FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Landman, KZ Tan, KR Arguin, PM AF Landman, Keren Z. Tan, Kathrine R. Arguin, Paul M. TI Knowledge, Attitudes, and Practices Regarding Antimalarial Chemoprophylaxis in US Peace Corps Volunteers - Africa, 2013 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID TRAVELERS C1 [Landman, Keren Z.] CDC, Atlanta, GA 30333 USA. [Landman, Keren Z.; Tan, Kathrine R.; Arguin, Paul M.] CDC, Malaria Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30333 USA. RP Landman, KZ (reprint author), CDC, Atlanta, GA 30333 USA. EM klandman@cdc.gov NR 4 TC 6 Z9 7 U1 0 U2 0 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JUN 13 PY 2014 VL 63 IS 23 BP 516 EP 517 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AJ4KN UT WOS:000337645300003 PM 24918487 ER PT J AU Chiang, CF Albarino, CG Lo, MK Spiropoulou, CF AF Chiang, Cheng-Feng Albarino, Cesar G. Lo, Michael K. Spiropoulou, Christina F. TI Small Interfering RNA Inhibition of Andes Virus Replication SO PLOS ONE LA English DT Article ID HANTAVIRUS CARDIOPULMONARY SYNDROME; PULMONARY SYNDROME; NUCLEOCAPSID PROTEIN; ANTIVIRAL IMMUNITY; MOSQUITO CELLS; DOUBLE-BLIND; TRANSMISSION; INFECTIONS; RESISTANCE; RIBAVIRIN AB Andes virus (ANDV) is the most common causative agent of hantavirus pulmonary syndrome (HPS) in the Americas, and is the only hantavirus associated with human-to-human transmission. Case fatality rates of ANDV-induced HPS are approximately 40%. There are currently no effective vaccines or antivirals against ANDV. Since HPS severity correlates with viral load, we tested small interfering RNA (siRNA) directed against ANDV genes as a potential antiviral strategy. We designed pools of 4 siRNAs targeting each of the ANDV genome segments (S, M, and L), and tested their efficacy in reducing viral replication in vitro. The siRNA pool targeting the S segment reduced viral transcription and replication in Vero-E6 cells more efficiently than those targeting the M and L segments. In contrast, siRNAs targeting the S, M, or L segment were similar in their ability to reduce viral replication in human lung microvascular endothelial cells. Importantly, these siRNAs inhibit ANDV replication even if given after infection. Taken together, our findings indicate that siRNAs targeting the ANDV genome efficiently inhibit ANDV replication, and show promise as a strategy for developing therapeutics against ANDV infection. C1 [Chiang, Cheng-Feng; Albarino, Cesar G.; Lo, Michael K.; Spiropoulou, Christina F.] Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA 30333 USA. RP Spiropoulou, CF (reprint author), Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA 30333 USA. EM cspiropoulou@cdc.gov OI Lo, Michael/0000-0002-0409-7896; Chiang, Cheng-Feng/0000-0002-3617-9124 FU Centers for Disease Control and Prevention (CDC) FX This work was funded by Centers for Disease Control and Prevention (CDC) core funding. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 37 TC 3 Z9 3 U1 1 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 12 PY 2014 VL 9 IS 6 AR e99764 DI 10.1371/journal.pone.0099764 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AK8TP UT WOS:000338701300091 PM 24924189 ER PT J AU Pondo, T Rose, CE Martin, SW Keitel, WA Keyserling, HL Babcock, J Parker, S Jacobson, RM Poland, GA McNeil, MM AF Pondo, Tracy Rose, Charles E., Jr. Martin, Stacey W. Keitel, Wendy A. Keyserling, Harry L. Babcock, Janiine Parker, Scott Jacobson, Robert M. Poland, Gregory A. McNeil, Michael M. TI Evaluation of sex, race, body mass index and pre-vaccination serum progesterone levels and post-vaccination serum anti-anthrax protective immunoglobulin G on injection site adverse events following anthrax vaccine adsorbed (AVA) in the CDC AVA human clinical trial SO VACCINE LA English DT Article DE Anthrax vaccine adsorbed; Anthrax vaccines/adverse events; Sex factors; Race; Body mass index; Immunological response ID IMMUNE-RESPONSES; RANDOMIZED-TRIAL; SAFETY PROFILE; IMMUNOGENICITY; DISABILITY; IMMUNIZATION; PREGNANCY; HORMONES; GENDER; SYSTEM AB Background: Anthrax vaccine adsorbed (AVA) administered intramuscularly (IM) results in fewer adverse events (AEs) than subcutaneous (SQ) administration. Women experience more AEs than men. Antibody response, female hormones, race, and body mass index (BMI) may contribute to increased frequency of reported injection site AEs. Methods: We analyzed data from the CDC AVA human clinical trial. This double blind, randomized, placebo controlled trial enrolled 1563 participants and followed them through 8 injections (AVA or placebo) over a period of 42 months. For the trial's vaccinated cohort (n = 1267), we used multivariable logistic regression to model the effects of study group (SQ or IM), sex, race, study site, BMI, age, and post-vaccination serum anti-PA IgG on occurrence of AEs of any severity grade. Also, in a women-only subset (n = 227), we assessed effect of pre-vaccination serum progesterone level and menstrual phase on AEs. Results: Participants who received SQ injections had significantly higher proportions of itching, redness, swelling, tenderness and warmth compared to the IM study group after adjusting for other risk factors. The proportions of redness, swelling, tenderness and warmth were all significantly lower in blacks vs. non-black participants. We found arm motion limitation, itching, pain, swelling and tenderness were more likely to occur in participants with the highest anti-PA IgG concentrations. In the SQ study group, redness and swelling were more common for obese participants compared to participants who were not overweight. Females had significantly higher proportions of all AEs compared to males. Menstrual phase was not associated with any AEs. Conclusions: Female and non-black participants had a higher proportion of AVA associated AEs and higher anti-PA IgG concentrations. Antibody responses to other vaccines may also vary by sex and race. Further studies may provide better understanding for higher proportions of AEs in women and non-black participants. Published by Elsevier Ltd. C1 [Pondo, Tracy; Rose, Charles E., Jr.; Martin, Stacey W.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Bacterial Dis, Atlanta, GA 30333 USA. [McNeil, Michael M.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Immunizat Safety Off, Atlanta, GA USA. [Keitel, Wendy A.] Baylor Coll Med, Houston, TX 77030 USA. [Keyserling, Harry L.] Emory Univ, Sch Med, Atlanta, GA USA. [Babcock, Janiine] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. [Parker, Scott] Univ Alabama Birmingham, Birmingham, AL USA. [Jacobson, Robert M.; Poland, Gregory A.] Mayo Clin, Rochester, MN USA. RP Pondo, T (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Bacterial Dis, Atlanta, GA 30333 USA. EM dio2@cdc.gov FU CDC FX The protocol for this study was approved by an Institutional Review Board of the Centers for Disease Control and Prevention (CDC). The funding for this study was provided solely by the CDC. NR 44 TC 11 Z9 11 U1 1 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JUN 12 PY 2014 VL 32 IS 28 BP 3548 EP 3554 DI 10.1016/j.vaccine.2014.04.025 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AL0NC UT WOS:000338822600012 PM 24768633 ER PT J AU Sudenga, SL Wiener, HW King, CC Rompalo, AM Cu-Uvin, S Klein, RS Shah, KV Sobel, JD Jamieson, DJ Shrestha, S AF Sudenga, Staci L. Wiener, Howard W. King, Caroline C. Rompalo, Anne M. Cu-Uvin, Susan Klein, Robert S. Shah, Keerti V. Sobel, Jack D. Jamieson, Denise J. Shrestha, Sadeep TI Dense Genotyping of Immune-Related Loci Identifies Variants Associated with Clearance of HPV among HIV-Positive Women in the HIV Epidemiology Research Study (HERS) SO PLOS ONE LA English DT Article ID GENOME-WIDE ASSOCIATION; HUMAN-PAPILLOMAVIRUS INFECTION; CERVICAL-CANCER; NATURAL-HISTORY; SUSCEPTIBILITY LOCI; G POLYMORPHISMS; YOUNG-WOMEN; RISK; E6; DNA AB Persistent high-risk human papillomavirus (HR-HPV) is a necessary and causal factor of cervical cancer. Most women naturally clear HPV infections; however, the biological mechanisms related to HPV pathogenesis have not been clearly elucidated. Host genetic factors that specifically regulate immune response could play an important role. All HIV-positive women in the HIV Epidemiology Research Study (HERS) with a HR-HPV infection and at least one follow-up biannual visit were included in the study. Cervicovaginal lavage samples were tested for HPV using type-specific HPV hybridization assays. Type-specific HPV clearance was defined as two consecutive HPV-negative tests after a positive test. DNA from participants was genotyped for 196,524 variants within 186 known immune related loci using the custom ImmunoChip microarray. To assess the influence of each single-nucleotide polymorphism (SNP) with HR-HPV clearance, the Cox proportional hazards model with the Wei-Lin-Weissfeld approach was used, adjusting for CD4+ count, low risk HPV (LR-HPV) co-infection, and relevant confounders. Three analytical models were performed: race-specific (African Americans (n = 258), European Americans (n = 87), Hispanics (n = 55), race-adjusted combined analysis, and meta-analysis of pooled independent race-specific analyses. Women were followed for a median time of 1,617 days. Overall, three SNPs (rs1112085, rs11102637, and rs12030900) in the MAGI-3 gene and one SNP (rs8031627) in the SMAD3 gene were associated with HR-HPV clearance (p<10(-6)). A variant (rs1633038) in HLA-G were also significantly associated in African American. Results from this study support associations of immune-related genes, having potential biological mechanism, with differential cervical HR-HPV infection outcomes. C1 [Sudenga, Staci L.; Wiener, Howard W.; Shrestha, Sadeep] Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL 35203 USA. [King, Caroline C.; Jamieson, Denise J.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA. [Rompalo, Anne M.] Johns Hopkins Univ, Sch Med, Div Infect Dis, Baltimore, MD 21205 USA. [Cu-Uvin, Susan] Brown Univ, Dept Obstet & Gynecol & Med, Providence, RI 02912 USA. [Klein, Robert S.] Mt Sinai Sch Med, New York, NY USA. [Shah, Keerti V.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA. [Sobel, Jack D.] Wayne State Univ, Sch Med, Detroit, MI USA. RP Shrestha, S (reprint author), Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL 35203 USA. EM sshrestha@uab.edu RI Sudenga, Staci/A-7726-2015 FU Pilot Project Award from the Johns Hopkins Cervical Cancer SPORE [(2P50CA098252]; NIH Cancer Prevention and Control Training Program [R25CA47888]; Centers for Disease Control and Prevention [U64/CCU106795, U64/CCU206798, U64/CCU306802, U64/CCU506831] FX Genotyping efforts were supported by the Pilot Project Award (PI: Sadeep Shrestha) from the Johns Hopkins Cervical Cancer SPORE (2P50CA098252 PI: TC Wu). The work was supported in part by the NIH Cancer Prevention and Control Training Program (R25CA47888 - fellowship of Staci Sudenga). The HIV Epidemiology Research Study (HERS) was funded through Centers for Disease Control and Prevention cooperative agreements U64/CCU106795, U64/CCU206798, U64/CCU306802, and U64/CCU506831. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 46 TC 5 Z9 5 U1 0 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 11 PY 2014 VL 9 IS 6 AR e99109 DI 10.1371/journal.pone.0099109 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AK7TQ UT WOS:000338631000048 PM 24918582 ER PT J AU Meyer, DA Torres-Altoro, MI Tan, ZJ Tozzi, A Di Filippo, M DiNapoli, V Plattner, F Kansy, JW Benkovic, SA Huber, JD Miller, DB Greengard, P Calabresi, P Rosen, CL Bibb, JA AF Meyer, Douglas A. Torres-Altoro, Melissa I. Tan, Zhenjun Tozzi, Alessandro Di Filippo, Massimiliano DiNapoli, Vincent Plattner, Florian Kansy, Janice W. Benkovic, Stanley A. Huber, Jason D. Miller, Diane B. Greengard, Paul Calabresi, Paolo Rosen, Charles L. Bibb, James A. TI Ischemic Stroke Injury Is Mediated by Aberrant Cdk5 SO JOURNAL OF NEUROSCIENCE LA English DT Article DE biomarker; calpain; Cdk5; ischemia; neuroprotection; stroke ID SYNAPTIC PLASTICITY; CEREBRAL-ISCHEMIA; CELL-DEATH; NEURODEGENERATIVE DISEASES; HUNTINGTONS-DISEASE; IN-VITRO; NEURONS; VULNERABILITY; MECHANISMS; DOPAMINE AB Ischemic stroke is one of the leading causes of morbidity and mortality. Treatment options are limited and only a minority of patients receive acute interventions. Understanding the mechanisms that mediate neuronal injury and death may identify targets for neuroprotective treatments. Here we show that the aberrant activity of the protein kinase Cdk5 is a principal cause of neuronal death in rodents during stroke. Ischemia induced either by embolic middle cerebral artery occlusion (MCAO) in vivo or by oxygen and glucose deprivation in brain slices caused calpain-dependent conversion of the Cdk5-activating cofactor p35 to p25. Inhibition of aberrant Cdk5 during ischemia protected dopamine neurotransmission, maintained field potentials, and blocked excitotoxicity. Furthermore, pharmacological inhibition or conditional knock-out (CKO) of Cdk5 prevented neuronal death in response to ischemia. Moreover, Cdk5 CKO dramatically reduced infarctions following MCAO. Thus, targeting aberrant Cdk5 activity may serve as an effective treatment for stroke. C1 [Meyer, Douglas A.; Torres-Altoro, Melissa I.; Plattner, Florian; Kansy, Janice W.; Bibb, James A.] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA. [Bibb, James A.] Univ Texas SW Med Ctr Dallas, Dept Neurol & Neurotherapeut, Dallas, TX 75390 USA. [Tan, Zhenjun; DiNapoli, Vincent; Rosen, Charles L.] W Virginia Univ, Sch Med, Dept Neurosurg, Morgantown, WV 26506 USA. [Benkovic, Stanley A.; Miller, Diane B.] NIOSH, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. [Tozzi, Alessandro; Di Filippo, Massimiliano; Calabresi, Paolo] Univ Perugia, Osped S Maria Misericordia, Neurol Clin, I-06156 Perugia, Italy. [Tozzi, Alessandro; Di Filippo, Massimiliano; Calabresi, Paolo] Fdn Santa Lucia Ist Ricovero & Cura Carattere Sci, I-00184 Rome, Italy. [Huber, Jason D.] W Virginia Univ, Sch Med, Dept Basic Pharmaceut Sci, Morgantown, WV 26506 USA. [Greengard, Paul] Rockefeller Univ, Lab Mol & Cellular Neurosci, New York, NY 10021 USA. RP Bibb, JA (reprint author), Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA. EM james.bibb@utsouthwestern.edu OI Plattner, Florian/0000-0002-3150-1866 FU European Community [222918]; U.S. National Institutes of Health [MH090963, DA10044, NS061954, MH79710, MH083711, DA016672, DA033485, NS073855]; [DA0018343] FX This work was supported by the European Community contract number 222918 (REPLACES) FP7-Thematic priority HEALTH to P. C., and U.S. National Institutes of Health grants to P. G. (MH090963 and DA10044), J.D.H. (NS061954), and J.A.B. (MH79710, MH083711, DA016672, DA033485, NS073855). This work was also supported by DA0018343 Pilot Project funding (J.A.B.). We thank W. Lai, X. Li, and M. Kouser, for technical assistance, and F. Gillardon and Boehringer Ingelheim, for indolinone. We thank P. Chambon and Universaire de Srasbourg, for Prp-ERT transgenic mice, and A. Sonneborn, for help with manuscript preparation. NR 44 TC 19 Z9 19 U1 0 U2 6 PU SOC NEUROSCIENCE PI WASHINGTON PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA SN 0270-6474 J9 J NEUROSCI JI J. Neurosci. PD JUN 11 PY 2014 VL 34 IS 24 BP 8259 EP 8267 DI 10.1523/JNEUROSCI.4368-13.2014 PG 9 WC Neurosciences SC Neurosciences & Neurology GA AK3QB UT WOS:000338338700019 PM 24920629 ER PT J AU Wiegert, K Dinh, TH Mushavi, A Mugurungi, O Kilmarx, PH AF Wiegert, Katherine Dinh, Thu-Ha Mushavi, Angela Mugurungi, Owen Kilmarx, Peter H. TI Integration of Prevention of Mother-to-Child Transmission of HIV (PMTCT) Postpartum Services with Other HIV Care and Treatment Services within the Maternal and Child Health Setting in Zimbabwe, 2012 SO PLOS ONE LA English DT Article ID EARLY INFANT DIAGNOSIS; ANTIRETROVIRAL THERAPY; ANTENATAL CARE; METAANALYSIS; MORTALITY; AFRICA AB Background: We assessed the integration of PMTCT services during the postpartum period including early infant diagnosis of HIV (EID) and adult and pediatric antiretroviral therapy (ART) in maternal and child health (MCH) facilities in Zimbabwe Methods and Findings: From August to December 2012 we conducted a cross-sectional survey of a nationally representative sample of 151 MCH facilities. A questionnaire was used to survey each site about staff training, dried blood spot sample (DBS) collection, turnaround time (TAT) for test results, PMTCT services, and HIV care and treatment linkages for HIV-infected mothers and children and HIV-exposed infants. Descriptive analyses were used. Of the facilities surveyed, all facilities were trained on DBS collection and 92% responded. Approximately, 99% of responding facilities reported providing DBS collection and a basic HIV-exposed infant service package including EID, extended nevirapine prophylaxis, and use of cotrimoxazole. DBS collection was integrated with immunisations at 83% of facilities, CD4 testing with point-of-care machines was available at 37% of facilities, and ART for both mothers and children was provided at 27% of facilities. More than 80% of facilities reported that DBS test results take >4 weeks to return; TAT did not have a direct association with any specific type of transport, distance to the lab, or intermediate stops for data to travel. Conclusions: Zimbabwe has successfully scaled up and integrated the national EID and PMTCT programs into the existing MCH setting. The long TAT of infant DBS test results and the lack of integrated ART programs in the MCH setting could reduce effectiveness of the national PMTCT and ART programs. Addressing these important gaps will support successful implementation of the 2014 Zimbabwe's PMTCT guidelines under which all HIV-infected pregnant and breastfeeding women will be offered life-long ART and decentralized ART care. C1 [Wiegert, Katherine] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Wiegert, Katherine] Duke Univ, Med Ctr, Durham, NC USA. [Dinh, Thu-Ha; Kilmarx, Peter H.] US Ctr Dis Control & Prevent, Ctr Global Hlth, Div Global HIV AIDS, Atlanta, GA 30333 USA. [Mushavi, Angela; Mugurungi, Owen] Minist Hlth & Child Care Zimbabwe, AIDS & TB Unit, Harare, Zimbabwe. [Kilmarx, Peter H.] US Ctr Dis Control & Prevent, Ctr Global Hlth, Div Global HIV AIDS, Harare, Zimbabwe. RP Dinh, TH (reprint author), US Ctr Dis Control & Prevent, Ctr Global Hlth, Div Global HIV AIDS, Atlanta, GA 30333 USA. EM dvt1@cdc.gov OI Kilmarx, Peter/0000-0001-6464-3345 FU President's Emergency Plan for AIDS Relief (PEPFAR) [U2GGH00315-01] FX This work was supported by the President's Emergency Plan for AIDS Relief (PEPFAR) under the Cooperative Agreement (U2GGH00315-01) between the Centers for Disease Control and the University of Zimbabwe/Department of Community Medicine. No funding bodies had any role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 19 TC 5 Z9 6 U1 2 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 10 PY 2014 VL 9 IS 6 AR e98236 DI 10.1371/journal.pone.0098236 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AN9SD UT WOS:000340947700017 PM 24915422 ER PT J AU Mack, DG Falta, MT McKee, AS Martin, AK Simonian, PL Crawford, F Gordon, T Mercer, RR Hoover, MD Marrack, P Kappler, JW Tuder, RM Fontenot, AP AF Mack, Douglas G. Falta, Michael T. McKee, Amy S. Martin, Allison K. Simonian, Philip L. Crawford, Frances Gordon, Terry Mercer, Robert R. Hoover, Mark D. Marrack, Philippa Kappler, John W. Tuder, Rubin M. Fontenot, Andrew P. TI Regulatory T cells modulate granulomatous inflammation in an HLA-DP2 transgenic murine model of beryllium-induced disease SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE metal hypersensitivity; MHC presentation; genetic susceptibility ID SUSCEPTIBILITY; TUBERCULOSIS; OXIDE; LUNG AB Susceptibility to chronic beryllium disease (CBD) is linked to certain HLA-DP molecules, including HLA-DP2. To elucidate the molecular basis of this association, we exposed mice transgenic (Tg) for HLA-DP2 to beryllium oxide (BeO) via oropharyngeal aspiration. As opposed to WT mice, BeO-exposed HLA-DP2 Tg mice developed mononuclear infiltrates in a peribronchovascular distribution that were composed of CD4(+) T cells and included regulatory T (T-reg) cells. Beryllium-responsive, HLA-DP2-restricted CD4(+) T cells expressing IFN-gamma and IL-2 were present in BeO-exposed HLA-DP2 Tg mice and not in WT mice. Using Be-loaded HLA-DP2-peptide tetramers, we identified Be-specific CD4(+) T cells in the mouse lung that recognize identical ligands as CD4(+) T cells derived from the human lung. Importantly, a subset of HLA-DP2 tetramer-binding CD4(+) T cells expressed forkhead box P3, consistent with the expansion of antigen-specific T-reg cells. Depletion of T-reg cells in BeO-exposed HLA-DP2 Tg mice exacerbated lung inflammation and enhanced granuloma formation. These findings document, for the first time to our knowledge, the development of a Be-specific adaptive immune response in mice expressing HLA-DP2 and the ability of T-reg cells to modulate the beryllium-induced granulomatous immune response. C1 [Mack, Douglas G.; Falta, Michael T.; McKee, Amy S.; Martin, Allison K.; Simonian, Philip L.; Tuder, Rubin M.; Fontenot, Andrew P.] Univ Colorado, Dept Med, Aurora, CO 80045 USA. [Crawford, Frances; Marrack, Philippa; Kappler, John W.; Fontenot, Andrew P.] Univ Colorado, Dept Immunol, Aurora, CO 80045 USA. [Gordon, Terry] NYU, Dept Environm Med, Tuxedo Pk, NY 10987 USA. [Mercer, Robert R.; Hoover, Mark D.] NIOSH, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. [Crawford, Frances; Marrack, Philippa; Kappler, John W.] Natl Jewish Hlth, Howard Hughes Med Inst, Denver, CO 80206 USA. RP Kappler, JW (reprint author), Univ Colorado, Dept Immunol, Anschutz Med Campus, Aurora, CO 80045 USA. EM kapplerj@njhealth.org; andrew.fontenot@ucdenver.edu FU National Institutes of Health [HL62410, HL111760, ES11810, ES011473, 212-2010-M-35006, DE-FG02-08ER64670] FX The authors thank Lisa Maier for helpful discussions and Ainsley Weston, Sally Tinkle, and Edward Rubin for the generation of the HLA-DP2 Tg mice. This work is supported by the following National Institutes of Health Grants: HL62410, HL111760, and ES11810 (to A. P. F.); and ES011473, 212-2010-M-35006, and DE-FG02-08ER64670 (to T. G.). The findings and conclusions in this report are those of the authors and do not necessarily represent the views of their respective organizations. NR 23 TC 13 Z9 13 U1 1 U2 3 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JUN 10 PY 2014 VL 111 IS 23 BP 8553 EP 8558 DI 10.1073/pnas.1408048111 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AI6IJ UT WOS:000336976000065 PM 24912188 ER PT J AU Tan, KR Katalenich, BL Mace, KE Nambozi, M Taylor, SM Meshnick, SR Wiegand, RE Chalwe, V Filler, SJ Kamuliwo, M Craig, AS AF Tan, Kathrine R. Katalenich, Bonnie L. Mace, Kimberly E. Nambozi, Michael Taylor, Steve M. Meshnick, Steven R. Wiegand, Ryan E. Chalwe, Victor Filler, Scott J. Kamuliwo, Mulakwa Craig, Allen S. TI Efficacy of sulphadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy, Mansa, Zambia SO MALARIA JOURNAL LA English DT Article DE Malaria; Pregnancy; Intermittent-preventive treatment; Sulphadoxine-pyrimethamine ID PLASMODIUM-FALCIPARUM MALARIA; MOLECULAR MARKERS; TREATMENT POLICY; DRUG-RESISTANCE; WOMEN; GHANA; QUEERPAM; OUTCOMES; THERAPY; BENIN AB Background: Intermittent preventive treatment of malaria in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP) decreases adverse effects of malaria during pregnancy. Zambia implemented its IPTp-SP programme in 2003. Emergence of SP-resistant Plasmodium falciparum threatens this strategy. The quintuple mutant haplotype (substitutions in N51I, C59R, S108N in dhfr and A437G and K540E in dhps genes), is associated with SP treatment failure in non-pregnant patients with malaria. This study examined efficacy of IPTp-SP and presence of the quintuple mutant among pregnant women in Mansa, Zambia. Methods: In Mansa, an area with high malaria transmission, HIV-negative pregnant women presenting to two antenatal clinics for the 1st dose of IPTp-SP with asymptomatic parasitaemia were enrolled and microscopy for parasitaemia was done weekly for five weeks. Outcomes were parasitological failure and adequate parasitological response (no parasitaemia during follow-up). Polymerase chain reaction assays were employed to distinguish recrudescence from reinfection, and identify molecular markers of SP resistance. Survival analysis included those who had reinfection and incomplete follow-up (missed at least one follow-up). Results: Of the 109 women included in the study, 58 (53%) completed all follow-up, 34 (31%) had incomplete follow-up, and 17 (16%) were lost to follow-up after day 0. Of those who had complete follow-up, 15 (26%, 95% confidence interval [CI] [16-38]) had parasitological failure. For the 92 women included in the survival analysis, median age was 20 years (interquartile range [IQR] 18-22), median gestational age was 22 weeks (IQR range 20-24), and 57% were primigravid. There was no difference in time to failure in primigravid versus multigravid women. Of the 84 women with complete haplotype data for the aforementioned loci of the dhfr and dhps genes, 53 (63%, 95% CI [50-70]) had quintuple mutants (two with an additional mutation in A581G of dhps). Among women with complete follow-up and quintuple mutants, 22% had parasitological failure versus 0% without (p = 0.44). Conclusions: While underpowered, this study found 26% failure rates of SP given the moderate prevalence of the quintuple mutant haplotype. Despite the presence of resistance, SP retained some efficacy in clearing parasites in pregnant women, and may remain a viable option for IPTp in Zambia. C1 [Tan, Kathrine R.; Mace, Kimberly E.; Wiegand, Ryan E.] US Ctr Dis Control & Prevent, Malaria Branch, Atlanta, GA 30333 USA. [Katalenich, Bonnie L.] Tulane Univ, Sch Med, New Orleans, LA 70112 USA. [Nambozi, Michael] Trop Dis Res Ctr, Ndola, Zambia. [Taylor, Steve M.] Duke Univ, Med Ctr, Durham, NC USA. [Meshnick, Steven R.] Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Chalwe, Victor] Maina Soko Mil Hosp Lusaka, Lusaka, Zambia. [Filler, Scott J.] Global Fund Fight AIDS TB & Malaria, Geneva, Switzerland. [Kamuliwo, Mulakwa] Natl Malaria Control Ctr, Lusaka, Zambia. [Craig, Allen S.] US Ctr Dis Control & Prevent, Vaccine Preventable Dis Eradicat & Eliminat Branc, Atlanta, GA USA. RP Tan, KR (reprint author), US Ctr Dis Control & Prevent, Malaria Branch, Atlanta, GA 30333 USA. EM ktan@cdc.gov FU President's Malaria Initiative FX This study was funded by the President's Malaria Initiative. NR 35 TC 7 Z9 7 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD JUN 9 PY 2014 VL 13 AR 227 DI 10.1186/1475-2875-13-227 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AL1LP UT WOS:000338887200001 PM 24909578 ER PT J AU McCann, RS Messina, JP MacFarlane, DW Bayoh, MN Vulule, JM Gimnig, JE Walker, ED AF McCann, Robert S. Messina, Joseph P. MacFarlane, David W. Bayoh, M. Nabie Vulule, John M. Gimnig, John E. Walker, Edward D. TI Modeling larval malaria vector habitat locations using landscape features and cumulative precipitation measures SO INTERNATIONAL JOURNAL OF HEALTH GEOGRAPHICS LA English DT Article DE Random forest; Logistic regression; Anopheles gambiae; Larval habitats; Predictive models ID GAMBIAE COMPLEX DIPTERA; WESTERN KENYA HIGHLANDS; HIGH-SPATIAL-RESOLUTION; ANOPHELES-GAMBIAE; LAND-COVER; CHILD-MORTALITY; BREEDING HABITATS; CULICIDAE; AFRICA; RISK AB Background: Predictive models of malaria vector larval habitat locations may provide a basis for understanding the spatial determinants of malaria transmission. Methods: We used four landscape variables (topographic wetness index [TWI], soil type, land use-land cover, and distance to stream) and accumulated precipitation to model larval habitat locations in a region of western Kenya through two methods: logistic regression and random forest. Additionally, we used two separate data sets to account for variation in habitat locations across space and over time. Results: Larval habitats were more likely to be present in locations with a lower slope to contributing area ratio (i.e. TWI), closer to streams, with agricultural land use relative to nonagricultural land use, and in friable clay/sandy clay loam soil and firm, silty clay/clay soil relative to friable clay soil. The probability of larval habitat presence increased with increasing accumulated precipitation. The random forest models were more accurate than the logistic regression models, especially when accumulated precipitation was included to account for seasonal differences in precipitation. The most accurate models for the two data sets had area under the curve (AUC) values of 0.864 and 0.871, respectively. TWI, distance to the nearest stream, and precipitation had the greatest mean decrease in Gini impurity criteria in these models. Conclusions: This study demonstrates the usefulness of random forest models for larval malaria vector habitat modeling. TWI and distance to the nearest stream were the two most important landscape variables in these models. Including accumulated precipitation in our models improved the accuracy of larval habitat location predictions by accounting for seasonal variation in the precipitation. Finally, the sampling strategy employed here for model parameterization could serve as a framework for creating predictive larval habitat models to assist in larval control efforts. C1 [McCann, Robert S.] Michigan State Univ, Dept Entomol, E Lansing, MI 48824 USA. [Messina, Joseph P.] Michigan State Univ, Dept Geog, E Lansing, MI 48824 USA. [MacFarlane, David W.] Michigan State Univ, Dept Forestry, E Lansing, MI 48824 USA. [Bayoh, M. Nabie; Vulule, John M.] Ctr Dis Control & Prevent, Kenya Med Res Inst, Ctr Global Hlth Res, Kisumu, Kenya. [Gimnig, John E.] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA USA. [Walker, Edward D.] Michigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA. RP McCann, RS (reprint author), Univ Wageningen & Res Ctr, Entomol Lab, POB 8031, NL-6700 EH Wageningen, Netherlands. EM robert.mccann@wur.nl OI Messina, Joseph/0000-0002-1978-0778; McCann, Robert/0000-0002-2195-6461 NR 48 TC 4 Z9 4 U1 5 U2 17 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1476-072X J9 INT J HEALTH GEOGR JI Int. J. Health Geogr. PD JUN 6 PY 2014 VL 13 AR 17 DI 10.1186/1476-072X-13-17 PG 12 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AK1EF UT WOS:000338157400001 PM 24903736 ER PT J AU Mazurek, JM Syamlal, G King, BA Castellan, RM AF Mazurek, Jacek M. Syamlal, Girija King, Brian A. Castellan, Robert M. TI Smokeless Tobacco Use Among Working Adults - United States, 2005 and 2010 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID PRODUCTS; SMOKERS C1 [Mazurek, Jacek M.; Syamlal, Girija; Castellan, Robert M.] CDC, NIOSH, Div Resp Dis Studies, Atlanta, GA 30333 USA. [King, Brian A.] CDC, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. RP Mazurek, JM (reprint author), CDC, NIOSH, Div Resp Dis Studies, Atlanta, GA 30333 USA. EM acq8@cdc.gov NR 10 TC 19 Z9 19 U1 1 U2 6 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JUN 6 PY 2014 VL 63 IS 22 BP 477 EP 482 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AI5OG UT WOS:000336917800001 PM 24898164 ER PT J AU Epperson, S Blanton, L Kniss, K Mustaquim, D Steffens, C Wallis, T Dhara, R Leon, M Perez, A Chaves, SS Abd Elal, A Gubareva, L Xu, XY Villanueva, J Bresee, J Cox, N Finelli, L Brammer, L AF Epperson, Scott Blanton, Lenee Kniss, Krista Mustaquim, Desiree Steffens, Craig Wallis, Teresa Dhara, Rosaline Leon, Michelle Perez, Alejandro Chaves, Sandra S. Abd Elal, Anwar Gubareva, Larisa Xu, Xiyan Villanueva, Julie Bresee, Joseph Cox, Nancy Finelli, Lyn Brammer, Lynnette TI Influenza Activity - United States, 2013-14 Season and Composition of the 2014-15 Influenza Vaccines SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID VIRUS C1 [Epperson, Scott; Blanton, Lenee; Kniss, Krista; Mustaquim, Desiree; Steffens, Craig; Wallis, Teresa; Dhara, Rosaline; Leon, Michelle; Perez, Alejandro; Chaves, Sandra S.; Abd Elal, Anwar; Gubareva, Larisa; Xu, Xiyan; Villanueva, Julie; Bresee, Joseph; Cox, Nancy; Finelli, Lyn; Brammer, Lynnette] CDC, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Epperson, S (reprint author), CDC, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM sepperson@cdc.gov NR 6 TC 30 Z9 30 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JUN 6 PY 2014 VL 63 IS 22 BP 483 EP 490 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AI5OG UT WOS:000336917800002 PM 24898165 ER PT J AU Hall, AJ Wikswo, ME Pringle, K Gould, LH Parashar, UD AF Hall, Aron J. Wikswo, Mary E. Pringle, Kimberly Gould, L. Hannah Parashar, Umesh D. TI Vital Signs: Foodborne Norovirus Outbreaks - United States, 2009-2012 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID NORWALK VIRUS; GASTROENTERITIS; ILLNESS AB Introduction: Norovirus is the leading cause of acute gastroenteritis and foodborne disease in the United States, causing an estimated one in 15 U. S. residents to become ill each year as well as 56,000-71,000 hospitalizations and 570-800 deaths, predominantly among young children and the elderly. Whereas noroviruses often spread through person-to-person contact, foodborne transmission can cause widespread exposures and presents important prevention opportunities. Methods: CDC analyzed 2009-2012 data on suspected and confirmed norovirus outbreaks reported by state, local, and territorial health departments through the National Outbreak Reporting System (NORS) to characterize the epidemiology of foodborne norovirus outbreaks. Results: During 2009-2012, a total of 1,008 foodborne norovirus outbreaks were reported to NORS, constituting 48% of all foodborne outbreaks with a single known cause. Outbreaks were reported by 43 states and occurred year round. Restaurants were the most common setting (64%) of food preparation reported in outbreaks. Of 520 outbreaks with factors contributing to contamination reported, food workers were implicated as the source in 70%. Of 324 outbreaks with an implicated food, most resulted from food contaminated during preparation (92%) and food consumed raw (75%). Specific food categories were implicated in only 67 outbreaks; the most frequently named were vegetable row crops (e. g., leafy vegetables) (30%), fruits (21%), and mollusks (19%). Conclusions: Noroviruses are the leading cause of reported foodborne disease outbreaks and most often associated with contamination of food in restaurants during preparation by infected food workers. Implications for Public Health Practice: Improved adherence to appropriate hand hygiene, excluding ill staff members from working until >= 48 hours after symptom resolution, and supervision by certified kitchen managers are all recommended to reduce the incidence of foodborne norovirus disease. C1 [Hall, Aron J.; Wikswo, Mary E.; Parashar, Umesh D.] CDC, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Pringle, Kimberly] CDC, EIS, Atlanta, GA 30333 USA. [Gould, L. Hannah] CDC, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Dis, Atlanta, GA 30333 USA. RP Hall, AJ (reprint author), CDC, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM ajhall@cdc.gov NR 17 TC 52 Z9 52 U1 2 U2 34 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JUN 6 PY 2014 VL 63 IS 22 BP 491 EP 495 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AI5OG UT WOS:000336917800003 PM 24898166 ER PT J AU Gastanaduy, PA Redd, SB Fiebelkorn, AP Rota, JS Rota, PA Bellini, WJ Seward, JF Wallace, GS AF Gastanaduy, Paul A. Redd, Susan B. Fiebelkorn, Amy Parker Rota, Jennifer S. Rota, Paul A. Bellini, William J. Seward, Jane F. Wallace, Gregory S. TI Measles - United States, January 1-May 23, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID CHILDREN C1 [Gastanaduy, Paul A.; Redd, Susan B.; Fiebelkorn, Amy Parker; Rota, Jennifer S.; Rota, Paul A.; Bellini, William J.; Seward, Jane F.; Wallace, Gregory S.] CDC, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Gastanaduy, PA (reprint author), CDC, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM pgastanaduy@cdc.gov NR 10 TC 52 Z9 53 U1 0 U2 6 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JUN 6 PY 2014 VL 63 IS 22 BP 496 EP 499 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AI5OG UT WOS:000336917800004 PM 24898167 ER PT J AU Fischer, M Staples, JE AF Fischer, Marc Staples, J. Erin TI Chikungunya Virus Spreads in the Americas - Caribbean and South America, 2013-2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Fischer, Marc; Staples, J. Erin] CDC, Arboviral Dis Branch, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. RP Fischer, M (reprint author), CDC, Arboviral Dis Branch, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. EM mfischer@cdc.gov NR 4 TC 55 Z9 60 U1 1 U2 22 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JUN 6 PY 2014 VL 63 IS 22 BP 500 EP 501 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AI5OG UT WOS:000336917800005 PM 24898168 ER PT J AU Ambuel, Y Young, G Brewoo, JN Paykel, J Weisgrau, KL Rakasz, EG Haller, AA Royals, M Huang, CYH Capuano, S Stinchcomb, DT Partidos, CD Osorio, JE AF Ambuel, Yuping Young, Ginger Brewoo, Joseph N. Paykel, Joanna Weisgrau, Kim L. Rakasz, Eva G. Haller, Aurelia A. Royals, Michael Huang, Claire Y. -H. Capuano, Saverio Stinchcomb, Dan T. Partidos, Charalambos D. Osorio, Jorge E. TI A rapid immunization strategy with a live-attenuated tetravalent dengue vaccine elicits protective neutralizing antibody responses in non-human primates SO FRONTIERS IN IMMUNOLOGY LA English DT Article DE dengue; vaccine; non-human primates; neutralizing antibodies; needle-free delivery; T cell responses ID STRAIN 16681; VIRUS-VACCINE; PDK-53 VIRUS; EFFICACY; DENVAX; PATHOGENESIS; VOLUNTEERS; VIREMIA AB Dengue viruses (DENVs) cause approximately 390 million cases of DENV infections annually and over 3 billion people worldwide are at risk of infection. No dengue vaccine is currently available nor is there an antiviral therapy for DENV infections. We have developed a tetravalent live-attenuated DENV vaccine tetravalent dengue vaccine (TDV) that consists of a molecularly characterized attenuated DENV-2 strain (TDV-2) and three chimeric viruses containing the pre-membrane and envelope genes of DENV-1, -3, and -4 expressed in the context of the TDV-2 genome. To impact dengue vaccine delivery in endemic areas and immunize travelers, a simple and rapid immunization strategy (RIS) is preferred. We investigated RIS consisting of two full vaccine doses being administered subcutaneously or intradermally on the initial vaccination visit (day 0) at two different anatomical locations with a needle-free disposable syringe jet injection delivery devices (PharmaJet) in non-human primates. This vaccination strategy resulted in efficient priming and induction of neutralizing antibody responses to all four DENV serotypes comparable to those elicited by the traditional prime and boost (2 months later) vaccination schedule. In addition, the vaccine induced CD4(+) and CD8(+) T cells producing IFN-gamma, IL-2, and TNF-alpha, and targeting the DENV-2 NS1, NS3, and NS5 proteins. Moreover, vaccine-specific T cells were cross-reactive with the non-structural NS3 and NS5 proteins of DENV-4. When animals were challenged with DENV-2 they were protected with no detectable viremia, and exhibited sterilizing immunity (no increase of neutralizing titers post-challenge). RIS could decrease vaccination visits and provide quick immune response to all four DENV serotypes. This strategy could increase vaccination compliance and would be especially advantageous for travelers into endemic areas. C1 [Ambuel, Yuping; Young, Ginger; Brewoo, Joseph N.; Paykel, Joanna; Partidos, Charalambos D.; Osorio, Jorge E.] Takeda Vaccines Inc, Madison, WI 53719 USA. [Weisgrau, Kim L.; Rakasz, Eva G.; Capuano, Saverio] Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Madison, WI USA. [Haller, Aurelia A.; Stinchcomb, Dan T.] Takeda Vaccines Inc, Ft Collins, CO USA. [Royals, Michael] PharmaJet Inc, Golden, CO USA. [Huang, Claire Y. -H.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA. RP Partidos, CD (reprint author), Takeda Vaccines Inc, 504 S Rosa Rd,Suite 200, Madison, WI 53719 USA. EM harry.partidos@takeda.com OI Royals, Michael/0000-0003-3639-3101; Stinchcomb, Dan/0000-0002-3634-7503 FU Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [HH5N272201000034C] FX This project has been funded in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract No. HH5N272201000034C. NR 27 TC 9 Z9 9 U1 1 U2 3 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-3224 J9 FRONT IMMUNOL JI Front. Immunol. PD JUN 5 PY 2014 VL 5 BP 1 EP 8 AR 263 DI 10.3389/fimmu.2014.00263 PG 8 WC Immunology SC Immunology GA CH8IG UT WOS:000354279200001 PM 24926294 ER PT J AU Jiang, Y Satten, GA Han, YJ Epstein, MP Heinzen, EL Goldstein, DB Allen, AS AF Jiang, Yu Satten, Glen A. Han, Yujun Epstein, Michael P. Heinzen, Erin L. Goldstein, David B. Allen, Andrew S. TI Utilizing Population Controls in Rare-Variant Case-Parent Association Tests SO AMERICAN JOURNAL OF HUMAN GENETICS LA English DT Article ID COMMON DISEASES; SEQUENCING DATA; FRAMEWORK; RISK AB There is great interest in detecting associations between human traits and rare genetic variation. To address the low power implicit in single-locus tests of rare genetic variants, many rare-variant association approaches attempt to accumulate information across a gene, often by taking linear combinations of single-locus contributions to a statistic. Using the right linear combination is key an optimal test will up-weight true causal variants, down-weight neutral variants, and correctly assign the direction of effect for causal variants. Here, we propose a procedure that exploits data from population controls to estimate the linear combination to be used in an case-parent trio rare-variant association test. Specifically, we estimate the linear combination by comparing population control allele frequencies with allele frequencies in the parents of affected offspring: These estimates are then used to construct a rare-variant transmission disequilibrium test (rvTDT) in the case-parent data. Because the rvTDT is conditional on the parents' data, using parental data in estimating the linear combination does not affect the validity or asymptotic distribution of the rvTDT. By using simulation, we show that our new population-control-based rvTDT can dramatically improve power over rvTDTs that do not use population control information across a wide variety of genetic architectures. It also remains valid under population stratification. We apply the approach to a cohort of epileptic encephalopathy (EE) trios and find that dominant (or additive) inherited rare variants are unlikely to play a substantial role within EE genes previously identified through de novo mutation studies. C1 [Jiang, Yu; Allen, Andrew S.] Duke Univ, Dept Biostat & Bioinformat, Durham, NC 27710 USA. [Satten, Glen A.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Han, Yujun; Heinzen, Erin L.; Goldstein, David B.; Allen, Andrew S.] Duke Univ, Ctr Human Genome Variat, Sch Med, Durham, NC 27708 USA. [Epstein, Michael P.] Emory Univ, Dept Human Genet, Sch Med, Atlanta, GA 30322 USA. RP Allen, AS (reprint author), Duke Univ, Dept Biostat & Bioinformat, Durham, NC 27710 USA. EM andrew.s.allen@duke.edu OI Satten, Glen/0000-0001-7275-5371 FU National Institute of Neurological Disorders and Stroke [NS053998, NS077364, NS077274, NS077303, NS077276]; National Human Genome Research Institute [HG007508] FX We thank the patients and investigators of Epi4k and the Epilepsy Phenome/Genome project for access to the epileptic encephalopathy data. This work was supported by grants from the National Institute of Neurological Disorders and Stroke (The Epilepsy Phenome/Genome Project NS053998; Epi4K Project 1 - Epileptic Encephalopathies NS077364; Epi4K - Administrative Core NS077274; Epi4K Sequencing, Biostatistics and Bioinformatics Core NS077303; and Epi4K - Phenotyping and Clinical Informatics Core NS077276). M.P.E. is a consultant for Amnion Laboratories and was also supported by a grant from the National Human Genome Research Institute (HG007508). The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 27 TC 9 Z9 9 U1 1 U2 5 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0002-9297 EI 1537-6605 J9 AM J HUM GENET JI Am. J. Hum. Genet. PD JUN 5 PY 2014 VL 94 IS 6 BP 845 EP 853 DI 10.1016/j.ajhg.2014.04.014 PG 9 WC Genetics & Heredity SC Genetics & Heredity GA AJ0HK UT WOS:000337331200005 PM 24836453 ER PT J AU Fernandes, EG Sato, HK Leshem, E Flannery, B Konstantyner, TCRD Veras, MADM Patel, MM AF Fernandes, Eder Gatti Sato, Helena Keico Leshem, Eyal Flannery, Brendan Roma de Oliveira Konstantyner, Thais Claudia de Sousa Mascena Veras, Maria Amelia Patel, Manish M. TI Impact of rotavirus vaccination on diarrhea-related hospitalizations S(a) over tilde o paulo State, Brazil SO VACCINE LA English DT Article DE Rotavirus; Vaccine; Diarrhea; Brazil ID UNITED-STATES; LATIN-AMERICA; CHILDREN; REDUCTION; MORTALITY; DISEASE AB Introduction: Following introduction of routine infant rotavirus vaccination, severe diarrhea hospitalization rates declined among children aged <5 years throughout Brazil. Ensuring equity of rotavirus vaccine impact is important in countries that self-finance immunization programs. The objective of this study was to examine rotavirus vaccine impact on diarrhea admission rates among children aged <5 years in Brazil's public health system, according to area-based measures of human development in the state of S(a) over tilde o Paulo, Brazil. Methods: Ecological analysis of public health system hospitalization rates for acute gastroenteritis among children aged <5 years in the state of S(a) over tilde o Paulo, Brazil, according to five categories of municipal development based on a modified Human Development Index for municipalities. Acute gastroenteritis hospitalization rates among children aged <5 years after national rotavirus vaccine introduction (2008-2011) were compared to rates in pre-vaccine years (2000-2005) to calculate percent decline in rates (1 - rate ratio) and 95% confidence intervals (Cl) for each municipal development category. Direct hospitalization costs during the two periods were compared. Results: Annual rates declined by 40% (95% CI, 39-42%) from 631 diarrhea hospitalizations per 100,000 person years pre-rotavirus vaccination to 377 per 100,000 post-vaccination among children aged <5 years and 50% (95% CI, 48-52%) from 1009 to 505 per 100,000 among infants. Highest rates were observed in least developed municipalities. Significant declines of 26-52% among children <5 years and 41-63% among infants were observed in all categories of municipal development. Lower diarrhea hospitalization rates resulted in annual savings of approximately 2 million USD for the state of S(a) over tilde o Paulo. Savings in direct hospitalization costs benefitted municipalities in all five categories. Conclusion: The introduction of rotavirus vaccination was associated with substantial reductions of diarrhea-related admissions at all levels of municipal development in S(a) over tilde o Paulo State, Brazil. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Fernandes, Eder Gatti; Roma de Oliveira Konstantyner, Thais Claudia] Secretaria Estado Saude Sao Paulo, Field Epidemiol Training Program Sao Paulo State, BR-01246000 Sao Paulo, Brazil. [Sato, Helena Keico] Sao Paulo State Hlth Dept, Div Immunizat, BR-01246000 Sao Paulo, Brazil. [Leshem, Eyal] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA 30333 USA. [Flannery, Brendan] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [de Sousa Mascena Veras, Maria Amelia] Fac Ciencias Med Santa Casa Sao Paulo, Dept Social Med, BR-01221020 Sao Paulo, Brazil. [Patel, Manish M.] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA. RP Fernandes, EG (reprint author), Secretaria Estado Saude Sao Paulo, Field Epidemiol Training Program Sao Paulo State, Ave Dr Arnaldo,35,6th Floor, BR-01246000 Sao Paulo, Brazil. EM edergatti@hotmail.com.br; hsato@saude.sp.gov.br; wgp9@cdc.gov; bif4@cdc.gov.br; tcroma@saude.sp.gov.br; maria.veras@gmail.com; aul3@cdc.gov NR 23 TC 13 Z9 14 U1 0 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JUN 5 PY 2014 VL 32 IS 27 BP 3402 EP 3408 DI 10.1016/j.vaccine.2014.04.015 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AI8WT UT WOS:000337208400010 PM 24736002 ER PT J AU Kading, RC Biggerstaff, BJ Young, G Komar, N AF Kading, Rebekah C. Biggerstaff, Brad J. Young, Ginger Komar, Nicholas TI Mosquitoes Used to Draw Blood for Arbovirus Viremia Determinations in Small Vertebrates SO PLOS ONE LA English DT Article ID WEST-NILE-VIRUS; EQUINE ENCEPHALITIS-VIRUS; HIGHLANDS J-VIRUS; EXPERIMENTAL-INFECTION; CHICKENS; STRAINS; BIRDS AB Serial samples from the same individuals may be required for certain virological studies, however, some small animals cannot easily be blood-sampled. Therefore, we evaluated the use of Culex quinquefasciatus Say and Aedes albopictus Skuse mosquitoes as "biological syringes'' to draw blood for virus titer determinations in small vertebrates. Groups of chicks (Gallus gallus), hamsters (Mesocricetus auratus), and house sparrows (Passer domesticus) were experimentally infected with West Nile virus (WNV) or Highlands J virus (HJV). In general, good correlation was seen between mosquito-and syringe-derived blood samples at titers >= 5.0 log(10) pfu/mL serum as compared with titers < 5.0 log(10) pfu/mL serum for chicks, hamsters, and sparrows. Ninety-two percent (24/26) of sparrows with virus titers > 10(5) pfu/mL serum had mosquito-and syringe-derived titers within one log of each other. Sparrow viremia profiles generated from single mosquito blood meals and syringe were not significantly different (p > 0.05). This technique is valuable for assessing the roles of small vertebrates in the ecologies of arboviruses, and could be used in applications beyond virology and infectious diseases, when < 10 mu L of whole blood is required. C1 [Kading, Rebekah C.; Biggerstaff, Brad J.; Young, Ginger; Komar, Nicholas] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. RP Kading, RC (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. EM fxk7@cdc.gov RI Kading, Rebekah/E-5633-2017 OI Kading, Rebekah/0000-0002-4996-915X FU Centers for Disease Control and Prevention FX We would like to thank the late Dr. Andrew Spielman for inspiring this work. Animal care was provided by Verna O'Brien, Andrea Peterson, and Dr. Paul Spurlock. Insectary support was provided by Andrea Peterson and Erin Borland. Permission for sparrow capture was provided by Cozy Cow Dairy, Windsor, CO. This project was financially supported by the Centers for Disease Control and Prevention. The findings and conclusions in this report are those of the authors only, and do not necessarily reflect the views of the United States Government. NR 29 TC 3 Z9 3 U1 2 U2 12 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 5 PY 2014 VL 9 IS 6 AR e99342 DI 10.1371/journal.pone.0099342 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AI4NF UT WOS:000336841400120 PM 24901448 ER PT J AU Kourtis, AP Read, JS Jamieson, DJ AF Kourtis, Athena P. Read, Jennifer S. Jamieson, Denise J. TI Pregnancy and Infection SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Review ID SURVEILLANCE NETWORK FOODNET; SIMPLEX-VIRUS HEPATITIS; VARICELLA-ZOSTER VIRUS; INFLUENZA-A H1N1; RISK-FACTORS; PLASMODIUM-FALCIPARUM; MALARIA; WOMEN; LISTERIOSIS; HERPES AB BEFORE THE ADVENT OF ANTIBIOTIC AGENTS, PREGNANCY WAS A RECOGnized risk factor for severe complications of pneumococcal pneumonia, including death. 1 The influenza pandemic of 2009 provided a more recent reminder that certain infections may disproportionately affect pregnant women. Are pregnant women at increased risk for acquiring infections? Are pregnant women with infection at increased risk for severe disease? During pregnancy, several mechanical and pathophysiological changes occur (e. g., a decrease in respiratory volumes and urinary stasis due to an enlarging uterus), and immune adaptations are required to accommodate the fetus. In this article, we review and synthesize new knowledge about the severity of and susceptibility to infections in pregnant women. We focus on the infections for which there is evidence of increased severity or susceptibility during pregnancy that is not fully explained by mechanical or anatomical changes, and we discuss these infections in light of new findings on immunologic changes during pregnancy. C1 [Kourtis, Athena P.; Jamieson, Denise J.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Read, Jennifer S.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. RP Kourtis, AP (reprint author), 4770 Buford Hwy NE,MS F74, Atlanta, GA 30341 USA. FU Intramural CDC HHS [CC999999] NR 70 TC 65 Z9 68 U1 4 U2 25 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD JUN 5 PY 2014 VL 370 IS 23 BP 2211 EP 2218 DI 10.1056/NEJMra1213566 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA AI3AF UT WOS:000336729900009 PM 24897084 ER PT J AU Bharaswadkar, S Kanchar, A Thakur, N Shah, S Patnaik, B Click, ES Kumar, AMV Dewan, PK AF Bharaswadkar, Sandeep Kanchar, Avinash Thakur, Narendra Shah, Shubhangi Patnaik, Brinda Click, Eleanor S. Kumar, Ajay M. V. Dewan, Puneet Kumar TI Tuberculosis Management Practices of Private Practitioners in Pune Municipal Corporation, India SO PLOS ONE LA English DT Article ID DELHI AB Background: Private Practitioners (PP) are the primary source of health care for patients in India. Limited representative information is available on TB management practices of Indian PP or on the efficacy of India's Revised National Tuberculosis Control Programme (RNTCP) to improve the quality of TB management through training of PP. Methods: We conducted a cross-sectional survey of a systematic random sample of PP in one urban area in Western India (Pune, Maharashtra). We presented sample clinical vignettes and determined the proportions of PPs who reported practices consistent with International Standards of TB Care (ISTC). We examined the association between RNTCP training and adherence to ISTC by calculating odds ratios and 95% confidence intervals. Results: Of 3,391 PP practicing allopathic medicine, 249 were interviewed. Of these, 55% had been exposed to RNTCP. For new pulmonary TB patients, 63% (158/249) of provider responses were consistent with ISTC diagnostic practices, and 34% (84/249) of responses were consistent with ISTC treatment practices. However, 48% (120/249) PP also reported use of serological tests for TB diagnosis. In the new TB case vignette, 38% (94/249) PP reported use of at least one second line anti-TB drug in the treatment regimen. RNTCP training was not associated with diagnostic or treatment practices. Conclusion: In Pune, India, despite a decade of training activities by the RNTCP, high proportions of providers resorted to TB serology for diagnosis and second-line anti-TB drug use in new TB patients. Efforts to achieve universal access to quality TB management must account for the low quality of care by PP and the lack of demonstrated effect of current training efforts. C1 [Bharaswadkar, Sandeep; Kanchar, Avinash; Dewan, Puneet Kumar] Off World Hlth Org WHO Representat India, New Delhi, India. [Thakur, Narendra; Shah, Shubhangi] Pune Municipal Corp, Directorate Hlth Serv, Pune, Maharashtra, India. [Patnaik, Brinda] MIMER Med Coll, Dept Community Med, Pune, Maharashtra, India. [Click, Eleanor S.] Ctr Dis Control & Prevent CDC, Div TB Eliminat, Atlanta, GA USA. [Kumar, Ajay M. V.] Int Union TB & Lung Dis, Reg Off Southeast, New Delhi, India. RP Bharaswadkar, S (reprint author), Off World Hlth Org WHO Representat India, New Delhi, India. EM bharaswadkars@rntcp.org FU UNION-WHO-CTD-NTI Operational research Project FX This operational research was funded under UNION-WHO-CTD-NTI Operational research Project 2010-2011. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 15 TC 9 Z9 9 U1 1 U2 5 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 4 PY 2014 VL 9 IS 6 AR e97993 DI 10.1371/journal.pone.0097993 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AK4YO UT WOS:000338430700020 PM 24897374 ER PT J AU Gomez, PP Gutman, J Roman, E Dickerson, A Andre, ZH Youll, S Eckert, E Hamel, MJ AF Gomez, Patricia P. Gutman, Julie Roman, Elaine Dickerson, Aimee Andre, Zandra H. Youll, Susan Eckert, Erin Hamel, Mary J. TI Assessment of the consistency of national-level policies and guidelines for malaria in pregnancy in five African countries SO MALARIA JOURNAL LA English DT Article DE Malaria; Pregnancy; IPTp; SP; ITN; LLIN; Case management AB Background: At least 39 sub-Saharan African countries have policies on preventing malaria in pregnancy (MIP), including use of long-lasting insecticidal nets (LLINs), intermittent preventive treatment with sulphadoxine-pyrimethamine (IPTp-SP) and case management. However, coverage of LLINs and IPTp-SP remains below international targets in most countries. One factor contributing to low coverage may be that MIP policies typically are developed by national malaria control programmes (NMCPs), but are implemented through national reproductive health (RH) programmes. Methods: National-level MIP policies, guidelines, and training documents from NMCPs and RH programmes in Kenya, Mali, Mozambique, mainland Tanzania and Uganda were reviewed to assess whether they reflected WHO guidelines for prevention and treatment of MIP, and how consistent MIP content was across documents from the same country. Documents were compared for adherence to WHO guidance concerning IPTp-SP timing and dose, directly observed therapy, promotion and distribution of LLINs, linkages to HIV programmes and MIP case management. Results: The five countries reviewed had national documents promoting IPTp-SP, LLINs and MIP case management. WHO guidance from 2004 frequently was not reflected: four countries recommended the first dose of IPTp-SP at 20 weeks or later (instead of 16 weeks), and three countries restricted the first and second IPTp-SP doses to specific gestational weeks. Documents from four countries provided conflicting guidance on MIP prevention for HIV-positive women, and none provided complete guidance on management of uncomplicated and severe malaria during pregnancy. In all countries, inconsistencies between NMCPs and RH programmes on the timing or dose of IPTp-SP were documented, as was the mechanism for providing LLINs. Inconsistencies also were found in training documents from NMCPs and RH programmes in a given country. Outdated, inconsistent guidelines have the potential to cause confusion and lead to incorrect practices among health workers who implement MIP programmes, contributing to low coverage of IPTp-SP and LLINs. Conclusions: MIP policies, guidelines and training materials are outdated and/or inconsistent in the countries assessed. Updating and ensuring consistency among national MIP documents is needed, along with re-orientation and supervision of health workers to accelerate implementation of the 2012 WHO Global Malaria Programme policy recommendations for IPTp-SP. C1 [Gomez, Patricia P.; Roman, Elaine; Dickerson, Aimee] Mat & Child Hlth Integrated Program, Baltimore, MD USA. [Gutman, Julie; Hamel, Mary J.] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Atlanta, GA USA. [Youll, Susan; Eckert, Erin] US Agcy Int Dev, Presidents Malaria Initiat, Bur Global Hlth, Washington, DC 20523 USA. [Andre, Zandra H.] Ctr Dis Control & Prevent, Presidents Malaria Initiat, Malaria Branch, Div Parasit Dis & Malaria, Atlanta, GA USA. RP Gomez, PP (reprint author), Mat & Child Hlth Integrated Program, Baltimore, MD USA. EM patricia.gomez@jhpiego.org FU U.S. Agency for International Development (USAID) [GHS-A-00-08-00002-00] FX This manuscript was made possible by the generous support of the American people through the U.S. Agency for International Development (USAID), under the terms of the Leader with Associates Cooperative Agreement GHS-A-00-08-00002-00. The authors would like to thank various experts collaborating on malaria programmes in Kenya, Madagascar, Mainland Tanzania and Uganda for their responses to questions about MIP in their countries. NR 18 TC 9 Z9 9 U1 0 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD JUN 3 PY 2014 VL 13 AR 212 DI 10.1186/1475-2875-13-212 PG 13 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AL1PL UT WOS:000338897300001 PM 24888703 ER PT J AU Andrade, AL Ternes, YM Vieira, MA Moreira, WG Lamaro-Cardoso, J Kipnis, A Cardoso, MR Brandileone, MC Moura, I Pimenta, FC Carvalho, MD Saraiva, FO Toscano, CM Minamisava, R AF Andrade, Ana Lucia Ternes, Yves Mauro Vieira, Maria Aparecida Moreira, Weslley Garcia Lamaro-Cardoso, Juliana Kipnis, Andre Cardoso, Maria Regina Brandileone, Maria Cristina Moura, Iaci Pimenta, Fabiana C. Carvalho, Maria da Gloria Saraiva, Fabricia Oliveira Toscano, Cristiana Maria Minamisava, Ruth TI Direct Effect of 10-Valent Conjugate Pneumococcal Vaccination on Pneumococcal Carriage in Children Brazil SO PLOS ONE LA English DT Article ID STREPTOCOCCUS-PNEUMONIAE; NASOPHARYNGEAL CARRIAGE; YOUNG-CHILDREN; IMPACT; DISEASE; COLONIZATION; EFFICACY; VACCINES; PROGRAM AB Background: 10-valent conjugate pneumococcal vaccine/PCV10 was introduced in the Brazilian National Immunization Program along the year of 2010. We assessed the direct effectiveness of PCV10 vaccination in preventing nasopharyngeal/NP pneumococcal carriage in infants. Methods: A cross-sectional population-based household survey was conducted in Goiania Brazil, from December/2010-February/2011 targeting children aged 7-11 m and 15-18 m. Participants were selected using a systematic sampling. NP swabs, demographic data, and vaccination status were collected from 1,287 children during home visits. Main outcome and exposure of interest were PCV10 vaccine-type carriage and dosing schedules (3p+0, 2p+0, and one catch-up dose), respectively. Pneumococcal carriage was defined by a positive culture and serotyping was performed by Quellung reaction. Rate ratio/RR was calculated as the ratio between the prevalence of vaccine-types carriage in children exposed to different schedules and unvaccinated for PCV10. Adjusted RR was estimated using Poisson regression. PCV10 effectiveness/VE on vaccine-type carriage was calculated as 1-RR*100. Results: The prevalence of pneumococcal carriage was 41.0% (95% CI: 38.4-43.7). Serotypes covered by PCV10 and PCV13 were 35.2% and 53.0%, respectively. Vaccine serotypes 6B (11.6%), 23F (7.8%), 14 (6.8%), and 19F (6.6%) were the most frequently observed. After adjusted for confounders, children who had received 2p+0 or 3p+0 dosing schedule presented a significant reduction in pneumococcal vaccine-type carriage, with PCV10 VE equal to 35.9% (95% CI: 4.2-57.1; p = 0.030) and 44.0% (95% CI: 14.-63.5; p = 0.008), respectively, when compared with unvaccinated children. For children who received one catch-up dose, no significant VE was detected (p = 0.905). Conclusion: PCV10 was associated with high protection against vaccine-type carriage with 2p+0 and 3p+0 doses for children vaccinated before the second semester of life. The continuous evaluation of carriage serotypes distribution is likely to be useful for evaluating the long-term effectiveness and impact of pneumococcal vaccination on serotypes reduction. C1 [Andrade, Ana Lucia; Ternes, Yves Mauro; Moreira, Weslley Garcia; Saraiva, Fabricia Oliveira; Toscano, Cristiana Maria] Univ Fed Goias, Inst Trop Pathol & Publ Hlth, Goiania, Go, Brazil. [Ternes, Yves Mauro] Secretariat Hlth Municipal Goiania, Epidemiol Branch, Goiania, Go, Brazil. [Vieira, Maria Aparecida] Pontifical Catholic Univ Goias, Goiania, Go, Brazil. [Moreira, Weslley Garcia; Lamaro-Cardoso, Juliana; Kipnis, Andre] Univ Fed Goias, Bacteriol Lab, Goiania, Go, Brazil. [Cardoso, Maria Regina] Univ Sao Paulo, Sch Publ Hlth, Dept Epidemiol, Sao Paulo, Brazil. [Brandileone, Maria Cristina] Adolfo Lutz Inst, Sao Paulo, Brazil. [Moura, Iaci; Pimenta, Fabiana C.; Carvalho, Maria da Gloria] Ctr Dis Control & Prevent, Resp Dis Branch, Atlanta, GA USA. [Minamisava, Ruth] Univ Fed Goias, Fac Nursing, Goiania, Go, Brazil. RP Andrade, AL (reprint author), Univ Fed Goias, Inst Trop Pathol & Publ Hlth, Goiania, Go, Brazil. EM alssandrade@gmail.com RI Andrade, Ana Lucia/L-5751-2013; OI Minamisava, Ruth/0000-0001-9352-5567 FU National Council for Scientific and Technological Development (CNPq); National Institute of Science and Technology for Health (IATS) [573826/2008-0, 306096/2010-2]; Research Foundation of the Goias State/ FAPEG-GO, Brazil [PRONEX/07-2009]; Foundation for Research Support/ FUNAPE-GO, Federal University of Goias [34131]; Fogarty International Center Global Infectious Diseases Research Training Program; National Institutes of Health [D43TW006592] FX Funding provided by National Council for Scientific and Technological Development (CNPq) and National Institute of Science and Technology for Health (IATS) (#573826/2008-0; 306096/2010-2); Research Foundation of the Goias State/ FAPEG-GO, Brazil (Grant: PRONEX/07-2009); Foundation for Research Support/ FUNAPE-GO, Federal University of Goias (#34131). This work was supported in part by a Fogarty International Center Global Infectious Diseases Research Training Program grant, National Institutes of Health, to the University of Pittsburgh (D43TW006592). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 46 TC 11 Z9 11 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 3 PY 2014 VL 9 IS 6 AR e98128 DI 10.1371/journal.pone.0098128 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AI5ML UT WOS:000336911400036 PM 24892409 ER PT J AU Shakoor, S Kabir, F Khowaja, AR Qureshi, SM Jehan, F Qamar, F Whitney, CG Zaidi, AKM AF Shakoor, Sadia Kabir, Furqan Khowaja, Asif R. Qureshi, Shahida M. Jehan, Fyezah Qamar, Farah Whitney, Cynthia G. Zaidi, Anita K. M. TI Pneumococcal Serotypes and Serogroups Causing Invasive Disease in Pakistan, 2005-2013 SO PLOS ONE LA English DT Article ID DETERMINING CAPSULAR SEROTYPES; SEQUENTIAL MULTIPLEX PCR; STREPTOCOCCUS-PNEUMONIAE; CONJUGATE VACCINE; CHILDREN; SURVEILLANCE; MENINGITIS AB While pneumococcal conjugate vaccines have been implemented in most countries worldwide, use in Asia has lagged in part because of a lack of data on the amount of disease that is vaccine preventable in the region. We describe pneumococcal serotypes elicited from 111 episodes of invasive pneumococcal disease (IPD) from 2005 to 2013 among children and adults in Pakistan. Seventy-three percent (n = 81) of 111 IPD episodes were cases of meningitis (n = 76 in children 0-15 years and n = 5 among adults). Serotypes were determined by target amplification of DNA extracted from pneumococcal isolates (n = 52) or CSF specimens (n = 59). Serogroup 18 was the most common serogroup causing meningitis in children <5 years, accounting for 21% of cases (n = 13). The 10-valent pneumococcal conjugate vaccine (PCV 10) or PCV10- related serotypes were found in 61% (n = 47) of childhood (age 0-15 years) meningitis episodes. PCV-13 increased this coverage to 63% (one additional serotype 19A; n = 48). Our data indicate that use of PCVs would prevent a large proportion of serious pneumococcal disease. C1 [Shakoor, Sadia; Kabir, Furqan; Khowaja, Asif R.; Qureshi, Shahida M.; Jehan, Fyezah; Qamar, Farah; Zaidi, Anita K. M.] Aga Khan Univ Hosp, Dept Pediat & Child Hlth, Karachi, Pakistan. [Shakoor, Sadia] Aga Khan Univ Hosp, Dept Pathol & Microbiol, Karachi, Pakistan. [Whitney, Cynthia G.] CDC, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Zaidi, AKM (reprint author), Aga Khan Univ Hosp, Dept Pediat & Child Hlth, Karachi, Pakistan. EM anita.zaidi@aku.edu FU Johns Hopkins University [PO2000273560]; National Institute of Health's Fogarty International Center [1 D43 TW007585-01] FX Collection of CSF samples used in the study was done through the Johns-Hopkins and GAVI collaboration for the study: Impact of Introduction of HiB Vaccine in selected districts of Pakistan. Grant No. PO2000273560 Johns Hopkins University. Dr. Sadia Shakoor received research training support from the National Institute of Health's Fogarty International Center (1 D43 TW007585-01). The funders of this primary study had no role in study design, data collection and analysis, decision to publish, or preparation of this manuscript. NR 23 TC 3 Z9 3 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 3 PY 2014 VL 9 IS 6 AR e98796 DI 10.1371/journal.pone.0098796 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AI5ML UT WOS:000336911400092 PM 24892937 ER PT J AU Greenwald, R Bergin, MH Yip, F Boehmer, T Kewada, P Shafer, MM Schauer, JJ Sarnat, JA AF Greenwald, Roby Bergin, Michael H. Yip, Fuyuen Boehmer, Tegan Kewada, Priya Shafer, Martin M. Schauer, James J. Sarnat, Jeremy A. TI On-Roadway In-Cabin Exposure to Particulate Matter: Measurement Results Using Both Continuous and Time-Integrated Sampling Approaches SO AEROSOL SCIENCE AND TECHNOLOGY LA English DT Article ID POLYCYCLIC AROMATIC-HYDROCARBONS; ACUTE MYOCARDIAL-INFARCTION; SOLUBLE ORGANIC-CARBON; HEART-RATE-VARIABILITY; URBAN AIR-POLLUTION; LOS-ANGELES; ULTRAFINE PARTICLES; COMPOSITION DISTRIBUTIONS; ELEMENTAL CARBON; OXIDATIVE DAMAGE AB The Atlanta Commuters Exposure (ACE) Study was designed to measure in-cabin exposure to roadway particulate pollution and acute health response in a panel of adults with and without asthma following a 2-h scripted route along major highways in Atlanta. This article focuses on methods and results of both continuous and integrated approaches used to measure the concentration of PM2.5 mass, particle number concentration (PNC), black carbon (BC) mass, and particle-bound PAHs, in-cabin noise, PM elemental composition, elemental carbon, organic carbon, water-soluble organic carbon (WSOC) content, and speciation of a broad range of organic compounds including alkanes, hopanes, and PAHs. Speciated PM data indicates that in-cabin particles derive from three non-co-varying processes: the resuspension of road dust containing crustal elements and previously-deposited brake pad residue with a contribution of normal fuel combustion, incomplete combustion processes producing PAHs and carbon particles, and particles ablated from brake pads that have not previously deposited to the roadside environment. Most in-cabin pollutants were elevated during the warm season with the notable exception of PNC. PNC was not found to be correlated with most other pollutants. In-cabin concentrations were marginally higher when windows were open. Copyright 2014 American Association for Aerosol Research C1 [Greenwald, Roby; Kewada, Priya; Sarnat, Jeremy A.] Emory Univ, Rollins Sch Publ Hlth, Dept Environm Hlth, Atlanta, GA 30322 USA. [Bergin, Michael H.] Georgia Inst Technol, Dept Civil & Environm Engn, Atlanta, GA 30332 USA. [Yip, Fuyuen; Boehmer, Tegan] Ctr Dis Control & Prevent, Air Pollut & Resp Hlth Branch, Atlanta, GA USA. [Shafer, Martin M.; Schauer, James J.] Univ Wisconsin, Environm Chem & Technol Program, Madison, WI USA. RP Greenwald, R (reprint author), Emory Univ, Rollins Sch Publ Hlth, Dept Environm Hlth, 1518 Clifton Rd NE, Atlanta, GA 30322 USA. EM roby.greenwald@emory.edu FU Centers for Disease Control and Prevention; US EPA [R834799] FX This study was made possible in part by funding from the Centers for Disease Control and Prevention. The findings and conclusions in this report are those of the author(s) and do not necessarily represent the views of Centers for Disease Control and Prevention.; This publication was made possible in part by US EPA grant R834799. This publication's contents are solely the responsibility of the grantee and do not necessarily represent the official views of the US EPA. Further, the US EPA does not endorse the purchase of any commercial products or services mentioned in the publication. NR 72 TC 4 Z9 4 U1 6 U2 57 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 520 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0278-6826 EI 1521-7388 J9 AEROSOL SCI TECH JI Aerosol Sci. Technol. PD JUN 3 PY 2014 VL 48 IS 6 BP 664 EP 675 DI 10.1080/02786826.2014.912745 PG 12 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA AH1DQ UT WOS:000335860400004 ER PT J AU Abad, N Baack, B O'Leary, A Lyles, C AF Abad, Neetu Baack, Brittney O'Leary, Ann Lyles, Cynthia TI A REVIEW OF HIV/STD BEHAVIORAL PREVENTION INTERVENTIONS FOR FEMALE SEX WORKERS IN THE UNITED STATES SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Abad, Neetu; Baack, Brittney; Lyles, Cynthia] Ctr Dis Control & Prevent, Atlanta, GA USA. [O'Leary, Ann] Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Prevent Res Branch, Div HIV AIDS Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 70 BP S114 EP S114 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500403 ER PT J AU Alfonso, M Flemming, T Coursey, J Furness, B AF Alfonso, Maria Flemming, Toni Coursey, John Furness, Bruce TI ADDRESSING ANOTHER SILENT EPIDEMIC: HEPATITIS C SCREENING IN A SEXUALLY TRANSMITTED DISEASES CLINIC SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Alfonso, Maria] DC Deparment Hlth, Washington, DC USA. [Flemming, Toni; Furness, Bruce] Ctr Dis Control & Prevent, DSTDP, Washington, DC USA. [Coursey, John] DC Dept Hlth, Washington, DC USA. EM maria.alfonso@dc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 89 BP S63 EP S63 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500216 ER PT J AU Althaus, CL Mishra, S Spicknall, I AF Althaus, Christian L. Mishra, Sharmistha Spicknall, Ian TI MATHEMATICAL MODELING OF RISK BEHAVIORS, TRANSMISSION DYNAMICS AND INTERVENTION IMPACT AND COST SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Althaus, Christian L.] Univ Bern, Inst Social & Prevent Med ISPM, Bern, Switzerland. [Mishra, Sharmistha] Timmins & Dist Hosp, Timmins, ON, Canada. [Spicknall, Ian] Ctr Dis Control & Prevent, DSTP, Hlth Serv Res & Evaluat Branch, Atlanta, GA USA. RI Althaus, Christian/F-6008-2015 OI Althaus, Christian/0000-0002-5230-6760 NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA 1E BP S10 EP S10 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500034 ER PT J AU Asbel, L Anschuetz, G Salmon, M Lewis, F Johnson, C AF Asbel, Lenore Anschuetz, Greta Salmon, Melinda Lewis, Felicia Johnson, Caroline TI SYPHILIS PARTNER SERVICES - CASE FINDING FOR HIV AND OTHER STDS SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Asbel, Lenore; Anschuetz, Greta; Salmon, Melinda; Lewis, Felicia; Johnson, Caroline] Philadelphia Dept Publ Hlth, Philadelphia, PA USA. [Lewis, Felicia] Ctr Dis Control & Prevent, Philadelphia, PA USA. EM greta.anschuetz@phila.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 141 BP S133 EP S133 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500474 ER PT J AU Asbel, L Anschuetz, G Newbern, EC Salmon, M Lewis, F Johnson, C AF Asbel, Lenore Anschuetz, Greta Newbern, E. Claire Salmon, Melinda Lewis, Felicia Johnson, Caroline TI HIV SERODISCORDANT PARTNERSHIPS AMONG MSM DIAGNOSED WITH EARLY SYPHILIS IN PHILADELPHIA SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Asbel, Lenore; Anschuetz, Greta; Newbern, E. Claire; Salmon, Melinda; Lewis, Felicia; Johnson, Caroline] Philadelphia Dept Publ Hlth, Philadelphia, PA USA. [Lewis, Felicia] Ctr Dis Control & Prevent, Philadelphia, PA USA. EM greta.anschuetz@phila.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 24 BP S102 EP S102 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500357 ER PT J AU Beltrami, J Felton, C Castellanos, T Duncan, T Dunbar, E AF Beltrami, John Felton, Chandra Castellanos, Ted Duncan, Ted Dunbar, Erica TI STATUS UPDATE ON CDC-FUNDED PS 12-1201 CATEGORY C DEMONSTRATION PROJECTS: HIV TESTING, LINKAGE TO CARE, AND PARTNER SERVICES SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Beltrami, John; Felton, Chandra; Castellanos, Ted; Duncan, Ted; Dunbar, Erica] CDC, Atlanta, GA 30333 USA. EM hzb3@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 1 BP S96 EP S96 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500334 ER PT J AU Blank, S Seyoum, S Braunstein, S Pathela, P Nash, D Schillinger, J AF Blank, Susan Seyoum, Selam Braunstein, Sarah Pathela, Preeti Nash, Denis Schillinger, Julia TI IMPROVING HIV CARE OUTCOMES AMONG PERSONS NEWLY DIAGNOSED WITH HIV IN THE NEW YORK CITY DEPARTMENT OF HEALTH & MENTAL HYGIENE SEXUALLY TRANSMITTED DISEASE CLINICS, 2010 & 2011 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Blank, Susan; Braunstein, Sarah; Pathela, Preeti] New York City Dept Hlth & Mental Hyg, Long Isl City, NY USA. [Seyoum, Selam] Queens, New York City Dept Hlth & Mental Hyg, Bur HIV, New York, NY USA. [Nash, Denis] CUNY, Sch Publ Hlth Hunter, New York, NY USA. [Schillinger, Julia] Ctr Dis Control & Prevent, Queens, Div Sexually Transmitted Dis Prevent, Hyattsville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA 2F2 BP S16 EP S16 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500054 ER PT J AU Blank, S Borges, C Pathela, P Braunstein, S Shepard, C Schillinger, J AF Blank, Susan Borges, Christine Pathela, Preeti Braunstein, Sarah Shepard, Colin Schillinger, Julia TI FINDING ACUTE HIV INFECTION AT NEW YORK CITY DEPARTMENT OF HEALTH AND MENTAL HYGIENE'S SEXUALLY TRANSMITTED DISEASE CLINICS, 2010-2012 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Blank, Susan; Pathela, Preeti; Braunstein, Sarah] New York City Dept Hlth & Mental Hyg, Long Isl City, NY USA. [Borges, Christine] Dept Hlth & Mental Hyg, Long Isl City, NY USA. [Shepard, Colin] New York City Dept Hlth & Mental Hyg, New York, NY USA. [Schillinger, Julia] Ctr Dis Control & Prevent, Div Sexually Transmitted Dis Prevent, Queens, Hyattsville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA 2C4 BP S14 EP S15 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500049 ER PT J AU Bolan, G Blanchard, J AF Bolan, Gail Blanchard, James TI PROGRAM SCIENCE SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Bolan, Gail] Ctr Dis Control & Prevent, Atlanta, GA USA. [Blanchard, James] Univ Manitoba, Winnipeg, MB, Canada. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA P1 BP S1 EP S1 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500002 ER PT J AU Branson, B Peeling, RW Catania, J AF Branson, Bernard Peeling, Rosanna W. Catania, Joseph TI POINT OF CARE TESTS SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Branson, Bernard] Ctr Dis Control & Prevent, Off Director, Div HIV AIDS Prevent, Atlanta, GA USA. [Peeling, Rosanna W.] London Sch Hyg & Trop Med, Dept Clin Res, London WC1, England. [Catania, Joseph] Oregon State Univ, Coll Publ Hlth & Human Sci, Corvallis, OR 97331 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA 6D BP S39 EP S39 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500126 ER PT J AU Brookmeyer, K AF Brookmeyer, Kathryn TI VIOLENCE EXPOSURE, STD AND SEXUAL HEALTH RISK OUTCOMES: A NATIONALLY REPRESENTATIVE STUDY FROM KENYA SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Brookmeyer, Kathryn] Ctr Dis Control & Prevent, Atlanta, GA USA. EM guul@cdc.gov NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 179 BP S87 EP S88 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500306 ER PT J AU Carrasco, S Gorbach, P Bhagwat, P Parrish, A Collins, T Grauer, B Bolan, R Zimmerman, M Markowitz, L Kerndt, P Meites, E AF Carrasco, Steven Gorbach, Pamina Bhagwat, Priya Parrish, Adam Collins, Tom Gratzer, Beau Bolan, Robert Zimmerman, Michael Markowitz, Lauri Kerndt, Peter Meites, Elissa TI HEALTH SYSTEM BARRIERS TO HUMAN PAPILLOMAVIRUS VACCINATION AMONG YOUNG MEN WHO HAVE SEX WITH MEN IN TWO US CITIES SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Carrasco, Steven; Gorbach, Pamina; Bhagwat, Priya] Univ Calif Los Angeles, Los Angeles, CA USA. [Parrish, Adam; Collins, Tom] Univ Kentucky, Coll Publ Hlth, Lexington, KY 40506 USA. [Gratzer, Beau] Howard Brown Hlth Ctr, Chicago, IL USA. [Bolan, Robert] Los Angeles Gay & Lesbian Ctr, Los Angeles, CA USA. [Zimmerman, Michael] AIDS Healthcare Fdn, Los Angeles, CA USA. [Markowitz, Lauri; Meites, Elissa] Ctr Dis Control & Prevent Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. [Kerndt, Peter] Los Angeles Cty Dept Publ Hlth, Los Angeles, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 29 BP S103 EP S103 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500362 ER PT J AU Carroll, S Kirkcaldy, R Fox, J Kubin, G Trees, D AF Carroll, Serena Kirkcaldy, Robert Fox, Jan Kubin, Grace Trees, David TI DECREASED SUSCEPTIBILITY TO CEFTRIAXONE IN NEISSERIA GONORRHOEAE IN THE ABSENCE OF A MOSAIC PENICILLIN-BINDING PROTEIN 2 (PENA) ALLELE SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Carroll, Serena; Kirkcaldy, Robert; Trees, David] Ctr Dis Control & Prevent, Atlanta, GA USA. [Fox, Jan] Oklahoma Dept Hlth, Oklahoma City, OK USA. [Kubin, Grace] Texas Dept State Hlth Serv, Austin, TX USA. EM scarroll@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 145 BP S78 EP S78 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500272 ER PT J AU Charles, A Michel, E Friedman, A Jackson, P AF Charles, Abby Michel, Elisabeth Friedman, Allison Jackson, Phronie TI SEX PACT: EVALUATION OF AN INNOVATIVE APPROACH TO SEXUAL HEALTH PROMOTION AMONG YOUNG AFRICAN AMERICAN MALES SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Charles, Abby; Michel, Elisabeth] Inst Publ Hlth Informat, Washington, DC USA. [Friedman, Allison] CDC, NCHHSTP, Atlanta, GA 30333 USA. [Jackson, Phronie] Natl Council Negro Women, Washington, DC USA. EM acharles@institutephi.org NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 59 BP S55 EP S55 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500186 ER PT J AU Charles, A Michel, E Friedman, A AF Charles, Abby Michel, Elisabeth Friedman, Allison TI EXPLORING THE REALITIES OF YOUNG AFRICAN AMERICAN MEN TO INFORM SEXUAL HEALTH COMMUNICATION EFFORTS: FINDINGS FROM QUALITATIVE RESEARCH IN WASHINGTON, D.C SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Charles, Abby; Michel, Elisabeth] Inst Publ Hlth Informat, Washington, DC USA. [Friedman, Allison] CDC, NCHHSTP, Atlanta, GA 30333 USA. EM acharles@institutephi.org NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 61 BP S56 EP S56 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500188 ER PT J AU Chen, CY Gaydos, C Grad, Y Unemo, M AF Chen, Cheng Y. Gaydos, Charlotte Grad, Yonatan Unemo, Magnus TI ADVANCES IN MOLECULAR DIAGNOSTICS AND GENOMICS OF AMR SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Chen, Cheng Y.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Gaydos, Charlotte] Johns Hopkins Univ, Dept Med, Div Infect Dis, Baltimore, MD USA. [Grad, Yonatan] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. [Unemo, Magnus] Natl Reference Lab Pathogen Neisscria, Orebro, Sweden. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA 1D BP S10 EP S10 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500033 ER PT J AU Chesson, H Markowitz, L Dunne, E AF Chesson, Harrell Markowitz, Lauri Dunne, Eileen TI THE ESTIMATED IMPACT OF HPV VACCINATION COVERAGE ON LIFETIME CERVICAL CANCER CASES AMONG GIRLS CURRENTLY AGED 12 YEARS AND YOUNGER IN THE UNITED STATES SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Chesson, Harrell; Dunne, Eileen] Ctr Dis Control & Prevent, Atlanta, GA USA. [Markowitz, Lauri] Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. EM hbc7@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 46 BP S52 EP S52 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500173 ER PT J AU Choden, T Hennessy, R Schillinger, J AF Choden, Tsering Hennessy, Robin Schillinger, Julia TI THE FEASIBILITY OF USING HIV INFECTION AS THE SOLE CRITERION FOR INITIATING FIELD INVESTIGATIONS AMONG PERSONS WITH REACTIVE SEROLOGIC TESTS FOR SYPHILIS, NEW YORK CITY, 2012 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Choden, Tsering; Hennessy, Robin] New York City Dept Hlth & Mental Hyg, Queens, NY USA. [Schillinger, Julia] Ctr Dis Control & Prevent, Div Sexually Transmitted Dis Prevent, Queens, NY USA. EM tchoden@health.nyc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 11 BP S98 EP S98 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500344 ER PT J AU Collins, C Younge, S Sales, J DiClemente, R AF Collins, Carmen Younge, Sinead Sales, Jessica DiClemente, Ralph TI EDUCATION, POWER, AND SEX: A QUALITATIVE STUDY ON THE INTERRELATIONSHIP OF FACTORS THAT INFLUENCE THE SEXUAL BEHAVIOR OF AFRICAN AMERICAN WOMEN ATTENDING A HISTORICALLY BLACK COLLEGE SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Collins, Carmen] CDC, Decatur, GA USA. [Younge, Sinead] Morehouse Coll, Atlanta, GA USA. [Sales, Jessica] Emory Univ, Atlanta, GA 30322 USA. [DiClemente, Ralph] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 74 BP S115 EP S115 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500407 ER PT J AU Crain, C Johnson, D Tashima, N Valentine, J AF Crain, Cathleen Johnson, David Tashima, Nathaniel Valentine, Jo TI HEALTHY RELATIONSHIPS: CURRICULA FOR HISTORICALLY BLACK COLLEGE AND UNIVERSITY STUDENTS SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Crain, Cathleen] LTG & Associates Inc, Takoma Pk, MD USA. [Johnson, David] Ctr Dis Control & Prevent, Atlanta, GA USA. [Tashima, Nathaniel] LTG Associates Inc, Turlock, CA USA. [Valentine, Jo] Ctr Dis Control & Prevent, Div STD Prevent, NCHHSTP, Atlanta, GA USA. EM partners@ltgassociates.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 40 BP S50 EP S50 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500167 ER PT J AU Cramer, R Leichliter, J Chesson, H AF Cramer, Ryan Leichliter, Jami Chesson, Harrell TI AN ASSESSMENT OF THE CHARACTERISTICS OF STATE LAWS CONCERNING DISEASE INTERVENTION ACTIVITIES SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Cramer, Ryan; Leichliter, Jami; Chesson, Harrell] Ctr Dis Control & Prevent, Atlanta, GA USA. EM rcramer@cdc.gov NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 113 BP S126 EP S126 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500446 ER PT J AU Dlouhy, D AF Dlouhy, Diane TI DEVELOPMENT OF A STD COMMUNICATIONS TOOLKIT FOR PIOS/COMMUNICATORS IN LOCAL AND STATE HEALTH DEPARTMENTS SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Dlouhy, Diane] CDC, Div STD Prevent, Atlanta, GA 30333 USA. EM IQU0@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 195 BP S92 EP S92 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500322 ER PT J AU Dumitru, G AF Dumitru, Gema TI RECENT FEDERAL GUIDANCE ABOUT SERVICES FOR PERSONS WITH HIV: IMPLICATIONS FOR ACCESS TO STD PREVENTION AND CARE SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Dumitru, Gema] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 85 BP S118 EP S118 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500418 ER PT J AU Evans, L Lawler, K Moore, A Bradford, J AF Evans, Leigh Lawler, Kelsey Moore, Andrea Bradford, Judith TI BARRIERS TO IMPLEMENTING A RISK-REDUCTION PLAN AMONG MSM PARTICIPATING IN A SINGLE-SESSION HIV PREVENTION INTERVENTION SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Evans, Leigh; Lawler, Kelsey; Bradford, Judith] Fenway Hlth, Boston, MA USA. [Moore, Andrea] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 34 BP S105 EP S105 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500367 ER PT J AU Evans, L Lawler, K Moore, A Bradford, J AF Evans, Leigh Lawler, Kelsey Moore, Andrea Bradford, Judith TI MOVING FROM 2-SESSION TO 1-SESSION SEXUAL RISK-REDUCTION COUNSELING: IMPLICATIONS FOR HIGHER-IMPACT HIV PREVENTION AMONG MSM SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Evans, Leigh; Lawler, Kelsey; Bradford, Judith] Fenway Hlth, Boston, MA USA. [Moore, Andrea] Ctr Dis Control & Prevent, Atlanta, GA USA. EM levans@fenwayhealth.org NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 38 BP S49 EP S50 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500165 ER PT J AU Fakile, Y Lupoli, K AF Fakile, Yetunde Lupoli, Kathryn TI ESTABLISHING A QUALITY ASSURANCE PROGRAM FOR SYPHILIS SEROLOGY SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Fakile, Yetunde] Ctr Dis Control & Prevent, NCHHSTP, DSTDP, Atlanta, GA USA. [Lupoli, Kathryn] Ctr Dis Control & Prevent, Atlanta, GA USA. EM yfakile@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP136 BP S76 EP S76 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500263 ER PT J AU Fanfair, RN Fine, D Grier, L Salomon, S Nakarsukasa-Ono, W Blackburn, P Torrone, E Markowitz, L AF Fanfair, Robyn Neblett Fine, David Grier, LaZetta Salomon, Sarah Nakarsukasa-Ono, Wendy Blackburn, Patricia Torrone, Elizabeth Markowitz, Lauri TI EVALUATING DIFFERENCES IN CHLAMYDIA SCREENING AMONG OLDER WOMEN ATTENDING FAMILY PLANNING (FP) CLINICS BY US PUBLIC HEALTH SERVICE (USPHS) REGION, 2010 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Fanfair, Robyn Neblett] CDC, Atlanta, GA 30333 USA. Cardea Serv, Seattle, WA USA. CDC, DHHS, OID, NCHHSTP,DSTDP,SDMB, Atlanta, GA 30333 USA. Cardea, Oakland, CA USA. Ctr Dis Control & Prevent, Atlanta, GA USA. Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. EM iyo5@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 5 BP S41 EP S41 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500132 ER PT J AU Fine, D Salomon, S Bowen, V Hughes, G AF Fine, David Salomon, Sarah Bowen, Virginia Hughes, Gwenda TI MEASURING PROGRAM EFFECTIVENESS: SCREENING COVERAGE, TREATMENT, AND PARTNER SERVICES SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Fine, David; Salomon, Sarah] Cardea Serv, Seattle, WA USA. [Bowen, Virginia] Ctr Dis Control & Prevent, Epidemiol & Stat Branch, Div STD Prevent, Atlanta, GA USA. [Hughes, Gwenda] Publ Hlth England, HIV & STI Dept, Ctr Infect Dis Surveillance & Control, London, England. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA 5E BP S34 EP S35 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500113 ER PT J AU Fine, D Fanfair, RN Salomon, S Nakatsukasa-Ono, W Markowitz, L AF Fine, David Fanfair, Robyn Neblett Salomon, Sarah Nakatsukasa-Ono, Wendy Markowitz, Lauri TI CHLAMYDIA TRACHOMATIS (CT) IN OLDER FEMALE FAMILY PLANNING (FP) CLINIC CLIENTS: ASSESSING EFFECTIVENESS AND EFFICIENCY OF SCREENING ALGORITHMS BASED ON USPHS REGION X INFERTILITY PREVENTION PROJECT (IPP) RECORDS, 2009-2011 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Fine, David; Salomon, Sarah; Nakatsukasa-Ono, Wendy] Cardea Serv, Seattle, WA USA. [Fanfair, Robyn Neblett] CDC, Atlanta, GA 30333 USA. Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. NR 0 TC 1 Z9 1 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA 1B2 BP S7 EP S8 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500024 ER PT J AU Flagg, EW Weinstock, HS AF Flagg, Elaine W. Weinstock, Hillard S. TI USE OF ADMINISTRATIVE HEALTH CARE DATA FOR SEXUALLY TRANSMITTED DISEASE SURVEILLANCE SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Flagg, Elaine W.; Weinstock, Hillard S.] Ctr Dis Control & Prevent, Atlanta, GA USA. EM ewf2@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 109 BP S68 EP S69 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500236 ER PT J AU Fleming, E Hogben, M AF Fleming, Eleanor Hogben, Matthew TI ASSESSING DIFFERENT PARTNER NOTIFICATION METHODS IN ASSURING PARTNER TREATMENT FOR GONORRHEA SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Fleming, Eleanor] CDC, NCHHSTP, Atlanta, GA 30333 USA. [Hogben, Matthew] Ctr Dis Control & Prevent, Atlanta, GA USA. EM efleming@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 113 BP S70 EP S70 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500240 ER PT J AU Flemming, T Hess, P Alfonso, M Lum, G Furness, B AF Flemming, Toni Hess, Paul Alfonso, Maria Lum, Garret Furness, Bruce TI BANG FOR THE BUCK: THE PARTNER SERVICES EXPERIENCE IN WASHINGTON, DC SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Flemming, Toni; Hess, Paul; Furness, Bruce] Ctr Dis Control & Prevent, DSTDP, Washington, DC USA. [Alfonso, Maria; Lum, Garret] DC Dept Hlth, Washington, DC USA. EM toni.flemming@dc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 9 BP S98 EP S98 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500342 ER PT J AU Friedman, A Daniels, B Uhrig, J Gilbert, L Poehlman, J AF Friedman, Allison Daniels, Booker Uhrig, Jennifer Gilbert, Lisa Poehlman, Jon TI UNDERSTANDING AFRICAN AMERICANS' PERCEPTIONS OF SEXUAL HEALTH: FINDINGS FROM AN ONLINE NATIONAL SURVEY AND IMPLICATIONS FOR HEALTH COMMUNICATION INTERVENTIONS SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Friedman, Allison] NCHHSTP, CDC, Atlanta, GA USA. [Daniels, Booker] CDC, Atlanta, GA 30333 USA. [Uhrig, Jennifer; Gilbert, Lisa; Poehlman, Jon] RTI Int, Res Triangle Pk, NC USA. EM alf8@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP198 BP S148 EP S148 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500531 ER PT J AU Friedman, M Hennessy, R Schillinger, J Klingler, E AF Friedman, Mark Hennessy, Robin Schillinger, Julia Klingler, Ellen TI IMPROVEMENTS IN TIMELINESS OF SYPHILIS SURVEILLANCE AND DISEASE INTERVENTION ACTIVITIES FROM A NEWLY IMPLEMENTED SURVEILLANCE/CASE MANAGEMENT SYSTEM SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Friedman, Mark; Klingler, Ellen] NYC Dept Hlth & Mental Hyg, Queens, NY USA. [Hennessy, Robin] New York City Dept Hlth & Mental Hyg, Queens, NY USA. [Schillinger, Julia] Ctr Dis Control & Prevent, Div Sexually Transmitted Dis Prevent, Queens, NY USA. EM mfmefriedman@msn.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 142 BP S77 EP S78 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500269 ER PT J AU Furness, B Shah, Y Kharfen, M Dooley, D AF Furness, Bruce Shah, Yasir Kharfen, Michael Dooley, Danielle TI INCORPORATING HIV TESTING INTO A CITY-WIDE SCHOOL-BASED STD SCREENING PROGRAM SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Furness, Bruce] Ctr Dis Control & Prevent, DSTDP, Washington, DC USA. [Shah, Yasir; Kharfen, Michael] DC Dept Hlth, Washington, DC USA. [Dooley, Danielle] Unity Hlth Care Inc, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 53 BP S110 EP S110 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500386 ER PT J AU Gallo, M Legardy-Williams, J Steiner, M Macaluso, M Hobbs, M Hylton-Kong, T Anderson, C Carter, M Costenbader, E Warner, L AF Gallo, Maria Legardy-Williams, Jennifer Steiner, Markus Macaluso, Maurizio Hobbs, Marcia Hylton-Kong, Tina Anderson, Clive Carter, Marion Costenbader, Elizabeth Warner, Lee TI CONDOM USE SELF-EFFICACY AND EXPOSURE TO SEMEN AMONG FEMALE STI CLINIC PATIENTS IN KINGSTON, JAMAICA SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Gallo, Maria] Ohio State Univ, Columbus, OH 43210 USA. [Legardy-Williams, Jennifer] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA. [Macaluso, Maurizio] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA. [Hobbs, Marcia] Univ N Carolina, Chapel Hill, NC USA. [Anderson, Clive] Univ W Indies, Off Vice Chancellor, Kingston, Jamaica. [Carter, Marion] CDC, Hlth Serv Res & Evaluat Branch, Atlanta, GA 30333 USA. [Warner, Lee] Ctr Dis Control & Prevent, Atlanta, GA USA. EM mgallo@cph.osu.edu RI Macaluso, Maurizio/J-2076-2015 OI Macaluso, Maurizio/0000-0002-2977-9690 NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 163 BP S83 EP S83 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500290 ER PT J AU Gallo, M Margolis, A Malotte, CK Rietmeijer, C Klausner, J O'Donnell, L Warner, L AF Gallo, Maria Margolis, Andrew Malotte, C. Kevin Rietmeijer, Cornelis Klausner, Jeffrey O'Donnell, Lydia Warner, Lee TI SEXUAL ABSTINENCE BY SEXUALLY TRANSMITTED CLINIC PATIENTS IMMEDIATELY FOLLOWING A NEW STI DIAGNOSIS: SAFE IN THE CITY TRIAL SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Gallo, Maria] Ohio State Univ, Columbus, OH 43210 USA. [Margolis, Andrew; Warner, Lee] Ctr Dis Control & Prevent, Atlanta, GA USA. [Malotte, C. Kevin] Calif State Univ Long Beach, Long Beach, CA 90840 USA. [Rietmeijer, Cornelis] Denver Publ Hlth, Denver, CO USA. [Klausner, Jeffrey] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. [Klausner, Jeffrey] Fielding Sch Publ Hlth, Los Angeles, CA USA. [O'Donnell, Lydia] Educ Dev Ctr Inc, Newton, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA 4C2 BP S27 EP S27 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500091 ER PT J AU Garbers, S Friedman, A Martinez, O Scheinmann, R Bermudez, D Chiasson, MA AF Garbers, Samantha Friedman, Allison Martinez, Omar Scheinmann, Roberta Bermudez, Dayana Chiasson, Mary Ann TI USING FORMATIVE RESEARCH TO ADAPT THE GYT CAMPAIGN FOR SEXUAL AND GENDER MINORITY YOUTH OF COLOR IN NEW YORK CITY SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Garbers, Samantha; Scheinmann, Roberta; Bermudez, Dayana; Chiasson, Mary Ann] Publ Hlth Solut, New York, NY USA. [Friedman, Allison] CDC, NCHHSTP, Atlanta, GA 30333 USA. [Martinez, Omar] Columbia Univ, New York, NY USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 45 BP S107 EP S108 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500378 ER PT J AU Garbers, S Friedman, A Scheinmann, R Bermudez, D Chiasson, MA AF Garbers, Samantha Friedman, Allison Scheinmann, Roberta Bermudez, Dayana Chiasson, Mary Ann TI IMPACT OF AN ADAPTED CAMPAIGN TO REACH STREET-ORIENTED SEXUAL & GENDER MINORITY YOUTH IN NEW YORK CITY WITH STI TESTING MESSAGES SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Garbers, Samantha; Scheinmann, Roberta; Bermudez, Dayana; Chiasson, Mary Ann] Publ Hlth Solut, New York, NY USA. [Friedman, Allison] CDC, NCHHSTP, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 44 BP S107 EP S107 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500377 ER PT J AU Garon, J Nelson, R Torrone, E Carey, D AF Garon, Julie Nelson, Robert Torrone, Elizabeth Carey, Delicia TI REVISITING STD DATA RE-RELEASE GUIDELINES SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Garon, Julie; Nelson, Robert; Torrone, Elizabeth; Carey, Delicia] Ctr Dis Control & Prevent, Atlanta, GA USA. EM wvd9@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 114 BP S70 EP S70 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500241 ER PT J AU Gift, T Spence, O AF Gift, Thomas Spence, O'Mareen TI INFERTILITY AND QUALITY OF LIFE: FINDINGS FROM A LITERATURE REVIEW SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Gift, Thomas] Ctr Dis Control & Prevent, Atlanta, GA USA. [Spence, O'Mareen] GDH Consulting, Alabama Medicaid Agcy, Montgomery, AL USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 72 BP S115 EP S115 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500405 ER PT J AU Goodwin, C Hennessy, R Schillinger, J AF Goodwin, Christopher Hennessy, Robin Schillinger, Julia TI TREATMENT VERIFICATION AMONG CASES OF GONORRHEA REPORTED FROM FEDERALLY QUALIFIED HEALTH CENTERS, NEW YORK CITY, 2012 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Goodwin, Christopher] Ctr Dis Control & Prevent, Publ Hlth Associate Program, Queens, NY USA. [Hennessy, Robin] New York City Dept Hlth & Mental Hyg, Queens, NY USA. [Schillinger, Julia] Ctr Dis Control & Prevent, Div Sexually Transmitted Dis Prevent, Queens, NY USA. EM cgoodwin1@health.nyc.gov NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 196 BP S92 EP S92 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500323 ER PT J AU Guarner, J Pillay, A Jost, H Sun, YC Cox, DL Notenboom, R Workowski, K AF Guarner, Jeannette Pillay, Allan Jost, Heather Sun, Yongcheng Cox, David L. Notenboom, Robert Workowski, Kimberly TI EVALUATION OF TREPONEMAL TESTS FOR IMPROVED DIAGNOSIS OF NEUROSYPHILIS SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Guarner, Jeannette; Workowski, Kimberly] Emory Univ, Atlanta, GA 30322 USA. [Pillay, Allan; Jost, Heather; Cox, David L.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Sun, Yongcheng] Syphilis Lab Reference & Res Branch, Atlanta, GA USA. EM jguarne@emory.edu RI Guarner, Jeannette/B-8273-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 149 BP S135 EP S135 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500482 ER PT J AU Gupta, A Rogers, M Abbott, S Gorwitz, R Dunne, E Schillinger, J AF Gupta, Akash Rogers, Meighan Abbott, Sharon Gorwitz, Rachel Dunne, Eileen Schillinger, Julia TI STD DIAGNOSIS AND MANAGEMENT PRACTICES IN FEDERALLY QUALIFIED HEALTH CENTER CLINICS IN NEW YORK CITY, 2012 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Gupta, Akash; Gorwitz, Rachel; Dunne, Eileen] Ctr Dis Control & Prevent, Atlanta, GA USA. [Rogers, Meighan] New York City Dept Hlth & Mental Hyg, New York, NY USA. [Abbott, Sharon] Cicatelli Associates Inc, New York, NY USA. [Schillinger, Julia] Ctr Dis Control & Prevent, Div Sexually Transmitted Dis Prevent, Queens, NY USA. EM xix5@cdc.gov NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 80 BP S61 EP S61 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500207 ER PT J AU Habel, MA Leichliter, J Torrone, E AF Habel, Melissa A. Leichliter, Jami Torrone, Elizabeth TI EXPLORING CHLAMYDIA POSITIVITY AMONG FEMALES ON COLLEGE CAMPUSES, 2008-2010 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Habel, Melissa A.; Leichliter, Jami; Torrone, Elizabeth] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA 3A4 BP S18 EP S19 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500061 ER PT J AU Haderxhanaj, L Chesson, H Aral, S Leichliter, J AF Haderxhanaj, Laura Chesson, Harrell Aral, Sevgi Leichliter, Jami TI THE DISTRIBUTION OF SEX PARTNERS IN THE UNITED STATES BY SEXUAL IDENTITY, 2002 AND 2006-2010 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Haderxhanaj, Laura; Aral, Sevgi; Leichliter, Jami] CDC, Atlanta, GA 30333 USA. [Chesson, Harrell] Ctr Dis Control & Prevent, Atlanta, GA USA. EM vzo6@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 114 BP S126 EP S126 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500447 ER PT J AU Haderxhanaj, L Gift, T Torrone, E Behl, A Romaguera, R Leichliter, J AF Haderxhanaj, Laura Gift, Thomas Torrone, Elizabeth Behl, Ajay Romaguera, Raul Leichliter, Jami TI ESTIMATING THE SIZE AND COST OF SERVICES OF THE SAFETY NET POPULATION FOR STD PREVENTION SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Haderxhanaj, Laura; Leichliter, Jami] CDC, Atlanta, GA 30333 USA. [Gift, Thomas; Torrone, Elizabeth; Romaguera, Raul] Ctr Dis Control & Prevent, Atlanta, GA USA. [Behl, Ajay] Hlth Partners Inst Educ & Res, Pingtung, Taiwan. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA 3C2 BP S20 EP S21 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500069 ER PT J AU Ham, C Fleischauer, A Clymore, J Leone, P AF Ham, Cal Fleischauer, Aaron Clymore, Jacquelyn Leone, Peter TI OPPORTUNITIES FOR EXPANDED HIV AND STD MANAGEMENT IN FEDERALLY QUALIFIED HEALTH CENTERS (FQHCS) - NORTH CAROLINA'S EXPERIENCE SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Ham, Cal] Ctr Dis Control & Prevent, Atlanta, GA USA. [Fleischauer, Aaron] Norht Carolina Div Publ Hlth, Raleigh, NC USA. [Clymore, Jacquelyn] North Carolina Div Publ Hlth, Raleigh, NC USA. [Leone, Peter] Univ N Carolina, Sch Med, Chapel Hill, NC USA. EM cal1477@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 138 BP S132 EP S132 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500471 ER PT J AU Ham, C Guardado, M Nieto, A Northbrook, S Kamb, M AF Ham, Cal Guardado, Maria Nieto, Ana Northbrook, Sanny Kamb, Mary TI FACTORS ASSOCIATED WITH HIV AMONG MEN WHO HAVE SEX WITH MEN IN 2 CITIES IN EL SALVADOR: THE IMPORTANCE OF OTHER STIS SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Ham, Cal; Kamb, Mary] Ctr Dis Control & Prevent, Atlanta, GA USA. [Guardado, Maria] TEPHINET, Guatemala City, Guatemala. [Nieto, Ana] El Salvador Natl AIDS Program, San Salvador, El Salvador. [Northbrook, Sanny] CDC Cent Amer, Guatemala City, Guatemala. EM cal1477@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 161 BP S82 EP S83 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500288 ER PT J AU Hamarman, A Mason, P Kroeger, K Alexander-Pender, C AF Hamarman, Amelia Mason, Patricia Kroeger, Karen Alexander-Pender, Carla TI THE IMPACT OF BUDGET CUTS AMONG LOCAL STD PROGRAMS IN NEW JERSEY: RESULTS OF A RAPID ETHNOGRAPHIC ASSESSMENT SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Hamarman, Amelia; Mason, Patricia] New Jersey Dept Hlth, Trenton, NJ USA. [Kroeger, Karen; Alexander-Pender, Carla] Ctr Dis Control & Prevent, Atlanta, GA USA. EM knk2@cdc.gov NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 198 BP S93 EP S93 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500325 ER PT J AU Henning, T Papp, J McNicholl, J Kersh, E AF Henning, Tara Papp, John McNicholl, Janet Kersh, Ellen TI COINFECTION WITH TRICHOMONAS VAGINALIS AND CHLAMYDIA TRACHOMATIS WIDENS THE SUSCEPTIBILITY WINDOW FOR SIMIAN-HUMAN IMMUNODEFICIENCY VIRUS (SHIV) ACQUISITION IN PIGTAIL MACAQUES SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Henning, Tara; Papp, John; McNicholl, Janet; Kersh, Ellen] Ctr Dis Control & Prevent, Atlanta, GA USA. EM idz4@cdc.gov NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 146 BP S134 EP S135 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500479 ER PT J AU Hogben, M Brookmeyer, K Heyer, K Kachur, R Habel, M Friedman, A McFarlane, M AF Hogben, Matthew Brookmeyer, Kathryn Heyer, Kate Kachur, Rachel Habel, Melissa Friedman, Allison McFarlane, Mary TI YOUTH ATTITUDES TOWARD DIMENSIONS OF SEXUAL HEALTH SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Hogben, Matthew; Brookmeyer, Kathryn; Kachur, Rachel; Habel, Melissa; Friedman, Allison] Ctr Dis Control & Prevent, Atlanta, GA USA. [Heyer, Kate] NACCHO, Washington, DC USA. [Friedman, Allison] CDC, NCHHSTP, Atlanta, GA 30333 USA. [McFarlane, Mary] CDC, Atlanta, GA 30333 USA. EM MHogben@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 45 BP S51 EP S52 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500172 ER PT J AU Hoover, KW Parsell, B Leichliter, J Habel, M Tao, GY Heyer, K Gift, T AF Hoover, Karen W. Parsell, Bradley Leichliter, Jami Habel, Melissa Tao, Guoyu Heyer, Kate Gift, Tom TI STD CLINICS ARE AN IMPORTANT PART OF THE US HEALTHCARE SAFETY NET SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Hoover, Karen W.; Leichliter, Jami; Habel, Melissa; Tao, Guoyu; Gift, Tom] Ctr Dis Control & Prevent, Atlanta, GA USA. [Parsell, Bradley] Univ Chicago, NORC, Chicago, IL 60637 USA. [Heyer, Kate] NACCHO, Washington, DC USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 104 BP S123 EP S123 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500437 ER PT J AU Howard, S Pilgrim, N Jennings, J Sonenstein, F Arrington-Sanders, R Page, K Dittius, P Lousier, P Marcell, A AF Howard, Shalynn Pilgrim, Nanlesta Jennings, Jacky Sonenstein, Freya Arrington-Sanders, Renata Page, Kathleen Dittius, Patricia Loosier, Penny Marcell, Arik TI PROJECT CONNECT BALTIMORE: HIV TESTING AT COMMUNITY-BASED YOUTH-SERVING AGENCIES SERVING YOUNG MINORITY MALES SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Howard, Shalynn; Marcell, Arik] Johns Hopkins Univ, Baltimore, MD USA. [Pilgrim, Nanlesta; Sonenstein, Freya] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Jennings, Jacky; Page, Kathleen] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Arrington-Sanders, Renata] Johns Hopkins Sch Med, Baltimore, MD USA. [Dittius, Patricia] Ctr Dis Control & Prevent, Atlanta, GA USA. [Loosier, Penny] CDC, Div STD Prevent, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 50 BP S109 EP S109 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500383 ER PT J AU Hoyte, T Fisher, H Flores, S Dietz, P Stratford, D AF Hoyte, Tamika Fisher, Holly Flores, Stephen Dietz, Patricia Stratford, Dale TI EVALUATING HIGH IMPACT HIV PREVENTION IN 12 US CITIES: LESSONS FOR THE STD PROGRAM EVALUATOR SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Hoyte, Tamika; Fisher, Holly; Flores, Stephen; Dietz, Patricia; Stratford, Dale] Ctr Dis Control & Prevent, Atlanta, GA USA. EM thoyte@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 123 BP S72 EP S72 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500250 ER PT J AU Johnson, DM Salomon, S Warner, L Carlon, A Fine, D AF Johnson, David M. Salomon, Sarah Warner, Lee Carlon, Alfonso Fine, David TI MALE REPRODUCTIVE HEALTH PROJECT 2009-2013: PROGRAM IMPLEMENTATION, RESEARCH RESULTS AND IMPLICATIONS FOR STD SERVICE DELIVERY SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Johnson, David M.] US DHHS Off Populat Affairs, Off Family Planning, Rockville, MD USA. [Salomon, Sarah; Fine, David] Cardea Serv, Seattle, WA USA. [Warner, Lee] Ctr Dis Control & Prevent, Atlanta, GA USA. [Carlon, Alfonso] Cardea Serv, Austin, TX USA. EM david.johnson@hhs.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA 6C3 BP S38 EP S38 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500124 ER PT J AU Kachur, R AF Kachur, Rachel TI DEVELOPMENT AND EVALUATION OF AN HIV/STD-FOCUSED MOTION COMIC FOR YOUNG PEOPLE AGES 15-24 YEARS IN THE US SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Kachur, Rachel] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 59 BP S111 EP S111 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500392 ER PT J AU Kidd, S Stenger, M Llata, E Weinstock, HS AF Kidd, Sarah Stenger, Mark Llata, Eloisa Weinstock, Hillard S. TI BEYOND THE NATIONAL RATE: REGIONAL VARIATION IN GONORRHEA TRENDS-UNITED STATES, 2009-2012 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Kidd, Sarah; Stenger, Mark; Llata, Eloisa] CDC, Atlanta, GA 30333 USA. [Weinstock, Hillard S.] Ctr Dis Control & Prevent, Atlanta, GA USA. EM hgk9@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 193 BP S91 EP S91 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500320 ER PT J AU King, H Holtzman, D Xing, J AF King, Hope Holtzman, Deborah Xing, Jian TI HEPATITIS B VACCINATION AMONG HIGH-RISK ADULTS: RESULTS FROM THE NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY (NHANES), 2003-2010 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [King, Hope] Ctr Dis Control & Prevent, Atlanta, GA USA. [Holtzman, Deborah; Xing, Jian] Ctr Dis Control & Prevent, Div Vital Hepatitis, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 97 BP S121 EP S122 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500430 ER PT J AU Kirkcaldy, R Papp, J Soge, O Hook, EW del Rio, C Harrington, S Kubin, G Weinstock, HS AF Kirkcaldy, Robert Papp, John Soge, Olusegun Hook, Edward W., III del Rio, Carlos Harrington, Susan Kubin, Grace Weinstock, Hillard S. TI CEPHALOSPORIN ANTIMICROBIAL SUSCEPTIBILITY OF NEISSERIA GONORRHOEAE IN THE UNITED STATES, 2009-2013 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Kirkcaldy, Robert; Papp, John; Weinstock, Hillard S.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Soge, Olusegun] Univ Washington, Seattle, WA 98195 USA. [Hook, Edward W., III] Univ Alabama Birmingham, Birmingham, AL USA. [del Rio, Carlos] Emory Univ, Atlanta, GA 30322 USA. [Harrington, Susan] Cleveland Clin, Cleveland, OH USA. [Kubin, Grace] Texas Dept State Hlth Serv, Austin, TX USA. RI del Rio, Carlos/B-3763-2012 OI del Rio, Carlos/0000-0002-0153-3517 NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA 6A2 BP S35 EP S36 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500115 ER PT J AU Kotzen, M Schillinger, J Greene, S Cutler, B Braunstein, S Pathela, P Hennessy, R Isaac, B Blank, S Weiss, D AF Kotzen, Mollie Schillinger, Julia Greene, Sharon Cutler, Blayne Braunstein, Sarah Pathela, Preeti Hennessy, Robin Isaac, Beth Blank, Susan Weiss, Don TI THE RELATIONSHIP BETWEEN SEXUALLY TRANSMITTED DISEASES AND INVASIVE MENINGOCOCCAL DISEASE (IMD) IN NYC, 2000-2012 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Kotzen, Mollie; Greene, Sharon; Cutler, Blayne; Braunstein, Sarah; Pathela, Preeti; Isaac, Beth; Blank, Susan; Weiss, Don] New York City Dept Hlth & Mental Hyg, Long Isl City, NY USA. [Schillinger, Julia] Ctr Dis Control & Prevent, Div Sexually Transmitted Dis Prevent, Queens, NY USA. [Hennessy, Robin] New York City Dept Hlth & Mental Hyg, Queens, NY USA. EM mkotzen@health.nyc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 126 BP S73 EP S73 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500253 ER PT J AU Kroeger, K Humbert-Rico, T Staatz, C Alexander-Pender, C Hamarman, A Mason, P AF Kroeger, Karen Humbert-Rico, Tiffany Staatz, Colleen Alexander-Pender, Carla Hamarman, Amelia Mason, Patricia TI "TIMES ARE CHANGING:" TRAINING DISEASE INTERVENTION SPECIALISTS (DIS) TO CONDUCT RAPID ETHNOGRAPHIC ASSESSMENT: IMPLEMENTATION AND EVALUATION OF A PILOT PROJECT IN NEW JERSEY SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Kroeger, Karen; Humbert-Rico, Tiffany; Staatz, Colleen; Alexander-Pender, Carla] Ctr Dis Control & Prevent, Atlanta, GA USA. [Hamarman, Amelia; Mason, Patricia] New Jersey Dept Hlth, Trenton, NJ USA. EM knk2@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 197 BP S92 EP S92 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500324 ER PT J AU Lang, SG Lobato, MN Sosa, L AF Lang, Simona G. Lobato, Mark N. Sosa, Lynn TI EVALUATION OF GONORRHEA SURVEILLANCE - CONNECTICUT, 2011-2013 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Lobato, Mark N.] CDC, Atlanta, GA 30333 USA. [Sosa, Lynn] Connecticut Dept Publ Hlth, Hartford, CT USA. EM simona.lang@ct.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 124 BP S72 EP S73 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500251 ER PT J AU Leston, J Tulloch, S Reilley, B AF Leston, Jessica Tulloch, Scott Reilley, Brigg TI QUALITY IMPROVEMENT: A SYSTEMS APPROACH TO REDUCING HEALTH DISPARITIES SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Leston, Jessica] Northwest Portland Area Indian Hlth Board, Portland, ME USA. [Tulloch, Scott] Ctr Dis Control & Prevent, Atlanta, GA USA. [Reilley, Brigg] Indian Hlth Ser, Albuquerque, NM USA. EM jleston@npaihb.org NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 144 BP S134 EP S134 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500477 ER PT J AU Lewis, F Newman, D Anschuerz, G Mettey, A Asbel, L Walker-Baban, C Richardson-Moore, R Salmon, M AF Lewis, Felicia Newman, Daniel Anschuerz, Greta Mettey, Aaron Asbel, Lenore Walker-Baban, Cherie Richardson-Moore, Regina Salmon, Melinda TI ANOTHER REASON TO STAY IN SCHOOL: PARTNER MEETING PLACE IS SIGNIFICANTLY ASSOCIATED WITH CHLAMYDIA AND/OR GONORRHEA (CT/GC) INFECTION IN STUDENTS TESTING IN A LARGE HIGH SCHOOL STD SCREENING PROGRAM-PHILADELPHIA, 2009-2012 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Lewis, Felicia; Newman, Daniel] Ctr Dis Control & Prevent, Philadelphia, PA USA. [Lewis, Felicia; Anschuerz, Greta; Asbel, Lenore; Walker-Baban, Cherie; Richardson-Moore, Regina; Salmon, Melinda] Philadelphia Dept Publ Hlth, Philadelphia, PA USA. [Mettey, Aaron] New York City Dept Hlth & Mental Hyg, Long Isl City, NY USA. EM felicia.lewis@phila.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 43 BP S51 EP S51 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500170 ER PT J AU Lewis, F Eberhart, M Anschuetz, G Salmon, M Terrell, C Brady, K AF Lewis, Felicia Eberhart, Michael Anschuetz, Greta Salmon, Melinda Terrell, Coleman Brady, Kathleen TI HIGH YIELD OF NEW HIV DIAGNOSES AND PATIENTS WITH HIGH VIRAL LOADS FROM HIV PARTNER SERVICES, PHILADELPHIA DEPARTMENT OF PUBLIC HEALTH STD CONTROL PROGRAM (STDCP) AND AIDS ACTIVITIES COORDINATING OFFICE (AACO), 2012 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Lewis, Felicia] Ctr Dis Control & Prevent, Philadelphia, PA USA. [Lewis, Felicia; Eberhart, Michael; Anschuetz, Greta; Salmon, Melinda; Terrell, Coleman; Brady, Kathleen] Philadelphia Dept Publ Hlth, Philadelphia, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA 5C5 BP S34 EP S34 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500111 ER PT J AU Liddon, N Dunville, R Barrios, L AF Liddon, Nicole Dunville, Richard Barrios, Lisa TI INCREASING ADOLESCENT ACCESS TO SEXUAL HEALTH SERVICES VIA SCHOOLS: FINDINGS FROM AN EXPERT PANEL SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Liddon, Nicole; Dunville, Richard; Barrios, Lisa] Ctr Dis Control & Prevent, Atlanta, GA USA. EM ne16@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 49 BP S52 EP S53 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500176 ER PT J AU Lin, C AF Lin, Carol TI A SIMULATION STUDY OF USING COMPOSITE HPV GENOTYPING ASSAY RESULTS TO MONITOR HUMAN PAPILLOMAVIRUS INFECTIONS SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Lin, Carol] CDC, Atlanta, GA 30333 USA. EM clin@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 143 BP S78 EP S78 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500270 ER PT J AU Lin, L Benard, V Greek, A Roland, K Hawkins, N Saraiya, M AF Lin, Lavinia Benard, Vicki Greek, April Roland, Katherine Hawkins, Nikki Saraiya, Mona TI RACIAL/ETHNIC DIFFERENCES IN HPV PREVALENCE, RISK FACTORS, AND KNOWLEDGE AMONG PATIENTS IN FEDERALLY QUALIFIED HEALTH CENTERS (FQHCS) SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Lin, Lavinia; Benard, Vicki; Roland, Katherine; Hawkins, Nikki; Saraiya, Mona] Ctr Dis Control & Prevent, Atlanta, GA USA. [Greek, April] Battelle Mem Inst, Seattle, WA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 86 BP S118 EP S119 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500419 ER PT J AU Liu, G Hariri, S Bradley, H Gottlieb, SL Leichliter, J Markowitz, L AF Liu, Gui Hariri, Susan Bradley, Heather Gottlieb, Sami L. Leichliter, Jami Markowitz, Lauri TI TRENDS AND PATTERNS OF SEXUAL PRACTICES AMONG ADOLESCENTS AND ADULTS AGED 14-59, UNITED STATES SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Liu, Gui; Hariri, Susan; Bradley, Heather] Ctr Dis Control & Prevent, Atlanta, GA USA. [Leichliter, Jami] CDC, Atlanta, GA 30333 USA. [Markowitz, Lauri] Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. EM wrf8@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 123 BP S128 EP S128 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500456 ER PT J AU Llata, E Schwebke, J Schumacher, C Pathela, P Bernstein, K Kerani, R Weinstock, HS AF Llata, Eloisa Schwebke, Jane Schumacher, Christina Pathela, Preeti Bernstein, Kyle Kerani, Roxanne Weinstock, Hillard S. TI PELVIC INFLAMMATORY DISEASE MANAGEMENT AT SELECTED US STD CLINICS: STD SURVEILLANCE NETWORK, 2010-2011 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Llata, Eloisa] CDC, Atlanta, GA 30333 USA. [Schwebke, Jane] Univ Alabama Birmingham, Birmingham, AL USA. [Schumacher, Christina] Johns Hopkins Sch Publ Hlth, Baltimore, MD USA. [Pathela, Preeti] New York City Dept Hlth & Mental Hyg, Long Isl City, NY USA. [Bernstein, Kyle] Johns Hopkins Sch Publ Hlth, San Francisco, CA USA. [Kerani, Roxanne] Publ Hlth Seattle & King Cty, Seattle, WA USA. [Weinstock, Hillard S.] Ctr Dis Control & Prevent, Atlanta, GA USA. EM gge3@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 66 BP S57 EP S57 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500193 ER PT J AU Marfel, M Edilyong, J Yinnifel, C Farshy, C Barrow, R Papp, J AF Marfel, Maria Edilyong, James Yinnifel, Cyril Farshy, Carol Barrow, Roxanne Papp, John TI ENHANCED LABORATORY TESTING REDUCES CHLAMYDIA TRACHOMATIS INFECTIONS IN YAP, FEDERATED STATES OF MICRONESIA SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Marfel, Maria; Yinnifel, Cyril] Yap Minist Hlth, Colonia, Yap, Mexico. Yap State Hlth Serv, Colonia, Yap, Mexico. [Farshy, Carol; Papp, John] Ctr Dis Control & Prevent, Atlanta, GA USA. [Barrow, Roxanne] Ctr Dis Control & Prevent CDC, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA 4C5 BP S28 EP S28 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500094 ER PT J AU McFarlane, M Kachur, R Hogben, M Brookmeyer, K Heyer, K Friedman, A AF McFarlane, Mary Kachur, Rachel Hogben, Matthew Brookmeyer, Kathryn Heyer, Kate Friedman, Allison TI GYT AWARENESS AND STD TESTING BEHAVIORS AMONG YOUTH AND YOUNG ADULTS SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [McFarlane, Mary] CDC, Atlanta, GA 30333 USA. [Kachur, Rachel; Hogben, Matthew; Brookmeyer, Kathryn] Ctr Dis Control & Prevent, Atlanta, GA USA. [Heyer, Kate] NACCHO, Washington, DC USA. [Friedman, Allison] CDC, NCHHSTP, Atlanta, GA 30333 USA. EM xzm3@cdc.gov NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 44 BP S51 EP S51 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500171 ER PT J AU Meites, E Markowitz, L Paz-Bailey, G Oster, A AF Meites, Elissa Markowitz, Lauri Paz-Bailey, Gabriela Oster, Alexandra TI HPV VACCINE COVERAGE AMONG MEN WHO HAVE SEX WITH MEN - UNITED STATES, 2011 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Meites, Elissa; Markowitz, Lauri] Ctr Dis Control & Prevent Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. [Paz-Bailey, Gabriela; Oster, Alexandra] Ctr Dis Control & Prevent, Atlanta, GA USA. EM emeites@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 19 BP S100 EP S101 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500352 ER PT J AU Michaels, M Gilbert, S Ward, A Pryzby, R Loosier, P AF Michaels, Maureen Gilbert, Susan Ward, Alana Pryzby, Rachel Loosier, Penny TI TESTING SEXUAL HEALTH MESSAGES THAT PROMOTE BENEFITS AND ACTION STEPS: RESULTS FROM END-USERS SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Michaels, Maureen] Michaels Opin Res, New York, NY USA. [Gilbert, Susan; Ward, Alana] Partnership Prevent, Washington, DC USA. [Pryzby, Rachel; Loosier, Penny] Ctr Dis Control & Prevent, Atlanta, GA USA. EM plf4@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP195 BP S147 EP S147 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500528 ER PT J AU Nakatsukasa-Ono, W Fanfair, RN Salomon, S Fine, D Markowitz, L AF Nakatsukasa-Ono, Wendy Fanfair, Robyn Neblett Salomon, Sarah Fine, David Markowitz, Lauri TI HORMONAL CONTRACEPTIVE USE AND RISK OF CHLAMYDIA TRACHOMATIS (CT) INFECTION IN USPHS REGION X FAMILY PLANNING (FP) FEMALE CLIENTS SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Nakatsukasa-Ono, Wendy; Salomon, Sarah; Fine, David] Cardea Serv, Seattle, WA USA. [Fanfair, Robyn Neblett] CDC, Atlanta, GA 30333 USA. [Markowitz, Lauri] Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. EM wono@carcleaservices.org NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 63 BP S56 EP S56 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500190 ER PT J AU Nelson, R Torrone, E Dooley-Edwards, S Caron, J Harvey, A Kidd, S Su, JR Carey, D AF Nelson, Robert Torrone, Elizabeth Dooley-Edwards, Sheila Caron, Julie Harvey, Alesia Kidd, Sarah Su, John R. Carey, Delicia TI STD CASE SURVEILLANCE DATA QUALITY UNITED STATES, 2012 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Nelson, Robert; Torrone, Elizabeth; Dooley-Edwards, Sheila; Caron, Julie; Harvey, Alesia; Su, John R.; Carey, Delicia] Ctr Dis Control & Prevent, Atlanta, GA USA. [Kidd, Sarah] CDC, Atlanta, GA 30333 USA. EM rxn1@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 124 BP S128 EP S129 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500457 ER PT J AU Newman, D Peterman, T Shiver, S AF Newman, Daniel Peterman, Thomas Shiver, Stacy TI GONORRHEA REINFECTIONS IN WOMEN FROM FLORIDA 2000-2011 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Newman, Daniel; Peterman, Thomas] Ctr Dis Control & Prevent, Atlanta, GA USA. [Shiver, Stacy] Florida Dept Hlth, Tallahassee, FL USA. EM dcn7@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 68 BP S57 EP S58 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500195 ER PT J AU Owusu-Edusei, K Chesson, H Gift, T Gilbert, M Brttnham, R Bolan, G AF Owusu-Edusei, Kwame, Jr. Chesson, Harrell Gift, Thomas Gilbert, Mark Brttnham, Robert Bolan, Gail TI EXPLORING THE COST-EFFECTIVENESS OF A HYPOTHETICAL CHLAMYDIA VACCINE FOR YOUNG FEMALES SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Owusu-Edusei, Kwame, Jr.] CDC, Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Chesson, Harrell; Gift, Thomas; Bolan, Gail] Ctr Dis Control & Prevent, Atlanta, GA USA. [Gilbert, Mark; Brttnham, Robert] British Columbia Ctr Dis Control, Vancouver, BC, Canada. EM kfo0@cdc.gov NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 116 BP S70 EP S71 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500243 ER PT J AU Papp, J Rowlinson, MC Razeq, J Wholehan, J Glennen, A Walters, C Iwen, P Lee, L Hagan, C AF Papp, John Rowlinson, Marie-Claire Razeq, Jafar Wholehan, Jason Glennen, Anita Walters, Chaney Iwen, Peter Lee, Lillian Hagan, Celia TI INTRA-LABORATORY VARIABILITY IN THE ETEST (R) METHOD FOR DETERMINING ANTIBIOTIC SUSCEPTIBILITY OF NEISSERIA GONORRHOEAE TO CEFIXIME, CEFTRIAXONE AND AZITHROMYCIN SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Papp, John] Ctr Dis Control & Prevent, Atlanta, GA USA. [Rowlinson, Marie-Claire] Bur Publ Hlth Labs, Baltimore, MD USA. [Razeq, Jafar] Maryland Dept Hlth, Baltimore, MD USA. [Wholehan, Jason] Michigan Dept Community Hlth, Lansing, MI USA. [Glennen, Anita] Minnesota Dept Hlth, St Paul, MN USA. [Walters, Chaney] Mississippi Publ Hlth Labs, Jackson, MS USA. [Iwen, Peter] Nebraska Publ Hlth Lab, Omaha, NE USA. [Lee, Lillian] New York City Dept Hlth & Mental Hyg, New York, NY USA. [Hagan, Celia] Assoc Publ Hlth Labs, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA 5B4 BP S32 EP S32 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500105 ER PT J AU Parrish, A Crosby, R Collins, T Gorbach, P Carrasco, S Kerndt, P Gratzer, B Markowitz, L Meites, E AF Parrish, Adam Crosby, Richard Collins, Tom Gorbach, Pamina Carrasco, Steven Kerndt, Peter Gratzer, Beau Markowitz, Lauri Meites, Elissa TI INTERNALIZED HOMONEGATIVITY AND DISCLOSURE OF SAME-SEX SEXUAL BEHAVIOR TO HEALTHCARE PROVIDERS AMONG YOUNG MEN WHO HAVE SEX WITH MEN SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Parrish, Adam; Crosby, Richard; Collins, Tom] Univ Kentucky, Coll Publ Hlth, Lexington, KY 40506 USA. [Gorbach, Pamina; Carrasco, Steven] Univ Calif Los Angeles, Los Angeles, CA USA. [Kerndt, Peter] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Los Angeles, CA USA. [Gratzer, Beau] Howard Brown Hlth Ctr, Chicago, IL USA. [Markowitz, Lauri; Meites, Elissa] Ctr Dis Control & Prevent Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. EM adam.parrish@uky.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 21 BP S101 EP S101 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500354 ER PT J AU Patel, C Tao, GY Gorwitz, R Hoover, K AF Patel, Chirag Tao, Guoyu Gorwitz, Rachel Hoover, Karen TI 1-2 GRAMS OF AZITHROMYCIN AND CARDIOVASCULAR DEATH AMONG COMMERCIALLY INSURED PERSONS AGED 15-44 YEARS SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Patel, Chirag; Hoover, Karen] Ctr Dis Control & Prevent, Atlanta, GA USA. [Tao, Guoyu; Hoover, Karen] CDC, Atlanta, GA 30333 USA. EM wyp3@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 128 BP S130 EP S130 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500461 ER PT J AU Pathela, P Braunstein, S Shepard, C Schillinger, J AF Pathela, Preeti Braunstein, Sarah Shepard, Colin Schillinger, Julia TI INCIDENCE OF SEXUALLY TRANSMITTED DISEASES AMONG TRANSGENDER PERSONS WITH HIV, NEW YORK CITY, 2000-2010 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Pathela, Preeti; Braunstein, Sarah] New York City Dept Hlth & Mental Hyg, Long Isl City, NY USA. [Shepard, Colin] New York City Dept Hlth & Mental Hyg, New York, NY USA. [Schillinger, Julia] Ctr Dis Control & Prevent, Div Sexually Transmitted Dis Prevent, Queens, NY USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 84 BP S118 EP S118 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500417 ER PT J AU Patton, M So, JR Nelson, R Weinstock, H AF Patton, Monica So, John R. Nelson, Robert Weinstock, Hillard TI PRIMARY AND SECONDARY SYPHILIS IN MEN - UNITED STATES, 2005-2012 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Patton, Monica; So, John R.; Nelson, Robert; Weinstock, Hillard] Ctr Dis Control & Prevent, Atlanta, GA USA. EM gnh9@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 26 BP S46 EP S46 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500153 ER PT J AU Perez, F Hoover, K Juarez, S Salamanca, R Ramos, G Karem, K Flores, F Valencia, C AF Perez, Freddy Hoover, Karen Juarez, Sandra Salamanca, Roxana Ramos, Gilvan Karem, Kevin Flores, Freddy Valencia, Carola TI INFORMING POLICY AND PROGRAM DECISIONS FOR SCALING UP SYPHILIS AND HIV TESTING IN BOLIVIA THROUGH A JOINT TECHNICAL MISSION SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Perez, Freddy] Pan Amer Hlth Org, Washington, DC USA. [Hoover, Karen; Karem, Kevin] CDC, Atlanta, GA 30333 USA. [Salamanca, Roxana] PAHO Bolivia, La Paz, Bolivia. [Ramos, Gilvan; Flores, Freddy; Valencia, Carola] Minist Hlth Bolivia, La Paz, Bolivia. EM perezf@paho.org NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 164 BP S139 EP S139 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500497 ER PT J AU Peterman, T Newman, D Torrone, E Shiver, S AF Peterman, Thomas Newman, Daniel Torrone, Elizabeth Shiver, Sracy TI CUMULATIVE RISK OF REPORTED CHLAMYDIAL INFECTION AMONG WOMEN IN FLORIDA, 2000-2011 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Peterman, Thomas; Newman, Daniel; Torrone, Elizabeth] Ctr Dis Control & Prevent, Atlanta, GA USA. [Shiver, Sracy] Florida Dept Hlth, Tallahassee, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 68 BP S114 EP S114 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500401 ER PT J AU Pillay, A Kikkert, S Kamb, ML Broutet, N Karem, K AF Pillay, Allan Kikkert, Susan Kamb, Mary L. Broutet, Nathalie Karem, Kevin TI WHO/PAHO COLLABORATING CENTRE FOR SYPHILIS SEROLOGY PROFICIENCY TESTING PROGRAM AT THE CDC SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Pillay, Allan; Kikkert, Susan; Karem, Kevin] CDC, Atlanta, GA 30333 USA. [Kamb, Mary L.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Broutet, Nathalie] WHO, Geneva, Switzerland. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA 3F5 BP S23 EP S24 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500079 ER PT J AU Prior, M Salmon, M Walker-Baban, C LaPollo, AB Johnson, C AF Prior, Matthew Salmon, Melinda Walker-Baban, Cherie LaPollo, Archana Bodas Johnson, Caroline TI CONDOMS, CONDOMS EVERYWHERE! - EXAMINING THE REACH AND AWARENESS OF TAKE CONTROL PHILLY! AT TWO YEARS SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Prior, Matthew; Walker-Baban, Cherie; Johnson, Caroline] Philadelphia Dept Publ Hlth, Philadelphia, PA USA. [Salmon, Melinda] Ctr Dis Control & Prevent, Atlanta, GA USA. [LaPollo, Archana Bodas] Publ Hlth Management Corp, Philadelphia, PA USA. EM matt.prior@phila.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 200 BP S93 EP S93 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500327 ER PT J AU Pryzby, R AF Pryzby, Rachel TI STD PREVENTION IN THE TWITTERSPHERE: FOUNDATIONAL ELEMENTS AND PRACTICAL APPLICATIONS SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Pryzby, Rachel] Ctr Dis Control & Prevent, Atlanta, GA USA. EM wwb8@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 140 BP S133 EP S133 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500473 ER PT J AU Pryzby, R Kachur, R AF Pryzby, Rachel Kachur, Rachel TI DEVELOPMENT AND EVALUATION OF AN STD TREATMENT MOBILE APPLICATION FOR HEALTH CARE PROVIDERS SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Pryzby, Rachel; Kachur, Rachel] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA 6A4 BP S36 EP S36 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500117 ER PT J AU Raiford, J Herbst, J Carry, M Browne, F Doherty, I Wechsberg, W AF Raiford, Jerris Herbst, Jeffrey Carry, Monique Browne, Felicia Doherty, Irene Wechsberg, Wendee TI LOW PROSPECTS AND HIGH RISK: STRUCTURAL DETERMINANTS OF SEXUAL HEALTH ASSOCIATED WITH SEXUAL RISK AMONG AN ECONOMICALLY DISADVANTAGED COHORT OF YOUNG AFRICAN AMERICAN WOMEN SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Raiford, Jerris; Herbst, Jeffrey; Carry, Monique] Ctr Dis Control & Prevent, Atlanta, GA USA. [Browne, Felicia] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. [Doherty, Irene] Res Triangle Inst Int, Res Triangle Pk, NC USA. [Wechsberg, Wendee] RTI Int, Res Triangle Pk, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA 3A3 BP S18 EP S18 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500060 ER PT J AU Rasberry, C Morris, E Lesesne, C Carver, L Topete, P Kroupa, E Moore, W Xu, Y Stallworth, L Robin, L AF Rasberry, Catherine Morris, Elana Lesesne, Catherine Carver, Lisa Topete, Pablo Kroupa, Elizabeth Moore, William Xu, Ye Stallworth, LaSamuel Robin, Leah TI ACCESS TO AND WILLINGNESS TO USE SCHOOL-BASED HIV AND STD TESTING AND PREVENTION SERVICES AMONG TEEN YOUNG MEN WHO HAVE SEX WITH MEN SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Rasberry, Catherine; Morris, Elana; Robin, Leah] Ctr Dis Control & Prevent, Atlanta, GA USA. [Lesesne, Catherine; Carver, Lisa; Topete, Pablo; Moore, William; Xu, Ye; Stallworth, LaSamuel] ICF Int, Atlanta, GA USA. [Kroupa, Elizabeth] ICF Int, Seattle, WA USA. EM crasberry@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 27 BP S103 EP S103 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500360 ER PT J AU Rorie, M Zhang, H Zhu, J Song, W Cesa, K Essuon, A Mulatu, M Duffy, N AF Rorie, Michele Zhang, Hui Zhu, Julia Song, Wei Cesa, Kristina Essuon, Aba Mulatu, Mesfin Duffy, Nadezhda TI MONITORING AND EVALUATION OF HIV PARTNER SERVICES PROGRAMS IN THE UNITED STATES: APPROACHES, STRUCTURES, AND LESSONS LEARNED SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Rorie, Michele; Zhang, Hui; Zhu, Julia; Cesa, Kristina; Essuon, Aba; Mulatu, Mesfin; Duffy, Nadezhda] Ctr Dis Control & Prevent, Atlanta, GA USA. [Song, Wei] Northrop Grumman, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA 3B5 BP S20 EP S20 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500067 ER PT J AU Ross, C Hoover, K Tao, GY AF Ross, Christine Hoover, Karen Tao, Guoyu TI PRENATAL SCREENING FOR CHLAMYDIA AND GONORRHEA AND THE ASSOCIATION WITH PAPANICOLAOU TESTING AMONG MEDICAID-INSURED WOMEN UNITED STATES, 2009-2010 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Ross, Christine; Hoover, Karen; Tao, Guoyu] CDC, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA 2B1 BP S12 EP S12 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500041 ER PT J AU Schillinger, J Jamison, K Rogers, M AF Schillinger, Julia Jamison, Kelly Rogers, Meighan TI POTENTIAL BIASES WHEN MEASURING REPEAT CHLAMYDIA TRACHOMATIS INFECTION RATES TO ASSESS THE REAL-WORLD EFFECTIVENESS OF EXPEDITED PARTNER THERAPY, NEW YORK CITY, 2011-2013 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Schillinger, Julia] Ctr Dis Control & Prevent, Div Sexually Transmitted Dis Prevent, Queens, NY USA. [Jamison, Kelly; Rogers, Meighan] New York City Dept Hlth & Mental Hyg, New York, NY USA. EM jschilli@health.nyc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 109 BP S125 EP S125 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500442 ER PT J AU Schumacher, C Kebede, S Juberg, A Muvva, RK Nganga-good, C Miazad, R Marsiglia, V Greiner, A Jennings, J AF Schumacher, Christina Kebede, Samuel Juberg, Arielle Muvva, Ravikiran Nganga-good, Carolyn Miazad, Rafiq Marsiglia, Vincent Greiner, Amelia Jennings, Jacky TI CHARACTERISTICS ASSOCIATED WITH RECENT HIGH VIRAL LOAD AMONG HIV-POSITIVE INDIVIDUALS IN BALTIMORE CITY SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Schumacher, Christina; Greiner, Amelia; Jennings, Jacky] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Kebede, Samuel] Johns Hopkins Univ, Baltimore, MD USA. [Juberg, Arielle] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Muvva, Ravikiran] Johns Hopkins Sch Med, Baltimore City Hlth Dept, Baltimore, MD USA. [Nganga-good, Carolyn; Miazad, Rafiq; Marsiglia, Vincent] Baltimore City Dept Hlth, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 55 BP S110 EP S110 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500388 ER PT J AU Seth, P Wang, GS Sizemore, E Walker, T Figueroa, A Taylor, L Hollis, N Belcher, L AF Seth, Puja Wang, Guoshen Sizemore, Erin Walker, Tanja Figueroa, Argelia Taylor, La'Shan Hollis, NaTasha Belcher, Lisa TI HIV SERVICE DELIVERY TO POPULATIONS AT HIGH RISK ATTENDING STD CLINICS, 55 HEALTH DEPARTMENT JURISDICTIONS, 2011 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Seth, Puja; Wang, Guoshen; Sizemore, Erin; Walker, Tanja; Figueroa, Argelia; Taylor, La'Shan; Hollis, NaTasha; Belcher, Lisa] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA 2F1 BP S16 EP S16 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500053 ER PT J AU Snoeyenbos, G Hoover, K Tao, GY Ault, K Workowski, K AF Snoeyenbos, Gretchen Hoover, Karen Tao, Guoyu Ault, Kevin Workowski, Kimberly TI EVALUATION AND MANAGEMENT OF GENITAL ULCER DISEASE: NON-ADHERENCE TO CDC GUIDELINES SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Snoeyenbos, Gretchen] Emory Univ, Atlanta, GA 30322 USA. [Hoover, Karen; Tao, Guoyu] CDC, Atlanta, GA 30333 USA. [Ault, Kevin; Workowski, Kimberly] Emory Univ Sch Med, Atlanta, GA USA. EM gretchen.snoeyenbos@emory.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 110 BP S125 EP S125 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500443 ER PT J AU Spicknall, I Gift, T Manhart, LE Golden, M AF Spicknall, Ian Gift, Thomas Manhart, Lisa E. Golden, Matthew TI COST-EFFECTIVENESS ANALYSIS OF SCREENING FOR CHLAMYDIA, GONORRHEA, AND M. GENITALIUM: MONOVALENT VERSUS MULTIVALENT TESTING SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Spicknall, Ian] CDC, Atlanta, GA 30333 USA. [Gift, Thomas] Ctr Dis Control & Prevent, Atlanta, GA USA. [Manhart, Lisa E.; Golden, Matthew] Univ Washington, Seattle, WA 98195 USA. EM xfu0@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 116 BP S126 EP S127 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500449 ER PT J AU Spicknall, I Kirkcaldy, R Gift, T Chesson, H Owusu-Edusei, K AF Spicknall, Ian Kirkcaldy, Robert Gift, Thomas Chesson, Harrell Owusu-Edusei, Kwame, Jr. TI MODELING THE IMPACT OF CEPHALOSPORIN-RESISTANT NEISSERIA GONORRHOEAE SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Spicknall, Ian] CDC, Atlanta, GA 30333 USA. [Kirkcaldy, Robert; Gift, Thomas; Chesson, Harrell] Ctr Dis Control & Prevent, Atlanta, GA USA. [Owusu-Edusei, Kwame, Jr.] CDC, Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. EM xfu0@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 115 BP S70 EP S70 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500242 ER PT J AU Steiner, R Michael, S Balaji, A Dittos, P Ethier, K Liddon, N Rapposelli, K Romero, L AF Steiner, Riley Michael, Shannon Balaji, Alexandra Dittos, Patricia Ethier, Kathleen Liddon, Nicole Rapposelli, Karina Romero, Lisa TI YOUTH HIV/STD PREVENTION AND SEXUAL HEALTH CONCEPTUAL FRAMEWORK: A GUIDE FOR ASSESSMENT, PLANNING, AND COMMUNICATION SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Steiner, Riley; Michael, Shannon; Balaji, Alexandra; Dittos, Patricia; Ethier, Kathleen; Liddon, Nicole; Rapposelli, Karina; Romero, Lisa] Ctr Dis Control & Prevent, Atlanta, GA USA. EM rsteiner@cdc.gov NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 53 BP S53 EP S54 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500180 ER PT J AU Stenger, M Anschuetz, G Bernstein, KT Eaglin, M Pathela, P Sosa, L Reed, M Samuel, M Schumacher, C Simon, J Stover, J Jespersen, M Llata, E Weinstock, HS AF Stenger, Mark Anschuetz, Greta Bernstein, Kyle T. Eaglin, Margaret Pathela, Preeti Sosa, Lynn Reed, Mary Samuel, Michael Schumacher, Christina Simon, Julie Stover, Jeff Jespersen, Megan Llata, Eloisa Weinstock, Hillard S. TI DOES IT ALWAYS TAKE TWO TO TANGO? SEX PARTNER CHARACTERISTICS AMONG PERSONS WITH GONORRHEA IN THE STD SURVEILLANCE NETWORK (SSUN), 2010-2012 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Stenger, Mark; Llata, Eloisa] CDC, Atlanta, GA 30333 USA. [Anschuetz, Greta] Philadelphia Dept Publ Hlth, Philadelphia, PA USA. [Bernstein, Kyle T.] San Francisco Dept Publ Hlth, San Francisco, CA USA. [Eaglin, Margaret] City Chicago Dept Publ Hlth, Chicago, IL USA. [Pathela, Preeti] New York City Dept Hlth & Mental Hyg, Long Isl City, NY USA. [Sosa, Lynn] Connecticut Dept Publ Hlth, Hartford, CT USA. [Reed, Mary] Colorado Dept Publ Hlth & Environm, Denver, CO USA. [Samuel, Michael] Calif Dept Publ Hlth, Richmond, VA USA. [Schumacher, Christina] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Simon, Julie] Washington State Dept Hlth, Olympia, WA USA. [Stover, Jeff] Virginia Dept Hlth, Richmond, VA USA. [Jespersen, Megan] LA Off Publ Hlth, New Orleans, LA USA. [Weinstock, Hillard S.