FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Mechtler, TP Stary, S Metz, TF De Jesus, VR Greber-Platzer, S Pollak, A Herkner, KR Streubel, B Kasper, DC AF Mechtler, Thomas P. Stary, Susanne Metz, Thomas F. De Jesus, Victor R. Greber-Platzer, Susanne Pollak, Arnold Herkner, Kurt R. Streubel, Berthold Kasper, David C. TI Neonatal screening for lysosomal storage disorders: feasibility and incidence from a nationwide study in Austria SO LANCET LA English DT Article ID TANDEM MASS-SPECTROMETRY; DRIED BLOOD SPOTS; FABRY-DISEASE; INBORN-ERRORS; KRABBE-DISEASE; POMPE-DISEASE; METABOLISM; DIAGNOSIS; THERAPY; ASSAY AB Background The interest in neonatal screening for lysosomal storage disorders has increased substantially because of newly developed enzyme replacement therapies, the need for early diagnosis, and technical advances. We tested for Gaucher's disease, Pompe's disease, Fabry's disease, and Niemann-Pick disease types A and B in an anonymous prospective nationwide screening study that included genetic mutation analysis to assess the practicality and appropriateness of including these disorders in neonatal screening panels. Methods Specimens from dried blood spots of 34 736 newborn babies were collected consecutively from January, 2010 to July, 2010, as part of the national routine Austrian newborn screening programme. Anonymised samples were analysed for enzyme activities of acid beta-glucocerebrosidase, alpha-galactosidase, alpha-glucosidase, and acid sphingomyelinase by electrospray ionisation tandem mass spectrometry. Genetic mutation analyses were done in samples with suspected enzyme deficiency. Findings All 34 736 samples were analysed successfully by the multiplex screening assay. Low enzyme activities were detected in 38 babies. Mutation analysis confirmed lysosomal storage disorders in 15 of them. The most frequent mutations were found for Fabry's disease (1 per 3859 births), followed by Pompe's disease (1 per 8684), and Gaucher's disease (1 per 17 368). The positive predictive values were 32% (95% CI 16-52), 80% (28-99), and 50% (7-93), respectively. Mutational analysis detected predominantly missense mutations associated with a late-onset phenotype. Interpretation The combined overall proportion of infants carrying a mutation for lysosomal storage disorders was higher than expected. Neonatal screening for lysosomal storage disorders is likely to raise challenges for primary health-care providers. Furthermore, the high frequency of late-onset mutations makes lysosomal storage disorders a broad health problem beyond childhood. C1 [Mechtler, Thomas P.; Metz, Thomas F.; Greber-Platzer, Susanne; Pollak, Arnold; Herkner, Kurt R.; Kasper, David C.] Med Univ Vienna, Dept Pediat & Adolescent Med, A-1090 Vienna, Austria. [Stary, Susanne; Streubel, Berthold] Med Univ Vienna, Dept Pathol, A-1090 Vienna, Austria. [De Jesus, Victor R.] Ctr Dis Control & Prevent, Newborn Screening & Mol Biol Branch, Atlanta, GA USA. RP Streubel, B (reprint author), Med Univ Vienna, Dept Obstet & Gynecol, A-1090 Vienna, Austria. EM berthold.streubel@meduniwien.ac.at RI Kasper, David/B-9054-2012 FU Austrian Ministry of Health, Family, and Women; Austrian Ministry of Health, Family, and Women [GZ 20.501/40-3 IV/A/2007] FX This work was supported by grants from the Austrian Ministry of Health, Family, and Women (GZ 20.501/40-3 IV/A/2007). The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 44 TC 87 Z9 92 U1 1 U2 14 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0140-6736 J9 LANCET JI Lancet PD JAN 28 PY 2012 VL 379 IS 9813 BP 335 EP 341 DI 10.1016/S0140-6736(11)61266-X PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 889BA UT WOS:000300047300040 PM 22133539 ER PT J AU Sriram, K Lin, GX Jefferson, AM Roberts, JR Andrews, RN Kashon, ML Antonini, JM AF Sriram, Krishnan Lin, Gary X. Jefferson, Amy M. Roberts, Jenny R. Andrews, Ronnee N. Kashon, Michael L. Antonini, James M. TI Manganese accumulation in nail clippings as a biomarker of welding fume exposure and neurotoxicity SO TOXICOLOGY LA English DT Article DE Biomarker; Biomonitoring; Brain; Manganese; Nail; Neurotoxicity; Occupational exposures; Parkinson's disease; Parkinsonism; Welder; Welding fume; Workplace monitoring ID LONG-TERM EXPOSURE; SIGNAL INTENSITIES; PULMONARY-FUNCTION; MILD-STEEL; HUMAN-HAIR; RESPIRATORY SYMPTOMS; FERROALLOY WORKERS; STAINLESS-STEEL; NERVOUS-SYSTEM; ARSENIC LEVELS AB Occupational exposure to welding fumes (WF) is thought to cause Parkinson's disease (PD)-like neurological dysfunction. An apprehension that WF may accelerate the onset of PD also exists. Identifying reliable biomarkers of exposure and neurotoxicity are therefore critical for biomonitoring and neurological risk characterization of WF exposure. Manganese (Mn) in welding consumables is considered the causative factor for the neurological deficits seen in welders. Hence, we sought to determine if Mn accumulation in blood or nail clippings can be a marker for adverse exposure and neurotoxicity. To model this, rats were exposed by intratracheal instillation to dissolved or suspended fume components collected from gas metal arc-mild steel (GMA-MS) or manual metal arc-hard surfacing (MMA-HS) welding. Trace element analysis revealed selective Mn accumulation in dopaminergic brain areas, striatum (STR) and midbrain (MB), following exposure to the two fumes. This caused dopaminergic abnormality as evidenced by loss of striatal tyrosine hydroxylase (Th; 25-32% decrease) and Parkinson disease (autosomal recessive, early onset) 7 (Park7; 25-46% decrease) proteins. While blood Mn was not detectable, Mn levels in nails strongly correlated with the pattern of Mn accumulation in the striatum (R-2 = 0.9386) and midbrain (R-2 = 0.9332). Exposure to manganese chloride (MnCl2) caused similar Mn accumulation in SIR, MB and nail. Our findings suggest that nail Mn has the potential to be a sensitive and reliable biomarker for long-term Mn exposure and associated neurotoxicity. The non-invasive means by which nail clippings can be collected, stored, and transported with relative ease, make it an attractive surrogate for biomonitoring WF exposures in occupational settings. Published by Elsevier Ireland Ltd. C1 [Sriram, Krishnan; Lin, Gary X.; Jefferson, Amy M.; Roberts, Jenny R.; Kashon, Michael