 U2 5 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 2153-2168 EI 2153-2176 J9 CHILD OBES JI Child Obes. PD FEB 1 PY 2015 VL 11 IS 1 BP 104 EP 108 DI 10.1089/chi.2014.0063 PG 5 WC Pediatrics SC Pediatrics GA CB0LH UT WOS:000349317000010 PM 25325835 ER PT J AU Halldin, CN Doney, BC Hnizdo, E AF Halldin, Cara N. Doney, Brent C. Hnizdo, Eva TI Changes in prevalence of chronic obstructive pulmonary disease and asthma in the US population and associated risk factors SO CHRONIC RESPIRATORY DISEASE LA English DT Article DE Chronic bronchitis; emphysema; asthma; occupational exposure; occupational diseases; NHANES ID AFRICAN GOLD MINERS; CHRONIC RESPIRATORY SYMPTOMS; NUTRITION-EXAMINATION-SURVEY; ADULT-ONSET ASTHMA; BODY-MASS INDEX; NHANES-III DATA; LUNG-FUNCTION; COAL-WORKERS; CHRONIC-BRONCHITIS; DUST EXPOSURE AB Chronic lower airway diseases, including chronic obstructive pulmonary disease (COPD) and asthma, are currently the third leading cause of death in the United States. We aimed to evaluate changes in prevalence of and risk factors for COPD and asthma among the US adult population. We evaluated changes in prevalence of self-reported doctor-diagnosed COPD (i.e. chronic bronchitis and emphysema) and asthma and self-reported respiratory symptoms comparing data from the 1988-1994 and 2007-2010 National Health and Nutrition Examination Surveys. To investigate changes in the severity of each outcome over the two periods, we calculated changes in the proportions of spirometry-based airflow obstruction for each outcome. Prevalence of doctor-diagnosed chronic bronchitis and emphysema decreased significantly mainly among males, while asthma increased only among females. The self-reported disease and the respiratory symptoms were associated with increased prevalence of airflow obstruction for both periods. However, the prevalence of airflow obstruction decreased significantly in the second period among those with shortness of breath and doctor-diagnosed respiratory conditions (chronic bronchitis, emphysema, and asthma). COPD outcomes and asthma were associated with lower education, smoking, underweight and obesity, and occupational dusts and fumes exposure. Chronic lower airway diseases continue to be major public health problems. However, decreased prevalence of doctor-diagnosed chronic bronchitis and emphysema (in males) and decreased prevalence of airflow obstruction in those with respiratory symptoms and doctor-diagnosed respiratory diseases may indicate a declining trend and decrease in disease severity between the two periods. Continued focus on prevention of these diseases through public health interventions is prudent. C1 [Halldin, Cara N.; Doney, Brent C.; Hnizdo, Eva] NIOSH, Div Resp Dis Studies, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. [Halldin, Cara N.] Ctr Dis Control & Prevent, Epidem Intelligence Serv Program, Atlanta, GA USA. RP Halldin, CN (reprint author), NIOSH, Div Resp Dis Studies, 1095 Willowdale Rd MS HG900-2, Morgantown, WV 26505 USA. EM challdin@cdc.gov FU Centers for Disease Control and Prevention National Institute for Occupational Safety and Health FX This work was performed by US Federal Government employees as part of their work; no non-governmental funding supported this work. The Centers for Disease Control and Prevention National Institute for Occupational Safety and Health supported the salaries of the authors. NR 57 TC 9 Z9 10 U1 0 U2 9 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1479-9723 EI 1479-9731 J9 CHRON RESP DIS JI Chronic Respir. Dis. PD FEB PY 2015 VL 12 IS 1 BP 47 EP 60 DI 10.1177/1479972314562409 PG 14 WC Respiratory System SC Respiratory System GA CA0ZA UT WOS:000348640800007 PM 25540134 ER PT J AU Lanzieri, TM Kruszon-Moran, D Amin, MM Bialek, SR Cannon, MJ Carroll, MD Dollard, SC AF Lanzieri, Tatiana M. Kruszon-Moran, Deanna Amin, Minal M. Bialek, Stephanie R. Cannon, Michael J. Carroll, Margaret D. Dollard, Sheila C. TI Seroprevalence of Cytomegalovirus among Children 1 to 5 Years of Age in the United States from the National Health and Nutrition Examination Survey of 2011 to 2012 SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID INFECTION; PREVALENCE; RISK AB Cytomegalovirus (CMV) seroprevalence among U. S. children 1 to 5 years old was assessed in the National Health and Nutrition Examination Survey of 2011 to 2012. The overall seroprevalence (95% confidence interval) of IgG was 20.7% (14.4 to 28.2%), that of IgM was 1.1% (0.4 to 2.4%), and that of low IgG avidity was 3.6% (1.7 to 6.6%), corresponding to a 17.3% (10.1 to 26.7%) prevalence of recent infection among IgG-positive children. C1 [Lanzieri, Tatiana M.; Amin, Minal M.; Bialek, Stephanie R.; Dollard, Sheila C.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Kruszon-Moran, Deanna; Carroll, Margaret D.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Cannon, Michael J.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. RP Lanzieri, TM (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM tmlanzieri@cdc.gov NR 14 TC 4 Z9 4 U1 1 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 EI 1556-679X J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD FEB PY 2015 VL 22 IS 2 BP 245 EP 247 DI 10.1128/CVI.00697-14 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CA2YN UT WOS:000348772200014 PM 25520150 ER PT J AU Hess, KL Chavez, PR Kanny, D DiNenno, E Lansky, A Paz-Bailey, G AF Hess, Kristen L. Chavez, Pollyanna R. Kanny, Dafna DiNenno, Elizabeth Lansky, Amy Paz-Bailey, Gabriela CA NHBS Study Grp TI Binge drinking and risky sexual behavior among HIV-negative and unknown HIV status men who have sex with men, 20 US cities SO DRUG AND ALCOHOL DEPENDENCE LA English DT Article DE Binge drinking; Men who have sex with men; Anal intercourse; Risky sex behaviors; HIV ID SUBSTANCE USE; ALCOHOL-USE; YOUNG MEN; SURVEILLANCE SYSTEM; LEVEL ANALYSIS; BISEXUAL MEN; UNSAFE SEX; DRUG-USE; INFECTION; ASSOCIATION AB Background: Men who have sex with men (MSM) represent over half of new HIV infections in the United States. It is important to understand the factors associated with engaging in risky sexual behavior to develop effective prevention interventions. Binge drinking (>= 5 drinks on >= 1 occasion) is the most common form of excessive alcohol consumption. This study examines the relationship between binge drinking and sexual risk behaviors among MSM who are current drinkers and who were either HIV-negative or unaware of their HIV status. Methods: Using the 2011 National HIV Behavioral Surveillance system and multivariable Poisson models with robust error estimates, we assessed the association between binge drinking and sexual risk behaviors among current drinkers. Prevalence ratios (PR) and 95% confidence intervals (CI) are presented. Results: Overall, 85% of MSM were current drinkers, and 59% of MSM who drank reported >= 1 episode of binge drinking in the preceding 30 days. In multivariable models, binge drinking was associated with condomless anal intercourse (CAI) at last sex with an HIV-positive or unknown status partner (receptive: PR 1.3,95% CI 1.1-1.6; insertive: PR 1.2,95% CI 1.0-1.4), having exchanged sex for money or drugs at last sex (PR: 1.4, 95% CI 1.1-1.7), having concurrent partners in the past year (PR: 1.1, 95% CI 1.1-1.2), and having more CAI partners in the past year (PR: 1.2, 95% CI 1.0-1.4) compared to non-binge drinkers. Conclusions: Evidence-based strategies for reducing binge drinking could help reduce risky sexual behavior among MSM. Published by Elsevier Ireland Ltd. C1 [Hess, Kristen L.; Chavez, Pollyanna R.; DiNenno, Elizabeth; Lansky, Amy; Paz-Bailey, Gabriela] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA 30329 USA. [Kanny, Dafna] Ctr Dis Control & Prevent, Div Populat Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Excess Alcohol Use Prevent Team, Atlanta, GA 30329 USA. RP Hess, KL (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, 1600 Clifton Rd,MS-E46, Atlanta, GA 30329 USA. EM xgm0@cdc.gov; pchavez@cdc.gov; dkk3@cdc.gov; edinenno@cdc.gov; al10@cdc.gov; gmb5@cdc.gov FU Health Department of the 20 US cities in the study [PS11-001]; Health Department of the Centers for Disease Control and Prevention (CDC) [PS11-001] FX This work was funded by a cooperative agreement between the Health Departments of the 20 US cities in the study and the Centers for Disease Control and Prevention (CDC) (Funding Opportunity Announcement #PS11-001). Data collection was conducted by the funded sites in accordance with a standardized protocol developed by CDC. Analysis of NHBS data and preparation of this manuscript were performed by CDC staff. This research was also supported in part by an appointment to the Research Participation Program at the Centers for Disease Control and Prevention administered by the Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement between the U.S. Department of Energy and CDC. ORISE had no role in the preparation of the manuscript. NR 49 TC 8 Z9 8 U1 1 U2 12 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0376-8716 EI 1879-0046 J9 DRUG ALCOHOL DEPEN JI Drug Alcohol Depend. PD FEB 1 PY 2015 VL 147 BP 46 EP 52 DI 10.1016/j.drugalcdep.2014.12.013 PG 7 WC Substance Abuse; Psychiatry SC Substance Abuse; Psychiatry GA CA4RU UT WOS:000348893000006 PM 25555622 ER PT J AU Priest, JW Moss, DM Arnold, BF Hamlin, K Jones, CC Lammie, PJ AF Priest, J. W. Moss, D. M. Arnold, B. F. Hamlin, K. Jones, C. C. Lammie, P. J. TI Seroepidemiology of Toxoplasma in a coastal region of Haiti: multiplex bead assay detection of immunoglobulin G antibodies that recognize the SAG2A antigen SO EPIDEMIOLOGY AND INFECTION LA English DT Article ID CRYPTOSPORIDIUM-PARVUM ANTIGENS; SURFACE-ANTIGEN; LYMPHATIC FILARIASIS; ENZYME-IMMUNOASSAY; GONDII INFECTION; SERUM SAMPLES; UNITED-STATES; CHILDREN; CATS; TRANSMISSION C1 [Priest, J. W.; Moss, D. M.] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Atlanta, GA USA. [Hamlin, K.; Jones, C. C.; Lammie, P. J.] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA USA. [Jones, C. C.] Atlanta Res & Educ Fdn, Decatur, GA USA. [Arnold, B. F.] Univ Calif Berkeley, Sch Publ Hlth, Div Epidemiol, Berkeley, CA 94720 USA. RP Priest, JW (reprint author), 1600 Clifton Rd,Mail Stop D-66, Atlanta, GA 30329 USA. EM jpriest@cdc.gov NR 51 TC 3 Z9 4 U1 0 U2 2 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 EI 1469-4409 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD FEB PY 2015 VL 143 IS 3 BP 618 EP 630 PG 13 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CA1BC UT WOS:000348646700020 PM 25600668 ER PT J AU Wong, KK Cheng, P Foppa, I Jain, S Fry, AM Finelli, L AF Wong, K. K. Cheng, P. Foppa, I. Jain, S. Fry, A. M. Finelli, L. TI Estimated paediatric mortality associated with influenza virus infections, United States, 2003-2010 SO EPIDEMIOLOGY AND INFECTION LA English DT Article DE Influenza; paediatrics; pandemic ID RESPIRATORY SYNCYTIAL VIRUS; 2009 PANDEMIC INFLUENZA; DEATHS; CHILDREN; HOSPITALIZATIONS; DISEASE; BURDEN; AGE AB Death certificate reports and laboratory confirmed influenza deaths probably underestimate paediatric deaths attributable to influenza. Using US mortality data for persons aged < 18 years who died during 28 September 2003 to 2 October 2010, we estimated influenza- attributable deaths using a generalized linear regression model based on seasonal covariates, influenzacertified deaths (deaths for which influenza was a reported cause of death), and occurrence during the 2009 pandemic period. Of 32 783 paediatric deaths in the death categories examined, 853 (3%) were influenza- certified. The estimated number of influenza- attributable deaths over the study period was 1.8 [95% confidence interval (CI) 1.3-2.8] times higher than the number of influenza- certified deaths. Influenza- attributable deaths were 2.1 (95% CI 1.5-3.4)times higher than influenza- certified deaths during the non- pandemic period and 1.1 (95% CI 1.0-1.8) times higher during the pandemic. Overall, US paediatric deaths attributable to influenza were almost twice the number reported by death certificate codes in the seasons prior to the 2009 pandemic. C1 [Wong, K. K.] Ctr Dis Control & Prevent, Epidem Intelligence Serv Assigned Influenza Div, Atlanta, GA USA. [Cheng, P.; Foppa, I.; Jain, S.; Fry, A. M.; Finelli, L.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. RP Wong, KK (reprint author), 1600 Clifton Rd NE,MS E-03, Atlanta, GA 30329 USA. EM vij4@cdc.gov NR 31 TC 1 Z9 1 U1 1 U2 6 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 EI 1469-4409 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD FEB PY 2015 VL 143 IS 3 BP 640 EP 647 DI 10.1017/S0950268814001198 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CA1BC UT WOS:000348646700022 PM 24831613 ER PT J AU Peterman, TA Su, J Bernstein, KT Weinstock, H AF Peterman, Thomas A. Su, John Bernstein, Kyle T. Weinstock, Hillard TI Syphilis in the United States: on the rise? SO EXPERT REVIEW OF ANTI-INFECTIVE THERAPY LA English DT Article DE congenital syphilis; epidemiology; men who have sex with men; prevention; surveillance; syphilis ID SEXUALLY-TRANSMITTED-DISEASES; SECONDARY SYPHILIS; LOS-ANGELES; REPEAT SYPHILIS; SAN-FRANCISCO; MEN; SEX; HIV; COUNTY; WOMEN AB Syphilis rates and trends vary by population subgroup. Among men who have sex with men (MSM), rates of primary and secondary (P&S) syphilis are high throughout the USA (228.8 per 100,000 in 2013). P&S syphilis among women is much less common (0.9 per 100,000 in 2013) and occurs in isolated outbreaks plus in a few counties with persistent low levels of infection. Congenital syphilis trends closely follow P&S trends among women. These trends have implications for prevention. Routine screening among MSM can prevent tertiary syphilis, but despite interventions, rates of infection continue to rise among MSM and will soon approach those last seen in 1982 (estimate: 340.7 per 100,000). Control of syphilis among women is possible and important because it often leads to congenital syphilis. Outbreaks among heterosexuals can be halted by intensive screening, treatment and partner notification. C1 [Peterman, Thomas A.; Su, John; Bernstein, Kyle T.; Weinstock, Hillard] Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA. RP Peterman, TA (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA. EM tap1@cdc.gov NR 42 TC 6 Z9 6 U1 3 U2 10 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1478-7210 EI 1744-8336 J9 EXPERT REV ANTI-INFE JI Expert Rev. Anti-Infect. Ther. PD FEB PY 2015 VL 13 IS 2 BP 161 EP 168 DI 10.1586/14787210.2015.990384 PG 8 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA CA4GH UT WOS:000348862000004 PM 25487961 ER PT J AU Hurst, SA Appelgren, KE Kourtis, AP AF Hurst, Stacey A. Appelgren, Kristie E. Kourtis, Athena P. TI Prevention of mother-to-child transmission of HIV Type 1: the role of neonatal and infant prophylaxis SO EXPERT REVIEW OF ANTI-INFECTIVE THERAPY LA English DT Review DE breastfeeding; HIV; infant; mother; neonatal; perinatal; prevention; prophylaxis; transmission ID HUMAN-IMMUNODEFICIENCY-VIRUS; SINGLE-DOSE NEVIRAPINE; RANDOMIZED CONTROLLED-TRIAL; PLACEBO-CONTROLLED TRIAL; PERSISTENT MITOCHONDRIAL DYSFUNCTION; BREAST-FEEDING MOTHERS; DAR-ES-SALAAM; ANTIRETROVIRAL THERAPY; UNINFECTED INFANTS; DOUBLE-BLIND AB The prevention of mother-to-child transmission (PMTCT) of HIV is one of the great public health successes of the past 20 years. Much concerted research efforts and dedicated work have led to the achievement of very low rates of PMTCT of HIV in settings that can implement optimal prophylaxis. Though several implementation challenges remain, global elimination of pediatric HIV infection seems now more than ever to be an attainable goal. Often overlooked, the role of prophylaxis of the newborn is nevertheless a very important component of PMTCT. In this paper, we focus on the role of neonatal and infant prophylaxis, discuss mechanisms of protection, and present the clinical trial-generated evidence that led to the current recommendations for preventing infections in breastfed and non-breastfed infants. PMTCT of HIV should not end at birth; a continuum of care extending postpartum and postnatally is required to minimize the risk of new pediatric HIV infections. C1 [Hurst, Stacey A.; Appelgren, Kristie E.; Kourtis, Athena P.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Kourtis, AP (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway,MS F-74, Atlanta, GA 30341 USA. EM akourtis@cdc.gov FU Intramural CDC HHS [CC999999] NR 79 TC 3 Z9 3 U1 0 U2 6 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1478-7210 EI 1744-8336 J9 EXPERT REV ANTI-INFE JI Expert Rev. Anti-Infect. Ther. PD FEB PY 2015 VL 13 IS 2 BP 169 EP 181 DI 10.1586/14787210.2015.999667 PG 13 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA CA4GH UT WOS:000348862000005 PM 25578882 ER PT J AU Hulihan, MM Feuchtbaum, L Jordan, L Kirby, RS Snyder, A Young, W Greene, Y Telfair, J Wang, Y Cramer, W Werner, EM Kenney, K Creary, M Grant, AM AF Hulihan, Mary M. Feuchtbaum, Lisa Jordan, Lanetta Kirby, Russell S. Snyder, Angela Young, William Greene, Yvonne Telfair, Joseph Wang, Ying Cramer, William Werner, Ellen M. Kenney, Kristy Creary, Melissa Grant, Althea M. TI State-based surveillance for selected hemoglobinopathies SO GENETICS IN MEDICINE LA English DT Article DE hemoglobinopathies; newborn screening; sickle cell disease; surveillance; thalassemia ID SICKLE-CELL-DISEASE; UNITED-STATES; VISITS; US AB Purpose: The lack of an ongoing surveillance system for hemoglobinopathies in the United States impedes the ability of public health organizations to identify individuals with these conditions, monitor their health-care utilization and clinical outcomes, and understand the effect these conditions have on the health-care system. This article describes the results of a pilot program that supported the development of the infrastructure and data collection methods for a state-based surveillance system for selected hemoglobinopathies. Methods: The system was designed to identify and gather information on all people living with a hemoglobinopathy diagnosis (sickle cell diseases or thalassemias) in the participating states during 2004-2008. Novel, three-level case definitions were developed, and multiple data sets were used to collect information. Results: In total, 31,144 individualS who had a hemoglobinopathy diagnosis during the study period were identified in California; 39,633 in Florida; 20,815 in Georgia; 12,680 in Michigan; 34,853 in New York, and 8,696 in North Carolina. Conclusion: This approach provides a possible model for the development of state-based hemoglobinopathy surveillance systems. C1 [Hulihan, Mary M.; Kenney, Kristy; Creary, Melissa; Grant, Althea M.] Ctr Dis Control & Prevent, Div Blood Disorders, Atlanta, GA 30329 USA. [Feuchtbaum, Lisa] Calif Dept Publ Hlth, Genet Dis Screening Program, Richmond, CA USA. [Jordan, Lanetta] Univ Miami, Miller Sch Med, Miami, FL 33136 USA. [Kirby, Russell S.] Univ S Florida, Coll Publ Hlth, Tampa, FL USA. [Snyder, Angela] Georgia State Univ, Andrew Young Sch Policy Studies, Georgia Hlth Policy Ctr, Atlanta, GA 30303 USA. [Young, William] Michigan Dept Community Hlth, Lansing, MI USA. [Greene, Yvonne] North Carolina Dept Hlth & Human Serv, Raleigh, NC USA. [Telfair, Joseph] Georgia So Univ, Jiann Ping Hsu Coll Publ Hlth, Statesboro, GA 30460 USA. [Wang, Ying] New York State Dept Hlth, Albany, NY USA. [Cramer, William] Penn Dept Hlth, Harrisburg, PA 17108 USA. [Werner, Ellen M.] NHLBI, NIH, Bethesda, MD 20892 USA. RP Hulihan, MM (reprint author), Ctr Dis Control & Prevent, Div Blood Disorders, Atlanta, GA 30329 USA. EM ibx5@cdc.gov FU US Centers for Disease Control and Prevention; National Heart, Lung and Blood Institute [DD09-909, DD10-1017] FX This work was supported by the US Centers for Disease Control and Prevention and the National Heart, Lung and Blood Institute cooperative agreements DD09-909 and DD10-1017. We gratefully acknowledge the assistance of the following individuals and institutions: California: Susan Paulukonis, William Harris, Fred Lorey, Elliott Vichinsky, Lynne Neumayr, Marsha Treadwell, Shanda Robertson, Gabriel Wong, Ashley Holley, Thomas Coates, Sheree Schrager, and Kelly Russell. Florida: Ofelia Alvarez, Robert Hayden, Hua Li, Anthony Panzera, Jean Paul Tanner, and Lois Taylor. Georgia: Sharon Quary, James Eckman, Peter Lane, Robert Gibson, Jackie George, Mei Zhou, Jane Branscomb, JoAnn Beasley, Janeth Spurlin, Beverly Sinclair, Holly Avey, Eldrida Randall, Rodney Theodore, Christopher Perry, Brendan Noggle, Abdullah Kutlar, the Office of Health Indicators for Planning, the Georgia Department of Public Health, and the Georgia Department of Community Health. Michigan: Karen Andruszewski, Janice Bach, Erika Garcia, Violanda Grigorescu, Mary Kleyn, Robin Stottlemyer, and Wanda Whitten Shurney. New York: Michele Caggana and Gang Liu. North Carolina: Daisy Morris and the North Carolina Sickle Cell Program. NR 10 TC 3 Z9 3 U1 0 U2 4 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1098-3600 EI 1530-0366 J9 GENET MED JI Genet. Med. PD FEB PY 2015 VL 17 IS 2 BP 125 EP 130 DI 10.1038/gim.2014.81 PG 6 WC Genetics & Heredity SC Genetics & Heredity GA CA5QJ UT WOS:000348962600005 PM 24991875 ER PT J AU Collier, MG Tong, X Xu, FJ AF Collier, Melissa G. Tong, Xin Xu, Fujie TI Hepatitis A Hospitalizations in the United States, 2002-2011 SO HEPATOLOGY LA English DT Article ID ACUTE VIRAL-HEPATITIS; VACCINATION COVERAGE; GREEN ONIONS; OUTBREAK; SURVEILLANCE; IMMUNIZATION; CHILDREN; ADULTS; HEALTH AB Hepatitis A illness severity increases with age. One indicator of hepatitis A illness severity is whether persons are hospitalized. We describe changes in primary hepatitis A hospitalization rates in the United States from 2002-2011, including changes in demographics, secondary discharge diagnoses, and factors affecting hospitalization duration. We describe changes from 2002-2011 among U.S. residents hospitalized with a principal hepatitis A diagnosis and accompanying secondary diagnoses using ICD-9 codes from the National Inpatient Survey discharge data. We calculated rates of hospitalizations with hepatitis A as the principal discharge diagnosis and rates of secondary discharge diagnoses. Using multiple regression, we assessed the effect of secondary diagnoses on hospitalization length of stay for five time intervals: 2002-2003, 2004-2005, 2006-2007, 2008-2009, and 2010-2011. Rates of hospitalization for hepatitis A as a principal diagnosis decreased from 0.72/100,000 to 0.29/100,000 (P<0.0001) and mean age of those hospitalized increased from 37.6 years to 45.5 years (P<0.0001) during 2002-2011. The percentage of hepatitis A hospitalizations covered by Medicare increased from 12.4% to 22.7% (P<0.0001). Secondary comorbid discharge diagnoses increased, including liver disease, hypertension, ischemic heart disease, disorders of lipid metabolism, and chronic kidney disease. No changes in length-of-stay or in-hospital deaths from hepatitis A over time were found, but persons with liver disease were hospitalized longer. Conclusion: Hospitalization rates for hepatitis A illness have declined significantly from 2002-2011, but the characteristics of the hospitalized population also changed. Persons hospitalized for hepatitis A in recent years are older and more likely to have liver diseases and other comorbid medical conditions. Hepatitis A disease and resulting hospitalizations could be prevented through adult vaccination. (Hepatology 2015;61:481-485) C1 [Collier, Melissa G.; Tong, Xin; Xu, Fujie] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA USA. RP Collier, MG (reprint author), CDC, Div Viral Hepatitis, Mailstop G-37,1600 Clifton Rd, Atlanta, GA 30333 USA. EM fcv1@cdc.gov NR 16 TC 6 Z9 6 U1 1 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-9139 EI 1527-3350 J9 HEPATOLOGY JI Hepatology PD FEB PY 2015 VL 61 IS 2 BP 481 EP 485 DI 10.1002/hep.27537 PG 5 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AZ9UX UT WOS:000348563200013 PM 25266085 ER PT J AU Henn, SA Boiano, JM Steege, AL AF Henn, Scott A. Boiano, James M. Steege, Andrea L. TI Precautionary Practices of Healthcare Workers Who Disinfect Medical and Dental Devices Using High-Level Disinfectants SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID CONTACT-DERMATITIS; UNITED-STATES; GLUTARALDEHYDE; EXPOSURE; ENDOSCOPY; ASTHMA AB BACKGROUND High-level disinfectants (HLDs) are used throughout the healthcare industry to chemically disinfect reusable, semicritical medical and dental devices to control and prevent healthcare-associated infections among patient populations. Workers who use HLDs are at risk of exposure to these chemicals, some of which are respiratory and skin irritants and sensitizers. OBJECTIVE To evaluate exposure controls used and to better understand impediments to healthcare workers using personal protective equipment while handling HLDs. DESIGN Web-based survey. PARTICIPANTS A targeted sample of members of professional practice organizations representing nurses, technologists/technicians, dental professionals, respiratory therapists, and others who reported handling HLDs in the previous 7 calendar days. Participating organizations invited either all or a random sample of members via email, which included a hyperlink to the survey. METHODS Descriptive analyses were conducted including simple frequencies and prevalences. RESULTS A total of 4,657 respondents completed the survey. The HLDs used most often were glutaraldehyde (59%), peracetic acid (16%), and ortho-phthalaldehyde (15%). Examples of work practices or events that could increase exposure risk included failure to wear water-resistant gowns (44%); absence of standard procedures for minimizing exposure (19%); lack of safe handling training (17%); failure to wear protective gloves (9%); and a spill/leak of HLD during handling (5%). Among all respondents, 12% reported skin contact with HLDs, and 33% of these respondents reported that they did not always wear gloves. CONCLUSION Findings indicated that precautionary practices were not always used, underscoring the importance of improved employer and worker training and education regarding HLD hazards. C1 [Henn, Scott A.; Boiano, James M.; Steege, Andrea L.] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. RP Henn, SA (reprint author), NIOSH, 1090 Tusculum Ave,R-19, Cincinnati, OH 45226 USA. EM shenn@cdc.gov RI Steege, Andrea/H-8900-2016 OI Steege, Andrea/0000-0001-5665-2559 FU Intramural CDC HHS [CC999999] NR 25 TC 2 Z9 2 U1 0 U2 4 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0899-823X EI 1559-6834 J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD FEB PY 2015 VL 36 IS 2 BP 180 EP 185 DI 10.1017/ice.2014.37 PG 6 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CA7OB UT WOS:000349105700008 PM 25633000 ER PT J AU Dolan, SB Libby, TE Lindley, MC Ahmed, F Stevenson, J Strikas, RA AF Dolan, Samantha B. Libby, Tanya E. Lindley, Megan C. Ahmed, Faruque Stevenson, John Strikas, Raymond A. TI Vaccination Policies Among Health Professional Schools: Evidence of Immunity and Allowance of Vaccination Exemptions SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID UNITED-STATES; MEASLES OUTBREAK; INFLUENZA VACCINATION; RANDOMIZED-TRIAL; PERTUSSIS; COVERAGE; RUBELLA; REQUIREMENTS; PREVENTION; PERSONNEL AB OBJECTIVE To characterize health professional schools by their vaccination policies for acceptable forms of evidence of immunity and exemptions permitted. METHODS Data were collected between September 2011 and April 2012 using an Internet-based survey e-mailed to selected types of accredited health professional programs. Schools were identified through accrediting associations for each type of health professional program. Analysis was limited to schools requiring 1 vaccine recommended by the Advisory Committee on Immunization Practices (ACIP): measles, mumps, rubella, hepatitis B, varicella, pertussis, and influenza. Weighted bivariate frequencies were generated using SAS 9.3. RESULTS Of 2,775 schools surveyed, 75% (n=2,077) responded; of responding schools, 93% (1947) required 1 ACIP-recommended vaccination. The proportion of schools accepting 1 non-ACIP-recommended form of evidence of immunity varied by vaccine: 42% for pertussis, 37% for influenza, 30% for rubella, 22% for hepatitis B, 18% for varicella, and 9% for measles and mumps. Among schools with 1 vaccination requirement, medical exemptions were permitted for 1 vaccine by 75% of schools; 54% permitted religious exemptions; 35% permitted personal belief exemptions; 58% permitted any nonmedical exemption. CONCLUSIONS Many schools accept non-ACIP-recommended forms of evidence of immunity which could lead some students to believe they are protected from vaccine preventable diseases when they may be susceptible. Additional efforts are needed to better educate school officials about current ACIP recommendations for acceptable forms of evidence of immunity so school policies can be revised as needed. C1 Immunizat Serv Div ISD, Natl Ctr Immunizat & Resp Dis NCIRD, Centers Dis Control & Prevent CDC, Atlanta, GA USA. Calif Emerging Infect Program, Oakland, CA USA. [Dolan, Samantha B.; Lindley, Megan C.; Ahmed, Faruque; Stevenson, John; Strikas, Raymond A.] Ctr Dis Control & Prevent CDC, Natl Ctr Immunizat & Resp Dis NCIRD, Immunizat Serv Div ISD, Atlanta, GA USA. [Libby, Tanya E.] Calif Emerging Infect Program, Oakland, CA USA. RP Dolan, SB (reprint author), Ctr Dis Control & Prevent, Immunizat Serv Div, 1600 Clifton Rd,MS A 19, Atlanta, GA 30333 USA. EM uzn7@cdc.gov FU Centers for Disease Control and Prevention and the Association of Schools and Programs of Public Health [U36/CCU300430]; Association of Schools and Programs of Public Health FX Financial Support. This publication was supported by Cooperative Agreement No. U36/CCU300430 from the Centers for Disease Control and Prevention and the Association of Schools and Programs of Public Health. S.B.D. received salary support from the Association of Schools and Programs of Public Health. The findings and conclusions of this publication do not necessarily represent the official views of the CDC or the Association of Schools and Programs in Public Health. NR 25 TC 1 Z9 1 U1 1 U2 10 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0899-823X EI 1559-6834 J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD FEB PY 2015 VL 36 IS 2 BP 186 EP 191 DI 10.1017/ice.2014.15 PG 6 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CA7OB UT WOS:000349105700009 PM 25633001 ER PT J AU Rhee, C Huang, SS Berrios-Torres, SI Kaganov, R Bruce, C Lankiewicz, J Platt, R Yokoe, DS AF Rhee, Chanu Huang, Susan S. Berrios-Torres, Sandra I. Kaganov, Rebecca Bruce, Christina Lankiewicz, Julie Platt, Richard Yokoe, Deborah S. CA Ctr Dis Control Prevention CDC TI Surgical Site Infection Surveillance Following Ambulatory Surgery SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID COLORECTAL SURGERY; IMPROVE DETECTION; HYSTERECTOMY AB We assessed 4045 ambulatory surgery patients for surgical site infection (SSI) using claims-based triggers for medical chart review. Of 98 patients flagged by codes suggestive of SSI, 35 had confirmed SSIs. SSI rates ranged from 0 to 3.2% for common procedures. Claims may be useful for SSI surveillance following ambulatory surgery. C1 [Rhee, Chanu; Kaganov, Rebecca; Bruce, Christina; Lankiewicz, Julie; Platt, Richard] Harvard Univ, Dept Populat Med, Sch Med, Boston, MA 02215 USA. [Rhee, Chanu; Kaganov, Rebecca; Bruce, Christina; Lankiewicz, Julie; Platt, Richard] Harvard Pilgrim Hlth Care Inst, Boston, MA 02215 USA. [Rhee, Chanu; Yokoe, Deborah S.] Brigham & Womens Hosp, Div Infect Dis, Boston, MA 02115 USA. [Huang, Susan S.] Univ Calif Irvine, Sch Med, Div Infect Dis, Irvine, CA 92717 USA. [Berrios-Torres, Sandra I.] CDC, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. RP Rhee, C (reprint author), Harvard Univ, Dept Populat Med, Sch Med, 133 Brookline Ave,6th Floor, Boston, MA 02215 USA. EM crhee1@partners.org FU CDC Prevention Epicenters Program [U01CI000344]; National Institutes of Health [T32 AI007061] FX CDC Prevention Epicenters Program (grant U01CI000344 to R.P.); National Institutes of Health (grant T32 AI007061 to C.R.). NR 9 TC 3 Z9 3 U1 0 U2 1 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0899-823X EI 1559-6834 J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD FEB PY 2015 VL 36 IS 2 BP 225 EP 228 DI 10.1017/ice.2014.23 PG 4 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CA7OB UT WOS:000349105700016 PM 25633008 ER PT J AU Saha, S Zhao, YQ Shah, SA Degli Esposti, S Lidofsky, S Bright, R Law, M Moniz, H Samad, Z Merrick, M Sands, BE AF Saha, Sumona Zhao, Ying-Qi Shah, Samir A. Degli Esposti, Silvia Lidofsky, Sheldon Bright, Renee Law, Meaghan Moniz, Heather Samad, Zahid Merrick, Marjorie Sands, Bruce E. TI Body Image Dissatisfaction in Patients with Inflammatory Bowel Disease SO INFLAMMATORY BOWEL DISEASES LA English DT Article DE complications of IBD; clinical areas; gender studies; psychosocial aspects of IBD ID QUALITY-OF-LIFE; MARGINAL STRUCTURAL MODELS; CROHNS-DISEASE; APPEARANCE SCALE; SATISFACTION; VALIDATION; GENDER; WOMEN; HAIR; MEN AB Background:Despite the fact that the inflammatory bowel diseases (IBD) and their treatments may affect physical appearance, the effect of IBD on body image is poorly understood. The aims of this study were to determine whether body image dissatisfaction (BID) changes over time in patients with IBD and to examine the demographic and disease-related variables associated with decreased body image.Methods:Adults aged 18 and above in the Ocean State Crohn's and Colitis Area Registry with at least 2 years of follow-up were eligible for this study. All patients were enrolled within 6 months of IBD diagnosis and followed prospectively. BID was assessed using a modified version of the Adapted Satisfaction With Appearance questionnaire. Total Adapted Satisfaction With Appearance scores and 2 subscores were calculated. To assess for changes over time, general linear models for correlated data were used for continuous outcomes, and generalized estimating equations were used for discrete outcomes.Results:Two hundred seventy-four patients were studied. BID was found to be stable over time among men and women with IBD despite overall improvements in disease activity. No differences were found in BID according to IBD subtype. Female gender, greater disease activity, higher symptom burden, longer duration of steroid use, dermatologic and musculoskeletal manifestations of IBD, and ileocolonic disease location among patients with Crohn's disease were associated with greater BID. Greater BID was associated with lower health-related quality of life.Conclusions:BID remains stable in an incident cohort of IBD despite improved disease activity and is associated with lower health-related quality of life. C1 [Saha, Sumona] Univ Wisconsin, Sch Med & Publ Hlth, Div Gastroenterol & Hepatol, Madison, WI 53705 USA. [Zhao, Ying-Qi] Univ Wisconsin, Sch Med & Publ Hlth, Dept Biostat & Med Informat, Madison, WI 53705 USA. [Shah, Samir A.; Degli Esposti, Silvia; Lidofsky, Sheldon] Brown Univ, Warren Alpert Sch Med, Div Gastroenterol, Providence, RI 02912 USA. [Bright, Renee; Law, Meaghan; Moniz, Heather] Rhode Isl Hosp, Dept Pediat Gastroenterol, Providence, RI USA. [Samad, Zahid] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Merrick, Marjorie] Crohns & Colitis Fdn Amer, New York, NY USA. [Sands, Bruce E.] Icahn Sch Med Mt Sinai, Dr Henry Janowitz Div Gastroenterol, New York, NY 10029 USA. RP Saha, S (reprint author), Univ Wisconsin, Sch Med & Publ Hlth, Div Gastroenterol & Hepatol, UW Med Fdn Centennial Bldg,1685 Highland Ave,Room, Madison, WI 53705 USA. EM ssaha@medicine.wisc.edu OI leleiko, neal/0000-0001-7699-1400 FU CCFA through Centers for Disease Control and Prevention [1 UO1 DP000340-03, 1 U01 DP004785-01]; National Institutes of Health [1R21DK078555-01]; National Institute of Child Health and Human Development (NICHD) [K12HD055894]; Pfizer; Millennium Pharmaceuticals/Takeda; Bristol-Myers Squibb; Abbott Immunology; AbbVie; Imedex; Amgen; Prometheus Laboratories; Centocor/Janssen Biotech; Elan Pharmaceuticals; Strategic Consultants, Inc.; Avaxia Biologics; Immune Pharmaceuticals Corporation; Puretech Ventures; LLC; Sigmoid Biotechnologies; Teva Pharmaceuticals; Baxter Healthcare; Creative Educational Concepts; Curatio CME/Huntsworth Health North America; Focus Medical Communications; AstraZeneca; Luitpold Pharmaceuticals; Salix Pharmaceuticals; Vedanta Biosciences; Dainippon Sumitomo Pharma; Shire; Topivert Pharma; Forest Research Institute FX S. Saha is supported by grants from the CCFA through the Centers for Disease Control and Prevention (1 UO1 DP000340-03 and 1 U01 DP004785-01) and the National Institutes of Health (1R21DK078555-01). S. Saha was supported by Award Number K12HD055894 from the National Institute of Child Health and Human Development (NICHD). B. Sands receives or has received financial compensation as a consultant and lecturer to Pfizer, Millennium Pharmaceuticals/Takeda, Bristol-Myers Squibb, Abbott Immunology, AbbVie, Imedex, Amgen, Prometheus Laboratories, Centocor/Janssen Biotech, Elan Pharmaceuticals, Strategic Consultants, Inc., Avaxia Biologics (of which he owns stock options), Immune Pharmaceuticals Corporation, Puretech Ventures, LLC, Sigmoid Biotechnologies, Teva Pharmaceuticals, Baxter Healthcare, Creative Educational Concepts, Curatio CME/Huntsworth Health North America, Focus Medical Communications, Imedex, AstraZeneca, Luitpold Pharmaceuticals, Salix Pharmaceuticals, Vedanta Biosciences, Dainippon Sumitomo Pharma, Shire, Topivert Pharma, Bristol-Myers Squibb, Forest Research Institute. Samir A. Shah has served as a speaker for AbbVie, Janssen, and Santarus. N. LeLeiko, S. Lidofsky, S. Degli Esposti, R. Bright, Z. Samad, M. Law, H. Moniz, and M. Merrick have no personal interests to declare. NR 33 TC 3 Z9 4 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1078-0998 EI 1536-4844 J9 INFLAMM BOWEL DIS JI Inflamm. Bowel Dis. PD FEB PY 2015 VL 21 IS 2 BP 345 EP 352 DI 10.1097/MIB.0000000000000270 PG 8 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA CA4WA UT WOS:000348906200013 PM 25569736 ER PT J AU Welcome, DE Dong, RG Xu, XYS Warren, C McDowell, TW Wu, JZ AF Welcome, Daniel E. Dong, Ren G. Xu, Xueyan S. Warren, Christopher McDowell, Thomas W. Wu, John Z. TI An examination of the vibration transmissibility of the hand-arm system in three orthogonal directions SO INTERNATIONAL JOURNAL OF INDUSTRIAL ERGONOMICS LA English DT Article DE Hand-arm vibration transmissibility; Hand-transmitted vibration; Human-arm vibration; Vibration biodynamic response ID TRANSMITTED VIBRATION; NONCONTACT MEASUREMENT; BIODYNAMIC RESPONSES; FINGERS; PALM; OPERATORS; GRINDER; FORCES; GLOVES AB The objective of this study is to enhance the understanding of the vibration transmission in the hand-arm system in three orthogonal directions (X, Y, and Z). For the first time, the transmitted vibrations distributed on the entire hand-arm system exposed in the three orthogonal directions via a 3-D vibration test system were measured using a 3-D laser vibrometer. Seven adult male subjects participated in the experiment. This study confirms that the vibration transmissibility generally decreased with the increase in distance from the hand and it varied with the vibration direction. Specifically, to the upper arm and shoulder, only moderate vibration transmission was measured in the test frequency range (16 to 500 Hz), and virtually no transmission was measured in the frequency range higher than 50 Hz. The resonance vibration on the forearm was primarily in the range of 16-30 Hz with the peak amplitude of approximately 1.5 times of the input vibration amplitude. The major resonance on the dorsal surfaces of the hand and wrist occurred at around 30-40 Hz and, in the Y direction, with peak amplitude of more than 2.5 times of the input amplitude. At higher than 50 Hz, vibration transmission was effectively limited to the hand and fingers. A major finger resonance was observed at around 100 Hz in the X and Y directions and around 200 Hz in the Z direction. In the fingers, the resonance magnitude in the Z direction was generally the lowest, and the resonance magnitude in the Y direction was generally the highest with the resonance amplitude of 3 times the input vibration, which was similar to the transmissibility at the wrist and hand dorsum. The implications of the results are discussed. Relevance to industry: Prolonged, intensive exposure to hand-transmitted vibration could result in hand-arm vibration syndrome. While the syndrome's precise mechanisms remain unclear, the characterization of the vibration transmissibility of the system in the three orthogonal dimensions performed in this study can help understand the syndrome and help develop improved frequency weightings for assessing the risk of the exposure for developing various components of the syndrome. Published by Elsevier B.V. C1 [Welcome, Daniel E.; Dong, Ren G.; Xu, Xueyan S.; Warren, Christopher; McDowell, Thomas W.; Wu, John Z.] NIOSH, Engn & Control Technol Branch, Morgantown, WV 26505 USA. RP Dong, RG (reprint author), NIOSH, ECTB, HELD, CDC, 1095 Willowdale Rd,MS L-2027, Morgantown, WV 26505 USA. EM rkd6@cdc.gov OI McDowell, Thomas/0000-0002-2416-2210 FU Intramural CDC HHS [CC999999] NR 43 TC 1 Z9 1 U1 0 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-8141 EI 1872-8219 J9 INT J IND ERGONOM JI Int. J. Ind. Ergon. PD FEB PY 2015 VL 45 BP 21 EP 34 DI 10.1016/j.ergon.2014.11.001 PG 14 WC Engineering, Industrial; Ergonomics SC Engineering GA CA4OF UT WOS:000348883500003 PM 26635424 ER PT J AU Loveday, M Wallengren, K Brust, J Roberts, J Voce, A Margot, B Ngozo, J Master, I Cassell, G Padayatchi, N AF Loveday, M. Wallengren, K. Brust, J. Roberts, J. Voce, A. Margot, B. Ngozo, J. Master, I. Cassell, G. Padayatchi, N. TI Community-based care vs. centralised hospitalisation for MDR-TB patients, KwaZulu-Natal, South Africa SO INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE LA English DT Article DE models of care; HIV; outcomes ID MULTIDRUG-RESISTANT TUBERCULOSIS; HEALTH SYSTEMS; FOLLOW-UP; HIV; METAANALYSIS; INITIATION; MORTALITY; SETTINGS; PROGRAMS; THERAPY AB SETTING: KwaZulu-Natal, South Africa, a predominantly rural province with a high burden of tuberculosis (TB), multidrug-resistant TB (MDR-TB) and human immunodeficiency virus (HIV) infection. OBJECTIVE: To determine the most effective care model by comparing MDR-TB treatment outcomes at community-based sites with traditional care at a central, specialised hospital. DESIGN: A non-randomised observational prospective cohort study comparing community-based and centralised care. Patients at community-based sites were closer to home and had easier access to care, and home-based care was available from treatment initiation. RESULTS: Four community-based sites treated 736 patients, while 813 were treated at the centralised hospital (total = 1549 patients). Overall, 75% were HIV co-infected (community: 76% vs. hospitalised: 73%, P = 0.45) and 86% received antiretroviral therapy (community: 91% vs. hospitalised: 82%, P = 0.22). On multivariate analysis, MDR-TB patients were more likely to have a successful treatment outcome if they were treated at a community-based site (adjusted OR 1.43, P = 0.01). However, outcomes at the four community-based sites were heterogeneous, with Site 1 demonstrating that home-based care was associated with an increased treatment success of 72% compared with success rates of 52-60% at the other three sites. CONCLUSION: Community-based care for MDR-TB patients was more effective than care in a central, specialised hospital. Home-based care further increased treatment success. C1 [Loveday, M.] South African Med Res Council, Hlth Syst Res Unit, Cape Town, South Africa. [Wallengren, K.] TB & HIV Invest Network Think, Durban, South Africa. [Brust, J.] Montefiore Med Ctr, Dept Med, New York, NY USA. [Brust, J.] Albert Einstein Coll Med, New York, NY USA. [Roberts, J.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Voce, A.] Univ KwaZulu Natal, Discipline Publ Hlth Med, Durban, South Africa. [Margot, B.; Ngozo, J.] KwaZulu Natal Dept Hlth, Pietermaritzburg, South Africa. [Master, I.] King Dinuzulu Hosp, Durban, South Africa. [Cassell, G.] Harvard Univ, Sch Med, Boston, MA USA. [Padayatchi, N.] Ctr AIDS Programme Res South Africa, Durban, South Africa. RP Loveday, M (reprint author), South African Med Res Council, Hlth Syst Res Unit, Cape Town, South Africa. EM marian.loveday@mrc.ac.za FU Medical Research Council of South Africa (Cape Town, South Africa); Izumi Foundation (Boston, MA, USA); Lilly Foundation; Columbia University-Southern African Fogarty AITRP, Implementation Science Traineeship Program - United States PEPFAR through the Fogarty International Center, National Institutes of Health [D43TW00231]; National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA [K23AI083088] FX The work was funded by the Medical Research Council of South Africa (Cape Town, South Africa) Izumi Foundation (Boston, MA, USA) and a United Way Worldwide grant made possible by the Lilly Foundation on behalf of the Lilly MDR-TB Partnership (Indianapolis, IN, USA). ML is supported by the Columbia University-Southern African Fogarty AIDS International Training and Research Program (AITRP), Implementation Science Traineeship Program funded by the United States President's Emergency Plan for AIDS Relief (PEPFAR) through the Fogarty International Center, National Institutes of Health (grant # D43TW00231), Bethesda, MD. JB is supported by the National Institute of Allergy and Infectious Diseases (K23AI083088), Bethesda, MD, USA. The funders had no role in study design, in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication. All researchers were independent of funders and sponsors. NR 28 TC 12 Z9 13 U1 0 U2 2 PU INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) PI PARIS PA 68 BOULEVARD SAINT-MICHEL,, 75006 PARIS, FRANCE SN 1027-3719 EI 1815-7920 J9 INT J TUBERC LUNG D JI Int. J. Tuberc. Lung Dis. PD FEB PY 2015 VL 19 IS 2 BP 163 EP 171 DI 10.5588/ijtld.14.0369 PG 9 WC Infectious Diseases; Respiratory System SC Infectious Diseases; Respiratory System GA CA1UM UT WOS:000348696900009 PM 25574914 ER PT J AU Henneberger, PK Liang, X Lillienberg, L Dahlman-Hoglund, A Toren, K Andersson, E AF Henneberger, P. K. Liang, X. Lillienberg, L. Dahlman-Hoglund, A. Toren, K. Andersson, E. TI Occupational exposures associated with severe exacerbation of asthma SO INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE LA English DT Article DE work-exacerbated asthma; job-exposure matrix; occupational epidemiology ID WORK-RELATED ASTHMA; BAR WORKERS; SMOKING BAN; OUTCOMES; HEALTH; POPULATION; PREVALENCE; STATEMENT; WORKPLACE; SYMPTOMS AB BACKGROUND: The exacerbation of asthma by work-place conditions is common, but little is known about which agents pose a risk. OBJECTIVE: We used data from an existing survey of adults with asthma to identify occupational exposures associated with severe exacerbation of asthma. DESIGN: Questionnaires were completed by 557 working adults with asthma. Severe exacerbation of asthma in the past 12 months was defined as asthma-related hospitalization, or reports of both unplanned asthma care and treatment with a short course of oral corticosteroids. Occupational exposures for the same time period were assessed using an asthma-specific job exposure matrix. We modeled severe exacerbation to yield prevalence ratios (PRs) for exposures while controlling for potential confounders. RESULTS: A total of 164 participants (29%) were positive for severe exacerbation, and 227 (40.8%) were assessed as being exposed to asthma agents at work. Elevated PRs were observed for several specific agents, notably the irritant subcategories of environmental tobacco smoke (PR 1.84, 95%CI 1.34-2.51) among all participants, inorganic dusts (PR 2.53, 95%CI 1.37 4.67) among men, and the low molecular weight subcategory of other highly reactive agents (PR 1.97, 95%CI 1.08-3.60) among women. CONCLUSION: Among working adults with asthma, severe exacerbation was associated with several occupational agents. C1 [Henneberger, P. K.; Liang, X.] NIOSH, Div Resp Dis Studies, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. [Lillienberg, L.; Dahlman-Hoglund, A.; Toren, K.; Andersson, E.] Sahlgrens Univ Hosp, Dept Occupat & Environm Med, Gothenburg, Sweden. RP Henneberger, PK (reprint author), NIOSH, Div Resp Dis Studies, Ctr Dis Control & Prevent, 1095 Willowdale Rd,MS H2800, Morgantown, WV 26505 USA. EM pkh0@cdc.gov FU Intramural CDC HHS [CC999999] NR 33 TC 5 Z9 5 U1 3 U2 8 PU INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) PI PARIS PA 68 BOULEVARD SAINT-MICHEL,, 75006 PARIS, FRANCE SN 1027-3719 EI 1815-7920 J9 INT J TUBERC LUNG D JI Int. J. Tuberc. Lung Dis. PD FEB PY 2015 VL 19 IS 2 BP 244 EP 250 DI 10.5588/ijtld.14.0132 PG 7 WC Infectious Diseases; Respiratory System SC Infectious Diseases; Respiratory System GA CA1UM UT WOS:000348696900021 PM 25574926 ER PT J AU Mugwanya, KK Wyatt, C Celum, C Donnell, D Mugo, NR Tappero, J Kiarie, J Ronald, A Baeten, JM AF Mugwanya, Kenneth K. Wyatt, Christina Celum, Connie Donnell, Deborah Mugo, Nelly R. Tappero, Jordan Kiarie, James Ronald, Allan Baeten, Jared M. CA Partners PrEP Study Team TI Changes in Glomerular Kidney Function Among HIV-1-Uninfected Men and Women Receiving Emtricitabine-Tenofovir Disoproxil Fumarate Preexposure Prophylaxis A Randomized Clinical Trial SO JAMA INTERNAL MEDICINE LA English DT Article ID MARGINAL STRUCTURAL MODELS; HIV-INFECTED PATIENTS; ACUTE-RENAL-FAILURE; FILTRATION-RATE; ANTIRETROVIRAL PROPHYLAXIS; POSITIVE PATIENTS; COX REGRESSION; EXPOSURE; DISEASE; METAANALYSIS AB IMPORTANCE Tenofovir disoproxil fumarate (TDF) use has been associated with declines in the estimated glomerular filtration rate (eGFR) when used as part of antiretroviral treatment by persons with human immunodeficiency virus (HIV) type 1, but limited data are available for risk when used as preexposure prophylaxis (PrEP) for HIV-1 prevention. OBJECTIVE To determine whether TDF-based PrEP causes eGFR decline in HIV-1-uninfected adults. DESIGN, SETTING, AND PARTICIPANTS A per-protocol safety analysis of changes in eGFR in the Partners PrEP Study, a randomized, placebo-controlled trial of daily oral TDF and emtricitabine (FTC)-TDF PrEP among heterosexual HIV-1-uninfected members of serodiscordant couples in Kenya and Uganda. The trial was conducted from 2008 to 2012. MAIN OUTCOMES AND MEASURES Predefined outcomes of this analysis were mean eGFR change and a 25% or greater eGFR decline from baseline. The eGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration equation. RESULTS Of 4640 participants in the once-daily TDF (n = 1548), FTC-TDF (n = 1545), or placebo (n = 1547) groups, 63% were men. At enrollment, median age was 35 years (range, 18-64 years), and mean eGFR was 130 mL/min/1.73m(2). During a median follow-up of 18 months (interquartile range 12-27 months), mean within-group eGFR change from baseline was +0.14 mL/min/1.73m(2) for TDF, -0.22 mL/min/1.73m(2) for FTC-TDF, and + 1.37 mL/min/1.73 m(2) for placebo, translating into average declines in eGFR attributable to PrEP vs placebo of -1.23 mL/min/1.73m(2) (95% CI, -2.06 to -0.40; P =.004) for TDF and -1.59 mL/min/1.73m(2) (95% CI, -2.44 to -0.74; P <.001) for FTC-TDF. The difference in mean eGFR between PrEP and placebo appeared by 1 month after randomization, was stable through 12 months, and then appeared to wane thereafter. The respective proportions of persons who developed a confirmed 25% or greater eGFR decline from baseline by 12 and 24 months was 1.3% and 1.8% for TDF and 1.2% and 2.5% for FTC-TDF, and these frequencies were not statistically different from the confirmed decline in the placebo group (0.9% and 1.3% by 12 and 24 months, respectively). CONCLUSIONS AND RELEVANCE In this large randomized, placebo-controlled trial among heterosexual persons, with median follow-up of 18 months and maximum follow-up of 36 months, daily oral TDF-based PrEP resulted in a small but nonprogressive decline in eGFR that was not accompanied by a substantial increase in the risk of clinically relevant (>= 25%) eGFR decline. C1 [Mugwanya, Kenneth K.; Celum, Connie; Baeten, Jared M.] Univ Washington, Dept Epidemiol, Seattle, WA 98104 USA. [Mugwanya, Kenneth K.] Makerere Univ, Sch Publ Hlth, Div Dis Control, Kampala, Uganda. [Wyatt, Christina] Mt Sinai Sch Med, Dept Med, Div Nephrol, New York, NY USA. [Celum, Connie; Donnell, Deborah; Mugo, Nelly R.; Kiarie, James; Baeten, Jared M.] Univ Washington, Dept Global Hlth, Seattle, WA 98104 USA. [Celum, Connie; Baeten, Jared M.] Univ Washington, Dept Med, Seattle, WA 98104 USA. [Donnell, Deborah] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA. [Mugo, Nelly R.] Kenya Govt Med Res Ctr, Nairobi, Kenya. [Tappero, Jordan] Ctr Dis Control & Prevent, Ctr Global Hlth, Div Global Hlth Protect, Atlanta, GA USA. [Kiarie, James] Univ Nairobi, Dept Obstet & Gynecol, Nairobi, Kenya. [Ronald, Allan] Univ Manitoba, Dept Med, Winnipeg, MB, Canada. RP Baeten, JM (reprint author), Univ Washington, Dept Global Hlth, 325 Ninth Ave,UW Box 359927, Seattle, WA 98104 USA. EM jbaeten@uw.edu RI Hendrix, Craig/G-4182-2014; OI Hendrix, Craig/0000-0002-5696-8665; Ronald, Allan/0000-0002-5746-3490; Donnell, Deborah/0000-0002-0587-7480 FU Bill and Melinda Gates Foundation [OPP47674]; US National Institutes of Health [R01MH095507, R01DK100272] FX This work was supported by grant OPP47674 from the Bill and Melinda Gates Foundation and grants R01MH095507 and R01DK100272 from the US National Institutes of Health; study medication was donated by Gilead Sciences. NR 40 TC 23 Z9 24 U1 1 U2 4 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD FEB PY 2015 VL 175 IS 2 BP 246 EP 254 DI 10.1001/jamainternmed.2014.6786 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA CA7TL UT WOS:000349120100024 PM 25531343 ER PT J AU Ford, ES Will, JC Mercado, CI Loustalot, F AF Ford, Earl S. Will, Julie C. Mercado, Carla I. Loustalot, Fleetwood TI Trends in Predicted Risk for Atherosclerotic Cardiovascular Disease Using the Pooled Cohort Risk Equations Among US Adults From 1999 to 2012 SO JAMA INTERNAL MEDICINE LA English DT Letter C1 [Ford, Earl S.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Populat Hlth, Atlanta, GA 30341 USA. [Will, Julie C.; Mercado, Carla I.; Loustalot, Fleetwood] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Heart Dis & Stroke Prevent, Atlanta, GA 30341 USA. RP Ford, ES (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy,MS F78, Atlanta, GA 30341 USA. EM eford@cdc.gov FU Intramural CDC HHS [CC999999] NR 3 TC 2 Z9 2 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD FEB PY 2015 VL 175 IS 2 BP 299 EP 302 DI 10.1001/jamainternmed.2014.6403 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA CA7TL UT WOS:000349120100037 PM 25485596 ER PT J AU Guy, GP Watson, M Haileyesus, T Annest, JL AF Guy, Gery P., Jr. Watson, Meg Haileyesus, Tadesse Annest, Joseph L. TI Indoor Tanning-Related Injuries Treated in a National Sample of US Hospital Emergency Departments SO JAMA INTERNAL MEDICINE LA English DT Letter C1 [Guy, Gery P., Jr.; Watson, Meg] Centers Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Canc Prevent & Control, Atlanta, GA 30341 USA. [Haileyesus, Tadesse; Annest, Joseph L.] Centers Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Div Anal Res & Practice Integrat, Atlanta, GA 30341 USA. RP Guy, GP (reprint author), Centers Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Canc Prevent & Control, 4770 Buford Hwy,MS-F76, Atlanta, GA 30341 USA. EM irm2@cdc.gov FU Intramural CDC HHS [CC999999] NR 5 TC 5 Z9 5 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD FEB PY 2015 VL 175 IS 2 BP 309 EP 311 DI 10.1001/jamainternmed.2014.6697 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA CA7TL UT WOS:000349120100042 PM 25506731 ER PT J AU Wang, LY Michael, SL AF Wang, Li Yan Michael, Shannon L. TI Long-Term Health and Medical Cost Impact of Smoking Prevention in Adolescence SO JOURNAL OF ADOLESCENT HEALTH LA English DT Article DE Smoking in adolescence; Smoking progression probabilities; Daily smoking in adulthood; Medical costs saved; QALYs gained AB Purpose: To estimate smoking progression probabilities from adolescence to young adulthood and to estimate long-term health and medical cost impacts of preventing smoking in today's adolescents. Methods: Using data from the National Longitudinal Study of Adolescent Health (Add Health), we first estimated smoking progression probabilities from adolescence to young adulthood. Then, using the predicted probabilities, we estimated the number of adolescents who were prevented from becoming adult daily smokers as a result of a hypothetical 1 percentage point reduction in the prevalence of ever smoking in today's adolescents. We further estimated lifetime medical costs saved and quality-adjusted life years (QALYs) gained as a result of preventing adolescents from becoming adult daily smokers. All costs were in 2010 dollars. Results: Compared with never smokers, those who had tried smoking at baseline had higher probabilities of becoming current or former daily smokers at follow-up regardless of baseline grade or sex. A hypothetical 1 percentage point reduction in the prevalence of ever smoking in 24.5 million students in 7th-12th grades today could prevent 35,962 individuals from becoming a former daily smoker and 44,318 individuals from becoming a current daily smoker at ages 24-32 years. As a result, lifetime medical care costs are estimated to decrease by $ 1.2 billion and lifetime QALYs is estimated to increase by 98,590. Conclusions: Effective smoking prevention programs for adolescents go beyond reducing smoking prevalence in adolescence; they also reduce daily smokers in young adulthood, increase QALYs, and reduce medical costs substantially in later life. This finding indicates the importance of continued investment in effective youth smoking prevention programs. Published by Elsevier Inc. on behalf of Society for Adolescent Health and Medicine. C1 [Wang, Li Yan] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div Adolescent, Atlanta, GA 30329 USA. [Wang, Li Yan] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Sch Hlth, Atlanta, GA 30329 USA. [Michael, Shannon L.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Populat Hlth, Atlanta, GA 30329 USA. RP Wang, LY (reprint author), Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div Adolescent, 1600 Clifton Rd,MS E-75, Atlanta, GA 30329 USA. EM lgw0@cdc.gov NR 20 TC 3 Z9 3 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X EI 1879-1972 J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD FEB PY 2015 VL 56 IS 2 BP 160 EP 166 DI 10.1016/j.jadohealth.2014.08.025 PG 7 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA AZ8YQ UT WOS:000348498100006 PM 25448613 ER PT J AU Vinje, J AF Vinje, Jan TI Advances in Laboratory Methods for Detection and Typing of Norovirus SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Review ID REVERSE TRANSCRIPTION-PCR; NORWALK-LIKE VIRUSES; UNITED-STATES; COMPLETE GENOME; VIRAL LOAD; GASTROENTERITIS; OUTBREAKS; ASSAY; DISEASE; SURVEILLANCE AB Human noroviruses are the leading cause of epidemic and sporadic gastroenteritis across all age groups. Although the disease is usually self-limiting, in the United States norovirus gastroenteritis causes an estimated 56,000 to 71,000 hospitalizations and 570 to 800 deaths each year. This minireview describes the latest data on laboratory methods (molecular, immunological) for norovirus detection, including real-time reverse transcription-quantitative PCR (RT-qPCR) and commercially available immunological assays as well as the latest FDA-cleared multi-gastrointestinal-pathogen platforms. In addition, an overview is provided on the latest nomenclature and molecular epidemiology of human noroviruses. C1 Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA. RP Vinje, J (reprint author), Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA. EM jvinje@cdc.gov NR 39 TC 94 Z9 97 U1 17 U2 58 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD FEB PY 2015 VL 53 IS 2 BP 373 EP 381 DI 10.1128/JCM.01535-14 PG 9 WC Microbiology SC Microbiology GA AZ9XU UT WOS:000348568500003 PM 24989606 ER PT J AU Chao, DY Galula, JU Shen, WF Davis, BS Chang, GJJ AF Chao, Day-Yu Galula, Jedhan Ucat Shen, Wen-Fan Davis, Brent S. Chang, Gwong-Jen J. TI Nonstructural Protein 1-Specific Immunoglobulin M and G Antibody Capture Enzyme-Linked Immunosorbent Assays in Diagnosis of Flaviviral Infections in Humans SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID JAPANESE ENCEPHALITIS-VIRUS; GLYCOPROTEIN NS1; M IGM; DENGUE; IMMUNIZATION; ANTIGEN; FEVER; ELISA; PROTECTION; ENVELOPE AB IgM antibody-and IgG antibody-capture enzyme-linked immunosorbent assays (MAC/GAC-ELISAs) targeted at envelope protein (E) of dengue viruses (DENV), West Nile virus, and Japanese encephalitis virus (JEV) are widely used as serodiagnostic tests for presumptive confirmation of viral infection. Antibodies directed against the flavivirus nonstructural protein 1 (NS1) have been proposed as serological markers of natural infections among vaccinated populations. The aim of the current study is to optimize an IgM and IgG antibody-capture ELISA (MAC/GAC-ELISA) to detect anti-NS1 antibodies and compare it with anti-E MAC/GAC-ELISA. Plasmids to express premembrane/envelope (prM/E) or NS1 proteins of six medically important flaviviruses, including dengue viruses (DENV-1 to DENV-4), West Nile virus (WNV), and Japanese encephalitis virus (JEV), were constructed. These plasmids were used for the production of prM/E-containing virus-like particles (VLPs) and secreted NS1 (sNS1) from COS-1 cells. Archived clinical specimens from patients with confirmed DENV, JEV, and WNV infections, along with naive sera, were subjected to NS1-MAC/GAC-ELISAs before or after depletion of anti-prM/E antibodies by preabsorption with or without VLPs. Human serum specimens from previously confirmed DENV infections showed significantly enhanced positive-to-negative (P/N) ratios for NS1-MAC/GAC-ELISAs after the depletion of anti-prM/E antibodies. No statistical differences in sensitivities and specificities were found between the newly developed NS1-and VLP-MAC/GAC-ELISAs. Further application of the assays to WNV-and JEV-infected serum panels showed similar results. A novel approach to perform MAC/GAC-ELISAs for NS1 antibody detection was successfully developed with great potential to differentiate antibodies elicited by the tetravalent chimeric yellow fever-17D/dengue vaccine or DENV infection. C1 [Chao, Day-Yu] Natl Chung Hsing Univ, Coll Vet Med, Grad Inst Microbiol & Publ Hlth, Taichung 40227, Taiwan. [Galula, Jedhan Ucat] Natl Chung Hsing Univ, Coll Vet Med, Dept Vet Med, Taichung 40227, Taiwan. [Shen, Wen-Fan] Natl Chung Hsing Univ, PhD Program Microbial Genom, Taichung 40227, Taiwan. [Davis, Brent S.; Chang, Gwong-Jen J.