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA 1A2 BP S6 EP S6 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500019 ER PT J AU Su, JR Weinstock, HS AF Su, John R. Weinstock, Hillard S. TI CO-INFECTION WITH HUMAN IMMUNODEFICIENCY VIRUS (HIV) AMONG INDIVIDUALS WITH EARLY SYPHILIS, BY STAGE OF SYPHILITIC INFECTION, 17 AREAS - US, 2009-2012 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Su, John R.; Weinstock, Hillard S.] Ctr Dis Control & Prevent, Atlanta, GA USA. EM ezu2@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 29 BP S47 EP S47 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500156 ER PT J AU Swartzendruber, A Sales, JM Fasula, AM Brown, JL Gray, SC Rose, ES DiClemente, RJ AF Swartzendruber, Andrea Sales, Jessica M. Fasula, Amy M. Brown, Jennifer L. Gray, Simone C. Rose, Eve S. DiClemente, Ralph J. TI HISTORY OF LIVE BIRTH PREDICTS SEXUALLY TRANSMITTED INFECTION ACQUISITION OVER 6 MONTHS OF FOLLOW-UP AMONG AFRICAN AMERICAN GIRLS RECRUITED FROM JUVENILE DETENTION CENTERS SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Swartzendruber, Andrea; Sales, Jessica M.; Rose, Eve S.; DiClemente, Ralph J.] Emory Univ, Atlanta, GA 30322 USA. [Fasula, Amy M.; Gray, Simone C.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Brown, Jennifer L.] Texas Tech Univ, Lubbock, TX 79409 USA. EM alswart@emory.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 50 BP S53 EP S53 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500177 ER PT J AU Tao, GY Hoover, K AF Tao, Guoyu Hoover, Karen TI PREVALENCE OF CHLAMYDIA TRACHOMATIS GENITAL INFECTIONS AMONG WOMEN SEEKING ELECTIVE ABORTIONS SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Tao, Guoyu; Hoover, Karen] CDC, Atlanta, GA 30333 USA. EM gat3@cde.gov NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 67 BP S57 EP S57 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500194 ER PT J AU Taylor, M Li, W Skinner, J Mickey, T AF Taylor, Melanie Li, Whitney Skinner, Julia Mickey, Tom TI HIV VIRAL LOADS AMONG YOUNG HIV-INFECTED MEN WITH EARLY SYPHILIS SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Taylor, Melanie] Ctr Dis Control, Phoenix, AZ USA. [Li, Whitney] CDC, Los Angeles, CA USA. [Skinner, Julia] Arizona Dept Hlth Serv, Phoenix, AZ 85007 USA. [Mickey, Tom] Maricopa Cty Dept Publ Hlth, Phoenix, AZ USA. EM vqq8@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 20 BP S101 EP S101 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500353 ER PT J AU Taylor, M Newman, D Skinner, J Mickey, T Gonzales, J AF Taylor, Melanie Newman, Daniel Skinner, Julia Mickey, Tom Gonzales, Jonathan TI HIV STATUS AND VIRAL LOADS AMONG MEN TESTING POSITIVE FOR RECTAL GONORRHEA AND CHLAMYDIA, MAR1COPA COUNTY, ARIZONA, 2011-2013 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Taylor, Melanie] Ctr Dis Control & Prevent, Phoenix, AZ USA. [Newman, Daniel] Ctr Dis Control & Prevent, Atlanta, GA USA. [Skinner, Julia] Arizona Dept Hlth Serv, Phoenix, AZ 85007 USA. [Mickey, Tom] Maricopa Cty Dept Publ Hlth, Phoenix, AZ USA. [Gonzales, Jonathan] ADHS, Phoenix, AZ USA. EM MDT7@CDC.GOV NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 1 BP S40 EP S40 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500128 ER PT J AU Teodoro, N Alfonso, M Coursey, J Hess, P Furness, B AF Teodoro, Nicholas Alfonso, Maria Coursey, John Hess, Paul Furness, Bruce TI FROM PROBLEM FOCUSED TO HOLISTIC: MENTAL HEALTH AND SUBSTANCE ABUSE SCREENING AT AN STD CLINIC SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Teodoro, Nicholas; Coursey, John] DC Dept Hlth, Washington, DC USA. [Alfonso, Maria] DC Deparment Hlth, Washington, DC USA. [Hess, Paul; Furness, Bruce] Ctr Dis Control & Prevent, DSTDP, Washington, DC USA. EM nteodoro@gwu.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 88 BP S63 EP S63 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500215 ER PT J AU Thomas, C Khan, A Dunbar, K Frasure-Williams, J AF Thomas, Craig Khan, Awal Dunbar, Kevin Frasure-Williams, Jessica TI PERFORMANCE MEASUREMENT & PROGRAM IMPROVEMENT: WHERE SHOULD STD PROGRAMS BE HEADING? SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Thomas, Craig] Ctr Dis Control & Prevent, OSTLTS, Atlanta, GA USA. [Khan, Awal] Ctr Dis Control & Prevent, DTBE, Atlanta, GA USA. [Dunbar, Kevin] Natl Chlamydia Screening Programme, Publ Hlth England, London, England. [Frasure-Williams, Jessica] Calif Dept Publ Hlth, STD Control Program, Richmond, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA 2E BP S16 EP S16 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500052 ER PT J AU Torrone, E Mayor, K Taylor, M Furness, B Peterman, T AF Torrone, Elizabeth Mayor, Kelly Taylor, Melanie Furness, Bruce Peterman, Thomas TI SHARING HIV AND STD DATA TO INFORM AND TARGET PREVENTION SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Torrone, Elizabeth; Peterman, Thomas] Ctr Dis Control & Prevent, Atlanta, GA USA. [Mayor, Kelly] Natl Coalit STD Directors, Phoenix, AZ USA. [Taylor, Melanie] Ctr Dis Control, Phoenix, AZ USA. [Furness, Bruce] Ctr Dis Control & Prevent, DSTDP, Washington, DC USA. EM ETorrone@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 112 BP S125 EP S126 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500445 ER PT J AU Torrone, E Weinstock, HS AF Torrone, Elizabeth Weinstock, Hillard S. TI PREVALENCE OF CHLAMYDIA TRACHOMATIS - UNITED STATES, 2007-2010 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Torrone, Elizabeth; Weinstock, Hillard S.] Ctr Dis Control & Prevent, Atlanta, GA USA. EM ETorrone@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 4 BP S96 EP S97 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500337 ER PT J AU Townsend, J Saraiya, M Watson, M Roland, K AF Townsend, Julie Saraiya, Mona Watson, Meg Roland, Katherine TI COMPREHENSIVE CANCER CONTROL EFFORTS TO PROMOTE HUMAN PAPILLOMAVIRUS VACCINATION SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Townsend, Julie; Saraiya, Mona; Watson, Meg; Roland, Katherine] Ctr Dis Control & Prevent, Atlanta, GA USA. EM jtownsend@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 3 BP S96 EP S96 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500336 ER PT J AU Vaidya, S Pathela, P Klingler, E Blank, S Schillinger, J AF Vaidya, Sheila Pathela, Preen Klingler, Ellen Blank, Susan Schillinger, Julia TI SURVEY OF HEALTH CARE PROVIDERS SERVING MEN WHO HAVE SEX WITH MEN SUGGESTS SUBOPTIMAL GONORRHEA DIAGNOSIS AND MANAGEMENT PRACTICES, NEW YORK CITY 2012 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Vaidya, Sheila; Pathela, Preen] New York City Dept Hlth & Mental Hyg, Long Isl City, NY USA. [Blank, Susan; Schillinger, Julia] New York City Dept Hlth & Mental Hyg, Queens, NY USA. [Blank, Susan] Ctr Dis Control & Prevent, Queens, NY USA. EM smv2123@columbia.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 33 BP S48 EP S48 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500160 ER PT J AU Walter, E Dolor, R Kemper, A Unger, E Panicker, G Russell, K Markowitz, L Dunne, E AF Walter, Emmanuel Dolor, Rowena Kemper, Alex Unger, Elizabeth Panicker, Gitika Russell, Kate Markowitz, Lauri Dunne, Eileen TI ANTIBODY TITERS FOLLOWING THE HPV4 SERIES ADMINISTERED AT DELAYED DOSING INTERVALS SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Walter, Emmanuel; Dolor, Rowena; Kemper, Alex; Russell, Kate] Duke Univ, Sch Med, Durham, NC 27706 USA. [Unger, Elizabeth; Panicker, Gitika; Dunne, Eileen] Ctr Dis Control & Prevent, Atlanta, GA USA. [Markowitz, Lauri] Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA 4C3 BP S27 EP S27 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500092 ER PT J AU Warner, L Miller, K Gavin, L Macalso, M AF Warner, Lee Miller, Kim Gavin, Lorrie Macalso, Maurizio TI FACTORS SURROUNDING LACK OF CONDOM USE AT FIRST INTERCOURSE AMONG COLLEGE-AGE MEN SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Warner, Lee] Ctr Dis Control & Prevent, Atlanta, GA USA. [Miller, Kim; Gavin, Lorrie] CDC, Atlanta, GA 30333 USA. [Macalso, Maurizio] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 60 BP S112 EP S112 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500393 ER PT J AU Westheimer, E Pathela, P Schillinger, J Limratana, H Blank, S AF Westheimer, Emily Pathela, Preeti Schillinger, Julia Limratana, Hellen Blank, Susan TI HIGH PREVALENCE OF OROPHARYNGEAL NEISSERIA GONORRHEA INFECTIONS DETECTED BY NUCLEIC ACID AMPLIFICATION TESTING AMONG MEN WHO HAVE SEX WITH MEN MENDING NEW YORK CITY SEXUALLY TRANSMITTED DISEASE CLINICS, 2013 SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Westheimer, Emily; Limratana, Hellen] New York City Dept Hlth & Mental Hyg, Queens, NY USA. [Pathela, Preeti; Blank, Susan] New York City Dept Hlth & Mental Hyg, Long Isl City, NY USA. [Schillinger, Julia] Ctr Dis Control & Prevent, Div Sexually Transmitted Dis Plevent, Queens, NY USA. EM ewestheimer@health.nyc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 23 BP S102 EP S102 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500356 ER PT J AU Williams, SP Hogben, M Alexander-Pender, C Simmons, D Kinsey, J Lloyd, PR Mercurio, M AF Williams, Samantha P. Hogben, Matthew Alexander-Pender, Carla Simmons, Dee Kinsey, Jennine Lloyd, Patricia R. Mercurio, Michael CA Charlotte Reg Off Staff TI A PILOT OF SEXUAL HEALTH GAP ANALYSIS TOOL AND METHODS SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Williams, Samantha P.; Hogben, Matthew; Alexander-Pender, Carla; Kinsey, Jennine] Ctr Dis Control & Prevent, Atlanta, GA USA. [Simmons, Dee] Ctr Dis Control & Prevent, Raleigh, NC USA. [Lloyd, Patricia R.; Charlotte Reg Off Staff] North Carolina Dept Hlth & Human Serv, Charlotte, NC USA. [Mercurio, Michael] Ctr Dis Control & Prevent, Charlotte, NC USA. EM stw8@cdc.gov NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 121 BP S128 EP S128 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500454 ER PT J AU Wilmot, D Yee, M Burke, D Garcia, C Gans, A Smith, L Qiao, ML Baldonado, M Pierson, S Champlin, C Jasso, M Bartok, A Opperman, P White, M AF Wilmot, Duane Yee, Margo Burke, Daniel Garcia, Carmelita Gans, Andrew Smith, Lewis Qiao, Mianling Baldonado, Michael Pierson, Savannah Champlin, Cheryl Jasso, Merced Bartok, Agnes Opperman, Paul White, Mary TI VISUAL CASE ANALYSIS: DEVELOPMENT AND IMPLEMENTATION OF A FUNCTIONAL COMPUTER-BASED VISUAL CASE ANALYSIS TOOL SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Wilmot, Duane; Smith, Lewis] Ctr Dis Control, Atlanta, GA 30333 USA. [Yee, Margo; Burke, Daniel; Garcia, Carmelita; Smith, Lewis; Qiao, Mianling; Baldonado, Michael; Pierson, Savannah; Champlin, Cheryl; Jasso, Merced; Bartok, Agnes; Opperman, Paul] NM Dept Hlth, Santa Fe, NM USA. [White, Mary] FL Dept Hlth, Bradenton, FL USA. EM dfw1@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 136 BP S132 EP S132 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500469 ER PT J AU Folster, JP Pecic, G Stroika, S Rickert, R Whichard, JM AF Folster, J. P. Pecic, G. Stroika, S. Rickert, R. Whichard, J. M. TI Changing plasmid types responsible for extended-spectrum cephalosporin resistance in Escherichia coli O157:H7 in the USA, 1996-2009 SO JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE LA English DT Article DE Antimicrobial resistance; Escherichia coli O157:H7; Resistance plasmid; Cephalosporin resistance ID HEMOLYTIC-UREMIC SYNDROME; UNITED-STATES; BETA-LACTAMASES; SALMONELLA; O157-H7; INFECTION; RISK; ANIMALS; HUMANS; STRAIN AB Escherichia coli O157 is a major cause of food-borne illness. Plasmids are genetic elements that mobilise antimicrobial resistance determinants, including bla(CMY) beta-lactamases that confer resistance to extended-spectrum cephalosporins (ESCs). ESCs are important for treating a variety of infections. IncA/C plasmids are found among diverse sources, including cattle, the principal source of E. coli 0157 infections in humans. IncI1 plasmids are common among E. coli and Salmonella from poultry and other avian sources. To broaden our understanding of the reservoirs of bla(CMY), the types of plasmids carrying bla(CMY) among E. coli O157 were determined. From 1996 to 2009, 3742 E. coli O157 isolates were tested. Eleven isolates (0.29%) were ceftriaxone-resistant and had a bla(CMY)-2-containing plasmid. All four isolates submitted before 2001 as well as a single 2001 isolate had bla(CMY) encoded on IncA/C plasmids, whilst all five isolates submitted after 2001 and a single 2001 isolate had bla(CMY) carried on IncI1 plasmids. The IncI1 plasmids were ST2, ST20 and ST23. We conclude that cephalosporin resistance among E. coli O157:H7 is due to plasmid-encoded bla(CMY) genes and that plasmid types appear to have shifted from IncA/C to Inch. This shift suggests either a change in plasmid type among animal reservoirs or that the organism has expanded into avian reservoirs. More analysis of human, retail meat and food animal isolates is necessary to broaden our understanding of the antimicrobial resistance determinants of ESC resistance among E. coli O157. Published by Elsevier Ltd on behalf of International Society for Chemotherapy of Infection and Cancer. C1 [Folster, J. P.; Pecic, G.; Stroika, S.; Rickert, R.; Whichard, J. M.] US Ctr Dis Control & Prevent CDC, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA. [Folster, J. P.; Pecic, G.] IHRC Inc, Atlanta, GA USA. RP Folster, JP (reprint author), US Ctr Dis Control & Prevent CDC, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA. EM gux8@cdc.gov FU CDC; US Food and Drug Administration (FDA) Center for Veterinary Medicine FX This work was partially supported by an interagency agreement between CDC and the US Food and Drug Administration (FDA) Center for Veterinary Medicine. NR 31 TC 2 Z9 2 U1 1 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 2213-7165 J9 J GLOB ANTIMICROB RE JI J. Glob. Antimicrob. Resist. PD JUN PY 2014 VL 2 IS 2 BP 87 EP 91 DI 10.1016/j.jgar.2014.01.004 PG 5 WC Infectious Diseases; Pharmacology & Pharmacy SC Infectious Diseases; Pharmacology & Pharmacy GA CB9CG UT WOS:000349929000005 PM 27873596 ER PT J AU Mullins, MM DeLuca, JB Crepaz, N Lyles, CM AF Mullins, Mary M. DeLuca, Julia B. Crepaz, Nicole Lyles, Cynthia M. TI Reporting quality of search methods in systematic reviews of HIV behavioral interventions (2000-2010): are the searches clearly explained, systematic and reproducible? SO RESEARCH SYNTHESIS METHODS LA English DT Article DE search reporting; reproducibility of results; systematic search; systematic review; literature review; meta-analysis ID SEXUALLY-TRANSMITTED INFECTIONS; RANDOMIZED CONTROLLED-TRIALS; HEALTH TECHNOLOGY-ASSESSMENT; INJECTING DRUG-USERS; SUB-SAHARAN AFRICA; PREVENTION PROGRAMS; PRISMA STATEMENT; RISK BEHAVIORS; SEX WORKERS; REDUCE AB Systematic reviews are an essential tool for researchers, prevention providers and policy makers who want to remain current with the evidence in the field. Systematic review must adhere to strict standards, as the results can provide a more objective appraisal of evidence for making scientific decisions than traditional narrative reviews. An integral component of a systematic review is the development and execution of a comprehensive systematic search to collect available and relevant information. A number of reporting guidelines have been developed to ensure quality publications of systematic reviews. These guidelines provide the essential elements to include in the review process and report in the final publication for complete transparency. We identified the common elements of reporting guidelines and examined the reporting quality of search methods in HIV behavioral intervention literature. Consistent with the findings from previous evaluations of reporting search methods of systematic reviews in other fields, our review shows a lack of full and transparent reporting within systematic reviews even though a plethora of guidelines exist. This review underscores the need for promoting the completeness of and adherence to transparent systematic search reporting within systematic reviews. Published 2013. This article is a U.S. Government work and is in the public domain in the USA. C1 [Mullins, Mary M.; DeLuca, Julia B.; Crepaz, Nicole; Lyles, Cynthia M.] CDC, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. RP Mullins, MM (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Prevent Res Branch, 1600 Clifton Rd,Mailstop E-37, Atlanta, GA 30333 USA. EM mmullins@cdc.gov NR 88 TC 4 Z9 4 U1 2 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1759-2879 EI 1759-2887 J9 RES SYNTH METHODS JI Res. Synth. Methods PD JUN PY 2014 VL 5 IS 2 BP 116 EP 130 DI 10.1002/jrsm.1098 PG 15 WC Mathematical & Computational Biology; Multidisciplinary Sciences SC Mathematical & Computational Biology; Science & Technology - Other Topics GA CA0DK UT WOS:000348585300003 PM 26052651 ER PT J AU Basler, CA Bosch, SA Behravesh, CB AF Basler, Colin A. Bosch, Stacey A. Behravesh, Casey Barton TI Clinical veterinarians can help protect the public's health SO JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION LA English DT Letter C1 [Basler, Colin A.; Bosch, Stacey A.; Behravesh, Casey Barton] CDC, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. RP Basler, CA (reprint author), CDC, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. FU Intramural CDC HHS [CC999999] NR 5 TC 0 Z9 0 U1 0 U2 0 PU AMER VETERINARY MEDICAL ASSOC PI SCHAUMBURG PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA SN 0003-1488 EI 1943-569X J9 JAVMA-J AM VET MED A JI JAVMA-J. Am. Vet. Med. Assoc. PD JUN 1 PY 2014 VL 244 IS 11 BP 1245 EP 1245 PG 1 WC Veterinary Sciences SC Veterinary Sciences GA CA6CI UT WOS:000348995600029 PM 24968461 ER PT J AU Savitt, TL Smith, WR Haywood, C Creary, MS AF Savitt, Todd L. Smith, Wally R. Haywood, Carlton, Jr. Creary, Melissa S. TI Use of the Word "Crisis" in Sickle Cell Disease: The Language of Sickle Cell SO JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION LA English DT Article DE sickle cell disease; crisis; history; pain ID RED-BLOOD-CELLS; ABDOMINAL CRISES; HOME MANAGEMENT; PAINFUL CRISIS; ANEMIA; CHILDREN; ADOLESCENTS; ADULTS; VASOOCCLUSION; SPLENECTOMY AB Language matters. The Wards used to tiama,P,P1 desTIPP, disease phenomena are diefieCtien'af society. The authors the use at the Ward "crisis"i in SCD !-frcirro sociologic0),,,h1kION.01,:tePliPal:PP 1 patient PerSpeCtivei.-itieterrp,erisis7TOeComeosseciatedwithSickle cel disease in thernia,i9Os,'inore "than ii-deddeafterithe first description of the disease had been Cifiblished.TheTerm hod been used tar centuries in conlunction with fever and as a signifier of severe pain in certain diseases during the nineteenth century. The application of Jerre to thtk6w4p,,,,'disease in t`tiel92Cis'reirlted tram 1514,isiCkins; opservations. of their Patients :Lirgentsitt.;aiiens!ThouahcOMMonly used by tiealth'careorbyrdersand patients today "crisis" not be the appropriate term for sickle cell patients suffering se-vere pain. because people endure differinglemounts, of pain beforestating-they,are crisis." The can be undertreatment, of the Pain Or iniitrustjpetween`PhYsiCians and patient's about Use of 'strong (nbrcatiey Pain-relievers:Some patients believe the term is useful in communicating the severity P Of their pain and the urgency of their need - e.se for relief tram it, especially seeking at hospitaremergency, departments. while others believe "crisis" does not accurately'reflect-theii 4 - severity or seriousness of their situation. C1 [Savitt, Todd L.] E Carolina Univ, Brody Sch Med, Dept Bioeth & Interdisciplinary Studies, Greenville, NC 27834 USA. [Smith, Wally R.] Virginia Commonwealth Univ, Dept Med, Richmond, VA 23298 USA. [Haywood, Carlton, Jr.] Johns Hopkins Berman Inst Bioeth, Baltimore, MD USA. [Creary, Melissa S.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Div Blood Disorders, Atlanta, GA USA. RP Savitt, TL (reprint author), E Carolina Univ, Brody Sch Med, Dept Bioeth & Interdisciplinary Studies, 600 Moye Blvd, Greenville, NC 27834 USA. EM savittT@ecu.edu OI Haywood Jr., Carlton/0000-0002-3574-7871 NR 68 TC 0 Z9 0 U1 1 U2 2 PU NATL MED ASSOC PI WASHINGON PA 1012 10TH ST, N W, WASHINGON, DC 20001 USA SN 0027-9684 J9 J NATL MED ASSOC JI J. Natl. Med. Assoc. PD SUM PY 2014 VL 106 IS 1 BP 23 EP 30 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA AY6DL UT WOS:000347657600004 PM 26744112 ER PT J AU Hamilton, JG Edwards, HM Khoury, MJ Taplin, SH AF Hamilton, Jada G. Edwards, Heather M. Khoury, Muin J. Taplin, Stephen H. TI Cancer Screening and Genetics: A Tale of Two Paradigms SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Editorial Material ID SERVICES-TASK-FORCE; BREAST-CANCER; INCIDENTAL FINDINGS; SUSCEPTIBILITY GENE; PERSONAL GENOMICS; OVARIAN-CANCER; PATIENT AUTONOMY; RISK-ASSESSMENT; RECOMMENDATIONS; UPDATE AB The long-standing medical tradition to "first do no harm" is reflected in population-wide evidence-based recommendations for cancer screening tests that focus primarily on reducing morbidity and mortality. The conventional cancer screening process is predicated on finding early-stage disease that can be treated effectively; yet emerging genetic and genomic testing technologies have moved the target earlier in the disease development process to identify a probabilistic predisposition to disease. Genetic risk information can have varying implications for the health and well-being of patients and their relatives, and has raised important questions about the evaluation and value of risk information. This article explores the paradigms that are being applied to the evaluation of conventional cancer screening tests and emerging genetic and genomic tests of cancer susceptibility, and how these perspectives are shifting and evolving in response to advances in our ability to detect cancer risks. We consider several challenges germane to the evaluation of both categories of tests, including defining benefits and harms in terms of personal and clinical utility, addressing healthcare consumers' information preferences, and managing scientific uncertainty. We encourage research and dialogue aimed at developing a better understanding of the value of all risk information, nongenetic and genetic, to people's lives. (C) 2014 AACR. C1 [Hamilton, Jada G.] Mem Sloan Kettering Canc Ctr, Dept Psychiat & Behav Sci, New York, NY 10022 USA. [Edwards, Heather M.] Frederick Natl Lab Canc Res, SAIC Frederick Inc, Clin Res Directorate CMRP, Frederick, MD USA. [Khoury, Muin J.] NCI, Epidemiol & Genom Res Program, Div Canc Control & Populat Sci, NIH, Rockville, MD USA. [Taplin, Stephen H.] NCI, Proc Care Res Branch, Div Canc Control & Populat Sci, NIH, Rockville, MD USA. [Khoury, Muin J.] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA USA. RP Hamilton, JG (reprint author), Mem Sloan Kettering Canc Ctr, 641 Lexington Ave,7th Floor, New York, NY 10022 USA. EM hamiltoj@mskcc.org FU CCR NIH HHS [HHSN261200800001C]; Intramural NIH HHS [Z99 CA999999]; NCI NIH HHS [HHSN261201300091C, HHSN261200800001E] NR 60 TC 3 Z9 3 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1055-9965 EI 1538-7755 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD JUN PY 2014 VL 23 IS 6 BP 909 EP 916 DI 10.1158/1055-9965.EPI-13-1016 PG 8 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA AT9UD UT WOS:000345270800003 PM 24706727 ER PT J AU Stepman, HCM Tiikkainen, U Stockl, D Vesper, HW Edwards, SH Laitinen, H Pelanti, J Thienpont, LM AF Stepman, Hedwig C. M. Tiikkainen, Ulla Stockl, Dietmar Vesper, Hubert W. Edwards, Selvin H. Laitinen, Harri Pelanti, Jonna Thienpont, Linda M. CA Participating Labs TI Measurements for 8 Common Analytes in Native Sera Identify Inadequate Standardization among 6 Routine Laboratory Assays SO CLINICAL CHEMISTRY LA English DT Article ID EXTERNAL QUALITY ASSESSMENT; CANDIDATE REFERENCE METHODS; INTERNAL ACCURACY CONTROL; DETERMINING TARGET VALUES; SINGLE-DONATION SERA; OF-THE-ART; ASSESSMENT SCHEMES; URIC-ACID; CHOLESTEROL; HARMONIZATION AB BACKGROUND: External quality assessment (EQA) with commutable samples is essential for assessing the quality of assays performed by laboratories, particularly when the emphasis is on their standardization status and interchangeability of results. METHODS: We used a panel of 20 fresh-frozen singledonation serum samples to assess assays for the measurement of creatinine, glucose, phosphate, uric acid, total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides. The commercial random access platforms included: Abbott Architect, Beckman Coulter AU, Ortho Vitros, Roche Cobas, Siemens Advia, and Thermo Scientific Konelab. The assessment was done at the peer group level and by comparison against the all-method trimmed mean or reference method values, where available. The considered quality indicators were intraassay imprecision, combined imprecision (including sample-matrix interference), bias, and total error. Fail/pass decisions were based on limits reflecting state-of-the-art performance, but also limits related to biological variation. RESULTS: Most assays showed excellent peer performance attributes, except for HDL- and LDL cholesterol. Cases in which individual assays had biases exceeding the used limits were the Siemens Advia creatinine (-4.2%), Ortho Vitros phosphate (8.9%), Beckman Coulter AU triglycerides (5.4%), and Thermo Scientific Konelab uric acid (6.4%), which lead to considerable interassay discrepancies. Additionally, large laboratory effects were observed that caused interlaboratory differences of >30%. CONCLUSIONS: The design of the EQA study was well suited for monitoring different quality attributes of as-says performed in daily laboratory practice. There is a need for improvement, even for simple clinical chemistry analytes. In particular, the interchangeability of results remains jeopardized both by assay standardization issues and individual laboratory effects. (C) 2014 American Association for Clinical Chemistry. C1 [Stepman, Hedwig C. M.; Thienpont, Linda M.] Univ Ghent, Fac Pharmaceut Sci, Analyt Chem Lab, B-9000 Ghent, Belgium. [Tiikkainen, Ulla; Laitinen, Harri; Pelanti, Jonna] Labquality, Helsinki, Finland. [Stockl, Dietmar] STT Consulting, Horebeke, Belgium. [Vesper, Hubert W.; Edwards, Selvin H.] Ctr Dis Control & Prevent CDC, Div Sci Lab, Atlanta, GA USA. RP Thienpont, LM (reprint author), Univ Ghent, Fac Pharmaceut Sci, Analyt Chem Lab, Harelbekestr 72, B-9000 Ghent, Belgium. EM linda.thienpont@ugent.be NR 34 TC 18 Z9 18 U1 0 U2 8 PU AMER ASSOC CLINICAL CHEMISTRY PI WASHINGTON PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA SN 0009-9147 EI 1530-8561 J9 CLIN CHEM JI Clin. Chem. PD JUN PY 2014 VL 60 IS 6 BP 855 EP 863 DI 10.1373/clinchem.2013.220376 PG 9 WC Medical Laboratory Technology SC Medical Laboratory Technology GA AT2QG UT WOS:000344778600012 PM 24687951 ER PT J AU Keck, JW Miernyk, KM Bulkow, LR Kelly, JJ McMahon, BJ Sacco, F Hennessy, TW Bruce, MG AF Keck, James W. Miernyk, Karen M. Bulkow, Lisa R. Kelly, Janet J. McMahon, Brian J. Sacco, Frank Hennessy, Thomas W. Bruce, Michael G. TI Helicobacter pylori infection and markers of gastric cancer risk in Alaska Native persons: A retrospective case-control study SO CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY LA English DT Article DE Alaska Native; cagA; Gastric cancer; Helicobacter pylori; Pepsinogen I ID SERUM PEPSINOGEN; HIGH-PREVALENCE; CAGA; ANTIBODY; CARCINOGENESIS; ADENOCARCINOMA; ASSOCIATION; RESISTANCE AB BACKGROUND: Alaska Native persons experience gastric cancer incidence and mortality rates that are three to four times higher than in the general United States population. OBJECTIVE: To evaluate pepsinogen I, pepsinogen I/II ratio, anti-Helicobacter pylori and cytotoxin-associated gene A (CagA) antibody levels, and blood group for their associations with gastric cancer development in Alaska Native people. METHODS: The present analysis was a retrospective case-control study that matched gastric cancers reported to the Alaska Native Tumor Registry from 1969 to 2008 to three controls on known demographic risk factors for H pylori infection, using sera from the Alaska Area Specimen Bank. Conditional logistic regression evaluated associations between serum markers and gastric cancer. RESULTS: A total of 122 gastric cancer cases were included, with sera predating cancer diagnosis (mean = 13 years) and 346 matched controls. One hundred twelve cases (91.8%) and 285 controls (82.4%) had evidence of previous or ongoing H pylori infection as measured by anti-H pylori antibody levels. Gastric cancer cases had a 2.63-fold increased odds of having positive anti-H pylori antibodies compared with their matched controls (P=0.01). In a multivariate model, non-cardia gastric cancer (n=94) was associated with anti-H pylori antibodies (adjusted OR 3.92; P=0.004) and low pepsinogen I level (adjusted OR 6.04; P=0.04). No association between gastric cancer and blood group, anti-CagA antibodies or pepsinogen I/II ratio was found. CONCLUSION: Alaska Native people with gastric cancer had increased odds of previous H pylori infection. Low pepsinogen I level may function as a precancer marker for noncardia cancer. C1 [Keck, James W.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Surveillance Epidemiol & Lab Serv, Atlanta, GA USA. [Keck, James W.; Miernyk, Karen M.; Bulkow, Lisa R.; McMahon, Brian J.; Hennessy, Thomas W.; Bruce, Michael G.] Ctr Dis Control & Prevent, Arctic Investigat Program, Anchorage, AK 99508 USA. [Miernyk, Karen M.; Kelly, Janet J.; McMahon, Brian J.] Alaska Native Tribal Hlth Consortium, Anchorage, AK USA. [Sacco, Frank] Alaska Native Med Ctr, Dept Surg, Anchorage, AK USA. RP Keck, JW (reprint author), Ctr Dis Control & Prevent, Arctic Investigat Program, 4055 Tudor Ctr Dr, Anchorage, AK 99508 USA. EM jameswkeck@gmail.com NR 34 TC 3 Z9 4 U1 0 U2 0 PU PULSUS GROUP INC PI OAKVILLE PA 2902 S SHERIDAN WAY, OAKVILLE, ONTARIO L6J 7L6, CANADA SN 0835-7900 J9 CAN J GASTROENTEROL JI Can. J. Gastroenterol. Hepatol. PD JUN PY 2014 VL 28 IS 6 BP 305 EP 310 PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AR9FX UT WOS:000343879300003 PM 24945184 ER PT J AU Curry, DW Perry, HB Tirmizi, SN Goldstein, AL Lynch, MC AF Curry, Dora Ward Perry, Henry B. Tirmizi, Syed N. Goldstein, Allison L. Lynch, Meg C. TI Assessing the Effectiveness of House-to-House Visits on Routine Oral Polio Immunization Completion and Tracking of Defaulters SO JOURNAL OF HEALTH POPULATION AND NUTRITION LA English DT Article DE Community health workers; Defaulter tracking; Home visits; Oral polio immunization; Polio eradication; Routine immunization ID SOCIAL MOBILIZATION; ERADICATION; COMMUNICATION; COUNTRIES; PROGRAMS; LESSONS; INDIA AB Strengthening routine immunization is one of the four prongs of the Global Polio Eradication Initiative. Using data collected through 30-cluster sample household surveys of caretakers of children aged 12-23 months, this paper assessed the effectiveness of house-to-house visits on routine oral polio immunization completion, using simple frequency tables, bivariate and multivariate logistic regression analyses. Logistic regression results demonstrated that children in households where the caregivers reported receiving a household visit by health workers were more likely to be fully immunized for polio through routine immunization than other children, although results were significant only after correcting for confounders. In Ethiopia and India, children of caregivers who remembered a house-to-house visit were significantly and positively associated with routine polio vaccination completion (OR=2.2 and OR=2.2 respectively). In Angola, the association was positive, though not significant (OR=1.3). The evidence suggests that targeting high-risk areas for house-to-house visits played a role in increasing routine polio vaccination. C1 [Curry, Dora Ward; Tirmizi, Syed N.] CARE USA, Atlanta, GA 30303 USA. [Perry, Henry B.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA. [Goldstein, Allison L.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Curry, DW (reprint author), CARE USA, 151 Ellis St NE, Atlanta, GA 30303 USA. EM dcurry@care.org NR 13 TC 1 Z9 1 U1 0 U2 2 PU ICDDR B PI DHAKA PA MOHAKHALI, 1212 DHAKA, BANGLADESH SN 1606-0997 EI 2072-1315 J9 J HEALTH POPUL NUTR JI J. Heatlh Popul. Nutr. PD JUN PY 2014 VL 32 IS 2 BP 356 EP 366 PG 11 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AR7GB UT WOS:000343746400019 PM 25076672 ER PT J AU DeSisto, CL Kim, SY Sharma, AJ AF DeSisto, Carla L. Kim, Shin Y. Sharma, Andrea J. TI Prevalence Estimates of Gestational Diabetes Mellitus in the United States, Pregnancy Risk Assessment Monitoring System (PRAMS), 2007-2010 SO PREVENTING CHRONIC DISEASE LA English DT Article ID INTERNATIONAL ASSOCIATION; GLUCOSE-INTOLERANCE; OBESITY; RECOMMENDATIONS; CLASSIFICATION; METAANALYSIS; DISPARITIES; DIAGNOSIS; DELIVERY; CRITERIA AB Introduction The true prevalence of gestational diabetes mellitus (GDM) is unknown. The objective of this study was 1) to provide the most current GDM prevalence reported on the birth certificate and the Pregnancy Risk Assessment Monitoring System (PRAMS) questionnaire and 2) to compare GDM prevalence from PRAMS across 2007-2008 and 2009-2010. Methods We examined 2010 GDM prevalence reported on birth certificate or PRAMS questionnaire and concordance between the sources. We included 16 states that adopted the 2003 revised birth certificate. We also examined trends from 2007 through 2010 and included 21 states that participated in PRAMS for all 4 years. We combined GDM prevalence across 2-year intervals and conducted t tests to examine differences. Data were weighted to represent all women delivering live births in each state. Results GDM prevalence in 2010 was 4.6% as reported on the birth certificate, 8.7% as reported on the PRAMS questionnaire, and 9.2% as reported on either the birth certificate or questionnaire. The agreement between sources was 94.1% (percent positive agreement = 3.7%, percent negative agreement = 90.4%). There was no significant difference in GDM prevalence between 2007-2008 (8.1%) and 2009-2010 (8.5%, P = .15). Conclusion Our results indicate that GDM prevalence is as high as 9.2% and is more likely to be reported on the PRAMS questionnaire than the birth certificate. We found no statistical difference in GDM prevalence between the 2 phases. Further studies are needed to understand discrepancies in reporting GDM by data source. C1 [DeSisto, Carla L.] Ctr Dis Control & Prevent, El Paso, TX 79912 USA. [Kim, Shin Y.; Sharma, Andrea J.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP DeSisto, CL (reprint author), Ctr Dis Control & Prevent, 601 Sunland Pk Dr,Suite 200, El Paso, TX 79912 USA. EM cdesisto@cdc.gov OI Sharma, Andrea/0000-0003-0385-0011 NR 30 TC 22 Z9 23 U1 1 U2 6 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD JUN PY 2014 VL 11 AR 130415 DI 10.5888/pcd11.130415 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AR3XI UT WOS:000343522100010 ER PT J AU Pearson, WS Goates, SA Harrykissoon, SD Miller, SA AF Pearson, W. S. Goates, S. A. Harrykissoon, S. D. Miller, S. A. TI State-Based Medicaid Costs for Pediatric Asthma Emergency Department Visits SO PREVENTING CHRONIC DISEASE LA English DT Article ID UNITED-STATES; PROGRAM; CARE AB Introduction The prevalence of childhood asthma in the United States increased from 8.7% in 2001 to 9.5% in 2011. This increased prevalence adds to the costs incurred by state Medicaid programs. We provide state-based cost estimates of pediatric asthma emergency department (ED) visits and highlight an opportunity for states to reduce these costs through a recently changed Centers for Medicare and Medicaid Services (CMS) regulation. Methods We used a cross-sectional design across multiple data sets to produce state-based cost estimates for asthma-related ED visits among children younger than 18, where Medicaid/CHIP (Children's Health Insurance Program) was the primary payer. Results There were approximately 629,000 ED visits for pediatric asthma for Medicaid/CHIP enrollees, which cost $272 million in 2010. The average cost per visit was $433. Costs ranged from $282,000 in Alaska to more than $25 million in California. Conclusions Costs to states for pediatric asthma ED visits vary widely. Effective January 1, 2014, the CMS rule expanded which type of providers can be reimbursed for providing preventive services to Medicaid/CHIP beneficiaries. This rule change, in combination with existing flexibility for states to define practice setting, allows state Medicaid programs to reimburse for asthma interventions that use nontraditional providers (such as community health workers or certified asthma educators) in a nonclinical setting, as long as the service was initially recommended by a physician or other licensed practitioner. The rule change may help states reduce Medicaid costs of asthma treatment and the severity of pediatric asthma. C1 [Pearson, W. S.] Ctr Dis Control & Prevent, Off Associate Director Policy, Atlanta, GA 30329 USA. [Goates, S. A.; Harrykissoon, S. D.; Miller, S. A.] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. RP Pearson, WS (reprint author), Ctr Dis Control & Prevent, Off Associate Director Policy, 1600 Clifton Rd NE,Mailstop E-02, Atlanta, GA 30329 USA. EM Wpearson@cdc.gov NR 21 TC 4 Z9 4 U1 0 U2 2 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD JUN PY 2014 VL 11 AR 140139 DI 10.5888/pcd11.140139 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AR3XI UT WOS:000343522100017 ER PT J AU Ruiz, S Brady, TJ Glasgow, RE Birkel, R Spafford, M AF Ruiz, Sarah Brady, Teresa J. Glasgow, Russell E. Birkel, Richard Spafford, Michelle TI Chronic Condition Self-Management Surveillance: What Is and What Should Be Measured? SO PREVENTING CHRONIC DISEASE LA English DT Article ID CARE; FRAMEWORK; DISEASE AB Introduction The rapid growth in chronic disease prevalence, in particular the prevalence of multiple chronic conditions, poses a significant and increasing burden on the health of Americans. Maximizing the use of proven self-management (SM) strategies is a core goal of the US Department of Health and Human Services. Yet, there is no systematic way to assess how much SM or self-management support (SMS) is occurring in the United States. The purpose of this project was to identify appropriate concepts or measures to incorporate into national SM and SMS surveillance. Methods A multistep process was used to identify candidate concepts, assess existing measures, and select high-priority concepts for further development. A stakeholder survey, an environmental scan, subject matter expert feedback, and a stakeholder priority-setting exercise were all used to select the high-priority concepts for development. Results The stakeholder survey gathered feedback on 32 candidate concepts; 9 concepts were endorsed by more than 66% of respondents. The environmental scan indicated few existing measures that adequately reflected the candidate concepts, and those that were identified were generally specific to a defined condition and not gathered on a population basis. On the basis of the priority setting exercises and environmental scan, we selected 1 concept from each of 5 levels of behavioral influence for immediate development as an SM or SMS indicator. Conclusion The absence of any available measures to assess SM or SMS across the population highlights the need to develop chronic condition SM surveillance that uses national surveys and other data sources to measure national progress in SM and SMS. C1 [Ruiz, Sarah; Spafford, Michelle] Univ Chicago, NORC, Bethesda, MD 20814 USA. [Brady, Teresa J.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Glasgow, Russell E.] Univ Colorado, Sch Med, Aurora, CO USA. [Birkel, Richard] Natl Council Aging, Washington, DC USA. RP Ruiz, S (reprint author), Univ Chicago, NORC, 4350 East-West Hwy, Bethesda, MD 20814 USA. EM ruiz-sarah@norc.org RI Ruiz, Sarah/B-3456-2017 OI Ruiz, Sarah/0000-0002-6428-2321 FU Sanofi FX This project was supported by an award from Sanofi to the National Council on Aging. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the National Institutes of Health. NR 28 TC 2 Z9 2 U1 0 U2 2 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD JUN PY 2014 VL 11 AR 130328 DI 10.5888/pcd11.130328 PG 14 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AR3XI UT WOS:000343522100004 PM 24945239 ER PT J AU St Pierre, J Bach, J Duquette, D Oehlke, K Nystrom, R Silvey, K Zlot, A Giles, R Johnson, J Anders, HM Gwinn, M Bowen, S Khoury, MJ AF St Pierre, Jeanette Bach, Janice Duquette, Debra Oehlke, Kristen Nystrom, Robert Silvey, Kerry Zlot, Amy Giles, Rebecca Johnson, Jenny Anders, H. Mack Gwinn, Marta Bowen, Scott Khoury, Muin J. TI Strategies, Actions, and Outcomes of Pilot State Programs in Public Health Genomics, 2003-2008 SO PREVENTING CHRONIC DISEASE LA English DT Article ID CARE PROVIDER PRACTICE; FAMILY-HISTORY; PATIENT BEHAVIOR; OREGONIANS; DISEASE AB State health departments in Michigan, Minnesota, Oregon, and Utah explored the use of genomic information, including family health history, in chronic disease prevention programs. To support these explorations, the Office of Public Health Genomics at the Centers for Disease Control and Prevention provided cooperative agreement funds from 2003 through 2008. The 4 states' chronic disease programs identified advocates, formed partnerships, and assessed public data; they integrated genomics into existing state plans for genetics and chronic disease prevention; they developed projects focused on prevention of asthma, cancer, cardiovascular disease, diabetes, and other chronic conditions; and they created educational curricula and materials for health workers, policymakers, and the public. Each state's program was different because of the need to adapt to existing culture, infrastructure, and resources, yet all were able to enhance their chronic disease prevention programs with the use of family health history, a low-tech "genomic tool." Additional states are drawing on the experience of these 4 states to develop their own approaches. C1 [St Pierre, Jeanette; Bowen, Scott; Khoury, Muin J.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Bach, Janice; Duquette, Debra] Michigan Dept Community Hlth, Lansing, MI USA. [Oehlke, Kristen] Minnesota Dept Hlth, St Paul, MN USA. [Nystrom, Robert; Silvey, Kerry; Zlot, Amy] Oregon Hlth Author, Portland, OR USA. [Giles, Rebecca; Johnson, Jenny] Utah Dept Hlth, Salt Lake City, UT USA. [Anders, H. Mack; Gwinn, Marta] McKing Consulting Corp, Atlanta, GA USA. RP Bowen, S (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM msb4@cdc.gov FU CDC FX Timothy Baker and Jean Chabut convened the 2002 Chronic Disease Directors' Summit, which inspired the work described here. It was supported by a CDC cooperative agreement. NR 39 TC 0 Z9 0 U1 0 U2 4 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD JUN PY 2014 VL 11 AR 130267 DI 10.5888/pcd11.130267 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AR3XI UT WOS:000343522100002 ER PT J AU Stahre, M Roeber, J Kanny, D Brewer, RD Zhang, XY AF Stahre, Mandy Roeber, Jim Kanny, Dafna Brewer, Robert D. Zhang, Xingyou TI Contribution of Excessive Alcohol Consumption to Deaths and Years of Potential Life Lost in the United States SO PREVENTING CHRONIC DISEASE LA English DT Article ID BINGE DRINKING; US; METAANALYSIS; FREQUENCY AB Introduction Excessive alcohol consumption is a leading cause of premature mortality in the United States. The objectives of this study were to update national estimates of alcohol-attributable deaths (AAD) and years of potential life lost (YPLL) in the United States, calculate age-adjusted rates of AAD and YPLL in states, assess the contribution of AAD and YPLL to total deaths and YPLL among working-age adults, and estimate the number of deaths and YPLL among those younger than 21 years. Methods We used the Centers for Disease Control and Prevention's Alcohol-Related Disease Impact application for 2006-2010 to estimate total AAD and YPLL across 54 conditions for the United States, by sex and age. AAD and YPLL rates and the proportion of total deaths that were attributable to excessive alcohol consumption among working-age adults (2064 y) were calculated for the United States and for individual states. Results From 2006 through 2010, an annual average of 87,798 (27.9/100,000 population) AAD and 2 5 million (831.6/100,000) YPLL occurred in the United States. Age-adjusted state AAD rates ranged from 51.2/100,000 in New Mexico to 19.1/100,000 in New Jersey. Among working-age adults, 9.8% of all deaths in the United States during this period were attributable to excessive drinking, and 69% of all AAD involved working-age adults. Conclusions Excessive drinking accounted for 1 in 10 deaths among working-age adults in the United States. AAD rates vary across states, but excessive drinking remains a leading cause of premature mortality nationwide. Strategies recommended by the Community Preventive Services Task Force can help reduce excessive drinking and harms related to it. C1 [Stahre, Mandy] Washington State Dept Hlth, Olympia, WA 98504 USA. [Roeber, Jim] New Mexico Dept Hlth, Santa Fe, NM USA. [Kanny, Dafna; Brewer, Robert D.; Zhang, Xingyou] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Stahre, M (reprint author), Washington State Dept Hlth, Olympia, WA 98504 USA. EM mandy.stahre@doh.wa.gov FU Robert Wood Johnson Foundation [044149, 059738] FX This article is dedicated to Ron Davis, MD, MA, for his visionary leadership and commitment to the prevention of excessive alcohol use. We thank Henry Wechsler, PhD, retired, Harvard School of Public Health, Harvard University. The development of the ARDI application was supported by generous grants (nos. 044149 and 059738) from the Robert Wood Johnson Foundation to the CDC Foundation. NR 21 TC 43 Z9 44 U1 2 U2 18 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD JUN PY 2014 VL 11 AR 130293 DI 10.5888/pcd11.130293 PG 12 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AR3XI UT WOS:000343522100003 ER PT J AU Cope, JR Frost, M Li, RC Xie, RQ AF Cope, James R. Frost, Melinda Li Richun Xie, Ruiqian TI Assessing Knowledge and Application of Emergency Risk Communication Principles Among Public Health Workers in China SO DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS LA English DT Article DE risk communication; China; policy making; public health practice; emergency response AB Objective: Since 2003, the Chinese National Health and Family Planning Commission (formerly the Ministry of Health) has implemented changes to more effectively communicate risk during public health emergencies. In spite of ongoing improvements, provincial and sub-provincial leaders face barriers, such as established modes of operation, lack of training, shortage of trained risk communicators, and limited understanding and willingness of recipients to mitigate risks. Methods: We assessed the current status of and barriers to risk communication knowledge and practice among public health practitioners in China. We designed the survey questionnaire to capture information related to the risk communication core capacities required by international health regulations and common risk communication principles. Results: Our findings showed that risk communication training has successfully developed an awareness of risk communication principles and the ability to implement those principles in practice in China. Conclusions: Future efforts should focus on areas such as a dedicated risk communication workforce, requirements that public health agencies develop a risk communication plan, and additional training for public health practitioners and their partners. It is critical that the infectious diseases prevention and control law be amended to grant provincial and local public health agencies more autonomy to release information. C1 [Cope, James R.; Frost, Melinda] US Ctr Dis Control & Prevent, Ctr Global Hlth, Global Dis Detect Branch, Atlanta, GA 30333 USA. [Li Richun] China Emerging Infect Dis Program, Beijing, Peoples R China. [Xie, Ruiqian] Chinese Ctr Hlth Educ, Beijing, Peoples R China. RP Cope, JR (reprint author), US Ctr Dis Control & Prevent, Ctr Global Hlth, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM voz4@cdc.gov FU Intramural CDC HHS [CC999999] NR 16 TC 1 Z9 3 U1 0 U2 8 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1935-7893 EI 1938-744X J9 DISASTER MED PUBLIC JI Dis. Med. Public Health Prep. PD JUN PY 2014 VL 8 IS 3 BP 199 EP 205 DI 10.1017/dmp.2014.29 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AQ9NO UT WOS:000343182500005 PM 24785302 ER PT J AU Leary, AD Schwartz, MD Kirk, MA Ignacio, JS Wencil, EB Cibulsky, SM AF Leary, Adam D. Schwartz, Michael D. Kirk, Mark A. Ignacio, Joselito S. Wencil, Elaine B. Cibulsky, Susan M. TI Evidence-Based Patient Decontamination: An Integral Component of Mass Exposure Chemical Incident Planning and Response SO DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS LA English DT Article DE decontamination; chemical hazard release; chemical warfare; emergency preparedness; hazardous substances ID 1-PERCENT SOAPY WATER; SKIN DECONTAMINATION; 0.5-PERCENT BLEACH; REDUCTION PASTE; WARFARE AGENTS; DOMESTIC SWINE; EFFICACY; BURNS; VX; STRATEGIES AB Decontaminating patients who have been exposed to hazardous chemicals can directly benefit the patients' health by saving lives and reducing the severity of toxicity. While the importance of decontaminating patients to prevent the spread of contamination has long been recognized, its role in improving patient health outcomes has not been as widely appreciated. Acute chemical toxicity may manifest rapidly-often minutes to hours after exposure. Patient decontamination and emergency medical treatment must be initiated as early as possible to terminate further exposure and treat the effects of the dose already absorbed. In a mass exposure chemical incident, responders and receivers are faced with the challenges of determining the type of care that each patient needs (including medical treatment, decontamination, and behavioral health support), providing that care within the effective window of time, and protecting themselves from harm. The US Department of Health and Human Services and Department of Homeland Security have led the development of national planning guidance for mass patient decontamination in a chemical incident to help local communities meet these multiple, time-sensitive health demands. This report summarizes the science on which the guidance is based and the principles that form the core of the updated approach. C1 [Leary, Adam D.; Wencil, Elaine B.; Cibulsky, Susan M.] US Dept HHS, Med Countermeasure Strategy & Requirements Div, Off Policy & Planning, Off Assistant Secretary Preparedness & Response, Washington, DC 20201 USA. [Schwartz, Michael D.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, US Dept HHS, Washington, DC USA. [Kirk, Mark A.; Ignacio, Joselito S.] US Dept Homeland Secur, Chem Def Program, Off Hlth Affairs, Washington, DC USA. RP Cibulsky, SM (reprint author), JFK Fed Bldg,15 New Sudbury St,Ste 2126, Boston, MA 02203 USA. EM susan.cibulsky@hhs.gov NR 35 TC 2 Z9 3 U1 0 U2 8 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1935-7893 EI 1938-744X J9 DISASTER MED PUBLIC JI Dis. Med. Public Health Prep. PD JUN PY 2014 VL 8 IS 3 BP 260 EP 266 DI 10.1017/dmp.2014.41 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AQ9NO UT WOS:000343182500014 PM 24867089 ER PT J AU Yen, C Tate, JE Hyde, TB Cortese, MM Lopman, BA Jiang, BM Glass, RI Parashar, UD AF Yen, Catherine Tate, Jacqueline E. Hyde, Terri B. Cortese, Margaret M. Lopman, Benjamin A. Jiang, Baoming Glass, Roger I. Parashar, Umesh D. TI Rotavirus vaccines Current status and future considerations SO HUMAN VACCINES & IMMUNOTHERAPEUTICS LA English DT Review DE rotavirus; diarrhea; gastroenteritis; rotavirus vaccines; vaccine impact ID 1ST 2 YEARS; DIARRHEA-ASSOCIATED HOSPITALIZATIONS; CHILDREN LESS-THAN-5 YEARS; ALL-CAUSE GASTROENTERITIS; UNITED-STATES; US CHILDREN; INTUSSUSCEPTION RISK; IMMUNIZATION PROGRAM; INDIRECT PROTECTION; HEALTH-BENEFITS AB Rotavirus is the leading cause of severe diarrhea among children <5 years worldwide. Currently licensed rotavirus vaccines have been efficacious and effective, with many countries reporting substantial declines in diarrheal and rotavirus-specific morbidity and mortality. However, the full public health impact of these vaccines has not been realized. Most countries, including those with the highest disease burden, have not yet introduced rotavirus vaccines into their national immunization programs. Research activities that may help inform vaccine introduction decisions include (1) establishing effectiveness, impact, and safety for rotavirus vaccines in low-income settings; (2) identifying potential strategies to improve performance of oral rotavirus vaccines in developing countries, such as zinc supplementation; and (3) pursuing alternate approaches to oral vaccines, such as parenteral immunization. Policy-and program-level barriers, such as financial implications of new vaccine introductions, should be addressed to ensure that countries are able to make informed decisions regarding rotavirus vaccine introduction. C1 [Yen, Catherine; Tate, Jacqueline E.; Cortese, Margaret M.; Lopman, Benjamin A.; Jiang, Baoming; Parashar, Umesh D.] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA. [Yen, Catherine; Hyde, Terri B.] Ctr Dis Control & Prevent, Global Immunizat Div, Atlanta, GA USA. [Glass, Roger I.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. RP Yen, C (reprint author), Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA. EM cyen@cdc.gov FU Intramural CDC HHS [CC999999] NR 101 TC 13 Z9 13 U1 1 U2 4 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 2164-5515 EI 2164-554X J9 HUM VACC IMMUNOTHER JI Human Vaccines Immunother. PD JUN PY 2014 VL 10 IS 6 BP 1436 EP 1448 DI 10.4161/hv.28857 PG 13 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA AQ4JV UT WOS:000342763200011 PM 24755452 ER PT J AU Callahan, T AF Callahan, Tegan TI APPLIED PUBLIC HEALTH TRAINING: A GRADUATE'S PERSPECTIVE SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Letter ID MPH EDUCATION; CURRICULUM C1 [Callahan, Tegan] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Callahan, T (reprint author), 159 Murray Hill Ave NE, Atlanta, GA 30317 USA. EM tegan.callahan@gmail.com NR 2 TC 0 Z9 0 U1 0 U2 0 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 IS 6 BP E1 EP E1 DI 10.2105/AJPH.2014.301913 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AP0YC UT WOS:000341791500001 PM 24825221 ER PT J AU Griffin, SO Jones, K Crespin, M AF Griffin, Susan O. Jones, Kari Crespin, Matthew TI Calculating averted caries attributable to school-based sealant programs with a minimal data set SO JOURNAL OF PUBLIC HEALTH DENTISTRY LA English DT Article DE pit and fissure sealants; Markov chains; program evaluation ID COST-EFFECTIVENESS; TEETH AB ObjectivesWe describe a methodology for school-based sealant programs (SBSP) to estimate averted cavities, (i.e., difference in cavities without and with SBSP) over 9 years using a minimal data set. MethodsA Markov model was used to estimate averted cavities. SBSP would input estimates of their annual attack rate (AR) and 1-year retention rate. The model estimated retention 2+ years after placement with a functional form obtained from the literature. Assuming a constant AR, SBSP can estimate their AR with child-level data collected prior to sealant placement on sealant presence, number of decayed/filled first molars, and age. We demonstrate the methodology with data from the Wisconsin SBSP. Finally, we examine how sensitive averted cavities obtained with this methodology is if an SBSP were to over or underestimate their AR or 1-year retention. ResultsDemonstrating the methodology with estimated AR (=7 percent) and 1-year retention (=92 percent) from the Wisconsin SBSP data, we found that placing 31,324 sealants averted 10,718 cavities. Sensitivity analysis indicated that for any AR, the magnitude of the error (percent) in estimating averted cavities was always less than the magnitude of the error in specifying the AR and equal to the error in specifying the 1-year retention rate. We also found that estimates of averted cavities were more robust to misspecifications of AR for higher- versus lower-risk children. ConclusionsWith Excel (Microsoft Corporation, Redmond, WA, USA) spreadsheets available upon request, SBSP can use this methodology to generate reasonable estimates of their impact with a minimal data set. C1 [Griffin, Susan O.] Ctr Dis Control, Div Oral Hlth, Atlanta, GA 30341 USA. [Jones, Kari] Quantitat Hlth Res Inc, Tampa, FL USA. [Crespin, Matthew] Childrens Hlth Alliance Wisconsin, Milwaukee, WI USA. RP Griffin, SO (reprint author), Ctr Dis Control, Div Oral Hlth, 3005 Chamblee Tucker Rd,MSF10, Atlanta, GA 30341 USA. EM sig1@cdc.gov FU Intramural CDC HHS [CC999999] NR 14 TC 2 Z9 2 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-4006 EI 1752-7325 J9 J PUBLIC HEALTH DENT JI J. Public Health Dent. PD SUM PY 2014 VL 74 IS 3 BP 202 EP 209 DI 10.1111/jphd.12047 PG 8 WC Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational Health SC Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational Health GA AP5TG UT WOS:000342141000005 PM 24423023 ER PT J AU Dye, BA Li, XF Lewis, BG Iafolla, T Beltran-Aguilar, ED Eke, PI AF Dye, Bruce A. Li, Xianfen Lewis, Brenda G. Iafolla, Tim Beltran-Aguilar, Eugenio D. Eke, Paul I. TI Overview and quality assurance for the oral health component of the National Health and Nutrition Examination Survey (NHANES), 2009-2010 SO JOURNAL OF PUBLIC HEALTH DENTISTRY LA English DT Article DE NHANES; oral health; data reliability; epidemiology; surveillance; periodontal disease; quality assurance; dental public health ID CASE DEFINITIONS; SURVEILLANCE; PERIODONTITIS; POPULATION AB ObjectiveIn 2009-2010, the oral health component for the National Health and Nutrition Examination Survey (NHANES) focused on adult periodontal health and included a full mouth periodontal examination as well as a series of questions adminis during the home interview. During this period, intraoral assessments were conducted by dental hygienists. MethodsThis report provides oral health content information and results of dental examiner reliability for data collected during NHANES 2009-2010 on 7,189 persons aged 3-19 years and 30 years and older representing the US civilian, noninstitutionalized population in these age groups. ResultsFor caries and dental sealant assessments, Kappa statistics ranged from 0.71 to 1.00. Kappa scores for moderate and severe periodontitis using the Centers for Disease Control and Prevention/American Academy of Periodontology case definition guidelines was 0.70, but were lower for other periodontal status definitions. When defining moderate or severe periodontitis based on the NHANES 2003-2004 study, protocols using data from only three facial periodontal sites, the Kappa scores were 0.64 and 0.55. Interclass correlation coefficients (ICCs) for mean attachment loss were 0.80 or higher for both examiners. Site-specific mean attachment loss ICCs were generally higher for interproximal measurements compared with mid-facial and mid-lingual measurements. ConclusionOverall, the data reliability analyses conducted for 2009-2010 indicate an acceptable level of data quality and that examiner (dental hygienist) performance in this data collection cycle is similar to prior survey periods since the NHANES continuous survey began in 1999. C1 [Dye, Bruce A.; Lewis, Brenda G.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Li, Xianfen] Harris Corp, Fairfax, VA USA. [Iafolla, Tim] Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD USA. [Beltran-Aguilar, Eugenio D.; Eke, Paul I.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Oral Hlth, Atlanta, GA USA. RP Dye, BA (reprint author), CDC NCHS NHANES Program, 3311 Toledo Rd,RM 4416, Hyattsville, MD 20782 USA. EM bfd1@cdc.gov FU NHANES FX The 2009-2010 NHANES oral health component was a funding and content collaborative effort between the NIH / National Institute of Dental and Craniofacial Research, the CDC / National Center for Health Promotion and Disease Prevention Division of Oral Health, and the CDC / National Center for Health Statistics. NR 16 TC 9 Z9 9 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-4006 EI 1752-7325 J9 J PUBLIC HEALTH DENT JI J. Public Health Dent. PD SUM PY 2014 VL 74 IS 3 BP 248 EP 256 DI 10.1111/jphd.12056 PG 9 WC Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational Health SC Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational Health GA AP5TG UT WOS:000342141000011 PM 24849242 ER PT J AU Anderson, RN Copeland, G Hayes, JM AF Anderson, Robert N. Copeland, Glenn Hayes, John Mosely TI Linkages to Improve Mortality Data for American Indians and Alaska Natives: A New Model for Death Reporting? SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID NATIONAL LONGITUDINAL MORTALITY; RACE; IDENTIFICATION; CERTIFICATE; ETHNICITY; PATTERNS; QUALITY; HEALTH AB Racial misclassification is a well-documented weakness of mortality data taken from death certificates. As a result, mortality statistics for American Indians and Alaska Natives (AI/ANs) present, at best, an inaccurate and misleading assessment of mortality in this population. Studies evaluating the quality of race/ethnicity reporting on death certificates have linked data from death certificates to other data sources collected when the decedent was still alive (e. g., Census, Current Population Survey). Such studies have shown substantial misclassification of AI/AN decedents. Despite limitations, linking mortality data from death certificates with data from other sources collected when decedents were living provides opportunities to evaluate and correct misclassification of populations such as AI/AN persons and facilitates the calculation and presentation of more accurate mortality statistics. C1 [Anderson, Robert N.] Ctr Dis Control & Prevent, Div Vital Stat, Natl Ctr Hlth Stat, Hyattsville, MD USA. [Copeland, Glenn] Michigan Dept Community Hlth, Div Vital Records & Hlth Stat, Lansing, MI USA. [Hayes, John Mosely] United South & Eastern Tribes, Tribal Epidemiol Ctr, Nashville, TN USA. RP Anderson, RN (reprint author), Div Vital Stat, 3311 Toledo Rd,Room 7318, Hyattsville, MD 20782 USA. EM RNAnderson@cdc.gov NR 37 TC 1 Z9 1 U1 1 U2 1 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 SU 3 BP S258 EP S262 DI 10.2105/AJPH.2013.301647 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO5DL UT WOS:000341362300006 PM 24754614 ER PT J AU Arias, E Xu, JQ Jim, MA AF Arias, Elizabeth Xu, Jiaquan Jim, Melissa A. TI Period Life Tables for the Non-Hispanic American Indian and Alaska Native Population, 2007-2009 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID OLDER AGES; MORTALITY AB Objectives. We estimated complete period life tables for the non-Hispanic American Indian and Alaska Native (AI/AN) population residing in Contract Health Service Delivery Area (CHSDA) counties for the period 2007-2009. Methods. We used National Vital Statistics System mortality data files for years 2007-2009 corrected for AI/AN misclassification on death certificates, midyear 2008 revised census bridged race intercensal population estimates, and National Vital Statistics System birth data for years 2006-2009. We used the same methodology as that used to estimate official US annual life tables, with some minor modifications. Results. For the period 2007-2009, the non-Hispanic AI/AN population in CHSDA counties had the lowest life expectancy at birth (71.1 years) of any racial/ethnic group for which official US life tables are estimated. By comparison, in 2008, life expectancy at birth was 73.9 years for the non-Hispanic Black population, 78.4 years for the non-Hispanic White population, and 80.8 years for the Hispanic population. Conclusions. The life tables showed a clear mortality disadvantage for the non-Hispanic AI/AN population in CHSDA counties relative to other national populations. The findings suggested that further research is necessary to explore the causes behind these disadvantages. C1 [Arias, Elizabeth; Xu, Jiaquan] Ctr Dis Control & Prevent, Mortal Stat Branch, Div Vital Stat, Natl Ctr Hlth Stat, Hyattsville, MD USA. [Jim, Melissa A.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Arias, E (reprint author), Natl Ctr Hlth Stat, 3311 Toledo Rd,Room 7330, Hyattsville, MD 20782 USA. EM EArias@cdc.gov NR 19 TC 4 Z9 5 U1 0 U2 3 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 SU 3 BP S312 EP S319 DI 10.2105/AJPH.2013.301635 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO5DL UT WOS:000341362300013 PM 24754553 ER PT J AU Bauer, UE Plescia, M AF Bauer, Ursula E. Plescia, Marcus TI Addressing Disparities in the Health of American Indian and Alaska Native People: The Importance of Improved Public Health Data SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material C1 [Bauer, Ursula E.] US Ctr Dis Control & Prevent CDC, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Bauer, UE (reprint author), 4770 Buford Hwy NE MS F-80, Atlanta, GA 30341 USA. EM ubauer@cdc.gov NR 11 TC 2 Z9 2 U1 0 U2 2 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 SU 3 BP S255 EP S257 DI 10.2105/AJPH.2013.301602 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO5DL UT WOS:000341362300005 PM 24754654 ER PT J AU Burrows, NR Cho, P Bullard, KM Narva, AS Eggers, PW AF Burrows, Nilka Rios Cho, Pyone Bullard, Kai McKeever Narva, Andrew S. Eggers, Paul W. TI Survival on Dialysis Among American Indians and Alaska Natives With Diabetes in the United States, 1995-2010 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID STAGE RENAL-DISEASE; CHRONIC KIDNEY-DISEASE; HEMODIALYSIS-PATIENTS; CARDIOVASCULAR-DISEASE; ETHNIC-DIFFERENCES; NUTRITIONAL-STATUS; RISK-FACTOR; RACE; MORTALITY; POPULATION AB Objectives. We assessed survival in American Indians and Alaska Natives (AI/ANs) with end-stage renal disease attributed to diabetes who initiated hemodialysis between 1995 and 2009. Methods. Follow-up extended from the first date of dialysis in the United States Renal Data System until December 31, 2010, kidney transplantation, or death. We used the Kaplan-Meier method to compute survival on dialysis by age and race/ethnicity and Cox regression analysis to compute adjusted hazard ratios (HRs). Results. Our study included 510 666 persons-48% Whites, 2% AI/AN persons, and 50% others. Median follow-up was 2.2 years (interquartile range = 1.1-4.1 years). At any age, AI/AN persons survived longer on hemodialysis than Whites; this finding persisted after adjusting for baseline differences. Among AI/AN individuals, those with full Indian blood ancestry had the lowest adjusted risk of death compared with Whites (HR = 0.58; 95% confidence interval = 0.55, 0.61). The risk increased with declining proportion of AI/AN ancestry. Conclusions. Survival on dialysis was better among AI/AN than White persons with diabetes. Among AI/AN persons, the inverse relationship between risk of death and level of AI/AN ancestry suggested that cultural or hereditary factors played a role in survival. C1 [Burrows, Nilka Rios; Cho, Pyone; Bullard, Kai McKeever] Ctr Dis Control & Prevent, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Narva, Andrew S.; Eggers, Paul W.] NIDDK, NIH, Bethesda, MD 20892 USA. RP Burrows, NR (reprint author), 4770 Buford Highway NE,Mailstop F73, Atlanta, GA 30341 USA. EM nrios@cdc.gov NR 31 TC 1 Z9 1 U1 1 U2 4 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 SU 3 BP S490 EP S495 DI 10.2105/AJPH.2014.301942 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO5DL UT WOS:000341362300034 PM 24754656 ER PT J AU Cheek, JE Holman, RC Redd, JT Haberling, D Hennessy, TW AF Cheek, James E. Holman, Robert C. Redd, John T. Haberling, Dana Hennessy, Thomas W. TI Infectious Disease Mortality Among American Indians and Alaska Natives, 1999-2009 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID UNITED-STATES; RESPIRATORY-TRACT; HOSPITALIZATIONS; TRENDS; POPULATION; CANCER; MISCLASSIFICATION; DISPARITIES; INFANTS; DEATH AB Objectives. We described death rates and leading causes of death caused by infectious diseases (IDs) in American Indian/Alaska Native (AI/AN) persons. Methods. We analyzed national mortality data, adjusted for AI/AN race by linkage with Indian Health Service registration records, for all US counties and Contract Health Service Delivery Area (CHSDA) counties. The average annual 1999 to 2009 ID death rates per 100 000 persons for AI/AN persons were compared with corresponding rates for Whites. Results. The ID death rate in AI/AN populations was significantly higher than that of Whites. A reported 8429 ID deaths (rate 86.2) in CHSDA counties occurred among AI/AN persons; the rate was significantly higher than the rate in Whites (44.0; rate ratio [RR] = 1.96; 95% confidence interval [CI] = 1.91, 2.00). The rates for the top 10 ID underlying causes of death were significantly higher for AI/AN persons than those for Whites. Lower respiratory tract infection and septicemia were the top-ranked causes. The greatest relative rate disparity was for tuberculosis (RR = 13.51; 95% CI = 11.36, 15.93). Conclusions. Health equity might be furthered by expansion of interventions to reduce IDs among AI/AN communities. C1 [Cheek, James E.] Univ New Mexico, Sch Med, Dept Family & Community Med, Albuquerque, NM 87131 USA. [Holman, Robert C.; Haberling, Dana] Ctr Dis Control & Prevent CDC, NCEZID, Atlanta, GA USA. [Redd, John T.] Indian Hlth Serv HIS, Santa Fe, NM USA. [Hennessy, Thomas W.] CDC, Arctic Invest Program, NCEZID, Anchorage, AK 99508 USA. RP Hennessy, TW (reprint author), CDC, Arctic Invest Program, 4055 Tudor Ctr Dr, Anchorage, AK 99508 USA. EM tbh0@cdc.gov NR 43 TC 2 Z9 2 U1 0 U2 3 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 SU 3 BP S446 EP S452 DI 10.2105/AJPH.2013.301721 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO5DL UT WOS:000341362300029 PM 24754622 ER PT J AU Cho, P Geiss, LS Burrows, NR Roberts, DL Bullock, AK Toedt, ME AF Cho, Pyone Geiss, Linda S. Burrows, Nilka Rios Roberts, Diana L. Bullock, Ann K. Toedt, Michael E. TI Diabetes-Related Mortality Among American Indians and Alaska Natives, 1990-2009 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID UNITED-STATES; DEATH CERTIFICATE; CANCER RATES; US ADULTS; PREVALENCE; TRENDS AB Objectives. We assessed diabetes-related mortality for American Indians and Alaska Natives (AI/ANs) and Whites. Methods. Study populations were non-Hispanic AI/AN and White persons in Indian Health Service (IHS) Contract Health Service Delivery Area counties; Hispanics were excluded. We used 1990 to 2009 death certificate data linked to IHS patient registration records to identify AI/AN decedents aged 20 years or older. We examined disparities and trends in mortality related to diabetes as an underlying cause of death (COD) and as a multiple COD. Results. After increasing between 1990 and 1999, rates of diabetes as an underlying COD and a multiple COD subsequently decreased in both groups. However, between 2000 and 2009, age-adjusted rates of diabetes as an underlying COD and a multiple COD remained 2.5 to 3.5 times higher among AI/AN persons than among Whites for all age groups (20-44, 45-54, 55-64, 65-74, and 75 years), both sexes, and every IHS region except Alaska. Conclusions. Declining trends in diabetes-related mortality in both AI/AN and White populations are consistent with recent improvements in their health status. Reducing persistent disparities in diabetes mortality will require developing effective approaches to not only control but also prevent diabetes among AI/AN populations. C1 [Cho, Pyone; Geiss, Linda S.; Burrows, Nilka Rios] Ctr Dis Control & Prevent CDC, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Roberts, Diana L.] Indian Hlth Serv IHS, Alaska Area Native Hlth Serv, Anchorage, AK USA. [Bullock, Ann K.] IHS, Div Diabet Treatment & Prevent, Albuquerque, NM USA. [Toedt, Michael E.] Cherokee Indian Hosp, Cherokee, NC USA. RP Cho, P (reprint author), Ctr Dis Control & Prevent, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,Mailstop F-73, Atlanta, GA 30341 USA. EM pcho@cdc.gov NR 47 TC 7 Z9 7 U1 2 U2 7 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 SU 3 BP S496 EP S503 DI 10.2105/AJPH.2014.301968 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO5DL UT WOS:000341362300035 PM 24754621 ER PT J AU Cobb, N Espey, D King, J AF Cobb, Nathaniel Espey, David King, Jessica TI Health Behaviors and Risk Factors Among American Indians and Alaska Natives, 2000-2010 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID NORTHERN PLAINS; UNITED-STATES; DISEASE; PREVALENCE AB Objectives. We provided contextual risk factor information for a special supplement on causes of death among American Indians and Alaska Natives (AI/ANs). We analyzed 11 years of Behavioral Risk Factor Surveillance System (BRFSS) data for AI/AN respondents in the United States. Methods. We combined BRFSS data from 2000 to 2010 to determine the prevalence of selected risk factors for AI/AN and White respondents residing in Indian Health Service Contract Health Service Delivery Area counties. Regional prevalence estimates for AI/AN respondents were compared with the estimates for White respondents for all regions combined; respondents of Hispanic origin were excluded. Results. With some regional exceptions, AI/AN people had high prevalence estimates of tobacco use, obesity, and physical inactivity, and low prevalence estimates of fruit and vegetable consumption, cancer screening, and seatbelt use. Conclusions. These behavioral risk factors were consistent with observed patterns of mortality and chronic disease among AI/AN persons. All are amenable to public health intervention. C1 [Cobb, Nathaniel] Indian Hlth Serv, Div Epidemiol & Dis Prevent, Albuquerque, NM USA. [Espey, David; King, Jessica] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA USA. RP Espey, D (reprint author), 1720 Louisiana Blvd NE, Albuquerque, NM 87110 USA. EM dke0@cdc.gov NR 36 TC 30 Z9 30 U1 3 U2 14 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 SU 3 BP S481 EP S489 DI 10.2105/AJPH.2014.301879 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO5DL UT WOS:000341362300033 PM 24754662 ER PT J AU Espey, DK Jim, MA Cobb, N Bartholomew, M Becker, T Haverkamp, D Plescia, M AF Espey, David K. Jim, Melissa A. Cobb, Nathaniel Bartholomew, Michael Becker, Tom Haverkamp, Don Plescia, Marcus TI Leading Causes of Death and All-Cause Mortality in American Indians and Alaska Natives SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID UNITED-STATES; METABOLIC SYNDROME; CANCER RATES; PREVALENCE; PATTERNS; TRENDS AB Objectives. We present regional patterns and trends in all-cause mortality and leading causes of death in American Indians and Alaska Natives (AI/ANs). Methods. US National Death Index records were linked with Indian Health Service (IHS) registration records to identify AI/AN deaths misclassified as non-AI/AN. We analyzed temporal trends for 1990 to 2009 and comparisons between non-Hispanic AI/AN and non-Hispanic White persons by geographic region for 1999 to 2009. Results focus on IHS Contract Health Service Delivery Area counties in which less race misclassification occurs. Results. From 1990 to 2009 AI/AN persons did not experience the significant decreases in all-cause mortality seen for Whites. For 1999 to 2009 the all-cause death rate in CHSDA counties for AI/AN persons was 46% more than that for Whites. Death rates for AI/AN persons varied as much as 50% among regions. Except for heart disease and cancer, subsequent ranking of specific causes of death differed considerably between AI/AN and White persons. Conclusions. AI/AN populations continue to experience much higher death rates than Whites. Patterns of mortality are strongly influenced by the high incidence of diabetes, smoking prevalence, problem drinking, and social determinants. Much of the observed excess mortality can be addressed through known public health interventions. C1 [Espey, David K.; Jim, Melissa A.; Haverkamp, Don; Plescia, Marcus] Ctr Dis Control & Prevent CDC, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Cobb, Nathaniel] Indian Hlth Serv, Div Epidemiol & Dis Prevent, Rockville, MD USA. [Becker, Tom] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. RP Espey, DK (reprint author), Div Epidemiol & Dis Prevent, 1720 Louisiana Blvd NE, Albuquerque, NM 87110 USA. EM dke0@cdc.gov NR 54 TC 31 Z9 31 U1 2 U2 16 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 SU 3 BP S303 EP S311 DI 10.2105/AJPH.2013.301798 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO5DL UT WOS:000341362300012 PM 24754554 ER PT J AU Groom, AV Hennessy, TW Singleton, RJ Butler, JC Holve, S Cheek, JE AF Groom, Amy V. Hennessy, Thomas W. Singleton, Rosalyn J. Butler, Jay C. Holve, Stephen Cheek, James E. TI Pneumonia and Influenza Mortality Among American Indian and Alaska Native People, 1990-2009 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID INVASIVE PNEUMOCOCCAL DISEASE; RESPIRATORY-TRACT INFECTION; WOOD-BURNING STOVES; UNITED-STATES; A H1N1; SYNCYTIAL VIRUS; RISK-FACTORS; POLYSACCHARIDE VACCINE; ETHNIC DISPARITIES; HEALTH BEHAVIORS AB Objectives. We compared pneumonia and influenza death rates among American Indian/Alaska Native (AI/AN) people with rates among Whites and examined geographic differences in pneumonia and influenza death rates for AI/AN persons. Methods. We adjusted National Vital Statistics Surveillance mortality data for racial misclassification of AI/AN people through linkages with Indian Health Service (IHS) registration records. Pneumonia and influenza deaths were defined as those who died from 1990 through 1998 and 1999 through 2009 according to codes for pneumonia and influenza from the International Classification of Diseases, 9th and 10th Revision, respectively. We limited the analysis to IHS Contract Health Service Delivery Area counties, and compared pneumonia and influenza death rates between AI/ANs and Whites by calculating rate ratios for the 2 periods. Results. Compared with Whites, the pneumonia and influenza death rate for AI/AN persons in both periods was significantly higher. AI/AN populations in the Alaska, Northern Plains, and Southwest regions had rates more than 2 times higher than those of Whites. The pneumonia and influenza death rate for AI/AN populations decreased from 39.6 in 1999 to 2003 to 33.9 in 2004 to 2009. Conclusions. Although progress has been made in reducing pneumonia and influenza mortality, disparities between AI/AN persons and Whites persist. Strategies to improve vaccination coverage and address risk factors that contribute to pneumonia and influenza mortality are needed. C1 [Groom, Amy V.] Ctr Dis Control & Prevent, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Hennessy, Thomas W.] Ctr Dis Control & Prevent, Arctic Invest Program, Natl Ctr Emerging & Zoonot Infect Dis, Anchorage, AK USA. [Singleton, Rosalyn J.; Butler, Jay C.] Alaska Native Tribal Hlth Consortium, Anchorage, AK USA. [Holve, Stephen] Indian Hlth Serv, Tuba City Reg Hlth Care, Tuba City, AZ USA. [Cheek, James E.] Univ New Mexico, Albuquerque, NM 87131 USA. RP Groom, AV (reprint author), MPH Native Diabet Wellness Program, 1720 Louisiana Blvd NE,Suite 208, Albuquerque, NM 87110 USA. EM Amy.Groom@ihs.gov NR 65 TC 7 Z9 7 U1 3 U2 6 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 SU 3 BP S460 EP S469 DI 10.2105/AJPH.2013.301740 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO5DL UT WOS:000341362300031 PM 24754620 ER PT J AU Hoffman, RM Li, J Henderson, JA Ajani, UA Wiggins, C AF Hoffman, Richard M. Li, Jun Henderson, Jeffrey A. Ajani, Umed A. Wiggins, Charles TI Prostate Cancer Deaths and Incident Cases Among American Indian/Alaska Native Men, 1999-2009 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID ALASKA-NATIVES; RADICAL PROSTATECTOMY; UNITED-STATES; NEW-MEXICO; FOLLOW-UP; INDIANS; MORTALITY; RATES; US; SURVEILLANCE AB Objectives. We linked databases to improve identification of American Indians/Alaska Natives (AI/ANs) in determining prostate cancer death and incidence rates. Methods. We linked prostate cancer mortality and incidence data with Indian Health Service (IHS) patient records; analyses focused on residents of IHS Contract Health Service Delivery Area (CHSDA) counties. We calculated age-adjusted incidence and death rates for AI/AN and White men for 1999 to 2009; men of Hispanic origin were excluded. Results. Prostate cancer death rates were higher for AI/AN men than for White men. Death rates declined for White men (-3.0% per year) but not for AI/AN men. AI/AN men had lower prostate cancer incidence rates than White men. Incidence rates declined among Whites (-2.2% per year) and AI/ANs (-1.9% per year). Conclusions. AI/AN men had higher prostate cancer death rates and lower prostate cancer incidence rates than White men. Disparities in accessing health care could contribute to mortality differences, and incidence differences could be related to lower prostate-specific antigen testing rates among AI/AN men. C1 [Hoffman, Richard M.; Wiggins, Charles] Univ New Mexico, Sch Med, Albuquerque, NM 87131 USA. [Hoffman, Richard M.; Wiggins, Charles] Univ New Mexico, Ctr Canc, Albuquerque, NM 87131 USA. [Hoffman, Richard M.] New Mexico VA Hlth Care Syst, Albuquerque, NM 87108 USA. [Li, Jun; Ajani, Umed A.] Ctr Dis Control & Prevent CDC, Atlanta, GA USA. [Henderson, Jeffrey A.] Black Hills Ctr Amer Indian Hlth, Rapid City, SD USA. RP Hoffman, RM (reprint author), New Mexico VA Hlth Care Syst, Mailstop 111,1501 San Pedro Dr SE, Albuquerque, NM 87108 USA. EM rhoffman@unm.edu FU US Department of Veterans Affairs; National Institutes of Health/National Institute of General Medical Sciences/Indian Health Service [1S06GM092240]; National Institutes of Health, National Cancer Institute [1P50CA148110] FX R. M. H. is supported by the US Department of Veterans Affairs. J. A. H. is supported by the National Institutes of Health/National Institute of General Medical Sciences/Indian Health Service (1S06GM092240) and the National Institutes of Health, National Cancer Institute (1P50CA148110). NR 42 TC 4 Z9 4 U1 0 U2 3 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 SU 3 BP S439 EP S445 DI 10.2105/AJPH.2013.301690 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO5DL UT WOS:000341362300028 PM 24754659 ER PT J AU Jim, MA Arias, E Seneca, DS Hoopes, MJ Jim, CC Johnson, NJ Wiggins, CL AF Jim, Melissa A. Arias, Elizabeth Seneca, Dean S. Hoopes, Megan J. Jim, Cheyenne C. Johnson, Norman J. Wiggins, Charles L. TI Racial Misclassification of American Indians and Alaska Natives by Indian Health Service Contract Health Service Delivery Area SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID END RESULTS PROGRAM; DEATH CERTIFICATES; UNITED-STATES; SURVEILLANCE DATA; CANCER REGISTRY; EPIDEMIOLOGY; RATES; ACCURACY; NATION; RACE AB Objectives. We evaluated the racial misclassification of American Indians and Alaska Natives (AI/ANs) in cancer incidence and all-cause mortality data by Indian Health Service (IHS) Contract Health Service Delivery Area (CHSDA). Methods. We evaluated data from 3 sources: IHS-National Vital Statistics System (NVSS), IHS-National Program of Cancer Registries (NPCR)/Surveillance, Epidemiology and End Results (SEER) program, and National Longitudinal Mortality Study (NLMS). We calculated, within each data source, the sensitivity and classification ratios by sex, IHS region, and urban-rural classification by CHSDA county. Results. Sensitivity was significantly greater in CHSDA counties (IHS-NVSS: 83.6%; IHS-NPCR/SEER: 77.6%; NLMS: 68.8%) than non-CHSDA counties (IHS-NVSS: 54.8%; IHS-NPCR/SEER: 39.0%; NLMS: 28.3%). Classification ratios indicated less misclassification in CHSDA counties (IHS-NVSS: 1.20%; IHS-NPCR/SEER: 1.29%; NLMS: 1.18%) than non-CHSDA counties (IHS-NVSS: 1.82%; IHS-NPCR/SEER: 2.56%; NLMS: 1.81%). Race misclassification was less in rural counties and in regions with the greatest concentrations of AI/AN persons (Alaska, Southwest, and Northern Plains). Conclusions. Limiting presentation and analysis to CHSDA counties helped mitigate the effects of race misclassification of AI/AN persons, although a portion of the population was excluded. C1 [Jim, Melissa A.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Albuquerque, NM USA. [Arias, Elizabeth] Ctr Dis Control & Prevent, Div Vital Stat, Natl Ctr Hlth Stat, Hyattsville, MD USA. [Seneca, Dean S.] Ctr Dis Control & Prevent, Div Publ Hlth Capac Dev, Off State Tribal Local & Terr Support, Atlanta, GA USA. [Hoopes, Megan J.] Northwest Portland Area Indian Hlth Board, Northwest Tribal Epidemiol Ctr, Portland, OR USA. [Jim, Cheyenne C.] Ctr Dis Control & Prevent, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Albuquerque, NM USA. [Johnson, Norman J.] US Bur Census, Natl Longitudinal Mortal Study Branch, Suitland, MD USA. [Wiggins, Charles L.] Univ New Mexico, Ctr Canc, New Mexico Tumor Registry, Albuquerque, NM 87131 USA. RP Jim, MA (reprint author), CDC, Div Canc Prevent & Control, Albuquerque, NM 87110 USA. EM melissa.jim@ihs.gov OI Hoopes, Megan/0000-0001-7941-254X NR 56 TC 24 Z9 24 U1 2 U2 8 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 SU 3 BP S295 EP S302 DI 10.2105/AJPH.2014.301933 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO5DL UT WOS:000341362300011 PM 24754617 ER PT J AU Li, J Weir, HK Jim, MA King, SM Wilson, R Master, VA AF Li, Jun Weir, Hannah K. Jim, Melissa A. King, Sallyann M. Wilson, Reda Master, Viraj A. TI Kidney Cancer Incidence and Mortality Among American Indians and Alaska Natives in the United States, 1990-2009 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID RENAL-CELL CANCER; PHYSICAL-ACTIVITY; HEALTH BEHAVIORS; RISING INCIDENCE; RISK-FACTORS; EPIDEMIOLOGY; PATTERNS; OBESITY; TRENDS; WOMEN AB Objectives. We describe rates and trends in kidney cancer incidence and mortality and identify disparities between American Indian/Alaska Native (AI/AN) and White populations. Methods. To improve identification of AI/AN race, incidence and mortality data were linked with Indian Health Service (IHS) patient records. Analysis focused on residents of IHS Contract Health Service Delivery Area counties; Hispanics were excluded. We calculated age-adjusted kidney cancer incidence (2001-2009) and death rates (1990-2009) by sex, age, and IHS region. Results. AI/AN persons have a 1.6 times higher kidney cancer incidence and a 1.9 times higher kidney cancer death rate than Whites. Despite a significant decline in kidney cancer death rates for Whites (annual percentage change [APC] = -0.3; 95% confidence interval [CI] = -0.5, 0.0), death rates for AI/AN persons remained stable (APC = 0.4; 95% CI = -0.7, 1.5). Kidney cancer incidence rates rose more rapidly for AI/AN persons (APC = 3.5; 95% CI = 1.2, 5.8) than for Whites (APC = 2.1; 95% CI = 1.4, 2.8). Conclusions. AI/AN individuals have greater risk of developing and dying of kidney cancers. Incidence rates have increased faster in AI/AN populations than in Whites. Death rates have decreased slightly in Whites but remained stable in AI/AN populations. Racial disparities in kidney cancer are widening. C1 [Li, Jun; Weir, Hannah K.; Jim, Melissa A.; Wilson, Reda] Ctr Dis Control & Prevent CDC, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [King, Sallyann M.] CDC, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Master, Viraj A.] Emory Univ, Sch Med, Dept Urol, Atlanta, GA USA. [Master, Viraj A.] Emory Univ, Sch Med, Winship Canc Inst, Atlanta, GA USA. RP Li, J (reprint author), CDC, Div Canc Prevent & Control, 4770 Buford Highway,MS K55, Atlanta, GA 30341 USA. EM ffa2@cdc.gov NR 44 TC 4 Z9 4 U1 0 U2 1 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 SU 3 BP S396 EP S403 DI 10.2105/AJPH.2013.301616 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO5DL UT WOS:000341362300023 PM 24754655 ER PT J AU Murphy, T Pokhrel, P Worthington, A Billie, H Sewell, M Bill, N AF Murphy, Tierney Pokhrel, Pallavi Worthington, Anne Billie, Holly Sewell, Mack Bill, Nancy TI Unintentional Injury Mortality Among American Indians and Alaska Natives in the United States, 1990-2009 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID OLDER PERSONS; DEATHS; POPULATIONS; OVERDOSES; FALLS AB Objectives. We describe the burden of unintentional injury (UI) deaths among American Indian and Alaska Native (AI/AN) populations in the United States. Methods. National Death Index records for 1990 to 2009 were linked with Indian Health Service registration records to identify AI/AN deaths misclassified as non-AI/AN deaths. Most analyses were restricted to Contract Health Service Delivery Area counties in 6 geographic regions of the United States. We compared age-adjusted death rates for AI/AN persons with those for Whites; Hispanics were excluded. Results. From 2005 to 2009, the UI death rate for AI/AN people was 2.4 times higher than for Whites. Death rates for the 3 leading causes of UI death-motor vehicle traffic crashes, poisoning, and falls-were 1.4 to 3 times higher among AI/AN persons than among Whites. UI death rates were higher among AI/AN males than among females and highest among AI/AN persons in Alaska, the Northern Plains, and the Southwest. Conclusions. AI/AN persons had consistently higher UI death rates than did Whites. This disparity in overall rates coupled with recent increases in unintentional poisoning deaths requires that injury prevention be a major priority for improving health and preventing death among AI/AN populations. C1 [Murphy, Tierney; Pokhrel, Pallavi; Worthington, Anne] New Mexico Dept Hlth, Epidemiol & Response Div, Santa Fe, NM 87502 USA. [Billie, Holly] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA. [Sewell, Mack] Wyoming Dept Workforce Serv, Cheyenne, WY USA. [Bill, Nancy] Indian Hlth Serv, Rockville, MD USA. RP Murphy, T (reprint author), New Mexico Dept Hlth, Epidemiol & Response Div, 1190 St Francis Dr,N1110,POB 26110, Santa Fe, NM 87502 USA. EM tierney.murphy@state.nm.us NR 43 TC 10 Z9 10 U1 0 U2 1 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 SU 3 BP S470 EP S480 DI 10.2105/AJPH.2013.301854 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO5DL UT WOS:000341362300032 PM 24754624 ER PT J AU Perdue, DG Haverkamp, D Perkins, C Daley, CM Provost, E AF Perdue, David G. Haverkamp, Donald Perkins, Carin Daley, Christine Makosky Provost, Ellen TI Geographic Variation in Colorectal Cancer Incidence and Mortality, Age of Onset, and Stage at Diagnosis Among American Indian and Alaska Native People, 1990-2009 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID UNITED-STATES; SURVEILLANCE; HEALTH; TRENDS; RATES; DISPARITIES AB Objectives. We characterized estimates of colorectal cancer (CRC) in American Indians/Alaska Natives (AI/ANs) compared with Whites using a linkage methodology to improve AI/AN classification in incidence and mortality data. Methods. We linked incidence and mortality data to Indian Health Service enrollment records. Our analyses were restricted to Contract Health Services Delivery Area counties. We analyzed death and incidence rates of CRC for AI/AN persons and Whites by 6 regions from 1999 to 2009. Trends were described using linear modeling. Results. The AI/AN colorectal cancer incidence was 21% higher and mortality 39% higher than in Whites. Although incidence and mortality significantly declined among Whites, AI/AN incidence did not change significantly, and mortality declined only in the Northern Plains. AI/AN persons had a higher incidence of CRC than Whites in all ages and were more often diagnosed with late stage CRC than Whites. Conclusions. Compared with Whites, AI/AN individuals in many regions had a higher burden of CRC and stable or increasing CRC mortality. An understanding of the factors driving these regional disparities could offer critical insights for prevention and control programs. C1 [Perdue, David G.] Amer Indian Canc Fdn, Minneapolis, MN USA. [Perdue, David G.] Minnesota Gastroenterol PA, Minneapolis, MN 55414 USA. [Haverkamp, Donald] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Perkins, Carin] Minnesota Canc Surveillance Syst, Minneapolis, MN USA. [Daley, Christine Makosky] Univ Kansas, Med Ctr, Ctr Amer Indian Community Hlth, Kansas City, KS USA. [Provost, Ellen] Alaska Native Tribal Hlth Consortium, Anchorage, AK USA. RP Perdue, DG (reprint author), Minnesota Gastroenterol PA, POB 14909, Minneapolis, MN 55414 USA. EM dperdue@mngastro.com NR 47 TC 12 Z9 12 U1 2 U2 5 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 SU 3 BP S404 EP S414 DI 10.2105/AJPH.2013.301654 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO5DL UT WOS:000341362300024 PM 24754657 ER PT J AU Plescia, M Henley, SJ Pate, A Underwood, JM Rhodes, K AF Plescia, Marcus Henley, Sarah Jane Pate, Anne Underwood, J. Michael Rhodes, Kris TI Lung Cancer Deaths Among American Indians and Alaska Natives, 1990-2009 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID CURRENT CIGARETTE-SMOKING; UNITED-STATES; TOBACCO CONTROL; MORTALITY; SURVEILLANCE; TRENDS; RATES; DISPARITIES; ADULTS; PATTERNS AB Objectives. We examined regional differences in lung cancer among American Indians/Alaska Natives (AI/ANs) using linked data sets to minimize racial misclassification. Methods. On the basis of federal lung cancer incidence data for 1999 to 2009 and deaths for 1990 to 2009 linked with Indian Health Service (IHS) registration records, we calculated age-adjusted incidence and death rates for non-Hispanic AI/AN and White persons by IHS region, focusing on Contract Health Service Delivery Area (CHSDA) counties. We correlated death rates with cigarette smoking prevalence and calculated mortality-to-incidence ratios. Results. Lung cancer death rates among AI/AN persons in CHSDA counties varied across IHS regions, from 94.0 per 100 000 in the Northern Plains to 15.2 in the Southwest, reflecting the strong correlation between smoking and lung cancer. For every 100 lung cancers diagnosed, there were 6 more deaths among AI/AN persons than among White persons. Lung cancer death rates began to decline in 1997 among AI/AN men and are still increasing among AI/AN women. Conclusions. Comparison of regional lung cancer death rates between AI/AN and White populations indicates disparities in tobacco control and prevention interventions. Efforts should be made to ensure that AI/AN persons receive equal benefit from current and emerging lung cancer prevention and control interventions. C1 [Plescia, Marcus; Henley, Sarah Jane; Underwood, J. Michael] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA USA. [Pate, Anne] Oklahoma Dept Hlth, Chron Dis Serv, Oklahoma City, OK USA. [Rhodes, Kris] Amer Indian Canc Fdn, Minneapolis, MN USA. RP Plescia, M (reprint author), 249 Billingsley Rd, Charlotte, NC 28211 USA. EM Marcus.Plescia@mecklenburgcountync.gov NR 50 TC 14 Z9 14 U1 2 U2 7 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 SU 3 BP S388 EP S395 DI 10.2105/AJPH.2013.301609 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO5DL UT WOS:000341362300022 PM 24754613 ER PT J AU Reilley, B Bloss, E Byrd, KK Iralu, J Neel, L Cheek, J AF Reilley, Brigg Bloss, Emily Byrd, Kathy K. Iralu, Jonathan Neel, Lisa Cheek, James TI Death Rates From Human Immunodeficiency Virus and Tuberculosis Among American Indians/Alaska Natives in the United States, 1990-2009 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID INFECTIOUS-DISEASE MORTALITY; ALASKA-NATIVES; ANTIRETROVIRAL THERAPY; RACIAL MISCLASSIFICATION; HIV INCIDENCE; RISK-FACTORS; HEALTH; HIV/AIDS; TRENDS; CANCER AB Objectives. We used race-corrected data and comprehensive diagnostic codes to better compare HIV and tuberculosis (TB) mortality from 1999 to 2009 between American Indian/Alaska Natives (AI/ANs) and Whites. Methods. National Vital Statistics Surveillance System mortality data were adjusted for AI/AN racial misclassification through linkage with Indian Health Service registration records. We compared average annual 1990 to 2009 HIV and TB death rates (per 100 000 people) for AI/AN persons with those for Whites; Hispanics were excluded. Results. Although death rates from HIV in AI/AN persons were significantly lower than those in Whites from 1990 to 1998 (4.2 vs 7.0), they were significantly higher than those in Whites from 1999 to 2009 (3.6 vs 2.0). Death rates from TB in AI/AN persons were significantly higher than those in Whites, with a significant disparity during both 1990 to 1998 (3.3 vs 0.3) and 1999 to 2009 (1.5 vs 0.1). Conclusions. The decrease in death rates from HIV and TB was greater among Whites, and death rates remained significantly higher among AI/AN individuals. Public health interventions need to be prioritized to reduce the TB and HIV burden and mortality in AI/AN populations. C1 [Reilley, Brigg; Iralu, Jonathan; Neel, Lisa] Indian Hlth Serv, Albuquerque, NM 87110 USA. [Bloss, Emily; Byrd, Kathy K.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Cheek, James] Univ New Mexico, Dept Family & Community Med, Albuquerque, NM 87131 USA. RP Reilley, B (reprint author), Indian Hlth Serv, 5300 Homestead Dr NE, Albuquerque, NM 87110 USA. EM Brigg.Reilley@ihs.gov NR 59 TC 2 Z9 2 U1 1 U2 4 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 SU 3 BP S453 EP S459 DI 10.2105/AJPH.2013.301746 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO5DL UT WOS:000341362300030 PM 24754664 ER PT J AU Schieb, LJ Ayala, C Valderrama, AL Veazie, MA AF Schieb, Linda J. Ayala, Carma Valderrama, Amy L. Veazie, Mark A. TI Trends and Disparities in Stroke Mortality by Region for American Indians and Alaska Natives SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID DISEASE RISK-FACTORS; FACTOR SURVEILLANCE SYSTEM; CARDIOVASCULAR-DISEASE; UNITED-STATES; HEART-ASSOCIATION; HEALTH BEHAVIORS; CANCER; CARE; POPULATIONS; CHALLENGES AB Objectives. We evaluated trends and disparities in stroke death rates for American Indians and Alaska Natives (AI/ANs) and White people by Indian Health Service region. Methods. We identified stroke deaths among AI/AN persons and Whites (adults aged 35 years or older) using National Vital Statistics System data for 1990 to 2009. We used linkages with Indian Health Service patient registration data to adjust for misclassification of race for AI/AN persons. Analyses excluded Hispanics and focused on Contract Health Service Delivery Area (CHSDA) counties. Results. Stroke death rates among AI/AN individuals were higher than among Whites for both men and women in CHSDA counties and were highest in the youngest age groups. Rates and AI/AN: White rate ratios varied by region, with the highest in Alaska and the lowest in the Southwest. Stroke death rates among AI/AN persons decreased in all regions beginning in 2001. Conclusions. Although stroke death rates among AI/AN populations have decreased over time, rates are still higher for AI/AN persons than for Whites. Interventions that address reducing stroke risk factors, increasing awareness of stroke symptoms, and increasing access to specialty care for stroke may be more successful at reducing disparities in stroke death rates. C1 [Schieb, Linda J.; Ayala, Carma; Valderrama, Amy L.] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA 30341 USA. [Veazie, Mark A.] Phoenix Area Indian Hlth Serv, Phoenix, AZ USA. RP Schieb, LJ (reprint author), Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, 4770 Buford Hwy NE,MS F-72, Atlanta, GA 30341 USA. EM lschieb@cdc.gov NR 54 TC 4 Z9 4 U1 0 U2 0 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 SU 3 BP S368 EP S376 DI 10.2105/AJPH.2013.301698 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO5DL UT WOS:000341362300020 PM 24754653 ER PT J AU Singh, SD Ryerson, AB Wu, MX Kaur, JS AF Singh, Simple D. Ryerson, A. Blythe Wu, Manxia Kaur, Judith S. TI Ovarian and Uterine Cancer Incidence and Mortality in American Indian and Alaska Native Women, United States, 1999-2009 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID INCIDENCE RATES; SURVEILLANCE; POPULATION; HEALTH; TRENDS; EPIDEMIOLOGY; HYSTERECTOMY; ETHNICITY; PATTERNS; REGISTRY AB Objectives. We examined geographic differences and trends in incidence and mortality of ovarian and uterine cancer in American Indian/Alaska Native (AI/AN) women. Methods. We linked mortality data (1990-2009) and incidence data (1999-2009) to Indian Health Service (IHS) records. Death (and incidence) rates for ovarian and uterine cancer were examined for AI/AN and White women; Hispanics were excluded. Analyses focused on Contract Health Service Delivery Area (CHSDA) counties. Results. AI/AN and White women had similar ovarian and uterine cancer death rates. Ovarian and uterine cancer incidence and death rates were higher for AI/ANs residing in CHSDA counties than for all US counties. We also observed geographic differences, regardless of CHSDA residence, in ovarian and uterine cancer incidence and death rates in AI/AN women by IHS region; Pacific Coast and Southern Plains women had higher ovarian cancer death rates and Northern Plains women had higher uterine cancer death rates. Conclusions. Regional differences in the incidence and mortality of ovarian and uterine cancers among AI/AN women in the United States were significant. More research among correctly classified AI/AN women is needed to understand these differences. C1 [Singh, Simple D.; Ryerson, A. Blythe; Wu, Manxia] Ctr Dis Control & Prevent, Canc Surveillance Branch, Div Canc Prevent & Control, Atlanta, GA USA. [Kaur, Judith S.] Mayo Clin, Dept Oncol, Rochester, MN USA. RP Singh, SD (reprint author), 4770 Buford Highway NE,Mailstop F-76, Atlanta, GA 30341 USA. EM hjv3@cdc.gov NR 57 TC 3 Z9 3 U1 1 U2 3 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 SU 3 BP S423 EP S431 DI 10.2105/AJPH.2013.301781 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO5DL UT WOS:000341362300026 PM 24754663 ER PT J AU Suryaprasad, A Byrd, KK Redd, JT Perdue, DG Manos, M McMahon, BJ AF Suryaprasad, Anil Byrd, Kathy K. Redd, John T. Perdue, David G. Manos, Michele McMahon, Brian J. TI Mortality Caused by Chronic Liver Disease Among American Indians and Alaska Natives in the United States, 1999-2009 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID HEPATITIS-C INFECTION; VIRUS-INFECTION; VIRAL-HEPATITIS; CANCER RATES; PREVALENCE; TRENDS; ADULTS; RISK; US AB Objectives. We compared chronic liver disease (CLD) mortality from 1999 to 2009 between American Indians and Alaska Natives (AI/ANs) and Whites in the United States after improving CLD case ascertainment and AI/AN race classification. Methods. We defined CLD deaths and causes by comprehensive death certificate-based diagnostic codes. To improve race classification, we linked US mortality data to Indian Health Service enrollment records, and we restricted analyses to Contract Health Service Delivery Areas and to non-Hispanic populations. We calculated CLD death rates (per 100 000) in 6 geographic regions. We then described trends using linear modeling. Results. CLD mortality increased from 1999 to 2009 in AI/AN persons and Whites. Overall, the CLD death rate ratio (RR) of AI/ANindividuals to Whites was 3.7 and varied by region. The RR was higher in women (4.7), those aged 25 to 44 years (7.4), persons residing in the Northern Plains (6.4), and persons dying of cirrhosis (4.0) versus hepatocellular carcinoma (2.5), particularly those aged 25 to 44 years (7.7). Conclusions. AI/AN persons had greater CLD mortality, particularly from premature cirrhosis, than Whites, with variable mortality by region. Comprehensive prevention and care strategies are urgently needed to stem the CLD epidemic among AI/AN individuals. C1 [Suryaprasad, Anil; Byrd, Kathy K.] Ctr Dis Control & Prevent CDC, Div Viral Hepatitis, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, US Dept HHS, Atlanta, GA 30329 USA. [Redd, John T.] Santa Fe Publ Hlth Serv Indian, Indian Hlth Serv, US Dept Hlth & Human Serv, Santa Fe, NM USA. [Perdue, David G.] Amer Indian Canc Fdn, Minneapolis, MN USA. [Perdue, David G.] Minnesota Gastroenterol PA, Minneapolis, MN USA. [Manos, Michele] Kaiser Permanente, Div Res, Oakland, CA USA. [McMahon, Brian J.] Ctr Dis Control & Prevent, Arctic Invest Program, Div Preparedness & Emerging Infect, Natl Ctr Emerging & Zoonot Infect Dis, Anchorage, AK USA. RP Suryaprasad, A (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, 1600 Clifton Rd NE,Mailstop G-37, Atlanta, GA 30329 USA. EM asuryaprasad@cdc.gov FU Centers for Disease Control and Prevention (CDC); Indian Health Service (IHS) FX This study was supported by the Centers for Disease Control and Prevention (CDC) and the Indian Health Service (IHS). NR 43 TC 7 Z9 7 U1 0 U2 1 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 SU 3 BP S350 EP S358 DI 10.2105/AJPH.2013.301645 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO5DL UT WOS:000341362300018 PM 24754616 ER PT J AU Veazie, M Ayala, C Schieb, L Dai, SF Henderson, JA Cho, P AF Veazie, Mark Ayala, Carma Schieb, Linda Dai, Shifan Henderson, Jeffrey A. Cho, Pyone TI Trends and Disparities in Heart Disease Mortality Among American Indians/Alaska Natives, 1990-2009 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID ALASKA-NATIVES; CARDIOVASCULAR-DISEASE; UNITED-STATES; CANCER; DEATH; PREVALENCE; QUALITY; RATES AB Objectives. We evaluated heart disease death rates among American Indians and Alaska Natives (AI/ANs) and Whites after improving identification of AI/AN populations. Methods. Indian Health Service (IHS) registration data were linked to the National Death Index for 1990 to 2009 to identify deaths among AI/AN persons aged 35 years and older with heart disease listed as the underlying cause of death (UCOD) or 1 of multiple causes of death (MCOD). We restricted analyses to IHS Contract Health Service Delivery Areas and to non-Hispanic populations. Results. Heart disease death rates were higher among AI/AN persons than Whites from 1999 to 2009 (1.21 times for UCOD, 1.30 times for MCOD). Disparities were highest in younger age groups and in the Northern Plains, but lowest in the East and Southwest. In AI/AN persons, MCOD rates were 84% higher than UCOD rates. From 1990 to 2009, UCOD rates declined among Whites, but only declined significantly among AI/AN persons after 2003. Conclusions. Analysis with improved race identification indicated that AI/AN populations experienced higher heart disease death rates than Whites. Better prevention and more effective care of heart disease is needed for AI/AN populations. C1 [Veazie, Mark] Phoenix Area Indian Hlth Serv, Flagstaff, AZ USA. [Ayala, Carma; Schieb, Linda] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA USA. [Dai, Shifan] Ctr Dis Control & Prevent, Div Nutr & Phys Act, Atlanta, GA USA. [Henderson, Jeffrey A.] Black Hills Ctr Amer Indian Hlth, Rapid City, SD USA. [Cho, Pyone] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA USA. RP Veazie, M (reprint author), 1215 N Beaver St Suite 201, Flagstaff, AZ 86001 USA. EM mark.veazie@ihs.gov FU National Institutes of Health [1S06GM092240, 1P50CA148110] FX J. H.'s contribution was supported by the National Institutes of Health (grants 1S06GM092240 [NIH/NIGMS/IHS] and 1P50CA148110 [NIH/NCI]). NR 48 TC 10 Z9 10 U1 2 U2 5 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 SU 3 BP S359 EP S367 DI 10.2105/AJPH.2013.301715 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO5DL UT WOS:000341362300019 PM 24754556 ER PT J AU Watson, M Benard, V Thomas, C Brayboy, A Paisano, R Becker, T AF Watson, Meg Benard, Vicki Thomas, Cheryll Brayboy, Annie Paisano, Roberta Becker, Thomas TI Cervical Cancer Incidence and Mortality Among American Indian and Alaska Native Women, 1999-2009 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID UNITED-STATES; HUMAN-PAPILLOMAVIRUS; VACCINATION COVERAGE; HEALTH-SERVICE; RATES; PATTERNS; SURVEILLANCE; PROGRAM; TRENDS AB Objectives. We analyzed cervical cancer incidence and mortality data in American Indian and Alaska Native (AI/AN) women compared with women of other races. Methods. We improved identification of AI/AN race, cervical cancer incidence, and mortality data using Indian Health Service (IHS) patient records; our analyses focused on residents of IHS Contract Health Service Delivery Area (CHSDA) counties. Age-adjusted incidence and death rates were calculated for AI/AN and White women from 1999 to 2009. Results. AI/AN women in CHSDA counties had a death rate from cervical cancer of 4.2, which was nearly twice the rate in White women (2.0; rate ratio [RR] = 2.11). AI/AN women also had higher incidence rates of cervical cancer compared with White women (11.0 vs 7.1; RR = 1.55) and were more often diagnosed with later-stage disease (RR = 1.84 for regional stage and RR = 1.74 for distant stage). Death rates decreased for AI/AN women from 1990 to 1993 (-25.8%/year) and remained stable thereafter. Conclusions. Although rates decreased over time, AI/AN women had disproportionately higher cervical cancer incidence and mortality. The persistently higher rates among AI/AN women compared with White women require continued improvements in identifying and treating cervical cancer and precancerous lesions. C1 [Watson, Meg; Benard, Vicki; Thomas, Cheryll; Brayboy, Annie] Ctr Dis Control & Prevent CDC, Div Canc Prevent & Control, Atlanta, GA USA. [Paisano, Roberta] Indian Hlth Serv, Albuquerque, NM USA. [Becker, Thomas] Oregon Hlth & Sci Univ, Sch Med, Dept Publ Hlth & Prevent Med, Portland, OR 97201 USA. RP Watson, M (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, 4770 Buford Hwy,MS-F76, Atlanta, GA 30341 USA. EM EZE5@cdc.gov NR 53 TC 11 Z9 11 U1 0 U2 2 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 SU 3 BP S415 EP S422 DI 10.2105/AJPH.2013.301681 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO5DL UT WOS:000341362300025 PM 24754650 ER PT J AU White, A Richardson, LC Li, CY Ekwueme, DU Kaur, JS AF White, Arica Richardson, Lisa C. Li, Chunyu Ekwueme, Donatus U. Kaur, Judith S. TI Breast Cancer Mortality Among American Indian and Alaska Native Women, 1990-2009 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID UNITED-STATES; RATES; DISPARITIES; SURVIVAL; PATTERNS; PROGRAM; TRENDS; US AB Objectives. We compared breast cancer death rates and mortality trends among American Indian/Alaska Native (AI/AN) and White women using data for which racial misclassification was minimized. Methods. We used breast cancer deaths and cases linked to Indian Health Service (IHS) data to calculate age-adjusted rates and 95% confidence intervals (CIs) by IHS-designated regions from 1990 to 2009 for AI/AN and White women; Hispanics were excluded. Mortality-to-incidence ratios (MIR) were calculated for 1999 to 2009 as a proxy for prognosis after diagnosis. Results. Overall, the breast cancer death rate was lower in AI/AN women (21.6 per 100 000) than in White women (26.5). However, rates in AI/ANs were higher than rates in Whites for ages 40 to 49 years in the Alaska region, and ages 65 years and older in the Southern Plains region. White death rates significantly decreased (annual percent change [APC] = -2.1; 95% CI = -2.3, -2.0), but regional and overall AI/AN rates were unchanged (APC = 0.9; 95% CI = 0.1, 1.7). AI/AN women had higher MIRs than White women. Conclusions. There has been no improvement in death rates among AI/AN women. Targeted screening and timely, high-quality treatment are needed to reduce mortality from breast cancer in AI/AN women. C1 [White, Arica; Richardson, Lisa C.; Li, Chunyu; Ekwueme, Donatus U.] Ctr Dis Control & Prevent CDC, Div Canc Prevent & Control, Natl Ctr Chron Dis & Hlth Promot, Atlanta, GA USA. [Kaur, Judith S.] Mayo Clin, Rochester, MN USA. RP White, A (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, Epidemiol & Appl Res Branch, 4770 Buford Hwy NE,Mailstop F76, Atlanta, GA 30341 USA. EM awhite5@cdc.gov NR 34 TC 8 Z9 8 U1 2 U2 4 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 SU 3 BP S432 EP S438 DI 10.2105/AJPH.2013.301720 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO5DL UT WOS:000341362300027 PM 24754658 ER PT J AU White, MC Espey, DK Swan, J Wiggins, CL Eheman, C Kaur, JS AF White, Mary C. Espey, David K. Swan, Judith Wiggins, Charles L. Eheman, Christie Kaur, Judith S. TI Disparities in Cancer Mortality and Incidence Among American Indians and Alaska Natives in the United States SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID EARLY-DETECTION PROGRAM; END RESULTS PROGRAM; TO-INCIDENCE RATIOS; UNDERSERVED WOMEN; NATIONAL BREAST; SCREENING NEEDS; HEPATITIS-B; HEALTH; SURVEILLANCE; POPULATION AB Objectives. We used improved data on American Indian and Alaska Native (AI/AN) ancestry to provide an updated and comprehensive description of cancer mortality and incidence among AI/AN populations from 1990 to 2009. Methods. We linked the National Death Index and central cancer registry records independently to the Indian Health Service (IHS) patient registration database to improve identification of AI/AN persons in cancer mortality and incidence data, respectively. Analyses were restricted to non-Hispanic persons residing in Contract Health Service Delivery Area counties in 6 geographic regions of the United States. We compared age-adjusted mortality and incidence rates for AI/AN populations with White populations using rate ratios and mortality-to-incidence ratios. Trends were described using joinpoint analysis. Results. Cancer mortality and incidence rates for AI/AN persons compared with Whites varied by region and type of cancer. Trends in death rates showed that greater progress in cancer control was achieved for White populations compared with AI/AN populations over the last 2 decades. Conclusions. Spatial variations in mortality and incidence by type of cancer demonstrated both persistent and emerging challenges for cancer control in AI/AN populations. C1 [White, Mary C.; Espey, David K.; Eheman, Christie] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA USA. [Swan, Judith] NCI, Surveillance Res Program, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. [Wiggins, Charles L.] Univ New Mexico, Ctr Canc, New Mexico Tumor Registry, Albuquerque, NM 87131 USA. [Kaur, Judith S.] Mayo Clin, Native Amer Programs, Rochester, MN USA. RP White, MC (reprint author), CDC, Epidemiol & Appl Res Branch, Div Canc Prevent & Control, 4770 Buford Highway NE,F76, Atlanta, GA 30341 USA. EM mxw5@cdc.gov RI White, Mary /C-9242-2012 OI White, Mary /0000-0002-9826-3962 FU National Cancer Institute (NCI), National Institutes of Health [HHSN261201000033C]; University of New Mexico Cancer Center [P30-CA118100] FX C. L. Wiggins received support under contract HHSN261201000033C from the National Cancer Institute (NCI), National Institutes of Health and from the University of New Mexico Cancer Center, as a recipient of NCI Cancer Support Grant P30-CA118100. NR 61 TC 27 Z9 27 U1 2 U2 9 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 SU 3 BP S377 EP S387 DI 10.2105/AJPH.2013.301673 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO5DL UT WOS:000341362300021 PM 24754660 ER PT J AU Wong, CA Gachupin, FC Holman, RC MacDorman, MF Cheek, JE Holve, S Singleton, RJ AF Wong, Charlene A. Gachupin, Francine C. Holman, Robert C. MacDorman, Marian F. Cheek, James E. Holve, Steve Singleton, Rosalyn J. TI American Indian and Alaska Native Infant and Pediatric Mortality, United States, 1999-2009 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID INFECTIOUS-DISEASE HOSPITALIZATIONS; AGED 0-19 YEARS; RISK-FACTORS; RESPIRATORY-TRACT; POSTNEONATAL MORTALITY; UNINTENTIONAL INJURY; DEATH-SYNDROME; SUBSTANCE USE; HEALTH; CHILDREN AB Objectives. We described American Indian/Alaska Native (AI/AN) infant and pediatric death rates and leading causes of death. Methods. We adjusted National Vital Statistics System mortality data for AI/AN racial misclassification by linkage with Indian Health Service (IHS) registration records. We determined average annual death rates and leading causes of death for 1999 to 2009 for AI/AN versus White infants and children. We limited the analysis to IHS Contract Health Service Delivery Area counties. Results. The AI/AN infant death rate was 914 (rate ratio [RR] = 1.61; 95% confidence interval [CI] = 1.55, 1.67). Sudden infant death syndrome, unintentional injuries, and influenza or pneumonia were more common in AI/AN versus White infants. The overall AI/AN pediatric death rates were 69.6 for ages 1 to 4 years (RR = 2.56; 95% CI = 2.38, 2.75), 28.9 for ages 5 to 9 years (RR = 2.12; 95% CI = 1.92, 2.34), 37.3 for ages 10 to 14 years (RR = 2.22; 95% CI = 2.04, 2.40), and 158.4 for ages 15 to 19 years (RR = 2.71; 95% CI = 2.60, 2.82). Unintentional injuries and suicide occurred at higher rates among AI/AN youths versus White youths. Conclusions. Death rates for AI/AN infants and children were higher than for Whites, with regional disparities. Several leading causes of death in the AI/AN pediatric population are potentially preventable. C1 [Wong, Charlene A.] Univ Washington, Dept Pediat, Seattle Childrens Hosp, Seattle, WA 98195 USA. [Gachupin, Francine C.] Univ Arizona, Coll Med, Dept Family & Community Med, Tucson, AZ USA. [Holman, Robert C.] Ctr Dis Control & Prevent CDC, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. [MacDorman, Marian F.] Natl Ctr Hlth Stat, Reprod Stat Branch, Div Vital Stat, Hyattsville, MD 20782 USA. [Cheek, James E.] Univ New Mexico, Sch Med, Publ Hlth Program, Dept Family & Community Med, Albuquerque, NM 87131 USA. [Holve, Steve] Tuba City Reg Healthcare Corp, Indian Hlth Serv, Tuba City, AZ USA. [Singleton, Rosalyn J.] CDC, Arctic Invest Program, Div Preparedness & Emerging Infect, Natl Ctr Emerging & Zoonot Infect Dis, Anchorage, AK USA. RP Wong, CA (reprint author), Univ Penn, Robert Wood Johnson Fdn Clin Scholars Program, 1303 Blockley Hall,423 Guardian Dr, Philadelphia, PA 19104 USA. EM charwong@upenn.edu NR 70 TC 9 Z9 9 U1 1 U2 7 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 2014 VL 104 SU 3 BP S320 EP S328 DI 10.2105/AJPH.2013.301598 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AO5DL UT WOS:000341362300014 PM 24754619 ER PT J AU Ponder-Brookins, P Witt, J Steward, J Greenwell, D Chew, GL Samuel, Y Kennedy, C Brown, MJ AF Ponder-Brookins, Paris Witt, Joyce Steward, John Greenwell, Douglas Chew, Ginger L. Samuel, Yvette Kennedy, Chinaro Brown, Mary Jean TI Incorporating Community-Based Participatory Research Principles Into Environmental Health Research: Challenges and Lessons Learned From a Housing Pilot Study SO JOURNAL OF ENVIRONMENTAL HEALTH LA English DT Article ID PARTNERSHIP; EXPOSURE; SEATTLE; PROJECT; ASTHMA; HOME AB In environmental health research, a community-based participatory research (CBPR) approach can effectively involve community members, researchers, and representatives from nonprofit, academic, and governmental agencies as equal partners throughout the research process. The authors sought to use CBPR principles in a pilot study; its purpose was to investigate how green construction practices might affect indoor exposures to chemicals and biological agents. Information from this pilot informed the development of a methodology for a nationwide study of low-income urban multifamily housing. The authors describe here 1) the incorporation of CBPR principles into a pilot study comparing green vs. conventionally built urban housing, 2) the resulting implementation and reporting challenges, and 3) lessons learned and implications for increased community participation in environmental health research. C1 [Ponder-Brookins, Paris; Witt, Joyce; Chew, Ginger L.; Kennedy, Chinaro; Brown, Mary Jean] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Steward, John] Georgia State Univ, Sch Publ Hlth, Atlanta, GA 30303 USA. [Greenwell, Douglas] Atlanta Reg Hlth Forum, Atlanta, GA USA. [Samuel, Yvette] ZAP Asthma, Atlanta, GA USA. RP Ponder-Brookins, P (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop D-29, Atlanta, GA 30333 USA. EM fpd6@cdc.gov NR 27 TC 1 Z9 1 U1 1 U2 4 PU NATL ENVIRON HEALTH ASSOC PI DENVER PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA SN 0022-0892 J9 J ENVIRON HEALTH JI J. Environ. Health PD JUN PY 2014 VL 76 IS 10 BP 8 EP 17 PG 10 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AO7NU UT WOS:000341540700002 PM 24988659 ER PT J AU Anderson, DJ Podgorny, K Berrios-Torres, SI Bratzler, DW Dellinger, EP Greene, L Nyquist, AC Saiman, L Yokoe, DS Maragakis, LL Kaye, KS AF Anderson, Deverick J. Podgorny, Kelly Berrios-Torres, Sandra I. Bratzler, Dale W. Dellinger, E. Patchen Greene, Linda Nyquist, Ann-Christine Saiman, Lisa Yokoe, Deborah S. Maragakis, Lisa L. Kaye, Keith S. TI Strategies to Prevent Surgical Site Infections in Acute Care Hospitals: 2014 Update SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID RESISTANT STAPHYLOCOCCUS-AUREUS; RANDOMIZED CONTROLLED-TRIAL; STERNAL WOUND INFECTIONS; GENTAMICIN-COLLAGEN SPONGE; BYPASS GRAFT-SURGERY; SUPPLEMENTAL PERIOPERATIVE OXYGEN; TOTAL PARENTERAL-NUTRITION; TRICLOSAN-COATED SUTURES; TOTAL HIP-ARTHROPLASTY; OPEN-HEART-SURGERY C1 [Anderson, Deverick J.] Duke Univ, Med Ctr, Durham, NC 27710 USA. [Podgorny, Kelly] Int Joint Commiss, Oak Brook Terrace, IL USA. [Berrios-Torres, Sandra I.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Bratzler, Dale W.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA. [Dellinger, E. Patchen] Univ Washington, Med Ctr, Seattle, WA 98195 USA. [Greene, Linda] Highland Hosp, Rochester, NY USA. [Greene, Linda] Univ Rochester, Med Ctr, Rochester, NY 14642 USA. [Nyquist, Ann-Christine] Childrens Hosp Colorado, Aurora, CO USA. [Nyquist, Ann-Christine] Univ Colorado, Sch Med, Aurora, CO USA. [Saiman, Lisa] Columbia Univ, Med Ctr, New York, NY USA. [Yokoe, Deborah S.] Brigham & Womens Hosp, Boston, MA 02115 USA. [Yokoe, Deborah S.] Harvard Univ, Sch Med, Boston, MA USA. [Maragakis, Lisa L.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Kaye, Keith S.] Detroit Med Ctr, Detroit, MI USA. [Kaye, Keith S.] Wayne State Univ, Detroit, MI USA. RP Anderson, DJ (reprint author), Duke Univ, Med Ctr, Div Infect Dis, Box 102359, Durham, NC 27710 USA. EM deverick.anderson@duke.edu FU Tetraphase; Sage Products FX E.P.D. reports serving as an advisor/consultant for Merck, Baxter, Ortho-McNeil, Targanta, Rib-X, Affinium, 3M, Schering-Plough, Astellas, CareFusion, Durata, Pfizer, and Applied Medical and receiving grant support from Tetraphase. L.G. reports receiving honoraria from Premier, CareFusion, and Infection Control Today. K.S.K. reports receiving grant support and serving as an advisor/consultant for Sage Products. D.J.A., K.P., D.W.B., S.I.B.-T., A.-C.N., L.L.M., L.S., and D.S.Y. report no relevant conflicts of interest. NR 233 TC 0 Z9 0 U1 1 U2 7 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X EI 1559-6834 J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD JUN 1 PY 2014 VL 35 IS 6 BP 605 EP 627 DI 10.1086/676022 PG 23 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AG8UK UT WOS:000335693500001 ER PT J AU Dubberke, ER Carling, P Carrico, R Donskey, CJ Loo, VG McDonald, LC Maragakis, LL Sandora, TJ Weber, DJ Yokoe, DS Gerding, DN AF Dubberke, Erik R. Carling, Philip Carrico, Ruth Donskey, Curtis J. Loo, Vivian G. McDonald, L. Clifford Maragakis, Lisa L. Sandora, Thomas J. Weber, David J. Yokoe, Deborah S. Gerding, Dale N. TI Strategies to Prevent Clostridium difficile Infections in Acute Care Hospitals: 2014 Update SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID RESISTANT STAPHYLOCOCCUS-AUREUS; HIGH-RISK ANTIBIOTICS; ENVIRONMENTAL CONTAMINATION; HYPOCHLORITE SOLUTION; COLONIZED PATIENTS; CONTACT ISOLATION; TOXIN PRODUCTION; ISOLATION ROOMS; UNITED-STATES; NORTH-AMERICA C1 [Dubberke, Erik R.] Washington Univ, Sch Med, St Louis, MO 63110 USA. [Carling, Philip] Boston Univ, Sch Med, Boston, MA 02118 USA. [Carrico, Ruth] Univ Louisville, Sch Med, Div Infect Dis, Louisville, KY 40292 USA. [Donskey, Curtis J.] Case Western Reserve Univ, Louis Stokes Cleveland Vet Affairs Med Ctr, Cleveland, OH 44106 USA. [Loo, Vivian G.] McGill Univ, McGill Univ Hlth Ctr, Montreal, PQ, Canada. [McDonald, L. Clifford] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA. [Maragakis, Lisa L.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Sandora, Thomas J.] Harvard Univ, Sch Med, Boston Childrens Hosp, Boston, MA USA. [Weber, David J.] Univ N Carolina, Sch Med, Chapel Hill, NC USA. [Yokoe, Deborah S.] Brigham & Womens Hosp, Boston, MA 02115 USA. [Yokoe, Deborah S.] Harvard Univ, Sch Med, Boston, MA USA. [Gerding, Dale N.] Edward Hines Jr Vet Affairs Hosp, Hines, IL USA. [Gerding, Dale N.] Loyola Univ, Stritch Sch Med, Chicago, IL 60611 USA. RP Dubberke, ER (reprint author), Washington Univ, Sch Med, 660 South Euclid Ave,Box 8051, St Louis, MO 63110 USA. EM edubberk@dom.wustl.edu FU Sanofi Pasteur; ViroPharma; Optimer; Merck; Rebiotix; Steris; Pfizer; GOJO Industries FX E.R.D. reports serving as an advisor/consultant for Sanofi Pasteur, Merck, and Pfizer and receiving research grants/contracts from Sanofi Pasteur, ViroPharma, Optimer, Merck, and Rebiotix. P.C. reports serving as an advisor/consultant for Steris and holding a patent/copyright/license with Ecolab. R.C. reports serving on the speakers' bureau for Sanofi Pasteur, MedImmune, Abbott Diabetes Care, and 3M; performing technical writing for Ketchum; and receiving research grants/contracts from Sanofi Pasteur. C.J.D. reports serving as an advisor/consultant for Steris, GOJO Industries, and 3M; receiving honoraria from Ecolab; and receiving research grants/contracts from Merck, ViroPharma, Steris, and Pfizer. V.G.L. reports serving as an advisor/consultant for Optimer Pharmaceuticals. D.J.W. reports serving as an advisor/consultant for Johnson & Johnson and Clorox. D.N.G. reports serving as an advisor/consultant for Merck, Cubist, Novartis, Cangene, Actelion, ViroPharma, Rebiotix, and Sanofi Pasteur; receiving honoraria from Robert Michael; holding a patent/license (no royalties) with ViroPharma; and receiving research grant/contracts from GOJO Industries. L.C.M., L.L.M., T.J.S., and D.S.Y. report no conflicts of interest. NR 122 TC 0 Z9 0 U1 2 U2 3 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X EI 1559-6834 J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD JUN 1 PY 2014 VL 35 IS 6 BP 628 EP 645 DI 10.1086/676023 PG 18 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AG8UK UT WOS:000335693500002 ER PT J AU Sanchez, GV Hicks, LA AF Sanchez, Guillermo V. Hicks, Lauri A. TI Acute Sinusitis and Pharyngitis as Inappropriate Indications for Antibiotic Use SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Letter ID CLINICAL-PRACTICE GUIDELINE; RHINOSINUSITIS; CHILDREN; ADULTS C1 [Sanchez, Guillermo V.; Hicks, Lauri A.] Ctr Dis Control & Prevent, Get Smart Know Antibiot Work Program, Atlanta, GA 30333 USA. RP Sanchez, GV (reprint author), Ctr Dis Control & Prevent, Get Smart Know Antibiot Work Program, Atlanta, GA 30333 USA. EM xkv4@cdc.gov NR 4 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JUN PY 2014 VL 58 IS 6 BP 3572 EP 3572 DI 10.1128/AAC.02696-14 PG 1 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA AK9VP UT WOS:000338776900081 PM 24829387 ER PT J AU Stoddard, RA Quinn, CP Schiffer, JM Boyer, AE Goldstein, J Bagarozzi, DA Soroka, SD Dauphin, LA Hoffmaster, AR AF Stoddard, Robyn A. Quinn, Conrad P. Schiffer, Jarad M. Boyer, Anne E. Goldstein, Jason Bagarozzi, Dennis A. Soroka, Stephen D. Dauphin, Leslie A. Hoffmaster, Alex R. TI Detection of anthrax protective antigen (PA) using europium labeled anti-PA monoclonal antibody and time-resolved fluorescence SO JOURNAL OF IMMUNOLOGICAL METHODS LA English DT Article DE Bacillus anthracis; Protective antigen; Anthrax toxin; Europium; Immunoassays; Time resolved fluorescence ID LINKED-IMMUNOSORBENT-ASSAY; INHALATION ANTHRAX; LETHAL FACTOR; BACILLUS-ANTHRACIS; MASS-SPECTROMETRY; IMMUNOGLOBULIN-G; TOXIN; MODEL; BINDING; MARKER AB Inhalation anthrax is a rare but acute infectious disease following adsorption of Bacillus anthracis spores through the lungs. The disease has a high fatality rate if untreated, but early and correct diagnosis has a significant impact on case patient recovery. The early symptoms of inhalation anthrax are, however, non-specific and current anthrax diagnostics are primarily dependent upon culture and confirmatory real-time PCR. Consequently, there may be a significant delay in diagnosis and targeted treatment. Rapid, culture-independent diagnostic tests are therefore needed, particularly in the context of a large scale emergency response. The aim of this study was to evaluate the ability of monoclonal antibodies to detect anthrax toxin proteins that are secreted early in the course of B. anthracis infection using a time-resolved fluorescence (TRF) immunoassay. We selected monoclonal antibodies that could detect protective antigen (PA), as PA83 and also PA63 and LF in the lethal toxin complex. The assay reliable detection limit (RDL) was 6.63 x 10(-6) mu M (0.551 ng/ml) for PA83 and 2.51 x 10(-5) mu M (1.58 ng/ml) for PA63. Despite variable precision and accuracy of the assay, PA was detected in 9 out of 10 sera samples from anthrax confirmed case patients with cutaneous (n = 7), inhalation (n = 2), and gastrointestinal (n = 1) disease. Anthrax Immune Globulin (AIG), which has been used in treatment of clinical anthrax, interfered with detection of PA. This study demonstrates a culture-independent method of diagnosing anthrax through the use of monoclonal antibodies to detect PA and LF in the lethal toxin complex. Published by Elsevier B.V. C1 [Stoddard, Robyn A.; Quinn, Conrad P.; Schiffer, Jarad M.; Boyer, Anne E.; Goldstein, Jason; Bagarozzi, Dennis A.; Soroka, Stephen D.; Dauphin, Leslie A.; Hoffmaster, Alex R.] CDC, Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Stoddard, RA (reprint author), Ctr Dis Control & Prevent, Div High Consequence Pathogens & Pathol, Bacterial Special Pathogens Branch, Zoonoses & Select Agent Lab, Mail Stop G-34,1600 Clifton Rd, Atlanta, GA 30333 USA. EM RAStoddard@cdc.gov FU Biomedical Advanced Research and Development Authority (BARDA) FX The authors would like to thank Hanan Dababneh, Panagiotis Maniatis, Maribel Gallegos Candela, Renato C. Lins, and John R. Barr for their assistance with sample testing and reagent acquisition; Todd Parker and Elke Saile for their technical assistance; and Yon Yu for reviewing the manuscript. A portion of this work was funded by a Biomedical Advanced Research and Development Authority (BARDA) interagency agreement. NR 29 TC 6 Z9 6 U1 0 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1759 EI 1872-7905 J9 J IMMUNOL METHODS JI J. Immunol. Methods PD JUN PY 2014 VL 408 BP 78 EP 88 DI 10.1016/j.jim.2014.05.008 PG 11 WC Biochemical Research Methods; Immunology SC Biochemistry & Molecular Biology; Immunology GA AM0JU UT WOS:000339532700009 PM 24857756 ER PT J AU Savic, RM Lu, YH Bliven-Sizemore, E Weiner, M Nuermberger, E Burman, W Dorman, SE Dooley, KE AF Savic, Radojka M. Lu, Yanhui Bliven-Sizemore, Erin Weiner, Marc Nuermberger, Eric Burman, William Dorman, Susan E. Dooley, Kelly E. TI Population Pharmacokinetics of Rifapentine and Desacetyl Rifapentine in Healthy Volunteers: Nonlinearities in Clearance and Bioavailability SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PULMONARY TUBERCULOSIS; MYCOBACTERIUM-TUBERCULOSIS; BACTERICIDAL ACTIVITY; RIFAMPIN; MODEL; DISPOSITION; METABOLISM; ABSORPTION; RIFAMYCINS; MG AB Rifapentine is under active investigation as a potent drug that may help shorten the tuberculosis (TB) treatment duration. A previous rifapentine dose escalation study with daily dosing indicated a possible decrease in bioavailability as the dose increased and an increase in clearance over time for rifapentine and its active metabolite, desacetyl rifapentine. This study aimed to assess the effects of increasing doses on rifapentine absorption and bioavailability and to evaluate the clearance changes over 14 days. A population analysis was performed with nonlinear mixed-effects modeling. Absorption, time-varying clearance, bioavailability, and empirical and semimechanistic autoinduction models were investigated. A one-compartment model linked to a transit compartment absorption model best described the data. The bioavailability of rifapentine decreased linearly by 2.5% for each 100-mg increase in dose. The autoinduction model suggested a dose-independent linear increase in clearance of the parent drug and metabolite over time from 1.2 and 3.1 liters.h(-1), respectively, after a single dose to 2.2 and 5.0 liters.h(-1), respectively, after 14 once-daily doses, with no plateau being reached by day 14. In clinical trial simulations using the final model, rifapentine demonstrated less-than-dose-proportional pharmacokinetics, but there was no plateau in exposures over the dose range tested (450 to 1,800 mg), and divided dosing increased exposures significantly. Thus, the proposed compartmental model incorporating daily dosing of rifapentine over a wide range of doses and time-related changes in bioavailability and clearance provides a useful tool for estimation of drug exposure that can be used to optimize rifapentine dosing for TB treatment. C1 [Savic, Radojka M.] UCSF, Sch Pharm Bioengn & Therapeut Sci, San Francisco, CA 94143 USA. [Lu, Yanhui; Nuermberger, Eric; Dorman, Susan E.; Dooley, Kelly E.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Bliven-Sizemore, Erin] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA USA. [Weiner, Marc] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Weiner, Marc] VAMC, San Antonio, TX USA. [Burman, William] Denver Publ Hlth, Denver, CO USA. RP Savic, RM (reprint author), UCSF, Sch Pharm Bioengn & Therapeut Sci, San Francisco, CA 94143 USA. EM Rada.Savic@ucsf.edu FU Tuberculosis Trials Consortium (TBTC) of the Centers for Disease Control and Prevention (CDC); UCSF-CTSI [KL2 TR000143-07]; [K23AI080842] FX We acknowledge the Tuberculosis Trials Consortium (TBTC) of the Centers for Disease Control and Prevention (CDC) for its support of this secondary analysis of TBTC study 29B data. Support was also provided by K23AI080842 (to K. E. D.) and UCSF-CTSI grant number KL2 TR000143-07 (to R.M.S.). NR 29 TC 6 Z9 6 U1 0 U2 8 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JUN PY 2014 VL 58 IS 6 BP 3035 EP 3042 DI 10.1128/AAC.01918-13 PG 8 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA AK9VP UT WOS:000338776900006 PM 24614383 ER PT J AU Flint, M McMullan, LK Dodd, KA Bird, BH Khristova, ML Nichol, ST Spiropoulou, CF AF Flint, Mike McMullan, Laura K. Dodd, Kimberly A. Bird, Brian H. Khristova, Marina L. Nichol, Stuart T. Spiropoulou, Christina F. TI Inhibitors of the Tick-Borne, Hemorrhagic Fever-Associated Flaviviruses SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID HEPATITIS-C VIRUS; WEST-NILE-VIRUS; KYASANUR-FOREST-DISEASE; ANTIVIRAL COMPOUNDS; RNA-POLYMERASE; PROTEASE INHIBITORS; NUCLEOSIDE ANALOGS; REPLICON CELLS; DENGUE VIRUS; REPLICATION AB No antiviral therapies are available for the tick-borne flaviviruses associated with hemorrhagic fevers: Kyasanur Forest disease virus (KFDV), both classical and the Alkhurma hemorrhagic fever virus (AHFV) subtype, and Omsk hemorrhagic fever virus (OHFV). We tested compounds reported to have antiviral activity against members of the Flaviviridae family for their ability to inhibit AHFV replication. 6-Azauridine (6-azaU), 2'-C-methylcytidine (2'-CMC), and interferon alpha 2a (IFN-alpha 2a) inhibited the replication of AHFV and also KFDV, OHFV, and Powassan virus. The combination of IFN-alpha 2a and 2'-CMC exerted an additive antiviral effect on AHFV, and the combination of IFN-alpha 2a and 6-azaU was moderately synergistic. The combination of 2'-CMC and 6-azaU was complex, being strongly synergistic but with a moderate level of antagonism. The antiviral activity of 6-azaU was reduced by the addition of cytidine but not guanosine, suggesting that it acted by inhibiting pyrimidine biosynthesis. To investigate the mechanism of action of 2'-CMC, AHFV variants with reduced susceptibility to 2'-CMC were selected. We used a replicon system to assess the substitutions present in the selected AHFV population. A double NS5 mutant, S603T/C666S, and a triple mutant, S603T/C666S/M644V, were more resistant to 2'-CMC than the wild-type replicon. The S603T/C666S mutant had a reduced level of replication which was increased when M644V was also present, although the replication of this triple mutant was still below that of the wild type. The S603 and C666 residues were predicted to lie in the active site of the AHFV NS5 polymerase, implicating the catalytic center of the enzyme as the binding site for 2'-CMC. C1 [Flint, Mike; McMullan, Laura K.; Dodd, Kimberly A.; Bird, Brian H.; Khristova, Marina L.; Nichol, Stuart T.; Spiropoulou, Christina F.] Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA 30333 USA. [Dodd, Kimberly A.] Univ Calif Davis, Sch Vet Med, Davis, CA 95616 USA. RP Spiropoulou, CF (reprint author), Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA 30333 USA. EM ccs8@cdc.gov OI Flint, Michael/0000-0002-5373-787X NR 48 TC 9 Z9 9 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JUN PY 2014 VL 58 IS 6 BP 3206 EP 3216 DI 10.1128/AAC.02393-14 PG 11 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA AK9VP UT WOS:000338776900028 PM 24663025 ER PT J AU Marinucci, GD Luber, G Uejio, CK Saha, S Hess, JJ AF Marinucci, Gino D. Luber, George Uejio, Christopher K. Saha, Shubhayu Hess, Jeremy J. TI Building Resilience against Climate Effects-A Novel Framework to Facilitate Climate Readiness in Public Health Agencies SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH LA English DT Article DE adaptation; climate change; public health agency; public health; resilience ID HEAT-RELATED MORTALITY; TIME-SERIES; DECISION-MAKING; CASE-CROSSOVER; UNITED-STATES; VULNERABILITY; ADAPTATION; LESSONS; RISKS; INTERVENTIONS AB Climate change is anticipated to have several adverse health impacts. Managing these risks to public health requires an iterative approach. As with many risk management strategies related to climate change, using modeling to project impacts, engaging a wide range of stakeholders, and regularly updating models and risk management plans with new information-hallmarks of adaptive management-are considered central tenets of effective public health adaptation. The Centers for Disease Control and Prevention has developed a framework, entitled Building Resilience Against Climate Effects, or BRACE, to facilitate this process for public health agencies. Its five steps are laid out here. Following the steps laid out in BRACE will enable an agency to use the best available science to project likely climate change health impacts in a given jurisdiction and prioritize interventions. Adopting BRACE will also reinforce public health's established commitment to evidence-based practice and institutional learning, both of which will be central to successfully engaging the significant new challenges that climate change presents. C1 [Marinucci, Gino D.; Luber, George; Uejio, Christopher K.; Saha, Shubhayu; Hess, Jeremy J.] Ctr Dis Control & Prevent, Climate & Hlth Program, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Uejio, Christopher K.] Florida State Univ, Dept Geog, Tallahassee, FL 32306 USA. [Hess, Jeremy J.] Emory Univ, Rollins Sch Publ Hlth, Dept Environm Hlth, Atlanta, GA 30322 USA. [Hess, Jeremy J.] Emory Univ, Sch Med, Dept Emergency Med, Atlanta, GA 30322 USA. RP Hess, JJ (reprint author), Ctr Dis Control & Prevent, Climate & Hlth Program, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. EM ipx1@cdc.gov; gcl4@cdc.gov; cuejio@fsu.edu; hsf5@cdc.gov; jhess@emory.edu NR 100 TC 9 Z9 9 U1 3 U2 13 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1660-4601 J9 INT J ENV RES PUB HE JI Int. J. Environ. Res. Public Health PD JUN PY 2014 VL 11 IS 6 BP 6433 EP 6458 DI 10.3390/ijerph110606433 PG 26 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AK8FL UT WOS:000338662600055 PM 24991665 ER PT J AU Dodd, KA McElroy, AK Jones, TL Zaki, SR Nichol, ST Spiropoulou, CF AF Dodd, Kimberly A. McElroy, Anita K. Jones, Tara L. Zaki, Sherif R. Nichol, Stuart T. Spiropoulou, Christina F. TI Rift Valley Fever Virus Encephalitis Is Associated with an Ineffective Systemic Immune Response and Activated T Cell Infiltration into the CNS in an Immunocompetent Mouse Model SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID CENTRAL-NERVOUS-SYSTEM; BLOOD-BRAIN-BARRIER; NSS PROTEIN; JAPANESE ENCEPHALITIS; INTRANASAL INFECTION; NEUROLOGIC DISEASE; MURINE MODEL; MICE; TRANSCRIPTION; CHALLENGE AB Background: Rift Valley fever virus (RVFV) causes outbreaks of severe disease in livestock and humans throughout Africa and the Arabian Peninsula. In people, RVFV generally causes a self-limiting febrile illness but in a subset of individuals, it progresses to more serious disease. One manifestation is a delayed-onset encephalitis that can be fatal or leave the afflicted with long-term neurologic sequelae. In order to design targeted interventions, the basic pathogenesis of RVFV encephalitis must be better understood. Methodology/Principal Findings: To characterize the host immune responses and viral kinetics associated with fatal and nonfatal infections, mice were infected with an attenuated RVFV lacking NSs (Delta NSs) that causes lethal disease only when administered intranasally (IN). Following IN infection, C57BL/6 mice developed severe neurologic disease and succumbed 7-9 days post-infection. In contrast, inoculation of Delta NSs virus subcutaneously in the footpad (FP) resulted in a subclinical infection characterized by a robust immune response with rapid antibody production and strong T cell responses. IN-inoculated mice had delayed antibody responses and failed to clear virus from the periphery. Severe neurological signs and obtundation characterized end stage-disease in IN-inoculated mice, and within the CNS, the development of peak virus RNA loads coincided with strong proinflammatory responses and infiltration of activated T cells. Interestingly, depletion of T cells did not significantly alter survival, suggesting that neurologic disease is not a by-product of an aberrant immune response. Conclusions/Significance: Comparison of fatal (IN-inoculated) and nonfatal (FP-inoculated) DNSs RVFV infections in the mouse model highlighted the role of the host immune response in controlling viral replication and therefore determining clinical outcome. There was no evidence to suggest that neurologic disease is immune-mediated in RVFV infection. These results provide important insights for the future design of vaccines and therapeutic options. C1 [Dodd, Kimberly A.; McElroy, Anita K.; Nichol, Stuart T.; Spiropoulou, Christina F.] Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA 30333 USA. [Dodd, Kimberly A.] Univ Calif Davis, Sch Vet Med, Davis, CA 95616 USA. [McElroy, Anita K.] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA. [Jones, Tara L.; Zaki, Sherif R.] Ctr Dis Control & Prevent, Infect Dis Pathol Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA USA. RP Dodd, KA (reprint author), Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA 30333 USA. EM ccs8@cdc.gov FU Pediatric Infectious Disease Society-St. Jude Fellowship award; Atlanta Pediatric Scholars Program; NIH FX AKM is supported by the Pediatric Infectious Disease Society-St. Jude Fellowship award and the Atlanta Pediatric Scholars Program, and is also the recipient of an NIH loan repayment award. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 48 TC 10 Z9 10 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD JUN PY 2014 VL 8 IS 6 AR e2874 DI 10.1371/journal.pntd.0002874 PG 13 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AL0VW UT WOS:000338846100017 PM 24922480 ER PT J AU Ahn, KW Kosoy, M Chan, KS AF Ahn, Kwang Woo Kosoy, Michael Chan, Kung-Sik TI An approach for modeling cross-immunity of two strains, with application to variants of Bartonella in terms of genetic similarity SO EPIDEMICS LA English DT Article DE Bartonella; Conditional least squares; Cross-immunity; SIR model ID CITRATE SYNTHASE GENE; INFLUENZA; POPULATION; DYNAMICS; RODENTS AB We developed a two-strain susceptible-infected-recovered (SIR) model that provides a framework for inferring the cross-immunity between two strains of a bacterial species in the host population with discretely sampled co-infection time-series data. Moreover, the model accounts for seasonality in host reproduction. We illustrate an approach using a dataset describing co-infections by several strains of bacteria circulating within a population of cotton rats (Sigmodon hispidus). Bartonella strains were clustered into three genetically close groups, between which the divergence is correspondent to the accepted level of separate bacterial species. The proposed approach revealed no cross-immunity between genetic clusters while limited cross-immunity might exist between subgroups within the clusters. (C) 2014 Published by Elsevier B.V. C1 [Ahn, Kwang Woo] Med Coll Wisconsin, Div Biostat, Milwaukee, WI 53226 USA. [Kosoy, Michael] Ctr Dis Control & Prevent, Ft Collins, CO USA. [Chan, Kung-Sik] Univ Iowa, Dept Stat & Actuarial Sci, Iowa City, IA 52242 USA. RP Ahn, KW (reprint author), Med Coll Wisconsin, Div Biostat, Milwaukee, WI 53226 USA. EM kwooahn@mcw.edu; mck3@cdc.gov; kung-sik-chan@uiowa.edu FU U.S. National Science Foundation [DMS-1021896] FX This work was partially supported by the U.S. National Science Foundation (DMS-1021896). The authors would like to thank Dr. Jennifer Le-Rademacher and two anonymous reviewers for their helpful comments and suggestions, which significantly improved the manuscript and Mr. Franco Mendolia for his computational assistance. NR 23 TC 0 Z9 0 U1 1 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1755-4365 J9 EPIDEMICS-NETH JI Epidemics PD JUN PY 2014 VL 7 BP 7 EP 12 DI 10.1016/j.epidem.2014.03.001 PG 6 WC Infectious Diseases SC Infectious Diseases GA AK8UU UT WOS:000338704900002 PM 24928664 ER PT J AU Spears, DR McNeil, C Warnock, E Trapp, J Oyinloye, O Whitehurst, V Decker, KC Chapman, S Campbell, M Meechan, P AF Spears, D. Ross McNeil, Carrie Warnock, Eli Trapp, Jonathan Oyinloye, Oluremi Whitehurst, Vanessa Decker, K. C. Chapman, Sandy Campbell, Morris Meechan, Paul TI Predicting Temporal Trends in Total Absenteeism Rates for Civil Service Employees of a Federal Public Health Agency SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID SICKNESS ABSENCE; LEAVE AB Objective: This study evaluates the predictability in temporal absences trends due to all causes (total absenteeism) among employees at a federal agency. The objective is to determine how leave trends vary within the year, and determine whether trends are predictable. Methods: Ten years of absenteeism data from an attendance system were analyzed for rates of total absence. Results: Trends over a 10-year period followed predictable and regular patterns during a given year that correspond to major holiday periods. Temporal trends in leave among small, medium, and large facilities compared favorably with the agency as a whole. Conclusions: Temporal trends in total absenteeism rates for an organization can be determined using its attendance system. The ability to predict employee absenteeism rates can be extremely helpful for management in optimizing business performance and ensuring that an organization meets its mission. C1 [Spears, D. Ross; McNeil, Carrie; Warnock, Eli; Meechan, Paul] Ctr Dis Control & Prevent, Environm Safety & Hlth Compliance Off, Atlanta, GA 30333 USA. [Trapp, Jonathan] Ctr Dis Control & Prevent, Off Safety Secur & Asset Management, Atlanta, GA 30333 USA. [Oyinloye, Oluremi; Whitehurst, Vanessa; Decker, K. C.] Booz Allen & Hamilton Inc, Mclean, VA 22102 USA. [Chapman, Sandy] Ctr Dis Control & Prevent, Program Grants Off, Atlanta, GA 30333 USA. [Campbell, Morris] Ctr Dis Control & Prevent, Management Syst Informat Off, Atlanta, GA 30333 USA. RP Spears, DR (reprint author), Ctr Dis Control & Prevent, US Publ Hlth Serv, 1600 Clifton Rd NE,MS F-05, Atlanta, GA 30333 USA. EM ava3@cdc.gov FU Centers for Disease Control and Prevention, Atlanta, Georgia FX Source of funding is the Centers for Disease Control and Prevention, Atlanta, Georgia. NR 21 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 EI 1536-5948 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD JUN PY 2014 VL 56 IS 6 BP 632 EP 638 DI 10.1097/JOM.0000000000000155 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AK9PX UT WOS:000338760100011 PM 24854256 ER PT J AU Greer, S Kramer, MR Cook-Smith, JN Casper, ML AF Greer, Sophia Kramer, Michael R. Cook-Smith, Jessica N. Casper, Michele L. TI Metropolitan Racial Residential Segregation and Cardiovascular Mortality: Exploring Pathways SO JOURNAL OF URBAN HEALTH-BULLETIN OF THE NEW YORK ACADEMY OF MEDICINE LA English DT Article DE Residential segregation; Racial segregation; Metropolitan; Heart disease; Stroke; Cardiovascular disease; Social context; Economic context ID SOCIAL-DISORGANIZATION THEORY; STROKE MORTALITY; DISPARITIES; HEALTH; DIRECTIONS; DISEASE; BLACKS; WHITES; POLICY; CARE AB Racial residential segregation has been associated with an increased risk for heart disease and stroke deaths. However, there has been little research into the role that candidate mediating pathways may play in the relationship between segregation and heart disease or stroke deaths. In this study, we examined the relationship between metropolitan statistical area (MSA)-level segregation and heart disease and stroke mortality rates, by age and race, and also estimated the effects of various educational, economic, social, and health-care indicators (which we refer to as pathways) on this relationship. We used Poisson mixed models to assess the relationship between the isolation index in 265 U.S. MSAs and county-level (heart disease, stroke) mortality rates. All models were stratified by race (non-Hispanic black, non-Hispanic white), age group (35-64 years, a parts per thousand yen65 years), and cause of death (heart disease, stroke). We included each potential pathway in the model separately to evaluate its effect on the segregation-mortality association. Among blacks, segregation was positively associated with heart disease mortality rates in both age groups but only with stroke mortality rates in the older age group. Among whites, segregation was marginally associated with heart disease mortality rates in the younger age group and was positively associated with heart disease mortality rates in the older age group. Three of the potential pathways we explored attenuated relationships between segregation and mortality rates among both blacks and whites: percentage of female-headed households, percentage of residents living in poverty, and median household income. Because the percentage of female-headed households can be seen as a proxy for the extent of social disorganization, our finding that it has the greatest attenuating effect on the relationship between racial segregation and heart disease and stroke mortality rates suggests that social disorganization may play a strong role in the elevated rates of heart disease and stroke found in racially segregated metropolitan areas. C1 [Greer, Sophia; Casper, Michele L.] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA 30341 USA. [Kramer, Michael R.; Cook-Smith, Jessica N.] Emory Univ, Atlanta, GA 30322 USA. RP Greer, S (reprint author), Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, 4770 Buford Hwy NE,MS F-72, Atlanta, GA 30341 USA. EM sgreer@cdc.gov FU Research Participation Program at CDC FX Dr. Kramer was supported in part by the Research Participation Program at CDC administered by the Oak Ridge Institute of Science and Education. NR 31 TC 1 Z9 1 U1 3 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1099-3460 EI 1468-2869 J9 J URBAN HEALTH JI J. Urban Health PD JUN PY 2014 VL 91 IS 3 BP 499 EP 509 DI 10.1007/s11524-013-9834-7 PG 11 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA AK8HI UT WOS:000338667900008 PM 24154933 ER PT J AU Shurin, MR Yanamala, N Kisin, ER Tkach, AV Shurin, GV Murray, AR Leonard, HD Reynolds, JS Gutkin, DW Star, A Fadeel, B Savolainen, K Kagan, VE Shvedova, AA AF Shurin, Michael R. Yanamala, Naveena Kisin, Elena R. Tkach, Alexey V. Shurin, Galina V. Murray, Ashley R. Leonard, Howard D. Reynolds, Jeffrey S. Gutkin, Dmirtiy W. Star, Alexander Fadeel, Bengt Savolainen, Kai Kagan, Valerian E. Shvedova, Anna A. TI Graphene Oxide Attenuates Th2-Type Immune Responses, but Augments Airway Remodeling and Hyperresponsiveness in a Murine Model of Asthma SO ACS NANO LA English DT Article DE Th2 responses; macrophage activation; IgE-independent AHR; chitinases ID CHITINASE-LIKE PROTEIN; ACIDIC MAMMALIAN CHITINASE; MULTIWALLED CARBON NANOTUBES; INDUCED TOXICITY FOCUS; EPITHELIAL-CELLS; DIFFERENTIAL EXPRESSION; ACTIVATED MACROPHAGES; SIGNALING PATHWAYS; PRISTINE GRAPHENE; BRONCHIAL-ASTHMA AB Several lines of evidence indicate that exposure to nanoparticles (NPs) is able to modify airway immune responses, thus facilitating the development of respiratory diseases. Graphene oxide (GO) is a promising carbonaceous nanomaterial with unique physicochemical properties, envisioned for a multitude of medical and industrial applications. In this paper, we determined how exposure to GO modulates the allergic pulmonary response. Using a murine model of ovalbumin (OVA)-induced asthma, we revealed that GO, given at the sensitization stage, augmented airway hyperresponsiveness and airway remodeling in the form of goblet cell hyperplasia and smooth muscle hypertrophy. At the same time, the levels of the cytokines IL-4, IL-5, and IL-13 were reduced in broncho-alveolar lavage (BAL) fluid in GO-exposed mice. Exposure to GO during sensitization with OVA decreased eosinophil accumulation and increased recruitment of macrophages in BAL fluid. In line with the cytokine profiles, sensitization with OVA in the presence of GO stimulated the production of OVA-specific IgG2a and down-regulated the levels of IgE and IgG1. Moreover, exposure to GO increased the macrophage production of the mammalian chitinases, CHI3L1 and AMCase, whose expression is associated with asthma. Finally, molecular modeling has suggested that GO may directly interact with chitinase, affecting AMCase activity, which has been directly proven in our studies. Thus, these data show that GO exposure attenuates Th2 immune response in a model of OVA-induced asthma, but leads to potentiation of airway remodeling and hyperresponsiveness, with the induction of mammalian chitinases. C1 [Shurin, Michael R.; Shurin, Galina V.; Gutkin, Dmirtiy W.] Univ Pittsburgh, Dept Pathol, Sch Med, Pittsburgh, PA 15260 USA. [Yanamala, Naveena; Kisin, Elena R.; Tkach, Alexey V.; Murray, Ashley R.; Leonard, Howard D.; Reynolds, Jeffrey S.; Shvedova, Anna A.] NIOSH, Pathol & Physiol Res Branch, CDC, Morgantown, WV 26505 USA. [Star, Alexander] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA. [Kagan, Valerian E.] Univ Pittsburgh, Dept Environm & Occupat Hlth, Pittsburgh, PA 15260 USA. [Fadeel, Bengt] Karolinska Inst, Inst Environm Med, Div Mol Toxicol, S-17177 Stockholm, Sweden. [Savolainen, Kai] Finnish Inst Occupat Hlth, Nanosafety Res Ctr, Helsinki 02500, Finland. [Shvedova, Anna A.] W Virginia Univ, Dept Physiol & Pharmacol, Morgantown, WV 26505 USA. RP Shvedova, AA (reprint author), NIOSH, Pathol & Physiol Res Branch, CDC, Morgantown, WV 26505 USA. EM ats1@cdc.gov FU NIOSH [OH008282]; NORA [0HELD015]; EC-FP-7-NANOSOLUTIONS; NIEHS [R01ES019304] FX This work was supported by NIOSH OH008282, NORA 0HELD015, EC-FP-7-NANOSOLUTIONS, and NIEHS R01ES019304. The authors are grateful to M. Farcas, M. Hatfield, S. Stanley, A. Cumpston, J. Cumpston, and D. Schwegler-Berry for the technical assistance. NR 68 TC 11 Z9 12 U1 6 U2 29 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1936-0851 EI 1936-086X J9 ACS NANO JI ACS Nano PD JUN PY 2014 VL 8 IS 6 BP 5585 EP 5599 DI 10.1021/nn406454u PG 15 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA AK0FV UT WOS:000338089200023 PM 24847914 ER PT J AU Yadav, K Mathur, G Ford, B Miller, R AF Yadav, K. Mathur, G. Ford, B. Miller, R. CA CDC Working Grp TI A Case Cluster of Lymphocytic Choriomeningitis Virus Transmitted Via Organ Transplantation SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Meeting Abstract CT World Transplant Congress CY JUL 26-31, 2014 CL San Francisco, CA C1 [Yadav, K.; Mathur, G.; Ford, B.; Miller, R.] Univ Iowa, Carver Coll Med, Iowa City, IA USA. [CDC Working Grp] Ctr Dis Control, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1600-6135 EI 1600-6143 J9 AM J TRANSPLANT JI Am. J. Transplant. PD JUN PY 2014 VL 14 SU 3 MA D2381 BP 768 EP 768 PG 1 WC Surgery; Transplantation SC Surgery; Transplantation GA AJ9LU UT WOS:000338033303389 ER PT J AU Guy, GP Yabroff, KR Ekwueme, DU Smith, AW Dowling, EC Rechis, R Nutt, S Richardson, LC AF Guy, Gery P., Jr. Yabroff, K. Robin Ekwueme, Donatus U. Smith, Ashley Wilder Dowling, Emily C. Rechis, Ruth Nutt, Stephanie Richardson, Lisa C. TI Estimating The Health And Economic Burden Of Cancer Among Those Diagnosed As Adolescents And Young Adults SO HEALTH AFFAIRS LA English DT Article ID UNITED-STATES; SURVIVORS; PRODUCTIVITY; PREVALENCE; IMPACT; CHALLENGES; COSTS; CARE AB Adolescent and young adult cancer survivors-those who were ages 15-39 at their first cancer diagnosis-have important health limitations. These survivors are at risk for higher health care expenditures and lost productivity, compared to adults without a history of cancer. Using Medical Expenditure Panel Survey data, we present nationally representative estimates of the economic burden among people who were diagnosed with cancer in adolescence or young adulthood. Our findings demonstrate that surviving cancer at this age is associated with a substantial economic burden. Compared to adults without a history of cancer, adolescent and young adult cancer survivors had excess annual medical expenditures of $3,170 per person and excess annual productivity losses of $2,250 per person. Multifaceted prevention strategies, including education and sustained intervention programs to ensure access to lifelong risk-based follow-up care, may be effective ways to improve the economic outcomes associated with cancer survivorship in this population. C1 [Guy, Gery P., Jr.] Ctr Dis Control & Prevent CDC, Div Canc Prevent & Control, Atlanta, GA 30333 USA. [Yabroff, K. Robin; Smith, Ashley Wilder] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. [Ekwueme, Donatus U.] CDC, Div Canc Prevent & Control, Atlanta, GA 30333 USA. [Dowling, Emily C.] Massachusetts Gen Hosp, Inst Technol Assessment, Boston, MA 02114 USA. [Rechis, Ruth] LIVESTRONG Fdn, Austin, TX USA. [Nutt, Stephanie] LIVESTRONG Fdn, Res & Evaluat Team, Austin, TX USA. [Richardson, Lisa C.] CDC, Div Blood Disorders, Atlanta, GA 30333 USA. RP Guy, GP (reprint author), Ctr Dis Control & Prevent CDC, Div Canc Prevent & Control, Atlanta, GA 30333 USA. EM irm2@cdc.gov FU Intramural CDC HHS [CC999999] NR 31 TC 17 Z9 18 U1 7 U2 14 PU PROJECT HOPE PI BETHESDA PA 7500 OLD GEORGETOWN RD, STE 600, BETHESDA, MD 20814-6133 USA SN 0278-2715 J9 HEALTH AFFAIR JI Health Aff. PD JUN PY 2014 VL 33 IS 6 BP 1024 EP 1031 DI 10.1377/hlthaff.2013.1425 PG 8 WC Health Care Sciences & Services; Health Policy & Services SC Health Care Sciences & Services GA AK1PL UT WOS:000338187200014 PM 24889952 ER PT J AU Scott, RD Sinkowitz-Cochran, R Wise, ME Baggs, J Goates, S Solomon, SL McDonald, LC Jernigan, JA AF Scott, R. Douglas, II Sinkowitz-Cochran, Ronda Wise, Matthew E. Baggs, James Goates, Scott Solomon, Steven L. McDonald, L. Clifford Jernigan, John A. TI CDC Central-Line Bloodstream Infection Prevention Efforts Produced Net Benefits Of At Least $640 Million During 1990-2008 SO HEALTH AFFAIRS LA English DT Article ID CARE-ASSOCIATED INFECTIONS; UNITED-STATES; GUIDELINES AB The prevention of central line-associated bloodstream infections in patients in hospital critical care units has been a target of efforts by the Centers for Disease Control and Prevention (CDC) since the 1960s. We developed a historical economic model to measure the net economic benefits of preventing these infections in Medicare and Medicaid patients in critical care units for the period 1990-2008-a time when reductions attributable to federal investment resulted primarily from CDC efforts-using the cost perspective of the federal government as a third-party payer. The estimated net economic benefits ranged from $640 million to $1.8 billion, with the corresponding net benefits per case averted ranging from $15,780 to $24,391. The per dollar rate of return on the CDC's investments ranged from $3.88 to $23.85. These findings suggest that investments in CDC programs targeting other health care-associated infections also have the potential to produce savings by lowering Medicare and Medicaid reimbursements. C1 [Scott, R. Douglas, II] Ctr Dis Control & Prevent CDC, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. [Sinkowitz-Cochran, Ronda; Baggs, James; McDonald, L. Clifford] CDC, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. [Wise, Matthew E.] CDC, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA. [Goates, Scott] CDC, Atlanta, GA 30333 USA. [Solomon, Steven L.] CDC, Div Healthcare Qual Promot, Off Antimicrobial Resistance, Atlanta, GA 30333 USA. [Jernigan, John A.] CDC, Div Healthcare Qual Promot, Off Prevent Res & Evaluat, Atlanta, GA 30333 USA. RP Scott, RD (reprint author), Ctr Dis Control & Prevent CDC, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. EM DScott1@cdc.gov OI Baggs, James/0000-0003-0757-4683 NR 28 TC 5 Z9 6 U1 1 U2 3 PU PROJECT HOPE PI BETHESDA PA 7500 OLD GEORGETOWN RD, STE 600, BETHESDA, MD 20814-6133 USA SN 0278-2715 J9 HEALTH AFFAIR JI Health Aff. PD JUN PY 2014 VL 33 IS 6 BP 1040 EP 1047 DI 10.1377/hlthaff.2013.0865 PG 8 WC Health Care Sciences & Services; Health Policy & Services SC Health Care Sciences & Services GA AK1PL UT WOS:000338187200016 PM 24889954 ER PT J AU Shapiro-Mendoza, CK AF Shapiro-Mendoza, Carrie K. TI Commentary: Mediation and moderation analyses: a novel approach to exploring the complex pathways between maternal medical conditions, preterm birth and associated newborn morbidity risk SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Editorial Material C1 Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30333 USA. RP Shapiro-Mendoza, CK (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, MS F74,4770 Buford Highway,NE, Atlanta, GA 30333 USA. EM ayn9@cdc.gov FU Intramural CDC HHS [CC999999] NR 10 TC 1 Z9 1 U1 0 U2 4 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0300-5771 EI 1464-3685 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PD JUN PY 2014 VL 43 IS 3 BP 815 EP 817 DI 10.1093/ije/dyt285 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AK0SZ UT WOS:000338127000022 PM 24464191 ER PT J AU Buchanan, ND Block, R Smith, AW Tai, E AF Buchanan, Natasha D. Block, Rebecca Smith, Ashley Wilder Tai, Eric TI Psychosocial Barriers and Facilitators to Clinical Trial Enrollment and Adherence for Adolescents With Cancer SO PEDIATRICS LA English DT Article DE adherence; adolescent; cancer survivors; clinical trial; enrollment; psychosocial ID EDUCATION SHARE PROGRAM; YOUNG-ADULT CANCER; CHILDHOOD-CANCER; LYMPHOBLASTIC-LEUKEMIA; SURVIVOR HEALTH; CONSENT FORMS; PARTICIPATION; CHILDREN; ISSUES; EXPERIENCES AB Adolescents (aged 15-19 years) have not experienced the same survival gains as children and older adults diagnosed with cancer. Poor clinical trial enrollment and adherence rates among adolescents may account for some of this disparity. Although biological, regulatory, systemic, and practice-related challenges to clinical trial enrollment and adherence have been examined, studies of psychosocial factors, which can serve as barriers or facilitators to enrollment and adherence, are limited. To bring attention to these psychological factors, we reviewed existing literature on psychosocial barriers and facilitators that can affect an adolescent's decision to enroll and adhere to a clinical trial. We also provide potential strategies to address psychosocial factors affecting clinical trial accrual and adherence. C1 [Buchanan, Natasha D.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Epidemiol & Appl Res Branch, Atlanta, GA 30341 USA. [Tai, Eric] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Comprehens Canc Control Branch, Atlanta, GA 30341 USA. [Block, Rebecca] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Smith, Ashley Wilder] NCI, Outcomes Res Branch, Bethesda, MD 20892 USA. RP Buchanan, ND (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway NE,MS K-55, Atlanta, GA 30341 USA. EM nbuchanan@cdc.gov NR 64 TC 3 Z9 3 U1 1 U2 4 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD JUN PY 2014 VL 133 SU 3 BP S123 EP S130 DI 10.1542/peds.2014-01221 PG 8 WC Pediatrics SC Pediatrics GA AK3TG UT WOS:000338347000008 PM 24918211 ER PT J AU Tai, E Buchanan, N Eliman, D Westervelt, L Beaupin, L Lawvere, S Bleyer, A AF Tai, Eric Buchanan, Natasha Eliman, Dena Westervelt, Lauren Beaupin, Lynda Lawvere, Silvana Bleyer, Archie TI Understanding and Addressing the Lack of Clinical Trial Enrollment Among Adolescents With Cancer SO PEDIATRICS LA English DT Article DE adolescents; cancer; clinical trial enrollment; oncology; teens; youth ID ACUTE LYMPHOBLASTIC-LEUKEMIA; YOUNG-ADULT CANCER; SURVIVORS; CARE; ONCOLOGY; PARTICIPATION; SURVEILLANCE; CHALLENGES; CHILDHOOD; PROTOCOLS AB Despite overall improvement in survival, morbidity, and quality of life of US patients with cancer, this progress is less prevalent in the population of adolescent and young adult patients with cancer, including those between the ages of 15 and 19 years. Evidence suggests that participation in clinical trials is associated with better survival outcomes among children and adolescents with cancer; however, adolescents have lower clinical trial participation rates compared with younger age cohorts. To better understand the unique concerns among adolescent patients with cancer, the Division of Cancer Prevention and Control at the Centers for Disease Control and Prevention convened a workgroup of researchers and health care providers in the field of adolescent and young adult oncology and cancer survivorship to examine the barriers and challenges limiting the participation of adolescents in clinical trials and to define ways to improve upon these concerns. This article summarizes the activities of the workgroup and their suggestions for enhanced accrual. C1 [Tai, Eric; Buchanan, Natasha] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Eliman, Dena; Westervelt, Lauren] SciMetrika LLC, Res Triangle Pk, NC USA. [Beaupin, Lynda] Roswell Pk Canc Inst, Buffalo, NY 14263 USA. [Lawvere, Silvana] Univ N Carolina, Sch Publ Hlth, Dept Biostat, Chapel Hill, NC USA. [Bleyer, Archie] St Charles Hlth Syst, Qual Dept, Bend, OR USA. RP Tai, E (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, 4770 Buford Hwy,MS-F76, Atlanta, GA 30341 USA. EM etai@cdc.gov NR 36 TC 7 Z9 7 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD JUN PY 2014 VL 133 SU 3 BP S98 EP S103 DI 10.1542/peds.2014-0122D PG 6 WC Pediatrics SC Pediatrics GA AK3TG UT WOS:000338347000003 PM 24918214 ER PT J AU Tai, E Buchanan, N Westervelt, L Elimam, D Lawvere, S AF Tai, Eric Buchanan, Natasha Westervelt, Lauren Elimam, Dena Lawvere, Silvana TI Treatment Setting, Clinical Trial Enrollment, and Subsequent Outcomes Among Adolescents With Cancer: A Literature Review SO PEDIATRICS LA English DT Review DE clinical trial enrollment; cancer; adolescents; oncology ID ACUTE LYMPHOBLASTIC-LEUKEMIA; YOUNG-ADULT SURVIVORS; AYA ONCOLOGY PATIENTS; CHILDHOOD-CANCER; OLDER ADOLESCENTS; CHILDREN; AGE; PROGRAM; CARE; PROTOCOLS AB BACKGROUND: There has been an overall improvement in survival rates for persons with cancer over the past 35 years. However, these gains are less prevalent among adolescents with cancer aged 15 to 19 years, which may be due to lower clinical trial enrollment among adolescents with cancer. METHODS: We conducted a literature review to assess current research regarding clinical trial enrollment and subsequent outcomes among adolescents with cancer. The search included English-language publications that reported original data from January 1985 to October 2011. RESULTS: The search identified 539 records. Of these 539 records, there were 30 relevant original research articles. Multiple studies reported that adolescents with cancer are enrolled in clinical trials at lower rates compared with younger children and older adults. Treatment setting, physician type, and institution type may all be factors in the low enrollment rate among adolescents. Few data focused solely on adolescents, with many studies combining adolescents with young adults. The number of available studies related to this topic was limited, with significant variability in study design, methods, and outcomes. CONCLUSIONS: This literature review suggests that adolescents with cancer are not treated at optimal settings and are enrolled in clinical trials at low rates. This may lead to inferior treatment and poor subsequent medical and psychosocial outcomes. The scarcity in data further validates the need for additional research focusing on this population. C1 [Tai, Eric; Buchanan, Natasha] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Westervelt, Lauren; Elimam, Dena] SciMetrika LLC, Res Triangle Pk, NC USA. [Lawvere, Silvana] Univ N Carolina, Sch Publ Hlth, Dept Biostat, Chapel Hill, NC USA. RP Tai, E (reprint author), Ctr Dis Control & Prevent, Div Canc Control & Prevent, 4770 Buford Hwy,MS-F76, Atlanta, GA 30341 USA. EM etai@cdc.gov NR 49 TC 4 Z9 4 U1 1 U2 2 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD JUN PY 2014 VL 133 SU 3 BP S91 EP S97 DI 10.1542/peds.2014-0122C PG 7 WC Pediatrics SC Pediatrics GA AK3TG UT WOS:000338347000002 PM 24918213 ER PT J AU Tai, E Beaupin, L Bleyer, A AF Tai, Eric Beaupin, Lynda Bleyer, Archie TI Clinical Trial Enrollment Among Adolescents With Cancer: Supplement Overview SO PEDIATRICS LA English DT Article DE clinical trial; enrollment; adolescent ID YOUNG-ADULT SURVIVORS; CHILDHOOD-CANCER; OLDER ADOLESCENTS; AYA ONCOLOGY; DIAGNOSIS; PATTERNS; OUTCOMES; PROGRAM; CARE; SITE AB BACKGROUND: Survival rates for children with cancer have significantly increased over the past 35 years. However, adolescents with cancer aged 15 to 19 years have had less progress in survival prolongation compared with younger children, which may be due to lower clinical trial enrollment among adolescents with cancer. To help address this issue, the Centers for Disease Control and Prevention (CDC) convened a series of webinars to identify salient issues and measures to address this problem. This supplement is intended to raise awareness about the unique challenges of clinical trial enrollment among adolescents with cancer. METHODS: The CDC convened a workgroup of researchers and health care providers in the field of adolescent and young adult oncology and cancer survivorship to examine the barriers and challenges limiting the participation of adolescents in clinical trials and to define ways to improve on these concerns. RESULTS: The workgroup identified 3 distinct issues affecting clinical trial enrollment among adolescents with cancer: (1) many adolescents with cancer are not referred to institutions where clinical trials are offered, (2) there are limited numbers of clinical trials for adolescents with cancer, and (3) psychosocial barriers impede adolescents with cancer from enrolling in clinical trials. CONCLUSIONS: Adolescents with cancer have the smallest proportion and least number of patients enrolled in clinical trials in pediatric oncology. Successfully addressing this challenge requires improving referral to existing clinical trials, addressing regulatory barriers to clinical trial enrollment, increasing the number of clinical trials for adolescents, and addressing unique psychosocial barriers to clinical trial enrollment. C1 [Tai, Eric] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Beaupin, Lynda] Roswell Pk Canc Inst, Buffalo, NY 14263 USA. [Bleyer, Archie] St Charles Hlth Syst, Qual Dept, Bend, OR USA. RP Tai, E (reprint author), Ctr Dis Control & Prevent, Div Canc Control & Prevent, 4770 Buford Hwy,MS-F76, Atlanta, GA 30341 USA. EM etai@cdc.gov NR 26 TC 5 Z9 5 U1 1 U2 1 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD JUN PY 2014 VL 133 SU 3 BP S85 EP S90 DI 10.1542/peds.2014-0122B PG 6 WC Pediatrics SC Pediatrics GA AK3TG UT WOS:000338347000001 PM 24918212 ER PT J AU Magadan, JG Altman, MO Ince, WL Hickman, HD Stevens, J Chevalier, A Baker, D Wilson, PC Ahmed, R Bennink, JR Yewdell, JW AF Magadan, Javier G. Altman, Meghan O. Ince, William L. Hickman, Heather D. Stevens, James Chevalier, Aaron Baker, David Wilson, Patrick C. Ahmed, Rafi Bennink, Jack R. Yewdell, Jonathan W. TI Biogenesis of Influenza A Virus Hemagglutinin Cross-Protective Stem Epitopes SO PLOS PATHOGENS LA English DT Article ID STALK-SPECIFIC ANTIBODIES; MEMORY B-CELLS; MONOCLONAL-ANTIBODIES; INTRACELLULAR-TRANSPORT; RECEPTOR-BINDING; IMMUNE-RESPONSE; GLYCOPROTEIN; NEUTRALIZATION; VACCINATION; TRIMERIZATION AB Antigenic variation in the globular domain of influenza A virus (IAV) hemagglutinin (HA) precludes effective immunity to this major human pathogen. Although the HA stem is highly conserved between influenza virus strains, HA stem-reactive antibodies (StRAbs) were long considered biologically inert. It is now clear, however, that StRAbs reduce viral replication in animal models and protect against pathogenicity and death, supporting the potential of HA stem-based immunogens as drift-resistant vaccines. Optimally designing StRAb-inducing immunogens and understanding StRAb effector functions require thorough comprehension of HA stem structure and antigenicity. Here, we study the biogenesis of HA stem epitopes recognized in cells infected with various drifted IAV H1N1 strains using mouse and human StRAbs. Using a novel immunofluorescence (IF)-based assay, we find that human StRAbs bind monomeric HA in the endoplasmic reticulum (ER) and trimerized HA in the Golgi complex (GC) with similar high avidity, potentially good news for producing effective monomeric HA stem immunogens. Though HA stem epitopes are nestled among several N-linked oligosaccharides, glycosylation is not required for full antigenicity. Rather, as N-linked glycans increase in size during intracellular transport of HA through the GC, StRAb binding becomes temperature-sensitive, binding poorly to HA at 4 degrees C and well at 37 degrees C. A de novo designed, 65-residue protein binds the mature HA stem independently of temperature, consistent with a lack of N-linked oligosaccharide steric hindrance due to its small size. Likewise, StRAbs bind recombinant HA carrying simple N-linked glycans in a temperature-independent manner. Chemical cross-linking experiments show that N-linked oligosaccharides likely influence StRAb binding by direct local effects rather than by globally modifying the conformational flexibility of HA. Our findings indicate that StRAb binding to HA is precarious, raising the possibility that sufficient immune pressure on the HA stem region could select for viral escape mutants with increased steric hindrance from N-linked glycans. C1 [Magadan, Javier G.; Altman, Meghan O.; Ince, William L.; Hickman, Heather D.; Bennink, Jack R.; Yewdell, Jonathan W.] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA. [Stevens, James] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Chevalier, Aaron; Baker, David] Univ Washington, Dept Biochem, Seattle, WA 98195 USA. [Wilson, Patrick C.] Univ Chicago, Knapp Ctr Lupus & Immunol Res, Dept Med, Sect Rheumatol,Comm Immunol, Chicago, IL 60637 USA. [Ahmed, Rafi] Emory Univ, Sch Med, Dept Microbiol & Immunol, Emory Vaccine Ctr, Atlanta, GA 30322 USA. RP Magadan, JG (reprint author), NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA. EM jyewdell@niaid.nih.gov RI Altman, Meghan/J-2975-2015 OI Altman, Meghan/0000-0002-8910-9074 FU Division of Intramural Research of the National Institute of Allergy and Infectious Diseases FX This work was supported by the Division of Intramural Research of the National Institute of Allergy and Infectious Diseases. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 62 TC 2 Z9 2 U1 2 U2 9 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7366 EI 1553-7374 J9 PLOS PATHOG JI PLoS Pathog. PD JUN PY 2014 VL 10 IS 6 AR e1004204 DI 10.1371/journal.ppat.1004204 PG 12 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA AK1SV UT WOS:000338197400038 PM 24945804 ER PT J AU Carrieri, M Bartolucci, GB Lee, T Barbero, A Harper, M AF Carrieri, Mariella Bartolucci, Giovanni Battista Lee, Taekhee Barbero, Ana Harper, Martin TI Chemical Markers of Occupational Exposure to Teak Wood Dust SO ANNALS OF OCCUPATIONAL HYGIENE LA English DT Article DE deoxylapachol; lapachol; occupational exposure; teak dust; wood dust ID TECTONA-GRANDIS; CONTACT-DERMATITIS; ANTIFUNGAL ACTIVITY; SINONASAL CANCER; NASAL CAVITY; LAPACHOL; NAPHTHOQUINONES; ANTIBACTERIAL; QUINONES; PLANTS AB A novel high-performance liquid chromatographic/ultraviolet method was developed to detect lapachol (LP) and deoxylapachol (DLP) in wood dust as chemical markers of teak wood (a suspected human carcinogen). The specificity of this analysis was determined by noting the absence of LP and DLP in 12 other specimens of different woods belonging to the angiosperm family. The consistency was examined by analyzing teak from three different sources, where the percentages (wt/wt) of the chemicals ranged from 0.006 to 0.261 for LP and from 0.038 to 0.497 for DLP, respectively. Although the LP and DLP components of teak varied according to source, a very high correlation coefficient (r(2) > 0.98 always) was found between the content of the two markers in the bulk specimens and in bulk dust derived from them. The method was then applied to teak dust collected on polyvinylchloride filters from aerosol in an exposure chamber in the range of mass loadings between 0.03 and 3.65 mg, which corresponds to a dust exposure between 0.124 and 8.703 mg m(-3) for a sampling time of 2 h. A field test was also carried out in a small factory where teak was used. A good correlation was confirmed between LP and DLP versus the dust collected on the filter in both cases. LP and DLP can be markers to estimate the true quantities of teak dust inhaled in a workplace with mixed wood dust, provided the results are matched to the content of LP and DLP in the bulk wood. LP and DLP have also been proposed as the agents responsible for allergic reaction to teak dust. Therefore, it would be useful to evaluate the exposure to these two substances even without a relationship to teak dust exposure. C1 [Carrieri, Mariella; Bartolucci, Giovanni Battista] Univ Padua, Dept Cardiol Thorac & Vasc Sci, I-35128 Padua, Italy. [Lee, Taekhee; Barbero, Ana; Harper, Martin] NIOSH, Exposure Assessment Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. RP Carrieri, M (reprint author), Univ Padua, Dept Cardiol Thorac & Vasc Sci, Via Giustiniani 2, I-35128 Padua, Italy. EM mariella.carrieri@unipd.it FU INAIL - The Workers Compensation Authority [15/2009] FX This work was partly supported by INAIL - The Workers Compensation Authority (15/2009). NR 36 TC 1 Z9 1 U1 0 U2 7 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0003-4878 EI 1475-3162 J9 ANN OCCUP HYG JI Ann. Occup. Hyg. PD JUN PY 2014 VL 58 IS 5 BP 566 EP 578 DI 10.1093/annhyg/meu016 PG 13 WC Public, Environmental & Occupational Health; Toxicology SC Public, Environmental & Occupational Health; Toxicology GA AK0MN UT WOS:000338107300004 PM 24671613 ER PT J AU Vo, E Zhuang, ZQ Birch, E Zhao, Q Horvatin, M Liu, YW AF Vo, Evanly Zhuang, Ziqing Birch, Eileen Zhao, Qi Horvatin, Matthew Liu, Yuewei TI Measurement of Mass-Based Carbon Nanotube Penetration through Filtering Facepiece Respirator Filtering Media SO ANNALS OF OCCUPATIONAL HYGIENE LA English DT Article DE aerosol respirator testing system; elemental carbon; filtering facepiece respirators; mass-based penetration; multiwalled carbon nanotubes; single-walled carbon nanotubes ID OCCUPATIONAL-EXPOSURE ASSESSMENT; ELEMENTAL CARBON; SECONDARY MANUFACTURERS; NANOFIBER PRIMARY; PULMONARY; AEROSOL; SYSTEM; MICE; PERFORMANCE; RESPONSES AB Recent studies suggest that a wide range of human health effects could result from exposure to carbon nanotubes (CNTs). A National Institute for Occupational Safety and Health survey of the carbonaceous nanomaterial industry found that 77% of the companies used respiratory protection, such as filtering facepiece respirators (FFRs). Despite CNT studies in some occupational settings being reported, the literature for mass-based penetration of CNTs through FFRs is lacking. The aim of this study was to conduct a quantitative study of single-walled CNT (SWCNT) and multiwalled CNT (MWCNT) penetration through FFRs. A CNT aerosol respirator testing system was used to generate charge-neutralized airborne SWCNTs and MWCNTs for this study. The size distribution was 20-10 000 nm, with 99% of the particles between 25 and 2840 nm. Mass median diameters were 598 and 634 nm with geometric standard deviations of 1.34 and 1.48 for SWCNTs and MWCNTs, respectively. Upstream and downstream CNTs were collected simultaneously using closed-face 3.7-cm-diameter filter cassettes. These samples were subsequently analyzed for organic carbon and elemental carbon (EC), with EC as a measure of mass-based CNTs. The mass-based penetration of SWCNTs and MWCNTs through six FFR models at constant flow rates of 30 l min(-1) (LPM) was determined. Generally, the penetrations of SWCNTs and MWCNTs at 30 LPM had a similar trend and were highest for the N95 FFRs, followed by N99 and P100 FFRs. The mass-based penetration of MWCNTs through six FFR models at two constant flow rates of 30 and 85 LPM was also determined. The penetration of MWCNTs at 85 LPM was greater compared with the values of MWCNTs at 30 LPM. C1 [Vo, Evanly; Zhuang, Ziqing; Liu, Yuewei] NIOSH, Natl Personal Protect Technol Lab, Pittsburgh, PA 15236 USA. [Birch, Eileen; Zhao, Qi] NIOSH, Div Appl Res & Technol, Cincinnati, OH 45226 USA. [Horvatin, Matthew] URS Corp, Pittsburgh, PA 15236 USA. RP Vo, E (reprint author), NIOSH, Natl Personal Protect Technol Lab, 626 Cochrans Mill Rd,POB 18070, Pittsburgh, PA 15236 USA. EM eav8@cdc.gov RI Zhuang, Ziqing/K-5462-2012 NR 33 TC 3 Z9 3 U1 2 U2 14 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0003-4878 EI 1475-3162 J9 ANN OCCUP HYG JI Ann. Occup. Hyg. PD JUN PY 2014 VL 58 IS 5 BP 646 EP 656 DI 10.1093/annhyg/meu005 PG 11 WC Public, Environmental & Occupational Health; Toxicology SC Public, Environmental & Occupational Health; Toxicology GA AK0MN UT WOS:000338107300010 PM 24802251 ER PT J AU Harper, M Key-Schwartz, R AF Harper, Martin Key-Schwartz, Rosa TI Analysis of Crystalline Silica in Bulk Materials SO ANNALS OF OCCUPATIONAL HYGIENE LA English DT Letter C1 [Harper, Martin] NIOSH, Exposure Assessment Branch, Hlth Effects Lab Div, Morgantown, WV 26505 USA. [Key-Schwartz, Rosa] NIOSH, Div Appl Res & Technol, Cincinnati, OH 45226 USA. RP Harper, M (reprint author), NIOSH, Exposure Assessment Branch, Hlth Effects Lab Div, 1095 Willowdale Rd,MS-3030, Morgantown, WV 26505 USA. EM mharper@cdc.gov; rjk9@cdc.gov NR 4 TC 1 Z9 1 U1 1 U2 2 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0003-4878 EI 1475-3162 J9 ANN OCCUP HYG JI Ann. Occup. Hyg. PD JUN PY 2014 VL 58 IS 5 BP 657 EP 658 DI 10.1093/annhyg/meu020 PG 2 WC Public, Environmental & Occupational Health; Toxicology SC Public, Environmental & Occupational Health; Toxicology GA AK0MN UT WOS:000338107300011 PM 24681562 ER PT J AU Skuladottir, H Wilcox, AJ Ma, C Lammer, EJ Rasmussen, SA Werler, MM Shaw, GM Carmichael, SL AF Skuladottir, Hildur Wilcox, Allen J. Ma, Chen Lammer, Edward J. Rasmussen, Sonja A. Werler, Martha M. Shaw, Gary M. Carmichael, Suzan L. TI Corticosteroid Use and Risk of Orofacial Clefts SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Article DE orofacial clefts; cleft lip and palate; corticosteroids; birth defects; pregnancy ID BIRTH-DEFECTS PREVENTION; TOPICAL CORTICOSTEROIDS; ORAL CLEFTS; DRUG-USE; PREGNANCY; PALATE; EXPOSURE; LIP AB Background: Maternal use of corticosteroids during early pregnancy has been inconsistently associated with orofacial clefts in the offspring. A previous report from the National Birth Defect Prevention Study (NBDPS), using data from 1997 to 2002, found an association with cleft lip and palate (odds ratio, 1.7; 95% confidence interval [CI], 1.1-2.6), but not cleft palate only (odds ratio, 0.5, 95% CI, 0.2-1.3). From 2003 to 2009, the study population more than doubled in size, and our objective was to assess this association in the more recent data. Methods: The NBDPS is an ongoing multi-state population-based case-control study of birth defects, with ascertainment of cases and controls born since 1997. We assessed the association of corticosteroids and orofacial clefts using data from 2372 cleft cases and 5922 controls born from 2003 to 2009. Maternal corticosteroid exposure was based on telephone interviews. Results: The overall association of corticosteroids and cleft lip and palate in the new data was 1.0 (95% CI, 0.7-1.4). There was little evidence of associations between specific corticosteroid components or timing and clefts. Conclusion: In contrast to the 1997 to 2002 data from the NBDPS, the 2003 to 2009 data show no association between maternal corticosteroid use and cleft lip and palate in the offspring. (C) 2014 The Authors Birth Defects Research Part A: Clinical and Molecular Teratology Published by Wiley Periodicals, Inc. C1 [Skuladottir, Hildur] Haukeland Hosp, Dept Plast Surg, N-5021 Bergen, Norway. [Skuladottir, Hildur] Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5020 Bergen, Norway. [Wilcox, Allen J.] NIEHS, NIH, Durham, NC USA. [Ma, Chen; Shaw, Gary M.; Carmichael, Suzan L.] Stanford Univ, Dept Pediat, Div Neonatol & Dev Med, Sch Med, Stanford, CA 94305 USA. [Lammer, Edward J.] Childrens Hosp Oakland Res Inst, Oakland, CA USA. [Rasmussen, Sonja A.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Werler, Martha M.] Boston Univ, Slone Epidemiol Ctr, Boston, MA 02215 USA. RP Skuladottir, H (reprint author), Haukeland Hosp, Dept Plast Surg, Jonas Lies Vei 67, N-5021 Bergen, Norway. EM hildur.skuladottir@gmail.com OI Wilcox, Allen/0000-0002-3376-1311 FU NCBDD CDC HHS [U01-DD-001033, U01-DD-000489] NR 24 TC 12 Z9 12 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD JUN PY 2014 VL 100 IS 6 BP 499 EP 506 DI 10.1002/bdra.23248 PG 8 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA AJ9MU UT WOS:000338036300006 PM 24777675 ER PT J AU Lewin, AB Mink, JW Bitsko, RH Holbrook, JR Parker-Athill, EC Hanks, C Storch, EA Augustine, EF Adams, HR Vierhile, AE Thatcher, AR Murphy, TK AF Lewin, Adam B. Mink, Jonathan W. Bitsko, Rebecca H. Holbrook, Joseph R. Parker-Athill, E. Carla Hanks, Camille Storch, Eric A. Augustine, Erika F. Adams, Heather R. Vierhile, Amy E. Thatcher, Alyssa R. Murphy, Tanya K. TI Utility of the Diagnostic Interview Schedule for Children for Assessing Tourette Syndrome in Children SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY LA English DT Article ID TIC DISORDERS; DISC-IV; ADOLESCENTS; RELIABILITY; SEVERITY; PARENT; POPULATION; PREVALENCE AB Objective: The Diagnostic Interview Schedule for Children IV (DISC) has been used extensively in research and screening. Despite wide use, little information exists on the validity of the DISC for diagnosing tic disorders. Methods: Participants were 181 youth with expert clinician-diagnosed Tourette syndrome (TS). Results: Using expert clinician-diagnosed TS as the gold standard, the sensitivity of the DISC-Y (youth, 0.27) and DISC-P (parent, 0.44) was poor. The DISC-Y identified 29.7% of youth with diagnosed TS whereas the DISC-P identified 47.4% of cases. Only 54% of cases of TS were detected by either the DISC-Y or -P. Diagnostic agreement between the DISC and expert clinician diagnosis was poor. The DISC-Y/P results did not differ as a function of tic severity. Conclusions: Despite utility for assessing child psychiatric disorders, the sensitivity of the DISC for detecting TS appears poor. This study suggests that DISC has low agreement with expert clinician diagnosis of TS. Findings highlight the need for modification of the DISC and/or the identification and development of more sensitive measures for TS screening. C1 [Lewin, Adam B.; Parker-Athill, E. Carla; Hanks, Camille; Storch, Eric A.; Murphy, Tanya K.] Univ S Florida, Dept Pediat, St Petersburg, FL 33701 USA. [Lewin, Adam B.; Parker-Athill, E. Carla; Hanks, Camille; Storch, Eric A.; Murphy, Tanya K.] Univ S Florida, Dept Psychiat Behav Neurosci, St Petersburg, FL 33701 USA. [Mink, Jonathan W.; Augustine, Erika F.; Adams, Heather R.; Vierhile, Amy E.; Thatcher, Alyssa R.] Univ Rochester, Dept Neurol, Rochester, NY USA. [Bitsko, Rebecca H.; Holbrook, Joseph R.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Lewin, AB (reprint author), USF Pediat, 880 6th St South Suite 460 Box 7523, St Petersburg, FL 33701 USA. EM alewin@health.usf.edu FU Centers for Disease Control and Prevention [U01DD000509, U01DD000510] FX This study was sponsored by Centers for Disease Control and Prevention cooperative agreements U01DD000509 (TKM) and U01DD000510 (JWM). The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 36 TC 1 Z9 1 U1 4 U2 8 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1044-5463 EI 1557-8992 J9 J CHILD ADOL PSYCHOP JI J. Child Adolesc. Psychopharmacol. PD JUN PY 2014 VL 24 IS 5 BP 275 EP 284 DI 10.1089/cap.2013.0128 PG 10 WC Pediatrics; Pharmacology & Pharmacy; Psychiatry SC Pediatrics; Pharmacology & Pharmacy; Psychiatry GA AJ9EP UT WOS:000338010400007 PM 24813854 ER PT J AU Athey, TBT Teatero, S Li, AM Marchand-Austin, A Beall, BW Fittipaldi, N AF Athey, Taryn B. T. Teatero, Sarah Li, Aimin Marchand-Austin, Alex Beall, Bernard W. Fittipaldi, Nahuel TI Deriving Group A Streptococcus Typing Information from Short-Read Whole-Genome Sequencing Data SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID HORIZONTAL GENE-TRANSFER; EMM-LIKE GENES; M-PROTEIN; OPACITY-FACTOR; PYOGENES; PATHOGENESIS; EVOLUTION; DISEASE; BINDING; CLONE AB Typing of group A Streptococcus (GAS) is crucial for infection control and epidemiology. While whole-genome sequencing (WGS) is revolutionizing the way that bacterial organisms are typed, it is necessary to provide backward compatibility with currently used typing schemas to facilitate comparisons and understanding of epidemiological trends. Here, we sequenced the genomes of 191 GAS isolates representing 42 different emm types and used bioinformatics tools to derive commonly used GAS typing information directly from the short-read WGS data. We show that emm typing and multilocus sequence typing can be achieved rapidly and efficiently using this approach, which also permits the determination of the presence or absence of genes associated with GAS tissue tropism. We also report on how the WGS data analysis was instrumental in identifying ambiguities present in the commonly used emm type database hosted by the U.S. Centers for Disease Control and Prevention. C1 [Athey, Taryn B. T.; Teatero, Sarah; Li, Aimin; Marchand-Austin, Alex; Fittipaldi, Nahuel] Publ Hlth Ontario, Toronto, ON, Canada. [Marchand-Austin, Alex; Fittipaldi, Nahuel] Univ Toronto, Fac Med, Dept Lab Med & Pathobiol, Toronto, ON, Canada. [Beall, Bernard W.] Ctr Dis Control & Prevent, Resp Dis Branch, Atlanta, GA USA. RP Fittipaldi, N (reprint author), Publ Hlth Ontario, Toronto, ON, Canada. EM nahuel.fittipaldi@oahpp.ca OI Marchand-Austin, Alex/0000-0001-5932-2037 FU Public Health Ontario FX This work was funded by Public Health Ontario. NR 34 TC 8 Z9 8 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JUN PY 2014 VL 52 IS 6 BP 1871 EP 1876 DI 10.1128/JCM.00029-14 PG 6 WC Microbiology SC Microbiology GA AJ7YZ UT WOS:000337919500010 PM 24648555 ER PT J AU Yakrus, MA Driscoll, J Lentz, AJ Sikes, D Hartline, D Metchock, B Starks, AM AF Yakrus, Mitchell A. Driscoll, Jeffrey Lentz, Allison J. Sikes, David Hartline, Denise Metchock, Beverly Starks, Angela M. TI Concordance between Molecular and Phenotypic Testing of Mycobacterium tuberculosis Complex Isolates for Resistance to Rifampin and Isoniazid in the United States SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID STRAINS AB Multidrug-resistant (MDR) isolates of Mycobacterium tuberculosis complex (MTBC) are defined by resistance to at least rifampin (RMP) and isoniazid (INH). Rapid and accurate detection of multidrug resistance is essential for effective treatment and interruption of disease transmission of tuberculosis (TB). Overdiagnosis of MDR TB may result in treatment with second-line drugs that are more costly, less effective, and more poorly tolerated than first-line drugs. CDC offers rapid confirmation of MDR TB by the molecular detection of drug resistance (MDDR) for mutations associated with resistance to RMP and INH along with analysis for resistance to other first-line and second-line drugs. Simultaneously, CDC does growth-based phenotypic drug susceptibility testing (DST) by the indirect agar proportion method for a panel of first-line and second-line antituberculosis drugs. We reviewed discordance between molecular and phenotypic DST for INH and RMP for 285 isolates submitted as MTBC to CDC from September 2009 to February 2011. We compared CDC's results with those from the submitting public health laboratories (PHL). Concordances between molecular and phenotypic testing at CDC were 97.4% for RMP and 92.5% for INH resistance. Concordances between CDC's molecular testing and PHL DST results were 93.9% for RMP and 90.0% for INH. Overall concordance between CDC molecular and PHL DST results was 91.7% for RMP and INH collectively. Discordance was primarily attributable to the absence of known INH resistance mutations in isolates found to be INH resistant by DST and detection of mutations associated with low-level RMP resistance in isolates that were RMP susceptible by phenotypic DST. Both molecular and phenotypic test results should be considered for the diagnosis of MDR TB. C1 [Yakrus, Mitchell A.; Driscoll, Jeffrey; Lentz, Allison J.; Sikes, David; Hartline, Denise; Metchock, Beverly; Starks, Angela M.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Yakrus, MA (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. EM may2@cdc.gov NR 12 TC 3 Z9 3 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JUN PY 2014 VL 52 IS 6 BP 1932 EP 1937 DI 10.1128/JCM.00417-14 PG 6 WC Microbiology SC Microbiology GA AJ7YZ UT WOS:000337919500018 PM 24648563 ER PT J AU Lim, SM Brault, AC van Amerongen, G Sewbalaksing, VD Osterhaus, ADME Martina, BEE Koraka, P AF Lim, Stephanie M. Brault, Aaron C. van Amerongen, Geert Sewbalaksing, Varsha D. Osterhaus, Albert D. M. E. Martina, Byron E. E. Koraka, Penelope TI Susceptibility of European jackdaws (Corvus monedula) to experimental infection with lineage 1 and 2 West Nile viruses SO JOURNAL OF GENERAL VIROLOGY LA English DT Article ID NEW-YORK; AMERICAN CROWS; PATHOGENICITY; TRANSMISSION; VIRULENCE; MOSQUITOS; OUTBREAK; STRAINS; HUMANS; BIRDS AB Mass bird mortality has been observed in North America after the introduction of West Nile virus (WNV), most notably massive die-offs of American crows (Corvus brachyrhynchos). In contrast, WNV epidemic activity in Europe has been characterized by very low incidences of bird mortality. As the general susceptibility of European corvids to strains of WNV remains in question, European jackdaws (Corvus monedula) were inoculated with WNV strains circulating currently in Greece (Greece-10), Italy (FIN and Ita09) and Hungary (578/10), as well as a North American (NY99) genotype with a demonstrated corvid virulence phenotype. Infection with all strains except WNV-FIN resulted in mortality. Viraemia was observed for birds inoculated with all strains and virus was detected in a series of organs upon necropsy. These results suggested that jackdaws could potentially function as a sentinel for following WNV transmission in Europe; however, elicited viraemia levels might be too low to allow for efficient transmission of virus to mosquitoes. C1 [Lim, Stephanie M.; van Amerongen, Geert; Sewbalaksing, Varsha D.; Osterhaus, Albert D. M. E.; Martina, Byron E. E.; Koraka, Penelope] Erasmus MC, Dept Virosci, Rotterdam, Netherlands. [Brault, Aaron C.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA. RP Koraka, P (reprint author), Erasmus MC, Dept Virosci, Rotterdam, Netherlands. EM p.koraka@erasmusmc.nl FU European Community [261466] FX We thank Vittorio Sambri, Luisa Barzon, Giorgio Palu and Tamas Bakonyi for providing the low-passage isolates used in this study. We would also like to thank Tanja Schouten and Angela Gomersbach for their excellent technical assistance. We thank Jeroen Roose and Peter van Run for their technical assistance with the immunohistochemistry, and Thijs Kuiken for his assistance with the analysis of the histological staining. The research leading to these results has received complete funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under the project 'VECTORIE' (EC grant agreement 261466). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. Permission for trapping European jackdaws was obtained from the Ministry of Agriculture (registered under number FF/75A/2011/031). Experimental inoculations were performed under protocol number 122-12-12 with permission obtained from the Animal Ethics Committee of Erasmus Medical Centre. All efforts were made to minimize animal suffering. NR 38 TC 9 Z9 9 U1 3 U2 13 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 0022-1317 EI 1465-2099 J9 J GEN VIROL JI J. Gen. Virol. PD JUN PY 2014 VL 95 BP 1320 EP 1329 DI 10.1099/vir.0.063651-0 PN 6 PG 10 WC Biotechnology & Applied Microbiology; Virology SC Biotechnology & Applied Microbiology; Virology GA AK1LN UT WOS:000338176700013 PM 24671752 ER PT J AU Corrigan, JD Kreider, S Cuthbert, J Whyte, J Dams-O'Connor, K Faul, M Harrison-Felix, C Whiteneck, G Pretz, CR AF Corrigan, John D. Kreider, Scott Cuthbert, Jeffrey Whyte, John Dams-O'Connor, Kristen Faul, Mark Harrison-Felix, Cynthia Whiteneck, Gale Pretz, Christopher R. TI Components of Traumatic Brain Injury Severity Indices SO JOURNAL OF NEUROTRAUMA LA English DT Article DE AIS; Barell matrix; craniocerebral trauma; GCS; MCA; TBI ID GLASGOW COMA SCALE; PROGNOSTIC VALUE; MOTOR SCORE; HEAD-INJURY; PREDICTION; TOMOGRAPHY; DIAGNOSIS; OUTCOMES AB The purpose of this study was to determine whether there are underlying dimensions common among traditional traumatic brain injury (TBI) severity indices and, if so, the extent to which they are interchangeable when predicting short-term outcomes. This study had an observational design, and took place in United States trauma centers reporting to the National Trauma Data Bank (NTDB). The sample consisted of 77,470 unweighted adult cases reported to the NTDB from 2007 to 2010, with International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) TBI codes. There were no interventions. Severity indices used were the Emergency Department Glasgow Coma Scale (GCS) Total score and each of the subscales for eye opening (four levels), verbal response (five levels), and motor response (six levels); the worst Abbreviated Injury Scale (AIS) severity score for the head (six levels); and the worst Barell index type (three categories). Prediction models were computed for acute care length of stay (days), intensive care unit length of stay (days), hospital discharge status (alive or dead), and, if alive, discharge disposition (home versus institutional). Multiple correspondence analysis (MCA) indicated a two dimensional relationship among items of severity indexes. The primary dimension reflected overall injury severity. The second dimension seemed to capture volitional behavior without the capability for cogent responding. Together, they defined two vectors around which most of the items clustered. A scale that took advantage of the order of items along these vectors proved to be the most consistent index for predicting short-term health outcomes. MCA provided useful insight into the relationships among components of traditional TBI severity indices. The two vector pattern may reflect the impact of injury on different cortical and subcortical networks. Results are discussed in terms of score substitution and the ability to impute missing values. C1 [Corrigan, John D.] Ohio State Univ, Dept Phys Med & Rehabil, Columbus, OH 43210 USA. [Kreider, Scott; Cuthbert, Jeffrey; Harrison-Felix, Cynthia; Whiteneck, Gale; Pretz, Christopher R.] Craig Hosp, Res Dept, Englewood, CO USA. [Dams-O'Connor, Kristen] Albert Einstein Healthcare Network, Moss Rehabil Res Inst, Elkins Pk, PA USA. [Dams-O'Connor, Kristen] Icahn Sch Med Mt Sinai, Dept Rehabil Med, New York, NY 10029 USA. [Faul, Mark] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA. RP Corrigan, JD (reprint author), Ohio State Univ, Dept Phys Med & Rehabil, 480 Med Ctr Dr, Columbus, OH 43210 USA. EM corrigan.1@osu.edu FU Intramural CDC HHS [CC999999] NR 28 TC 3 Z9 3 U1 1 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 1 PY 2014 VL 31 IS 11 BP 1000 EP 1007 DI 10.1089/neu.2013.3145 PG 8 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AJ7RS UT WOS:000337895300002 PM 24521197 ER PT J AU Uejio, CK Hayden, MH Zielinski-Gutierrez, E Lopez, JLR Barrera, R Amador, M Thompson, G Waterman, SH AF Uejio, Christopher K. Hayden, Mary H. Zielinski-Gutierrez, Emily Robles Lopez, Jose Luis Barrera, Roberto Amador, Manuel Thompson, Gregory Waterman, Stephen H. TI BIOLOGICAL CONTROL OF MOSQUITOES IN SCRAP TIRES IN BROWNSVILLE, TEXAS, USA AND MATAMOROS, TAMAULIPAS, MEXICO SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Aedes; Mesocyclops; Toxorhynchites; tires; United States-Mexico border ID MESOCYCLOPS-LONGISETUS COPEPODA; TOXORHYNCHITES-RUTILUS-RUTILUS; LONGITUDINAL DATA-ANALYSIS; AEDES-AEGYPTI; DENGUE; TRANSMISSION; CYCLOPIDAE; CONTAINERS; CYCLOPOIDA; FEVER AB Dengue periodically circulates in southern Texas and neighboring Tamaulipas, Mexico; thus, a closer examination of human and vector ecology at the northern limits of North American transmission may improve prevention activities. Scrap tires produce large mosquito populations and increase the risk of dengue transmission. Some households choose not to pay tire disposal fees, and many tires are illegally dumped in residential areas. Biological control may provide low-cost and environmentally friendly mosquito control. This pilot study evaluated the ability of Mesocyclops longisetus to reduce mosquito populations in existing residential scrap tire piles. Mosquito populations were measured by the number of all mosquito pupae within tires or adult Aedes aegypti and Ae. albopictus near piles. Mesocyclops longisetus-treated piles did not significantly reduce total mosquito pupae (P = 0.07) in Matamoros, Mexico. The study also evaluated the efficacy of native Toxorhynchites moctezuma which preferentially colonized tire piles under vegetation cover in Brownsville, TX. Toxorhynchites moctezuma larvae significantly reduced total mosquito pupae, but the strength of control diminished over time. C1 [Uejio, Christopher K.] Florida State Univ, Dept Geog, Tallahassee, FL 32306 USA. [Hayden, Mary H.] Natl Ctr Atmospher Res, Res Applicat Lab, Boulder, CO 80307 USA. [Zielinski-Gutierrez, Emily] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. [Barrera, Roberto; Amador, Manuel] Ctr Dis Control & Prevent, Dengue Branch, San Juan, PR 00920 USA. [Thompson, Gregory] New Orleans Mosquito Rodent & Termite Control Boa, New Orleans Mosquito Control Dist, New Orleans, LA 70122 USA. [Waterman, Stephen H.] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, San Diego, CA 92110 USA. RP Uejio, CK (reprint author), Florida State Univ, Dept Geog, 113 Collegiate Loop, Tallahassee, FL 32306 USA. FU Pan American Health Organization/World Health Organization/US Environmental Protection Agency Grant FX We acknowledge the following institutions that aided the project: Jurisdiccion Sanitaria No. III de Matamoros, Brownsville Public Health Department, Harris County Public Health and Environmental Services, and University of Texas School of Public Health-Brownsville. Josh Ramirez, Vicente Anguiano, Victor Herrera, Juan Manuel Becerra Guevara, and Ildefonso Salas assisted with site selection and mosquito collection. We thank Frank Ramberg and Thomas Zavortink for confirming the Toxorhynchites moctezuma identification. This project was funded by the Pan American Health Organization/World Health Organization/US Environmental Protection Agency Grant. NR 33 TC 0 Z9 0 U1 1 U2 16 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X EI 1943-6270 J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD JUN PY 2014 VL 30 IS 2 BP 130 EP 135 PG 6 WC Entomology SC Entomology GA AK0GN UT WOS:000338091000010 PM 25102598 ER PT J AU Yi, SH Baggs, J Gould, CV Scott, RD Jernigan, JA AF Yi, Sarah H. Baggs, James Gould, Carolyn V. Scott, Robert D., II Jernigan, John A. TI Medicare Reimbursement Attributable to Catheter-associated Urinary Tract Infection in the Inpatient Setting A Retrospective Cohort Analysis SO MEDICAL CARE LA English DT Article DE catheter-associated urinary tract infection; Medicare; reimbursement; health care-associated infection; claims data; health care costs; mortality; regression analysis ID NETWORK NHSN REPORT; SURGICAL PATIENTS; CARE; COSTS; BENEFICIARIES; MORTALITY AB Background:Most catheter-associated urinary tract infections (CAUTIs) are considered preventable and thus a potential target for health care quality improvement and cost savings.Objectives:We sought to estimate excess Medicare reimbursement, length of stay, and inpatient death associated with CAUTI among hospitalized beneficiaries.Research Design:Using a retrospective cohort design with linked Medicare inpatient claims and National Healthcare Safety Network data from 2009, we compared Medicare reimbursement between Medicare beneficiaries with and without CAUTIs.Subjects:Fee-for-service Medicare beneficiaries aged 65 years or older with continuous coverage of parts A (hospital insurance) and B (supplementary medical insurance).Results:We found that beneficiaries with CAUTI had higher median Medicare reimbursement [intensive care unit (ICU): $8548, non-ICU: $1479) and length of stay (ICU: 8.1 d, non-ICU: 3.6 d) compared with those without CAUTI controlling for potential confounding factors. Odds of inpatient death were higher among beneficiaries with versus without CAUTI only among those with an ICU stay (ICU: odds ratio 1.37).Conclusions:Beneficiaries with CAUTI had increased Medicare reimbursement and length of stay compared with those without CAUTI after adjusting for potential confounders. C1 [Yi, Sarah H.; Baggs, James; Gould, Carolyn V.; Scott, Robert D., II; Jernigan, John A.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. RP Yi, SH (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, 1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM sarahyi@cdc.gov NR 35 TC 8 Z9 10 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0025-7079 EI 1537-1948 J9 MED CARE JI Med. Care PD JUN PY 2014 VL 52 IS 6 BP 469 EP 478 DI 10.1097/MLR.0000000000000106 PG 10 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA AJ5LK UT WOS:000337723900002 PM 24699236 ER PT J AU Rasmussen, SA Watson, AK Kennedy, ED Broder, KR Jamieson, DJ AF Rasmussen, Sonja A. Watson, Amelia K. Kennedy, Erin D. Broder, Karen R. Jamieson, Denise J. TI Vaccines and pregnancy: Past, present, and future SO SEMINARS IN FETAL & NEONATAL MEDICINE LA English DT Review DE Newborns; Pregnant women; Safety; Vaccine ID IMMUNIZATION PRACTICES ACIP; INFLUENZA VACCINATION COVERAGE; ACELLULAR PERTUSSIS-VACCINE; ADVISORY-COMMITTEE; UNITED-STATES; SEASONAL INFLUENZA; BIRTH-DEFECTS; SPONTANEOUS-ABORTION; PRETERM DELIVERY; ANTHRAX VACCINE AB Vaccination during pregnancy with certain vaccines can prevent morbidity and mortality in pregnant women and their infants. However, previous recommendations often focused on the potential risks of vaccines to the fetus when used during pregnancy. In recent years, additional data have become available on the absence of increased risks for adverse events associated with vaccines when administered during pregnancy and on their benefits to mothers and infants. Currently two vaccines - (i) inactivated influenza, and (ii) tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) - are recommended for use by all pregnant women by the United States Advisory Committee on Immunization Practices. Here we review the history of vaccination during pregnancy, the current status of recommendations for vaccination during pregnancy in the USA, and the potential for future advances in this area, including key barriers that must be overcome to accommodate these advances. Published by Elsevier Ltd. C1 [Rasmussen, Sonja A.] Ctr Dis Control & Prevent, Influenza Coordinat Unit, Off Infect Dis, Atlanta, GA USA. [Watson, Amelia K.] Univ Georgia, Athens, GA 30602 USA. [Kennedy, Erin D.] Ctr Dis Control & Prevent, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Broder, Karen R.] Ctr Dis Control & Prevent, Immunizat Safety Off, Div Healthcare Qual Promot, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. [Jamieson, Denise J.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Rasmussen, SA (reprint author), CDC, 1600 Clifton Rd,MS A-28, Atlanta, GA 30333 USA. EM skr9@cdc.gov OI Rasmussen, Sonja/0000-0002-0574-4928 NR 97 TC 23 Z9 24 U1 0 U2 12 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1744-165X EI 1878-0946 J9 SEMIN FETAL NEONAT M JI Semin. Fetal Neonatal Med. PD JUN PY 2014 VL 19 IS 3 BP 161 EP 169 DI 10.1016/j.siny.2013.11.014 PG 9 WC Pediatrics SC Pediatrics GA AJ8ZQ UT WOS:000337997000004 PM 24355683 ER PT J AU Bartholomew, ML Heffernan, RT Wright, JG Klos, RF Monson, T Khan, S Trees, E Sabol, A Willems, RA Flynn, R Deasy, MP Jones, B Davis, JP AF Bartholomew, Michael L. Heffernan, Richard T. Wright, Jennifer G. Klos, Rachel F. Monson, Timothy Khan, Sofiya Trees, Eija Sabol, Ashley Willems, Robert A. Flynn, Raymond Deasy, Marshall P. Jones, Benjamen Davis, Jeffrey P. TI Multistate Outbreak of Salmonella enterica Serotype Enteritidis Infection Associated with Pet Guinea Pigs SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Salmonellosis; Salmonella enteritidis; Guinea pigs ID FIELD GEL-ELECTROPHORESIS; UNITED-STATES; EXOTIC PETS; TYPHIMURIUM; CONTACT; ILLNESS; TRANSPORTATION; FOOD AB Salmonella causes about one million illnesses annually in the United States. Although most infections result from foodborne exposures, animal contact is an important mode of transmission. We investigated a case of Salmonella enterica serotype Enteritidis (SE) sternal osteomyelitis in a previously healthy child who cared for two recently deceased guinea pigs (GPs). A case was defined as SE pulsed-field gel electrophoresis (PFGE) XbaI pattern JEGX01.0021, BlnI pattern JEGA26.0002 (outbreak strain) infection occurring during 2010 in a patient who reported GP exposure. To locate outbreak strain isolates, PulseNet and the US Department of Agriculture National Veterinary Service Laboratories (NVSL) databases were queried. Outbreak strain isolates underwent multilocus variable-number tandem repeat analysis (MLVA). Traceback and environmental investigations were conducted at homes, stores, and breeder or broker facilities. We detected 10 cases among residents of eight states and four NVSL GP outbreak strain isolates. One patient was hospitalized; none died. The median patient age was 9.5 (range, 1-61) years. Among 10 patients, two purchased GPs at independent stores, and three purchased GPs at different national retail chain (chain A) store locations; three were chain A employees and two reported GP exposures of unknown characterization. MLVA revealed four related patterns. Tracebacks identified four distributors and 92 sources supplying GPs to chain A, including one breeder potentially supplying GPs to all case-associated chain A stores. All environmental samples were Salmonella culture-negative. A definitive SE-contaminated environmental source was not identified. Because GPs can harbor Salmonella, consumers and pet industry personnel should be educated regarding risks. C1 [Bartholomew, Michael L.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. [Bartholomew, Michael L.] Ctr Dis Control & Prevent, Sci Educ & Profess Dev Program Off, Atlanta, GA USA. [Bartholomew, Michael L.] Ctr Dis Control & Prevent, Off Surveillance Epidemiol & Lab Serv, Atlanta, GA USA. [Bartholomew, Michael L.; Heffernan, Richard T.; Klos, Rachel F.; Davis, Jeffrey P.] Wisconsin Div Publ Hlth, Madison, WI 53701 USA. [Wright, Jennifer G.; Khan, Sofiya; Trees, Eija; Sabol, Ashley] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. [Monson, Timothy] Univ Wisconsin, Wisconsin State Lab Hyg, Madison, WI 53706 USA. [Willems, Robert A.; Flynn, Raymond] Anim & Plant Hlth Inspect Serv, USDA, Raleigh, NC USA. [Deasy, Marshall P.] Penn Dept Hlth, Harrisburg, PA 17108 USA. [Jones, Benjamen] Waukesha Cty Hlth & Human Serv Dept, Publ Hlth Div, Waukesha, WI USA. RP Bartholomew, ML (reprint author), Wisconsin Div Publ Hlth, 1 West Wilson St,Room 318, Madison, WI 53701 USA. EM michael.l.bartholomew@gmail.com FU Wisconsin Division of Public Health; Center for Disease Control and Prevention's Public Health Emergency Response; Center for Epidemiology and Laboratory Capacity FX This work is dedicated in memory of Richard Thomas Burch Heffernan, a dedicated epidemiologist, trusted colleague, strong leader, mentor, and dear friend. We are indebted to the many local and state public health officials, clinicians, infection preventionists, and laboratory staff who submitted case reports and provided information to support this investigation. This work was supported by the Wisconsin Division of Public Health with funding from the Centers for Disease Control and Prevention's Public Health Emergency Response and Epidemiology and Laboratory Capacity cooperative agreements. NR 36 TC 5 Z9 5 U1 0 U2 15 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 EI 1557-7759 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD JUN PY 2014 VL 14 IS 6 BP 414 EP 421 DI 10.1089/vbz.2013.1506 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AJ8MI UT WOS:000337958500006 PM 24866204 ER PT J AU Denny, CH Hungerford, DW McKnight-Eily, LR Green, PP Dang, EP Cannon, MJ Cheal, NE Sniezek, J AF Denny, C. H. Hungerford, D. W. McKnight-Eily, L. R. Green, P. P. Dang, E. P. Cannon, M. J. Cheal, N. E. Sniezek, J. TI SELF-REPORTED PREVALENCE OF SCREENING FOR ALCOHOL MISUSE AMONG UNITED STATES ADULTS SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Meeting Abstract CT 37th Annual Scientific Meeting of the Research-Society-on-Alcoholism (RSA) / 17th Congress of the International-Society-for-Biomedical-Research-on-Alcoholism (ISBRA) CY JUN 21-25, 2014 CL Bellevue, WA SP Res Soc Alcoholism, Int Soc Biomed Res Alcoholism C1 [Denny, C. H.; Hungerford, D. W.; McKnight-Eily, L. R.; Green, P. P.; Dang, E. P.; Cannon, M. J.; Cheal, N. E.; Sniezek, J.] Ctr Dis Control & Prevent, Prevent Res Branch, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD JUN PY 2014 VL 38 SU 1 SI SI MA 0821 BP 206A EP 206A PG 1 WC Substance Abuse SC Substance Abuse GA AJ2VX UT WOS:000337523701021 ER PT J AU Elliott, JC Aharonovich, E O'Leary, A Johnston, B Hasin, DS AF Elliott, J. C. Aharonovich, E. O'Leary, A. Johnston, B. Hasin, D. S. TI PERCEIVED MEDICAL RISKS OF DRINKING AMONG HIV-INFECTED PATIENTS WITH AND WITHOUT HEPATITIS C SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Meeting Abstract CT 37th Annual Scientific Meeting of the Research-Society-on-Alcoholism (RSA) / 17th Congress of the International-Society-for-Biomedical-Research-on-Alcoholism (ISBRA) CY JUN 21-25, 2014 CL Bellevue, WA SP Res Soc Alcoholism, Int Soc Biomed Res Alcoholism C1 Columbia Univ, Med Ctr, New York, NY 10032 USA. Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD JUN PY 2014 VL 38 SU 1 SI SI MA 1082 BP 271A EP 271A PG 1 WC Substance Abuse SC Substance Abuse GA AJ2VX UT WOS:000337523701281 ER PT J AU Doligalski, CT Benedict, K Cleveland, AA Park, B Derado, G Pappas, PG Baddley, JW Zaas, DW Harris, MT Alexander, BD AF Doligalski, C. T. Benedict, K. Cleveland, A. A. Park, B. Derado, G. Pappas, P. G. Baddley, J. W. Zaas, D. W. Harris, M. T. Alexander, B. D. TI Epidemiology of Invasive Mold Infections in Lung Transplant Recipients SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Article DE Epidemiology; infection; lung transplant; mold ID FUNGAL-INFECTIONS; ANTIFUNGAL PROPHYLAXIS; RISK-FACTORS; ASPERGILLOSIS; STRATEGIES AB Invasive mold infections (IMIs) are a major source of morbidity and mortality among lung transplant recipients (LTRs), yet information regarding the epidemiology of IMI in this population is limited. From 2001 to 2006, multicenter prospective surveillance for IMIs among LTR was conducted by the Transplant-Associated Infection Surveillance Network. The epidemiology of IMI among all LTRs in the cohort is reported. Twelve percent (143/ 1173) of LTRs under surveillance at 15 US centers developed IMI infections. The 12-month cumulative incidence of IMIs was 5.5%; 3-month all-cause mortality was 21.7%. Aspergillus caused the majority (72.7%) of IMIs; non-Aspergillus infections (39, 27.3%) included Scedosporium (5, 3.5%), mucormycosis (3, 2.1%) and "unspecified'' or "other'' mold infections (31, 21.7%). Late-onset IMI was common: 52% occurred within 1 year posttransplant (median 11 months, range 0-162 months). IMIs are common late-onset complications with substantial mortality in LTRs. LTRs should be monitored for late-onset IMIs and prophylactic agents should be optimized based on likely pathogen. C1 [Doligalski, C. T.] Tampa Gen Hosp, Dept Pharm, Tampa, FL 33606 USA. [Benedict, K.; Cleveland, A. A.; Park, B.] US Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA USA. [Derado, G.] US Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Atlanta, GA USA. [Pappas, P. G.; Baddley, J. W.] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA. [Zaas, D. W.; Alexander, B. D.] Duke Univ Hosp, Dept Med, Durham, NC 27710 USA. [Harris, M. T.] Duke Univ Hosp, Dept Pharm, Durham, NC USA. [Alexander, B. D.] Duke Univ Hosp, Dept Pathol, Durham, NC USA. RP Alexander, BD (reprint author), Duke Univ Hosp, Dept Med, Durham, NC 27710 USA. EM Barbara.alexander@duke.edu FU Centers for Disease Control [5U01C1000286-05]; NIH NIAID [K24 AI072522] FX This work was supported in part by the Centers for Disease Control (grant no. 5U01C1000286-05) and NIH NIAID K24 AI072522 (BDA). NR 20 TC 13 Z9 13 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1600-6135 EI 1600-6143 J9 AM J TRANSPLANT JI Am. J. Transplant. PD JUN PY 2014 VL 14 IS 6 BP 1328 EP 1333 DI 10.1111/ajt.12691 PG 6 WC Surgery; Transplantation SC Surgery; Transplantation GA AJ2UP UT WOS:000337519500014 PM 24726020 ER PT J AU Gupte, AA Hocevar, SN Lea, AS Kulkarni, RD Schain, DC Casey, MJ Zendejas-Ruiz, IR Chung, WK Mbaeyi, C Roy, SL Visvesvara, GS da Silva, AJ Tallaj, J Eckhoff, D Baddley, JW AF Gupte, A. A. Hocevar, S. N. Lea, A. S. Kulkarni, R. D. Schain, D. C. Casey, M. J. Zendejas-Ruiz, I. R. Chung, W. K. Mbaeyi, C. Roy, S. L. Visvesvara, G. S. da Silva, A. J. Tallaj, J. Eckhoff, D. Baddley, J. W. TI Transmission of Balamuthia mandrillaris Through Solid Organ Transplantation: Utility of Organ Recipient Serology to Guide Clinical Management SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Article DE Amebic encephalitis; Balamuthia mandrillaris; donor-derived infection; miltefosine ID FREE-LIVING AMEBAS; NAEGLERIA-FOWLERI; ACANTHAMOEBA SPP.; ENCEPHALITIS; MENINGOENCEPHALITIS; PATIENT; INFECTION; AGENT; PCR AB A liver, heart, iliac vessel and two kidneys were recovered from a 39-year-old man who died of traumatic head injury and were transplanted into five recipients. The liver recipient 18 days posttransplantation presented with headache, ataxia and fever, followed by rapid neurologic decline and death. Diagnosis of granulomatous amebic encephalitis was made on autopsy. Balamuthia mandrillaris infection was confirmed with immunohistochemical and polymerase chain reaction (PCR) assays. Donor and recipients' sera were tested for B. mandrillaris antibodies. Donor brain was negative for Balamuthia by immunohistochemistry and PCR; donor serum Balamuthia antibody titer was positive (1:64). Antibody titers in all recipients were positive (range, 1:64-1:512). Recipients received a four-to five-drug combination of miltefosine or pentamidine, azithromycin, albendazole, sulfadiazine and fluconazole. Nausea, vomiting, elevated liver transaminases and renal insufficiency were common. All other recipients survived and have remained asymptomatic 24 months posttransplant. This is the third donor-derived Balamuthia infection cluster described in solid organ transplant recipients in the United States. As Balamuthia serologic testing is only available through a national reference laboratory, it is not feasible for donor screening, but may be useful to determine exposure status in recipients and to help guide chemotherapy. C1 [Gupte, A. A.; Kulkarni, R. D.; Schain, D. C.; Casey, M. J.; Zendejas-Ruiz, I. R.] Univ Florida, Coll Med, Gainesville, FL USA. [Hocevar, S. N.; Mbaeyi, C.; Roy, S. L.; Visvesvara, G. S.; da Silva, A. J.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Lea, A. S.; Chung, W. K.] Univ Texas Med Branch, Galveston, TX 77555 USA. [Tallaj, J.; Eckhoff, D.; Baddley, J. W.] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA. RP Baddley, JW (reprint author), Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA. EM jbaddley@uab.edu FU Intramural CDC HHS [CC999999] NR 25 TC 7 Z9 8 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1600-6135 EI 1600-6143 J9 AM J TRANSPLANT JI Am. J. Transplant. PD JUN PY 2014 VL 14 IS 6 BP 1417 EP 1424 DI 10.1111/ajt.12726 PG 8 WC Surgery; Transplantation SC Surgery; Transplantation GA AJ2UP UT WOS:000337519500024 PM 24840013 ER PT J AU Schafer, IJ Miller, R Stroher, U Knust, B Nichol, ST Rollin, PE AF Schafer, Ilana J. Miller, Rachel Stroeher, Ute Knust, Barbara Nichol, Stuart T. Rollin, Pierre E. TI Notes From the Field: A Cluster of Lymphocytic Choriomeningitis Virus Infections Transmitted Through Organ Transplantation-Iowa, 2013 SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Editorial Material C1 [Schafer, Ilana J.] CDC, Atlanta, GA 30333 USA. [Miller, Rachel] Univ Iowa, Carver Coll Med, Iowa City, IA 52242 USA. [Stroeher, Ute; Knust, Barbara; Nichol, Stuart T.; Rollin, Pierre E.] CDC, Viral Special Pathogens Branch, Natl Ctr Emerging, Atlanta, GA 30333 USA. RP Schafer, IJ (reprint author), CDC, Atlanta, GA 30333 USA. EM ischafer@cdc.gov NR 3 TC 2 Z9 2 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1600-6135 EI 1600-6143 J9 AM J TRANSPLANT JI Am. J. Transplant. PD JUN PY 2014 VL 14 IS 6 BP 1459 EP 1459 DI 10.1111/ajt.12802 PG 1 WC Surgery; Transplantation SC Surgery; Transplantation GA AJ2UP UT WOS:000337519500030 PM 24854024 ER PT J AU Miller, CH Rice, AS Garrett, K Stein, SF AF Miller, Connie H. Rice, Anne S. Garrett, Katherine Stein, Sidney F. TI Gender, race and diet affect platelet function tests in normal subjects, contributing to a high rate of abnormal results SO BRITISH JOURNAL OF HAEMATOLOGY LA English DT Article DE platelets; platelet function tests; platelet aggregation; ristocetin; flavonoids ID LIGHT TRANSMISSION AGGREGOMETRY; REFERENCE INTERVALS; HEALTHY-VOLUNTEERS; AGGREGATION; BLOOD; SEX; INDIVIDUALS; VARIABLES; CONSENSUS; TIME AB To assess sources of variability in platelet function tests in normal subjects, 64 healthy young adults were tested on 2-6 occasions at 2week intervals using four methods: platelet aggregation (AGG) in platelet-rich plasma (PRP) in the Bio/Data PAP-4 Aggregometer (BD) and Chrono-Log Lumi-Aggregometer (CL); and AGG in whole blood (WB) in the CL and Multiplate Platelet Function Analyser (MP), with ATP release (REL) in CL-PRP and CL-WB. Food and medication exposures were recorded prospectively for 2weeks prior to each blood draw. At least one AGG abnormality was seen in 21% of 81 drug-free specimens with CL-PRP, 15% with CL-WB, 13% with BD-PRP and 6% with MP-WB, increasing with inclusion of REL to 28% for CL-PRP and 30% for CL-WB. Epinephrine AGG and REL were significantly reduced in males (P<00001). Ristocetin AGG and collagen and thrombin REL were significantly reduced in Blacks (P<00001). One-third of specimens drawn following flavonoid-rich food exposures had aberrant results, compared to 85% of specimens without such exposures (P=00035). PRP tests had less intra-individual variation than WB tests. Gender, race, diet and test system affected results of platelet function testing in healthy subjects, suggesting caution when interpreting the results of platelet function testing in patients. C1 [Miller, Connie H.; Rice, Anne S.] Ctr Dis Control & Prevent, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Garrett, Katherine; Stein, Sidney F.] Emory Univ, Sch Med, Atlanta, GA USA. RP Miller, CH (reprint author), Ctr Dis Control & Prevent, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS D-02, Atlanta, GA 30333 USA. EM cmiller2@cdc.gov OI Miller, Connie H/0000-0002-3989-7973 FU Association of Teachers of Preventive Medicine FX The study was supported by a cooperative agreement with the Association of Teachers of Preventive Medicine. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 31 TC 7 Z9 8 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0007-1048 EI 1365-2141 J9 BRIT J HAEMATOL JI Br. J. Haematol. PD JUN PY 2014 VL 165 IS 6 BP 842 EP 853 DI 10.1111/bjh.12827 PG 12 WC Hematology SC Hematology GA AJ2UY UT WOS:000337520600014 PM 24617520 ER PT J AU Mesquita, JR Delgado, I Costantini, V Heenemann, K Vahlenkamp, TW Vinje, J Nascimento, MSJ AF Mesquita, Joao R. Delgado, Ines Costantini, Veronica Heenemann, Kristin Vahlenkamp, Thomas W. Vinje, Jan Nascimento, Maria S. J. TI Seroprevalence of Canine Norovirus in 14 European Countries SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID DOGS; OUTBREAK AB To investigate the prevalence of the recently described genogroup VI canine noroviruses (CNVs) in dogs in Europe, we tested 510 serum samples from dogs in 14 European countries for anti-IgG CNV antibodies. Seropositive dogs were found throughout Europe. Dogs with antibodies against human noroviruses were also found. C1 [Mesquita, Joao R.] Polytech Inst, Agrarian Super Sch, Viseu, Portugal. [Mesquita, Joao R.; Nascimento, Maria S. J.] Univ Porto, Ctr Invest Biodiversidade & Recursos Genet, Viseu, Portugal. [Delgado, Ines; Nascimento, Maria S. J.] Univ Porto, Fac Pharm, P-4100 Oporto, Portugal. [Costantini, Veronica; Vinje, Jan] Ctr Dis Control & Prevent, Atlanta, GA USA. [Heenemann, Kristin; Vahlenkamp, Thomas W.] Univ Leipzig, Fac Vet, D-04109 Leipzig, Germany. RP Mesquita, JR (reprint author), Polytech Inst, Agrarian Super Sch, Viseu, Portugal. EM jmesquita@esav.ipv.pt RI Mesquita, Joao/B-6960-2016; OI Mesquita, Joao/0000-0001-8769-8103; Delgado, Ines/0000-0002-7369-2883; Costantini, Veronica/0000-0002-1532-4345 FU FEDER funds through the Programa Operacional Factores de Competividade-COMPETE; Fundacao para a Ciencia e Tecnologia (FCT) [PTDC/CVT/113218/2009]; FCT [SFRH/BD/45407/2008] FX This work was supported by FEDER funds through the Programa Operacional Factores de Competividade-COMPETE and funding through the Fundacao para a Ciencia e Tecnologia (FCT) (project PTDC/CVT/113218/2009). J.R.M. was supported by a Ph.D. grant (SFRH/BD/45407/2008) from the FCT. NR 12 TC 2 Z9 3 U1 2 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 EI 1556-679X J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD JUN PY 2014 VL 21 IS 6 BP 898 EP 900 DI 10.1128/CVI.00048-14 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AJ0NW UT WOS:000337352500016 PM 24671552 ER PT J AU Li, R Barker, LE Shrestha, S Zhang, P Duru, OK Pearson-Clarke, T Gregg, EW AF Li, Rui Barker, Lawrence E. Shrestha, Sundar Zhang, Ping Duru, O. Kenrick Pearson-Clarke, Tony Gregg, Edward W. TI Changes Over Time in High Out-of-Pocket Health Care Burden in US Adults With Diabetes, 2001-2011 SO DIABETES CARE LA English DT Article ID MEDICARE PART D; FINANCIAL BURDEN; EXPENDITURE BURDENS; PRESCRIPTION DRUGS; TRENDS; BENEFICIARIES; POPULATION; COSTS AB OBJECTIVE High out-of-pocket (OOP) costs can be an obstacle to health care access and treatment compliance. This study investigated trends in high OOP health care burden in people with diabetes. RESEARCH DESIGN AND METHODS Using Medical Expenditure Panel Survey 2001-2011 data, we examined trends in the proportion of people aged 18-64 years with diabetes facing a high OOP burden. We also examined whether the trend differed by insurance status (private insurance, public insurance, or no insurance) or by income level (poor and near poor, low income, middle income, or high income). RESULTS In 2011, 23% of people with diabetes faced high OOP burden. Between 2001-2002 and 2011, the proportion of people facing high OOP burden fell by 5 percentage points (P < 0.01). The proportion of those who were publicly insured decreased by 22 percentage points (P < 0.001) and of those who were uninsured by 12 percentage points (P = 0.01). Among people with diabetes who were poor and near poor and those with low income, the proportion facing high OOP burden decreased by 21 (P < 0.001) and 13 (P = 0.01) percentage points, respectively; no significant change occurred in the proportion with private insurance or middle and high incomes between 2001-2002 and 2011. CONCLUSIONS The past decade has seen a narrowing of insurance coverage and income-related disparities in high OOP burden in people with diabetes; yet, almost one-fourth of all people with diabetes still face a high OOP burden. C1 [Li, Rui; Barker, Lawrence E.; Shrestha, Sundar; Zhang, Ping; Pearson-Clarke, Tony; Gregg, Edward W.] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA 30333 USA. [Duru, O. Kenrick] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. RP Li, R (reprint author), Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA 30333 USA. EM eok8@cdc.gov FU Intramural CDC HHS [CC999999] NR 28 TC 6 Z9 6 U1 0 U2 1 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 EI 1935-5548 J9 DIABETES CARE JI Diabetes Care PD JUN PY 2014 VL 37 IS 6 BP 1629 EP 1635 DI 10.2337/dc13-1997 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA AJ5RX UT WOS:000337746100038 PM 24667459 ER PT J AU Tamma, PD Srinivasan, A Cosgrove, SE AF Tamma, Pranita D. Srinivasan, Arjun Cosgrove, Sara E. TI Preface SO INFECTIOUS DISEASE CLINICS OF NORTH AMERICA LA English DT Editorial Material C1 [Tamma, Pranita D.; Cosgrove, Sara E.] Johns Hopkins Univ, Sch Med, Baltimore, MD 21287 USA. [Srinivasan, Arjun] Ctr Dis Control & Prevent, Atlanta, GA 30322 USA. RP Tamma, PD (reprint author), Johns Hopkins Univ, Sch Med, 600 N Wolfe St, Baltimore, MD 21287 USA. EM ptamma1@jhmi.edu; asrinivasan@cdc.gov; scosgro1@jhmi.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0891-5520 EI 1557-9824 J9 INFECT DIS CLIN N AM JI Infect. Dis. Clin. North Am. PD JUN PY 2014 VL 28 IS 2 BP XI EP XII DI 10.1016/j.idc.2014.04.001 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AJ0HE UT WOS:000337330300001 PM 24857396 ER PT J AU Rhee, SM Stone, ND AF Rhee, Susan M. Stone, Nimalie D. TI Antimicrobial Stewardship in Long-term Care Facilities SO INFECTIOUS DISEASE CLINICS OF NORTH AMERICA LA English DT Article DE Long-term care; Antimicrobial stewardship; Antimicrobial resistance; Elderly; Infection prevention ID NURSING-HOME RESIDENTS; URINARY-TRACT-INFECTION; ANTIBIOTIC USE; ASYMPTOMATIC BACTERIURIA; CRITERIA; SURVEILLANCE; INTERVENTION; DEFINITIONS; HOSPITALS; MORTALITY AB Although antimicrobial stewardship has been shown to improve microbiologic susceptibility patterns, decrease drug toxicities, and lower overall drug costs in acute care inpatient, there are few studies assessing programs in the long-term care (LTC) setting. Implementing antimicrobial stewardship programs in LTC settings can be challenging as the LTC setting houses a unique population of frail and older adults with several preexisting conditions and multiple risk factors for colonization with multidrug-resistant organisms. Antimicrobial stewardship has an important role in decreasing inappropriate antibiotic use, encouraging targeted treatment of specific disease states, and limiting the untoward effects and costs of antimicrobials in this vulnerable population. C1 [Rhee, Susan M.] Johns Hopkins Bayview Med Ctr, Div Infect Dis, Baltimore, MD 21224 USA. [Stone, Nimalie D.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. RP Rhee, SM (reprint author), Johns Hopkins Bayview Med Ctr, Div Infect Dis, 5200 Eastern Ave,MFL Ctr Tower,3rd Floor, Baltimore, MD 21224 USA. EM srhee9@jhmi.edu NR 50 TC 11 Z9 11 U1 1 U2 8 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0891-5520 EI 1557-9824 J9 INFECT DIS CLIN N AM JI Infect. Dis. Clin. North Am. PD JUN PY 2014 VL 28 IS 2 BP 237 EP + DI 10.1016/j.idc.2014.01.001 PG 11 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AJ0HE UT WOS:000337330300006 PM 24857390 ER PT J AU Bitsko, RH Holbrook, JR Visser, SN Mink, JW Zinner, SH Ghandour, RM Blumberg, SJ AF Bitsko, Rebecca H. Holbrook, Joseph R. Visser, Susanna N. Mink, Jonathan W. Zinner, Samuel H. Ghandour, Reem M. Blumberg, Stephen J. TI A National Profile of Tourette Syndrome, 2011-2012 SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS LA English DT Article DE epidemiology; prevalence; health care; comorbidity; parenting ID HEALTH-CARE NEEDS; TIC DISORDERS; CHILDREN; PREVALENCE; EPIDEMIOLOGY; COMORBIDITY; RISK AB Objective: To provide recent estimates of the prevalence of Tourette syndrome among a nationally representative sample of US children and to describe the association of Tourette syndrome with indicators of health and functioning. Methods: Data on 65,540 US children aged 6 to 17 years from the 20112012 National Survey of Children's Health were analyzed. Parents reported whether a health care provider had ever told them their child had Tourette syndrome or other neurobehavioral or chronic health conditions and whether their child had current Tourette syndrome. Results: Based on parents' report, 0.19% of US children had Tourette syndrome; the average age of diagnosis was 8.1 years. Children with Tourette syndrome, compared with those without, were more likely to have co-occurring neurobehavioral and other health conditions, meet criteria for designation as having a special health care need, receive mental health treatment, have unmet mental health care needs, and have parents with high parenting aggravation and parents who were contacted about school problems; they were less likely to receive effective care coordination or have a medical home. After controlling for co-occurring neurobehavioral conditions, the findings on parents being contacted about school problems and children having unmet mental health care needs were no longer significant. Conclusions: Tourette syndrome is characterized by co-occurring neurobehavioral and other health conditions, and poorer health, education, and family relationships. The findings support previous recommendations to consider co-occurring conditions in the diagnosis and treatment of Tourette syndrome. Future research may explore whether having a medical home improves outcomes among children with Tourette syndrome. C1 [Bitsko, Rebecca H.; Holbrook, Joseph R.; Visser, Susanna N.] Ctr Dis Control & Prevent, Div Human Dev & Disabil, NCBDDD, Atlanta, GA USA. [Mink, Jonathan W.] Univ Rochester, Dept Neurol, Rochester, NY USA. [Mink, Jonathan W.] Univ Rochester, Dept Neurobiol & Anat, Rochester, NY USA. [Mink, Jonathan W.] Univ Rochester, Dept Brain & Cognit Sci, Rochester, NY USA. [Mink, Jonathan W.] Univ Rochester, Dept Pediat, Rochester, NY USA. [Zinner, Samuel H.] Univ Washington, Dept Pediat, Div Dev Med, Seattle, WA 98195 USA. [Ghandour, Reem M.] Maternal & Child Hlth Bur, Off Epidemiol & Res, US Hlth Resources & Serv Adm, Rockville, MD USA. [Blumberg, Stephen J.] Ctr Dis Control & Prevent, Div Hlth Interview Stat, Natl Ctr Hlth Stat, Hyattsville, MD USA. RP Bitsko, RH (reprint author), CDC, NCBDDD, 1600 Clifton Rd,MS E-88, Atlanta, GA 30333 USA. EM dvk2@cdc.gov FU Intramural CDC HHS [CC999999] NR 34 TC 11 Z9 11 U1 2 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0196-206X EI 1536-7312 J9 J DEV BEHAV PEDIATR JI J. Dev. Behav. Pediatr. PD JUN PY 2014 VL 35 IS 5 BP 317 EP 322 PG 6 WC Behavioral Sciences; Psychology, Developmental; Pediatrics SC Behavioral Sciences; Psychology; Pediatrics GA AJ0PL UT WOS:000337357400002 PM 24906033 ER PT J AU Osadebe, LU Li, Y Damon, IK Reynolds, MG Muyombwe, A Gappy, C AF Osadebe, Lynda U. Li, Yu Damon, Inger K. Reynolds, Mary G. Muyombwe, Anthony Gappy, Christopher TI Ocular Molluscum Contagiosum Atypical Clinical Presentation SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Letter C1 [Osadebe, Lynda U.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Sci Educ & Profess Dev Program Off, DHCPP,Poxvirus & Rabies Branch, Atlanta, GA 30333 USA. [Li, Yu; Damon, Inger K.; Reynolds, Mary G.] Ctr Dis Control & Prevent, DHCPP, Poxvirus & Rabies Branch, Atlanta, GA USA. [Muyombwe, Anthony] Michigan Dept Community Hlth, Bur Labs, Lansing, MI USA. [Gappy, Christopher] Univ Michigan, Kellogg Eye Ctr, Ann Arbor, MI 48109 USA. RP Osadebe, LU (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv, Sci Educ & Profess Dev Program Off, DHCPP,Poxvirus & Rabies Branch, Atlanta, GA 30333 USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0891-3668 EI 1532-0987 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD JUN PY 2014 VL 33 IS 6 BP 668 EP 668 DI 10.1097/INF.0000000000000258 PG 1 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA AJ0OL UT WOS:000337354400030 PM 24830519 ER PT J AU Dharan, NJ Sokolow, LZ Cheng, PY Gargiullo, P Gershman, K Lynfield, R Morin, C Thomas, A Meek, J Farley, MM Arnold, KE Reingold, A Craig, AS Schaffner, W Bennett, NM Zansky, S Baumbach, J Lathrop, S Kamimoto, L Shay, DK AF Dharan, Nila J. Sokolow, Leslie Z. Cheng, Po-Yung Gargiullo, Paul Gershman, Ken Lynfield, Ruth Morin, Craig Thomas, Ann Meek, James Farley, Monica M. Arnold, Kathryn E. Reingold, Arthur Craig, Allen S. Schaffner, William Bennett, Nancy M. Zansky, Shelley Baumbach, Joan Lathrop, Sarah Kamimoto, Laurie Shay, David K. TI Child, Household, and Caregiver Characteristics Associated with Hospitalization for Influenza Among Children 6-59 Months of Age An Emerging Infections Program Study SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE influenza; risk factors; hospitalization; children; household ID RESPIRATORY SYNCYTIAL VIRUS; TEST-NEGATIVE DESIGN; RISK-FACTORS; UNITED-STATES; YOUNG-CHILDREN; INFANTS; SURVEILLANCE; DISPARITIES; DISEASE; VACCINE AB Background: Young children are at increased risk of severe outcomes from influenza illness, including hospitalization. We conducted a case-control study to identify risk factors for influenza-associated hospitalizations among children in US Emerging Infections Program sites. Methods: Cases were children 6-59 months of age hospitalized for laboratory-confirmed influenza infections during 2005-2008. Age- and zip-code-matched controls were enrolled. Data on child, caregiver and household characteristics were collected from parents and medical records. Conditional logistic regression was used to identify independent risk factors for hospitalization. Results: We enrolled 290 (64%) of 454 eligible cases and 1089 (49%) of 2204 eligible controls. Risk for influenza hospitalization increased with maternal age <26 years [odds ratio (OR): 1.8, 95% confidence interval (CI): 1.1-2.9]; household income below the poverty threshold (OR: 2.2, 95% CI: 1.4-3.6); smoking by >50% of household members (OR: 2.9, 95% CI: 1.4-6.6); lack of household influenza vaccination (OR: 1.8, 95% CI: 1.2-2.5) and presence of chronic illnesses, including hematologic/oncologic (OR: 11.8, 95% CI: 4.5-31.0), pulmonary (OR: 2.9, 95% CI: 1.9-4.4) and neurologic (OR: 3.8, 95% CI: 1.6-9.2) conditions. Full influenza immunization decreased the risk among children 6-23 months of age (OR: 0.5, 95% CI: 0.3-0.9) but not among those 24-59 months of age (OR: 1.5, 95% CI: 0.8-3.0; P value for difference = 0.01). Conclusions: Chronic illnesses, young maternal age, poverty, household smoking and lack of household influenza vaccination increased the risk of influenza hospitalization. These characteristics may help providers to identify young children who are at greatest risk for severe outcomes from influenza illness. C1 [Dharan, Nila J.; Sokolow, Leslie Z.; Cheng, Po-Yung; Gargiullo, Paul; Kamimoto, Laurie; Shay, David K.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. [Sokolow, Leslie Z.] Battelle Mem Inst, Atlanta, GA USA. [Gershman, Ken] Colorado Dept Publ Hlth & Environm, Denver, CO USA. [Lynfield, Ruth; Morin, Craig] Minnesota Dept Hlth, St Paul, MN USA. [Thomas, Ann] Oregon Publ Hlth Div, Portland, OR USA. [Meek, James] Connecticut Emerging Infect Program, New Haven, CT USA. [Farley, Monica M.] Emory Univ, Sch Med, Atlanta, GA USA. [Farley, Monica M.] Atlanta VA Med Ctr, Atlanta, GA USA. [Arnold, Kathryn E.] Georgia Emerging Infect Program, Atlanta, GA USA. [Reingold, Arthur] Calif Emerging Infect Program, Oakland, CA USA. [Craig, Allen S.] Tennessee Dept Hlth, Nashville, TN USA. [Craig, Allen S.; Schaffner, William] Vanderbilt Univ, Sch Med, Dept Prevent Med, Nashville, TN 37212 USA. [Bennett, Nancy M.] Univ Rochester, Sch Med & Dent, Rochester, NY 14627 USA. [Zansky, Shelley] New York State Dept Hlth, Albany, NY USA. [Baumbach, Joan] New Mexico Dept Hlth, Santa Fe, NM USA. [Lathrop, Sarah] Univ New Mexico, Albuquerque, NM 87131 USA. RP Dharan, NJ (reprint author), Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Med, 185 South Orange Ave,MSB 1-689, Newark, NJ 07103 USA. EM Dharannj@njms.rutgers.edu OI Shay, David/0000-0001-9619-4820 FU Centers for Disease Control and Prevention FX The EIP is a collaboration of state health departments, academic institutions and local partners and is funded by the Centers for Disease Control and Prevention. Members of the EIP sites were involved in the design and conduct of the study; collection, management, analysis and interpretation of the data and preparation, review or approval of the manuscript. NR 33 TC 6 Z9 6 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0891-3668 EI 1532-0987 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD JUN PY 2014 VL 33 IS 6 BP E141 EP E150 DI 10.1097/INF.0000000000000283 PG 10 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA AJ0OL UT WOS:000337354400002 PM 24642518 ER PT J AU Richards, TB White, MC Caraballo, RS AF Richards, Thomas B. White, Mary C. Caraballo, Ralph S. TI Lung Cancer Screening with Low-Dose Computed Tomography for Primary Care Providers SO PRIMARY CARE LA English DT Article DE Lung neoplasms; Screening; Computed tomography; Primary health care; Practice guidelines; Smoking cessation; Shared decision making ID CLINICAL-PRACTICE GUIDELINES; ED AMERICAN-COLLEGE; 1-YEAR FOLLOW-UP; UNITED-STATES; SMOKING-CESSATION; PULMONARY NODULES; DECISION-MAKING; TRIAL PARTICIPANTS; FLEISCHNER-SOCIETY; PROSPECTIVE COHORT AB This review provides an update on lung cancer screening with low-dose computed tomography (LDCT) and its implications for primary care providers. One of the unique features of lung cancer screening is the potential complexity in patient management if an LDCT scan reveals a small pulmonary nodule. Additional tests, consultation with multiple specialists, and follow-up evaluations may be needed to evaluate whether lung cancer is present. Primary care providers should know the resources available in their communities for lung cancer screening with LDCT and smoking cessation, and the key points to be addressed in informed and shared decision-making discussions with patients. C1 [Richards, Thomas B.; White, Mary C.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Caraballo, Ralph S.] Ctr Dis Control & Prevent, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Richards, TB (reprint author), Ctr Dis Control & Prevent, Epidemiol & Appl Res Branch, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Bldg 107,F-76,4770 Buford Highway Northeast, Atlanta, GA 30341 USA. EM TRichards@cdc.gov RI White, Mary /C-9242-2012 OI White, Mary /0000-0002-9826-3962 FU Intramural CDC HHS [CC999999] NR 121 TC 4 Z9 4 U1 0 U2 9 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0095-4543 EI 1558-299X J9 PRIMARY CARE JI Primary Care PD JUN PY 2014 VL 41 IS 2 BP 307 EP + DI 10.1016/j.pop.2014.02.007 PG 26 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA AJ0HC UT WOS:000337330100009 PM 24830610 ER PT J AU Wilson, JR Tzeng, WP Spesock, A Music, N Guo, Z Barrington, R Stevens, J Donis, RO Katz, JM York, IA AF Wilson, Jason R. Tzeng, Wen-Pin Spesock, April Music, Nedzad Guo, Zhu Barrington, Robert Stevens, James Donis, Ruben O. Katz, Jacqueline M. York, Ian A. TI Diversity of the murine antibody response targeting influenza A(H1N1pdm09) hemagglutinin SO VIROLOGY LA English DT Article DE Influenza; Antibody; Germline; Repertoire; Affinity; Cloning ID DEPENDENT CELLULAR CYTOTOXICITY; VIRUS A/PR/8/34 HEMAGGLUTININ; HUMAN MONOCLONAL-ANTIBODIES; SPECIES RICHNESS ESTIMATION; CAPTURE PROBABILITIES VARY; RECEPTOR-BINDING; A VIRUSES; NEUTRALIZING EPITOPE; ANTIGENIC VARIATION; MAXIMUM-LIKELIHOOD AB We infected mice with the 2009 influenza A pandemic virus (H1N1pdm09), boosted with an inactivated vaccine, and cloned immunoglobulins (Igs) from HA-specific B cells. Based on the redundancy in germline gene utilization, we inferred that between 72-130 unique IgH VDJ and 35 different IgL VJ combinations comprised the anti-HA recall response. The IgH VH1 and IgL VK14 variable gene families were employed most frequently. A representative panel of antibodies were cloned and expressed to confirm reactivity with H1N1pdm09 HA. The majority of the recombinant antibodies were of high avidity and capable of inhibiting H1N1pdm09 hemagglutination. Three of these antibodies were subtype-specific cross-reactive, binding to the HA of A/South Carolina/1/1918(H1N1), and one further reacted with A/swine/Iowa/15/1930(H1N1). These results help to define the genetic diversity of the influenza anti-HA antibody repertoire profile induced following infection and vaccination, which may facilitate the development of influenza vaccines that are more protective and broadly neutralizing. Importance: Protection against influenza viruses is mediated mainly by antibodies, and in most cases this antibody response is narrow, only providing protection against closely related viruses. In spite of this limited range of protection, recent findings indicate that individuals immune to one influenza virus may contain antibodies (generally a minority of the overall response) that are more broadly reactive. These findings have raised the possibility that influenza vaccines could induce a more broadly protective response, reducing the need for frequent vaccine strain changes. However, interpretation of these observations is hampered by the lack of quantitative characterization of the antibody repertoire. In this study, we used single-cell cloning of influenza HA-specific B cells to assess the diversity and nature of the antibody response to influenza hemagglutinin in mice. Our findings help to put bounds on the diversity of the anti-hemagglutinin antibody response, as well as characterizing the cross-reactivity, affinity, and molecular nature of the antibody response. (C) 2014 Elsevier Inc. All rights reserved. C1 [Wilson, Jason R.; Tzeng, Wen-Pin; Spesock, April; Music, Nedzad; Guo, Zhu; Stevens, James; Donis, Ruben O.; Katz, Jacqueline M.; York, Ian A.] Natl Ctr Immunizat & Resp Dis, Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. [Barrington, Robert] Univ S Alabama, Mobile, AL 36688 USA. RP York, IA (reprint author), Influenza Div, MS G-16,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM ite1@cdc.gov OI York, Ian/0000-0002-3478-3344 FU Oak Ridge Institute for Science and Education, Oak Ridge, TN; Centers for Disease Control and Prevention (CDC) FX This work was supported by the Centers for Disease Control and Prevention (CDC). J.R.W. received financial support for this work from the Oak Ridge Institute for Science and Education, Oak Ridge, TN. NR 55 TC 2 Z9 2 U1 1 U2 8 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD JUN PY 2014 VL 458 BP 114 EP 124 DI 10.1016/j.virol.2014.04.011 PG 11 WC Virology SC Virology GA AJ4RZ UT WOS:000337664800012 PM 24928044 ER PT J AU Yangco, BG Buchacz, K Baker, R Palella, FJ Armon, C Brooks, JT AF Yangco, Bienvenido G. Buchacz, Kate Baker, Rose Palella, Frank J. Armon, Carl Brooks, John T. CA HIV Outpatient Study Investigators TI Is Primary Mycobacterium avium Complex Prophylaxis Necessary in Patients with CD4 < 50 Cells/mu L Who Are Virologically Suppressed on cART? SO AIDS PATIENT CARE AND STDS LA English DT Article ID OPPORTUNISTIC ILLNESSES; ANTIRETROVIRAL THERAPY; INFECTION; COHORT; AIDS AB We analyzed 369 patients with no prior Mycobacterium avium complex (MAC) infection and CD4 < 50 cells/mu L (baseline), while on combination antiretroviral therapy(cART), for incidence rates of primary MAC infection during the 6 months after baseline, by prophylaxis status. Of participants (median age, 40 years old), most were male (81%) and about half were non-white; at baseline, 81% of participants were on cART > 60 days and 19% had HIV RNA < 1000 copies/mL, whereas 65% had HIV RNA > 10,000 copies/mL. Eleven patients had MAC infection within 6 months baseline (rate = 0.6/100 person months): 4/175 on MAC prophylaxis vs. 7/194, no MAC prophylaxis (p = 0.64). Of the 11 patients, seven had HIV RNA > 10,000, and three > 1000-9999 copies/mL at baseline (one missing). Median time to MAC infection was 62 days (IQR 43-126, maximum 139 days). No MAC infection occurred among 71 (19%) patients virologically suppressed (HIV RNA < 1000 copies/mL) at baseline, including 41 patients with no MAC prophylaxis during follow-up. A small number of eligible virologically suppressed participants and the lack of data on cART/MAC prophylaxis adherence limited our observational nonrandomized study. Primary MAC prophylaxis may not be required for cART-virologically suppressed patients with CD4 < 50 cells/mL. C1 [Yangco, Bienvenido G.] Infect Dis Res Inst Inc, Tampa, FL 33614 USA. [Buchacz, Kate; Brooks, John T.] Ctr Dis Control & Prevent CDC, Atlanta, GA USA. [Baker, Rose; Armon, Carl] Cerner Corp, Vienna, Austria. [Palella, Frank J.] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA. RP Yangco, BG (reprint author), Infect Dis Res Inst Inc, 4620 N Habana Ave Suite 203, Tampa, FL 33614 USA. EM bgy@yangcomd.com FU Centers for Disease Control and Prevention [200-2001-00133, 200-2006-18797, 200-2011-41872] FX This work was supported by the Centers for Disease Control and Prevention (contract Nos. 200-2001-00133, 200-2006-18797 and 200-2011-41872) NR 15 TC 2 Z9 2 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1087-2914 EI 1557-7449 J9 AIDS PATIENT CARE ST JI Aids Patient Care STDS PD JUN PY 2014 VL 28 IS 6 BP 280 EP 283 DI 10.1089/apc.2013.0270 PG 4 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AI9CG UT WOS:000337224700002 PM 24833016 ER PT J AU Davis, JC Verhagen, E Bryan, S Liu-Ambrose, T Borland, J Buchner, D Hendriks, MRC Weiler, R Morrow, JR van Mechelen, W Blair, SN Pratt, M Windt, J al-Tunaiji, H Macri, E Khan, KM AF Davis, Jennifer C. Verhagen, Evert Bryan, Stirling Liu-Ambrose, Teresa Borland, Jeff Buchner, David Hendriks, Marike R. C. Weiler, Richard Morrow, James R., Jr. van Mechelen, Willem Blair, Steven N. Pratt, Mike Windt, Johann al-Tunaiji, Hashel Macri, Erin Khan, Karim M. CA EPIC Grp TI 2014 Consensus Statement from the first Economics of Physical Inactivity Consensus (EPIC) Conference (Vancouver) SO BRITISH JOURNAL OF SPORTS MEDICINE LA English DT Article ID COST-EFFECTIVENESS; CARDIOVASCULAR-DISEASE; ACTIVITY INTERVENTIONS; LIFE-STYLE; PREVENTION; NUTRITION; OBESITY; PROMOTION; PROGRAMS; NEGLECT AB This article describes major topics discussed from the 'Economics of Physical Inactivity Consensus Workshop' (EPIC), held in Vancouver, Canada, in April 2011. Specifically, we (1) detail existing evidence on effective physical inactivity prevention strategies; (2) introduce economic evaluation and its role in health policy decisions; (3) discuss key challenges in establishing and building health economic evaluation evidence (including accurate and reliable costs and clinical outcome measurement) and (4) provide insight into interpretation of economic evaluations in this critically important field. We found that most methodological challenges are related to (1) accurately and objectively valuing outcomes; (2) determining meaningful clinically important differences in objective measures of physical inactivity; (3) estimating investment and disinvestment costs and (4) addressing barriers to implementation. We propose that guidelines specific for economic evaluations of physical inactivity intervention studies are developed to ensure that related costs and effects are robustly, consistently and accurately measured. This will also facilitate comparisons among future economic evidence. C1 [Davis, Jennifer C.] Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC V5Z 1M9, Canada. [Davis, Jennifer C.; Bryan, Stirling] Univ British Columbia, Ctr Clin Epidemiol & Evaluat, Vancouver, BC V5Z 1M9, Canada. [Verhagen, Evert; Hendriks, Marike R. C.; van Mechelen, Willem] Vrije Univ Amsterdam Med Ctr, Dept Publ & Occupat Hlth, Amsterdam, Netherlands. [Verhagen, Evert; Hendriks, Marike R. C.; van Mechelen, Willem] Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands. [Liu-Ambrose, Teresa; al-Tunaiji, Hashel; Macri, Erin] Univ British Columbia, Dept Phys Therapy, Ctr Hip Hlth, Vancouver, BC V5Z 1M9, Canada. [Borland, Jeff] Univ Melbourne, Melbourne, Vic 3010, Australia. [Buchner, David] MC 588 Univ Illinois, Dept Kinesiol & Community Hlth, Urbana, IL USA. [Hendriks, Marike R. C.] Maastricht Univ, Sch Nutr Toxicol & Metab, NUTRIM, Dept Human Movement Sci, NL-6200 MD Maastricht, Netherlands. [Weiler, Richard] Univ Coll London Hosp NHS Fdn Trust, Inst Sport Exercise & Hlth, London, England. [Morrow, James R., Jr.] Univ N Texas, Denton, TX 76203 USA. [Blair, Steven N.] Univ S Carolina, Dept Exercise Sci, Columbia, SC 29208 USA. [Pratt, Mike] Ctr Dis Control & Prevent, NCCDPHP, Atlanta, GA USA. [Windt, Johann] Univ British Columbia, Dept Expt Med, Abbotsford, BC, Canada. [Khan, Karim M.] Univ British Columbia, Dept Family Practice, Vancouver, BC V5Z 1M9, Canada. [Khan, Karim M.] Aspetar Orthopaed & Sports Med Hosp, Doha, Qatar. RP Davis, JC (reprint author), Univ British Columbia, Dept Hlth Care & Epidemiol, 828 West 10th Ave, Vancouver, BC V5Z 1M9, Canada. EM jennifer.davis@ubc.ca RI Verhagen, Evert/A-1502-2013 OI Verhagen, Evert/0000-0001-9227-8234 FU Canadian Institutes of Health Research-Mobility in Aging/CHHM Team in Vulnerable Seniors, BMJ Group, CHHM Walk the Talk Team; Canadian Institutes of Health Research (CIHR) [MAT-92025] FX The Economics of Physical Inactivity Consensus (EPIC) Symposium was funded by the Canadian Institutes of Health Research-Mobility in Aging/CHHM Team in Vulnerable Seniors, BMJ Group, CHHM Walk the Talk Team. Canadian Institutes of Health Research (CIHR)-Emerging Team Grant in Mobility in Aging MAT-92025. NR 42 TC 15 Z9 16 U1 2 U2 14 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0306-3674 EI 1473-0480 J9 BRIT J SPORT MED JI Br. J. Sports Med. PD JUN PY 2014 VL 48 IS 12 BP 947 EP + DI 10.1136/bjsports-2014-093575 PG 6 WC Sport Sciences SC Sport Sciences GA AJ0GV UT WOS:000337329300006 PM 24859181 ER PT J AU Majowicz, SE Scallan, E Jones-Bitton, A Sargeant, JM Stapleton, J Angulo, FJ Yeung, DH Kirk, MD AF Majowicz, Shannon E. Scallan, Elaine Jones-Bitton, Andria Sargeant, Jan M. Stapleton, Jackie Angulo, Frederick J. Yeung, Derrick H. Kirk, Martyn D. TI Global Incidence of Human Shiga Toxin-Producing Escherichia coli Infections and Deaths: A Systematic Review and Knowledge Synthesis SO FOODBORNE PATHOGENS AND DISEASE LA English DT Article ID UNITED-STATES; CHILDHOOD DIARRHEA; VTEC INFECTION; RISK-FACTORS; BURDEN; POPULATION; GASTROENTERITIS; SURVEILLANCE; PATHOGENS; BACTERIAL AB Objectives: Shiga toxin-producing Escherichia coli (STEC) are an important cause of foodborne disease, yet global estimates of disease burden do not exist. Our objective was to estimate the global annual number of illnesses due to pathogenic STEC, and resultant hemolytic uremic syndrome (HUS), end-stage renal disease (ESRD), and death. Materials: We searched Medline, Scopus, SIGLE/OpenGrey, and CABI and World Health Organization (WHO) databases for studies of STEC incidence in the general population, published between January 1, 1990 and April 30, 2012, in all languages. We searched health institution websites for notifiable disease data and reports, cross-referenced citations, and consulted international knowledge experts. We employed an a priori hierarchical study selection process and synthesized results using a stochastic simulation model to account for uncertainty inherent in the data. Results: We identified 16 articles and databases from 21 countries, from 10 of the 14 WHO Sub-Regions. We estimated that STEC causes 2,801,000 acute illnesses annually (95% Credible Interval [Cr. I.]: 1,710,000; 5,227,000), and leads to 3890 cases of HUS (95% Cr. I.: 2400; 6700), 270 cases of ESRD (95% Cr. I.: 20; 800), and 230 deaths (95% Cr. I.: 130; 420). Sensitivity analyses indicated these estimates are likely conservative. Conclusions: These are the first estimates of the global incidence of STEC-related illnesses, which have not been explicitly included in previous global burden of disease estimations. Compared to other pathogens with a foodborne transmission component, STEC appears to cause more cases than alveolar echinococcosis each year, but less than typhoid fever, foodborne trematodes, and nontyphoidal salmonellosis. Applications: Given the persistence of STEC globally, efforts aimed at reducing the burden of foodborne disease should consider the relative contribution of STEC in the target population. C1 [Majowicz, Shannon E.; Yeung, Derrick H.] Univ Waterloo, Sch Publ Hlth & Hlth Syst, Waterloo, ON N2L 3G1, Canada. [Scallan, Elaine] Univ Colorado Denver, Colorado Sch Publ Hlth, Aurora, CO USA. [Jones-Bitton, Andria; Sargeant, Jan M.] Univ Guelph, Dept Populat Med, Guelph, ON N1G 2W1, Canada. [Jones-Bitton, Andria; Sargeant, Jan M.] Univ Guelph, Ctr Publ Hlth & Zoonoses, Guelph, ON N1G 2W1, Canada. [Stapleton, Jackie] Univ Waterloo Lib, Waterloo, ON, Canada. [Angulo, Frederick J.] Ctr Dis Control & Prevent, Div Global Hlth Protect, Ctr Global Hlth, Atlanta, GA USA. [Kirk, Martyn D.] Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth, Acton, ACT, Australia. RP Majowicz, SE (reprint author), Univ Waterloo, Sch Publ Hlth & Hlth Syst, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada. EM smajowicz@uwaterloo.ca FU School of Public Health and Health Systems; World Health Organization's Foodborne Diseases Epidemiology Reference Group (FERG); Faculty of Applied Health Sciences (University of Waterloo) FX The authors thank Janet Harris (Public Health Agency of Canada) for assistance creating the search strings and conducting the review and extraction. The School of Public Health and Health Systems and the Faculty of Applied Health Sciences (University of Waterloo) and the World Health Organization's Foodborne Diseases Epidemiology Reference Group (FERG) supported this work. FERG was consulted during study design, assisted with obtaining identified references, provided feedback on preliminary results, and had the opportunity to comment on the final manuscript. NR 49 TC 28 Z9 28 U1 4 U2 30 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1535-3141 EI 1556-7125 J9 FOODBORNE PATHOG DIS JI Foodborne Pathog. Dis. PD JUN PY 2014 VL 11 IS 6 BP 447 EP 455 DI 10.1089/fpd.2013.1704 PG 9 WC Food Science & Technology SC Food Science & Technology GA AI8OA UT WOS:000337177400005 PM 24750096 ER PT J AU Dubey, JP Jones, JL AF Dubey, Jitender P. Jones, Jeffrey L. TI Comments on "Detection of Toxoplasma gondii in Raw Caprine, Ovine, Buffalo, Bovine, and Camel Milk Using Cell Cultivation, Cat Bioassay, Capture ELISA, and PCR Methods in Iran'' SO FOODBORNE PATHOGENS AND DISEASE LA English DT Letter ID UNITED-STATES; INFECTION; GOATS C1 [Dubey, Jitender P.] ARS, Beltsville Agr Res Ctr, Anim Parasit Dis Lab, USDA, Beltsville, MD 20705 USA. [Jones, Jeffrey L.] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA USA. RP Dubey, JP (reprint author), ARS, Beltsville Agr Res Ctr, Anim Parasit Dis Lab, USDA, Bldg 1001, Beltsville, MD 20705 USA. EM jitender.dubey@ars.usda.gov NR 11 TC 5 Z9 5 U1 0 U2 12 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1535-3141 EI 1556-7125 J9 FOODBORNE PATHOG DIS JI Foodborne Pathog. Dis. PD JUN PY 2014 VL 11 IS 6 BP 500 EP 501 DI 10.1089/fpd.2014.1786 PG 2 WC Food Science & Technology SC Food Science & Technology GA AI8OA UT WOS:000337177400013 PM 24886069 ER PT J AU Koziel, J Bryzek, D Sroka, A Maresz, K Glowczyk, I Bielecka, E Kantyka, T Pyrc, K Svoboda, P Pohl, J Potempa, J AF Koziel, Joanna Bryzek, Danuta Sroka, Aneta Maresz, Katarzyna Glowczyk, Izabela Bielecka, Ewa Kantyka, Tomasz Pyrc, Krzysztof Svoboda, Pavel Pohl, Jan Potempa, Jan TI Citrullination Alters Immunomodulatory Function of LL-37 Essential for Prevention of Endotoxin-Induced Sepsis SO JOURNAL OF IMMUNOLOGY LA English DT Article ID ANTIMICROBIAL PEPTIDE LL-37; NEUTROPHIL EXTRACELLULAR TRAPS; PEPTIDYLARGININE DEIMINASE; CATHELICIDIN FAMILY; POSTTRANSLATIONAL MODIFICATION; TISSUE INFLAMMATION; HUMAN SKIN; ANTIBACTERIAL; EXPRESSION; CELLS AB Cathelicidin LL-37 plays an essential role in innate immunity by killing invading microorganisms and regulating the inflammatory response. These activities depend on the cationic character of the peptide, which is conferred by arginine and lysine residues. At inflammatory foci in vivo, LL-37 is exposed to peptidyl arginine deiminase (PAD), an enzyme released by inflammatory cells. Therefore, we hypothesized that PAD-mediated citrullination of the arginine residues within LL-37 will abrogate its immunomodulatory functions. We found that, when citrullinated, LL-37 was at least 40 times less efficient at neutralizing the proinflammatory activity of LPS due to a marked decrease in its affinity for endotoxin. Also, the ability of citrullinated LL-37 to quench macrophage responses to lipoteichoic acid and poly(I:C) signaling via TLR2 and TLR3, respectively, was significantly reduced. Furthermore, in stark contrast to native LL-37, the modified peptide completely lost the ability to prevent morbidity and mortality in a mouse model of D-galactosamine-sensitized endotoxin shock. In fact, administration of citrullinated LL-37 plus endotoxin actually exacerbated sepsis due to the inability of LL-37 to neutralize LPS and the subsequent enhancement of systemic inflammation due to increased serum levels of IL-6. Importantly, serum from septic mice showed increased PAD activity, which strongly correlated with the level of citrullination, indicating that PAD-driven protein modification occurs in vivo. Because LL-37 is a potential treatment for sepsis, its administration should be preceded by a careful analysis to ensure that the citrullinated peptide is not generated in treated patients. C1 [Koziel, Joanna; Bryzek, Danuta; Sroka, Aneta; Maresz, Katarzyna; Glowczyk, Izabela; Bielecka, Ewa; Kantyka, Tomasz; Pyrc, Krzysztof; Potempa, Jan] Jagiellonian Univ, Fac Biochem Biophys & Biotechnol, Dept Microbiol, PL-30387 Krakow, Poland. [Svoboda, Pavel; Pohl, Jan] Ctr Dis Control & Prevent, Div Sci Resources, Atlanta, GA 30333 USA. [Potempa, Jan] Univ Louisville, Sch Dent, Ctr Oral Hlth & System Dis, Louisville, KY 40202 USA. RP Koziel, J (reprint author), Jagiellonian Univ, Fac Biochem Biophys & Biotechnol, Dept Microbiol, Gronostajowa 7 St, PL-30387 Krakow, Poland. EM joanna.koziel@uj.edu.pl OI Pyrc, Krzysztof/0000-0002-3867-7688 FU European Community [FP7-HEALTH-2010261460, FP7-HEALTH-F3-2012-306029, FP7-PEOPLE-2011-ITN-290246]; National Institutes of Health [DE 022597]; National Science Center, Poland [UMO-2011/01/B/NZ6/00268, 2011/03/B/NZ6/00053]; Foundation for Polish Science TEAM Project [DPS/424-329/10]; Polish Ministry of Science and Higher Education [137/7.PR-EU/2011/2]; European Union [POIG. 02.01.00-12-064/08] FX This work was supported by European Community Grants FP7-HEALTH-2010261460 "Gums&Joints," FP7-HEALTH-F3-2012-306029 "TRIGGER," and FP7-PEOPLE-2011-ITN-290246 "RAPID"; National Institutes of Health Grant DE 022597; National Science Center, Poland Grants UMO-2011/01/B/NZ6/00268 and 2011/03/B/NZ6/00053 (to J. Potempa and J.K., respectively); Foundation for Polish Science TEAM Project DPS/424-329/10; and Polish Ministry of Science and Higher Education Grant 137/7.PR-EU/2011/2. The Faculty of Biochemistry, Biophysics, and Biotechnology of the Jagiellonian University is a beneficiary of structural funds from the European Union (POIG. 02.01.00-12-064/08). NR 40 TC 11 Z9 11 U1 1 U2 9 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD JUN 1 PY 2014 VL 192 IS 11 BP 5363 EP 5372 DI 10.4049/jimmunol.1303062 PG 10 WC Immunology SC Immunology GA AI8MT UT WOS:000337171800047 PM 24771854 ER PT J AU Eke, PI Page, RC Wei, L Thornton-Evans, G Genco, RJ AF Eke, Paul I. Page, Roy C. Wei, Liang Thornton-Evans, Gina Genco, Robert J. TI Re: Update of the Case Definitions for PopulationBased Surveillance of Periodontitis. Eke PI, Page RC, Wei L, Thornton-Evans G, Genco RJ. (J Periodontol 2012; 83: 1449-1454.) Response SO JOURNAL OF PERIODONTOLOGY LA English DT Letter C1 [Eke, Paul I.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Atlanta, GA 30333 USA. [Page, Roy C.] Univ Washington, Sch Med & Dent, Reg Clin Dent Res Ctr, Seattle, WA 98195 USA. [Wei, Liang; Thornton-Evans, Gina] Ctr Dis Control & Prevent, Div Oral Hlth, Atlanta, GA USA. [Genco, Robert J.] SUNY Buffalo, Sch Dent Med, Buffalo, NY 14260 USA. [Genco, Robert J.] SUNY Buffalo, Sch Med, Buffalo, NY 14260 USA. [Genco, Robert J.] SUNY Buffalo, Sch Biomed Sci, Buffalo, NY 14260 USA. RP Eke, PI (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, Atlanta, GA 30333 USA. NR 5 TC 0 Z9 0 U1 0 U2 2 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 USA SN 0022-3492 EI 1943-3670 J9 J PERIODONTOL JI J. Periodont. PD JUN PY 2014 VL 85 IS 6 BP 766 EP 767 DI 10.1902/jop.2014.130676 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA AI8HJ UT WOS:000337151800011 PM 24875013 ER PT J AU Simon, TR Ikeda, RM Smith, EP Reese, LE Rabiner, DL Miller, S Winn, DM Dodge, KA Asher, SR Horne, AM Orpinas, P Martin, R Quinn, WH Tolan, PH Gorman-Smith, D Henry, DB Gay, FN Schoeny, M Farrell, AD Meyer, AL Sullivan, TN Allison, KW AF Simon, Thomas R. Ikeda, Robin M. Smith, Emilie Phillips Reese, Le'Roy E. Rabiner, David L. Miller, Shari Winn, Donna-Marie Dodge, Kenneth A. Asher, Steven R. Horne, Arthur M. Orpinas, Pamela Martin, Roy Quinn, William H. Tolan, Patrick H. Gorman-Smith, Deborah Henry, David B. Gay, Franklin N. Schoeny, Michael Farrell, Albert D. Meyer, Aleta L. Sullivan, Terri N. Allison, Kevin W. CA Multisite Violence Prevention TI Targeting High-Risk, Socially Influential Middle School Students to Reduce Aggression: Universal Versus Selective Preventive Intervention Effects SO JOURNAL OF RESEARCH ON ADOLESCENCE LA English DT Article ID MULTISITE VIOLENCE PREVENTION; EARLY ADOLESCENTS; RANDOMIZED-TRIAL; PROBLEM-BEHAVIOR; CONDUCT PROBLEMS; PEER-GROUPS; PROGRAM; FAMILIES; CHILDHOOD; IMPACT AB Early adolescence may be an opportune time for violence prevention, particularly if shifts in risk patterns and the importance of peer influence are considered. An important question is whether to target high-risk students or the entire population. Thirty-seven schools were randomized to four conditions: universal classroom intervention; selective family intervention; combined interventions; or control to test effects on a high-risk sample (N=1,805) of sixth graders targeted due to elevated aggression and social influence. Intent-to-treat and dosage-weighted growth comparisons through two years of postintervention revealed selective intervention benefits for physical aggression, aggressive strategies, and targeted family characteristics. Universal and combined interventions affected valuing academic achievement. Implications for middle school prevention, particularly selective targeting of socially influential high-risk youth, are discussed. C1 [Simon, Thomas R.; Ikeda, Robin M.; Smith, Emilie Phillips; Reese, Le'Roy E.] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA. [Rabiner, David L.; Miller, Shari; Winn, Donna-Marie; Dodge, Kenneth A.; Asher, Steven R.] Duke Univ, Durham, NC 27706 USA. Univ Georgia, Athens, GA 30602 USA. [Horne, Arthur M.; Orpinas, Pamela; Martin, Roy; Quinn, William H.] Univ Illinois, Chicago, IL USA. [Tolan, Patrick H.; Gorman-Smith, Deborah; Henry, David B.; Gay, Franklin N.; Schoeny, Michael; Farrell, Albert D.; Meyer, Aleta L.; Sullivan, Terri N.; Allison, Kevin W.] Virginia Commonwealth Univ, Richmond, VA 23284 USA. RP Tolan, PH (reprint author), Univ Virginia, Youth Nex Ctr, POB 400281, Charlottesville, VA 22904 USA. EM pht6t@virginia.edu OI Tolan, Patrick/0000-0001-5669-8442 NR 62 TC 4 Z9 4 U1 5 U2 25 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1050-8392 EI 1532-7795 J9 J RES ADOLESCENCE JI J. Res. Adolesc. PD JUN PY 2014 VL 24 IS 2 SI SI BP 364 EP 382 DI 10.1111/jora.12067 PG 19 WC Family Studies; Psychology, Developmental SC Family Studies; Psychology GA AJ3MU UT WOS:000337571500013 ER PT J AU Cooper, CP Gelb, CA Chu, J AF Cooper, Crystale Purvis Gelb, Cynthia A. Chu, Jennifer TI What's the Appeal? Testing Public Service Advertisements to Raise Awareness About Gynecologic Cancer SO JOURNAL OF WOMENS HEALTH LA English DT Article AB In 2013, the Centers for Disease Control and Prevention's (CDC) Inside Knowledge: Get the Facts About Gynecologic Cancer campaign tested creative concepts for English-and Spanish-language video advertisements (for use on television and the Internet) with women aged 35-64 years. Sixteen English and nine Spanish focus groups were conducted in four U. S. cities. CDC used animatics (a series of photographs edited together with a sound track) to simulate produced advertisements, without having to incur the high cost of filming and production. Advertisement concepts consistently resonating with participants featured cancer survivors, were straightforward, included information about cancer symptoms, displayed Inside Knowledge educational materials, and featured diverse women. In the general population focus groups, a primacy testing order effect was observed in which the concept tested first tended to be the most favorably received. Varying the order in which concepts were tested and considering testing order when interpreting results was critical. C1 [Cooper, Crystale Purvis] Soltera Ctr Canc Prevent & Control, Tucson, AZ USA. [Gelb, Cynthia A.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Chu, Jennifer] Ogilvy Washington, Washington, DC USA. RP Gelb, CA (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, 4770 Buford Highway,Bldg 107,MS F76, Atlanta, GA 30341 USA. EM cgelb@cdc.gov FU Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention FX Funding for the research described here was provided by the Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. The authors thank Wendy Child and Jackeline Fernandez for their assistance with developing the focus group discussion guide and facilitating the groups. NR 4 TC 3 Z9 3 U1 0 U2 5 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 EI 1931-843X J9 J WOMENS HEALTH JI J. Womens Health PD JUN PY 2014 VL 23 IS 6 BP 488 EP 492 DI 10.1089/jwh.2014.4759 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA AI9BT UT WOS:000337222700003 PM 24707839 ER PT J AU Derosset, L Mullenix, A Flores, A Mattia-Dewey, D Mai, CT AF deRosset, Leslie Mullenix, Amy Flores, Alina Mattia-Dewey, Daniel Mai, Cara T. TI Promotora de Salud: Promoting Folic Acid Use Among Hispanic Women SO JOURNAL OF WOMENS HEALTH LA English DT Article ID UNITED-STATES; SPINA-BIFIDA; FORTIFICATION; INTERVENTION; DEFECTS AB Background: The U. S. Public Health Service recommends that all women in the United States capable of becoming pregnant consume 400 mu g of folic acid daily to reduce their risk of having a pregnancy affected by a neural tube defect (NTD). However, disparities exist in the consumption of folic acid, with Hispanic women having lower rates of folic acid consumption than non-Hispanic white women. Methods: A community-based feasibility study was designed to assess the utility of the promotora de salud model to promote consumption of multivitamins containing folic acid for the prevention of NTDs among Spanish-speaking Hispanic women in North Carolina. The study consisted of an educational intervention given by a promotora (a lay, community health worker), with data collection occurring at baseline and four months post-intervention to measure changes in knowledge and behavior. Overall, 52% (n = 303) of participants completed all components of the study. Results: Self-reported daily multivitamin consumption increased from 24% at baseline to 71% four months post-intervention. During the same time frame, awareness of folic acid increased from 78% to 98% and knowledge of the role of folic acid in the prevention of birth defects increased from 82% to 92%. Conclusions: The results of this study indicate that the promotora de salud model may be effective in reaching a subpopulation of women with the folic acid message. Additional studies with larger population sizes are warranted to validate these findings. C1 [deRosset, Leslie] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Maternal Child Hlth, Chapel Hill, NC 27599 USA. [deRosset, Leslie; Mullenix, Amy] March Dimes North Carolina Preconcept Hlth Campai, Raleigh, NC USA. [Flores, Alina; Mattia-Dewey, Daniel; Mai, Cara T.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. RP Derosset, L (reprint author), Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Maternal Child Hlth, 170 Roseanau Hall,CB 7400,135 Dauer Dr, Chapel Hill, NC 27599 USA. EM derosset@email.unc.edu FU National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention; North Carolina March of Dimes Chapter [200-2009-M-32674] FX Funding for the project was obtained from the National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention and the North Carolina March of Dimes Chapter (Contract No. 200-2009-M-32674). NR 24 TC 2 Z9 2 U1 0 U2 10 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 EI 1931-843X J9 J WOMENS HEALTH JI J. Womens Health PD JUN PY 2014 VL 23 IS 6 BP 525 EP 531 DI 10.1089/jwh.2013.4695 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA AI9BT UT WOS:000337222700009 PM 24707879 ER PT J AU Haley, DF Golin, C El-Sadr, W Hughes, JP Wang, J Isler, MR Mannheimer, S Kuo, I Lucas, J DiNenno, E Justman, J Frew, PM Emel, L Rompalo, A Polk, S Adimora, AA Rodriquez, L Soto-Torres, L Hodder, S AF Haley, Danielle F. Golin, Carol El-Sadr, Wafaa Hughes, James P. Wang, Jing Isler, Malika Roman Mannheimer, Sharon Kuo, Irene Lucas, Jonathan DiNenno, Elizabeth Justman, Jessica Frew, Paula M. Emel, Lynda Rompalo, Anne Polk, Sarah Adimora, Adaora A. Rodriquez, Lorenna Soto-Torres, Lydia Hodder, Sally CA HIV Prevention Trials Network HPTN TI Venue-Based Recruitment of Women at Elevated Risk for HIV: An HIV Prevention Trials Network Study SO JOURNAL OF WOMENS HEALTH LA English DT Article ID SEXUALLY-TRANSMITTED INFECTIONS; BEHAVIORAL SURVEILLANCE SYSTEM; VACCINE EFFICACY TRIALS; AFRICAN-AMERICAN WOMEN; UNITED-STATES; CLINICAL-TRIALS; INCARCERATION RATES; HEALTH DISPARITIES; SEX PARTNERS; US AB Background: The challenge of identifying and recruiting U. S. women at elevated risk for HIV acquisition impedes prevention studies and services. HIV Prevention Trials Network (HPTN) 064 was a U. S. multisite, longitudinal cohort study designed to estimate HIV incidence among women living in communities with prevalent HIV and poverty. Venue-based sampling (VBS) methodologies and participant and venue characteristics are described. Methods: Eligible women were recruited from 10 U. S. communities with prevalent HIV and poverty using VBS. Participant eligibility criteria included age 18-44 years, residing in a designated census tract/zip code, and self-report of at least one high-risk personal and/or male sexual partner characteristic associated with HIV acquisition (e. g., incarceration history). Ethnography was conducted to finalize recruitment areas and venues. Results: Eight thousand twenty-nine women were screened and 2,099 women were enrolled (88% black, median age 29 years) over 14 months. The majority of participants were recruited from outdoor venues (58%), retail spaces (18%), and social service organizations (13%). The proportion of women recruited per venue category varied by site. Most participants (73%) had both individual and partner characteristics that qualified them for the study; 14% were eligible based on partner risk only. Conclusion: VBS is a feasible and effective approach to rapidly recruit a population of women at enhanced risk for HIV in the United States. Such a recruitment approach is needed in order to engage women most at risk and requires strong community engagement. C1 [Haley, Danielle F.; Lucas, Jonathan] FHI 360, Durham, NC USA. [Haley, Danielle F.; Frew, Paula M.] Emory Univ, Dept Behav Sci & Hlth Educ, Rollins Sch Publ Hlth, Atlanta, GA 30033 USA. [Golin, Carol; Adimora, Adaora A.] Univ N Carolina, Sch Med, Chapel Hill, NC USA. [Golin, Carol; Adimora, Adaora A.] Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [El-Sadr, Wafaa; Justman, Jessica] Columbia Univ, Mailman Sch Publ Hlth, Int Ctr AIDS Care & Treatment Programs, New York, NY USA. [Hughes, James P.; Wang, Jing; Emel, Lynda] Fred Hutchinson Canc Res Ctr, Dept Biostat, Seattle, WA 98104 USA. [Hughes, James P.] Univ Washington, Div Infect Dis, Seattle, WA 98195 USA. [Isler, Malika Roman] Univ N Carolina, Sch Med, Dept Social Med, Chapel Hill, NC USA. [Isler, Malika Roman] Univ N Carolina, North Carolina Translat & Clin Sci Inst, Chapel Hill, NC USA. [Mannheimer, Sharon] Columbia Univ, Harlem Hosp Ctr, New York, NY USA. [Mannheimer, Sharon] Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA. [Kuo, Irene] George Washington Univ, Sch Publ Hlth & Hlth Serv, Washington, DC USA. [DiNenno, Elizabeth] Ctr Dis Control & Prevent, Atlanta, GA USA. [Frew, Paula M.] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA 30033 USA. [Rompalo, Anne; Polk, Sarah] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Rodriquez, Lorenna] Bronx Lebanon Hosp Ctr, New York, NY USA. [Soto-Torres, Lydia] NIAID, NIH, Bethesda, MD 20892 USA. [Hodder, Sally] Rutgers State Univ, New Jersey Med Sch, Newark, NJ 07102 USA. RP Haley, DF (reprint author), Emory Univ, Dept Behav Sci & Hlth Educ, 1518 Clifton Rd Northeast, Atlanta, GA 30033 USA. EM dfhaley@emory.edu OI Frew, Paula/0000-0002-3078-9124 FU National Institute of Allergy and Infectious Diseases, National Institute on Drug Abuse; National Institute of Mental Health [UM1 AI068619, U01-AI068613, UM1-AI068613]; Centers for Innovative Research to Control AIDS, Mailman School of Public Health, Columbia University [5U1Al069466]; University of North Carolina Clinical Trials Unit [AI069423]; University of North Carolina Clinical Trials Research Center of the Clinical and Translational Science Award [RR 025747]; University of North Carolina Center for AIDS Research [AI050410]; Emory University HIV/AIDS Clinical Trials Unit [5UO1AI069418]; Center for AIDS Research [P30 AI050409]; Clinical and Translational Science Award [UL1 RR025008]; Terry Beirn Community Programs for Clinical Research on AIDS Clinical Trials Unit [5 UM1 AI069503-07]; Johns Hopkins Adult AIDS Clinical Trial Unit [AI069465]; Johns Hopkins Clinical and Translational Science Award [UL1 RR 25005]; HPTN Scholars Program; National Institute of Allergy and Infectious Disease; National Institute of Mental Health; Emory University Laney Graduate School Robert W. Woodruff Pre-Doctoral Fellowship; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Centers for Disease Control and Prevention; HPTN FX Funding for this study provided through grants from the National Institute of Allergy and Infectious Diseases, National Institute on Drug Abuse, and National Institute of Mental Health (UM1 AI068619, U01-AI068613, and UM1-AI068613); Centers for Innovative Research to Control AIDS, Mailman School of Public Health, Columbia University (5U1Al069466); University of North Carolina Clinical Trials Unit (AI069423); University of North Carolina Clinical Trials Research Center of the Clinical and Translational Science Award (RR 025747); University of North Carolina Center for AIDS Research (AI050410); Emory University HIV/AIDS Clinical Trials Unit (5UO1AI069418), Center for AIDS Research (P30 AI050409), and Clinical and Translational Science Award (UL1 RR025008); The Terry Beirn Community Programs for Clinical Research on AIDS Clinical Trials Unit(5 UM1 AI069503-07); The Johns Hopkins Adult AIDS Clinical Trial Unit (AI069465); The Johns Hopkins Clinical and Translational Science Award (UL1 RR 25005); and the HPTN Scholars Program funded by the National Institute of Allergy and Infectious Disease and the National Institute of Mental Health. The primary author's time has been supported in part by the Emory University Laney Graduate School Robert W. Woodruff Pre-Doctoral Fellowship.; The views expressed herein are those of the authors and do not necessarily represent the views of the National Institute of Allergy and Infectious Diseases, the National Institute of Mental Health, the National Institutes of Health, the Centers for Disease Control and Prevention, the HPTN, or its funders. NR 58 TC 4 Z9 4 U1 1 U2 12 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 EI 1931-843X J9 J WOMENS HEALTH JI J. Womens Health PD JUN PY 2014 VL 23 IS 6 BP 541 EP 551 DI 10.1089/jwh.2013.4654 PG 11 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA AI9BT UT WOS:000337222700011 PM 24742266 ER PT J AU Daniels, RD Kubale, TL Yiin, JH Dahm, MM Hales, TR Baris, D Zahm, SH Beaumont, JJ Waters, KM Pinkerton, LE AF Daniels, Robert D. Kubale, Travis L. Yiin, James H. Dahm, Matthew M. Hales, Thomas R. Baris, Dalsu Zahm, Shelia H. Beaumont, James J. Waters, Kathleen M. Pinkerton, Lynne E. TI Mortality and cancer incidence in a pooled cohort of US firefighters from San Francisco, Chicago and Philadelphia (1950-2009) SO OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID FLORIDA PROFESSIONAL FIREFIGHTERS; HEALTH INTERVIEW SURVEY; CENTRAL UNITED-STATES; TABLE ANALYSIS SYSTEM; FIRE FIGHTERS; OCCUPATIONAL EXPOSURES; INCIDENCE RATES; ALCOHOL-USE; TOBACCO USE; OBESITY AB Objectives To examine mortality patterns and cancer incidence in a pooled cohort of 29 993 US career firefighters employed since 1950 and followed through 2009. Methods Mortality and cancer incidence were evaluated by life table methods with the US population referent. Standardised mortality (SMR) and incidence (SIR) ratios were determined for 92 causes of death and 41 cancer incidence groupings. Analyses focused on 15 outcomes of a priori interest. Sensitivity analyses were conducted to examine the potential for significant bias. Results Person-years at risk totalled 858 938 and 403 152 for mortality and incidence analyses, respectively. All-cause mortality was at expectation (SMR = 0.99, 95% CI 0.97 to 1.01, n = 12 028). There was excess cancer mortality (SMR = 1.14, 95% CI 1.10 to 1.18, n = 3285) and incidence (SIR = 1.09, 95% CI 1.06 to 1.12, n = 4461) comprised mainly of digestive (SMR = 1.26, 95% CI 1.18 to 1.34, n = 928; SIR = 1.17, 95% CI 1.10 to 1.25, n = 930) and respiratory (SMR= 1.10, 95% CI 1.04 to 1.17, n = 1096; SIR = 1.16, 95% CI 1.08 to 1.24, n = 813) cancers. Consistent with previous reports, modest elevations were observed in several solid cancers; however, evidence of excess lymphatic or haematopoietic cancers was lacking. This study is the first to report excess malignant mesothelioma (SMR= 2.00, 95% CI 1.03 to 3.49, n = 12; SIR = 2.29, 95% CI 1.60 to 3.19, n = 35) among US firefighters. Results appeared robust under differing assumptions and analytic techniques. Conclusions Our results provide evidence of a relation between firefighting and cancer. The new finding of excess malignant mesothelioma is noteworthy, given that asbestos exposure is a known hazard of firefighting. C1 [Daniels, Robert D.; Kubale, Travis L.; Yiin, James H.; Dahm, Matthew M.; Hales, Thomas R.; Waters, Kathleen M.; Pinkerton, Lynne E.] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH 45226 USA. [Baris, Dalsu; Zahm, Shelia H.] NCI, Div Canc Epidemiol & Genet, Gaithersburg, MD USA. [Beaumont, James J.] UC Davis Dept Publ Hlth Sci, Sacramento, CA USA. RP Daniels, RD (reprint author), NIOSH, Div Surveillance Hazard Evaluat & Field Studies, 4676 Columbia Pkwy,Mailstop R-13, Cincinnati, OH 45226 USA. EM rtd2@cdc.gov RI Zahm, Shelia/B-5025-2015 FU National Institute for Occupational Safety and Health (NIOSH) by National Occupational Research Agenda (NORA); US Fire Administration (USFA); National Institutes of Health (NIH), National Cancer Institute (NCI) FX Research funding was provided by the National Institute for Occupational Safety and Health (NIOSH) by intramural award under the National Occupational Research Agenda (NORA), and by the US Fire Administration (USFA). This research was also supported, in part, by the intramural research programme of the National Institutes of Health (NIH), National Cancer Institute (NCI). NR 45 TC 28 Z9 29 U1 2 U2 19 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1351-0711 EI 1470-7926 J9 OCCUP ENVIRON MED JI Occup. Environ. Med. PD JUN PY 2014 VL 71 IS 6 BP 388 EP 397 DI 10.1136/oemed-2013-101662 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AI9MV UT WOS:000337257600003 PM 24142974 ER PT J AU Yong, LC Luckhaupt, SE Li, J Calvert, GM AF Yong, Lee C. Luckhaupt, Sara E. Li, Jia Calvert, Geoffrey M. TI Quit interest, quit attempt and recent cigarette smoking cessation in the US working population, 2010 SO OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID HEALTH INTERVIEW SURVEY; UNITED-STATES; STOP SMOKING; WORKPLACE; PREDICTORS; BEHAVIORS; SMOKERS; IMPACT; ADULTS; PRODUCTIVITY AB Objectives To determine the prevalence of cigarette smoking cessation and examine the association between cessation and various factors among workers in a nationally representative sample of US adults. Methods Data were derived from the 2010 National Health Interview Survey. Prevalence rates were calculated for interest in quitting smoking, making an attempt to quit smoking, and successful smoking cessation (defined as smokers who had quit for 6-12 months). Logistic regression analyses were used to identify factors associated with cessation after adjustment for demographic characteristics (age group, race/ethnicity, educational level and marital status). Results Data were available for 17 524 adults who were employed in the 12 months prior to interview. The prevalence of quit interest, quit attempt and recent cessation was 65.2%, 53.8% and 6.8%, respectively. Quit interest was less likely among workers with long work hours, but more likely among workers with job insecurity, or frequent workplace skin and/or respiratory exposures. Quit attempt was more likely among workers with a hostile work environment but less likely among workers living in a home that permitted smoking or who smoked >= 11 cigarettes/day. Recent smoking cessation was less likely among workers with frequent exposure to others smoking at work or living in a home that permitted smoking, but more likely among workers with health insurance. Conclusions Factors associated with cessation interest or attempt differed from those associated with successful cessation. Cessation success might be improved by reducing exposure to others smoking at work and home, and by improving access to health insurance. C1 [Yong, Lee C.; Luckhaupt, Sara E.; Li, Jia; Calvert, Geoffrey M.] NIOSH, Surveillance Branch, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH 45226 USA. RP Yong, LC (reprint author), NIOSH, Surveillance Branch, Div Surveillance Hazard Evaluat & Field Studies, 4676 Columbia Pkwy,Mail Stop R-15, Cincinnati, OH 45226 USA. EM LAY7@cdc.gov FU Intramural CDC HHS [CC999999] NR 40 TC 7 Z9 7 U1 1 U2 4 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1351-0711 EI 1470-7926 J9 OCCUP ENVIRON MED JI Occup. Environ. Med. PD JUN PY 2014 VL 71 IS 6 BP 405 EP 414 DI 10.1136/oemed-2013-101852 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AI9MV UT WOS:000337257600005 PM 24497440 ER PT J AU Alshaarawy, O Zhu, MT Ducatman, AM Conway, B Andrew, ME AF Alshaarawy, Omayma Zhu, Motao Ducatman, Alan M. Conway, Baqiyyah Andrew, Michael E. TI Urinary polycyclic aromatic hydrocarbon biomarkers and diabetes mellitus SO OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID OXIDATIVE STRESS; EXPOSURE; RISK; INFLAMMATION; ASSOCIATION; EXCRETION; COTININE; SMOKING; MARKERS; WORKERS AB Objective The aim of the current study is to investigate the association of polycyclic aromatic hydrocarbons (PAHs), a group of environmental pollutants, with diabetes mellitus. Animal studies link PAHs to inflammation and subsequent development of diabetes mellitus. In addition, occupational studies suggest that exposure to other aromatic hydrocarbons such as dioxins may be associated with diabetes risk in humans. Design We examined participants from the merged National Health and Nutrition Examination Survey 2001-2002, 2003-2004 and 2005-2006. Exposures of interest were eight urinary monohydroxy-PAHs. Our outcome was diabetes mellitus defined as a glycohemoglobin level (HbA1c) >= 6.5%, a self-reported physician diagnosis of diabetes or use of oral hypoglycaemic medication or insulin. Analyses were adjusted for age, sex, body mass index, race, alcohol consumption, poverty-income ratio, total cholesterol and serum cotinine. Results We observed a positive association between urinary biomarkers of 1 and 2-hydroxynapthol, 2-hydroxyphenanthrene and summed low molecular weight (LMW) PAH biomarkers, and diabetes mellitus. Compared with participants with summed LMW PAH biomarkers in the lowest quartile, the multivariable-adjusted OR of diabetes mellitus among those in the highest quartile was 3.1 (95% CI 1.6 to 5.8). Conclusions Urinary biomarkers of 1 and 2-hydroxynapthol, 2-hydroxyphenanthrene and summed LMW PAH biomarkers are associated with diabetes mellitus in US adults 20-65 years of age. The association of a one-time biomarker of PAH exposure has limitations commonly associated with cross-sectional studies, yet is consistent with experimental animal data and is worthy of additional consideration. C1 [Alshaarawy, Omayma] Michigan State Univ, Dept Epidemiol & Biostat, Sch Med, E Lansing, MI 48824 USA. [Zhu, Motao; Conway, Baqiyyah] W Virginia Univ, Dept Epidemiol, Sch Publ Hlth, Morgantown, WV 26506 USA. [Ducatman, Alan M.] W Virginia Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Morgantown, WV 26506 USA. [Andrew, Michael E.] NIOSH, Biostat & Epidemiol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV USA. RP Alshaarawy, O (reprint author), Michigan State Univ, Dept Epidemiol & Biostat, E Lansing, MI 48824 USA. EM oalshaarawy@epi.msu.edu RI Tuomisto, Jouko/J-7450-2012 FU Intramural CDC HHS [CC999999] NR 32 TC 12 Z9 12 U1 1 U2 11 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1351-0711 EI 1470-7926 J9 OCCUP ENVIRON MED JI Occup. Environ. Med. PD JUN PY 2014 VL 71 IS 6 BP 437 EP 441 DI 10.1136/oemed-2013-101987 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AI9MV UT WOS:000337257600009 PM 24638887 ER PT J AU Boyle, CA Bocchini, JA Kelly, J AF Boyle, Coleen A. Bocchini, Joseph A., Jr. Kelly, James TI Reflections on 50 Years of Newborn Screening SO PEDIATRICS LA English DT Editorial Material DE newborn screening ID HERITABLE DISORDERS; ADVISORY-COMMITTEE; STATEMENT; SECRETARY; CHILDREN; HEALTH C1 [Boyle, Coleen A.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Bocchini, Joseph A., Jr.] Louisiana State Univ, Hlth Sci Ctr, Dept Pediat, Shreveport, LA 71105 USA. [Kelly, James] Hunters Hope Fdn, Orchard Pk, NY USA. RP Boyle, CA (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM cboyle@cdc.gov FU Intramural CDC HHS [CC999999] NR 7 TC 6 Z9 6 U1 1 U2 3 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD JUN PY 2014 VL 133 IS 6 BP 961 EP 963 DI 10.1542/peds.2013-3658 PG 3 WC Pediatrics SC Pediatrics GA AI8MY UT WOS:000337172600043 PM 24843062 ER PT J AU Quinlan, K Shults, RA Rudd, RA AF Quinlan, Kyran Shults, Ruth A. Rudd, Rose A. TI Child Passenger Deaths Involving Alcohol-Impaired Drivers SO PEDIATRICS LA English DT Article DE motor vehicle accidents; accident prevention; child passenger safety; epidemiology-injury; injury prevention and control ID INTERVENTIONS; POLICY AB BACKGROUND AND OBJECTIVE: Approximately 1 in 5 child passenger deaths in the United States involves an alcohol-impaired driver, most commonly the child's own driver. The objective of this study was to document recent trends and state-specific rates of these deaths. METHODS: A descriptive analysis of 2001-2010 Fatality Analysis Reporting System data for child passengers aged <15 years killed in alcohol-impaired driving crashes. Driver impairment was defined as a blood alcohol concentration of >= 0.08 g/dL. RESULTS: During 2001-2010, 2344 children <15 years were killed in crashes involving at least 1 alcohol-impaired driver. Of these children, 1515 (65%) were riding with an impaired driver. Annual deaths among children riding with an alcohol-impaired driver decreased by 41% over the decade. Among the 37 states included in the state-level analysis, Texas (272) and California (135) had the most children killed while riding with an impaired driver and South Dakota (0.98) and New Mexico (0.86) had the highest annualized child passenger death rates (per 100 000 children). Most (61%) child passengers of impaired drivers were unrestrained at the time of the crash. One-third of the impaired drivers did not have a valid driver's license. CONCLUSIONS: Alcohol-impaired driving remains a substantial threat to the safety of child passengers in the United States, and typically involves children being driven by impaired drivers. This risk varies meaningfully among states. To make further progress, states and communities could consider increased use of effective interventions and efforts aimed specifically at protecting child passengers from impaired drivers. C1 [Quinlan, Kyran] Northwestern Univ, Dept Pediat, Feinberg Sch Med, Div Community Based Primary Care, Chicago, IL 60611 USA. [Quinlan, Kyran] Erie Family Hlth Ctr, Chicago, IL 60622 USA. [Shults, Ruth A.; Rudd, Rose A.] Ctr Dis Control & Prevent, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA. RP Quinlan, K (reprint author), Erie Family Hlth Ctr, 1701 W Super St, Chicago, IL 60622 USA. EM kquinlan@eriefamilyhealth.org NR 21 TC 7 Z9 7 U1 0 U2 1 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD JUN PY 2014 VL 133 IS 6 BP 966 EP 972 DI 10.1542/peds.2013-2318 PG 7 WC Pediatrics SC Pediatrics GA AI8MY UT WOS:000337172600045 PM 24799550 ER PT J AU Hambidge, SJ Newcomer, SR Narwaney, KJ Glanz, JM Daley, MF Xu, S Shoup, A Rowhani-Rahbar, A Klein, NP Lee, GM Nelson, JC Lugg, M Naleway, AL Nordin, JD Weintraub, E DeStefano, F AF Hambidge, Simon J. Newcomer, Sophia R. Narwaney, Komal J. Glanz, Jason M. Daley, Matthew F. Xu, Stan Shoup, Ann Rowhani-Rahbar, Ali Klein, Nicola P. Lee, Grace M. Nelson, Jennifer C. Lugg, Marlene Naleway, Allison L. Nordin, James D. Weintraub, Eric DeStefano, Frank TI Timely Versus Delayed Early Childhood Vaccination and Seizures SO PEDIATRICS LA English DT Article DE vaccine safety; immunization; vaccine; seizures; vaccine delay ID INFLUENZAE TYPE-B; ACELLULAR PERTUSSIS; FEBRILE SEIZURES; INACTIVATED POLIOVIRUS; IMMUNIZATION SAFETY; PARENTAL REFUSAL; YOUNG-CHILDREN; UNITED-STATES; RISK; VACCINES AB BACKGROUND: Little is known regarding the timing of childhood vaccination and postvaccination seizures. METHODS: In a cohort of 323 247 US children from the Vaccine Safety Datalink born from 2004 to 2008, we analyzed the association between the timing of childhood vaccination and the first occurrence of seizure with a self-controlled case series analysis of the first doses of individual vaccines received in the first 2 years of life. RESULTS: In infants, there was no association between the timing of infant vaccination and postvaccination seizures. In the second year of life, the incident rate ratio (IRR) for seizures after receipt of the first measles-mumps-rubella vaccine (MMR) dose at 12 to 15 months was 2.65 (95% confidence interval [CI] 1.99-3.55); the IRR after an MMR dose at 16 to 23 months was 6.53 (95% CI 3.15-13.53). The IRR for seizures after receipt of the first measles-mumps-rubella-varicella vaccine (MMRV) dose at 12 to 15 months was 4.95 (95% CI 3.68-6.66); the IRR after an MMRV dose at 16 to 23 months was 9.80 (95% CI 4.35-22.06). CONCLUSIONS: There is no increased risk of postvaccination seizure in infants regardless of timing of vaccination. In year 2, delaying MMR vaccine past 15 months of age results in a higher risk of seizures. The strength of the association is doubled with MMRV vaccine. These findings suggest that on-time vaccination is as safe with regard to seizures as delayed vaccination in the first year of life, and that delayed vaccination in the second year of life is associated with more postvaccination seizures than on-time vaccination. C1 [Hambidge, Simon J.; Newcomer, Sophia R.; Narwaney, Komal J.; Glanz, Jason M.; Daley, Matthew F.; Xu, Stan; Shoup, Ann] Kaiser Permanente Colorado, Inst Hlth Res, Denver, CO USA. [Hambidge, Simon J.] Denver Hlth, Dept Community Hlth Serv, Denver, CO USA. [Hambidge, Simon J.; Daley, Matthew F.] Univ Colorado, Sch Med, Dept Pediat, Aurora, CO USA. [Hambidge, Simon J.; Glanz, Jason M.] Univ Colorado, Sch Publ Hlth, Dept Epidemiol, Aurora, CO USA. [Rowhani-Rahbar, Ali] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA. [Klein, Nicola P.] Kaiser Permanente Vaccine Study Ctr, Oakland, CA USA. [Lee, Grace M.] Harvard Pilgrim Hlth Care Inst, Dept Populat Med, Boston, MA USA. [Lee, Grace M.] Harvard Univ, Sch Med, Boston, MA USA. [Lee, Grace M.] Boston Childrens Hosp, Div Infect Dis, Boston, MA USA. [Lee, Grace M.] Boston Childrens Hosp, Dept Lab Med, Boston, MA USA. [Nelson, Jennifer C.] Grp Hlth Res Inst, Seattle, WA USA. [Lugg, Marlene] Kaiser Permanente So Calif, Dept Res & Evaluat, Pasadena, CA 91101 USA. [Naleway, Allison L.] Kaiser Fdn Hosp Ctr Hlth Res, Portland, OR USA. [Nordin, James D.] Hlth Partners Res Fdn, Minneapolis, MN USA. [Weintraub, Eric; DeStefano, Frank] Ctr Dis Control & Prevent, Immunizat Safety Off, Div Healthcare Qual Promot, Atlanta, GA USA. RP Hambidge, SJ (reprint author), Denver Hlth Mailcode 1914,660 Bannock St, Denver, CO 80204 USA. EM simon.hambidge@dhha.org OI Naleway, Allison/0000-0001-5747-4643 FU Vaccine Safety Surveillance and Assessment Project [200-2002-00732]; American's Health Insurance Plans - Centers for Disease Control and Prevention FX This study was supported through the Vaccine Safety Surveillance and Assessment Projects (contract 200-2002-00732) with American's Health Insurance Plans, funded by the Centers for Disease Control and Prevention. The Centers for Disease Control and Prevention coauthors (Mr Weintraub and Dr DeStefano) were involved in the design and conduct of the study; analysis and interpretation of the data; and review and approval of the manuscript. NR 41 TC 13 Z9 13 U1 1 U2 10 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD JUN PY 2014 VL 133 IS 6 BP E1492 EP E1499 DI 10.1542/peds.2013-3429 PG 8 WC Pediatrics SC Pediatrics GA AI8MY UT WOS:000337172600002 PM 24843064 ER PT J AU Middleman, AB Baker, CJ Kozinetz, CA Kamili, S Nguyen, C Hu, DJ Spradling, PR AF Middleman, Amy B. Baker, Carol J. Kozinetz, Claudia A. Kamili, Saleem Chi Nguyen Hu, Dale J. Spradling, Philip R. TI Duration of Protection After Infant Hepatitis B Vaccination Series SO PEDIATRICS LA English DT Article DE infant immunization; hepatitis B vaccine; hepatitis B; adolescent immunization ID LONG-TERM IMMUNOGENICITY; ADOLESCENTS; VACCINES; IMMUNITY; BOOSTER; PERSISTENCE; CHILDREN; BIRTH; MODELS; GENES AB BACKGROUND: Little is known about duration of protection after the infant primary series of hepatitis B (HB) vaccine in settings of low HB endemicity. This study sought to determine the proportion of adolescents immunized as infants who had protective titers of antibody to hepatitis B surface antigen (anti-HBs) before and after a challenge dose of vaccine. METHODS: US-born 16-through 19-year-olds who received a recombinant HB vaccine 3-dose series initiated within 7 days of birth (group 1) or at >= 4 weeks of age (group 2) and completed by 12 months of age were enrolled. Participants had serologic testing before and 2 weeks after randomization to receive a challenge dose of 10 mu g or 20 mg of Engerix-B. Baseline and postchallenge levels of anti-HBs were compared by group, challenge dosage, and demographic and behavioral characteristics. RESULTS: At baseline, 24% had protective anti-HBs levels of >= 10 IU/mL; 92% achieved protective levels after challenge dose. Although group 1 had a lower proportion of seroprotection at baseline, group and challenge dosage were not associated with postchallenge proportion of seroprotection. Being in group 2, higher test dosage, higher baseline geometric mean titer, and nonwhite race were associated with significantly higher geometric mean titer after challenge dose. CONCLUSIONS: More than 90% of study participants immunized against HB as infants exhibited a seroprotective response to a challenge dose of vaccine. Duration of protection from the primary infant HB vaccine series extended through the adolescent years in the setting of low HB endemicity. C1 [Middleman, Amy B.] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Oklahoma City, OK 73190 USA. [Baker, Carol J.; Kozinetz, Claudia A.; Chi Nguyen] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA. [Kamili, Saleem; Hu, Dale J.; Spradling, Philip R.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Middleman, AB (reprint author), OU Childrens Phys, Dept Pediat, 1200 Childrens Ave,Ste 12200, Oklahoma City, OK 73104 USA. EM amym@ouhsc.edu FU Centers for Disease Control and Prevention project [00HCVJHB-2009-67553] FX This project was contracted and funded by the Centers for Disease Control and Prevention project 00HCVJHB-2009-67553. NR 26 TC 9 Z9 12 U1 0 U2 4 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD JUN PY 2014 VL 133 IS 6 BP E1500 EP E1507 DI 10.1542/peds.2013-2940 PG 8 WC Pediatrics SC Pediatrics GA AI8MY UT WOS:000337172600003 PM 24843060 ER PT J AU Pettersson, E Mendle, J Turkheimer, E Horn, EE Ford, DC Simms, LJ Clark, LA AF Pettersson, Erik Mendle, Jane Turkheimer, Eric Horn, Erin E. Ford, Derek C. Simms, Leonard J. Clark, Lee Anna TI Do Maladaptive Behaviors Exist at One or Both Ends of Personality Traits? SO PSYCHOLOGICAL ASSESSMENT LA English DT Article DE personality pathology; personality disorders; general factor; evaluation; social desirability ID 5-FACTOR MODEL; GENERAL FACTOR; SOCIAL DESIRABILITY; ADAPTIVE PERSONALITY; PSYCHIATRIC-PATIENT; EMPIRICAL SUPPORT; DIMENSIONAL MODEL; EEG ASYMMETRY; DISORDERS; SELF AB In the Diagnostic and Statistical Manual of Mental Disorders (5th ed.; American Psychiatric Association, 2013) personality disorder trait model, maladaptive behavior is located at one end of continuous scales. Widiger and colleagues, however, have argued that maladaptive behavior exists at both ends of trait continua. We propose that the role of evaluative variance differentiates these two perspectives and that once evaluation is isolated, maladaptive behaviors emerge at both ends of nonevaluative trait dimensions. In Study 1, we argue that evaluative variance is worthwhile to measure separately from descriptive content because it clusters items by valence regardless of content (e. g., lazy and workaholic; apathetic and anxious; gullible and paranoid; timid and hostile, etc.), which is unlikely to describe a consistent behavioral style. We isolate evaluation statistically (Study 2) and at the time of measurement (Study 3) to show that factors unrelated to valence evidence maladaptive behavior at both ends. We argue that nonevaluative factors, which display maladaptive behavior at both ends of continua, may better approximate ways in which individuals actually behave. C1 [Pettersson, Erik] Karolinska Inst, S-17177 Stockholm, Sweden. [Mendle, Jane] Cornell Univ, Dept Human Dev, Ithaca, NY 14853 USA. [Turkheimer, Eric; Horn, Erin E.] Univ Virginia, Dept Psychol, Charlottesville, VA 22903 USA. [Ford, Derek C.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Simms, Leonard J.] SUNY Buffalo, Dept Psychol, Buffalo, NY 14260 USA. [Clark, Lee Anna] Univ Notre Dame, Dept Psychol, Notre Dame, IN 46556 USA. RP Pettersson, E (reprint author), Karolinska Inst, Box 281, S-17177 Stockholm, Sweden. EM erik.pettersson@ki.se NR 82 TC 4 Z9 4 U1 3 U2 9 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 1040-3590 EI 1939-134X J9 PSYCHOL ASSESSMENT JI Psychol. Assess. PD JUN PY 2014 VL 26 IS 2 BP 433 EP 446 DI 10.1037/a0035587 PG 14 WC Psychology, Clinical SC Psychology GA AJ5EU UT WOS:000337706000009 PM 24490679 ER PT J AU Moro, PL Museru, OI Niu, M Lewis, P Broder, K AF Moro, Pedro L. Museru, Oidda I. Niu, Manette Lewis, Paige Broder, Karen TI Reports to the Vaccine Adverse Event Reporting System after hepatitis A and hepatitis AB vaccines in pregnant women SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE hepatitis A hepatitis B combined vaccine; hepatitis A vaccine; pregnancy; surveillance; vaccine safety ID B-VACCINE; SAFETY; VAERS; IMMUNIZATION; SURVEILLANCE AB OBJECTIVE: To characterize adverse events (AEs) after hepatitis A vaccines (Hep A) and hepatitis A and hepatitis B combination vaccine (Hep AB) in pregnant women reported to the Vaccine Adverse Event Reporting System (VAERS), a spontaneous reporting surveillance system. STUDY DESIGN: We searched VAERS for AEs reports in pregnant women who received Hep A or Hep AB from Jan. 1, 1996-April 5, 2013. Clinicians reviewed all reports and available medical records. RESULTS: VAERS received 139 reports of AEs in pregnant women; 7 (5.0%) were serious; no maternal or infant deaths were identified. Sixty-five (46.8%) did not describe any AEs. For those women whose gestational age was available, most were vaccinated during the first trimester, 50/60 (83.3%) for Hep A and 18/21 (85.7%) for Hep AB. The most common pregnancy-specific outcomes following Hep A or Hep AB vaccinations were spontaneous abortion in 15 (10.8%) reports, elective termination in 10 (7.2%), and preterm delivery in 7 (5.0%) reports. The most common nonpregnancy specific outcome was urinary tract infection and nausea/vomiting with 3 (2.2%) reports each. One case of amelia of the lower extremities was reported in an infant following maternal Hep A immunization. CONCLUSION: This review of VAERS reports did not identify any concerning pattern of AEs in pregnant women or their infants following maternal Hep A or Hep AB immunizations during pregnancy. C1 [Moro, Pedro L.; Museru, Oidda I.; Lewis, Paige; Broder, Karen] Ctr Dis Control & Prevent, Immunizat Safety Off, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. [Niu, Manette] US FDA, Ctr Biol Evaluat & Res, Rockville, MD 20857 USA. RP Moro, PL (reprint author), Ctr Dis Control & Prevent, Immunizat Safety Off, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. NR 26 TC 4 Z9 4 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 EI 1097-6868 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JUN PY 2014 VL 210 IS 6 AR 561.e1 DI 10.1016/j.ajog.2013.12.036 PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA AI1CS UT WOS:000336588000022 PM 24378675 ER PT J AU Mixson-Hayden, T Lee, D Ganova-Raeva, L Drobeniuc, J Stauffer, WM Teshale, E Kamili, S AF Mixson-Hayden, Tonya Lee, Deborah Ganova-Raeva, Lilia Drobeniuc, Jan Stauffer, William M. Teshale, Eyasu Kamili, Saleem TI Hepatitis B Virus and Hepatitis C Virus Infections in United States-Bound Refugees from Asia and Africa SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID HEPATOCELLULAR-CARCINOMA; INTERNATIONAL MIGRANTS; GEOSENTINEL CLINICS; VIRAL-HEPATITIS; HBV INFECTION; PREVALENCE; GENOTYPES; THAILAND; SPECTRUM; ILLNESS AB The aim of this study was to determine the prevalence of active hepatitis B and C virus infections among refugees from various countries in Africa and Asia. Pre-admission serum samples collected during 2002-2007 from refugees originating from Bhutan (N = 755), Myanmar (N = 1076), Iraq (N = 1137), Laos (N = 593), Thailand (N = 622), and Somalia (N = 707) were tested for hepatitis B virus (HBV) DNA and hepatitis C virus (HCV) RNA. The HBV DNA (genotypes A, B, C, and G) was detected in 12.1% of samples negative for anti-HBs. Highest HBV prevalence was found among Hmong; lowest among Bhutanese. The HCV RNA (genotypes 1a, 1b, 1c, 3b, 6n, and 6m) was detected in 1.3% of the samples. Highest HCV prevalence was found among Hmong from Thailand; lowest among Iraqis. Screening specific refugee groups at high risk for viral hepatitis infections will identify infected individuals who could benefit from referral to care and treatment and prevent further transmissions. C1 [Mixson-Hayden, Tonya; Lee, Deborah; Ganova-Raeva, Lilia; Drobeniuc, Jan; Teshale, Eyasu; Kamili, Saleem] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30333 USA. [Stauffer, William M.] Univ Minnesota, Div Infect Dis & Int Med, Minneapolis, MN USA. RP Mixson-Hayden, T (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, 1600 Clifton Rd,MS A33, Atlanta, GA 30333 USA. EM zdy0@cdc.gov; dpl2@cdc.gov; lkg7@cdc.gov; jqd6@cdc.gov; stauf005@umn.edu; eht4@cdc.gov; sek6@cdc.gov NR 41 TC 5 Z9 5 U1 2 U2 9 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 2014 VL 90 IS 6 BP 1014 EP 1020 DI 10.4269/ajtmh.14-0068 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AI4FD UT WOS:000336820200007 PM 24732462 ER PT J AU Scobie, HM Nilles, E Kama, M Kool, JL Mintz, E Wannemuehler, KA Hyde, TB Dawainavesi, A Singh, S Korovou, S Jenkins, K Date, K AF Scobie, Heather M. Nilles, Eric Kama, Mike Kool, Jacob L. Mintz, Eric Wannemuehler, Kathleen A. Hyde, Terri B. Dawainavesi, Akanisi Singh, Sheetalpreet Korovou, Samuel Jenkins, Kylie Date, Kashmira TI Impact of a Targeted Typhoid Vaccination Campaign Following Cyclone Tomas, Republic of Fiji, 2010 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID FEVER; EXPERIENCE; BURDEN; TRIAL AB After a category 4 cyclone that caused extensive population displacement and damage to water and sanitation infrastructure in Fiji in March 2010, a typhoid vaccination campaign was conducted as part of the post-disaster response. During June-December 2010, 64,015 doses of typhoid Vi polysaccharide vaccine were administered to persons >= 2 years of age, primarily in cyclone-affected areas that were typhoid endemic. Annual typhoid fever incidence decreased during the post-campaign year (2011) relative to preceding years (2008-2009) in three subdivisions where a large proportion of the population was vaccinated (incidence rate ratios and 95% confidence intervals: 0.23, 0.13-0.41; 0.24, 0.14-0.41; 0.58, 0.40-0.86), and increased or remained unchanged in 12 subdivisions where little to no vaccination occurred. Vaccination played a role in reducing typhoid fever incidence in high-incidence areas after a disaster and should be considered in endemic settings, along with comprehensive control measures, as recommended by the World Health Organization. C1 [Scobie, Heather M.; Nilles, Eric; Wannemuehler, Kathleen A.; Hyde, Terri B.; Date, Kashmira] Ctr Dis Control & Prevent, Global Immunizat Div, Epidem Intelligence Serv, Atlanta, GA 30333 USA. Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Surveillance Epidemiol & Lab Serv, Atlanta, GA 30333 USA. [Nilles, Eric] World Hlth Org, Div Pacific Tech Support, Suva, Fiji. [Scobie, Heather M.; Mintz, Eric; Wannemuehler, Kathleen A.; Hyde, Terri B.; Date, Kashmira] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA. [Kama, Mike; Dawainavesi, Akanisi] Fiji Ctr Communicable Dis Control, Suva, Fiji. [Singh, Sheetalpreet] Minist Hlth, Hlth Informat Unit, Suva, Fiji. Fiji Minist Hlth, Labasa, Fiji. [Jenkins, Kylie] Minist Hlth, Fiji Hlth Sect Improvement Program, Suva, Fiji. RP Scobie, HM (reprint author), Ctr Dis Control & Prevent, Global Immunizat Div, 1600 Clifton Rd,MS A04, Atlanta, GA 30333 USA. EM vih8@cdc.gov; nillese@wpro.who.int; mnkama02@gmail.com; koolj@wpro.whoint; edm1@cdc.gov; kpw9@cdc.gov; tkh4@cdc.gov; dawainavesia@wpro.who.int; sheetal.nagra@gmail.com; skorokou@yahoo.uk; kylie.jenkins@fhssp.org.fj; gln7@cdc.gov OI Nilles, Eric/0000-0001-7044-5257; Kool, Jacob/0000-0002-9605-2918 FU Centers for Disease Control and Prevention; World Health Organization FX Funding was provided by the Centers for Disease Control and Prevention and World Health Organization. NR 21 TC 7 Z9 7 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 2014 VL 90 IS 6 BP 1031 EP 1038 DI 10.4269/ajtmh.13-0728 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AI4FD UT WOS:000336820200010 PM 24710618 ER PT J AU Duval, BD Elrod, MG Gee, JE Chantratita, N Tandhavanant, S Limmathurotsakul, D Hoffmaster, AR AF Duval, Brea D. Elrod, Mindy G. Gee, Jay E. Chantratita, Narisara Tandhavanant, Sarunporn Limmathurotsakul, Direk Hoffmaster, Alex R. TI Short Report: Evaluation of a Latex Agglutination Assay for the Identification of Burkholderia pseudomallei and Burkholderia mallei SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PSEUDOMONAS-PSEUDOMALLEI; INFECTION AB Cases of melioidosis and glanders are rare in the United States, but the etiologic agents of each disease (Burkholderia pseudomallei and Burkholderia mallei, respectively) are classified as Tier 1 select agents because of concerns about their potential use as bioterrorism agents. A rapid, highly sensitive, and portable assay for clinical laboratories and field use is required. Our laboratory has further evaluated a latex agglutination assay for its ability to identify B. pseudomallei and B. mallei isolates. This assay uses a monoclonal antibody that specifically recognizes the capsular polysaccharide produced by B. pseudomallei and B. mallei, but is absent in closely related Burkholderia species. A total of 110 B. pseudomallei and B. mallei were tested, and 36 closely related Burkholderia species. The latex agglutination assay was positive for 109 of 110 (99.1% sensitivity) B. pseudomallei and B. mallei isolates tested. C1 Ctr Dis Control & Prevent, Bacterial Special Pathogens Branch, Atlanta, GA 30333 USA. Mahidol Univ, Fac Trop Med, Dept Microbiol & Immunol, Bangkok, Thailand. Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand. Mahidol Univ, Fac Trop Med, Dept Trop Hyg, Bangkok, Thailand. RP Hoffmaster, AR (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,MS G34, Atlanta, GA 30333 USA. EM BDuval@cdc.gov; MGElrod@cdc.gov; JGeel@cdc.gov; Narisara@tropmedres.ac; Sarunporn@tropmedres.ac; Direk@tropmedres.ac; amh9@cdc.gov NR 12 TC 3 Z9 3 U1 0 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 2014 VL 90 IS 6 BP 1043 EP 1046 DI 10.4269/ajtmh.14-0025 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AI4FD UT WOS:000336820200012 PM 24710616 ER PT J AU Eisen, RJ MacMillan, K Atiku, LA Mpanga, JT Zielinski-Gutierrez, E Graham, CB Boegler, KA Enscore, RE Gage, KL AF Eisen, Rebecca J. MacMillan, Katherine Atiku, Linda A. Mpanga, Joseph T. Zielinski-Gutierrez, Emily Graham, Christine B. Boegler, Karen A. Enscore, Russell E. Gage, Kenneth L. TI Identification of Risk Factors for Plague in the West Nile Region of Uganda SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID FLEAS CTENOCEPHALIDES-FELIS; EARLY-PHASE TRANSMISSION; ENDEMIC REGION; NORTHWESTERN UGANDA; YERSINIA-PESTIS; TANZANIA; RODENTS; SIPHONAPTERA; PREDICTORS; VILLAGES AB Plague is an often fatal, primarily flea-borne rodent-associated zoonosis caused by Yersinia pestis. We sought to identify risk factors for plague by comparing villages with and without a history of human plague cases within a model-defined plague focus in the West Nile Region of Uganda. Although rat (Rattus rattus) abundance was similar inside huts within case and control villages, contact rates between rats and humans (as measured by reported rat bites) and host-seeking flea loads were higher in case villages. In addition, compared with persons in control villages, persons in case villages more often reported sleeping on reed or straw mats, storing food in huts where persons sleep, owning dogs and allowing them into huts where persons sleep, storing garbage inside or near huts, and cooking in huts where persons sleep. Compared with persons in case villages, persons in control villages more commonly reported replacing thatch roofing, and growing coffee, tomatoes, onions, and melons in agricultural plots adjacent to their homesteads. Rodent and flea control practices, knowledge of plague, distance to clinics, and most care-seeking practices were similar between persons in case villages and persons in control villages. Our findings reinforce existing plague prevention recommendations and point to potentially advantageous local interventions. C1 [Eisen, Rebecca J.; MacMillan, Katherine; Zielinski-Gutierrez, Emily; Graham, Christine B.; Boegler, Karen A.; Enscore, Russell E.; Gage, Kenneth L.] Ctr Dis Control & Prevent, Bacterial Dis Branch, Div Vector Borne Dis, Natl Ctr Emerging & Zoonot Infect Dis, Ft Collins, CO 80522 USA. [Atiku, Linda A.; Mpanga, Joseph T.] Uganda Virus Res Inst, Plague Sect, Entebbe, Uganda. RP Eisen, RJ (reprint author), Ctr Dis Control & Prevent, Bacterial Dis Branch, Div Vector Borne Dis, Natl Ctr Emerging & Zoonot Infect Dis, POB 2087, Ft Collins, CO 80522 USA. EM dyn2@cdc.gov; iky4@cdc.gov; l.atikupraise@yahoo.com; joe1ug@msn.com; ezb0@cdc.gov; hyb4@cdc.gov; kje5@cdc.gov; renscore@cdc.gov; klg0@cdc.gov FU United States Agency for International Development Emerging Pandemic Threat Program FX This study was supported in part by the United States Agency for International Development Emerging Pandemic Threat Program. NR 51 TC 3 Z9 3 U1 1 U2 16 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 2014 VL 90 IS 6 BP 1047 EP 1058 DI 10.4269/ajtmh.14-0035 PG 12 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AI4FD UT WOS:000336820200013 PM 24686743 ER PT J AU Martin, DL Marks, M Galdos-Cardenas, G Gilman, RH Goodhew, B Ferrufino, L Halperin, A Sanchez, G Verastegui, M Escalante, P Naquira, C Levy, MZ Bern, C AF Martin, Diana L. Marks, Morgan Galdos-Cardenas, Gerson Gilman, Robert H. Goodhew, Brook Ferrufino, Lisbeth Halperin, Anthony Sanchez, Gerardo Verastegui, Manuela Escalante, Patricia Naquira, Cesar Levy, Michael Z. Bern, Caryn TI Regional Variation in the Correlation of Antibody and T-Cell Responses to Trypanosoma cruzi SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID CHAGAS-DISEASE; GENETIC-VARIABILITY; IMMUNE-RESPONSES; INTERFERON-GAMMA; INFECTION; BLOOD; ARGENTINA; TRANSMISSION; PATHOGENESIS; POPULATIONS AB Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is a major cause of morbidity and mortality in Central and South America. Geographic variations in the sensitivity of serologic diagnostic assays to T. cruzi may reflect differences in T cruzi exposure. We measured parasite-specific T-cell responses among seropositive individuals in two populations from South America with widely varying antibody titers against T. cruzi. Antibody titers among seropositive individuals were significantly lower in Arequipa, Peru compared with Santa Cruz, Bolivia. Similarly, the proportion of seropositive individuals with positive T-cell responses was lower in Peru than Bolivia, resulting in overall lower frequencies of interferon-gamma (IFN gamma)-secreting cells from Peruvian samples. However, the magnitude of the IFN gamma response was similar among the IFN gamma responders in both locations. These data indicate that immunological discrepancies based on geographic region are reflected in T-cell responses as well as antibody responses. C1 [Martin, Diana L.; Goodhew, Brook] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. NIH, Bethesda, MD 20892 USA. Johns Hopkins Univ, Baltimore, MD USA. [Galdos-Cardenas, Gerson; Ferrufino, Lisbeth] Hosp Univ Japones, Santa Cruz, Bolivia. [Galdos-Cardenas, Gerson; Ferrufino, Lisbeth] Asociac Benef PRISMA, Lima, Peru. [Gilman, Robert H.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Naquira, Cesar] Arequipa Minist Hlth, Arequipa, Peru. [Levy, Michael Z.] Univ Penn, Philadelphia, PA 19104 USA. [Sanchez, Gerardo; Verastegui, Manuela] Univ Peruana Cayetano Heredia, Lima, Peru. RP Martin, DL (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, MS D-65,1600 Clifton Rd NE, Atlanta, GA 30329 USA. EM hzx3@cdc.gov; mmarkster@gmail.com; gerson_galdos@yahoo.es; gilmanabob@gmail.com; isd6@cdc.gov; lisbeth_ferrufino@yahoo.es; gjsg2@hotmail.com; mveraste@jhsph.edu; patriciaeem2008@gmail.com; cesar.naquira@gmail.com; rnzlevy@mail.med.upenn.edu; Caryn.Bern2@ucsf.edu FU National Institutes of Health Tropical Medical Research Center [P50 AI074285]; National Institutes of Health Fogarty Scholars Program [R24 TW007988] FX This work was funded by National Institutes of Health Tropical Medical Research Center Grant P50 AI074285 and National Institutes of Health Fogarty Scholars Program Grant R24 TW007988. NR 35 TC 1 Z9 1 U1 1 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 2014 VL 90 IS 6 BP 1074 EP 1081 DI 10.4269/ajtmh.13-0391 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AI4FD UT WOS:000336820200016 PM 24710614 ER PT J AU Rodrigues, PT Alves, JMP Santamaria, AM Calzada, JE Xayavong, M Parise, M da Silva, AJ Ferreira, MU AF Rodrigues, Priscila T. Alves, Joao Marcelo P. Maria Santamaria, Ana Calzada, Jose E. Xayavong, Maniphet Parise, Monica da Silva, Alexandre J. Ferreira, Marcelo U. TI Using Mitochondrial Genome Sequences to Track the Origin of Imported Plasmodium vivax Infections Diagnosed in the United States SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ANCIENT POPULATION EXPANSION; FALCIPARUM-MALARIA; EVOLUTIONARY HISTORY; GEOGRAPHIC STRUCTURE; SRI-LANKA; RISK; TRANSMISSION; ELIMINATION; STRATEGIES; DIVERSITY AB Although the geographic origin of malaria cases imported into the United States can often be inferred from travel histories, these histories may be lacking or incomplete. We hypothesized that mitochondrial haplotypes could provide region-specific molecular barcodes for tracing the origin of imported Plasmodium vivax infections. An analysis of 348 mitochondrial genomes from worldwide parasites and new sequences from 69 imported malaria cases diagnosed across the United States allowed for a geographic assignment of most infections originating from the Americas, southeast Asia, east Asia, and Melanesia. However, mitochondrial lineages from Africa, south Asia, central Asia, and the Middle East, which altogether contribute the vast majority of imported malaria cases in the United States, were closely related to each other and could not be reliably assigned to their geographic origins. More mitochondrial genomes are required to characterize molecular barcodes of P. vivax from these regions. C1 [Rodrigues, Priscila T.; Alves, Joao Marcelo P.; Ferreira, Marcelo U.] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, BR-05508900 Sao Paulo, Brazil. [Maria Santamaria, Ana; Calzada, Jose E.] Gorgas Mem Inst Hlth, Dept Parasitol, Panama City, Panama. [Xayavong, Maniphet; Parise, Monica; da Silva, Alexandre J.] Ctr Dis Control & Prevent, Ctr Global Hlth, Div Parasit Dis & Malaria, Atlanta, GA USA. RP Ferreira, MU (reprint author), Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Av Prof Lineu Prestes 1374, BR-05508900 Sao Paulo, Brazil. EM priscilathihara@usp.br; alvesjmp@gmail.com; asantamaria@gorgas.gob.pa; jcalzada@gorgas.gob.pa; max1@cdc.gov; mep0l@cdc.gov; abs8@cdc.gov; muferrei@usp.br RI Alves, Joao/G-8927-2011; Ferreira, Marcelo/G-8289-2011 OI Alves, Joao/0000-0001-5914-2087; Ferreira, Marcelo/0000-0002-5293-9090 FU National Institutes of Health, United States [R01 AI 075416]; Centers for Disease Control and Prevention, United States; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Brazil [2010/50333-8]; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil [590106/2011-2]; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Brazil; CNPq; FAPESP FX This research was supported by funds from the National Institutes of Health, United States (Grant R01 AI 075416), the Centers for Disease Control and Prevention, United States, the Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Brazil (Grant 2010/50333-8), and Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil (Grant 590106/2011-2). P.T.R. received a scholarship from the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Brazil and is currently supported by CNPq. J.M.P.A. is currently supported by FAPESP. M.U.F. received a senior research scholarship from CNPq, Brazil. NR 37 TC 9 Z9 9 U1 0 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 2014 VL 90 IS 6 BP 1102 EP 1108 DI 10.4269/ajtmh.13-0588 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AI4FD UT WOS:000336820200021 PM 24639297 ER PT J AU Jones, JL Kruszon-Moran, D Rivera, HN Price, C Wilkins, PP AF Jones, Jeffrey L. Kruszon-Moran, Deanna Rivera, Hilda N. Price, Courtney Wilkins, Patricia P. TI Toxoplasma gondii Seroprevalence in the United States 2009-2010 and Comparison with the Past Two Decades SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID NATIONAL-HEALTH; MOOD DISORDERS; TISSUE CYSTS; RISK-FACTORS; INFECTION; SCHIZOPHRENIA; PORK AB Toxoplasma gondii is a ubiquitous parasite that can cause neurologic and ocular disease. We tested sera from 7,072 people >= 6 years of age in the 2009-2010 National Health and Nutrition Examination Survey (NHANES) for immunoglobulin G antibodies and compared these results with two previous NHANES studies. The overall T. gondii antibody seroprevalence among persons >= 6 years of age in 2009-2010 was 13.2% (95% confidence limit [CL] 11.8%, 14.5%) and age-adjusted seroprevalence was 12.4% (95% CL 11.1%, 13.7%); age-adjusted seroprevalence among women 15-44 years of age was 9.1% (95% CL 7.2%, 11.1%). In U.S. born persons 12-49 years of age, the age-adjusted T. gondii seroprevalence decreased from 14.1% (95% CL 12.7%, 15.5%) in NHANES III (1988-1994) to 9.0% (95% CL 7.6%, 10.5%) in NHANES 1999-2004 to 6.7% (95% CL 5.3%, 8.2%) in NHANES 2009-2010 (P < 0.001 linear trend). Although T. gondii antibody presence is still relatively common, the prevalence in the United States has continued to decline. C1 [Jones, Jeffrey L.; Rivera, Hilda N.; Price, Courtney; Wilkins, Patricia P.] Ctr Dis Control & Prevent, Parasit Dis Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30333 USA. [Kruszon-Moran, Deanna] Ctr Dis Control & Prevent, Div Hlth & Nutr Examinat Stat, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. RP Jones, JL (reprint author), Ctr Dis Control & Prevent, Parasit Dis Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, Bld 24,1600 Clifton Rd,NE,Mailstop A-06, Atlanta, GA 30333 USA. EM jlj1@cdc.gov; ddko@cdc.gov; igi2@cdc.gov; www4@cdc.gov; pma1@cdc.gov NR 27 TC 25 Z9 25 U1 0 U2 9 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 2014 VL 90 IS 6 BP 1135 EP 1139 DI 10.4269/ajtmh.14-0013 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AI4FD UT WOS:000336820200027 PM 24710615 ER PT J AU Sibai, AM Tohme, RA Almedawar, MM Itani, T Yassine, SI Nohra, EA Isma'eel, HA AF Sibai, Abla M. Tohme, Rania A. Almedawar, Mohamad M. Itani, Taha Yassine, Sara I. Nohra, Eden A. Isma'eel, Hussain A. TI Lifetime cumulative exposure to waterpipe smoking is associated with coronary artery disease SO ATHEROSCLEROSIS LA English DT Article DE Waterpipe smoking; Coronary artery disease; Heart disease; Case-control study ID HEART-RATE-VARIABILITY; TOBACCO SMOKING; PIPE SMOKING; RISK; ATTITUDES; BEHAVIOR; BELIEFS AB Objective: Globally, waterpipe (WP) smoking is becoming a more prevalent form of tobacco consumption. Whilst research so far has demonstrated a significant link between WP use and a number of health outcomes, little is known of its association with heart disease. We examine in this study the association of WP smoking with angiographically confirmed coronary artery disease (CAD). Methods: A total of 1210 patients, aged 40 years and over and free from smoking-associated illnesses or history of cardiovascular procedures, admitted for coronary angiography at four major hospitals in Lebanon, were included. The extent of CAD was summarized in two ways, firstly as diseased (>= 50% and >= 70% occlusion in at least one main coronary artery) versus non-diseased (entirely normal coronaries), and secondly, as CAD cumulative score based on Duke CAD Prognostic Index. A score of WP-years, capturing intensity and lifetime duration of exposure, was estimated for each individual. Results: Lifetime exposure exceeding 40 WP-years was associated with a threefold significant increase in the odds of having severe stenosis (>= 70%) compared to non-smokers (OR = 2.94, 95% CI = 1.04-8.33) as well as with the CAD Index (beta = 7.835, p-value = 0.027), net of the effect of socio-demographic characteristics, health behaviors and co-morbidity. A dose-response relationship between WP-years and percent stenosis was also established. WP smoking status (never, past and current) did not associate with CAD. Conclusions: Cumulative exposure to WP smoking is significantly associated with severe CAD. There is a need to monitor WP use among cardiac patients and include this information in their medical charts in the same manner cigarettes smoking is documented. This is likely to increase awareness of the hazards of WP smoking and prompt physicians to target WP tobacco control by providing advice to their patients on WP smoking cessation. (C) 2014 Elsevier Ireland Ltd. All rights reserved. C1 [Sibai, Abla M.; Tohme, Rania A.; Yassine, Sara I.] Amer Univ Beirut, Fac Hlth Sci, Dept Epidemiol & Populat Hlth, Beirut 11072020, Lebanon. [Tohme, Rania A.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Almedawar, Mohamad M.; Isma'eel, Hussain A.] Amer Univ Beirut, Med Ctr, Dept Internal Med, Beirut 11072020, Lebanon. [Almedawar, Mohamad M.; Isma'eel, Hussain A.] Amer Univ Beirut, Med Ctr, Vasc Med Program, Beirut 11072020, Lebanon. [Itani, Taha] Univ Bielefeld, Sch Publ Hlth, Dept Publ Hlth Med, D-33615 Bielefeld, Germany. [Nohra, Eden A.] Amer Univ Beirut, Med Ctr, Dept Surg, Beirut 11072020, Lebanon. RP Isma'eel, HA (reprint author), Amer Univ Beirut, Med Ctr, Cairo St,POB 11-0236, Beirut 11072020, Lebanon. EM hi09@aub.edu.lb OI Sibai, Abla/0000-0002-1851-5606 FU International Development Research Centre (IDRC-EDR) [103436-001] FX This work was supported by the International Development Research Centre (IDRC-EDR) [grant number 103436-001] to [AMS]. The funding source had no role in the study design, conduct or analysis; in the writing of the paper or the decision to submit the paper for publication. NR 29 TC 15 Z9 15 U1 0 U2 4 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0021-9150 EI 1879-1484 J9 ATHEROSCLEROSIS JI Atherosclerosis PD JUN PY 2014 VL 234 IS 2 BP 454 EP 460 DI 10.1016/j.atherosclerosis.2014.03.036 PG 7 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA AH9CT UT WOS:000336439000032 PM 24814409 ER PT J AU Ellis, MW Schlett, CD Millar, EV Wilkins, KJ Crawford, KB Morrison-Rodriguez, SM Pacha, LA Gorwitz, RJ Lanier, JB Tribble, DR AF Ellis, Michael W. Schlett, Carey D. Millar, Eugene V. Wilkins, Kenneth J. Crawford, Katrina B. Morrison-Rodriguez, Stephanie M. Pacha, Laura A. Gorwitz, Rachel J. Lanier, Jeffrey B. Tribble, David R. TI Hygiene Strategies to Prevent Methicillin-Resistant Staphylococcus aureus Skin and Soft Tissue Infections: A Cluster-Randomized Controlled Trial Among High-Risk Military Trainees SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE Staphylococcus aureus; methicillin-resistant Staphylococcus aureus (MRSA); skin and soft tissue infection; chlorhexidine; military ID HOUSEHOLD CONTACTS; MARINE RECRUITS; UNITED-STATES; COLONIZATION; EPIDEMIOLOGY; CELLULITIS; CHILDREN; PREVALENCE; CALIFORNIA; MUPIROCIN AB Background. Effective measures are needed to prevent methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infections (SSTIs) in high-risk community settings. The study objective was to evaluate the effect of personal hygiene-based strategies on rates of overall SSTI and MRSA SSTI. Methods. We conducted a prospective, field-based, cluster-randomized trial in US Army Infantry trainees from May 2010 through January 2012. There were 3 study groups with incrementally increased education and hygiene-based interventions: standard (S), enhanced standard (ES), and chlorhexidine (CHG). The primary endpoints were incidence of overall SSTI and MRSA SSTI. Results. The study included 30 209 trainees constituting 540 platoons (168 S, 192 ES, and 180 CHG). A total of 1203 (4%) participants developed SSTI, 316 (26%) due to MRSA. The overall SSTI rate was 4.15 (95% confidence interval [CI], 3.77-4.58) per 100 person-cycles. SSTI rates by study group were 3.48 (95% CI, 2.87-4.22) for S, 4.18 (95% CI, 3.56-4.90) for ES, and 4.71 (95% CI, 4.03-5.50) for CHG. The MRSA SSTI rate per 100 person-cycles for all groups was 1.10 (95% CI,.91-1.32). MRSA SSTI rates by study group were 1.0 (95% CI,.70-1.42) for S, 1.29 (95% CI,.98-1.71) for ES, and 0.97 (95% CI,.70-1.36) for CHG. Conclusions. Personal hygiene and education measures, including once-weekly use of chlorhexidine body wash, did not prevent overall SSTI or MRSA SSTI in a high-risk population of military trainees. C1 [Ellis, Michael W.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [Schlett, Carey D.; Millar, Eugene V.; Crawford, Katrina B.; Morrison-Rodriguez, Stephanie M.; Tribble, David R.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Wilkins, Kenneth J.] NIDDK, NIH, Bethesda, MD 20892 USA. [Pacha, Laura A.] US Army Publ Hlth Command, Army Inst Publ Hlth, Aberdeen Proving Ground, MD USA. [Gorwitz, Rachel J.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Lanier, Jeffrey B.] Martin Army Community Hosp, Ft Benning, GA USA. RP Ellis, MW (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM michael.ellis@usuhs.edu FU Infectious Disease Clinical Research Program, a DoD program through the Uniformed Services University of the Health Sciences; National Institute of Allergy and Infectious Diseases, National Institutes of Health [Y1-AI-5072]; CDC, National Center for Emerging and Zoonotic Infectious Diseases, Division of Healthcare Quality Promotion [09FED914272]; DoD Global Emerging Infections Surveillance program [C0366-11-HS] FX The work was supported by the Infectious Disease Clinical Research Program, a DoD program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (Interagency Agreement Y1-AI-5072). Additional funding was provided by CDC, National Center for Emerging and Zoonotic Infectious Diseases, Division of Healthcare Quality Promotion (Interagency Agreement (09FED914272 to M. W. E.), and the DoD Global Emerging Infections Surveillance program (C0366-11-HS to M. W. E.). NR 38 TC 15 Z9 15 U1 0 U2 5 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JUN 1 PY 2014 VL 58 IS 11 BP 1540 EP 1548 DI 10.1093/cid/ciu166 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AI7AL UT WOS:000337031200009 PM 24633684 ER PT J AU Patton, ME Kidd, S Llata, E Stenger, M Braxton, J Asbel, L Bernstein, K Gratzer, B Jespersen, M Kerani, R Mettenbrink, C Mohamed, M Pathela, P Schumacher, C Stirland, A Stover, J Tabidze, I Kirkcaldy, RD Weinstock, H AF Patton, Monica E. Kidd, Sarah Llata, Eloisa Stenger, Mark Braxton, Jim Asbel, Lenore Bernstein, Kyle Gratzer, Beau Jespersen, Megan Kerani, Roxanne Mettenbrink, Christie Mohamed, Mukhtar Pathela, Preeti Schumacher, Christina Stirland, Ali Stover, Jeff Tabidze, Irina Kirkcaldy, Robert D. Weinstock, Hillard TI Extragenital Gonorrhea and Chlamydia Testing and Infection Among Men Who Have Sex With Men-STD Surveillance Network, United States, 2010-2012 SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE extragenital gonorrhea; extragenital chlamydia; men who have sex with men (MSM); STD ID NEISSERIA-GONORRHOEAE; HIV-INFECTION; GONOCOCCAL INFECTION; RECTAL GONORRHEA; HOMOSEXUAL-MEN; SAN-FRANCISCO; BISEXUAL MEN; TRACHOMATIS; PHARYNGEAL; HEALTH AB Background. Gonorrhea (GC) and chlamydia (CT) are the most commonly reported notifiable diseases in the United States. The Centers for Disease Control and Prevention recommends that men who have sex with men (MSM) be screened for urogenital GC/CT, rectal GC/CT, and pharyngeal GC. We describe extragenital GC/CT testing and infections among MSM attending sexually transmitted disease (STD) clinics. Methods. The STD Surveillance Network collects patient data from 42 STD clinics. We assessed the proportion of MSM attending these clinics during July 2011-June 2012 who were tested and positive for extragenital GC/CT at their most recent visit or in the preceding 12 months and the number of extragenital infections that would have remained undetected with urethral screening alone. Results. Of 21 994 MSM, 83.9% were tested for urogenital GC, 65.9% for pharyngeal GC, 50.4% for rectal GC, 81.4% for urogenital CT, 31.7% for pharyngeal CT, and 45.9% for rectal CT. Of MSM tested, 11.1% tested positive for urogenital GC, 7.9% for pharyngeal GC, 10.2% for rectal GC, 8.4% for urogenital CT, 2.9% for pharyngeal CT, and 14.1% for rectal CT. More than 70% of extragenital GC infections and 85% of extragenital CT infections were associated with negative urethral tests at the same visit and would not have been detected with urethral screening alone. Conclusions. Extragenital GC/CT was common among MSM attending STD clinics, but many MSM were not tested. Most extragenital infections would not have been identified, and likely would have remained untreated, with urethral screening alone. Efforts are needed to facilitate implementation of extragenital GC/CT screening recommendations for MSM. C1 [Patton, Monica E.; Kidd, Sarah; Llata, Eloisa; Stenger, Mark; Braxton, Jim; Kirkcaldy, Robert D.; Weinstock, Hillard] Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30316 USA. [Patton, Monica E.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA 30316 USA. [Asbel, Lenore] Philadelphia Hlth Dept, Philadelphia, PA USA. [Bernstein, Kyle] San Francisco Dept Publ Hlth, San Francisco, CA USA. [Gratzer, Beau] Howard Brown Hlth Ctr, Chicago, IL USA. [Jespersen, Megan] Louisiana Off Publ Hlth, Baton Rouge, LA USA. [Kerani, Roxanne] Publ Hlth Seattle & King Cty, Seattle, WA USA. [Kerani, Roxanne] Univ Washington, Seattle, WA 98195 USA. [Mettenbrink, Christie] Denver Publ Hlth Dept, Denver, CO USA. [Mohamed, Mukhtar] Connecticut Dept Publ Hlth, Hartford, CT USA. [Pathela, Preeti] New York City Dept Hlth & Mental Hyg, New York, NY USA. [Schumacher, Christina] Baltimore City Dept Hlth, Baltimore, MD USA. [Schumacher, Christina] Johns Hopkins Sch Med, Baltimore, MD USA. [Stirland, Ali] Los Angeles Cty Dept Publ Hlth, Los Angeles, CA USA. [Stover, Jeff] Virginia Dept Hlth, Richmond, VA USA. [Tabidze, Irina] Chicago Div Publ Hlth, Chicago, IL USA. RP Patton, ME (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, 1600 Clifton Rd,MS E02, Atlanta, GA 30316 USA. EM gnh9@cdc.gov FU Centers for Disease Control and Prevention, Division of STD Prevention, STD Surveillance Network [CDC RFA PS08-865] FX This work was supported by the Centers for Disease Control and Prevention, Division of STD Prevention, STD Surveillance Network (CDC RFA PS08-865). NR 31 TC 30 Z9 30 U1 0 U2 8 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JUN 1 PY 2014 VL 58 IS 11 BP 1564 EP 1570 DI 10.1093/cid/ciu184 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AI7AL UT WOS:000337031200012 PM 24647015 ER PT J AU Wagenaar, JA van Bergen, MAP Blaser, MJ Tauxe, RV Newell, DG van Putten, JPM AF Wagenaar, Jaap A. van Bergen, Marcel A. P. Blaser, Martin J. Tauxe, Robert V. Newell, Diane G. van Putten, Jos P. M. TI Campylobacter fetus Infections in Humans: Exposure and Disease SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE Campylobacter fetus; food safety; exposure; immunocompromised ID SUBSP FETUS; CLINICAL-FEATURES; S-LAYER; BACTEREMIA; SPP.; IDENTIFICATION; CONTAMINATION; PATHOGENESIS; PREVALENCE; MECHANISMS AB Campylobacter fetus can cause intestinal illness and, occasionally, severe systemic infections. Infections mainly affect persons at higher risk, including elderly and immunocompromised individuals and those with occupational exposure to infected animals. Outbreaks are infrequent but have provided insight into sources. Source attribution of sporadic cases through case-control interviews has not been reported. The reservoirs for C. fetus are mainly cattle and sheep. Products from these animals are suspected as sources for human infections. Campylobacter fetus is rarely isolated from food, albeit selective isolation methods used in food microbiology are not suited for its detection. We hypothesize that the general population is regularly exposed to C. fetus through foods of animal origin, cross-contaminated foodstuffs, and perhaps other, as yet unidentified, routes. Campylobacter fetus infection should be suspected particularly in patients with nonspecific febrile illness who are immunocompromised or who may have been occupationally exposed to ruminants. C1 [Wagenaar, Jaap A.; van Putten, Jos P. M.] Univ Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Lelystad, Netherlands. [Wagenaar, Jaap A.; van Bergen, Marcel A. P.] Wageningen UR, Cent Vet Inst, Lelystad, Netherlands. [Wagenaar, Jaap A.; van Bergen, Marcel A. P.; van Putten, Jos P. M.] World Hlth Org Collaborating Ctr Campylobacter, OIE Reference Lab Campylobacteriosis, Utrecht, Netherlands. [Blaser, Martin J.] NYU, Sch Med, Dept Med, New York, NY USA. [Tauxe, Robert V.] Ctr Dis Control & Prevent, Div Foodborne Bacterial & Mycot Dis, Atlanta, GA USA. [Newell, Diane G.] Food Borne Zoonoses Consultancy, Wherwell, Andover, England. RP Wagenaar, JA (reprint author), Univ Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, POB 80-165, NL-3508 TD Utrecht, Netherlands. EM j.wagenaar@uu.nl OI van Putten, Jos/0000-0002-4126-8172 FU Diane Belfer Program in Human Microbial Ecology FX This work was supported in part by the Diane Belfer Program in Human Microbial Ecology. NR 61 TC 13 Z9 13 U1 1 U2 25 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JUN 1 PY 2014 VL 58 IS 11 BP 1579 EP 1586 DI 10.1093/cid/ciu085 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AI7AL UT WOS:000337031200015 PM 24550377 ER PT J AU Hinton, CF Mai, CT Nabukera, SK Botto, LD Feuchtbaum, L Romitti, PA Wang, Y Piper, KN Olney, RS AF Hinton, Cynthia F. Mai, Cara T. Nabukera, Sarah K. Botto, Lorenzo D. Feuchtbaum, Lisa Romitti, Paul A. Wang, Ying Piper, Kimberly Noble Olney, Richard S. TI Developing a public health-tracking system for follow-up of newborn screening metabolic conditions: a four-state pilot project structure and initial findings SO GENETICS IN MEDICINE LA English DT Article DE long-term follow-up; newborn streening metabolic disorders; public health surveillance ID SERVICES ADVISORY-COMMITTEE; HERITABLE DISORDERS; INFORMATION-SYSTEM; UNITED-STATES; US SECRETARY; CHILDREN; COLLECTION; GUIDELINES; DIAGNOSIS; PROGRAMS AB Purpose: The aim of this study was to describe the methods, cases, and initial results of a pilot project using existing public health data collection programs (birth defect surveillance or newborn screening) to conduct long-term follow-up of children with metabolic disorders. Methods: California, Iowa, New York, and Utah expanded birth defect surveillance or newborn screening programs to collect long-term follow-up data on 19 metabolic disorders. Data elements to monitor health status and services delivered were identified, and record abstraction and data linkages were conducted. Children were followed up through to the age of 3 years. Results: A total of 261 metabolic cases were diagnosed in 1,343,696 live births (19.4 cases/100,000; 95% confidence interval = 17.1-21.8). Four deaths were identified. Children with fatty acid oxidation disorders had a higher percentage of health service encounters compared with children with other disorders of at least one health service encounter (hospitalization, emergency room, metabolic clinic, genetic service provider, or social worker) except for hospitalizations; children with organic acid disorders had a higher percentage of at least one hospitalization during their third year of life than children with other disorders. Conclusion: Existing public health data programs can be leveraged to conduct population-based newborn screening long-term follow-up. This approach is flexible according to state needs and resources. These data will enable the states in assessing health burden, assuring access to services, and supporting policy development. C1 [Hinton, Cynthia F.; Mai, Cara T.; Olney, Richard S.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Nabukera, Sarah K.] Social & Sci Syst, Silver Spring, MD USA. [Botto, Lorenzo D.] Univ Utah, Dept Pediat, Div Med Genet, Salt Lake City, UT USA. [Feuchtbaum, Lisa] Calif Dept Publ Hlth, Genet Dis Screening Program, Sacramento, CA USA. [Romitti, Paul A.] Univ Iowa, Iowa City, IA USA. [Wang, Ying] New York State Dept Hlth, Albany, NY USA. [Piper, Kimberly Noble] Iowa Dept Publ Hlth, Des Moines, IA 50319 USA. RP Hinton, CF (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. EM chinton@cdc.gov FU National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention (CDC) [DD08-810] FX This project was supported in part by the cooperative agreement. no. DD08-810 from the National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention (CDC). We acknowledge key individuals who contributed to the project: Christopher Johnson and Marilyn Sango-Jordan for newborn screening data and preparing the final data set in New York; Sunaina Dowray and Jennifer Carter for data coordination and management in California; Aliese Franck, Marcia L. Feldkamp, Amy E. Nance, and Miland Palmer for data abstraction and database preparation and support in Utah; Jan Vanderflugt, Florence Foo, and Carrie Fall for data abstraction in Iowa. In addition, we thank Coleen Boyle, Margaret Honein, Harry Hannon, and Carla Cuthbert from the CDC for their support of the project. NR 24 TC 4 Z9 4 U1 0 U2 5 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1098-3600 EI 1530-0366 J9 GENET MED JI Genet. Med. PD JUN PY 2014 VL 16 IS 6 BP 484 EP 490 DI 10.1038/gim.2013.177 PG 7 WC Genetics & Heredity SC Genetics & Heredity GA AI6UF UT WOS:000337011800009 PM 24310309 ER PT J AU Conklin, L Sejvar, JJ Kieszak, S Sabogal, R Sanchez, C Flanders, D Tulloch, F Victoria, G Rodriguez, G Sosa, N McGeehin, MA Schier, JG AF Conklin, Laura Sejvar, James J. Kieszak, Stephanie Sabogal, Raquel Sanchez, Carlos Flanders, Dana Tulloch, Felicia Victoria, Gerardo Rodriguez, Giselle Sosa, Nestor McGeehin, Michael A. Schier, Joshua G. TI Long-term Renal and Neurologic Outcomes Among Survivors of Diethylene Glycol Poisoning SO JAMA INTERNAL MEDICINE LA English DT Article ID METABOLITE; INGESTION; EPIDEMIC; TOXICITY; PANAMA AB IMPORTANCE At least 13 medication-associated diethylene glycol (DEG) mass poisonings have occurred since 1937. To our knowledge, this is the first longitudinal study characterizing long-term health outcomes among survivors beyond the acute poisoning period. OBJECTIVE To characterize renal and neurologic outcomes among survivors of a 2006 DEG mass-poisoning event in Panama for 2 years after exposure. DESIGN, SETTING, AND PARTICIPANTS This prospective longitudinal study used descriptive statistics and mixed-effects repeated-measures analysis to evaluate DEG-poisoned survivors at 4 consecutive 6-month intervals (0, 6, 12, and 18 months). Case patients included outbreak survivors with a history of (1) ingestion of DEG-contaminated medication, (2) hospitalization for DEG poisoning, and (3) an unexplained serum creatinine level of 1.5 mg/dL or higher (to convert to micromoles per liter, multiply by 88.4) during acute illness or unexplained exacerbation of preexisting end-stage renal disease. MAIN OUTCOMES AND MEASURES Demographics, mortality, dialysis dependence, renal function, neurologic signs and symptoms, and nerve conduction studies. RESULTS Of the 32 patients enrolled, 5 (15.6%) died and 1 was lost to follow-up, leaving 26 patients at 18 months. Three (9.4%) missed 1 or more evaluations. The median age was 62 years (range, 15-88 years), and 59.4% were female. Three (9.4%) patients had preexisting renal failure. Enrollment evaluations occurred at a median of 108 days (range, 65-154 days) after acute illness. The median serum creatinine level for the 22 patients who were not dialysis dependent at time 0 was 5.9 mg/dL (range, 1.8-17.1 mg/dL) during acute illness and 1.8 mg/dL (range, 0.9-5.9 mg/dL) at time 0. Among non-dialysis-dependent patients, there were no significant differences in the log of serum creatinine or estimated glomerular filtration rate over time. The number of patients with subjective generalized weakness declined significantly over time (P < .001). A similar finding was observed for any sensory loss (P = .05). The most common deficits at enrollment were bilateral lower extremity numbness in 13 patients (40.6%) and peripheral facial nerve motor deficits in 7 (21.9%). All patients with neurologic deficits at enrollment demonstrated improvement in motor function over time. Among 28 patients (90.3%) with abnormal nerve conduction study findings at enrollment, 10 (35.7%) had motor axonal involvement, the most common primary abnormality. CONCLUSIONS AND RELEVANCE Neurologic findings of survivors tended to improve over time. Renal function generally improved among non-dialysis-dependent patients between acute illness and the first evaluation with little variability thereafter. No evidence of delayed-onset neurologic or renal disease was observed. C1 [Conklin, Laura; Kieszak, Stephanie; Sabogal, Raquel; Sanchez, Carlos; Flanders, Dana; McGeehin, Michael A.; Schier, Joshua G.] Ctr Dis Control & Prevent, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA. [Sejvar, James J.] Ctr Dis Control & Prevent, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Dis, Atlanta, GA 30333 USA. [Rodriguez, Giselle] Caja Seguro Social, Panama City, Panama. [Sosa, Nestor] Gorgas Mem Inst, Panama City, Panama. [Schier, Joshua G.] Emory Univ, Sch Med, Dept Emergency Med, Atlanta, GA USA. RP Conklin, L (reprint author), Ctr Dis Control & Prevent, Mail Stop A-04,1600 Clifton Rd, Atlanta, GA 30333 USA. EM lconklin@cdc.gov FU Conklin; Tulloch; Schier FX Obtained funding: Conklin, Tulloch, Schier. NR 13 TC 6 Z9 6 U1 1 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD JUN PY 2014 VL 174 IS 6 BP 912 EP 917 DI 10.1001/jamainternmed.2014.344 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA AI4OA UT WOS:000336843500023 PM 24819553 ER PT J AU Decker, SL Kenney, GM Long, SK AF Decker, Sandra L. Kenney, Genevieve M. Long, Sharon K. TI Characteristics of Uninsured Low-Income Adults in States Expanding vs Not Expanding Medicaid SO JAMA INTERNAL MEDICINE LA English DT Letter C1 [Decker, Sandra L.] Ctr Dis Control & Prevent, Hyattsville, MD 20782 USA. [Kenney, Genevieve M.; Long, Sharon K.] Urban Inst, Washington, DC 20037 USA. RP Decker, SL (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, 3311 Toledo Rd, Hyattsville, MD 20782 USA. EM sdecker@cdc.gov NR 2 TC 4 Z9 4 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD JUN PY 2014 VL 174 IS 6 BP 988 EP 989 DI 10.1001/jamainternmed.2014.518 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA AI4OA UT WOS:000336843500038 PM 24710741 ER PT J AU Reis, G Ritter, J Bellini, W Bollen, A AF Reis, Gerald Ritter, Jana Bellini, William Bollen, Andrew TI A 29-year-old Pregnant Woman with Worsening Left Hemiparesis, Encephalopathy, and Hemodynamic Instability: A Case of SSPE SO JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY LA English DT Meeting Abstract CT 90th Annual Meeting of the American-Association-of-Neuropathologists-Inc CY JUN 12-15, 2014 CL Portland, OR SP Amer Assoc Neuropathologists Inc C1 [Reis, Gerald; Bollen, Andrew] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Ritter, Jana; Bellini, William] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-3069 EI 1554-6578 J9 J NEUROPATH EXP NEUR JI J. Neuropathol. Exp. Neurol. PD JUN PY 2014 VL 73 IS 6 MA 66 BP 602 EP 603 PG 2 WC Clinical Neurology; Neurosciences; Pathology SC Neurosciences & Neurology; Pathology GA AI3AZ UT WOS:000336732100074 ER PT J AU Su, KC Vinters, H Khanlou, N Yong, W Wu, A Shieh, WJ Blau, D Muehlenbachs, A AF Su, Keng-Chih Vinters, Harry Khanlou, Negar Yong, William Wu, Annie Shieh, Wun-Ju Blau, Dianna Muehlenbachs, Atis TI Balamuthia Amoebic Encephalitis, Diagnostic Challenges from Surgical Pathology to Autopsy: A Case Report SO JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY LA English DT Meeting Abstract CT 90th Annual Meeting of the American-Association-of-Neuropathologists-Inc CY JUN 12-15, 2014 CL Portland, OR SP Amer Assoc Neuropathologists Inc C1 [Su, Keng-Chih; Vinters, Harry; Khanlou, Negar; Yong, William; Wu, Annie] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neuropathol, Los Angeles, CA 90095 USA. [Shieh, Wun-Ju; Blau, Dianna; Muehlenbachs, Atis] Ctr Dis Control & Prevent CDC, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-3069 EI 1554-6578 J9 J NEUROPATH EXP NEUR JI J. Neuropathol. Exp. Neurol. PD JUN PY 2014 VL 73 IS 6 MA 67 BP 603 EP 603 PG 1 WC Clinical Neurology; Neurosciences; Pathology SC Neurosciences & Neurology; Pathology GA AI3AZ UT WOS:000336732100077 ER PT J AU Fleischer, NL Melstrom, P Yard, E Brubaker, M Thomas, T AF Fleischer, N. L. Melstrom, P. Yard, E. Brubaker, M. Thomas, T. TI The epidemiology of falling-through-the-ice in Alaska, 1990-2010 SO JOURNAL OF PUBLIC HEALTH LA English DT Article DE morbidity and mortality; public health; social determinants ID CLIMATE-CHANGE; HEALTH AB Climate change has contributed to increasing temperatures, earlier snowmelts and thinning ice packs in the Arctic, where crossing frozen bodies of water is essential for transportation and subsistence living. In some Arctic communities, anecdotal reports indicate a growing belief that falling-through-the-ice (FTI) are increasing. The objective of this study was to describe the morbidity and mortality associated with unintentional FTIs in Alaska. We searched newspaper reports to identify FTI events from 1990 to 2010. We also used data from a trauma registry, occupational health and law enforcement registries and vital statistics to supplement the newspaper reports. Morbidity and mortality rates were calculated for Alaska Native (AN) people and all Alaskans. During the 21-year period, we identified 307 events, affecting at least 449 people. Events ranged from no morbidity to fatalities of five people. More than half of the events involved transportation by snow machine. Mortality rates were markedly higher for AN people than that for all Alaskans. We provide a numeric estimate of the importance of FTI events in Alaska. FTIs may represent an adverse health outcome related to climate changes in the Arctic, and may be particularly critical for vulnerable populations such as AN people. C1 [Fleischer, N. L.] Ctr Dis Control & Prevent, Epidem Intelligence Serv Assigned, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA. [Melstrom, P.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Yard, E.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA. [Brubaker, M.] Alaska Native Tribal Hlth Consortium, Ctr Climate & Hlth, Anchorage, AK 99508 USA. [Thomas, T.] Alaska Native Tribal Hlth Consortium, Anchorage, AK 99508 USA. RP Fleischer, NL (reprint author), Univ S Carolina, Dept Epidemiol & Biostat, Arnold Sch Publ Hlth, 800 Sumter St, Columbia, SC 29208 USA. EM nfleischer@sc.edu FU Health Studies Branch, National Center for Environmental Health, CDC FX This work was supported by funding from the Health Studies Branch, National Center for Environmental Health, CDC. NR 25 TC 3 Z9 3 U1 2 U2 7 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1741-3842 EI 1741-3850 J9 J PUBLIC HEALTH-UK JI J. Public Health PD JUN PY 2014 VL 36 IS 2 BP 235 EP 242 DI 10.1093/pubmed/fdt081 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AI7NB UT WOS:000337077300009 PM 23995713 ER PT J AU Levings, JL Gunn, JP AF Levings, Jessica Lee Gunn, Janelle Peralez TI The Imbalance of Sodium and Potassium Intake: Implications for Dietetic Practice SO JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS LA English DT Article ID STOP HYPERTENSION DIET; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; TRIALS; METAANALYSIS; PREVENTION; MORTALITY; CHILDREN; STROKE; ADULTS C1 [Levings, Jessica Lee; Gunn, Janelle Peralez] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. RP Levings, JL (reprint author), Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. NR 33 TC 2 Z9 2 U1 1 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 2212-2672 J9 J ACAD NUTR DIET JI J. Acad. Nutr. Diet. PD JUN PY 2014 VL 114 IS 6 BP 838 EP 841 DI 10.1016/j.jand.2014.02.015 PG 4 WC Nutrition & Dietetics SC Nutrition & Dietetics GA AI7LD UT WOS:000337071200003 PM 24742901 ER PT J AU Clarke, DK Nasar, F Chong, S Johnson, JE Coleman, JW Lee, M Witko, SE Kotash, CS Abdullah, R Megati, S Luckay, A Nowak, B Lackner, A Price, RE Little, P Kalyan, N Randolf, V Javadian, A Zamb, TJ Parks, CL Egan, MA Eldridge, J Hendry, M Udem, SA AF Clarke, David K. Nasar, Farooq Chong, Siew Johnson, J. Erik Coleman, John W. Lee, Margaret Witko, Susan E. Kotash, Cheryl S. Abdullah, Rashed Megati, Shakuntala Luckay, Amara Nowak, Becky Lackner, Andrew Price, Roger E. Little, Peter Kalyan, Narender Randolf, Valerie Javadian, Ali Zamb, Timothy J. Parks, Christopher L. Egan, Michael A. Eldridge, John Hendry, Michael Udem, Stephen A. TI Neurovirulence and Immunogenicity of Attenuated Recombinant Vesicular Stomatitis Viruses in Nonhuman Primates SO JOURNAL OF VIROLOGY LA English DT Article ID RESPIRATORY SYNCYTIAL VIRUS; TEMPERATURE-SENSITIVE MUTANTS; CENTRAL-NERVOUS-SYSTEM; MATRIX PROTEIN; GENE-EXPRESSION; VACCINIA VIRUS; MUMPS-VIRUS; IN-VIVO; PHLEBOTOMINE SANDFLIES; BOOST VACCINATION AB In previous work, a prototypic recombinant vesicular stomatitis virus Indiana serotype (rVSIV) vector expressing simian immunodeficiency virus (SIV) gag and human immunodeficiency virus type 1 (HIV-1) env antigens protected nonhuman primates (NHPs) from disease following challenge with an HIV-1/SIV recombinant (SHIV). However, when tested in a stringent NHP neurovirulence (NV) model, this vector was not adequately attenuated for clinical evaluation. For the work described here, the prototypic rVSIV vector was attenuated by combining specific G protein truncations with either N gene translocations or mutations (M33A and M51A) that ablate expression of subgenic M polypeptides, by incorporation of temperature-sensitive mutations in the N and L genes, and by deletion of the VSIV G gene to generate a replicon that is dependent on trans expression of G protein for in vitro propagation. When evaluated in a series of NHP NV studies, these attenuated rVSIV variants caused no clinical disease and demonstrated a very significant reduction in neuropathology compared to wild-type VSIV and the prototypic rVSIV vaccine vector. In spite of greatly increased in vivo attenuation, some of the rVSIV vectors elicited cell-mediated immune responses that were similar in magnitude to those induced by the much more virulent prototypic vector. These data demonstrate novel approaches to the rational attenuation of VSIV NV while retaining vector immunogenicity and have led to identification of an rVSIV N4CT1gag1 vaccine vector that has now successfully completed phase I clinical evaluation. C1 [Clarke, David K.; Nowak, Becky; Egan, Michael A.; Eldridge, John] Profectus Biosci, Tarrytown, NY 10591 USA. [Nasar, Farooq] Univ Texas Med Branch, Galveston, TX 77555 USA. [Chong, Siew; Johnson, J. Erik; Lee, Margaret; Witko, Susan E.; Kotash, Cheryl S.; Abdullah, Rashed; Megati, Shakuntala; Luckay, Amara; Kalyan, Narender; Randolf, Valerie; Javadian, Ali; Zamb, Timothy J.; Udem, Stephen A.] Pfizer Pharmaceut Inc, Pearl River, NY USA. [Coleman, John W.; Parks, Christopher L.] AIDS Vaccine Design & Dev Lab, Int AIDS Vaccine Initiat, Brooklyn, NY USA. [Lackner, Andrew] Tulane Univ, Tulane Natl Primate Res Ctr, New Orleans, LA 70118 USA. [Price, Roger E.] Vet Pathol Serv, Houston, TX USA. [Little, Peter] EPL Inc, Res Triangle Pk, NC USA. [Hendry, Michael] Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, Natl Ctr HIV Hepatitis STD & TB Prevent, Atlanta, GA USA. RP Clarke, DK (reprint author), Profectus Biosci, Tarrytown, NY 10591 USA. EM DClarke@profectusbiosciences.net FU HVDDT [HHSN272200800061C]; NIH FX This work was supported by HVDDT contract HHSN272200800061C, awarded by the NIH. NR 89 TC 7 Z9 7 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD JUN PY 2014 VL 88 IS 12 BP 6690 EP 6701 DI 10.1128/JVI.03441-13 PG 12 WC Virology SC Virology GA AI5HF UT WOS:000336895600015 PM 24696472 ER PT J AU Camp, KM Parisi, MA Acosta, PB Berry, GT Bilder, DA Blau, N Bodamer, OA Brosco, JP Brown, CS Burlina, AB Burton, BK Chang, CS Coates, PM Cunningham, AC Dobrowolski, SF Ferguson, JH Franklin, TD Frazier, DM Grange, DK Greene, CL Groft, SC Harding, CO Howell, RR Huntington, KL Hyatt-Knorr, HD Jevaji, IP Levy, HL Lichter-Konecki, U Lindegren, ML Lloyd-Puryear, MA Matalon, K MacDonald, A McPheeters, ML Mitchell, JJ Mofidi, S Moseley, KD Mueller, CM Mulberg, AE Nerurkar, LS Ogata, BN Pariser, AR Prasad, S Pridjian, G Rasmussen, SA Reddy, UM Rohr, FJ Singh, RH Sirrs, SM Stremer, SE Tagle, DA Thompson, SM Urv, TK Utz, JR van Spronsen, F Vockley, J Waisbren, SE Weglicki, LS White, DA Whitley, CB Wilfond, BS Yannicelli, S Young, JM AF Camp, Kathryn M. Parisi, Melissa A. Acosta, Phyllis B. Berry, Gerard. T. Bilder, Deborah A. Blau, Nenad Bodamer, Olaf A. Brosco, Jeffrey P. Brown, Christine S. Burlina, Alberto B. Burton, Barbara K. Chang, Christine S. Coates, Paul M. Cunningham, Amy C. Dobrowolski, Steven F. Ferguson, John H. Franklin, Thomas D. Frazier, Dianne M. Grange, Dorothy K. Greene, Carol L. Groft, Stephen C. Harding, Cary O. Howell, R. Rodney Huntington, Kathleen L. Hyatt-Knorr, Henrietta D. Jevaji, Indira P. Levy, Harvey L. Lichter-Konecki, Uta Lindegren, Mary Lou Lloyd-Puryear, Michele A. Matalon, Kimberlee MacDonald, Anita McPheeters, Melissa L. Mitchell, John J. Mofidi, Shideh Moseley, Kathryn D. Mueller, Christine M. Mulberg, Andrew E. Nerurkar, Lata S. Ogata, Beth N. Pariser, Anne R. Prasad, Suyash Pridjian, Gabriella Rasmussen, Sonja A. Reddy, Uma M. Rohr, Frances J. Singh, Rani H. Sirrs, Sandra M. Stremer, Stephanie E. Tagle, Danilo A. Thompson, Susan M. Urv, Tiina K. Utz, Jeanine R. van Spronsen, Francjan Vockley, Jerry Waisbren, Susan E. Weglicki, Linda S. White, Desiree A. Whitley, Chester B. Wilfond, Benjamin S. Yannicelli, Steven Young, Justin M. TI Phenylketonuria Scientific Review Conference: State of the science and future research needs SO MOLECULAR GENETICS AND METABOLISM LA English DT Article DE Phenylketonuria; Sapropterin; Hyperphenylalaninemia; Maternal PIN; Large neutral amino acids; Glycomacropeptide ID PHENYLALANINE-HYDROXYLASE DEFICIENCY; NEUTRAL AMINO-ACIDS; DIHYDROPTERIDINE REDUCTASE DEFICIENCY; CONTINUOUSLY TREATED PHENYLKETONURIA; TETRAHYDROBIOPTERIN LOADING TEST; GENOTYPE-PHENOTYPE CORRELATIONS; THERAPEUTIC LIVER REPOPULATION; MATERNAL BLOOD PHENYLALANINE; ENZYME REPLACEMENT THERAPY; TANDEM MASS-SPECTROMETRY AB New developments in the treatment and management of phenylketonuria (PKU) as well as advances in molecular testing have emerged since the National Institutes of Health 2000 PKU Consensus Statement was released. An NIH State-of-the-Science Conference was convened in 2012 to address new findings, particularly the use of the medication sapropterin to treat some individuals with PKU, and to develop a research agenda. Prior to the 2012 conference, five working groups of experts and public members met over a 1-year period. The working groups addressed the following: long-term outcomes and management across the lifespan; PKU and pregnancy; diet control and management; pharmacologic interventions; and molecular testing, new technologies, and epidemiologic considerations. In a parallel and independent activity, an Evidence-based Practice Center supported by the Agency for Healthcare Research and Quality conducted a systematic review of adjuvant treatments for PKU; its conclusions were presented at the conference. The conference included the findings of the working groups, panel discussions from industry and international perspectives, and presentations on topics such as emerging treatments for PKU, transitioning to adult care, and the U.S. Food and Drug Administration regulatory perspective. Over 85 experts participated in the conference through information gathering and/or as presenters during the conference, and they reached several important conclusions. The most serious neurological impairments in PKU are preventable with current dietary treatment approaches. However, a variety of more subtle physical, cognitive, and behavioral consequences of even well-controlled PKU are now recognized. The best outcomes in maternal PKU occur when blood phenylalanine (Phe) concentrations are maintained between 120 and 360 Rtnol/L before and during pregnancy. The dietary management treatment goal for individuals with PKU is a blood Phe concentration between 120 and 360 [tmol/L. The use of genotype information in the newborn period may yield valuable insights about the severity of the condition for infants diagnosed before maximal Phe levels are achieved. While emerging and established genotype-phenotype correlations may transform our understanding of PKU, establishing correlations with intellectual outcomes is more challenging. Regarding the use of sapropterin in PKU, there are significant gaps in predicting response to treatment; at least half of those with PKU will have either minimal or no response. A coordinated approach to PKU treatment improves long-term outcomes for those with PKU and facilitates the conduct of research to improve diagnosis and treatment. New drugs that are safe, efficacious, and impact a larger proportion of individuals with PKU are needed. However, it is imperative that treatment guidelines and the decision processes for determining access to treatments be tied to a solid evidence base with rigorous standards for robust and consistent data collection. The process that preceded the PKU State-of-the-Science Conference, the conference itself, and the identification of a research agenda have facilitated the development of clinical practice guidelines by professional organizations and serve as a model for other inborn errors of metabolism. C1 [Camp, Kathryn M.; Coates, Paul M.; Lloyd-Puryear, Michele A.] NIH, Off Dietary Supplements, Bethesda, MD 20982 USA. [Parisi, Melissa A.; Reddy, Uma M.; Urv, Tiina K.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD 20892 USA. [Acosta, Phyllis B.; Singh, Rani H.] Emory Univ, Atlanta, GA 30033 USA. [Berry, Gerard. T.; Levy, Harvey L.; Waisbren, Susan E.] Harvard Univ, Boston Childrens Hosp, Sch Med, Boston, MA 02115 USA. [Bilder, Deborah A.] Univ Utah, Dept Psychiat, Salt Lake City, UT 84108 USA. [Blau, Nenad] Univ Childrens Hosp, Heidelberg, Germany. [Blau, Nenad] Univ Childrens Hosp, Zurich, Switzerland. [Bodamer, Olaf A.; Howell, R. Rodney] Univ Miami, Miller Sch Med, Miami, FL 33136 USA. [Brosco, Jeffrey P.] Univ Miami, Mailman Ctr Child Dev, Miami, FL 33101 USA. [Brown, Christine S.; Franklin, Thomas D.] Natl PKU Alliance, Encinitas, CA USA. [Burlina, Alberto B.] Univ Hosp, I-35128 Padua, Italy. [Burton, Barbara K.] Ann & Robert H Lurie Childrens Hosp Chicago, Chicago, IL 60611 USA. [Chang, Christine S.] Agcy Healthcare Res & Qual, Rockville, MD 20850 USA. [Cunningham, Amy C.; Pridjian, Gabriella] Tulane Univ, Sch Med, Hayward Genet Ctr, New Orleans, LA 70112 USA. [Dobrowolski, Steven F.; Vockley, Jerry] Univ Pittsburgh, Pittsburgh, PA 15224 USA. [Ferguson, John H.; Groft, Stephen C.; Hyatt-Knorr, Henrietta D.; Nerurkar, Lata S.] NIH, Off Rare Dis Res, Natl Ctr Adv Translat Sci, Bethesda, MD 20982 USA. [Frazier, Dianne M.] Univ N Carolina, Chapel Hill, NC 27599 USA. [Grange, Dorothy K.] Washington Univ, St Louis Childrens Hosp, Sch Med, St Louis, MO 63110 USA. [Greene, Carol L.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA. [Harding, Cary O.; Huntington, Kathleen L.] Oregon Hlth & Sci Univ, Portland, OR 97239 USA. [Jevaji, Indira P.] NIH, Off Res Womens Hlth, Bethesda, MD 20817 USA. [Lichter-Konecki, Uta] George Washington Univ, Childrens Natl Med Ctr, Washington, DC 20010 USA. [Lindegren, Mary Lou] Vanderbilt Univ, Sch Med, Nashville, TN 37203 USA. [Matalon, Kimberlee] Univ Houston, Houston, TX 77204 USA. [MacDonald, Anita] Birmingham Childrens Hosp, Birmingham B4 6NH, W Midlands, England. [McPheeters, Melissa L.] Inst Med & Publ Hlth, Vanderbilt Evidence Based Practice Ctr, Nashville, TN 37203 USA. [Mitchell, John J.] McGill Univ, Ctr Hlth, Montreal, PQ H3H 1P3, Canada. [Mofidi, Shideh] Maria Fareri Childrens Hosp, Westchester Med Ctr, Valhalla, NY 10595 USA. [Moseley, Kathryn D.] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA. [Mueller, Christine M.] US FDA, Off Orphan Prod Dev, Silver Spring, MD 20993 USA. [Mulberg, Andrew E.; Pariser, Anne R.] US FDA, Ctr Drug Evaluat & Res, Silver Spring, MD 20993 USA. [Ogata, Beth N.] Univ Washington, Seattle, WA 98195 USA. [Prasad, Suyash] BioMarin Pharmaceut Inc, San Rafael, CA 94901 USA. [Rasmussen, Sonja A.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Rohr, Frances J.] Boston Childrens Hosp, Boston, MA 02115 USA. [Sirrs, Sandra M.] Univ British Columbia, Vancouver Gen Hosp, Vancouver, BC V5Z 1M9, Canada. [Burlina, Alberto B.] PKU & Allied Disorders Wisconsin, Madison, WI 53705 USA. [Tagle, Danilo A.] NIH, Natl Ctr Adv Translat Sci, Bethesda, MD 20892 USA. [Thompson, Susan M.] Childrens Hosp Westrnead, Sydney, NSW 2145, Australia. [Utz, Jeanine R.; Whitley, Chester B.] Univ Minnesota, Minneapolis, MN 55455 USA. [van Spronsen, Francjan] Univ Groningen, Univ Med Ctr Groningen, Beatrix Childrens Hosp, NL-9700 AB Groningen, Netherlands. [Weglicki, Linda S.] NINR, NIH, Bethesda, MD 20892 USA. [White, Desiree A.] Washington Univ, Dept Psychol, St Louis, MO 63130 USA. [Wilfond, Benjamin S.] Univ Washington, Seattle Childrens Res Inst, Sch Med, Seattle, WA 98101 USA. [Yannicelli, Steven] Nutricia North Amer, Rockville, MD 20850 USA. [Young, Justin M.] Young Face Facial Plast & Reconstruct Surg, Cumming, GA 30041 USA. RP Camp, KM (reprint author), 6100 Execut Blvd, Rockville, MD 20892 USA. EM campkm@od.nih.gov; parisima@mail.nih.gov; pja1933@gmail.com; gerard.berry@childrens.harvard.edu; deborah.bilder@hsc.utah.edu; nenad.blau@med.uni-heidelberg.de; obodamer@med.miami.edu; jbrosco@med.miami.edu; christine.brown@npkua.org; alberto.burlina@unipd.it; bburton@luriechildrens.org; christine.chang@ahrq.hhs.gov; coatesp@od.nih.gov; acunnin@tulane.edu; dobrowolskis@upmc.edu; jferg@helix.nih.gov; tom.franklin@npkua.org; dianne_frazier@med.unc.edu; grange_d@kids.wustl.edu; cgreene@peds.umaryland.edu; stephen.groft@nih.gov; hardingc@ohsu.edu; rhowell@miami.edu; huntingt@ohsu.edu; henrietta.hyatt-knorr@nih.gov; indira.jevaji@cms.hhs.gov; harvey.levy@childrens.harvard.edu; ulichter@cnmc.org; marylou.lindegren@vanderbilt.edu; lloydpuryearma@od.nih.gov; kmatalon@uh.edu; anita.macdonald@bch.nhs.uk; melissa.mcpheeters@vanderbilt.edu; john.mitchell@muhc.mcgill.ca; shideh_mofidi@nymc.edu; kmoseley@usc.edu; christine.mueller@nih.gov; andrew.mulberg@fda.hhs.gov; lnerurkar@gmail.com; bogata@uw.edu; anne.pariser@fda.hhs.gov; sprasad@bmrn.com; pridjian@tulane.edu; skr9@cdc.gov; reddyu@mail.nih.gov; frances.rohr@childrens.harvard.edu; rsingh@emory.edu; sandra.sirrs@vch.ca; sstremer@yahoo.com; danilo.tagle@nih.gov; sue.thompson@health.nsw.gov.au; urvtiin@mail.nih.gov; jutz1@fairview.org; f.j.van.spronsen@umcg.nl; vockleyg@upmc.edu; susan.waisbren@childrens.harvard.edu; weglickils@mail.nih.gov; dawhite@wustl.edu; whitley@umn.edu; benjamin.wilfond@seattlechildrens.org; steven.yannicelli@nutricia.com; jmichaelyoung@yahoo.com OI Berry, Gerard/0000-0001-5299-3313; Vockley, Jerry/0000-0002-8180-6457 NR 336 TC 43 Z9 43 U1 5 U2 73 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1096-7192 EI 1096-7206 J9 MOL GENET METAB JI Mol. Genet. Metab. PD JUN PY 2014 VL 112 IS 2 BP 87 EP 122 DI 10.1016/j.ymgme.2014.02.013 PG 36 WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research & Experimental SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental Medicine GA AI7KF UT WOS:000337067900002 PM 24667081 ER PT J AU Goldstein, BD Brooks, BW Cohen, SD Gates, AE Honeycutt, ME Morris, JB Orme-Zavaleta, J Penning, TM Snawder, J AF Goldstein, Bernard D. Brooks, Bryan W. Cohen, Steven D. Gates, Alexander E. Honeycutt, Michael E. Morris, John B. Orme-Zavaleta, Jennifer Penning, Trevor M. Snawder, John TI The Role of Toxicological Science in Meeting the Challenges and Opportunities of Hydraulic Fracturing SO TOXICOLOGICAL SCIENCES LA English DT Editorial Material DE hydraulic fracturing; mixtures; shale gas; methane; benzene; radon ID RATIONAL MOLECULAR DESIGN; MARCELLUS SHALE REGION; NATURAL-GAS EXTRACTION; DRINKING-WATER WELLS; METHANE CONTAMINATION; AQUATIC TOXICITY; RISK-ASSESSMENT; WASTE-WATER; IMPACTS; PENNSYLVANIA AB We briefly describe how toxicology can inform the discussion and debate of the merits of hydraulic fracturing by providing information on the potential toxicity of the chemical and physical agents associated with this process, individually and in combination. We consider upstream activities related to bringing chemical and physical agents to the site, on-site activities including drilling of wells and containment of agents injected into or produced from the well, and downstream activities including the flow/removal of hydrocarbon products and of produced water from the site. A broad variety of chemical and physical agents are involved. As the industry expands this has raised concern about the potential for toxicological effects on ecosystems, workers, and the general public. Response to these concerns requires a concerted and collaborative toxicological assessment. This assessment should take into account the different geology in areas newly subjected to hydraulic fracturing as well as evolving industrial practices that can alter the chemical and physical agents of toxicological interest. The potential for ecosystem or human exposure to mixtures of these agents presents a particular toxicological and public health challenge. These data are essential for developing a reliable assessment of the potential risks to the environment and to human health of the rapidly increasing use of hydraulic fracturing and deep underground horizontal drilling techniques for tightly bound shale gas and other fossil fuels. Input from toxicologists will be most effective when employed early in the process, before there are unwanted consequences to the environment and human health, or economic losses due to the need to abandon or rework costly initiatives. C1 [Goldstein, Bernard D.] Univ Pittsburgh, Dept Environm & Occupat Hlth, Pittsburgh, PA 15261 USA. [Brooks, Bryan W.] Baylor Univ, Dept Environm Sci, Waco, TX 76798 USA. [Cohen, Steven D.] Massachusetts Coll Pharm & Hlth Sci, Sch Pharm Worcester Manchester, Worcester, MA 01608 USA. [Gates, Alexander E.] Rutgers State Univ, Dept Earth & Environm Sci, Newark, NJ 07102 USA. [Honeycutt, Michael E.] Texas Commiss Environm Qual, Div Toxicol, Austin, TX 78711 USA. [Morris, John B.] Univ Connecticut, Sch Pharm, Storrs, CT 06269 USA. [Orme-Zavaleta, Jennifer] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Penning, Trevor M.] Univ Penn, Dept Pharmacol, Philadelphia, PA 19104 USA. [Snawder, John] Natl Inst Occupat Safety & Hlth Appl Res & Techno, Ctr Dis Control & Prevent, Williamstown, KY 41097 USA. RP Goldstein, BD (reprint author), 130 DeSoto St,A710 Crabtree Hall, Pittsburgh, PA 15261 USA. EM bdgold@pitt.edu RI Brooks, Bryan/B-2612-2010; Guenat, Heather/H-6528-2014; OI Brooks, Bryan/0000-0002-6277-9852; Penning, Trevor/0000-0002-3937-1066 FU NIEHS NIH HHS [P30 ES013508, P30-ES013508] NR 66 TC 17 Z9 17 U1 3 U2 85 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD JUN PY 2014 VL 139 IS 2 BP 271 EP 283 DI 10.1093/toxsci/kfu061 PG 13 WC Toxicology SC Toxicology GA AI7MO UT WOS:000337075900001 PM 24706166 ER PT J AU Soucie, JM Miller, CH Kelly, FM Aschman, D DiMichele, D Konkle, BA Kulkarni, R Monahan, PE AF Soucie, J. Michael Miller, Connie H. Kelly, Fiona M. Aschman, Diane DiMichele, Donna Konkle, Barbara A. Kulkarni, Roshni Monahan, Paul E. CA CDC Inhibitor Surveillance Working TI National surveillance for hemophilia inhibitors in the United States: Summary report of an expert meeting SO AMERICAN JOURNAL OF HEMATOLOGY LA English DT Article ID FACTOR-VIII INHIBITORS; NIJMEGEN MODIFICATION; BETHESDA ASSAY; IX INHIBITORS; C INHIBITORS; POPULATION; DIAGNOSIS; KINGDOM AB On March 12, 2012, the Centers for Disease Control and Prevention (CDC) held a meeting of its partners in hemophilia treatment, community-based organizations, industry, and government to review data and discuss implementation issues relevant to planned United States (U.S.) national inhibitor surveillance. Issues discussed included the current status of inhibitor surveillance in the United Kingdom (UK) and the US, the results of a US inhibitor surveillance feasibility study, proposed national surveillance schemes, laboratory testing and reporting issues and potential opportunities for future inhibitor-related research. It was concluded that implementation of a national program of inhibitor surveillance using standardized testing through an established public health registry along with patient and care provider education and targeted research provide the best opportunity to inform efforts to develop and evaluate effective prevention strategies.Am. J. Hematol. 89:621-625, 2014. (c) 2014 Wiley Periodicals, Inc. C1 [Soucie, J. Michael; Miller, Connie H.; Kelly, Fiona M.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Div Blood Disorders, Atlanta, GA USA. [Aschman, Diane] Amer Thrombosis & Hemostasis Network, Chicago, IL USA. [DiMichele, Donna] NHLBI, NIH, Bethesda, MD 20892 USA. [Konkle, Barbara A.] Puget Sound Blood Ctr, Seattle, WA 98104 USA. [Kulkarni, Roshni] Michigan State Univ, Dept Pediat & Human Dev, E Lansing, MI 48824 USA. [Monahan, Paul E.] Univ N Carolina, Dept Pediat, Div Hematol Oncol, Chapel Hill, NC USA. RP Soucie, JM (reprint author), Div Blood Disorders, 1600 Clifton Rd,MS E64, Atlanta, GA 30333 USA. EM msoucie@cdc.gov OI Miller, Connie H/0000-0002-3989-7973 FU Intramural CDC HHS [CC999999] NR 15 TC 2 Z9 2 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0361-8609 EI 1096-8652 J9 AM J HEMATOL JI Am. J. Hematol. PD JUN PY 2014 VL 89 IS 6 BP 621 EP 625 DI 10.1002/ajh.23704 PG 5 WC Hematology SC Hematology GA AI1NU UT WOS:000336618600212 PM 24616187 ER PT J AU Grosse, SD Presley, RJ Yusuf, HR Richardson, LC Amin, A AF Grosse, Scott D. Presley, Rodney J. Yusuf, Hussain R. Richardson, Lisa C. Amin, Alpesh TI INCREASED USE OF ANTICOAGULANT THROMBOPROPHYLAXIS IN US HOSPITALS, 2006-2010 SO AMERICAN JOURNAL OF HEMATOLOGY LA English DT Meeting Abstract C1 [Grosse, Scott D.; Presley, Rodney J.; Yusuf, Hussain R.; Richardson, Lisa C.] Ctr Dis Control & Prevent, Div Blood Disorders, Atlanta, GA USA. [Amin, Alpesh] Univ Calif Irvine, Dept Med, Irvine, CA 92717 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0361-8609 EI 1096-8652 J9 AM J HEMATOL JI Am. J. Hematol. PD JUN PY 2014 VL 89 IS 6 MA 4 BP E2 EP + PG 2 WC Hematology SC Hematology GA AI1NU UT WOS:000336618600005 ER PT J AU Manco-Johnson, MJ Dudley, B Recht, M Byams, V Kapica, S Aschman, D Cooke, B Oakley, M AF Manco-Johnson, Marilyn J. Dudley, Becky Recht, Michael Byams, Vanessa Kapica, Suzanne Aschman, Diane Cooke, Brandi Oakley, Michele TI COMMUNITY COUNTS: A NATIONAL SURVEILLANCE SYSTEM FOR BLEEDING AND CLOTTING DISORDERS SO AMERICAN JOURNAL OF HEMATOLOGY LA English DT Meeting Abstract C1 [Manco-Johnson, Marilyn J.] Univ Colorado, Aurora, CO USA. [Dudley, Becky; Aschman, Diane] Amer Thrombosis & Hemostasis Network, Greenrivers, IL USA. [Recht, Michael] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Byams, Vanessa; Cooke, Brandi; Oakley, Michele] Ctr Dis Control & Prevent, Atlanta, GA USA. [Kapica, Suzanne] Hemophilia Fdn Michigan, Ypsilanti, MI USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0361-8609 EI 1096-8652 J9 AM J HEMATOL JI Am. J. Hematol. PD JUN PY 2014 VL 89 IS 6 MA 7 BP E4 EP E4 PG 1 WC Hematology SC Hematology GA AI1NU UT WOS:000336618600008 ER PT J AU Soucie, JM Grosse, SD Siddiqi, AEA Byams, V Thierry, J Zack, M Shapiro, A Duncan, N AF Soucie, J. Michael Grosse, Scott D. Siddiqi, Azfar-E-Alam Byams, Vanessa Thierry, JoAnn Zack, Matthew Shapiro, Amy Duncan, Natalie TI DETERMINANTS OF HEALTH-RELATED QUALITY OF LIFE AMONG PERSONS WITH SEVERE HEMOPHILIA A IN THE UNITED STATES SO AMERICAN JOURNAL OF HEMATOLOGY LA English DT Meeting Abstract C1 [Soucie, J. Michael; Grosse, Scott D.; Siddiqi, Azfar-E-Alam; Byams, Vanessa; Thierry, JoAnn; Zack, Matthew] Ctr Dis Control & Prevent, Atlanta, GA USA. [Shapiro, Amy; Duncan, Natalie] Indiana Hemophilia & Thrombosis Ctr, Indianapolis, IN USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0361-8609 EI 1096-8652 J9 AM J HEMATOL JI Am. J. Hematol. PD JUN PY 2014 VL 89 IS 6 MA 100 BP E48 EP E48 PG 1 WC Hematology SC Hematology GA AI1NU UT WOS:000336618600098 ER PT J AU Lo, MK Nichol, ST Spiropoulou, CF AF Lo, Michael K. Nichol, Stuart T. Spiropoulou, Christina F. TI Evaluation of luciferase and GFP-expressing Nipah viruses for rapid quantitative antiviral screening SO ANTIVIRAL RESEARCH LA English DT Article DE Henipavirus; Nipah virus; Antiviral screening; Luciferase; GFP; High-throughput screening ID INFECTION; HENDRA; ESTABLISHMENT; REPLICATION; INHIBITION; INTERFERON; VALIDATION; GENERATION; CELLS; GENE AB Nipah virus (NiV) outbreaks have occurred in Malaysia, India, and Bangladesh, and the virus continues to cause annual outbreaks of fatal human encephalitis in Bangladesh due to spillover from its bat host reservoir. Due to its high pathogenicity, its potential use for bio/agro-terrorism, and to the current lack of approved therapeutics, NiV is designated as an overlap select agent requiring biosafety level-4 containment. Although the development of therapeutic monoclonal antibodies and soluble protein subunit vaccines have shown great promise, the paucity of effective antiviral drugs against NiV merits further exploration of compound libraries using rapid quantitative antiviral assays. As a proof-of-concept study, we evaluated the use of fluorescent and luminescent reporter NiVs for antiviral screening. We constructed and rescued NiVs expressing either Renilla luciferase or green fluorescent protein, and characterized their reporter signal kinetics in different cell types as well as in the presence of several inhibitors. The 50% effective concentrations (EC(50)s) derived for inhibitors against both reporter viruses are within range of EC50s derived from virus yield-based dose-response assays against wild-type NiV (within 1 Log(10)), thus demonstrating that both reporter NiVs can serve as robust antiviral screening tools. Utilizing these live NiV-based reporter assays requires modest instrumentation, and circumvents the time and labor-intensive steps associated with cytopathic effect or viral antigen-based assays. These reporter NiVs will not only facilitate antiviral screening, but also the study of host cell components that influence the virus life cycle. Published by Elsevier B.V. C1 [Lo, Michael K.; Nichol, Stuart T.; Spiropoulou, Christina F.] Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Atlanta, GA 30333 USA. RP Lo, MK (reprint author), Ctr Dis Control & Prevent, Viral Special Pathogens Branch, 1600 Clifton Rd,Mailstop G-14, Atlanta, GA 30333 USA. EM mko2@cdc.gov; ccs8@cdc.gov OI Lo, Michael/0000-0002-0409-7896 FU Intramural CDC HHS [CC999999] NR 31 TC 8 Z9 8 U1 0 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 EI 1872-9096 J9 ANTIVIR RES JI Antiviral Res. PD JUN PY 2014 VL 106 BP 53 EP 60 DI 10.1016/j.antiviral.2014.03.011 PG 8 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA AI4IA UT WOS:000336827700007 PM 24680955 ER PT J AU Uebelhoer, LS Albarino, CG McMullan, LK Chakrabarti, AK Vincent, JP Nichol, ST Towner, JS AF Uebelhoer, Luke S. Albarino, Cesar G. McMullan, Laura K. Chakrabarti, Ayan K. Vincent, Joel P. Nichol, Stuart T. Towner, Jonathan S. TI High-throughput, luciferase-based reverse genetics systems for identifying inhibitors of Marburg and Ebola viruses SO ANTIVIRAL RESEARCH LA English DT Article DE Filovirus; Marburg virus; Ebola virus; Luciferase; Reverse genetics; Antiviral screen ID SPECTRUM ANTIVIRAL ACTIVITY; HEMORRHAGIC FEVERS; RNA INTERFERENCE; IN-VITRO; REPLICATION; TRANSCRIPTION; PROTEIN; IDENTIFICATION; INFECTION; VP35 AB Marburg virus (MARV) and Ebola virus (EBOV), members of the family Filoviridae, represent a significant challenge to global public health. Currently, no licensed therapies exist to treat filovirus infections, which cause up to 90% mortality in human cases. To facilitate development of antivirals against these viruses, we established two distinct screening platforms based on MARV and EBOV reverse genetics systems that express secreted Gaussia luciferase (gLuc). The first platform is a mini-genome replicon to screen viral replication inhibitors using gLuc quantification in a BSL-2 setting. The second platform is complementary to the first and expresses gLuc as a reporter gene product encoded in recombinant infectious MARV and EBOV, thereby allowing for rapid quantification of viral growth during treatment with antiviral compounds. We characterized these viruses by comparing luciferase activity to virus production, and validated luciferase activity as an authentic real-time measure of viral growth. As proof of concept, we adapt both mini-genome and infectious virus platforms to high-throughput formats, and demonstrate efficacy of several antiviral compounds. We anticipate that both approaches will prove highly useful in the development of anti-filovirus therapies, as well as in basic research on the filovirus life cycle. Published by Elsevier B.V. C1 [Uebelhoer, Luke S.; Albarino, Cesar G.; McMullan, Laura K.; Chakrabarti, Ayan K.; Vincent, Joel P.; Nichol, Stuart T.; Towner, Jonathan S.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Towner, JS (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. EM jit8@cdc.gov FU Research Participation Program at the Centers for Disease Control and Prevention (CDC); Centers for Disease Control and Prevention (CDC) FX The authors would like to thank Karl-Klaus Conzelmann (Max-von-Pettenkofer-Institut, Munich, Germany) for providing BSR-T7/5 cells, Marina Khristova for assistance with genome sequencing of clones, Tatyana Klimova for critical editing of the manuscript, and Michael Flint for providing inhibitory compounds and excellent technical advice. Luke Uebelhoer holds a fellowship supported by the Research Participation Program at the Centers for Disease Control and Prevention (CDC) administered by the Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement between the U.S. Department of Energy (DOE) and CDC. NR 40 TC 29 Z9 32 U1 3 U2 44 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 EI 1872-9096 J9 ANTIVIR RES JI Antiviral Res. PD JUN PY 2014 VL 106 BP 86 EP 94 DI 10.1016/j.antiviral.2014.03.018 PG 9 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA AI4IA UT WOS:000336827700011 PM 24713118 ER PT J AU Lee, S Ward, TJ Graves, LM Tarr, CL Siletzky, RM Kathariou, S AF Lee, Sangmi Ward, Todd J. Graves, Lewis M. Tarr, Cheryl L. Siletzky, Robin M. Kathariou, Sophia TI Population Structure of Listeria monocytogenes Serotype 4b Isolates from Sporadic Human Listeriosis Cases in the United States from 2003 to 2008 SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID BENZALKONIUM CHLORIDE RESISTANCE; MULTILOCUS GENOTYPING ASSAY; FIELD GEL-ELECTROPHORESIS; TURKEY-PROCESSING PLANTS; GENETIC-CHARACTERIZATION; EPIDEMIC CLONES; HEAVY-METAL; FOOD SAFETY; STRAINS; OUTBREAK AB Listeria monocytogenes can cause severe food-borne disease (listeriosis). Numerous outbreaks have involved three serotype 4b epidemic clones (ECs): ECI, ECII, and ECIa. However, little is known about the population structure of L. monocytogenes serotype 4b from sporadic listeriosis in the United States, even though most cases of human listeriosis are in fact sporadic. Here we analyzed 136 serotype 4b isolates from sporadic cases in the United States, 2003 to 2008, utilizing multiple tools including multilocus genotyping, pulsed-field gel electrophoresis, and sequence analysis of the inlAB locus. ECI, ECII, and ECIa were frequently encountered (32, 17, and 7%, respectively). However, annually 30 to 68% of isolates were outside these ECs, and several novel clonal groups were identified. An estimated 33 and 17% of the isolates, mostly among the ECs, were resistant to cadmium and arsenic, respectively, but resistance to benzalkonium chloride was uncommon (3%) among the sporadic isolates. The frequency of clonal groups fluctuated within the 6-year study period, without consistent trends. However, on several occasions, temporal clusters of isolates with indistinguishable genotypes were detected, suggesting the possibility of hidden multistate outbreaks. Our analysis suggests a complex population structure of serotype 4b L. monocytogenes from sporadic disease, with important contributions by ECs and several novel clonal groups. Continuous monitoring will be needed to assess long-term trends in clonality patterns and population structure of L. monocytogenes from sporadic listeriosis. C1 [Lee, Sangmi; Siletzky, Robin M.; Kathariou, Sophia] N Carolina State Univ, Dept Food Bioproc & Nutr Sci, Raleigh, NC 27695 USA. [Ward, Todd J.] ARS, Bacterial Foodborne Pathogens & Mycol Res Unit, USDA, Peoria, IL USA. [Graves, Lewis M.; Tarr, Cheryl L.] Ctr Dis Control & Prevent, Enter Dis Lab Branch, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. RP Lee, S (reprint author), N Carolina State Univ, Dept Food Bioproc & Nutr Sci, Raleigh, NC 27695 USA. EM slee19@ncsu.edu FU USDA [2006-35201-17377]; U.S. Department of Agriculture's Agricultural Research Service FX This study was partially supported by USDA grant 2006-35201-17377 and the U.S. Department of Agriculture's Agricultural Research Service. NR 47 TC 5 Z9 5 U1 0 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 EI 1098-5336 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD JUN PY 2014 VL 80 IS 12 BP 3632 EP 3644 DI 10.1128/AEM.00454-14 PG 13 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA AI3EX UT WOS:000336744000010 PM 24705322 ER PT J AU Campo, DS Skums, P Dimitrova, Z Vaughan, G Forbi, JC Teol, CG Khudyakov, Y Lau, DTY AF Campo, D. S. Skums, P. Dimitrova, Z. Vaughan, G. Forbi, J. C. Teol, C. G. Khudyakov, Y. Lau, D. T-Y TI Drug Resistance of a Viral Population and Its Individual Intrahost Variants During the First 48 Hours of Therapy SO CLINICAL PHARMACOLOGY & THERAPEUTICS LA English DT Article ID CHRONIC HEPATITIS-C; ANTIVIRAL TREATMENT; INTERFERON; RIBAVIRIN; VIRUS; PHYLOGENIES; INFECTION AB Using hepatitis C virus (HCV) and interferon (IFN) resistance as a Proof of concept, we have devised a new method for calculating the effect of a drug on a viral population, as well as the resistance of the population's individual intrahost variants. By means of next-generation sequencing, HCV variants were obtained from sera collected at nine time points from 16 patients during the first 48h after injection of IFN-alpha. IFN-resistance coefficients were calculated for individual variants using changes in their relative frequencies, and for the entire intrahost viral population using changes in viral titer. Population-wide resistance and presence of IFN-resistant variants were highly associated with pegylated IFN-alpha 2a/ribavirin treatment outcome at week 12 (P = 3.78 x 10(-5) and 0.0114, respectively). This new method allows an accurate measurement of resistance based solely on changes in viral titer or the relative frequency of intrahost viral variants during a short observation time. C1 [Campo, D. S.; Skums, P.; Dimitrova, Z.; Vaughan, G.; Forbi, J. C.; Teol, C. G.; Khudyakov, Y.] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30333 USA. [Lau, D. T-Y] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Liver Ctr,Div Gastroenterol, Boston, MA 02215 USA. RP Campo, DS (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30333 USA. EM fyv6@cdc.gov OI Campo, David S./0000-0002-8970-3436 FU National Institutes of Health [R01 DK068598-01, M01-RR-01032] FX This study was supported by National Institutes of Health grants R01 DK068598-01 (to D.T.-Y.L.), M01-RR-01032, and M01-RR-01032 (to the General Clinical Research Center). NR 30 TC 4 Z9 5 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0009-9236 EI 1532-6535 J9 CLIN PHARMACOL THER JI Clin. Pharmacol. Ther. PD JUN PY 2014 VL 95 IS 6 BP 627 EP 635 DI 10.1038/clpt.2014.20 PG 9 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA AH8VC UT WOS:000336415300026 PM 24488144 ER PT J AU Ford, ES Mannino, DM Giles, WH Wheaton, AG Liu, Y Croft, JB AF Ford, Earl S. Mannino, David M. Giles, Wayne H. Wheaton, Anne G. Liu, Yong Croft, Janet B. TI Prescription Practices for Chronic Obstructive Pulmonary Disease: Findings from the National Ambulatory Medical Care Survey 1999-2010 SO COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE LA English DT Article DE COPD; prescriptions; therapeutics; trends ID CLINICAL-PRACTICE GUIDELINE; AMERICAN-COLLEGE; TIOTROPIUM; EXACERBATIONS; EPIDEMIOLOGY; PREVENTION; PHYSICIANS; PROPIONATE; SALMETEROL; MANAGEMENT AB Recent trends in prescriptions for medicines used to treat chronic obstructive pulmonary disease (COPD) in the United States have received little attention. Our objective was to examine trends in prescribing practices for medications used to treat COPD. We examined data from surveys of national samples of office visits to non-federal employed office-based physicians in the United States by patients aged >= 40 years with COPD recorded by the National Ambulatory Medical Care Survey from 1999 to 2010. From three diagnostic codes, office visits by patients with COPD were identified. Prescribed medications were identified from up to 8 recorded medications. The percentage of these visits during which a prescription for any medication used to treat COPD was issued increased from 27.0% in 1999 to 49.1% in 2010 (p trend < 0.001). Strong increases were noted for short-acting beta-2 agonists (17.6% in 1999 to 24.7% in 2010; p trend < 0.001), long-acting beta-2 agonists as single agents or combination products (6.2% in 1999 to 28.3% in 2010; p trend < 0.001), inhaled corticosteroids as single agents or combination products (10.9% in 1999 to 30.9% in 2010; p trend < 0.001), and tiotropium (3.8% in 2004 to 17.2% in 2010; p trend < 0.001). Since 1999, prescription patterns for medicines used to treat COPD have changed profoundly in the United States. C1 [Ford, Earl S.; Giles, Wayne H.; Wheaton, Anne G.; Liu, Yong; Croft, Janet B.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Populat Hlth, Atlanta, GA 30341 USA. [Mannino, David M.] Univ Kentucky, Coll Publ Hlth, Dept Prevent Med & Environm Hlth, Lexington, KY USA. RP Ford, ES (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway,MS F78, Atlanta, GA 30341 USA. EM eford@cdc.gov OI Mannino, David/0000-0003-3646-7828 FU GlaxoSmithKline plc; Novartis Pharmaceuticals; Pfizer Inc.; AstraZeneca PLC; Forest Laboratories Inc.; Creative Educational Concepts FX Dr. Mannino has received honoraria/consulting fees and served on speaker bureaus for GlaxoSmithKline plc, Novartis Pharmaceuticals, Pfizer Inc., AstraZeneca PLC, Forest Laboratories Inc., and Creative Educational Concepts. Furthermore, he has received royalties from Up-to-Date. The other authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper. NR 20 TC 3 Z9 3 U1 0 U2 2 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1541-2555 EI 1541-2563 J9 COPD JI COPD-J. Chronic Obstr. Pulm. Dis. PD JUN PY 2014 VL 11 IS 3 BP 247 EP 255 DI 10.3109/15412555.2013.840570 PG 9 WC Respiratory System SC Respiratory System GA AI0AI UT WOS:000336507800002 PM 24568285 ER PT J AU Pleasants, RA Ohar, JA Croft, JB Liu, Y Kraft, M Mannino, DM Donohue, JF Herrick, HL AF Pleasants, Roy A. Ohar, Jill A. Croft, Janet B. Liu, Yong Kraft, Monica Mannino, David M. Donohue, James F. Herrick, Harry L. TI Chronic Obstructive Pulmonary Disease and Asthma - Patient Characteristics and Health Impairment SO COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE LA English DT Article DE chronic obstructive pulmonary disease; asthma; overlap syndrome; Behavioral Risk factor Surveillance System; health impairment ID QUALITY-OF-LIFE; UNITED-STATES; CARDIOVASCULAR-DISEASE; SOCIOECONOMIC-STATUS; COPD PATIENTS; PHYSICAL-ACTIVITY; GLOBAL BURDEN; RISK-FACTORS; POPULATION; PREVALENCE AB Background: Persons with chronic obstructive pulmonary disease (COPD) and/or asthma have great risk for morbidity. There has been sparse state-specific surveillance data to estimate the impact of COPD or COPD with concomitant asthma (overlap syndrome) on health-related impairment. Methods: The North Carolina (NC) Behavioral Risk Factor Surveillance System (BRFSS) was used to assess relationships between COPD and asthma with health impairment indicators. Five categories [COPD, current asthma, former asthma, overlap syndrome, and neither] were defined for 24,073 respondents. Associations of these categories with health impairments (physical or mental disability, use of special equipment, mental or physical distress) and with co-morbidities (diabetes, coronary heart disease, stroke, arthritis, and high blood pressure) were assessed. Results: Fifteen percent of NC adults reported a COPD and/or asthma history. The overall age-adjusted prevalence of any self-reported COPD and current asthma were 5.6% and 7.6%, respectively; 2.4% reported both. In multivariable analyses, adults with overlap syndrome, current asthma only, and COPD only were twice as likely as those with neither disease to report health impairments (p < 0.05). Compared to those with neither disease, adults with overlap syndrome and COPD were more likely to have co-morbidities (p < 0.05). The prevalence of the five co-morbid conditions was highest in overlap syndrome; comparisons with the other groups were significant (p < 0.05) only for diabetes, stroke, and arthritis. Conclusions: The BRFSS demonstrates different levels of health impairment among persons with COPD, asthma, overlap syndrome, and those with neither disease. Persons reporting overlap syndrome had the most impairment and highest prevalence of co-morbidities. C1 [Pleasants, Roy A.] Campbell Univ, Coll Pharm & Hlth Sci, Durham, NC USA. [Pleasants, Roy A.] Duke Univ, Sch Med, Div Pulm Allergy & Crit Care Med, Durham, NC 27710 USA. [Ohar, Jill A.] Wake Forest Univ, Sch Med, Sect Pulm Crit Care Allergy & Immunol Dis, Winston Salem, NC 27109 USA. [Croft, Janet B.; Liu, Yong] Ctr Dis Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Populat Hlth, Atlanta, GA 30333 USA. [Kraft, Monica] Duke Univ, Sch Med, Div Pulm Allergy & Crit Care Med, Durham, NC 27710 USA. [Mannino, David M.] Univ Kentucky, Pulm Epidemiol Res Lab, Div Pulm Crit Care & Sleep Med, Lexington, KY USA. [Donohue, James F.] Univ N Carolina, Dept Med, Div Pulm Dis & Crit Care, Chapel Hill, NC USA. [Herrick, Harry L.] North Carolina Div Publ Hlth, State Ctr Hlth Stat, Raleigh, NC USA. RP Pleasants, RA (reprint author), Duke Univ, Duke Univ Hosp, Div Pulm Allergy & Crit Care Med, Durham, NC 27710 USA. EM roy.pleasants@duke.edu OI Mannino, David/0000-0003-3646-7828 FU National Institutes of Health; Genentech; GlaxoSmithKline; Merck; Asthmatx (Boston Scientific); Eumedics; Novartis; American thoracic Society for leadership role; Research Grant Aerocrine FX The authors report the following: RAP: Speaker for Astra Zeneca, Boehringer Ingelheim, Novartis, Pfizer: JOA: Advisory Board for Astra Zeneca and Glaxo Smith Kline; JBC: No conflicts of interest; YL: No conflicts of interest; MK: Research Grants: National Institutes of Health, Genentech, GlaxoSmithKline, Merck, Asthmatx (Boston Scientific), Eumedics, and Novartis. Stipend from American thoracic Society for leadership role; JFD: Consultant/advisor: Glaxo Smith Kline, Boehringer Ingelheim, Forest, Novartis, Mylan, and Sunovion. Research Grant Aerocrine; and HLK: No conflicts of interest. NR 53 TC 24 Z9 25 U1 1 U2 6 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1541-2555 EI 1541-2563 J9 COPD JI COPD-J. Chronic Obstr. Pulm. Dis. PD JUN PY 2014 VL 11 IS 3 BP 256 EP 266 DI 10.3109/15412555.2013.840571 PG 11 WC Respiratory System SC Respiratory System GA AI0AI UT WOS:000336507800003 PM 24152212 ER PT J AU Patel, JC Taylor, SM Juliao, PC Parobek, CM Janko, M Gonzalez, LD Ortiz, L Padilla, N Tshefu, AK Emch, M Udhayakumar, V Lindblade, K Meshnick, SR AF Patel, Jaymin C. Taylor, Steve M. Juliao, Patricia C. Parobek, Christian M. Janko, Mark Gonzalez, Luis Demetrio Ortiz, Lucia Padilla, Norma Tshefu, Antoinette K. Emch, Michael Udhayakumar, Venkatachalam Lindblade, Kim Meshnick, Steven R. TI Genetic Evidence of Importation of Drug-Resistant Plasmodium falciparum to Guatemala from the Democratic Republic of the Congo SO EMERGING INFECTIOUS DISEASES LA English DT Article ID MICROSATELLITE MARKERS; ANOPHELES-ALBIMANUS; POPULATION; MALARIA; TRANSMISSION; ELIMINATION; PREVALENCE; REVEAL AB Imported malaria threatens control and elimination efforts in countries that have low rates of transmission. In 2010, an outbreak of Plasmodium falciparum malaria was reported among United Nations peacekeeping soldiers from Guatemala who had recently returned from the Democratic Republic of the Congo (DRC). Epidemiologic evidence suggested that the soldiers were infected in the DRC, but local transmission could not be ruled out in all cases. We used population genetic analyses of neutral microsatellites to determine the outbreak source. Genetic relatedness was compared among parasites found in samples from the soldiers and parasite populations collected in the DRC and Guatemala; parasites identified in the soldiers were more closely related to those from the DRC. A phylogenetic clustering analysis confirms this identification with >99.9% confidence. Thus, results support the hypothesis that the soldiers likely imported malaria from the DRC. This study demonstrates the utility of molecular genotyping in outbreak investigations. C1 [Patel, Jaymin C.; Taylor, Steve M.; Parobek, Christian M.; Janko, Mark; Emch, Michael; Meshnick, Steven R.] Univ N Carolina, Chapel Hill, NC 27599 USA. [Juliao, Patricia C.; Udhayakumar, Venkatachalam; Lindblade, Kim] Ctr Dis Control & Prevent, Atlanta, GA USA. [Gonzalez, Luis Demetrio] Mil Med Ctr, Guatemala City, Guatemala. [Ortiz, Lucia; Padilla, Norma] Univ Valle Guatemala, Guatemala City, Guatemala. [Tshefu, Antoinette K.] Univ Kinshasa, Kinshasa, Congo. RP Patel, JC (reprint author), Univ N Carolina, 135 Dauer Dr,3206 Michael Hooker Res Bldg, Chapel Hill, NC 27599 USA. EM jaymin86@email.unc.edu FU Gillings Innovation Laboratory award from the UNC Gillings School of Global Public Health; National Institutes of Health (NIH) [NIAID 1R56AI097609-01]; National Science Foundation (NSF) [BSC-13339949] FX This work was supported by a Gillings Innovation Laboratory award from the UNC Gillings School of Global Public Health and by grants from the National Institutes of Health (NIH) (NIAID 1R56AI097609-01) and National Science Foundation (NSF) (BSC-13339949). NR 39 TC 8 Z9 8 U1 0 U2 4 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JUN PY 2014 VL 20 IS 6 BP 932 EP 940 DI 10.3201/eid2006.131204 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AI0SZ UT WOS:000336561600002 PM 24856348 ER PT J AU Watson, JT Hall, AJ Erdman, DD Swerdlow, DL Gerber, SI AF Watson, John T. Hall, Aron J. Erdman, Dean D. Swerdlow, David L. Gerber, Susan I. TI Unraveling the Mysteries of Middle East Respiratory Syndrome Coronavirus SO EMERGING INFECTIOUS DISEASES LA English DT Editorial Material ID DROMEDARY CAMELS; MERS CORONAVIRUS; SAUDI-ARABIA; ANTIBODIES; LIVESTOCK C1 [Watson, John T.; Hall, Aron J.; Erdman, Dean D.; Swerdlow, David L.; Gerber, Susan I.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Watson, JT (reprint author), Ctr Dis Control & Prevent, Div Viral Dis, 1600 Clifton Rd NE,Mailstop A34, Atlanta, GA 30333 USA. EM acq4@cdc.gov NR 19 TC 2 Z9 2 U1 0 U2 7 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JUN PY 2014 VL 20 IS 6 BP 1054 EP 1056 DI 10.3201/eid2006.140322 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AI0SZ UT WOS:000336561600024 PM 24983095 ER PT J AU Breedlove, B AF Breedlove, Byron TI Quiet Moment around the Campfire SO EMERGING INFECTIOUS DISEASES LA English DT Editorial Material C1 [Breedlove, Byron] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. RP Breedlove, B (reprint author), Ctr Dis Control & Prevent, EID Journal, 1600 Clifton Rd NE,Mailstop C14, Atlanta, GA 30329 USA. EM wbb1@cdc.gov OI Breedlove, Byron/0000-0002-1026-1963 NR 7 TC 0 Z9 0 U1 0 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JUN PY 2014 VL 20 IS 6 BP 1092 EP 1093 DI 10.3201/eid2006.AC2006 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AI0SZ UT WOS:000336561600042 ER PT J AU Kramarow, E Warner, M Chen, LH AF Kramarow, Ellen Warner, Margaret Chen, Li-Hui TI Food-related choking deaths among the elderly SO INJURY PREVENTION LA English DT Article ID ASPIRATION AB During 2007-2010 in the USA, 2214 deaths among people aged >= 65 were attributed to choking on food. The death rate for this cause is higher among the elderly than among any other age group. Using data from the US National Vital Statistics System, we examined the relationship between food suffocation and other causes of death listed on the death certificate. Among decedents aged >= 65, the three most common additional conditions listed on the death certificate were heart disease, dementia and diabetes. However, after estimating the expected joint frequency of other causes based on the overall distribution of all causes of death, we find that three causes-dementia (including Alzheimer's disease), Parkinson's disease and pneumonitis-are most strongly associated with deaths from choking on food among older people. C1 [Kramarow, Ellen; Chen, Li-Hui] Ctr Dis Control & Prevent, Off Anal & Epidemiol, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Warner, Margaret] Ctr Dis Control & Prevent, Div Vital Stat, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. RP Kramarow, E (reprint author), Ctr Dis Control & Prevent, Off Anal & Epidemiol, Natl Ctr Hlth Stat, 3311 Toledo Rd, Hyattsville, MD 20782 USA. EM ekramarow@cdc.gov NR 22 TC 1 Z9 1 U1 0 U2 5 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1353-8047 EI 1475-5785 J9 INJURY PREV JI Inj. Prev. PD JUN PY 2014 VL 20 IS 3 BP 200 EP 203 DI 10.1136/injuryprev-2013-040795 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AI3CE UT WOS:000336735700013 PM 24003082 ER PT J AU Cooper, CP Gelb, CA Rodriguez, J Hawkins, NA AF Cooper, Crystale Purvis Gelb, Cynthia A. Rodriguez, Juan Hawkins, Nikki A. TI Promoting Gynecologic Cancer Awareness at a Critical Juncture-Where Women and Providers Meet SO JOURNAL OF CANCER EDUCATION LA English DT Article DE Primary care; Health promotion; Prevention; Patient education; Gynecologic cancer ID OVARIAN-CANCER; UNITED-STATES; US WOMEN; SYMPTOMS; CARE; PHYSICIANS; KNOWLEDGE; SEEKING AB Given the absence of effective population-based screening tests for ovarian, uterine, vaginal, and vulvar cancers, early detection can depend on women and health care providers recognizing the potential significance of symptoms. In 2008, the Centers for Disease Control and Prevention's (CDC) Inside Knowledge campaign began distributing consumer education materials promoting awareness of gynecologic cancer symptoms. We investigated providers' in-office use of CDC gynecologic cancer materials and their recognition of the symptoms highlighted in the materials. We analyzed data from a national 2012 survey of US primary care physicians, nurse practitioners, and gynecologists (N = 1,380). Less than a quarter of providers (19.4 %) reported using CDC gynecologic cancer education materials in their offices. The provider characteristics associated with the use of CDC materials were not consistent across specialties. However, recognition of symptoms associated with gynecologic cancers was consistently higher among providers who reported using CDC materials. The possibility that providers were educated about gynecologic cancer symptoms through the dissemination of materials intended for their patients is intriguing and warrants further investigation. Distributing consumer education materials in health care provider offices remains a priority for the Inside Knowledge campaign, as the setting where women and health care providers interact is one of the most crucial venues to promote awareness of gynecologic cancer symptoms. C1 [Cooper, Crystale Purvis] Soltera Ctr Canc Prevent & Control, Tucson, AZ 85704 USA. [Gelb, Cynthia A.; Rodriguez, Juan; Hawkins, Nikki A.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Gelb, Cynthia A.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Chamblee, GA 30341 USA. RP Gelb, CA (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, 3719 North Peachtree,MS F75,Chamblee Bldg 107, Chamblee, GA 30341 USA. EM cgelb@cdc.gov FU Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention FX Funding for this study was provided by the Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, which licensed the 2012 DocStyles data analyzed from Porter Novelli (Washington DC). The authors thank Pedro J. Rodriguez, Northrop Grumman Corporation, for extracting the web site materials download data. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 14 TC 0 Z9 0 U1 1 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0885-8195 EI 1543-0154 J9 J CANCER EDUC JI J. Cancer Educ. PD JUN PY 2014 VL 29 IS 2 BP 247 EP 251 DI 10.1007/s13187-013-0580-z PG 5 WC Oncology; Education, Scientific Disciplines; Public, Environmental & Occupational Health SC Oncology; Education & Educational Research; Public, Environmental & Occupational Health GA AH8LZ UT WOS:000336390600009 PM 24214840 ER PT J AU Gaglani, M Spencer, S Ball, S Song, J Naleway, A Henkle, E Bozeman, S Reynolds, S Sessions, W Hancock, K Thompson, M AF Gaglani, Manjusha Spencer, Sarah Ball, Sarah Song, Juhee Naleway, Allison Henkle, Emily Bozeman, Sam Reynolds, Sue Sessions, Wendy Hancock, Kathy Thompson, Mark TI Antibody Response to Influenza A(H1N1)pdm09 Among Healthcare Personnel Receiving Trivalent Inactivated Vaccine: Effect of Prior Monovalent Inactivated Vaccine SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE hemagglutination inhibition antibody; influenza vaccine immunogenicity or response; healthcare workers; 2009 influenza pandemic H1N1; influenza vaccine ID IMMUNIZATION PRACTICES ACIP; SELF-RATED HEALTH; A H1N1 VACCINE; UNITED-STATES; VIRUS VACCINE; ADVISORY-COMMITTEE; CONSECUTIVE YEARS; IMMUNE-RESPONSE; ELDERLY ADULTS; EFFICACY AB Background. Few data are available on the immunogenicity of repeated annual doses of influenza A(H1N1) pdm09-containing vaccines. Methods.aEuro integral We enrolled healthcare personnel (HCP) in direct patient care during the autumn of 2010 at 2 centers with voluntary immunization. We verified the receipt of A(H1N1)pdm09-containing monovalent inactivated influenza vaccine (MIIV) and 2010-2011 trivalent inactivated vaccine (TIV). We performed hemagglutination inhibition antibody (HI) assays on preseason, post-TIV, and end-of-season serum samples. We compared the proportion of HCPs with HI titer a parts per thousand yen40 against A(H1N1)pdm09 per receipt of prior-season MIIV, current-season TIV, both, or neither. Results.aEuro integral At preseason (n = 1417), HI a parts per thousand yen 40 was significantly higher among those who received MIIV (34%) vs those who did not (14%) (adjusted relative risk [ARR], 3.26; 95% confidence interval [CI], 2.72-3.81). At post-TIV (n = 865), HI a parts per thousand yen 40 was lower among HCP who received MIIV and TIV (66%) than among those receiving only TIV (85%) (ARR, 0.93 [95% CI, .84-.997]). At end-of-season (n = 1254), HI a parts per thousand yen 40 was 40% among those who received both MIIV and TIV and 67% among those receiving only TIV (ARR, 0.76 [95% CI, .65-.88]), 52% among those who received MIIV only, and 12% among those receiving neither. Conclusions.aEuro integral HCP immunization programs should consider effects of host immune response and vaccine antigenic distance on immunogenicity of repeated annual doses of influenza vaccines. C1 [Gaglani, Manjusha] Scott & White Healthcare, Texas A&M Hlth Sci Ctr, Div Pediat Infect Dis, Temple, TX USA. [Song, Juhee] Scott & White Healthcare, Texas A&M Hlth Sci Ctr, Div Res, Temple, TX USA. [Spencer, Sarah; Reynolds, Sue; Sessions, Wendy; Thompson, Mark] Ctr Dis Control & Prevent, Epidemiol & Prevent Branch, Atlanta, GA USA. [Hancock, Kathy] Ctr Dis Control & Prevent, Immunol & Pathogenesis Branch, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Bozeman, Sam] Abt Associates Inc, Cambridge, MA USA. [Naleway, Allison; Henkle, Emily] Kaiser Permanente Northwest, Ctr Hlth Res, Portland, OR USA. RP Gaglani, M (reprint author), McLane Childrens Hosp, Scott & White Healthcare, Texas A&M HSC COM, 2401 S 31st St, Temple, TX 76508 USA. EM mgaglani@sw.org OI Naleway, Allison/0000-0001-5747-4643 FU CDC [200-2010-F-33396] FX This work was supported by the CDC (contract 200-2010-F-33396 to Abt Associates Inc). This research was supported in part by an appointment to the Research Participation Program at the CDC administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and the CDC. NR 50 TC 7 Z9 7 U1 0 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD JUN 1 PY 2014 VL 209 IS 11 BP 1705 EP 1714 DI 10.1093/infdis/jit825 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AH9TP UT WOS:000336485900006 PM 24363436 ER PT J AU Fowlkes, A Giorgi, A Erdman, D Temte, J Goodin, K Di Lonardo, S Sun, YM Martin, K Feist, M Linz, R Boulton, R Bancroft, E McHugh, L Lojo, J Filbert, K Finelli, L AF Fowlkes, Ashley Giorgi, Andrea Erdman, Dean Temte, Jon Goodin, Kate Di Lonardo, Steve Sun, Yumei Martin, Karen Feist, Michelle Linz, Rachel Boulton, Rachelle Bancroft, Elizabeth McHugh, Lisa Lojo, Jose Filbert, Kimberly Finelli, Lyn CA IISP Working Grp TI Viruses Associated With Acute Respiratory Infections and Influenza-like Illness Among Outpatients From the Influenza Incidence Surveillance Project, 2010-2011 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE influenza; respiratory virus; influenza-like illness; acute respiratory illness; seasonality; epidemiology ID SYNCYTIAL VIRUS; UNITED-STATES; YOUNG-CHILDREN; TRACT INFECTIONS; US CHILDREN; BURDEN; PCR; DISEASE; TIME; EPIDEMIOLOGY AB Background. The Influenza Incidence Surveillance Project (IISP) monitored outpatient acute respiratory infection (ARI; defined as the presence of >= 2 respiratory symptoms not meeting ILI criteria) and influenza-like illness (ILI) to determine the incidence and contribution of associated viral etiologies. Methods.aEuro integral From August 2010 through July 2011, 57 outpatient healthcare providers in 12 US sites reported weekly the number of visits for ILI and ARI and collected respiratory specimens on a subset for viral testing. The incidence was estimated using the number of patients in the practice as the denominator, and the virus-specific incidence of clinic visits was extrapolated from the proportion of patients testing positive. Results.aEuro integral The age-adjusted cumulative incidence of outpatient visits for ARI and ILI combined was 95/1000 persons, with a viral etiology identified in 58% of specimens. Most frequently detected were rhinoviruses/enteroviruses (RV/EV) (21%) and influenza viruses (21%); the resulting extrapolated incidence of outpatient visits was 20 and 19/1000 persons respectively. The incidence of influenza virus-associated clinic visits was highest among patients aged 2-17 years, whereas other viruses had varied patterns among age groups. Conclusions.aEuro integral The IISP provides a unique opportunity to estimate the outpatient respiratory illness burden by etiology. Influenza virus infection and RV/EV infection(s) represent a substantial burden of respiratory disease in the US outpatient setting, particularly among children. C1 [Fowlkes, Ashley; Finelli, Lyn] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. [Erdman, Dean] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA. [Giorgi, Andrea] Council State & Territorial Epidemiologists, Atlanta, GA USA. [Temte, Jon] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI USA. [Goodin, Kate] Florida Dept Hlth, Tallahassee, FL USA. [Di Lonardo, Steve] New York City Dept Hlth & Mental Hyg, New York, NY USA. [Sun, Yumei] Iowa Dept Publ Hlth, Des Moines, IA 50319 USA. [Martin, Karen] Minnesota Dept Hlth, Minneapolis, MN 55414 USA. [Feist, Michelle] North Dakota Dept Hlth, Bismarck, ND USA. [Linz, Rachel] Oregon Publ Hlth Div, Portland, OR USA. [Boulton, Rachelle] Utah Dept Hlth, Salt Lake City, UT 84116 USA. [Bancroft, Elizabeth] Los Angeles Cty Dept Publ Hlth, Los Angeles, CA USA. [McHugh, Lisa] New Jersey State Dept Hlth, Trenton, NJ 08625 USA. [Lojo, Jose] Philadelphia Dept Publ Hlth, Philadelphia, PA USA. [Filbert, Kimberly] Virgina Dept Hlth, Richmond, VA USA. RP Fowlkes, A (reprint author), 1600 Clifton Rd NE,Mailstop A-32, Atlanta, GA 30333 USA. EM afowlkes@cdc.gov OI Lang, Brian/0000-0002-9362-0086 FU Council of State and Territorial Epidemiologists (Centers for Disease Control and Prevention). [5U38HM000414-04] FX This work was supported by the Council of State and Territorial Epidemiologists (cooperative agreement 5U38HM000414-04 from the Centers for Disease Control and Prevention). NR 36 TC 17 Z9 17 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD JUN 1 PY 2014 VL 209 IS 11 BP 1715 EP 1725 DI 10.1093/infdis/jit806 PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AH9TP UT WOS:000336485900007 PM 24338352 ER PT J AU Steinau, M Hariri, S Gillison, ML Broutian, TR Dunne, EF Tong, ZY Markowitz, LE Unger, ER AF Steinau, Martin Hariri, Susan Gillison, Maura L. Broutian, Tatevic R. Dunne, Eileen F. Tong, Zhen-yue Markowitz, Lauri E. Unger, Elizabeth R. TI Prevalence of Cervical and Oral Human Papillomavirus Infections Among US Women SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE human papillomavirus; cervix; oral cavity; HPV prevalence; NHANES ID UNITED-STATES; HPV INFECTION; NATIONAL-HEALTH; NEGATIVE WOMEN; FEMALES; CANCER AB Data from the National Health and Nutrition Examination Survey, 2009-2010, indicated that the prevalence of human papillomavirus (HPV) infection among women was 42.7% in the cervix and 3.8% in the oral cavity. The prevalence of oral HPV infection was 5-fold higher among women with than among those without cervical HPV infection (7.0% vs 1.4%; prevalence ratio, 4.9 [95% confidence interval, 2.7-8.7]). Among the 3% of women with HPV detected at both sites, complete type concordance was detected in 6.6%, and partial agreement was detected in 37.7%. These data suggest that HPV infections at these 2 sites are not independent, although type-specific concordance is low. C1 [Steinau, Martin; Unger, Elizabeth R.] Ctr Dis Control & Prevent, Chron Viral Dis Branch, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Hariri, Susan; Dunne, Eileen F.; Markowitz, Lauri E.] Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Gillison, Maura L.; Broutian, Tatevic R.; Tong, Zhen-yue] Ohio State Univ, Columbus, OH 43210 USA. RP Steinau, M (reprint author), Ctr Dis Control & Prevent, Chron Viral Dis Branch, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM MSteinau@cdc.gov FU Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention; National Center for Health Statistics, Centers for Disease Control and Prevention; Ohio State University Comprehensive Cancer Center; Merck; John and Nina Cassils; National Cancer Institute FX This work was supported by the Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, and the National Center for Health Statistics, Centers for Disease Control and Prevention; work conducted at Ohio State University was supported by the Ohio State University Comprehensive Cancer Center, Merck, John and Nina Cassils, and the Intramural Research Program of the National Cancer Institute. NR 15 TC 13 Z9 14 U1 0 U2 4 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD JUN 1 PY 2014 VL 209 IS 11 BP 1739 EP 1743 DI 10.1093/infdis/jit799 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AH9TP UT WOS:000336485900010 PM 24319284 ER PT J AU Zetola, NM Modongo, C Moonan, PK Ncube, R Matlhagela, K Sepako, E Collman, RG Bisson, GP AF Zetola, Nicola M. Modongo, Chawangwa Moonan, Patrick K. Ncube, Ronald Matlhagela, Keikantse Sepako, Enoch Collman, Ronald G. Bisson, Gregory P. TI Clinical Outcomes Among Persons With Pulmonary Tuberculosis Caused by Mycobacterium tuberculosis Isolates With Phenotypic Heterogeneity in Results of Drug-Susceptibility Tests SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE Tuberculosis; multidrug-resistant tuberculosis; mixed infection; heteroresistance; treatment outcome; drug susceptibility testing ID MULTIDRUG-RESISTANT TUBERCULOSIS; EXOGENOUS REINFECTION; MIXED INFECTION; SOUTH-AFRICA; BOTSWANA; STRAIN; HOUSEHOLDS; EVOLUTION; THERAPY; ADULTS AB Background. Patients with multidrug- resistant (MDR) tuberculosis may have phenotypic heterogeneity in results of drug-susceptibility tests (DSTs). However, the impact of this on clinical outcomes among patients treated for MDR tuberculosis is unknown. Methods.aEuro integral Phenotypic DST heterogeneity was defined as presence of at least 1 Mycobacterium tuberculosis isolate susceptible to rifampicin and isoniazid recovered < 3 months after MDR tuberculosis treatment initiation from a patient with previous documented tuberculosis due to M. tuberculosis resistant to at least rifampicin and isoniazid. The primary outcome was defined as good (ie, cure or treatment completion) or poor (ie, treatment failure, treatment default, or death). A secondary outcome was time to culture conversion. Cox proportional hazard models were used to determine the association between phenotypic DST heterogeneity and outcomes. Results.aEuro integral Phenotypic DST heterogeneity was identified in 33 of 475 patients (7%) with MDR tuberculosis. Poor outcome occurred in 126 patients (28%). Overall, patients with MDR tuberculosis who had phenotypic DST heterogeneity were at greater risk of poor outcome than those with MDR tuberculosis but no phenotypic DST heterogeneity (adjusted hazard ratio [aHR], 2.1; 95% confidence interval [CI], 1.2-3.6). Among HIV-infected patients with MDR tuberculosis, the adjusted hazard for a poor outcome for those with phenotypic DST heterogeneity was 2.4 (95% CI, 1.3-4.2) times that for those without phenotypic DST heterogeneity, whereas among HIV-negative patients with MDR tuberculosis, the adjusted hazard for those with phenotypic DST heterogeneity was 1.5 (95% CI, .5-4.3) times that for those without phenotypic DST heterogeneity. HIV-infected patients with MDR tuberculosis with phenotypic DST heterogeneity also had a longer time to culture conversion than with HIV-infected patients with MDR tuberculosis without phenotypic DST heterogeneity (aHR, 2.9; 95% CI, 1.4-6.0). Conclusions.aEuro integral Phenotypic DST heterogeneity among persons with HIV infection who are being treated for MDR tuberculosis is associated with poor outcomes and longer times to culture conversion. C1 [Zetola, Nicola M.; Bisson, Gregory P.] Univ Penn, Div Infect Dis, Philadelphia, PA 19104 USA. [Collman, Ronald G.] Univ Penn, Div Pulm & Crit Care Med, Philadelphia, PA 19104 USA. [Moonan, Patrick K.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Zetola, Nicola M.; Modongo, Chawangwa; Bisson, Gregory P.] Botswana Univ Pennsylvania Partnership, Gaborone, Botswana. [Zetola, Nicola M.] Univ Botswana, Dept Med, Gaborone, Botswana. [Matlhagela, Keikantse; Sepako, Enoch] Univ Botswana, Dept Biol Sci, Gaborone, Botswana. [Zetola, Nicola M.; Modongo, Chawangwa] Princess Marina Referral Hosp, Gaborone, Botswana. [Ncube, Ronald] Botswana Natl TB Programme, Gaborone, Botswana. RP Zetola, NM (reprint author), Botswana UPenn Partnership, 214 Independence Ave, Gaborone, Botswana. EM nzetola@gmail.com OI Moonan, Patrick/0000-0002-3550-2065 FU National Institutes of Health [R01AI097045, P30AI45008] FX This work was supported by the National Institutes of Health (grants R01AI097045 and P30AI45008 to the Penn Centre for AIDS Research). NR 35 TC 12 Z9 12 U1 0 U2 5 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD JUN 1 PY 2014 VL 209 IS 11 BP 1754 EP 1763 DI 10.1093/infdis/jiu040 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AH9TP UT WOS:000336485900012 PM 24443546 ER PT J AU Mei, ZG Serdula, MK Liu, JM Flores-Ayala, RC Wang, LL Ye, RW Grummer-Strawn, LM AF Mei, Zuguo Serdula, Mary K. Liu, Jian-meng Flores-Ayala, Rafael C. Wang, Linlin Ye, Rongwei Grummer-Strawn, Laurence M. TI Iron-Containing Micronutrient Supplementation of Chinese Women with No or Mild Anemia during Pregnancy Improved Iron Status but Did Not Affect Perinatal Anemia SO JOURNAL OF NUTRITION LA English DT Article ID SERUM TRANSFERRIN RECEPTOR; REFERENCE RANGES; DEFICIENCY AB Universal prenatal daily iron folic acid (IFA) and multiple micronutrient (MM) supplements are recommended to reduce the risk of low birth weight, maternal anemia, and iron deficiency (ID) during pregnancy, but the evidence of their effect on iron status among women with mild or no anemia is limited. The aim of this study was to-describe the iron status [serum ferritin (SF), serum soluble transferrin receptor (sTfR), and body iron (BI)] before and after micronutrient supplementation during pregnancy. We examined 834 pregnant women with hemoglobin > 100 g/L at enrollment before 20 wk of gestation and with iron measurement data from a subset of a randomized, double-blind trial in China. Women were randomly assigned to take daily 400 mu g of folic acid (FA) (control), FA plus 30 mg of iron, or FA, iron, plus 13 additional MMs provided before 20 wk of gestation to delivery. Venous blood was collected in this subset during study enrollment (before 20 wk of gestation) and 28-32 wk of gestation. We found that, at 28-32 wk of-gestation, compared with the FA group, both the IFA and MM groups had significantly lower prevalence of ID regardless of which indicator (SF, sTfR, or BI) was used for defining ID. The prevalence of ID at 28-32 wk of gestation for IFA, MM, and FA were 35.3%, 42.7%, and 59.6% by using low SF, 53.6%, 59.9%, and 69.9% by using high sTfR, and 34.5%, 41.2%, and 59.6% by using low BI, respectively. However, there was no difference in anemia prevalence (hemoglobin < 110 g/L) between FA and IFA or MM groups. We concluded that, compared with FA alone, prenatal IFA and MM supplements provided to women with no or mild anemia improved iron status later during pregnancy but did not affect perinatal anemia. This trial was registered at clinicaltrials.gov as NCT00137744. C1 [Mei, Zuguo; Serdula, Mary K.; Flores-Ayala, Rafael C.; Grummer-Strawn, Laurence M.] CDC, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Liu, Jian-meng; Wang, Linlin; Ye, Rongwei] Peking Univ, Hlth Sci Ctr, Inst Reprod & Child Hlth, Minist Hlth,Key Lab Reprod Hlth, Beijing 100871, Peoples R China. RP Ye, RW (reprint author), Peking Univ, Hlth Sci Ctr, Inst Reprod & Child Hlth, Minist Hlth,Key Lab Reprod Hlth, Beijing 100871, Peoples R China. EM yerw@bjmu.edu.cn FU Peking University Health Science Center; CDC FX Supported by,a cooperative agreement between Peking University Health Science Center and the CDC. The findings and conclusions in this report are those-of the authors and do not necessarily represent the official position of the CDC. NR 15 TC 5 Z9 5 U1 4 U2 8 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-3166 EI 1541-6100 J9 J NUTR JI J. Nutr. PD JUN PY 2014 VL 144 IS 6 BP 943 EP 948 DI 10.3945/jn.113.189894 PG 6 WC Nutrition & Dietetics SC Nutrition & Dietetics GA AH9LZ UT WOS:000336465200022 PM 24744317 ER PT J AU Valenzuela, JM Seid, M Waitzfelder, B Anderson, AM Beavers, DP Dabelea, DM Dolan, LM Imperatore, G Marcovina, S Reynolds, K Yi-Frazier, J Mayer-Davis, EJ AF Valenzuela, Jessica M. Seid, Michael Waitzfelder, Beth Anderson, Andrea M. Beavers, Daniel P. Dabelea, Dana M. Dolan, Lawrence M. Imperatore, Giuseppina Marcovina, Santica Reynolds, Kristi Yi-Frazier, Joyce Mayer-Davis, Elizabeth J. CA SEARCH Diabet Youth Study Grp TI Prevalence of and Disparities in Barriers to Care Experienced by Youth with Type 1 Diabetes SO JOURNAL OF PEDIATRICS LA English DT Article ID HEALTH-CARE; PROSPECTIVE COHORT; GLYCEMIC CONTROL; CHILDREN; NEEDS; QUALITY; ACCESS; QUESTIONNAIRE; ADOLESCENTS; INSURANCE AB Objective To describe the prevalence of access and process barriers to health care and to examine their relationship to sociodemographic and disease factors in a large and diverse cohort of US youth with type 1 diabetes. Study design A cross-sectional analysis of 780 youth who participated in the SEARCH for Diabetes in Youth Study and were diagnosed with type 1 diabetes in 2002-2005. Experience of barriers to care was collected from parent report on questionnaires. Analyses included multivariate regression models to predict the presence of specific barriers to care. Results Overall, 81.7% of participants reported at least one barrier; the 3 most common were costs (47.5%), communication (43.0%), and getting needed information (48.4%). Problems with access to care, not having a regular provider, and receiving contextual care (care that takes into account personal and family context) were associated with poorer glycated hemoglobin levels. Adjusted multivariate models indicated that barriers related to access (regular provider, cost) were most likely for youth with low family income and those without public health insurance. Barriers associated with the processes of quality care (contextual care, communication) were more likely for Hispanic youth and those whose parents had less education. Conclusions This study indicates that a large proportion of youth with type 1 diabetes experience substantial barriers to care. Barriers to access and those associated with processes of quality care differed by sociodemographic characteristics. Future investigators should expand knowledge of the systemic processes that lead to disparate outcomes for some youth with diabetes and assess potential solutions. C1 [Valenzuela, Jessica M.] Nova SE Univ, Ctr Psychol Studies, Ft Lauderdale, FL 33314 USA. [Seid, Michael] Cincinnati Childrens Hosp Med Ctr, Div Pulm Med, Cincinnati, OH 45229 USA. [Seid, Michael] Cincinnati Childrens Hosp Med Ctr, James M Anderson Ctr Hlth Syst Excellence, Cincinnati, OH 45229 USA. [Waitzfelder, Beth] Pacific Hlth Res Inst, Honolulu, HI USA. [Waitzfelder, Beth] Kaiser Permanente Ctr Hlth Res Hawaii, Honolulu, HI USA. [Anderson, Andrea M.; Beavers, Daniel P.] Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC USA. [Dabelea, Dana M.] Univ Colorado, Dept Epidemiol, Colorado Sch Publ Hlth, Denver, CO 80202 USA. [Dolan, Lawrence M.] Cincinnati Childrens Hosp Med Ctr, Div Endocrinol, Cincinnati, OH 45229 USA. [Imperatore, Giuseppina] Ctr Dis Control & Prevent, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Marcovina, Santica] Univ Washington, Dept Med, Seattle, WA USA. [Reynolds, Kristi] Kaiser Permanente So Calif, Dept Res & Evaluat, Pasadena, CA 91101 USA. [Yi-Frazier, Joyce] Seattle Childrens Hosp, Seattle, WA USA. [Mayer-Davis, Elizabeth J.] Univ N Carolina, Dept Nutr, Gillings Sch Global Publ, Chapel Hill, NC USA. [Mayer-Davis, Elizabeth J.] Univ N Carolina, Sch Med, Chapel Hill, NC USA. RP Valenzuela, JM (reprint author), Nova SE Univ, Ctr Psychol Studies, 3301 Coll Ave, Ft Lauderdale, FL 33314 USA. EM Jessica.Valenzuela@nova.edu RI Beavers, Daniel/G-5338-2016; Dagostino Jr, Ralph/C-4060-2017 OI Dagostino Jr, Ralph/0000-0002-3550-8395 FU NCATS NIH HHS [UL1 TR000077, UL1 TR001082, UL1 TR000423, UL1 TR000154]; NCCDPHP CDC HHS [U01 DP000246, DP-05-069, DP-10-001, U18DP002710-01, U01 DP000250, U18DP002714, U18DP002708-01, U18DP000247-06A1, U01 DP000244, U01 DP000247, U01 DP000254, U01 DP000248, U01 DP000245, 1U18DP002709]; NCRR NIH HHS [UL1RR029882, M01 RR00069, UL1 RR029882, M01RR00037, 1UL1RR026314-01]; NIDDK NIH HHS [P30 DK57516, P30 DK057516, K23 DK089017]; PHS HHS [U58/CCU019235-4, U48/CCU819241-3, U48/CCU519239, 200-2010-35171, U48/CCU419249, 00097, U58CCU919256, U48/CCU919219] NR 29 TC 16 Z9 16 U1 3 U2 8 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD JUN PY 2014 VL 164 IS 6 BP 1369 EP + DI 10.1016/j.jpeds.2014.01.035 PG 8 WC Pediatrics SC Pediatrics GA AH9YX UT WOS:000336503200029 PM 24582008 ER PT J AU Li, GW Zhang, P Wang, JP An, YL Gong, QH Gregg, EW Yang, WY Zhang, B Shuai, Y Hong, J Engelgau, MM Li, H Roglic, G Hu, Y Bennett, PH AF Li, Guangwei Zhang, Ping Wang, Jinping An, Yali Gong, Qiuhong Gregg, Edward W. Yang, Wenying Zhang, Bo Shuai, Ying Hong, Jing Engelgau, Michael M. Li, Hui Roglic, Gojka Hu, Yinghua Bennett, Peter H. TI Cardiovascular mortality, all-cause mortality, and diabetes incidence after lifestyle intervention for people with impaired glucose tolerance in the Da Qing Diabetes Prevention Study: a 23-year follow-up study SO LANCET DIABETES & ENDOCRINOLOGY LA English DT Article ID RANDOMIZED CONTROLLED-TRIALS; FASTING GLUCOSE; ADULT DEATHS; METFORMIN; MELLITUS; PROGRAM; IMPACT; CHINA; RISK; METAANALYSIS AB Background Lifestyle interventions among people with impaired glucose tolerance reduce the incidence of diabetes, but their effect on all-cause and cardiovascular disease mortality is unclear. We assessed the long-term effect of lifestyle intervention on long-term outcomes among adults with impaired glucose tolerance who participated in the Da Qing Diabetes Prevention Study. Methods The study was a cluster randomised trial in which 33 clinics in Da Qing, China-serving 577 adults with impaired glucose tolerance-were randomised (1: 1: 1: 1) to a control group or lifestyle intervention groups (diet or exercise or both). Patients were enrolled in 1986 and the intervention phase lasted for 6 years. In 2009, we followed up participants to assess the primary outcomes of cardiovascular mortality, all-cause mortality, and incidence of diabetes in the intention-to-treat population. Findings Of the 577 patients, 439 were assigned to the intervention group and 138 were assigned to the control group (one refused baseline examination). 542 (94%) of 576 participants had complete data for mortality and 568 (99%) contributed data to the analysis. 174 participants died during the 23 years of follow-up (121 in the intervention group vs 53 in the control group). Cumulative incidence of cardiovascular disease mortality was 11.9% (95% CI 8.8-15.0) in the intervention group versus 19.6% (12.9-26.3) in the control group (hazard ratio [HR] 0.59, 95% CI 0.36-0 96; p=0.033). All-cause mortality was 28.1% (95% CI 23.9-32 4) versus 38.4% (30.3-46.5; HR 0 71, 95% CI 0.51-0.99; p=0.049). Incidence of diabetes was 72.6% (68.4-76.8) versus 89.9% (84.9-94.9; HR 0.55, 95% CI 0.40-0.76; p=0.001). Interpretation A 6-year lifestyle intervention programme for Chinese people with impaired glucose tolerance can reduce incidence of cardiovascular and all-cause mortality and diabetes. These findings emphasise the long-term clinical benefits of lifestyle intervention for patients with impaired glucose tolerance and provide further justification for adoption of lifestyle interventions as public health measures to control the consequences of diabetes. C1 [Li, Guangwei; Yang, Wenying; Zhang, Bo; Shuai, Ying; Hong, Jing] China Japan Friendship Hosp, Dept Endocrinol, Beijing, Peoples R China. [Li, Guangwei; An, Yali; Gong, Qiuhong] Natl Ctr Cardiol, Ctr Endocrinol & Cardiovasc Dis, Beijing, Peoples R China. [Li, Guangwei; An, Yali; Gong, Qiuhong] Fuwai Hosp, Beijing, Peoples R China. [Zhang, Ping; Gregg, Edward W.] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA 30341 USA. [Engelgau, Michael M.] Ctr Dis Control & Prevent, Ctr Global Hlth, Atlanta, GA 30341 USA. [Wang, Jinping; Li, Hui; Hu, Yinghua] Da Qing First Hosp, Dept Cardiol, Da Qing, Peoples R China. [Roglic, Gojka] WHO, Dept Management Noncommunicable Dis, CH-1211 Geneva, Switzerland. [Bennett, Peter H.] NIDDK, Phoenix Epidemiol & Clin Res Branch, Phoenix, AZ USA. RP Li, GW (reprint author), Dept Endocrinol, 167 Beilishi Rd, Beijing 100037, Peoples R China. EM guangwei_li@medmail.com.cn; pzhang@cdc.gov FU CDC/WHO [U58/CCU424123-01-02]; China-Japan Friendship Hospital FX Supported by CDC/WHO Cooperative Agreement No. U58/CCU424123-01-02 and the China-Japan Friendship Hospital. We thank the participants in the original Da Qing Diabetes Prevention Study and their proxies who contributed to the follow-up study. We also thank Lingzhi Kong, China Ministry of Health, the leadership at the China-Japan Friendship Hospital, Da Qing First Hospital, the Da Qing City Health Bureau, and the Beijing and West Pacific Regional Office of WHO for their general support. We thank Xilin Yang (Tianjin Medical University), Yang Yang (National Center of Cardiology and Fuwai Hospital, China), and Ted Thompson (Centers for Disease Control and Prevention, USA) for statistical advice. Our special thanks go to the late Prof Xiaoren Pan as this study would not have been possible without his leadership in the design and implementation of the original Da Qing Diabetes Prevention Study. The contents of this report are solely the responsibility of the authors and do not necessarily represent the official positions of the Centers for Disease Control and Prevention, the National Institute of Diabetes and Digestive and Kidney Diseases, or WHO. NR 33 TC 128 Z9 138 U1 11 U2 41 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 2213-8587 J9 LANCET DIABETES ENDO JI Lancet Diabetes Endocrinol. PD JUN PY 2014 VL 2 IS 6 BP 474 EP 480 DI 10.1016/S2213-8587(14)70057-9 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA AI2YE UT WOS:000336724300024 PM 24731674 ER PT J AU Domingues, CMAS Verani, JR Renoiner, EIM Brandileone, MCD Flannery, B de Oliveira, LH Santos, JB de Moraes, JC AF Domingues, Carla Magda Allan S. Verani, Jennifer R. Montenegro Renoiner, Ernesto Issac de Cunto Brandileone, Maria Cristina Flannery, Brendan de Oliveira, Lucia Helena Santos, Joao Barberino de Moraes, Jose Cassio CA Brazilian Pneumococcal Conjugate TI Effectiveness of ten-valent pneumococcal conjugate vaccine against invasive pneumococcal disease in Brazil: a matched case-control study SO LANCET RESPIRATORY MEDICINE LA English DT Article ID STREPTOCOCCUS-PNEUMONIAE; PHID-CV; ANTIMICROBIAL RESISTANCE; CHILDREN; IMMUNOGENICITY; IMPACT; SEROTYPES; CARRIAGE; COVERAGE; BURDEN AB Background In March 2010, Brazil introduced the ten-valent pneumococcal conjugate vaccine (PCV10), which was licensed based on non-inferiority of immunological correlates of protection compared with the seven-valent vaccine. The schedule comprised three primary doses at ages 2 months, 4 months, and 6 months, and a booster dose at age 12 months. A single catch-up dose was offered for children aged 12-23 months at the time of introduction. We assessed PCV10 effectiveness against invasive pneumococcal disease in Brazilian children. Methods Invasive pneumococcal disease, defined as isolation of Streptococcus pneumoniae from blood, cerebrospinal fluid, or another normally sterile site, was identified in children age-eligible for at least one PCV10 dose through laboratory-based and hospital-based surveillance in ten states in Brazil from March 1, 2010, until Dec 31, 2012. We aimed to identify four age-matched and neighbourhood-matched controls for each case. We used conditional logistic regression and calculated PCV10 effectiveness as (1-adjusted matched odds ratio) x 100% for vaccine-type and vaccine-related serotypes (ie, in the same serogroup as a vaccine serotype). Findings In 316 cases (median age 13.2 months, range 2.6-53.1) and 1219 controls (13.3 months, 2.6-53.1), the adjusted effectiveness of an age-appropriate PCV10 schedule was 83.8% (95% CI 65.9-92.3) against vaccine serotypes, and 77.9% (41.0-91.7) against vaccine-related serotypes. Serotype-specific effectiveness was shown for the two most common vaccine serotypes-14 (87.7%, 60.8-96.1) and 6B (82.8%, 23.8-96.1)-and serotype 19A (82.2%, 10.7-96.4), a serotype related to vaccine serotype 19F. A single catch-up dose in children aged 12-23 months was effective against vaccine-type disease (68.0%, 17.6-87.6). No significant effectiveness was shown against non-vaccine serotypes for age-appropriate or catch-up schedules. Interpretation In the routine immunisation programme in Brazil, PCV10 prevents invasive disease caused by vaccine serotypes. PCV10 might provide cross-protection against some vaccine-related serotypes. C1 [Domingues, Carla Magda Allan S.; Montenegro Renoiner, Ernesto Issac] Minist Hlth, Natl Immunizat Program, Secretariat Hlth Surveillance, Brasilia, DF, Brazil. [Domingues, Carla Magda Allan S.; Santos, Joao Barberino] Univ Brasilia, Ctr Trop Med, Brasilia, DF, Brazil. [Verani, Jennifer R.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [de Cunto Brandileone, Maria Cristina] Secretary Hlth State Sao Paulo, Natl Reference Lab Meningitis & Pneumococcal Infe, Bacteriol Ctr, Adolfo Lutz Inst, Sao Paulo, Brazil. [Flannery, Brendan] Pan Amer Hlth Org, Brasilia, DF, Brazil. [de Oliveira, Lucia Helena] Pan Amer Hlth Org, Washington, DC USA. [de Moraes, Jose Cassio] Sch Med Sci Santa Casa, Dept Social Med, Sao Paulo, Brazil. RP Domingues, CMAS (reprint author), Programa Nacl Imunizacoes, Brasilia, DF, Brazil. EM carla.domingues@saude.gov.br FU Brazilian Ministry of Health; Pan American Health Organization FX Surveillance of invasive pneumococcal disease was funded by the Brazilian Ministry of Health, with support from the Pan American Health Organization. Support for the national reference laboratory for invasive bacterial diseases was provided by the Pan American Health Organization through the regional surveillance for new vaccines (SIREVA II) project. We thank the children and their parents whose participation made this study possible; surveillance units, hospital staff, meningitis and pneumonia surveillance personnel, and public health laboratory staff at the local, state, and federal levels; and Cyndy Whitney (US Centers for Disease Control and Prevention) for valuable input to the manuscript. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 29 TC 53 Z9 55 U1 0 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 2213-2600 J9 LANCET RESP MED JI Lancet Resp. Med. PD JUN PY 2014 VL 2 IS 6 BP 464 EP 471 DI 10.1016/S2213-2600(14)70060-8 PG 8 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA AI2WA UT WOS:000336717900017 PM 24726406 ER PT J AU Holman, DM Berkowitz, Z Guy, GP Hartman, AM Perna, FM AF Holman, Dawn M. Berkowitz, Zahava Guy, Gery P., Jr. Hartman, Anne M. Perna, Frank M. TI The association between demographic and behavioral characteristics and sunburn among U.S. adults - National Health Interview Survey, 2010 SO PREVENTIVE MEDICINE LA English DT Article DE Sunburn; Skin neoplasms; Primary prevention; Health behavior; Adult ID SKIN-CANCER RISK; CUTANEOUS MALIGNANT-MELANOMA; UNITED-STATES; SUN PROTECTION; WOMEN; METAANALYSIS; POPULATION; PREVALENCE; PREVENTION; SUNSCREEN AB Objective. To examine the association between demographic and behavioral characteristics and sunburn among U.S. adults. Method We used 2010 National Health Interview Survey data (N = 24,970) to conduct multivariable logistic regressions examining associations with having 1 or more sunburns in the past year and having 4 or more sunburns in the past year. Results. Overall, 37.1% of adults experienced sunburn in the past year. The adjusted prevalence of sunburn was particularly common among adults aged 18-29 years (52.0%), those who repeatedly burn or freckle after 2 weeks in the sun (45.9%), whites (443%), indoor tanners (44.1%), those with a family history of melanoma (43.9%), and those who are US-born (39.5%). Physical activity, alcohol consumption, and overweight/obesity were positively associated with sunburn (all P < 0.001); sun protection behaviors were not significantly associated with sunburn (P = 0.35). Among those who were sunburned in the past year, 12.1% experienced 4 or more sunburns. Conclusion. Sunburn is common, particularly among younger adults, those with a more sun-sensitive skin type, whites, those with a family history of melanoma, the highly physically active, and indoor tanners. Efforts are needed to facilitate sun-safety during outdoor recreation, improve the consistency of sun protection practices, and prevent sunburn, particularly among these subgroups. Published by Elsevier Inc. C1 [Holman, Dawn M.; Berkowitz, Zahava; Guy, Gery P., Jr.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA 30341 USA. [Hartman, Anne M.; Perna, Frank M.] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. RP Holman, DM (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, 4770 Buford Highway,NE Chamblee Bldg 107,MS F76, Atlanta, GA 30341 USA. EM dholman@cdc.gov; zab3@cdc.gov; irm2@cdc.gov; hartmana@mail.nih.gov; pernafm@mail.nih.gov FU Intramural CDC HHS [CC999999] NR 39 TC 22 Z9 22 U1 4 U2 16 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0091-7435 EI 1096-0260 J9 PREV MED JI Prev. Med. PD JUN PY 2014 VL 63 BP 6 EP 12 DI 10.1016/j.ypmed.2014.02.018 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA AI0TM UT WOS:000336562900002 PM 24589442 ER PT J AU Pesko, MF Xu, X Tynan, MA Gerzoff, RB Malarcher, AM Pechacek, TF AF Pesko, Michael F. Xu, Xin Tynan, Michael A. Gerzoff, Robert B. Malarcher, Ann M. Pechacek, Terry F. TI Per-pack price reductions available from different cigarette purchasing strategies: United States, 2009-2010 SO PREVENTIVE MEDICINE LA English DT Article DE Price reduction; Cigarette purchasing strategy; United States ID 4 COUNTRY SURVEY; MINIMIZATION STRATEGIES; SMOKING-CESSATION; TOBACCO USE; BEHAVIORS; SMOKERS; TAXES; PATTERNS; INTERNET AB Objective. Following cigarette excise tax increases, smokers may use cigarette price minimization strategies to continue their usual cigarette consumption rather than reducing consumption or quitting. This reduces the public health benefits of the tax increase. This paper estimates the price reductions for a wide-range of strategies, compensating for overlapping strategies. Method. We performed regression analysis on the 2009-2010 National Adult Tobacco Survey (N = 13,394) to explore price reductions that smokers in the United States obtained from purchasing cigarettes. We examined five cigarette price minimization strategies: 1) purchasing discount brand cigarettes, 2) using price promotions, 3) purchasing cartons, 4) purchasing on Indian reservations, and 5) purchasing online. Price reductions from these strategies were estimated jointly to compensate for overlapping strategies. Results. Each strategy provided price reductions between 26 and 99 cents per pack. Combined price reductions were possible. Additionally, price promotions were used with regular brands to obtain larger price reductions than when price promotions were used with generic brands. Conclusion. Smokers can realize large price reductions from price minimization strategies, and there are many strategies available. Policymakers and public health officials should be aware of the extent that these strategies can reduce cigarette prices. Published by Elsevier Inc. C1 [Pesko, Michael F.] Cornell Univ, Weill Cornell Med Coll, Dept Healthcare Policy & Res, New York, NY 10065 USA. [Xu, Xin; Gerzoff, Robert B.; Malarcher, Ann M.; Pechacek, Terry F.] Ctr Dis Control & Prevent, Off Smoking & Hlth, Atlanta, GA 30341 USA. [Tynan, Michael A.] Oregon Hlth Author, Publ Hlth Div, Portland, OR 97232 USA. RP Xu, X (reprint author), Ctr Dis Control & Prevent, Off Smoking & Hlth, 4770 Buford Highway,Mailstop K-50, Atlanta, GA 30341 USA. EM xinxu@cdc.gov FU Research Participation Program at the Centers for Disease Control and Prevention (CDC); U.S. Department of Energy [DE-AC05-06OR23100]; CDC [DE-AC05-06OR23100] FX This project was supported in part by an appointment to the Research Participation Program at the Centers for Disease Control and Prevention (CDC) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the CDC (Grant DE-AC05-06OR23100). NR 28 TC 5 Z9 5 U1 3 U2 11 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0091-7435 EI 1096-0260 J9 PREV MED JI Prev. Med. PD JUN PY 2014 VL 63 BP 13 EP 19 DI 10.1016/j.ypmed.2014.02.017 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA AI0TM UT WOS:000336562900003 PM 24594102 ER PT J AU Haderxhanaj, LT Leichliter, JS Aral, SO Chesson, HW AF Haderxhanaj, Laura T. Leichliter, Jami S. Aral, Sevgi O. Chesson, Harrell W. TI Sex in a Lifetime: Sexual Behaviors in the United States by Lifetime Number of Sex Partners, 2006-2010 SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID MODEL-BASED ANALYSIS; TRANSMITTED-DISEASES; HEALTH; WOMEN; AGE; US AB Using data from the 2006-2010 National Survey of Family Growth, we found that lifetime number of vaginal sex partners is positively associated with the number of sex partners in the past 12 months and negatively associated with age at first vaginal intercourse among 15- to 44-year-old male and female respondents. C1 [Haderxhanaj, Laura T.; Leichliter, Jami S.; Aral, Sevgi O.; Chesson, Harrell W.] Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. RP Haderxhanaj, LT (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, 1600 Clifton Rd,Mailstop E-02, Atlanta, GA 30333 USA. EM LHaderxhanaj@cdc.gov FU US Department of Energy; Centers for Disease Control and Prevention FX This research was supported in part by an appointment to the Research Participation Program at the Centers for Disease Control and Prevention administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and Centers for Disease Control and Prevention. NR 25 TC 1 Z9 1 U1 1 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 IS 6 BP 345 EP 352 DI 10.1097/OLQ.0000000000000132 PG 8 WC Infectious Diseases SC Infectious Diseases GA AI2EA UT WOS:000336669000001 PM 24825330 ER PT J AU Hoots, BE Lewis, FMT Anschuetz, G Schillinger, JA Blank, S Foskey, T Stover, JA Peterman, TA AF Hoots, Brooke E. Lewis, Felicia M. T. Anschuetz, Greta Schillinger, Julia A. Blank, Susan Foskey, Tammy Stover, Jeffrey A. Peterman, Thomas A. TI Would Targeting Increase Efficiency of Syphilis Partner Services Programs?-Data From New York City, Philadelphia, Texas, and Virginia SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID CASE-FINDING EFFECTIVENESS; NOTIFICATION; MEN; SEX; ATTITUDES; COSTS; HIV AB Background: Targeted partner notification (PN), or limiting PN to groups in which efforts are most successful, has been suggested as a potentially cost-effective alternative to providing PN for all syphilis case-patients. The purpose of this study was to identify index case characteristics associated with highest yield partner elicitation and subsequent case finding to determine whether some groups could be reasonably excluded from PN efforts. Methods: We examined index case characteristics and PN metrics from syphilis case management records of 4 sexually transmitted disease control programs-New York City, Philadelphia, Texas, and Virginia. Partner elicitation was considered successful when a case-patient named 1 or more partners during interview. Case finding was considered successful when a case-patient had 1 or more partners who were tested and had serologic evidence of syphilis exposure. Associations between case characteristics and proportion of pursued case-patients with successful partner elicitation and case finding were evaluated using chi(2) tests. Results: Successful partner elicitation and new case finding was most likely for index case-patients who were younger and diagnosed at public sexually transmitted disease clinics. However, most characteristics of index case-patients were related to success at only a few sites, or varied in the direction of the relationship by site. Other than late latent case-patients, few demographic groups had a yield far below average. Conclusions: If implemented, targeted PN will require site-specific data. Sites may consider eliminating PN for late latent case-patients. The lack of demographic groups with a below average yield suggests that sites should not exclude other groups from PN. C1 [Hoots, Brooke E.; Lewis, Felicia M. T.; Schillinger, Julia A.; Blank, Susan; Peterman, Thomas A.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30329 USA. [Hoots, Brooke E.] Epidem Intelligence Serv, Sci Educ & Profess Dev Program Off, Div Appl Sci, Atlanta, GA USA. [Lewis, Felicia M. T.; Anschuetz, Greta] Philadelphia Dept Publ Hlth, Philadelphia, PA USA. [Schillinger, Julia A.; Blank, Susan] New York City Dept Hlth & Mental Hyg, New York, NY USA. [Foskey, Tammy] Texas Dept State Hlth Serv, HIV STD Prevent & Care Branch, Austin, TX USA. [Stover, Jeffrey A.] Virginia Dept Hlth, Div Dis Prevent, Richmond, VA USA. RP Hoots, BE (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, 1600 Clifton Rd NE,Mailstop E-46, Atlanta, GA 30329 USA. EM bhoots@cdc.gov FU Intramural CDC HHS [CC999999] NR 18 TC 5 Z9 5 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 IS 6 BP 407 EP 412 DI 10.1097/OLQ.0000000000000130 PG 6 WC Infectious Diseases SC Infectious Diseases GA AI2EA UT WOS:000336669000012 PM 24825340 ER PT J AU Lehman, JS Carr, MH Nichol, AJ Ruisanchez, A Knight, DW Langford, AE Gray, SC Mermin, JH AF Lehman, J. Stan Carr, Meredith H. Nichol, Allison J. Ruisanchez, Alberto Knight, David W. Langford, Anne E. Gray, Simone C. Mermin, Jonathan H. TI Prevalence and Public Health Implications of State Laws that Criminalize Potential HIV Exposure in the United States SO AIDS AND BEHAVIOR LA English DT Review DE HIV prevention; HIV-specific criminal laws; Public health law research; Public health policy; Structural interventions; State laws ID PREVENTION; DISCLOSURE; TRANSMISSION; ATTITUDES; IMPACT; MEN AB For the past three decades, legislative approaches to prevent HIV transmission have been used at the national, state, and local levels. One punitive legislative approach has been enactment of laws that criminalize behaviors associated with HIV exposure (HIV-specific criminal laws). In the USA, HIV-specific criminal laws have largely been shaped by state laws. These laws impose criminal penalties on persons who know they have HIV and subsequently engage in certain behaviors, most commonly sexual activity without prior disclosure of HIV-positive serostatus. These laws have been subject to intense public debate. Using public health law research methods, data from the legal database WestlawNextA (c) were analyzed to describe the prevalence and characteristics of laws that criminalize potential HIV exposure in the 50 states (plus the District of Columbia) and to examine the implications of these laws for public health practice. The first state laws were enacted in 1986; as of 2011 a total of 67 laws had been enacted in 33 states. By 1995, nearly two-thirds of all laws had been enacted; by 2000, 85 % of laws had been enacted; and since 2000, an additional 10 laws have been enacted. Twenty-four states require persons who are aware that they have HIV to disclose their status to sexual partners and 14 states require disclosure to needle-sharing partners. Twenty-five states criminalize one or more behaviors that pose a low or negligible risk for HIV transmission. Nearly two-thirds of states in the USA have legislation that criminalizes potential HIV exposure. Many of these laws criminalize behaviors that pose low or negligible risk for HIV transmission. The majority of laws were passed before studies showed that antiretroviral therapy (ART) reduces HIV transmission risk and most laws do not account for HIV prevention measures that reduce transmission risk, such as condom use, ART, or pre-exposure prophylaxis. States with HIV-specific criminal laws are encouraged to use the findings of this paper to re-examine those laws, assess the laws' alignment with current evidence regarding HIV transmission risk, and consider whether the laws are the best vehicle to achieve their intended purposes. C1 [Lehman, J. Stan; Carr, Meredith H.; Gray, Simone C.; Mermin, Jonathan H.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Carr, Meredith H.] ORISE, Atlanta, GA USA. [Nichol, Allison J.; Ruisanchez, Alberto; Knight, David W.; Langford, Anne E.] US Dept Justice, Civil Rights Div, Washington, DC 20530 USA. RP Lehman, JS (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, 1600 Clifton Rd,MS D21, Atlanta, GA 30333 USA. EM slehman@cdc.gov NR 33 TC 27 Z9 27 U1 1 U2 9 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1090-7165 EI 1573-3254 J9 AIDS BEHAV JI AIDS Behav. PD JUN PY 2014 VL 18 IS 6 BP 997 EP 1006 DI 10.1007/s10461-014-0724-0 PG 10 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA AH5YF UT WOS:000336206400001 PM 24633716 ER PT J AU Jenkins, MM Reefhuis, J Gallagher, ML Mulle, JG Hoffmann, TJ Koontz, DA Sturchio, C Rasmussen, SA Witte, JS Richter, P Honein, MA AF Jenkins, Mary M. Reefhuis, Jennita Gallagher, Margaret L. Mulle, Jennifer G. Hoffmann, Thomas J. Koontz, Deborah A. Sturchio, Cynthia Rasmussen, Sonja A. Witte, John S. Richter, Patricia Honein, Margaret A. CA Natl Birth Defects Prevention TI Maternal smoking, xenobiotic metabolizing enzyme gene variants, and gastroschisis risk SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A LA English DT Article DE maternal smoking; CYP; NAT; genetic epidemiology; risk factors; gastroschisis ID BIRTH-DEFECTS; TOBACCO-SMOKE; UNITED-STATES; WALL DEFECTS; POLYMORPHISMS; CAFFEINE; PREVALENCE; EXPOSURE; CYP1A1; NAT2 AB Maternal smoking during pregnancy is one proposed risk factor for gastroschisis, but reported associations have been modest, suggesting that differences in genetic susceptibility might play a role. We included 108 non-Hispanic white and 62 Hispanic families who had infants with gastroschisis, and 1,147 non-Hispanic white and 337 Hispanic families who had liveborn infants with no major structural birth defects (controls) in these analyses. DNA was extracted from buccal cells collected from infants and mothers, and information on periconceptional smoking history was obtained from maternal interviews, as part of the National Birth Defects Prevention Study. We analyzed five polymorphisms in three genes that code for enzymes involved in metabolism of some cigarette smoke constituents (CYP1A1, CYP1A2, and NAT2). Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) independently for maternal smoking and maternal and infant gene variants, and to assess joint associations of maternal smoking and maternal or infant gene variants with gastroschisis. In analyses adjusted for maternal age at delivery and stratified by maternal race-ethnicity, we identified three suggestive associations among 30 potential associations with sufficient numbers to calculate ORs: CYP1A1*2A for non-Hispanic white mothers who smoked periconceptionally (aOR = 0.38, 95% CI 0.15-0.98), and NAT2*6 for Hispanic non-smoking mothers (aOR = 2.17, 95% CI 1.12-4.19) and their infants (aOR = 2.11, 95% CI 1.00-4.48). This analysis does not support the occurrence of effect modification between periconceptional maternal smoking and most of the xenobiotic metabolizing enzyme gene variants assessed. (c) 2014 Wiley Periodicals, Inc. C1 [Jenkins, Mary M.; Reefhuis, Jennita; Gallagher, Margaret L.; Koontz, Deborah A.; Rasmussen, Sonja A.; Richter, Patricia; Honein, Margaret A.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Mulle, Jennifer G.] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Hoffmann, Thomas J.; Witte, John S.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. [Hoffmann, Thomas J.; Witte, John S.] Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94143 USA. [Sturchio, Cynthia] Battelle Ctr Publ Hlth Res & Evaluat, Columbus, OH USA. RP Jenkins, MM (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,M-S E-86, Atlanta, GA 30333 USA. EM mmjenkins@cdc.gov FU CDC's National Office of Public Health Genomics FX Grant sponsor: CDC's National Office of Public Health Genomics. NR 45 TC 4 Z9 4 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1552-4825 EI 1552-4833 J9 AM J MED GENET A JI Am. J. Med. Genet. A PD JUN PY 2014 VL 164 IS 6 BP 1454 EP 1463 DI 10.1002/ajmg.a.36478 PG 10 WC Genetics & Heredity SC Genetics & Heredity GA AH2BV UT WOS:000335926600013 PM 24668907 ER PT J AU Lairson, DR Chang, YC Byrd, TL Smith, JL Fernandez, ME Wilson, KM AF Lairson, David R. Chang, Yu-Chia Byrd, Theresa L. Smith, Judith Lee Fernandez, Maria E. Wilson, Katherine M. TI Cervical Cancer Screening with AMIGAS A Cost-Effectiveness Analysis SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID HISPANIC WOMEN; INTERVENTION; BREAST; SERVICES; STATES AB Background: Hispanic women have a higher incidence of cervical cancer than all other races and ethnicities. In Hispanic subgroups, Mexican American women were among the least likely to have received cervical cancer screening. In a recent RCT, Ayudando a las Mujeres con Informacion, Guia, y Amor para su Salud (AMIGAS) was shown to increase cervical cancer screening rates among women of Mexican descent at 6 months in all intervention arms compared to the control arm. Limited information exists about the economics of interventions to increase cervical cancer screening rates among women of Mexican descent. Purpose: This study aims to estimate the cost-effectiveness of the alternative AMIGAS intervention methods for increasing cervical cancer screening among low-income women of Mexican descent in three U.S. communities. Methods: Cost data were collected from 2008 to 2011 alongside the AMIGAS study of 613 women. Receipt of Pap test within 6 months of intervention was the primary outcome measure in the cost-effectiveness analysis, conducted during 2012-2013. Results: The cost per additional woman screened comparing the video-only intervention to usual care was $980. The cost increased to $1,309 with participant time cost included. With an additional cost per participant of $3.90 compared to flipchart only, the full AMIGAS program (video plus flipchart) yielded 6.8% additional women screened. Conclusions: Results on the average and incremental cost-effectiveness of the AMIGAS program elements may assist health policymakers and program managers to select and appropriately budget for interventions shown to increase cervical cancer screening among low-income women of Mexican descent. (C) 2014 American Journal of Preventive Medicine. All rights reserved. C1 [Lairson, David R.; Chang, Yu-Chia; Fernandez, Maria E.] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Houston, TX 77030 USA. [Fernandez, Maria E.] Univ Texas Hlth Sci Ctr Houston, Ctr Hlth Promot & Prevent Res, Houston, TX 77030 USA. [Byrd, Theresa L.] Texas Tech Univ, Paul L Foster Sch Med, Lubbock, TX 79409 USA. [Smith, Judith Lee] CDC, Div Canc Prevent & Control, Atlanta, GA 30333 USA. [Wilson, Katherine M.] CDC, Epidemiol & Anal Program Off, Atlanta, GA 30333 USA. RP Lairson, DR (reprint author), Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, 1200 Herman Pressler, Houston, TX 77030 USA. EM david.r.lairson@uth.tmc.edu FU CDC [U48-DP000057] FX Research for this publication was supported by the CDC cooperative agreement U48-DP000057 to the University of Texas, School of Public Health at El Paso. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the CDC. NR 37 TC 2 Z9 2 U1 1 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD JUN PY 2014 VL 46 IS 6 BP 617 EP 623 DI 10.1016/j.amepre.2014.01.020 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA AH5SC UT WOS:000336190400009 PM 24842738 ER PT J AU McNicholl, JM Henning, TC Vishwanathan, SA Kersh, EN AF McNicholl, Janet M. Henning, Tara C. Vishwanathan, Sundaram A. Kersh, Ellen N. TI Non-Human Primate Models of Hormonal Contraception and HIV SO AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY LA English DT Article DE Acquisition risk; immune; macaque; progesterone; simian immunodeficiency viruses (SIV); SIVs expressing HIV genes ID HUMAN-IMMUNODEFICIENCY-VIRUS; SEXUALLY-TRANSMITTED-DISEASES; FEMALE REPRODUCTIVE-TRACT; SIV VAGINAL TRANSMISSION; PIG-TAILED MACAQUES; RHESUS MACAQUES; MACACA-NEMESTRINA; MENSTRUAL-CYCLE; ANIMAL-MODELS; SIMIAN-HUMAN AB ProblemRecent concerns that hormonal contraception (HC) may increase risk of HIV acquisition has led to keen interest in using non-human primates (NHP) to understand the underlying mechanism and the magnitude of the risk. This is, in part, because some experiments which would be difficult or logistically impossible in women are more easily conducted in NHP. Method of studyNHP models of HIV can inform HIV acquisition and pathogenesis research and identify and evaluate biomedical preventions and treatments for HIV/AIDS. Widely used species include rhesus, pigtail, and cynomolgous macaques. ResultsThis paper reviews past, current and proposed NHP research around the intersection of HIV and HC. ConclusionNHP research may lead to the identification of hormonally regulated biomarkers that correlate with HIV-acquisition risk, to a ranking of existing or next-generation HC along an HIV-acquisition risk profile, and inform research around new biomedical preventions for HIV. C1 [McNicholl, Janet M.; Henning, Tara C.; Vishwanathan, Sundaram A.; Kersh, Ellen N.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30329 USA. RP McNicholl, JM (reprint author), Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, MS A25, Atlanta, GA 30329 USA. EM jkm7@cdc.gov FU CDC; CDC [AAI 12041]; NIH/NIAID [AAI 12041] FX We thank David Garber and Mark Lewis for assistance with Table II and for helpful comments on the manuscript. Prachi Sharma and Ai Tsuki helped with vaginal histology. Some of the work cited in this article was funded by CDC and by an Interagency Agreement AAI 12041 between CDC and NIH/NIAID. NR 89 TC 10 Z9 10 U1 0 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1046-7408 EI 1600-0897 J9 AM J REPROD IMMUNOL JI Am. J. Reprod. Immunol. PD JUN PY 2014 VL 71 IS 6 SI SI BP 513 EP 522 DI 10.1111/aji.12246 PG 10 WC Immunology; Reproductive Biology SC Immunology; Reproductive Biology GA AH1YK UT WOS:000335917600005 PM 24716832 ER PT J AU Schwebel, DC Lewis, T Simon, TR Elliott, MN Toomey, SL Tortolero, SR Cuccaro, PM Schuster, MA AF Schwebel, David C. Lewis, Terri Simon, Thomas R. Elliott, Marc N. Toomey, Sara L. Tortolero, Susan R. Cuccaro, Paula M. Schuster, Mark A. TI Prevalence and Correlates of Firearm Ownership in the Homes of Fifth Graders: Birmingham, AL, Houston, TX, and Los Angeles, CA SO HEALTH EDUCATION & BEHAVIOR LA English DT Article DE firearms; guns; injury; safety ID STORAGE PRACTICES; HOUSEHOLD FIREARMS; PEDIATRIC POPULATION; CHILDREN; RISK; INJURIES; ADOLESCENTS; DISPARITIES; PATTERNS; ACCESS AB Firearms in the home are associated with increased injury risk, especially when loaded and unlocked. In this study, 5,010 fifth-graders and their caregivers in three U.S. metropolitan areas participated in the 2004-2006 Healthy Passages study on adolescent health. Firearm ownership and storage patterns were examined by four self-reported sociodemographic characteristics (child's race/ethnicity, child's gender, family socioeconomic status, and study site) and reasons for ownership. Eighteen percent (n = 880) of the families reported firearms in the home. Families with African American and Hispanic children had lower odds of owning firearms than families with non-Hispanic White children. The most common reasons for ownership were protection from crime and hunting. Six percent (n = 56) of the families with firearms stored at least one firearm unlocked, assembled, without a trigger lock, and with unlocked ammunition. Compared with families with non-Hispanic White children, families with African American children engaged in safer storage practices. Results can inform childhood firearm injury prevention activities. C1 [Schwebel, David C.; Lewis, Terri] Univ Alabama Birmingham, Birmingham, AL 35294 USA. [Simon, Thomas R.] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA. [Elliott, Marc N.; Schuster, Mark A.] RAND Corp, Santa Monica, CA USA. [Toomey, Sara L.; Schuster, Mark A.] Boston Childrens Hosp, Div Gen Pediat, Boston, MA USA. [Toomey, Sara L.; Schuster, Mark A.] Harvard Univ, Sch Med, Boston, MA USA. [Tortolero, Susan R.; Cuccaro, Paula M.] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA. RP Schwebel, DC (reprint author), Univ Alabama Birmingham, Dept Psychol, 1300 Univ Blvd,HHB 571, Birmingham, AL 35294 USA. EM schwebel@uab.edu OI Cuccaro, Paula/0000-0002-9551-4789 FU Intramural CDC HHS [CC999999]; NCCDPHP CDC HHS [U19DP002663, U19 DP002663, U19 DP002664, U19 DP002665, U19DP002664, U19DP002665] NR 30 TC 2 Z9 2 U1 2 U2 7 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1090-1981 EI 1552-6127 J9 HEALTH EDUC BEHAV JI Health Educ. Behav. PD JUN PY 2014 VL 41 IS 3 BP 299 EP 306 DI 10.1177/1090198113512126 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AH6DW UT WOS:000336221900008 PM 24419969 ER PT J AU Nguyen, DC Sanghvi, R Scinicariello, F Pulit-Penaloza, J Hill, N Attanasio, R AF Nguyen, Doan C. Sanghvi, Rashesh Scinicariello, Franco Pulit-Penaloza, Joanna Hill, Nicole Attanasio, Roberta TI Cynomolgus and pigtail macaque IgG subclasses: characterization of IGHG genes and computational analysis of IgG/Fc receptor binding affinity SO IMMUNOGENETICS LA English DT Article DE IGHG genes; Nonhuman primate (NHP); Macaque; Macfas; Macnem; IMGT ID FC-GAMMA-RI; PRE-B-CELLS; RHESUS MACAQUES; IMMUNOGLOBULIN; REGION; SITE; ANTIBODY; IDENTIFICATION; HETEROGENEITY; COMPLEMENT AB Macaques are the most widely used experimental nonhuman primate (NHP) species. Rhesus (Macaca mulatta, Macmul), cynomolgus (Macaca fascicularis, Macfas), and pigtail (Macaca nemestrina, Macnem) macaques continue to be popular models for vaccine and infectious diseases research, especially HIV infection and AIDS, and for the development of antibody-based therapeutic strategies. Increased understanding of the immune system of these species is necessary for their optimal use as models of human infections and intervention. In the past few years, the antibody/Fc receptor system has been characterized in a stepwise manner in these species. We have continued this characterization by identifying the four IG heavy gamma (IGHG) genes of Macfas and Macnem in this study. Our results show that these genes share a high degree of similarity with those from other NHP species, while presenting consistent differences when compared to human IGHG genes. Furthermore, comparison of Macfas IGHG genes with those described in other studies suggests the existence of polymorphism. Using sequence- and structure-based computational tools, we performed in silico analysis on multiple polymorphic Macfas IgG and their interactions with human IgG Fc receptors (Fc gamma R), thus predicting that Macfas IGHG polymorphisms influence IgG protein stability and/or binding affinity towards Fc gamma R. The presence of macaque IGHG polymorphisms and macaque/human amino acid changes at locations potentially involved in antibody functional properties indicate the need for cautious design and data interpretation of studies in these models, possibly requiring the characterization of antibody/Fc receptor interactions at the individual level. C1 [Nguyen, Doan C.; Sanghvi, Rashesh; Pulit-Penaloza, Joanna; Hill, Nicole; Attanasio, Roberta] Georgia State Univ, Dept Biol, Atlanta, GA 30303 USA. [Scinicariello, Franco] Ctr Dis Control & Prevent, Div Toxicol & Environm Med, Agcy Tox Subst & Dis Registry, Atlanta, GA 30333 USA. RP Attanasio, R (reprint author), Georgia State Univ, Dept Biol, POB 4010, Atlanta, GA 30303 USA. EM rattanasio@gsu.edu FU NIH [R21 AI078855]; Research Program Enhancement from the Georgia State University Office of Research and Sponsored Programs; Georgia Research Alliance; Molecular Basis of Disease (MBD) program at Georgia State University FX This work was supported in part by NIH grant R21 AI078855, by the Research Program Enhancement from the Georgia State University Office of Research and Sponsored Programs, and by the Georgia Research Alliance. Support for Doan C. Nguyen was provided by the Molecular Basis of Disease (MBD) program at Georgia State University. NR 45 TC 5 Z9 5 U1 1 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0093-7711 EI 1432-1211 J9 IMMUNOGENETICS JI Immunogenetics PD JUN PY 2014 VL 66 IS 6 BP 361 EP 377 DI 10.1007/s00251-014-0775-4 PG 17 WC Genetics & Heredity; Immunology SC Genetics & Heredity; Immunology GA AH6VM UT WOS:000336270000002 PM 24811270 ER PT J AU Shepardson, D Mac Kenzie, WR AF Shepardson, Dylan Mac Kenzie, William R. TI Update on cost-effectiveness of a 12-dose regimen for latent tuberculous infection at new rifapentine prices SO INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE LA English DT Letter C1 [Shepardson, Dylan] Mt Holyoke Coll, S Hadley, MA 01075 USA. [Mac Kenzie, William R.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Shepardson, D (reprint author), Mt Holyoke Coll, S Hadley, MA 01075 USA. EM wrm0@cdc.gov NR 3 TC 6 Z9 6 U1 1 U2 1 PU INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) PI PARIS PA 68 BOULEVARD SAINT-MICHEL,, 75006 PARIS, FRANCE SN 1027-3719 EI 1815-7920 J9 INT J TUBERC LUNG D JI Int. J. Tuberc. Lung Dis. PD JUN PY 2014 VL 18 IS 6 BP 751 EP 751 DI 10.5588/ijtld.14.0052 PG 1 WC Infectious Diseases; Respiratory System SC Infectious Diseases; Respiratory System GA AH5VH UT WOS:000336198700022 PM 24903950 ER PT J AU York, L Janet, L Lanasa, S AF York, Liz Janet, Laura Lanasa, Suzanne TI Go Green, Get Healthy: An Agencywide Effort to Reduce Energy Use and Move the Centers for Disease Control and Prevention toward Sustainability SO JOURNAL OF ENERGY ENGINEERING LA English DT Article DE Centers for Disease Control and Prevention; Healthy environment; Energy consumption; Sustainable behaviors; Carbon footprint; Greenhouse gas; Power management; Alternative energy; Healthier worksite; Environmental stewardship ID CONSERVATION; INFORMATION; PSYCHOLOGY AB Americans look to the Centers for Disease Control and Prevention (CDC) to lead by providing an example of healthy people in healthy environments. Recognizing the synergy between environmental health and personal health and well-being, the CDC formed the Go Green, Get Healthy (GGGH) initiative. The GGGH rolls healthier worksite initiatives, quality-of-work-life programs, and internal environmental protection efforts into a coordinated campaign for widespread cultural change with energy conservation as one of the major goals. The CDC hopes that this success will be a model for other agencies and organizations. The Office of Sustainability at the CDC actively engages the entire agency in environmental stewardship and specifically, energy conservation (in the GGGH initiative) by providing a vision with leadership support, education for every individual, effective communication methods, and a robust tracking system for comprehensive data and feedback. The campaign works effectively by breaking down the task of greening the agency into sectors. Each sector needs support of CDC leadership and work of responsible offices, complimented by the grassroots dedication of individuals in the GGGH workgroups and collaborative external partnerships. Several low/no-cost examples are included to demonstrate progress toward a sustainable CDC and these can be used to help other organizations discover a greener and healthier model for their sustainability and conservation efforts with a minimal outlay of funds. Through physical changes, culture changes, and policy/operational changes, energy and water can be saved. This paper seeks to convey the following main learning points: (1)identify low/no-cost ways to reduce energy and water consumption; (2)describe ways to influence workers to adopt more sustainable behaviors; and (3)discuss ways to integrate energy-management decision-making processes and standard operating procedures. (C) 2013 American Society of Civil Engineers. C1 [York, Liz; Janet, Laura; Lanasa, Suzanne] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Lanasa, S (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. EM SLanasa@cdc.gov NR 10 TC 0 Z9 0 U1 2 U2 14 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9402 EI 1943-7897 J9 J ENERG ENG JI J. Energy Eng.-ASCE PD JUN PY 2014 VL 140 IS 2 DI 10.1061/(ASCE)EY.1943-7897.0000132 PG 7 WC Energy & Fuels; Engineering, Civil SC Energy & Fuels; Engineering GA AH6PD UT WOS:000336252100007 ER PT J AU Pelaez-Carvajal, D Cotes-Cantillo, K Paternina-Caicedo, A Gentsch, J de la Hoz-Restrepo, F Patel, M AF Pelaez-Carvajal, Dioselina Cotes-Cantillo, Karol Paternina-Caicedo, Angel Gentsch, Jon de la Hoz-Restrepo, Fernando Patel, Manish TI Characterization of Rotavirus Genotypes Before and After the Introduction of a Monovalent Rotavirus Vaccine in Colombia SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE rotavirus; vaccine; strains; serotype; diarrhea ID DIARRHEA; MEXICO; PROTECTION; STRAINS; BRAZIL AB Strain monitoring for emergence of novel strains after the introduction of rotavirus vaccine is an integral component of routine rotavirus immunization programs. Using a laboratory based strain surveillance system between 2008 and 2012, a wide variation in strain pattern in Colombia was founded both before and after the introduction of a monovalent rotavirus vaccine in 2009. G2P[4], a strain fully heterotypic to the vaccine was predominant before vaccine introduction in 2008 (47%) and after vaccine introduction in 2010 (54%), 2011 (86%), and 2012 (32%). The presence of this strain before the introduction of vaccine and decreasing prevalence during the most recent surveillance year suggests secular variation rather than vaccine pressure as a cause for this fluctuation. While strain monitoring can be valuable after vaccine introduction, these surveillance data alone without information on disease incidence or strain specific vaccine effectiveness can be prone to misinterpretation with regard to the role of vaccine pressure on emergence of new or persistent strains. J. Med. Virol. 86:1083-1086, 2014. (c) 2017 Wiley Periodicals, Inc. C1 [Pelaez-Carvajal, Dioselina; de la Hoz-Restrepo, Fernando] Natl Inst Hlth Colombia, Bogota, Colombia. [Cotes-Cantillo, Karol] Univ Nacl Colombia, Bogota, Colombia. [Paternina-Caicedo, Angel] Univ Cartagena, Cartagena De Indias, Colombia. [Gentsch, Jon; Patel, Manish] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Cotes-Cantillo, K (reprint author), Univ Nacl Colombia, Fac Med, Ciudad Univ,Fac Med Of 150, Bogota, Colombia. EM karpatri@hotmail.com RI Paternina-Caicedo, Angel/N-4496-2015 OI Paternina-Caicedo, Angel/0000-0002-6332-5174 FU National Institute of Health of Colombia; Administrative Department of Science Technology and Innovation of Colombia (COLCIENCIAS) FX Grant sponsor: National Institute of Health of Colombia; Grant sponsor: Administrative Department of Science Technology and Innovation of Colombia (COLCIENCIAS) NR 13 TC 4 Z9 4 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0146-6615 EI 1096-9071 J9 J MED VIROL JI J. Med. Virol. PD JUN PY 2014 VL 86 IS 6 BP 1083 EP 1086 DI 10.1002/jmv.23899 PG 4 WC Virology SC Virology GA AE1XX UT WOS:000333768200024 PM 24616018 ER PT J AU King, SC Pollack, LA Li, J King, JB Master, VA AF King, Sallyann Coleman Pollack, Lori A. Li, Jun King, Jessica B. Master, Viraj A. TI Continued Increase in Incidence of Renal Cell Carcinoma, Especially in Young Patients and High Grade Disease: United States 2001 to 2010 SO JOURNAL OF UROLOGY LA English DT Article DE kidney; carcinoma, renal cell; young adult; SEER program; epidemiology ID CIGARETTE-SMOKING; KIDNEY CANCER; RISK; NUTRITION; ADULTS; TRENDS; CARE AB Purpose: More than 50,000 Americans were diagnosed with kidney and renal pelvis cancer in 2010. The National Program of Cancer Registries and SEER (Surveillance, Epidemiology and End Results) combined data include cancer incidences from the entire United States. Our study presents updated incidence data, evaluates trends and adds geographic distribution to the literature. Materials and Methods: We examined invasive, microscopically confirmed kidney and renal pelvis cancers diagnosed from 2001 to 2010 that met United States Cancer Statistics reporting criteria for each year, excluding cases diagnosed by autopsy or death certificate. Histology codes classified cases as renal cell carcinoma. Rates and trends were estimated using SEER*Stat. Results: A total of 342,501 renal cell carcinoma cases were diagnosed. The renal cell carcinoma incidence rate increased from 10.6/100,000 individuals in 2001 to 12.4/100,000 in 2010 and increased with age until ages 70 to 74 years. The incidence rate in men was almost double that in women. The annual percent change was higher in women than in men, in those 20 to 24 years old and in grade III tumors. Conclusions: The annual percent change incidence increased from 2001 to 2010. Asian/Pacific Islanders and 20 to 24-year-old individuals had the highest annual percent change. While some increase resulted from localized disease, the highest annual percent change was in grade III tumors, indicating more aggressive disease. Continued monitoring of trends and epidemiological study are warranted to determine risk factors. C1 [Master, Viraj A.] Emory Univ, Ctr Dis Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Canc Prevent & Control, Atlanta, GA 30322 USA. [Master, Viraj A.] Emory Univ, Dept Urol, Atlanta, GA 30322 USA. [Master, Viraj A.] Emory Univ, Sch Med, Winship Canc Inst, Atlanta, GA USA. RP King, SC (reprint author), 4770 Buford Hwy Northeast,Mailstop F-72, Atlanta, GA 30341 USA. EM fjq9@cdc.gov FU Intramural CDC HHS [CC999999] NR 29 TC 29 Z9 33 U1 0 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 EI 1527-3792 J9 J UROLOGY JI J. Urol. PD JUN PY 2014 VL 191 IS 6 BP 1665 EP 1670 DI 10.1016/j.juro.2013.12.046 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA AI0IS UT WOS:000336531100008 PM 24423441 ER PT J AU Pettygrove, S Lu, ZQ Andrews, JG Meaney, FJ Sheehan, DW Price, ET Fox, DJ Pandya, S Ouyang, LJ Apkon, SD Powis, Z Cunniff, C AF Pettygrove, Sydney Lu, Zhenqiang Andrews, Jennifer G. Meaney, F. John Sheehan, Daniel W. Price, Elinora T. Fox, Deborah J. Pandya, Shree Ouyang, Lijing Apkon, Susan D. Powis, Zoe Cunniff, Christopher TI SIBLING CONCORDANCE FOR CLINICAL FEATURES OF DUCHENNE AND BECKER MUSCULAR DYSTROPHIES SO MUSCLE & NERVE LA English DT Article DE nerve conduction studies; electromyography; radiculopathy; F-waves; latency ID SCOLIOSIS; MANAGEMENT; SURVIVAL AB Introduction: The utility of F-waves in assessing radiculopathies is debated. The aim of this study is to determine the frequency of abnormal minimum tibial F-wave latencies compared to an F-estimate and an absolute reference value in patients with electromyography (EMG) confirmed S1 radiculopathies. Methods: A retrospective review of F-waves in patients with an EMG-confirmed isolated S1 radiculopathy was performed. The minimum and mean latencies of 8 tibial F-waves were compared with the calculated F-estimate and to an absolute reference value, and the frequencies of abnormal responses were determined. Results: Of the 50 patients with an S1 radiculopathy, 4% had prolongation of the minimum reproducible F-wave latency, and 8% had prolongation of the mean latency relative to the calculated F-estimate. Conclusions: The minimum and mean F-wave latencies are infrequently abnormal when compared with an estimated F-wave latency in S1 radiculopathies and are insensitive in the assessment of S1 nerve root injury. Muscle Nerve 49: 809-813, 2014 C1 [Pettygrove, Sydney] Univ Arizona, Coll Publ Hlth, Tucson, AZ 85724 USA. [Lu, Zhenqiang; Andrews, Jennifer G.; Meaney, F. John; Price, Elinora T.; Powis, Zoe; Cunniff, Christopher] Univ Arizona, Coll Med, Dept Pediat, Tucson, AZ 85724 USA. [Lu, Zhenqiang] Univ Arizona, Inst Bio5, Tucson, AZ 85724 USA. [Sheehan, Daniel W.] SUNY Buffalo, Dept Pediat, Buffalo, NY USA. [Fox, Deborah J.] New York State Dept Hlth, Albany, NY USA. [Pandya, Shree] Univ Rochester, Dept Neurol, Rochester, NY USA. [Ouyang, Lijing] Ctr Dis Control & Prevent, Atlanta, GA USA. [Apkon, Susan D.] Univ Washington, Dept Rehabil Med, Seattle, WA 98195 USA. RP Cunniff, C (reprint author), Univ Arizona, Coll Med, Dept Pediat, 1501 N Campbell Ave,Box 245073, Tucson, AZ 85724 USA. EM ccunniff@peds.arizona.edu FU Centers for Disease Control and Prevention [DD000187] FX This study was funded by the Centers for Disease Control and Prevention Cooperative Agreement DD000187 for Surveillance and Epidemiologic Research of Duchenne and Becker Muscular Dystrophy. The findings and conclusions in this report are those of the author(s) and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 17 TC 3 Z9 3 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0148-639X EI 1097-4598 J9 MUSCLE NERVE JI Muscle Nerve PD JUN PY 2014 VL 49 IS 6 BP 814 EP 821 DI 10.1002/mus.23992 PG 8 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA AH2MA UT WOS:000335954400005 PM 24030636 ER PT J AU Seth, P Kidder, D Pals, S Parent, J Mbatia, R Chesang, K Mbilinyi, D Koech, E Nkingwa, M Katuta, F Ng'ang'a, A Bachanas, P AF Seth, Puja Kidder, Daniel Pals, Sherri Parent, Julie Mbatia, Redempta Chesang, Kipruto Mbilinyi, Deogratius Koech, Emily Nkingwa, Mathias Katuta, Frieda Ng'ang'a, Anne Bachanas, Pamela TI Psychosocial Functioning and Depressive Symptoms Among HIV-Positive Persons Receiving Care and Treatment in Kenya, Namibia, and Tanzania SO PREVENTION SCIENCE LA English DT Article DE Depression; Psychosocial; Health; HIV-positive; Africa ID SUB-SAHARAN AFRICA; SELF-REPORTED ADHERENCE; CD4 CELL COUNT; SOUTH-AFRICA; MENTAL-HEALTH; ALCOHOL-USE; ANTIRETROVIRAL THERAPY; INFECTED INDIVIDUALS; DISEASE PROGRESSION; PARTNER VIOLENCE AB In sub-Saharan Africa, the prevalence of depressive symptoms among people living with HIV (PLHIV) is considerably greater than that among members of the general population. It is particularly important to treat depressive symptoms among PLHIV because they have been associated with poorer HIV care-related outcomes. This study describes overall psychosocial functioning and factors associated with depressive symptoms among PLHIV attending HIV care and treatment clinics in Kenya, Namibia, and Tanzania. Eighteen HIV care and treatment clinics (six per country) enrolled approximately 200 HIV-positive patients (for a total of 3,538 participants) and collected data on patients' physical and mental well-being, medical/health status, and psychosocial functioning. Although the majority of participants did not report clinically significant depressive symptoms (72 %), 28 % reported mild to severe depressive symptoms, with 12 % reporting severe depressive symptoms. Regression models indicated that greater levels of depressive symptoms were associated with: (1) being female, (2) younger age, (3) not being completely adherent to HIV medications, (4) likely dependence on alcohol, (5) disclosure to three or more people (versus one person), (6) experiences of recent violence, (7) less social support, and (8) poorer physical functioning. Participants from Kenya and Namibia reported greater depressive symptoms than those from Tanzania. Approximately 28 % of PLHIV reported clinically significant depressive symptoms. The scale-up of care and treatment services in sub-Saharan Africa provides an opportunity to address psychosocial and mental health needs for PLHIV as part of comprehensive care. C1 [Seth, Puja; Kidder, Daniel; Pals, Sherri; Bachanas, Pamela] US Ctr Dis Control & Prevent, Div Global HIV AIDS, Ctr Global Hlth, Atlanta, GA 30333 USA. [Parent, Julie; Katuta, Frieda] Minist Hlth & Social Serv, Windhoek, Namibia. [Mbatia, Redempta] Tanzania Hlth Promot Support, Dar Es Salaam, Tanzania. [Chesang, Kipruto] US Ctr Dis Control & Prevent, Nairobi, Kenya. [Mbilinyi, Deogratius] US Ctr Dis Control & Prevent, Dar Es Salaam, Tanzania. [Koech, Emily] ICAP, Nairobi, Kenya. [Nkingwa, Mathias] Minist Hlth & Social Welf, Dar Es Salaam, Tanzania. [Ng'ang'a, Anne] Minist Hlth & Social Welf, Nairobi, Kenya. RP Seth, P (reprint author), US Ctr Dis Control & Prevent, Div Global HIV AIDS, Ctr Global Hlth, 1600 Clifton Rd,MS E04, Atlanta, GA 30333 USA. EM pseth@cdc.gov FU Intramural CDC HHS [CC999999]; PEPFAR NR 62 TC 5 Z9 5 U1 1 U2 7 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1389-4986 EI 1573-6695 J9 PREV SCI JI Prev. Sci. PD JUN PY 2014 VL 15 IS 3 BP 318 EP 328 DI 10.1007/s11121-013-0420-8 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AH7AB UT WOS:000336283200007 PM 23868419 ER PT J AU Knight, KR Das, M DeMicco, E Raiford, JL Matheson, T Shook, A Antunez, E Santos, GM Dadasovich, R Dilley, JW Colfax, GN Herbst, JH AF Knight, Kelly R. Das, Moupali DeMicco, Erin Raiford, Jerris L. Matheson, Tim Shook, Alic Antunez, Erin Santos, Glenn-Milo Dadasovich, Rand Dilley, James W. Colfax, Grant N. Herbst, Jeffrey H. TI A Roadmap for Adapting an Evidence-Based HIV Prevention Intervention: Personal Cognitive Counseling (PCC) for Episodic Substance-Using Men Who Have Sex with Men SO PREVENTION SCIENCE LA English DT Article DE HIV prevention; Evidence-based intervention; Adaptation; Episodic substance use; MSM ID UNPROTECTED ANAL INTERCOURSE; GAY MEN; BISEXUAL MEN; RISK BEHAVIORS; METHAMPHETAMINE USE; CONTROLLED-TRIAL; SELF-EFFICACY; AIDS; TRANSMISSION; DEPENDENCE AB Episodic (less than weekly) drug use and binge drinking increase HIV-related sexual risk behaviors among men who have sex with men (MSM), yet no evidence-based interventions exist for these men. We describe an adaptation process of the Personalized Cognitive Counseling (PCC) intervention for utilization with high-risk, HIV-negative episodic, substance-using MSM. Participants (N = 59) were racially diverse, and reported unprotected anal intercourse and concurrent binge drinking (85 %), use of poppers (36 %), methamphetamine (20 %) and cocaine (12 %). Semi-structured interviews with 20 episodic, substance-using MSM elicited sexual narratives for engaging in unprotected anal intercourse while using alcohol or drugs. Emergent qualitative themes were translated into self-justifications and included in a revised PCC self-justification elicitation instrument (SJEI). The adapted SJEI was pretested with 19 episodic, substance-using MSM, and the final adapted PCC was pilot-tested for acceptability and feasibility with 20 episodic, substance-using MSM. This process can be used as a roadmap for adapting PCC for other high-risk populations of MSM. C1 [Knight, Kelly R.] Univ Calif San Francisco, Dept Anthropol Hist & Social Med, San Francisco, CA 94143 USA. [Das, Moupali; DeMicco, Erin; Matheson, Tim; Shook, Alic; Antunez, Erin; Santos, Glenn-Milo; Dadasovich, Rand; Colfax, Grant N.] San Francisco Dept Publ Hlth, HIV Prevent Sect, Subst Use Res Unit, San Francisco, CA USA. [Dilley, James W.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA. [Dilley, James W.] San Francisco Gen Hosp, San Francisco, CA 94110 USA. [Raiford, Jerris L.; Herbst, Jeffrey H.] CDC, Prevent Res Branch, Div HIV AIDS Prevent, NCHHSTP, Atlanta, GA 30333 USA. RP Knight, KR (reprint author), Univ Calif San Francisco, Dept Anthropol Hist & Social Med, 3333 Calif St,Suite 485, San Francisco, CA 94143 USA. EM kelly.knight@ucsf.edu FU Intramural CDC HHS [CC999999]; NCHHSTP CDC HHS [UR6PS000684, UR6 PS000684] NR 55 TC 8 Z9 8 U1 3 U2 9 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1389-4986 EI 1573-6695 J9 PREV SCI JI Prev. Sci. PD JUN PY 2014 VL 15 IS 3 BP 364 EP 375 DI 10.1007/s11121-013-0364-z PG 12 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AH7AB UT WOS:000336283200011 PM 23412947 ER PT J AU Pearce, BD Kruszon-Moran, D Jones, JL AF Pearce, Brad D. Kruszon-Moran, Deanna Jones, Jeffrey L. TI The association of Toxoplasma gondii infection with neurocognitive deficits in a population-based analysis SO SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY LA English DT Article DE Infection; Cognition; Neuroimmunology; Population-based study ID NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; NEUROBEHAVIORAL TEST-PERFORMANCE; RISK-FACTORS; COGNITIVE FUNCTION; BEHAVIORAL-CHANGES; TRAFFIC ACCIDENTS; KYNURENIC ACID; UNITED-STATES; NHANES-III AB To examine the relationship between infection with Toxoplasma gondii (toxo) and cognition. Multivariate logistic regression was used to test the association of toxo seropositivity with indices of cognitive function among over 4,200 adults in the third National Health and Nutrition Examination Survey. Toxo-seropositive participants were more likely than seronegative participants to score in the worst quartile of the simple reaction time test (OR 1.3, 95 % CI 1.0, 1.6), symbol-digit substitution test (SDST, OR 1.5, 95 % CI 1.2, 1.9) and the serial-digit learning test (trials to criterion) (SDLTNT, OR 1.4, 95 % CI 1.1, 1.8) in models adjusted for age, race/ethnicity, gender and foreign birth. After further adjustment for all cofactors, the association between toxo seropositivity and these outcomes was no longer significant. However, seropositivity was associated with worse scores on the SDST (OR 2.9, 95 % CI 1.8, 4.8) among those in the lowest income category and the SDLTNT (OR 1.5, 95 % CI 1.1, 2.5) among those foreign born. Toxo seropositivity may be associated with poor cognitive test scores in certain subgroups; however, causation cannot be established in this cross-sectional study. C1 [Pearce, Brad D.] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Kruszon-Moran, Deanna] Ctr Dis Control & Prevent, Div Hlth & Nutr Examinat Stat, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Jones, Jeffrey L.] Ctr Dis Control & Prevent, Parasit Dis Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30333 USA. RP Pearce, BD (reprint author), Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, 1518-002-3BB, Atlanta, GA 30322 USA. EM bpearce@emory.edu FU National Institutes of Health (National Institute of Mental Health, National Institute of Child Health and Human Development); March of Dimes; NARSAD; Emory Neuroscience Initiative FX We thank Dr. Nancy Bliwise for helpful input on the early phase of this project and Dr. Myfawny Hopkins for her critical reading of the manuscript. Dr. Pearce reports grant support from the National Institutes of Health (National Institute of Mental Health, National Institute of Child Health and Human Development), The March of Dimes, NARSAD, and the Emory Neuroscience Initiative. NR 39 TC 8 Z9 8 U1 3 U2 12 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0933-7954 EI 1433-9285 J9 SOC PSYCH PSYCH EPID JI Soc. Psychiatry Psychiatr. Epidemiol. PD JUN PY 2014 VL 49 IS 6 BP 1001 EP 1010 DI 10.1007/s00127-014-0820-5 PG 10 WC Psychiatry SC Psychiatry GA AH7BR UT WOS:000336287900016 PM 24477344 ER PT J AU Kosa, KM Cates, SC Hall, AJ Brophy, JE Frasier, A AF Kosa, Katherine M. Cates, Sheryl C. Hall, Aron J. Brophy, Jenna E. Frasier, Angela TI Knowledge of norovirus prevention and control among infection preventionists SO AMERICAN JOURNAL OF INFECTION CONTROL LA English DT Article DE Survey; Core competency ID UNITED-STATES; DISEASE; GASTROENTERITIS; EFFICACY AB A Web-based survey was administered to infection preventionists (IPs) (N = 941) to characterize awareness and knowledge of norovirus (NoV). Only 44% of respondents correctly identified NoV as one of the 3 most common foodborne pathogens in the United States, and 5% correctly identified the 3 most common settings for NoV outbreaks. Several gaps in IPs' knowledge of NoV were identified; specifically, IPs could benefit from learning more about the natural history of NoV, modes of transmission, and cleaning and disinfection processes. Copyright (C) 2014 by the Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved. C1 [Kosa, Katherine M.; Cates, Sheryl C.; Brophy, Jenna E.] RTI Int, Food & Nutr Policy Res, Res Triangle Pk, NC 27709 USA. [Hall, Aron J.] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA. [Frasier, Angela] Clemson Univ, Dept Food Nutr & Packaging Sci, Clemson, SC USA. RP Kosa, KM (reprint author), RTI Int, Food & Nutr Policy Res, 3040 Cornwallis Rd,POB 12194, Res Triangle Pk, NC 27709 USA. EM kkosa@rti.org FU Agriculture and Food Research Initiative (AFRI) Competitive Grant from the US Department of Agriculture, National Institute of Food and Agriculture [2011-68003-30395]; Association for Professionals in Infection Control and Epidemiology Research Program FX Supported by the Agriculture and Food Research Initiative (AFRI) Competitive Grant No. 2011-68003-30395 from the US Department of Agriculture, National Institute of Food and Agriculture, and by the Association for Professionals in Infection Control and Epidemiology Research Program. NR 14 TC 2 Z9 2 U1 1 U2 7 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-6553 EI 1527-3296 J9 AM J INFECT CONTROL JI Am. J. Infect. Control PD JUN PY 2014 VL 42 IS 6 BP 676 EP 678 DI 10.1016/j.ajic.2014.02.004 PG 3 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AH1UB UT WOS:000335905500022 PM 24837119 ER PT J AU Ruch-Ross, HS Zapata, LB Williams, JL Ruhl, C AF Ruch-Ross, Holly S. Zapata, Lauren B. Williams, Jennifer L. Ruhl, Catherine TI General influenza infection control policies and practices during the 2009 H1N1 influenza pandemic: A survey of women's health, obstetric, and neonatal nurses SO AMERICAN JOURNAL OF INFECTION CONTROL LA English DT Article DE Hospital policy and practice; H1N1 pandemic; Labor and delivery; Hospital nursery; CDC guidance ID APRIL-MAY 2009; CARE WORKERS; UNITED-STATES; PREGNANT-WOMEN; SOUTHERN CALIFORNIA; VIRUS-INFECTIONS; VACCINATION; PERSONNEL; ILLNESS; TRANSMISSION AB Background: An evaluation of infection control practices was conducted following the release of the Centers for Disease Control and Prevention (CDC) guidance regarding the care of pregnant women during the 2009 H1N1 influenza pandemic. This paper describes 9 general hospital practices. Methods: A questionnaire was distributed electronically to 12,612 members of the Association of Women's Health, Obstetric, and Neonatal Nurses (AWHONN). Respondents (N = 2,304) who reported working in obstetric or neonatal settings during the pandemic completed the questionnaire. Results: Most (73%) respondents considered the Centers for Disease Control and Prevention's guidance very useful. Significantly more reported a written hospital policy for each practice during versus before the pandemic. Six of the 9 practices were implemented most of the time by at least 70% of respondents; the practices least often implemented were mandatory vaccination of health care personnel involved (52%) and not involved (34%) in direct patient care and offering vaccination to close contacts of newborns prior to discharge (22%). The most consistent factor associated with implementation was the presence of a written policy supporting the practice at the respondent's hospital. Conclusion: We offer a descriptive account of general hospital infection control policies and practices during the 2009 H1N1 pandemic. Factors associated with reported implementation may be useful to inform planning to protect women and children for future public health emergencies. Copyright (C) 2014 by the Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved. C1 [Zapata, Lauren B.; Williams, Jennifer L.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Ruhl, Catherine] Assoc Womens Hlth Obstetr & Neonatal Nurses, Washington, DC USA. RP Ruch-Ross, HS (reprint author), 9345 Avers Ave, Evanston, IL 60203 USA. EM hruchross@aol.com FU Intramural CDC HHS [CC999999] NR 34 TC 0 Z9 0 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-6553 EI 1527-3296 J9 AM J INFECT CONTROL JI Am. J. Infect. Control PD JUN PY 2014 VL 42 IS 6 BP E65 EP E70 DI 10.1016/j.ajic.2014.02.022 PG 6 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AH1UB UT WOS:000335905500001 PM 24837128 ER PT J AU Botelho, JC Ribera, A Cooper, HC Vesper, HW AF Botelho, Julianne Cook Ribera, Ashley Cooper, Hans C. Vesper, Hubert W. TI CDC Standardization Programs - Testosterone, Estradiol, and Vitamin D SO ENDOCRINE REVIEWS LA English DT Meeting Abstract C1 [Botelho, Julianne Cook; Ribera, Ashley; Cooper, Hans C.; Vesper, Hubert W.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0163-769X EI 1945-7189 J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2014 VL 35 IS 3 SU S MA SAT-0265 PG 3 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA V45GM UT WOS:000209805106006 ER PT J AU Boehme, AK McGwin, G Andes, DR Lyon, GM Chiller, T Pappas, PG Baddley, JW AF Boehme, Amelia K. McGwin, Gerald Andes, David R. Lyon, G. Marshall Chiller, Tom Pappas, Peter G. Baddley, John W. TI RACE AND INVASIVE FUNGAL INFECTION IN SOLID ORGAN TRANSPLANT RECIPIENTS SO ETHNICITY & DISEASE LA English DT Article DE Invasive Fungal Infection; Solid Organ Transplant; Aspergillosis; Candidiasis; Cryptococcosis ID SURVEILLANCE NETWORK TRANSNET; LIVER-TRANSPLANTATION; ETHNIC DISPARITIES; RISK-FACTORS; COCCIDIOIDOMYCOSIS; SURVIVAL; ACCESS AB Health disparities in access to solid organ transplantation (SOT) and graft survival are well recognized, but there are limited data on the relationship of race to risk of invasive fungal infection (IFI) among SOT recipients. We conducted a case-control study using data from the Transplant-Associated Infection Surveillance Network (TRANSNET) to investigate race and IFI. Cases (n=1,214) and controls (n=16,550) were compared on demographic variables using chi-square, and the relationship between race and IFI was assesses with unconditional logistic regression. Compared to White transplant patients, Blacks had similar odds of developing IFI (OR=.97, 95% CI 0.82-1.15, P=.7125), while participants who identified as other ethnicity were less likely to develop IFI (OR=.56, 95% CI .41-.75, P<.001). Blacks, when compared to White patients, were at increased odds of developing cryptococcal infection (OR 2.19, 95%CI 1.35-3.54, P=.002). Despite pharmacogenetic differences, Black transplant recipients were not more likely overall to develop IFI compared to White transplant recipients. C1 [Boehme, Amelia K.] Univ Alabama Birmingham, Sch Publ Hlth, Birmingham, AL 35294 USA. [Andes, David R.] Univ Wisconsin, Madison, WI 53706 USA. [Lyon, G. Marshall] Emory Univ, Sch Med, Atlanta, GA 30322 USA. [Chiller, Tom] Ctr Dis Control, Atlanta, GA 30333 USA. [Pappas, Peter G.; Baddley, John W.] Univ Alabama Birmingham, Sch Med, Birmingham, AL 35294 USA. [Baddley, John W.] Birmingham VA Med Ctr, Birmingham, AL 35233 USA. RP Baddley, JW (reprint author), Univ Alabama Birmingham, Div Infect Dis, 1900 Univ Blvd,THT 229, Birmingham, AL 35294 USA. EM jbaddley@uab.edu FU CDC; Astellas; Pfizer; Merck; Schering Plough FX TRANSNET was sponsored by the CDC, Astellas, Pfizer, Merck, and Schering Plough. We would like to thank the following TRANSNET Investigators: Barbara Alexander, MD, Duke University; Elias Anaissie, MD, University of Arkansas; Michael Boeckh, MD, Fred Hutchinson Cancer Research Center; Janice Brown, MD, Stanford University; Lisa Brumble, MD, Mayo Clinic-Jacksonville; Alison Freifeld, MD, University of Nebraska; Yoav Golan, MD, and Susan Hadley, MD, Tufts University; Loreen Herwaldt, MD, University of Iowa; James Ito, MD, City of Hope National Medical Center; Carol Kauffman, MD, University of Michigan; Katherine Knapp, MD, St. Jude Children's Hospital; Dimitrios Kontoyiannis, MD, MD Anderson Cancer Center; Kieren Marr, MD and Trish Perl, MD, Johns Hopkins Medical Institute; Vicki Morrison, MD, University of Minnesota; Genovefa Papanicolaou, MD, Memorial Sloan-Kettering Cancer Center; Tom Patterson, MD, University of Texas HSC-San Antonio; Mindy Schuster, MD, University of Pennsylvania; Randall Walker, MD, Mayo Clinic-Rochester; Tom Walsh, MD, Weill Cornell Medical College; John Wingard, MD, University of Florida. NR 17 TC 1 Z9 1 U1 0 U2 0 PU INT SOC HYPERTENSION BLACKS-ISHIB PI ATLANTA PA 100 AUBURN AVE NE STE 401, ATLANTA, GA 30303-2527 USA SN 1049-510X EI 1945-0826 J9 ETHNIC DIS JI Ethn. Dis. PD SUM PY 2014 VL 24 IS 3 BP 382 EP 385 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CU7KT UT WOS:000363717300018 PM 25065083 ER PT J AU Moreno-Madrinan, MJ Crosson, WL Eisen, L Estes, SM Estes, MG Hayden, M Hemmings, SN Irwin, DE Lozano-Fuentes, S Monaghan, AJ Quattrochi, D Welsh-Rodriguez, CM Zielinski-Gutierrez, E AF Moreno-Madrinan, Max J. Crosson, William L. Eisen, Lars Estes, Sue M. Estes, Maurice G., Jr. Hayden, Mary Hemmings, Sarah N. Irwin, Dan E. Lozano-Fuentes, Saul Monaghan, Andrew J. Quattrochi, Dale Welsh-Rodriguez, Carlos M. Zielinski-Gutierrez, Emily TI Correlating Remote Sensing Data with the Abundance of Pupae of the Dengue Virus Mosquito Vector, Aedes aegypti, in Central Mexico SO ISPRS INTERNATIONAL JOURNAL OF GEO-INFORMATION LA English DT Article DE MODIS; TRMM; DEM; Aqua; remote sensing; elevation; mosquito; rainfall; temperature ID LIFE TABLE MODEL; RIO-DE-JANEIRO; CLIMATE-CHANGE; INFECTIOUS-DISEASES; HELMINTH INFECTIONS; POTENTIAL INFLUENCE; BORNE DISEASES; UNITED-STATES; HUMAN HEALTH; VARIABILITY AB Using a geographic transect in Central Mexico, with an elevation/climate gradient, but uniformity in socio-economic conditions among study sites, this study evaluates the applicability of three widely-used remote sensing (RS) products to link weather conditions with the local abundance of the dengue virus mosquito vector, Aedes aegypti (Ae. aegypti). Field-derived entomological measures included estimates for the percentage of premises with the presence of Ae. aegypti pupae and the abundance of Ae. aegypti pupae per premises. Data on mosquito abundance from field surveys were matched with RS data and analyzed for correlation. Daily daytime and nighttime land surface temperature (LST) values were obtained from Moderate Resolution Imaging Spectroradiometer (MODIS)/Aqua cloud-free images within the four weeks preceding the field survey. Tropical Rainfall Measuring Mission (TRMM)-estimated rainfall accumulation was calculated for the four weeks preceding the field survey. Elevation was estimated through a digital elevation model (DEM). Strong correlations were found between mosquito abundance and RS-derived night LST, elevation and rainfall along the elevation/climate gradient. These findings show that RS data can be used to predict Ae. aegypti abundance, but further studies are needed to define the climatic and socio-economic conditions under which the correlations observed herein can be assumed to apply. C1 [Moreno-Madrinan, Max J.] Indiana Univ, IUPUI, Fairbanks Sch Publ Hlth, Dept Environm Hlth, Indianapolis, IN 46202 USA. [Crosson, William L.; Hemmings, Sarah N.] USRA, Inst Sci & Technol, Huntsville, AL 35805 USA. [Eisen, Lars; Lozano-Fuentes, Saul] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA. [Estes, Sue M.; Estes, Maurice G., Jr.] Univ Alabama, Earth & Syst Sci Ctr, Huntsville, AL 35805 USA. [Hayden, Mary; Monaghan, Andrew J.] Natl Ctr Atmospher Res, Res Applicat Lab, Boulder, CO 80307 USA. [Hemmings, Sarah N.] NASA Headquarters, Div Earth Sci, Appl Sci Program, Washington, DC 20024 USA. [Irwin, Dan E.; Quattrochi, Dale] NASA Marshall Space Flight Ctr, Earth Sci, Huntsville, AL 35811 USA. [Welsh-Rodriguez, Carlos M.] Veracruz Univ, Ctr Earth Sci, Xalapa 91090, Veracruz, Mexico. [Zielinski-Gutierrez, Emily] Ctr Dis Control & Prevent, Div Vector Borne Dis, Natl Ctr Emerging & Zoonot Infect Dis, Ft Collins, CO 80521 USA. RP Moreno-Madrinan, MJ (reprint author), Indiana Univ, IUPUI, Fairbanks Sch Publ Hlth, Dept Environm Hlth, Indianapolis, IN 46202 USA. EM mmorenom@iu.edu; bill.crosson@nasa.gov; lars.eisen@colostate.edu; sue.m.estes@nasa.gov; maury.estes@nsstc.uah.edu; monaghan@ucar.edu; sarah.n.hemmings@nasa.gov; daniel.irwin@nasa.gov; saul.lozano-fuentes@colostate.edu; mhayden@ucar.edu; dale.quattrochi@nasa.gov; cwelsh@uv.mx; Ebz0@cdc.gov OI Monaghan, Andrew/0000-0002-8170-2359 FU National Aeronautic and Space Administration (NASA); National Science Foundation (NSF); NASA through ROSES: Earth Science Applications Feasibility Studies: Public Health [A.31]; NASA [10-PHFEAS10-0010]; NSF [GEO-1010204]; SERVIR FX This study was funded by grants from the National Aeronautic and Space Administration (NASA) and the National Science Foundation (NSF). The NASA funds were granted through ROSES-2010: Earth Science Applications Feasibility Studies: Public Health (A.31); and to the Applied Earth Sciences group at the Marshall Space Flight Center (MSFC) (10-PHFEAS10-0010). The NSF funds were granted to the University Corporation for Atmospheric Research (GEO-1010204). The National Center for Atmospheric Research is partially funded by NSF. A partial contribution was provided by an appointment to the NASA Postdoctoral Program at the Marshall Space Flight Center/National Space Science and Technology Center/NASA Global Hydrology and Climate Center in Huntsville, AL, USA; administered by Oak Ridge Associated Universities through a contract with NASA. We express our appreciation to Douglas Rickman and Mohammad Z. Al-Hamdan for their guidance in the processing of remote sensing applications, as well as to SERVIR for providing logistics and support. We thank Gina Wade for helping with the proposal. We also thank Carolina Ochoa-Martinez and Berenice Tapia-Santos for running the field teams and to Kevin Kobylinski and Chris Uejio for helping out in the field. Lastly but not the least we thank the students from Veracruz University who helped with the field work completing the survey and collecting the in situ data. NR 61 TC 1 Z9 2 U1 2 U2 11 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2220-9964 J9 ISPRS INT J GEO-INF JI ISPRS Int. Geo-Inf. PD JUN PY 2014 VL 3 IS 2 BP 732 EP 749 DI 10.3390/ijgi3020732 PG 18 WC Geography, Physical; Remote Sensing SC Physical Geography; Remote Sensing GA CO1RO UT WOS:000358933100018 ER PT J AU Kershaw, KN Brenes, GA Charles, LE Coday, M Daviglus, ML Denburg, NL Kroenke, CH Safford, MM Savla, T Tindle, HA Tinker, LF Van Horn, L AF Kershaw, Kiarri N. Brenes, Gretchen A. Charles, Luenda E. Coday, Mace Daviglus, Martha L. Denburg, Natalie L. Kroenke, Candyce H. Safford, Monika M. Savla, Tina Tindle, Hilary A. Tinker, Lesley F. Van Horn, Linda TI Associations of Stressful Life Events and Social Strain With Incident Cardiovascular Disease in the Women's Health Initiative SO JOURNAL OF THE AMERICAN HEART ASSOCIATION LA English DT Article DE cardiovascular diseases; epidemiology; stress AB Background-Epidemiologic studies have yielded mixed findings on the association of psychosocial stressors with cardiovascular disease (CVD) risk. In this study, we examined associations of stressful life events (SLE) and social strain with incident coronary heart disease (CHD) and stroke (overall, and for hemorrhagic and ischemic strokes) independent of sociodemographic characteristics, and we evaluated whether these relationships were explained by traditional behavioral and biological risk factors. Methods and Results-Data from approximately 82 000 Women's Health Initiative Observational Study participants were used for the SLE and social strain analyses, respectively. Participants were followed for events for up to 18.0 years (median, 14.0). Separate Cox proportional hazards models were generated to estimate associations of each stress measure with incident CVD. After adjusting for sociodemographic characteristics and depressive symptoms, higher SLE and social strain were associated with higher incident CHD and stroke (each P trend <0.05). Hazard ratios and 95% confidence intervals were 1.12 (1.01, 1.25) for incident CHD and 1.14 (1.01, 1.28) for incident stroke among participants reporting high versus low SLE. Findings were similar for social strain. Associations were attenuated with further adjustment for mediating behavioral and biological risk factors. Findings were similar for associations of SLE with ischemic stroke and hemorrhagic stroke, but social strain was only associated with ischemic stroke. Conclusions-Higher SLE and social strain were associated with higher incident CVD independent of sociodemographic factors and depressive symptoms, but not behavioral and biological risk factors. C1 [Kershaw, Kiarri N.; Daviglus, Martha L.; Van Horn, Linda] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA. [Brenes, Gretchen A.] Wake Forest Sch Med, Dept Psychiat, Winston Salem, NC USA. [Charles, Luenda E.] Ctr Dis Control & Prevent, Natl Inst Occupat Safety & Hlth, Morgantown, WV USA. [Coday, Mace] Univ Tennessee, Ctr Hlth Sci, Dept Prevent Med, Memphis, TN 38163 USA. [Coday, Mace] Univ Tennessee, Ctr Hlth Sci, Dept Psychiat, Memphis, TN 38163 USA. [Daviglus, Martha L.] Univ Illinois, Dept Med, Chicago, IL USA. [Denburg, Natalie L.] Univ Iowa, Carver Coll Med, Dept Neurol, Des Moines, IA USA. [Kroenke, Candyce H.] Kaiser Permanente, Div Res, Oakland, CA USA. [Safford, Monika M.] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA. [Savla, Tina] Virginia Polytech Inst & State Univ, Dept Human Dev, Blacksburg, VA 24061 USA. [Tindle, Hilary A.] Univ Pittsburgh, Div Gen Internal Med, Pittsburgh, PA USA. [Tinker, Lesley F.] Fred Hutchinson Canc Res Ctr, Womens Hlth Initiat, Seattle, WA 98104 USA. RP Kershaw, KN (reprint author), Northwestern Univ, 680 N Lake Shore Dr,Suite 1400, Chicago, IL 60611 USA. EM k-kershaw@northwestern.edu RI Savla, Jyoti/J-7125-2015 OI Savla, Jyoti/0000-0001-7142-3770 FU NIH [N01-HC-95164]; National Heart, Lung and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services [HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, HHSN271201100004C] FX Dr Kershaw is funded by NIH grant N01-HC-95164. The WHI program is funded by the National Heart, Lung and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services through contracts HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, and HHSN271201100004C. NR 37 TC 8 Z9 9 U1 1 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2047-9980 J9 J AM HEART ASSOC JI J. Am. Heart Assoc. PD JUN PY 2014 VL 3 IS 3 AR e000687 DI 10.1161/JAHA.113.000687 PG 9 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA V41RD UT WOS:000209562400015 PM 24973226 ER PT J AU Sieber, WK Robinson, CF Birdsey, J Chen, GX Hitchcock, EM Lincoln, JE Nakata, A Sweeney, MH AF Sieber, W. Karl Robinson, Cynthia F. Birdsey, Jan Chen, Guang X. Hitchcock, Edward M. Lincoln, Jennifer E. Nakata, Akinori Sweeney, Marie H. TI Obesity and other risk factors: The National Survey of U.S. Long-Haul Truck Driver Health and Injury SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE LA English DT Article DE work practices; survey; risk factor; health; intervention; truck driver; surveillance ID PHYSICAL-ACTIVITY; INDUSTRY WORKERS; ACCIDENT RISK; UNITED-STATES; POPULATION; MORTALITY; DISEASES; ADULTS AB Background Drivers of heavy and tractor-trailer trucks accounted for 56% of all production and nonsupervisory employees in the truck transportation industry in 2011. There are limited data for illness and injury in long-haul truck drivers, which prompted a targeted national survey. Methods Interviewers collected data during 2010 from 1,670 long-haul truck drivers at 32 truck stops across the 48 contiguous United States that were used to compute prevalence estimates for self-reported health conditions and risk factors. Results Obesity (69% vs. 31%, P < 0.01) and current smoking (51% vs. 19%, P < 0.01) were twice as prevalent in long-haul truck drivers as in the 2010 U.S. adult working population. Sixty-one percent reported having two or more of the risk factors: hypertension, obesity, smoking, high cholesterol, no physical activity, 6 or fewer hours of sleep per 24-hr period. Conclusion Survey findings suggest a need for targeted interventions and continued surveillance for long-haul truck drivers. Am. J. Ind. Med. 57:615-626, 2014. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. C1 [Sieber, W. Karl; Robinson, Cynthia F.; Birdsey, Jan; Sweeney, Marie H.] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Chen, Guang X.; Lincoln, Jennifer E.] NIOSH, Div Safety Res, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. [Hitchcock, Edward M.] NIOSH, Div Appl Res & Technol, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Nakata, Akinori] Univ Occupat & Environm Hlth, Sch Hlth Sci, Fukuoka, Japan. RP Sieber, WK (reprint author), NIOSH, MSR 17,4476 Columbia Pkwy, Cincinnati, OH 45226 USA. EM wsieber@cdc.gov FU National Institute for Occupational Safety and Health; Federal Motor Carrier Safety Administration, U.S. Department of Transportation FX This work was supported by the National Institute for Occupational Safety and Health with partial funding from the Federal Motor Carrier Safety Administration, U.S. Department of Transportation. We wish to thank Albert Alvarez, Rebecca Brewster, Dale Belman, Michael Belzer, LaMont Byrd, Gerald Donaldson, Eric Garshick, Jim Helmkamp, Gerald Krueger, Scott Madar, Anne McCartt, Stephanie Pratt, Roger Rosa, Andy Schaudt, John Sestito, Aaron Sussell, Thomas Weakley, Martin Walker, Ann Williamson, and Eric Wood for their helpful comments and/or guidance in development of our survey and questionnaire. Teri Jacobs, Hovi Nguyen and Matthew Groenewold prepared maps. We in particular wish to thank the participating truck stops and drivers without whom this data collection would not have been possible. Westat Inc. provided data collection and statistical support. The findings and conclusions in this report are those of the author(s) and do not necessarily represent the views of the National Institute for Occupational Safety and Health. NR 65 TC 37 Z9 37 U1 0 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0271-3586 EI 1097-0274 J9 AM J IND MED JI Am. J. Ind. Med. PD JUN PY 2014 VL 57 IS 6 BP 615 EP 626 DI 10.1002/ajim.22293 PG 12 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AG4JU UT WOS:000335386600001 PM 24390804 ER PT J AU Steege, AL Boiano, JM Sweeney, MH AF Steege, Andrea L. Boiano, James M. Sweeney, Marie H. TI NIOSH Health and Safety Practices Survey of Healthcare Workers: Training and awareness of employer safety procedures SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE LA English DT Article DE self-report; healthcare worker; web-based survey; employer safe handling procedures; training; cognitive testing; professional practice organization ID PROTECTION; EXPOSURE AB Background The Health and Safety Practices Survey of Healthcare Workers describes current practices used to minimize chemical exposures and barriers to using recommended personal protective equipment for the following: antineoplastic drugs, anesthetic gases, high level disinfectants, surgical smoke, aerosolized medications (pentamidine, ribavirin, and antibiotics), and chemical sterilants. Methods Twenty-one healthcare professional practice organizations collaborated with NIOSH to develop and implement the web-based survey. Results Twelve thousand twenty-eight respondents included professional, technical, and support occupations which routinely come in contact with the targeted hazardous chemicals. Chemical-specific safe handling training was lowest for aerosolized antibiotics (52%, n = 316), and surgical smoke (57%, n = 4,747). Reported employer procedures for minimizing exposure was lowest for surgical smoke (32%, n = 4,746) and anesthetic gases (56%, n = 3,604). Conclusions Training and having procedures in place to minimize exposure to these chemicals is one indication of employer and worker safety awareness. Safe handling practices for use of these chemicals will be reported in subsequent papers. Am. J. Ind. Med. 57:640-652, 2014. (c) 2014 Wiley Periodicals, Inc. C1 [Steege, Andrea L.; Boiano, James M.; Sweeney, Marie H.] NIOSH, Surveillance Branch, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH 45226 USA. RP Steege, AL (reprint author), NIOSH, Div Surveillance Hazard Evaluat & Field Studies, 4676 Columbia Pkwy,MSR 18, Cincinnati, OH 45226 USA. EM asteege@cdc.gov RI Steege, Andrea/H-8900-2016 OI Steege, Andrea/0000-0001-5665-2559 FU National Institute for Occupational Safety and Health FX Contract grant sponsor: National Institute for Occupational Safety and Health. NR 26 TC 13 Z9 13 U1 0 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0271-3586 EI 1097-0274 J9 AM J IND MED JI Am. J. Ind. Med. PD JUN PY 2014 VL 57 IS 6 BP 640 EP 652 DI 10.1002/ajim.22305 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AG4JU UT WOS:000335386600003 PM 24549581 ER PT J AU Lara, J Purdy, MA Khudyakov, YE AF Lara, James Purdy, Michael A. Khudyakov, Yury E. TI Genetic host specificity of hepatitis E virus SO INFECTION GENETICS AND EVOLUTION LA English DT Article DE Hepatitis E virus; Prediction; HEV ORFs; Adaptation; Bayesian network; Coevolution ID RISK-FACTORS; C VIRUS; ZOONOTIC TRANSMISSION; DRUG-RESISTANCE; INFECTION; GENOTYPE; CHINA; EPIDEMIOLOGY; SEQUENCE; NETWORKS AB Hepatitis E virus (HEV) causes epidemic and sporadic cases of hepatitis worldwide. HEV genotypes 3 (HEV3) and 4 (HEV4) infect humans and animals, with swine being the primary reservoir. The relevance of HEV genetic diversity to host adaptation is poorly understood. We employed a Bayesian network (BN) analysis of HEV3 and HEV4 to detect epistatic connectivity among protein sites and its association with the host specificity in each genotype. The data imply coevolution among similar to 70% of polymorphic sites from all HEV proteins and association of numerous coevolving sites with adaptation to swine or humans. BN models for individual proteins and domains of the nonstructural polyprotein detected the host origin of HEV strains with accuracy of 74-93% and 63-87%, respectively. These findings, taken together with lack of phylogenetic association to host, suggest that the HEV host specificity is a heritable and convergent phenotypic trait achievable through variety of genetic pathways (abundance), and explain a broad host range for HEV3 and HEV4. Published by Elsevier B.V. C1 [Lara, James; Purdy, Michael A.; Khudyakov, Yury E.] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30333 USA. RP Lara, J (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30333 USA. EM jlara@cdc.gov NR 69 TC 5 Z9 5 U1 1 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1567-1348 EI 1567-7257 J9 INFECT GENET EVOL JI Infect. Genet. Evol. PD JUN PY 2014 VL 24 BP 127 EP 139 DI 10.1016/j.meegid.2014.03.011 PG 13 WC Infectious Diseases SC Infectious Diseases GA AG4GG UT WOS:000335376800015 PM 24667049 ER PT J AU Roebling, AD Johnson, D Blanton, JD Levin, M Slate, D Fenwick, G Rupprecht, CE AF Roebling, A. D. Johnson, D. Blanton, J. D. Levin, M. Slate, D. Fenwick, G. Rupprecht, C. E. TI Rabies Prevention and Management of Cats in the Context of Trap-Neuter-Vaccinate-Release Programmes SO ZOONOSES AND PUBLIC HEALTH LA English DT Article DE trap; release; vaccination; Cat; TNR ID FELINE IMMUNODEFICIENCY VIRUS; UNITED-STATES; FERAL CATS; TOXOPLASMA-GONDII; POSTEXPOSURE PROPHYLAXIS; LEUKEMIA-VIRUS; DOMESTIC CATS; RETURN; POPULATIONS; EPIDEMIOLOGY AB Domestic cats are an important part of many Americans' lives, but effective control of the 60-100 million feral cats living throughout the country remains problematic. Although trap-neuter-vaccinate-return (TNVR) programmes are growing in popularity as alternatives to euthanizing feral cats, their ability to adequately address disease threats and population growth within managed cat colonies is dubious. Rabies transmission via feral cats is a particular concern as demonstrated by the significant proportion of rabies post-exposure prophylaxis associated with exposures involving cats. Moreover, TNVR has not been shown to reliably reduce feral cat colony populations because of low implementation rates, inconsistent maintenance and immigration of unsterilized cats into colonies. For these reasons, TNVR programmes are not effective methods for reducing public health concerns or for controlling feral cat populations. Instead, responsible pet ownership, universal rabies vaccination of pets and removal of strays remain integral components to control rabies and other diseases. C1 [Roebling, A. D.; Johnson, D.; Blanton, J. D.; Levin, M.; Rupprecht, C. E.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Slate, D.] US Anim & Plant Hlth Inspect Serv, USDA, Wildlife Serv, Manchester, NH USA. [Fenwick, G.] Amer Bird Conservancy, The Plains, VA USA. RP Blanton, JD (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,MS G33, Atlanta, GA 30333 USA. EM Asi5@cdc.gov FU Intramural CDC HHS [CC999999] NR 41 TC 2 Z9 2 U1 3 U2 34 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1863-1959 EI 1863-2378 J9 ZOONOSES PUBLIC HLTH JI Zoonoses Public Health PD JUN PY 2014 VL 61 IS 4 BP 290 EP 296 DI 10.1111/zph.12070 PG 7 WC Public, Environmental & Occupational Health; Infectious Diseases; Veterinary Sciences SC Public, Environmental & Occupational Health; Infectious Diseases; Veterinary Sciences GA AF4JP UT WOS:000334678400008 PM 23859607 ER PT J AU Ayinmode, AB Zhang, H Dada-Adegbola, HO Xiao, L AF Ayinmode, A. B. Zhang, H. Dada-Adegbola, H. O. Xiao, L. TI Cryptosporidium hominis Subtypes and Enterocytozoon bieneusi Genotypes in HIV-Infected Persons in Ibadan, Nigeria SO ZOONOSES AND PUBLIC HEALTH LA English DT Article DE microsporidiosis; cryptosporidiosis; diarrhoea; Enterocytozoon bieneusi; HIV; opportunistic infection; epidemiology; Cryptosporidium ID ACTIVE ANTIRETROVIRAL THERAPY; INTESTINAL MICROSPORIDIOSIS; PERU; HIV/AIDS; DIARRHEA; VIRUS; HAART; LIMA AB Cryptosporidium and Enterocytozoon are common opportunistic pathogens in HIV+ patients in developing countries, especially those do not have access to antiretroviral therapy. To determine the distribution of genotypes/subtypes of Cryptosporidium and Enterocytozoon bieneusi, faecal specimens were collected from 132 HIV+ persons attending a tertiary hospital in Ibadan, Nigeria. By polymerase chain reaction, eight and ten patients were identified as positive for Cryptosporidium spp. and E.bieneusi, respectively. Seven of the Cryptosporidium specimens were identified as C.hominis, while the remaining one as the new species C.viatorum recently identified in the United Kingdom. DNA sequencing of the 60-kDa glycoprotein gene showed that the C.hominis belonged to three common subtype families: Ia (in three patients), Ib (in one patient) and Ie (in one patient). In contrast, DNA sequencing of the E.bieneusi internal transcribed spacer products showed the occurrence of genotypes associated with both humans (Peru 8 in one patient, Nig2 in two patients and a new genotype in one patient) and animals (D in one patient and Type IV in five patients). Low CD4+ cell count was identified as a risk factor for both cryptosporidiosis and microsporidiosis. C1 [Ayinmode, A. B.] Univ Ibadan, Dept Vet Microbiol & Parasitol, Fac Vet Med, Ibadan, Nigeria. [Zhang, H.] Henan Ctr Dis Prevent & Control, Inst Parasite Dis Prevent & Control, Zhengzhou, Peoples R China. [Dada-Adegbola, H. O.] Univ Coll Hosp, Dept Med Microbiol & Parasitol, Ibadan, Nigeria. [Xiao, L.] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30329 USA. RP Xiao, L (reprint author), Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Mail Stop D66,1600 Clifton Rd, Atlanta, GA 30329 USA. EM lxiao@cdc.gov RI Xiao, Lihua/B-1704-2013 OI Xiao, Lihua/0000-0001-8532-2727 FU PEP-FAR Grant FX We thank Dele Ajayi and Awoyemi E. J. Awosanya for technical assistance. This work was supported in part by PEP-FAR 2010 Grant to the University of Ibadan. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 28 TC 7 Z9 7 U1 0 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1863-1959 EI 1863-2378 J9 ZOONOSES PUBLIC HLTH JI Zoonoses Public Health PD JUN PY 2014 VL 61 IS 4 BP 297 EP 303 DI 10.1111/zph.12072 PG 7 WC Public, Environmental & Occupational Health; Infectious Diseases; Veterinary Sciences SC Public, Environmental & Occupational Health; Infectious Diseases; Veterinary Sciences GA AF4JP UT WOS:000334678400009 PM 23870732 ER PT J AU Henning, T Butler, K Mitchell, J Ellis, S Deyounks, F Farshy, C Phillips, C Papp, J Patton, D Caldwell, H Sturdevant, G McNicholl, J Kersh, E AF Henning, Tara Butler, Katherine Mitchell, James Ellis, Shanon Deyounks, Frank Farshy, Carol Phillips, Christi Papp, John Patton, Dorothy Caldwell, Harlan Sturdevant, Gail McNicholl, Janet Kersh, Ellen TI Development of a rectal sexually transmitted infection - HIV coinfection model utilizing Chlamydia trachomatis and SHIVSF162p3 SO JOURNAL OF MEDICAL PRIMATOLOGY LA English DT Article DE men who have sex with men; STD ID HUMAN-IMMUNODEFICIENCY-VIRUS; NEISSERIA-GONORRHOEAE; NONHUMAN-PRIMATES; MACAQUE MODEL; GENITAL-TRACT; TRANSMISSION; SEX; MEN; TENOFOVIR; SYSTEM AB BackgroundRectal sexually transmitted infections (STIs) may increase HIV susceptibility in men who have sex with men (MSM), and Chlamydia trachomatis is prevalent among HIV-positive MSM. To study STIs and HIV infection in MSM, we first evaluated whether cynomolgus macaques can sustain both C.trachomatis and SHIVSF162p3 infections(.) MethodsFour SHIVSF162p3-positive male cynomolgus macaques were used (n=3 rectally inoculated with 10(6) IFU; n=1 control). Systemic and rectal SHIV RNA levels and cytokines were measured by real-time PCR and Luminex assays, respectively. ResultsMacaques were successfully Chlamydia infected. Rectal SHIV shedding (P=0.02 (2)) and levels of G-CSF, IL-1ra, IL-6, IL-8, IFN-, and TNF- (P0.01, Mann-Whitney) in rectal secretions increased following infection. ConclusionsThese pilot data successfully demonstrate rectal C.trachomatis-SHIV coinfection in cynomolgus macaques and suggest the feasibility of a rectal C.trachomatis model for SHIV susceptibility and biomedical prevention studies in the context of rectal STIs. C1 [Henning, Tara; Butler, Katherine; Mitchell, James; Ellis, Shanon; Deyounks, Frank; McNicholl, Janet; Kersh, Ellen] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. [Farshy, Carol; Phillips, Christi; Papp, John] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30333 USA. [Patton, Dorothy] Univ Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA. [Caldwell, Harlan; Sturdevant, Gail] NIAID, Intracellular Parasites Lab, Rocky Mt Labs, NIH, Hamilton, MT USA. RP Kersh, E (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, 1600 Clifton Rd NE,MS A-25, Atlanta, GA 30333 USA. EM ekersh@cdc.gov FU CDC [Y1-A1-0681-02]; NIH [Y1-A1-0681-02] FX The authors thank Dr. John Brooks and Dr. Pragna Patel for advisement on rectal pathogens. The authors thank Patty Guenthner for her assistance with macaques' SHIV infection data from the previous titration study. This work was funded by CDC and an interagency agreement (Y1-A1-0681-02) between CDC and NIH. NR 27 TC 3 Z9 3 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0047-2565 EI 1600-0684 J9 J MED PRIMATOL JI J. Med. Primatol. PD JUN PY 2014 VL 43 IS 3 BP 135 EP 143 DI 10.1111/jmp.12103 PG 9 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA AF2EF UT WOS:000334524700001 PM 24460742 ER PT J AU Haider, N Rahman, MS Khan, SU Mikolon, A Gurley, ES Osmani, MG Shanta, IS Paul, SK Macfarlane-Berry, L Islam, A Desmond, J Epstein, JH Daszak, P Azim, T Luby, SP Zeidner, N Rahman, MZ AF Haider, N. Rahman, M. S. Khan, S. U. Mikolon, A. Gurley, E. S. Osmani, M. G. Shanta, I. S. Paul, S. K. Macfarlane-Berry, L. Islam, A. Desmond, J. Epstein, J. H. Daszak, P. Azim, T. Luby, S. P. Zeidner, N. Rahman, M. Z. TI Identification and Epidemiology of a Rare HoBi-Like Pestivirus Strain in Bangladesh SO TRANSBOUNDARY AND EMERGING DISEASES LA English DT Article DE BVDV-3; HoBi-like pestivirus; Bangladesh; cattle ID VIRAL DIARRHEA VIRUS; INFECTION; SUBSTITUTIONS; CATTLE AB The genus pestivirus of the family flaviviridae consists of four recognized species: bovine viral diarrhoea virus 1 (BVDV-1), bovine viral diarrhoea virus 2 (BVDV-2), classical swine fever virus and border disease virus. A new putative pestivirus species tentatively named as either 'HoBi-like pestivirus' or BVDV-3 has recently been identified in Brazil, Italy and Thailand. Despite reports of serological evidence of BVDV in Bangladesh, the types of the virus circulating in cattle have not been identified. We conducted surveillance in cattle from May 2009 to August 2010 in three government veterinary hospitals to characterize BVDV in cattle of Bangladesh. We tested serum for BVDV using an antigen-capture ELISA. Of 638 cattle samples, 3% (16/638) tested positive for BVDV antigen. The ELISA-positive samples were selected for further molecular detection and characterization of BVDV. Molecular analysis of the partial 5 ' untranslated region (UTR) nucleotide sequences of BVDV-positive samples identified the rare HoBi-like pestivirus or BVDV-3 virus circulating in cattle of Bangladesh. The identification of this rare HoBi-like pestivirus or BVDV-3 strain in Bangladesh warrants further surveillance to evaluate its impact on livestock production. C1 [Haider, N.; Rahman, M. S.; Khan, S. U.; Gurley, E. S.; Shanta, I. S.; Paul, S. K.; Macfarlane-Berry, L.; Azim, T.; Luby, S. P.; Zeidner, N.; Rahman, M. Z.] Int Ctr Diarrheal Dis Res, Dhaka, Bangladesh. [Khan, S. U.] Univ Florida, Coll Publ Hlth & Hlth Profess, Gainesville, FL USA. [Mikolon, A.] USDA, Hawthorne, CA USA. [Osmani, M. G.] Minist Fisheries, Dept Livestock Serv, Dhaka, Bangladesh. [Osmani, M. G.] Minist Livestock, Dept Livestock Serv, Dhaka, Bangladesh. [Islam, A.; Desmond, J.; Epstein, J. H.; Daszak, P.] EcoHlth Alliance, New York, NY USA. [Luby, S. P.] Stanford Univ, Stanford, CA 94305 USA. [Zeidner, N.] US Ctr Dis Control & Prevent, Atlanta, GA USA. RP Rahman, MZ (reprint author), Icddr B, Ctr Communicable Dis, Virol Lab, 68 Shaheed Tajuddin Ahmed Sarani, Dhaka 1212, Bangladesh. EM mzrahman@icddrb.org RI Haider, Najmul/F-6083-2015; Gurley, Emily/B-7903-2010; OI Haider, Najmul/0000-0002-5980-3460; Gurley, Emily/0000-0002-8648-9403; Luby, Stephen/0000-0001-5385-899X FU Google; Rockefeller foundation through EcoHealth Alliance FX This research was funded by Google and the Rockefeller foundation through EcoHealth Alliance. icddr,b acknowledges with gratitude the commitment of Google and the Rockefeller foundation to its research efforts. We acknowledge the Department of Livestock Services (DLS) of Bangladesh and the veterinarians Dr. Asma-Al-Hoseneara and Dr. Rashidul Hoque and Dr. Shama Ranjan Barua from DLS, Dr. Abdul Mannan and Dr. Shahneaz Ali Khan, from Chittagong Veterinary and Animal Sciences University, and Tahmina Sultana from icddr, b who were involved with this project. We are grateful to Ms. Diana DiazGranados, icddr, b, for her constructive support in editing this manuscript. NR 25 TC 12 Z9 15 U1 0 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1865-1674 EI 1865-1682 J9 TRANSBOUND EMERG DIS JI Transbound. Emerg. Dis. PD JUN PY 2014 VL 61 IS 3 BP 193 EP 198 DI 10.1111/tbed.12218 PG 6 WC Infectious Diseases; Veterinary Sciences SC Infectious Diseases; Veterinary Sciences GA AE9BH UT WOS:000334298300001 PM 24650238 ER PT J AU Kostova, D Andes, L Erguder, T Yurekli, A Keskinkilic, B Polat, S Culha, G Kilinc, EA Tasti, E Ersahin, Y Ozmen, M San, R Ozcebe, H Bilir, N Asma, S AF Kostova, Deliana Andes, Linda Erguder, Toker Yurekli, Ayda Keskinkilic, Bekir Polat, Sertac Culha, Gonul Kilinc, Evin Aras Tasti, Enver Ersahin, Yilmaz Ozmen, Mehmet San, Ramazan Ozcebe, Hilal Bilir, Nazmi Asma, Samira TI Cigarette Prices and Smoking Prevalence After a Tobacco Tax Increase - Turkey, 2008 and 2012 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Kostova, Deliana; Andes, Linda; Asma, Samira] CDC, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Erguder, Toker; Yurekli, Ayda] WHO, CH-1211 Geneva, Switzerland. [Keskinkilic, Bekir; Polat, Sertac; Culha, Gonul; Kilinc, Evin Aras] Turkey Minist Hlth, Ankara, Turkey. [Keskinkilic, Bekir; Polat, Sertac; Culha, Gonul; Kilinc, Evin Aras] Turkey Minist Hlth, Ankara, Turkey. [Tasti, Enver; Ersahin, Yilmaz; Ozmen, Mehmet; San, Ramazan] Turkish Stat Inst, Ankara, Turkey. [Ozcebe, Hilal; Bilir, Nazmi] Hacettepe Univ, Inst Publ Hlth, Ankara, Turkey. RP Kostova, D (reprint author), CDC, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. EM kiv0@cdc.gov NR 7 TC 8 Z9 8 U1 0 U2 8 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAY 30 PY 2014 VL 63 IS 21 BP 457 EP 461 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AI5OD UT WOS:000336917400002 PM 24871250 ER PT J AU Ritchey, MD Wall, HK Gillespie, C George, MG Jamal, A AF Ritchey, Matthew D. Wall, Hilary K. Gillespie, Cathleen George, Mary G. Jamal, Ahmed TI Million Hearts: Prevalence of Leading Cardiovascular Disease Risk Factors - United States, 2005-2012 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID PROGRESS; GOAL C1 [Ritchey, Matthew D.; Wall, Hilary K.; Gillespie, Cathleen; George, Mary G.] CDC, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Jamal, Ahmed] CDC, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. RP Ritchey, MD (reprint author), CDC, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. EM mritchey@cdc.gov NR 10 TC 12 Z9 12 U1 0 U2 3 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAY 30 PY 2014 VL 63 IS 21 BP 462 EP 467 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AI5OD UT WOS:000336917400003 PM 24871251 ER PT J AU Moturi, EK Porter, KA Wassilak, SGF Tangermann, RH Diop, OM Burns, CC Jafari, H AF Moturi, Edna K. Porter, Kimberly A. Wassilak, Steven G. F. Tangermann, Rudolf H. Diop, Ousmane M. Burns, Cara C. Jafari, Hamid TI Progress Toward Polio Eradication - Worldwide, 2013-2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Moturi, Edna K.] CDC, Atlanta, GA 30333 USA. [Porter, Kimberly A.; Wassilak, Steven G. F.] CDC, Global Immunizat Div, Ctr Global Hlth, Atlanta, GA 30333 USA. [Tangermann, Rudolf H.; Diop, Ousmane M.; Jafari, Hamid] WHO, Polio Eradicat Dept, Geneva, Switzerland. [Burns, Cara C.] CDC, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Moturi, EK (reprint author), CDC, Atlanta, GA 30333 USA. EM emoturi@cdc.gov RI Moturi, Edna/P-2835-2015 OI Moturi, Edna/0000-0002-1694-1476 NR 9 TC 38 Z9 38 U1 1 U2 10 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAY 30 PY 2014 VL 63 IS 21 BP 468 EP 472 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AI5OD UT WOS:000336917400004 PM 24871252 ER PT J AU Naleway, AL Irving, SA Henninger, ML Li, DK Shifflett, P Ball, S Williams, JL Cragan, J Gee, J Thompson, MG AF Naleway, Allison L. Irving, Stephanie A. Henninger, Michelle L. Li, De-Kun Shifflett, Pat Ball, Sarah Williams, Jennifer L. Cragan, Janet Gee, Julianne Thompson, Mark G. CA Vaccine Safety Datalink Pregnancy TI Safety of influenza vaccination during pregnancy: A review of subsequent maternal obstetric events and findings from two recent cohort studies SO VACCINE LA English DT Review DE Pregnancy; Influenza vaccine; Safety; Obstetric outcomes ID GESTATIONAL DIABETES-MELLITUS; H1N1 INFLUENZA; WOMEN; OUTCOMES; CHORIOAMNIONITIS; HYPERTENSION; DELIVERY; RISKS AB Pregnant women and their infants are vulnerable to severe disease and secondary complications from influenza infection. For this reason, annual influenza vaccination is recommended for all pregnant women in the United States. Women frequently cite concerns about vaccine safety as a barrier to vaccination. This review describes the safety of inactivated influenza vaccination during pregnancy with a focus on maternal obstetric events, including hypertensive disorders, gestational diabetes, and chorioamnionitis. Included in the review are new findings from two studies which examined the safety of seasonal inactivated influenza vaccination during pregnancy. The first study enrolled 641 pregnant women during the 2010-2011 season and prospectively followed them until delivery or pregnancy termination. The second study enrolled 1616 pregnant women during the 2010-2011 influenza season, and followed the women and their infants for six months after delivery. No associations between inactivated influenza vaccination and gestational diabetes, gestational hypertension, preeclampsia/eclampsia, or chorioamnionitis were observed in either cohort. When considered as a whole, these studies should further reassure women and clinicians that influenza vaccination during pregnancy is safe for mothers. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Naleway, Allison L.; Irving, Stephanie A.; Henninger, Michelle L.] Kaiser Permanente Northwest, Ctr Hlth Res, Portland, OR 97227 USA. [Li, De-Kun] Kaiser Permanente No Calif, Div Res, Oakland, CA 94612 USA. [Shifflett, Pat; Ball, Sarah] Abt Associates Inc, Cambridge, MA 02138 USA. [Williams, Jennifer L.; Cragan, Janet; Gee, Julianne; Thompson, Mark G.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Naleway, AL (reprint author), Kaiser Permanente Northwest, Ctr Hlth Res, 3800 N Interstate Ave, Portland, OR 97227 USA. EM allison.naleway@kpchr.org; stephanie.irving@kpchr.org; michelle.henninger@kpchr.org; de-kun.li@kp.org; pat_shifflett@abtassoc.com; sarah_ball@abtassoc.com; znv8@cdc.gov; jdc9@cdc.gov; dzg2@cdc.gov; isq8@cdc.gov OI Naleway, Allison/0000-0001-5747-4643; Irving, Stephanie/0000-0001-7437-6797; Shay, David/0000-0001-9619-4820 FU Centers for Disease Control and Prevention through America's Health Insurance Plans [200-2010-F-33132, 200-2002-00732] FX This work was supported by the Centers for Disease Control and Prevention (contract 200-2010-F-33132 through Abt Associates and contract 200-2002-00732 through America's Health Insurance Plans). Conflict of interest: The findings and conclusions reported in this article are those of the authors and do not necessarily represent the views of CDC, Abt Associates, AHIP, or Kaiser Foundation Research Institute. Each author reviewed and approved the final version of the article. A.N. reports receiving research funding from GlaxoSmithKline for an unrelated study. None of the remaining authors report any conflicts of interest. NR 40 TC 16 Z9 16 U1 2 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD MAY 30 PY 2014 VL 32 IS 26 BP 3122 EP 3127 DI 10.1016/j.vaccine.2014.04.021 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AI4YL UT WOS:000336872500002 PM 24742490 ER PT J AU Gessner, BD Feikin, DR AF Gessner, Bradford D. Feikin, Daniel R. TI Vaccine preventable disease incidence as a complement to vaccine efficacy for setting vaccine policy SO VACCINE LA English DT Review DE Cholera; Epidemiology; Haemophilus influenzae type b; Hib; Immunization; Malaria; Rotavirus; RTS,S; Pneumococcus; Streptococcus pneumoniae; Vaccine; Vaccine efficacy; Vaccine effectiveness ID PLACEBO-CONTROLLED TRIAL; DEVELOPING-COUNTRIES; ROTAVIRUS VACCINE; CONJUGATE VACCINE; DOUBLE-BLIND; CHILDREN; POPULATION; PREVALENCE; PNEUMONIA; INFLUENZA AB Traditionally, vaccines have been evaluated in clinical trials that establish vaccine efficacy (VE) against etiology-confirmed disease outcomes, a measure important for licensure. Yet, VE does not reflect a vaccine's public health impact because it does not account for relative disease incidence. An additional measure that more directly establishes a vaccine's public health value is the vaccine preventable disease incidence (VPDI), which is the incidence of disease preventable by vaccine in a given context. We describe how VE and VPDI can vary, sometimes in inverse directions, across disease outcomes and vaccinated populations. We provide examples of how VPDI can be used to reveal the relative public health impact of vaccines in developing countries, which can be masked by focus on VE alone. We recommend that VPDI be incorporated along with VE into the analytic plans of vaccine trials, as well as decisions by funders, ministries of health, and regulatory authorities. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Gessner, Bradford D.] Agence Med Prevent, F-75015 Paris, France. [Feikin, Daniel R.] Johns Hopkins Sch Publ Hlth, Dept Int Hlth, Int Vaccine Access Ctr, Baltimore, MD USA. [Feikin, Daniel R.] Ctr Dis Control & Prevent, Div Preparedness & Emerging Infect, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. RP Gessner, BD (reprint author), Agence Med Prevent, 164 Rue Vaugirard, F-75015 Paris, France. EM bgessner@aamp.org; dfeikin@jhsph.edu FU Intramural CDC HHS [CC999999] NR 24 TC 10 Z9 10 U1 0 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD MAY 30 PY 2014 VL 32 IS 26 BP 3133 EP 3138 DI 10.1016/j.vaccine.2014.04.019 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AI4YL UT WOS:000336872500004 PM 24731817 ER PT J AU Lu, PJ O'Halloran, A Ding, HL Williams, WW Bridges, CB Kennedy, ED AF Lu, Peng-jun O'Halloran, Alissa Ding, Helen Williams, Walter W. Bridges, Carolyn B. Kennedy, Erin D. TI National and state-specific estimates of place of influenza vaccination among adult populations - United States, 2011-12 influenza season SO VACCINE LA English DT Article DE Influenza vaccination; Place of influenza vaccination; Medical setting; Nonmedical setting; Behavioral Risk Factor Surveillance System (BRFSS) ID IMMUNIZATION PRACTICES; PROJECT VIVA; COVERAGE; HEALTH AB Background: Annual influenza vaccination has been recommended for all persons >= 6 months since the 2010-11 season. New partnerships between public health agencies and medical and nonmedical vaccination providers have increased the number of vaccination providers and locations where vaccination services are delivered. Methods: Data from the 2011-12 Behavioral Risk Factor Surveillance System (BRFSS) were analyzed. Point estimates of place of vaccination and 95% confidence intervals were calculated. Multivariable logistic regression and predictive marginal modeling were conducted to identify factors associated with vaccination settings. Results: Among adults vaccinated during the 2011-12 influenza season, a doctor's office was the most common place (38.4%) for receipt of influenza vaccination, with stores (e.g., supermarkets or drug stores) (20.1%) the next common, and workplaces (17.6%) the third common. Overall, reported vaccination in nonmedical settings by state ranged from 32.2% in California to 60.4% in Nevada, with a median of 45.8%. Characteristics significantly associated with an increased likelihood of receipt of vaccination in nonmedical settings were higher education, not having certain identified high-risk conditions, not having had a routine checkup in the previous 12 months, and not having a primary doctor for health care. Being a member of a racial/ethnic minority group, unemployed or not in the work force were significantly associated with a decreased likelihood of receipt of vaccination in nonmedical settings. Conclusion: Doctor's offices were the most common medical setting for adult influenza vaccination; workplaces and stores were important nonmedical settings. Increasing access to vaccination services in medical and nonmedical settings should be considered as important strategies for improving vaccination coverage. These results also can help guide development of strategies for achieving Healthy People 2020 objectives for influenza vaccination of adult populations. Published by Elsevier Ltd. C1 [Lu, Peng-jun; O'Halloran, Alissa; Ding, Helen; Williams, Walter W.; Bridges, Carolyn B.; Kennedy, Erin D.] Ctr Dis Control & Prevent, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Lu, PJ (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd,Mail Stop A-19, Atlanta, GA 30333 USA. EM lhp8@cdc.gov NR 25 TC 14 Z9 16 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD MAY 30 PY 2014 VL 32 IS 26 BP 3198 EP 3204 DI 10.1016/j.vaccine.2014.04.003 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AI4YL UT WOS:000336872500013 PM 24731815 ER PT J AU Haberle, SG Bowman, DMJS Newnham, RM Johnston, FH Beggs, PJ Buters, J Campbell, B Erbas, B Godwin, I Green, BJ Huete, A Jaggard, AK Medek, D Murray, F Newbigin, E Thibaudon, M Vicendese, D Williamson, GJ Davies, JM AF Haberle, Simon G. Bowman, David M. J. S. Newnham, Rewi M. Johnston, Fay H. Beggs, Paul J. Buters, Jeroen Campbell, Bradley Erbas, Bircan Godwin, Ian Green, Brett J. Huete, Alfredo Jaggard, Alison K. Medek, Danielle Murray, Frank Newbigin, Ed Thibaudon, Michel Vicendese, Don Williamson, Grant J. Davies, Janet M. TI The Macroecology of Airborne Pollen in Australian and New Zealand Urban Areas SO PLOS ONE LA English DT Article ID ANTHROPOGENIC CLIMATE-CHANGE; BIRCH POLLEN; GRASS-POLLEN; SEASONAL DISTRIBUTION; EASTERN AUSTRALIA; NORTH-AMERICA; BETULA POLLEN; ATMOSPHERE; EUROPE; SOUTH AB The composition and relative abundance of airborne pollen in urban areas of Australia and New Zealand are strongly influenced by geographical location, climate and land use. There is mounting evidence that the diversity and quality of airborne pollen is substantially modified by climate change and land-use yet there are insufficient data to project the future nature of these changes. Our study highlights the need for long-term aerobiological monitoring in Australian and New Zealand urban areas in a systematic, standardised, and sustained way, and provides a framework for targeting the most clinically significant taxa in terms of abundance, allergenic effects and public health burden. C1 [Haberle, Simon G.] Australian Natl Univ, Coll Asia & Pacific, Dept Archaeol & Nat Hist, Canberra, ACT, Australia. [Bowman, David M. J. S.; Williamson, Grant J.] Univ Tasmania, Sch Plant Sci, Hobart, Tas, Australia. [Newnham, Rewi M.] Victoria Univ Wellington, Sch Geog Environm & Earth Sci, Wellington, New Zealand. [Johnston, Fay H.] Univ Tasmania, Menzies Res Inst Tasmania, Hobart, Tas, Australia. [Beggs, Paul J.; Jaggard, Alison K.] Macquarie Univ, Fac Sci, Dept Geog & Environm, Sydney, NSW 2109, Australia. [Buters, Jeroen] Tech Univ Munich, Ctr Allergy & Environm, D-80290 Munich, Germany. [Campbell, Bradley; Godwin, Ian] Univ Queensland, Sch Agr & Food Sci, St Lucia, Qld, Australia. [Erbas, Bircan; Vicendese, Don] La Trobe Univ, Sch Publ Hlth & Human Biosci, Bundoora, Vic, Australia. [Green, Brett J.] NIOSH, Allergy & Clin Immunol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV USA. [Huete, Alfredo] Univ Technol Sydney, Sydney, NSW 2007, Australia. [Medek, Danielle] Australian Natl Univ, Sch Med, Canberra, ACT, Australia. [Murray, Frank] Murdoch Univ, Sch Environm Sci, Murdoch, WA 6150, Australia. [Newbigin, Ed] Univ Melbourne, Sch Bot, Melbourne, Vic, Australia. [Thibaudon, Michel] European Aerobiol Soc, Reseau Natl Surveillance Aerobiol, Lyon, Rhone Alpes, France. [Davies, Janet M.] Univ Queensland, Sch Med, Lung & Allergy Res Ctr, Woolloongabba, Qld, Australia. [Davies, Janet M.] Univ Queensland, Translat Res Inst, Woolloongabba, Qld, Australia. RP Haberle, SG (reprint author), Australian Natl Univ, Coll Asia & Pacific, Dept Archaeol & Nat Hist, Canberra, ACT, Australia. EM simon.haberle@anu.edu.au RI Davies, Janet/C-7989-2009; Buters, Jeroen/G-5070-2011; Huete, Alfredo/C-1294-2008; Bowman, David/A-2930-2011; OI Huete, Alfredo/0000-0003-2809-2376; Bowman, David/0000-0001-8075-124X; Haberle, Simon/0000-0001-5802-6535; Newbigin, Ed/0000-0002-9644-302X FU Australian Centre for Ecological Analysis and Synthesis (ACEAS) FX Funding support for the Working Group came from the Australian Centre for Ecological Analysis and Synthesis (ACEAS). Terrestrial Ecosystem Research Network ( TERN). Merck Sharp and Dohme provided additional independent untied co-sponsorship for the Working Group. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 63 TC 10 Z9 10 U1 0 U2 17 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 29 PY 2014 VL 9 IS 5 AR e97925 DI 10.1371/journal.pone.0097925 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AI3UR UT WOS:000336790800015 PM 24874807 ER PT J AU Volkow, ND Frieden, TR Hyde, PS Cha, SS AF Volkow, Nora D. Frieden, Thomas R. Hyde, Pamela S. Cha, Stephen S. TI Medication-Assisted Therapies - Tackling the Opioid-Overdose Epidemic SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Editorial Material ID DEATHS C1 [Volkow, Nora D.] NIDA, NIH, Bethesda, MD 20892 USA. [Hyde, Pamela S.] Subst Abuse & Mental Hlth Serv Adm, Rockville, MD USA. [Cha, Stephen S.] Ctr Medicare Serv, Ctr Medicaid & CHIP Serv, Baltimore, MD USA. [Cha, Stephen S.] Ctr Medicaid Serv, Ctr Medicaid & CHIP Serv, Baltimore, MD USA. [Frieden, Thomas R.