L.; Antonini, James M.] NIOSH, Hlth Effects Lab Div, Morgantown, WV 26505 USA. [Andrews, Ronnee N.] NIOSH, Div Appl Res & Technol, Cincinnati, OH 45213 USA. RP Sriram, K (reprint author), NIOSH, Hlth Effects Lab Div, 1095 Willowdale Rd, Morgantown, WV 26505 USA. EM kos4@cdc.gov NR 89 TC 14 Z9 18 U1 1 U2 23 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD JAN 27 PY 2012 VL 291 IS 1-3 BP 73 EP 82 DI 10.1016/j.tox.2011.10.021 PG 10 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 898OX UT WOS:000300752800010 PM 22085607 ER PT J AU Fouchier, RAM Garcia-Sastre, A Kawaoka, Y Barclay, WS Bouvier, NM Brown, IH Capua, I Chen, H Compans, RW Couch, RB Cox, NJ Doherty, PC Donis, RO Feldmann, H Guan, Y Katz, J Klenk, HD Kobinger, G Liu, JH Liu, XF Lowen, A Metten-Leiter, TC Osterhaus, ADME Palese, P Peiris, JSM Perez, DR Richt, JA Schultz-Cherry, S Steel, J Subbarao, K Swayne, DE Takimoto, T Tashiro, M Taubenberger, JK Thomas, PG Tripp, RA Tumpey, TM Webby, RJ Webster, RG AF Fouchier, Ron A. M. Garcia-Sastre, Adolfo Kawaoka, Yoshihiro Barclay, Wendy S. Bouvier, Nicole M. Brown, Ian H. Capua, Ilaria Chen, Hualan Compans, Richard W. Couch, Robert B. Cox, Nancy J. Doherty, Peter C. Donis, Ruben O. Feldmann, Heinz Guan, Yi Katz, Jaqueline Klenk, H. D. Kobinger, Gary Liu, Jinhua Liu, Xiufan Lowen, Anice Metten-Leiter, Thomas C. Osterhaus, Albert D. M. E. Palese, Peter Peiris, J. S. Malik Perez, Daniel R. Richt, Juergen A. Schultz-Cherry, Stacey Steel, John Subbarao, Kanta Swayne, David E. Takimoto, Toru Tashiro, Masato Taubenberger, Jeffery K. Thomas, Paul G. Tripp, Ralph A. Tumpey, Terrence M. Webby, Richard J. Webster, Robert G. TI Pause on Avian Flu Transmission Research SO SCIENCE LA English DT Letter C1 [Fouchier, Ron A. M.; Osterhaus, Albert D. M. E.] Erasmus MC, Dept Virol, NL-3015 GE Rotterdam, Netherlands. [Bouvier, Nicole M.] Mt Sinai Sch Med, Dept Microbiol, Sch Med, New York, NY 10029 USA. [Kawaoka, Yoshihiro] Univ Wisconsin, Dept Pathobiol Sci, Sch Vet Med, Madison, WI 53711 USA. [Barclay, Wendy S.] Univ London Imperial Coll Sci Technol & Med, Dept Med, London, England. [Bouvier, Nicole M.] Mt Sinai Sch Med, Div Infect Dis, Sch Med, New York, NY 10029 USA. [Brown, Ian H.] Anim Hlth & Vet Labs Agcy, Dept Virol, Addlestone KT15, Surrey, England. [Capua, Ilaria] Ist Zooprofilatt Sperimentale Venezie, I-35020 Padua, Italy. [Chen, Hualan] CAAS, Harbin Vet Res Inst, Harbin 150001, Peoples R China. [Compans, Richard W.] Emory Univ, Sch Med, Influenza Pathogenesis & Immunol Res Ctr, Atlanta, GA 30322 USA. [Couch, Robert B.] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA. [Donis, Ruben O.] Ctr Dis Control & Prevent, Influenza Div, Mol Virol & Vaccines Branch, Atlanta, GA 30333 USA. [Doherty, Peter C.] St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA. [Feldmann, Heinz] NIAID, Virol Lab, NIH, Rocky Mt Labs, Hamilton, MT 59840 USA. [Guan, Yi] Univ Hong Kong, State Key Lab Emerging Infect Dis, Hong Kong, Hong Kong, Peoples R China. [Katz, Jaqueline] Ctr Dis Control & Prevent, Immunol & Pathogenesis Branch, Influenza Div, Atlanta, GA 30333 USA. [Klenk, H. D.] Inst Virol, D-35043 Marburg, Germany. [Kobinger, Gary] Publ Hlth Agcy Canada, Natl Microbiol Lab, Winnipeg, MB R3E 3R2, Canada. [Liu, Jinhua] China Agr Univ, Dept Preventat Vet Med, Beijing 100094, Peoples R China. [Liu, Xiufan] Yangzhou Univ, Anim Infect Dis Lab, Sch Vet Med, Yangzhou 225009, Jiangsu, Peoples R China. [Lowen, Anice] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA. [Metten-Leiter, Thomas C.] Friedrich Loeffler Inst, D-17493 Greifswald, Germany. [Palese, Peter] Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA. [Peiris, J. S. Malik] Univ Hong Kong, Dept Microbiol, Pokfulam, Hong Kong, Peoples R China. [Peiris, J. S. Malik] Univ Hong Kong, HKU Pasteur Res Ctr, Pokfulam, Hong Kong, Peoples R China. [Perez, Daniel R.] Univ Maryland, Dept Vet Med, College Pk, MD 20742 USA. [Richt, Juergen A.] Kansas State Univ, Coll Vet Med, Manhattan, KS 66506 USA. [Schultz-Cherry, Stacey] St Jude Childrens Hosp, Dept Infect Dis, Memphis, TN 38105 USA. [Steel, John] Emory Univ, Dept Microbiol & Immunol, Sch Med, Atlanta, GA 30322 USA. [Subbarao, Kanta] NIAID, Emerging Resp Viruses Sect, Infect Dis Lab, NIH, Bethesda, MD 20892 USA. [Swayne, David E.] ARS, SE Poultry Res Lab, USDA, Athens, GA 30605 USA. [Takimoto, Toru] Univ Rochester, Med Ctr, Dept Microbiol & Immunol, Rochester, NY 14642 USA. [Tashiro, Masato] Natl Inst Infect Dis, Influenza Virus Res Ctr, Tokyo 208001, Japan. [Taubenberger, Jeffery K.] NIAID, Viral Pathogenesis & Evolut Sect, Lab Infect Dis, NIH, Bethesda, MD 20892 USA. [Thomas, Paul G.] St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA. [Tripp, Ralph A.] Univ Georgia, Dept Infect Dis, Coll Vet Med, Athens, GA 30602 USA. [Tumpey, Terrence M.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA. [Webster, Robert G.] St Jude Childrens Hosp, Dept Infect Dis, Div Virol, Memphis, TN 38105 USA. RP Fouchier, RAM (reprint author), Erasmus MC, Dept Virol, 3000CA Rotterdam, NL-3015 GE Rotterdam, Netherlands. EM r.fouchier@erasmusmc.nl RI Compans, Richard/I-4087-2013; Brown, Ian/E-1119-2011; APHA, Staff publications/E-6082-2010; Fouchier, Ron/A-1911-2014; Doherty, Peter Charles/C-4185-2013; OI Thomas, Paul G./0000-0001-7955-0256; Perez, Daniel/0000-0002-6569-5689; Compans, Richard/0000-0003-2360-335X; Fouchier, Ron/0000-0001-8095-2869; Tripp, Ralph/0000-0002-2924-9956; Bouvier, Nicole/0000-0002-4530-2841; Doherty, Peter Charles/0000-0002-5028-3489; Osterhaus, Albert/0000-0002-6074-1172; Palese, Peter/0000-0002-0337-5823; Garcia-Sastre, Adolfo/0000-0002-6551-1827 FU Intramural NIH HHS [Z01 AI000986-01] NR 0 TC 35 Z9 38 U1 1 U2 29 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 J9 SCIENCE JI Science PD JAN 27 PY 2012 VL 335 IS 6067 BP 400 EP 401 DI 10.1126/science.1219412 PG 2 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 881FG UT WOS:000299466800019 PM 22282787 ER PT J AU Mereckiene, J Cotter, S Weber, JT Nicoll, A D'Ancona, F Lopalco, PL Johansen, K Wasley, AM Jorgensen, P Levy-Bruhl, D Giambi, C Stefanoff, P Dematte, L O'Flanagan, D AF Mereckiene, J. Cotter, S. Weber, J. T. Nicoll, A. D'Ancona, F. Lopalco, P. L. Johansen, K. Wasley, A. M. Jorgensen, P. Levy-Bruhl, D. Giambi, C. Stefanoff, P. Dematte, L. O'Flanagan, D. CA