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA. RP Chao, DY (reprint author), Natl Chung Hsing Univ, Coll Vet Med, Grad Inst Microbiol & Publ Hlth, Taichung 40227, Taiwan. EM dychao@nchu.edu.tw; gxc7@cdc.gov FU Ministry of Science and Technology, Taiwan [98-2320-B-005-003-MY3, 101-2321-B-005-018-MY2] FX Travel grants to support D.-Y.C., J.U.G., and W.-F.S. as guest researchers at the Division of Vector-Borne Diseases, CDC, USA, were supported by grants from the Ministry of Science and Technology, Taiwan (grant numbers 98-2320-B-005-003-MY3 and 101-2321-B-005-018-MY2). NR 36 TC 4 Z9 4 U1 1 U2 8 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD FEB PY 2015 VL 53 IS 2 BP 557 EP 566 DI 10.1128/JCM.02735-14 PG 10 WC Microbiology SC Microbiology GA AZ9XU UT WOS:000348568500026 PM 25502522 ER PT J AU Gade, L Grgurich, DE Kerkering, TM Brandt, ME Litvintseva, AP AF Gade, Lalitha Grgurich, Dale E. Kerkering, Thomas M. Brandt, Mary E. Litvintseva, Anastasia P. TI Utility of Real-Time PCR for Detection of Exserohilum rostratum in Body and Tissue Fluids during the Multistate Outbreak of Fungal Meningitis and Other Infections SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID CONTAMINATED METHYLPREDNISOLONE INJECTIONS; BLOOD-SAMPLES; UNITED-STATES; DIAGNOSIS; DNA; ASSAY AB Exserohilum rostratum was the major cause of the multistate outbreak of fungal meningitis linked to contaminated injections of methylprednisolone acetate produced by the New England Compounding Center. Previously, we developed a fungal DNA extraction procedure and broad-range and E. rostratum-specific PCR assays and confirmed the presence of fungal DNA in 28% of the case patients. Here, we report the development and validation of a TaqMan real-time PCR assay for the detection of E. rostratum in body fluids, which we used to confirm infections in 57 additional case patients, bringing the total number of case patients with PCR results positive for E. rostratum to 171 (37% of the 461 case patients with available specimens). Compared to fungal culture and the previous PCR assays, this real-time PCR assay was more sensitive. Of the 139 identical specimens from case patients tested by all three methods, 19 (14%) were positive by culture, 41 (29%) were positive by the conventional PCR assay, and 65 (47%) were positive by the real-time PCR assay. We also compared the utility of the real-time PCR assay with that of the previously described beta-D-glucan (BDG) detection assay for monitoring response to treatment in case patients with serially collected CSF. Only the incident CSF specimens from most of the case patients were positive by real-time PCR, while most of the subsequently collected specimens were negative, confirming our previous observations that the BDG assay was more appropriate than the real-time PCR assay for monitoring the response to treatment. Our results also demonstrate that the real-time PCR assay is extremely susceptible to contamination and its results should be used only in conjunction with clinical and epidemiological data. C1 [Gade, Lalitha; Brandt, Mary E.; Litvintseva, Anastasia P.] Ctr Dis Control & Prevent, Mycot Dis Branch, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Grgurich, Dale E.; Kerkering, Thomas M.] Virginia Tech Caril Sch Med, Div Infect Dis, Roanoke, VA USA. RP Litvintseva, AP (reprint author), Ctr Dis Control & Prevent, Mycot Dis Branch, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. EM frq8@cdc.gov NR 22 TC 4 Z9 4 U1 0 U2 7 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD FEB PY 2015 VL 53 IS 2 BP 618 EP 625 DI 10.1128/JCM.02443-14 PG 8 WC Microbiology SC Microbiology GA AZ9XU UT WOS:000348568500033 PM 25520443 ER PT J AU Guo, YQ Li, N Lysen, C Frace, M Tang, K Sammons, S Roellig, DM Feng, YY Xiao, LH AF Guo, Yaqiong Li, Na Lysen, Colleen Frace, Michael Tang, Kevin Sammons, Scott Roellig, Dawn M. Feng, Yaoyu Xiao, Lihua TI Isolation and Enrichment of Cryptosporidium DNA and Verification of DNA Purity for Whole-Genome Sequencing SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID DISCONTINUOUS SUCROSE; PERCOLL GRADIENTS; CESIUM-CHLORIDE; PARVUM; OOCYSTS; SUBTYPE; HOMINIS; PURIFICATION; SPOROZOITES; ETIOLOGY AB Whole-genome sequencing of Cryptosporidium spp. is hampered by difficulties in obtaining sufficient, highly pure genomic DNA from clinical specimens. In this study, we developed procedures for the isolation and enrichment of Cryptosporidium genomic DNA from fecal specimens and verification of DNA purity for whole-genome sequencing. The isolation and enrichment of genomic DNA were achieved by a combination of three oocyst purification steps and whole-genome amplification (WGA) of DNA from purified oocysts. Quantitative PCR (qPCR) analysis of WGA products was used as an initial quality assessment of amplified genomic DNA. The purity of WGA products was assessed by Sanger sequencing of cloned products. Next-generation sequencing tools were used in final evaluations of genome coverage and of the extent of contamination. Altogether, 24 fecal specimens of Cryptosporidium parvum, C. hominis, C. andersoni, C. ubiquitum, C. tyzzeri, and Cryptosporidium chipmunk genotype I were processed with the procedures. As expected, WGA products with low (<16.0) threshold cycle (CT) values yielded mostly Cryptosporidium sequences in Sanger sequencing. The cloning-sequencing analysis, however, showed significant contamination in 5 WGA products (proportion of positive colonies derived from Cryptosporidium genomic DNA, <25%). Following this strategy, 20 WGA products from six Cryptosporidium species or genotypes with low (mostly < 14.0) CT values were submitted to whole-genome sequencing, generating sequence data covering 94.5% to 99.7% of Cryptosporidium genomes, with mostly minor contamination from bacterial, fungal, and host DNA. These results suggest that the described strategy can be used effectively for the isolation and enrichment of Cryptosporidium DNA from fecal specimens for whole-genome sequencing. C1 [Guo, Yaqiong; Li, Na; Feng, Yaoyu] E China Univ Sci & Technol, Sch Resources & Environm Engn, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China. [Guo, Yaqiong; Lysen, Colleen; Roellig, Dawn M.; Xiao, Lihua] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Foodborne Waterborne & Environm Dis, Atlanta, GA USA. [Frace, Michael; Tang, Kevin; Sammons, Scott] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Sci Resources, Atlanta, GA USA. RP Feng, YY (reprint author), E China Univ Sci & Technol, Sch Resources & Environm Engn, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China. EM yyfeng@ecust.edu.cn; lxiao@cdc.gov RI Feng, Yaoyu/B-3076-2014; Yaqiong, Guo/N-4927-2015; Xiao, Lihua/B-1704-2013 OI Xiao, Lihua/0000-0001-8532-2727 FU National Natural Science Foundation of China [31229005, 31110103901]; Centers for Disease Control and Prevention, USA FX This work was supported by the National Natural Science Foundation of China (31229005 and 31110103901) and Centers for Disease Control and Prevention, USA. NR 19 TC 8 Z9 8 U1 2 U2 11 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD FEB PY 2015 VL 53 IS 2 BP 641 EP 647 DI 10.1128/JCM.02962-14 PG 7 WC Microbiology SC Microbiology GA AZ9XU UT WOS:000348568500036 PM 25520441 ER PT J AU Hendriksen, RS Leekitcharoenphon, P Mikoleit, M Jensen, JD Kaas, RS Roer, L Joshi, HB Pornruangmong, S Pulsrikarn, C Gonzalez-Aviles, GD Reuland, EA Al Naiemi, N Wester, AL Aarestrup, FM Hasman, H AF Hendriksen, Rene S. Leekitcharoenphon, Pimlapas Mikoleit, Matthew Jensen, Jacob Dyring Kaas, Rolf Sommer Roer, Louise Joshi, Heena B. Pornruangmong, Srirat Pulsrikarn, Chaiwat Gonzalez-Aviles, Gladys D. Reuland, E. Ascelijn Al Naiemi, Nashwan Wester, Astrid Louise Aarestrup, Frank M. Hasman, Henrik TI Genomic Dissection of Travel-Associated Extended-Spectrum-Beta-Lactamase-Producing Salmonella enterica Serovar Typhi Isolates Originating from the Philippines: a One-Off Occurrence or a Threat to Effective Treatment of Typhoid Fever? SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID CONJUGATIVE ELEMENTS; VI EXOPOLYSACCHARIDE; ISLAND; GENES AB One unreported case of extended-spectrum-beta-lactamase (ESBL)-producing Salmonella enterica serovar Typhi was identified, whole-genome sequence typed, among other analyses, and compared to other available genomes of S. Typhi. The reported strain was similar to a previously published strain harboring bla(SHV-12) from the Philippines and likely part of an undetected outbreak, the first of ESBL-producing S. Typhi. C1 [Hendriksen, Rene S.; Leekitcharoenphon, Pimlapas; Jensen, Jacob Dyring; Kaas, Rolf Sommer; Roer, Louise; Aarestrup, Frank M.; Hasman, Henrik] Tech Univ Denmark, WHO Collaborating Ctr Antimicrobial Resistance Fo, Natl Food Inst, Reference Lab Antimicrobial Resistance, Kongens Lyngby, Denmark. [Mikoleit, Matthew; Joshi, Heena B.; Gonzalez-Aviles, Gladys D.] Natl Ctr Emerging & Zoonot Infect Dis, Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Enter Dis Lab Branch, Atlanta, GA USA. [Pornruangmong, Srirat; Pulsrikarn, Chaiwat] Minist Publ Hlth, WHO Natl Salmonella & Shigella Ctr, Natl Inst Hlth, Dept Med Sci, Bangkok, Thailand. [Al Naiemi, Nashwan] Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands. [Al Naiemi, Nashwan] Ziekenhuis Grp Twente, Amsterdam, Netherlands. [Wester, Astrid Louise] Norwegian Inst Publ Hlth, Dept Foodborne Infect, Div Infect Dis Control, Oslo, Norway. RP Hendriksen, RS (reprint author), Tech Univ Denmark, WHO Collaborating Ctr Antimicrobial Resistance Fo, Natl Food Inst, Reference Lab Antimicrobial Resistance, Kongens Lyngby, Denmark. EM rshe@food.dtu.dk OI Roer, Louise/0000-0001-6892-913X FU Danish Council for Strategic Research [09-067103]; Center for Genomic Epidemiology; World Health Organization Global Foodborne Infections Network FX This work was supported by the Danish Council for Strategic Research (grant 09-067103), the Center for Genomic Epidemiology (www.genomicepidemiology.org), and the World Health Organization Global Foodborne Infections Network (www.who.int/gfn). NR 18 TC 4 Z9 4 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD FEB PY 2015 VL 53 IS 2 BP 677 EP 680 DI 10.1128/JCM.03104-14 PG 4 WC Microbiology SC Microbiology GA AZ9XU UT WOS:000348568500044 PM 25428145 ER PT J AU de Jong, LIT Fernandez, RA Pareja, V Giaroli, G Guidarelli, SR Dykes, JK Luquez, C AF de Jong, Laura I. T. Fernandez, Rafael A. Pareja, Virtudes Giaroli, Gabriel Guidarelli, Sergio R. Dykes, Janet K. Luquez, Carolina TI First Report of an Infant Botulism Case Due to Clostridium botulinum Type Af SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID GENETIC DIVERSITY; STRAINS; NEUROTOXIN; CLUSTERS; SEQUENCE AB Most infant botulism cases worldwide are due to botulinum toxin types A and B. Rarely, Clostridium botulinum strains that produce two serotypes (Ab, Ba, and Bf) have also been isolated from infant botulism cases. This is the first reported case of infant botulism due to C. botulinum type Af worldwide. C1 [de Jong, Laura I. T.; Fernandez, Rafael A.; Pareja, Virtudes] Univ Nacl Cuyo, Area Microbiol, Fac Ciencias Med, RA-5500 Mendoza, Argentina. [Giaroli, Gabriel; Guidarelli, Sergio R.] Hosp Teodoro J Schestakow, Mendoza, Argentina. [Dykes, Janet K.; Luquez, Carolina] Ctr Dis Control & Prevent, Enter Dis Lab Branch, Atlanta, GA 30333 USA. RP Luquez, C (reprint author), Ctr Dis Control & Prevent, Enter Dis Lab Branch, Atlanta, GA 30333 USA. EM CLuquez@cdc.gov FU Universidad Nacional de Cuyo; Centers for Disease Control and Prevention, Office of Public Health Preparedness and Response FX This work was supported by funds made available from the Universidad Nacional de Cuyo and from the Centers for Disease Control and Prevention, Office of Public Health Preparedness and Response. NR 16 TC 1 Z9 1 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD FEB PY 2015 VL 53 IS 2 BP 740 EP 742 DI 10.1128/JCM.02894-14 PG 3 WC Microbiology SC Microbiology GA AZ9XU UT WOS:000348568500060 PM 25502535 ER PT J AU Guo, M Dubey, JP Hill, D Buchanan, RL Gamble, HR Jones, JL Pradhan, AK AF Guo, Miao Dubey, Jitender P. Hill, Dolores Buchanan, Robert L. Gamble, H. Ray Jones, Jeffrey L. Pradhan, Abani K. TI Prevalence and Risk Factors for Toxoplasma gondii Infection in Meat Animals and Meat Products Destined for Human Consumption SO JOURNAL OF FOOD PROTECTION LA English DT Review ID FREE-RANGE CHICKENS; NEOSPORA-CANINUM ANTIBODIES; SAO-PAULO-STATE; POLYMERASE-CHAIN-REACTION; MODIFIED AGGLUTINATION-TEST; CROSS-SECTIONAL SURVEY; FERNANDO-DE-NORONHA; PIG BREEDING FARMS; UNITED-STATES; DOMESTIC PIGS AB Toxoplasma gondii is a protozoan parasite that is responsible for approximately 24% of all estimated deaths attributed to foodborne pathogens in the United States. Human infection results from accidental ingestion of oocysts from the environment, in water, or on insufficiently washed produce or from consumption of raw or undercooked meat products that contain T. gondii tissue cysts. This review focused on studies of T. gondii in meat because many human T. gondii infections are acquired through consumption of raw or undercooked meat. Prevalence of T. gondii is higher in conventionally reared pigs, sheep, and poultry than in cattle and is greater in meat products from organic than from conventionally reared meat animals because of outdoor access, which poses substantially greater opportunities for exposure to infected rodents, wildlife, and oocyst-contaminated feed, water, or environmental surfaces. Risk factors related to T. gondii exposure for livestock include farm type, feed source, presence of cats, methods of rodent and bird control, methods of carcass handling, and water quality. This review serves as a useful resource and information repository for informing quantitative risk assessment studies for T. gondii infection in humans through meat consumption. C1 [Guo, Miao; Buchanan, Robert L.; Pradhan, Abani K.] Univ Maryland, Dept Nutr & Food Sci, College Pk, MD 20742 USA. [Buchanan, Robert L.; Pradhan, Abani K.] Univ Maryland, Ctr Food Safety & Secur Syst, College Pk, MD 20742 USA. [Dubey, Jitender P.; Hill, Dolores] USDA, ARS, Beltsville Agr Res Ctr, Anim Parasit Dis Lab, Beltsville, MD 20705 USA. [Gamble, H. Ray] Natl Acad Sci, Fellowships Off, Washington, DC 20001 USA. [Jones, Jeffrey L.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Pradhan, AK (reprint author), Univ Maryland, Dept Nutr & Food Sci, College Pk, MD 20742 USA. EM akp@umd.edu FU USDA National Institute of Food and Agriculture (NIFA) Agriculture and Food Research Initiative [2012-67005-19611] FX This work was supported through a grant from the USDA National Institute of Food and Agriculture (NIFA) Agriculture and Food Research Initiative (award 2012-67005-19611). NR 253 TC 15 Z9 17 U1 7 U2 50 PU INT ASSOC FOOD PROTECTION PI DES MOINES PA 6200 AURORA AVE SUITE 200W, DES MOINES, IA 50322-2863 USA SN 0362-028X EI 1944-9097 J9 J FOOD PROTECT JI J. Food Prot. PD FEB PY 2015 VL 78 IS 2 BP 457 EP 476 DI 10.4315/0362-028X.JFP-14-328 PG 20 WC Biotechnology & Applied Microbiology; Food Science & Technology SC Biotechnology & Applied Microbiology; Food Science & Technology GA CA6YW UT WOS:000349064800030 PM 25710166 ER PT J AU Liu, SJ Iqbal, K Shallow, S Speers, S Rizzo, E Gerard, K Poissant, T Klevens, RM AF Liu, Stephen J. Iqbal, Kashif Shallow, Sue Speers, Suzanne Rizzo, Elena Gerard, Kristin Poissant, Tasha Klevens, R. Monina TI Characterization of Chronic Hepatitis B Cases Among Foreign-Born Persons in Six Population-Based Surveillance Sites, United States 2001-2010 SO JOURNAL OF IMMIGRANT AND MINORITY HEALTH LA English DT Article DE Chinese-born; Birth country; HBsAg prevalence; Perinatal transmission; Provider screening ID NEW-YORK-CITY; VIRUS INFECTION; PREVALENCE; EPIDEMIOLOGY AB National surveys indicate prevalence of chronic hepatitis B among foreign-born persons in the USA is 5.6 times higher than US-born. Centers for Disease Control and Prevention funded chronic hepatitis B surveillance in Emerging Infections Program sites. A case was any chronic hepatitis B case reported to participating sites from 2001 to 2010. Sites collected standardized demographic data on all cases. We tested differences between foreign- and US-born cases by age, sex, and pregnancy using Chi square tests. We examined trends by birth country during 2005-2010. Of 36,008 cases, 21,355 (59.3 %) reported birth in a country outside the USA, 2,323 (6.5 %) were US-born. Compared with US-born, foreign-born persons were 9.2 times more frequent among chronic hepatitis B cases. Foreign-born were more frequently female, younger, ever pregnant, and born in China. Percentages of cases among foreign-born persons were constant during 2005-2010. Our findings support information from US surveillance for Hepatitis B screening and vaccination efforts. C1 [Liu, Stephen J.; Iqbal, Kashif; Klevens, R. Monina] Ctr Dis Control & Prevent, Div Viral Hepatitis, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Liu, Stephen J.] Ctr Dis Control & Prevent, Div Viral Hepatitis, Epidemiol & Surveillance Branch, Natl Ctr Infect Dis, Atlanta, GA 30333 USA. [Shallow, Sue] San Francisco Dept Publ Hlth, San Francisco, CA USA. [Speers, Suzanne; Gerard, Kristin] Connecticut Dept Publ Hlth, Hartford, CT USA. [Rizzo, Elena] New York State Dept Hlth, Albany, NY USA. [Poissant, Tasha] Oregon Hlth Author, Portland, OR USA. RP Liu, SJ (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, Epidemiol & Surveillance Branch, Natl Ctr Infect Dis, 1600 Clifton Rd NE,Mail Stop,G-37, Atlanta, GA 30333 USA. EM Sliu1110@gmail.com OI Poissant, Tasha/0000-0003-4407-272X NR 24 TC 2 Z9 2 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1557-1912 EI 1557-1920 J9 J IMMIGR MINOR HEALT JI J. Immigr. Minor. Health PD FEB PY 2015 VL 17 IS 1 BP 7 EP 12 DI 10.1007/s10903-014-0012-0 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ7LO UT WOS:000348400700002 PM 24705737 ER PT J AU Willis, LA Opoku, J Murray, A West, T Johnson, AS Pappas, G Sutton, MY AF Willis, Leigh A. Opoku, Jenevieve Murray, Ashley West, Tiffany Johnson, Anna Satcher Pappas, Gregory Sutton, Madeline Y. TI Diagnoses of Human Immunodeficiency Virus (HIV) Infection Among Foreign-Born Persons Living in the District of Columbia SO JOURNAL OF IMMIGRANT AND MINORITY HEALTH LA English DT Article DE HIV; District of Columbia; Foreign-born; Linkage to care ID UNITED-STATES; BLACK-AFRICAN; CARE; IMMIGRANTS; EPIDEMIC; RISK; PREVENTION AB This study characterizes available surveillance data for HIV infected foreign-born residents in the District of Columbia (DC) to inform local HIV prevention and care efforts. HIV surveillance data were reviewed for adults and adolescents (ages a parts per thousand yen13 years) living with HIV in 2008. Variables analyzed included demographics, region of origin (for persons born outside of the U.S.), insurance coverage, linkage to and continuous HIV care. Of the 16,513 DC residents living with HIV diagnoses, 1,391 (8.4 %) were foreign-born. Of foreign-born infected, 71.9 % were male; 33.3 % were from Africa and 20.8 % from Central America; 80.6 % were exposed through sex; 36.3 % had health coverage at diagnosis. While 100 % of foreign-born persons had documented linkage to HIV care, only 18.0 % had documentation of continued HIV care. These data suggest that strengthening continuous HIV care support after successful care linkage is warranted for foreign-born persons living with HIV in DC. C1 [Willis, Leigh A.; Murray, Ashley; Johnson, Anna Satcher; Sutton, Madeline Y.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Druid Hills, GA USA. [Willis, Leigh A.] DHAP NCHHSTP CDC, Washington, DC USA. [Opoku, Jenevieve; West, Tiffany; Pappas, Gregory] Dist Columbia Dept Hlth, HIV AIDS Hepatitis STD & TB Adm, Washington, DC USA. RP Sutton, MY (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Druid Hills, GA USA. EM lwillis@cdc.gov; msutton@cdc.gov NR 27 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1557-1912 EI 1557-1920 J9 J IMMIGR MINOR HEALT JI J. Immigr. Minor. Health PD FEB PY 2015 VL 17 IS 1 BP 37 EP 46 DI 10.1007/s10903-013-9878-5 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ7LO UT WOS:000348400700006 PM 23897303 ER PT J AU Mizuno, Y Borkowf, CB Ayala, G Carballo-Dieguez, A Millett, GA AF Mizuno, Yuko Borkowf, Craig B. Ayala, George Carballo-Dieguez, Alex Millett, Gregorio A. TI Correlates of Sexual Risk for HIV Among US-Born and Foreign-Born Latino Men Who Have Sex with Men (MSM): An Analysis from the Brothers y Hermanos Study SO JOURNAL OF IMMIGRANT AND MINORITY HEALTH LA English DT Article DE Latino MSM; Nativity; Correlates; Sexual risk behavior ID SUBSTANCE USE; BLACK-MEN; IMMIGRANT GENERATION; INTERCOURSE; PREDICTORS; INFECTION; GAY AB Little research has been conducted to examine whether correlates of sexual risk vary by nativity among Latino men who have sex with men (MSM). We used cross sectional data collected from 870 Latino MSM recruited with respondent-driven sampling techniques. For each sub-sample (US-born and foreign-born), we assessed the association between each of the potential correlates (substance use, acculturation, social support, and social discrimination) and sexual risk behavior. Illicit drug use was associated with increased odds of sexual risk behavior in both US-born (OR = 2.17, 95 % CI 1.17-4.03) and foreign-born (OR = 1.86, 1.14-3.05) subgroups. Multivariate correlates specific to foreign-born men included binge drinking (OR = 1.91, 1.17-3.14), 15 years or longer spent in the US (OR = 1.79, 1.06-3.03) and exposure to social discrimination (OR = 2.02, 1.03-3.99). Given the diversity of Latino MSM, information from research that identifies both common and different HIV risk factors across subgroups of Latino MSM may help better tailor HIV prevention programs. C1 [Mizuno, Yuko; Borkowf, Craig B.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Ayala, George] Global Forum MSM & HIV, Oakland, CA USA. [Carballo-Dieguez, Alex] New York State Psychiat Inst & Hosp, New York, NY 10032 USA. [Carballo-Dieguez, Alex] Columbia Univ, New York, NY USA. [Millett, Gregorio A.] Ctr Dis Control & Prevent, Washington, DC USA. RP Mizuno, Y (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, 1600 Clifton Rd,NE Mail Stop E37, Atlanta, GA 30333 USA. EM ymizuno@cdc.gov FU Intramural CDC HHS [CC999999] NR 35 TC 5 Z9 5 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1557-1912 EI 1557-1920 J9 J IMMIGR MINOR HEALT JI J. Immigr. Minor. Health PD FEB PY 2015 VL 17 IS 1 BP 47 EP 55 DI 10.1007/s10903-013-9894-5 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ7LO UT WOS:000348400700007 PM 23949695 ER PT J AU Mangan, JM Galindo-Gonzalez, S Irani, TA AF Mangan, Joan M. Galindo-Gonzalez, Sebastian Irani, Tracy A. TI Development and Initial Testing of Messages to Encourage Tuberculosis Testing and Treatment Among Bacille Calmette-Guerin (BCG) Vaccinated Persons SO JOURNAL OF IMMIGRANT AND MINORITY HEALTH LA English DT Article DE Tuberculosis; BCG vaccine; Health beliefs; Patient education; Message development ID UNITED-STATES; AT-RISK; PERCEPTIONS; EFFICACY; DELAY; TIME AB Misperceptions surrounding the Bacille Calmette-Guerin (BCG) vaccine can lead some vaccinated individuals to resist being tested and treated for tuberculosis (TB). Educational messages to best explain the risk of TB to BCG-vaccinated, Hispanic persons were systematically developed and tested. First, TB program staff provided messages they considered effective. These were analyzed and validated by TB experts, and then presented in group interviews initially to foreign-born Hispanic persons with a TB diagnosis, and then persons without a prior TB diagnosis. Based on interviewees' feedback, preferred statements were used to develop one long and three short comprehensive messages. One-on-one interviews were conducted with Hispanic persons to assess the saliency of the comprehensive educational messages. Participants preferred messages that were gain or positively-framed and explained that BCG does not confer lifelong protection against TB. Participants confirmed the messages would likely have a positive impact on patient decisions to undergo TB testing and treatment. C1 [Mangan, Joan M.] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA. [Galindo-Gonzalez, Sebastian; Irani, Tracy A.] Univ Florida, Dept Agr Educ & Commun, Gainesville, FL USA. RP Mangan, JM (reprint author), Ctr Dis Control & Prevent, Div TB Eliminat, CORP Bldg 12 Rm 3217-01,MS E10, Atlanta, GA 30333 USA. EM bpy4@cdc.gov NR 35 TC 0 Z9 0 U1 1 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1557-1912 EI 1557-1920 J9 J IMMIGR MINOR HEALT JI J. Immigr. Minor. Health PD FEB PY 2015 VL 17 IS 1 BP 79 EP 88 DI 10.1007/s10903-013-9928-z PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ7LO UT WOS:000348400700011 PM 24141428 ER PT J AU Leung, J Lopez, A Mitchell, T Weinberg, M Lee, D Thieme, M Schmid, DS Bialek, SR AF Leung, Jessica Lopez, Adriana Mitchell, Tarissa Weinberg, Michelle Lee, Deborah Thieme, Martha Schmid, D. Scott Bialek, Stephanie R. TI Seroprevalence of Varicella-Zoster Virus in Five US-Bound Refugee Populations SO JOURNAL OF IMMIGRANT AND MINORITY HEALTH LA English DT Article DE Varicella-zoster virus; Varicella; VZV; Seroprevalence; Refugees ID ANTIBODY AB Little is known about varicella-zoster virus (VZV) susceptibility in US-bound refugee populations, although published data suggest that VZV seroprevalence in these refugee populations may be lower than US populations. We describe VZV seroprevalence in five US-bound refugee groups: (1) Bhutanese in Nepal, (2) Burmese on the Thailand-Burma (Myanmar) border, (3) Burmese in Malaysia, (4) Iraqi in Jordan, and (5) Somali in Kenya. Sera were tested for presence of VZV IgG antibodies among adults aged 18-45 years. Overall VZV seroprevalence was 97 % across all refugee groups. VZV seroprevalence was also high across all age groups, with seroprevalence ranging from 92-100 % for 18-26 year-olds depending on refugee group and 93-100 % for 27-45 year-olds. VZV seroprevalence was unexpectedly high in these five US-bound refugee groups, though may not reflect seroprevalence in other refugee groups. Additional studies are needed to better understand VZV seroprevalence in refugee populations over time and by region. C1 [Leung, Jessica; Lopez, Adriana; Thieme, Martha; Schmid, D. Scott; Bialek, Stephanie R.