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Volkow, ND (reprint author), NIDA, NIH, Bethesda, MD 20892 USA. NR 5 TC 133 Z9 133 U1 3 U2 14 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD MAY 29 PY 2014 VL 370 IS 22 BP 2063 EP 2066 DI 10.1056/NEJMp1402780 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA AH9BM UT WOS:000336434000003 PM 24758595 ER PT J AU Ma, JB Cai, JZ Ma, JW Feng, YY Xiao, LH AF Ma, Jingbo Cai, Jinzhong Ma, Jiawen Feng, Yaoyu Xiao, Lihua TI Occurrence and molecular characterization of Cryptosporidium spp. in yaks (Bos grunniens) in China SO VETERINARY PARASITOLOGY LA English DT Article DE Cryptosporidium; Qinghai; Yaks; 18S rRNA gene; Nested PCR; Genotype ID COW-CALF OPERATIONS; DEER-LIKE GENOTYPE; DAIRY-CATTLE; BEEF-CALVES; PREVALENCE; TRANSMISSION; INFECTION; DIARRHEA; QINGHAI; HEALTH AB Compared with dairy and beef cattle, few data are available on the occurrence and distribution of Cryptosporidium species in yaks, which live in a very different habitat. In this study, 327 fecal specimens were collected from yaks in 4 counties in Qinghai Province of China and screened for Cryptosporidium by nested PCR analysis of the 18S rRNA gene. A total of 98 (30.0%) specimens were positive for Cryptosporidium. The occurrence of Cryptosporidium varied significantly among age groups; infection rates were 49.3% in weaned calves, 31.7% in yearlings, and 17.4% in adults. PCR products of all Cryptosporidium-positive specimens were successfully sequenced, with 56 specimens (57.1%) having C. bovis, 33 (33.7%) having C. ryanae, 2 (2.0%) having C. andersoni, 1 (1.0%) having C. ubiquitum, 1 (1.0%) having C xiaoi, 2 (2.0%) having a novel genotype, and 3 (3.1%) having mixed infections of C bovis and C ryanae. There were some age-related differences in the distribution of Cryptosporidium species in post-weaned yaks examined. To our knowledge, this is the first report of C. andersoni, C. ubiquitum, C xiaoi and a novel Cryptosporidium genotype in yaks. Published by Elsevier B.V. C1 [Ma, Jingbo; Ma, Jiawen; Feng, Yaoyu] E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Sch Resources & Environm Engn, Shanghai 200237, Peoples R China. [Cai, Jinzhong] Qinghai Acad Vet Med & Anim Sci, Xining 810016, Peoples R China. [Xiao, Lihua] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. RP Xiao, LH (reprint author), Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. EM yyfeng@ecust.edu.cn; lxiao@cdc.gov RI Xiao, Lihua/B-1704-2013; Feng, Yaoyu/B-3076-2014 OI Xiao, Lihua/0000-0001-8532-2727; FU National Natural Science Foundation of China [31110103901, 31229005]; National Special Fund for State Key Laboratory of Bioreactor Engineering [2060204]; Fundamental Research Funds for the Central Universities, China [WB1214073] FX This work was supported by National Natural Science Foundation of China (31110103901 and 31229005), National Special Fund for State Key Laboratory of Bioreactor Engineering (No. 2060204), and Fundamental Research Funds for the Central Universities, China (No. WB1214073). NR 43 TC 12 Z9 16 U1 1 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-4017 EI 1873-2550 J9 VET PARASITOL JI Vet. Parasitol. PD MAY 28 PY 2014 VL 202 IS 3-4 BP 113 EP 118 DI 10.1016/j.vetpar.2014.03.030 PG 6 WC Parasitology; Veterinary Sciences SC Parasitology; Veterinary Sciences GA AI4XT UT WOS:000336870600004 PM 24768316 ER PT J AU Auld, AF Ekra, KA Shiraishi, RW Tuho, MZ Kouakou, JS Mohamed, F Ettiegne-Traore, V Sabatier, J Essombo, J Adjorlolo-Johnson, G Marlink, R Ellerbrock, TV AF Auld, Andrew F. Ekra, Kunomboa A. Shiraishi, Ray W. Tuho, Moise Z. Kouakou, Joseph S. Mohamed, Fayama Ettiegne-Traore, Virginie Sabatier, Jennifer Essombo, Joseph Adjorlolo-Johnson, Georgette Marlink, Richard Ellerbrock, Tedd V. TI Temporal Trends in Treatment Outcomes for HIV-1 and HIV-2-Infected Adults Enrolled in Cote d'Ivoire's National Antiretroviral Therapy Program SO PLOS ONE LA English DT Article ID SUB-SAHARAN AFRICA; REVERSE-TRANSCRIPTASE INHIBITORS; PHYSICIAN-PATIENT RELATIONSHIPS; SCALE-UP; DRUG-RESISTANCE; INFECTED ADULTS; SOUTH-AFRICA; COTRIMOXAZOLE PROPHYLAXIS; MULTIPLE IMPUTATION; FOOD INSECURITY AB Background: In C (o) over cap te d'Ivoire during 2004-2007, numbers of ART enrollees increased from,5,000 to 36,943. Trends in nationally representative ART program outcomes have not yet been reported. Methodology/Principal Findings: We conducted a retrospective chart review to assess trends in patient characteristics and attrition [death or loss to follow-up (LTFU)] over time, among a nationally representative sample of 3,682 adults (>= 15 years) initiating ART during 2004-2007 at 34 health facilities. Among ART enrollees during 2004-2007, median age was 36, the proportion female was 67%, the proportion HIV-2-infected or dually HIV-1&2 reactive was 5%, and median baseline CD4(+) T-cell (CD4) count was 135 cells/mu L. Comparing cohorts initiating ART in 2004 with cohorts initiating ART in 2007, median baseline weight declined from 55 kg to 52 kg (p = 0.008) and the proportion weighing <45 kg increased from 17% to 22% (p = 0.014). During 2004-2007, pharmacy-based estimates of the percentage of new ART enrollees >= 95% adherent to ART declined from 74% to 60% (p = 0.026), and twelve-month retention declined from 86% to 69%, due to increases in 12-month mortality from 2%-4% and LTFU from 12%-28%. In univariate analysis, year of ART initiation was associated with increasing rates of both LTFU and mortality. Controlling for baseline CD4, weight, adherence, and other risk factors, year of ART initiation was still strongly associated with LTFU but not mortality. In multivariate analysis, weight <45 kg and adherence <95% remained strong predictors of LTFU and mortality. Conclusions: During 2004-2007, increasing prevalence among ART enrollees of measured mortality risk factors, including weight <45 kg and ART adherence <95%, might explain increases in mortality over time. However, the association between later calendar year and increasing LTFU is not explained by risk factors evaluated in this analysis. Undocumented transfers, political instability, and patient dissatisfaction with crowded facilities might explain increasing LTFU. C1 [Auld, Andrew F.; Shiraishi, Ray W.; Sabatier, Jennifer; Ellerbrock, Tedd V.] Ctr Dis Control & Prevent, Div Global HIV AIDS, Atlanta, GA 30333 USA. [Ekra, Kunomboa A.] Ctr Dis Control & Prevent, Div Global HIV AIDS, Abidjan, Cote Ivoire. [Tuho, Moise Z.; Ettiegne-Traore, Virginie] Minist Hlth, Natl Program Med Care Persons Living HIV AIDS, Abidjan, Cote Ivoire. [Kouakou, Joseph S.; Mohamed, Fayama; Essombo, Joseph] Elizabeth Glaser Pediat AIDS Fdn, Abidjan, Cote Ivoire. [Mohamed, Fayama] Directorate Gen Budget & Finance, Dept Econ & Finance, Abidjan, Cote Ivoire. [Adjorlolo-Johnson, Georgette; Marlink, Richard] Elizabeth Glaser Pediat AIDS Fdn, Los Angeles, CA USA. RP Auld, AF (reprint author), Ctr Dis Control & Prevent, Div Global HIV AIDS, Atlanta, GA 30333 USA. EM aauld@cdc.gov OI Auld, Andrew/0000-0001-5089-9163 FU President's Emergency Plan for AIDS Relief (PEPFAR) through the United States Centers for Disease Control and Prevention (CDC) FX This research has been supported by the President's Emergency Plan for AIDS Relief (PEPFAR) (http://www.pepfar.gov/) through the United States Centers for Disease Control and Prevention (CDC) (http://www.cdc.gov/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 78 TC 7 Z9 7 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 27 PY 2014 VL 9 IS 5 AR e98183 DI 10.1371/journal.pone.0098183 PG 16 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AI5NG UT WOS:000336914100038 PM 24866468 ER PT J AU Miller, AH Jones, JF Drake, DF Tian, H Unger, ER Pagnoni, G AF Miller, Andrew H. Jones, James F. Drake, Daniel F. Tian, Hao Unger, Elizabeth R. Pagnoni, Giuseppe TI Decreased Basal Ganglia Activation in Subjects with Chronic Fatigue Syndrome: Association with Symptoms of Fatigue SO PLOS ONE LA English DT Article ID DEEP-BRAIN-STIMULATION; INTERFERON-ALPHA; PARKINSONS-DISEASE; FUNCTIONAL-ANATOMY; GLOBUS-PALLIDUS; DISORDERS; REWARD; CIRCUITS; PATHOGENESIS; DEFINITION AB Reduced basal ganglia function has been associated with fatigue in neurologic disorders, as well as in patients exposed to chronic immune stimulation. Patients with chronic fatigue syndrome (CFS) have been shown to exhibit symptoms suggestive of decreased basal ganglia function including psychomotor slowing, which in turn was correlated with fatigue. In addition, CFS patients have been found to exhibit increased markers of immune activation. In order to directly test the hypothesis of decreased basal ganglia function in CFS, we used functional magnetic resonance imaging to examine neural activation in the basal ganglia to a reward-processing (monetary gambling) task in a community sample of 59 male and female subjects, including 18 patients diagnosed with CFS according to 1994 CDC criteria and 41 non-fatigued healthy controls. For each subject, the average effect of winning vs. losing during the gambling task in regions of interest (ROI) corresponding to the caudate nucleus, putamen, and globus pallidus was extracted for group comparisons and correlational analyses. Compared to non-fatigued controls, patients with CFS exhibited significantly decreased activation in the right caudate (p = 0.01) and right globus pallidus (p = 0.02). Decreased activation in the right globus pallidus was significantly correlated with increased mental fatigue (r(2) = 0.49, p = 0.001), general fatigue (r(2) = 0.34, p = 0.01) and reduced activity (r(2) = 0.29, p = 0.02) as measured by the Multidimensional Fatigue Inventory. No such relationships were found in control subjects. These data suggest that symptoms of fatigue in CFS subjects were associated with reduced responsivity of the basal ganglia, possibly involving the disruption of projections from the globus pallidus to thalamic and cortical networks. C1 [Miller, Andrew H.; Drake, Daniel F.] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA. [Jones, James F.; Tian, Hao; Unger, Elizabeth R.] Ctr Dis Control & Prevent, Chron Viral Dis Branch, Atlanta, GA USA. [Pagnoni, Giuseppe] Univ Modena & Reggio Emilia, Dept Neurosci, Modena, Italy. RP Miller, AH (reprint author), Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA. EM amill02@emory.edu RI Pagnoni, Giuseppe/F-3398-2015 OI Pagnoni, Giuseppe/0000-0002-8272-8091 FU Centers for Disease Control and Prevention FX This study was funded by the Centers for Disease Control and Prevention. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 51 TC 8 Z9 8 U1 3 U2 11 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 23 PY 2014 VL 9 IS 5 AR e98156 DI 10.1371/journal.pone.0098156 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AI4ML UT WOS:000336839400047 PM 24858857 ER PT J AU Nelson, NP Murphy, TV McMahon, BJ AF Nelson, Noele P. Murphy, Trudy V. McMahon, Brian J. TI Hepatitis A vaccination for post-exposure prophylaxis in persons aged 40 years and older SO VACCINE LA English DT Letter C1 [Nelson, Noele P.; Murphy, Trudy V.] Ctr Dis Control & Prevent, Div Viral Hepatitis, Vaccine Res & Policy Team, Natl Ctr HIVAIDS Viral Hepatitis STD & TB Prevent, Atlanta, GA USA. [McMahon, Brian J.] Alaska Native Tribal Hlth Consortium, Liver Dis & Hepatitis Program, Alaska Native Med Ctr, Anchorage, AK 99508 USA. RP McMahon, BJ (reprint author), Alaska Native Tribal Hlth Consortium, Liver Dis & Hepatitis Program, Alaska Native Med Ctr, Anchorage, AK 99508 USA. EM nnelson@cdc.gov; tkm4@cdc.gov; bmcmahon@anthc.org OI Nelson, Noele/0000-0001-9831-0717 FU Intramural CDC HHS [CC999999] NR 4 TC 2 Z9 2 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD MAY 23 PY 2014 VL 32 IS 25 BP 2939 EP 2939 DI 10.1016/j.vaccine.2014.01.086 PG 1 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AI2UG UT WOS:000336713000001 PM 24530928 ER PT J AU Daley, MF Yih, WK Glanz, JM Hambidge, SJ Narwaney, KJ Yin, RH Li, LL Nelson, JC Nordin, JD Klein, NP Jacobsen, SJ Weintraub, E AF Daley, Matthew F. Yih, W. Katherine Glanz, Jason M. Hambidge, Simon J. Narwaney, Komal J. Yin, Ruihua Li, Lingling Nelson, Jennifer C. Nordin, James D. Klein, Nicola P. Jacobsen, Steven J. Weintraub, Eric TI Safety of diphtheria, tetanus, acellular pertussis and inactivated poliovirus (DTaP-IPV) vaccine SO VACCINE LA English DT Article DE Vaccine safety; Immunization; Vaccine; Surveillance; Diphtheria; Tetanus; Acellular pertussis; Inactivated poliovirus combined vaccine ID STEVENS-JOHNSON-SYNDROME; EVENT REPORTING SYSTEM; PROBABILITY RATIO TEST; ADVERSE EVENTS; IMMUNIZATION SAFETY; ACTIVE SURVEILLANCE; UNITED-STATES; RISK; CHILDREN; DATALINK AB Background: In 2008, a diphtheria, tetanus, acellular pertussis, and inactivated poliovirus combined vaccine (DTaP-IPV) was licensed for use in children 4 through 6 years of age. While pre-licensure studies did not demonstrate significant safety concerns, the number vaccinated in these studies was not sufficient to examine the risk of uncommon but serious adverse events. Objective: To assess the risk of serious adverse events following DTaP-IPV vaccination. Methods: The study was conducted from January 2009 through September 2012 in the Vaccine Safety Datalink (VSD) project. In the VSD, electronic vaccination and encounter data are updated and aggregated weekly as part of ongoing surveillance activities. Based on previous reports and biologic plausibility, eight potential adverse events were monitored: meningitis/encephalitis; seizures; stroke; Guillain-Barre syndrome; Stevens-Johnson syndrome; anaphylaxis; serious allergic reactions other than anaphylaxis; and serious local reactions. Adverse event rates in DTaP-IPV recipients were compared to historical incidence rates in the VSD population prior to 2009. Sequential probability ratio testing was used to analyze the data on a weekly basis. Results: During the study period, 201,116 children received DTaP-IPV vaccine. Ninety-seven percent of DTaP-IPV recipients also received other vaccines on the same day, typically measles-mumps-rubella and varicella vaccines. There was no statistically significant increased risk of any of the eight pre-specified adverse events among DTaP-IPV recipients when compared to historical incidence rates. Conclusions: In this safety surveillance study of more than 200,000 DTaP-IPV vaccine recipients, there was no evidence of increased risk for any of the pre-specified adverse events monitored. Continued surveillance of DTaP-IPV vaccine safety may be warranted to monitor for rare adverse events, such as Guillain-Barre syndrome. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Daley, Matthew F.; Glanz, Jason M.; Hambidge, Simon J.; Narwaney, Komal J.] Kaiser Permanente Colorado, Inst Hlth Res, Denver, CO 80231 USA. [Daley, Matthew F.; Hambidge, Simon J.] Univ Colorado, Sch Med, Dept Pediat, Aurora, CO 80045 USA. [Yih, W. Katherine; Yin, Ruihua; Li, Lingling] Harvard Univ, Sch Med, Dept Populat Med, Boston, MA 02215 USA. [Yih, W. Katherine; Yin, Ruihua; Li, Lingling] Harvard Pilgrim Hlth Care Inst, Boston, MA 02215 USA. [Hambidge, Simon J.] Denver Hlth, Community Hlth Serv, Denver, CO 80204 USA. [Nelson, Jennifer C.] Grp Hlth Res Inst, Biostat Unit, Seattle, WA 98101 USA. [Nelson, Jennifer C.] Univ Washington, Dept Biostat, Seattle, WA 98105 USA. [Nordin, James D.] HealthPartners Inst Educ & Res, Minneapolis, MN 55440 USA. [Klein, Nicola P.] Kaiser Permanente No Calif, Div Res, Oakland, CA 94612 USA. [Jacobsen, Steven J.] Kaiser Permanente So Calif, Dept Res & Evaluat, Pasadena, CA 91101 USA. [Weintraub, Eric] Ctr Dis Control & Prevent, Immunizat Safety Off, Atlanta, GA 30333 USA. RP Daley, MF (reprint author), Kaiser Permanente Colorado, Inst Hlth Res, 10065 E Harvard Ave 300, Denver, CO 80231 USA. EM matthew.f.daley@kp.org; katherine_yih@harvardpilgrim.org; jason.m.glanz@kp.org; simon.hambidge@dhha.org; komal.j.narwaney@kp.org; ryin1000@yahoo.com; lingling_li@harvardpilgrim.org; nelson.jl@ghc.org; james.d.nordin@healthpartner.scom; nicola.klein@kp.org; steven.j.jacobsen@kp.org; eiw8@cdc.gov OI Jacobsen, Steven/0000-0002-8174-8533 FU Vaccine Safety Surveillance and Assessment Projects [200-2002-00732]; American's Health Insurance Plans; Centers for Disease Control and Prevention (CDC) FX This study was supported through the Vaccine Safety Surveillance and Assessment Projects contract (contract #200-2002-00732) with American's Health Insurance Plans, funded by the Centers for Disease Control and Prevention (CDC). CDC co-authors were involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and review and approval of the manuscript. NR 38 TC 6 Z9 6 U1 1 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD MAY 23 PY 2014 VL 32 IS 25 BP 3019 EP 3024 DI 10.1016/j.vaccine.2014.03.063 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AI2UG UT WOS:000336713000016 PM 24699471 ER PT J AU Cotes-Cantillo, K Paternina-Caicedo, A Coronell-Rodriguez, W Alvis-Guzman, N Parashar, UD Patel, M De la Hoz-Restrepo, F AF Cotes-Cantillo, Karol Paternina-Caicedo, Angel Coronell-Rodriguez, Wilfrido Alvis-Guzman, Nelson Parashar, Umesh D. Patel, Manish De la Hoz-Restrepo, Fernando TI Effectiveness of the monovalent rotavirus vaccine in Colombia: A case-control study SO VACCINE LA English DT Article DE Rotavirus; Vaccine; Diarrhea; Vaccine effectiveness ID UNITED-STATES; EFFICACY; GASTROENTERITIS; CHILDREN; DISEASE; MORTALITY; DIARRHEA; SAFETY AB Objective: To assess the effectiveness of the monovalent rotavirus vaccine (RV1) to prevent rotavirus diarrhea admissions to emergency departments (ED) in Colombia. Methods: A multicenter case-control study was carried out in six Colombian cities from 2011 to January, 2013. Cases were laboratory confirmed rotavirus diarrhea patients admitted to ED of selected health centers. Controls were patients with non-rotavirus diarrhea. Vaccination status was card-confirmed. Vaccine effectiveness and 95% confidence intervals (Cl) were calculated from the conditional logistic regression models using the formula 1 - adjusted odds ratio x 100. Results: 1051 fecal samples were collected from 193 cases and 858 controls. Vaccination history was confirmed on 173 cases (90%) and 801 controls (93%). Among the rotavirus-positive samples with vaccination history, 57% were G2P[4], 9.8% G9P[8], 6% G9P[6]. Median age of cases (17 months) was greater than controls (15 months) (P < 0.001), and mothers of cases had lower level of education (P = 0.025). The adjusted effectiveness was 79.19% (95% CI, 23.7 to 94.32) among children 6-11 months of age and -39.75% (95% CI, -270.67 to 47.24) among those >12 months of age. Against overnight rotavirus hospitalizations, RV1 provided protection of 84.42% (95% CI, 22.68 to 96.86) among children 6-11 months of age, and -79.49% (95% CI, -555.8 to 51.08) among those >12 months. Conclusions: RV1 provided significant protection against rotavirus hospitalization among children under 1 year of age in the Colombian setting. The observation of lower effectiveness in children >12 months requires further assessment. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Cotes-Cantillo, Karol; De la Hoz-Restrepo, Fernando] Univ Nacl Colombia, Bogota, Colombia. [Paternina-Caicedo, Angel; Coronell-Rodriguez, Wilfrido; Alvis-Guzman, Nelson] Univ Cartagena, Grp Invest Econ Salud, Cartagena De Indias, Bolivar, Colombia. [Parashar, Umesh D.; Patel, Manish] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Paternina-Caicedo, A (reprint author), Univ Cartagena, Fac Ciencias Econ, Sede Piedra Bolivar, Calle 30 48-152,Bloque B,Sotano 1, Cartagena De Indias, Bolivar, Colombia. EM angel.paternina@gmail.com RI Paternina-Caicedo, Angel/N-4496-2015 OI Paternina-Caicedo, Angel/0000-0002-6332-5174 FU Administrative Department of Science Technology and Innovation of Colombia (COLCIENCIAS) [304] FX This study was funded by Administrative Department of Science Technology and Innovation of Colombia (COLCIENCIAS) through contract 304, 2010. NR 24 TC 9 Z9 11 U1 0 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD MAY 23 PY 2014 VL 32 IS 25 BP 3035 EP 3040 DI 10.1016/j.vaccine.2014.03.064 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AI2UG UT WOS:000336713000018 PM 24699470 ER PT J AU Khodyakov, D Uscher-Pines, L Lorick, SA Lindley, MC Shier, V Harris, K AF Khodyakov, Dmitry Uscher-Pines, Lori Lorick, Suchita A. Lindley, Megan C. Shier, Victoria Harris, Katherine TI A qualitative analysis of the impact of healthcare personnel influenza vaccination requirements in California SO VACCINE LA English DT Article DE Health care personnel; Influenza vaccination; Mandatory vaccination; State influenza vaccination requirements of healthcare personnel ID INSTITUTIONAL REQUIREMENTS; UNITED-STATES; HOSPITALS; WORKERS; LAW AB Objective: Using qualitative methods, we explored the implementation of California's 2007 influenza immunization requirements of hospital-based health care personnel (HCP). Methods: We conducted nine case studies of California hospitals with different HCP vaccination rates and policies. Case studies consisted of interviewing 13 hospital representatives and analyzing relevant hospital documents, including influenza policies. We also conducted 13 semi-structured phone interviews with key state and county public health officials, union representatives, and officials of various professional healthcare organizations. Results: Our qualitative results suggest that California's vaccination requirements likely did not increase influenza vaccination uptake among HCP. The law was not strong enough to compel hospitals with low and medium vaccination rates to improve their vaccination efforts, and hospitals with high vaccination rates were able to comply fully with the law by continuing to do what they were already doing - namely offering vaccinations to HCP, providing education about the risks of influenza and the benefits of vaccination, and obtaining signed declinations from those who refuse vaccination. Nonetheless, we found that by publicly raising the issue of influenza vaccination in the context of public safety and healthcare quality, California's law encouraged hospitals to develop and implement data systems to monitor the effectiveness of vaccination promotion efforts and prompted discussions, and, in some cases, adoption of stricter vaccination requirements at hospital or county levels. Conclusions: Our findings generally support the literature that suggests that permissive influenza vaccination requirements, though politically feasible, provide little direct incentive for hospitals to focus efforts on increasing HCP vaccination rates. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Khodyakov, Dmitry; Shier, Victoria] RAND Corp, Santa Monica, CA 90401 USA. [Uscher-Pines, Lori; Harris, Katherine] RAND Corp, Arlington, VA USA. [Lorick, Suchita A.; Lindley, Megan C.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Khodyakov, D (reprint author), RAND Corp, 1776 Main St,POB 2138, Santa Monica, CA 90401 USA. EM Dmitry_Khodyakov@rand.org FU Centers for Disease Control and Prevention [U01 IP000416] FX This journal article was supported by the Cooperative Agreement Number U01 IP000416 from the Centers for Disease Control and Prevention. Its contents are solely the responsibility of the authors and do not represent the official views of the Centers for Disease Control and Prevention. NR 41 TC 2 Z9 2 U1 1 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD MAY 23 PY 2014 VL 32 IS 25 BP 3082 EP 3087 DI 10.1016/j.vaccine.2013.06.077 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AI2UG UT WOS:000336713000024 PM 23845810 ER PT J AU Davila-Payan, C Swann, J Wortley, PM AF Davila-Payan, Carlo Swann, Julie Wortley, Pascale M. TI System factors to explain H1N1 state vaccination rates for adults in US emergency response to pandemic SO VACCINE LA English DT Article DE Pandemic; Coverage; State-specific; Factors; Estimates; Adults ID UNITED-STATES; INFLUENZA VACCINATION; WATER FLUORIDATION; TOOTH-DECAY; PREDICTORS; COVERAGE; ACCEPTANCE; CHILDREN AB Introduction: During the 2009-2010 H1N1 pandemic, vaccine in short supply was allocated to states pro rata by population, yet the vaccination rates of adults differed by state. States also differed in their campaign processes and decisions. Analyzing the campaign provides an opportunity to identify specific approaches that may result in higher vaccine uptake in a future event of this nature. Objective: To determine supply chain and system factors associated with higher state H1N1 vaccination coverage for adults in a system where vaccine was in short supply. Methods: Regression analysis of factors predicting state-specific H1N1 vaccination coverage in adults. Independent variables included state campaign information, demographics, preventive or health-seeking behavior, preparedness funding, providers, state characteristics, and H1N1-specific state data. Results: The best model explained the variation in state-specific adult vaccination coverage with an adjusted R-squared of 0.76. We found that higher H1N1 coverage of adults is associated with program aspects including shorter lead-times (i.e., the number of days between when doses were allocated to a state and were shipped, including the time for states to order the doses) and less vaccine directed to specialist locations. Higher vaccination coverage is also positively associated with the maximum number of ship-to locations, past seasonal influenza vaccination coverage, the percentage of women with a Pap smear, the percentage of the population that is Hispanic, and negatively associated with a long duration of the epidemic peak. Conclusion: Long lead-times may be a function of system structure or of efficiency and may suggest monitoring or redesign of distribution processes. Sending vaccine to sites with broad access could be useful when covering a general population. Existing infrastructure may be reflected in the maximum number of ship-to locations, so strengthening routine influenza vaccination programs may help during emergency vaccinations also. Future research could continue to inform program decisions. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved. C1 [Davila-Payan, Carlo; Swann, Julie] Georgia Inst Technol, Sch Ind & Syst Engn, Atlanta, GA 30332 USA. [Swann, Julie] Georgia Inst Technol, Sch Publ Policy, Atlanta, GA 30332 USA. [Wortley, Pascale M.] Ctr Dis Control & Prevent, Immunizat Serv Div, Atlanta, GA 30329 USA. RP Swann, J (reprint author), Georgia Inst Technol, Sch Ind & Syst Engn, 755 Ferst Dr, Atlanta, GA 30332 USA. EM carlo.davila@gatech.edu; jswann@isye.gatech.edu; pmw1@cdc.gov OI Davila Payan, Carlo/0000-0003-0722-4587; Swann, Julie/0000-0003-2151-4396 FU Centers for Disease Control and Prevention (CDC) FX C. Davila-Payan collected data, performed statistical analysis, and aided in drafting the manuscript. J. Swann designed the study, advised on methodology and logistical factors, and drafted the manuscript. P. Wortley advised on public health and vaccination programs, assisted in acquisition of data, aided in interpretation of results, and editing the manuscript. All authors approved the final manuscript. C. Davila-Payan was partially supported by the ORISE Fellows program during the research. J. Swann was partially supported as the Harold R. and Mary Anne Nash professor, by the Zalesky Family, and by Andrea Laliberte in gifts to the Georgia Institute of Technology, and was partially supported by the Centers for Disease Control and Prevention (CDC) in an Intergovernmental Personnel Act agreement between the CDC and Georgia Tech. The ORISE Fellows program and the donors to Georgia Tech had no role in this research. Participants at the CDC gave feedback on preliminary results including potential interpretations and reviewed the final manuscript for confidentiality and accuracy. The findings and conclusions in this paper are those of the authors and do not necessarily represent the official position of the CDC. NR 41 TC 0 Z9 0 U1 1 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD MAY 23 PY 2014 VL 32 IS 25 BP 3088 EP 3093 DI 10.1016/j.vaccine.2013.05.069 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AI2UG UT WOS:000336713000025 PM 23727421 ER PT J AU Harrison, C Jorder, M Stern, H Stavinsky, F Reddy, V Hanson, H Waechter, H Lowe, L Gravano, L Balter, S AF Harrison, Cassandra Jorder, Mohip Stern, Henri Stavinsky, Faina Reddy, Vasudha Hanson, Heather Waechter, HaeNa Lowe, Luther Gravano, Luis Balter, Sharon TI Using Online Reviews by Restaurant Patrons to Identify Unreported Cases of Foodborne Illness - New York City, 2012-2013 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Harrison, Cassandra; Stavinsky, Faina; Reddy, Vasudha; Hanson, Heather; Waechter, HaeNa; Balter, Sharon] New York City Dept Hlth & Mental Hyg, New York, NY 10013 USA. [Harrison, Cassandra] CDC, Atlanta, GA 30333 USA. [Jorder, Mohip; Stern, Henri; Gravano, Luis] Columbia Univ, New York, NY 10027 USA. [Lowe, Luther] Yelp, San Francisco, CA USA. RP Reddy, V (reprint author), New York City Dept Hlth & Mental Hyg, New York, NY 10013 USA. EM vreddy@health.nyc.gov NR 9 TC 10 Z9 10 U1 1 U2 4 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAY 23 PY 2014 VL 63 IS 20 BP 441 EP 445 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AH9ND UT WOS:000336468200001 PM 24848215 ER PT J AU Wallace, RM Bhavnani, D Russell, J Zaki, S Muehlenbachs, A Hayden-Pinneri, K Aplicano, RM Peruski, L Vora, NM Elson, D Lederman, E Leeson, B McLaughlin, T Waterman, S Fonseca-Ford, M Blanton, J Franka, R Velasco-Villa, A Niezgoda, M Orciari, L Recuenco, S Damon, I Hanlon, C Jackson, F Dyer, J Wadhwa, A Robinson, L AF Wallace, Ryan M. Bhavnani, Darlene Russell, John Zaki, Sherif Muehlenbachs, Atis Hayden-Pinneri, Kathryn Aplicano, Ricardo Mena Peruski, Leonard Vora, Neil M. Elson, Diana Lederman, Edith Leeson, Ben McLaughlin, Thomas Waterman, Steve Fonseca-Ford, Maureen Blanton, Jesse Franka, Richard Velasco-Villa, Andres Niezgoda, Michael Orciari, Lillian Recuenco, Sergio Damon, Inger Hanlon, Cathleen Jackson, Felix Dyer, Jessie Wadhwa, Ashutosh Robinson, Laura TI Rabies Death Attributed to Exposure in Central America with Symptom Onset in a US Detention Facility - Texas, 2013 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Wallace, Ryan M.; Vora, Neil M.] CDC, Atlanta, GA 30333 USA. [Bhavnani, Darlene; Fonseca-Ford, Maureen; Blanton, Jesse] CDC, Div Global Migrat & Quarantine, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Russell, John; Leeson, Ben; McLaughlin, Thomas] Christus Spohn Hosp, Texas A&M Hlth Sci Ctr, Corpus Christi, TX USA. [Zaki, Sherif; Muehlenbachs, Atis; Waterman, Steve; Franka, Richard; Velasco-Villa, Andres; Niezgoda, Michael; Orciari, Lillian; Recuenco, Sergio; Damon, Inger; Hanlon, Cathleen; Jackson, Felix; Dyer, Jessie; Wadhwa, Ashutosh] CDC, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Hayden-Pinneri, Kathryn] Harris Cty Med Examiners Off, Houston, TX USA. [Aplicano, Ricardo Mena] Guatemala Minist Hlth, Guatemala City, Guatemala. [Peruski, Leonard] CDC, Div Global Hlth Protect, Ctr Global Hlth, Atlanta, GA 30333 USA. [Elson, Diana; Lederman, Edith] Publ Hlth Safety & Preparedness Unit, Yuba, CA USA. [Robinson, Laura] Texas Dept State Hlth Serv, Austin, TX USA. RP Wallace, RM (reprint author), CDC, Atlanta, GA 30333 USA. EM euk5@cdc.gov OI Recuenco-Cabrera, Sergio/0000-0002-8446-7411 NR 7 TC 3 Z9 3 U1 0 U2 1 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAY 23 PY 2014 VL 63 IS 20 BP 446 EP 449 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AH9ND UT WOS:000336468200002 PM 24848216 ER PT J AU Marsden-Haug, N Hill, H Litvintseva, AP Engelthaler, DM Driebe, EM Roe, CC Ralston, C Hurst, S Goldoft, M Gade, L Wohrle, R Thompson, GR Brandt, ME Chiller, T AF Marsden-Haug, Nicola Hill, Heather Litvintseva, Anastasia P. Engelthaler, David M. Driebe, Elizabeth M. Roe, Chandler C. Ralston, Cindy Hurst, Steven Goldoft, Marcia Gade, Lalitha Wohrle, Ron Thompson, George R., III Brandt, Mary E. Chiller, Tom TI Coccidioides immitis Identified in Soil Outside of Its Known Range - Washington, 2013 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Marsden-Haug, Nicola; Goldoft, Marcia; Wohrle, Ron] Univ Calif Davis, Coccidioidomycosis Serol Lab, Davis, CA 95616 USA. [Hill, Heather; Ralston, Cindy] Benton Franklin Hlth Dist, Kennewick, WA USA. [Litvintseva, Anastasia P.; Hurst, Steven; Gade, Lalitha; Brandt, Mary E.; Chiller, Tom] CDC, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Engelthaler, David M.; Driebe, Elizabeth M.; Roe, Chandler C.] Translat Genom Res Inst, Flagstaff, AZ USA. [Thompson, George R., III] Univ Calif Davis, Coccidioidomycosis Serol Lab, Davis, CA USA. RP Marsden-Haug, N (reprint author), Univ Calif Davis, Coccidioidomycosis Serol Lab, Davis, CA 95616 USA. EM nicola.marsden-haug@doh.wa.gov NR 1 TC 9 Z9 9 U1 0 U2 3 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAY 23 PY 2014 VL 63 IS 20 BP 450 EP 450 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AH9ND UT WOS:000336468200003 PM 24848217 ER PT J AU Greene, YG Padovani, T Rudroff, JA Hall, R Austin, C Vernon, M AF Greene, Yoran Grant Padovani, Thomas Rudroff, Jo Ann Hall, Rebecca Austin, Connie Vernon, Michael TI Trichinellosis Caused by Consumption of Wild Boar Meat - Illinois, 2013 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Greene, Yoran Grant] CDC, Atlanta, GA 30333 USA. [Greene, Yoran Grant; Austin, Connie; Vernon, Michael] Illinois Dept Publ Hlth, Springfield, IL 62761 USA. [Padovani, Thomas] Cook Cty Dept Publ Hlth, Chicago, IL USA. [Rudroff, Jo Ann] Missouri Dept Hlth & Senior Serv, Jefferson City, MO USA. [Hall, Rebecca] CDC, Div Parasit & Malarial Dis, Ctr Global Hlth, Atlanta, GA 30333 USA. RP Greene, YG (reprint author), CDC, Atlanta, GA 30333 USA. EM exu4@cdc.gov NR 2 TC 3 Z9 3 U1 0 U2 3 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAY 23 PY 2014 VL 63 IS 20 BP 451 EP 451 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AH9ND UT WOS:000336468200004 PM 24848218 ER PT J AU Reynolds, CA Finkelstein, JA Ray, GT Moore, MR Huang, SS AF Reynolds, Courtney A. Finkelstein, Jonathan A. Ray, G. Thomas Moore, Matthew R. Huang, Susan S. TI Attributable healthcare utilization and cost of pneumoniae due to drug-resistant Streptococcus pneumoniae: a cost analysis SO ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL LA English DT Article DE Streptococcus pneumoniae; Antibiotic resistance; Healthcare utilization; DRSP ID INVASIVE PNEUMOCOCCAL DISEASE; COMMUNITY-ACQUIRED PNEUMONIA; POLYSACCHARIDE VACCINE; CONJUGATE VACCINE; UNITED-STATES; CHILDREN; ADULTS; REPLACEMENT; GUIDELINES; MANAGEMENT AB Background: The burden of disease due to S. pneumoniae (pneumococcus), particularly pneumonia, remains high despite the widespread use of vaccines. Drug resistant strains complicate clinical treatment and may increase costs. We estimated the annual burden and incremental costs attributable to antibiotic resistance in pneumococcal pneumonia. Methods: We derived estimates of healthcare utilization and cost (in 2012 dollars) attributable to penicillin, erythromycin and fluoroquinolone resistance by taking the estimate of disease burden from a previously described decision tree model of pneumococcal pneumonia in the U.S. We analyzed model outputs assuming only the existence of susceptible strains and calculating the resulting differences in cost and utilization. We modeled the cost of resistance from delayed resolution of illness and the resulting additional health services. Results: Our model estimated that non-susceptibility to penicillin, erythromycin and fluoroquinolones directly caused 32,398 additional outpatient visits and 19,336 hospitalizations for pneumococcal pneumonia. The incremental cost of antibiotic resistance was estimated to account for 4% ($91 million) of direct medical costs and 5% ($233 million) of total costs including work and productivity loss. Most of the incremental medical cost ($82 million) was related to hospitalizations resulting from erythromycin non-susceptibility. Among patients under age 18 years, erythromycin non-susceptibility was estimated to cause 17% of hospitalizations for pneumonia and $38 million in costs, or 39% of pneumococcal pneumonia costs attributable to resistance. Conclusions: We estimate that antibiotic resistance in pneumococcal pneumonia leads to substantial healthcare utilization and cost, with more than one-third driven by macrolide resistance in children. With 5% of total pneumococcal costs directly attributable to resistance, strategies to reduce antibiotic resistance or improve antibiotic selection could lead to substantial savings. C1 [Reynolds, Courtney A.; Huang, Susan S.] Univ Calif Irvine, Sch Med, Div Infect Dis, Irvine, CA 92697 USA. [Reynolds, Courtney A.; Huang, Susan S.] Univ Calif Irvine, Sch Med, Hlth Policy Res Inst, Irvine, CA 92697 USA. [Finkelstein, Jonathan A.] Harvard Univ, Sch Med, Dept Populat Med, Boston, MA 02215 USA. [Finkelstein, Jonathan A.] Harvard Pilgrim Hlth Care Inst, Boston, MA 02215 USA. [Finkelstein, Jonathan A.] Boston Childrens Hosp, Div Gen Pediat, Boston, MA 02115 USA. [Ray, G. Thomas] Kaiser Permanente, Div Res, Oakland, CA 94612 USA. [Moore, Matthew R.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Reynolds, CA (reprint author), Univ Calif Irvine, Sch Med, Div Infect Dis, 100 Theory Ave,Suite 110, Irvine, CA 92697 USA. EM courtner@uci.edu FU Centers for Disease Control and Prevention (CDC) [TS-1363] FX This study was funded by the Centers for Disease Control and Prevention (CDC) (TS-1363, Finkelstein). NR 24 TC 10 Z9 10 U1 2 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 2047-2994 J9 ANTIMICROB RESIST IN JI Antimicrob. Resist. Infect. Control PD MAY 21 PY 2014 VL 3 AR 16 DI 10.1186/2047-2994-3-16 PG 7 WC Public, Environmental & Occupational Health; Infectious Diseases; Microbiology SC Public, Environmental & Occupational Health; Infectious Diseases; Microbiology GA CZ6OG UT WOS:000367220000001 PM 24851182 ER PT J AU Li, W Li, YJ Li, WZ Yang, JP Song, MX Diao, RN Jia, HL Lu, YX Zheng, J Zhang, XC Xiao, LH AF Li, Wei Li, Yijing Li, Weizhi Yang, Jinping Song, Mingxin Diao, Ruinan Jia, Honglin Lu, Yixin Zheng, Jun Zhang, Xichen Xiao, Lihua TI Genotypes of Enterocytozoon bieneusi in Livestock in China: High Prevalence and Zoonotic Potential SO PLOS ONE LA English DT Article ID VIRUS-INFECTED PATIENTS; GIARDIA-DUODENALIS; MICROSPORIDIOSIS; ANIMALS; EPIDEMIOLOGY; IDENTIFICATION; PARASITES; THERAPY; SAMPLES; HUMANS AB Despite many recent advances in genotype characterization of Enterocytozoon bieneusi worldwide and the exploration of the extent of cross-species transmission of microsporidiosis between humans and animals, the epidemiology of this neglected disease in China is poorly understood. In this study, a very high prevalence (60.3%; 94/156) of E. bieneusi infections in farmed pigs in Jilin province was detected by PCR of the ribosomal internal transcribed spacer (ITS). DNA sequence analysis of 88 E. bieneusi-positive specimens identified 12 distinct genotypes (11 known: CHN7, CS-1, CS-4, CS-6, EbpA, EbpB, EbpC, EbpD, EBITS3, G, and Henan-I; one novel: CS-9). Frequent appearance of mixed genotype infections was seen in the study animals. Weaned (74.6%; 53/71) or pre-weaned (68.8%; 22/32) pigs have infection rates significantly higher than growing pigs (35.8%; 19/53) (p<0.01). Likewise, E. bieneusi was detected in 2 of 45 sheep fecal specimens (4.4%) in Heilongjiang province, belonging to the known genotype BEB6. Genotypes EbpA, EbpC, EbpD, and Henan-I examined herein have been documented in the cases of human infections and BEB6, EbpA, EbpC, and EbpD in wastewater in central China. Infections of EbpA and EbpC in humans were also reported in other areas of the world. The other known genotypes (CHN7, CS-1, CS-4, CS-6, EBITS3, EbpB, and G) and the new genotype CS-9 were genetically clustered into a group of existing E. bieneusi genotypes with zoonotic potential. Thus, pigs could be a potential source of human E. bieneusi infections in China. C1 [Li, Wei; Jia, Honglin; Zheng, Jun] Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin, Heilongjiang, Peoples R China. [Li, Wei; Li, Yijing; Yang, Jinping; Song, Mingxin; Diao, Ruinan; Lu, Yixin] Northeast Agr Univ, Coll Vet Med, Harbin, Heilongjiang, Peoples R China. [Li, Weizhi; Zhang, Xichen] Jilin Univ, Coll Vet Med, Minist Educ, Key Lab Zoonosis Res, Changchun 130023, Jilin, Peoples R China. [Xiao, Lihua] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Atlanta, GA USA. RP Zhang, XC (reprint author), Jilin Univ, Coll Vet Med, Minist Educ, Key Lab Zoonosis Res, Changchun 130023, Jilin, Peoples R China. EM xczhang@jlu.edu.cn; lax0@cdc.gov RI Xiao, Lihua/B-1704-2013; OI Xiao, Lihua/0000-0001-8532-2727; Li, Wei/0000-0002-4264-1864 FU State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute [SKLVBF201307]; National Natural Science Foundation of China [31302081]; Natural Science Foundation of Heilongjiang Province [QC2013C015]; 54th Postdoctoral Scientific Foundation of China [2013M540266]; Heilongjiang Postdoctoral Research Fund [LBH-Z13024] FX This study was supported by the State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute (SKLVBF201307), the National Natural Science Foundation of China (No. 31302081), the Natural Science Foundation of Heilongjiang Province (No. QC2013C015), the 54th Postdoctoral Scientific Foundation of China (No. 2013M540266), and the Heilongjiang Postdoctoral Research Fund (No. LBH-Z13024). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 31 TC 20 Z9 20 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 20 PY 2014 VL 9 IS 5 AR e97623 DI 10.1371/journal.pone.0097623 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AM0UW UT WOS:000339563400040 PM 24845247 ER PT J AU Lobo, ML Augusto, J Antunes, F Ceita, J Xiao, LH Codices, V Matos, O AF Lobo, Maria Luisa Augusto, Joao Antunes, Francisco Ceita, Jose Xiao, Lihua Codices, Vera Matos, Olga TI Cryptosporidium spp., Giardia duodenalis, Enterocytozoon bieneusi and Other Intestinal Parasites in Young Children in Lobata Province, Democratic Republic of Sao Tome and Principe SO PLOS ONE LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; RANDOMIZED CONTROLLED-TRIAL; HIV-INFECTED PERSONS; MOLECULAR EPIDEMIOLOGY; SOUTH-AFRICA; CLINICAL-MANIFESTATIONS; ZOONOTIC TRANSMISSION; CHILDHOOD DIARRHEA; UGANDAN CHILDREN; PREVALENCE AB Rare systemic studies concerning prevalence of intestinal parasites in children have been conducted in the second smallest country in Africa, the Democratic Republic of Sao Tome and Principe. Fecal specimens from 348 children (214 in-hospital attending the Aires de Menezes Hospital and 134 from Agostinho Neto village) in Sao Tome Island were studied by parasitological and molecular methods. Of the 134 children from Agostinho Neto, 52.2% presented intestinal parasites. 32.1% and 20.2% of these children had monoparasitism and polyparasitism, respectively. Ascaris lumbricoides (27.6%), G. duodenalis (7.5%), T. trichiura (4.5%) and Entamoeba coli (10.5%) were the more frequent species identified in the children of this village. Giardia duodenalis (7.5%) and E. bieneusi (5.2%) were identified by PCR. Nested-PCR targeting G. duodenalis TPI identified Assemblage A (60%) and Assemblage B (40%). The E. bieneusi ITS-based sequence identified genotypes K (57.1%), KIN1 (28.6%) and KIN3 (14.3%). Among the 214 in-hospital children, 29.4% presented intestinal parasites. In 22.4% and 7.0% of the parasitized children, respectively, one or more species were concurrently detected. By microscopy, A. lumbricoides (10.3%) and Trichiuris trichiura (6.5%) were the most prevalent species among these children, and Cryptosporidium was detected by PCR in 8.9% of children. GP60 locus analysis identified 6.5% of C. hominis (subtypes IaA27R3 [35.7%], IaA23R3 [14.3%], IeA11G3T3 [28.6%] and IeA11G3T3R1 [21.4%]) and 2.3% of C. parvum (subtypes IIaA16G2R1 [20.0%], IIaA15G2R1 [20.0%], IIdA26G1 [40.0%] and IIdA21G1a [20.0%]). G. duodenalis and E. bieneusi were identified in 0.5% and 8.9% of the in-hospital children, respectively. G. duodenalis Assemblage B was characterized. The E. bieneusi genotypes K (52.6%), D (26.4%), A (10.5%) and KIN1 (10.5%) were identified. Although further studies are required to clarify the epidemiology of these infectious diseases in this endemic region the significance of the present results highlights that it is crucial to strength surveillance on intestinal pathogens. C1 [Lobo, Maria Luisa; Codices, Vera; Matos, Olga] Univ Nova Lisboa, Inst Higiene & Med Trop, Grp Protozoarios Oportunistas VIH & Outros Protoz, Unidade Parasitol Med,CMDT, P-1200 Lisbon, Portugal. [Augusto, Joao] Hosp Portimao, Ctr Hosp Algarve, Portimao, Portugal. [Antunes, Francisco] Univ Lisbon, Fac Med, P-1699 Lisbon, Portugal. [Ceita, Jose] Hosp Aires Menezes, Sao Tome, Sao Tome & Prin. [Xiao, Lihua] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Atlanta, GA USA. RP Matos, O (reprint author), Univ Nova Lisboa, Inst Higiene & Med Trop, Grp Protozoarios Oportunistas VIH & Outros Protoz, Unidade Parasitol Med,CMDT, P-1200 Lisbon, Portugal. EM omatos@ihmt.unl.pt RI Xiao, Lihua/B-1704-2013; Lobo, Maria/I-3527-2012; OI Xiao, Lihua/0000-0001-8532-2727; Lobo, Maria/0000-0001-5811-7568; Antunes, Francisco/0000-0001-7932-1154 NR 71 TC 9 Z9 10 U1 1 U2 9 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 20 PY 2014 VL 9 IS 5 AR e97708 DI 10.1371/journal.pone.0097708 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AM0UW UT WOS:000339563400047 PM 24846205 ER PT J AU Murphy, JL Haas, CN Arrowood, MJ Hlavsa, MC Beach, MJ Hill, VR AF Murphy, Jennifer L. Haas, Charles N. Arrowood, Michael J. Hlavsa, Michele C. Beach, Michael J. Hill, Vincent R. TI Efficacy of Chlorine Dioxide Tablets on Inactivation of Cryptosporidium Oocysts SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID ESCHERICHIA-COLI INACTIVATION; PARVUM OOCYSTS; SEQUENTIAL DISINFECTION; DRINKING-WATER; UNITED-STATES; OZONE; VIABILITY; ASSAYS; MONOCHLORAMINE; INFECTIVITY AB The ability of chlorine dioxide (ClO2) to achieve 2-log inactivation of Cryptosporidium in drinking water has been documented. No studies have specifically addressed the effects of ClO2 on C. parvum oocyst infectivity in chlorinated recreational water venues (e.g., pools). The aim of this research was to determine the efficacy of ClO2 as an alternative to existing hyperchlorination protocols that are used to achieve a 3-log inactivation of Cryptosporidium in such venues. To obtain a 3-log inactivation of C. parvum Iowa oocysts, contact times of 105 and 128 min for a solution containing 5 mg/L ClO2 with and without the addition of 2.6 mg/L free chlorine, respectively, were required. Contact times of 294 and 857 min for a solution containing 1.4 mg/L ClO2 with and without the addition of 3.6 mg/L free chlorine, respectively, were required. The hyperchlorination control (21 mg/L free chlorine only) required 455 min for a 3-log inactivation. Use of a solution containing S mg/L ClO2 and solutions containing 5 or 1.4 mg/L ClO2 with the addition of free chlorine appears to be a promising alternative to hyperchlorination for inactivating Cryptosporidium in chlorinated recreational water venues, but further studies are required to evaluate safety constraints on use. C1 [Murphy, Jennifer L.; Arrowood, Michael J.; Hlavsa, Michele C.; Beach, Michael J.; Hill, Vincent R.] Ctr Dis Control & Prevent, Waterborne Dis Prevent Branch, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30329 USA. [Haas, Charles N.] Drexel Univ, Philadelphia, PA 19104 USA. RP Murphy, JL (reprint author), Ctr Dis Control & Prevent, Waterborne Dis Prevent Branch, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30329 USA. EM iod7@cdc.gov FU Buena Vista Construction Company FX This study was supported in part by funding from Buena Vista Construction Company. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 41 TC 4 Z9 4 U1 4 U2 35 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD MAY 20 PY 2014 VL 48 IS 10 BP 5849 EP 5856 DI 10.1021/es500644d PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AH8VB UT WOS:000336415200060 PM 24797292 ER PT J AU Oberste, MS Lipton, HL AF Oberste, M. Steven Lipton, Howard L. TI Global polio perspective SO NEUROLOGY LA English DT Article ID VACCINE-DERIVED POLIOVIRUSES AB The results of the Global Polio Eradication Initiative that began in 1988 when there was transmission of 350,000 polio cases in 125 countries and has culminated in endemic transmission of only 223 polio cases in 3 countries in 2012 are reviewed. C1 [Oberste, M. Steven] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Lipton, Howard L.] Univ Illinois, Dept Microbiol & Immunol, Chicago, IL 60680 USA. RP Lipton, HL (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. EM hlipton@uic.edu FU NINDS (NIH) FX H.L.L. supported by grants from NINDS (NIH). NR 9 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0028-3878 EI 1526-632X J9 NEUROLOGY JI Neurology PD MAY 20 PY 2014 VL 82 IS 20 BP 1831 EP 1832 DI 10.1212/WNL.0000000000000426 PG 2 WC Clinical Neurology SC Neurosciences & Neurology GA AI3EN UT WOS:000336742700015 PM 24843034 ER PT J AU Li, J Berkowitz, Z Richards, TB Hall, IJ AF Li, Jun Berkowitz, Zahava Richards, Thomas B. Hall, Ingrid J. TI Prostate-specific antigen testing and shared decision making for prostate cancer screening SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract CT 50th Annual Meeting of the American-Society-of-Clinical-Oncology CY MAY 30-JUN 03, 2014 CL Chicago, IL SP Amer Soc Clin Oncol C1 [Li, Jun; Berkowitz, Zahava; Richards, Thomas B.; Hall, Ingrid J.] Ctr Dis Control, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2014 VL 32 IS 15 SU S MA e12512 PG 1 WC Oncology SC Oncology GA CN7KL UT WOS:000358613200145 ER PT J AU Lansky, A Finlayson, T Johnson, C Holtzman, D Wejnert, C Mitsch, A Gust, D Chen, R Mizuno, Y Crepaz, N AF Lansky, Amy Finlayson, Teresa Johnson, Christopher Holtzman, Deborah Wejnert, Cyprian Mitsch, Andrew Gust, Deborah Chen, Robert Mizuno, Yuko Crepaz, Nicole TI Estimating the Number of Persons Who Inject Drugs in the United States by Meta-Analysis to Calculate National Rates of HIV and Hepatitis C Virus Infections SO PLOS ONE LA English DT Article ID US METROPOLITAN-AREAS; USERS; POPULATION; PREVALENCE AB Background: Injection drug use provides an efficient mechanism for transmitting bloodborne viruses, including human immunodeficiency virus (HIV) and hepatitis C virus (HCV). Effective targeting of resources for prevention of HIV and HCV infection among persons who inject drugs (PWID) is based on knowledge of the population size and disparity in disease burden among PWID. This study estimated the number of PWID in the United States to calculate rates of HIV and HCV infection. Methods: We conducted meta-analysis using data from 4 national probability surveys that measured lifetime (3 surveys) or past-year (3 surveys) injection drug use to estimate the proportion of the United States population that has injected drugs. We then applied these proportions to census data to produce population size estimates. To estimate the disease burden among PWID by calculating rates of disease we used lifetime population size estimates of PWID as denominators and estimates of HIV and HCV infection from national HIV surveillance and survey data, respectively, as numerators. We calculated rates of HIV among PWID by gender-, age-, and race/ethnicity. Results: Lifetime PWID comprised 2.6% (95% confidence interval: 1.8%-3.3%) of the U. S. population aged 13 years or older, representing approximately 6,612,488 PWID (range: 4,583,188-8,641,788) in 2011. The population estimate of past-year PWID was 0.30% (95% confidence interval: 0.19 %-0.41%) or 774,434 PWID (range: 494,605-1,054,263). Among lifetime PWID, the 2011 HIV diagnosis rate was 55 per 100,000 PWID; the rate of persons living with a diagnosis of HIV infection in 2010 was 2,147 per 100,000 PWID; and the 2011 HCV infection rate was 43,126 per 100,000 PWID. Conclusion: Estimates of the number of PWID and disease rates among PWID are important for program planning and addressing health inequities. C1 [Lansky, Amy; Finlayson, Teresa; Johnson, Christopher; Wejnert, Cyprian; Mitsch, Andrew; Gust, Deborah; Chen, Robert; Mizuno, Yuko; Crepaz, Nicole] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Holtzman, Deborah] Ctr Dis Control & Prevent, Div Viral Hepatitis, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. RP Lansky, A (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. EM ALansky@cdc.gov NR 23 TC 39 Z9 39 U1 1 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 19 PY 2014 VL 9 IS 5 AR e97596 DI 10.1371/journal.pone.0097596 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AN9SK UT WOS:000340948600048 PM 24840662 ER PT J AU Wanzira, H Yeka, A Kigozi, R Rubahika, D Nasr, S Sserwanga, A Kamya, M Filler, S Dorsey, G Steinhardt, L AF Wanzira, Humphrey Yeka, Adoke Kigozi, Ruth Rubahika, Denis Nasr, Sussann Sserwanga, Asadu Kamya, Moses Filler, Scott Dorsey, Grant Steinhardt, Laura TI Long-lasting insecticide-treated bed net ownership and use among children under five years of age following a targeted distribution in central Uganda SO MALARIA JOURNAL LA English DT Article DE Malaria; Long-lasting insecticide-treated bed nets; Intervention coverage ID WESTERN KENYA; MALARIA TRANSMISSION; HOUSEHOLDS; MORBIDITY; MORTALITY; CAMPAIGN; INDEXES; AFRICA; DESIGN; IMPACT AB Background: Universal coverage of long-lasting insecticide-treated bed nets (LLINs) for prevention of malaria was adopted by the Uganda National Malaria Control Programme in 2007. The first mass distribution of LLINs was implemented in 2010. Initially, a campaign targeted to households with pregnant women and children aged = 15 000 cells/mu L within 1 day of positive test), severe outcome (intensive care unit admission after positive test, colectomy for C. difficile infection, or death within 30 days of positive test), and death within 14 days of positive test. Results. Strain typing results were available for 2057 cases. Severe disease occurred in 363 (17.7%) cases, severe outcome in 100 (4.9%), and death within 14 days in 56 (2.7%). The most common strain types were NAP1 (28.4%), NAP4 (10.2%), and NAP11 (9.1%). In unadjusted analysis, NAP1 was associated with greater odds of severe disease than other strains. After controlling for patient risk factors, healthcare exposure, and antibiotic use, NAP1 was associated with severe disease (adjusted odds ratio [AOR], 1.74; 95% confidence interval [CI], 1.36-2.22), severe outcome (AOR, 1.66; 95% CI, 1.09-2.54), and death within 14 days (AOR, 2.12; 95% CI, 1.22-3.68). Conclusions. NAP1 was the most prevalent strain and a predictor of severe disease, severe outcome, and death. Strategies to reduce NAP1 prevalence, such as antibiotic stewardship to reduce fluoroquinolone use, might reduce CDI morbidity. C1 [See, Isaac; Mu, Yi; Cohen, Jessica; Anderson, Lydia; Lessa, Fernanda C.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. [See, Isaac] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Cohen, Jessica] Atlanta Res & Educ Fdn, Atlanta, GA USA. [Beldavs, Zintars G.] Oregon Hlth Author, Portland, OR USA. [Winston, Lisa G.] Univ Calif San Francisco, Sch Med, San Francisco, CA USA. [Dumyati, Ghinwa] Univ Rochester, New York, NY USA. [Holzbauer, Stacy] Ctr Dis Control & Prevent, Minnesota Dept Hlth, St Paul, MN USA. [Dunn, John] Tennessee Dept Hlth, Nashville, TN USA. [Farley, Monica M.] Atlanta Vet Med Ctr, Atlanta, GA USA. [Farley, Monica M.] Emory Univ, Sch Med, Atlanta, GA 30322 USA. [Lyons, Carol] Connecticut Emerging Infect Program, New Haven, CT USA. [Johnston, Helen] Colorado Dept Publ Hlth & Environm, Denver, CO USA. [Phipps, Erin] Univ New Mexico, Albuquerque, NM 87131 USA. [Perlmutter, Rebecca] Maryland Emerging Infect Program, Baltimore, MD USA. [Gerding, Dale N.] Loyola Univ, Stritch Sch Med, Chicago, IL 60611 USA. [Gerding, Dale N.] Hines Vet Affairs Hosp, Chicago, IL USA. RP See, I (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, 1600 Clifton Rd NE A-24, Atlanta, GA 30333 USA. EM isee@cdc.gov FU CDC EIP [U50CK000201, U50CK000194, U50CK000195, U50CK000196, U50CK000203, U50CK000204, U50CK000205, U50CK000199, U50CK000197, U50CK000198] FX This work was supported by the CDC EIP Cooperative Agreement with California (U50CK000201), Colorado (U50CK000194), Connecticut (U50CK000195), Georgia (U50CK000196), Maryland (U50CK000203), Minnesota (U50CK000204), New Mexico (U50CK000205), New York (U50CK000199), Oregon (U50CK000197), and Tennessee (U50CK000198). NR 33 TC 46 Z9 46 U1 0 U2 6 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAY 15 PY 2014 VL 58 IS 10 BP 1394 EP 1400 DI 10.1093/cid/ciu125 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AH3RZ UT WOS:000336044200011 PM 24604900 ER PT J AU Behravesh, CB Brinson, D Hopkins, BA Gomez, TM AF Behravesh, Casey Barton Brinson, Denise Hopkins, Brett A. Gomez, Thomas M. TI Backyard Poultry Flocks and Salmonellosis: A Recurring, Yet Preventable Public Health Challenge SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE Salmonella; zoonoses; outbreak; backyard poultry; mail-order hatchery ID MAIL-ORDER HATCHERY; UNITED-STATES; MULTISTATE OUTBREAK; LIVE POULTRY; CONTACT; SURVEILLANCE; TYPHIMURIUM; MANAGEMENT; PATHOGENS; CHILDREN AB Poultry are well recognized as possible carriers of Salmonella species. As part of the local foods movement, backyard poultry flocks have increased in popularity in recent years. Between 1996 and 2012, 45 outbreaks of human Salmonella infections linked to live poultry from mail-order hatcheries were documented. This review examines the history of live poultry-associated salmonellosis in humans in the United States, the current status of the issue, and what can be done to help prevent these illnesses. An integrated One Health approach involving the mail-order hatchery industry, feed stores, healthcare providers, veterinarians, and backyard flock owners is needed to help prevent live poultry-associated salmonellosis. C1 [Behravesh, Casey Barton] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging Zoonot & Infect Dis, Atlanta, GA 30329 USA. [Brinson, Denise] USDA, Natl Poultry Improvement Plan, Conyers, GA USA. [Hopkins, Brett A.] Int Tech Anim Prod & Proc Solut, Overland Pk, KS USA. [Gomez, Thomas M.] USDA, Vet Serv, Anim & Plant Hlth Inspect Serv, Atlanta, GA USA. RP Behravesh, CB (reprint author), Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, 1600 Clifton Rd NE,MS A38, Atlanta, GA 30329 USA. EM cbartonbehravesh@cdc.gov FU Centers for Disease Control and Prevention FX This work was supported by the Centers for Disease Control and Prevention. NR 34 TC 18 Z9 19 U1 2 U2 17 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAY 15 PY 2014 VL 58 IS 10 BP 1432 EP 1438 DI 10.1093/cid/ciu067 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AH3RZ UT WOS:000336044200018 PM 24501387 ER PT J AU Kuniholm, MH Jung, M Everhart, JE Cotler, S Heiss, G McQuillan, G Kim, RS Strickler, HD Thyagarajan, B Youngblood, M Kaplan, RC Ho, GYF AF Kuniholm, Mark H. Jung, Molly Everhart, James E. Cotler, Scott Heiss, Gerardo McQuillan, Geraldine Kim, Ryung S. Strickler, Howard D. Thyagarajan, Bharat Youngblood, Marston Kaplan, Robert C. Ho, Gloria Y. F. TI Prevalence of Hepatitis C Virus Infection in US Hispanic/Latino Adults: Results From the NHANES 2007-2010 and HCHS/SOL Studies SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE hepatitis C virus; HCV; Hispanic; Latino; United States; prevalence; antibody; RNA; risk factor ID UNITED-STATES; LATINOS; DESIGN AB Prevalence of hepatitis C virus (HCV) antibody has been reported in Mexican Americans, but its prevalence in other US Hispanic/Latino groups is unknown. We studied 2 populations of US Hispanic/Latino adults; 3210 from the National Health and Nutrition Examination Survey (NHANES) 2007-2010 and 11 964 from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Age-standardized prevalence of HCV antibody was similar in NHANES 2007-2010 (1.5%) and HCHS/SOL (2.0%) but differed significantly by Hispanic/Latino background in HCHS/SOL (eg, 11.6% in Puerto Rican men vs 0.4% in South American men). These findings suggest that the HCV epidemic among US Hispanics/Latinos is heterogeneous. C1 [Kuniholm, Mark H.; Jung, Molly; Kim, Ryung S.; Strickler, Howard D.; Kaplan, Robert C.; Ho, Gloria Y. F.] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10461 USA. [Everhart, James E.] NIDDK, Epidemiol & Data Syst Program, Div Digest Dis & Nutr, Bethesda, MD 20892 USA. [Cotler, Scott] Loyola Univ, Med Ctr, Dept Med, Div Hepatol, Maywood, IL 60153 USA. [Heiss, Gerardo; Youngblood, Marston] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA. [McQuillan, Geraldine] Ctr Dis Control & Prevent, Div Hlth & Nutr Examinat Surveys, Hyattsville, MD USA. [Thyagarajan, Bharat] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA. RP Kuniholm, MH (reprint author), Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Belfer Bldg,Rm 1308C,1300 Morris Pk Ave, Bronx, NY 10461 USA. EM mark.kuniholm@einstein.yu.edu FU National Heart, Lung, and Blood Institute (NHLBI) [N01-HC65233]; University of Miami [N01-HC65234]; Albert Einstein College of Medicine [N01-HC65235]; Northwestern University [N01-HC65236]; San Diego State University [N01-HC65237]; National Center for Advancing Translational Sciences (NCATS), through CTSA [UL1RR025750, KL2RR025749] FX The Hispanic Community Health Study/Study of Latinos was carried out as a collaborative study supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236), and San Diego State University (N01-HC65237). The following Institutes/Centers/Offices contribute to the HCHS/SOL through a transfer of funds to the NHLBI: National Institute on Minority Health and Health Disparities, National Institute on Deafness and Other Communication Disorders, National Institute of Dental and Craniofacial Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, NIH Institution-Office of Dietary Supplements. M. H. K. is supported in part by the National Center for Advancing Translational Sciences (NCATS), through CTSA grants UL1RR025750 and KL2RR025749. NR 8 TC 14 Z9 14 U1 2 U2 5 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD MAY 15 PY 2014 VL 209 IS 10 BP 1585 EP 1590 DI 10.1093/infdis/jit672 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AH4CJ UT WOS:000336073000012 PM 24423693 ER PT J AU Wright, PF Wieland-Alter, W Ilyushina, NA Hoen, AG Arita, M Boesch, AW Ackerman, ME van der Avoort, H Oberste, MS Pallansch, MA Burton, AH Jaffar, MA Sutter, RW AF Wright, Peter F. Wieland-Alter, Wendy Ilyushina, Natalia A. Hoen, Anne G. Arita, Minetaro Boesch, Austin W. Ackerman, Margaret E. van der Avoort, Harrie Oberste, M. Steven Pallansch, Mark A. Burton, Anthony H. Jaffar, Mohammad A. Sutter, Roland W. TI Intestinal Immunity Is a Determinant of Clearance of Poliovirus After Oral Vaccination SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE polio; vaccine; IgA; mucosal immunity ID IMMUNIZATION SCHEDULES; MUCOSAL IMMUNITY; INFECTION; POLIOVACCINE; CIRCULATION; SECRETIONS; CHILDREN; ANTIBODY; INFANTS; SERUM AB Background. Response to challenge with live, attenuated, oral polio vaccine (OPV) is a measure of immunity induced by prior immunization. Methods. Using stool samples from a study from Oman in which an initial schedule of inactivated polio vaccine (IPV) was followed by an OPV type 1 challenge, we quantitated virus shed, sequenced capsid proteins of recovered virus, and developed assays for neutralization of poliovirus and mucosal immunoglobulin A (IgA) detection. Results. Neutralizing activity correlated with detection of polio-specific IgA in stool suspensions collected 7 days after OPV type 1 challenge. Both neutralization and IgA in stool were associated with cessation of virus shedding by day 7. Rapid development of an IgA response with cessation of shedding suggests that IPV primed for the early response to challenge. Correlation of neutralization activity and IgA detection provides evidence that polio-specific IgA intestinal antibody is a determinant of mucosal shedding/transmission and that IgA functions through neutralization of virus. In contrast, neither presence nor quantity of serum or intestinal antibody induced by IPV prior to challenge correlated with cessation of shedding. Conclusions. These assays provide an opportunity to study other immunization schedules to gain a broader understanding of the appearance and duration of a protective mucosal response to polio vaccination. C1 [Wright, Peter F.; Wieland-Alter, Wendy; Ilyushina, Natalia A.] Geisel Med Sch Dartmouth, Div Infect Dis & Int Med, Lebanon, NH 03756 USA. [Hoen, Anne G.] Geisel Med Sch Dartmouth, Dept Community & Family Med, Sect Biostat & Epidemiol, Lebanon, NH 03756 USA. [Arita, Minetaro] Natl Inst Infect Dis, Tokyo, Japan. [Boesch, Austin W.; Ackerman, Margaret E.] Thayer Sch Engn Dartmouth, Hanover, NH USA. [van der Avoort, Harrie] Ctr Infect Dis Res, RIVM IDS, Bilthoven, Netherlands. [Oberste, M. Steven; Pallansch, Mark A.] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA. [Burton, Anthony H.] WHO, CH-1211 Geneva, Switzerland. [Sutter, Roland W.] WHO, Global Polio Eradicat Initiat, CH-1211 Geneva, Switzerland. RP Wright, PF (reprint author), Geisel Med Sch Dartmouth, Dept Pediat, 1 Med Ctr Dr,Borwell 330 W, Lebanon, NH 03756 USA. EM peter.f.wright@hitchcock.org OI arita, minetaro/0000-0002-3314-6626 FU Bill & Melinda Gates Foundation [OPP1039141, OPP1032817] FX This work was supported by the Bill & Melinda Gates Foundation Grand Challenges Exploration Grant (grant number OPP1039141 to P. F. W.) and also from the Bill and Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery Grant (grant number OPP1032817 to M. E. A.). NR 26 TC 8 Z9 8 U1 4 U2 8 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD MAY 15 PY 2014 VL 209 IS 10 BP 1628 EP 1634 DI 10.1093/infdis/jit671 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AH4CJ UT WOS:000336073000018 PM 24459191 ER PT J AU Kelley, EJ Driebe, EM Etienne, K Brandt, ME Schupp, JM Gillece, JD Trujillo, JS Lockhart, SR Deak, E Keim, PS Engelthaler, DM AF Kelley, Erin J. Driebe, Elizabeth M. Etienne, Kizee Brandt, Mary E. Schupp, James M. Gillece, John D. Trujillo, Jesse S. Lockhart, Shawn R. Deak, Eszter Keim, Paul S. Engelthaler, David M. TI Real-time PCR assays for genotyping of Cryptococcus gattii in North America SO BMC MICROBIOLOGY LA English DT Article DE Cryptococcus gattii; Genotyping; Real-time PCR; Epidemiology ID VANCOUVER-ISLAND; BRITISH-COLUMBIA; NEOFORMANS; OUTBREAK; SUSCEPTIBILITIES; STRAINS AB Background: Cryptococcus gattii has been the cause of an ongoing outbreak starting in 1999 on Vancouver Island, British Columbia and spreading to mainland Canada and the US Pacific Northwest. In the course of the outbreak, C. gattii has been identified outside of its previously documented climate, habitat, and host disease. Genotyping of C. gattii is essential to understand the ecological and geographical expansion of this emerging pathogen. Methods: We developed and validated a mismatch amplification mutation assay (MAMA) real-time PCR panel for genotyping C. gattii molecular types VGI-VGIV and VGII subtypes a,b,c. Subtype assays were designed based on whole-genome sequence of 20 C. gattii strains. Publically available multilocus sequence typing (MLST) data from a study of 202 strains was used for the molecular type (VGI-VGIV) assay design. All assays were validated across DNA from 112 strains of diverse international origin and sample types, including animal, environmental and human. Results: Validation revealed each assay on the panel is 100% sensitive, specific and concordant with MLST. The assay panel can detect down to 0.5 picograms of template DNA. Conclusions: The (MAMA) real-time PCR panel for C. gattii accurately typed a collection of 112 diverse strains and demonstrated high sensitivity. This is a time and cost efficient method of genotyping C. gattii best suited for application in large-scale epidemiological studies. C1 [Kelley, Erin J.; Driebe, Elizabeth M.; Schupp, James M.; Gillece, John D.; Trujillo, Jesse S.; Keim, Paul S.; Engelthaler, David M.] Translat Genom Res Inst, Flagstaff, AZ 86001 USA. [Etienne, Kizee; Brandt, Mary E.; Lockhart, Shawn R.; Deak, Eszter] Ctr Dis Control & Prevent, Atlanta, GA USA. [Deak, Eszter] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA. [Keim, Paul S.] No Arizona Univ, Ctr Microbial Genet & Genom, Flagstaff, AZ 86011 USA. RP Kelley, EJ (reprint author), Translat Genom Res Inst, 3051 W Shamrell Blvd Ste 106, Flagstaff, AZ 86001 USA. EM ekelley@tgen.org FU National Institutes of Health [R21AI098059] FX The authors wish to thank the members of the Cryptococcus gattii Public Health Working Group for submission of many of the isolates used in this study. This work was supported by funds from the National Institutes of Health: R21AI098059. NR 23 TC 0 Z9 0 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2180 J9 BMC MICROBIOL JI BMC Microbiol. PD MAY 13 PY 2014 VL 14 AR 125 DI 10.1186/1471-2180-14-125 PG 15 WC Microbiology SC Microbiology GA AI2HD UT WOS:000336677400001 PM 24886039 ER PT J AU Noronha, AS Markowitz, LE Dunne, EF AF Noronha, Alinea S. Markowitz, Lauri E. Dunne, Eileen F. TI Systematic review of human papillomavirus vaccine coadministration SO VACCINE LA English DT Review DE Coadministration; Concomitant; HPV vaccination; Immunogenicity; Safety ID CERVICAL-CANCER VACCINE; MENINGOCOCCAL GLYCOCONJUGATE VACCINE; ACELLULAR PERTUSSIS-VACCINE; HEPATITIS-B-VACCINE; AS04-ADJUVANTED VACCINE; RANDOMIZED-TRIAL; REDUCED DIPHTHERIA; HEALTHY GIRLS; MENACWY-CRM; IMMUNOGENICITY AB Human papillomavirus (HPV) vaccination is recommended in early adolescence, at an age when other vaccines are also recommended. Administration of multiple vaccines during one visit is an opportunity to improve uptake of adolescent vaccines. We conducted a systematic review of safety and immunogenicity of HPV vaccines coadministered with other vaccines. Our review included 9 studies, 4 of quadrivalent HPV vaccine and 5 of bivalent HPV vaccine; coadministered vaccines included: meningococcal conjugate, hepatitis A, hepatitis B, combined hepatitis A and B, tetanus, diphtheria, acellular pertussis, and inactivated poliovirus vaccines. Studies varied in methods of data collection and measurement of immunogenicity and safety. Noninferiority of immune response and an acceptable safety profile were demonstrated when HPV vaccine was coadministered with other vaccines. Published by Elsevier Ltd. C1 [Noronha, Alinea S.; Markowitz, Lauri E.; Dunne, Eileen F.] Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. RP Dunne, EF (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,MS E-02, Atlanta, GA 30333 USA. EM dde9@cdc.gov NR 19 TC 19 Z9 19 U1 1 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD MAY 13 PY 2014 VL 32 IS 23 BP 2670 EP 2674 DI 10.1016/j.vaccine.2013.12.037 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AI3QG UT WOS:000336776400003 PM 24412351 ER PT J AU Young, HS Dirzo, R Helgen, KM McCauley, DJ Billeter, SA Kosoy, MY Osikowicz, LM Salkeld, DJ Young, TP Dittmar, K AF Young, Hillary S. Dirzo, Rodolfo Helgen, Kristofer M. McCauley, Douglas J. Billeter, Sarah A. Kosoy, Michael Y. Osikowicz, Lynn M. Salkeld, Daniel J. Young, Truman P. Dittmar, Katharina TI Declines in large wildlife increase landscape-level prevalence of rodent-borne disease in Africa SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE Kenya; dilution effect ID INFECTIOUS-DISEASE; SMALL MAMMALS; LYME-DISEASE; SPECIES-DIVERSITY; COMMUNITY COMPOSITION; FLEAS SIPHONAPTERA; LARGE HERBIVORES; EXTINCTION RISK; BARTONELLA SPP.; HOST DIVERSITY AB Populations of large wildlife are declining on local and global scales. The impacts of this pulse of size-selective defaunation include cascading changes to smaller animals, particularly rodents, and alteration of many ecosystem processes and services, potentially involving changes to prevalence and transmission of zoonotic disease. Understanding linkages between biodiversity loss and zoonotic disease is important for both public health and nature conservation programs, and has been a source of much recent scientific debate. In the case of rodent-borne zoonoses, there is strong conceptual support, but limited empirical evidence, for the hypothesis that defaunation, the loss of large wildlife, increases zoonotic disease risk by directly or indirectly releasing controls on rodent density. We tested this hypothesis by experimentally excluding large wildlife from a savanna ecosystem in East Africa, and examining changes in prevalence and abundance of Bartonella spp. infection in rodents and their flea vectors. We found no effect of wildlife removal on per capita prevalence of Bartonella infection in either rodents or fleas. However, because rodent and, consequently, flea abundance doubled following experimental defaunation, the density of infected hosts and infected fleas was roughly twofold higher in sites where large wildlife was absent. Thus, defaunation represents an elevated risk in Bartonella transmission to humans (bartonellosis). Our results (i) provide experimental evidence of large wildlife defaunation increasing landscape-level disease prevalence, (ii) highlight the importance of susceptible host regulation pathways and host/vector density responses in biodiversity-disease relationships, and (iii) suggest that rodent-borne disease responses to large wildlife loss may represent an important context where this relationship is largely negative. C1 [Young, Hillary S.; McCauley, Douglas J.] Univ Calif Santa Barbara, Dept Ecol Evolut & Marine Biol, Santa Barbara, CA 93106 USA. [Young, Hillary S.; Dirzo, Rodolfo; McCauley, Douglas J.] Stanford Univ, Dept Biol, Stanford, CA 94305 USA. [Salkeld, Daniel J.] Stanford Univ, Woods Inst Environm, Stanford, CA 94305 USA. [Young, Hillary S.; Helgen, Kristofer M.] Smithsonian Inst, Natl Museum Nat Hist, Div Mammals, Washington, DC 20013 USA. [Billeter, Sarah A.; Kosoy, Michael Y.; Osikowicz, Lynn M.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Natl Ctr Infect Dis, Ft Collins, CO 80521 USA. [Salkeld, Daniel J.] Colorado State Univ, Dept Biol, Ft Collins, CO 80523 USA. [Young, Truman P.] Univ Calif Davis, Dept Plant Sci, Davis, CA 95616 USA. [Dittmar, Katharina] SUNY Buffalo, Dept Biol Sci, Buffalo, NY 14260 USA. RP Dirzo, R (reprint author), Stanford Univ, Dept Biol, Stanford, CA 94305 USA. EM rdirzo@stanford.edu FU James Smithson Fund of the Smithsonian Institution; National Geographic Society; National Science Foundation [BSR-97-07477, 03-16402, 08-16453, 12-56034, DEB-09-09670, DEB-1213740]; Natural Sciences and Engineering Council of Canada; African Elephant Program of the US Fish and Wildlife Service [98210-0-G563]; Woods Institute for the Environment; Smithsonian Institution Women's Committee FX We thank Cara Brook, Ralph Eckerlin, Jackson Ekadeli, Frederick Erii, Lauren Gillespie, Lauren Helgen, Ashley Hintz, Helen Kafka, Felicia Keesing, John Lochikuya, Margaret Kinnaird, Peter Lokeny, Darrin Lunde, Scott Miller, Mathew Namoni, Everlyn Ndinda, John Ososky, John Montenieri, Jack Silange, Michael Hastriter, and Michael Whiting for help in this project. Financial support for this project came from the James Smithson Fund of the Smithsonian Institution, the National Geographic Society, the National Science Foundation (Long Term Research in Environmental Biology Grants BSR-97-07477, 03-16402, 08-16453, 12-56034, DEB-09-09670, and DEB-1213740), the Natural Sciences and Engineering Council of Canada, the African Elephant Program of the US Fish and Wildlife Service (Grant 98210-0-G563), the Woods Institute for the Environment, and the Smithsonian Institution Women's Committee. Vector images were provided courtesy of the Integration and Application Network, University of Maryland Center for Environmental Science (http://ian.umces.edu/imagelibrary). NR 68 TC 25 Z9 26 U1 12 U2 132 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD MAY 13 PY 2014 VL 111 IS 19 BP 7036 EP 7041 DI 10.1073/pnas.1404958111 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AH0GS UT WOS:000335798000068 PM 24778215 ER PT J AU deCastro, BR AF deCastro, B. Rey TI Acrolein and Asthma Attack Prevalence in a Representative Sample of the United States Adult Population 2000-2009 SO PLOS ONE LA English DT Article ID HAZARDOUS AIR-POLLUTANTS; AUTISM SPECTRUM DISORDERS; HEALTH INTERVIEW SURVEY; TOXICS CONCENTRATIONS; OXIDATIVE STRESS; INHALED ACROLEIN; RISK-ASSESSMENT; LUNG-FUNCTION; MAIN ROAD; POLLUTION AB Background: Acrolein is an air toxic and highly potent respiratory irritant. There is little epidemiology available, but US EPA estimates that outdoor acrolein is responsible for about 75 percent of non-cancer respiratory health effects attributable to air toxics in the United States, based on the Agency's 2005 NATA (National-Scale Air Toxics Assessment) and acrolein's comparatively potent inhalation reference concentration of 0.02 mu g/m(3). Objectives: Assess the association between estimated outdoor acrolein exposure and asthma attack reported by a representative cross-sectional sample of the adult United States population. Methods: NATA 2005 chronic outdoor acrolein exposure estimates at the census tract were linked with residences oif adults (>= 18 years old) in the NHIS (National Health Interview Survey) 2000 - 2009 (n = 271,348 subjects). A sample-weighted logistic regression model characterized the association between the prevalence of reporting at least one asthma attack in the 12 months prior to survey interview and quintiles of exposure to outdoor acrolein, controlling for potential confounders. Results: In the highest quintile of outdoor acrolein exposure (0.05 - 0.46 mu g/m(3)), there was a marginally significant increase in the asthma attack pOR (prevalence-odds ratio [95% CI] = 1.08 [0.98: 1.19]) relative to the lowest quintile. The highest quintile was also associated with a marginally significant increase in prevalence-odds (1.13 [0.98: 1.29]) in a model limited to never smokers (n = 153,820). Conclusions: Chronic exposure to outdoor acrolein of 0.05 - 0.46 mg/m(3) appears to increase the prevalence-odds of having at least one asthma attack in the previous year by 8 percent in a representative cross-sectional sample of the adult United States population. C1 Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30333 USA. RP deCastro, BR (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30333 USA. EM rdecastro@cdc.gov RI deCastro, Rey/G-2874-2011 OI deCastro, Rey/0000-0002-1610-5849 NR 96 TC 6 Z9 6 U1 1 U2 17 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 9 PY 2014 VL 9 IS 5 AR e96926 DI 10.1371/journal.pone.0096926 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AI4LX UT WOS:000336838000080 PM 24816802 ER PT J AU Thomson, R Festo, C Johanes, B Kalolella, A Bruxvoort, K Nchimbi, H Tougher, S Cairns, M Taylor, M Kleinschmidt, I Ye, Y Mann, A Ren, RL Willey, B Arnold, F Hanson, K Kachur, SP Goodman, C AF Thomson, Rebecca Festo, Charles Johanes, Boniface Kalolella, Admirabilis Bruxvoort, Katia Nchimbi, Happy Tougher, Sarah Cairns, Matthew Taylor, Mark Kleinschmidt, Immo Ye, Yazoume Mann, Andrea Ren, Ruilin Willey, Barbara Arnold, Fred Hanson, Kara Kachur, S. Patrick Goodman, Catherine TI Has Tanzania Embraced the Green Leaf? Results from Outlet and Household Surveys before and after Implementation of the Affordable Medicines Facility - Malaria SO PLOS ONE LA English DT Article ID RAPID DIAGNOSTIC-TESTS; COMBINATION THERAPIES; MARKET SHARE; 7 COUNTRIES; AVAILABILITY; REGIONS; IMPACT; PRICE; AMFM; ACT AB Background: The Affordable Medicines Facility - malaria (AMFm) is primarily an artemisinin combination therapy (ACT) subsidy, aimed at increasing availability, affordability, market share and use of quality-assured ACTs (QAACTs). Mainland Tanzania was one of eight national scale programmes where AMFm was introduced in 2010. Here we present findings from outlet and household surveys before and after AMFm implementation to evaluate its impact from both the supply and demand side. Methods: Outlet surveys were conducted in 49 randomly selected wards throughout mainland Tanzania in 2010 and 2011, and data on outlet characteristics and stocking patterns were collected from outlets stocking antimalarials. Household surveys were conducted in 240 randomly selected enumeration areas in three regions in 2010 and 2012. Questions about treatment seeking for fever and drugs obtained were asked of individuals reporting fever in the previous two weeks. Results: The availability of QAACTs increased from 25.5% to 69.5% among all outlet types, with the greatest increase among pharmacies and drug stores, together termed specialised drug sellers (SDSs), where the median QAACT price fell from $5.63 to $0.94. The market share of QAACTs increased from 26.2% to 42.2%, again with the greatest increase in SDSs. Household survey results showed a shift in treatment seeking away from the public sector towards SDSs. Overall, there was no change in the proportion of people with fever obtaining an antimalarial or ACT from baseline to endline. However, when broken down by treatment source, ACT use increased significantly among clients visiting SDSs. Discussion: Unchanged ACT use overall, despite increases in QAACT availability, affordability and market share in the private sector, reflected a shift in treatment seeking towards private providers. The reasons for this shift are unclear, but likely reflect both persistent stockouts in public facilities, and the increased availability of subsidised ACTs in the private sector. C1 [Thomson, Rebecca; Bruxvoort, Katia; Tougher, Sarah; Cairns, Matthew; Taylor, Mark; Kleinschmidt, Immo; Mann, Andrea; Willey, Barbara; Hanson, Kara; Goodman, Catherine] London Sch Hyg & Trop Med, London WC1, England. [Thomson, Rebecca; Festo, Charles; Johanes, Boniface; Kalolella, Admirabilis; Bruxvoort, Katia; Nchimbi, Happy] Ifakara Hlth Inst, Dar Es Salaam, Tanzania. [Taylor, Mark] Trnava Univ, Dept Publ Hlth, Trnava, Slovakia. [Ye, Yazoume; Ren, Ruilin; Arnold, Fred] ICF Int, Int Hlth Div, Calverton, MD USA. [Kachur, S. Patrick] Ctr Dis Control & Prevent, Malaria Branch, Atlanta, GA USA. RP Thomson, R (reprint author), London Sch Hyg & Trop Med, London WC1, England. EM Rebecca.thomson@lshtm.ac.uk OI Taylor, Mark/0000-0002-7646-7905 FU Bill and Melinda Gates Foundation through ACT Consortium [PHGB VG0410]; Global Fund to Fight AIDS, Tuberculosis and Malaria FX The study was funded by the Bill and Melinda Gates Foundation (www.gatesfoundation.org), through a grant with the ACT Consortium (actconsortium.org), project code PHGB VG0410. The Independent Evaluation of AMFm was funded by the Global Fund to Fight AIDS, Tuberculosis and Malaria. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 30 TC 5 Z9 5 U1 1 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 9 PY 2014 VL 9 IS 5 AR e95607 DI 10.1371/journal.pone.0095607 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AI4LX UT WOS:000336838000016 PM 24816649 ER PT J AU Johnson, LEA Clara, W Gambhir, M Chacon-Fuentes, R Marin-Correa, C Jara, J Minaya, P Rodriguez, D Blanco, N Iihoshi, N Orozco, M Lange, C Perez, SV Amador, N Widdowson, MA Moen, AC Azziz-Baumgartner, E AF Johnson, Lucinda E. A. Clara, Wilfrido Gambhir, Manoj Chacon-Fuentes, Rafael Marin-Correa, Carlos Jara, Jorge Minaya, Percy Rodriguez, David Blanco, Natalia Iihoshi, Naomi Orozco, Maribel Lange, Carmen Vinicio Perez, Sergio Amador, Nydia Widdowson, Marc-Alain Moen, Ann C. Azziz-Baumgartner, Eduardo TI Improvements in pandemic preparedness in 8 Central American countries, 2008-2012 SO BMC HEALTH SERVICES RESEARCH LA English DT Article DE Pandemic; Influenza; Preparedness; IHR; Central America; Capacity-building; Technical assistance ID INFLUENZA PREPAREDNESS; CHALLENGE; MORTALITY; REGION; PLANS AB Background: In view of ongoing pandemic threats such as the recent human cases of novel avian influenza A (H7N9) in China, it is important that all countries continue their preparedness efforts. Since 2006, Central American countries have received donor funding and technical assistance from the U. S. Centers for Disease Control and Prevention (CDC) to build and improve their capacity for influenza surveillance and pandemic preparedness. Our objective was to measure changes in pandemic preparedness in this region, and explore factors associated with these changes, using evaluations conducted between 2008 and 2012. Methods: Eight Central American countries scored their pandemic preparedness across 12 capabilities in 2008, 2010 and 2012, using a standardized tool developed by CDC. Scores were calculated by country and capability and compared between evaluation years using the Student's t-test and Wilcoxon Rank Sum test, respectively. Virological data reported to WHO were used to assess changes in testing capacity between evaluation years. Linear regression was used to examine associations between scores, donor funding, technical assistance and WHO reporting. Results: All countries improved their pandemic preparedness between 2008 and 2012 and seven made statistically significant gains (p < 0.05). Increases in median scores were observed for all 12 capabilities over the same period and were statistically significant for eight of these (p < 0.05): country planning, communications, routine influenza surveillance, national respiratory disease surveillance, outbreak response, resources for containment, community interventions and health sector response. We found a positive association between preparedness scores and cumulative funding between 2006 and 2011 (R-2 = 0.5, p < 0.01). The number of specimens reported to WHO from participating countries increased significantly from 5,551 (2008) to 18,172 (2012) (p < 0.01). Conclusions: Central America has made significant improvements in influenza pandemic preparedness between 2008 and 2012. U. S. donor funding and technical assistance provided to the region is likely to have contributed to the improvements we observed, although information on other sources of funding and support was unavailable to study. Gains are also likely the result of countries' response to the 2009 influenza pandemic. Further research is required to determine the degree to which pandemic improvements are sustainable. C1 [Johnson, Lucinda E. A.; Widdowson, Marc-Alain; Moen, Ann C.; Azziz-Baumgartner, Eduardo] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Clara, Wilfrido] Ctr Dis Control & Prevent, Influenza Program, Reg Off Cent Amer, San Salvador, El Salvador. [Gambhir, Manoj] Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia. [Chacon-Fuentes, Rafael; Jara, Jorge; Blanco, Natalia] Univ Valle Guatemala, Ctr Hlth Studies, Guatemala City, Guatemala. [Marin-Correa, Carlos; Minaya, Percy] Training Epidemiol & Publ Hlth Intervent Network, Atlanta, GA USA. [Rodriguez, David] Minist Hlth El Salvador, Gen Directorate Hlth Surveillance, San Salvador, El Salvador. [Iihoshi, Naomi; Vinicio Perez, Sergio] Minist Hlth Guatemala, Natl Epidemiol Ctr, Guatemala City, Guatemala. [Orozco, Maribel] Council Ministers Hlth Cent Amer & Dominican Rep, San Salvador, El Salvador. [Lange, Carmen] Minist Hlth Panama, Dept Epidemiol, Panama City, Panama. [Amador, Nydia] Minist Hlth Costa Rica, Gen Directorate Hlth Surveillance, San Jose, Costa Rica. RP Azziz-Baumgartner, E (reprint author), Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM eha9@cdc.gov NR 13 TC 4 Z9 4 U1 1 U2 8 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1472-6963 J9 BMC HEALTH SERV RES JI BMC Health Serv. Res. PD MAY 9 PY 2014 VL 14 AR 209 DI 10.1186/1472-6963-14-209 PG 9 WC Health Care Sciences & Services SC Health Care Sciences & Services GA AH3WE UT WOS:000336056100001 PM 24886275 ER PT J AU Mitruka, K Thornton, K Cusick, S Orme, C Moore, A Manch, RA Box, T Carroll, C Holtzman, D Ward, JW AF Mitruka, Kiren Thornton, Karla Cusick, Susanne Orme, Christina Moore, Ann Manch, Richard A. Box, Terry Carroll, Christie Holtzman, Deborah Ward, John W. TI Expanding Primary Care Capacity to Treat Hepatitis C Virus Infection Through an Evidence-Based Care Model - Arizona and Utah, 2012-2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID UNITED-STATES; BARRIERS; OUTCOMES C1 [Mitruka, Kiren; Holtzman, Deborah; Ward, John W.] CDC, Div Viral Hepatitis, Natl Ctr Natl Ctr HIV AIDS Viral Hepatitis STD &, Phoenix, AZ 85027 USA. [Thornton, Karla; Carroll, Christie] Univ New Mexico, Hlth Sci Ctr, Phoenix, AZ USA. [Cusick, Susanne; Orme, Christina; Box, Terry] Univ Utah, Sch Med, Phoenix, AZ USA. [Moore, Ann; Manch, Richard A.] St Josephs Hosp, Phoenix, AZ USA. RP Mitruka, K (reprint author), CDC, Div Viral Hepatitis, Natl Ctr Natl Ctr HIV AIDS Viral Hepatitis STD &, Phoenix, AZ 85027 USA. EM kmitruka@cdc.gov NR 10 TC 18 Z9 18 U1 0 U2 2 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAY 9 PY 2014 VL 63 IS 18 BP 393 EP 398 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AG6GM UT WOS:000335517100001 PM 24807237 ER PT J AU Beckett, GA Ramirez, G Vanderhoff, A Nichols, K Chute, SM Wyles, DL Schoenbachler, BT Bedell, DT Cabral, R Ward, JW AF Beckett, Geoff A. Ramirez, Gilberto Vanderhoff, Aaron Nichols, Kim Chute, Sara M. Wyles, David L. Schoenbachler, Ben T. Bedell, Deborah T. Cabral, Rebecca Ward, John W. TI Early Identification and Linkage to Care of Persons with Chronic Hepatitis B Virus Infection - Three US Sites, 2012-2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article AB In the United States, an estimated 0.8-1.4 million persons are living with chronic hepatitis B virus (HBV) infection. Among these persons, as many as 70% were born in countries of Asia, Africa, or other regions where HBV is moderately or highly endemic (hepatitis B surface antigen [HBsAg] prevalence >= 2%) (1). HBV-associated cirrhosis and liver cancer are major health problems for these populations (2,3). Most persons with HBV were infected at birth or during early childhood and are asymptomatic until advanced liver disease develops. To address these concerns, CDC recommends HBsAg testing for all persons born in these areas and linkage to medical care and preventive services for those who are infected (1). In 2012, CDC awarded funds to nine sites to implement this recommendation. This report describes programs at three sites (New York, New York; Minneapolis-St. Paul, Minnesota; and San Diego, California) that conducted HBV testing, in clinical or community settings, and referred for medical evaluation and care those persons whose HBsAg test results were positive. During October 2012-March 2014, the three sites tested 4,727 persons for HBV infection; 310 (6.6%) were HBsAg-positive. Among the HBsAg-positive persons, 94% were informed of their results, 90% were counseled, 86% were referred for care, and 66% attended their scheduled first medical visit. These projects demonstrate that community-based programs can identify infected persons among populations with a high prevalence of HBV infection and refer HBsAg-positive persons for care. Individualized efforts to assist patients with accessing and receiving health-care services ("patient navigation services") can increase the number of persons who follow up on referrals and receive recommended care. C1 [Beckett, Geoff A.; Ramirez, Gilberto; Schoenbachler, Ben T.; Bedell, Deborah T.; Cabral, Rebecca; Ward, John W.] CDC, Div Viral Hepatitis, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Chute, Sara M.] Minnesota Dept Hlth, Minneapolis, MN 55414 USA. [Wyles, David L.] Univ Calif San Diego, San Diego, CA 92103 USA. RP Beckett, GA (reprint author), CDC, Div Viral Hepatitis, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. EM gbeckett@cdc.gov NR 5 TC 9 Z9 9 U1 1 U2 4 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAY 9 PY 2014 VL 63 IS 18 BP 399 EP 401 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AG6GM UT WOS:000335517100002 PM 24807238 ER PT J AU Patton, ME Su, JR Nelson, R Weinstock, H AF Patton, Monica E. Su, John R. Nelson, Robert Weinstock, Hillard TI Primary and Secondary Syphilis - United States, 2005-2013 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID CARE; MEN; SEX C1 [Patton, Monica E.] CDC, Atlanta, GA 30333 USA. [Su, John R.; Nelson, Robert; Weinstock, Hillard] CDC, Div Sexually Transmitted Dis Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. RP Patton, ME (reprint author), CDC, Atlanta, GA 30333 USA. EM mepatton@cdc.gov NR 10 TC 70 Z9 71 U1 0 U2 5 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAY 9 PY 2014 VL 63 IS 18 BP 402 EP 406 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AG6GM UT WOS:000335517100003 PM 24807239 ER PT J AU Carroll, DD Courtney-Long, EA Stevens, AC Sloan, ML Lullo, C Visser, SN Fox, MH Armour, BS Campbell, VA Brown, DR Dorn, JM AF Carroll, Dianna D. Courtney-Long, Elizabeth A. Stevens, Alissa C. Sloan, Michelle L. Lullo, Carolyn Visser, Susanna N. Fox, Michael H. Armour, Brian S. Campbell, Vincent A. Brown, David R. Dorn, Joan M. TI Vital Signs: Disability and Physical Activity - United States, 2009-2012 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID CARE; BARRIERS; ADULTS AB Background: Adults with disabilities are less active and have higher rates of chronic disease than the general population. Given the health benefits of physical activity, understanding physical activity, its relationship with chronic disease, and health professional recommendations for physical activity among young to middle-age adults with disabilities could help increase the effectiveness of health promotion efforts. Methods: Data from the 2009-2012 National Health Interview Survey (NHIS) were used to estimate the prevalence of, and association between, aerobic physical activity (inactive, insufficiently active, or active) and chronic diseases (heart disease, stroke, diabetes, and cancer) among adults aged 18-64 years by disability status and type (hearing, vision, cognitive, and mobility). The prevalence of, and association between, receiving a health professional recommendation for physical activity and level of aerobic physical activity was assessed using 2010 data. Results: Overall, 11.6% of U.S. adults aged 18-64 years reported a disability, with estimates for disability type ranging from 1.7% (vision) to 5.8% (mobility). Compared with adults without disabilities, inactivity was more prevalent among adults with any disability (47.1% versus 26.1%) and for adults with each type of disability. Inactive adults with disabilities were 50% more likely to report one or more chronic diseases than those who were physically active. Approximately 44% of adults with disabilities received a recommendation from a health professional for physical activity in the past 12 months. Conclusions: Almost half of adults with disabilities are physically inactive and are more likely to have a chronic disease. Among adults with disabilities who visited a health professional in the past 12 months, the majority (56%) did not receive a recommendation for physical activity. Implications for Public Health: These data highlight the need for increased physical activity among persons with disabilities, which might require support across societal sectors, including government and health care. C1 [Carroll, Dianna D.; Courtney-Long, Elizabeth A.; Stevens, Alissa C.; Sloan, Michelle L.; Lullo, Carolyn; Visser, Susanna N.; Fox, Michael H.; Armour, Brian S.; Campbell, Vincent A.] CDC, Div Human Dev & Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Brown, David R.; Dorn, Joan M.] CDC, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. RP Carroll, DD (reprint author), CDC, Div Human Dev & Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. EM ddcarroll@cdc.gov NR 21 TC 24 Z9 24 U1 2 U2 6 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAY 9 PY 2014 VL 63 IS 18 BP 407 EP 413 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AG6GM UT WOS:000335517100004 PM 24807240 ER PT J AU Dabelea, D Mayer-Davis, EJ Saydah, S Imperatore, G Linder, B Divers, J Bell, R Badaru, A Talton, JW Crume, T Liese, AD Merchant, AT Lawrence, JM Reynolds, K Dolan, L Liu, LL Hamman, RF AF Dabelea, Dana Mayer-Davis, Elizabeth J. Saydah, Sharon Imperatore, Giuseppina Linder, Barbara Divers, Jasmin Bell, Ronny Badaru, Angela Talton, Jennifer W. Crume, Tessa Liese, Angela D. Merchant, Anwar T. Lawrence, Jean M. Reynolds, Kristi Dolan, Lawrence Liu, Lenna L. Hamman, Richard F. CA SEARCH Diabet Youth Study TI Prevalence of Type 1 and Type 2 Diabetes Among Children and Adolescents From 2001 to 2009 SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID CHILDHOOD TYPE-1; UNITED-STATES; INCREASING INCIDENCE; RISK-FACTORS; US YOUTH; MELLITUS; SEARCH; POPULATION; OBESITY; COHORT AB IMPORTANCE Despite concern about an "epidemic," there are limited data on trends in prevalence of either type 1 or type 2 diabetes across US race and ethnic groups. OBJECTIVE To estimate changes in the prevalence of type 1 and type 2 diabetes in US youth, by sex, age, and race/ethnicity between 2001 and 2009. DESIGN, SETTING, AND PARTICIPANTS Case patients were ascertained in 4 geographic areas and 1 managed health care plan. The study population was determined by the 2001 and 2009 bridged-race intercensal population estimates for geographic sites and membership counts for the health plan. MAIN OUTCOMES AND MEASURES Prevalence (per 1000) of physician-diagnosed type 1 diabetes in youth aged 0 through 19 years and type 2 diabetes in youth aged 10 through 19 years. RESULTS In 2001, 4958 of 3.3 million youth were diagnosed with type 1 diabetes for a prevalence of 1.48 per 1000 (95% CI, 1.44-1.52). In 2009, 6666 of 3.4 million youth were diagnosed with type 1 diabetes for a prevalence of 1.93 per 1000 (95% CI, 1.88-1.97). In 2009, the highest prevalence of type 1 diabetes was 2.55 per 1000 among white youth (95% CI, 2.48-2.62) and the lowest was 0.35 per 1000 in American Indian youth (95% CI, 0.26-0.47) and type 1 diabetes increased between 2001 and 2009 in all sex, age, and race/ethnic subgroups except for those with the lowest prevalence (age 0-4 years and American Indians). Adjusted for completeness of ascertainment, there was a 21.1% (95% CI, 15.6%-27.0%) increase in type 1 diabetes over 8 years. In 2001, 588 of 1.7 million youth were diagnosed with type 2 diabetes for a prevalence of 0.34 per 1000 (95% CI, 0.31-0.37). In 2009, 819 of 1.8 million were diagnosed with type 2 diabetes for a prevalence of 0.46 per 1000 (95% CI, 0.43-0.49). In 2009, the prevalence of type 2 diabetes was 1.20 per 1000 among American Indian youth (95% CI, 0.96-1.51); 1.06 per 1000 among black youth (95% CI, 0.93-1.22); 0.79 per 1000 among Hispanic youth (95% CI, 0.70-0.88); and 0.17 per 1000 among white youth (95% CI, 0.15-0.20). Significant increases occurred between 2001 and 2009 in both sexes, all age-groups, and in white, Hispanic, and black youth, with no significant changes for Asian Pacific Islanders and American Indians. Adjusted for completeness of ascertainment, there was a 30.5%(95% CI, 17.3%-45.1%) overall increase in type 2 diabetes. CONCLUSIONS AND RELEVANCE Between 2001 and 2009 in 5 areas of the United States, the prevalence of both type 1 and type 2 diabetes among children and adolescents increased. Further studies are required to determine the causes of these increases. C1 [Dabelea, Dana; Crume, Tessa; Hamman, Richard F.] Colorado Sch Publ Hlth, Dept Epidemiol, Aurora, CO 80045 USA. [Mayer-Davis, Elizabeth J.] Univ N Carolina, Dept Nutr, Chapel Hill, NC USA. [Saydah, Sharon; Imperatore, Giuseppina] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA USA. [Linder, Barbara] NIDDK, Childhood Diabet Res Div Diabet Endocrinol & Meta, Bethesda, MD 20892 USA. [Divers, Jasmin; Talton, Jennifer W.] Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC USA. [Bell, Ronny] Wake Forest Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC USA. [Badaru, Angela] Childrens Hosp & Reg Med Ctr, Dept Pediat Endocrinol & Diabet, Seattle, WA USA. [Liese, Angela D.; Merchant, Anwar T.] Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC USA. [Lawrence, Jean M.; Reynolds, Kristi] Kaiser Permanente So Calif, Dept Res & Evaluat, Pasadena, CA 91101 USA. [Dolan, Lawrence] Childrens Hosp Med Ctr, Dept Endocrinol, Cincinnati, OH USA. [Liu, Lenna L.] Univ Washington, Dept Pediat, Seattle, WA 98195 USA. [Liu, Lenna L.] Seattle Childrens Hosp, Seattle, WA USA. RP Dabelea, D (reprint author), Colorado Sch Publ Hlth, Dept Epidemiol, 13001 East 17th Pl,Campus Box B-119, Aurora, CO 80045 USA. EM dana.dabelea@ucdenver.edu FU CDC [PA00097, DP-05-069, DP-10-001]; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); NIDDK; National Institutes of Health (NIH) National Center for Research Resources [UL1RR029882]; NIH [UL1 TR00423]; Clinical and Translational Research Center [UL1 TR000154]; Diabetes and Endocrinology Research Center, NIH [P30 DK57516]; National Center for Research Resources [8 UL1 TR000077]; National Center for Advancing Translational Sciences, NIH; Children with Medical Handicaps program; [U48/CCU919219]; [U01 DP000246]; [U18DP002714]; [U48/CCU819241-3]; [U01 DP000247]; [U18DP000247-06A1]; [U48/CCU519239]; [U01 DP000248]; [1U18DP002709]; [U48/CCU419249]; [U01 DP000254]; [U18DP002708-01]; [U58/CCU019235-4]; [U01 DP000244]; [U18DP002710-01]; [U01 DP000250]; [200-2010-35171] FX SEARCH for Diabetes in Youth is funded by grants PA00097, DP-05-069, and DP-10-001 from the CDC and by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Additional funding was provided to the CDC for these cooperative agreements by the NIDDK. The site contracts grants are U48/CCU919219, U01 DP000246, and U18DP002714 to Kaiser Permanente Southern California; U48/CCU819241-3, U01 DP000247, and U18DP000247-06A1 to the University of Colorado Denver; U48/CCU519239, U01 DP000248, and 1U18DP002709 to the Children's Hospital Medical Center, Cincinnati, Ohio; U48/CCU419249, U01 DP000254, and U18DP002708-01 to the University of North Carolina at Chapel Hill; U58/CCU019235-4, U01 DP000244, and U18DP002710-01 to the University of Washington School of Medicine; U48/CCU919219, U01 DP000250, and 200-2010-35171 to the Wake Forest University School of Medicine. This project was also support by grants UL1RR029882 from the National Institutes of Health (NIH) National Center for Research Resources to the South Carolina Clinical & Translational Research [SCTR] Institute, at the Medical University of South Carolina; UL1 TR00423 from the NIH Clinical and Translational Science Award to the Seattle Children's Hospital of the University of Washington; UL1 TR000154 from the Clinical and Translational Research Center to the University of Colorado Pediatric Clinical; P30 DK57516 from the Diabetes and Endocrinology Research Center, NIH, to the Barbara Davis Center at the University of Colorado at Denver; 8 UL1 TR000077 from the National Center for Research Resources and the National Center for Advancing Translational Sciences, NIH; and the Children with Medical Handicaps program managed by the Ohio Department of Health. NR 43 TC 232 Z9 233 U1 4 U2 62 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAY 7 PY 2014 VL 311 IS 17 BP 1778 EP 1786 DI 10.1001/jama.2014.3201 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA AG4IG UT WOS:000335382300023 PM 24794371 ER PT J AU Lantagne, D Person, B Smith, N Mayer, A Preston, K Blanton, E Jellison, K AF Lantagne, Daniele Person, Bobbie Smith, Natalie Mayer, Ally Preston, Kelsey Blanton, Elizabeth Jellison, Kristen TI Emergency Water Treatment with Bleach in the United States: The Need to Revise EPA Recommendations SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID HOUSEHOLD CHLORINATION; DEVELOPING-COUNTRIES; TURBIDITY AB During emergencies in the United States, the Environmental Protection Agency (EPA) currently recommends using bottled water, or boiling or treating water by adding 1/8 teaspoon (or 8 drops) of bleach to 1 gal of water. This bleach recommendation is internally inconsistent, a relatively high chlorine dose (5.55-8.67 mg/L), and unsupported by evidence. In this study, bleach was added in three different dosages to six waters available to emergency-affected populations in each of six states; free chlorine residual (FCR) and Escherichia coli/total conforms were measured 1-24 h after treatment. Data were analyzed using four efficacy criteria. Results indicated the dosages in the current EPA recommendation are unnecessarily high to ensure (1) maintenance of FCR for 24 h after treatment, (2) absence of E. coli/total conforms, and (3) establishment of a CT-factor sufficient to inactivate Giardia lamblia and enteric viruses 1 h after treatment. Additionally, emergency-prone populations did not have the materials to complete treatment with bleach in their household. Therefore, we recommend EPA review and revise the current recommendation to establish an internally consistent, criteria-based recommendation that is usable by emergency-affected populations. We also recommend investigating the use of, new or commercially available water treatment products for emergency response in the United States. C1 [Lantagne, Daniele; Blanton, Elizabeth] Ctr Dis Control & Prevent, Waterborne Dis Prevent Branch, Atlanta, GA 30333 USA. [Person, Bobbie] Ctr Dis Control & Prevent, Natl Ctr Zoonot & Emerging Infect Dis, Off Director, Atlanta, GA 30333 USA. [Smith, Natalie; Mayer, Ally; Preston, Kelsey; Jellison, Kristen] Lehigh Univ, Dept Civil & Environm Engn, Bethlehem, PA 18015 USA. RP Lantagne, D (reprint author), Tufts Univ, Medford, MA 02155 USA. EM daniele.lantagne@tufts.edu FU Centers for Disease Control and Prevention FX We thank the six households who hosted this study and the Centers for Disease Control and Prevention for funding. Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 34 TC 2 Z9 2 U1 2 U2 15 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD MAY 6 PY 2014 VL 48 IS 9 BP 5093 EP 5100 DI 10.1021/es405357y PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AG9DY UT WOS:000335720100055 PM 24684410 ER PT J AU Santana, WI Williams, TL Winne, EK Pirkle, JL Barr, JR AF Santana, Wanda I. Williams, Tracie L. Winne, Emily K. Pirkle, James L. Barr, John R. TI Quantification of Viral Proteins of the Avian H7 Subtype of Influenza Virus: An Isotope Dilution Mass Spectrometry Method Applicable for Producing more Rapid Vaccines in the Case of an Influenza Pandemic SO ANALYTICAL CHEMISTRY LA English DT Article ID RISK-FACTORS; HONG-KONG; HEMAGGLUTININ; INFECTION; DIGESTION; PEPTIDES; DISEASE; CHINA AB Vaccination is the most effective means to prevent influenza and its serious complications. Influenza viral strains undergo rapid mutations of the surface proteins hemagglutinin (HA) and neuraminidase (NA) requiring vaccines to be frequently updated to include current circulating strains. It is nearly impossible to predict which strains will be circulating in the next influenza season. It is, therefore, imperative that the process of producing a vaccine be streamlined and as swift as possible. We have developed an isotope dilution mass spectrometry (IDMS) method to quantify HA and NA in H7N7, H7N2, and H7N9 influenza. The IDMS method involves enzymatic digestion of viral proteins and the specific detection of evolutionarily conserved target peptides. The four target peptides that were initially chosen for analysis of the HA protein of H7N2 and H7N7 subtypes were conserved and available for analysis of the H7N9 subtype that circulated in China in the spring of 2013. Thus, rapid response to the potential pandemic was realized. Quantification of a protein is performed by employing multiple peptides to ensure that the enzymatic digestion of the protein is efficient in the region of the target peptides, verify the accuracy of the measurement, and provide flexibility in the case of amino acid changes among newly emerging strains. The IDMS method is an accurate, sensitive, and selective method to quantify the amount of HA and NA antigens in primary liquid standards, crude allantoic fluid, purified virus samples, and final vaccine presentations. C1 [Santana, Wanda I.; Williams, Tracie L.; Winne, Emily K.; Pirkle, James L.; Barr, John R.] Ctr Dis Control & Prevent, Clin Chem Branch, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. RP Williams, TL (reprint author), Ctr Dis Control & Prevent, Clin Chem Branch, Div Sci Lab, Natl Ctr Environm Hlth, 4770 Buford Hwy NE, Atlanta, GA 30341 USA. EM enn8@cdc.gov FU Intramural CDC HHS [CC999999] NR 32 TC 5 Z9 5 U1 2 U2 19 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 EI 1520-6882 J9 ANAL CHEM JI Anal. Chem. PD MAY 6 PY 2014 VL 86 IS 9 BP 4088 EP 4095 DI 10.1021/ac4040778 PG 8 WC Chemistry, Analytical SC Chemistry GA AG9DW UT WOS:000335719900004 PM 24689548 ER PT J AU Baytop, C Royal, S McCree, DH Simmons, R Tregerman, R Robinson, C Johnson, WD McLaughlin, M Price, C AF Baytop, Chanza Royal, Scott McCree, Donna Hubbard Simmons, Ron Tregerman, Rebecca Robinson, Carolyn Johnson, Wayne D. McLaughlin, Mike Price, Cristofer TI Comparison of strategies to increase HIV testing among African-American gay, bisexual, and other men who have sex with men in Washington, DC SO AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV LA English DT Article DE African-American; MSM; HIV testing; outreach strategies ID INFECTION AB This paper presents results from a study conducted to compare the relative effectiveness of three strategies - alternate venue testing (AVT), the social network strategy (SNS), and partner counseling and referral services (PCRS; standard care) - for reaching and motivating previously undiagnosed, African-American men who have sex with men (AA MSM) to be tested for HIV. Data were collected between June 2008 and February 2010 at a gay-identified, community-based organization (CBO) serving AA MSM in Washington, DC. Men were eligible to participate if they were 18-64 years old, self-identified as black or African-American, were biologically male, and self-reported oral or anal sex with a man in the past six months. Fisher's exact test of independence was used to assess differences in demographics, testing history, HIV status and sexual behaviors across the three strategies. The final sample included 470 men who met all eligibility requirements. There were no statistically significant differences in HIV positivity rates across the three strategies. However, relative to standard care, the SNS, and (to a lesser degree) the AVT strategies were more successful in recruiting men that had never been tested. Additionally, the results indicate that each strategy recruited different subgroups of men. Specifically, heterosexually identified men and men who reported engaging in unprotected sex were most likely to be recruited via SNS. Bisexually identified men and older men were most likely to be recruited via AVT or SNS, while standard care tended to reach greater proportions of young men and homosexually identified men. These findings suggest that a combination of strategies may be the best approach for engaging African-American MSM in HIV testing. C1 [Baytop, Chanza; Royal, Scott; Tregerman, Rebecca; Robinson, Carolyn] ABT Associates Inc, US Hlt, Bethesda, MD 20814 USA. [McCree, Donna Hubbard; Johnson, Wayne D.] Ctr Dis Control & Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. [Simmons, Ron] People Into Living Inc, Us Helping Us, Washington, DC USA. [McLaughlin, Mike; Price, Cristofer] ABT Associates Inc, Social & Econ Policy, Bethesda, MD USA. RP Baytop, C (reprint author), ABT Associates Inc, US Hlt, Bethesda, MD 20814 USA. EM chanza_baytop@abtassoc.com FU NCHHSTP CDC HHS [1UR6 PS000330-01] NR 8 TC 5 Z9 5 U1 1 U2 6 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0954-0121 EI 1360-0451 J9 AIDS CARE JI Aids Care-Psychol. Socio-Med. Asp. Aids-Hiv PD MAY 4 PY 2014 VL 26 IS 5 BP 608 EP 612 DI 10.1080/09540121.2013.845280 PG 5 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychology, Multidisciplinary; Respiratory System; Social Sciences, Biomedical SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychology; Respiratory System; Biomedical Social Sciences GA AA8HW UT WOS:000331337200013 PM 24116886 ER PT J AU Fleming, DA Woskie, SR Jones, JH Silver, SR Luo, L Bertke, SJ AF Fleming, Donald A. Woskie, Susan R. Jones, James H. Silver, Sharon R. Luo, Lian Bertke, Stephen J. TI Retrospective Assessment of Exposure to Chemicals for a Microelectronics and Business Machine Manufacturing Facility SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE occupational exposure; circuit board manufacture; substrate production; exposure matrix; exposure score; chlorinated solvents; trichloroethylene; perchloroethylene ID BREAST-CANCER AB A retrospective exposure assessment was performed for use in a health outcomes study of a facility manufacturing circuit boards, business machines, and other equipment during the years 1969-2002. A matrix was developed identifying chemical use by department-year based on company-provided information. Use of six chemical agents (fiberglass, lead, methylene chloride, methyl chloroform, perchloroethylene, and trichloroethylene) and six chemical classes (acid-base, aromatic hydrocarbons, chlorinated hydrocarbons, other hydrocarbons, chlorofluorocarbons, and metals), and general (including unspecified) chemicals was identified. The matrix also contained an assignment for each department-year categorizing the potential for use of chemicals as negligible, intermittent/incidental, or routine. These department-based exposure matrix data were combined with work history data to provide duration of potential chemical use for workers. Negligible, intermittent/incidental or routine extent-of-chemical-use categories comprised 42.6%, 39.4%, and 17.9%, respectively, of total person-years of employment. Cumulative exposure scores were also developed, representing a relative measure of the cumulative extent of potential exposure to the six chemical agents, six chemical classes, and general (including unspecified) chemicals. Additionally, the study period was divided into manufacturing eras showing trends in chemical use, and showing that process use of trichloroethylene and methylene chloride ended in the mid-1980s and the mid-1990s, respectively. This approach may be useful in other assessments addressing a variety of chemicals, and with data constraints common to retrospective chemical exposure studies. C1 [Fleming, Donald A.; Silver, Sharon R.; Bertke, Stephen J.] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Ind Wide Studies Branch, Cincinnati, OH 45226 USA. [Woskie, Susan R.] Univ Massachusetts, Dept Work Environm, Lowell, MA USA. [Jones, James H.] Jones Ind Hyg Serv LLC, Loveland, OH USA. [Luo, Lian] CACI Inc, Arlington, VA USA. RP Fleming, DA (reprint author), 4676 Columbia Pkwy,MS R-14, Cincinnati, OH 45226 USA. EM dmf9@cdc.gov OI Silver, Sharon/0000-0002-7679-5028 FU National Institute for Occupational Safety and Health FX The authors wish to acknowledge the assistance of numerous members of the NIOSH Industry-wide Studies Branch who were instrumental in the planning and conduct of the site visits to collect company data; to organize, review, and store records; and to facilitate this work. In particular we wish to recognize Chris Gersic, Jean Geiman, Denise Giglio, Delores Montgomery, Surprese Watts, Faith Armstrong, Bill Ehling, and Kim Jenkins for data capture and coding. Kevin L. Dunn assisted in the document reviews, Steve Allee provided programming assistance, and Lynne Pinkerton provided consulting on the overall study and objectives. Funding for this research was provided by the National Institute for Occupational Safety and Health. NR 8 TC 2 Z9 2 U1 0 U2 4 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 520 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PD MAY 4 PY 2014 VL 11 IS 5 BP 292 EP 305 DI 10.1080/15459624.2013.862591 PG 14 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AE8QG UT WOS:000334265800006 PM 24224613 ER PT J AU Ceballos, D Reeb-Whitaker, C Glazer, P Murphy-Robinson, H Yost, M AF Ceballos, Diana Reeb-Whitaker, Carolyn Glazer, Patricia Murphy-Robinson, Helen Yost, Michael TI Understanding Factors That Influence Protective Glove Use Among Automotive Spray Painters SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE focus groups; interviews; automotive paints; spray painters; car painters; protective glove; nitrile; latex; butyl rubber ID COLLISION REPAIR INDUSTRY; OCCUPATIONAL-EXPOSURE; NEUROLOGICAL SYMPTOMS; ISOCYANATE EXPOSURES; ORGANIC-SOLVENTS; SKIN EXPOSURE; ASTHMA; MIXTURES; WORKERS; HEALTH AB Dermal contact with isocyanate-based coatings may lead to systemic respiratory sensitization. The most common isocyanates found in sprayed automotive coatings are monomeric and oligomeric 1,6-hexamethylene diisocyanate (HDI) and isophorone diisocyanate (IPDI). Most spray painters use thin (4-5 mil) latex gloves that are not effective at preventing dermal exposures when spraying isocyanate paints. Personal interviews with collision repair industry personnel and focus groups with spray painters were held to characterize risk awareness, to examine perceptions and challenges concerning protective glove use and selection, and to generate ideas for protective glove use interventions. The most popular gloves among spray painters were thin (4-5 mil) and thick (14 mil) latex. We found that medium to thick (6-8 mil) nitrile were not always perceived as comfortable and were expected to be more expensive than thin (4-5 mil) latex gloves. Of concern is the user's difficulty in distinguishing between nitrile and latex gloves; latex gloves are now sold in different colors including blue, which has traditionally been associated with nitrile gloves. Even though spray painters were familiar with the health hazards related to working with isocyanate paints, most were not always aware that dermal exposure to isocyanates could contribute to the development of occupational asthma. There is a need for more research to identify dermal materials that are protective against sprayed automotive coatings. Automotive spray painters and their employers need to be educated in the selection and use of protective gloves, specifically on attributes such as glove material, color, and thickness. C1 [Ceballos, Diana; Murphy-Robinson, Helen; Yost, Michael] Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA. [Reeb-Whitaker, Carolyn] Washington State Dept Labor & Ind, Safety & Hlth Assessment & Res Prevent SHARP Prog, Olympia, WA 98504 USA. [Glazer, Patricia] Gilmore Res Grp, Seattle, WA USA. RP Ceballos, D (reprint author), NIOSH, 4676 Columbia Pkwy,R-11, Cincinnati, OH 45226 USA. EM DCeballos@cdc.gov FU Automotive Service Association of Washington (ASA-WA); University of Washington Department of Environmental and Occupational Health Sciences; National Occupational Research Agenda Project; National Institute for Occupational Safety and Health [R01 OH009364-01] FX The authors are grateful to the participating spray painters, collision repair industry personnel, and spray training facilities who volunteered in this project. Thanks also to Mark Davey for his help with data analysis. Special thanks for the support provided by the Automotive Service Association of Washington (ASA-WA). The contract grant sponsors were the University of Washington Department of Environmental and Occupational Health Sciences and the National Occupational Research Agenda Project. Financial support was provided by the National Institute for Occupational Safety and Health (grant number: R01 OH009364-01). NR 39 TC 1 Z9 1 U1 2 U2 7 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 520 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PD MAY 4 PY 2014 VL 11 IS 5 BP 306 EP 313 DI 10.1080/15459624.2013.862592 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AE8QG UT WOS:000334265800007 PM 24215135 ER PT J AU Roberge, RJ Palmiero, AJ Liu, YW Kim, JH Zhuang, ZQ AF Roberge, Raymond J. Palmiero, Andrew J. Liu, Yuewei Kim, Jung-Hyun Zhuang, Ziqing TI Effect of Upper Strap Downward Displacement on N95 Filtering Facepiece Respirator Fit Factors: A Pilot Study SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE displacement; fit factors; N95 filtering facepiece respirators; top strap AB Fifteen subjects underwent three replicates of quantitative respirator fit-testing with N95 filtering facepiece respirators that were donned with the upper strap high on the occiput, as per the manufacturers' donning instructions. Each fit-test was immediately followed by repeat fit-testing with the upper strap downwardly displaced to the level of the ear sulcus to determine any change in fit factors that might occur with upper strap downward slippage. A total of 35/45 (78%) initial fit-tests had a passing score (fit factor 100) with the top strap high on the occiput and 33/35 (94%) of these passed subsequent fit-testing after the top strap was displaced downward to the ear sulcus. Geometric mean fit factors for the initial passed fit-tests, and following downward strap displacement, were 217 +/- 1.6 and 207 +/- 1.9, respectively (p = 0.64). Downward displacement of the top strap did not significantly impact fit factors of N95 FFRs that had previously passed fit-testing. C1 [Roberge, Raymond J.; Palmiero, Andrew J.; Liu, Yuewei; Kim, Jung-Hyun; Zhuang, Ziqing] NIOSH, Natl Personal Protect Technol Lab, Ctr Dis Control & Prevent, Pittsburgh, PA 15236 USA. RP Roberge, RJ (reprint author), NIOSH, Natl Personal Protect Technol Lab, Ctr Dis Control & Prevent, 626 Cochrans Mill Rd,POB 18070, Pittsburgh, PA 15236 USA. EM dtn0@cdc.gov RI Zhuang, Ziqing/K-5462-2012 FU Intramural CDC HHS [CC999999] NR 20 TC 0 Z9 0 U1 0 U2 7 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 520 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PD MAY 4 PY 2014 VL 11 IS 5 BP 338 EP 341 DI 10.1080/15459624.2013.866716 PG 4 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AE8QG UT WOS:000334265800010 PM 24274974 ER PT J AU Graham, SM Sismanidis, C Menzies, HJ Marais, BJ Detjen, AK Black, RE AF Graham, Stephen M. Sismanidis, Charalambos Menzies, Heather J. Marais, Ben J. Detjen, Anne K. Black, Robert E. TI Importance of tuberculosis control to address child survival SO LANCET LA English DT Editorial Material ID SEVERE PNEUMONIA; MORTALITY; MENINGITIS; AFRICA C1 [Graham, Stephen M.] Univ Melbourne, Ctr Int Child Hlth, Dept Paediat, Melbourne, Vic, Australia. [Graham, Stephen M.] Royal Childrens Hosp, Murdoch Childrens Res Inst, Melbourne, Vic, Australia. [Graham, Stephen M.; Detjen, Anne K.] Int Union TB & Lung Dis, Paris, France. [Sismanidis, Charalambos] WHO, Global TB Programme, CH-1211 Geneva, Switzerland. [Menzies, Heather J.] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Marais, Ben J.] Univ Sydney, Sydney Emerging Infect Dis & Biosecur Inst SEIB, Sydney Med Sch, Sydney, NSW 2006, Australia. [Marais, Ben J.] Univ Sydney, Childrens Hosp Westmead, Sydney Med Sch, Sydney, NSW 2006, Australia. [Black, Robert E.] Johns Hopkins Bloomberg Sch Publ Hlth, Inst Int Programs, Baltimore, MD USA. RP Graham, SM (reprint author), Univ Melbourne, Royal Childrens Hosp, Ctr Int Child Hlth, Dept Paediat, Flemington Rd, Parkville, Vic 3052, Australia. EM steve.graham@rch.org.au FU World Health Organization [001] NR 22 TC 33 Z9 34 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0140-6736 EI 1474-547X J9 LANCET JI Lancet PD MAY 3 PY 2014 VL 383 IS 9928 BP 1605 EP 1607 DI 10.1016/S0140-6736(14)60420-7 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA AG5YO UT WOS:000335495400032 PM 24671079 ER PT J AU Mohamed, AH Dalal, W Nyoka, R Burke, H Ahmed, J Auko, E Shihaji, W Ndege, I Breiman, RF Eidex, RB AF Mohamed, Abdinoor Haji Dalal, Warren Nyoka, Raymond Burke, Heather Ahmed, Jamal Auko, Erick Shihaji, Wilbert Ndege, Irene Breiman, Robert F. Eidex, Rachel B. TI Health care utilization for acute illnesses in an urban setting with a refugee population in Nairobi, Kenya: a cross-sectional survey SO BMC HEALTH SERVICES RESEARCH LA English DT Article DE Health care utilization; Urban refugees; Eastleigh; Kenya ID RURAL KENYA; NEEDS AB Background: Estimates place the number of refugees in Nairobi over 100,000. The constant movement of refugees between countries of origin, refugee camps, and Nairobi poses risk of introduction and transmission of communicable diseases into Kenya. We assessed the care-seeking behavior of residents of Eastleigh, a neighborhood in Nairobi with urban refugees. Methods: During July and August 2010, we conducted a Health Utilization Survey in Section II of Eastleigh. We used a multistage random cluster sampling design to identify households for interview. A standard questionnaire on the household demographics, water and sanitation was administered to household caretakers. Separate questionnaires were administered to household members who had one or more of the illnesses of interest. Results: Of 785 households targeted for interview, data were obtained from 673 (85.7%) households with 3,005 residents. Of the surveyed respondents, 290 (9.7%) individuals reported acute respiratory illness (ARI) in the previous 12 months, 222 (7.4%) reported fever in the preceding 2 weeks, and 54 (1.8%) reported having diarrhea in the 30 days prior to the survey. Children <5 years old had the highest frequency of all the illnesses surveyed: 17.1% (95% CI 12.2-21.9) reported ARI, 10.0% (95% CI 6.2-13.8) reported fever, and 6.9% (3.8-10.0) reported diarrhea during the time periods specified for each syndrome. Twenty-nine [7.5% (95% CI 4.3-10.7)] hospitalizations were reported among all age groups of those who sought care. Among participants who reported >= 1 illness, 330 (77.0%) sought some form of health care; most (174 [59.8%]) sought health care services from private health care providers. Fifty-five (18.9%) participants seeking healthcare services visited a pharmacy. Few residents of Eastleigh (38 [13.1%]) sought care at government-run facilities, and 24 (8.2%) sought care from a relative, a religious leader, or a health volunteer. Of those who did not seek any health care services (99 [23.0%]), the primary reason was cost (44.8%), followed by belief that the person was not sick enough (34.6%). Conclusion: Health care utilization in Eastleigh is high; however, a large proportion of residents opt to seek care at private clinics or pharmacies, despite the availability of accessible government-provided health care services in this area. C1 [Mohamed, Abdinoor Haji; Auko, Erick; Ndege, Irene] Kenya Govt Med Res Ctr, Nairobi, Kenya. [Dalal, Warren; Burke, Heather; Eidex, Rachel B.] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA USA. [Nyoka, Raymond; Ahmed, Jamal; Breiman, Robert F.; Eidex, Rachel B.] US Ctr Dis Control & Prevent, Refugee Hlth Program Africa, Nairobi, Kenya. [Shihaji, Wilbert] Int Org Migrat, Nairobi, Kenya. RP Mohamed, AH (reprint author), Kenya Govt Med Res Ctr, Mbagathi Rd Mbagathi Way,KEMRI Main Campus, Nairobi, Kenya. EM cabeynuurdr@gmail.com NR 31 TC 0 Z9 0 U1 1 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1472-6963 J9 BMC HEALTH SERV RES JI BMC Health Serv. Res. PD MAY 2 PY 2014 VL 14 AR 200 DI 10.1186/1472-6963-14-200 PG 11 WC Health Care Sciences & Services SC Health Care Sciences & Services GA AH3VY UT WOS:000336055400001 PM 24885336 ER PT J AU Yoon, PW Bastian, B Anderson, RN Collins, JL Jaffe, HW AF Yoon, Paula W. Bastian, Brigham Anderson, Robert N. Collins, Janet L. Jaffe, Harold W. TI Potentially Preventable Deaths from the Five Leading Causes of Death - United States, 2008-2010 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Bastian, Brigham; Anderson, Robert N.] Natl Ctr Hlth Stat, Div Vital Stat, Hyattsville, MD USA. [Collins, Janet L.] Natl Ctr Chron Dis Prevent & Hlth Promot, Div Nutr Phys Act & Obes, Atlanta, GA USA. [Jaffe, Harold W.] CDC, Off Associate Director Sci, Atlanta, GA 30333 USA. EM pyoon@cdc.gov NR 9 TC 38 Z9 39 U1 3 U2 10 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAY 2 PY 2014 VL 63 IS 17 BP 369 EP 374 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AG6GL UT WOS:000335517000001 PM 24785982 ER PT J AU Zeigler, M Claar, C Rice, D Davis, J Frazier, T Turner, A Kelley, C Capps, J Kent, A Hubbard, V Ritenour, C Tuscano, C Qiu-Shultz, Z Leaumont, CF AF Zeigler, Mariah Claar, Chad Rice, Daviesha Davis, Jack Frazier, Tammy Turner, Alex Kelley, Corinna Capps, Jonathan Kent, Andrea Hubbard, Valerie Ritenour, Christiana Tuscano, Cristina Qiu-Shultz, Zuwen Leaumont, Collette Fitzgerald TI Outbreak of Campylobacteriosis Associated with a Long-Distance Obstacle Adventure Race - Nevada, October 2012 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID JEJUNI; COLI C1 [Zeigler, Mariah; Claar, Chad; Rice, Daviesha; Davis, Jack; Frazier, Tammy; Turner, Alex; Kelley, Corinna; Capps, Jonathan; Kent, Andrea; Hubbard, Valerie; Ritenour, Christiana; Tuscano, Cristina] Nellis Air Force Base Publ Hlth Flight, Nellis Air Force Base, NV 89191 USA. [Qiu-Shultz, Zuwen] Southern Nevada Hlth Dist, Las Vegas, NV USA. [Leaumont, Collette Fitzgerald] CDC, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. RP Claar, C (reprint author), Nellis Air Force Base Publ Hlth Flight, Nellis Air Force Base, NV 89191 USA. EM chad.claar@nellis.af.mil NR 10 TC 6 Z9 7 U1 0 U2 3 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAY 2 PY 2014 VL 63 IS 17 BP 375 EP 378 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AG6GL UT WOS:000335517000002 PM 24785983 ER PT J AU Barbour, KE Stevens, JA Helmick, CG Luo, YH Murphy, LB Hootman, JM Theis, K Anderson, LA Baker, NA Sugerman, DE AF Barbour, Kamil E. Stevens, Judy A. Helmick, Charles G. Luo, Yao-Hua Murphy, Louise B. Hootman, Jennifer M. Theis, Kristina Anderson, Lynda A. Baker, Nancy A. Sugerman, David E. TI Falls and Fall Injuries Among Adults with Arthritis - United States, 2012 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID PREVALENCE C1 [Barbour, Kamil E.; Helmick, Charles G.; Luo, Yao-Hua; Murphy, Louise B.; Hootman, Jennifer M.; Theis, Kristina; Anderson, Lynda A.] CDC, Div Populat Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Stevens, Judy A.; Sugerman, David E.] CDC, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA. [Baker, Nancy A.] Univ Pittsburgh, Dept Occupat Therapy, Pittsburgh, PA 15260 USA. RP Barbour, KE (reprint author), CDC, Div Populat Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. EM kbarbour@cdc.gov NR 10 TC 13 Z9 13 U1 0 U2 4 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAY 2 PY 2014 VL 63 IS 17 BP 379 EP 383 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AG6GL UT WOS:000335517000003 PM 24785984 ER PT J AU de Perio, MA Bernard, BP Delaney, LJ Pesik, N Cohen, NJ AF de Perio, Marie A. Bernard, Bruce P. Delaney, Lisa J. Pesik, Nicki Cohen, Nicole J. TI Investigation of Infectious Disease Risks Associated With a Nontransplant Anatomical Donation Center - Arizona, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [de Perio, Marie A.; Bernard, Bruce P.; Delaney, Lisa J.] CDC, Natl Inst Occupat Safety & Hlth, Atlanta, GA 30333 USA. [Pesik, Nicki; Cohen, Nicole J.] CDC, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. RP de Perio, MA (reprint author), CDC, Natl Inst Occupat Safety & Hlth, Atlanta, GA 30333 USA. EM mdeperio@cdc.gov NR 3 TC 0 Z9 0 U1 0 U2 1 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAY 2 PY 2014 VL 63 IS 17 BP 384 EP 385 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AG6GL UT WOS:000335517000004 PM 24785985 ER PT J AU Mitchell, T Massoudi, M Swerdlow, DL Dee, DL Gould, LH Kutty, PK Prime, MS Silverman, PR Fishbein, DB AF Mitchell, Tarissa Massoudi, Mehran Swerdlow, David L. Dee, Deborah L. Gould, L. Hannah Kutty, Preeta K. Prime, Marilyn S. Silverman, Paul R. Fishbein, Daniel B. TI Swine Flu in College: Early Campus Response to Outbreak Control Measures SO AMERICAN JOURNAL OF HEALTH BEHAVIOR LA English DT Article DE pandemics; H1N1Virus; universities; prevention and control ID INFLUENZA-A H1N1; APRIL-MAY 2009; NONPHARMACEUTICAL INTERVENTIONS; PANDEMIC INFLUENZA; PUBLIC UNIVERSITY; A(H1N1) AB Objectives: To describe student and faculty attitudes towards and adherence to nonpharmaceutical control measures during the first-known university outbreak of 2009 pandemic influenza A (H1N1). Methods: Preferred information sources, control measure adherence and likelihood of adherence during future outbreaks, and perceived illness risk, were explored through focus groups and patient interviews. Results: We conducted 7 focus groups (N=48) and 9 patient interviews. Measures (eg, hand hygiene, self-isolation while ill) were initially heeded. Limited information regarding A(H1N1) pdm09, insufficient understanding of university decisions, and perceived university alert overuse led to reports that future outbreaks would be regarded less seriously. Conclusions: Reported concern and commitment to recommendations decreased rapidly. Initial university messaging and response was critical in shaping participants' later perceptions. C1 [Mitchell, Tarissa; Fishbein, Daniel B.] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA 30333 USA. [Mitchell, Tarissa] Southeast Permanente Med Grp, Atlanta, GA USA. [Massoudi, Mehran] Ctr Dis Control & Prevent, Div Populat Hlth, Atlanta, GA USA. [Swerdlow, David L.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Dee, Deborah L.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA. [Gould, L. Hannah] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Atlanta, GA USA. [Kutty, Preeta K.] Ctr Dis Control & Prevent, Div Bacterial Dis, Atlanta, GA USA. [Prime, Marilyn S.] Univ Delaware, Student Ctr, Newark, DE USA. [Silverman, Paul R.] Delaware Div Publ Hlth, Delaware, OH USA. [Fishbein, Daniel B.] Myanmar Res Int, Yangon, Myanmar. RP Mitchell, T (reprint author), Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA 30333 USA. EM TMitchell1@cdc.gov NR 22 TC 1 Z9 1 U1 0 U2 162 PU PNG PUBLICATIONS PI OAK RIDGE PA 2205-K OAK RIDGE RD, #115, OAK RIDGE, NC 27310 USA SN 1945-7359 J9 AM J HEALTH BEHAV JI Am. J. Health Behav. PD MAY PY 2014 VL 38 IS 3 BP 448 EP 464 DI 10.5993/AJHB.38.3.14 PG 17 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AS1JB UT WOS:000344036300014 PM 25181765 ER PT J AU Bi, ZQ Liang, XF Xu, AQ Wang, LH Shi, XM Zhao, WH Ma, JX Guo, XL Zhang, XF Zhang, JY Ren, J Yan, LX Lu, ZL Wang, HC Tang, JL Cai, XN Dong, J Zhang, J Chu, J Engelgau, M Yang, QH Hong, YL Wang, Y AF Bi, Zhenqiang Liang, Xiaofeng Xu, Aiqiang Wang, Linghong Shi, Xiaoming Zhao, Wenhua Ma, Jixiang Guo, Xiaolei Zhang, Xiaofei Zhang, Jiyu Ren, Jie Yan, Liuxia Lu, Zilong Wang, Huicheng Tang, Junli Cai, Xiaoning Dong, Jing Zhang, Juan Chu, Jie Engelgau, Michael Yang, Quanhe Hong, Yuling Wang, Yu TI Hypertension Prevalence, Awareness, Treatment, and Control and Sodium Intake in Shandong Province, China: Baseline Results From Shandong-Ministry of Health Action on Salt Reduction and Hypertension (SMASH), 2011 SO PREVENTING CHRONIC DISEASE LA English DT Article ID DIETARY; TRENDS AB Introduction In China, population-based blood pressure levels and prevalence of hypertension are increasing. Meanwhile, sodium intake, a major risk factor for hypertension, is high. In 2011, to develop intervention priorities for a salt reduction and hypertension control project in Shandong Province (population 96 million), a cross-sectional survey was conducted to collect information on sodium intake and hypertension prevalence, awareness, treatment, and control. Methods Complex, multistage sampling methods were used to select a provincial-representative adult sample. Blood pressure was measured and a survey conducted among all participants; condiments were weighed in the household, a 24-hour dietary recall was conducted, and urine was collected. Hypertension was determined by blood pressure measured on a single occasion and self-reported use of antihypertension medications. Results Overall, 23.4% (95% confidence interval [CI], 20.9%-26.0%) of adults in Shandong were estimated to have hypertension. Among those classified as having hypertension, approximately one-third (34.5%) reported having hypertension, approximately one-fourth (27.5%) reported taking medications, and one-seventh (14.9%) had their blood pressure controlled (<140/<90 mm Hg). Estimated total average daily dietary sodium intake was 5,745 mg (95% CI, 5,428 mg-6,063 mg). Most dietary sodium (80.8%) came from salt and high-salt condiments added during cooking: a sodium intake of 4,640 mg (95% CI, 4,360 mg-4,920 mg). The average daily urinary sodium excretion was 5,398 mg (95% CI, 5,112 mg-5,683 mg). Conclusion Hypertension and excessive sodium intake in adults are major public health problems in Shandong Province, China. C1 [Liang, Xiaofeng; Shi, Xiaoming; Zhao, Wenhua; Wang, Huicheng; Zhang, Juan; Wang, Yu] Chinese Ctr Dis Control & Prevent, Beijing 102206, Peoples R China. [Bi, Zhenqiang; Xu, Aiqiang; Guo, Xiaolei; Zhang, Jiyu; Ren, Jie; Lu, Zilong; Tang, Junli; Dong, Jing; Chu, Jie] Shandong Univ, Acad Prevent Med, Jinan 250100, Peoples R China. [Bi, Zhenqiang; Xu, Aiqiang; Guo, Xiaolei; Zhang, Jiyu; Ren, Jie; Lu, Zilong; Tang, Junli; Dong, Jing; Chu, Jie] Shandong Ctr Dis Control & Prevent, Jinan, Peoples R China. [Wang, Linghong; Ma, Jixiang; Yan, Liuxia; Cai, Xiaoning] Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing 102206, Peoples R China. [Zhang, Xiaofei] Zhejiang Univ, Coll Med, Affiliated Hosp 2, Hangzhou 310003, Zhejiang, Peoples R China. [Engelgau, Michael; Yang, Quanhe; Hong, Yuling] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Wang, Y (reprint author), Chinese Ctr Dis Control & Prevent, 155 Changbai Rd, Beijing 102206, Peoples R China. EM wangyu@chinacdc.cn FU Chinese Center for Disease Control and Prevention (CDC); National Center for Non-communicable and Chronic Disease Control and Prevention; Technical Development Plan in Shandong [2012GSF11828] FX The survey was supported by funds from Chinese Center for Disease Control and Prevention (CDC), National Center for Non-communicable and Chronic Disease Control and Prevention, the Technical Development Plan in Shandong (implemented by Shandong CDC, grant no. 2012GSF11828). We thank all investigators from the national, provincial, and county-level CDC and all participants of the survey. We also acknowledge Ying Cai and Sonia Angell for their review of the study design and advice on implementation of the field intervention. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the US Centers for Disease Control and Prevention. There are no conflicts of interest relevant to this article. NR 30 TC 5 Z9 5 U1 0 U2 16 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD MAY PY 2014 VL 11 AR 130423 DI 10.5888/pcd11.130423 PG 15 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AR3XH UT WOS:000343522000021 ER PT J AU Greer, S Schieb, L Schwartz, G Onufrak, S Park, S AF Greer, Sophia Schieb, Linda Schwartz, Greg Onufrak, Stephen Park, Sohyun TI Association of the Neighborhood Retail Food Environment with Sodium and Potassium Intake Among US Adults SO PREVENTING CHRONIC DISEASE LA English DT Article ID LOWER MISSISSIPPI DELTA; ATHEROSCLEROSIS RISK; UNITED-STATES; STORES; AVAILABILITY; SUPERMARKETS; COMMUNITIES; POPULATION; VEGETABLES; OBESITY AB Introduction High sodium intake and low potassium intake, which can contribute to hypertension and risk of cardiovascular disease, may be related to the availability of healthful food in neighborhood stores. Despite evidence linking food environment with diet quality, this relationship has not been evaluated in the United States. The modified retail food environment index (mRFEI) provides a composite measure of the retail food environment and represents the percentage of healthful-food vendors within a 0.5 mile buffer of a census tract. Methods We analyzed data from 8,779 participants in the National Health and Nutrition Examination Survey, 2005-2008. By using linear regression, we assessed the relationship between mRFEI and sodium intake, potassium intake, and the sodium potassium ratio. Models were stratified by region (South and non-South) and included participant and neighborhood characteristics. Results In the non-South region, higher mRFEI scores (indicating a more healthful food environment) were not associated with sodium intake, were positively associated with potassium intake (P [trend] = .005), and were negatively associated with the sodium potassium ratio (P [trend] = .02); these associations diminished when neighborhood characteristics were included, but remained close to statistical significance for potassium intake (P [trend] = .05) and sodium potassium ratio (P [trend] = .07). In the South, mRFEI scores were not associated with sodium intake, were negatively associated with potassium intake (P [trend] = < .001), and were positively associated with sodium potassium ratio (P [trend] = .01). These associations also diminished after controlling for neighborhood characteristics for both potassium intake (P [trend] = .03) and sodium potassium ratio (P [trend] = .40). Conclusion We found no association between mRFEI and sodium intake. The association between mRFEI and potassium intake and the sodium potassium ratio varied by region. National strategies to reduce sodium in the food supply may be most effective to reduce sodium intake. Strategies aimed at the local level should consider regional context and neighborhood characteristics. C1 [Greer, Sophia; Schieb, Linda; Onufrak, Stephen; Park, Sohyun] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Schwartz, Greg] Vet Hlth Adm, Seattle, WA USA. RP Greer, S (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy NE,MS F-72, Atlanta, GA 30341 USA. EM sgreer@cdc.gov NR 28 TC 1 Z9 1 U1 1 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD MAY PY 2014 VL 11 AR 130340 DI 10.5888/pcd11.130340 PG 12 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AR3XH UT WOS:000343522000014 ER PT J AU Valdiserri, R Khalsa, J Dan, C Holmberg, S Zibbell, J Holtzman, D Lubran, R Compton, W AF Valdiserri, Ronald Khalsa, Jag Dan, Corinna Holmberg, Scott Zibbell, Jon Holtzman, Deborah Lubran, Robert Compton, Wilson TI Confronting the Emerging Epidemic of HCV Infection Among Young Injection Drug Users SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID HEPATITIS-C VIRUS; UNITED-STATES; USE DISORDERS; NEW-YORK; RISK; ABUSE; ADOLESCENTS; HEALTH; ADULTS; HIV AB Hepatitis C virus infection is a significant public health problem in the United States and an important cause of morbidity and mortality. Recent reports document HCV infection increases among young injection drug users in several US regions, associated with America's prescription opioid abuse epidemic. Incident HCV infection increases among young injectors who have recently transitioned from oral opioid abuse present an important public health challenge requiring a comprehensive, community-based response. We summarize recommendations from a 2013 Office of HIV/AIDS and Infectious Disease Policy convening of experts in epidemiology, behavioral science, drug prevention and treatment, and other research; community service providers; and federal, state, and local government representatives. Their observations highlight gaps in our surveillance, program, and research portfolios and advocate a syndemic approach to this emerging public health problem. C1 [Valdiserri, Ronald; Dan, Corinna] US Dept HHS, Off HIV AIDS & Infect Dis Policy, Washington, DC 20201 USA. [Khalsa, Jag; Compton, Wilson] NIDA, Bethesda, MD 20892 USA. [Lubran, Robert] Subst Abuse & Mental Hlth Serv Adm, Rockville, MD USA. [Holmberg, Scott; Zibbell, Jon; Holtzman, Deborah] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Valdiserri, R (reprint author), US Dept HHS, 200 Independence Ave SW,Room 443-H, Washington, DC 20201 USA. EM ron.valdiserri@hhs.gov OI Lubran, Robert/0000-0003-1235-5207 NR 51 TC 28 Z9 28 U1 2 U2 6 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD MAY PY 2014 VL 104 IS 5 BP 816 EP 821 DI 10.2105/AJPH.2013.301812 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AP0XU UT WOS:000341790600022 PM 24625174 ER PT J AU Anderson, AR Welles, WL Drew, J Orr, MF AF Anderson, Ayana R. Welles, Wanda Lizak Drew, James Orr, Maureen F. TI The Distribution and Public Health Consequences of Releases of Chemicals Intended for Pool Use in 17 States, 2001-2009 SO JOURNAL OF ENVIRONMENTAL HEALTH LA English DT Article ID UNITED-STATES; SWIMMING POOLS; EXPOSURE; CHLORINE; EVENTS AB To keep swimming pool water clean and clear, consumers purchase, transport, store, use, and dispose of large amounts of potentially hazardous chemicals. Data about incidents due to the use of these chemicals and the resultant public health impacts are limited. The authors analyzed pool chemical release data from 17 states that participated in the Agency for Toxic Substances and Disease Registry's chemical event surveillance system during 2001-2009. In 400 pool chemical incidents, 60% resulted in injuries. Of the 732 injured persons, 67% were members of the public and 50% were under 18 years old. Incidents occurred most frequently in private residences (39%), but incidents with the most injured persons (34%) occurred at recreational facilities. Human error (71.9%) was the most frequent primary contributing factor, followed by equipment failure (22.8%). Interventions designed to mitigate the public health impact associated with pool chemical releases should target both private pool owners and public pool operators. C1 [Anderson, Ayana R.; Orr, Maureen F.] Agcy Tox Subst & Dis Registry, Div Toxicol & Human Hlth Sci, Atlanta, GA 30341 USA. [Welles, Wanda Lizak] New York State Dept Hlth, Bur Tox Subst Assessment, Albany, NY 12237 USA. [Drew, James] Wisconsin Dept Hlth Serv, Bur Environm & Occupat Hlth, Madison, WI USA. RP Anderson, AR (reprint author), Agcy Tox Subst & Dis Registry, Div Toxicol & Human Hlth Sci, 4770 Buford Hwy,MS F58, Atlanta, GA 30341 USA. EM ing9@cdc.gov NR 18 TC 3 Z9 3 U1 0 U2 2 PU NATL ENVIRON HEALTH ASSOC PI DENVER PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA SN 0022-0892 J9 J ENVIRON HEALTH JI J. Environ. Health PD MAY PY 2014 VL 76 IS 9 BP 10 EP 15 PG 6 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AO7NT UT WOS:000341540600002 PM 24909007 ER PT J AU Blake, R AF Blake, Robert TI Update on the Model Aquatic Health Code SO JOURNAL OF ENVIRONMENTAL HEALTH LA English DT Article ID SWIMMING POOL AB NEHA strives to provide up-to-date and relevant information on environmental health and to build partnerships in the profession. In pursuit of these goals, we feature a column from the Environmental Health Services Branch (EHSB) of the Centers for Disease Control and Prevention (CDC) in every issue of the Journal. In this column, EHSB and guest authors from across CDC will highlight a variety of concerns, opportunities, challenges, and successes that we all share in environmental public health. EHSB's objective is to strengthen the role of state, local, tribal, and national environmental health programs and professionals to anticipate, identify, and respond to adverse environmental exposures and the consequences of these exposures for human health. The conclusions in this article are those of the author(s) and do not necessarily represent the views of CDC. Robert Blake is a health scientist of the EHSB at CDC and has been working in the environmental health field for more than 30 years. C1 CDC, Div Emergency & Environm Hlth Serv, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. RP Blake, R (reprint author), CDC, Div Emergency & Environm Hlth Serv, Natl Ctr Environm Hlth, 4770 Buford Highway NE,MS F-58, Atlanta, GA 30341 USA. EM rgblake@cdc.gov FU CLC NIH HHS [NIH0010192010] NR 4 TC 0 Z9 0 U1 0 U2 1 PU NATL ENVIRON HEALTH ASSOC PI DENVER PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA SN 0022-0892 J9 J ENVIRON HEALTH JI J. Environ. Health PD MAY PY 2014 VL 76 IS 9 BP 34 EP + PG 3 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AO7NT UT WOS:000341540600006 PM 24909011 ER PT J AU Moore, JM AF Moore, Jennifer M. TI CDC's National Environmental Public Health Tracking Network Classroom Modules SO JOURNAL OF ENVIRONMENTAL HEALTH LA English DT Article AB As part of our continuing effort to highlight innovative approaches and tools to improve the health and environment of communities, the Journal is pleased to publish a bimonthly column from the Centers for Disease Control and Prevention's (CDC's) Environmental Public Health Tracking Network (Tracking Network). The Tracking Network is a system of integrated health, exposure, and hazard information and data from a variety of national, state, and city sources. The Tracking Network brings together data concerning health and environmental problems with the goal of providing information to help improve where we live, work, and play. Environmental causes of chronic diseases are hard to identify Measuring amounts of hazardous substances in our environment in a standard way, tracing the spread of these over time and area, seeing how they show up in human tissues, and understanding how they may cause illness is critical. The Tracking Network is a tool that can help connect these efforts. Through these columns, readers will learn about the program and the resources, tools, and information available from CDC's Tracking Network. The conclusions of this article are those of the author(s) and do not necessarily represent the views of CDC. Jennifer Moore is a health communication specialist within CDC's Environmental Health Tracking Branch and has been with CDC for six years. She has extensive experience in health communications and education. C1 CDC, Environm Hlth Tracking Branch, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. RP Moore, JM (reprint author), CDC, Environm Hlth Tracking Branch, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, 4770 Buford Highway NE,MS F-60, Atlanta, GA 30341 USA. EM JMMoore@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 2 PU NATL ENVIRON HEALTH ASSOC PI DENVER PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA SN 0022-0892 J9 J ENVIRON HEALTH JI J. Environ. Health PD MAY PY 2014 VL 76 IS 9 BP 38 EP 39 PG 2 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AO7NT UT WOS:000341540600007 PM 24909012 ER PT J AU Yokoe, DS Anderson, DJ Berenholtz, SM Calfee, DP Dubberke, ER Ellingson, K Gerding, DN Haas, J Kaye, KS Klompas, M Lo, E Marschall, J Mermel, LA Nicolle, L Salgado, C Bryant, K Classen, D Crist, K Foster, N Humphreys, E Padberg, J Podgorny, K VanAmringe, M Weaver, T Wise, R Maragakis, LL AF Yokoe, Deborah S. Anderson, Deverick J. Berenholtz, Sean M. Calfee, David P. Dubberke, Erik R. Ellingson, Katherine Gerding, Dale N. Haas, Janet Kaye, Keith S. Klompas, Michael Lo, Evelyn Marschall, Jonas Mermel, Leonard A. Nicolle, Lindsay Salgado, Cassandra Bryant, Kristina Classen, David Crist, Katrina Foster, Nancy Humphreys, Eve Padberg, Jennifer Podgorny, Kelly VanAmringe, Margaret Weaver, Tom Wise, Robert Maragakis, Lisa L. TI Introduction to "A Compendium of Strategies to Prevent Healthcare-Associated Infections in Acute Care Hospitals: 2014 Updates" SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article AB Since the publication of "A Compendium of Strategies to Prevent Healthcare-Associated Infections in Acute Care Hospitals" in 2008, prevention of healthcare-associated infections (HAIs) has become a national priority. Despite improvements, preventable HAIs continue to occur. The 2014 updates to the Compendium were created to provide acute care hospitals with up-to-date, practical, expert guidance to assist in prioritizing and implementing their HAI prevention efforts. It is the product of a highly collaborative effort led by the Society for Healthcare Epidemiology of America (SHEA), the Infectious Diseases Society of America (IDSA), the American Hospital Association (AHA), the Association for Professionals in Infection Control and Epidemiology (APIC), and The Joint Commission, with major contributions from representatives of a number of organizations and societies with content expertise, including the Centers for Disease Control and Prevention (CDC), the Institute for Healthcare Improvement (IHI), the Pediatric Infectious Diseases Society (PIDS), the Society for Critical Care Medicine (SCCM), the Society for Hospital Medicine (SHM), and the Surgical Infection Society (SIS). C1 [Yokoe, Deborah S.; Klompas, Michael] Brigham & Womens Hosp, Boston, MA 02115 USA. [Yokoe, Deborah S.; Klompas, Michael] Harvard Univ, Sch Med, Boston, MA USA. [Anderson, Deverick J.] Duke Univ, Med Ctr, Durham, NC USA. [Berenholtz, Sean M.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Calfee, David P.] Weill Cornell Med Coll, New York, NY USA. [Dubberke, Erik R.; Marschall, Jonas] Washington Univ, Sch Med, St Louis, MO USA. [Ellingson, Katherine] Ctr Dis Control & Prevent, Atlanta, GA USA. [Gerding, Dale N.] Loyola Univ, Chicago Stritch Sch Med, Chicago, IL 60611 USA. [Haas, Janet] Westchester Cty Med Ctr, Valhalla, NY 10595 USA. [Haas, Janet] New York Med Coll, Valhalla, NY 10595 USA. [Kaye, Keith S.] Detroit Med Ctr, Detroit, MI USA. [Kaye, Keith S.] Wayne State Univ, Detroit, MI USA. [Klompas, Michael] Harvard Pilgrim Hlth Care Inst, Boston, MA USA. [Lo, Evelyn] St Boniface Gen Hosp, Winnipeg, MB R2H 2A6, Canada. [Lo, Evelyn; Nicolle, Lindsay] Univ Manitoba, Winnipeg, MB, Canada. [Marschall, Jonas] Univ Hosp Bern, CH-3010 Bern, Switzerland. [Marschall, Jonas] Univ Bern, Bern, Switzerland. [Mermel, Leonard A.] Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USA. [Mermel, Leonard A.] Rhode Isl Hosp, Providence, RI USA. [Nicolle, Lindsay] Hlth Sci Ctr, Winnipeg, MB, Canada. [Salgado, Cassandra] Med Univ S Carolina, Charleston, SC 29425 USA. [Bryant, Kristina] Univ Louisville, Louisville, KY 40292 USA. [Classen, David] Univ Utah, Sch Med, Salt Lake City, UT USA. [Crist, Katrina; Weaver, Tom] Assoc Profess Infect Control & Epidemiol, Washington, DC USA. [Foster, Nancy] Amer Hosp Assoc, Washington, DC USA. [Humphreys, Eve] Soc Healthcare Epidemiol Amer, Arlington, VA USA. [Padberg, Jennifer] Infect Dis Soc Amer, Arlington, VA USA. [Podgorny, Kelly; VanAmringe, Margaret; Wise, Robert] Joint Commiss, Oak Brook Terrace, IL USA. [Maragakis, Lisa L.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. RP Yokoe, DS (reprint author), 181 Longwood Ave, Boston, MA 02115 USA. EM dyokoe@partners.org FU Society for Healthcare Epidemiology of America FX Support for this Compendium was provided by the Society for Healthcare Epidemiology of America. NR 14 TC 0 Z9 0 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X EI 1559-6834 J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD MAY 1 PY 2014 VL 35 IS 5 BP 455 EP 459 DI 10.1086/675819 PG 5 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AE4EI UT WOS:000333933900001 ER PT J AU Lo, E Nicolle, LE Coffin, SE Gould, C Maragakis, LL Meddings, J Pegues, DA Pettis, AM Saint, S Yokoe, DS AF Lo, Evelyn Nicolle, Lindsay E. Coffin, Susan E. Gould, Carolyn Maragakis, Lisa L. Meddings, Jennifer Pegues, David A. Pettis, Ann Marie Saint, Sanjay Yokoe, Deborah S. TI Strategies to Prevent Catheter-Associated Urinary Tract Infections in Acute Care Hospitals: 2014 Update SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; CONTROL CONSORTIUM INICC; NOSOCOMIAL INFECTIONS; DEVELOPING-COUNTRIES; UNITED-STATES; RATES; BACTERIURIA; QUALITY; EPIDEMIOLOGY; RECOMMENDATIONS C1 [Lo, Evelyn] St Boniface Gen Hosp, Winnipeg, MB R2H 2A6, Canada. [Lo, Evelyn; Nicolle, Lindsay E.] Univ Manitoba, Winnipeg, MB, Canada. [Nicolle, Lindsay E.] Hlth Sci Ctr, Winnipeg, MB, Canada. [Coffin, Susan E.] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA. [Gould, Carolyn] Ctr Dis Control & Prevent, Atlanta, GA USA. [Maragakis, Lisa L.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Meddings, Jennifer] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI USA. [Pegues, David A.] Hosp Univ Penn, Philadelphia, PA 19104 USA. [Pegues, David A.] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA. [Pettis, Ann Marie] Univ Rochester, Med Ctr, Rochester, NY 14642 USA. [Saint, Sanjay] Ann Arbor Vet Affairs Med Ctr, Ann Arbor, MI USA. [Saint, Sanjay] Univ Michigan, Ann Arbor, MI 48109 USA. [Yokoe, Deborah S.] Brigham & Womens Hosp, Boston, MA 02115 USA. [Yokoe, Deborah S.] Harvard Univ, Sch Med, Boston, MA USA. RP Nicolle, LE (reprint author), GG 443 Hlth Sci Ctr, 820 Sherbrook St, Winnipeg, MB R3A 1R9, Canada. EM lnicolle@exchange.hsc.mb.ca FU Cangene Corporation FX Authors report the following. E.L.-research grants/contracts: Cangene Corporation, antibody responses to C. difficile-associated diarrhea; research with Virox Industries, HAI response to environmental disinfection. L.E.N.-advisory/consultant role: Cerena, Johnson & Johnson. D.A.P.-advisory/consultant role: InVentiv; honoraria: Health Research and Educational Trust/American Hospital Association, RandHealth. A.M.P.-served as a speaker for Bard; served as a speaker and author for Covidien. S.S.-honoraria and speaking fees for lectures on healthcare-associated infection prevention, implementation science, and patient safety from hospitals, academic medical centers, professional societies, and non-profit foundations (none of these activities are related to speakers' bureaus); medical advisory board: Doximity (a new social networking site for physicians), Jvion (a healthcare technology company). S.E.C., C.G., L.L.M., J.M., D.S.Y.- nothing to disclose. NR 77 TC 0 Z9 0 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X EI 1559-6834 J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD MAY 1 PY 2014 VL 35 IS 5 BP 464 EP 479 DI 10.1086/675718 PG 16 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AE4EI UT WOS:000333933900003 ER PT J AU Battalora, L Buchacz, K Armon, C Overton, ET Hammer, J Patel, P Chmiel, JS Wood, K Brooks, JT Young, B AF Battalora, L. Buchacz, K. Armon, C. Overton, E. T. Hammer, J. Patel, P. Chmiel, J. S. Wood, K. Brooks, J. T. Young, B. TI NEW FRACTURE RISK AND FRAX 10-YEAR PROBABILITY OF FRACTURE IN HIV-INFECTED ADULTS SO VALUE IN HEALTH LA English DT Meeting Abstract C1 [Battalora, L.] Colorado Sch Mines, Golden, CO 80401 USA. [Buchacz, K.; Patel, P.; Brooks, J. T.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Armon, C.; Wood, K.] Cerner Corp, Vienna, VA USA. [Overton, E. T.] Univ Alabama Birmingham, Birmingham, AL USA. [Hammer, J.] Denver Infect Dis Consultants, Denver, CO USA. [Chmiel, J. S.] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA. [Young, B.] Int Assoc Providers AIDS Care, Washington, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1098-3015 EI 1524-4733 J9 VALUE HEALTH JI Value Health PD MAY PY 2014 VL 17 IS 3 MA PIN20 BP A268 EP A268 PG 1 WC Economics; Health Care Sciences & Services; Health Policy & Services SC Business & Economics; Health Care Sciences & Services GA AO1OG UT WOS:000341082001602 ER PT J AU Battalora, L Buchacz, K Armon, C Overton, ET Hammer, J Patel, P Chmiel, JS Bush, TJ Brooks, JT Young, B AF Battalora, L. Buchacz, K. Armon, C. Overton, E. T. Hammer, J. Patel, P. Chmiel, J. S. Bush, T. J. Brooks, J. T. Young, B. TI LOW BONE MINERAL DENSITYIS ASOCIATED WITH INCREASED RISK OF INCIDENT FRACTURE IN HIV plus ADULTS SO VALUE IN HEALTH LA English DT Meeting Abstract C1 [Battalora, L.] Colorado Sch Mines, Golden, CO 80401 USA. [Buchacz, K.; Patel, P.; Bush, T. J.; Brooks, J. T.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Armon, C.] Cerner Corp, Vienna, VA USA. [Overton, E. T.] Univ Alabama Birmingham, Birmingham, AL USA. [Hammer, J.] Denver Infect Dis Consultants, Denver, CO USA. [Chmiel, J. S.] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA. [Young, B.] Int Assoc Providers AIDS Care, Washington, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1098-3015 EI 1524-4733 J9 VALUE HEALTH JI Value Health PD MAY PY 2014 VL 17 IS 3 MA PIN18 BP A268 EP A268 PG 1 WC Economics; Health Care Sciences & Services; Health Policy & Services SC Business & Economics; Health Care Sciences & Services GA AO1OG UT WOS:000341082001600 ER PT J AU Chung, JK Cassell, CH Honein, MA Olney, RS Grosse, SD AF Chung, J. K. Cassell, C. H. Honein, M. A. Olney, R. S. Grosse, S. D. TI HEALTH CARE UTILIZATION AND COSTS AMONG PRIVATELY INSURED CHILDREN WITH OROFACIAL CLEFTS SO VALUE IN HEALTH LA English DT Meeting Abstract C1 [Chung, J. K.; Cassell, C. H.; Honein, M. A.; Olney, R. S.; Grosse, S. D.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1098-3015 EI 1524-4733 J9 VALUE HEALTH JI Value Health PD MAY PY 2014 VL 17 IS 3 MA PIH80 BP A167 EP A168 PG 2 WC Economics; Health Care Sciences & Services; Health Policy & Services SC Business & Economics; Health Care Sciences & Services GA AO1OG UT WOS:000341082001046 ER PT J AU Ekwueme, DU Trogdon, J Khavjou, O Guy, G Li, C AF Ekwueme, D. U. Trogdon, J. Khavjou, O. Guy, Jr G. Li, C. TI ESTIMATING MORBIDITY COSTS ATTRIBUTABLE TO BREAST CANCER AMONG YOUNGER WOMEN AGED 18 TO 44 YEARS-UNITED STATES, 2000-2010 SO VALUE IN HEALTH LA English DT Meeting Abstract C1 [Ekwueme, D. U.; Guy, Jr G.; Li, C.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Trogdon, J.] Univ N Carolina, Chapel Hill, GA USA. [Khavjou, O.] RTI Int, Chapel Hill, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1098-3015 EI 1524-4733 J9 VALUE HEALTH JI Value Health PD MAY PY 2014 VL 17 IS 3 MA PHS28 BP A130 EP A130 PG 1 WC Economics; Health Care Sciences & Services; Health Policy & Services SC Business & Economics; Health Care Sciences & Services GA AO1OG UT WOS:000341082000709 ER PT J AU Ortega-Sanchez, I AF Ortega-Sanchez, I TI REVISITING THE COST-EFFECTIVENESS OF HERPES ZOSTER VACCINATION IN ELDERLY PEOPLE IN THE UNITED STATES SO VALUE IN HEALTH LA English DT Meeting Abstract C1 [Ortega-Sanchez, I] Ctr Dis Control & Prevent CDC, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1098-3015 EI 1524-4733 J9 VALUE HEALTH JI Value Health PD MAY PY 2014 VL 17 IS 3 MA PIH31 BP A159 EP A159 PG 1 WC Economics; Health Care Sciences & Services; Health Policy & Services SC Business & Economics; Health Care Sciences & Services GA AO1OG UT WOS:000341082000873 ER PT J AU Palella, FJ Armon, C Chmiel, JS Brooks, JT Debes, R Novak, RM Yangco, BG Wood, K Durham, M Buchacz, K AF Palella, F. J. Armon, C. Chmiel, J. S. Brooks, J. T. Debes, R. Novak, R. M. Yangco, B. G. Wood, K. Durham, M. Buchacz, K. TI HIGHER CD4 AT ART INITIATION PREDICTS GREATER LONG TERM LIKELIHOOD OF CD4 NORMALIZATION SO VALUE IN HEALTH LA English DT Meeting Abstract C1 [Palella, F. J.; Chmiel, J. S.] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA. [Armon, C.; Wood, K.] Cerner Corp, Vienna, VA USA. [Brooks, J. T.; Durham, M.; Buchacz, K.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Debes, R.] Cerner Corp, North Kansas City, MO USA. [Novak, R. M.] Univ Illinois, Chicago, IL USA. [Yangco, B. G.] Infect Dis Res Inst, Tampa, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1098-3015 EI 1524-4733 J9 VALUE HEALTH JI Value Health PD MAY PY 2014 VL 17 IS 3 MA PIN24 BP A269 EP A269 PG 1 WC Economics; Health Care Sciences & Services; Health Policy & Services SC Business & Economics; Health Care Sciences & Services GA AO1OG UT WOS:000341082001606 ER PT J AU Peasah, SK Purakayastha, DR Koul, P Dawood, F Saha, S Broor, S Rastogi, V Widdowson, MA Lal, R Krishnan, A AF Peasah, S. K. Purakayastha, Ram D. Koul, P. Dawood, F. Saha, S. Broor, S. Rastogi, V Widdowson, M. A. Lal, R. Krishnan, A. TI THE COST OF HOSPITALIZATION DUE TO ACUTE RESPIRATORY INFECTIONS IN NORTHERN INDIA SO VALUE IN HEALTH LA English DT Meeting Abstract C1 [Peasah, S. K.] Mercer Univ, Atlanta, GA USA. [Purakayastha, Ram D.; Krishnan, A.] All India Inst Med Sci, New Delhi, India. [Koul, P.] Sheri Kashmir Inst Med Sci, Srinagar, Jammu & Kashmir, India. [Dawood, F.; Widdowson, M. A.] CDC, Atlanta, GA 30333 USA. [Saha, S.; Lal, R.] CDC India, New Delhi, India. [Broor, S.; Rastogi, V] Inclen Trust Labs, New Delhi, India. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1098-3015 EI 1524-4733 J9 VALUE HEALTH JI Value Health PD MAY PY 2014 VL 17 IS 3 MA PHS33 BP A130 EP A131 PG 2 WC Economics; Health Care Sciences & Services; Health Policy & Services SC Business & Economics; Health Care Sciences & Services GA AO1OG UT WOS:000341082000714 ER PT J AU Zhuo, X AF Zhuo, X. TI TREND OF THE UTILIZATION AND COST OF PRESCRIPTION MEDICATIONS AMONG DIABETES PATIENTS IN THE UNITED STATES: 1987 TO 2010 SO VALUE IN HEALTH LA English DT Meeting Abstract C1 [Zhuo, X.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1098-3015 EI 1524-4733 J9 VALUE HEALTH JI Value Health PD MAY PY 2014 VL 17 IS 3 MA PDB133 BP A261 EP A261 PG 1 WC Economics; Health Care Sciences & Services; Health Policy & Services SC Business & Economics; Health Care Sciences & Services GA AO1OG UT WOS:000341082001562 ER PT J AU Black, MC Basile, KC Breiding, MJ Ryan, GW AF Black, Michele C. Basile, Kathleen C. Breiding, Matthew J. Ryan, George W. TI Prevalence of Sexual Violence Against Women in 23 States and Two US Territories, BRFSS 2005 SO VIOLENCE AGAINST WOMEN LA English DT Article DE prevalence; rape; sexual violence ID DIGIT-DIAL SURVEYS; INJURY-PREVENTION; RAPE; NONRESPONSE; AGGRESSION; SCOPE AB Sexual violence (SV) is a significant public health problem. Using data from the 2005 Behavioral Risk Factor Surveillance System (BRFSS), this article provides state-specific 12-month SV prevalence data for women residing in 23 states and two territories. Overall, more than 500,000 women in the participating states experienced completed or attempted nonconsensual sex in the 12-month period prior to the survey. The collection of state-level data using consistent, uniform, and behaviorally specific SV definitions enables states to evaluate the magnitude of the problem within their state and informs the development and evaluation of state-level SV programs, policies, and prevention efforts. C1 [Black, Michele C.; Basile, Kathleen C.; Breiding, Matthew J.; Ryan, George W.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. RP Basile, KC (reprint author), Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, 4770 Buford Highway NE, Atlanta, GA 30341 USA. EM ksb9@cdc.gov NR 29 TC 1 Z9 1 U1 2 U2 11 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1077-8012 EI 1552-8448 J9 VIOLENCE AGAINST WOM JI Violence Against Women PD MAY PY 2014 VL 20 IS 5 BP 485 EP 499 DI 10.1177/1077801214528856 PG 15 WC Women's Studies SC Women's Studies GA AN8VC UT WOS:000340882200002 PM 24759775 ER PT J AU Lind, JN Perrine, CG Li, RW AF Lind, Jennifer N. Perrine, Cria G. Li, Ruowei TI Relationship between Use of Labor Pain Medications and Delayed Onset of Lactation SO JOURNAL OF HUMAN LACTATION LA English DT Article DE breastfeeding; lactation; labor and delivery; medication; risk factors ID EPIDURAL ANALGESIA; LACTOGENESIS II; RISK-FACTORS; DELIVERY; BEHAVIOR; SUCCESS AB Background: Despite estimates that 83% of mothers in the United States receive labor pain medications, little research has been done on how use of these medications affect onset of lactation. Objective: To investigate whether use of labor pain medications is associated with delayed onset of lactation (DOL). Methods: We analyzed data from the 2005-2007 Infant Feeding Practices Study II, a longitudinal study of women from late pregnancy through the entire first year after birth (n = 2366). In multivariable logistic regression analyses, we assessed the relationship between mothers' use of labor pain medication/method and DOL (milk coming in > 3 days after delivery). Results: Overall, 23.4% of women in our sample experienced DOL. Compared with women who delivered vaginally and received no labor pain medication, women who received labor pain medications had a higher odds of experiencing DOL: vaginal with spinal/epidural only (aOR 2.05; 95% CI, 1.43-2.95), vaginal with spinal/epidural plus another medication (aOR 1.79; 95% CI, 1.16-2.76), vaginal with other labor pain medications only ([not spinal/epidural]; aOR 1.84; 95% CI, 1.14-2.98), planned cesarean section with spinal/epidural only (aOR 2.13; 95% CI, 1.39-3.27), planned cesarean with spinal/epidural plus another medication (aOR 2.67; 95% CI, 1.35-5.29), emergency cesarean with spinal/epidural only (aOR 2.17; 95% CI, 1.34-3.51), and emergency cesarean with spinal/epidural plus another medication (aOR 3.03; 95% CI, 1.77-5.18). Conclusion: Mothers who received labor pain medications were more likely to report DOL, regardless of delivery method. This information could help inform clinical decisions regarding labor/delivery. C1 [Lind, Jennifer N.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Div Sci Educ & Profess Dev, Atlanta, GA USA. [Lind, Jennifer N.; Perrine, Cria G.; Li, Ruowei] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA USA. [Lind, Jennifer N.; Perrine, Cria G.] US Publ Hlth Serv Commissioned Corps, Atlanta, GA USA. RP Lind, JN (reprint author), CDC, Div Nutr Phys Act & Obes, 4770 Buford Hwy NE,MS F-77, Atlanta, GA 30341 USA. EM vox2@cdc.gov FU Intramural CDC HHS [CC999999]; NIDDK NIH HHS [T32 DK007734] NR 29 TC 1 Z9 2 U1 1 U2 15 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0890-3344 EI 1552-5732 J9 J HUM LACT JI J. Hum. Lact. PD MAY PY 2014 VL 30 IS 2 BP 167 EP 173 DI 10.1177/0890334413520189 PG 7 WC Nursing; Obstetrics & Gynecology; Pediatrics SC Nursing; Obstetrics & Gynecology; Pediatrics GA AN2NM UT WOS:000340422500008 PM 24451212 ER PT J AU Kay, MC Carroll, DD Carlson, SA Fulton, JE AF Kay, Melissa C. Carroll, Dianna D. Carlson, Susan A. Fulton, Janet E. TI Awareness and Knowledge of the 2008 Physical Activity Guidelines for Americans SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH LA English DT Article DE sedentary lifestyle; exercise; health promotion; physical fitness ID PUBLIC-HEALTH; HEART-ASSOCIATION; SPORTS-MEDICINE; MENTAL-HEALTH; ADULTS; RECOMMENDATIONS; EXERCISE; CAMPAIGNS; COLLEGE AB Background: To estimate the proportion of U.S. adults aware and knowledgeable of the 2008 Physical Activity Guidelines for Americans. Methods: Analysis is based on a cross-sectional national sample of adults in the 2009 (n = 4281) HealthStyles survey. We estimated the prevalence of adults who reported awareness of government physical activity guidelines and who were knowledgeable of the currently recommended moderate-intensity physical activity guideline (ie, 150 minutes per week) from the 2008 Guidelines. Results: In 2009, the percent of adults who reported being aware of government physical activity (PA) guidelines was 36.1%. The percent of adults knowledgeable of the moderate-intensity physical activity guideline was less than 1% (0.56%). Conclusions: Most U.S. adults lack sufficient awareness and knowledge of the 2008 Guidelines, putting them at risk for failure to meet them. The nation needs more effective communication strategies to translate and disseminate PA guidelines. C1 [Kay, Melissa C.] Ctr Dis Control & Prevent, Publ Hlth Prevent Serv, Div Leadership & Practice, Sci Educ & Profess Dev Program Off,Off Surveillan, Atlanta, GA 30333 USA. [Carroll, Dianna D.; Carlson, Susan A.; Fulton, Janet E.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA USA. [Carroll, Dianna D.] Commissioned Corps, Rockville, MD USA. RP Kay, MC (reprint author), Ctr Dis Control & Prevent, Publ Hlth Prevent Serv, Div Leadership & Practice, Sci Educ & Profess Dev Program Off,Off Surveillan, Atlanta, GA 30333 USA. NR 34 TC 11 Z9 11 U1 2 U2 8 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1543-3080 EI 1543-5474 J9 J PHYS ACT HEALTH JI J. Phys. Act. Health PD MAY PY 2014 VL 11 IS 4 BP 693 EP 698 DI 10.1123/jpah.2012-0171 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AM6OM UT WOS:000339984500003 PM 23493071 ER PT J AU Demissie, Z Lowry, R Eaton, DK Hertz, MF Lee, SM AF Demissie, Zewditu Lowry, Richard Eaton, Danice K. Hertz, Marci F. Lee, Sarah M. TI Associations of School Violence With Physical Activity Among US High School Students SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH LA English DT Article DE adolescent; bullying; safety; sedentary lifestyle ID HEALTH-RISK BEHAVIORS; BODY-MASS INDEX; SPORTS PARTICIPATION; SEDENTARY BEHAVIOR; GENDER-DIFFERENCES; YOUTH; ADOLESCENTS; POPULATION; PREVENTION; CHILDREN AB Background: This study investigated associations of violence-related behaviors with physical activity (PA)-related behaviors among U.S. high school students. Methods: Data from the 2009 national Youth Risk Behavior Survey, a cross-sectional survey of a nationally representative sample of 9th-12th grade students, were analyzed. Sex-stratified, adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated for associations between violence-related behaviors and being physically active for >= 60 minutes daily, sports participation, TV watching for >= 3 hours/day, and video game/computer use for >= 3 hours/day. Results: Among male students, at-school bullying victimization was negatively associated with daily PA (aOR: 0.72; 95% CI: 0.58-0.87) and sports participation; skipping school because of safety concerns was positively associated with video game/computer use (1.42; 1.01-2.00); and physical fighting was positively associated with daily PA. Among female students, at-school bullying victimization and skipping school because of safety concerns were both positively associated with video game/computer use (1.46; 1.19-1.79 and 1.60; 1.09-2.34, respectively), and physical fighting at school was negatively associated with sports participation and positively associated with TV watching. Conclusions: Bullying victimization emerged as a potentially important risk factor for insufficient PA. Schools should consider the role of violence in initiatives designed to promote PA. C1 [Demissie, Zewditu; Lowry, Richard; Eaton, Danice K.] Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, Atlanta, GA 30333 USA. [Hertz, Marci F.] Ctr Dis Control & Prevent, Div Violence Prevent, Atlanta, GA USA. [Lee, Sarah M.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Demissie, Z (reprint author), Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, Atlanta, GA 30333 USA. NR 45 TC 2 Z9 2 U1 1 U2 8 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1543-3080 EI 1543-5474 J9 J PHYS ACT HEALTH JI J. Phys. Act. Health PD MAY PY 2014 VL 11 IS 4 BP 705 EP 711 DI 10.1123/jpah.2012-0191 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AM6OM UT WOS:000339984500005 PM 25078515 ER PT J AU Pham, CD Ahn, S Turner, LA Wohrle, R Lockhart, SR AF Pham, Cau D. Ahn, Stacey Turner, Lance A. Wohrle, Ron Lockhart, Shawn R. TI Development and validation of benomyl birdseed agar for the isolation of Cryptococcus neoformans and Cryptococcus gattii from environmental samples SO MEDICAL MYCOLOGY LA English DT Article DE Cryptococcus gattii; Cryptococcus neoformans; benomyl; birdseed agar ID BRITISH-COLUMBIA; PACIFIC-NORTHWEST; UNITED-STATES; MELANIN PRODUCTION; VANCOUVER-ISLAND; CR-NEOFORMANS; SEED AGAR; CANADA; MEDIA; IDENTIFICATION AB One of the difficulties of isolating Cryptococcus neoformans and Cryptococcus gattii from environmental samples is the abundant overgrowth of other yeast and mold species that occurs on the plates. Here we report the application of benomyl to Guizotia abyssinica seed extract growth medium to improve the isolation of C. neoformans and C. gattii from environmental samples. We validated this medium by recovering C. neoformans and C. gattii from convenience soils and swabs from a region of the United States where these yeasts are endemic. C1 [Pham, Cau D.; Ahn, Stacey; Turner, Lance A.; Lockhart, Shawn R.] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA 30333 USA. [Wohrle, Ron] Washington State Dept Hlth, Tumwater, WA USA. RP Lockhart, SR (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,Mailstop G-11, Atlanta, GA 30333 USA. EM gyi2@cdc.gov NR 28 TC 0 Z9 0 U1 0 U2 2 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1369-3786 EI 1460-2709 J9 MED MYCOL JI Med. Mycol. PD MAY PY 2014 VL 52 IS 4 BP 417 EP 421 DI 10.1093/mmy/myt028 PG 5 WC Infectious Diseases; Mycology; Veterinary Sciences SC Infectious Diseases; Mycology; Veterinary Sciences GA AM5PX UT WOS:000339913600012 PM 24782104 ER PT J AU Frederick, GM Watson, KB Harris, CD Carlson, SA Fulton, JE AF Frederick, Ginny M. Watson, Kathleen B. Harris, Carmen D. Carlson, Susan A. Fulton, Janet E. TI US Adults' Participation in Specific Activities, Behavioral Risk Factor Surveillance System, 2011 SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [Frederick, Ginny M.; Watson, Kathleen B.; Harris, Carmen D.; Carlson, Susan A.; Fulton, Janet E.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 1204 BP 302 EP 302 PG 1 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115902061 ER PT J AU Garber, MD Lobelo, F Sajuria, M AF Garber, Michael D. Lobelo, Felipe Sajuria, Marcelo TI Nationally Representative Estimates of Health-Related Physical Fitness in Chilean 8th Graders SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [Garber, Michael D.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Lobelo, Felipe] Ctr Dis Control & Prevent, Atlanta, GA USA. [Sajuria, Marcelo] Inst Nacl Deportes Chile, Santiago, Chile. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 1210 BP 303 EP 304 PG 2 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115902067 ER PT J AU Soares, J Caspersen, CJ McMurray, RG McCurdy, TR AF Soares, Jesus Caspersen, Carl J. McMurray, Robert G. McCurdy, Thomas R. TI Resting Metabolic Rate and Percent Body Fat in Healthy Adult Men and Women SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [Soares, Jesus; Caspersen, Carl J.] Ctr Dis Control & Prevent, Atlanta, GA USA. [McMurray, Robert G.] Univ N Carolina, Chapel Hill, NC USA. [McCurdy, Thomas R.] US EPA, Res Triangle Pk, NC 27711 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 1823 BP 490 EP 491 PG 2 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115903184 ER PT J AU Dai, SF Carroll, DD Watson, KB Paul, P Carlson, SA Fulton, JE AF Dai, Shifan Carroll, Dianna D. Watson, Kathleen B. Paul, Prabasaj Carlson, Susan A. Fulton, Janet E. TI Participation In Specific Types Of Physical Activity Among US Adults, NHANES 1999-2006 SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [Dai, Shifan; Carroll, Dianna D.; Watson, Kathleen B.; Paul, Prabasaj; Carlson, Susan A.; Fulton, Janet E.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 2412 BP 649 EP 650 PG 2 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115904217 ER PT J AU Sloan, ML Carroll, DD Brown, DR AF Sloan, Michelle L. Carroll, Dianna D. Brown, David R. TI Physical Activity Among US Adults With And Without Mobility Disability, Nhanes 1999-2006 SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 61st Annual Meeting of the American-College-of-Sports-Medicine CY APR 01-04, 2014 CL Atlanta, GA SP Amer Coll Sports Med C1 [Sloan, Michelle L.; Carroll, Dianna D.; Brown, David R.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2014 VL 46 IS 5 SU 1 MA 2413 BP 650 EP 650 PG 1 WC Sport Sciences SC Sport Sciences GA AL4PW UT WOS:000339115904218 ER PT J AU Githuka, G Hladik, W Mwalili, S Cherutich, P Muthui, M Gitonga, J Maina, WK Kim, AA AF Githuka, George Hladik, Wolfgang Mwalili, Samuel Cherutich, Peter Muthui, Mercy Gitonga, Joshua Maina, William K. Kim, Andrea A. CA KAIS Study Grp TI Populations at Increased Risk for HIV Infection in Kenya: Results From a National Population-Based Household Survey, 2012 SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE high-risk populations; HIV; men who have sex with men; transactional sex; anal intercourse; Kenya ID MIDDLE-INCOME COUNTRIES; HUMAN-IMMUNODEFICIENCY-VIRUS; SEX; MEN; WOMEN AB Background: Populations with higher risks for HIV exposure contribute to the HIV epidemic in Kenya. We present data from the second Kenya AIDS Indicator Survey to estimate the size and HIV prevalence of populations with high-risk characteristics. Methods: The Kenya AIDS Indicator Survey 2012 was a national survey of Kenyans aged 18 months to 64 years which linked demographic and behavioral information with HIV results. Data were weighted to account for sampling probability. This analysis was restricted to adults aged 18 years and older. Results: Of 5088 men and 6745 women, 0.1% [95% confidence interval (CI): 0.03 to 0.14] were persons who inject drugs (PWID). Among men, 0.6% (CI: 0.3 to 0.8) had ever had sex with other men, and 3.1% (CI: 2.4 to 3.7) were males who had ever engaged in transactional sex work (MTSW). Among women, 1.9% (CI: 1.3 to 2.5) had ever had anal sex, and 4.1% (CI: 3.5 to 4.8) were women who had ever engaged in transactional sex work (FTSW). Among men, 17.6% (CI: 15.7 to 19.6) had been male clients of transactional sex workers (TSW). HIV prevalence was 0% among men who have sex with men, 6.3% (CI: 0 to 18.1) among persons who injected drugs, 7.1% (CI: 4.8 to 9.4) among male clients of TSW, 7.6% (CI: 1.8 to 13.4) among MTSW, 12.1% (CI: 7.1 to 17.1) among FTSW, and 12.1% (CI: 5.0 to 19.2) among females who ever had engaged in anal sex. Conclusions: Population-based data on high-risk populations can be used to set realistic targets for HIV prevention, care, and treatment for these groups. These data should inform priorities for high-risk populations in the upcoming Kenyan strategic plan on HIV/AIDS. C1 [Githuka, George; Cherutich, Peter; Maina, William K.] Minist Hlth, Natl AIDS & Sexually Transmitted Infect Control S, Nairobi, Kenya. [Hladik, Wolfgang] US Ctr Dis Control & Prevent, Div Global HIV AIDS, Ctr Global Hlth, Atlanta, GA USA. [Mwalili, Samuel; Muthui, Mercy; Kim, Andrea A.] US Ctr Dis Control & Prevent, Div Global HIV AIDS, Ctr Global Hlth, Nairobi, Kenya. [Gitonga, Joshua] Natl AIDS Control Council, Nairobi, Kenya. RP Githuka, G (reprint author), Kenyatta Hosp Grounds, Natl AIDS & STI Control Programme, Off Hosp Rd,POB 19361-00202, Nairobi, Kenya. EM ggithuka@nascop.or.ke FU National AIDS and STI Control Programme (NASCOP); Kenya National Bureau of Statistics (KNBS); National Public Health Laboratory Services (NPHLS); National AIDS Control Council (NACC); National Council for Population and Development (NCPD); Kenya Medical Research Institute (KEMRI); US Centers for Disease Control and Prevention (CDC/Kenya); US Centers for Disease Control and Prevention (CDC/Atlanta); United States Agency for International Development (USAID/Kenya); University of California, San Francisco (UCSF); Joint United Nations Team on HIV/AIDS; Japan International Cooperation Agency (JICA); Elizabeth Glaser Paediatric AIDS Foundation (EGPAF); Liverpool Voluntary Counselling and Testing (LVCT); African Medical and Research Foundation (AMREF); World Bank; Global Fund; US President's Emergency Plan for AIDS Relief through US Centers for Disease Control and Prevention, Division of Global HIV/AIDS [PS001805, GH,000069, PS001814]; Joint United Nations Team for HIV/AIDS FX Kenya AIDS Indicator Survey (KAIS) 2012 was supported by the National AIDS and STI Control Programme (NASCOP), Kenya National Bureau of Statistics (KNBS), National Public Health Laboratory Services (NPHLS), National AIDS Control Council (NACC), National Council for Population and Development (NCPD), Kenya Medical Research Institute (KEMRI), US Centers for Disease Control and Prevention (CDC/Kenya, CDC/Atlanta), United States Agency for International Development (USAID/Kenya), University of California, San Francisco (UCSF), Joint United Nations Team on HIV/AIDS, Japan International Cooperation Agency (JICA), Elizabeth Glaser Paediatric AIDS Foundation (EGPAF), Liverpool Voluntary Counselling and Testing (LVCT), African Medical and Research Foundation (AMREF), World Bank, and Global Fund. This publication was made possible by support from the US President's Emergency Plan for AIDS Relief through cooperative agreements (#PS001805, GH,000069, and PS001814) from the US Centers for Disease Control and Prevention, Division of Global HIV/AIDS. This work was also funded in part by support from the Global Fund, World Bank, and the Joint United Nations Team for HIV/AIDS. NR 26 TC 6 Z9 6 U1 4 U2 11 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD MAY 1 PY 2014 VL 66 SU 1 BP S46 EP S56 PG 11 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AL3LO UT WOS:000339029600006 PM 24732821 ER PT J AU Lanzieri, TM Bialek, SR Bennett, MV Gould, JB AF Lanzieri, Tatiana M. Bialek, Stephanie R. Bennett, Mihoko V. Gould, Jeffrey B. TI Cytomegalovirus infection among infants in California neonatal intensive care units, 2005-2010 SO JOURNAL OF PERINATAL MEDICINE LA English DT Article DE Acquired infection; congenital infection; cytomegalovirus; premature infant; prevalence; very low birth weight infant ID BREAST-MILK; GANCICLOVIR THERAPY; PREMATURE-INFANTS; PRETERM INFANTS; TRANSMISSION; DISEASE; PREVALENCE; MORTALITY; PREGNANCY; DIAGNOSIS AB Aim: To assess the burden of congenital and perinatal cytomegalovirus (CMV) disease among infants hospitalized in neonatal intensive care units (NICUs). Methods: CMV infection was defined as a report of positive CMV viral culture or polymerase chain reaction at any time since birth in an infant hospitalized in a NICU reporting to California Perinatal Quality Care Collaborative during 2005-2010. Results: One hundred and fifty-six (1.7 per 1000) infants were reported with CMV infection, representing an estimated 5% of the expected number of live births with symptomatic CMV disease. Prevalence was higher among infants with younger gestational ages and lower birth weights. Infants with CMV infection had significantly longer hospital stays and 14 (9%) died. Conclusions: Reported prevalence of CMV infection in NICUs represents a fraction of total expected disease burden from CMV in the newborn period, likely resulting from underdiagnosis and milder symptomatic cases that do not require NICU care. More complete ascertainment of infants with congenital CMV infection that would benefit from antiviral treatment may reduce the burden of CMV disease in this population. C1 [Lanzieri, Tatiana M.] Natl Ctr Immunizat & Resp Dis, Ctr Dis Control & Prevent, Atlanta, GA USA. [Bialek, Stephanie R.] CDC, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Bennett, Mihoko V.; Gould, Jeffrey B.] CPQCC, Stanford, CA USA. [Bennett, Mihoko V.; Gould, Jeffrey B.] Stanford Univ, Sch Med, Stanford, CA 94305 USA. RP Lanzieri, TM (reprint author), Natl Ctr Immunizat & Resp Dis, Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mail Stop A-34, Atlanta, GA USA. EM tmlanzieri@cdc.gov FU Intramural CDC HHS [CC999999] NR 35 TC 1 Z9 1 U1 0 U2 3 PU WALTER DE GRUYTER GMBH PI BERLIN PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY SN 0300-5577 EI 1619-3997 J9 J PERINAT MED JI J. Perinat. Med. PD MAY PY 2014 VL 42 IS 3 BP 393 EP 399 DI 10.1515/jpm-2013-0183 PG 7 WC Obstetrics & Gynecology; Pediatrics SC Obstetrics & Gynecology; Pediatrics GA AL2CX UT WOS:000338934600018 PM 24334425 ER PT J AU Paulozzi, LJ Zhang, K Jones, CM Mack, KA AF Paulozzi, Leonard J. Zhang, Kun Jones, Christopher M. Mack, Karin A. TI Risk of Adverse Health Outcomes with Increasing Duration and Regularity of Opioid Therapy SO JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE LA English DT Article DE Analgesics; Drug Abuse; Pain Management; Poisoning ID CHRONIC NONCANCER PAIN; UNITED-STATES; DRUG OVERDOSE; PRESCRIPTIONS; ASSOCIATION; POPULATION; PREVALENCE; DISORDERS; PATTERNS; ABUSE AB Purpose: The purpose of this study was to examine trends in frequency and daily dosage of opioid use and related adverse health outcomes in a commercially insured population. Methods: We examined medical claims from the Truven Health MarketScan commercial claims database for 789,457 continuously enrolled patients ages 18 to 64 years to whom opioids were dispensed during the first half of 2008. We tracked them every 6 months until either opioid use was discontinued or the end of 2010. We compared outcomes among all opioid users with those for patients who used opioids with only limited interruptions during the index period, referred to as "daily users." We contrasted the experience of daily users, other users, and nonusers for various outcomes. Results: Of all claimants, 10.7% had at least one opioid prescription during the first 6 months of 2008. Of these, 39.9% continued through a second 6-month period, and 18.0% continued through the end of 2010. Only 9.0% of all users qualified as daily users, but 87.1% of them continued some use of opioids through the end of 2010. Only 43.8% of all users who continued use through 2010 initially qualified as daily users. Among all users who continued use through 2010, days of use and daily dosage increased with duration of use. Among daily users, only dosage increased, rising from 101 to 114 morphine milligram equivalents/day over the 3 years. The prevalence of benzodiazepine use was greater for daily than all users, exceeding 40% among daily users who continued opioid use for 3 years. Drug abuse and overdose rates increased with longer use. Daily users accounted for 25.0%, other users for 43.6%, and nonusers for 31.4% of opioid analgesic overdoses. Conclusions: Adverse health outcomes can increase with accumulating opioid use and increasing dosage. Existing guidelines developed by specialty societies for managing patients using opioids daily or nearly daily do not address the larger number of patients who use opioids intermittently over periods of years. Practitioners should consider applying such guidelines to patients who use opioids less frequently. C1 [Paulozzi, Leonard J.; Zhang, Kun; Jones, Christopher M.; Mack, Karin A.] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Div Unintent Injury Prevent, Atlanta, GA USA. RP Paulozzi, LJ (reprint author), El Paso Quarantine Stn, 601 Sunland Pk Dr,Suite 200, El Paso, TX 79912 USA. EM lbp4@cdc.gov RI Mack, Karin/A-3263-2012 OI Mack, Karin/0000-0001-9274-3001 FU Centers for Disease Control and Prevention FX All work for this manuscript was funded by the Centers for Disease Control and Prevention. NR 46 TC 22 Z9 23 U1 1 U2 3 PU AMER BOARD FAMILY MEDICINE PI LEXINGTON PA 2228 YOUNG DR, LEXINGTON, KY 40505 USA SN 1557-2625 EI 1558-7118 J9 J AM BOARD FAM MED JI J. Am. Board Fam. Med. PD MAY-JUN PY 2014 VL 27 IS 3 BP 329 EP 338 DI 10.3122/jabfm.2014.03.130290 PG 10 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA AL5IL UT WOS:000339167000007 PM 24808111 ER PT J AU Sutton, MY Frazier, E Short, W Skarbinski, J AF Sutton, Madeline Y. Frazier, Emma Short, William Skarbinski, Jacek TI Pregnancies Among Reproductive-Aged Human Immunodeficiency Virus-Infected Women in Care, United States SO OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 62nd Annual Clinical Meeting of the American-College-of-Obstetricians-and-Gynecologists CY APR 26-30, 2014 CL Chicago, IL SP Amer Coll Obstetricians & Gynecologists C1 [Sutton, Madeline Y.; Frazier, Emma; Short, William; Skarbinski, Jacek] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 EI 1873-233X J9 OBSTET GYNECOL JI Obstet. Gynecol. PD MAY PY 2014 VL 123 SU 1 BP 33S EP 34S PG 2 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA AL4CG UT WOS:000339079900069 PM 24770169 ER PT J AU Ershova, JV Podewils, LJ Bronner, LE Stockwell, HG Dlamini, S Mametja, LD AF Ershova, J. V. Podewils, L. J. Bronner, L. E. Stockwell, H. G. Dlamini, S. Mametja, L. D. TI Evaluation of adherence to national treatment guidelines among tuberculosis patients in three provinces of South Africa SO SAMJ SOUTH AFRICAN MEDICAL JOURNAL LA English DT Article ID DIRECTLY OBSERVED THERAPY; ANTITUBERCULOSIS DRUGS; TB; PREVALENCE; KNOWLEDGE AB Background. Standardised tuberculosis (TB) treatment through directly observed therapy (DOT) is available in South Africa, but the level of adherence to standardised TB treatment and its impact on treatment outcomes is unknown. Objectives. To describe adherence to standardised TB treatment and provision of DOT, and analyse its impact on treatment outcome. Methods. We utilised data collected for an evaluation of the South African national TB surveillance system. A treatment regimen was considered appropriate if based on national treatment guidelines. Multivariate log-binomial regression was used to evaluate the association between treatment regimens, including DOT provision, and treatment outcome. Results. Of 1 339 TB cases in the parent evaluation, 598 (44.7%) were excluded from analysis owing to missing outcome or treatment information. The majority (697, 94.1%) of the remaining 741 patients received an appropriate TB regimen. Almost all patients (717, 96.8%) received DOT, 443 (59.8%) throughout the treatment course and 274 (37.0%) during the intensive (256, 34.6%) or continuation (18, 2.4%) phase. Independent predictors of poor outcome were partial DOT (adjusted risk ratio (aRR) 3.1, 95% confidence interval (CI) 2.2 - 4.3) and previous treatment default (aRR 2.3, 95% CI 1.1 - 4.8). Conclusion. Patients who received incomplete DOT or had a history of defaulting from TB treatment had an increased risk of poor outcomes. C1 [Ershova, J. V.; Podewils, L. J.; Bronner, L. E.] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA. [Ershova, J. V.; Stockwell, H. G.] Univ S Florida, Coll Publ Hlth, Tampa, FL USA. [Dlamini, S.; Mametja, L. D.] Natl Dept Hlth, Pretoria, South Africa. RP Ershova, JV (reprint author), Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA. EM jhe3@cdc.gov FU Intramural CDC HHS [CC999999] NR 16 TC 1 Z9 2 U1 0 U2 6 PU SA MEDICAL ASSOC PI PRETORIA PA BLOCK F CASTLE WALK CORPORATE PARK, NOSSOB STREET, ERASMUSKLOOF EXT3, PRETORIA, 0002, SOUTH AFRICA SN 0256-9574 EI 2078-5135 J9 SAMJ S AFR MED J JI SAMJ S. Afr. Med. J. PD MAY PY 2014 VL 104 IS 5 BP 362 EP U3368 DI 10.7196/SAMJ.7655 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AL8KI UT WOS:000339386900025 PM 25212205 ER PT J AU Korrick, S Chen, C Schantz, S Calafat, A AF Korrick, S. Chen, C. Schantz, S. Calafat, A. TI The impact of adolescent exposure to bisphenol A (BPA) and phthalates on neurobehavior: A pilot epidemiologic study SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Meeting Abstract CT 38th Annual Meeting of the Neurobehavioral-Teratology-Society CY JUN 28-JUL 02, 2014 CL Bellevue, WA SP Neurobehavioral Teratol Soc C1 [Korrick, S.; Chen, C.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Channing Div Network Med, Boston, MA 02115 USA. [Korrick, S.] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. [Schantz, S.] Univ Illinois, Urbana, IL USA. [Calafat, A.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 1 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 EI 1872-9738 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD MAY-JUN PY 2014 VL 43 MA NBTS 05 BP 77 EP 77 DI 10.1016/j.ntt.2014.04.008 PG 1 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA AK7QC UT WOS:000338621800015 ER PT J AU Baldwin, LM Trivers, KF Andrilla, CHA Matthews, B Miller, JW Lishner, DM Goff, BA AF Baldwin, Laura-Mae Trivers, Katrina F. Andrilla, C. Holly A. Matthews, Barbara Miller, Jacqueline W. Lishner, Denise M. Goff, Barbara A. TI Accuracy of Ovarian and Colon Cancer Risk Assessments by U.S. Physicians SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Article DE cancer; quality of care; risk estimation ID PRIMARY-CARE PHYSICIANS; FORCE RECOMMENDATION STATEMENT; BREAST-CANCER; FAMILY-HISTORY; COLORECTAL-CANCER; TRANSVAGINAL ULTRASOUND; MUTATION CARRIERS; RANDOMIZED-TRIAL; US PHYSICIANS; WOMEN AB BACKGROUND: Studies have shown a mismatch between published cancer screening and genetic counseling referral recommendations and physician-reported screening and referral practices. Inaccurate cancer risk assessment is one potential cause of this mismatch. OBJECTIVE: To assess U.S. physicians' ability to accurately determine a woman's colon and ovarian cancer risk level. DESIGN, PARTICIPANTS: Cross-sectional survey of U.S. family physicians, general internists, and obstetrician-gynecologists. A twelve-page questionnaire with a vignette of a woman's annual examination included a question about the patient's level of colon and ovarian cancer risk. The final study sample included 1,555 physicians weighted to represent practicing U.S. physicians nationally. MAIN MEASURE: Accuracy of physicians' ovarian and colon cancer risk assessments. KEY RESULTS: Overall, most physicians accurately assessed women's risk of ovarian (57.0 %, CI 54.3, 59.6) and colon cancer (62.0 %, CI 59.4, 64.6). However, 27.1 % (CI 23.0, 31.6) of physicians overestimated the ovarian cancer risk among women at the same risk as the general population, and 65.1 % (CI 60.2, 69.7) underestimated ovarian cancer risk among women at much higher risk than the general population. Physicians overestimated colon more than ovarian cancer risk (38.0 %, CI 35.4, 40.6 vs. 27.1 %, CI 23.0, 31.6) for women at the same risk as the general population. CONCLUSIONS: Physicians' misestimation of patient ovarian and colon cancer risk may put average risk patients in jeopardy of unnecessary screening and higher risk patients in jeopardy of missed opportunities for prevention or early detection of cancers. C1 [Baldwin, Laura-Mae; Andrilla, C. Holly A.; Matthews, Barbara; Lishner, Denise M.] Univ Washington, Dept Family Med, Seattle, WA 98195 USA. [Trivers, Katrina F.; Miller, Jacqueline W.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA USA. [Goff, Barbara A.] Univ Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA. RP Baldwin, LM (reprint author), Univ Washington, Dept Family Med, Box 354982, Seattle, WA 98195 USA. EM lmb@uw.edu FU Centers for Disease Control and Prevention (CDC) through the University of Washington Health Promotion Research Centers Cooperative Agreement [U48DP001911]; Alliance for Reducing Cancer, Northwest (ARC NW); Centers for Disease Control and Prevention (CDC) [U48DP001911]; National Cancer Institute (NCI) FX This project was funded by the Centers for Disease Control and Prevention (CDC) through the University of Washington Health Promotion Research Centers Cooperative Agreement U48DP001911, and through the Alliance for Reducing Cancer, Northwest (ARC NW), funded by both the Centers for Disease Control and Prevention (CDC; Grant U48DP001911, V. Taylor, PI) and the National Cancer Institute (NCI). The findings and conclusions of this journal article are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 69 TC 3 Z9 3 U1 0 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD MAY PY 2014 VL 29 IS 5 BP 741 EP 749 DI 10.1007/s11606-014-2768-2 PG 9 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA AK1VL UT WOS:000338205700014 PM 24519100 ER PT J AU Noh, J Rodriguez, S Lee, YM Handali, S Gonzalez, AE Gilman, RH Tsang, VCW Garcia, HH Wilkins, PP AF Noh, John Rodriguez, Silvia Lee, Yeuk-Mui Handali, Sukwan Gonzalez, Armando E. Gilman, Robert H. Tsang, Victor C. W. Garcia, Hector H. Wilkins, Patricia P. TI Recombinant Protein- and Synthetic Peptide-Based Immunoblot Test for Diagnosis of Neurocysticercosis SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID LINKED IMMUNOELECTROTRANSFER BLOT; TAENIA-SOLIUM CYSTICERCOSIS; IMMUNOSORBENT-ASSAY; ANTIGENS; CLONING; SERODIAGNOSIS; ANTIBODIES; MANAGEMENT; AGREEMENT; CRITERIA AB One of the most well-characterized tests for diagnosing neurocysticercosis (NCC) is the enzyme-linked immunoelectrotransfer blot (EITB) assay developed at the CDC, which uses lentil lectin-bound glycoproteins (LLGP) extracted from Taenia solium cysticerci. Although the test is very reliable, the purification process for the LLGP antigens has been difficult to transfer to other laboratories because of the need for expensive equipment and technical expertise. To develop a simpler assay, we previously purified and cloned the diagnostic glycoproteins in the LLGP fraction. In this study, we evaluated three representative recombinant or synthetic antigens from the LLGP fraction, individually and in different combinations, using an immunoblot assay (recombinant EITB). Using a panel of 249 confirmed NCC-positive and 401 negative blood serum samples, the sensitivity of the recombinant EITB assay was determined to be 99% and the specificity was 99% for diagnosing NCC. We also tested a panel of 239 confirmed NCC-positive serum samples in Lima, Peru, and found similar results. Overall, our data show that the performance characteristics of the recombinant EITB assay are comparable to those of the LLGP-EITB assay. This new recombinant-and synthetic antigen-based assay is sustainable and can be easily transferred to other laboratories in the United States and throughout the world. C1 [Noh, John; Lee, Yeuk-Mui; Handali, Sukwan; Wilkins, Patricia P.] Ctr Dis Control & Prevent, Ctr Global Hlth, Div Parasit Dis & Malaria, Atlanta, GA 30333 USA. [Rodriguez, Silvia; Garcia, Hector H.] Inst Nacl Ciencias Neurol, Cysticercosis Unit, Lima, Peru. [Gonzalez, Armando E.; Gilman, Robert H.; Garcia, Hector H.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Gonzalez, Armando E.] Univ San Marcos, Sch Vet Med, Lima, Peru. [Tsang, Victor C. W.] Georgia State Univ, Dept Biol, Atlanta, GA 30303 USA. [Garcia, Hector H.] Univ Peruana Cayetano Heredia, Dept Microbiol, Lima, Peru. [Garcia, Hector H.] Univ Peruana Cayetano Heredia, Ctr Global Hlth, Lima, Peru. RP Noh, J (reprint author), Ctr Dis Control & Prevent, Ctr Global Hlth, Div Parasit Dis & Malaria, Atlanta, GA 30333 USA. EM jnoh@cdc.gov FU Fogarty International Center/NIH [D43 TW001140]; Bill and Melinda Gates Foundation [23981]; Epilepsy Program, National Center for Chronic Disease Prevention and Health Promotion, CDC; Wellcome Trust Senior International Research Fellowship in public health and tropical medicine FX This work was supported in part by the Fogarty International Center/NIH (training grant D43 TW001140), the Bill and Melinda Gates Foundation (grant 23981), and the Epilepsy Program, National Center for Chronic Disease Prevention and Health Promotion, CDC. H.H.G. is supported by a Wellcome Trust Senior International Research Fellowship in public health and tropical medicine. The funders had no role in the study design, data collection, analysis, or interpretation, in writing the manuscript, or in the decision to submit the article for publication. NR 33 TC 5 Z9 6 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAY PY 2014 VL 52 IS 5 BP 1429 EP 1434 DI 10.1128/JCM.03260-13 PG 6 WC Microbiology SC Microbiology GA AJ7XV UT WOS:000337915700018 PM 24554747 ER PT J AU Liu, H Taylor, TH Pettus, K Trees, D AF Liu, Hsi Taylor, Thomas H., Jr. Pettus, Kevin Trees, David TI Assessment of Etest as an Alternative to Agar Dilution for Antimicrobial Susceptibility Testing of Neisseria gonorrhoeae SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID DISEASES-TREATMENT-GUIDELINES; GONOCOCCAL INFECTIONS; UNITED-STATES; NO LONGER; RESISTANCE; CEPHALOSPORINS; BACTERIA; UPDATE AB We studied whether the Etest can be used as an alternative to agar dilution to determine antimicrobial susceptibilities of ceftriaxone, cefixime, and cefpodoxime in Neisseria gonorrhoeae surveillance. One hundred fifteen clinical and laboratory isolates of N. gonorrhoeae were tested following the Clinical Laboratory Improvement Amendments (CLIA)-approved CLSI standard agar dilution method and, separately, by the Etest according to the manufacturer's recommendations. The MICs were determined and compared. Ten laboratory-generated mutants were used to simulate substantially nonsusceptible specimens. The Etest and agar dilution methods were well correlated. Statistical tests produced regression R-2 values of 88%, 82%, and 85% and Pearson correlation coefficients of 92%, 91%, and 92% for ceftriaxone, cefixime, and cefpodoxime, respectively. When paired comparisons were made, the two tests were 88.7%, 80%, and 87% within 1 log(2) dilution from each other for ceftriaxone, cefixime, and cefpodoxime, respectively. The within-2-log(2) agreements were 99.1%, 98.3%, and 94.8% for ceftriaxone, cefixime, and cefpodoxime, respectively. Notwithstanding the good correlations and the within-2-log(2) general agreement, the Etest results produced slightly lower MICs than the agar dilution results. In conclusion, we found that the Etest can be effectively used as an alternative to agar dilution testing to determine the susceptibility of N. gonorrhoeae to ceftriaxone, cefixime, and cefpodoxime, although we recommend further research into extremely resistant isolates. For isolates within the typical range of clinical MICs, reexamination of the Etest interpretation of susceptible and nonsusceptible categories would likely allow for successful transition from agar dilution to the Etest. C1 [Liu, Hsi; Pettus, Kevin; Trees, David] Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div Sexually Transmitted Dis Prevent, Atlanta, GA 30333 USA. [Liu, Hsi; Taylor, Thomas H., Jr.; Pettus, Kevin; Trees, David] Ctr Dis Control & Prevent, Atlanta, GA USA. [Taylor, Thomas H., Jr.] Natl Ctr Immunizat & Resp Dis, Div Bacterial Dis, Atlanta, GA USA. RP Liu, H (reprint author), Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div Sexually Transmitted Dis Prevent, Atlanta, GA 30333 USA. EM hcl6@cdc.gov NR 21 TC 3 Z9 3 U1 1 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAY PY 2014 VL 52 IS 5 BP 1435 EP 1440 DI 10.1128/JCM.02131-13 PG 6 WC Microbiology SC Microbiology GA AJ7XV UT WOS:000337915700019 PM 24554750 ER PT J AU Munoz-Jordan, JL Santiago, GA AF Munoz-Jordan, Jorge L. Santiago, Gilberto A. TI Inconclusive Reverse Transcription-PCR Assay Comparison for Dengue Virus Detection and Serotyping SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Letter ID TIME RT-PCR C1 [Munoz-Jordan, Jorge L.; Santiago, Gilberto A.] Ctr Dis Control & Prevent, Dengue Branch, Div Vector Borne Dis, San Juan, PR 00920 USA. RP Munoz-Jordan, JL (reprint author), Ctr Dis Control & Prevent, Dengue Branch, Div Vector Borne Dis, San Juan, PR 00920 USA. EM ckq2@cdc.gov NR 9 TC 3 Z9 3 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAY PY 2014 VL 52 IS 5 BP 1800 EP 1800 DI 10.1128/JCM.03420-13 PG 1 WC Microbiology SC Microbiology GA AJ7XV UT WOS:000337915700087 PM 24744402 ER PT J AU Johnson, BJB Pilgard, MA Russell, TM AF Johnson, Barbara J. B. Pilgard, Mark A. Russell, Theresa M. TI Reply to "No Evidence for Contamination of Borrelia Blood Cultures: a Review of Facts" SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Letter C1 [Johnson, Barbara J. B.; Pilgard, Mark A.; Russell, Theresa M.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. RP Johnson, BJB (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. EM BJohnson@cdc.gov NR 3 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAY PY 2014 VL 52 IS 5 BP 1804 EP 1804 DI 10.1128/JCM.00252-14 PG 1 WC Microbiology SC Microbiology GA AJ7XV UT WOS:000337915700090 PM 24744405 ER PT J AU Johnson, BJB Pilgard, MA Russell, TM AF Johnson, Barbara J. B. Pilgard, Mark A. Russell, Theresa M. TI Assessment of New Culture Method for Detection of Borrelia Species from Serum of Lyme Disease Patients (vol 52, pg 721, 2014) SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Correction C1 [Johnson, Barbara J. B.; Pilgard, Mark A.; Russell, Theresa M.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. RP Johnson, BJB (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. NR 1 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAY PY 2014 VL 52 IS 5 BP 1808 EP 1808 DI 10.1128/JCM.00504-14 PG 1 WC Microbiology SC Microbiology GA AJ7XV UT WOS:000337915700093 ER PT J AU Damon, IK Damaso, CR McFadden, G AF Damon, Inger K. Damaso, Clarissa R. McFadden, Grant TI Are We There Yet? The Smallpox Research Agenda Using Variola Virus SO PLOS PATHOGENS LA English DT Editorial Material ID MONKEYPOX; VACCINE; IMMUNOGENICITY; ORTHOPOXVIRUS; EFFICACY; SAFETY; ST-246; MOUSEPOX; CMX001 C1 [Damon, Inger K.] Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Dis, Atlanta, GA 30333 USA. [Damaso, Clarissa R.] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941 Rio De Janeiro, Brazil. [McFadden, Grant] Univ Florida, Dept Mol Genet & Microbiol, Coll Med, Gainesville, FL USA. RP Damon, IK (reprint author), Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Dis, Atlanta, GA 30333 USA. EM IDamon@cdc.gov NR 26 TC 4 Z9 4 U1 2 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7366 EI 1553-7374 J9 PLOS PATHOG JI PLoS Pathog. PD MAY PY 2014 VL 10 IS 5 AR e1004108 DI 10.1371/journal.ppat.1004108 PG 3 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA AJ5NX UT WOS:000337732300025 PM 24789223 ER PT J AU Vaz-de-Lima, LRA Martin, MD Pawloski, LC Leite, D Rocha, KCP de Brito, CA Vaz, TMI Martins, LM Alvarenga, DP Ribeiro, AF Carvalhanas, TRMP Nakasaki, RMD Oliveira, SS Waldman, EA Tondella, ML AF Vaz-de-Lima, Lourdes R. A. Martin, Monte D. Pawloski, Lucia C. Leite, Daniela Rocha, Karen C. P. de Brito, Cyro A. Vaz, Tania M. I. Martins, Luciano Moura Alvarenga, Danielly P. Ribeiro, Ana F. Carvalhanas, Telma R. M. P. Nakasaki, Rosa M. D. Oliveira, Silvia S. Waldman, Eliseu A. Tondella, Maria Lucia CA Clinical Epidemiological Team Work TI Serodiagnosis as Adjunct Assay for Pertussis Infection in Sao Paulo, Brazil SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID BORDETELLA-PERTUSSIS; UNITED-STATES; TOXIN; ANTIBODIES; VACCINATION; PREVENTION; DIPHTHERIA; DIAGNOSIS; OUTBREAK; FIMBRIAE AB Pertussis remains an important public health problem in many countries despite extensive immunization. Cultures and real-time PCR (RT-PCR) assays are the recommended pertussis diagnostic tests, but they lack sensitivity at the later stage of the disease. This study introduces the IgG anti-pertussis toxin enzyme-linked immunosorbent assay (PT ELISA) in our routine diagnosis to improve disease burden estimation. Serum samples and nasopharyngeal swabs (n = 503) were collected at the same time from patients presenting with cough illness suspected of being pertussis and tested by the PT ELISA and culture and/or RT-PCR, respectively. Patients were separated into three age groups: group 1,<1 year (n = 260; mean age, 3 months), group 2, 1 to 6 years (n = 81; mean age, 3 years), and group 3,>= 7 years (n = 162; mean age, 26 years). The times (means) from cough onset to specimen collection were 16, 24, and 26 days, respectively. In group 1, 83 (82.2%) of 101 positive cases were positive for pertussis by culture/RT-PCR, while 40 (39.6%) tested positive by PT ELISA. In group 2, 6 (19.4%) of 31 positive cases were culture/RT-PCR positive, and 29 (93.6%) were seropositive. In group 3, 13 (13.8%) of 94 positive cases were positive by culture/RT-PCR and 91 (96.8%) were positive by serology. Culture/RT-PCR detected more cases of pertussis in infants (P < 0.0001), whereas the PT ELISA detected more cases in adolescents and adults (P < 0.0001). The timing between cough onset and specimen collection or recent vaccination may have partially affected our results. Serology is a suitable, cost-effective, and complementary pertussis diagnostic tool, especially among older children, adolescents, and adults during the later disease phase. C1 [Vaz-de-Lima, Lourdes R. A.; Leite, Daniela; Rocha, Karen C. P.; de Brito, Cyro A.; Vaz, Tania M. I.; Martins, Luciano Moura; Alvarenga, Danielly P.] Adolfo Lutz Inst, Bacteriol Ctr, Ctr Immunol, Sao Paulo, Brazil. [Martin, Monte D.; Pawloski, Lucia C.; Tondella, Maria Lucia] Ctr Dis Control & Prevent, Div Bacterial Dis, NCIRD, Atlanta, GA USA. [Ribeiro, Ana F.; Carvalhanas, Telma R. M. P.] Secretaria Estado Saude Sao Paulo, Ctr Vigilancia Epidemiol, Resp Branch, Sao Paulo, Brazil. [Nakasaki, Rosa M. D.; Oliveira, Silvia S.] Secretaria Municipal Saude CCD COVISA, Ctr Controle Doencas, Coordenacao Vigilancia Saude, Sao Paulo, Brazil. [Waldman, Eliseu A.] Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, BR-09500900 Sao Paulo, Brazil. RP Vaz-de-Lima, LRA (reprint author), Adolfo Lutz Inst, Bacteriol Ctr, Ctr Immunol, Sao Paulo, Brazil. EM lourlima@uol.com.br RI Brito, Cyro/C-1910-2012 OI Brito, Cyro/0000-0002-9934-6102 FU Fogarty International Center Global Infectious Diseases Research Training Program grant, National Institutes of Health, University of Pittsburgh [D43TW006592]; Instituto Adolfo Lutz FX We thank GlaxoSmithKline for providing the purified pertussis toxin antigens used in this study and the Secretary of Health of Sao Paulo and Instituto Adolfo Lutz for support. We also thank Adele Caterino de Araujo and Suely S. Kashino for comments on and review of the manuscript.; This work was supported in part by a Fogarty International Center Global Infectious Diseases Research Training Program grant, National Institutes of Health, University of Pittsburgh (D43TW006592). NR 27 TC 1 Z9 3 U1 1 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 EI 1556-679X J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD MAY PY 2014 VL 21 IS 5 BP 636 EP 640 DI 10.1128/CVI.00760-13 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AJ0NU UT WOS:000337352300005 PM 24599531 ER PT J AU Isakova-Sivak, I Chen, LM Bourgeois, M Matsuoka, Y Voeten, JTM Heldens, JGM van den Bosch, H Klimov, A Rudenko, L Cox, NJ Donis, RO AF Isakova-Sivak, Irina Chen, Li-Mei Bourgeois, Melissa Matsuoka, Yumiko Voeten, J. Theo M. Heldens, Jacco G. M. van den Bosch, Han Klimov, Alexander Rudenko, Larisa Cox, Nancy J. Donis, Ruben O. TI Characterization of Reverse Genetics-Derived Cold-Adapted Master Donor Virus A/Leningrad/134/17/57 (H2N2) and Reassortants with H5N1 Surface Genes in a Mouse Model SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID INFLUENZA-A VIRUS; AVIAN-INFLUENZA; INACTIVATED VACCINES; IMMUNE-RESPONSES; HEALTHY-ADULTS; LIVE; INFECTION; IMMUNOGENICITY; PROTECTION; FERRETS AB Live attenuated influenza vaccines (LAIV) offer significant advantages over subunit or split inactivated vaccines to mitigate an eventual influenza pandemic, including simpler manufacturing processes and more cross-protective immune responses. Using an established reverse genetics (rg) system for wild-type (wt) A/Leningrad/134/1957 and cold-adapted (ca) A/Leningrad/134/17/1957 (Len17) master donor virus (MDV), we produced and characterized three rg H5N1 reassortant viruses carrying modified HA and intact NA genes from either A/Vietnam/1203/2004 (H5N1, VN1203, clade 1) or A/Egypt/321/2007 (H5N1, EG321, clade 2) virus. A mouse model of infection was used to determine the infectivity and tissue tropism of the parental wt viruses compared to the ca master donor viruses as well as the H5N1 reassortants. All ca viruses showed reduced replication in lungs and enhanced replication in nasal epithelium. In addition, the H5N1 HA and NA enhanced replication in lungs unless it was restricted by the internal genes of the ca MDV. Mice inoculated twice 4 weeks apart with the H5N1 reassortant LAIV candidate viruses developed serum hemagglutination inhibition HI and IgA antibody titers to the homologous and heterologous viruses consistent with protective immunity. These animals remained healthy after challenge inoculation with a lethal dose with homologous or heterologous wt H5N1 highly pathogenic avian influenza (HPAI) viruses. The profiles of viral replication in respiratory tissues and the immunogenicity and protective efficacy characteristics of the two ca H5N1 candidate LAIV viruses warrant further development into a vaccine for human use. C1 [Isakova-Sivak, Irina; Chen, Li-Mei; Bourgeois, Melissa; Matsuoka, Yumiko; Klimov, Alexander; Cox, Nancy J.; Donis, Ruben O.] Ctr Dis Control & Prevent, Influenza Div, Dept Hlth & Human Serv, Atlanta, GA 30333 USA. [Isakova-Sivak, Irina; Rudenko, Larisa] Russian Acad Med Sci, Inst Expt Med, St Petersburg, Russia. [Voeten, J. Theo M.; Heldens, Jacco G. M.; van den Bosch, Han] Nobilon Int BV, Boxmeer, Netherlands. RP Donis, RO (reprint author), Ctr Dis Control & Prevent, Influenza Div, Dept Hlth & Human Serv, Atlanta, GA 30333 USA. EM rvd6@cdc.gov RI Rudenko, Larisa/B-5169-2015; Isakova-Sivak, Irina/C-1034-2014 OI Rudenko, Larisa/0000-0002-0107-9959; Isakova-Sivak, Irina/0000-0002-2801-1508 NR 53 TC 4 Z9 4 U1 1 U2 10 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 EI 1556-679X J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD MAY PY 2014 VL 21 IS 5 BP 722 EP 731 DI 10.1128/CVI.00819-13 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AJ0NU UT WOS:000337352300016 PM 24648485 ER PT J AU Braun, JM Kalkbrenner, AE Just, AC Yolton, K Calafat, AM Sjodin, A Hauser, R Webster, GM Chen, AM Lanphear, BP AF Braun, Joseph M. Kalkbrenner, Amy E. Just, Allan C. Yolton, Kimberly Calafat, Antonia M. Sjodin, Andreas Hauser, Russ Webster, Glenys M. Chen, Aimin Lanphear, Bruce P. TI Gestational Exposure to Endocrine-Disrupting Chemicals and Reciprocal Social, Repetitive, and Stereotypic Behaviors in 4-and 5-Year-Old Children: The HOME Study SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID ATTENTION DEFICIT/HYPERACTIVITY DISORDER; POLYBROMINATED DIPHENYL ETHERS; PERSISTENT ORGANIC POLLUTANTS; AUTISM SPECTRUM DISORDERS; BISPHENOL-A EXPOSURE; POLYFLUOROALKYL CHEMICALS; HIERARCHICAL REGRESSION; ORGANOCHLORINE EXPOSURE; CHILDHOOD BEHAVIOR; PERINATAL EXPOSURE AB Background: Endocrine-disrupting chemicals (EDCs) may be involved in the etiology of autism spectrum disorders, but identifying relevant chemicals within mixtures of EDCs is difficult. Objective: Our goal was to identify gestational EDC exposures associated with autistic behaviors. Methods: We measured the concentrations of 8 phthalate metabolites, bisphenol A, 25 polychlorinated biphenyls (PCBs), 6 organochlorine pesticides, 8 brominated flame retardants, and 4 perfluoroalkyl substances in blood or urine samples from 175 pregnant women in the HOME (Health Outcomes and Measures of the Environment) Study (Cincinnati, OH). When children were 4 and 5 years old, mothers completed the Social Responsiveness Scale (SRS), a measure of autistic behaviors. We examined confounder-adjusted associations between 52 EDCs and SRS scores using a two-stage hierarchical analysis to account for repeated measures and confounding by correlated EDCs. Results: Most of the EDCs were associated with negligible absolute differences in SRS scores (<= 1.5). Each 2-SD increase in serum concentrations of polybrominated diphenyl ether-28 (PBDE-28) (beta = 2.5; 95% CI: -0.6, 5.6) or trans-nonachlor (beta = 4.1; 95% CI: 0.8-7.3) was associated with more autistic behaviors. In contrast, fewer autistic behaviors were observed among children born to women with detectable versus nondetectable concentrations of PCB-178 (beta = -3.0; 95% CI: -6.3, 0.2), beta-hexachlorocyclohexane (beta = -3.3; 95% CI: -6.1, -0.5), or PBDE-85 (beta = -3.2; 95% CI: -5.9, -0.5). Increasing perfluorooctanoate (PFOA) concentrations were also associated with fewer autistic behaviors (beta = -2.0; 95% CI: -4.4, 0.4). Conclusions: Some EDCs were associated with autistic behaviors in this cohort, but our modest sample size precludes us from dismissing chemicals with null associations. PFOA, beta-hexachlorocyclohexane, PCB-178, PBDE-28, PBDE-85, and trans-nonachlor deserve additional scrutiny as factors that may be associated with childhood autistic behaviors. C1 [Braun, Joseph M.] Brown Univ, Dept Epidemiol, Providence, RI 02912 USA. [Kalkbrenner, Amy E.] Univ Wisconsin, Zilber Sch Publ Hlth, Milwaukee, WI 53201 USA. [Just, Allan C.; Hauser, Russ] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA. [Yolton, Kimberly] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA. [Calafat, Antonia M.; Sjodin, Andreas] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA USA. [Webster, Glenys M.; Lanphear, Bruce P.] Simon Fraser Univ, Fac Hlth & Sci, Burnaby, BC V5A 1S6, Canada. [Webster, Glenys M.; Lanphear, Bruce P.] BC Childrens & Womens Hosp, Child & Family Res Inst, Vancouver, BC, Canada. [Chen, Aimin] Univ Cincinnati, Dept Environm Hlth, Div Epidemiol & Biostat, Cincinnati, OH USA. RP Braun, JM (reprint author), Brown Univ, Dept Epidemiol, Box G S121-2, Providence, RI 02912 USA. EM joseph_braun_1@brown.edu RI Sjodin, Andreas/F-2464-2010; Braun, Joseph/H-8649-2014; OI Just, Allan/0000-0003-4312-5957 FU NIEHS NIH HHS [R01 ES020349, P01 ES011261, P01 ES11261, P30 ES006096, R00 ES020346, R01 ES014575] NR 63 TC 46 Z9 48 U1 7 U2 54 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD MAY PY 2014 VL 122 IS 5 BP 513 EP 520 DI 10.1289/ehp.1307261 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA AJ3ZC UT WOS:000337606300022 PM 24622245 ER PT J AU Kobrosly, RW Evans, S Miodovnik, A Barrett, ES Thurston, SW Calafat, AM Swan, SH AF Kobrosly, Roni W. Evans, Sarah Miodovnik, Amir Barrett, Emily S. Thurston, Sally W. Calafat, Antonia M. Swan, Shanna H. TI Prenatal Phthalate Exposures and Neurobehavioral Development Scores in Boys and Girls at 6-10 Years of Age SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID CHILD-BEHAVIOR CHECKLIST; URINARY PHTHALATE; BISPHENOL-A; METABOLITE CONCENTRATIONS; ENVIRONMENTAL CHEMICALS; REPRODUCTIVE AGE; NATIONAL-HEALTH; PREGNANT-WOMEN; US POPULATION; YOUNG-ADULTS AB Background: There is concern over potential neurobehavioral effects of prenatal phthalate exposures, but available data are inconsistent. Objectives: We examined associations between prenatal urinary concentrations of phthalate metabolites and neurobehavioral scores among children. Methods: We measured phthalate metabolite concentrations in urine samples from 153 pregnant participants in the Study for Future Families, a multicenter cohort study. Mothers completed the Child Behavior Checklist when the children were 6-10 years of age. We estimated overall and sexspecific associations between phthalate concentrations and behavior using adjusted multiple regression interaction models. Results: In boys, concentrations of monoisobutyl phthalate were associated with higher scores for inattention (beta = 0.27; 95% CI: 0.04, 0.50), rule-breaking behavior (beta = 0.20; 95% CI: 0.01, 0.38), aggression (beta = 0.34; 95% CI: 0.09, 0.59), and conduct problems (beta = 0.39; 95% CI: 0.20, 0.58), whereas the molar sum of di(2-ethylhexyl) phthalate metabolites was associated with higher scores for somatic problems (beta = 0.15; 95% CI: 0.03, 0.28). Higher monobenzyl phthalate concentrations were associated with higher scores for oppositional behavior (beta = 0.16; 95% CI: 0.01, 0.32) and conduct problems (beta = 0.21; 95% CI: 0.06, 0.37) in boys, but with reduced anxiety scores in girls (beta = -0.20; 95% CI: -0.39, -0.01). In general, the associations reported above were close to the null among girls. Model coefficients represent the difference in the square root-transformed outcome score associated with a 1-unit increase in log-transformed metabolites. Conclusions: Our results suggest associations between exposure to certain phthalates in late pregnancy and behavioral problems in boys. Given the few studies on this topic and methodological and population differences among studies, additional research is warranted. C1 [Kobrosly, Roni W.; Evans, Sarah; Miodovnik, Amir; Swan, Shanna H.] Icahn Sch Med Mt Sinai, Dept Prevent Med, New York, NY USA. [Barrett, Emily S.] Univ Rochester, Sch Med & Dent, Dept Obstet & Gynecol, Rochester, NY 14642 USA. [Thurston, Sally W.] Univ Rochester, Sch Med & Dent, Dept Biostat & Computat Biol, Rochester, NY USA. [Calafat, Antonia M.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA USA. RP Kobrosly, RW (reprint author), Mt Sinai Sch Med, Dept Prevent Med, One Gustave L Levy Pl,Box 1057, New York, NY 10029 USA. EM roni.kobrosly@mssm.edu FU NCATS NIH HHS [KL2 TR000095, TL1 TR000096, UL1 TR000042]; NCRR NIH HHS [M01 RR000425, M01 RR000400, M01-RR00400, M01-RR0425, UL1 RR024160]; NICHD NIH HHS [T32 HD049311]; NIEHS NIH HHS [K12 ES019852, P30 ES023515, R01 ES009916, R01-ES09916] NR 49 TC 25 Z9 26 U1 1 U2 20 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD MAY PY 2014 VL 122 IS 5 BP 521 EP 528 DI 10.1289/ehp.1307063 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA AJ3ZC UT WOS:000337606300023 PM 24577876 ER PT J AU Golding, J Steer, CD Lowery, T Jones, R Hibbeln, JR AF Golding, Jean Steer, Colin D. Lowery, Tony Jones, Robert Hibbeln, Joseph R. TI Fish Consumption and Blood Mercury Levels: Golding et al. Respond SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Letter ID UK TOTAL DIET C1 [Golding, Jean; Steer, Colin D.] Univ Bristol, Ctr Child & Adolescent Hlth, Bristol, RI 02809 USA. [Lowery, Tony] Natl Ocean & Atmospher Adm, Natl Marine Fisheries Serv, Natl Seafood Inspect Lab, Pascagoula, MS USA. [Jones, Robert] Ctr Dis Control & Prevent, Inorgan & Radiat Analyt Toxicol Branch, Atlanta, GA USA. [Hibbeln, Joseph R.] NIAAA, NIH, Dept Hlth & Human Serv, Bethesda, MD USA. RP Golding, J (reprint author), Univ Bristol, Ctr Child & Adolescent Hlth, Bristol, RI 02809 USA. EM Jean.Golding@bristol.ac.uk OI Golding, Jean/0000-0003-2826-3307 NR 3 TC 0 Z9 0 U1 0 U2 10 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD MAY PY 2014 VL 122 IS 5 BP A120 EP A121 DI 10.1289/ehp.1307997R PG 2 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA AJ3ZC UT WOS:000337606300004 PM 24787643 ER PT J AU Guh, AY Limbago, BM Kallen, AJ AF Guh, Alice Y. Limbago, Brandi M. Kallen, Alexander J. TI Epidemiology and prevention of carbapenem-resistant Enterobacteriaceae in the United States SO EXPERT REVIEW OF ANTI-INFECTIVE THERAPY LA English DT Review DE carbapenem-resistant Enterobacteriaceae; infection prevention; Klebsiella pneumoniae carbapenemase; multidrug-resistant organism; New Delhi metallo-beta-lactamase ID KLEBSIELLA-PNEUMONIAE CARBAPENEMASE; METALLO-BETA-LACTAMASE; INTENSIVE-CARE-UNIT; ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY; OUTER-MEMBRANE PROTEIN; INFECTION-CONTROL; ESCHERICHIA-COLI; RISK-FACTORS; GASTROINTESTINAL COLONIZATION; ENVIRONMENTAL CONTAMINATION AB Carbapenem-resistant Enterobacteriaceae (CRE) are multidrug-resistant organisms with few treatment options that cause infections associated with substantial morbidity and mortality. CRE outbreaks have been increasingly reported worldwide and are mainly due to the emergence and spread of strains that produce carbapenemases. In the United States, transmission of CRE is primarily driven by the spread of organisms carrying the Klebsiella pneumoniae carbapenemase enzyme, but other carbapenemase enzymes, such as the New-Delhi metallo-beta-lactamase, have also emerged. Currently recommended control strategies for healthcare facilities include the detection of patients infected or colonized with CRE and implementation of measures to prevent further spread. In addition to efforts in individual facilities, effective CRE control requires coordination across all healthcare facilities in a region. This review describes the current epidemiology and surveillance of CRE in the United States and the recommended approach to prevention. C1 [Guh, Alice Y.; Limbago, Brandi M.; Kallen, Alexander J.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. RP Guh, AY (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. EM ggt4@cdc.gov NR 138 TC 20 Z9 23 U1 2 U2 18 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1478-7210 EI 1744-8336 J9 EXPERT REV ANTI-INFE JI Expert Rev. Anti-Infect. Ther. PD MAY PY 2014 VL 12 IS 5 BP 565 EP 580 DI 10.1586/14787210.2014.902306 PG 16 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA AJ2NO UT WOS:000337493200007 PM 24666262 ER PT J AU Hughes, AJ Mattson, CL Scheer, S Beer, L Skarbinski, J AF Hughes, Alison J. Mattson, Christine L. Scheer, Susan Beer, Linda Skarbinski, Jacek TI Discontinuation of Antiretroviral Therapy Among Adults Receiving HIV Care in the United States SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV/AIDS; antiretroviral therapy; discontinuation; HIV care ID HUMAN-IMMUNODEFICIENCY-VIRUS; INJECTION-DRUG USERS; MEDICATION ADHERENCE; INFECTED INDIVIDUALS; PROSPECTIVE COHORT; AIDS DIAGNOSIS; HEALTH BELIEFS; CELL COUNTS; HAART; TRANSMISSION AB Background: Continuous antiretroviral therapy (ART) is important for maintaining viral suppression. This analysis estimates prevalence of and reason for ART discontinuation. Methods: Three-stage sampling was used to obtain a nationally representative, cross-sectional sample of HIV-infected adults receiving HIV care. Face-to-face interviews and medical record abstractions were collected from June 2009 to May 2010. Data were weighted based on known probabilities of selection and adjusted for nonresponse. Patient characteristics of ART discontinuation, defined as not currently taking ART, stratified by provider-initiated versus non-provider-initiated discontinuation, were examined. Weighted logistic regression models predicted factors associated with ART discontinuation. Results: Of adults receiving HIV care in the United States who reported ever initiating ART, 5.6% discontinued treatment. Half of those who discontinued treatment reported provider-initiated discontinuation. Provider-initiated ART discontinuation patients were more likely to have a nadir CD4 >= 200 cells per cubic millimeter. Non-provider-initiated ART discontinuation patients were more likely to have unmet need for supportive services and to have not received HIV care in the past 3 months. Among all patients who discontinued, younger age, female gender, not having continuous health insurance, incarceration, injection drug use, nadir CD4 count >= 200 cells per cubic millimeter, unmet need for supportive services, no care in the past 3 months and HIV diagnosis >= 5 years before interview were independently associated with ART discontinuation. Conclusions: These findings inform development of interventions to increase ART persistence by identifying groups at increased risk of ART discontinuation. Evidence-based interventions targeting vulnerable populations are needed and are increasingly important as recent HIV treatment guidelines have recommended universal ART. C1 [Hughes, Alison J.; Scheer, Susan] San Francisco Dept Publ Hlth, San Francisco, CA 94102 USA. [Mattson, Christine L.; Beer, Linda; Skarbinski, Jacek] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. RP Hughes, AJ (reprint author), San Francisco Dept Publ Hlth, 25 Van Ness Ave,Suite 500, San Francisco, CA 94102 USA. EM alison.hughes@sfdph.org FU US Government FX Supported by US Government work. NR 55 TC 7 Z9 7 U1 1 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD MAY 1 PY 2014 VL 66 IS 1 BP 80 EP 89 PG 10 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AJ4YF UT WOS:000337685400016 PM 24326608 ER PT J AU Wallace, A Kimambo, S Dafrossa, L Rusibamayila, N Rwebembera, A Songoro, J Arthur, G Luman, E Finkbeiner, T Goodson, JL AF Wallace, Aaron Kimambo, Sajida Dafrossa, Lyimo Rusibamayila, Neema Rwebembera, Anath Songoro, Juma Arthur, Gilly Luman, Elizabeth Finkbeiner, Thomas Goodson, James L. TI Qualitative Assessment of the Integration of HIV Services With Infant Routine Immunization Visits in Tanzania SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV; AIDS; immunization; integration ID TO-CHILD TRANSMISSION; PREGNANT-WOMEN; FOLLOW-UP; PREVENTION; ATTITUDES; THERAPY; MOTHERS; STIGMA AB Background: In 2009, a project was implemented in 8 primary health clinics throughout Tanzania to explore the feasibility of integrating pediatric HIV prevention services with routine infant immunization visits. Methods: We conducted interviews with 64 conveniently sampled mothers of infants who had received integrated HIV and immunization services and 16 providers who delivered the integrated services to qualitatively identify benefits and challenges of the intervention midway through project implementation. Findings: Mothers' perceived benefits of the integrated services included time savings, opportunity to learn their child's HIV status and receive HIV treatment, if necessary. Providers' perceived benefits included reaching mothers who usually would not come for only HIV testing. Mothers and providers reported similar challenges, including mothers' fear of HIV testing, poor spousal support, perceived mandatory HIV testing, poor patient flow affecting confidentiality of service delivery, heavier provider workloads, and community stigma against HIV-infected persons; the latter a more frequent theme in rural compared with urban locations. Interpretation: Future scale-up should ensure privacy of these integrated services received at clinics and community outreach to address stigma and perceived mandatory testing. Increasing human resources for health to address higher workloads and longer waiting times for proper patient flow is necessary in the long term. C1 [Wallace, Aaron; Luman, Elizabeth; Goodson, James L.] Ctr Dis Control & Prevent, Global Immunizat Div, Atlanta, GA 30333 USA. [Kimambo, Sajida; Arthur, Gilly; Finkbeiner, Thomas] Ctr Dis Control & Prevent, Div Global HIV AIDS, Dar Es Salaam, Tanzania. [Dafrossa, Lyimo] Minist Hlth & Social Welf, Expanded Programme Immunizat, Dar Es Salaam, Tanzania. [Rusibamayila, Neema] Minist Hlth & Social Welf, Reprod Child Hlth Serv, Dar Es Salaam, Tanzania. [Rwebembera, Anath] Minist Hlth & Social Welf, Natl AIDS Control Programme, Dar Es Salaam, Tanzania. [Songoro, Juma] Elizabeth Glaser Pediat AIDS Fdn, Dar Es Salaam, Tanzania. RP Wallace, A (reprint author), Ctr Dis Control & Prevent, Global Immunizat Div, 1600 Clifton Rd NE,MS E05, Atlanta, GA 30333 USA. EM awallace@cdc.gov FU President's Emergency Plan for AIDS Relief (PEP-FAR) through the US Centers for Disease Control and Prevention FX Supported in part by the President's Emergency Plan for AIDS Relief (PEP-FAR) through the US Centers for Disease Control and Prevention. NR 28 TC 2 Z9 2 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD MAY 1 PY 2014 VL 66 IS 1 BP E8 EP E14 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AJ4YF UT WOS:000337685400002 PM 24326602 ER PT J AU Garske, T Van Kerkhove, MD Yactayo, S Ronveaux, O Lewis, RF Staples, JE Perea, W Ferguson, NM AF Garske, Tini Van Kerkhove, Maria D. Yactayo, Sergio Ronveaux, Olivier Lewis, Rosamund F. Staples, J. Erin Perea, William Ferguson, Neil M. CA Yellow Fever Expert Comm TI Yellow Fever in Africa: Estimating the Burden of Disease and Impact of Mass Vaccination from Outbreak and Serological Data SO PLOS MEDICINE LA English DT Article ID INFECTIONS; EPIDEMIC; NIGERIA; ANTIBODIES; RISK; IMMUNIZATION; REEMERGENCE; PERSISTENCE; MORTALITY; PROGRAM AB Background: Yellow fever is a vector-borne disease affecting humans and non-human primates in tropical areas of Africa and South America. While eradication is not feasible due to the wildlife reservoir, large scale vaccination activities in Africa during the 1940s to 1960s reduced yellow fever incidence for several decades. However, after a period of low vaccination coverage, yellow fever has resurged in the continent. Since 2006 there has been substantial funding for large preventive mass vaccination campaigns in the most affected countries in Africa to curb the rising burden of disease and control future outbreaks. Contemporary estimates of the yellow fever disease burden are lacking, and the present study aimed to update the previous estimates on the basis of more recent yellow fever occurrence data and improved estimation methods. Methods and Findings: Generalised linear regression models were fitted to a dataset of the locations of yellow fever outbreaks within the last 25 years to estimate the probability of outbreak reports across the endemic zone. Environmental variables and indicators for the surveillance quality in the affected countries were used as covariates. By comparing probabilities of outbreak reports estimated in the regression with the force of infection estimated for a limited set of locations for which serological surveys were available, the detection probability per case and the force of infection were estimated across the endemic zone. The yellow fever burden in Africa was estimated for the year 2013 as 130,000 (95% CI 51,000-380,000) cases with fever and jaundice or haemorrhage including 78,000 (95% CI 19,000-180,000) deaths, taking into account the current level of vaccination coverage. The impact of the recent mass vaccination campaigns was assessed by evaluating the difference between the estimates obtained for the current vaccination coverage and for a hypothetical scenario excluding these vaccination campaigns. Vaccination campaigns were estimated to have reduced the number of cases and deaths by 27% (95% CI 22%-31%) across the region, achieving up to an 82% reduction in countries targeted by these campaigns. A limitation of our study is the high level of uncertainty in our estimates arising from the sparseness of data available from both surveillance and serological surveys. Conclusions: With the estimation method presented here, spatial estimates of transmission intensity can be combined with vaccination coverage levels to evaluate the impact of past or proposed vaccination campaigns, thereby helping to allocate resources efficiently for yellow fever control. This method has been used by the Global Alliance for Vaccines and Immunization (GAVI Alliance) to estimate the potential impact of future vaccination campaigns. C1 [Garske, Tini; Van Kerkhove, Maria D.; Ferguson, Neil M.] Imperial Coll London, Dept Infect Dis Epidemiol, MRC Ctr Outbreak Anal, London, England. [Yactayo, Sergio; Perea, William] World Hlth Org, Geneva, Switzerland. [Ronveaux, Olivier] World Hlth Org, Ouagadougou, Burkina Faso. [Lewis, Rosamund F.] Ottawa Publ Hlth, Ottawa, ON, Canada. [Staples, J. Erin] Ctr Dis Control & Prevent, Arboviral Dis Branch, Ft Collins, CO USA. RP Garske, T (reprint author), Imperial Coll London, Dept Infect Dis Epidemiol, MRC Ctr Outbreak Anal, London, England. EM neil.ferguson@imperial.ac.uk RI Ferguson, Neil/B-8578-2008; OI Ferguson, Neil/0000-0002-1154-8093; /0000-0002-5704-8094 FU Medical Research Council; Bill & Melinda Gates Foundation; European Union [278433-PREDEMICS] FX The research leading to these results has received funding from the Medical Research Council, the Bill & Melinda Gates Foundation, and the European Union Seventh Framework Programme [FP7/2007-2013] under Grant Agreement no 278433-PREDEMICS. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 52 TC 27 Z9 27 U1 1 U2 14 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1549-1676 J9 PLOS MED JI PLos Med. PD MAY PY 2014 VL 11 IS 5 AR e1001638 DI 10.1371/journal.pmed.1001638 PG 17 WC Medicine, General & Internal SC General & Internal Medicine GA AJ0MY UT WOS:000337349300001 PM 24800812 ER PT J AU Gautret, P Blanton, J Dacheux, L Ribadeau-Dumas, F Brouqui, P Parola, P Esposito, DH Bourhy, H AF Gautret, Philippe Blanton, Jesse Dacheux, Laurent Ribadeau-Dumas, Florence Brouqui, Philippe Parola, Philippe Esposito, Douglas H. Bourhy, Herve TI Rabies in Nonhuman Primates and Potential for Transmission to Humans: A Literature Review and Examination of Selected French National Data SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Review ID POSTEXPOSURE PROPHYLAXIS; NEW-ZEALAND; TRAVELERS; EXPOSURE; VIRUS; BITES; SURVEILLANCE; INJURIES; WILDLIFE; MONKEY AB Background: The nonhuman primate (NHP)-related injuries in rabies-enzootic countries is a public health problem of increasing importance. The aims of this work are to collect data concerning rabies transmission from NHPs to humans; to collate medical practices regarding rabies postexposure prophylaxis (PEP) in different countries, and to provide an evidence base to support the decision to apply rabies PEP in this context. Methodology: To retrieve information, we conducted a literature search from 1960 to January 2013. All reports of rabies in NHPs and rabies transmission to humans by infected NHPs were included. Also included were studies of travelers seeking care for rabies PEP in various settings. Data collected by the French National Reference Centre for Rabies concerning NHPs submitted for rabies diagnosis in France and human rabies exposure to NHPs in travelers returning to France were analyzed for the periods 1999-2012 and 1994-2011, respectively. Principal findings: A total of 159 reports of rabies in NHPs have been retrieved from various sources in South America, Africa, and Asia, including 13 cases in animals imported to Europe and the US. 134 were laboratory confirmed cases. 25 cases of human rabies following NHP-related injuries were reported, including 20 from Brazil. Among more than 2000 international travelers from various settings, the proportion of injuries related to NHP exposures was about 31%. NHPs rank second, following dogs in most studies and first in studies conducted in travelers returning from Southeast Asia. In France, 15.6% of 1606 travelers seeking PEP for exposure to any animal were injured by monkeys. Conclusions/significance: Although less frequently reported in published literature than human rabies, confirmed rabies cases in NHPs occur. The occurrence of documented transmission of rabies from NHPs to human suggests that rabies PEP is indicated in patients injured by NHPs in rabies-enzootic countries. C1 [Gautret, Philippe; Brouqui, Philippe; Parola, Philippe] CHU Nord, Inst Hosp Univ Mediterranee Infect, Assistance Publ Hop Marseille, Marseille, France. [Gautret, Philippe; Brouqui, Philippe; Parola, Philippe] Aix Marseille Univ, URMITE, UM63, CNRS 7278,IRD 198,Inserm 1095,Fac Med, Marseille, France. [Blanton, Jesse] Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. [Dacheux, Laurent; Ribadeau-Dumas, Florence; Bourhy, Herve] WHO Collaborating Ctr Reference & Res Rabies, Inst Pasteur, Unite Dynam Lyssavirus & Adaptat Hote, Natl Reference Ctr Rabies, Paris, France. [Esposito, Douglas H.] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. RP Gautret, P (reprint author), CHU Nord, Inst Hosp Univ Mediterranee Infect, Assistance Publ Hop Marseille, Marseille, France. EM philippe.gautret@club-internet.fr RI Brouqui, Philippe/P-5771-2016 NR 40 TC 10 Z9 10 U1 4 U2 16 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD MAY PY 2014 VL 8 IS 5 AR e2863 DI 10.1371/journal.pntd.0002863 PG 7 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AJ5OS UT WOS:000337735100051 PM 24831694 ER PT J AU Kamuyu, G Bottomley, C Mageto, J Lowe, B Wilkins, PP Noh, JC Nutman, TB Ngugi, AK Odhiambo, R Wagner, RG Kakooza-Mwesige, A Owusu-Agyei, S Ae-Ngibise, K Masanja, H Osier, FHA Odermatt, P Newton, CR AF Kamuyu, Gathoni Bottomley, Christian Mageto, James Lowe, Brett Wilkins, Patricia P. Noh, John C. Nutman, Thomas B. Ngugi, Anthony K. Odhiambo, Rachael Wagner, Ryan G. Kakooza-Mwesige, Angelina Owusu-Agyei, Seth Ae-Ngibise, Kenneth Masanja, Honorati Osier, Faith H. A. Odermatt, Peter Newton, Charles R. CA Epidemiology Epilepsy Demographic TI Exposure to Multiple Parasites Is Associated with the Prevalence of Active Convulsive Epilepsy in Sub-Saharan Africa SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID TOXOPLASMA-GONDII; ONCHOCERCA-VOLVULUS; CRYPTOGENIC EPILEPSY; RURAL TANZANIA; RISK-FACTORS; NEUROCYSTICERCOSIS; TOXOCARIASIS; CYSTICERCOSIS; INFECTION; RESPONSES AB Background: Epilepsy is common in developing countries, and it is often associated with parasitic infections. We investigated the relationship between exposure to parasitic infections, particularly multiple infections and active convulsive epilepsy (ACE), in five sites across sub-Saharan Africa. Methods and Findings: A case-control design that matched on age and location was used. Blood samples were collected from 986 prevalent cases and 1,313 age-matched community controls and tested for presence of antibodies to Onchocerca volvulus, Toxocara canis, Toxoplasma gondii, Plasmodium falciparum, Taenia solium and HIV. Exposure (seropositivity) to Onchocerca volvulus (OR = 1.98; 95% CI: 1.52-2.58, p<0.001), Toxocara canis (OR = 1.52; 95% CI: 1.23-1.87, p<0.001), Toxoplasma gondii (OR = 1.28; 95% CI: 1.04-1.56, p=0.018) and higher antibody levels (top tertile) to Toxocara canis (OR = 1.70; 95% CI: 1.30-2.24, p<0.001) were associated with an increased prevalence of ACE. Exposure to multiple infections was common (73.8% of cases and 65.5% of controls had been exposed to two or more infections), and for T. gondii and O. volvulus co-infection, their combined effect on the prevalence of ACE, as determined by the relative excess risk due to interaction (RERI), was more than additive (T. gondii and O. volvulus, RERI = 1.19). The prevalence of T. solium antibodies was low (2.8% of cases and 2.2% of controls) and was not associated with ACE in the study areas. Conclusion: This study investigates how the degree of exposure to parasites and multiple parasitic infections are associated with ACE and may explain conflicting results obtained when only seropositivity is considered. The findings from this study should be further validated. C1 [Kamuyu, Gathoni; Mageto, James; Lowe, Brett; Ngugi, Anthony K.; Odhiambo, Rachael; Osier, Faith H. A.; Newton, Charles R.] KEMRI Wellcome Trust Res Programme, Ctr Geog Med Res Coast, Kilifi, Kenya. [Kamuyu, Gathoni; Lowe, Brett; Ngugi, Anthony K.; Kakooza-Mwesige, Angelina; Newton, Charles R.] Studies Epidemiol Epilepsy Demog Surveillance Sys, Accra, Ghana. [Bottomley, Christian] London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, Dept Infect Dis Epidemiol, London WC1, England. [Bottomley, Christian] London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, MRC Trop Epidemiol Grp, London WC1, England. [Bottomley, Christian] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, London WC1, England. [Mageto, James] Egerton Univ, Nakuru, Kenya. [Lowe, Brett] Univ Oxford, Nuffield Dept Clin Med, Oxford, England. [Wilkins, Patricia P.; Noh, John C.] Ctr Dis Control & Prevent CDC, Div Parasit Dis & Malaria, Atlanta, GA USA. [Nutman, Thomas B.] NIAID, Parasit Dis Lab, Bethesda, MD 20892 USA. [Ngugi, Anthony K.] Aga Khan Univ East Africa, Fac Hlth Sci, Res Support Unit, Nairobi, Kenya. [Wagner, Ryan G.] Univ Witwatersrand, Fac Hlth Sci, Sch Publ Hlth, MRC Wits Rural Publ Hlth & Hlth Transit Res Unit, Johannesburg, South Africa. [Wagner, Ryan G.] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden. [Kakooza-Mwesige, Angelina] Iganga Mayuge Hlth & Demog Surveillance Syst, Iganga, Uganda. [Kakooza-Mwesige, Angelina] Makerere Univ, Coll Hlth Sci, Dept Paediat & Child Hlth, Kampala, Uganda. [Owusu-Agyei, Seth; Ae-Ngibise, Kenneth] Kintampo Hlth Res Ctr, Kintampo, Ghana. [Masanja, Honorati] Ifakara Hlth Inst, Ifakara, Tanzania. [Odermatt, Peter] Swiss Trop & Publ Hlth Inst, Basel, Switzerland. [Odermatt, Peter] Unvers Basel, Basel, Switzerland. [Newton, Charles R.] UCL Inst Child Hlth, Neurosci Unit, London, England. [Newton, Charles R.] London Sch Hyg & Trop Med, Clin Res Unit, London WC1, England. [Newton, Charles R.] Univ Oxford, Dept Psychiat, Oxford, England. RP Kamuyu, G (reprint author), KEMRI Wellcome Trust Res Programme, Ctr Geog Med Res Coast, Kilifi, Kenya. EM GKamuyu@kemri-wellcome.org RI Sander, Josemir/C-1576-2008; Odermatt, Peter/K-7727-2015; OI Sander, Josemir/0000-0001-6041-9661; Odermatt, Peter/0000-0002-0296-2508; Osier, Faith/0000-0001-7133-5375; Newton, Charles/0000-0002-6999-5507 FU Wellcome Trust through a Wellcome Trust Senior Fellowship in Clinical Tropical Medicine [083744]; Wellcome Trust through a strategic training award [084538]; Wellcome Trust Master's Training Fellowship [096392] FX The Wellcome Trust funded this research through a Wellcome Trust Senior Fellowship in Clinical Tropical Medicine (No. 083744 to CRN), and supported GK to write up this work through a strategic training award (No. 084538) and a Wellcome Trust Master's Training Fellowship (No. 096392) to KEMRI-Wellcome Trust Research Programme. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 52 TC 20 Z9 20 U1 0 U2 18 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD MAY PY 2014 VL 8 IS 5 AR e2908 DI 10.1371/journal.pntd.0002908 PG 10 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AJ5OS UT WOS:000337735100075 PM 24875312 ER PT J AU Jacobson, EU Inglesby, T Khan, AS Rajotte, JC Burhans, RL Slemp, CC Links, JM AF Jacobson, Evin Uzun Inglesby, Tom Khan, Ali S. Rajotte, James C. Burhans, Robert L. Slemp, Catherine C. Links, Jonathan M. TI DESIGN OF THE NATIONAL HEALTH SECURITY PREPAREDNESS INDEX SO BIOSECURITY AND BIOTERRORISM-BIODEFENSE STRATEGY PRACTICE AND SCIENCE LA English DT Article AB The importance of health security in the United States has been highlighted by recent emergencies such as the H1N1 influenza pandemic, Superstorm Sandy, and the Boston Marathon bombing. The nation's health security remains a high priority today, with federal, state, territorial, tribal, and local governments, as well as nongovernment organizations and the private sector, engaging in activities that prevent, protect, mitigate, respond to, and recover from health threats. The Association of State and Territorial Health Officials (ASTHO), through a cooperative agreement with the Centers for Disease Control and Prevention (CDC) Office of Public Health Preparedness and Response (OPHPR), led an effort to create an annual measure of health security preparedness at the national level. The collaborative released the National Health Security Preparedness Index (NHSPI (TM)) in December 2013 and provided composite results for the 50 states and for the nation as a whole. The Index results represent current levels of health security preparedness in a consistent format and provide actionable information to drive decision making for continuous improvement of the nation's health security. The overall 2013 National Index result was 7.2 on the reported base-10 scale, with areas of greater strength in the domains of health surveillance, incident and information management, and countermeasure management. The strength of the Index relies on the interdependencies of the many elements in health security preparedness, making the sum greater than its parts. Moving forward, additional health security-related disciplines and measures will be included alongside continued validation efforts. C1 [Jacobson, Evin Uzun; Khan, Ali S.; Rajotte, James C.] Ctr Dis Control & Prevent, Off Policy Planning & Evaluat, Atlanta, GA 30333 USA. [Jacobson, Evin Uzun; Khan, Ali S.; Rajotte, James C.] Ctr Dis Control & Prevent, Off Publ Hlth Preparedness & Response, Atlanta, GA 30333 USA. [Inglesby, Tom] UPMC Ctr Hlth Secur, Baltimore, MD USA. [Burhans, Robert L.] New York State Dept Hlth, Woodstock, NY USA. [Slemp, Catherine C.] West Virginia Bur Publ Hlth, Huntington, WV USA. [Links, Jonathan M.] Johns Hopkins Univ, Ctr Publ Hlth Preparedness, Baltimore, MD USA. RP Jacobson, EU (reprint author), Ctr Dis Control & Prevent, Off Publ Hlth Preparedness & Response, 1600 Clifton Rd,Mailstop D-44, Atlanta, GA 30333 USA. EM wqm4@cdc.gov NR 3 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1538-7135 EI 1557-850X J9 BIOSECUR BIOTERROR JI Biosecur. Bioterror. PD MAY-JUN PY 2014 VL 12 IS 3 BP 122 EP 131 DI 10.1089/bsp.2014.0024 PG 10 WC Public, Environmental & Occupational Health; International Relations SC Public, Environmental & Occupational Health; International Relations GA AI9BP UT WOS:000337221900002 ER PT J AU Uhrig, JD Friedman, A Poehlman, J Scales, M Forsythe, A AF Uhrig, Jennifer D. Friedman, Allison Poehlman, Jon Scales, Monica Forsythe, Ann TI Knowledge, beliefs and behaviours related to STD risk, prevention, and screening among a sample of African American men and women SO HEALTH EDUCATION JOURNAL LA English DT Article DE African American; health communication; health disparities; STD; USA ID HIV; DISPARITIES; COMMUNICATION; INTERVENTIONS; INFECTIONS; HIV/AIDS AB Objective: Current data on sexually transmitted disease (STD) among African Americans show significant racial/ethnic disparities. The purpose of this study was to explore knowledge, attitudes, beliefs, and behaviours related to STD risk, prevention, and testing among African American adults to help inform the development of a health communication intervention to address the high rates of STDs in this community. Design: Cross-sectional survey. Setting: Four United States (US) communities with high cumulative incidence of STDs. Method: We administered a 44-item structured survey. Results: Participants were 185 sexually active heterosexual African Americans aged 18 to 45. Most participants (84.2%) had been tested for an STD at least once. Most participants (75.8%) perceived STDs to be a problem in their community, and almost all (91.2%) felt that people needed education to learn how to avoid STDs. Nonetheless, only half of participants (49.5%) agreed that they should get tested for STDs because they may be at risk. Misconceptions related to STD prevention and testing were identified. Results suggest that STDs remain highly stigmatized with concerns related to social and interpersonal consequences. Participants' perceived personal risk was low, despite acknowledging high STD rates in their communities. Conclusion: Findings suggest that health communication may play an important role in addressing STD disparities by increasing perceptions of personal risk, minimizing STD-associated stigma, and marketing STD prevention and testing behaviours. C1 [Friedman, Allison; Forsythe, Ann] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Uhrig, JD (reprint author), Hlth Commun Program, RTI 3040 Cornwallis Rd, Res Triangle Pk, NC 27709 USA. EM uhrig@rti.org NR 20 TC 1 Z9 1 U1 1 U2 9 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0017-8969 EI 1748-8176 J9 HEALTH EDUC J JI Health Educ. J. PD MAY PY 2014 VL 73 IS 3 BP 332 EP 340 DI 10.1177/0017896912471054 PG 9 WC Education & Educational Research; Public, Environmental & Occupational Health SC Education & Educational Research; Public, Environmental & Occupational Health GA AI9VD UT WOS:000337288200009 ER PT J AU Chotiwan, N Roehrig, JT Schlesinger, JJ Blair, CD Huang, CYH AF Chotiwan, Nunya Roehrig, John T. Schlesinger, Jacob J. Blair, Carol D. Huang, Claire Y. -H. TI Molecular determinants of dengue virus 2 envelope protein important for virus entry in Fc gamma RIIA-Mediated antibody-dependent enhancement of infection SO VIROLOGY LA English DT Article DE Dengue virus; Envelope protein; Antibody-dependent enhancement; Fc gamma RIIA; Virus entry ID HEMORRHAGIC-FEVER; DOMAIN-III; MEMBRANE-FUSION; HEPARAN-SULFATE; VERO CELLS; GLYCOPROTEIN; PATHOGENESIS; COMPLEX; BINDING; EPITOPES AB Antibody-dependent enhancement (ADE) of infection may cause severe illness in patients suffering a secondary infection by a heterologous dengue virus (DENV) serotype. During ADE of infection, cross-reactive non- or poorly-neutralizing antibodies form infectious virus-Ab complexes with the newly infecting serotype and enhance virus infection by binding to the Fc gamma receptors (Fc gamma R) on Fc gamma R-bearing cells. In this study, we determined that molecular determinants of DENV2 envelope protein critical for virus entry during non-ADE infection are also required for ADE infection mediated by Fc gamma RIIA, and binding of virus-Ab complexes with Fc gamma RIIA alone is not sufficient for ADE of infection. The Fc gamma RIIA mainly plays an auxiliary role in concentrating the virus-Ab complex to the cell surface, and other primary cellular receptors are required for virus entry. Understanding the viral entry pathway in ADE of DENV infection will greatly facilitate rational designs of anti-viral therapeutics against severe dengue disease associated with ADE. Published by Elsevier Inc. C1 [Chotiwan, Nunya; Roehrig, John T.; Huang, Claire Y. -H.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Arboviral Dis Branch, Ft Collins, CO 80521 USA. [Schlesinger, Jacob J.] Univ Rochester, Dept Med, Rochester, NY 14642 USA. [Blair, Carol D.] Colorado State Univ, Dept Microbiol Immunol & Pathol, Arthropod Borne & Infect Dis Lab, Ft Collins, CO 80523 USA. RP Huang, CYH (reprint author), CDC, DVBD, Arboviral Dis Branch, 3156 Rampart Rd, Ft Collins, CO 80521 USA. EM yxh0@cdc.gov FU Thailand-United States Educational Foundation (Fulbright Thailand) scholarship for a MS degree education at Colorado State University FX We thank Karen Boroughs, Janae Stovall, Kandice Dixon, as well as Drs. Siritorn Butrapet, Amanda Calvert, and Amy Ullmann for their technical assistance. We appreciate all the constructive comments provided by Drs. Richard Kinney and Chaoping Chen. N.C. was supported by the Thailand-United States Educational Foundation (Fulbright Thailand) scholarship for a MS degree education at Colorado State University. NR 43 TC 2 Z9 2 U1 0 U2 3 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD MAY PY 2014 VL 456 BP 238 EP 246 DI 10.1016/j.virol.2014.03.031 PG 9 WC Virology SC Virology GA AI9NF UT WOS:000337258600024 PM 24889243 ER PT J AU Gu, SH Lim, BK Kadjo, B Arai, S Kim, JA Nicolas, V Lalis, A Denys, C Cook, JA Dominguez, SR Holmes, KV Urushadze, L Sidamonidze, K Putkaradze, D Kuzmin, IV Kosoy, MY Song, JW Yanagihara, R AF Gu, Se Hun Lim, Burton K. Kadjo, Blaise Arai, Satoru Kim, Jeong-Ah Nicolas, Violaine Lalis, Aude Denys, Christiane Cook, Joseph A. Dominguez, Samuel R. Holmes, Kathryn V. Urushadze, Lela Sidamonidze, Ketevan Putkaradze, Davit Kuzmin, Ivan V. Kosoy, Michael Y. Song, Jin-Won Yanagihara, Richard TI Molecular Phylogeny of Hantaviruses Harbored by Insectivorous Bats in Cote d'Ivoire and Vietnam SO VIRUSES-BASEL LA English DT Article DE hantavirus; Chiroptera; evolution ID GENETICALLY DISTINCT HANTAVIRUS; NEWFOUND HANTAVIRUS; BORNE HANTAVIRUS; UNITED-STATES; SHREW; VIRUS; EVOLUTION; SEQUENCES; RESERVOIR; GUINEA AB The recent discovery of genetically distinct hantaviruses in multiple species of shrews and moles prompted a further exploration of their host diversification by analyzing frozen, ethanol-fixed and RNAlater (R)-preserved archival tissues and fecal samples from 533 bats (representing seven families, 28 genera and 53 species in the order Chiroptera), captured in Asia, Africa and the Americas in 1981-2012, using RT-PCR. Hantavirus RNA was detected in Pomona roundleaf bats (Hipposideros pomona) (family Hipposideridae), captured in Vietnam in 1997 and 1999, and in banana pipistrelles (Neoromicia nanus) (family Vespertilionidae), captured in Cote d'Ivoire in 2011. Phylogenetic analysis, based on the full-length S- and partial M- and L-segment sequences using maximum likelihood and Bayesian methods, demonstrated that the newfound hantaviruses formed highly divergent lineages, comprising other recently recognized batborne hantaviruses in Sierra Leone and China. The detection of bat-associated hantaviruses opens a new era in hantavirology and provides insights into their evolutionary origins. C1 [Gu, Se Hun; Yanagihara, Richard] Univ Hawaii Manoa, John A Burns Sch Med, Pacific Ctr Emerging Infect Dis Res, Honolulu, HI 96813 USA. [Lim, Burton K.] Royal Ontario Museum, Dept Nat Hist, Toronto, ON M5S 2C6, Canada. [Kadjo, Blaise] Univ Cocody, Dept Biol, Abidjan 22, Cote Ivoire. [Arai, Satoru] Natl Inst Infect Dis, Infect Dis Surveillance Ctr, Tokyo 1628640, Japan. [Kim, Jeong-Ah; Song, Jin-Won] Korea Univ, Coll Med, Dept Microbiol, Seoul 136705, South Korea. [Nicolas, Violaine; Lalis, Aude; Denys, Christiane] Museum Natl Hist Nat, CNRS, UMR 7205, Dept Systemat & Evolut, F-75005 Paris, France. [Cook, Joseph A.] Univ New Mexico, Dept Biol, Museum Southwestern Biol, Albuquerque, NM 87131 USA. [Dominguez, Samuel R.; Holmes, Kathryn V.] Univ Colorado, Sch Med, Dept Pediat, Aurora, CO 80045 USA. [Urushadze, Lela; Sidamonidze, Ketevan; Putkaradze, Davit] Natl Ctr Dis Control & Publ Hlth, GE-0177 Tbilisi, Rep of Georgia. [Urushadze, Lela] Ilia State Univ, Inst Chem Biol, GE-0162 Tbilisi, Rep of Georgia. [Kuzmin, Ivan V.] Global Alliance Rabies Control, Manhattan, KS 66502 USA. [Kosoy, Michael Y.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. RP Yanagihara, R (reprint author), Univ Hawaii Manoa, John A Burns Sch Med, Pacific Ctr Emerging Infect Dis Res, Honolulu, HI 96813 USA. EM sehungu@hawaii.edu; burtonl@rom.on.ca; blaisekadjo1@hotmail.com; arais@nih.go.jp; youminlove3@hotmail.com; vnicolas@mnhn.fr; lalis@mnhn.fr; denys@mnhn.fr; cookjose@unm.edu; samuel.dominguez@ucdenver.edu; Kathryn.Holmes@ucdenver.edu; lelincdc@gmail.com; keti_sida@yahoo.com; dato.putkaradze@yahoo.com; ivkuzmin@yandex.ru; mck3@cdc.gov; jwsong@korea.ac.kr; ryanagih@hawaii.edu FU U.S. Public Health Service grants from the National Institutes of Health [R01AI075057, P20GM103516]; Japan Society for the Promotion of Science [24405045]; Agency for Defense Development of Korea [UE134020ID]; Centers of Biomedical Research Excellence program [P30GM103341]; [H25-Shinko-Ippan-008] FX This work was supported by U.S. Public Health Service grants R01AI075057 and P20GM103516 from the National Institutes of Health, grant 24405045 from the Japan Society for the Promotion of Science, grant H25-Shinko-Ippan-008 for Research on Emerging and Re-emerging Infectious Diseases, and grant UE134020ID from the Agency for Defense Development of Korea. The services provided by the Genomics Core Facility, funded partially by the Centers of Biomedical Research Excellence program (P30GM103341), are gratefully acknowledged. NR 39 TC 9 Z9 9 U1 2 U2 14 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD MAY PY 2014 VL 6 IS 5 BP 1897 EP 1910 DI 10.3390/v6051897 PG 14 WC Virology SC Virology GA AI8JY UT WOS:000337160900002 PM 24784569 ER PT J AU Goodman, RA Boyd, C Tinetti, ME Von Kohorn, I Parekh, AK McGinnis, JM AF Goodman, Richard A. Boyd, Cynthia Tinetti, Mary E. Von Kohorn, Isabelle Parekh, Anand K. McGinnis, J. Michael TI IOM and DHHS Meeting on Making Clinical Practice Guidelines Appropriate for Patients with Multiple Chronic Conditions SO ANNALS OF FAMILY MEDICINE LA English DT Article DE practice guidelines; multiple chronic conditions; comorbidities; institute of Medicine; IOM; Department of Health and Human Services; DHHS ID RANDOMIZED CONTROLLED-TRIALS; DISEASES; CONTEXT; CARE AB BACKGROUND The increasing prevalence of Americans with multiple (2 or more) chronic conditions raises concerns about the appropriateness and applicability of clinical practice guidelines for patient management. Most guidelines clinicians currently rely on have been designed with a single chronic condition in mind, and many such guidelines are inattentive to issues related to comorbidities. PURPOSE In response to the need for guideline developers to address comorbidities in guidelines, the Department of Health and Human Services convened a meeting in May 2012 in partnership with the Institute of Medicine to identify principles and action options. RESULTS Eleven principles to improve guidelines' attentiveness to the population with multiple chronic conditions were identified during the meeting. They are grouped into 3 interrelated categories: (1) principles intended to improve the stakeholder technical process for developing guidelines; (2) principles intended to strengthen content of guidelines in terms of multiple chronic conditions; and (3) principles intended to increase focus on patient-centered care. CONCLUSION This meeting built upon previously recommended actions by identifying additional principles and options for government, guideline developers, and others to use in strengthening the applicability of clinical practice guidelines to the growing population of people with multiple chronic conditions. The suggested principles are helping professional societies to improve guidelines' attentiveness to persons with multiple chronic conditions. C1 [Goodman, Richard A.; Parekh, Anand K.] US Dept Hlth & Human Serv, Off Assistant Secretary Hlth, Washington, DC USA. [Goodman, Richard A.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Goodman, Richard A.] Emory Univ, Div Gen Med & Geriatr, Atlanta, GA 30322 USA. [Boyd, Cynthia] Johns Hopkins Univ, Div Geriatr Med & Gerontol, Baltimore, MD USA. [Tinetti, Mary E.] Yale Univ, Sch Med, Dept Internal Med Geriatr, New Haven, CT USA. [Tinetti, Mary E.] Yale Univ, Sch Publ Hlth, New Haven, CT USA. [Von Kohorn, Isabelle] Holy Cross Hlth, Silver Spring, MD USA. [McGinnis, J. Michael] Natl Acad Sci, Inst Med, Washington, DC 20418 USA. RP Goodman, RA (reprint author), Ctr Dis Control & Prevent, Mailstop K40,4770 Buford Hwy NE, Atlanta, GA 30341 USA. EM rag4@cdc.gov FU AHRQ HHS [R21 HS018597]; NIA NIH HHS [K23 AG032910] NR 30 TC 12 Z9 13 U1 2 U2 5 PU ANNALS FAMILY MEDICINE PI LEAWOOD PA 11400 TOMAHAWK CREEK PARKWAY, LEAWOOD, KS 66211-2672 USA SN 1544-1709 EI 1544-1717 J9 ANN FAM MED JI Ann. Fam. Med. PD MAY-JUN PY 2014 VL 12 IS 3 BP 256 EP 259 DI 10.1370/afm.1646 PG 4 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA AI3YM UT WOS:000336801800010 PM 24821897 ER PT J AU Bayliss, EA Bonds, DE Boyd, CM Davis, MM Finke, B Fox, MH Glasgow, RE Goodman, RA Heurtin-Roberts, S Lachenmayr, S Lind, C Madigan, EA Meyers, DS Mintz, S Nilsen, WJ Okun, S Ruiz, S Salive, ME Stange, KC AF Bayliss, Elizabeth A. Bonds, Denise E. Boyd, Cynthia M. Davis, Melinda M. Finke, Bruce Fox, Michael H. Glasgow, Russell E. Goodman, Richard A. Heurtin-Roberts, Suzanne Lachenmayr, Sue Lind, Cristin Madigan, Elizabeth A. Meyers, David S. Mintz, Suzanne Nilsen, Wendy J. Okun, Sally Ruiz, Sarah Salive, Marcel E. Stange, Kurt C. TI Understanding the Context of Health for Persons With Multiple Chronic Conditions: Moving From What Is the Matter to What Matters SO ANNALS OF FAMILY MEDICINE LA English DT Article DE multiple chronic conditions; chronic illness; health services research ID QUALITY-OF-LIFE; RANDOMIZED CONTROLLED-TRIALS; TEAM SCIENCE; PRIMARY-CARE; EXTERNAL VALIDITY; BIOPSYCHOSOCIAL MODEL; COMPLEXITY SCIENCE; PATIENT-CARE; NEED; MULTIMORBIDITY AB PURPOSE An isolated focus on 1 disease at a time is insufficient to generate the scientific evidence needed to improve the health of persons living with more than 1 chronic condition. This article explores how to bring context into research efforts to improve the health of persons living with multiple chronic conditions (MCC). METHODS Forty-five experts, including persons with MCC, family and friend caregivers, researchers, policy makers, funders, and clinicians met to critically consider 4 aspects of incorporating context into research on MCC: key contextual factors, needed research, essential research methods for understanding important contextual factors, and necessary partnerships for catalyzing collaborative action in conducting and applying research. RESULTS Key contextual factors involve complementary perspectives across multiple levels: public policy, community, health care systems, family, and person, as well as the cellular and molecular levels where most research currently is focused. Needed research involves moving from a disease focus toward a person-driven, goal-directed research agenda. Relevant research methods are participatory, flexible, multilevel, quantitative and qualitative, conducive to longitudinal dynamic measurement from diverse data sources, sufficiently detailed to consider what works for whom in which situation, and generative of ongoing communities of learning, living and practice. Important partnerships for collaborative action include cooperation among members of the research enterprise, health care providers, community-based support, persons with MCC and their family and friend caregivers, policy makers, and payers, including government, public health, philanthropic organizations, and the business community. CONCLUSION Consistent attention to contextual factors is needed to enhance health research for persons with MCC. Rigorous, integrated, participatory, multimethod approaches to generate new knowledge and diverse partnerships can be used to increase the relevance of research to make health care more sustainable, safe, equitable and effective, to reduce suffering, and to improve quality of life. C1 [Bayliss, Elizabeth A.] Kaiser Permanente, Denver, CO USA. [Bonds, Denise E.] NHLBI, Bethesda, MD 20892 USA. [Boyd, Cynthia M.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Boyd, Cynthia M.] Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Davis, Melinda M.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Finke, Bruce] Indian Hlth Serv, Nashville, TN USA. [Fox, Michael H.; Goodman, Richard A.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Glasgow, Russell E.; Heurtin-Roberts, Suzanne] NCI, NIH, Bethesda, MD 20892 USA. [Glasgow, Russell E.] Univ Colorado, Sch Med, Denver, CO USA. [Goodman, Richard A.] Dept Hlth & Human Serv, Off Assistant Secretary Hlth, Atlanta, GA USA. [Lachenmayr, Sue; Ruiz, Sarah] Natl Council Aging, Washington, DC USA. [Lind, Cristin] Karolinska Inst, Stockholm, Sweden. [Meyers, David S.] Agcy Healthcare Res & Qual, Rockville, MD USA. [Nilsen, Wendy J.] NIH, Off Behav & Social Sci Res, Bethesda, MD 20892 USA. [Okun, Sally] PatientsLikeMe, Cambridge, MA USA. [Ruiz, Sarah] Univ Chicago, Chicago, IL 60637 USA. [Salive, Marcel E.] NIA, Bethesda, MD USA. RP Stange, KC (reprint author), Case Western Reserve Univ, 11000 Cedar Ave,Suite 402, Cleveland, OH 44106 USA. EM kcs@case.edu RI Ruiz, Sarah/B-3456-2017 OI Ruiz, Sarah/0000-0002-6428-2321 FU Clinical Research Professorship from the American Cancer Society; National Cancer Society FX Dr Stange's time is supported in part by a Clinical Research Professorship from the American Cancer Society and by the National Cancer Society through the Intergovernmental Personnel Act. NR 99 TC 36 Z9 36 U1 7 U2 45 PU ANNALS FAMILY MEDICINE PI LEAWOOD PA 11400 TOMAHAWK CREEK PARKWAY, LEAWOOD, KS 66211-2672 USA SN 1544-1709 EI 1544-1717 J9 ANN FAM MED JI Ann. Fam. Med. PD MAY-JUN PY 2014 VL 12 IS 3 BP 260 EP 269 DI 10.1370/afm.1643 PG 10 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA AI3YM UT WOS:000336801800011 PM 24821898 ER PT J AU Ross, TM Lin, CJ Nowalk, MP Huang, HH Spencer, SM Shay, DK Sambhara, S Sundaram, ME Friedrich, T Sauereisen, S Bloom, CE Zimmerman, RK AF Ross, Ted M. Lin, Chyongchiou Jeng Nowalk, Mary Patricia Huang, Hsin-Hui Spencer, Sarah M. Shay, David K. Sambhara, Suryaprakash Sundaram, Maria E. Friedrich, Thomas Sauereisen, Sandy Bloom, Chalise E. Zimmerman, Richard K. TI Influence of pre-existing hemagglutination inhibition titers against historical influenza strains on antibody response to inactivated trivalent influenza vaccine in adults 50-80 years of age SO HUMAN VACCINES & IMMUNOTHERAPEUTICS LA English DT Article DE Human influenza; antibodies; immune response; immunogenicity ID UNITED-STATES; SEASONAL INFLUENZA; ADAMANTANE RESISTANCE; IMMUNE-RESPONSE; VIRUS; HUMANS; MEMORY; HOSPITALIZATIONS; IMMUNOGENICITY; IMMUNIZATION AB Background: Concerns about influenza vaccine effectiveness in older adults and the role of influenza strains encountered earlier in life led to this study. Methods: Antibody responses against antigens in the 2011-2012 influenza vaccine at 21 days post vaccination were analyzed in 264 individuals aged 50-80 years. At Days 0 and 21, sera were tested for hemagglutination-inhibition titers against these vaccine strains and at Day 0 against a panel of 15 historical seasonal strains. Results: The proportions of participants with seroprotective titers >= 1:40 to the vaccine strains at Days 0 and 21, respectively, were 37% and 66% for A(H1N1) and 28% and 63% for A(H3N2). An increasing number of responses >= 1.40 against historical strains was associated with seroprotective responses after vaccination among participants with a titer <1.40 at Day 0 for A(H1N1) and A(H3N2) vaccine strains (P < 0.01). In multivariable regression analyses among those with Day 0 titer <1.40, after controlling for age, sex, race, site and diabetes, Day 21 titers >= 1.40 for the vaccine A strains were significantly more likely as the number of seroprotective responses against historical strains increased (A(H1N1) odds ratio [OR] = 1.41, 95% confidence interval [CI] = 1.09-1.82 and A(H3N2) OR = 1.32, 95% CI = 1.07-1.62). The likelihood of seroconversion was significantly higher with an increasing number of responses to historical strains for A(H3N2) only (OR = 1.24, 95% CI = 1.01-1.52). Seroconversion was significantly less likely as Day 0 vaccine strain titers increased. Conclusions: Seroprotective titers after influenza vaccination increased as the number of responses to historical strains increased. C1 [Ross, Ted M.; Bloom, Chalise E.] Univ Pittsburgh, Ctr Vaccine Res, Pittsburgh, PA USA. [Lin, Chyongchiou Jeng; Nowalk, Mary Patricia; Huang, Hsin-Hui; Zimmerman, Richard K.] Univ Pittsburgh, Sch Med, Dept Family Med, Pittsburgh, PA 15260 USA. [Sundaram, Maria E.] Marshfield Clin Res Fdn, Marshfield, WI USA. [Friedrich, Thomas] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA. [Spencer, Sarah M.; Shay, David K.; Sambhara, Suryaprakash] NCIRD, Influenza Div, Ctr Dis Control & Prevent, Atlanta, GA USA. [Ross, Ted M.; Bloom, Chalise E.] Vaccine & Gene Therapy Inst Florida, Port Saint Lucie, FL USA. [Sauereisen, Sandy] UPMC St Margarets Family Med Residency, Pittsburgh, PA USA. [Friedrich, Thomas] Wisconsin Natl Primate Res Ctr, Madison, WI USA. RP Zimmerman, RK (reprint author), Univ Pittsburgh, Sch Med, Dept Family Med, Pittsburgh, PA 15260 USA. EM zimmer@pitt.edu OI Shay, David/0000-0001-9619-4820; Zimmerman, Richard/0000-0001-5941-6092 FU Centers for Disease Control and Prevention [U01 IP000467]; US Department of Energy; CDC FX This investigation was supported by cooperative agreement U01 IP000467 from the Centers for Disease Control and Prevention. The findings and conclusions in this report are those of those authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. This research was also supported in part by an appointment to the Research Participation Program at the Centers for Disease Control and Prevention administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and CDC. NR 33 TC 5 Z9 5 U1 0 U2 1 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 2164-5515 EI 2164-554X J9 HUM VACC IMMUNOTHER JI Human Vaccines Immunother. PD MAY PY 2014 VL 10 IS 5 BP 1195 EP 1203 DI 10.4161/hv.28313 PG 9 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA AI2AA UT WOS:000336656700017 PM 24614078 ER PT J AU Kutty, PK Lawler, J Rausch-Phung, E Ortega-Sanchez, IR Goodell, S Schulte, C Pollock, L Valure, B Hudson, J Gallagher, K Blog, D AF Kutty, Preeta Krishnan Lawler, Jacqueline Rausch-Phung, Elizabeth Ortega-Sanchez, Ismael R. Goodell, Stephen Schulte, Cynthia Pollock, Lynn Valure, Barbara Hudson, Jean Gallagher, Kathleen Blog, Debra TI Epidemiology and the economic assessment of a mumps outbreak in a highly vaccinated population, Orange County, New York, 2009-2010 SO HUMAN VACCINES & IMMUNOTHERAPEUTICS LA English DT Article DE mumps; outbreak; economic; vaccine; highly vaccinated ID RUBELLA MMR VACCINATIONS; UNITED-STATES; UNIVERSITY-STUDENTS; NOTIFIABLE DISEASES; MEASLES; TRANSMISSION; PERSISTENCE; ANTIBODIES; FAILURE; IMPACT AB Studies assessing the economic burden of a mumps outbreak in a highly vaccinated population are limited. The Orange County Health Department (OCHD), New York State Department of Health (NYS DOH), and the Centers for Disease Control and Prevention conducted a mumps investigation in an affected village with a highly vaccinated population. To understand the epidemiology, standardized mumps case definition and active surveillance were used to identify mumps cases. In addition, an economic assessment of a combined outbreak investigation and third dose measles-mumps-rubella (MMR) vaccine intervention conducted by OCHD and NYS DOH was performed; estimated by retrospectively evaluating public health response-related activities including use of a third dose of MMR vaccine. From September 24, 2009, through June 15, 2010, 790 mumps cases were reported-64% were male and highest attack rate was among 11-17 year age group (99.1 cases per 1000 individuals). Of the 658 cases with known vaccination history, 83.6% had documentation of 2 doses of mumps containing vaccine. No deaths were reported. The 2 major exposure settings were schools (71.8%) and households (22.5%). Approximately 7736 h of public health personnel time were expended with the total approximate cost of US $463 000, including US $34 392 for MMR vaccine-the estimated cost per household was US $827. Mumps continues to be endemic in many parts of the world, resulting in importations into the United States. Large mumps outbreaks similar to this in highly vaccinated populations may require considerable investigation and control activities. C1 [Kutty, Preeta Krishnan; Ortega-Sanchez, Ismael R.; Gallagher, Kathleen] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Lawler, Jacqueline; Goodell, Stephen; Valure, Barbara; Hudson, Jean] Orange Cty Hlth Dept, Goshen, NY USA. [Rausch-Phung, Elizabeth; Schulte, Cynthia; Pollock, Lynn; Blog, Debra] New York State Dept Hlth, Bur Immunizat, Albany, NY USA. RP Kutty, PK (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM pkutty@cdc.gov NR 51 TC 3 Z9 3 U1 4 U2 11 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 2164-5515 EI 2164-554X J9 HUM VACC IMMUNOTHER JI Human Vaccines Immunother. PD MAY PY 2014 VL 10 IS 5 BP 1373 EP 1381 DI 10.4161/hv.28389 PG 9 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA AI2AA UT WOS:000336656700041 PM 24633360 ER PT J AU Geller, AI Shehab, N Lovegrove, MC Kegler, SR Weidenbach, KN Ryan, GJ Budnitz, DS AF Geller, Andrew I. Shehab, Nadine Lovegrove, Maribeth C. Kegler, Scott R. Weidenbach, Kelly N. Ryan, Gina J. Budnitz, Daniel S. TI National Estimates of Insulin-Related Hypoglycemia and Errors Leading to Emergency Department Visits and Hospitalizations SO JAMA INTERNAL MEDICINE LA English DT Article ID TYPE-2 DIABETES-MELLITUS; INDIVIDUALIZING GLYCEMIC TARGETS; ADVERSE DRUG EVENTS; MEDICAL-SERVICES; QUALITY MEASURES; GLUCOSE-CONTROL; CARE; MANAGEMENT; IMPACT; ADULTS AB IMPORTANCE Detailed, nationally representative data describing high-risk populations and circumstances involved in insulin-related hypoglycemia and errors (IHEs) can inform approaches to individualizing glycemic targets. OBJECTIVE To describe the US burden, rates, and characteristics of emergency department (ED) visits and emergency hospitalizations for IHEs. DESIGN, SETTING, AND PARTICIPANTS Nationally representative public health surveillance of adverse drug events among insulin-treated patients seeking ED care (National Electronic Injury Surveillance System-Cooperative Adverse Drug Event Surveillance project) and a national household survey of insulin use (the National Health Interview Survey) were used to obtain data from January 1, 2007, through December 31, 2011. MAIN OUTCOMES AND MEASURES Estimated annual numbers and estimated annual rates of ED visits and hospitalizations for IHEs among insulin-treated patients with diabetes mellitus. RESULTS Based on 8100 National Electronic Injury Surveillance System-Cooperative Adverse Drug Event Surveillance cases, an estimated 97 648 (95% CI, 64 410-130 887) ED visits for IHEs occurred annually; almost one-third (29.3%; 95% CI, 21.8%-36.8%) resulted in hospitalization. Severe neurologic sequelae were documented in an estimated 60.6%(95% CI, 51.3%-69.9%) of ED visits for IHEs, and blood glucose levels of 50 mg/dL (to convert to millimoles per liter, multiply by 0.0555) or less were recorded in more than half of cases (53.4%). Insulin-treated patients 80 years or older were more than twice as likely to visit the ED (rate ratio, 2.5; 95% CI, 1.5-4.3) and nearly 5 times as likely to be subsequently hospitalized (rate ratio, 4.9; 95% CI, 2.6-9.1) for IHEs than those 45 to 64 years. The most commonly identified IHE precipitants were reduced food intake and administration of the wrong insulin product. CONCLUSIONS AND RELEVANCE Rates of ED visits and subsequent hospitalizations for IHEs were highest in patients 80 years or older; the risks of hypoglycemic sequelae in this age group should be considered in decisions to prescribe and intensify insulin. Meal-planning misadventures and insulin product mix-ups are important targets for hypoglycemia prevention efforts. C1 [Geller, Andrew I.; Shehab, Nadine; Lovegrove, Maribeth C.; Budnitz, Daniel S.