VENICE Project Gatekeepers Grp TI Influenza A(H1N1)pdm09 vaccination policies and coverage in Europe SO EUROSURVEILLANCE LA English DT Article ID PANDEMIC H1N1 2009; RANDOMIZED CONTROLLED-TRIAL; HEALTH-CARE WORKERS; A H1N1; IMMUNIZATION; AUSTRALIA; OUTCOMES AB In August 2010 the Vaccine European New Integrated Collaboration Effort (VENICE) project conducted a survey to collect information on influenza A(H1N1) pdm09 vaccination policies and vaccination coverage in the European Union (EU), Norway and Iceland. Of 29 responding countries, 26 organised national pandemic influenza vaccination and one country had recommendations for vaccination but did not have a specific programme. Of the 27 countries with vaccine recommendations, all recommended it for healthcare workers and pregnant women. Twelve countries recommended vaccine for all ages. Six and three countries had recommendations for specific age groups in children and in adults, countries for specific adult age groups. Most countries recommended vaccine for those in new risk groups identified early in the pandemic such as morbid obese and people with neurologic diseases. Two thirds of countries started their vaccination campaigns within a four week period after week 40/2009. The reported vaccination coverage varied between countries from 0.4% to 59% for the entire population (22 countries); 3% to 68% for healthcare workers (13 countries); 0% to 58% for pregnant women (12 countries); 0.2% to 74% for children (12 countries). Most countries identified similar target groups for pandemic vaccine, but substantial variability in vaccination coverage was seen. The recommendations were in accordance with policy advice from the EU Health Security Committee and the World Health Organization. C1 [Mereckiene, J.; Cotter, S.; O'Flanagan, D.] Hlth Protect Surveillance Ctr, Dublin, Ireland. [Mereckiene, J.; Cotter, S.; D'Ancona, F.; Levy-Bruhl, D.; Giambi, C.; Stefanoff, P.; Dematte, L.; O'Flanagan, D.] Vaccine European New Integrated Collaborat Effort, Venice, Italy. [Weber, J. T.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Nicoll, A.; Lopalco, P. L.; Johansen, K.] European Ctr Dis Prevent & Control ECDC, Stockholm, Sweden. [D'Ancona, F.; Giambi, C.] Ist Super Sanita, Natl Inst Hlth, I-00161 Rome, Italy. [Wasley, A. M.; Jorgensen, P.] WHO, Off Europe, Copenhagen, Denmark. [Levy-Bruhl, D.] InVS, French Inst Publ Hlth Surveillance, Inst Veille Sanitaire, St Maurice, France. [Stefanoff, P.] Natl Inst Hyg, Natl Inst Publ Hlth, PL-00791 Warsaw, Poland. [Dematte, L.] CINECA Consortium Univ, Bologna, Italy. RP Mereckiene, J (reprint author), Hlth Protect Surveillance Ctr, Dublin, Ireland. EM jolita.mereckiene@hse.ie RI D'Ancona, Fortunato/B-2139-2013; Stefanoff, Pawel/E-5506-2013 OI D'Ancona, Fortunato/0000-0002-9855-2924; Stefanoff, Pawel/0000-0003-0087-0906 FU European Centre for Disease Prevention and Control (ECDC) FX This study was conducted within the European Centre for Disease Prevention and Control (ECDC) funded Vaccine European New Integrated Collaboration Effort (VENICE) 2 project. NR 43 TC 19 Z9 19 U1 0 U2 2 PU EUR CENTRE DIS PREVENTION & CONTROL PI STOCKHOLM PA TOMTEBODAVAGEN 11A, STOCKHOLM, 171 83, SWEDEN SN 1560-7917 J9 EUROSURVEILLANCE JI Eurosurveillance PD JAN 26 PY 2012 VL 17 IS 4 BP 18 EP 27 AR 20064 PG 10 WC Infectious Diseases SC Infectious Diseases GA 886AO UT WOS:000299822800004 ER PT J AU Pearson, ML Selby, JV Katz, KA Cantrell, V Braden, CR Parise, ME Paddock, CD Lewin-Smith, MR Kalasinsky, VF Goldstein, FC Hightower, AW Papier, A Lewis, B Motipara, S Eberhard, ML AF Pearson, Michele L. Selby, Joseph V. Katz, Kenneth A. Cantrell, Virginia Braden, Christopher R. Parise, Monica E. Paddock, Christopher D. Lewin-Smith, Michael R. Kalasinsky, Victor F. Goldstein, Felicia C. Hightower, Allen W. Papier, Arthur Lewis, Brian Motipara, Sarita Eberhard, Mark L. CA Unexplained Dermopathy Study Team TI Clinical, Epidemiologic, Histopathologic and Molecular Features of an Unexplained Dermopathy SO PLOS ONE LA English DT Article ID STREPTOCOCCUS-PNEUMONIAE; BRACHIORADIAL PRURITUS; MEDICAL OUTCOMES; PARASITOSIS; DELUSIONS; DIAGNOSIS; CULTURE; TISSUE; PCR AB Background: Morgellons is a poorly characterized constellation of symptoms, with the primary manifestations involving the skin. We conducted an investigation of this unexplained dermopathy to characterize the clinical and epidemiologic features and explore potential etiologies. Methods: A descriptive study was conducted among persons at least 13 years of age and enrolled in Kaiser Permanente Northern California (KPNC) during 2006-2008. A case was defined as the self-reported emergence of fibers or materials from the skin accompanied by skin lesions and/or disturbing skin sensations. We collected detailed epidemiologic data, performed clinical evaluations and geospatial analyses and analyzed materials collected from participants' skin. Results: We identified 115 case-patients. The prevalence was 3.65 (95% CI = 2.98, 4.40) cases per 100,000 enrollees. There was no clustering of cases within the 13-county KPNC catchment area (p = .113). Case-patients had a median age of 52 years (range: 17-93) and were primarily female (77%) and Caucasian (77%). Multi-system complaints were common; 70% reported chronic fatigue and 54% rated their overall health as fair or poor with mean Physical Component Scores and Mental Component Scores of 36.63 (SD = 12.9) and 35.45 (SD = 12.89), respectively. Cognitive deficits were detected in 59% of case-patients and 63% had evidence of clinically significant somatic complaints; 50% had drugs detected in hair samples and 78% reported exposure to solvents. Solar elastosis was the most common histopathologic abnormality (51% of biopsies); skin lesions were most consistent with arthropod bites or chronic excoriations. No parasites or mycobacteria were detected. Most materials collected from participants' skin were composed of cellulose, likely of cotton origin. Conclusions: This unexplained dermopathy was rare among this population of Northern California residents, but associated with significantly reduced health-related quality of life. No common underlying medical condition or infectious source was identified, similar to more commonly recognized conditions such as delusional infestation. C1 [Pearson, Michele L.] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA USA. [Selby, Joseph V.; Cantrell, Virginia; Motipara, Sarita] Kaiser Permanente No Calif, Div Res, Oakland, CA USA. [Katz, Kenneth A.] Hlth & Human Serv Agcy, HIV STD & Hepatitis Branch, San Diego, CA USA. [Braden, Christopher R.] Ctr Dis Control & Prevent, Div Food Waterborne & Environm Dis, Atlanta, GA USA. [Parise, Monica E.; Hightower, Allen W.; Eberhard, Mark L.] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA USA. [Paddock, Christopher D.] Ctr Dis Control & Prevent, Div High Consequence Pathogens & Pathol, Atlanta, GA USA. [Lewin-Smith, Michael R.] Joint Pathol Ctr, Silver Spring, MD USA. [Kalasinsky, Victor F.] US Dept Vet Affairs, Off Res & Dev, Washington, DC USA. [Goldstein, Felicia C.] Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA. [Papier, Arthur] Univ Rochester, Sch Med, Dept Dermatol, Rochester, NY USA. [Lewis, Brian] Agcy Tox Subst & Dis Registry, Div Hlth Studies, Atlanta, GA USA. RP Pearson, ML (reprint author), Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA USA. EM mle1@cdc.gov FU Centers for Disease Control (CDC) and Prevention FX Funding for this study was provided by the Centers for Disease Control (CDC) and Prevention. Epidemiologists from the CDC participated in the study design, data collection and analysis, decision to publish, and preparation of the manuscript. NR 31 TC 27 Z9 27 U1 0 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 25 PY 2012 VL 7 IS 1 AR e29908 DI 10.1371/journal.pone.0029908 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 910ME UT WOS:000301640600015 PM 22295070 ER PT J AU Prescott, K Kroona, S Quinlisk, P Gipple, D Garvey, A Desjardin, L Jirsa, S Benfer, J Gomez, T Finelli, L Jhung, MA Jain, S Brammer, L Epperson, S Bresee, J Klimov, A Emery, S Lindstrom, S Trock, S Jernigan, D Cox, N Wong, K Greenbaum, A Storms, A Garg, S AF Prescott, Kari Kroona, Shelby Quinlisk, Patricia Gipple, Denyse Garvey, Ann Desjardin, Lucy Jirsa, Sandy Benfer, Jeff Gomez, Thomas Finelli, Lyn Jhung, Michael A. Jain, Seema Brammer, Lynnette Epperson, Scott Bresee, Joseph Klimov, Alexander Emery, Shannon Lindstrom, Stephen Trock, Susan Jernigan, Daniel Cox, Nancy Wong, Karen Greenbaum, Adena Storms, Aaron Garg, Shikha TI Limited Human-to-Human Transmission of Novel Influenza A (H3N2) Virus-Iowa, November 2011 (Reprinted from MMWR, vol 60, pg 1615-1617, 2011) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint ID SWINE INFLUENZA; UNITED-STATES; INFECTION; SEASON C1 [Prescott, Kari] Webster Cty Hlth Dept, Ft Dodge, IA USA. [Kroona, Shelby] Hamilton Cty Publ Hlth, Webster, NY USA. [Quinlisk, Patricia; Gipple, Denyse; Garvey, Ann] Iowa Dept Publ Hlth, Des Moines, IA 50319 USA. [Jirsa, Sandy; Benfer, Jeff] Univ Iowa, State Hygien Lab, Iowa City, IA 52242 USA. [Gomez, Thomas] USDA, Anim & Plant Hlth Inspect Svc, Washington, DC USA. [Greenbaum, Adena; Storms, Aaron; Garg, Shikha] CDC, Atlanta, GA 30333 USA. EM mjhung@cdc.gov NR 8 TC 0 Z9 0 U1 0 U2 3 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JAN 25 PY 2012 VL 307 IS 4 BP 354 EP 357 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 881EP UT WOS:000299464000008 ER PT J AU Ford, ES AF Ford, Earl S. TI Combined television viewing and computer use and mortality from all-causes and diseases of the circulatory system among adults in the United States SO BMC PUBLIC HEALTH LA English DT Article DE Mortality; Sedentary lifestyle; Television ID NATIONAL DEATH INDEX; TYPE-2 DIABETES-MELLITUS; PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE; SEDENTARY BEHAVIOR; METABOLIC SYNDROME; FOLLOW-UP; TIME; RISK; CANCER AB Background: Watching television and using a computer are increasingly common sedentary behaviors. Whether or not prolonged screen time increases the risk for mortality remains uncertain. Methods: Mortality for 7,350 adults aged >= 20 years who participated in the National Health and Nutrition Examination Survey during 1999-2002 and were followed through 2006 was examined. Participants were asked a single question about the amount of time they spent watching television or videos or using a computer during the past 30 days. Results: During a median follow-up of 5.8 years, 542 participants died. At baseline, 12.7% of participants reported watching television or using a computer less than 1 h per day, 16.4% did so for 1 h, 27.8% for 2 h, 18.7% for 3 h, 10.9% for 4 h, and 13.5% for 5 or more h. After extensive adjustment, the hazard ratio for all-cause mortality for the top category of exposure was 1.30 (95% confidence interval: 0.82, 2.05). No significant trend across categories of exposure was noted. The amount of screen time was also not significantly related to mortality from diseases of the circulatory system. Conclusions: In the present study, screen time did not significantly predict mortality from all-causes and diseases of the circulatory system. C1 [Ford, Earl S.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Ford, Earl S.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. RP Ford, ES (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. EM eford@cdc.gov NR 27 TC 17 Z9 17 U1 1 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD JAN 23 PY 2012 VL 12 AR 70 DI 10.1186/1471-2458-12-70 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 908XG UT WOS:000301525800002 PM 22269463 ER PT J AU Periago, MR Frieden, TR Tappero, JW De Cock, KM Aasen, B Andrus, JK AF Periago, Mirta Roses Frieden, Thomas R. Tappero, Jordan W. De Cock, Kevin M. Aasen, Bernt Andrus, Jon K. TI Elimination of cholera transmission in Haiti and the Dominican Republic SO LANCET LA English DT Editorial Material ID INTERVENTIONS; BENEFITS; MEXICO C1 [Periago, Mirta Roses; Andrus, Jon K.] Pan Amer Hlth Org, Washington, DC 20037 USA. [Frieden, Thomas R.] Ctr Dis Control & Prevent, Off Director, Atlanta, GA USA. [Tappero, Jordan W.; De Cock, Kevin M.] Ctr Dis Control & Prevent, Ctr Global Hlth, Atlanta, GA USA. [Aasen, Bernt] United Nations Childrens Fund, Latin Amer & Caribbean Off, Panama City, Panama. RP Andrus, JK (reprint author), Pan Amer Hlth Org, Washington, DC 20037 USA. EM andrusjo@paho.org NR 13 TC 19 Z9 19 U1 0 U2 18 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0140-6736 J9 LANCET JI Lancet PD JAN 21 