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Mitchell, Tarissa; Weinberg, Michelle; Lee, Deborah] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. RP Leung, J (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM JLeung@cdc.gov FU Intramural CDC HHS [CC999999] NR 13 TC 1 Z9 1 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1557-1912 EI 1557-1920 J9 J IMMIGR MINOR HEALT JI J. Immigr. Minor. Health PD FEB PY 2015 VL 17 IS 1 BP 310 EP 313 DI 10.1007/s10903-013-9946-x PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ7LO UT WOS:000348400700040 PM 24271111 ER PT J AU Costello, RB Saldanha, L Dwyer, J Andrews, K Bailen, R Bailey, R Betz, J Burt, V Chang, F Emenaker, N Gahche, J Hardy, C Pehrsson, P AF Costello, R. B. Saldanha, L. Dwyer, J. Andrews, K. Bailen, R. Bailey, R. Betz, J. Burt, V Chang, F. Emenaker, N. Gahche, J. Hardy, C. Pehrsson, P. TI NEW NATIONAL INSTITUTES OF HEALTH DIETARY SUPPLEMENT LABEL DATABASE CAN AID SEARCH FOR INGREDIENT INFORMATION SO JOURNAL OF INVESTIGATIVE MEDICINE LA English DT Meeting Abstract CT Southern Regional Meeting of the American-Federation-for-Medical-Research CY FEB 26-28, 2015 CL New Orleans, LA SP Amer Federat Med Res C1 [Costello, R. B.; Saldanha, L.; Dwyer, J.; Bailen, R.; Bailey, R.; Betz, J.; Chang, F.; Emenaker, N.] NIH, Bethesda, MD 20892 USA. [Andrews, K.; Pehrsson, P.] USDA, Beltsville, MD 20705 USA. [Burt, V; Gahche, J.] Ctr Dis Control & Prevent, Hyattsville, MD USA. [Hardy, C.] US FDA, College Pk, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1081-5589 EI 1708-8267 J9 J INVEST MED JI J. Invest. Med. PD FEB PY 2015 VL 63 IS 2 MA 218 BP 386 EP 386 PG 1 WC Medicine, General & Internal; Medicine, Research & Experimental SC General & Internal Medicine; Research & Experimental Medicine GA CA0GM UT WOS:000348595000229 ER PT J AU Nielsen, SJ Aoki, Y Kit, BK Ogden, CL AF Nielsen, Samara Joy Aoki, Yutaka Kit, Brian K. Ogden, Cynthia L. TI More Than Half of US Youth Consume Seafood and Most Have Blood Mercury Concentrations below the EPA Reference Level, 2009-2012 SO JOURNAL OF NUTRITION LA English DT Article DE seafood; fish; shellfish; blood mercury; youth ID SEYCHELLES CHILD-DEVELOPMENT; PRENATAL METHYLMERCURY EXPOSURE; NUTRITION EXAMINATION SURVEY; INUIT PRESCHOOL-CHILDREN; FISH CONSUMPTION; QUANTITATIVE-ANALYSIS; COGNITIVE-DEVELOPMENT; NATIONAL-HEALTH; UNITED-STATES; FATTY-ACIDS AB Background: Consuming seafood has health benefits, but seafood can also contain methylmercury, a neurotoxicant. Exposure to methylmercury affects children at different stages of brain development, including during adolescence. Objective: The objective was to examine seafood consumption and blood mercury concentrations in US youth. Methods: In the 2009-2012 NHANES, a cross-sectional nationally representative sample of the US population, seafood consumption in the past 30 d and blood mercury concentrations on the day of examination were collected from 5656 youth aged 1-19 y. Log-linear regression was used to examine the association between frequency of specific seafood consumption and blood mercury concentration, adjusting for race/Hispanic origin, sex, and age. Results: In 2009-2012, 62.4% +/- 1.4% (percent +/- SE) of youth consumed any seafood in the preceding month; 38.4% +/- 1.4% and 48.5% +/- 1.5% reported consuming shellfish and fish, respectively. In 2009-2012, the geometric mean blood mercury concentration was 0.50 +/- 0.02 mu g/L among seafood consumers and 0.27 +/- 0.01 mu g/L among those who did not consume seafood. Less than 0.5% of youth had blood mercury concentrations >= 5.8 mu g/L. In adjusted log-linear regression analysis, no significant associations were observed between frequency of breaded fish or catfish consumption and blood mercury concentrations, but frequency of consuming certain seafood types had significant positive association with blood mercury concentrations: high-mercury fish (swordfish and shark) [exponentiated beta coefficient (exp beta): 2.40; 95% CI: 1.23, 4.68]; salmon (exp beta: 1.41; 95% CI: 1.26, 1.55); tuna (exp beta: 1.38; 95% CI: 1.29, 1.45); crabs (exp beta: 1.35; 95% CI: 1.17, 1.55); shrimp (exp beta: 1.12; 95% CI: 1.05, 1.20), and all other seafood (exp beta: 1.23; 95% Cl: 1.17, 1.32). Age-stratified log-linear regression analyses produced similar results. Conclusion: Few US youth have blood mercury concentrations >= 5.8 mu g/L, although more than half of US youth consumed seafood in the past month. C1 [Nielsen, Samara Joy; Aoki, Yutaka; Kit, Brian K.; Ogden, Cynthia L.] CDC, Div Hlth & Nutr Examinat Surveys, Natl Ctr Hlth Stat, Hyattsville, MD 20781 USA. [Kit, Brian K.] US PHS, Rockville, MD USA. RP Nielsen, SJ (reprint author), CDC, Div Hlth & Nutr Examinat Surveys, Natl Ctr Hlth Stat, Hyattsville, MD 20781 USA. EM wjf7@cdc.gov OI Nielsen, Samara Joy/0000-0002-5777-6542 NR 36 TC 1 Z9 1 U1 3 U2 14 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-3166 EI 1541-6100 J9 J NUTR JI J. Nutr. PD FEB PY 2015 VL 145 IS 2 BP 322 EP 327 DI 10.3945/jn.114.203786 PG 6 WC Nutrition & Dietetics SC Nutrition & Dietetics GA CA6WT UT WOS:000349057200019 PM 25644354 ER PT J AU Cui, WJ Zack, MM Zahran, HS AF Cui, Wanjun Zack, Matthew M. Zahran, Hatice S. TI Health-Related Quality of Life and Asthma among United States Adolescents SO JOURNAL OF PEDIATRICS LA English DT Article ID PULMONARY-FUNCTION; CHILDREN; SEVERITY; IMPACT; RISK; METAANALYSIS; SYMPTOMS; OUTCOMES; SMOKING; ANXIETY AB Objective To examine the direction and the magnitude of associations between asthma and health-related quality of life (HRQoL) in a population-based sample of US adolescents. Study design We obtained data from the 2001-2010 cross-sectional National Health and Nutrition Examination Survey. We used multinomial logistic regression and negative binomial regression to estimate corresponding percentages, prevalence ratios (PRs), and predicted days of 4 domains of HRQoL by 3 asthma status categories: never having asthma, having asthma without symptoms, and having asthma with symptoms. Results Compared with those who never had asthma, adolescents with asthma with symptoms of dry cough or wheezing reported significantly worse self-rated health (13.58% [95% CI, 10.32%-17.67%] vs 7.54% [ 95% CI, 6.50%-8.72%] for fair or poor health), significantly impaired physical health (PR = 1.34, P = .004; adjusted physically unhealthy days, 2.7 days vs 2 days), and impaired mental health (PR = 1.26, P = .025). Among adolescents having asthma with symptoms, those who currently smoked reported 1 more physically unhealthy day and 2.4 more mentally unhealthy days than those who did not smoke and did not have asthma. Those reporting limited physical functioning reported 2 more physically unhealthy days and 1.5 more mentally unhealthy days than those who did not report limited functioning. Conclusion Adolescents with asthma and symptoms reported worse HRQoL compared with those with asthma not reporting symptoms and those without asthma. Those who smoked or reported limited physical functioning reported worse physical and mental HRQoL. Reducing symptoms, quitting smoking, and improving physical functioning may improve HRQoL among adolescents with asthma. C1 [Cui, Wanjun; Zack, Matthew M.] Ctr Dis Control & Prevent, Div Populat Hlth, Atlanta, GA USA. [Zahran, Hatice S.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Environm Hazards & Hlth Effects, Atlanta, GA USA. RP Cui, WJ (reprint author), Div Populat Hlth, 4770 Buford Highway,NE,MS F-78, Atlanta, GA 30341 USA. EM wtd9@cdc.gov FU appointment to the Research Participation Fellowship Program for the Centers for Disease Control and Prevention (CDC) FX W.C. was supported in part by an appointment to the Research Participation Fellowship Program for the Centers for Disease Control and Prevention (CDC), administered by the Oak Ridge Institute for Science and Education (ORISE) through an agreement between the CDC and ORISE. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. The authors declare no conflicts of interest. NR 37 TC 4 Z9 4 U1 1 U2 6 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD FEB PY 2015 VL 166 IS 2 BP 358 EP 364 DI 10.1016/j.jpeds.2014.10.005 PG 7 WC Pediatrics SC Pediatrics GA AZ8XY UT WOS:000348496200034 PM 25454936 ER PT J AU Sawin, KJ Liu, TB Ward, E Thibadeau, J Schechter, MS Soe, MM Walker, W AF Sawin, Kathleen J. Liu, Tiebin Ward, Elisabeth Thibadeau, Judy Schechter, Michael S. Soe, Minn M. Walker, William CA NSBPR Coordinating Comm TI The National Spina Bifida Patient Registry: Profile of a Large Cohort of Participants from the First 10 Clinics SO JOURNAL OF PEDIATRICS LA English DT Article ID UNITED-STATES; BIRTH PREVALENCE; ADOLESCENTS; DEFECTS AB Objective To use data from the US National Spina Bifida Patient Registry (NSBPR) to describe variations in Contexts of Care, Processes of Care, and Health Outcomes among individuals with spina bifida (SB) receiving care in 10 clinics. Study design Reported here are baseline cross-sectional data representing the first visit of 2172 participants from 10 specialized, multidisciplinary SB clinics participating in the NSBPR. We used descriptive statistics, the Fisher exact test, chi(2) test, and Wilcoxon rank-sum test to examine the data. Results The mean age was 10.1 (SD 8.1) years with slightly more female subjects (52.5%). The majority was white (63.4%) and relied upon public insurance (53.5%). One-third had sacral lesions, 44.8% had mid-low lumbar lesions, and 24.9% had high lumbar and thoracic lesions. The most common surgery was ventricular shunt placement (65.7%). The most common bladder-management technique among those with bladder impairment was intermittent catheterization (69.0%). Almost 14% experienced a pressure ulcer in the last year. Of those ages 5 years or older with bowel or bladder impairments, almost 30% were continent of stool; a similar percentage was continent of urine. Most variables were associated with type of SB diagnosis. Conclusion The NSBPR provides a cross section of a predominantly pediatric population of patients followed in specialized SB programs. There were wide variations in the variables studied and major differences in Context of Care, Processes of Care, and Health Outcomes by type of SB. Such wide variation and the differences by type of SB should be considered in future analyses of outcomes. C1 [Sawin, Kathleen J.] Univ Wisconsin, Milwaukee, WI 53201 USA. [Sawin, Kathleen J.; Thibadeau, Judy] Milwaukee Childrens Hosp Wisconsin, Milwaukee, WI USA. [Liu, Tiebin] Ctr Dis Control & Prevent, Atlanta, GA USA. [Ward, Elisabeth] Carter Consulting Inc, Ctr Dis Control & Prevent, Atlanta, GA USA. [Schechter, Michael S.] Virginia Commonwealth Univ, Childrens Hosp Richmond, Richmond, VA USA. [Soe, Minn M.; Walker, William] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA. RP Sawin, KJ (reprint author), Univ Wisconsin, Milwaukee, WI 53201 USA. FU National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention [1UO1DDD000744.01] FX Funded by the National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention (1UO1DDD000744.01). The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. The authors declare no conflicts of interest. NR 18 TC 7 Z9 7 U1 3 U2 4 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD FEB PY 2015 VL 166 IS 2 BP 444 EP + DI 10.1016/j.jpeds.2014.09.039 PG 8 WC Pediatrics SC Pediatrics GA AZ8XY UT WOS:000348496200048 PM 25444012 ER PT J AU Robbins, CL Keyserling, TC Pitts, SJ Morrow, J Moos, MK Johnston, LF Farr, SL AF Robbins, Cheryl L. Keyserling, Thomas C. Pitts, Stephanie Jilcott Morrow, John Moos, Merry-K Johnston, Larry F. Farr, Sherry L. TI Outcomes of Cardiovascular Disease Risk Factor Screening and Referrals in a Family Planning Clinic SO JOURNAL OF WOMENS HEALTH LA English DT Article ID FACILITATION BEHAVIOR; SMOKING-CESSATION; WOMEN AB Background: Cardiovascular disease (CVD) screening in Title X settings can identify low-income women at risk of future chronic disease. This study examines follow-up related to newly identified CVD risk factors in a Title X setting. Methods: Female patients at a North Carolina Title X clinic were screened for CVD risk factors (n=462) and 167/462 (36.1%) were rescreened one year later. Clinical staff made protocol-driven referrals for women identified with newly diagnosed CVD risk factors. We used paired t-tests and chi square tests to compare screening and rescreening results (two-tailed, p<0.05). Results: Among 11 women in need of referrals for newly diagnosed hypertension or diabetes, 9 out of 11 (81.8%) were referred, and 2 of 11 (18.2%) completed referrals. Among hypertensive women who were rescreened (n=21), systolic blood pressure decreased (139 to 132 mmHg, p=0.001) and diastolic blood pressure decreased (90 to 83 mmHg, p=0.006). Hemoglobin A1c did not improve among rescreened diabetic women (n=5, p=0.640). Among women who reported smoking at enrollment, 129 of 148 (87.2%) received cessation counseling and 8 of 148 (5.4%) accepted tobacco quitline referrals. Among smokers, 53 out of 148 (35.8%) were rescreened and 11 of 53 (20.8%) reported nonsmoking at that time. Among 188 women identified as obese at enrollment, 22 (11.7%) scheduled nutrition appointments, but only one attended. Mean weight increased from 221 to 225 pounds (p 0<.05) among 70 out of 188 (37.2%) obese women who were rescreened. Conclusions: The majority of women in need of referrals for CVD risk factors received them. Few women completed referrals. Future research should examine barriers and facilitators of referral care among low-income women. C1 [Robbins, Cheryl L.; Farr, Sherry L.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Keyserling, Thomas C.] Univ N Carolina, Dept Med, Chapel Hill, NC USA. [Keyserling, Thomas C.; Johnston, Larry F.] Univ N Carolina, Ctr Hlth Promot & Dis Prevent, Chapel Hill, NC USA. [Pitts, Stephanie Jilcott] E Carolina Univ, Dept Publ Hlth, Greenville, NC USA. [Morrow, John] Pitt Cty Hlth Dept, Greenville, NC USA. [Moos, Merry-K] Univ N Carolina, Ctr Maternal & Infant Hlth, Chapel Hill, NC USA. RP Robbins, CL (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway NE,Mailstop F-74, Atlanta, GA 30341 USA. EM ggf9@cdc.gov FU Centers for Disease Control and Prevention [5U48DP001944] FX This work was supported by Cooperative Agreement Number 5U48DP001944 from the Centers for Disease Control and Prevention. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 17 TC 0 Z9 0 U1 1 U2 4 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 EI 1931-843X J9 J WOMENS HEALTH JI J. Womens Health PD FEB 1 PY 2015 VL 24 IS 2 BP 131 EP 137 DI 10.1089/jwh.2014.4938 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA CB0NI UT WOS:000349322700006 PM 25517351 ER PT J AU Nair, H Widdowson, MA AF Nair, Harish Widdowson, Marc-Alain TI Paediatric influenza vaccination: time to better protect high-risk groups? SO LANCET RESPIRATORY MEDICINE LA English DT Editorial Material ID YOUNG-CHILDREN C1 [Nair, Harish] Univ Edinburgh, Ctr Populat Hlth Sci, Edinburgh EH8 9AG, Midlothian, Scotland. [Nair, Harish] Publ Hlth Fdn India, New Delhi, India. [Widdowson, Marc-Alain] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. RP Nair, H (reprint author), Univ Edinburgh, Ctr Populat Hlth Sci, Edinburgh EH8 9AG, Midlothian, Scotland. EM Harish.Nair@ed.ac.uk RI Nair, Harish/E-7431-2010 OI Nair, Harish/0000-0002-9432-9100 NR 11 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 2213-2600 J9 LANCET RESP MED JI Lancet Resp. Med. PD FEB PY 2015 VL 3 IS 2 BP 93 EP 94 DI 10.1016/S2213-2600(14)70285-1 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA CA1SP UT WOS:000348692100005 PM 25481380 ER PT J AU Holt, MK Vivolo-Kantor, AM Polanin, JR Holland, KM DeGue, S Matjasko, JL Wolfe, M Reid, G AF Holt, Melissa K. Vivolo-Kantor, Alana M. Polanin, Joshua R. Holland, Kristin M. DeGue, Sarah Matjasko, Jennifer L. Wolfe, Misty Reid, Gerald TI Bullying and Suicidal Ideation and Behaviors: A Meta-Analysis SO PEDIATRICS LA English DT Article ID MIDDLE-SCHOOL STUDENTS; PSYCHOSOCIAL ADJUSTMENT; PEER VICTIMIZATION; RISK BEHAVIOR; ADOLESCENTS; YOUTH; ASSOCIATION; DEPRESSION; VICTIMS; INVOLVEMENT AB BACKGROUND AND OBJECTIVES: Over the last decade there has been increased attention to the association between bullying involvement (as a victim, perpetrator, or bully-victim) and suicidal ideation/behaviors. We conducted a meta-analysis to estimate the association between bullying involvement and suicidal ideation and behaviors. METHODS: We searched multiple online databases and reviewed reference sections of articles derived from searches to identify cross-sectional studies published through July 2013. Using search terms associated with bullying, suicide, and youth, 47 studies (38.3% from the United States, 61.7% in non-US samples) met inclusion criteria. Seven observers independently coded studies and met in pairs to reach consensus. RESULTS: Six different meta-analyses were conducted by using 3 predictors (bullying victimization, bullying perpetration, and bully/victim status) and 2 outcomes (suicidal ideation and suicidal behaviors). A total of 280 effect sizes were extracted and multilevel, random effects meta-analyses were performed. Results indicated that each of the predictors were associated with risk for suicidal ideation and behavior (range, 2.12 [95% confidence interval (CI), 1.67-2.69] to 4.02 [95% CI, 2.39-6.76]). Significant heterogeneity remained across each analysis. The bullying perpetration and suicidal behavior effect sizes were moderated by the study's country of origin; the bully/victim status and suicidal ideation results were moderated by bullying assessment method. CONCLUSIONS: Findings demonstrated that involvement in bullying in any capacity is associated with suicidal ideation and behavior. Future research should address mental health implications of bullying involvement to prevent suicidal ideation/behavior. C1 [Holt, Melissa K.; Reid, Gerald] Boston Univ, Sch Educ, Boston, MA 02215 USA. [Vivolo-Kantor, Alana M.; Holland, Kristin M.; DeGue, Sarah; Matjasko, Jennifer L.; Wolfe, Misty] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Div Violence Prevent, Atlanta, GA USA. [Polanin, Joshua R.] Vanderbilt Univ, Peabody Res Inst, Nashville, TN 37235 USA. RP Holt, MK (reprint author), Boston Univ, Sch Educ, 2 Silber Way, Boston, MA 02215 USA. EM holtm@bu.edu FU Dr Joshua R. Polanin's Institute of Education Sciences Postdoctoral Fellowship [R305B100016] FX A portion of this work was sponsored by Dr Joshua R. Polanin's Institute of Education Sciences Postdoctoral Fellowship grant (R305B100016). Opinions expressed herein do not necessarily reflect those of the Institute of Education Sciences. NR 75 TC 16 Z9 16 U1 8 U2 39 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD FEB PY 2015 VL 135 IS 2 BP E496 EP E509 DI 10.1542/peds.2014-1864 PG 14 WC Pediatrics SC Pediatrics GA CA1IN UT WOS:000348666300027 PM 25560447 ER PT J AU Klein, NP Lewis, E Fireman, B Hambidge, SJ Naleway, A Nelson, JC Belongia, EA Yih, WK Nordin, JD Hechter, RC Weintraub, E Baxter, R AF Klein, Nicola P. Lewis, Edwin Fireman, Bruce Hambidge, Simon J. Naleway, Allison Nelson, Jennifer C. Belongia, Edward A. Yih, W. Katherine Nordin, James D. Hechter, Rulin C. Weintraub, Eric Baxter, Roger TI Safety of Measles-Containing Vaccines in 1-Year-Old Children SO PEDIATRICS LA English DT Article ID IMMUNIZATION PRACTICES ACIP; ATTENUATED INFLUENZA VACCINE; VARICELLA VACCINE; FEBRILE SEIZURES; ADVERSE EVENTS; ADVISORY-COMMITTEE; POSTMARKETING EVALUATION; COMBINATION MEASLES; CEREBELLAR-ATAXIA; CONJUGATE VACCINE AB BACKGROUND AND OBJECTIVES: All measles- containing vaccines are associated with several types of adverse events, including seizure, fever, and immune thrombocytopenia purpura (ITP). Because the measles-mumps-rubellavaricella (MMRV) vaccine compared with the separate measles-mumps-rubella (MMR) and varicella (MMR + V) vaccine increases a toddler's risk for febrile seizures, we investigated whether MMRV is riskier than MMR + V and whether either vaccine elevates the risk for additional safety outcomes. METHODS: Study children were aged 12 to 23 months in the Vaccine Safety Datalink from 2000 to 2012. Nine study outcomes were investigated: 7 main outcomes (anaphylaxis, ITP, ataxia, arthritis, meningitis/encephalitis, acute disseminated encephalomyelitis, and Kawasaki disease), seizure, and fever. Comparing MMRV with MMR + V, relative risk was estimated by using stratified exact binomial tests. Secondary analyses examined post-MMRV or MMR + V risk versus comparison intervals; risk and comparison intervals were then contrasted for MMRV versus MMR+ V. RESULTS: We evaluated 123 200 MMRV and 584 987 MMR + V doses. Comparing MMRV with MMR + V, risks for the 7 main outcomes were not significantly different. Several outcomes had few or zero postvaccination events. Comparing risk versus comparison intervals, ITP risk was higher after MMRV (odds ratio [OR]: 11.3 [95% confidence interval (CI): 1.9 to 68.2]) and MMR + V (OR: 10 [95% CI: 4.5 to 22.5]) and ataxia risk was lower after both vaccines (MMRV OR: 0.8 [95% CI: 0.5 to 1]; MMR + V OR: 0.8 [95% CI: 0.7 to 0.9]). Compared with MMR + V, MMRV increased risk of seizure and fever 7 to 10 days after vaccination. CONCLUSIONS: This study did not identify any new safety concerns comparing MMRV with MMR + V or after either the MMRV or the MMR + V vaccine. This study provides reassurance that these outcomes are unlikely after either vaccine. C1 [Klein, Nicola P.; Lewis, Edwin; Baxter, Roger] Kaiser Permanente Vaccine Study Ctr, Oakland, CA 94612 USA. [Hambidge, Simon J.] Kaiser Permanente Colorado Inst Hlth Res, Denver & Dept Ambulatory Care Serv, Denver, CO USA. [Fireman, Bruce; Naleway, Allison] Ctr Hlth Res, Kaiser Permanente Northwest, Portland, OR USA. [Nelson, Jennifer C.] Univ Washington, Grp Hlth Cooperat, Seattle, WA 98195 USA. [Belongia, Edward A.] Ctr Clin Epidemiol & Populat Hlth, Marshfield Clin Res Fdn, Marshfield, WI USA. [Yih, W. Katherine] Harvard Pilgrim Hlth Care Inst, Boston, MA USA. [Nordin, James D.] Hlth Partners Res Fdn, Minneapolis, MN USA. [Hechter, Rulin C.] Kaiser Permanente So Calif, Pasadena, CA 91101 USA. [Weintraub, Eric] Ctr Dis Control & Prevent, Immunizat Safety Off, Atlanta, GA USA. RP Klein, NP (reprint author), Kaiser Permanente Vaccine Study Ctr, Oakland, CA 94612 USA. FU Centers for Disease Control and Prevention [200-2002-00732] FX Supported by a subcontract with America's Health Insurance Plans under contract 200-2002-00732 from the Centers for Disease Control and Prevention. NR 44 TC 13 Z9 13 U1 0 U2 33 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD FEB PY 2015 VL 135 IS 2 BP E321 EP E329 DI 10.1542/peds.2014-1822 PG 9 WC Pediatrics SC Pediatrics GA CA1IN UT WOS:000348666300007 PM 25560438 ER PT J AU MacNeil, JR Bennett, N Farley, MM Harrison, LH Lynfield, R Nichols, M Petit, S Reingold, A Schaffner, W Thomas, A Pondo, T Mayer, LW Clark, TA Cohn, AC AF MacNeil, Jessica R. Bennett, Nancy Farley, Monica M. Harrison, Lee H. Lynfield, Ruth Nichols, Megin Petit, Sue Reingold, Arthur Schaffner, William Thomas, Ann Pondo, Tracy Mayer, Leonard W. Clark, Thomas A. Cohn, Amanda C. TI Epidemiology of Infant Meningococcal Disease in the United States, 2006-2012 SO PEDIATRICS LA English DT Article ID NEISSERIA-MENINGITIDIS; BACTERIAL-MENINGITIS; CARRIAGE; CHILDREN; SMOKING; RISK; METAANALYSIS; POPULATION AB BACKGROUND: The incidence of meningococcal disease is currently at historic lows in the United States; however, incidence remains highest among infants aged,1 year. With routine use of Haemophilus influenzae type b and pneumococcal vaccines in infants and children in the United States, Neisseria meningitidis remains an important cause of bacterial meningitis in young children. METHODS: Data were collected from active, population-and laboratory-based surveillance for N meningitidis conducted through Active Bacterial Core surveillance during 2006 through 2012. Expanded data collection forms were completed for infant cases identified in the surveillance area during 2006 through 2010. RESULTS: An estimated 113 cases of culture-confirmed meningococcal disease occurred annually among infants aged,1 year in the United States from 2006 through 2012, for an overall incidence of 2.74 per 100 000 infants. Among these cases, an estimated 6 deaths occurred. Serogroup B was responsible for 64%, serogroup C for 12%, and serogroup Y for 16% of infant cases. Based on the expanded data collection forms, a high proportion of infant cases ( 36/ 58, 62%) had a smoker in the household and the socioeconomic status of the census tracts where infant meningococcal cases resided was lower compared with the other Active Bacterial Core surveillance areas and the United States as a whole. CONCLUSIONS: The burden of meningococcal disease remains highest in young infants and serogroup B predominates. Vaccines that provide long-term protection early in life have the potential to reduce the burden of meningococcal disease, especially if they provide protection against serogroup B meningococcal disease. C1 [MacNeil, Jessica R.; Pondo, Tracy; Mayer, Leonard W.; Clark, Thomas A.; Cohn, Amanda C.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Bacterial Dis, Atlanta, GA 30333 USA. [Bennett, Nancy] New York State Dept Hlth, Albany, NY USA. [Farley, Monica M.] Emory Univ, Sch Med, Dept Med, Atlanta, GA 30322 USA. [Farley, Monica M.] Atlanta Vet Affairs VA Med Ctr, Atlanta, GA USA. [Harrison, Lee H.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA. [Lynfield, Ruth] Minnesota Dept Hlth, St Paul, MN USA. [Nichols, Megin] New Mexico Dept Hlth, Santa Fe, NM USA. [Petit, Sue] Connecticut Dept Publ Hlth, Hartford, CT USA. [Reingold, Arthur] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA. [Schaffner, William] Vanderbilt Univ, Sch Med, Dept Prevent Med, Nashville, TN 37212 USA. [Thomas, Ann] Oregon Dept Human Serv, Portland, OR USA. RP MacNeil, JR (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,MS C-25, Atlanta, GA 30333 USA. EM jmacneil@cdc.gov FU Centers for Disease Control and Prevention Emerging Infections Program [CI05-026] FX The Active Bacterial Core surveillance sites received funding from the Centers for Disease Control and Prevention Emerging Infections Program cooperative agreement CI05-026. The findings and conclusions in this article are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention NR 27 TC 10 Z9 11 U1 0 U2 5 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD FEB PY 2015 VL 135 IS 2 BP E305 EP E311 DI 10.1542/peds.2014-2035 PG 7 WC Pediatrics SC Pediatrics GA CA1IN UT WOS:000348666300005 PM 25583921 ER PT J AU Sahni, LC Tate, JE Payne, DC Parashar, UD Boom, JA AF Sahni, Leila C. Tate, Jacqueline E. Payne, Daniel C. Parashar, Umesh D. Boom, Julie A. TI Variation in Rotavirus Vaccine Coverage by Provider Location and Subsequent Disease Burden SO PEDIATRICS LA English DT Article ID UNITED-STATES; US CHILDREN; INFANTS; GASTROENTERITIS; PENTAVALENT; DISCHARGE AB BACKGROUND: Rotavirus vaccines were introduced in the United States in 2006. Full-series coverage is lower than for other vaccines, and disease continues to occur. We examined variation in vaccine coverage among provider locations and correlated coverage with the detection of rotavirus in children who sought treatment of severe acute gastroenteritis (AGE). METHODS: Vaccine records of children enrolled in an AGE surveillance program were obtained and children were grouped by the location that administered each child's 2-month vaccines. Cases were children with laboratory-confirmed rotavirus AGE; controls were children with rotavirus-negative AGE or acute respiratory infection. Location-level coverage was calculated using >= 1 dose rotavirus vaccine coverage among controls and classified as low (<40%), medium (>= 40% to <80%), or high (>= 80%). Rotavirus detection rates among patients with AGE were calculated by vaccine coverage category. RESULTS: Of controls, 80.4% (n = 1123 of 1396) received >= 1 dose of rotavirus vaccine from 68 locations. Four (5.9%) locations, including a NICU, were low coverage, 22 (32.3%) were medium coverage, and 42 (61.8%) were high coverage. In low-coverage locations, 31.4% of patients with AGE were rotavirus-positive compared with 13.1% and 9.6% in medium-and high-coverage locations, respectively. Patients with AGE from low-coverage locations had 3.3 (95% confidence interval 2.4-4.4) times the detection rate of rotavirus than patients with AGE from high vaccine coverage locations. CONCLUSIONS: We observed the highest detection of rotavirus disease among locations with low rotavirus vaccine coverage, suggesting that ongoing disease transmission is related to failure to vaccinate. Educational efforts focusing on timely rotavirus vaccine administration to age-eligible infants are needed. C1 [Sahni, Leila C.; Boom, Julie A.] Texas Childrens Hosp, Immunizat Project, Houston, TX 77030 USA. [Tate, Jacqueline E.; Payne, Daniel C.; Parashar, Umesh D.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Atlanta, GA USA. [Boom, Julie A.] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA. RP Sahni, LC (reprint author), 1102 Bates Ave,Ste 1550, Houston, TX 77030 USA. EM lcsahni@texaschildrens.org FU Centers for Disease Control and Prevention [CDC-RFA-CI07-70405ARRA09]; Texas Department of State Health Services; Texas Children's Hospital FX Ms Sahni and Dr Boom were supported by a Centers for Disease Control and Prevention grant awarded to the Texas Department of State Health Services (CDC-RFA-CI07-70405ARRA09: Strengthening the Evidence Base: Epidemiology and Laboratory Capacity for Infectious Diseases [ELC] Rotavirus Vaccine Effectiveness) and a subsequent contract between the Texas Department of State Health Services and Texas Children's Hospital. NR 21 TC 2 Z9 2 U1 0 U2 2 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD FEB PY 2015 VL 135 IS 2 BP E432 EP E439 DI 10.1542/peds.2014-0208 PG 8 WC Pediatrics SC Pediatrics GA CA1IN UT WOS:000348666300020 PM 25583918 ER PT J AU Legro, RS Kunselman, AR Meadows, JW Kesner, JS Krieg, EF Rogers, AM Cooney, RN AF Legro, Richard S. Kunselman, Allen R. Meadows, Juliana W. Kesner, James S. Krieg, Edward F., Jr. Rogers, Ann M. Cooney, Robert N. TI Time-related increase in urinary testosterone levels and stable semen analysis parameters after bariatric surgery in men SO REPRODUCTIVE BIOMEDICINE ONLINE LA English DT Article DE androgens; hypogonadism; obesity; semen; sexual dysfunction; weight loss ID GASTRIC BYPASS-SURGERY; RANDOMIZED CONTROLLED-TRIAL; OBESE MEN; SPERM PARAMETERS; GONADAL-FUNCTION; HYPOGONADISM AB The aim of this prospective cohort study was to determine the time-course in androgen and semen parameters in men after weight loss associated with bariatric surgery. Six men aged 18-40 years, meeting National Institutes of Health bariatric surgery guidelines, were followed between 2005 and 2008. Study visits took place at baseline, then 1, 3, 6 and 12 months after surgery. All men underwent Roux-en-y gastric bypass (RYGB). At each visit, biometric, questionnaire, serum, and urinary specimens and seman analysis were collected. Urinary integrated total testosterone levels increased significantly (P < 0.0001) by 3 months after surgery, and remained elevated throughout the study. Circulating testosterone levels were also higher at 1 and 6 months after surgery, compared with baseline. Serum sex hormone-binding globulin levels were significantly elevated at all time points after surgery (P < 0.01 to P = 0.02). After RYGB surgery, no significant changes occurred in urinary oestrogen metabolites (oestrone 3-glucuronide), serum oestradiol levels, serial semen parameters or male sexual function by questionnaire. A threshold of weight loss is necessary to improve male reproductive function by reversing male hypogonadism, manifested as increased testosterone levels. Further serial semen analyses showed normal ranges for most parameters despite massive weight loss. (C) 2014 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. C1 [Legro, Richard S.; Kunselman, Allen R.; Rogers, Ann M.] Penn State Univ, Coll Med, Hershey, PA 17033 USA. [Meadows, Juliana W.; Kesner, James S.; Krieg, Edward F., Jr.] NIOSH, Div Appl Res & Technol, Cincinnati, OH 45226 USA. [Cooney, Robert N.] SUNY Upstate Med Ctr, Syracuse, NY 13210 USA. RP Legro, RS (reprint author), Penn State Univ, Coll Med, Hershey, PA 17033 USA. EM rsl1@psu.edu FU Pennsylvania Department of Health using Tobacco CURE Funds; National Center for Research Resources; National Center for Advancing Translational Sciences, National Institutes of Health [UL1RR033184]; National Institutes of Health Construction [C06 RR016499] FX This project is funded, in part, under a grant with the Pennsylvania Department of Health using Tobacco CURE Funds, by a Clinical and Translational Science Award from the National Center for Research Resources and the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant UL1RR033184 and a National Institutes of Health Construction Grant C06 RR016499 ( to Pennsylvania State University). The findings and conclusions in this report are those of the authors and do not necessarily represent views of the National Institute for Occupational Safety and Health, the National Institutes of Health, or the Pennsylvania Department of Health. NR 19 TC 2 Z9 2 U1 0 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1472-6483 EI 1472-6491 J9 REPROD BIOMED ONLINE JI Reprod. Biomed. Online PD FEB PY 2015 VL 30 IS 2 BP 150 EP 156 DI 10.1016/j.rbmo.2014.10.014 PG 7 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA CA7GY UT WOS:000349087000008 PM 25498592 ER PT J AU Mazurek, JM White, GE Moorman, JE Storey, E AF Mazurek, Jacek M. White, Gretchen E. Moorman, Jeanne E. Storey, Eileen TI Patient-physician communication about work-related asthma: what we do and do not know SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY LA English DT Article ID THORACIC-SOCIETY STATEMENT; OCCUPATIONAL ASTHMA; CENTERED COMMUNICATION; EXACERBATED ASTHMA; UNITED-STATES; HEALTH; CARE; QUALITY; ADULTS; DEATH AB Background: Effective patient-physician communication is the key component of the patient-physician relationship. Objective: To assess the proportion of ever-employed adults with current asthma who talked about asthma associated with work with their physician or other health professional and to identify factors associated with this communication. Methods: The 2006 to 2010 Behavioral Risk Factor Surveillance System Asthma Call-Back Survey data from 40 states and the District of Columbia for ever-employed adults (>= 18 years old) with current asthma (N = 50,433) were examined. Multivariable logistic regression analyses were conducted to identify factors associated with communication with a health professional about asthma and work. Results: Among ever-employed adults with current asthma, 9.1% were ever told by a physician that their asthma was related to any job they ever had and 11.7% ever told a physician or other health professional that this was the case. When responses to the 2 questions were combined, the proportion of those who communicated with a health professional about asthma and work was 14.7%. Communication with a health professional about asthma and work was associated with age, race or ethnicity, employment, education, income, insurance, and urgent treatment for worsening asthma. Conclusion: A small proportion of patients with asthma might communicate with a health professional about asthma associated with work. Future studies should examine whether patients with asthma ever discussed with a health professional the possibility that their asthma might be related to work to provide information on the frequency of patient-clinician communication about asthma related to work. (C) 2015 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved. C1 [Mazurek, Jacek M.; White, Gretchen E.; Storey, Eileen] NIOSH, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. [Moorman, Jeanne E.] Natl Ctr Environm Hlth, Ctr Dis Control & Prevent, Atlanta, GA USA. RP Mazurek, JM (reprint author), NIOSH, Ctr Dis Control & Prevent, Div Resp Dis Studies, Surveillance Branch, Mailstop HG 900 2, Morgantown, WV 26505 USA. EM JMazurek1@cdc.gov FU Intramural CDC HHS [CC999999] NR 51 TC 1 Z9 2 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1081-1206 EI 1534-4436 J9 ANN ALLERG ASTHMA IM JI Ann. Allergy Asthma Immunol. PD FEB PY 2015 VL 114 IS 2 BP 97 EP U138 DI 10.1016/j.anai.2014.10.022 PG 7 WC Allergy; Immunology SC Allergy; Immunology GA AZ8GZ UT WOS:000348454700006 PM 25492097 ER PT J AU Durand, LO Glew, P Gross, D Kasper, M Trock, S Kim, IK Bresee, JS Donis, R Uyeki, TM Widdowson, MA Azziz-Baumgartner, E AF Durand, Lizefte O. Glew, Patrick Gross, Diane Kasper, Matthew Trock, Susan Kim, Inkyu K. Bresee, Joseph S. Donis, Ruben Uyeki, Timothy M. Widdowson, Marc-Alain Azziz-Baumgartner, Eduardo TI Timing of Influenza A(H5N1) in Poultry and Humans and Seasonal Influenza Activity Worldwide, 2004-2013 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID PATHOGENIC AVIAN INFLUENZA; COLD STRESS; A H5N1; SOUTHEAST-ASIA; RISK-FACTORS; VIRUS H5N1; OUTBREAKS; TEMPERATURE; THAILAND; INFECTION AB Co-circulation of influenza A(H5N1) and seasonal influenza viruses among humans and animals could lead to coinfections, reassortment, and emergence of novel viruses with pandemic potential. We assessed the timing of subtype H5N1 outbreaks among poultry, human H5N1 cases, and human seasonal influenza in 8 countries that reported 97% of all human H5N1 cases and 90% of all poultry H5N1 outbreaks. In these countries, most outbreaks among poultry (7,001/11,331, 62%) and half of human cases (313/625, 50%) occurred during January March. Human H5N1 cases occurred in 167 (45%) of 372 months during which outbreaks among poultry occurred, compared with 59 (10%) of 574 months that had no outbreaks among poultry. Human H5N1 cases also occurred in 59 (22%) of 267 months during seasonal influenza periods. To reduce risk for co-infection, surveillance and control of H5N1 should be enhanced during January March, when H5N1 outbreaks typically occur and overlap with seasonal influenza virus circulation. C1 [Durand, Lizefte O.; Glew, Patrick; Gross, Diane; Trock, Susan; Kim, Inkyu K.; Bresee, Joseph S.; Donis, Ruben; Uyeki, Timothy M.; Widdowson, Marc-Alain] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. [Gross, Diane] WHO, Reg Off Europe, DK-2100 Copenhagen, Denmark. [Kasper, Matthew] US Naval Med Res Unit 6, Lima, Peru. RP Azziz-Baumgartner, E (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop A32, Atlanta, GA 30329 USA. EM eha9@cdc.gov NR 38 TC 5 Z9 5 U1 4 U2 18 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD FEB PY 2015 VL 21 IS 2 BP 202 EP 208 DI 10.3201/eid2102.140877 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AZ8WC UT WOS:000348491400002 PM 25625302 ER PT J AU Nix, EB Williams, K Cox, AD St Michael, F Romero-Steiner, S Schmidt, DS McCready, WG Ulanova, M AF Nix, Eli B. Williams, Kylie Cox, Andrew D. St Michael, Frank Romero-Steiner, Sandra Schmidt, Daniel S. McCready, William G. Ulanova, Marina TI Naturally Acquired Antibodies against Haemophilus influenzae Type a in Aboriginal Adults, Canada SO EMERGING INFECTIOUS DISEASES LA English DT Article ID CONJUGATE VACCINE; HEMOPHILUS-INFLUENZAE; B CONJUGATE; CAPSULAR POLYSACCHARIDE; DISEASE; EPIDEMIOLOGY; POPULATION; SEROTYPE; PEOPLE; MENINGITIS AB In the post-Haemophilus influenzae type b (Hib) vaccine era that began in the 1980's, H. influenzae type a (Hia) emerged as a prominent cause of invasive disease in North American Aboriginal populations. To test whether a lack of naturally acquired antibodies may underlie increased rates of invasive Hia disease, we compared serum bactericidal activity against Hia and Hib and IgG and IgM against capsular polysaccharide between Canadian Aboriginal and non-Aboriginal healthy and immunocompromised adults. Both healthy and immunoconnpromised Aboriginal adults exhibited significantly higher bactericidal antibody titers against Hia than did non-Aboriginal adults (p = 0.042 and 0.045 respectively), with no difference in functional antibody activity against Hib. IgM concentrations against Hia were higher than IgG in most study groups; the inverse was true for antibody concentrations against Hib. Our results indicate that Aboriginal adults possess substantial serum bactericidal activity against Hia that is mostly due to IgM antibodies. The presence of sustained IgM against Hia suggests recent Hia exposure. C1 [Nix, Eli B.; Williams, Kylie; McCready, William G.; Ulanova, Marina] Northern Ontario Sch Med, Thunder Bay, ON, Canada. [Cox, Andrew D.; St Michael, Frank] Natl Res Council Canada, Ottawa, ON, Canada. [Romero-Steiner, Sandra; Schmidt, Daniel S.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Ulanova, M (reprint author), Lakehead Univ, Northern Ontario Sch Med, MS-3006,955 Oliver Rd, Thunder Bay, ON P7B 5E1, Canada. EM mulanova@nosm.ca FU Northern Ontario Academic Medicine Association; Canadian Institutes of Health Research FX This study was supported by the Northern Ontario Academic Medicine Association and the Canadian Institutes of Health Research post-doctoral fellowship awarded to E.B.N. NR 40 TC 1 Z9 2 U1 3 U2 10 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD FEB PY 2015 VL 21 IS 2 BP 273 EP 279 DI 10.3201/eid2102.140722 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AZ8WC UT WOS:000348491400011 PM 25626129 ER PT J AU Olsen, SJ Campbell, AP Supawat, K Liamsuwan, S Chotpitayasunondh, T Laptikulthum, S Viriyavejakul, A Tantirittisak, T Tunlayadechanont, S Visudtibhan, A Vasiknanonte, P Janjindamai, S Boonluksiri, P Rajborirug, K Watanaveeradej, V Khetsuriani, N Dowell, SF AF Olsen, Sonja J. Campbell, Angela P. Supawat, Krongkaew Liamsuwan, Sahas Chotpitayasunondh, Tawee Laptikulthum, Somsak Viriyavejakul, Akravudh Tantirittisak, Tasanee Tunlayadechanont, Supoch Visudtibhan, Anannit Vasiknanonte, Punnee Janjindamai, Supachai Boonluksiri, Pairoj Rajborirug, Kiatsak Watanaveeradej, Veerachai Khetsuriani, Nino Dowell, Scott F. CA Thailand Encephalitis Surveillance TI Infectious Causes of Encephalitis and Meningoencephalitis in Thailand, 2003-2005 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID CENTRAL-NERVOUS-SYSTEM; MYCOPLASMA-PNEUMONIAE; VIRAL ETIOLOGIES; DENGUE INFECTION; NIPAH VIRUS; CHILDREN; DISEASE; MANIFESTATIONS; EPIDEMIC; OUTBREAK C1 [Olsen, Sonja J.; Dowell, Scott F.] Thailand Minist Publ Hlth US CDC Collaborat, Nonthaburi, Thailand. [Olsen, Sonja J.; Campbell, Angela P.; Khetsuriani, Nino; Dowell, Scott F.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Liamsuwan, Sahas; Chotpitayasunondh, Tawee] Queen Sirikit Natl Inst Child Hlth, Nonthaburi, Thailand. [Laptikulthum, Somsak] Rajvithi Hosp, Bangkok, Thailand. [Viriyavejakul, Akravudh; Tantirittisak, Tasanee] Prasat Neurol Inst Thailand, Bangkok, Thailand. [Tunlayadechanont, Supoch; Visudtibhan, Anannit] Ramathibodi Hosp, Bangkok, Thailand. [Vasiknanonte, Punnee; Janjindamai, Supachai] Prince Songkhla Univ Hosp, Hat Yai, Thailand. [Boonluksiri, Pairoj; Rajborirug, Kiatsak] Hat Yai Hosp, Hat Yai, Thailand. [Watanaveeradej, Veerachai] Phramongkutklao Hosp, Bangkok, Thailand. RP Olsen, SJ (reprint author), Care of Henry R, Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop E03, Atlanta, GA 30329 USA. FU US CDC FX This study was supported by funding from the US CDC. NR 40 TC 3 Z9 3 U1 0 U2 4 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD FEB PY 2015 VL 21 IS 2 BP 280 EP 289 DI 10.3201/eid2102.140291 PG 10 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AZ8WC UT WOS:000348491400012 PM 25627940 ER PT J AU Manrique-Saide, P Che-Mendoza, A Barrera-Perez, M Guillermo-May, G Herrera-Bojorquez, J Dzul-Manzanilla, F Gutierrez-Castro, C Lenhart, A Vazquez-Prokopec, G Sommerfeld, J McCall, PJ Kroeger, A Arredondo-Jimenez, JI AF Manrique-Saide, Pablo Che-Mendoza, Azael Barrera-Perez, Mario Guillermo-May, Guillermo Herrera-Bojorquez, Josue Dzul-Manzanilla, Felipe Gutierrez-Castro, Cipriano Lenhart, Audrey Vazquez-Prokopec, Gonzalo Sommerfeld, Johannes McCall, Philip J. Kroeger, Axel Arredondo-Jimenez, Juan I. TI Use of Insecticide-Treated House Screens to Reduce Infestations of Dengue Virus Vectors, Mexico SO EMERGING INFECTIOUS DISEASES LA English DT Article ID CURTAINS; THAILAND AB Dengue prevention efforts rely on control of virus vectors. We investigated use of insecticide-treated screens permanently affixed to windows and doors in Mexico and found that the screens significantly reduced infestations of Aedes aegypti mosquitoes in treated houses. Our findings demonstrate the value of this method for dengue virus vector control. C1 [Manrique-Saide, Pablo; Barrera-Perez, Mario; Guillermo-May, Guillermo; Herrera-Bojorquez, Josue] Univ Autonoma Yucatan, Merida, Mexico. [Che-Mendoza, Azael] Gobierno Estado Yucatan, Serv Salud Yucatan, Merida, Mexico. [Dzul-Manzanilla, Felipe; Gutierrez-Castro, Cipriano] Serv Estatales Salud Guerrero, Chilpancingo, Mexico. [Lenhart, Audrey] Ctr Dis Control & Prevent, Atlanta, GA USA. [Vazquez-Prokopec, Gonzalo] Emory Univ, Atlanta, GA 30322 USA. [Sommerfeld, Johannes; Kroeger, Axel] WHO, CH-1211 Geneva, Switzerland. [McCall, Philip J.] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England. [Arredondo-Jimenez, Juan I.] Ctr Nacl Programas Prevent & Control Enfermedades, Mexico City, DF, Mexico. RP Arredondo-Jimenez, JI (reprint author), Univ Autonoma Nuevo Leon, Pedro de Alba S-N,Ciudad Univ, San Nicolas De Los Garza 66450, Nuevo Leon, Mexico. EM jiarre1@gmail.co OI Kroeger, Axel/0000-0001-8438-2904 FU United Nations Development Programme/World Bank/WHO Special Program for Research and Training in Tropical Diseases/International Development Research Center [A70585]; FOMIX CONACYT-Guerrero [GUE-2008-02-108686] FX Financial support was provided by the United Nations Development Programme/World Bank/WHO Special Program for Research and Training in Tropical Diseases/International Development Research Center (project no. A70585) and FOMIX CONACYT-Guerrero (project GUE-2008-02-108686). NR 14 TC 8 Z9 9 U1 2 U2 10 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD FEB PY 2015 VL 21 IS 2 BP 308 EP 311 DI 10.3201/eid2102.140533 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AZ8WC UT WOS:000348491400016 PM 25625483 ER PT J AU Ching, PKG de los Reyes, VC Sucaldito, MN Tayag, E Columna-Vingno, AB Malbas, FF Bolo, GC Sejvar, JJ Eagles, D Playford, G Dueger, E Kaku, Y Morikawa, S Kuroda, M Marsh, GA McCullough, S Foxwell, AR AF Ching, Paola Katrina G. Carr de los Reyes, Vikki Nemia Sucaldito, Maria Tayag, Enrique Baby Columna-Vingno, Alah Malbas, Fedelino F., Jr. Bolo, Gilbert C., Jr. Sejvar, James J. Eagles, Debbie Playford, Geoffrey Dueger, Erica Kaku, Yoshihiro Morikawa, Shigeru Kuroda, Makoto Marsh, Glenn A. McCullough, Sam Foxwell, A. Ruth TI Outbreak of Henipavirus Infection, Philippines, 2014 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID NIPAH VIRUS; EMERGING PARAMYXOVIRUSES; HENDRA VIRUS; ENCEPHALITIS; BANGLADESH; BATS AB During 2014, henipavirus infection caused severe illness among humans and horses in southern Philippines; fatality rates among humans were high. Horse-to-human and human-to-human transmission occurred. The most likely source of horse infection was fruit bats. Ongoing surveillance is needed for rapid diagnosis, risk factor investigation, control measure implementation, and further virus characterization. C1 [Ching, Paola Katrina G.; Carr de los Reyes, Vikki; Nemia Sucaldito, Maria; Tayag, Enrique; Malbas, Fedelino F., Jr.] Dept Hlth, Manila, Philippines. [Baby Columna-Vingno, Alah] Ctr Hlth Dev Reg XII, Gen Santos, Philippines. [Bolo, Gilbert C., Jr.] Dept Agr, Manila, Philippines. [Sejvar, James J.; Eagles, Debbie; Playford, Geoffrey; Dueger, Erica; Foxwell, A. Ruth] WHO, Manila, Philippines. [Sejvar, James J.; Dueger, Erica] Ctr Dis Control & Prevent, Atlanta, GA USA. [Eagles, Debbie; Marsh, Glenn A.; McCullough, Sam] Australian Anim Hlth Lab, Geelong, Vic, Australia. [Playford, Geoffrey] Univ Queensland, Brisbane, Qld, Australia. [Kaku, Yoshihiro; Morikawa, Shigeru; Kuroda, Makoto] Natl Inst Infect Dis, Tokyo, Japan. [Foxwell, A. Ruth] Australian Natl Univ, Canberra, ACT, Australia. RP Foxwell, AR (reprint author), 40 Endeavour St, Red Hill, ACT 2603, Australia. EM ruth.foxwell@grnail.com RI McCullough, Sam/H-7987-2013 NR 15 TC 17 Z9 17 U1 1 U2 20 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD FEB PY 2015 VL 21 IS 2 BP 328 EP 331 DI 10.3201/eid2102.141433 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AZ8WC UT WOS:000348491400021 PM 25626011 ER PT J AU Miller, LA Colby, K Manning, SE Hoenig, D McEvoy, E Montgomery, S Mathison, B de Almeida, M Bishop, H Dasilva, A Sears, S AF Miller, Leigh Ann Colby, Kate Manning, Susan E. Hoenig, Donald McEvoy, Elizabeth Montgomery, Susan Mathison, Blaine de Almeida, Marcos Bishop, Henry Dasilva, Alexandre Sears, Stephen TI Ascariasis in Humans and Pigs on Small-Scale Farms, Maine, USA, 2010-2013 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID UNITED-STATES; INFECTIONS; AMERICA AB Ascaris is a genus of parasitic nematodes that can cause infections in humans and pigs. During 2010-2013, we identified 14 cases of ascariasis in persons who had contact with pigs in Maine, USA. Ascaris spp. are important zoonotic pathogens, and prevention measures are needed, including health education, farming practice improvements, and personal and food hygiene. C1 [Miller, Leigh Ann; Colby, Kate; Manning, Susan E.; Sears, Stephen] Maine Ctr Dis Control & Dis, Maine Dept Hlth & Human Serv, Augusta, ME 04333 USA. [Miller, Leigh Ann; Manning, Susan E.; Montgomery, Susan; Mathison, Blaine; de Almeida, Marcos; Bishop, Henry; Dasilva, Alexandre] Ctr Dis Control & Prevent, Atlanta, GA USA. [Colby, Kate] Univ So Maine, Portland, ME 04103 USA. [Hoenig, Donald; McEvoy, Elizabeth] Maine Dept Agr Conservat & Forestry, Augusta, GA USA. RP Miller, LA (reprint author), Maine Ctr Dis Control & Dis, Div Infect Dis, 286 Water St,8th Fl, Augusta, ME 04333 USA. EM wip1@cdc.gov NR 13 TC 4 Z9 4 U1 1 U2 8 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD FEB PY 2015 VL 21 IS 2 BP 332 EP 334 DI 10.3201/eid2102.140048 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AZ8WC UT WOS:000348491400022 PM 25626125 ER PT J AU Praphasiri, P Owusu, JT Thammathitiwat, S Ditsungnoen, D Boonmongkon, P Sangwichian, O Prasert, K Srihapanya, S Sornwong, K Kerdsin, A Dejsirilert, S Baggett, HC Olsen, SJ AF Praphasiri, Prabda Owusu, Jocelynn T. Thammathitiwat, Somsak Ditsungnoen, Darunee Boonmongkon, Pimpawan Sangwichian, Ornuma Prasert, Kriengkrai Srihapanya, Sankhom Sornwong, Kanlaya Kerdsin, Anusak Dejsirilert, Surang Baggett, Henry C. Olsen, Sonja J. TI Streptococcus suis Infection in Hospitalized Patients, Nakhon Phanom Province, Thailand SO EMERGING INFECTIOUS DISEASES LA English DT Article ID RURAL THAILAND; PATHOGEN AB In Nakhon Phanom, Thailand, we identified 38 hospitalized patients with Streptococcus suis infection during 2006-2012. Deafness developed in 12 patients; none died. Thirty-five reported recent exposure to pigs/pork. Annual incidence was 0.1-2.2 cases/100,000 population (0.2-3.2 in persons >= 20 years of age). Clinicians should consider S. suis infection in areas where pig exposure is common. C1 [Praphasiri, Prabda; Owusu, Jocelynn T.; Thammathitiwat, Somsak; Ditsungnoen, Darunee; Sangwichian, Ornuma; Baggett, Henry C.; Olsen, Sonja J.] Thailand Minist Publ Hlth, US Ctr Dis Control & Prevent Collaborat, Nonthaburi, Thailand. [Praphasiri, Prabda; Boonmongkon, Pimpawan] Mahidol Univ, Nakhon Pathom, Thailand. [Prasert, Kriengkrai; Srihapanya, Sankhom; Sornwong, Kanlaya] Nakhon Phanom Prov Hlth Off, Nakhon Phanom, Thailand. [Kerdsin, Anusak; Dejsirilert, Surang] Thailand Minist Publ Hlth, Nonthaburi, Thailand. [Baggett, Henry C.; Olsen, Sonja J.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Praphasiri, P (reprint author), Minist Publ Hlth, Thailand MOPH US CDC Collaborat, DDC Bldg 7,4th Fl,Soi 4,Tivanon Rd, Nonthaburi 11000, Thailand. EM hpu3@cdc.gov OI Kerdsin, Anusak/0000-0003-1055-3656 FU US Centers for Disease Control and Preventon; Ministry of Public Health, Thailand; Association of Schools and Programs of Public Health [5U19GH000004, U36/CCU300430] FX The US Centers for Disease Control and Preventon, the Ministry of Public Health, Thailand, and the Association of Schools and Programs of Public Health (cooperative agreements 5U19GH000004 and U36/CCU300430) provided funding for this study. NR 15 TC 3 Z9 3 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD FEB PY 2015 VL 21 IS 2 BP 345 EP 348 DI 10.3201/eid2102.140961 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AZ8WC UT WOS:000348491400026 PM 25625540 ER PT J AU Sazzad, HMS Luby, SP Stroher, U Daszak, P Sultana, S Afroj, S Rahman, M Gurley, ES AF Sazzad, Hossain M. S. Luby, Stephen P. Stroeher, Ute Daszak, Peter Sultana, Sharmin Afroj, Sayma Rahman, Mahmudur Gurley, Emily S. TI Exposure-Based Screening for Nipah Virus Encephalitis, Bangladesh SO EMERGING INFECTIOUS DISEASES LA English DT Article ID TRANSMISSION; OUTBREAK AB We measured the performance of exposure screening questions to identify Nipah virus encephalitis in hospitalized encephalitis patients during the 2012-13 Nipah virus season in Bangladesh. The sensitivity (93%), specificity (82%), positive predictive value (37%), and negative predictive value (99%) results suggested that screening questions could more quickly identify persons with Nipah virus encephalitis. C1 [Sazzad, Hossain M. S.; Afroj, Sayma; Gurley, Emily S.] Icddr B, Dhaka 1212, Bangladesh. [Luby, Stephen P.] Stanford Univ, Stanford, CA 94305 USA. [Stroeher, Ute] Ctr Dis Control & Prevent, Atlanta, GA USA. [Daszak, Peter] EcoHth Alliance, New York, NY USA. [Sultana, Sharmin; Rahman, Mahmudur] Inst Epidemiol Dis Control & Res, Dhaka, Bangladesh. RP Sazzad, HMS (reprint author), Icddr B, Ctr Communicable Dis, 68 Shaheed Tajuddin Ahmed Sarani, Dhaka 1212, Bangladesh. EM sazzad@icddrb.org RI Gurley, Emily/B-7903-2010; OI Gurley, Emily/0000-0002-8648-9403; Luby, Stephen/0000-0001-5385-899X FU US National Institutes of Health (NIH) [07-015-0712-52200]; National Science Foundation/NIH Ecology and Evolution of Infectious Diseases from the Fogarty International Center [2R01-TW005869] FX The study was funded by the US National Institutes of Health (NIH), grant no. 07-015-0712-52200 (Bangladesh-NIH/Emerging Infectious Diseases), and National Science Foundation/NIH Ecology and Evolution of Infectious Diseases grant no. 2R01-TW005869 from the Fogarty International Center. icddr,b acknowledges with gratitude the commitment of the US Centers for Disease Control and Prevention, NIH, and Government of Bangladesh for their research efforts. icddr,b is also thankful to the Governments of Australia, Bangladesh, Canada, Sweden, and the United Kingdom for providing core/unrestricted support. NR 14 TC 0 Z9 0 U1 0 U2 5 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD FEB PY 2015 VL 21 IS 2 BP 349 EP 351 DI 10.3201/eid2102.141129 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AZ8WC UT WOS:000348491400027 PM 25625615 ER PT J AU Semaan, S AF Semaan, Salaam TI Cubism and Research Synthesis SO EMERGING INFECTIOUS DISEASES LA English DT Editorial Material ID HEALTH C1 [Semaan, Salaam] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. RP Semaan, S (reprint author), Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Mailstop E07, Atlanta, GA 30329 USA. EM svs5@cdc.gov NR 6 TC 1 Z9 1 U1 1 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD FEB PY 2015 VL 21 IS 2 BP 386 EP 387 DI 10.3201/eid2102.AC2102 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AZ8WC UT WOS:000348491400042 PM 25786275 ER PT J AU Shults, RA West, BA AF Shults, Ruth A. West, Bethany A. TI ATV riding and helmet use among youth aged 12-17 years, USA, 2011: results from the YouthStyles survey SO INJURY PREVENTION LA English DT Article ID TERRAIN VEHICLE INJURIES; UNITED-STATES; USE PATTERNS; RISK-TAKING; CHILDREN; SAFETY; ADOLESCENCE; LEGISLATION; STRATEGIES; SCIENCE AB Background National estimates of all-terrain vehicle (ATV) riding patterns among youth in the USA are lacking. Methods We analysed the 2011 YouthStyles survey to estimate the proportion of 12-17 year olds in the USA who had ridden an ATV at least once during the past 12 months and summarise their patterns of helmet use. Results Of the 831 youth respondents, an estimated 25% reported riding an ATV at least once during the past year. The proportion of youth living outside of a Metropolitan Statistical Area who reported riding an ATV was twice that of those living inside of a Metropolitan Statistical Area. Males and females reported similar proportions of riding at least once during the past year, but among riders, the proportion of males who rode >= 6 times was triple that of females. Only 45% of riders reported always wearing a helmet, and 25% reported never wearing a helmet. The most frequent riders had the lowest consistent helmet use, with 8 of 10 youth who rode >= 6 times during the past year not always wearing a helmet. Conclusions ATV riding appears to remain popular among youth in the USA, particularly in rural areas, and consistent helmet use while riding is low. A more thorough understanding of gender differences in ATV riding patterns among youth and perceived risks and benefits of both safe and unsafe riding practices might help inform future ATV injury prevention efforts. C1 [Shults, Ruth A.; West, Bethany A.] CDC, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA. RP Shults, RA (reprint author), Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, 4770 Buford Highway NE,MS F-62, Atlanta, GA 30341 USA. EM rshults@cdc.gov NR 39 TC 0 Z9 0 U1 1 U2 2 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1353-8047 EI 1475-5785 J9 INJURY PREV JI Inj. Prev. PD FEB PY 2015 VL 21 IS 1 BP 10 EP 14 DI 10.1136/injuryprev-2013-041138 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ5SQ UT WOS:000348280400007 PM 24916683 ER PT J AU Tejada-Strop, A Drobeniuc, J Mixson-Hayden, T Forbi, JC Le, NT Li, LX Mei, J Terrault, N Kamili, S AF Tejada-Strop, Alexandra Drobeniuc, Jan Mixson-Hayden, Tonya Forbi, Joseph C. Ngoc-Thao Le Li, Lixia Mei, Joanne Terrault, Norah Kamili, Saleem TI Disparate detection outcomes for anti-HCV IgG and HCV RNA in dried blood spots SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE Hepatitis C antibodies; Blood specimen collection; Real-time polymerase chain reaction; Molecular typing; Genotype ID HEPATITIS-C VIRUS; HUMAN-IMMUNODEFICIENCY-VIRUS; UNITED-STATES; B-VIRUS; PLASMA; INFECTIONS; SEROLOGY; SPECIMENS; SAMPLES AB Dried blood spots (DBS) expedite the collection, storage and shipping of blood samples, thereby facilitating large-scale serologic studies. We evaluated the sensitivity of anti-HCV IgG testing and HCV-RNA quantitation using freshly prepared and stored DBS derived from HCV-infected patients. Protocols for elution were optimized using DBS prepared from plasma of 52 HCV-infected persons and 51 uninfected persons (control DBS), then applied to DBS from 33 chronic hepatitis C patients that had been stored at -20 degrees C for 5 years (stored DBS). Control and stored DBS, and their corresponding plasma, were processed for anti-HCV IgG testing using the VITROS chemiluminescence assay (CIA) and the HCV 3.0 enzyme immunoassay (EIA) (Ortho-Clinical Diagnostics), and for HCV RNA quantitation by quantitative (q) RT-PCR. HCV genotyping was conducted by nucleotide sequencing. The sensitivity of CIA and EIA in control DBS was 92% and 90%, respectively, compared to 100% and 97%, respectively, in stored DBS. The sensitivity of HCV RNA detection was 88% in control DBS, compared to 36% in stored DBS. Specificity was 100% for all the assays in both control and stored DBS. Genotypes 1, 2 and 3 were detected in 16 (62%), 6(23.1%), and 4(15.3%) samples, respectively. Sequences generated from DBS and their corresponding plasma samples were identical. Whereas the sensitivity of anti-HCV IgG detection in stored DBS was equivalent to that in recently prepared DBS, the sensitivity of HCV RNA detection was markedly lower in stored PBS compared to recently prepared DBS. Stored DBS may be reliably used for anti-HCV detection but for HCV-RNA-based testing freshly prepared DBS is preferable to stored DBS. Published by Elsevier B.V. C1 [Tejada-Strop, Alexandra; Drobeniuc, Jan; Mixson-Hayden, Tonya; Forbi, Joseph C.; Li, Lixia; Mei, Joanne; Kamili, Saleem] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. [Terrault, Norah] Univ Calif San Francisco, Med Ctr, San Francisco, CA 94143 USA. [Ngoc-Thao Le] Alaska Hlth & Social Serv, Juneau, AK 99811 USA. RP Drobeniuc, J (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd, Atlanta, GA 30329 USA. EM jqd6@cdc.gov FU Research Project Cooperative Agreement [5 U01 CI000309-02]; Department of Energy; CDC FX The authors would like to acknowledge Natasha Khudyakov, Aufra Araujo, Guo-liang Xia at the Centers for Disease Control and Prevention, and Rom Kuras at the University of California San Francisco for technical assistance. This research was supported by Research Project Cooperative Agreement Grant number 5 U01 CI000309-02, and in part by an appointment to the Research Participation Program at CDC administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the Department of Energy and CDC. NR 20 TC 4 Z9 4 U1 0 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 EI 1879-0984 J9 J VIROL METHODS JI J. Virol. Methods PD FEB PY 2015 VL 212 BP 66 EP 70 DI 10.1016/j.jviromet.2014.10.018 PG 5 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA CA0PY UT WOS:000348620400012 PM 25445800 ER PT J AU Kogan, MD Barfield, W Kroelinger, C AF Kogan, Michael D. Barfield, Wanda Kroelinger, Charlan TI The Evolving Role of Leadership and Change in Maternal and Child Health Epidemiology SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article ID DEPARTMENTS; CAPACITY; STATE C1 [Kogan, Michael D.] US Hlth Resources & Serv Adm, Maternal & Child Hlth Bur, Rockville, MD 20857 USA. [Barfield, Wanda; Kroelinger, Charlan] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Kogan, MD (reprint author), US Hlth Resources & Serv Adm, Maternal & Child Hlth Bur, 5600 Fishers Lane,Room 18-41, Rockville, MD 20857 USA. EM mkogan@hrsa.gov FU Intramural CDC HHS [CC999999] NR 29 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 EI 1573-6628 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD FEB PY 2015 VL 19 IS 2 SI SI BP 247 EP 251 DI 10.1007/s10995-014-1575-z PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ6TP UT WOS:000348353600006 PM 25078480 ER PT J AU Strickland, BB Jones, JR Newacheck, PW Bethell, CD Blumberg, SJ Kogan, MD AF Strickland, Bonnie B. Jones, Jessica R. Newacheck, Paul W. Bethell, Christina D. Blumberg, Stephen J. Kogan, Michael D. TI Assessing Systems Quality in a Changing Health Care Environment: The 2009-10 National Survey of Children with Special Health Care Needs SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Children with special health care needs; Health care quality; Systems of care; Access; Disparities ID UNITED-STATES; SERVICES; YOUTH AB To provide a national, population-based assessment of the quality of the health care system for children and youth with special health care needs using a framework of six health care system quality indicators. 