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. [Kegler, Scott R.] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Div Anal Res & Practice Integrat, Atlanta, GA 30333 USA. [Weidenbach, Kelly N.] SRA Int, Atlanta, GA USA. [Ryan, Gina J.] Mercer Univ, Coll Pharm & Hlth Sci, Atlanta, GA USA. RP Geller, AI (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, 1600 Clifton Rd NE,Mail Stop A-24, Atlanta, GA 30333 USA. EM AGeller@cdc.gov FU Intramural CDC HHS [CC999999] NR 68 TC 52 Z9 52 U1 3 U2 12 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD MAY PY 2014 VL 174 IS 5 BP 678 EP 686 DI 10.1001/jamainternmed.2014.136 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA AI4NS UT WOS:000336842700007 PM 24615164 ER PT J AU Baumblatt, JAG Wiedeman, C Dunn, JR Schaffner, W Paulozzi, LJ Jones, TF AF Baumblatt, Jane A. Gwira Wiedeman, Caleb Dunn, John R. Schaffner, William Paulozzi, Leonard J. Jones, Timothy F. TI High-Risk Use by Patients Prescribed Opioids for Pain and Its Role in Overdose Deaths SO JAMA INTERNAL MEDICINE LA English DT Article ID PRESCRIPTION DRUG OVERDOSES; UNITED-STATES; ABUSE; ANALGESICS; DIVERSION; MORTALITY; EPIDEMIC AB IMPORTANCE From January 1, 2003, through December 31, 2010, drug overdose deaths in Tennessee increased from 422 to 1059 per year. More of these deaths involved prescription opioids than heroin and cocaine combined. OBJECTIVE To assess the contribution of certain opioid-prescribing patterns to the risk of overdose death. DESIGN, SETTING, AND PARTICIPANTS We performed a matched case-control study that analyzed opioid prescription data from the Tennessee Controlled Substances Monitoring Program (TNCSMP) from January 1, 2007, through December 31, 2011, to identify risk factors associated with opioid-related overdose deaths from January 1, 2009, through December 31, 2010. Case patients were ascertained from death certificate data. Age-and sex-matched controls were randomly selected from among live patients in the TNCSMP. MAIN OUTCOMES AND MEASURES We defined a high-risk number of prescribers or pharmacies as 4 or more per year and high-risk dosage as a daily mean of more than 100 morphine milligram equivalents (MMEs) per year. The main outcome was opioid-related overdose death. RESULTS From January 1, 2007, through December 31, 2011, one-third of the population of Tennessee filled an opioid prescription each year, and opioid prescription rates increased from 108.3 to 142.5 per 100 population per year. Among all patients in Tennessee prescribed opioids during 2011, 7.6% used more than 4 prescribers, 2.5% used more than 4 pharmacies, and 2.8% had a mean daily dosage greater than 100 MMEs. Increased risk of opioid-related overdose death was associated with 4 or more prescribers (adjusted odds ratio [aOR], 6.5; 95% CI, 5.1-8.5), 4 or more pharmacies (aOR, 6.0; 95% CI, 4.4-8.3), and more than 100 MMEs (aOR, 11.2; 95% CI, 8.3-15.1). Persons with 1 or more risk factor accounted for 55% of all overdose deaths. CONCLUSIONS AND RELEVANCE High-risk use of prescription opioids is frequent and increasing in Tennessee and is associated with increased overdose mortality. Use of prescription drug-monitoring program data to direct risk-reduction measures to the types of patients overrepresented among overdose deaths might reduce mortality associated with opioid abuse. C1 [Baumblatt, Jane A. Gwira] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Tennessee Dept Hlth, Nashville, TN USA. [Wiedeman, Caleb; Dunn, John R.; Schaffner, William; Jones, Timothy F.] Tennessee Dept Hlth, Nashville, TN USA. [Dunn, John R.; Schaffner, William] Vanderbilt Univ, Sch Med, Dept Prevent Med & Med, Nashville, TN 37212 USA. [Paulozzi, Leonard J.] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA. RP Baumblatt, JAG (reprint author), Agcy Healthcare Res & Qual, Ctr Qual Improvement & Patient Safety, 540 Gaither Rd, Rockville, MD 20850 USA. NR 31 TC 44 Z9 44 U1 4 U2 12 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD MAY PY 2014 VL 174 IS 5 BP 796 EP 801 DI 10.1001/jamainternmed.2013.12711 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA AI4NS UT WOS:000336842700028 ER PT J AU Jones, CM Paulozzi, LJ Mack, KA AF Jones, Christopher M. Paulozzi, Leonard J. Mack, Karin A. TI Sources of Prescription Opioid Pain Relievers by Frequency of Past-Year Nonmedical Use: United States, 2008-2011 SO JAMA INTERNAL MEDICINE LA English DT Letter C1 [Jones, Christopher M.; Paulozzi, Leonard J.; Mack, Karin A.] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA. RP Jones, CM (reprint author), Ctr Dis Control & Prevent, Chamblee Campus,4770 Buford Hwy NE,MS F-62, Atlanta, GA 30341 USA. EM fjr0@cdc.gov RI Mack, Karin/A-3263-2012 OI Mack, Karin/0000-0001-9274-3001 NR 6 TC 33 Z9 34 U1 2 U2 5 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD MAY PY 2014 VL 174 IS 5 BP 802 EP 803 DI 10.1001/jamainternmed.2013.12809 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA AI4NS UT WOS:000336842700029 PM 24589763 ER PT J AU Alexander, KT Oduor, C Nyothach, E Laserson, KF Amek, N Eleveld, A Mason, L Rheingans, R Beynon, C Mohammed, A Ombok, M Obor, D Odhiambo, F Quick, R Phillips-Howard, PA AF Alexander, Kelly T. Oduor, Clifford Nyothach, Elizabeth Laserson, Kayla F. Amek, Nyaguara Eleveld, Alie Mason, Linda Rheingans, Richard Beynon, Caryl Mohammed, Aisha Ombok, Maurice Obor, David Odhiambo, Frank Quick, Robert Phillips-Howard, Penelope A. TI Water, Sanitation and Hygiene Conditions in Kenyan Rural Schools: Are Schools Meeting the Needs of Menstruating Girls? SO WATER LA English DT Article DE school; education; children; water sanitation and hygiene; NGOs; Africa; Kenya; menstruation ID CLUSTER-RANDOMIZED TRIAL; WESTERN KENYA; NYANZA PROVINCE; SAFE WATER; HEALTH; IMPACT; PROGRAM; RISK; EXPERIENCES; PREVENTION AB Water, sanitation and hygiene (WASH) programs in African schools have received increased attention, particularly around the potential impact of poor menstrual hygiene management (MHM) on equity for girls' education. This study was conducted prior to a menstrual feasibility study in rural Kenya, to examine current WASH in primary schools and the resources available for menstruating schoolgirls. Cross-sectional surveys were performed in 62 primary schools during unannounced visits. Of these, 60% had handwashing water, 13% had washing water in latrines for menstruating girls, and 2% had soap. Latrines were structurally sound and 16% were clean. Most schools (84%) had separate latrines for girls, but the majority (77%) had no lock. Non-governmental organizations (NGOs) supported WASH in 76% of schools. Schools receiving WASH interventions were more likely to have: cleaner latrines (Risk Ratio (RR) 1.5; 95% Confidence Intervals [CI] 1.0, 2.1), handwashing facilities (RR 1.6, CI 1.1, 2.5), handwashing water (RR 2.7; CI 1.4, 5.2), and water in girls' latrines (RR 4.0; CI 1.4, 11.6). Schools continue to lack essential WASH facilities for menstruating girls. While external support for school WASH interventions improved MHM quality, the impact of these contributions remains insufficient. Further support is required to meet international recommendations for healthy, gender-equitable schools. C1 [Alexander, Kelly T.; Mason, Linda; Phillips-Howard, Penelope A.] Univ Liverpool Liverpool Sch Trop Med, Dept Clin Studies, Liverpool L3 5QA, Merseyside, England. [Oduor, Clifford; Nyothach, Elizabeth; Laserson, Kayla F.; Amek, Nyaguara; Ombok, Maurice; Obor, David; Odhiambo, Frank; Phillips-Howard, Penelope A.] Ctr Global Hlth Res, Kenya Med Res Inst, Kisumu 157840100, Kenya. [Laserson, Kayla F.] Ctr Dis Control & Prevent, Ctr Global Hlth, Atlanta, GA 30333 USA. [Eleveld, Alie] Safe Water & AIDS Project, Kisumu 40100, Kenya. [Rheingans, Richard] Univ Florida, Dept Environm & Global Hlth, Gainesville, FL 32611 USA. [Rheingans, Richard] Univ Florida, Ctr African Studies, Gainesville, FL 32611 USA. [Beynon, Caryl] Liverpool John Moores Univ, Ctr Publ Hlth, Liverpool L3 2ET, Merseyside, England. [Mohammed, Aisha] Minist Publ Hlth & Sanitat, Nairobi 10100, Kenya. [Quick, Robert] Ctr Dis Control & Prevent, Waterborne Dis Prevent Branch, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. RP Alexander, KT (reprint author), Univ Liverpool Liverpool Sch Trop Med, Dept Clin Studies, Liverpool L3 5QA, Merseyside, England. EM kelly.alexander@liverpool.ac.uk; COduor@kemricdc.org; ENyothach@kemricdc.org; kel4@cdc.gov; NAmek@kemricdc.org; alie@swapkenya.org; linda.mason@liverpool.ac.uk; rrheing@epi.ufl.edu; carylbeynon@hotmail.co.uk; a_o_mohamed@yahoo.com; MOmbok@kemricdc.org; DObor@kemricdc.org; fodhiambo@kemricdc.org; rxq1@cdc.gov.org; P.Phillips-Howard@liverpool.ac.uk FU UK Medical Research Council/Department for International Development/Wellcome Trust [G1100677/1]; British Council's Prime Ministers Initiative FX This study is part of the preliminary phase of a proof of concept feasibility study on menstrual solutions for schoolgirls funded by the UK Medical Research Council/Department for International Development/Wellcome Trust Project Protect (G1100677/1). We received seed funding through the British Council's Prime Ministers Initiative (2) for workshops on the overlap between water and sanitation and sexual and reproductive health, supporting collaboration with UK and US universities, and local partners. Funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 47 TC 9 Z9 9 U1 4 U2 33 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2073-4441 J9 WATER-SUI JI Water PD MAY PY 2014 VL 6 IS 5 BP 1453 EP 1466 DI 10.3390/w6051453 PG 14 WC Water Resources SC Water Resources GA AI7WV UT WOS:000337113600018 ER PT J AU Will, JC Yuan, KM Ford, E AF Will, Julie C. Yuan, Keming Ford, Earl TI National Trends in the Prevalence and Medical History of Angina: 1988 to 2012 SO CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES LA English DT Article DE epidemiology; medical history; prevalence; trends ID CORONARY-HEART-DISEASE; ACUTE MYOCARDIAL-INFARCTION; UNITED-STATES; US ADULTS; CARDIOVASCULAR-DISEASE; CASE-FATALITY; RISK; HYPERTENSION; OBESITY; QUESTIONNAIRE AB Background-The prevalence of angina from 1971 to 1994 was relatively flat for whites and blacks. We ask whether the prevalence and medical history of angina have changed during 1988 to 2012. Methods and Results-We used the National Health and Nutrition Examination Survey data from 1988 to 2004 and the data from the six 2-year surveys from 2001 to 2012. We calculated trends in both crude and standardized prevalence rates for the Rose questionnaire on angina (symptomatology) and a question asking whether the respondent had ever been told by a medical professional that they had angina (medical history). In 2009 to 2012, there were on average 3.4 million (95% confidence interval, 2.8-4.0 million) people aged >= 40 years in the United States each year with angina (Rose questionnaire) and 4.5 million (95% confidence interval, 3.5-5.1 million) people with a medical history of angina. The burden of angina varied across age, race, and sex categories, and the pattern of variation differed by whether symptomatology or medical history was assessed. Statistically significant declines in the rates for both outcomes were noted, for the most part, in people aged >= 65 years. Age and sex standardized rates declined significantly for whites but not for blacks. Conclusions-Rates of angina symptoms and medical history of angina have declined among non-Hispanic whites and among adults aged >= 65 years. Blacks have not experienced these same declines. Clearly, additional study is required to understand these declines and to track the future cost and burden of angina in the US population. C1 [Will, Julie C.; Yuan, Keming] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA 30341 USA. [Ford, Earl] Ctr Dis Control & Prevent, Div Populat Hlth, Atlanta, GA 30341 USA. RP Will, JC (reprint author), Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, 4770 Buford Hwy NE,Mailstop F-72, Atlanta, GA 30341 USA. EM jxw6@cdc.gov FU Intramural CDC HHS [CC999999] NR 32 TC 7 Z9 8 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1941-7705 EI 1941-7713 J9 CIRC-CARDIOVASC QUAL JI Circ.-Cardiovasc. Qual. Outcomes PD MAY PY 2014 VL 7 IS 3 BP 407 EP 413 DI 10.1161/CIRCOUTCOMES.113.000779 PG 7 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA AI3WQ UT WOS:000336796300010 PM 24847083 ER PT J AU Coon, CD Lau, DT AF Coon, Cheryl D. Lau, Denys T. TI Informing Drug Development and Clinical Practice Through Patient-Centered Outcomes Research SO CLINICAL THERAPEUTICS LA English DT Editorial Material C1 [Lau, Denys T.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Lau, Denys T.] Univ Illinois, Coll Pharm, Chicago, IL USA. NR 7 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER PI BRIDGEWATER PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA SN 0149-2918 EI 1879-114X J9 CLIN THER JI Clin. Ther. PD MAY PY 2014 VL 36 IS 5 BP 616 EP 618 DI 10.1016/j.clinthera.2014.04.015 PG 3 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA AI3QY UT WOS:000336778200002 PM 24852594 ER PT J AU Hopf, NB Ruder, AM Succop, P Waters, MA AF Hopf, Nancy B. Ruder, Avima M. Succop, Paul Waters, Martha A. TI Evaluation of cumulative PCB exposure estimated by a job exposure matrix versus PCB serum concentrations SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH LA English DT Article; Proceedings Paper CT 7th International PCB Workshop - Chemical mixtures in a complex world CY MAY 27-31, 2012 CL Arcachon, FRANCE DE Polychlorinated biphenyls; PCB; Serum PCB; Aroclor; Occupational exposure ID POLYCHLORINATED-BIPHENYLS PCBS; CAPACITOR MANUFACTURING WORKERS; OCCUPATIONAL-EXPOSURE; HALF-LIVES; DERMAL ABSORPTION; MORTALITY; CONGENERS; PERSISTENCE; PLANT; RISK AB Although polychlorinated biphenyls (PCBs) have been banned in many countries for more than three decades, exposures to PCBs continue to be of concern due to their long half-lives and carcinogenic effects. In National Institute for Occupational Safety and Health studies, we are using semiquantitative plant-specific job exposure matrices (JEMs) to estimate historical PCB exposures for workers (n = 24,865) exposed to PCBs from 1938 to 1978 at three capacitor manufacturing plants. A subcohort of these workers (n = 410) employed in two of these plants had serum PCB concentrations measured at up to four times between 1976 and 1989. Our objectives were to evaluate the strength of association between an individual worker's measured serum PCB levels and the same worker's cumulative exposure estimated through 1977 with the (1) JEM and (2) duration of employment, and to calculate the explained variance the JEM provides for serum PCB levels using (3) simple linear regression. Consistent strong and statistically significant associations were observed between the cumulative exposures estimated with the JEM and serum PCB concentrations for all years. The strength of association between duration of employment and serum PCBs was good for highly chlorinated (Aroclor 1254/HPCB) but not less chlorinated (Aroclor 1242/LPCB) PCBs. In the simple regression models, cumulative occupational exposure estimated using the JEMs explained 14-24 % of the variance of the Aroclor 1242/LPCB and 22-39 % for Aroclor 1254/HPCB serum concentrations. We regard the cumulative exposure estimated with the JEM as a better estimate of PCB body burdens than serum concentrations quantified as Aroclor 1242/LPCB and Aroclor 1254/HPCB. C1 [Hopf, Nancy B.] Inst Work & Hlth IST, CH-1066 Epalinges, Switzerland. [Ruder, Avima M.; Waters, Martha A.] NIOSH, Ctr Dis Control & Prevent, CDC, Cincinnati, OH 45226 USA. [Succop, Paul] Univ Cincinnati, Dept Environm Hlth, Cincinnati, OH 45267 USA. RP Hopf, NB (reprint author), Inst Work & Hlth IST, Route Corniche 2, CH-1066 Epalinges, Switzerland. EM Nancy.Hopf@hospvd.ch; amr2@cdc.gov; succopa@uc.edu; maw0@cdc.gov FU Intramural CDC HHS [CC999999] NR 47 TC 1 Z9 1 U1 3 U2 6 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0944-1344 EI 1614-7499 J9 ENVIRON SCI POLLUT R JI Environ. Sci. Pollut. Res. PD MAY PY 2014 VL 21 IS 10 BP 6314 EP 6323 DI 10.1007/s11356-013-1574-4 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA AH7LO UT WOS:000336314900006 PM 23475397 ER PT J AU Hopf, NB Ruder, AM Waters, MA AF Hopf, Nancy B. Ruder, Avima M. Waters, Martha A. TI Historical reconstruction of polychlorinated biphenyl (PCB) exposures for workers in a capacitor manufacturing plant SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH LA English DT Article; Proceedings Paper CT 7th International PCB Workshop - Chemical mixtures in a complex world CY MAY 27-31, 2012 CL Arcachon, FRANCE DE Polychlorinated biphenyls (PCB); Job exposure matrix (JEM) ID HUMAN CANCER-RISKS; OCCUPATIONAL-EXPOSURE; DERMAL ABSORPTION; MATRIX TEM; MORTALITY; UPDATE; MISCLASSIFICATION; AGENTS AB We developed a semiquantitative job exposure matrix (JEM) for workers exposed to polychlorinated biphenyls (PCBs) at a capacitor manufacturing plant from 1946 to 1977. In a recently updated mortality study, mortality of prostate and stomach cancer increased with increasing levels of cumulative exposure estimated with this JEM (trend p values=0.003 and 0.04, respectively). Capacitor manufacturing began with winding bales of foil and paper film, which were placed in a metal capacitor box (pre-assembly), and placed in a vacuum chamber for flood-filling (impregnation) with dielectric fluid (PCBs). Capacitors dripping with PCB residues were then transported to sealing stations where ports were soldered shut before degreasing, leak testing, and painting. Using a systematic approach, all 509 unique jobs identified in the work histories were rated by predetermined process- and plant-specific exposure determinants; then categorized based on the jobs' similarities (combination of exposure determinants) into 35 job exposure categories. The job exposure categories were ranked followed by a qualitative PCB exposure rating (baseline, low, medium, and high) for inhalation and dermal intensity. Category differences in other chemical exposures (solvents, etc.) prevented further combining of categories. The mean of all available PCB concentrations (1975 and 1977) for jobs within each intensity rating was regarded as a representative value for that intensity level. Inhalation (in microgram per cubic milligram) and dermal (unitless) exposures were regarded as equally important. Intensity was frequency adjusted for jobs with continuous or intermittent PCB exposures. Era-modifying factors were applied to the earlier time periods (1946-1974) because exposures were considered to have been greater than in later eras (1975-1977). Such interpolations, extrapolations, and modifying factors may introduce non-differential misclassification; however, we do believe our rigorous method minimized misclassification, as shown by the significant exposure-response trends in the epidemiologic analysis. C1 [Hopf, Nancy B.] Inst Work & Hlth IST, CH-1066 Epalinges, Switzerland. [Ruder, Avima M.; Waters, Martha A.] NIOSH, Ctr Dis Control & Prevent CDC, Cincinnati, OH 45226 USA. RP Hopf, NB (reprint author), Inst Work & Hlth IST, Route Corniche 2, CH-1066 Epalinges, Switzerland. EM Nancy.Hopf@hospvd.ch; amr2@cdc.gov; maw0@cdc.gov FU Intramural CDC HHS [CC999999] NR 49 TC 3 Z9 3 U1 2 U2 9 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0944-1344 EI 1614-7499 J9 ENVIRON SCI POLLUT R JI Environ. Sci. Pollut. Res. PD MAY PY 2014 VL 21 IS 10 BP 6419 EP 6433 DI 10.1007/s11356-013-1590-4 PG 15 WC Environmental Sciences SC Environmental Sciences & Ecology GA AH7LO UT WOS:000336314900016 PM 23475444 ER PT J AU Okoro, CA Dhingra, SS Li, CY AF Okoro, Catherine A. Dhingra, Satvinder S. Li, Chaoyang TI A Triple Play: Psychological Distress, Physical Comorbidities, and Access and Use of Health Services among US Adults with Disabilities SO JOURNAL OF HEALTH CARE FOR THE POOR AND UNDERSERVED LA English DT Article DE Psychological distress; mental health; disability; BRFSS; surveillance ID SERIOUS MENTAL-ILLNESS; FACTOR SURVEILLANCE SYSTEM; ASSISTIVE TECHNOLOGY; GENERAL-POPULATION; HURRICANE KATRINA; SCREENING SCALES; INTERVIEW SURVEY; NATIONAL-HEALTH; UNITED-STATES; OLDER-ADULTS AB Purpose. Among adults with disabilities, we examined whether increasing levels of psychological distress were associated with higher estimated prevalences of chronic conditions, obesity, health care access, and use of preventive services. Methods. We analyzed data from the 2007 Behavioral Risk Factor Surveillance System. The Kessler-6 scale was used to assess psychological distress. Results. Increasing levels of psychological distress were associated with an increased prevalence of chronic diseases and conditions, and decreased access to health care and utilization of preventive services in keeping with what has been established for non-disabled populations. Among adults with disabilities, aged 18-64 years and 65 years or older, increasing levels of distress were also associated with increased receipt of mental health treatment. However, compared to adults aged 18-64 years, larger proportions of older adults reported non-receipt of mental health treatment (mild to moderate psychological distress: 58.0% versus 70.6%; serious psychological distress: 40.5% versus 54.5%). Conclusions. While adults with disabilities who had increased levels of psychological distress were more likely to receive mental health services, they also had higher estimated prevalences of chronic conditions, barriers to health care, and non-receipt of preventive cancer screenings. C1 [Okoro, Catherine A.; Dhingra, Satvinder S.; Li, Chaoyang] Ctr Dis Control & Prevent, Div Behav Surveillance, Publ Hlth Surveillance & Informat Program Off, Off Surveillance Epidemiol & Lab Serv, Atlanta, GA 30333 USA. RP Okoro, CA (reprint author), Ctr Dis Control & Prevent, Div Behav Surveillance, Publ Hlth Surveillance & Informat Program Off, Off Surveillance Epidemiol & Lab Serv, 1600 Clifton Rd NE,M-S E-97, Atlanta, GA 30333 USA. EM COkoro@cdc.gov NR 64 TC 2 Z9 2 U1 9 U2 18 PU JOHNS HOPKINS UNIV PRESS PI BALTIMORE PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD 21218-4363 USA SN 1049-2089 EI 1548-6869 J9 J HEALTH CARE POOR U JI J. Health Care Poor Underserved PD MAY PY 2014 VL 25 IS 2 BP 814 EP 836 PG 23 WC Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA AH7VJ UT WOS:000336343100030 PM 24858888 ER PT J AU Wang, GJ Zhang, ZF Ayala, C Dunet, DO Fang, J George, MG AF Wang, Guijing Zhang, Zefeng Ayala, Carma Dunet, Diane O. Fang, Jing George, Mary G. TI Costs of Hospitalization for Stroke Patients Aged 18-64 Years in the United States SO JOURNAL OF STROKE & CEREBROVASCULAR DISEASES LA English DT Article DE Cost; stroke type; diagnosis type; comorbidity ID ACUTE ISCHEMIC-STROKE; HIP FRACTURE; DISEASE; CONSEQUENCES; POPULATION; DIAGNOSIS; OUTCOMES; BURDEN; CARE; ICD-9-CM AB Background: Estimates for the average cost of stroke have varied 20-fold in the United States. To provide a robust cost estimate, we conducted a comprehensive analysis of the hospitalization costs for stroke patients by diagnosis status and event type. Methods: Using the 2006-2008 MarketScan inpatient database, we identified 97,374 hospitalizations with a primary or secondary diagnosis of stroke. We analyzed the costs after stratifying the hospitalizations by stroke type (hemorrhagic, ischemic, and other strokes) and diagnosis status (primary and secondary). We employed regressions to estimate the impact of event type and diagnosis status on costs while controlling for major potential confounders. Results: Among the 97,374 hospitalizations (average cost: $20,396 +/- $23,256), the number with ischemic, hemorrhagic, or other strokes was 62,637, 16,331, and 48,208, respectively, with these types having average costs, in turn, of $18,963 +/- $21,454, $32,035 +/- $32,046, and $19,248 +/- $21,703. A majority (62%) of the hospitalizations had stroke listed as a secondary diagnosis only. Regression analysis found that, overall, hemorrhagic stroke cost $14,499 more than ischemic stroke (P < .001). For hospitalizations with a primary diagnosis of ischemic stroke, those with a secondary diagnosis of ischemic heart disease (IHD) had costs that were $9836 higher (P < .001) than those without IHD. Conclusions: The costs of hospitalizations involving stroke are high and vary greatly by type of stroke, diagnosis status, and comorbidities. These findings should be incorporated into cost-effective strategies to reduce the impact of stroke. C1 [Wang, Guijing; Zhang, Zefeng; Ayala, Carma; Dunet, Diane O.; Fang, Jing; George, Mary G.] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA 30341 USA. RP Wang, GJ (reprint author), Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, 4770 Buford Hwy,MS F-72, Atlanta, GA 30341 USA. EM Gbw9@cdc.gov FU Intramural CDC HHS [CC999999] NR 43 TC 11 Z9 11 U1 0 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1052-3057 EI 1532-8511 J9 J STROKE CEREBROVASC JI J. Stroke Cerebrovasc. Dis. PD MAY-JUN PY 2014 VL 23 IS 5 BP 861 EP 868 DI 10.1016/j.jstrokecerebrovasdis.2013.07.017 PG 8 WC Neurosciences; Peripheral Vascular Disease SC Neurosciences & Neurology; Cardiovascular System & Cardiology GA AH9SI UT WOS:000336482000027 PM 23954598 ER PT J AU Fry, AM AF Fry, Alicia M. TI Effectiveness of neuraminidase inhibitors for severe influenza SO LANCET RESPIRATORY MEDICINE LA English DT Editorial Material ID RANDOMIZED CONTROLLED-TRIAL; SEASONAL INFLUENZA; OSELTAMIVIR; CHILDREN C1 Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Fry, AM (reprint author), Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM afry@cdc.gov NR 10 TC 1 Z9 1 U1 1 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 2213-2600 J9 LANCET RESP MED JI Lancet Resp. Med. PD MAY PY 2014 VL 2 IS 5 BP 346 EP 348 DI 10.1016/S2213-2600(14)70068-2 PG 4 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA AI2VN UT WOS:000336716300008 PM 24815800 ER PT J AU Muthuri, SG Venkatesan, S Myles, PR Leonardi-Bee, J Al Khuwaitir, TSA Al Mamun, A Anovadiya, AP Azziz-Baumgartner, E Baez, C Bassetti, M Beovic, B Bertisch, B Bonmarin, I Booy, R Borja-Aburto, VH Burgmann, H Cao, B Carratala, J Denholm, JT Dominguez, SR Duarte, PAD Dubnov-Raz, G Echavarria, M Fanella, S Gao, ZC Gerardin, P Giannella, M Gubbels, S Herberg, J Iglesias, ALH Hoger, PH Hu, XY Islam, QT Jimenez, MF Kandeel, A Keijzers, G Khalili, H Knight, M Kudo, K Kusznierz, G Kuzman, I Kwan, AMC Amine, IL Langenegger, E Lankarani, KB Leo, YS Linko, R Liu, P Madanat, F Mayo-Montero, E McGeer, A Memish, Z Metan, G Mickiene, A Mikic, D Mohn, KGI Moradi, A Nymadawa, P Oliva, ME Ozkan, M Parekh, D Paul, M Polack, FP Rath, BA Rodriguez, AH Sarrouf, EB Seale, AC Sertogullarindan, B Siqueira, MM Skret-Magierlo, J Stephan, F Talarek, E Tang, JW To, KKW Torres, A Torun, SH Tran, D Uyeki, TM Van Zwol, A Vaudry, W Vidmar, T Yokota, RTC Zarogoulidis, P Nguyen-Van-Tam, JS AF Muthuri, Stella G. Venkatesan, Sudhir Myles, Puja R. Leonardi-Bee, Jo Al Khuwaitir, Tarig S. A. Al Mamun, Adbullah Anovadiya, Ashish P. Azziz-Baumgartner, Eduardo Baez, Clarisa Bassetti, Matteo Beovic, Bojana Bertisch, Barbara Bonmarin, Isabelle Booy, Robert Borja-Aburto, Victor H. Burgmann, Heinz Cao, Bin Carratala, Jordi Denholm, Justin T. Dominguez, Samuel R. Duarte, Pericles A. D. Dubnov-Raz, Gal Echavarria, Marcela Fanella, Sergio Gao, Zhancheng Gerardin, Patrick Giannella, Maddalena Gubbels, Sophie Herberg, Jethro Higuera Iglesias, Anjarath L. Hoger, Peter H. Hu, Xiaoyun Islam, Quazi T. Jimenez, Mirela F. Kandeel, Amr Keijzers, Gerben Khalili, Hossein Knight, Marian Kudo, Koichiro Kusznierz, Gabriela Kuzman, Ilija Kwan, Arthur M. C. Amine, Idriss Lahlou Langenegger, Eduard Lankarani, Kamran B. Leo, Yee-Sin Linko, Rita Liu, Pei Madanat, Faris Mayo-Montero, Elga McGeer, Allison Memish, Ziad Metan, Gokhan Mickiene, Aukse Mikic, Dragan Mohn, Kristin G. I. Moradi, Ahmadreza Nymadawa, Pagbajabyn Oliva, Maria E. Ozkan, Mehpare Parekh, Dhruv Paul, Mical Polack, Fernando P. Rath, Barbara A. Rodriguez, Alejandro H. Sarrouf, Elena B. Seale, Anna C. Sertogullarindan, Bunyamin Siqueira, Marilda M. Skret-Magierlo, Joanna Stephan, Frank Talarek, Ewa Tang, Julian W. To, Kelvin K. W. Torres, Antoni Torun, Selda H. Dat Tran Uyeki, Timothy M. Van Zwol, Annelies Vaudry, Wendy Vidmar, Tjasa Yokota, Renata T. C. Zarogoulidis, Paul Nguyen-Van-Tam, Jonathan S. CA PRIDE Consortium Investigators TI Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data SO LANCET RESPIRATORY MEDICINE LA English DT Article ID STEM-CELL TRANSPLANTATION; PANDEMIC INFLUENZA; ANTIVIRAL TREATMENT; RISK-FACTORS; OSELTAMIVIR; CHILDREN; OUTCOMES; THERAPY; IMPACT; ADULTS AB Background Neuraminidase inhibitors were widely used during the 2009-10 influenza A H1N1 pandemic, but evidence for their effectiveness in reducing mortality is uncertain. We did a meta-analysis of individual participant data to investigate the association between use of neuraminidase inhibitors and mortality in patients admitted to hospital with pandemic influenza A H1N1pdm09 virus infection. Methods We assembled data for patients (all ages) admitted to hospital worldwide with laboratory confirmed or clinically diagnosed pandemic influenza A H1N1pdm09 virus infection. We identified potential data contributors from an earlier systematic review of reported studies addressing the same research question. In our systematic review, eligible studies were done between March 1, 2009 (Mexico), or April 1, 2009 (rest of the world), until the WHO declaration of the end of the pandemic (Aug 10, 2010); however, we continued to receive data up to March 14, 2011, from ongoing studies. We did a meta-analysis of individual participant data to assess the association between neuraminidase inhibitor treatment and mortality (primary outcome), adjusting for both treatment propensity and potential confounders, using generalised linear mixed modelling. We assessed the association with time to treatment using time-dependent Cox regression shared frailty modelling. Findings We included data for 29 234 patients from 78 studies of patients admitted to hospital between Jan 2, 2009, and March 14, 2011. Compared with no treatment, neuraminidase inhibitor treatment (irrespective of timing) was associated with a reduction in mortality risk (adjusted odds ratio [OR] 0.81; 95% CI 0.70-0.93; p=0.0024). Compared with later treatment, early treatment (within 2 days of symptom onset) was associated with a reduction in mortality risk (adjusted OR 0.48; 95% CI 0.41-0.56; p<0.0001). Early treatment versus no treatment was also associated with a reduction in mortality (adjusted OR 0.50; 95% CI 0.37-0.67; p<0.0001). These associations with reduced mortality risk were less pronounced and not significant in children. There was an increase in the mortality hazard rate with each day's delay in initiation of treatment up to day 5 as compared with treatment initiated within 2 days of symptom onset (adjusted hazard ratio [HR 1.23] [95% CI 1.18-1.28]; p<0.0001 for the increasing HR with each day's delay). Interpretation We advocate early instigation of neuraminidase inhibitor treatment in adults admitted to hospital with suspected or proven influenza infection. C1 [Muthuri, Stella G.; Venkatesan, Sudhir; Myles, Puja R.; Leonardi-Bee, Jo; Nguyen-Van-Tam, Jonathan S.] Univ Nottingham, Div Epidemiol & Publ Hlth, Nottingham NG5 1PB, England. [Al Khuwaitir, Tarig S. A.] King Saud Med City, Dept Med, Riyadh, Saudi Arabia. [Al Mamun, Adbullah] Res Bangladesh, Int Ctr Diarrhoeal Dis, Dhaka, Bangladesh. [Anovadiya, Ashish P.] Govt Med Coll Bhavnagar, Dept Pharmacol, Bhavnagar, Gujarat, India. [Anovadiya, Ashish P.] Sir Takhtsinhji Gen Hosp, Bhavnagar, Gujarat, India. [Azziz-Baumgartner, Eduardo] Ctr Dis Control & Prevent, Atlanta, GA USA. [Baez, Clarisa] Minist Salud Prov Buenos Aires, Buenos Aires, DF, Argentina. [Bassetti, Matteo] Santa Maria Misericordia Hosp, Udine, Italy. [Beovic, Bojana] Univ Med Ctr, Dept Infect Dis, Ljubljana, Slovenia. [Bertisch, Barbara] Kantonsspital St Gallen, Div Infect Dis & Hosp Epidemiol, St Gallen, Switzerland. [Bonmarin, Isabelle] Inst Veille Sanit, St Maurice, France. [Booy, Robert] Univ Sydney, Childrens Hosp Westmead, Natl Ctr Immunisat Res & Surveillance, Sydney, NSW 2006, Australia. [Borja-Aburto, Victor H.] Inst Mexicano Seguro Social, Mexico City, DF, Mexico. [Burgmann, Heinz] Med Univ Vienna, Vienna, Austria. [Cao, Bin] Capital Med Univ, Beijing Chao Yang Hosp, Beijing, Peoples R China. [Carratala, Jordi] Univ Barcelona, Bellvitge Inst Biomed Res, Hosp Univ Bellvitge, Dept Infect Dis, Barcelona, Spain. [Denholm, Justin T.] Peter Doherty Inst Infect & Immun, Victorian Infect Dis Serv, Parkville, Vic, Australia. [Denholm, Justin T.] Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Parkville, Vic, Australia. [Dominguez, Samuel R.] Univ Colorado, Sch Med, Childrens Hosp Colorado, Dept Pediat Infect Dis, Aurora, CO USA. [Duarte, Pericles A. D.] Univ Estadual Oeste Parana, Cascavel, Brazil. [Dubnov-Raz, Gal] Chaim Sheba Med Ctr, Edmond & Lily Safra Childrens Hosp, Ramat Gan, Israel. [Echavarria, Marcela] CEMIC Univ Hosp, Clin Virol Lab, Buenos Aires, DF, Argentina. [Fanella, Sergio] Univ Manitoba, Sect Pediat Infect Dis, Winnipeg, MB, Canada. [Gao, Zhancheng] Peking Univ, Peoples Hosp, Dept Resp & Crit Care Med, Beijing 100871, Peoples R China. [Gerardin, Patrick] Grp Hosp Sud Reunion, Ctr Hosp Univ, Paediat Intens Care Unit, Neonatal Intens Care Unit, St Pierre, Reunion. [Gerardin, Patrick] Univ La Reunion, Ctr Hosp Univ, Natl Inst Hlth & Med Res, Ctr Clin Invest 1410, St Pierre, Reunion. [Gerardin, Patrick] Univ La Reunion, Ctr Hosp Univ, Natl Inst Hlth & Med Res,Res & Dev Inst, Cyclotron Reunion Ocean Indien,Unite Mixte Rech P, St Denis, Reunion. [Giannella, Maddalena] Hosp Gen Univ Gregorio Maranon, Dept Clin Microbiol & Infect Dis, Madrid, Spain. [Gubbels, Sophie] Statens Serum Inst, Dept Infect Dis Epidemiol, Sect Natl Hlth Documentat & Res, DK-2300 Copenhagen, Denmark. [Herberg, Jethro] Univ London Imperial Coll Sci Technol & Med, Div Infect Dis, Paediat Sect, London, England. [Higuera Iglesias, Anjarath L.] Inst Nacl Enfermedades Resp, Epidemiol Res Unit, Mexico City, DF, Mexico. [Hoger, Peter H.] Catholic Childrens Hosp Wilhelmstift, Hamburg, Germany. [Hu, Xiaoyun] Peking Union Med Coll, Beijing 100021, Peoples R China. [Islam, Quazi T.] Dhaka Med Coll Hosp, Dhaka, Bangladesh. [Jimenez, Mirela F.] Univ Fed Ciencias Saude Porto Alegre, Dept Obstet & Ginecol, Preceptora Residencia Med Hosp Femina, Porto Alegre, RS, Brazil. [Kandeel, Amr] Minist Hlth Egypt, Cairo, Egypt. [Keijzers, Gerben] Gold Coast Hosp, Gold Coast, Australia. [Khalili, Hossein] Univ Tehran Med Sci, Fac Pharm, Dept Clin Pharm, Tehran, Iran. [Knight, Marian] Univ Oxford, Nuffield Dept Populat Hlth, Natl Perinatal Epidemiol Unit, Oxford, England. [Kudo, Koichiro] Natl Ctr Global Hlth & Med, Tokyo, Japan. [Kusznierz, Gabriela] Natl Inst Resp Dis Dr Emilio Coni, Santa Fe, Argentina. [Kuzman, Ilija] Univ Zagreb, Sch Med, Univ Hosp Infect Dis, Zagreb 41001, Croatia. [Kwan, Arthur M. C.] Pamela Youde Nethersole Eastern Hosp, Dept Intens Care, Hong Kong, Hong Kong, Peoples R China. [Amine, Idriss Lahlou] Univ Mohammed V Souissi, Fac Med & Pharm, Mohammed V Mil Teaching Hosp, Biosafety Level & Res Lab 3, Rabat, Morocco. [Langenegger, Eduard] Univ Stellenbosch, Dept Obstet & Gynaecol, Cape Town, South Africa. [Langenegger, Eduard] Tygerberg Hosp, Cape Town, South Africa. [Lankarani, Kamran B.] Shiraz Univ Med Sci, Ctr Hlth Policy Res, Shiraz, Iran. [Leo, Yee-Sin] Tan Tock Seng Hosp, Dept Infect Dis, Singapore, Singapore. [Linko, Rita] Helsinki Univ Hosp, Helsinki, Finland. [Liu, Pei] China Med Univ, Affiliated Hosp 1, Dept Infect Dis, Shenyang, Peoples R China. [Madanat, Faris] King Hussein Canc Ctr, Dept Pediat, Amman, Jordan. [Mayo-Montero, Elga] Minist Def, Inst Med Prevent Def, Madrid, Spain. [McGeer, Allison] Univ Toronto, Toronto Invas Bacterial Dis Network, Toronto, ON, Canada. [Memish, Ziad] Minist Hlth, Riyadh, Saudi Arabia. [Memish, Ziad] Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia. [Metan, Gokhan] Erciyes Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Kayseri, Turkey. [Mickiene, Aukse] Lithuanian Univ Hlth Sci, Kaunas, Lithuania. [Mikic, Dragan] Mil Med Acad, Clin Infect & Trop Dis, Belgrade 11002, Serbia. [Mohn, Kristin G. I.] Haukeland Hosp, Dept Med, Infect Dis Sect, N-5021 Bergen, Norway. [Mohn, Kristin G. I.] Haukeland Hosp, Dept Res & Dev, N-5021 Bergen, Norway. [Mohn, Kristin G. I.] Univ Bergen, Dept Clin Sci, Influenza Ctr, Bergen, Norway. [Moradi, Ahmadreza] Johns Hopkins Univ, Sch Med, Dept Ophthalmol, Div Ocular Immunol, Baltimore, MD 21205 USA. [Moradi, Ahmadreza] Shahid Beheshti Univ Med Sci, Massih Daneshvari Hosp, Natl Res Inst TB & Lung Dis, Tehran, Iran. [Nymadawa, Pagbajabyn] Minist Hlth, Natl Ctr Communicable Dis, Natl Influenza Ctr, Ulaanbaatar, Mongol Peo Rep. [Oliva, Maria E.] Hosp San Martin de Parana, Dept Infect Control, Entre Rios, Argentina. [Ozkan, Mehpare] Dr Sami Ulus Res & Training Hosp Womens & Childre, Clin Pediat Neurol, Ankara, Turkey. [Parekh, Dhruv] Univ Birmingham, Sch Clin & Expt Med, Crit Care & Pain Perioperat Crit Care & Trauma Tr, Birmingham B15 2TT, W Midlands, England. [Paul, Mical] Rambam Hlth Care Campus, Div Infect Dis, Haifa, Israel. [Polack, Fernando P.] Vanderbilt Univ, Dept Pediat, Vanderbilt Vaccine Ctr, Nashville, TN USA. [Polack, Fernando P.] Fdn INFANT, Buenos Aires, DF, Argentina. [Rath, Barbara A.] Charite Univ Med Ctr, Dept Pediat, Div Pneumonol Immunol, Berlin, Germany. [Rodriguez, Alejandro H.] Univ Rovira & Virgili, Hosp Joan 23, Crit Care Dept, Inst Invest Sanitaria Pere Virgili, E-43007 Tarragona, Spain. [Sarrouf, Elena B.] Minist Salud Tucuman, San Miguel De Tucuman, Argentina. [Seale, Anna C.] Bristol Childrens Hosp, Paediat Intens Care Unit, Bristol, Avon, England. [Seale, Anna C.] Univ Bristol, Sch Clin Sci, Bristol Childrens Vaccine Ctr, Bristol, Avon, England. [Sertogullarindan, Bunyamin] Yuzuncu Yil Univ, Fac Med, Dept Pulm Med, Van, Turkey. [Siqueira, Marilda M.] Fiocruz MS, Inst Oswaldo Cruz, Lab Resp Viruses, BR-21045900 Rio De Janeiro, Brazil. [Skret-Magierlo, Joanna] Uniwersytet Rzeszowski, Rzeszow, Poland. [Stephan, Frank] Univ Basel Hosp, Dept Emergency Med, CH-4031 Basel, Switzerland. [Talarek, Ewa] Med Univ Warsaw, Dept Childrens Infect Dis, Warsaw, Poland. [Tang, Julian W.] Natl Univ Singapore Hosp, Div Microbiol, Mol Diagnost Ctr, Dept Lab Med, Singapore 117548, Singapore. [Tang, Julian W.] Univ Alberta Hosp, Alberta Prov Lab Publ Hlth, Edmonton, AB T6G 2B7, Canada. [Tang, Julian W.] Univ Alberta, Dept Med Microbiol & Immunol, Edmonton, AB, Canada. [To, Kelvin K. W.] Univ Hong Kong, Queen Mary Hosp, Carol Yu Ctr Infect, Hong Kong, Hong Kong, Peoples R China. [To, Kelvin K. W.] Univ Hong Kong, Queen Mary Hosp, Dept Microbiol, Div Infect Dis, Hong Kong, Hong Kong, Peoples R China. [Torres, Antoni] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain. [Torun, Selda H.] Istanbul Fac Med, Dept Pediat Infect Dis, Istanbul, Turkey. [Dat Tran] Univ Toronto, Hosp Sick Children, Dept Paediat, Div Infect Dis, Toronto, ON M5G 1X8, Canada. [Uyeki, Timothy M.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Van Zwol, Annelies] Vrije Univ Amsterdam Med Ctr, Dept Pediat Intens Care, Amsterdam, Netherlands. [Vaudry, Wendy] Univ Alberta, Stollery Childrens Hosp, Dept Pediat, Div Infect Dis, Edmonton, AB, Canada. [Vidmar, Tjasa] Gen Hosp Slovenj Gradec, Slovenj Gradec, Slovenia. [Yokota, Renata T. C.] Minist Saude, Secretaria Vigilancia Saude, Dept Vigilancia Epidemiol, Brasilia, DF, Brazil. [Zarogoulidis, Paul] Democritus Univ Thrace, Univ Gen Hosp Alexandroupolis, Infect Dis Unit, Dragana, Greece. RP Nguyen-Van-Tam, JS (reprint author), Univ Nottingham, City Hosp, Clin Sci Bldg, Nottingham NG5 1PB, England. EM jvt@nottingham.ac.uk RI Knight, Marian/B-6225-2009; mcgeer, allison /H-7747-2014; Dubnov-Raz, Gal/L-3297-2016; Bouza, Emilio/D-8661-2014; Giannella, Maddalena/K-9090-2016; OI Keijzers, Gerben/0000-0003-1100-4552; Loh, Tze Ping/0000-0002-4272-0001; Bagheri Lankarani, Kamran/0000-0002-7524-9017; El Rhaffouli, Hicham/0000-0003-3391-1014; Hoeger, Peter/0000-0003-3268-7479; tabarsi, payam/0000-0002-8932-5420; Viasus, Diego/0000-0001-8408-3947; Nguyen-Van-Tam, Jonathan/0000-0003-2579-4655; cilloniz, catia/0000-0002-4646-9838; Myles, Puja/0000-0002-8976-890X; Knight, Marian/0000-0002-1984-4575; mcgeer, allison /0000-0001-5647-6137; Dubnov-Raz, Gal/0000-0003-1469-8043; Bouza, Emilio/0000-0001-6967-9267; Cox, Rebecca Jane/0000-0002-8341-4078; Khandaker, Gulam/0000-0002-0661-4113; Herberg, Jethro/0000-0001-6941-6491; Denholm, Justin/0000-0002-9214-6431; Parekh, Dhruv/0000-0002-1508-8362; Giannella, Maddalena/0000-0001-8273-7601; Seale, Anna/0000-0002-0129-3146; To, Kelvin/0000-0002-1921-5824 FU F Hoffmann-La Roche FX F Hoffmann-La Roche. NR 34 TC 151 Z9 155 U1 9 U2 69 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 2213-2600 J9 LANCET RESP MED JI Lancet Resp. Med. PD MAY PY 2014 VL 2 IS 5 BP 395 EP 404 DI 10.1016/S2213-2600(14)70041-4 PG 10 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA AI2VN UT WOS:000336716300022 PM 24815805 ER PT J AU Kane, DJ Sappenfield, WM AF Kane, Debra J. Sappenfield, William M. TI Ascertainment of Medicaid Payment for Delivery on the Iowa Birth Certificate: Is Accuracy Sufficient for Timely Policy and Program Relevant Analysis? SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Medicaid; Paid claims; Birth certificate data; Validity; Reliability; Kappa statistic; Sensitivity ID RELIABILITY; VALIDITY; AGREEMENT; INSURANCE; RECORDS AB The Iowa Department of Public Health annually links Medicaid claims data to the birth certificate. Because the latest version of the birth certificate provides more timely and less costly information on delivery payment source, we were interested in assessing the validity and reliability of the birth certificate payment source compared to Medicaid paid claims. We linked Medicaid paid claims to birth certificates for calendar years 2007-2009 (n = 120,626). We measured reliability by Kappa statistic and validity by sensitivity, specificity, predictive value positive and negative. We examined reliability and validity overall and by maternal characteristics (e. g. age, race, ethnicity, education). The Kappa statistic for the birth certificate payment source indicated substantial agreement (0.78; 95 % CL 0.78-0.79). Sensitivity and specificity were also high, 86.3 % (95 % CL 86.0-86 6 %) and 91.9 % (95 % CL 91.7-92.1 %), respectively. The predictive value positive was 87.0 %. The predictive value negative was 91.4 %. Kappa and specificity were lower among women of racial and ethnic minorities, women younger than age 24, and women with less education. The overall Kappa, sensitivity and specificity generally suggest the birth certificate payment source is as valid and reliable as the linked data source. The birth certificate payment source is less valid and reliable for women of racial and ethnic minorities, women younger than age 24, and those with less education. Consequently caution should be exercised when using the birth certificate payment source for monitoring service use by the Medicaid population within specific population subgroups. C1 [Kane, Debra J.] Iowa Dept Publ Hlth, Des Moines, IA 50319 USA. [Kane, Debra J.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Sappenfield, William M.] Univ S Florida, Coll Publ Hlth, Lawton & Rhea Chiles Ctr Healthy Mothers & Babies, Div Family Hlth Serv,Dept Community & Family Hlth, Tampa, FL 33612 USA. RP Kane, DJ (reprint author), Iowa Dept Publ Hlth, Lucas State Off Bldg,321 East 12th St, Des Moines, IA 50319 USA. EM dkane@cdc.gov; wsappenf@health.usf.edu NR 25 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 EI 1573-6628 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD MAY PY 2014 VL 18 IS 4 BP 970 EP 977 DI 10.1007/s10995-013-1325-7 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AI3CA UT WOS:000336735200023 PM 23832375 ER PT J AU Fan, L Owusu-Edusei, K Schillie, SF Murphy, TV AF Fan, Lin Owusu-Edusei, Kwame, Jr. Schillie, Sarah F. Murphy, Trudy V. TI Cost-Effectiveness of Testing Hepatitis B-Positive PregnantWomen for Hepatitis B e Antigen or Viral Load SO OBSTETRICS AND GYNECOLOGY LA English DT Article; Proceedings Paper CT 2nd Conference of the INFORMS on Healthcare CY JUN 23-26, 2013 CL Chicago, IL SP INFORMS ID TO-CHILD TRANSMISSION; VIRUS INFECTION; UNITED-STATES; PERINATAL TRANSMISSION; VERTICAL TRANSMISSION; IMMUNE GLOBULIN; LATE PREGNANCY; PREVENTION; LAMIVUDINE; VACCINATION AB OBJECTIVE: To estimate the cost-effectiveness of testing pregnant women with hepatitis B (hepatitis B surface antigen [HBsAg]-positive) for hepatitis B e antigen (HBeAg) or hepatitis B virus (HBV) DNA, and administering maternal antiviral prophylaxis if indicated, to decrease breakthrough perinatal HBV transmission from the U. S. health care perspective. METHODS: A Markov decision model was constructed for a 2010 birth cohort of 4 million neonates to estimate the cost-effectiveness of two strategies: testing HBsAg-positive pregnant women for 1) HBeAg or 2) HBV load. Maternal antiviral prophylaxis is given from 28 weeks of gestation through 4 weeks postpartum when HBeAg is positive or HBV load is high (10(8) copies/mL or greater). These strategies were compared with the current recommendation. All neonates born to HBsAg-positive women received recommended active-passive immunoprophylaxis. Effects were measured in quality-adjusted life-years (QALYs) and all costs were in 2010 U. S. dollars. RESULTS: The HBeAg testing strategy saved $3.3 million and 3,080 QALYs and prevented 486 chronic HBV infections compared with the current recommendation. The HBV load testing strategy cost $3 million more than current recommendation, saved 2,080 QALYs, and prevented 324 chronic infections with an incremental cost-effectiveness ratio of $1,583 per QALY saved compared with the current recommendations. The results remained robust over a wide range of assumptions. CONCLUSION: Testing HBsAg-positive pregnant women for HBeAg or HBV load followed by maternal antiviral prophylaxis if HBeAg-positive or high viral load to reduce perinatal hepatitis B transmission in the United States is cost-effective. C1 [Fan, Lin; Owusu-Edusei, Kwame, Jr.; Schillie, Sarah F.; Murphy, Trudy V.] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. RP Fan, L (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,MS G-37, Atlanta, GA 30333 USA. EM Wqm3@cdc.gov FU Intramural CDC HHS [CC999999] NR 50 TC 10 Z9 10 U1 0 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 EI 1873-233X J9 OBSTET GYNECOL JI Obstet. Gynecol. PD MAY PY 2014 VL 123 IS 5 BP 929 EP 937 DI 10.1097/AOG.0000000000000124 PG 9 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA AI4BD UT WOS:000336809400004 PM 24785842 ER PT J AU Callaghan, WM Grobman, WA Kilpatrick, SJ Main, EK D'Alton, M AF Callaghan, William M. Grobman, William A. Kilpatrick, Sarah J. Main, Elliott K. D'Alton, Mary TI Facility-Based Identification of Women With Severe Maternal Morbidity It Is Time to Start SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID UNITED-STATES; SCORING SYSTEM; MORTALITY AB Although maternal deaths have been the traditional indicator of maternal health, these events are the "tip of the iceberg" in that there are many women who have significant complications of pregnancy, labor, and delivery. Identifying women who experience severe maternal morbidity and reviewing their care can provide critical information to inform quality improvement in obstetrics. In this commentary, we review methods to identify women who experienced severe complications of pregnancy. We propose a simple validated approach based on transfusion of four or more units of blood products, admission to an intensive care unit, or both as a starting point for identification and review of severe maternal morbidity in health care settings for the purpose of understanding successes and failures in systems of care. C1 [Callaghan, William M.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA. Northwestern Univ, Dept Obstet, Feinberg Sch Med, Chicago, IL 60611 USA. Northwestern Univ, Dept Gynecol, Feinberg Sch Med, Chicago, IL 60611 USA. Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA. Columbia Univ Coll Phys & Surg, New York, NY 10032 USA. Calif Maternal Qual Care Collaborat, Palo Alto, CA USA. RP Callaghan, WM (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, 4770 Buford Highway,MS F-74, Atlanta, GA 30341 USA. EM wgc0@cdc.gov FU Intramural CDC HHS [CC999999] NR 12 TC 30 Z9 31 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 EI 1873-233X J9 OBSTET GYNECOL JI Obstet. Gynecol. PD MAY PY 2014 VL 123 IS 5 BP 978 EP 981 DI 10.1097/AOG.0000000000000218 PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA AI4BD UT WOS:000336809400011 PM 24785849 ER PT J AU Tepper, NK Boulet, SL Whiteman, MK Monsour, M Marchbanks, PA Hooper, WC Curtis, KM AF Tepper, Naomi K. Boulet, Sheree L. Whiteman, Maura K. Monsour, Michael Marchbanks, Polly A. Hooper, W. Craig Curtis, Kathryn M. TI Postpartum Venous Thromboembolism Incidence and Risk Factors SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID POPULATION-BASED COHORT; PREGNANCY; PERIOD AB OBJECTIVE: To calculate incidence of postpartum venous thromboembolism by week after delivery and to examine potential risk factors for venous thromboembolism overall and at different times during the postpartum period. METHODS: A deidentified health care claims information database from employers, health plans, hospitals, and Medicaid programs across the United States was used to identify delivery hospitalizations among women aged 15-44 years during the years 2005-2011. International Classification of Diseases, 9th Revision, Clinical Modification diagnosis and procedure codes were used to identify instances of venous thromboembolism and associated characteristics and conditions among women with recent delivery. Incidence proportions of venous thromboembolism by week postpartum through week 12 were calculated per 10,000 deliveries. Logistic regression was used to calculate odds ratios for selected risk factors among women with postpartum venous thromboembolism and among women with venous thromboembolism during the early or later postpartum periods. RESULTS: The incidence proportion of postpartum venous thromboembolism was highest during the first 3 weeks after delivery, dropping from nine per 10,000 during the first week to one per 10,000 at 4 weeks after delivery and decreasing steadily through the 12th week. Certain obstetric procedures and complications such as cesarean delivery, preeclampsia, hemorrhage, and postpartum infection conferred an increased risk for venous thromboembolism (odds ratios ranging from 1.3 to 6.4), which persisted over the 12-week period compared with women without these risk factors. CONCLUSION: Risk for postpartum venous thromboembolism is highest during the first 3 weeks after delivery. Women with obstetric complications are at highest risk for postpartum venous thromboembolism, and this risk remains elevated throughout the first 12 weeks after delivery. C1 Ctr Dis Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, Atlanta, GA 30333 USA. Ctr Dis Control, Natl Ctr Birth Defects & Dev Disabil, Div Reprod Hlth, Atlanta, GA 30333 USA. RP Tepper, NK (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway,Mailstop F-74, Atlanta, GA 30341 USA. EM ntepper@cdc.gov NR 18 TC 15 Z9 15 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 EI 1873-233X J9 OBSTET GYNECOL JI Obstet. Gynecol. PD MAY PY 2014 VL 123 IS 5 BP 987 EP 996 DI 10.1097/AOG.0000000000000230 PG 10 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA AI4BD UT WOS:000336809400013 PM 24785851 ER PT J AU Alemnji, G Fonjungo, P Van Der Pol, B Peter, T Kantor, R Nkengasong, J AF Alemnji, George Fonjungo, Peter Van Der Pol, Barbara Peter, Trevor Kantor, Rami Nkengasong, John TI The Centrality of Laboratory Services in the HIV Treatment and Prevention Cascade: The Need for Effective Linkages and Referrals in Resource-Limited Settings SO AIDS PATIENT CARE AND STDS LA English DT Article ID EARLY ANTIRETROVIRAL THERAPY; FOLLOW-UP; CARE; HIV/AIDS; TRANSMISSION; INFECTION; PROGRAM; SYSTEMS; IMPACT; TUBERCULOSIS AB Strong laboratory services and systems are critical for delivering timely and quality health services that are vital to reduce patient attrition in the HIV treatment and prevention cascade. However, challenges exist in ensuring effective laboratory health systems strengthening and linkages. In particular, linkages and referrals between laboratory testing and other services need to be considered in the context of an integrated health system that includes prevention, treatment, and strategic information. Key components of laboratory health systems that are essential for effective linkages include an adequate workforce, appropriate point-of-care (POC) technology, available financing, supply chain management systems, and quality systems improvement, including accreditation. In this review, we highlight weaknesses of and gaps between laboratory testing and other program services. We propose a model for strengthening these systems to ensure effective linkages of laboratory services for improved access and retention in care of HIV/AIDS patients, particularly in low- and middle-income countries. C1 [Alemnji, George] Ctr Dis Control & Prevent, Caribbean Reg Off, Div Global HIV AIDS, Bridgetown Bbd, Barbados. [Fonjungo, Peter; Nkengasong, John] Ctr Dis Control & Prevent, Div Global HIV AIDS, Int Lab Branch, Atlanta, GA USA. [Van Der Pol, Barbara] Univ Alabama Birmingham, Sch Med, Div Infect Dis, Birmingham, AL USA. [Peter, Trevor] Clinton Hlth Access Initiat, Gaboren, Botswana. [Kantor, Rami] Brown Univ, Div Infect Dis, Providence, RI 02912 USA. RP Alemnji, G (reprint author), Ctr Dis Control & Prevent, Caribbean Reg Off, Div Global HIV AIDS, Bridgetown Bbd, Barbados. EM ikv3@cdc.gov OI Van Der Pol, Barbara/0000-0003-3064-8564 FU President's Emergency Plan for AIDS Relief (PEPFAR) through the Centers for Disease Control and Prevention (CDC) FX This research has been supported by the President's Emergency Plan for AIDS Relief (PEPFAR) through the Centers for Disease Control and Prevention (CDC). The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the CDC/Agency for Toxic Substances and Disease Registry. NR 37 TC 10 Z9 10 U1 0 U2 4 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1087-2914 EI 1557-7449 J9 AIDS PATIENT CARE ST JI Aids Patient Care STDS PD MAY 1 PY 2014 VL 28 IS 5 BP 268 EP 273 DI 10.1089/apc.2013.0356 PG 6 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AH0BF UT WOS:000335783300007 PM 24742299 ER PT J AU Spindler, H Salyuk, T Vitek, C Rutherford, G AF Spindler, Hilary Salyuk, Tetyana Vitek, Charles Rutherford, George TI Underreporting of HIV Transmission Among Men Who Have Sex with Men in the Ukraine SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Letter C1 [Spindler, Hilary; Rutherford, George] Univ Calif San Francisco, Global Hlth Sci, San Francisco, CA 94618 USA. [Salyuk, Tetyana] Int HIV AIDS Alliance Ukraine, Kiev, Ukraine. [Vitek, Charles] Ctr Dis Control & Prevent, Div Global HIV AIDS, Dulles, VA USA. RP Spindler, H (reprint author), Univ Calif San Francisco, Global Hlth Sci, 50 Beale St,Suite 1200, San Francisco, CA 94618 USA. EM hspindler@psg.ucsf.edu FU NIMH NIH HHS [P30 MH062246] NR 7 TC 1 Z9 1 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD MAY 1 PY 2014 VL 30 IS 5 BP 407 EP 408 DI 10.1089/aid.2013.0237 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AG8IL UT WOS:000335661900002 PM 24295084 ER PT J AU Rasmussen, SA AF Rasmussen, S. A. TI Teratology and Public Health: Working Together to Make Recommendations for Pregnant Women in the Face of Uncertainty SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Meeting Abstract C1 [Rasmussen, S. A.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD MAY PY 2014 VL 100 IS 5 SI SI BP 362 EP 362 PG 1 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA AH7AG UT WOS:000336283800009 ER PT J AU Hoyt, AT Canfield, MA Shaw, GM Waller, DK Polen, KD Ramadhani, T Anderka, M Scheuerle, AE AF Hoyt, A. T. Canfield, M. A. Shaw, G. M. Waller, D. K. Polen, K. D. Ramadhani, T. Anderka, M. Scheuerle, A. E. TI The Relationship of Sociodemographic and Hispanic Acculturation Factors with Isolated Anotia/Microtia SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Meeting Abstract C1 [Hoyt, A. T.; Canfield, M. A.] Texas Dept State Hlth Serv, Birth Defects Epidemiol & Surveillance Branch, Austin, TX USA. [Shaw, G. M.] Stanford Univ, Sch Med, Dept Pediat, Palo Alto, CA 94304 USA. [Waller, D. K.] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Houston, TX 77030 USA. [Polen, K. D.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Ramadhani, T.] Texas Educ Agcy, Div Res & Anal, Austin, TX USA. [Anderka, M.] Massachusetts Dept Publ Hlth, Boston, MA USA. [Scheuerle, A. E.] Tesserae Genet, Dallas, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD MAY PY 2014 VL 100 IS 5 SI SI BP 399 EP 399 PG 1 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA AH7AG UT WOS:000336283800075 ER PT J AU Carmichael, SL Rasmussen, SA Cunningham, ML Ma, C Browne, ML Lammer, EJ Shaw, GM AF Carmichael, S. L. Rasmussen, S. A. Cunningham, M. L. Ma, C. Browne, M. L. Lammer, E. J. Shaw, G. M. TI Craniosynostosis and Exposures Related to Thyroid Function SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Meeting Abstract C1 [Carmichael, S. L.; Ma, C.; Shaw, G. M.] Stanford Univ, Stanford, CA 94305 USA. [Rasmussen, S. A.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Lammer, E. J.] Childrens Hosp Oakland Res Inst, Oakland, CA USA. [Cunningham, M. L.] Univ Washington, Seattle, WA 98195 USA. [Browne, M. L.] New York State Dept Hlth, Albany, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD MAY PY 2014 VL 100 IS 5 SI SI BP 409 EP 409 PG 1 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA AH7AG UT WOS:000336283800095 ER PT J AU Dawson, AL Riehle-Colarusso, T Reefhuis, J Arena, JF AF Dawson, A. L. Riehle-Colarusso, T. Reefhuis, J. Arena, J. F. TI Maternal Exposure to Methotrexate and Birth Defects: A Population-Based Study SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Meeting Abstract C1 [Dawson, A. L.; Riehle-Colarusso, T.; Reefhuis, J.; Arena, J. F.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD MAY PY 2014 VL 100 IS 5 SI SI BP 423 EP 423 PG 1 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA AH7AG UT WOS:000336283800121 ER PT J AU Willis, ED Marko, A Marin, M Rasmussen, SA Bialek, SR Redfield, A Dana, A AF Willis, E. D. Marko, A. Marin, M. Rasmussen, S. A. Bialek, S. R. Redfield, A. Dana, A. TI Pregnancy Registry for Varicella-Zoster Virus-Containing Vaccines: 17-Year Summary of Pregnancy Outcomes SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Meeting Abstract C1 [Willis, E. D.; Marko, A.; Redfield, A.; Dana, A.] Merck & Co Inc, N Wales, PA USA. [Marin, M.; Rasmussen, S. A.; Bialek, S. R.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD MAY PY 2014 VL 100 IS 5 SI SI BP 437 EP 437 PG 1 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA AH7AG UT WOS:000336283800149 ER PT J AU Cox, N AF Cox, Nancy TI Influenza seasonality: timing and formulation of vaccines SO BULLETIN OF THE WORLD HEALTH ORGANIZATION LA English DT Editorial Material C1 Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA. RP Cox, N (reprint author), Ctr Dis Control & Prevent, Influenza Div, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM njc1@cdc.gov NR 8 TC 8 Z9 8 U1 0 U2 0 PU WORLD HEALTH ORGANIZATION PI GENEVA 27 PA MARKETING AND DISSEMINATION, CH-1211 GENEVA 27, SWITZERLAND SN 0042-9686 EI 1564-0604 J9 B WORLD HEALTH ORGAN JI Bull. World Health Organ. PD MAY PY 2014 VL 92 IS 5 BP 311 EP 311 DI 10.2471/BLT.14.139428 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AH9RB UT WOS:000336478400002 PM 24839317 ER PT J AU Saha, S Chadha, M Al Mamun, A Rahman, M Sturm-Ramirez, K Chittaganpitch, M Pattamadilok, S Olsen, SJ Sampurno, OD Setiawaty, V Pangesti, KNA Samaan, G Archkhawongs, S Vongphrachanh, P Phonekeo, D Corwin, A Touch, S Buchy, P Chea, N Kitsutani, P Mai, LQ Thiem, VD Lin, R Low, C Kheong, CC Ismail, N Yusof, MA Tandoc, A Roque, V Mishra, A Moen, AC Widdowson, MA Partridge, J Lal, RB AF Saha, Siddhartha Chadha, Mandeep Al Mamun, Abdullah Rahman, Mahmudur Sturm-Ramirez, Katharine Chittaganpitch, Malinee Pattamadilok, Sirima Olsen, Sonja J. Sampurno, Ondri Dwi Setiawaty, Vivi Pangesti, Krisna Nur Andriana Samaan, Gina Archkhawongs, Sibounhom Vongphrachanh, Phengta Phonekeo, Darouny Corwin, Andrew Touch, Sok Buchy, Philippe Chea, Nora Kitsutani, Paul Le Quynh Mai Vu Dinh Thiem Lin, Raymond Low, Constance Kheong, Chong Chee Ismail, Norizah Yusof, Mohd Apandi Tandoc, Amado, III Roque, Vito., Jr. Mishra, Akhilesh Moen, Ann C. Widdowson, Marc-Alain Partridge, Jeffrey Lal, Renu B. TI Influenza seasonality and vaccination timing in tropical and subtropical areas of southern and south-eastern Asia SO BULLETIN OF THE WORLD HEALTH ORGANIZATION LA English DT Article ID PANDEMIC INFLUENZA; PRODUCTION CAPACITY; VIRUSES; SURVEILLANCE; EPIDEMIOLOGY; TRANSMISSION; MORTALITY; INDONESIA; PATTERNS; VACCINES AB Objective To characterize influenza seasonality and identify the best time of the year for vaccination against influenza in tropical and subtropical countries of southern and south-eastern Asia that lie north of the equator. Methods Weekly influenza surveillance data for 2006 to 2011 Were obtained from Bangladesh, Cambodia, India, Indonesia, the Lao People's Democratic Republic, Malaysia, the Philippines, Singapore, Thailand and Viet Nam. Weekly rates of influenza activity were based on the percentage of all nasopharyngeal samples collected during the year that tested positive for influenza virus or viral nucleic acid on any given week. Monthly positivity rates were then calculated to define annual peaks of influenza activity in each country and across countries. Findings Influenza activity peaked between June/July and October in seven countries, three of which showed a second peak in December to February. Countries closer to the equator had year-round circulation without discrete peaks. Viral types and subtypes varied from year to year but not across countries in a given year. The cumulative proportion of specimens that tested positive from June to November was >60% in Bangladesh, Cambodia, India, the Lao People's Democratic Republic, the Philippines, Thailand and Viet Nam. Thus, these tropical and subtropical countries exhibited earlier influenza activity peaks than temperate climate countries north of the equator. Conclusion Most southern and south-eastern Asian countries lying north of the equator should consider vaccinating against influenza from April to June; countries near the equator without a distinct peak in influenza activity can base vaccination timing on local factors. C1 [Saha, Siddhartha] Ctr Dis Control & Prevent, Influenza Programme, US Embassy, New Delhi, India. [Chadha, Mandeep; Mishra, Akhilesh] Natl Inst Virol, Pune, Maharashtra, India. [Al Mamun, Abdullah; Sturm-Ramirez, Katharine; Lal, Renu B.] Int Ctr Diarrhoea Dis Res Bangladesh, Dhaka, Bangladesh. [Rahman, Mahmudur] Inst Epidemiol Dis Control & Res, Dhaka, Bangladesh. [Chittaganpitch, Malinee; Pattamadilok, Sirima] Minist Publ Hlth, Natl Inst Hlth, Nonthaburi, Thailand. [Olsen, Sonja J.] Ctr Dis Control & Prevent, Influenza Programme, Nonthaburi, Thailand. [Sampurno, Ondri Dwi; Setiawaty, Vivi; Pangesti, Krisna Nur Andriana] Minist Hlth, Jakarta, Indonesia. [Samaan, Gina] Ctr Dis Control & Prevent, Jakarta, Indonesia. [Archkhawongs, Sibounhom; Vongphrachanh, Phengta; Phonekeo, Darouny] Minist Hlth, Viangchan, Laos. [Corwin, Andrew] Ctr Dis Control & Prevent, Influenza Programme, Viangchan, Laos. [Touch, Sok] Minist Hlth, Phnom Penh, Cambodia. [Buchy, Philippe] Inst Pasteur, Phnom Penh, Cambodia. [Chea, Nora] WHO, Phnom Penh, Cambodia. [Kitsutani, Paul] Ctr Dis Control & Prevent, Influenza Programme, Phnom Penh, Cambodia. [Le Quynh Mai; Vu Dinh Thiem] Natl Inst Hyg & Epidemiol, Hanoi, Vietnam. [Lin, Raymond; Low, Constance] Minist Hlth, Singapore, Singapore. [Kheong, Chong Chee] Minist Hlth, Kuala Lumpur, Malaysia. [Ismail, Norizah] Natl Publ Hlth Lab, Kuala Lumpur, Malaysia. [Yusof, Mohd Apandi] Inst Med Res, Kuala Lumpur 50588, Malaysia. [Tandoc, Amado, III] Res Inst Trop Med, Alabang, Philippines. [Roque, Vito., Jr.] Dept Hlth, Manila, Philippines. [Moen, Ann C.; Widdowson, Marc-Alain] Ctr Dis Control & Prevent, Atlanta, GA USA. [Partridge, Jeffrey] Ctr Dis Control & Prevent, Influenza Programme, Hanoi, Vietnam. RP Lal, RB (reprint author), Int Ctr Diarrhoea Dis Res Bangladesh, Dhaka, Bangladesh. EM rbl3@cdc.gov FU World Health Organization [001] NR 43 TC 39 Z9 39 U1 1 U2 3 PU WORLD HEALTH ORGANIZATION PI GENEVA 27 PA MARKETING AND DISSEMINATION, CH-1211 GENEVA 27, SWITZERLAND SN 0042-9686 EI 1564-0604 J9 B WORLD HEALTH ORGAN JI Bull. World Health Organ. PD MAY PY 2014 VL 92 IS 5 BP 318 EP 330 DI 10.2471/BLT.13.124412 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AH9RB UT WOS:000336478400011 PM 24839321 ER PT J AU Bhattacharya, A AF Bhattacharya, Anasua TI Costs of occupational musculoskeletal disorders (MSDs) in the United States SO INTERNATIONAL JOURNAL OF INDUSTRIAL ERGONOMICS LA English DT Article DE Musculoskeletal disorders; Bureau of Labor Statistics; Medical costs; Indemnity costs ID CUMULATIVE TRAUMA DISORDERS; UPPER EXTREMITY; WORKERS; DISABILITY AB Background: For the years 1992-2010 musculoskeletal disorders (MSDs) accounted for 29-35% of all occupational injuries and illnesses involving days away from work in the United States (US) (AFL-CIO, 2012). According to the American Federation of Labor and Congress of Industrial Organizations (AFL-CIO) 2012 report 'Death on the Job', for the years 1992 through 2010 the percent of cases involving MSDs in private industry were highest in 2000 (35%) and lowest in 2007 (29%). In 2010, the median number of days away from work for MSDs was 11 compared to 8 for all occupational injury cases involving days away from work; the median number of days away from work for Carpal Tunnel Syndrome (CTS) was 25, more than three times as high as for all other BLS injuries involving days away from work (BLS, 2011). This study estimated the costs of work related MSDs, and given that the number of days lost due to CTS is very high, it also estimated the costs of CTS separately in the United States (US) for the years 2003 through 2007. Methods: The costs of work related MSDs and CTS in the US were estimated using the cost-of-illness, human capital method (Leigh et al., 2000), using some of the costs from the literature. This method decomposes costs into direct and indirect categories. Estimates of total cost of MSDs and CTS were obtained from the product of average costs of MSDs and CTS and the number of MSDs and CTS. The number of MSDs and CTS were obtained from BLS data. Results: The number of reported work-related MSDs declined from 435,180 in 2003 to 335,390 in 2007 and the reported number of CTS also declined from 22,110 in 2003 to 11,920 in 2007. The direct costs of MSDs and CTS were respectively $1.5 billion and $0.1 billion for the year 2007. The indirect costs were $1.1 billion and $0.1 billion for MSDs and CTS respectively for the year 2007. Discussion: This study found that the total costs of work-related MSDs and CTS declined during the period 2003 through 2007 but the average costs per case went up signifying that medical costs and other associated costs increased during this period. Relevance to industry: The costs of MSDs are important to the industries too as a significant part of these costs are borne by the employers. Industries with higher prevalence of MSDs are affected more in terms of lost productivities due to the employees' days away from work because of MSDs. In cases of MSDs causing permanent disabilities, new hiring and training costs are also a part of the losses experienced by the employers. Published by Elsevier B.V. C1 NIOSH, Ctr Dis Control & Prevent, Educ & Informat Div, Cincinnati, OH 45226 USA. RP Bhattacharya, A (reprint author), NIOSH, Ctr Dis Control & Prevent, Educ & Informat Div, MS C-15,4676 Columbia Pkwy, Cincinnati, OH 45226 USA. EM fwa4@cdc.gov NR 20 TC 10 Z9 10 U1 3 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-8141 EI 1872-8219 J9 INT J IND ERGONOM JI Int. J. Ind. Ergon. PD MAY PY 2014 VL 44 IS 3 BP 448 EP 454 DI 10.1016/j.ergon.2014.01.008 PG 7 WC Engineering, Industrial; Ergonomics SC Engineering GA AH5QV UT WOS:000336186900014 ER PT J AU Rodrigues, EG Smith, K Maule, AL Sjodin, A Li, Z Romanoff, L Kelsey, K Proctor, S McClean, MD AF Rodrigues, Ema G. Smith, Kristen Maule, Alexis L. Sjodin, Andreas Li, Zheng Romanoff, Lovisa Kelsey, Karl Proctor, Susan McClean, Michael D. TI Urinary Polycyclic Aromatic Hydrocarbon (OH-PAH) Metabolite Concentrations and the Effect of GST Polymorphisms Among US Air Force Personnel Exposed to Jet Fuel SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID GENETIC POLYMORPHISMS; INHALATION EXPOSURE; NAPHTHALENE; BIOMARKERS; 1-HYDROXYPYRENE; 2-NAPHTHOL; NAPHTHOLS; CYP1A1; CYP2E1; JP-8 AB Objective: To evaluate the association between inhalation exposure to jet propulsion fuel 8 (JP-8) and urinary metabolites among US Air Force (USAF) personnel, and investigate the role of glutathione S-transferase polymorphisms. Methods: Personal air samples were collected from 37 full-time USAF personnel during 4 consecutive workdays and analyzed for JP-8 constituents and total hydrocarbons. Pre- and postshift urine samples were collected each day and analyzed for polycyclic aromatic hydrocarbon urinary metabolites. Results: Work shift exposure to total hydrocarbons was significantly associated with postshift urinary 1-naphthol ( = 0.17; P = <0.0001), 2-naphthol ( = 0.09; P = 0.005), and 2-hydroxyfluorene concentrations ( = 0.08; P = 0.006), and a significant gene-environment interaction was observed with glutathione S-transferase mu-1. Conclusions: USAF personnel experience inhalation exposure to JP-8, which is associated with absorption of JP-8 constituents while performing typical job-related tasks, and in our data the glutathione S-transferase mu-1 polymorphism was associated with differential metabolism of naphthalene. C1 [Rodrigues, Ema G.; Smith, Kristen] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA. [Maule, Alexis L.; Proctor, Susan; McClean, Michael D.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02215 USA. [Sjodin, Andreas; Li, Zheng; Romanoff, Lovisa] Ctr Dis Control & Prevent, Organ Analyt Toxicol Branch, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA. [Kelsey, Karl] Brown Univ, Sch Med, Dept Epidemiol, Providence, RI 02912 USA. [Proctor, Susan] US Army, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. [Proctor, Susan] VA Boston Healthcare Syst, Boston, MA USA. RP Rodrigues, EG (reprint author), 665 Huntington Ave,Bldg 1 Room 1404F, Boston, MA 02115 USA. EM emarod@hsph.harvard.edu RI Sjodin, Andreas/F-2464-2010; McClean, Michael/J-2934-2015 FU US Army Medical Research and Materiel Command Award [W81XWH-06-1-0105] FX This research project was funded by the US Army Medical Research and Materiel Command Award (W81XWH-06-1-0105; PI: SP Proctor) to the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. NR 24 TC 4 Z9 4 U1 0 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 EI 1536-5948 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD MAY PY 2014 VL 56 IS 5 BP 465 EP 471 DI 10.1097/JOM.0000000000000142 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AH1FZ UT WOS:000335866500003 PM 24806557 ER PT J AU Gu, JK Charles, LE Bang, KM Ma, CC Andrew, ME Violanti, JM Burchfiel, CM AF Gu, Ja K. Charles, Luenda E. Bang, Ki Moon Ma, Claudia C. Andrew, Michael E. Violanti, John M. Burchfiel, Cecil M. TI Prevalence of Obesity by Occupation Among US Workers The National Health Interview Survey 2004-2011 SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID BODY-MASS INDEX; SELF-REPORTED WEIGHT; COMMERCIAL DRIVERS; ADULTS; HEALTH; RISK; COMPENSATION; HEIGHT; INJURY; IMPACT AB Objective: To estimate the prevalence of obesity and the change of prevalence of obesity between 2004-2007 and 2008-20011 by occupation among US workers in the National Health Interview Survey. Methods: Self-reported weight and height were collected and used to assess obesity (body mass index 30 kg/m(2)). Gender-, race/ethnicity-, and occupation-specific prevalence of obesity were calculated. Results: Prevalence of obesity steadily increased from 2004 through 2008 across gender and race/ethnicity but leveled off from 2008 through 2011. Non-Hispanic black female workers in health care support (49.2%) and transportation/material moving (46.6%) had the highest prevalence of obesity. Prevalence of obesity in relatively low-obesity (white-collar) occupations significantly increased between 2004-2007 and 2008-2011, whereas it did not change significantly in high-obesity (blue-collar) occupations. Conclusions: Workers in all occupational categories are appropriate targets for health promotion and intervention programs to reduce obesity. C1 [Gu, Ja K.; Charles, Luenda E.; Ma, Claudia C.; Andrew, Michael E.; Burchfiel, Cecil M.] Ctr Dis Control & Prevent, Biostat & Epidemiol Branch, Hlth Effects Lab Div, NIOSH, Morgantown, WV USA. [Bang, Ki Moon] Ctr Dis Control & Prevent, Surveillance Branch, Div Resp Dis Studies, NIOSH, Morgantown, WV USA. [Violanti, John M.] SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Social & Prevent Med, Buffalo, NY 14260 USA. RP Gu, JK (reprint author), NIOSH, HELD, BEB, Mailstop L-4050,1095 Willowdale Rd, Morgantown, WV 26505 USA. EM jgu@cdc.gov FU Intramural CDC HHS [CC999999] NR 36 TC 12 Z9 12 U1 1 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 EI 1536-5948 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD MAY PY 2014 VL 56 IS 5 BP 516 EP 528 DI 10.1097/JOM.0000000000000133 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AH1FZ UT WOS:000335866500011 PM 24682108 ER PT J AU Nordin, JD Kharbanda, EO Benitez, GV Lipkind, H Vellozzi, C DeStefano, F AF Nordin, James D. Kharbanda, Elyse Olshen Benitez, Gabriela Vazquez Lipkind, Heather Vellozzi, Claudia DeStefano, Frank CA Vaccine Safety Datalink TI Maternal Influenza Vaccine and Risks for Preterm or Small for Gestational Age Birth SO JOURNAL OF PEDIATRICS LA English DT Article ID CARE UTILIZATION INDEX; SAFETY DATALINK; PREGNANT-WOMEN; PERINATAL OUTCOMES; NEONATAL OUTCOMES; H1N1 INFLUENZA; UNITED-STATES; IMMUNIZATION; ADEQUACY; EPISODES AB Objective To study the impact of influenza vaccine administered to pregnant women during all trimesters on the rates of preterm and small for gestational age (SGA) births, evaluating both increased and decreased risk. Study design This retrospective observational matched cohort study involved 7 Vaccine Safety Datalink sites across the US for the 2004-05 through 2008-09 influenza seasons. Cohort eligibility and outcomes were determined from administrative, claims, medical records, and birth data. In propensity score-and vaccine exposure time-matched analyses, ORs for preterm and SGA births were calculated. Results Among 57 554 matched vaccinated and unvaccinated pregnant women, including 16 240 women in the first trimester, maternal vaccination was not associated with increased or decreased risk for preterm birth (OR for delivery at <37 weeks gestation, 0.97 [95% CI, 0.93-1.02]; for delivery at <= 32 weeks gestation, 0.98 [95% CI, 0.86-1.12]; and for delivery at <= 34 weeks gestation, 0.96 [95% CI, 0.88-1.04]) or SGA birth (OR for <5th percentile weight for gestational age, 1.02 [95% CI, 0.96-1.09], and for <10th percentile weight for gestational age, 1.00 [95% CI, 0.96-1.04]). Similarly, first trimester vaccination was not associated with increased or decreased risk for preterm or SGA birth. Conclusion Receipt of trivalent inactivated influenza vaccine during pregnancy was not associated with increased or decreased risk of preterm or SGA birth. These findings support the safety of vaccinating pregnant women against influenza during the first, second, and third trimesters, and suggest that a nonspecific protective effect of the influenza vaccine for these outcomes does not exist. C1 [Nordin, James D.; Kharbanda, Elyse Olshen; Benitez, Gabriela Vazquez] HealthPartners Inst Educ & Res, Minneapolis, MN 55440 USA. [Lipkind, Heather] Yale Univ, Dept Obstet & Gynecol, New Haven, CT USA. [Vellozzi, Claudia; DeStefano, Frank] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Nordin, JD (reprint author), HealthPartners Inst Educ & Res, Minneapolis, MN 55440 USA. FU America's Health Insurance Plans (Centers for Disease Control and Prevention) [200-2002-00732] FX Supported by a subcontract with America's Health Insurance Plans (under 200-2002-00732 from the Centers for Disease Control and Prevention). The findings and conclusions in this study are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. The authors declare no conflicts of interest. NR 40 TC 28 Z9 28 U1 0 U2 6 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD MAY PY 2014 VL 164 IS 5 BP 1051 EP + DI 10.1016/j.jpeds.2014.01.037 PG 9 WC Pediatrics SC Pediatrics GA AG6GB UT WOS:000335516000023 PM 24582484 ER PT J AU Neri, EM Ballman, MR Lu, H Greenlund, KJ Grunbaum, JA AF Neri, Elizabeth M. Ballman, Marie R. Lu, Hua Greenlund, Kurt J. Grunbaum, Jo Anne TI Academic-Health Department Collaborative Relationships Are Reciprocal and Strengthen Public Health Practice: Results from a Study of Academic Research Centers SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE public health; collaboration; core functions and essential public health services; academic health department ID UNIVERSITY PARTNERSHIP; LOCAL HEALTH; DEPARTMENTS; COMMUNITY; MODEL; PREPAREDNESS; LINKAGES AB Background: Collaborations between academic institutions and state and local health departments have been shown to enhance the public health core functions of Assurance by improving the public health workforce's knowledge and skills. Few studies have analyzed how academic-health department collaborations enhance Assessment and Policy Development core functions. This qualitative study explores types of collaborations between health departments and Prevention Research Centers (PRCs) and how they align with the core functions. Prevention Research Centers are academic institutions funded by the Centers for Disease Control and Prevention to conduct public health research and translate research results for policies and practices. Methods: We reviewed each PRC's annual report from fiscal year 2011 and abstracted descriptions of PRC-health department collaborations. We identified 14 themes of PRC-health department collaborations and conducted a qualitative analysis to describe the dimensions and distribution of themes. Results: Of the 37 PRCs, 36 reported 215 collaborations with 19 city, 97 county, 31 state, and 46 tribal health departments. Themes of research, survey, and surveillance aligned with the Assessment core function and evaluation, strategic planning, technical assistance, and program implementation supported the Policy Development and Assurance core functions. Overall, health departments provided on-the-ground expertise to inform PRC research, ensuring its applicability to public health practice. Reciprocally, PRCs improved data quality, increased the scientific rigor of health department processes and programs, and filled knowledge gaps within health departments. Both PRCs and health departments enhanced the relevance of public health programs and practices by grounding implementation and evaluation in community needs and views. Conclusion: Findings from this study demonstrate that PRC-health department collaborations often enhanced multiple core functions that could lead to implementation of evidence-based interventions and continuous quality improvement of public health administration at the local, state, and tribal levels. This study highlights the value and importance of reciprocal academic-health department partnerships. C1 [Neri, Elizabeth M.; Ballman, Marie R.; Greenlund, Kurt J.; Grunbaum, Jo Anne] Ctr Dis Control & Prevent, Prevent Res Ctr Program, Appl Res & Translat Branch, Div Populat Hlth,Natl Ctr Chron Dis Prevent & Hlt, Atlanta, GA 30341 USA. [Lu, Hua] Ctr Dis Control & Prevent, Epidemiol & Surveillance Branch, Div Populat Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Neri, EM (reprint author), Ctr Dis Control & Prevent, Prevent Res Ctr Program, Appl Res & Translat Branch, Div Populat Hlth,Natl Ctr Chron Dis Prevent & Hlt, Mailstop F-78 4770 Buford Hwy, Atlanta, GA 30341 USA. EM eneri@cdc.gov NR 26 TC 5 Z9 5 U1 1 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD MAY-JUN PY 2014 VL 20 IS 3 BP 342 EP 348 DI 10.1097/PHH.0b013e3182a152c6 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AH1FR UT WOS:000335865700016 PM 24667197 ER PT J AU Lankau, EW Turner, PV Mullan, RJ Galland, GG AF Lankau, Emily W. Turner, Patricia V. Mullan, Robert J. Galland, G. Gale TI Use of Nonhuman Primates in Research in North America SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Article DE APV; Association of Primate Veterinarians; CDC; Centers for Disease Control and Prevention; NHP; nonhuman primate ID BIOMEDICAL-RESEARCH; AIDS RESEARCH; MODELS; ANIMALS; DEBATE AB In North America, the biomedical research community faces social and economic challenges to nonhuman primate (NHP) importation that could reduce the number of NHP available for research needs. The effect of such limitations on specific biomedical research topics is unknown. The Association of Primate Veterinarians (APV), with assistance from the Centers for Disease Control and Prevention, developed a survey regarding biomedical research involving NHP in the United States and Canada. The survey sought to determine the number and species of NHP maintained at APV members' facilities, current uses of NHP to identify the types of biomedical research that rely on imported animals, and members' perceived trends in NHP research. Of the 149 members contacted, 33 (22%) replied, representing diverse facility sizes and types. Cynomolgus and rhesus macaques were the most common species housed at responding institutions and comprised the majority of newly acquired and imported NHP. The most common uses for NHP included pharmaceutical research and development and neuroscience, neurology, or neuromuscular disease research. Preclinical safety testing and cancer research projects usually involved imported NHP, whereas research on aging or degenerative disease, reproduction or reproductive disease, and organ or tissue transplantation typically used domestic-bred NHP. The current results improve our understanding of the research uses for imported NHP in North America and may facilitate estimating the potential effect of any future changes in NHP accessibility for research purposes. Ensuring that sufficient NHP are available for critical biomedical research remains a pressing concern for the biomedical research community in North America. C1 [Lankau, Emily W.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Lankau, Emily W.; Mullan, Robert J.; Galland, G. Gale] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA USA. [Lankau, Emily W.] LandCow Consulting, Athens, GA USA. [Turner, Patricia V.] Univ Guelph, Dept Pathobiol, Guelph, ON N1G 2W1, Canada. RP Lankau, EW (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM landcow.ecohealth@gmail.com RI Lankau, Emily/C-8057-2011 OI Lankau, Emily/0000-0002-7094-7780 FU CDC FX We thank APV members for their participation in this survey and the APV Board of Directors and the Division of Global Migration and Quarantine at CDC for supporting this work. Thanks also to John Farrar for assistance with survey delivery and Nicole Cohen and Adam Langer (Division of Global Migration and Quarantine, CDC) for assistance with survey development and data analysis. NR 24 TC 5 Z9 5 U1 2 U2 11 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1559-6109 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD MAY PY 2014 VL 53 IS 3 BP 278 EP 282 PG 5 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA AH5UJ UT WOS:000336196300008 PM 24827570 ER PT J AU Henderson, ZT Suchdev, DB Abe, K Johnston, EO Callaghan, WM AF Henderson, Zsakeba T. Suchdev, Danielle B. Abe, Karon Johnston, Emily Osteen Callaghan, William M. TI Perinatal Quality Collaboratives: Improving Care for Mothers and Infants SO JOURNAL OF WOMENS HEALTH LA English DT Article ID UNITED-STATES; RATES AB Perinatal morbidity and mortality are key indicators of a nation's health status. These measures of our nation's health are influenced by decisions made in health care facilities and by health care providers. As our health systems and health care for women and infants can be improved, there is an expectation that these measures of health will also improve. State-based perinatal quality collaboratives (PQCs) are networks of perinatal care providers including hospitals, clinicians, and public health professionals working to improve pregnancy outcomes for women and newborns through continuous quality improvement. Members of the collaborative are healthcare facilities, primarily hospitals, which identify processes of care that require improvement and then use the best available methods to effect change and improve outcomes as quickly as possible. The Division of Reproductive Health at the Centers for Disease Control and Prevention is collaborating with state-based PQCs to enhance their ability to improve perinatal care by expanding the range of neonatal and maternal health issues addressed and including higher proportions of participating hospitals in their state PQC. The work of PQCs is cross-cutting and demonstrates how partnerships can act to translate evidence-based science to clinical care. C1 [Henderson, Zsakeba T.; Suchdev, Danielle B.; Abe, Karon; Johnston, Emily Osteen; Callaghan, William M.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30333 USA. RP Henderson, ZT (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, 4770 Buford Highway Northeast,Mailstop F-74, Atlanta, GA 30333 USA. EM zhenderson@cdc.gov FU U.S. Federal Centers for Disease Control and Prevention FX This work was funded by the U.S. Federal Centers for Disease Control and Prevention. We thank the leadership of the California Perinatal Quality Care Collaborative, California Maternal Quality Care Collaborative, the New York State Perinatal Quality Collaborative, and the Ohio Perinatal Quality Collaborative for their input and lessons learned during this project. NR 17 TC 6 Z9 6 U1 0 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 EI 1931-843X J9 J WOMENS HEALTH JI J. Womens Health PD MAY 1 PY 2014 VL 23 IS 5 BP 368 EP 372 DI 10.1089/jwh.2014.4744 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA AG9KY UT WOS:000335739300002 PM 24655150 ER PT J AU Hammer, GP Auvinen, A De Stavola, BL Grajewski, B Gundestrup, M Haldorsen, T Hammar, N Lagorio, S Linnersjo, A Pinkerton, L Pukkala, E Rafnsson, V dos-Santos-Silva, I Storm, HH Strand, TE Tzonou, A Zeeb, H Blettner, M AF Hammer, Gael P. Auvinen, Anssi De Stavola, Bianca L. Grajewski, Barbara Gundestrup, Maryanne Haldorsen, Tor Hammar, Niklas Lagorio, Susanna Linnersjo, Anette Pinkerton, Lynne Pukkala, Eero Rafnsson, Vilhjalmur dos-Santos-Silva, Isabel Storm, Hans H. Strand, Trond-Eirik Tzonou, Anastasia Zeeb, Hajo Blettner, Maria TI Mortality from cancer and other causes in commercial airline crews: a joint analysis of cohorts from 10 countries SO OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID COSMIC-RADIATION EXPOSURE; FEMALE FLIGHT ATTENDANTS; CABIN ATTENDANTS; COCKPIT CREW; PILOTS; RISK; AIRCRAFT; HEALTH; DISRUPTION; EXPERIENCE AB Background Commercial airline crew is one of the occupational groups with the highest exposures to ionising radiation. Crew members are also exposed to other physical risk factors and subject to potential disruption of circadian rhythms. Methods This study analyses mortality in a pooled cohort of 93771 crew members from 10 countries. The cohort was followed for a mean of 21.7years (2.0 million person-years), during which 5508 deaths occurred. Results The overall mortality was strongly reduced in male cockpit (SMR 0.56) and female cabin crews (SMR 0.73). The mortality from radiation-related cancers was also reduced in male cockpit crew (SMR 0.73), but not in female or male cabin crews (SMR 1.01 and 1.00, respectively). The mortality from female breast cancer (SMR 1.06), leukaemia and brain cancer was similar to that of the general population. The mortality from malignant melanoma was elevated, and significantly so in male cockpit crew (SMR 1.57). The mortality from cardiovascular diseases was strongly reduced (SMR 0.46). On the other hand, the mortality from aircraft accidents was exceedingly high (SMR 33.9), as was that from AIDS in male cabin crew (SMR 14.0). Conclusions This large study with highly complete follow-up shows a reduced overall mortality in male cockpit and female cabin crews, an increased mortality of aircraft accidents and an increased mortality in malignant skin melanoma in cockpit crew. Further analysis after longer follow-up is recommended. C1 [Hammer, Gael P.; Blettner, Maria] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Med Biostat Epidemiol & Informat, D-55122 Mainz, Germany. [Hammer, Gael P.] Lab Natl Sante, Registre Morphol Tumeurs, Luxembourg, Luxembourg. [Auvinen, Anssi; Pukkala, Eero] Univ Tampere, Sch Hlth Sci, FIN-33101 Tampere, Finland. [Pukkala, Eero] Finnish Canc Registry, Inst Stat & Epidemiol Canc Res, FIN-00170 Helsinki, Finland. [Auvinen, Anssi] STUK Radiat & Nucl Safety Author, Helsinki, Finland. [De Stavola, Bianca L.; dos-Santos-Silva, Isabel] Univ London London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, England. [De Stavola, Bianca L.; dos-Santos-Silva, Isabel] Univ London London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, Dept Med Stat, London WC1E 7HT, England. [Grajewski, Barbara; Pinkerton, Lynne] NIOSH, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Gundestrup, Maryanne] Univ Copenhagen Hosp, Clin Aviat Med, DK-2100 Copenhagen, Denmark. [Haldorsen, Tor] Canc Registry Norway, Inst Populat Based Canc Res, Oslo, Norway. [Hammar, Niklas] Karolinska Inst, Inst Environm Med, Unit Epidemiol, Stockholm, Sweden. [Lagorio, Susanna] Natl Inst Hlth, Natl Ctr Epidemiol Surveillance & Hlth Promot, Rome, Italy. [Linnersjo, Anette] Karolinska Inst, Inst Environm Med, Unit Cardiovasc Epidemiol, Stockholm, Sweden. [Linnersjo, Anette] Stockholm Cty Council, Ctr Occupat & Environm Med, Stockholm, Sweden. [Rafnsson, Vilhjalmur] Univ Iceland, Reykjavik, Iceland. [Storm, Hans H.] Danish Canc Soc, Copenhagen, Denmark. [Strand, Trond-Eirik] Norwegian Armed Forces Med Serv, Inst Aviat Med, Oslo, Norway. [Tzonou, Anastasia] Univ Athens, Athens, Greece. [Zeeb, Hajo] Leibniz Inst Prevent Res & Epidemiol BIPS GmbH, Bremen, Germany. RP Auvinen, A (reprint author), Lab Natl Sante EP, Registre Morphol Tumeurs, L-3555 Dudelange, Luxembourg. EM gael.hammer@lns.etat.lu OI Strand, Trond-Eirik/0000-0002-7561-3501; Storm, Hans/0000-0001-7223-8198; Auvinen, Anssi/0000-0003-1125-4818; dos Santos Silva, Isabel/0000-0002-6596-8798 FU German Federal Office for Radiation Protection [StSch 4558] FX This work was supported by the German Federal Office for Radiation Protection (grant number StSch 4558) for study coordination. NR 66 TC 13 Z9 14 U1 3 U2 17 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1351-0711 EI 1470-7926 J9 OCCUP ENVIRON MED JI Occup. Environ. Med. PD MAY PY 2014 VL 71 IS 5 BP 313 EP 322 DI 10.1136/oemed-2013-101395 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AF0IM UT WOS:000334397500004 PM 24389960 ER PT J AU Marcewicz, L Clayton, J Maenner, M Grant, A Odom, E Okoroh, E Goodman, A Christensen, D Traylor, J Miller, A Warren, M AF Marcewicz, Lauren Clayton, Joshua Maenner, Matthew Grant, Althea Odom, Erika Okoroh, Ekwutosi Goodman, Alyson Christensen, Deborah Traylor, Julie Miller, Angela Warren, Michael TI LATE VITAMIN K DEFICIENCY BLEEDING IN INFANTS NOT RECEIVING PROPHYLAXIS SO PEDIATRIC BLOOD & CANCER LA English DT Meeting Abstract C1 [Marcewicz, Lauren; Clayton, Joshua; Maenner, Matthew; Grant, Althea; Odom, Erika; Okoroh, Ekwutosi; Goodman, Alyson; Christensen, Deborah; Traylor, Julie; Miller, Angela; Warren, Michael] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1545-5009 EI 1545-5017 J9 PEDIATR BLOOD CANCER JI Pediatr. Blood Cancer PD MAY PY 2014 VL 61 SU 1 SI SI BP S45 EP S45 PG 1 WC Oncology; Hematology; Pediatrics SC Oncology; Hematology; Pediatrics GA AG5WT UT WOS:000335490100157 ER PT J AU Tai, E Thompson, T Thomas, C Fairley, T Richardson, L AF Tai, Eric Thompson, Trevor Thomas, Cheryll Fairley, Temeika Richardson, Lisa TI CANCER DEATHS AVERTED AMONG CHILDREN, OLDER ADOLESCENTS, AND YOUNG ADULTS, 1975-2010 SO PEDIATRIC BLOOD & CANCER LA English DT Meeting Abstract C1 [Tai, Eric; Thompson, Trevor; Thomas, Cheryll; Fairley, Temeika; Richardson, Lisa] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1545-5009 EI 1545-5017 J9 PEDIATR BLOOD CANCER JI Pediatr. Blood Cancer PD MAY PY 2014 VL 61 SU 1 SI SI BP S88 EP S89 PG 2 WC Oncology; Hematology; Pediatrics SC Oncology; Hematology; Pediatrics GA AG5WT UT WOS:000335490100309 ER PT J AU Duffy, J Harris, J Gade, L Sehulster, L Newhouse, E O'Connell, H Noble-Wang, J Rao, C Balajee, SA Chiller, T AF Duffy, Jonathan Harris, Julie Gade, Lalitha Sehulster, Lynne Newhouse, Emily O'Connell, Heather Noble-Wang, Judith Rao, Carol Balajee, S. Arunmozhi Chiller, Tom TI Mucormycosis Outbreak Associated With Hospital Linens SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE mycoses; mucormycosis; cross infection; bedding and linens ID FUNGAL-INFECTIONS; MOLD INFECTIONS; CARE-UNITS; RHIZOPUS; EPIDEMIOLOGY; ZYGOMYCOSIS; DISEASE; LAUNDRY; IMPACT; TISSUE AB Background: Mucormycosis is an invasive fungal infection with a high fatality rate. We investigated an outbreak of mucormycosis in a pediatric hospital to determine routes of pathogen transmission from the environment and prevent additional infections. Methods: A case was defined as a hospital-onset illness consistent with mucormycosis, confirmed by culture or histopathology. Case-patient medical records were reviewed for clinical course and exposure to items and locations within the hospital. Environmental samples were collected from air and surfaces. Fungal isolates collected from case-patients and the environmental samples were identified using DNA sequencing. Results: Five case-patients had hospital-associated cutaneous mucormycosis over an 11-month period; all subsequently died. Three case-patients had conditions known to be associated with susceptibility to mucormycosis, while 2 had cardiac conditions with persistent acidosis. The cases occurred on several different wards throughout the hospital, and hospital linens were the only exposure identified as common to the case-patients. Rhizopus species were recovered from 26 (42%) of 62 environmental samples from clean linens and associated areas and from 1 (4%) of 25 samples from nonlinen-related items. Case-patients were infected with Rhizopus delemar, which was also isolated from cultures of clean linens and clean linen delivery bins from the off-site laundry facility. Conclusions: Hospital linens were identified as a vehicle that carried R. delemar into contact with susceptible patients. Fungal species identification using DNA-based methods is useful for corroborating epidemiologic links in hospital outbreak investigations. Hospital linens should be laundered, packaged, shipped and stored in a manner that minimizes exposure to environmental contaminants. C1 [Duffy, Jonathan] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Duffy, Jonathan; Sehulster, Lynne; O'Connell, Heather; Noble-Wang, Judith; Rao, Carol] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. [Harris, Julie; Gade, Lalitha; Balajee, S. Arunmozhi; Chiller, Tom] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA 30333 USA. [Newhouse, Emily] Ctr Dis Control & Prevent, Epidemiol Elect Program, Atlanta, GA 30333 USA. RP Duffy, J (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, 1600 Clifton Rd NE,MS D-26, Atlanta, GA 30333 USA. EM jduffy@cdc.gov NR 34 TC 13 Z9 14 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0891-3668 EI 1532-0987 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD MAY PY 2014 VL 33 IS 5 BP 472 EP 476 DI 10.1097/INF.0000000000000261 PG 5 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA AG9PC UT WOS:000335750600012 PM 24667485 ER PT J AU Breuner, CC Miller, RJ Braverman, PK Adelman, WP Breuner, CC Levine, DA Marcell, AV Murray, PJ O'Brien, RF Gavin, LE Pinzon, JL Shain, B Smith, KS Baumberger, J AF Breuner, Cora C. Miller, Rachel J. Braverman, Paula K. Adelman, William P. Breuner, Cora C. Levine, David A. Marcell, Arik V. Murray, Pamela J. O'Brien, Rebecca F. Gavin, Loretta E. Pinzon, Jorge L. Shain, Benjamin Smith, Karen S. Baumberger, James CA Comm Adolescence TI Addendum-Adolescent Pregnancy: Current Trends and Issues SO PEDIATRICS LA English DT Article DE adolescent health; medicine; teen pregnancy ID RISK BEHAVIOR SURVEILLANCE; UNITED-STATES; UNINTENDED PREGNANCY C1 [Gavin, Loretta E.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Miller, Rachel J.] Amer Coll Obstetricians & Gynecologists, Washington, DC USA. [Shain, Benjamin] Amer Acad Child & Adolescent Psychiat, Washington, DC USA. NR 16 TC 3 Z9 3 U1 1 U2 7 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD MAY PY 2014 VL 133 IS 5 BP 954 EP 957 DI 10.1542/peds.2014-0450 PG 4 WC Pediatrics SC Pediatrics GA AG2HK UT WOS:000335236800028 ER PT J AU Stephens, SC Fann, CK Strona, FV Wolf, W Cohen, SE Philip, SS Bernstein, KT AF Stephens, Sally C. Fann, Charles K. Strona, Frank V. Wolf, Wendy Cohen, Stephanie E. Philip, Susan S. Bernstein, Kyle T. TI Identifying Syphilis Risk Networks Through Venue Attendance in San Francisco SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID ELIMINATION; SPACE; HIV; MEN; SEX; GAY AB Background Prioritizing interventions for patients with syphilis who are part of large or interconnected sexual networks may be high yield for partner services, and identifying venues named by patients with syphilis who report high numbers of partners may help identify such networks. In this analysis, we explore differences between interviewed patients with early syphilis regarding where they met sex partners. Methods With a cross-sectional design, we examined the distribution of total reported sex partners from male index patients with early syphilis interviewed through the San Francisco Department of Public Health partner services program and the self-reported venues named as places they met sex partners. Based on the median number of total partners among male cases of syphilis who named each venue, we categorized venues into 3 levels of partner frequency: high (>15 partners reported), medium (6-15 partners reported), and low (<6 partners reported). Interviewed patients with early syphilis were then classified into these venue categories, and sociodemographic and risk behaviors from electronic medical records and interviews were compared using (2) tests. Results In 2011, 433 male patients with early syphilis named 32 venues. One hundred forty-three (32.3%) patients were categorized as high, 226 (51.0%) as medium, and 74 (16.7%) as low partner frequency venue users. Patients with early syphilis who reported meeting partners at high partner frequency venues were generally older, more likely to be white, have a previous syphilis infection, use methamphetamines in the previous year, and be HIV infected (all P < 0.05) compared with those who reported meeting partners at medium-frequency and low-frequency venues. Conclusions Venues where partners are met may be an appropriate proxy for network membership. Targeting additional resources, outreach, and services to clients who attend high-frequency venues may have a positive impact on syphilis prevention efforts. C1 [Stephens, Sally C.; Fann, Charles K.; Strona, Frank V.; Wolf, Wendy; Cohen, Stephanie E.; Philip, Susan S.; Bernstein, Kyle T.] San Francisco Dept Publ Hlth, STD Prevent & Control Serv Sect, San Francisco, CA 94103 USA. [Strona, Frank V.; Wolf, Wendy] Ctr Dis Control & Prevent, Atlanta, GA USA. [Bernstein, Kyle T.] Univ Calif Berkeley, Berkeley Sch Publ Hlth, Div Epidemiol, Berkeley, CA 94720 USA. RP Stephens, SC (reprint author), San Francisco Dept Publ Hlth, 1360 Mission St,Suite 401, San Francisco, CA 94103 USA. EM Sally.Stephens@sfdph.org FU Comprehensive STD Prevention Projects Centers for Disease Control and Prevention [1H25PS001354-01] FX This work was funded in part by the Comprehensive STD Prevention Projects (1H25PS001354-01) Centers for Disease Control and Prevention. NR 25 TC 1 Z9 1 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD MAY PY 2014 VL 41 IS 5 BP 333 EP 337 DI 10.1097/OLQ.0000000000000116 PG 5 WC Infectious Diseases SC Infectious Diseases GA AF6AR UT WOS:000334797300012 PM 24722390 ER PT J AU Kuhn, JH Bao, YM Bavari, S Becker, S Bradfute, S Brauburger, K Brister, JR Bukreyev, AA Cai, YY Chandran, K Davey, RA Dolnik, O Dye, JM Enterlein, S Gonzalez, JP Formenty, P Freiberg, AN Hensley, LE Hoenen, T Honko, AN Ignatyev, GM Jahrling, PB Johnson, KM Klenk, HD Kobinger, G Lackemeyer, MG Leroy, EM Lever, MS Muhlberger, E Netesov, SV Olinger, GG Palacios, G Patterson, JL Paweska, JT Pitt, L Radoshitzky, SR Ryabchikova, EI Saphire, EO Shestopalov, AM Smither, SJ Sullivan, NJ Swanepoel, R Takada, A Towner, JS van der Groen, G Volchkov, VE Volchkova, VA Wahl-Jensen, V Warren, TK Warfield, KL Weidmann, M Nichol, ST AF Kuhn, Jens H. Bao, Yiming Bavari, Sina Becker, Stephan Bradfute, Steven Brauburger, Kristina Brister, J. Rodney Bukreyev, Alexander A. Cai, Yingyun Chandran, Kartik Davey, Robert A. Dolnik, Olga Dye, John M. Enterlein, Sven Gonzalez, Jean-Paul Formenty, Pierre Freiberg, Alexander N. Hensley, Lisa E. Hoenen, Thomas Honko, Anna N. Ignatyev, Georgy M. Jahrling, Peter B. Johnson, Karl M. Klenk, Hans-Dieter Kobinger, Gary Lackemeyer, Matthew G. Leroy, Eric M. Lever, Mark S. Muehlberger, Elke Netesov, Sergey V. Olinger, Gene G. Palacios, Gustavo Patterson, Jean L. Paweska, Janusz T. Pitt, Louise Radoshitzky, Sheli R. Ryabchikova, Elena I. Saphire, Erica Ollmann Shestopalov, Aleksandr M. Smither, Sophie J. Sullivan, Nancy J. Swanepoel, Robert Takada, Ayato Towner, Jonathan S. van der Groen, Guido Volchkov, Viktor E. Volchkova, Valentina A. Wahl-Jensen, Victoria Warren, Travis K. Warfield, Kelly L. Weidmann, Manfred Nichol, Stuart T. TI Virus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNA SO ARCHIVES OF VIROLOGY LA English DT Article ID RECOMBINANT MARBURG VIRUS; EBOLA-VIRUS; FAMILY FILOVIRIDAE; CELL-CULTURE; GUINEA-PIGS; IRF-3 ACTIVATION; IN-VITRO; REPLICATION; TRANSCRIPTION; DOMAINS AB Specific alterations (mutations, deletions, insertions) of virus genomes are crucial for the functional characterization of their regulatory elements and their expression products, as well as a prerequisite for the creation of attenuated viruses that could serve as vaccine candidates. Virus genome tailoring can be performed either by using traditionally cloned genomes as starting materials, followed by site-directed mutagenesis, or by de novo synthesis of modified virus genomes or parts thereof. A systematic nomenclature for such recombinant viruses is necessary to set them apart from wild-type and laboratory-adapted viruses, and to improve communication and collaborations among researchers who may want to use recombinant viruses or create novel viruses based on them. A large group of filovirus experts has recently proposed nomenclatures for natural and laboratory animal-adapted filoviruses that aim to simplify the retrieval of sequence data from electronic databases. Here, this work is extended to include nomenclature for filoviruses obtained in the laboratory via reverse genetics systems. The previously developed template for natural filovirus genetic variant naming, < virus name > (< strain >/)< isolation host-suffix >/< country of sampling >/< year of sampling >/< genetic variant designation >-< isolate designation >, is retained, but we propose to adapt the type of information added to each field for cDNA clone-derived filoviruses. For instance, the full-length designation of an Ebola virus Kikwit variant rescued from a plasmid developed at the US Centers for Disease Control and Prevention could be akin to "Ebola virus H.sapiens-rec/COD/1995/Kikwit-abc1" (with the suffix "rec" identifying the recombinant nature of the virus and "abc1" being a placeholder for any meaningful isolate designator). Such a full-length designation should be used in databases and the methods section of publications. Shortened designations (such as "EBOV H.sap/COD/95/Kik-abc1") and abbreviations (such as "EBOV/Kik-abc1") could be used in the remainder of the text, depending on how critical it is to convey information contained in the full-length name. "EBOV" would suffice if only one EBOV strain/variant/isolate is addressed. C1 [Kuhn, Jens H.; Cai, Yingyun; Hensley, Lisa E.; Jahrling, Peter B.; Lackemeyer, Matthew G.; Wahl-Jensen, Victoria] NIAID, Integrated Res Facil Ft Detrick IRF Frederick, DCR, NIH, Frederick, MD 21702 USA. [Bao, Yiming; Brister, J. Rodney] NIH, Informat Engn Branch, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20892 USA. [Bavari, Sina; Dye, John M.; Honko, Anna N.; Olinger, Gene G.; Palacios, Gustavo; Pitt, Louise; Radoshitzky, Sheli R.; Warren, Travis K.] United States Army Med Res Inst Infect Dis, Frederick, MD USA. [Becker, Stephan; Dolnik, Olga; Klenk, Hans-Dieter] Univ Marburg, Inst Virol, D-35032 Marburg, Germany. [Bradfute, Steven] Univ New Mexico, Albuquerque, NM 87131 USA. [Brauburger, Kristina; Muehlberger, Elke] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA. [Brauburger, Kristina; Muehlberger, Elke] Boston Univ, Sch Med, Natl Emerging Infect Dis Lab, Boston, MA 02118 USA. [Bukreyev, Alexander A.; Freiberg, Alexander N.] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA. [Bukreyev, Alexander A.; Freiberg, Alexander N.] Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX 77555 USA. [Chandran, Kartik] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA. [Davey, Robert A.; Patterson, Jean L.] Texas Biomed Res Inst, Dept Virol & Immunol, San Antonio, TX USA. [Enterlein, Sven; Warfield, Kelly L.] Integrated BioTherapeut Inc, Gaithersburg, MD USA. [Gonzalez, Jean-Paul] Inst Rech Dev, Dept Hlth, Marseille, France. [Gonzalez, Jean-Paul] Metabiota Inc, San Francisco, CA USA. [Formenty, Pierre] World Hlth Org, Geneva, Switzerland. [Hoenen, Thomas] NIAID, Virol Lab, Div Intramural Res, NIH, Hamilton, MT USA. [Ignatyev, Georgy M.] Minist Hlth Russian Federat, Fed State Unitary Co Microgen Sci Ind Co Immunobi, Moscow, Russia. [Kobinger, Gary] Publ Hlth Agcy Canada, Natl Microbiol Lab, Special Pathogens Program, Winnipeg, MB, Canada. [Leroy, Eric M.] Ctr Int Rech Med Franceville, Franceville, Gabon. [Lever, Mark S.; Smither, Sophie J.] Dstl, Dept Biomed Sci, Salisbury, Wilts, England. [Netesov, Sergey V.; Shestopalov, Aleksandr M.] Novosibirsk State Univ, Novosibirsk 630090, Novosibirsk Reg, Russia. [Paweska, Janusz T.] Natl Inst Communicable Dis, Ctr Emerging & Zoonot Dis, Natl Hlth Lab Serv, Sandringham Johannesburg, Gauteng, South Africa. [Ryabchikova, Elena I.] Russian Acad Sci, Siberian Branch, Inst Chem Biol & Fundamental Med, Novosibirsk, Novosibirsk Reg, Russia. [Saphire, Erica Ollmann] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA. [Saphire, Erica Ollmann] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA. [Shestopalov, Aleksandr M.] State Res Ctr Virol & Biotechnol Vector, Koltsov, Novosibirsk Reg, Russia. [Sullivan, Nancy J.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Swanepoel, Robert] Univ Pretoria, Zoonoses Res Unit, ZA-0002 Pretoria, South Africa. [Takada, Ayato] Hokkaido Univ, Res Ctr Zoonosis Control, Div Global Epidemiol, Sapporo, Hokkaido, Japan. [Towner, Jonathan S.; Nichol, Stuart T.] Ctr Dis Control & Prevent CDC, Natl Ctr Emerging & Zoonot Infect Dis NCEZID, Div High Consequence Pathogens Pathol DHCPP, Viral Special Pathogens Branch VSPB, Atlanta, GA 30333 USA. [van der Groen, Guido] Prins Leopold Inst Trop Geneeskunde, Antwerp, Belgium. [Volchkov, Viktor E.; Volchkova, Valentina A.] Univ Lyon, Lab Filovirus, INSERM, U758,UCB Lyon 1,Ecole Normale Super Lyon, Lyon, France. [Weidmann, Manfred] Univ Med Gottingen, Abt Virol, Gottingen, Germany. RP Kuhn, JH (reprint author), NIAID, Integrated Res Facil Ft Detrick IRF Frederick, DCR, NIH, B-8200 Res Plaza, Frederick, MD 21702 USA. EM kuhnjens@mail.nih.gov; stn1@cdc.gov RI Volchkov, Viktor/M-7846-2014; Kuhn, Jens H./B-7615-2011; Ryabchikova, Elena /G-3089-2013; Netesov, Sergey/A-3751-2013; Becker, Stephan/A-1065-2010; Palacios, Gustavo/I-7773-2015; Weidmann, Manfred/G-1817-2015; LEROY, Eric/I-4347-2016; OI Volchkov, Viktor/0000-0001-7896-8706; Kuhn, Jens H./0000-0002-7800-6045; Ryabchikova, Elena /0000-0003-4714-1524; Netesov, Sergey/0000-0002-7786-2464; Becker, Stephan/0000-0002-2794-5659; Palacios, Gustavo/0000-0001-5062-1938; Weidmann, Manfred/0000-0002-7063-7491; Shestopalov, Alexander/0000-0002-9734-0620; LEROY, Eric/0000-0003-0022-0890; Hoenen, Thomas/0000-0002-5829-6305; Honko, Anna/0000-0001-9165-148X FU Joint Science and Technology Office for Chem Bio Defense [TMTI0048_09_RD_T]; NIAID [HHSN272200700016I]; Intramural Research Program of the NIH, National Library of Medicine; Intramural Research Program of the NIH, NIAID FX The content of this publication does not necessarily reflect the views or policies of the US Department of the Army, the US Department of Defense or the US Department of Health and Human Services or of the institutions and companies affiliated with the authors. This work was funded in part by the Joint Science and Technology Office for Chem Bio Defense (proposal #TMTI0048_09_RD_T to SB). YC, JHK, and VWJ performed this work as employees of Tunnell Consulting, Inc., and MGL as an employee of Lovelace Respiratory Research Institute, both subcontractors to Battelle Memorial Institute under its prime contract with NIAID, under Contract No. HHSN272200700016I. This research was also supported in part by the Intramural Research Program of the NIH, National Library of Medicine (YB and JRB), and the Intramural Research Program of the NIH, NIAID (TH). NR 35 TC 26 Z9 28 U1 0 U2 21 PU SPRINGER WIEN PI WIEN PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA SN 0304-8608 EI 1432-8798 J9 ARCH VIROL JI Arch. Virol. PD MAY PY 2014 VL 159 IS 5 BP 1229 EP 1237 DI 10.1007/s00705-013-1877-2 PG 9 WC Virology SC Virology GA AG9ZB UT WOS:000335777600048 PM 24190508 ER PT J AU Seo, SC Choung, JT Chen, BT Lindsley, WG Kim, KY AF Seo, SungChul Choung, Ji Tae Chen, Bean T. Lindsley, William G. Kim, Ki Youn TI The level of submicron fungal fragments in homes with asthmatic children SO ENVIRONMENTAL RESEARCH LA English DT Article DE Bioaerosols; Fine particles; Fungal fragments; Childhood asthmatics; Mold exposure ID RELATIVE MOLDINESS INDEX; AIR-POLLUTION; ULTRAFINE PARTICLES; RESPIRATORY HEALTH; URBAN AIR; MOLD; EXPOSURE; AEROSOLIZATION; MICROORGANISMS; ASSOCIATIONS AB Objectives: Much scientific evidence indicates a positive association between moldy environments and respiratory illnesses and/or symptoms (e.g., asthma). Recently, submicron fungal fragments (< 1.0 mu m) have been suggested as a potential contributor to adverse health effects due to their biological composition (e.g., antigens, mycotoxins, and (1,3)-beta-D-glucan) as well as their small size. However, the contribution of exposure to fine fungal particles on adverse health outcomes has been poorly characterized, particularly in homes with asthmatic children. We characterized the airborne level of smaller-sized fungal particles between homes with and without asthmatic children. Methods: We visited 29 homes with (n=15) and without (n=14) an asthmatic child and sampled submicron fungal fragments in a living room and child's bedroom, along with outdoor sampling, using the NIOSH two-stage sampler. (1,3)-beta-D-glucan of fungal fragments analyzed by Limulus Amebocyte lysate assay (LAL) was used for quantifying their exposure. Results: Overall, the geometric mean (GM) concentration of (1,3)-beta-D-glucan in submicron fungal fragments in indoor air was two-fold higher in homes with asthmatic children (50.9 pg/m(3)) compared to homes with non-asthmatic children (26.7 pg/m(3)) (P < 0.001). The GM concentration of these particles in child's bedroom in homes with an asthmatic child (66.1 pg/m(3)) was about three times higher than that in homes with non-asthmatic children (23.0 pg/m(3)) (P < 0.001). The relative humidity had a negative correlation with the concentration of (1,3)-beta-D-glucan in submicron fungal fragments (Pearson coefficient=-0.257, P=0.046). Conclusions: Our findings indicate that homes with asthmatic children have a higher concentration of submicron fungal fragments compared to homes with non-asthmatic children. A greater exposure to smaller-sized fungal particles may occur in homes with an asthmatic child as relative humidity decreases. The very careful control of relative humidity in indoor air is necessary for reducing exposure to fine fungal particles and inhibiting the growth of microorganisms in homes with allergic diseases. (C) 2014 Elsevier Inc. All rights reserved. C1 [Seo, SungChul; Choung, Ji Tae] Korea Univ, Environm Hlth Ctr Asthma, Seoul, South Korea. [Choung, Ji Tae] Korea Univ, Coll Med, Dept Pediat, Seoul 136705, South Korea. [Chen, Bean T.; Lindsley, William G.] NIOSH, Ctr Dis Control & Prevent, Morgantown, WV USA. [Kim, Ki Youn] Catholic Univ Pusan, Dept Ind Hlth, Pusan, South Korea. RP Kim, KY (reprint author), Catholic Univ Pusan, Dept Ind Hlth, Pusan, South Korea. EM kky5@cup.ac.kr OI Lindsley, William/0000-0003-0720-5829 FU Ministry of Environment, Republic of Korea (MOE) FX This research was supported by the Ministry of Environment, Republic of Korea (MOE) as "the Environmental Health Action Program." This support is greatly appreciated. We are also grateful to all of those who were involved in data collection at homes. NR 45 TC 11 Z9 11 U1 0 U2 14 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0013-9351 EI 1096-0953 J9 ENVIRON RES JI Environ. Res. PD MAY PY 2014 VL 131 BP 71 EP 76 DI 10.1016/j.envres.2014.02.015 PG 6 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AH3HU UT WOS:000336015100011 PM 24657943 ER PT J AU Jung, KH Liu, B Lovinsky-Desir, S Yan, BZ Camann, D Sjodin, A Li, Z Perera, F Kinney, P Chillrud, S Miller, RL AF Jung, Kyung Hwa Liu, Bian Lovinsky-Desir, Stephanie Yan, Beizhan Camann, David Sjodin, Andreas Li, Zheng Perera, Frederica Kinney, Patrick Chillrud, Steven Miller, Rachel L. TI Time trends of polycyclic aromatic hydrocarbon exposure in New York city from 2001 to 2012: Assessed by repeat air and urine samples SO ENVIRONMENTAL RESEARCH LA English DT Article DE Temporal variations; Polycyclic aromatic hydrocarbons; Urinary metabolites; Repeat exposure; Trafficemission; Heating oil combustion ID FINE PARTICULATE MATTER; BLACK CARBON; RESIDENTIAL INDOOR; METABOLITE LEVELS; BIRTH COHORT; CHILDREN; VARIABILITY; PREGNANCY; POLLUTION; ASTHMA AB Background: Exposure to air pollutants including polycyclic aromatic hydrocarbons (PAH), and specifically pyrene from combustion of fuel oil, coal, traffic and indoor sources, has been associated with adverse respiratory health outcomes. However, time trends of airborne PAR and metabolite levels detected via repeat measures over time have not yet been characterized. We hypothesized that PAH levels, measured repeatedly from residential indoor and outdoor monitors, and children's urinary concentrations of PAR metabolites, would decrease following policy interventions to reduce traffic-related air pollution. Methods: Indoor PAH (particle- and gas-phase) were collected for two weeks prenatally (n=98), at age 5/6 years (n=397) and age 9/10 years (n=198) since 2001 and at all three age-points (n=27). Other traffic-related air pollutants (black carbon and PM2.5) were monitored indoors simultaneous with PAH monitoring at ages 5/6 (n=403) and 9/10 (n=257) between 2005 and 2012. One third of the homes were selected across seasons for outdoor PAR, BC and PM2.5 sampling. Using the same sampling method, ambient PAR, BC and PM2.5 also were monitored every two weeks at a central site between 2007 and 2012. PAR were analyzed as semivolatile PAM (e.g., pyrene; MW 178-206) (Sigma(8)PAH(semivolatile): Including pyrene (PYR), phenanthrene (PHEN), 1-methylphenanthrene (1-MEPH), 2-methylphenanthrene (2-MEPH), 3-methylphenanthrene (3-MEPH), 9-methylphenanthrene (9-MEPH), 1,7-dimethylphenanthrene (1,7-DMEPH), and 3,6-dimethyl-phenanthrene (3,6-DMEPH)) and the sum of eight nonvolatile PAR (Sigma 8PAH(rionvoiatlie): Including benzo[a]-anthracene (BaA), chrysene/iso-chrysene (Chry), benzo[b]fluoranthene (BbFA), benzo[k]fluoranthene (BkFA), benzo[alpyrene (BaP), indeno[1,2,3-c,d] pyrene (IP), dibenzo[a,h] anthracene (DahA), and benzo[g,h,i]perylene (BghiP); MW 228-278). A spot urine sample was collected from children at child ages 3, 5, 7 and 9 between 2001 and 2012 and analyzed for 10 PAM metabolites. Results: Modest declines were detected in indoor BC and PM25 levels between 2005 and 2012 (Annual percent change [APC] = -2.08% [p=0.010] and -2.18% [p=0.059] for BC and PM25, respectively), while a trend of increasing pyrene levels was observed in indoor and outdoor samples, and at the central site during the comparable time periods (APC=4.81%, 3.77% and 7.90%, respectively; p < 0.05 for all). No significant time trend was observed in indoor Sigma 8PAH(nonvolatile) levels between 2005 and 2012; however, significant opposite trends were detected when analyzed seasonally (APC= 8.06% [p < 0.01], 3.87% [p < 0.05] for nonheating and heating season, respectively). Similarly, heating season also affected the annual trends (2005-2012) of other air pollutants: the decreasing BC trend (in indoor/outdoor air) was observed only in the nonheating season, consistent with dominating traffic sources that decreased with time; the increasing pyrene trend was more apparent in the heating season. Outdoor PM2.5 levels persistently decreased over time across the seasons. With the analyses of data collected over a longer period of time (2001-2012), a decreasing trend was observed in pyrene (APC= 2.76%; p < 0.01), mostly driven by measures from the nonheating season (APC= 3.54%; p < 0.01). In contrast levels of pyrene and naphthalene metabolites, 1-hydroxypyrene and 2-naphthol, increased from 2001 to 2012 (APC= 6.29% and 7.90% for 1-hydroxypyrene and 2-naphthol, respectively; p < 0.01 for both). Conclusions: Multiple NYC legislative regulations targeting traffic-related air pollution may have led to decreases in Sigma(8)PAH(nonvolatne) and BC, especially in the nonheating season. Despite the overall decrease in pyrene over the 2001-2012 periods, a rise in pyrene levels in recent years (2005-2012), that was particularly evident for measures collected during the heating season, and 2-naphthol, indicates the contribution of heating oil combustion and other indoor sources to airborne pyrene and urinary 2-naphthol. (C) 2014 Elsevier Inc. All rights reserved. C1 [Jung, Kyung Hwa; Liu, Bian; Miller, Rachel L.] Columbia Univ, Coll Phys & Surg, Dept Med, Div Pulm Allergy & Crit Care Med, New York, NY 10032 USA. [Lovinsky-Desir, Stephanie] Columbia Univ, Coll Phys & Surg, Dept Pediat, Div Pediat Pulm, New York, NY 10032 USA. [Yan, Beizhan; Chillrud, Steven] Columbia Univ, Lamont Doherty Earth Observ, Palisades, NY 10964 USA. [Camann, David] Southwest Res Inst, Chem & Chem Engn Div, San Antonio, TX 78228 USA. [Sjodin, Andreas; Li, Zheng] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Environm Hlth Lab Sci, Organ Analyt Toxicol Branch, Atlanta, GA USA. [Perera, Frederica; Kinney, Patrick; Miller, Rachel L.] Columbia Univ, Columbia Ctr Childrens Environm Hlth, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, New York, NY 10032 USA. [Miller, Rachel L.] Columbia Univ, Coll Phys & Surg, Dept Pediat, Div Pediat Allergy & Immunol, New York, NY 10032 USA. RP Miller, RL (reprint author), Columbia Univ, Coll Phys & Surg, Dept Med, Div Pulm Allergy & Crit Care Med, PH8E-101,630W 168 St, New York, NY 10032 USA. EM rlm14@cumc.columbia.edu RI Sjodin, Andreas/F-2464-2010; OI Lovinsky-Desir, Stephanie/0000-0003-2272-4387 FU NIH [R01 ES013163, P50ES015905, P01ES09600, R01ES08977, P30ES09089]; EPA [R827027, RD832096, RD832141, RD834509]; Educational Foundation of America; New York Community Trust; Trustees of the Blanchette Hooker Rockefeller Fund; John & Wendy Neu Family Foundation FX This work was supported by NIH (R01 ES013163, P50ES015905, P01ES09600, R01ES08977, P30ES09089), EPA (R827027, RD832096, RD832141, RD834509), the Educational Foundation of America, the John & Wendy Neu Family Foundation, the New York Community Trust, and the Trustees of the Blanchette Hooker Rockefeller Fund. NR 33 TC 11 Z9 11 U1 4 U2 44 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0013-9351 EI 1096-0953 J9 ENVIRON RES JI Environ. Res. PD MAY PY 2014 VL 131 BP 95 EP 103 DI 10.1016/j.envres.2014.02.017 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AH3HU UT WOS:000336015100014 PM 24709094 ER PT J AU Spector, JT De Roos, AJ Ulrich, CM Sheppard, L Sjodin, A Wener, MH Wood, B McTiernan, A AF Spector, June T. De Roos, Anneclaire J. Ulrich, Cornelia M. Sheppard, Lianne Sjoedin, Andreas Wener, Mark H. Wood, Brent McTiernan, Anne TI Plasma polychlorinated biphenyl concentrations and immune function in postmenopausal women SO ENVIRONMENTAL RESEARCH LA English DT Article DE Cytotoxicity; Immune function; Lymphocyte proliferation; Persistent organic pollutants; Polychlorinated biphenyls ID NON-HODGKIN-LYMPHOMA; KILLER-CELL CYTOTOXICITY; IN-VITRO; ENVIRONMENTAL CONTAMINANTS; ORGANOCHLORINE LEVELS; PERIPHERAL-BLOOD; CONTROLLED-TRIAL; ADIPOSE-TISSUE; HUMAN HEALTH; SEAL PUPS AB Background: Polychlorinated biphenyl (PCB) exposure has been associated with non-Hodgkin lymphoma in several studies, and the immune system is a potential mediator. Objectives: We analyzed associations of plasma PCBs with immune function measures. We hypothesized that higher plasma PCB concentrations are associated with lower immune function cross-sectionally, and that increases in PCB concentrations over a one year period are associated with decreases in immune function. Methods: Plasma PCB concentrations and immune function [natural killer (NK) cell cytotoxicity and PHA-induced T-lymphocyte proliferation (PHA-TLP)] were measured at baseline and one year in 109 postmenopausal overweight women participating in an exercise intervention study in the Seattle, Washington (USA) area. Mixed models, with adjustment for body mass index and other potential confounders, were used to estimate associations of PCBs with immune function cross-sectionally and longitudinally. Results: Associations of PCBs with immune function measures differed across groups of PCBs (e.g., medium- and high-chlorinated and dioxin-like [mono-ortho-substituted]) and by the time frame for the comparison (cross-sectional vs. longitudinal). Higher concentrations of medium- and high-chlorinated PCBs were associated with higher PHA-TLP cross-sectionally but not longitudinally. The mean decrease in 0.5 mu g/mL PHA-TLP/50.0 pmol/g-lipid increase in dioxin-like PCBs over one year was 51.6 (95% confidence interval 2.7, 100.5; P=0.039). There was no association between plasma PCBs and NK cytotoxicity. Conclusions: These results do not provide strong evidence of impaired cellular immunity from PCB exposure. Larger longitudinal studies with greater variability in PCB exposures are needed to further examine temporal associations of PCBs with immune function. (C) 2014 Elsevier Inc. All rights reserved. C1 [Spector, June T.; Sheppard, Lianne] Univ Washington, Dept Environm & Occupat Hlth Sci, Sch Publ Hlth, Seattle, WA 98105 USA. [Spector, June T.; Wener, Mark H.; Wood, Brent; McTiernan, Anne] Univ Washington, Sch Med, Dept Med, Seattle, WA 98105 USA. [De Roos, Anneclaire J.] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Epidemiol, Seattle, WA 98109 USA. [De Roos, Anneclaire J.; Ulrich, Cornelia M.; McTiernan, Anne] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98105 USA. [Ulrich, Cornelia M.] Fred Hutchinson Canc Res Ctr, Canc Prevent Program, Seattle, WA 98109 USA. [Ulrich, Cornelia M.] Natl Ctr Tumor Dis, Heidelberg, Germany. [Ulrich, Cornelia M.] German Canc Res Ctr, Heidelberg, Germany. [Sheppard, Lianne] Univ Washington, Sch Publ Hlth, Dept Biostat, Seattle, WA 98105 USA. [Sjoedin, Andreas] CDC, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. RP Spector, JT (reprint author), Univ Washington, Dept Environm & Occupat Hlth Sci & Med, 4225 Roosevelt Way NE,Suite 100, Seattle, WA 98105 USA. EM spectj@uw.edu; ajd335@drexel.edu; neli.ulrich@nct-heidelberg.de; sheppard@uw.edu; asjodin@cdc.gov; wener@u.washington.edu; woodbi@u.washington.edu; amctiem@fficrc.org RI Sjodin, Andreas/F-2464-2010 FU National Institutes of Health National Institute of Environmental Health Sciences (NIEHS) [R03 ES015787]; National Cancer Institute [R01CA/AG9334]; NIEHS [T32 ES015459] FX this research was funded by grants from the National Institutes of Health National Institute of Environmental Health Sciences (NIEHS) (R03 ES015787) and the National Cancer Institute (R01CA/AG9334). Support for JTS was provided by NIEHS (T32 ES015459). NR 55 TC 1 Z9 1 U1 0 U2 9 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0013-9351 EI 1096-0953 J9 ENVIRON RES JI Environ. Res. PD MAY PY 2014 VL 131 BP 174 EP 180 DI 10.1016/j.envres.2014.03.011 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AH3HU UT WOS:000336015100024 PM 24721136 ER PT J AU Guy, GP Berkowitz, Z Tai, E Holman, DM Jones, SE Richardson, LC AF Guy, Gery P., Jr. Berkowitz, Zahava Tai, Eric Holman, Dawn M. Jones, Sherry Everett Richardson, Lisa C. TI Indoor Tanning Among High School Students in the United States, 2009 and 2011 SO JAMA DERMATOLOGY LA English DT Article ID NONMELANOMA SKIN-CANCER; RISK BEHAVIOR SURVEILLANCE; ULTRAVIOLET-RADIATION; CUTANEOUS MELANOMA; ADOLESCENTS; HEALTH; US; INTERVENTION; METAANALYSIS; ASSOCIATION AB IMPORTANCE Indoor tanning is associated with an increased risk of skin cancer, including melanoma, and is particularly dangerous for younger and more frequent indoor tanners. OBJECTIVE To examine the prevalence of indoor tanning and frequent indoor tanning (> 10 times during the 12 months before each survey) and their association with health-related behaviors. DESIGN, SETTING, AND PARTICIPANTS A cross-sectional study examined data from the 2009 and 2011 national Youth Risk Behavior Surveys, which used nationally representative samples of US high school students representing approximately 15.5 million students each survey year. The study included 25 861 students who answered the indoor tanning question. MAIN OUTCOMES AND MEASURES The prevalence of indoor tanning and frequent indoor tanning were examined as well as their association with demographic characteristics and health-related behaviors using multivariable logistic regression modeling. RESULTS The prevalence of indoor tanning was greater among female, older, and non-Hispanic white students. Indoor tanning was highest among female students aged 18 years or older, with 31.5% engaging in indoor tanning in 2011, and among non-Hispanic white female students, with 29.3% engaging in indoor tanning in 2011. Among female students, the adjusted prevalence of indoor tanning decreased from 26.4% in 2009 to 20.7% in 2011. Among female and male students, indoor tanning was associated with other risk-taking behaviors, such as binge drinking (P <.001 and P =.006, respectively), unhealthy weight control practices (P <.001, for both), and having sexual intercourse (P <.001, for both). Additionally, indoor tanning among female students was associated with using illegal drugs (P <.001) and having sexual intercourse with 4 or more persons (P =.03); use among male students was associated with taking steroids without a physician's prescription (P <.001), smoking cigarettes daily (P =.03), and attempting suicide (P =.006). More than half of respondents engaging in indoor tanning reported frequent use of the devices. CONCLUSIONS AND RELEVANCE Indoor tanning is common among high school students. Public health efforts are needed to change social norms regarding tanned skin and to increase awareness, knowledge, and behaviors related to indoor tanning. The clustering of risky behaviors suggests a need for coordinated, multifaceted approaches, including primary care physician counseling, to address such behaviors among adolescents. C1 [Guy, Gery P., Jr.; Berkowitz, Zahava; Tai, Eric; Holman, Dawn M.; Richardson, Lisa C.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Jones, Sherry Everett] Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30341 USA. RP Guy, GP (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy NE,Mail Stop F-76, Atlanta, GA 30341 USA. EM irm2@cdc.gov FU Intramural CDC HHS [CC999999] NR 51 TC 20 Z9 20 U1 0 U2 15 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6068 EI 2168-6084 J9 JAMA DERMATOL JI JAMA Dermatol. PD MAY PY 2014 VL 150 IS 5 BP 501 EP 511 DI 10.1001/jamadermatol.2013.7124 PG 11 WC Dermatology SC Dermatology GA AH2NH UT WOS:000335957700006 PM 24577222 ER PT J AU Merte, JL Kroll, CM Collins, AS Melnick, AL AF Merte, Jennifer L. Kroll, Catherine M. Collins, Amy S. Melnick, Alan L. TI An epidemiologic investigation of occupational transmission of Mycobacterium tuberculosis infection to dental health care personnel SO JOURNAL OF THE AMERICAN DENTAL ASSOCIATION LA English DT Article DE Mycobacterium tuberculosis; infection prevention and control; contact investigation; dental office; occupational infection; delayed diagnosis ID FOR-DISEASE-CONTROL; UNITED-STATES; PREVENTION; GUIDELINES; SETTINGS; WORKERS AB Background. The authors describe an investigation of a dental hygienist who developed active pulmonary tuberculosis (TB), worked for several months while infectious and likely transmitted Mycobacterium tuberculosis in a dental setting in Washington state. Methods. Clark County Public Health (CCPH) conducted an epidemiologic investigation of 20 potentially exposed close contacts and 734 direct-care dental patients in 2010. Results. Of 20 close contacts, one family member and two coworkers, all of whom were from countries in which TB is endemic, had latent TB infection (LTBI). One U.S.-born coworker experienced a tuberculin skin test (TST) conversion from 0 to 8 millimeters. Of the 305 of 731 (41.7 percent) potentially exposed patients who received a single TST, 23 (7.5 percent) had a positive TST result of at least 5 mm. Among the subset of 157 patients tested by CCPH staff, 16 (10.2 percent) had a positive TST result. The dental office did not have infection prevention and control policies related to TB identification, prevention or education. Conclusions. The coworker's TST conversion indicated a recent infection, likely owed to occupational transmission. The proportion of dental patients with positive TST results was greater than the 1999-2000 National Health and Nutrition Examination Survey prevalence estimate in the general population, and it may reflect transmission from the hygienist with active TB or a prevalence of LTBI in the community. C1 [Merte, Jennifer L.] Ctr Dis Control & Prevent, Vancouver, WA USA. [Merte, Jennifer L.; Melnick, Alan L.] Clark Cty Publ Hlth, Vancouver, WA 98666 USA. [Kroll, Catherine M.] Clark Cty Publ Hlth, Communicable Dis Program, Vancouver, WA 98666 USA. [Collins, Amy S.] Ctr Dis Control & Prevent, Div Oral Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Melnick, Alan L.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. RP Melnick, AL (reprint author), Clark Cty Publ Hlth, 1601 E Fourth Plain Blvd,POB 9825, Vancouver, WA 98666 USA. EM Alan.Melnick@clark.wa.gov FU appointment of Jennifer Merte to the Applied Epidemiology Fellowship Program; U.S. Centers for Disease Control and Prevention [5U38HM000414-5] FX This study was supported in part by the appointment of Jennifer Merte to the Applied Epidemiology Fellowship Program administered by the Council of State and Territorial Epidemiologists and funded by the U.S. Centers for Disease Control and Prevention Cooperative Agreement 5U38HM000414-5. NR 15 TC 4 Z9 4 U1 1 U2 14 PU AMER DENTAL ASSOC PI CHICAGO PA 211 E CHICAGO AVE, CHICAGO, IL 60611 USA SN 0002-8177 EI 1943-4723 J9 J AM DENT ASSOC JI J. Am. Dent. Assoc. PD MAY PY 2014 VL 145 IS 5 BP 464 EP 471 PG 8 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA AH1YG UT WOS:000335917200014 PM 24789240 ER PT J AU Iliaki, E Chen, LH Hamer, DH Macleod, WB Jentes, ES Barnett, ED Wilson, ME AF Iliaki, Eirini Chen, Lin H. Hamer, Davidson H. Macleod, William B. Jentes, Emily S. Barnett, Elizabeth D. Wilson, Mary E. CA Boston Area Travel Med Network TI Travel to Brazil: Analysis of Data From the Boston Area Travel Medicine Network (BATMN) and Relevance to Travelers Attending World Cup and Olympics SO JOURNAL OF TRAVEL MEDICINE LA English DT Article ID UNITED-STATES; INFECTION; REGIONS; HEALTH; DENGUE; FEVER; RISK C1 [Iliaki, Eirini] Cambridge Hlth Alliance, Cambridge, England. [Chen, Lin H.] Mt Auburn Hosp, Cambridge, MA 02138 USA. [Chen, Lin H.] Harvard Univ, Sch Med, Boston, MA USA. [Hamer, Davidson H.; Macleod, William B.] Boston Univ, Ctr Global Hlth & Dev, Boston, MA 02215 USA. [Hamer, Davidson H.; Macleod, William B.] Boston Univ, Sch Publ Hlth, Dept Int Hlth, Boston, MA USA. [Hamer, Davidson H.] Boston Univ, Sch Med, Infect Dis Sect, Boston, MA 02118 USA. [Jentes, Emily S.] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA USA. [Barnett, Elizabeth D.] Boston Med Ctr, Maxwell Finland Lab Infect Dis, Boston, MA USA. [Wilson, Mary E.] Harvard Univ, Sch Publ Hlth, Dept Global Hlth & Populat, Boston, MA 02115 USA. RP Chen, LH (reprint author), Mt Auburn Hosp, 330 Mt Auburn St, Cambridge, MA 02138 USA. EM lchen@hms.harvard.edu FU CDC [1 U19CI000508-01]; Boston Medical Center [1 U19CI000508-01] FX In addition to the authors, members of the Boston Area Travel Medicine Network who contributed data include A. W. Karchmer, MD, Beth Israel Deaconess Medical Center and Harvard Medical School, L. Kogelman, MD, Tufts Medical Center, and W. W. Ooi, MD, Lahey Clinic Medical Center. The authors also thank E. Gleva, C. Benoit, R. Dufur, D. Gannon, and M. Bhussar for their assistance with data collection and entry, and M. Pfaff for data analysis. This research was funded by a cooperative agreement (1 U19CI000508-01) between CDC and Boston Medical Center. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of CDC. NR 16 TC 2 Z9 2 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1195-1982 EI 1708-8305 J9 J TRAVEL MED JI J. Travel Med. PD MAY PY 2014 VL 21 IS 3 BP 214 EP 217 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA AF0ZZ UT WOS:000334445200012 PM 24673916 ER PT J AU Torres, C Lema, C Dohmen, FG Beltran, F Novaro, L Russo, S Freire, MC Velasco-Villa, A Mbayed, VA Cisterna, DM AF Torres, C. Lema, C. Gury Dohmen, F. Beltran, F. Novaro, L. Russo, S. Freire, M. C. Velasco-Villa, A. Mbayed, V. A. Cisterna, D. M. TI Phylodynamics of vampire bat-transmitted rabies in Argentina SO MOLECULAR ECOLOGY LA English DT Article DE Argentina; phylodynamics; phylogeography; rabies virus; vampire bats ID STATISTICAL PHYLOGENETICS; GENETIC-CHARACTERIZATION; LATIN-AMERICA; VIRUS; DYNAMICS; BRAZIL; UNCERTAINTY; SEQUENCES; HISTORY; SKYLINE AB Common vampire bat populations distributed from Mexico to Argentina are important rabies reservoir hosts in Latin America. The aim of this work was to analyse the population structure of the rabies virus (RABV) variants associated with vampire bats in the Americas and to study their phylodynamic pattern within Argentina. The phylogenetic analysis based on all available vampire bat-related N gene sequences showed both a geographical and a temporal structure. The two largest groups of RABV variants from Argentina were isolated from northwestern Argentina and from the central western zone of northeastern Argentina, corresponding to livestock areas with different climatic, topographic and biogeographical conditions, which determined their dissemination and evolutionary patterns. In addition, multiple introductions of the infection into Argentina, possibly from Brazil, were detected. The phylodynamic analysis suggests that RABV transmission dynamics is characterized by initial epizootic waves followed by local enzootic cycles with variable persistence. Anthropogenic interventions in the ecosystem should be assessed taking into account not only the environmental impact but also the potential risk of disease spreading through dissemination of current RABV lineages or the emergence of novel ones associated with vampire bats. C1 [Torres, C.; Mbayed, V. A.] Univ Buenos Aires, Fac Farm & Bioquim, Catedra Virol, RA-1113 Buenos Aires, DF, Argentina. [Torres, C.; Mbayed, V. A.] Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina. [Lema, C.; Freire, M. C.; Cisterna, D. M.] Adm Nacl Labs & Inst Salud ANLIS Dr Carlos G Malb, Inst Nacl Enfermedades Infecciosas, Serv Neurovirosis, Buenos Aires, DF, Argentina. [Gury Dohmen, F.; Beltran, F.] Inst Zoonosis Dr Luis Pasteur, Buenos Aires, DF, Argentina. [Novaro, L.; Russo, S.] DILAB, SENASA, Buenos Aires, DF, Argentina. [Velasco-Villa, A.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Cisterna, DM (reprint author), Adm Nacl Labs & Inst Salud ANLIS Dr Carlos G Malb, Inst Nacl Enfermedades Infecciosas, Serv Neurovirosis, Av Velez Sarsfield 563,C1282AFF, Buenos Aires, DF, Argentina. EM dcisterna@anlis.gov.ar OI Torres, Carolina/0000-0001-6786-8769 FU INEI-ANLIS; Centers for Disease Control and Prevention, Atlanta GA, USA; American Fellows Program, Partners of the Americas of the USA Government' FX This study was supported by INEI-ANLIS 'Dr. Carlos G. Malbran, the Centers for Disease Control and Prevention, Atlanta GA, USA; and the American Fellows Program, Partners of the Americas of the USA Government'. NR 46 TC 3 Z9 3 U1 2 U2 26 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0962-1083 EI 1365-294X J9 MOL ECOL JI Mol. Ecol. PD MAY PY 2014 VL 23 IS 9 BP 2340 EP 2352 DI 10.1111/mec.12728 PG 13 WC Biochemistry & Molecular Biology; Ecology; Evolutionary Biology SC Biochemistry & Molecular Biology; Environmental Sciences & Ecology; Evolutionary Biology GA AF7PX UT WOS:000334908100018 PM 24661865 ER EF