PY 2012 VL 379 IS 9812 BP E12 EP E13 DI 10.1016/S0140-6736(12)60031-2 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 879FW UT WOS:000299316100001 PM 22240408 ER PT J AU Santibanez, TA Shefer, A Briere, EC Cohn, AC Groom, AV AF Santibanez, Tammy A. Shefer, Abigail Briere, Elizabeth C. Cohn, Amanda C. Groom, Amy V. TI Effects of a nationwide Hib vaccine shortage on vaccination coverage in the United States SO VACCINE LA English DT Article DE Haemophilus influenzae type b (Hib); Vaccination coverage; Vaccine shortages ID PNEUMOCOCCAL CONJUGATE VACCINE; IMMUNIZATION SURVEY; RECOMMENDATIONS AB Background: A shortage of Haemophilus influenzae type b (Hib) vaccine that occurred in the United States during December 2007 to September 2009 resulted in an interim recommendation to defer the booster dose, but to continue to vaccinate as recommended with the primary series during the first year of life. Objectives: To quantify effects of the Hib shortage on vaccination coverage and to determine if any demographic subgroups were disproportionately affected. Methods: Data from the 2009 National Immunization Survey (NIS) were divided based on child's age at the onset of the shortage. Comparisons were made in primary series coverage by 9 months between children <7 months versus >= 7 months at the start of the shortage. Comparisons in primary series plus booster dose completion by 19 months were made between children who were <12 months versus >= 12 months at the start of the shortage. Results: Nationally, there was a difference in Hib primary series completion by 9 months among children age <7 months versus >= 7 months at the start of the shortage (73.9% versus 81.2%, P<0.001). There was a large difference in the percentage of children fully vaccinated with the primary series plus booster dose by 19 months among children age <12 months versus >= 12 months at the start of the shortage (39.5% versus 66.0%, P<0.001). There were differential effects of the shortage on primary series coverage among states and for some demographic characteristics. Conclusions: As expected booster dose coverage was reduced consistent with interim recommendations, but primary series coverage was also reduced by 7 percentage points nationally. Published by Elsevier Ltd. C1 [Santibanez, Tammy A.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Santibanez, TA (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,Mail Stop A-19, Atlanta, GA 30333 USA. EM afz5@cdc.gov NR 22 TC 11 Z9 11 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JAN 20 PY 2012 VL 30 IS 5 BP 941 EP 947 DI 10.1016/j.vaccine.2011.11.075 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 909IK UT WOS:000301558000019 PM 22137879 ER PT J AU Ekouevi, DK Stringer, E Coetzee, D Tih, P Creek, T Stinson, K Westfall, AO Welty, T Chintu, N Chi, BH Wilfert, C Shaffer, N Stringer, J Dabis, F AF Ekouevi, Didier K. Stringer, Elizabeth Coetzee, David Tih, Pius Creek, Tracy Stinson, Kathryn Westfall, Andrew O. Welty, Thomas Chintu, Namwinga Chi, Benjamin H. Wilfert, Cathy Shaffer, Nathan Stringer, Jeff Dabis, Francois TI Health Facility Characteristics and Their Relationship to Coverage of PMTCT of HIV Services across Four African Countries: The PEARL Study SO PLOS ONE LA English DT Article ID TO-CHILD TRANSMISSION; PREVENTION AB Background: Health facility characteristics associated with effective prevention of mother-to-child transmission of HIV (PMTCT) coverage in sub-Saharan are poorly understood. Methodology/Principal Findings: We conducted surveys in health facilities with active PMTCT services in Cameroon, Cote d'Ivoire, South Africa, and Zambia. Data was compiled via direct observation and exit interviews. We constructed composite scores to describe provision of PMTCT services across seven topical areas: antenatal quality, PMTCT quality, supplies available, patient satisfaction, patient understanding of medication, and infrastructure quality. Pearson correlations and Generalized Estimating Equations (GEE) to account for clustering of facilities within countries were used to evaluate the relationship between the composite scores, total time of visit and select individual variables with PMTCT coverage among women delivering. Between July 2008 and May 2009, we collected data from 32 facilities; 78% were managed by the government health system. An opt-out approach for HIV testing was used in 100% of facilities in Zambia, 63% in Cameroon, and none in Cote d'Ivoire or South Africa. Using Pearson correlations, PMTCT coverage (median of 55%, (IQR: 33-68) was correlated with PMTCT quality score (rho = 0.51; p = 0.003); infrastructure quality score (rho = 0.43; p = 0.017); time spent at clinic (rho = 0.47; p = 0.013); patient understanding of medications score (rho = 0.51; p = 0.006); and patient satisfaction quality score (rho = 0.38; p = 0.031). PMTCT coverage was marginally correlated with the antenatal quality score (rho = 0.304; p = 0.091). Using GEE adjustment for clustering, the, antenatal quality score became more strongly associated with PMTCT coverage (p<0.001) and the PMTCT quality score and patient understanding of medications remained marginally significant. Conclusions/Results: We observed a positive relationship between an antenatal quality score and PMTCT coverage but did not identify a consistent set of variables that predicted PMTCT coverage. C1 [Ekouevi, Didier K.; Welty, Thomas] Programme PAC CI, Abidjan, Cote Ivoire. [Ekouevi, Didier K.; Welty, Thomas; Dabis, Francois] Univ Victor Segalen, Inst Natl Sante & Rech Med, Bordeaux, France. [Stringer, Elizabeth; Westfall, Andrew O.; Chintu, Namwinga; Chi, Benjamin H.; Stringer, Jeff] Ctr Infect Dis Res Zambia, Lusaka, Zambia. [Coetzee, David; Stinson, Kathryn] Univ Cape Town, ZA-7925 Cape Town, South Africa. [Tih, Pius] Cameroon Baptist Hlth Convent Hlth Board, Bamenda, Cameroon. [Creek, Tracy] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Wilfert, Cathy] Elizabeth Glaser Pediat AIDS Fdn, Washington, DC USA. [Shaffer, Nathan] World Hlth Org, Geneva, Switzerland. RP Ekouevi, DK (reprint author), Programme PAC CI, Abidjan, Cote Ivoire. EM didier.ekouevi@gmail.com RI EKOUEVI, Didier/E-7960-2014; OI Westfall, Andrew/0000-0002-0468-4695 FU U.S. Centers for Disease Control and Prevention [T0906150021/CDC-Centers for Disease Control/EGPAF AM3]; Elizabeth Glaser Pediatric AIDS Foundation from the Bill and Melinda Gates Foundation [351-07] FX This study was supported by the U.S. Centers for Disease Control and Prevention, Global AIDS Program of Atlanta, Georgia (Contract T0906150021/CDC-Centers for Disease Control/EGPAF AM3) and by the Elizabeth Glaser Pediatric AIDS Foundation (grant number #351-07 from the Bill and Melinda Gates Foundation). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 10 TC 18 Z9 18 U1 0 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 20 PY 2012 VL 7 IS 1 AR e29823 DI 10.1371/journal.pone.0029823 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 909MH UT WOS:000301568100016 PM 22276130 ER PT J AU Finlay, A Lancaster, J Holtz, TH Weyer, K Miranda, A van der Walt, M AF Finlay, Alyssa Lancaster, Joey Holtz, Timothy H. Weyer, Karin Miranda, Abe van der Walt, Martie TI Patient- and provider-level risk factors associated with default from tuberculosis treatment, South Africa, 2002: a case-control study SO BMC PUBLIC HEALTH LA English DT Article DE Tuberculosis; treatment default; non-adherence; South Africa ID DIRECTLY OBSERVED THERAPY; NEW-YORK-CITY; TRADITIONAL HEALERS; RURAL DISTRICT; ANTITUBERCULOSIS TREATMENT; TREATMENT INTERRUPTION; ADHERENCE; TB; CARE; PROGRAM AB Background: Persons who default from tuberculosis treatment are at risk for clinical deterioration and complications including worsening drug resistance and death. Our objective was to identify risk factors associated with tuberculosis (TB) treatment default in South Africa. Methods: We conducted a national retrospective case control study to identify factors associated with treatment default using program data from 2002 and a standardized patient questionnaire. We defined default as interrupting TB treatment for two or more consecutive months during treatment. Cases were a sample of registered TB patients receiving treatment under DOTS that defaulted from treatment. Controls were those who began therapy and were cured, completed or failed treatment. Two respective multivariable models were constructed, stratified by history of TB treatment (new and re-treatment patients), to identify independent risk factors associated with default. Results: The sample included 3165 TB patients from 8 provinces; 1164 were traceable and interviewed (232 cases and 932 controls). Significant risk factors associated with default among both groups included poor health care worker attitude (new: AOR 2.1, 95% CI 1.1-4.4; re-treatment: AOR 12, 95% CI 2.2-66.0) and changing residence during TB treatment (new: AOR 2.0, 95% CI 1.1-3.7; re-treatment: AOR 3.4, 95% CI 1.1-9.9). Among new patients, cases were more likely than controls to report having no formal education (AOR 2.3, 95% CI 1.2-4.2), feeling ashamed to have TB (AOR 2.0, 95% CI 1.3-3.0), not receiving adequate counseling about their treatment (AOR 1.9, 95% CI 1.2-2.8), drinking any alcohol during TB treatment (AOR 1.9, 95% CI 1.2-3.0), and seeing a traditional healer during TB treatment (AOR 1.9, 95% CI 1.1-3.4). Among re-treatment patients, risk factors included stopping TB treatment because they felt better (AOR 21, 95% CI 5.2-84), having a previous history of TB treatment default (AOR 6.4, 95% CI 2.9-14), and feeling that food provisions might have helped them finish treatment (AOR 5.0, 95% CI 1.3-19). Conclusions: Risk factors for default differ between new and re-treatment TB patients in South Africa. Addressing default in both populations with targeted interventions is critical to overall program success. C1 [Finlay, Alyssa; Holtz, Timothy H.; Miranda, Abe] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA. [Lancaster, Joey; van der Walt, Martie] MRC, TB Epidemiol & Intervent Res Unit, ZA-0001 Pretoria, South Africa. [Weyer, Karin] WHO, Stop TB Dept, CH-1211 Geneva 27, Switzerland. RP Finlay, A (reprint author), Ctr Dis Control & Prevent, Div TB Eliminat, 1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM avf0@cdc.gov FU United States Agency of International Development (USAID) FX We would like to thank the eight provincial Departments of Health for their approval and assistance in conducting this study. We also thank Charles D. Wells, Kayla F. Laserson, Malebo Pooe, Peta Davis, Joanne Kirsten, William Coggin all of whom played important roles in facilitating and guiding the planning and implementation of this study. We thank all of our study interviewers who worked so hard to trace patients and conduct interviews. The study was entirely financed by the United States Agency of International Development (USAID), a U.S. government agency providing economic and humanitarian assistance. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 52 TC 17 Z9 17 U1 1 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD JAN 20 PY 2012 VL 12 AR 56 DI 10.1186/1471-2458-12-56 PG 12 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 909ZK UT WOS:000301606700001 PM 22264339 ER PT J AU Kalb, SR Baudys, J Webb, RP Wright, P Smith, TJ Smith, LA Fernandez, R Raphael, BH Maslanka, SE Pirkle, JL Barr, JR AF Kalb, Suzanne R. Baudys, Jakub Webb, Robert P. Wright, Patrick Smith, Theresa J. Smith, Leonard A. Fernandez, Rafael Raphael, Brian H. Maslanka, Susan E. Pirkle, James L. Barr, John R. TI Discovery of a novel enzymatic cleavage site for botulinum neurotoxin F5 SO FEBS LETTERS LA English DT Article DE Botulinum neurotoxin; BoNT/F; Synaptobrevin-2; Mass spectrometry ID CLOSTRIDIAL NEUROTOXINS; SUBSTRATE RECOGNITION; MASS-SPECTROMETRY; SEROTYPE-A; SNAP-25; VAMP/SYNAPTOBREVIN; DIFFERENTIATION; PROTEOLYSIS; TETANUS; RELEASE AB Botulinum neurotoxins (BoNTs) cause botulism by cleaving proteins necessary for nerve transmission. There are seven serotypes of BoNT, A-G, characterized by their response to antisera. Many serotypes are further distinguished into differing subtypes based on amino acid sequence, some of which result in functional differences. Our laboratory previously reported that all tested subtypes within each serotype have the same site of enzymatic activity. Recently, three new subtypes of BoNT/F; /F3, /F4, and /F5, were reported. Here, we report that BoNT/F5 cleaves substrate synaptobrevin-2 in a different location than the other BoNT/F subtypes, between 54L and 55E. This is the first report of cleavage of synaptobrevin-2 in this location. C1 [Kalb, Suzanne R.; Baudys, Jakub; Pirkle, James L.; Barr, John R.