49,242 interviews with parents of children with special health care needs from the 2009-10 National Survey of Children with Special Health Care Needs (NS-CSHCN) were examined to determine the extent to which CSHCN had access to six quality indicators of a well-functioning system of services. Criteria for determining access to each indicator were established and applied to the survey data to estimate the proportion of CSHCN meeting each quality indicator by socio-demographic status and functional limitations. 17.6 % of CSHCN received care consistent with all six quality indicators. Results for each component of the system quality framework ranged from a high of 70.3 % of parents reporting that they shared decision-making with healthcare providers to a low of 40 % of parents reporting receipt of services needed for transition to adult health care. Attainment rates were lower for CSHCN of minority racial and ethnic groups, those residing in households where English was not the primary language, those in lower income households, and those most impacted by their health condition. Only a small proportion of CSHCN receive all identified attributes of a high-quality system of services. Moreover, significant disparities exist whereby those most impacted by their conditions and those in traditionally disadvantaged groups are served least well by the current system. A small proportion of CSHCN appear to remain essentially outside of the system, having met few if any of the elements studied. C1 [Strickland, Bonnie B.; Jones, Jessica R.; Kogan, Michael D.] US Hlth Resources & Serv Adm, Maternal & Child Hlth Bur, Rockville, MD 20857 USA. [Newacheck, Paul W.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Bethell, Christina D.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Blumberg, Stephen J.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. RP Strickland, BB (reprint author), US Hlth Resources & Serv Adm, Maternal & Child Hlth Bur, Rockville, MD 20857 USA. EM bstrickland@hrsa.gov; jjones@hrsa.gov; Paul.Newacheck@ucsf.edu; cbethell@cahmi.org; Swb5@CDC.GOV; mkogan@hrsa.gov FU Intramural CDC HHS [CC999999] NR 40 TC 7 Z9 7 U1 0 U2 5 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 EI 1573-6628 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD FEB PY 2015 VL 19 IS 2 SI SI BP 353 EP 361 DI 10.1007/s10995-014-1517-9 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ6TP UT WOS:000348353600019 PM 24912943 ER PT J AU Sauber-Schatz, EK Sappenfield, WM Shapiro-Mendoza, CK AF Sauber-Schatz, Erin K. Sappenfield, William M. Shapiro-Mendoza, Carrie K. TI Comprehensive Review of Sleep-Related Sudden Unexpected Infant Deaths and Their Investigations: Florida 2008 SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Sudden unexpected infant death; SIDS; Sleep; Infant death; Florida; Suffocation ID ENVIRONMENT; RECOMMENDATIONS; EXPANSION; TRENDS; SIDS; BED AB To describe 2008 Florida sleep-related sudden unexpected infant deaths (SUIDs) by describing (a) percentage distribution of medical examiner (ME) cause-of-death determinations; (b) mortality rates by maternal and infant characteristics; (c) prevalence of selected suffocation or sudden infant death syndrome (SIDS) risk and protective factors; (d) frequency of selected scene investigation and autopsy components (including extent of missing data); and (e) percentage with public health program contact. In this population-based study, we identified sleep-related SUIDs occurring among Florida residents from the 2008-linked Florida infant death and birth certificates. Information about the circumstances of death was abstracted from ME, law enforcement, and hospital records. We used frequencies and percentages to describe characteristics of sleep-related SUID cases. Of 215 sleep-related SUID cases, MEs identified 47.9 % as accidental suffocation and strangulation in bed, 35.4 % as unknown or undetermined cause, and 16.7 % as SIDS. Sleep-related SUID most frequently occurred in an adult bed (n = 108; 50.2 %). At death, 82.4 % of sleep-related SUIDs had a parts per thousand yen1 suffocation or SIDS risk factor with 54.4 % infants sharing a sleep surface, 38.1 % placed nonsupine, 24.2 % placed on a pillow, and 10.2 % having head covering. Missing data frequently resulted from incomplete scene investigation and autopsy components. SUID contributed to a parts per thousand yen1 in seven Florida infant deaths in 2008. Approximately 80 % of sleep-related SUIDs were reported among infants placed in unsafe sleeping environments. Effective interventions are needed to promote safe sleep among caregivers of Florida infants. These interventions must reach infant caregivers at highest risk and change unsafe sleep practices. The substantial percentage of missing investigation data reinforces the need for standardized reporting. C1 [Sauber-Schatz, Erin K.] Ctr Dis Control & Prevent, Epidem Intelligence Serv Field Assignments Branch, Atlanta, GA 30341 USA. [Sauber-Schatz, Erin K.; Sappenfield, William M.] Florida Dept Hlth, Div Community Hlth Promot, Bur Family Hlth Serv, Tallahassee, FL USA. [Sauber-Schatz, Erin K.] Ctr Dis Control & Prevent, Div Unintent Injury, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA. [Sauber-Schatz, Erin K.] US Publ Hlth Serv Commissioned Corps, Washington, DC USA. [Sappenfield, William M.] Univ S Florida, Coll Publ Hlth, Dept Community & Family Hlth, Tampa, FL USA. [Shapiro-Mendoza, Carrie K.] Ctr Dis Control & Prevent, Div Reprod Hlth, Maternal & Infant Hlth Branch, Atlanta, GA 30341 USA. RP Sauber-Schatz, EK (reprint author), Ctr Dis Control & Prevent, Div Unintent Injury, Natl Ctr Injury Prevent & Control, Mailstop F-62,4770 Buford Highway NE, Atlanta, GA 30341 USA. EM ige7@cdc.gov FU PHS HHS [H18MC00010] NR 26 TC 5 Z9 5 U1 0 U2 5 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 EI 1573-6628 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD FEB PY 2015 VL 19 IS 2 SI SI BP 381 EP 390 DI 10.1007/s10995-014-1520-1 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ6TP UT WOS:000348353600022 PM 24898690 ER PT J AU Lundquist, J Xu, Z Barfield, W Elo, I AF Lundquist, Jennifer Xu, Zhun Barfield, Wanda Elo, Irma TI Do Black-White Racial Disparities in Breastfeeding Persist in the Military Community? SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Breastfeeding; Race disparities; Military ID UNITED-STATES; RACIAL/ETHNIC DIFFERENCES; HEALTH; WOMEN; POPULATION; DURATION; MOTHERS; MILK AB We conduct a comparative analysis of breastfeeding behavior between military and civilian-affiliated mothers. Our focus is on African American mothers among whom breastfeeding rates are lowest. The military context may mitigate conditions associated with low breastfeeding prevalence by (a) providing stable employment and educational opportunities to populations who face an otherwise poor labor market and (b) providing universal healthcare that includes breastfeeding consultation. Using pregnancy risk assessment monitoring system (PRAMS) data for which we received special permission from each state to flag military affiliation, we analyze civilians and military affiliate in breastfeeding initiation using logistic regression and breastfeeding duration using Cox proportional hazard analysis. We find that breastfeeding is more prevalent among all women in the military setting and that the black-white gap in breastfeeding duration common among civilians is significantly reduced among military affiliates. Breastfeeding is a crucial component of maternal and child health and eliminating racial disparities in its prevalence is a public health priority. This study is the first to identify the military as an important institutional context that deserves closer examination to glean potential policy implications for civilian society. C1 [Lundquist, Jennifer] Univ Massachusetts, ISSR, Amherst, MA 01003 USA. [Xu, Zhun] Renmin Univ China, Beijing, Peoples R China. [Barfield, Wanda] CDC, Div Reprod Hlth, Atlanta, GA 30333 USA. [Elo, Irma] Univ Penn, Populat Ctr, Philadelphia, PA 19104 USA. RP Lundquist, J (reprint author), Univ Massachusetts, ISSR, Amherst, MA 01003 USA. EM lundquist@soc.umass.edu NR 27 TC 2 Z9 2 U1 0 U2 2 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 EI 1573-6628 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD FEB PY 2015 VL 19 IS 2 SI SI BP 419 EP 427 DI 10.1007/s10995-014-1524-x PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ6TP UT WOS:000348353600026 PM 24894729 ER PT J AU Whitfield, GP Kohrt, WM Gabriel, KKP Rahbar, MH Kohl, HW AF Whitfield, Geoffrey P. Kohrt, Wendy M. Gabriel, Kelley K. Pettee Rahbar, Mohammad H. Kohl, Harold W., III TI Bone Mineral Density across a Range of Physical Activity Volumes: NHANES 2007-2010 SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE EPIDEMIOLOGY; GENERAL POPULATION RESEARCH; EXERCISE; DXA ID LONG-DISTANCE RUNNERS; MASS; MECHANISMS; CYCLISTS; ESTROGEN; HEALTH AB Introduction The association between aerobic physical activity volume and bone mineral density (BMD) is not completely understood. The purpose of this study was to clarify the association between BMD and aerobic activity across a broad range of activity volumes, particularly volumes between those recommended in the 2008 Physical Activity Guidelines for Americans and those of trained endurance athletes. Methods Data from the 2007-2010 National Health and Nutrition Examination Survey were used to quantify the association between reported physical activity and BMD at the lumbar spine and proximal femur across the entire range of activity volumes reported by US adults. Participants were categorized into multiples of the minimum guideline-recommended volume based on reported moderate- and vigorous-intensity leisure activity. Lumbar and proximal femur BMD were assessed with dual-energy x-ray absorptiometry. Results Among women, multivariable-adjusted linear regression analyses revealed no significant differences in lumbar BMD across activity categories, whereas proximal femur BMD was significantly higher among those who exceeded the guidelines by 2-4 times than those who reported no activity. Among men, multivariable-adjusted BMD at both sites neared its highest values among those who exceeded the guidelines by at least 4 times and was not progressively higher with additional activity. Logistic regression estimating the odds of low BMD generally echoed the linear regression results. Conclusions The association between physical activity volume and BMD is complex. Among women, exceeding guidelines by 2-4 times may be important for maximizing BMD at the proximal femur, whereas among men, exceeding guidelines by 4 times may be beneficial for lumbar and proximal femur BMD. C1 [Whitfield, Geoffrey P.; Gabriel, Kelley K. Pettee; Rahbar, Mohammad H.; Kohl, Harold W., III] Univ Texas Austin, Sch Publ Hlth, Div Epidemiol Human Genet & Environm Sci, Austin, TX 78712 USA. [Kohrt, Wendy M.] Univ Colorado, Div Geriatr Med, Aurora, CO USA. [Rahbar, Mohammad H.] Univ Texas Hlth Sci Ctr Houston, Ctr Clin & Translat Sci, Houston, TX 77030 USA. [Kohl, Harold W., III] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA. RP Whitfield, GP (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway,Mailstop F58, Atlanta, GA 30341 USA. EM xdh5@cdc.gov FU University of Texas School of Public Health, Cancer Education and Career Development Program-National Cancer Institute/National Institutes of Health [2 R25 CA57712] FX G. P. W. was supported by a predoctoral fellowship from the University of Texas School of Public Health, Cancer Education and Career Development Program-National Cancer Institute/National Institutes of Health Grant #2 R25 CA57712 and thanks his colleagues in the program for their feedback. NR 28 TC 1 Z9 1 U1 0 U2 15 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD FEB PY 2015 VL 47 IS 2 BP 326 EP 334 DI 10.1249/MSS.0000000000000400 PG 9 WC Sport Sciences SC Sport Sciences GA AZ3AS UT WOS:000348100800014 PM 24870584 ER PT J AU Themann, CL Byrne, DC Davis, RR Morata, TC Murphy, WJ Stephenson, MR AF Themann, Christa L. Byrne, David C. Davis, Rickie R. Morata, Thais C. Murphy, William J. Stephenson, Mark R. TI Early prognosis of noise-induced hearing loss: prioritising prevention over prediction SO OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Editorial Material ID THRESHOLD SHIFT; GLOBAL BURDEN; TEMPORARY; SUSCEPTIBILITY; INJURY; DAMAGE C1 [Themann, Christa L.; Byrne, David C.; Davis, Rickie R.; Morata, Thais C.; Murphy, William J.; Stephenson, Mark R.] NIOSH, Div Appl Res & Technol, Cincinnati, OH 45226 USA. RP Themann, CL (reprint author), NIOSH, Div Appl Res & Technol, 1090 Tusculum Ave,MS C-27, Cincinnati, OH 45226 USA. EM CLT6@cdc.gov FU Intramural CDC HHS [CC999999] NR 12 TC 0 Z9 0 U1 1 U2 6 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1351-0711 EI 1470-7926 J9 OCCUP ENVIRON MED JI Occup. Environ. Med. PD FEB PY 2015 VL 72 IS 2 BP 83 EP 84 DI 10.1136/oemed-2014-102200 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY7YZ UT WOS:000347772900002 PM 25391832 ER PT J AU Bao, SS Kapellusch, JM Garg, A Silverstein, BA Harris-Adamson, C Burt, SE Dale, AM Evanoff, BA Gerr, FE Hegmann, KT Merlino, LA Thiese, MS Rempel, DM AF Bao, Stephen S. Kapellusch, Jay M. Garg, Arun Silverstein, Barbara A. Harris-Adamson, Carisa Burt, Susan E. Dale, Ann Marie Evanoff, Bradley A. Gerr, Frederic E. Hegmann, Kurt T. Merlino, Linda A. Thiese, Matthew S. Rempel, David M. TI Developing a pooled job physical exposure data set from multiple independent studies: an example of a consortium study of carpal tunnel syndrome SO OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID UPPER EXTREMITY DISORDERS; MUSCULOSKELETAL DISORDERS; RISK-FACTORS; PROSPECTIVE COHORT; STRAIN INDEX; WORK; WORKPLACE; POSTURE; HAND AB Background Six research groups independently conducted prospective studies of carpal tunnel syndrome (CTS) incidence in 54 US workplaces in 10 US States. Physical exposure variables were collected by all research groups at the individual worker level. Data from these research groups were pooled to increase the exposure spectrum and statistical power. Objective This paper provides a detailed description of the characteristics of the pooled physical exposure variables and the source data information from the individual research studies. Methods Physical exposure data were inspected and prepared by each of the individual research studies according to detailed instructions provided by an exposure subcommittee of the research consortium. Descriptive analyses were performed on the pooled physical exposure data set. Correlation analyses were performed among exposure variables estimating similar exposure aspects. Results At baseline, there were a total of 3010 participants in the pooled physical exposure data set. Overall, the pooled data meaningfully increased the spectra of most exposure variables. The increased spectra were due to the wider range in exposure data of different jobs provided by the research studies. The correlations between variables estimating similar exposure aspects showed different patterns among data provided by the research studies. Conclusions The increased spectra of the physical exposure variables among the data pooled likely improved the possibility of detecting potential associations between these physical exposure variables and CTS incidence. It is also recognised that methods need to be developed for general use by all researchers for standardisation of physical exposure variable definition, data collection, processing and reduction. C1 [Bao, Stephen S.; Silverstein, Barbara A.] Washington State Dept Labor & Ind, Safety & Hlth Assessment & Res Prevent SHARP Prog, Olympia, WA 98504 USA. [Kapellusch, Jay M.] Univ Wisconsin, Dept Occupat Sci & Technol, Milwaukee, WI 53201 USA. [Garg, Arun] Univ Wisconsin, Ctr Ergon, Milwaukee, WI 53201 USA. [Harris-Adamson, Carisa] Samuel Merritt Univ, Dept Phys Therapy, Oakland, CA USA. [Burt, Susan E.] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH 45226 USA. [Dale, Ann Marie; Evanoff, Bradley A.] Washington Univ Sch Med, Dept Med, St Louis, MO USA. [Gerr, Frederic E.; Merlino, Linda A.] Univ Iowa, Coll Publ Hlth, Dept Occupat & Environm Hlth, Iowa City, IA USA. [Hegmann, Kurt T.; Thiese, Matthew S.] Univ Utah, RMCOEH, Salt Lake City, UT USA. [Rempel, David M.] Univ Calif San Francisco, Div Occupat & Environm Med, San Francisco, CA 94143 USA. RP Bao, SS (reprint author), Washington State Dept Labor & Ind, Safety & Hlth Assessment & Res Prevent SHARP Prog, Olympia, WA 98504 USA. EM baos235@lni.wa.gov OI Evanoff, Bradley A./0000-0003-0085-333X FU National Institute for Occupational Safety and Health (NIOSH/CDC) [5R01OH009712]; Washington State Department of Labour and Industries, Olympia, Washington, USA FX This study was funded, in part, by a grant from the National Institute for Occupational Safety and Health (NIOSH/CDC) 5R01OH009712, and Washington State Department of Labour and Industries, Olympia, Washington, USA. NR 24 TC 4 Z9 4 U1 1 U2 11 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1351-0711 EI 1470-7926 J9 OCCUP ENVIRON MED JI Occup. Environ. Med. PD FEB PY 2015 VL 72 IS 2 BP 130 EP 137 DI 10.1136/oemed-2014-102396 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY7YZ UT WOS:000347772900009 PM 25504866 ER PT J AU Snyder, GL Vanover, KE Zhu, HW Miller, DB O'Callaghan, JP Tomesch, J Li, P Zhang, Q Krishnan, V Hendrick, JP Nestler, EJ Davis, RE Wennogle, LP Mates, S AF Snyder, Gretchen L. Vanover, Kimberly E. Zhu, Hongwen Miller, Diane B. O'Callaghan, James P. Tomesch, John Li, Peng Zhang, Qiang Krishnan, Vaishnav Hendrick, Joseph P. Nestler, Eric J. Davis, Robert E. Wennogle, Lawrence P. Mates, Sharon TI Functional profile of a novel modulator of serotonin, dopamine, and glutamate neurotransmission SO PSYCHOPHARMACOLOGY LA English DT Article DE Schizophrenia; Dopamine D-2 receptor; NMDA receptors; Serotonin5-HT2A receptor; Social defeat; Nucleus accumbens; Microdialysis; Mesocortical; Nigrostriatal; Serotonin transporter ID ATYPICAL ANTIPSYCHOTIC-DRUGS; MEDIAL PREFRONTAL CORTEX; D-ASPARTATE RECEPTORS; CHRONIC-SCHIZOPHRENIA; 5-HT2B RECEPTORS; PARTIAL AGONIST; ANIMAL-MODELS; HIGH-AFFINITY; IN-VIVO; HALOPERIDOL AB Schizophrenia remains among the most prevalent neuropsychiatric disorders, and current treatment options are accompanied by unwanted side effects. New treatments that better address core features of the disease with minimal side effects are needed. As a new therapeutic approach, 1-(4-fluoro-phenyl)-4-((6bR, 10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-butan-1-one (ITI-007) is currently in human clinical trials for the treatment of schizophrenia. Here, we characterize the preclinical functional activity of ITI-007. ITI-007 is a potent 5-HT2A receptor ligand (K (i) = 0.5 nM) with strong affinity for dopamine (DA) D-2 receptors (K (i) = 32 nM) and the serotonin transporter (SERT) (K (i) = 62 nM) but negligible binding to receptors (e.g., H-1 histaminergic, 5-HT2C, and muscarinic) associated with cognitive and metabolic side effects of antipsychotic drugs. In vivo it is a 5-HT2A antagonist, blocking (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI)-induced headtwitch in mice with an inhibitory dose 50 (ID50) = 0.09 mg/kg, per oral (p.o.), and has dual properties at D-2 receptors, acting as a postsynaptic D-2 receptor antagonist to block D-amphetamine hydrochloride (D-AMPH) hyperlocomotion (ID50 = 0.95 mg/kg, p.o.), yet acting as a partial agonist at presynaptic striatal D2 receptors in assays measuring striatal DA neurotransmission. Further, in microdialysis studies, this compound significantly and preferentially enhances mesocortical DA release. At doses relevant for antipsychotic activity in rodents, ITI-007 has no demonstrable cataleptogenic activity. ITI-007 indirectly modulates glutamatergic neurotransmission by increasing phosphorylation of GluN2B-type N-methyl-d-aspartate (NMDA) receptors and preferentially increases phosphorylation of glycogen synthase kinase 3 beta (GSK-3 beta) in mesolimbic/mesocortical dopamine systems. The combination of in vitro and in vivo activities of this compound support its development for the treatment of schizophrenia and other psychiatric and neurologic disorders. C1 [Snyder, Gretchen L.; Vanover, Kimberly E.; Zhu, Hongwen; Tomesch, John; Li, Peng; Zhang, Qiang; Hendrick, Joseph P.; Wennogle, Lawrence P.; Mates, Sharon] Intracellular Therapies Inc, New York, NY 10032 USA. [Miller, Diane B.; O'Callaghan, James P.] NIOSH, Ctr Dis Control & Prevent, CDC, Morgantown, WV 26505 USA. [Krishnan, Vaishnav; Nestler, Eric J.] Mt Sinai Sch Med, New York, NY 10028 USA. [Davis, Robert E.] 3D Pharmaceut Partners, San Diego, CA 92130 USA. RP Snyder, GL (reprint author), Intracellular Therapies Inc, 3960 Broadway, New York, NY 10032 USA. EM gsnyder@intracellulartherapies.com FU NIH [R43 MH067488-01]; US Army Medical Research and Materiel Command NETRP Program [DAMD 17-03-2-0019, W81XWH-05-1-0400, W81XWH-06-C-0013] FX This work was supported, in part, by funding from the NIH (R43 MH067488-01 to Intra-Cellular Therapies, Inc.) and the US Army Medical Research and Materiel Command NETRP Program (DAMD 17-03-2-0019, W81XWH-05-1-0400, and W81XWH-06-C-0013 to Intra-Cellular Therapies, Inc.). NR 66 TC 11 Z9 11 U1 0 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0033-3158 EI 1432-2072 J9 PSYCHOPHARMACOLOGY JI Psychopharmacology PD FEB PY 2015 VL 232 IS 3 BP 605 EP 621 DI 10.1007/s00213-014-3704-1 PG 17 WC Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA AZ6CU UT WOS:000348307000012 PM 25120104 ER PT J AU Felix, SE Bailey, CM Zahran, HS AF Felix, Suad El Burai Bailey, Cathy M. Zahran, Hatice S. TI Asthma prevalence among Hispanic adults in Puerto Rico and Hispanic adults of Puerto Rican descent in the United States - results from two national surveys SO JOURNAL OF ASTHMA LA English DT Article DE Adults; asthma; asthma prevalence; hispanic; non-Hispanic; Puerto Rican; risk factors AB Objective: To assess whether asthma prevalence differs between Hispanic adults living in Puerto Rico and Hispanic adults of Puerto Rican descent living in the United States. Methods: We used 2008-2010 Behavioral Risk Factor Surveillance System data, administered in Puerto Rico for Hispanic adults living in Puerto Rico (Hispanics in Puerto Rico), and 2008-2010 National Health Interview Survey data for Hispanic adults of Puerto Rican descent living in the United States (Puerto Rican Americans). We used 95% confidence intervals (CIs) to compare asthma prevalence between corresponding subgroups; non-overlapping CIs indicate statistical significance. Chi-square test and multivariate logistic regression were used to assess the association between current asthma status and socio-demographic factors and health risk behaviors within each Puerto Rican population. Results: Current asthma prevalence among Hispanics in Puerto Rico (7.0% [6.4%-7.7%]) was significantly lower than the prevalence among Puerto Rican Americans (15.6% [13.0%-18.1%]). The prevalence among almost all socio-demographic and health risk subgroups of Hispanics in Puerto Rico was significantly lower than the prevalence among the corresponding subgroups of Puerto Rican Americans. Adjusting for potential confounders did not alter the results. Asthma prevalence was significantly associated with obesity among Puerto Rican Americans (adjusted prevalence ratios [aPR] = 1.5 [1.1-2.0]), and among Hispanics in Puerto Rico was associated with obesity (aPR = 1.6 [1.3-1.9]), smoking (aPR = 1.4 [1.1-1.9]) and being female (aPR = 1.9 [1.5-2.4]). Conclusion: Asthma was more prevalent among Puerto Rican Americans than Hispanics in Puerto Rico. Although the observed associations did not explain all variations in asthma prevalence between these two populations, they may lay the foundation for future research. C1 [Felix, Suad El Burai; Bailey, Cathy M.; Zahran, Hatice S.] Ctr Dis Control & Prevent, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Felix, SE (reprint author), Vet Hlth Adm, Perry Point VA Med Ctr, Cooperat Studies Program Coordinat Ctr, Dept Vet Affairs, Bldg 4R,Boilerhouse Rd,POB 1010, Perry Point, MD 21902 USA. EM suad.elburaifelix@va.gov FU CDC through the Oak Ridge Institute for Science and Education (ORISE) fellowship program FX This project was undertaken while S. E. B. F. was under contract with CDC through the Oak Ridge Institute for Science and Education (ORISE) fellowship program. Rose Rudd contributed in providing comments and reviewing the draft manuscript. Dana Flanders contributed in providing comments and reviewing the draft manuscript. NR 18 TC 0 Z9 0 U1 0 U2 7 PU INFORMA HEALTHCARE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 0277-0903 EI 1532-4303 J9 J ASTHMA JI J. Asthma PD FEB PY 2015 VL 52 IS 1 BP 3 EP 9 DI 10.3109/02770903.2014.950427 PG 7 WC Allergy; Respiratory System SC Allergy; Respiratory System GA AY6RW UT WOS:000347694200002 ER PT J AU White, GE Mazurek, JM Storey, E AF White, Gretchen E. Mazurek, Jacek M. Storey, Eileen TI Employed adults with asthma who have frequent workplace exposures SO JOURNAL OF ASTHMA LA English DT Article DE Asthma; dust; fumes; gas; NHIS; occupational exposure; secondhand smoke ID ENVIRONMENTAL TOBACCO-SMOKE; YOUNG-ADULTS; WORK; HEALTH; PREVALENCE; OCCUPATION; AGENTS; HIRE AB Objective: The recent increase in asthma prevalence is thought to be partially due to environmental changes such as changes in air pollution and occupational exposures. Nationally representative information on workplace exposures among US adults with asthma is limited. Methods: We examined 2010 National Health Interview Survey data to determine the proportion of employed adults with asthma who had frequent workplace exposures. Results: Among adults with current asthma, 19.6% frequently worked outdoors, 17.5% were frequently exposed to workplace secondhand smoke and 28.1% were frequently exposed to workplace vapors, gas, dust or fumes. Adults ever told by a health professional that asthma is probably work-related, when compared to adults who were not, had increased odds of frequent work outdoors [prevalence odds ratio (POR) = 2.76], frequent workplace exposure to secondhand smoke (POR = 3.08) and frequent workplace exposure to vapors, gas, dust or fumes (POR = 3.56). Conclusions: To our knowledge, this is the first population-based study in USA that estimates the proportion of working adults with asthma that have frequent workplace exposures. Increasing the understanding of workplace exposures among adults with asthma will help enable prevention of asthma through workplace exposure reduction or avoidance. Future studies should further examine industries and occupations of individuals with asthma and frequent workplace exposures. C1 [White, Gretchen E.; Mazurek, Jacek M.; Storey, Eileen] NIOSH, Div Resp Dis Studies, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. RP Mazurek, JM (reprint author), NIOSH, Div Resp Dis Studies, Ctr Dis Control & Prevent, 1095 Willowdale Rd,MS HG-900-2, Morgantown, WV 26505 USA. EM JMazurek1@cdc.gov FU Intramural CDC HHS [CC999999] NR 38 TC 2 Z9 2 U1 0 U2 2 PU INFORMA HEALTHCARE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 0277-0903 EI 1532-4303 J9 J ASTHMA JI J. Asthma PD FEB PY 2015 VL 52 IS 1 BP 46 EP 51 DI 10.3109/02770903.2014.944984 PG 6 WC Allergy; Respiratory System SC Allergy; Respiratory System GA AY6RW UT WOS:000347694200008 PM 25029228 ER PT J AU Rubenstein, E Wiggins, LD Lee, LC AF Rubenstein, Eric Wiggins, Lisa D. Lee, Li-Ching TI A Review of the Differences in Developmental, Psychiatric, and Medical Endophenotypes Between Males and Females with Autism Spectrum Disorder SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES LA English DT Article DE Autism spectrum disorder; Sex differences; Endophenotypes; Co-occurring conditions ID JUVENILE MYOCLONIC EPILEPSY; SELF-INJURIOUS BEHAVIORS; SEX-DIFFERENCES; RISK-FACTORS; INTELLECTUAL DISABILITY; GENDER-DIFFERENCES; CHALLENGING BEHAVIORS; LANGUAGE-SKILLS; YOUNG-CHILDREN; POPULATION AB Autism spectrum disorder (ASD) is over four times more prevalent in males compared to females. Increased understanding of sex differences in ASD endophenotypes could add insight into possible etiologies and the assessment and management of the disorder. Consequently, the purpose of this review is to describe current literature regarding sex differences in the developmental, psychiatric, and medical endophenotypes of ASD in order to illustrate current knowledge and areas in need of further research. Our review found that repetitive behaviors and restricted interests are more common in males than females with ASD. Intellectual disability is more common in females than males with ASD. Attention to detail may be more common in males than females with ASD and epilepsy may be more common in females than males with ASD, although limited research in these areas prevent definitive conclusions from being drawn. There does not appear to be a sex difference in other developmental, psychiatric, and medical symptoms associated with ASD, or the research was contradictory or too sparse to establish a sex difference. Our review is unique in that it offers detailed discussion of sex differences in three major endophenotypes of ASD. Further research is needed to better understand why sex differences exist in certain ASD traits and to evaluate whether phenotypic sex differences are related to different pathways of development, assessment, and treatment of the disorder. C1 [Rubenstein, Eric; Lee, Li-Ching] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA. [Wiggins, Lisa D.