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30341 USA. [Webb, Robert P.; Wright, Patrick; Smith, Theresa J.] USAMRIID, Ft Detrick, MD 21702 USA. [Smith, Leonard A.] Med Res & Mat Command MRMC, Off Chief Scientist, Ft Detrick, MD 21702 USA. [Fernandez, Rafael] Univ Nacl Cuyo, Area Microbiol, RA-5500 Mendoza, Argentina. [Raphael, Brian H.; Maslanka, Susan E.] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Enter Dis Lab Branch, Atlanta, GA 30329 USA. RP Barr, JR (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, 4770 Buford Hwy NE, Atlanta, GA 30341 USA. EM jbarr@cdc.gov OI Kalb, Suzanne/0000-0002-8067-136X; Raphael, Brian/0000-0003-2778-2623 FU NIAID IAA [120-B18] FX This work was supported by NIAID IAA 120-B18. The opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the Centers for Disease Control and Prevention, the U.S. Army, the National Institute of Allergy and Infectious Diseases, or the National Institutes of Health. NR 24 TC 26 Z9 26 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0014-5793 J9 FEBS LETT JI FEBS Lett. PD JAN 20 PY 2012 VL 586 IS 2 BP 109 EP 115 DI 10.1016/j.febslet.2011.11.033 PG 7 WC Biochemistry & Molecular Biology; Biophysics; Cell Biology SC Biochemistry & Molecular Biology; Biophysics; Cell Biology GA 882DH UT WOS:000299541200001 PM 22172278 ER PT J AU Breiman, RF Cosmas, L Njuguna, H Audi, A Olack, B Ochieng, JB Wamola, N Bigogo, GM Awiti, G Tabu, CW Burke, H Williamson, J Oundo, JO Mintz, ED Feikin, DR AF Breiman, Robert F. Cosmas, Leonard Njuguna, Henry Audi, Allan Olack, Beatrice Ochieng, John B. Wamola, Newton Bigogo, Godfrey M. Awiti, George Tabu, Collins W. Burke, Heather Williamson, John Oundo, Joseph O. Mintz, Eric D. Feikin, Daniel R. TI Population-Based Incidence of Typhoid Fever in an Urban Informal Settlement and a Rural Area in Kenya: Implications for Typhoid Vaccine Use in Africa SO PLOS ONE LA English DT Article ID SALMONELLA-TYPHI; INVASIVE BACTERIAL; NORTHERN TANZANIA; FUNGAL-INFECTIONS; DISEASE BURDEN; UNITED-STATES; BONE-MARROW; CHILDREN; BACTEREMIA; PAKISTAN AB Background: High rates of typhoid fever in children in urban settings in Asia have led to focus on childhood immunization in Asian cities, but not in Africa, where data, mostly from rural areas, have shown low disease incidence. We set out to compare incidence of typhoid fever in a densely populated urban slum and a rural community in Kenya, hypothesizing higher rates in the urban area, given crowding and suboptimal access to safe water, sanitation and hygiene. Methods: During 2007-9, we conducted population-based surveillance in Kibera, an urban informal settlement in Nairobi, and in Lwak, a rural area in western Kenya. Participants had free access to study clinics; field workers visited their homes biweekly to collect information about acute illnesses. In clinic, blood cultures were processed from patients with fever or pneumonia. Crude and adjusted incidence rates were calculated. Results: In the urban site, the overall crude incidence of Salmonella enterica serovar Typhi (S. Typhi) bacteremia was 247 cases per 100,000 person-years of observation (pyo) with highest rates in children 5-9 years old (596 per 100,000 pyo) and 2-4 years old (521 per 100,000 pyo). Crude overall incidence in Lwak was 29 cases per 100,000 pyo with low rates in children 2-4 and 5-9 years old (28 and 18 cases per 100,000 pyo, respectively). Adjusted incidence rates were highest in 2-4 year old urban children (2,243 per 100,000 pyo) which were >15-fold higher than rates in the rural site for the same age group. Nearly 75% of S. Typhi isolates were multi-drug resistant. Conclusions: This systematic urban slum and rural comparison showed dramatically higher typhoid incidence among urban children,10 years old with rates similar to those from Asian urban slums. The findings have potential policy implications for use of typhoid vaccines in increasingly urban Africa. C1 [Breiman, Robert F.; Cosmas, Leonard; Njuguna, Henry; Audi, Allan; Olack, Beatrice; Ochieng, John B.; Wamola, Newton; Bigogo, Godfrey M.; Awiti, George; Burke, Heather; Williamson, John; Oundo, Joseph O.; Feikin, Daniel R.] US Ctr Dis Control & Prevent, Global Dis Detect Div, Kenya Off, Nairobi, Kenya. [Breiman, Robert F.; Cosmas, Leonard; Njuguna, Henry; Audi, Allan; Olack, Beatrice; Ochieng, John B.; Wamola, Newton; Bigogo, Godfrey M.; Awiti, George; Burke, Heather; Williamson, John; Oundo, Joseph O.; Feikin, Daniel R.] US Ctr Dis Control & Prevent, Global Dis Detect Div, Kenya Off, Kisumu, Kenya. [Cosmas, Leonard; Njuguna, Henry; Audi, Allan; Olack, Beatrice; Ochieng, John B.; Wamola, Newton; Bigogo, Godfrey M.; Awiti, George] Kenya Med Res Inst KEMRI, Nairobi, Kenya. [Cosmas, Leonard; Njuguna, Henry; Audi, Allan; Olack, Beatrice; Ochieng, John B.; Wamola, Newton; Bigogo, Godfrey M.; Awiti, George] Kenya Med Res Inst KEMRI, Kisumu, Kenya. [Tabu, Collins W.] Kenya Minist Publ Hlth & Sanitat, Nairobi, Kenya. [Mintz, Eric D.] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. RP Breiman, RF (reprint author), US Ctr Dis Control & Prevent, Global Dis Detect Div, Kenya Off, Nairobi, Kenya. EM rbreiman@ke.cdc.gov NR 42 TC 68 Z9 68 U1 1 U2 14 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 19 PY 2012 VL 7 IS 1 AR e29119 DI 10.1371/journal.pone.0029119 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 907YS UT WOS:000301457200006 PM 22276105 ER PT J AU Brammer, L Epperson, S Kniss, K Mustaquim, D Bishop, A Dhara, R Jhung, M Blanton, L Wallis, T Finelli, L Gubareva, L Bresee, J Klimov, A Cox, N Chen, G AF Brammer, Lynnette Epperson, Scott Kniss, Krista Mustaquim, Desiree Bishop, Amber Dhara, Rosaline Jhung, Michael Blanton, Lenee Wallis, Teresa Finelli, Lyn Gubareva, Larisa Bresee, Joseph Klimov, Alexander Cox, Nancy Chen, Grace TI Update: Influenza Activity-United States, October 2-November 26, 2011 (Reprinted from MMWR, vol 60, pg 1646-1649, 2011) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint ID A H3N2 VIRUS; INFECTION; ILLNESS C1 [Chen, Grace] CDC, EIS, Atlanta, GA 30333 USA. RP Chen, G (reprint author), CDC, EIS, Atlanta, GA 30333 USA. EM glchen@cdc.gov NR 9 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JAN 