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Lee, LC (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, 615 N Wolfe St,Room E6032, Baltimore, MD 21205 USA. EM llee38@jhu.edu OI Rubenstein, Eric/0000-0002-9146-4497 FU Intramural CDC HHS [CC999999] NR 104 TC 9 Z9 9 U1 9 U2 37 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1056-263X EI 1573-3580 J9 J DEV PHYS DISABIL JI J. Dev. Phys. Disabil. PD FEB PY 2015 VL 27 IS 1 BP 119 EP 139 DI 10.1007/s10882-014-9397-x PG 21 WC Rehabilitation SC Rehabilitation GA AZ6QZ UT WOS:000348345000009 PM 26146472 ER PT J AU Ouyang, L Bolen, J Valdez, R Joseph, D Baum, MA Thibadeau, J AF Ouyang, Lijing Bolen, Julie Valdez, Rodolfo Joseph, David Baum, Michelle A. Thibadeau, Judy TI Characteristics and Survival of Patients with End Stage Renal Disease and Spina Bifida in the United States Renal Data System SO JOURNAL OF UROLOGY LA English DT Article DE kidney failure; chronic; spinal dysraphism; urinary tract infections; transplantation; dialysis ID SINGLE-CENTER EXPERIENCE; PERITONEAL-DIALYSIS; NEUROGENIC BLADDER; FOLLOW-UP; VENTRICULOPERITONEAL SHUNT; TRANSPLANTATION; CHILDREN; DYSFUNCTION; MANAGEMENT AB Purpose: We describe the characteristics, treatments and survival of patients with spina bifida in whom end stage renal disease developed from 2004 through 2008 in the United States Renal Data System. Materials and Methods: We used ICD-9-CM code 741.* to identify individuals with spina bifida using hospital inpatient data from 1977 to 2010, and physician and facility claims from 2004 to 2008. We constructed a 5: 1 comparison group of patients with end stage renal disease without spina bifida matched by age at first end stage renal disease service, gender and race/ethnicity. We assessed the risk of mortality and of renal transplantation while on dialysis using multivariate cause specific proportional hazards survival analysis. We also compared survival after the first renal transplant from the first end stage renal disease service to August 2011. Results: We identified 439 patients with end stage renal disease and spina bifida in whom end stage renal disease developed at an average younger age than in patients without spina bifida (41 vs 62 years, p < 0.001) and in whom urological issues were the most common primary cause of end stage renal disease. Compared to patients with end stage renal disease without spina bifida those who had spina bifida showed a similar mortality hazard on dialysis and after transplantation. However, patients with end stage renal disease without spina bifida were more likely to undergo renal transplantation than patients with spina bifida (HR 1.51, 95% CI 1.13-2.03). Hospitalizations related to urinary tract infections were positively associated with the risk of death on dialysis in patients with end stage renal disease and spina bifida (HR 1.42, 95% CI 1.33-1.53). Conclusions: Spina bifida was not associated with increased mortality in patients with end stage renal disease on dialysis or after renal transplantation. Proper urological and bladder management is imperative in patients with spina bifida, particularly in adults. C1 [Ouyang, Lijing; Bolen, Julie; Valdez, Rodolfo; Thibadeau, Judy] Ctr Dis Control & Prevent, Rare Disorders & Hlth Outcomes Team, Natl Ctr Birth Defects & Dev Disabil, Bethesda, MD USA. [Joseph, David] Univ Alabama Birmingham, Sch Med, Dept Urol, Birmingham, AL USA. [Baum, Michelle A.] Harvard Univ, Sch Med, Div Nephrol, Boston Childrens Hosp, Boston, MA USA. RP Ouyang, L (reprint author), 1600 Clifton Rd Northeast,MS E-88, Atlanta, GA 30329 USA. EM louyang@cdc.gov FU Intramural CDC HHS [CC999999] NR 28 TC 4 Z9 4 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 EI 1527-3792 J9 J UROLOGY JI J. Urol. PD FEB PY 2015 VL 193 IS 2 BP 558 EP 564 DI 10.1016/j.juro.2014.08.092 PG 7 WC Urology & Nephrology SC Urology & Nephrology GA AY6YZ UT WOS:000347709800046 PM 25167993 ER PT J AU Saraiya, M Senkomago, V AF Saraiya, Mona Senkomago, Virginia TI A door-to-door approach to cervical cancer screening SO LANCET GLOBAL HEALTH LA English DT Editorial Material ID METAANALYSIS; SAMPLES C1 [Saraiya, Mona; Senkomago, Virginia] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA 30329 USA. RP Saraiya, M (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA 30329 USA. EM msaraiya@cdc.gov FU Intramural CDC HHS [CC999999] NR 13 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 2214-109X J9 LANCET GLOB HEALTH JI Lancet Glob. Health PD FEB PY 2015 VL 3 IS 2 BP E63 EP E64 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ4NR UT WOS:000348199700002 PM 25617192 ER PT J AU Razzaghi, H Marcinkevage, J Peterson, C AF Razzaghi, Hilda Marcinkevage, Jessica Peterson, Cora TI Prevalence of undiagnosed diabetes among non-pregnant women of reproductive age in the United States, 1999-2010 SO PRIMARY CARE DIABETES LA English DT Article DE Diabetes mellitus/diagnosis; Diabetes mellitus/epidemiology; Pregnancy complications ID PREGNANCY; OUTCOMES; FETAL AB Undiagnosed diabetes has particularly harmful consequences among women of reproductive age. We assessed the prevalence of undiagnosed diabetes among non-pregnant women of reproductive age. In our data 30 women had A1C >= 6.5 and 28 had FPG >= 126 mg/dl values suggesting approximately 300,000 women of reproductive age nationwide may have undiagnosed diabetes. (c) 2013 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved. C1 [Razzaghi, Hilda; Marcinkevage, Jessica; Peterson, Cora] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Razzaghi, Hilda] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Marcinkevage, Jessica] Emory Univ, Laney Grad Sch, Nutr & Hlth Sci Program, Atlanta, GA 30322 USA. RP Razzaghi, H (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd NE,MS E-86, Atlanta, GA 30333 USA. EM hir2@cdc.gov OI Peterson, Cora/0000-0001-7955-0977 FU Intramural CDC HHS [CC999999]; NIDDK NIH HHS [T32 DK007734] NR 12 TC 1 Z9 1 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1751-9918 EI 1878-0210 J9 PRIM CARE DIABETES JI Prim. Care Diabetes PD FEB PY 2015 VL 9 IS 1 BP 71 EP 73 DI 10.1016/j.pcd.2013.10.004 PG 3 WC Endocrinology & Metabolism; Primary Health Care SC Endocrinology & Metabolism; General & Internal Medicine GA AZ5MR UT WOS:000348265500011 PM 24216319 ER PT J AU Yorio, PL Willmer, DR Moore, SM AF Yorio, Patrick L. Willmer, Dana R. Moore, Susan M. TI Health and safety management systems through a multilevel and strategic management perspective: Theoretical and empirical considerations SO SAFETY SCIENCE LA English DT Review DE Multilevel theory and methods; Strategic management; Health and safety management systems; Safety climate; Safety culture ID PERFORMANCE WORK SYSTEMS; LEADER-MEMBER EXCHANGE; FIRM PERFORMANCE; OCCUPATIONAL-HEALTH; HUMAN-RESOURCES; TRANSFORMATIONAL LEADERSHIP; ORGANIZATIONAL VALUES; MEASUREMENT ERROR; CULTURE; CLIMATE AB Multilevel and strategic management theory and research methods are presented and applied to current issues in occupational health and safety (H&S), the primary goal being to better understand health and safety management systems (HSMS) from a theoretical and empirical perspective. Through these perspectives, a strategic HSMS may be understood as a construct that exists objectively at the strategic level of the organization-its objective content often distinct from the implemented practices and procedures within a workgroup and from worker perceptions and interpretations of its content. These nuances highlight the types of biases that can arise when choosing a level of measurement to assess the HSMS and techniques that can be used to minimize measurement error and increase the validity of inferences made. These nuances also illuminate the contingencies important for the success of a strategic organizational HSMS. The contingencies are discussed from a theoretical perspective and presented in a conceptual HSMS model. Published by Elsevier Ltd. C1 [Yorio, Patrick L.; Willmer, Dana R.; Moore, Susan M.] NIOSH, US CDC, Off Mine Safety & Hlth Res, Pittsburgh, PA 15236 USA. RP Yorio, PL (reprint author), NIOSH, CDC, Off Mine Safety & Hlth Res, 626 Cochrans Mill Rd,POB 18070, Pittsburgh, PA 15236 USA. EM pyorio@cdc.gov NR 60 TC 4 Z9 6 U1 4 U2 31 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0925-7535 EI 1879-1042 J9 SAFETY SCI JI Saf. Sci. PD FEB PY 2015 VL 72 BP 221 EP 228 DI 10.1016/j.ssci.2014.09.011 PG 8 WC Engineering, Industrial; Operations Research & Management Science SC Engineering; Operations Research & Management Science GA AZ1QC UT WOS:000348012100023 ER PT J AU Smith, DK Herbst, JH Rose, CE AF Smith, Dawn K. Herbst, Jeffrey H. Rose, Charles E. TI Estimating HIV Protective Effects of Method Adherence With Combinations of Preexposure Prophylaxis and Condom Use Among African American Men Who Have Sex With Men SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID NEW-YORK-CITY; UNITED-STATES; ANTIRETROVIRAL PROPHYLAXIS; RISK BEHAVIOR; PERSPECTIVE; INFECTIONS; SAMPLE; WOMEN; MSM AB Background: Prevention of sexually acquired HIV infection now includes both consistent condom use and daily use of oral antiretroviral preexposure prophylaxis (PrEP). Persons at substantial HIV risk can now use one or both prevention methods, but a combined HIV protective effect has not been assessed. Methods: We use deterministic models to examine the impact of method adherence and rates of PrEP and male condom use on number of anticipated HIV infections. Analyses were based on hypothetical cohorts of 10,000 African American men who have sex with men (AAMSM), a population with the highest HIV incidence in the United States. Parameters used in the model (condom effectiveness, PrEP effectiveness, HIV incidence) were based on published findings. Results: Among AAMSM who never use PrEP, an estimated 323 annual HIV infections would occur among those who always use condoms, 1007 among sometimes condom users, and 1094 among never condoms users. Among AAMSM who never (or inconsistently) use condoms, 295 (272) infections would occur among those who report at least 90% PrEP adherence and 744 (684) infection occur with less than 50% adherence. Among AAMSM who are consistently (or sometimes) taking PrEP, the highest protection is seen with consistent condom use, 87 (220) HIV infections and 92.0% (79.9%) prevention effectiveness. Discussion: Among AAMSM with inconsistent or never condom use, the addition of PrEP at either modest or high adherence can increase HIV protection. For consistent condom users, any PrEP use can increase HIV protection. These analyses provide an approach for rethinking HIV risk management by calculating combined HIV protective effects of using one or more effective prevention methods. C1 [Smith, Dawn K.; Herbst, Jeffrey H.; Rose, Charles E.] Ctr Dis Control & Prevent CDC, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. RP Smith, DK (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, 1600 Clifton Rd,Mail Stop E-45, Atlanta, GA 30333 USA. EM dsmith1@cdc.gov NR 33 TC 2 Z9 2 U1 1 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD FEB PY 2015 VL 42 IS 2 BP 88 EP 92 DI 10.1097/OLQ.0000000000000238 PG 5 WC Infectious Diseases SC Infectious Diseases GA AZ3PP UT WOS:000348139600007 PM 25585067 ER PT J AU Bardenheier, BH Imperatore, G Devlin, HM Kim, SY Cho, P Geiss, LS AF Bardenheier, Barbara H. Imperatore, Giuseppina Devlin, Heather M. Kim, Shin Y. Cho, Pyone Geiss, Linda S. TI Trends in Pre-Pregnancy Diabetes Among Deliveries in 19 US States, 2000-2010 SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID HOSPITAL DISCHARGE DATA; BLOOD-PRESSURE; UNITED-STATES; LONG-TERM; PREVALENCE; WOMEN; ADULTS; ADOLESCENTS; CHILDREN; MELLITUS AB Background: Trends in state-level prevalence of pre-pregnancy diabetes mellitus (PDM; i.e., type 1 or type 2 diabetes diagnosed before pregnancy) among delivery hospitalizations are needed to inform healthcare delivery planning and prevention programs. Purpose: To examine PDM trends overall, by age group, race/ethnicity, primary payer, and with comorbidities such as pre-eclampsia and pre-pregnancy hypertension, and to report changes in prevalence over 11 years. Methods: In 2014, State Inpatient Databases from the Agency for Healthcare Research and Quality were analyzed to identify deliveries with PDM and comorbidities using diagnosis-related group codes and ICD-9-CM codes. General linear regression with a log-link and binomial distribution was used to assess the annual change. Results: Between 2000 and 2010, PDM deliveries increased significantly in all age groups, all race/ethnicity groups, and in all states examined (p < 0.01). The age-standardized prevalence of PDM increased from 0.65 per 100 deliveries in 2000 to 0.89 per 100 deliveries in 2010, with a relative change of 37% (p < 0.01). Although PDM rates were highest in the South, some of the largest relative increases occurred in five Western states ( >= 69%). Non-Hispanic blacks had the highest PDM rates and the highest absolute increase (0.26 per 100 deliveries). From 2000 to 2010, the proportion of PDM deliveries with pre-pregnancy hypertension increased significantly (p < 0.01) from 7.4% to 14.1%. Conclusions: PDM deliveries are increasing overall and particularly among those with PDM who have hypertension. Effective diabetes prevention and control strategies for women of childbearing age may help protect their health and that of their newborns. Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine C1 [Bardenheier, Barbara H.; Imperatore, Giuseppina; Devlin, Heather M.; Cho, Pyone; Geiss, Linda S.] CDC, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Diabet Translat, Atlanta, GA 30341 USA. [Kim, Shin Y.] CDC, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, Atlanta, GA 30341 USA. RP Bardenheier, BH (reprint author), CDC, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Diabet Translat, 4770 Buford Highway NE,MS F-73, Atlanta, GA 30341 USA. EM bfb7@cdc.gov FU Intramural CDC HHS [CC999999] NR 27 TC 7 Z9 7 U1 0 U2 8 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD FEB PY 2015 VL 48 IS 2 BP 154 EP 161 DI 10.1016/j.amepre.2014.08.031 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA AZ2YY UT WOS:000348096300005 PM 25326417 ER PT J AU Guy, GP Machlin, SR Ekwueme, DU Yabroff, KR AF Guy, Gery P., Jr. Machlin, Steven R. Ekwueme, Donatus U. Yabroff, K. Robin TI Prevalence and Costs of Skin Cancer Treatment in the US, 2002-2006 and 2007-2011 SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID METAANALYSIS; MELANOMA AB Background: Skin cancer, the most common cancer in the U.S., is a major public health problem. The incidence of nonmelanoma and melanoma skin cancer is increasing; however, little is known about the economic burden of treatment. Purpose: To examine trends in the treated prevalence and treatment costs of nonmelanoma and melanoma skin cancers. Methods: This study used data on adults from the 2002-2011 Medical Expenditure Panel Survey full-year consolidated files and information from corresponding medical conditions and medical event files to estimate the treated prevalence and treatment cost of nonmelanoma skin cancer, melanoma skin cancer, and all other cancer sites. Analyses were conducted in January 2014. Results: The average annual number of adults treated for skin cancer increased from 3.4 million in 2002-2006 to 4.9 million in 2007-2011 (p<0.001). During this period, the average annual total cost for skin cancer increased from $3.6 billion to $8.1 billion (p=-0.001), representing an increase of 126.2%, while the average annual total cost for all other cancers increased by 25.1%. During 2007-2011, nearly 5 million adults were treated for skin cancer annually, with average treatment costs of $8.1 billion each year. Conclusions: These findings demonstrate that the health and economic burden of skin cancer treatment is substantial and increasing. Such findings highlight the importance of skin cancer prevention efforts, which may result in future savings to the healthcare system. Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine C1 [Guy, Gery P., Jr.; Ekwueme, Donatus U.] CDC, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Machlin, Steven R.] NCI, Ctr Financing Access & Cost Trends, Agcy Healthcare Res & Qual, Rockville, MD USA. [Yabroff, K. Robin] NCI, Div Canc Control & Populat Sci, Rockville, MD USA. RP Guy, GP (reprint author), CDC, Div Canc Prevent & Control, 4770 Buford Highway NE,MS F-76, Atlanta, GA 30341 USA. EM irm2@cdc.gov OI Yabroff, K. Robin/0000-0003-0644-5572 FU Social & Scientific Systems, Inc. FX We would like to thank Zhengyi Fang of Social & Scientific Systems, Inc. for programming support. NR 12 TC 56 Z9 57 U1 4 U2 15 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD FEB PY 2015 VL 48 IS 2 BP 183 EP 187 DI 10.1016/j.amepre.2014.08.036 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA AZ2YY UT WOS:000348096300010 PM 25442229 ER PT J AU Simeone, RM Devine, OJ Marcinkevage, JA Gilboa, SM Razzaghi, H Bardenheier, BH Sharma, AJ Honein, MA AF Simeone, Regina M. Devine, Owen J. Marcinkevage, Jessica A. Gilboa, Suzanne M. Razzaghi, Hilda Bardenheier, Barbara H. Sharma, Andrea J. Honein, Margaret A. TI Diabetes and Congenital Heart Defects A Systematic Review, Meta-Analysis, and Modeling Project SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID INDEPENDENT RISK-FACTOR; BIRTH-DEFECTS; PRECONCEPTION CARE; UNITED-STATES; CARDIOVASCULAR MALFORMATIONS; METROPOLITAN ATLANTA; US POPULATION; OBESE WOMEN; PREVALENCE; MELLITUS AB Context: Maternal pregestational diabetes (PGDM) is a risk factor for development of congenital heart defects (CHDs). Glycemic control before pregnancy reduces the risk of CHDs. A meta-analysis was used to estimate summary ORs and mathematical modeling was used to estimate population attributable fractions (PAFs) and the annual number of CHDs in the U.S. potentially preventable by establishing glycemic control before pregnancy. Evidence acquisition: A systematic search of the literature through December 2012 was conducted in 2012 and 2013. Case-control or cohort studies were included. Data were abstracted from 12 studies for a meta-analysis of all CHDs. Evidence synthesis: Summary estimates of the association between PGDM and CHDs and 95% credible intervals (95% CrIs) were developed using Bayesian random-effects meta-analyses for all CHDs and specific CHD subtypes. Posterior estimates of this association were combined with estimates of CHD prevalence to produce estimates of PAFs and annual prevented cases. Ninety-five percent uncertainty intervals (95% UIs) for estimates of the annual number of preventable cases were developed using Monte Carlo simulation. Analyses were conducted in 2013. The summary OR estimate for the association between PGDM and CHDs was 3.8 (95% CrI=3.0, 4.9). Approximately 2670 (95% UI=1795, 3795) cases of CHDs could potentially be prevented annually if all women in the U.S. with PGDM achieved glycemic control before pregnancy. Conclusions: Estimates from this analysis suggest that preconception care of women with PGDM could have a measureable impact by reducing the number of infants born with CHDs. Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine C1 [Simeone, Regina M.; Devine, Owen J.; Marcinkevage, Jessica A.; Gilboa, Suzanne M.; Razzaghi, Hilda; Honein, Margaret A.] CDC, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Bardenheier, Barbara H.; Sharma, Andrea J.] CDC, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Sharma, Andrea J.] US Publ Hlth Serv Commissioned Corps, Atlanta, GA USA. [Simeone, Regina M.; Marcinkevage, Jessica A.; Razzaghi, Hilda] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. RP Simeone, RM (reprint author), CDC, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd NE,Mail Stop E-86, Atlanta, GA 30333 USA. EM rsimeone@cdc.gov OI Sharma, Andrea/0000-0003-0385-0011 FU U.S. Department of Energy; CDC FX The authors gratefully acknowledge librarians, Christy Cechman, MLIS, of the American Public University System, and Gail Bang, MLIS, of the CDC Public Health Library and Information Center, who conducted the literature searches; Jaynia Anderson, MPH, a graduate student from Emory University's Rollins School of Public Health, who assisted with the collection and maintenance of the manuscripts; and Amy Cordero, MPA, who developed the original search strategy for this project. This research (J.A.M., H.R., R.M.S.) was supported in part by an appointment to the Research Participation Program at CDC administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and CDC. NR 65 TC 9 Z9 9 U1 0 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD FEB PY 2015 VL 48 IS 2 BP 195 EP 204 DI 10.1016/j.amepre.2014.09.002 PG 10 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA AZ2YY UT WOS:000348096300012 PM 25326416 ER PT J AU Haegerich, TM Sugerman, DE Annest, JL Klevens, J Baldwin, GT AF Haegerich, Tamara M. Sugerman, David E. Annest, Joseph L. Klevens, Joanne Baldwin, Grant T. TI Improving Injury Prevention Through Health Information Technology SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID INTIMATE PARTNER VIOLENCE; DECISION-SUPPORT-SYSTEMS; FORCE RECOMMENDATION STATEMENT; CHRONIC NONCANCER PAIN; RANDOMIZED-TRIAL; OLDER-ADULTS; PRIMARY-CARE; EMERGENCY-DEPARTMENT; DOMESTIC VIOLENCE; FALLS AB Health information technology is an emerging area of focus in clinical medicine with the potential to improve injury and violence prevention practice. With injuries being the leading cause of death for Americans aged 1-44 years, greater implementation of evidence-based preventive services, referral to community resources, and real-time surveillance of emerging threats is needed. Through a review of the literature and capturing of current practice in the field, this paper showcases how health information technology applied to injury and violence prevention can lead to strengthened clinical preventive services, more rigorous measurement of clinical outcomes, and improved injury surveillance, potentially resulting in health improvement. Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine C1 [Haegerich, Tamara M.; Sugerman, David E.; Annest, Joseph L.; Klevens, Joanne; Baldwin, Grant T.] CDC, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA. RP Haegerich, TM (reprint author), CDC, Natl Ctr Injury Prevent & Control, Div Unintent Injury Prevent, 4770 Buford Hwy NW MS F62, Atlanta, GA 30341 USA. EM thaegerich@cdc.gov OI Klevens, Joanne/0000-0003-4151-8853 FU Intramural CDC HHS [CC999999] NR 63 TC 2 Z9 3 U1 2 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD FEB PY 2015 VL 48 IS 2 BP 219 EP 228 DI 10.1016/j.amepre.2014.08.018 PG 10 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA AZ2YY UT WOS:000348096300016 PM 25441230 ER PT J AU Payne, DC Parashar, UD Lopman, BA AF Payne, Daniel C. Parashar, Umesh D. Lopman, Benjamin A. TI Developments in understanding acquired immunity and innate susceptibility to norovirus and rotavirus gastroenteritis in children SO CURRENT OPINION IN PEDIATRICS LA English DT Review DE acquired; FUT2; histo-blood group antigen; immunity; innate; norovirus; rotavirus; vaccine ID BLOOD GROUP ANTIGEN; UNITED-STATES; DIARRHEAL DISEASE; VIRAL LOAD; INFECTIONS; COMMUNITY; OUTBREAKS; GENOTYPE; VACCINE AB Purpose of review We discuss recent advances in the understanding of acquired immunity and susceptibility to the two major pediatric enteric viral pathogens, norovirus and rotavirus. Recent findings The prominent decline in severe rotavirus gastroenteritis in areas with mature rotavirus vaccination programmes has correspondingly unmasked the significant burden of disease associated with norovirus gastroenteritis among children. As epidemiologists and vaccinologists set their sights on this next vaccine target, we provide an update on norovirus vaccine development. In addition to these developments regarding acquired immunity, refinements to our understanding of innate susceptibility to norovirus has advanced. Significant recent advances now describe similar immunologic mechanisms in understanding susceptibility for both norovirus and rotavirus, involving histo-blood group antigenic associations, which may also prove to be genotype specific. Summary This information can potentially be used to tailor both applied and developmental efforts to public health interventions against these important pediatric enteric viral pathogens. C1 [Payne, Daniel C.; Parashar, Umesh D.; Lopman, Benjamin A.] US Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Atlanta, GA USA. RP Payne, DC (reprint author), CDC, 1600 Clifton Rd,NE,MS-A34, Atlanta, GA 30333 USA. EM dvp6@cdc.gov FU Intramural CDC HHS [CC999999] NR 24 TC 3 Z9 3 U1 0 U2 12 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1040-8703 EI 1531-698X J9 CURR OPIN PEDIATR JI CURR. OPIN. PEDIATR. PD FEB PY 2015 VL 27 IS 1 BP 105 EP 109 DI 10.1097/MOP.0000000000000166 PG 5 WC Pediatrics SC Pediatrics GA AY8AA UT WOS:000347775600015 PM 25490691 ER PT J AU Fernandez, ME Savas, LS Wilson, KM Byrd, TL Atkinson, J Torres-Vigil, I Vernon, SW AF Fernandez, Maria E. Savas, Lara S. Wilson, Katherine M. Byrd, Theresa L. Atkinson, John Torres-Vigil, Isabel Vernon, Sally W. TI Colorectal Cancer Screening Among Latinos in Three Communities on the Texas-Mexico Border SO HEALTH EDUCATION & BEHAVIOR LA English DT Article DE cancer screening; colorectal cancer; Hispanic Americans ID UNITED-STATES; AFRICAN-AMERICANS; FACTORIAL VALIDITY; SOCIETY GUIDELINES; PREDICTORS; HISPANICS; PARTICIPATION; STAGE; ASSOCIATION; VALIDATION AB Objective. To assess colorectal cancer screening (CRCS) prevalence and psychosocial correlates of CRCS among Latinos in South Texas. Method. Using multivariable analyses, we examined the association of perceived susceptibility, self-efficacy, pros and cons, subjective norms, knowledge and fatalism on CRCS among 544 Latinos (50 years and older). Results. In this socioeconomically disadvantaged population, 40% had never heard of any CRCS test, only 34% reported ever completing any type of CRCS, and only 25% were adherent to CRCS guidelines. Insurance status, gender, perceived cons, CRCS self-efficacy, and CRCS norms were significantly associated with CRCS. Conclusion. CRCS interventions in this population should focus on improving access, increasing self-efficacy and perceived norms, and decreasing negative perceptions of CRCS. C1 [Fernandez, Maria E.; Savas, Lara S.; Atkinson, John; Vernon, Sally W.] Univ Texas Sch Publ Hlth, Houston, TX 77030 USA. [Wilson, Katherine M.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Byrd, Theresa L.] Texas Tech Univ, Hlth Sci Ctr, Texas Tech Paul L Foster Sch Med, Dept Family & Community Med, El Paso, TX USA. [Torres-Vigil, Isabel] Univ Texas MD Anderson Canc Ctr, Dept Palliat Care & Rehabil Med, Houston, TX 77030 USA. [Torres-Vigil, Isabel] Univ Houston Grad Coll Social Work, Dorothy I Height Ctr Hlth Equ & Evaluat Res, Houston, TX USA. RP Fernandez, ME (reprint author), Univ Texas Sch Publ Hlth, Div Hlth Promot & Behav Sci, 7000 Fannin St,Suite 2558, Houston, TX 77030 USA. EM Maria.E.Fernandez@uth.tmc.edu FU NCI NIH HHS [5K01CA15178504, K01 CA151785, 2 R25 CA57712, R25 CA057712] NR 67 TC 4 Z9 4 U1 1 U2 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1090-1981 EI 1552-6127 J9 HEALTH EDUC BEHAV JI Health Educ. Behav. PD FEB PY 2015 VL 42 IS 1 BP 16 EP 25 DI 10.1177/1090198114529592 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ1DZ UT WOS:000347981700003 PM 24786793 ER PT J AU Hirve, S Krishnan, A Dawood, FS Lele, P Saha, S Rai, S Gupta, V Lafond, KE Juvekar, S Potdar, V Broor, S Lal, RB Chadha, M AF Hirve, Siddhivinayak Krishnan, Anand Dawood, Fatimah S. Lele, Pallavi Saha, Siddhartha Rai, Sanjay Gupta, Vivek Lafond, Kathryn E. Juvekar, Sanjay Potdar, Varsha Broor, Shobha Lal, Renu B. Chadha, Mandeep TI Incidence of influenza-associated hospitalization in rural communities in western and northern India, 2010-2012: A multi-site population-based study SO JOURNAL OF INFECTION LA English DT Article DE Influenza; Hospitalization; Health utilization survey; Burden; Seasonality ID RESPIRATORY-INFECTIONS; CASE DEFINITIONS; SURVEILLANCE; BURDEN AB Background: The global burden of influenza is increasingly recognized, but data from India remain sparse. We conducted a multi-site population-based surveillance study to estimate and compare rates of influenza-associated hospitalization at two rural Indian health and demographic surveillance system (HDSS) sites at Ballabgarh and Vadu during 2010-2012. Methods: Prospective facility-based surveillance for all hospitalizations (excluding those for trauma, elective surgery and obstetric, ophthalmic or psychiatric reasons) was conducted at 72 health facilities. After collection of clinical details, patients had nasopharyngeal swabs taken and tested by reverse transcription polymerase chain reaction for influenza viruses. Annual healthcare utilization surveys (HUS) were conducted in HDSS households to identify proportion of hospitalizations occurring at non-study facilities to adjust for hospitalizations missed through facility-based surveillance. Results: HUS showed that 69% and 67% of hospitalizations occurred at study facilities at Ballabgarh and Vadu, respectively. Overall, 6004 patients hospitalized with acute medical illness at participating facilities were enrolled (1717 from Ballabgarh; 4287 from Vadu). The proportion of patients with influenza was higher at Vadu than Ballabgarh annually (2010: 21% vs. 5%, p < 0.05; 2011: 18% vs. 5%, p < 0.05; 2012: 23% vs. 5%, p < 0.05). Annual adjusted influenza-associated hospitalization rates were 5-11 fold higher in Vadu (20.3-51.6 per 10,000) vs Ballabgarh (4.4-6.3 per 10,000). At both sites, influenza A/H1N1pdm09 and B predominated during 2010, A/H3N2 and B during 2011, and A/H1N1pdm09 and B during 2012. Conclusion: The markedly different influenza hospitalization rates by season and across communities in India highlight the need for sustained multi-site surveillance system for estimating national influenza disease burden. That would be the first step for initiating discussions around Influenza prevention and control strategies in the country. (C) 2014 Published by Elsevier Ltd on behalf of The British Infection Association. C1 [Hirve, Siddhivinayak; Lele, Pallavi; Juvekar, Sanjay] King Edward Mem Hosp, Res Ctr, Vadu Rural Hlth Program, Pune, Maharashtra, India. [Krishnan, Anand; Rai, Sanjay] All India Inst Med Sci, Ctr Community Med, New Delhi, India. [Dawood, Fatimah S.; Saha, Siddhartha; Lafond, Kathryn E.; Lal, Renu B.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Influenza Div, Atlanta, GA USA. [Potdar, Varsha] Indian Council Med Res, Natl Inst Virol, Pune 411001, Maharashtra, India. [Broor, Shobha] INCLEN Trust Int, New Delhi, India. [Gupta, Vivek] Natl Inst Mental Hlth & Allied Sci, Bangalore, Karnataka, India. RP Chadha, M (reprint author), Indian Council Med Res, Natl Inst Virol, 20-A,Dr Ambedkar Rd, Pune 411001, Maharashtra, India. EM mscniv@gmail.com FU US Centers for Disease Control and Prevention [1U01IP000206]; National Institute of Virology, Pune [1U01IP000206] FX This study was funded through cooperative agreement 1U01IP000206 between the US Centers for Disease Control and Prevention and the National Institute of Virology, Pune. NR 21 TC 3 Z9 3 U1 1 U2 2 PU W B SAUNDERS CO LTD PI LONDON PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND SN 0163-4453 EI 1532-2742 J9 J INFECTION JI J. Infect. PD FEB PY 2015 VL 70 IS 2 BP 160 EP 170 DI 10.1016/j.jinf.2014.08.015 PG 11 WC Infectious Diseases SC Infectious Diseases GA AZ2BQ UT WOS:000348039900007 PM 25218056 ER PT J AU Makani, J Soka, D Rwezaula, S Krag, M Mghamba, J Ramaiya, K Cox, SE Grosse, SD AF Makani, Julie Soka, Deogratias Rwezaula, Stella Krag, Marlene Mghamba, Janneth Ramaiya, Kaushik Cox, Sharon E. Grosse, Scott D. TI Health policy for sickle cell disease in Africa: experience from Tanzania on interventions to reduce under-five mortality SO TROPICAL MEDICINE & INTERNATIONAL HEALTH LA English DT Article DE public health; sickle cell anaemia; Africa; mortality; morbidity; trends; health policy; childhood mortality; newborn screening; pneumococcal vaccines ID GLOBAL EPIDEMIOLOGY; CHILDREN; ANEMIA; CARE; HEMOGLOBIN; SURVIVAL; IMPACT AB Tanzania has made considerable progress towards reducing childhood mortality, achieving a 57% decrease between 1980 and 2011. This epidemiological transition will cause a reduction in the contribution of infectious diseases to childhood mortality and increase in contribution from non-communicable diseases (NCDs). Haemoglobinopathies are amongst the most common childhood NCDs, with sickle cell disease (SCD) being the commonest haemoglobinopathy in Africa. In Tanzania, 10313 children with SCD under 5years of age (U5) are estimated to die every year, contributing an estimated 7% of overall deaths in U5 children. Key policies that governments in Africa are able to implement would reduce mortality in SCD, focusing on newborn screening and comprehensive SCD care programmes. Such programmes would ensure that interventions such as prevention of infections using penicillin plus prompt diagnosis and treatment of complications are provided to all individuals with SCD. C1 [Makani, Julie; Soka, Deogratias; Cox, Sharon E.] Muhimbili Univ Hlth & Allied Sci, Muhimbili Wellcome Programme, Dar Es Salaam, Tanzania. [Makani, Julie; Rwezaula, Stella] Muhimbili Natl Hosp, Dar Es Salaam, Tanzania. [Makani, Julie] Univ Oxford, Oxford, England. [Krag, Marlene] Univ Copenhagen, Inst Int Hlth Immunol & Microbiol, Copenhagen, Denmark. [Mghamba, Janneth; Ramaiya, Kaushik] Minist Hlth & Social Welf, Dar Es Salaam, Tanzania. [Cox, Sharon E.] London Sch Hyg & Trop Med, London WC1, England. [Grosse, Scott D.] Ctr Dis Control & Prevent, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. RP Makani, J (reprint author), Muhimbili Univ Hlth & Allied Sci, Muhimbili Wellcome Programme, POB 65001, Dar Es Salaam, Tanzania. EM julie.makani@muhimbili-wellcome.org OI Cox, Sharon/0000-0002-9908-2936 FU Wellcome Trust, UK; Muhimbili National Hospital; Ministry of Health and Social Welfare; Muhimbili University of Health and Allied Sciences; Oxford University FX The authors thank the patients and staff of Muhimbili SCD Programme, Muhimbili National Hospital and Muhimbili University of Health and Allied Sciences, Dar-es-Salaam, Tanzania. They also wish to thank C. Newton, D. Weatherall, F. Kirkham, D. Roberts, J Mgaya and T. Marlowe for their comments on the manuscript and contribution to the SCD programme. This study received financial support from the Wellcome Trust, UK, Muhimbili National Hospital, Ministry of Health and Social Welfare, Muhimbili University of Health and Allied Sciences and Oxford University. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 20 TC 7 Z9 7 U1 0 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1360-2276 EI 1365-3156 J9 TROP MED INT HEALTH JI Trop. Med. Int. Health PD FEB PY 2015 VL 20 IS 2 BP 184 EP 187 DI 10.1111/tmi.12428 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AY9UK UT WOS:000347895700007 PM 25365928 ER PT J AU Bond, KT Frye, V Taylor, R Williams, K Bonner, S Lucy, D Cupid, M Weiss, L Koblin, BA AF Bond, Keosha T. Frye, Victoria Taylor, Raekiela Williams, Kim Bonner, Sebastian Lucy, Debbie Cupid, Malik Weiss, Linda Koblin, Beryl A. CA Straight Talk Study Team TI Changing access to mental health care and social support when people living with HIV/AIDS become service providers SO AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV LA English DT Article DE work-related stress; principles of GIPA/MEIPA; PHA service providers; emotional labor; employment transition ID AFRICAN-AMERICAN MEN; UNITED-STATES; HIV-INFECTION; CONDOM USE; KNOWLEDGE; RISK; STIGMA; TRANSMISSION; PREVALENCE; BEHAVIORS AB As people living with HIV/AIDS (PHAs) achieve more stable health, many have taken on active peer support and professional roles within AIDS service organizations. Although the increased engagement has been associated with many improved health outcomes, emerging program and research evidence have identified new challenges associated with such transition. This paper reports on the results of a qualitative interpretive study that explored the effect of this role transition on PHA service providers' access to mental health support and self care. A total of 27 PHA service providers of diverse ethno-racial backgrounds took part in the study. Results show that while role transition often improves access to financial and health-care benefits, it also leads to new stress from workload demands, emotional triggers from client's narratives, feeling of burnout from over-immersion in HIV at both personal and professional levels, and diminished self care. Barriers to seeking support included: concerns regarding confidentiality; self-imposed and enacted stigma associated with accessing mental health services; and boundary issues resulting from changes in relationships with peers and other service providers. Evolving support mechanisms included: new formal and informal peer support networks amongst colleagues or other PHA service providers to address both personal and professional challenges, and having access to professional support offered through the workplace. The findings suggest the need for increased organizational recognition of HIV support work as a form of emotional labor that places complex demands on PHA service providers. Increased access to employer-provided mental health services, supportive workplace policies, and adequate job-specific training will contribute to reduced work-related stress. Community level strategies that support expansion of social networks amongst PHA service providers would reduce isolation. Systemic policies to increase access to insurance benefits and enhance sector-wide job preparedness and post-employment support will sustain long-term and meaningful involvement of PHAs in service provision. C1 [Bond, Keosha T.] Columbia Univ, Teachers Coll, Dept Hlth & Behav Studies, New York, NY 10027 USA. [Bond, Keosha T.; Bonner, Sebastian; Cupid, Malik] New York Acad Med, Ctr Urban Epidemiol Studies, New York, NY USA. [Frye, Victoria] New York Blood Ctr, Lindsley F Kimball Res Inst, Lab Social & Behav Sci, New York, NY 10021 USA. [Frye, Victoria] Columbia Univ, Mailman Sch Publ Hlth, Dept Sociomed Sci, New York, NY USA. [Taylor, Raekiela; Williams, Kim] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. [Lucy, Debbie; Koblin, Beryl A.] New York Blood Ctr, Lindsley F Kimball Res Inst, Lab Infect Dis Prevent, New York, NY 10021 USA. [Weiss, Linda] New York Acad Med, Ctr Evaluat & Appl Res, New York, NY USA. RP Bond, KT (reprint author), Columbia Univ, Teachers Coll, Dept Hlth & Behav Studies, New York, NY 10027 USA. EM kb2333@tc.columbia.edu FU NCHHSTP CDC HHS [1-UR6/PS-000667-01, UR6 PS000667]; NIDA NIH HHS [T32 DA007233] NR 31 TC 1 Z9 1 U1 1 U2 12 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0954-0121 EI 1360-0451 J9 AIDS CARE JI Aids Care-Psychol. Socio-Med. Asp. Aids-Hiv PD FEB 1 PY 2015 VL 27 IS 2 BP 182 EP 188 DI 10.1080/09540121.2014.940269 PG 7 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychology, Multidisciplinary; Respiratory System; Social Sciences, Biomedical SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychology; Respiratory System; Biomedical Social Sciences GA AY4BN UT WOS:000347523300007 PM 25298014 ER PT J AU Cheung, K Rasberry, CN Dunville, RL Buckley, R Cook, D Daniels, B Robin, L AF Cheung, Karen Rasberry, Catherine N. Dunville, Richard L. Buckley, Rebekah Cook, Deborah Daniels, Brandy Robin, Leah TI A Multicomponent School-Based Asthma Management Program: Enhancing Connections to Clinical Care SO JOURNAL OF SCHOOL HEALTH LA English DT Article C1 [Cheung, Karen] ICF Int, Seattle, WA 98104 USA. [Rasberry, Catherine N.; Dunville, Richard L.; Robin, Leah] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div Adolescent Hlth, Atlanta, GA 30329 USA. [Buckley, Rebekah] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Populat Hlth, Atlanta, GA 30341 USA. [Cook, Deborah] Kennett Publ Sch, Kennett, MO 63851 USA. [Daniels, Brandy] ICF Int, Atlanta, GA 30329 USA. RP Rasberry, CN (reprint author), Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div Adolescent Hlth, 1600 Clifton Rd,MS E-75, Atlanta, GA 30329 USA. EM karen.cheung@icfi.com; CRasberry@cdc.gov; RDunville@cdc.gov; eut9@cdc.gov; dcook@kennett.k12.mo.us; Brandy.Daniels@icfi.com; LRobin@cdc.gov RI Rasberry, Catherine/P-1984-2016 OI Rasberry, Catherine/0000-0001-8256-6961 FU Intramural CDC HHS [CC999999] NR 15 TC 2 Z9 2 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-4391 EI 1746-1561 J9 J SCHOOL HEALTH JI J. Sch. Health PD FEB PY 2015 VL 85 IS 2 BP 135 EP 140 DI 10.1111/josh.12226 PG 6 WC Education & Educational Research; Education, Scientific Disciplines; Health Care Sciences & Services; Public, Environmental & Occupational Health SC Education & Educational Research; Health Care Sciences & Services; Public, Environmental & Occupational Health GA AY4II UT WOS:000347541000008 PM 25564982 ER PT J AU Coleman, CN Sullivan, JM Bader, JL Murrain-Hill, P Koerner, JF Garrett, AL Weinstock, DM Case, C Hrdina, C Adams, SA Whitcomb, RC Graeden, E Shankman, R Lant, T Maidment, BW Hatchett, RC AF Coleman, C. Norman Sullivan, Julie M. Bader, Judith L. Murrain-Hill, Paula Koerner, John F. Garrett, Andrew L. Weinstock, David M. Case, Cullen, Jr. Hrdina, Chad Adams, Steven A. Whitcomb, Robert C. Graeden, Ellie Shankman, Robert Lant, Timothy Maidment, Bert W. Hatchett, Richard C. TI PUBLIC HEALTH AND MEDICAL PREPAREDNESS FOR A NUCLEAR DETONATION: THE NUCLEAR INCIDENT MEDICAL ENTERPRISE SO HEALTH PHYSICS LA English DT Article DE National Council on Radiation Protection and Measurements; emergency planning; nuclear war; radiological terrorism ID SCARCE RESOURCES; RADIATION VICTIMS; GLOBAL CONSENSUS; DECISION-MODEL; MASS-CASUALTY; MANAGEMENT; EMERGENCIES; ALLOCATION; TRIAGE; TOOLS AB Resilience and the ability to mitigate the consequences of a nuclear incident are enhanced by (1) effective planning, preparation and training; (2) ongoing interaction, formal exercises, and evaluation among the sectors involved; (3) effective and timely response and communication; and (4) continuous improvements based on new science, technology, experience, and ideas. Public health and medical planning require a complex, multifaceted systematic approach involving federal, state, local, tribal, and territorial governments; private sector organizations; academia; industry; international partners; and individual experts and volunteers. The approach developed by the U.S. Department of Health and Human Services Nuclear Incident Medical Enterprise (NIME) is the result of efforts from government and nongovernment experts. It is a "bottom-up" systematic approach built on the available and emerging science that considers physical infrastructure damage, the spectrum of injuries, a scarce resources setting, the need for decision making in the face of a rapidly evolving situation with limited information early on, timely communication, and the need for tools and just-in-time information for responders who will likely be unfamiliar with radiation medicine and uncertain and overwhelmed in the face of the large number of casualties and the presence of radioactivity. The components of NIME can be used to support planning for, response to, and recovery from the effects of a nuclear incident. Recognizing that it is a continuous work-in-progress, the current status of the public health and medical preparedness and response for a nuclear incident is provided. C1 [Coleman, C. Norman; Sullivan, Julie M.; Bader, Judith L.; Murrain-Hill, Paula; Koerner, John F.; Garrett, Andrew L.; Shankman, Robert] Dept Hlth & Human Serv, Off Emergency Management, Off Assistant Secretary Preparedness & Response, Washington, DC USA. [Coleman, C. Norman] NCI, Radiat Res Program, Div Canc Treatment & Diag, Bethesda, MD 20892 USA. [Weinstock, David M.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Weinstock, David M.; Case, Cullen, Jr.] Natl Marrow Donor Program, Radiat Injury Treatment Network, Minneapolis, MN USA. [Hrdina, Chad] Dept Hlth & Human Serv, Off Policy & Planning, Off Assistant Secretary Preparedness & Response, Washington, DC USA. [Adams, Steven A.] Ctr Dis Control & Prevent, Div Strateg Natl Stockpile, Off Publ Hlth Preparedness & Response, Atlanta, GA USA. [Whitcomb, Robert C.] Ctr Dis Control & Prevent, Radiat Studies Branch, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Atlanta, GA USA. [Graeden, Ellie] Gryphon Sci LLC, Rockville, MD USA. [Lant, Timothy; Hatchett, Richard C.] Dept Hlth & Human Serv, Biomed Adv Res & Dev Author, Off Assistant Secretary Preparedness & Response, Washington, DC USA. [Maidment, Bert W.] NIAID, Radiat Nucl Countermeasures Program, NIH, Bethesda, MD 20892 USA. RP Coleman, CN (reprint author), NCI, Radiat Res Program, Div Canc Treatment & Diag, Bethesda, MD 20892 USA. EM ccoleman@mail.nih.gov FU Intramural NIH HHS [Z99 CA999999] NR 53 TC 9 Z9 9 U1 2 U2 23 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD FEB PY 2015 VL 108 IS 2 BP 149 EP 160 DI 10.1097/HP.0000000000000249 PG 12 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA AX6YN UT WOS:000347064100011 PM 25551496 ER PT J AU McElroy, AK Erickson, BR Flietstra, TD Rollin, PE Towner, JS Nichol, ST Spiropoulou, CF AF McElroy, Anita K. Erickson, Bobbie R. Flietstra, Timothy D. Rollin, Pierre E. Towner, Jonathan S. Nichol, Stuart T. Spiropoulou, Christina F. TI Von Willebrand Factor Is Elevated in Individuals Infected with Sudan Virus and Is Associated with Adverse Clinical Outcomes SO VIRAL IMMUNOLOGY LA English DT Article ID COAGULATION; ADAMTS-13; DISEASES; DENGUE; CELLS AB Sudan virus (SUDV) is a member of the Filoviridae family that has been associated with sporadic outbreaks of human disease in sub-Saharan Africa. The filoviruses are notable for the high frequencies with which they cause both hemorrhagic manifestations and death in infected individuals. Recently, we reported an extensive biomarker analysis of patient specimens from the Gulu SUDV outbreak. In that study, we found evidence of endothelial dysfunction and alterations of factors important to the coagulation pathways. The complex intersection between the endothelium, coagulation, and immunity is further explored in this study where we examine several additional biomarkers using the same patient specimens. We report that von Willebrand factor (vWF), a protein that promotes platelet adhesion to the injured endothelium, is elevated in SUDV-infected individuals compared to normally reported values in healthy individuals. Furthermore, vWF is associated with a fatal outcome in SUDV-infected pediatric patients. In addition, we find that vWF is elevated in individuals who have hemorrhagic manifestations of disease, suggesting excessive thrombosis in these patients. C1 [McElroy, Anita K.; Erickson, Bobbie R.; Flietstra, Timothy D.; Rollin, Pierre E.; Towner, Jonathan S.; Nichol, Stuart T.; Spiropoulou, Christina F.] US Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Atlanta, GA 30333 USA. [McElroy, Anita K.] Emory Univ Sch Med, Div Pediat Infect Dis, Atlanta, GA USA. RP McElroy, AK (reprint author), US Ctr Dis Control & Prevent, Viral Special Pathogens Branch, 1600 Clifton Rd MS G14, Atlanta, GA 30333 USA. EM gsz5@cdc.gov FU PIDS/St. Jude Fellowship Award; Atlanta Pediatric Scholars Award [NIH K12 HD072245] FX A.K.M is supported by the PIDS/St. Jude Fellowship Award and the Atlanta Pediatric Scholars Award (NIH K12 HD072245). This work was performed while she held an NIH Loan Repayment Award. NR 17 TC 3 Z9 3 U1 0 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0882-8245 EI 1557-8976 J9 VIRAL IMMUNOL JI Viral Immunol. PD FEB 1 PY 2015 VL 28 IS 1 SI SI BP 71 EP 73 DI 10.1089/vim.2014.0072 PG 3 WC Immunology; Virology SC Immunology; Virology GA AY4AH UT WOS:000347520100009 PM 25387000 ER PT J AU Singh, A Datta, S Sachdeva, A Maslanka, S Dykes, J Skinner, G Burr, D Whiting, RC Sharma, SK AF Singh, Ajay Datta, Shomik Sachdeva, Amita Maslanka, Susan Dykes, Janet Skinner, Guy Burr, Donald Whiting, Richard C. Sharma, Shashi K. TI EVALUATION OF AN ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA) KIT FOR THE DETECTION OF BOTULINUM NEUROTOXINS A, B, E, AND F IN SELECTED FOOD MATRICES SO HEALTH SECURITY LA English DT Article ID CLOSTRIDIUM-BOTULINUM; TOXINS; TECHNOLOGIES AB The mouse bioassay (MBA) is the only accepted standard method for detection of botulinum neurotoxins (BoNTs) in foods. The ELISA method has several advantages over the MBA and is therefore widely used for in vitro detection of BoNTs. The US Food and Drug Administration (FDA) and the Centers for Disease Control and Prevention (CDC) conducted a precollaborative study to evaluate the applicability of Botulinum Toxin ELISA kits for the detection of BoNT serotypes A, B, E, and F in a variety of food matrices. In this study, food samples (eg, broccoli, salami, smoked salmon, green beans, orange juice, tomato juice, low-fat plain yogurt, whole milk, liquid infant formula milk, and liquid eggs) were spiked with high, medium, and low concentration BoNT serotypes A, B, E, and F. Samples (unspiked and spiked) were tested at both laboratories by the ELISA kits. All food samples were positive for BoNTs by ELISA in both laboratories at medium and high spiking levels; a positive ELISA result in low spiked samples was both serotype and laboratory dependent. Overall, the ELISA method appears to be an effective preliminary screening method for BoNT detection in food matrices. C1 [Singh, Ajay; Datta, Shomik; Sachdeva, Amita] US FDA, Off Regulatory Sci, Ctr Food Safety & Appl Nutr, College Pk, MD USA. [Singh, Ajay; Datta, Shomik; Sachdeva, Amita; Maslanka, Susan; Dykes, Janet; Skinner, Guy; Burr, Donald; Whiting, Richard C.; Sharma, Shashi K.] US Dept Energy Inst, Oak Ridge Inst Sci & Educ, Washington, DC USA. [Datta, Shomik] Vorsight LLC, Arlington, VA USA. [Sachdeva, Amita] Emergent Biosolut, Gaithersburg, MD USA. [Maslanka, Susan; Dykes, Janet] Ctr Dis Control & Prevent, CDC, Natl Botulism Lab Team, Atlanta, GA USA. [Skinner, Guy] US FDA, Inst Food Safety & Hlth, Ctr Food Safety & Appl Nutr, Bedford Pk, IL USA. [Burr, Donald] US FDA, Off Regulatory Affairs, Off Regulatory Sci, Rockville, MD USA. [Whiting, Richard C.] Exponent, Chem Regulat & Food Safety, Bowie, MD USA. [Sharma, Shashi K.] US FDA, Special Pathogen Team, Off Regulatory Sci, Ctr Food Safety & Appl Nutr, College Pk, MD USA. RP Sharma, SK (reprint author), FDA CFSAN, Div Microbiol, Off Regulatory Sci, Room 4E023,5100 Paint Branch Pkwy,HFS-711, College Pk, MD 20740 USA. EM Shashi.Sharma@fda.hhs.gov NR 16 TC 1 Z9 1 U1 3 U2 6 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 2326-5094 EI 2326-5108 J9 HEALTH SECUR JI Health Secur. PD FEB 1 PY 2015 VL 13 IS 1 BP 37 EP 44 DI 10.1089/hs.2014.0075 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DD0FT UT WOS:000369596500004 PM 25812427 ER PT J AU Appelgren, KE Kraft, JM Hatfield-Timajchy, K Kottke, M Sales, J Goedken, P Kourtis, AP AF Appelgren, Kristie E. Kraft, Joan Marie Hatfield-Timajchy, Kendra Kottke, Melissa Sales, Jessica Goedken, Peggy Kourtis, Athena P. TI PREDICTORS OF CONDOM AND CONTRACEPTIVE USE DIFFER BETWEEN YOUNGER AND OLDER ADOLESCENTS SO JOURNAL OF ADOLESCENT HEALTH LA English DT Meeting Abstract C1 [Appelgren, Kristie E.; Kraft, Joan Marie; Hatfield-Timajchy, Kendra; Kourtis, Athena P.] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Kottke, Melissa; Goedken, Peggy] Emory Univ, Atlanta, GA 30322 USA. [Sales, Jessica] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X EI 1879-1972 J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD FEB PY 2015 VL 56 IS 2 SU 1 MA 68 BP S36 EP S37 PG 2 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA DK6XU UT WOS:000375069900069 ER PT J AU Becasen, J Habel, M Kachur, R Dittus, P AF Becasen, Jeffrey Habel, Melissa Kachur, Rachel Dittus, Patricia TI SEXUAL AND HEALTHCARE SEEKING BEHAVIORS OF YOUNG ADULTS BY COLLEGE ENROLLMENT SO JOURNAL OF ADOLESCENT HEALTH LA English DT Meeting Abstract C1 [Becasen, Jeffrey; Habel, Melissa; Kachur, Rachel; Dittus, Patricia] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X EI 1879-1972 J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD FEB PY 2015 VL 56 IS 2 SU 1 MA 138 BP S72 EP S72 PG 1 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA DK6XU UT WOS:000375069900139 ER PT J AU Habel, MA Becasen, JS Dittus, PJ AF Habel, Melissa A. Becasen, Jeffrey S. Dittus, Patricia J. TI THE STATE OF SEXUAL HEALTH SERVICES AT US COLLEGES & UNIVERSITIES SO JOURNAL OF ADOLESCENT HEALTH LA English DT Meeting Abstract C1 [Habel, Melissa A.; Dittus, Patricia J.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Becasen, Jeffrey S.] Ctr Dis Control & Prevent, Oakridge Inst Sci & Educ, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X EI 1879-1972 J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD FEB PY 2015 VL 56 IS 2 SU 1 MA 143 BP S74 EP S75 PG 2 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA DK6XU UT WOS:000375069900144 ER PT J AU Steiner, RJ Rasberry, CN AF Steiner, Riley J. Rasberry, Catherine N. TI ASSOCIATIONS BETWEEN IN-PERSON AND ELECTRONIC BULLYING VICTIMIZATION AND MISSING SCHOOL BECAUSE OF SAFETY CONCERNS AMONG US HIGH SCHOOL STUDENTS SO JOURNAL OF ADOLESCENT HEALTH LA English DT Meeting Abstract C1 [Steiner, Riley J.; Rasberry, Catherine N.] Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X EI 1879-1972 J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD FEB PY 2015 VL 56 IS 2 SU 1 MA 163 BP S84 EP S84 PG 1 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA DK6XU UT WOS:000375069900164 ER PT J AU Wallace, SA Strike, S Glasgow, M Orejudos, I Williams, S Fullilove, R AF Wallace, Scyatta A. Strike, Sloan Glasgow, Marcia Orejudos, Irene Williams, Samantha Fullilove, Robert TI HEALTH STATUS AND HEALTH CARE UTILIZATION AMONG FORMALLY INCARCERATED YOUNG ADULT BLACK MEN SO JOURNAL OF ADOLESCENT HEALTH LA English DT Meeting Abstract C1 [Wallace, Scyatta A.; Strike, Sloan; Glasgow, Marcia; Orejudos, Irene] St Johns Univ, New York, NY USA. [Williams, Samantha] Ctr Dis Control & Prevent, Atlanta, GA USA. [Fullilove, Robert] Columbia Univ, Mailman Sch Publ Hlth, New York, NY 10027 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X EI 1879-1972 J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD FEB PY 2015 VL 56 IS 2 SU 1 MA 88 BP S47 EP S47 PG 1 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA DK6XU UT WOS:000375069900089 ER PT J AU Kazzi, Z Buzzell, J Bertelli, L Christensen, D AF Kazzi, Ziad Buzzell, Jennifer Bertelli, Luiz Christensen, Doran TI Emergency Department Management of Patients Internally Contaminated with Radioactive Material SO EMERGENCY MEDICINE CLINICS OF NORTH AMERICA LA English DT Article DE Radioactive terrorism; Contamination; Radioactive elements; Radiation dosage; Chelation therapy ID UNITED-STATES; GOIANIA; RESIDENTS; ACCIDENT; INCIDENT AB After a radiation emergency that involves the dispersal of radioactive material, patients can become externally and internally contaminated with 1 or more radionuclides. Internal contamination can lead to the delivery of harmful ionizing radiation doses to various organs and tissues or the whole body. The clinical consequences can range from acute radiation syndrome to the long-term development of cancer. Estimating the amount of radioactive material absorbed into the body can guide the management of patients. Treatment includes, in addition to supportive care and long term monitoring, certain medical countermeasures like Prussian blue, calcium diethylenetriamine pentaacetic acid (DTPA) and zinc DTPA. C1 [Kazzi, Ziad; Buzzell, Jennifer] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Kazzi, Ziad] Emory Univ, Dept Emergency Med, Atlanta, GA 30322 USA. [Bertelli, Luiz] Los Alamos Natl Lab, Los Alamos, NM 87545 USA. [Christensen, Doran] Radiat Emergency Assistance Ctr, Oak Ridge, TN 37831 USA. RP Kazzi, Z (reprint author), 4770 Buford Highway Norhteast,MS F59, Atlanta, GA 30341 USA. EM ZKAZZI@emory.edu NR 55 TC 2 Z9 2 U1 2 U2 12 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0733-8627 EI 1558-0539 J9 EMERG MED CLIN N AM JI Emerg. Med. Clin. N. Am. PD FEB PY 2015 VL 33 IS 1 BP 179 EP + DI 10.1016/j.emc.2014.09.008 PG 19 WC Emergency Medicine SC Emergency Medicine GA AW6PS UT WOS:000346391800012 PM 25455668 ER PT J AU Escoffery, C Hannon, P Maxwell, AE Vu, T Leeman, J Dwyer, A Mason, C Sowles, S Rice, K Gressard, L AF Escoffery, Cam Hannon, Peggy Maxwell, Annette E. Vu, Thuy Leeman, Jennifer Dwyer, Andrea Mason, Caitlin Sowles, Shaina Rice, Ketra Gressard, Lindsay TI Assessment of training and technical assistance needs of Colorectal Cancer Control Program Grantees in the US SO BMC PUBLIC HEALTH LA English DT Article DE Colorectal neoplasms; Early detection and screening; Technical assistance; Training; Evidence-based interventions; Cancer screening ID EVIDENCE-BASED INTERVENTIONS; HEALTH-CARE PROVIDERS; INCREASE RECOMMENDATION; UNITED-STATES; IMPLEMENTATION; PREVENTION; FRAMEWORK; BREAST; PRACTITIONERS; DISSEMINATION AB Background: Practitioners often require training and technical assistance to build their capacity to select, adapt, and implement evidence-based interventions (EBIs). The CDC Colorectal Cancer Control Program (CRCCP) aims to promote CRC screening to increase population-level screening. This study identified the training and technical assistance (TA) needs and preferences for training related to the implementation of EBIs among CRCCP grantees. Methods: Twenty-nine CRCCP grantees completed an online survey about their screening activities, training and technical assistance in 2012. They rated desire for training on various evidence-based strategies to increase cancer screening, evidence-based competencies, and program management topics. They also reported preferences for training formats and facilitators and barriers to trainings. Results: Many CRCCP grantees expressed the need for training with regards to specific EBIs, especially system-level and provider-directed EBIs to promote CRC screening. Grantees rated these EBIs as more difficult to implement than client-oriented EBIs. Grantees also reported a moderate need for training regarding finding EBIs, assessing organizational capacity, implementing selected EBIs, and conducting process and outcome evaluations. Other desired training topics reported with higher frequency were partnership development and data collection/evaluation. Grantees preferred training formats that were interactive such as on-site trainings, webinars or expert consultants. Conclusions: Public health organizations need greater supports for adopting evidence-based interventions, working with organizational-level change, partnership development and data management. Future capacity building efforts for the adoption of EBIs should focus on systems or provider level interventions and key processes for health promotion and should be delivered in a variety of ways to assist local organizations in cancer prevention and control. C1 [Escoffery, Cam] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Hannon, Peggy; Vu, Thuy] Univ Washington, Hlth Promot Res Ctr, Seattle, WA 98105 USA. [Maxwell, Annette E.] Univ Calif Los Angeles, Los Angeles, CA 90095 USA. [Leeman, Jennifer] Univ N Carolina, Sch Nursing, Chapel Hill, NC 27599 USA. [Dwyer, Andrea] Univ Colorado, Aurora, CO 80045 USA. [Mason, Caitlin] Univ Washington, Dept Hlth Serv, Seattle, WA 98105 USA. [Sowles, Shaina] Washington Univ, St Louis, MO 63112 USA. [Rice, Ketra; Gressard, Lindsay] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA 30341 USA. RP Escoffery, C (reprint author), Emory Univ, Rollins Sch Publ Hlth, 1518 Clifton Rd,5th Floor, Atlanta, GA 30322 USA. EM cescoff@emory.edu OI Sowles, Shaina/0000-0002-2419-1089 FU Centers for Disease Control and Prevention (CDC) [U48DP001909, U48DP001934, U48DP001938, U48DP001944, U48DP001911, U48-DP001903] FX This publication was supported by the Centers for Disease Control and Prevention (CDC) through the Cancer Prevention and Control Research Network, a network within the CDC's Prevention Research Centers Program (Emory University, U48DP001909; University of California at Los Angeles, U48DP001934; University of Colorado, U48DP001938; University of North Carolina at Chapel Hill, U48DP001944; University of Washington, U48DP001911; Washington University, U48-DP001903). The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 38 TC 0 Z9 0 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD JAN 31 PY 2015 VL 15 AR 49 DI 10.1186/s12889-015-1386-1 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CB1WN UT WOS:000349418800014 PM 25636329 ER EF