18 PY 2012 VL 307 IS 3 BP 244 EP 247 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 877EY UT WOS:000299161200008 ER PT J AU Cohen, SM Van Handel, MM Branson, BM Blair, JM Hall, HI Hu, XH Koenig, LJ Skarbinski, J Tracey, A Mermin, J Valleroy, LA AF Cohen, Stacy M. Van Handel, Michelle M. Branson, Bernard M. Blair, Janet M. Hall, H. Irene Hu, Xiaohong Koenig, Linda J. Skarbinski, Jacek Tracey, Angie Mermin, Jonathan Valleroy, Linda A. TI Vital Signs: HIV Prevention Through Care and Treatment-United States (Reprinted from MMWR, vol 60, pg 1618-1623, 2011) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint ID MEDICAL-CARE; INFECTION; COST C1 [Cohen, Stacy M.; Van Handel, Michelle M.; Branson, Bernard M.; Blair, Janet M.; Hall, H. Irene; Hu, Xiaohong; Koenig, Linda J.; Skarbinski, Jacek; Tracey, Angie; Mermin, Jonathan; Valleroy, Linda A.] CDC, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. RP Cohen, SM (reprint author), CDC, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. EM scohen@cdc.gov RI Mermin, Jonathan/J-9847-2012 NR 18 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JAN 18 PY 2012 VL 307 IS 3 BP 247 EP 250 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 877EY UT WOS:000299161200009 ER PT J AU Ahmed, JA Katz, MA Auko, E Njenga, MK Weinberg, M Kapella, BK Burke, H Nyoka, R Gichangi, A Waiboci, LW Mahamud, A Qassim, M Swai, B Wagacha, B Mutonga, D Nguhi, M Breiman, RF Eidex, RB AF Ahmed, Jamal A. Katz, Mark A. Auko, Eric Njenga, M. Kariuki Weinberg, Michelle Kapella, Bryan K. Burke, Heather Nyoka, Raymond Gichangi, Anthony Waiboci, Lilian W. Mahamud, Abdirahman Qassim, Mohamed Swai, Babu Wagacha, Burton Mutonga, David Nguhi, Margaret Breiman, Robert F. Eidex, Rachel B. TI Epidemiology of respiratory viral infections in two long-term refugee camps in Kenya, 2007-2010 SO BMC INFECTIOUS DISEASES LA English DT Article ID SYNCYTIAL VIRUS-INFECTION; COMPLEX EMERGENCIES; TRACT INFECTIONS; YOUNG-CHILDREN; PNEUMONIA; HOSPITALIZATIONS; SURVEILLANCE; HEALTH; AGE AB Background: Refugees are at risk for poor outcomes from acute respiratory infections (ARI) because of overcrowding, suboptimal living conditions, and malnutrition. We implemented surveillance for respiratory viruses in Dadaab and Kakuma refugee camps in Kenya to characterize their role in the epidemiology of ARI among refugees. Methods: From 1 September 2007 through 31 August 2010, we obtained nasopharyngeal (NP) and oropharyngeal (OP) specimens from patients with influenza-like illness (ILI) or severe acute respiratory infections (SARI) and tested them by RT-PCR for adenovirus (AdV), respiratory syncytial virus (RSV), human metapneumovirus (hMPV), parainfluenza viruses (PIV), and influenza A and B viruses. Definitions for ILI and SARI were adapted from those of the World Health Organization. Proportions of cases associated with viral aetiology were calculated by camp and by clinical case definition. In addition, for children < 5 years only, crude estimates of rates due to SARI per 1000 were obtained. Results: We tested specimens from 1815 ILI and 4449 SARI patients (median age = 1 year). Proportion positive for virus were AdV, 21.7%; RSV, 12.5%; hMPV, 5.7%; PIV, 9.4%; influenza A, 9.7%; and influenza B, 2.6%; 49.8% were positive for at least one virus. The annual rate of SARI hospitalisation for 2007-2010 was 57 per 1000 children per year. Virus-positive hospitalisation rates were 14 for AdV; 9 for RSV; 6 for PIV; 4 for hMPV; 5 for influenza A; and 1 for influenza B. The rate of SARI hospitalisation was highest in children < 1 year old (156 per 1000 child-years). The ratio of rates for children < 1 year and 1 to < 5 years old was 3.7:1 for AdV, 5.5:1 for RSV, 4.4:1 for PIV, 5.1:1 for hMPV, 3.2:1 for influenza A, and 2.2:1 for influenza B. While SARI hospitalisation rates peaked from November to February in Dadaab, no distinct seasonality was observed in Kakuma. Conclusions: Respiratory viral infections, particularly RSV and AdV, were associated with high rates of illness and make up a substantial portion of respiratory infection in these two refugee settings. C1 [Ahmed, Jamal A.; Katz, Mark A.; Njenga, M. Kariuki; Burke, Heather; Nyoka, Raymond; Gichangi, Anthony; Waiboci, Lilian W.; Breiman, Robert F.; Eidex, Rachel B.] US Ctr Dis Control & Prevent, Nairobi, Kenya. [Auko, Eric; Mahamud, Abdirahman] Kenya Govt Med Res Ctr, Nairobi, Kenya. [Weinberg, Michelle; Kapella, Bryan K.] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Qassim, Mohamed; Swai, Babu; Wagacha, Burton] United Nations High Commissioner Refugees, Nairobi, Kenya. [Mutonga, David] Minist Publ Hlth & Sanitat, Nairobi, Kenya. [Nguhi, Margaret] Int Rescue Comm, Nairobi, Kenya. [Ahmed, Jamal A.] KEMRI Compound, KEMRI CDC, Nairobi 00621, Kenya. RP Ahmed, JA (reprint author), US Ctr Dis Control & Prevent, Nairobi, Kenya. EM JAhmed@ke.cdc.gov FU US Centers for Disease Control and Prevention; International Rescue Committee; Kenya Medical Research Institute FX Support for this activity was provided through cooperative agreements among the US Centers for Disease Control and Prevention, the International Rescue Committee, and the Kenya Medical Research Institute. This manuscript is published with permission of the director of the Kenya Medical Research Institute. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention or other institutions with which the authors are affiliated. NR 48 TC 24 Z9 24 U1 0 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD JAN 17 PY 2012 VL 12 AR 7 DI 10.1186/1471-2334-12-7 PG 8 WC Infectious Diseases SC Infectious Diseases GA 902SK UT WOS:000301060100001 PM 22251705 ER PT J AU Duderstadt, SK Rose, CE Real, TM Sabatier, JF Stewart, B Ma, GH Yerubandi, UD Eick, AA Tokars, JI McNeil, MM AF Duderstadt, Susan K. Rose, Charles E., Jr. Real, Theresa M. Sabatier, Jennifer F. Stewart, Brock Ma, Guihua Yerubandi, Uma D. Eick, Angelia A. Tokars, Jerome I. McNeil, Michael M. TI Vaccination and risk of type 1 diabetes mellitus in active component US Military, 2002-2008 SO VACCINE LA English DT Article DE Type 1 diabetes mellitus; Adult vaccination; Vaccine safety ID MEDICAL SURVEILLANCE SYSTEM; VITAMIN-D STATUS; YOUNG-ADULTS; CHILDHOOD; CHILDREN; IMMUNIZATION; PREVALENCE; EPIDEMIOLOGY; ASSOCIATION; INFECTIONS AB Aims/hypothesis: To evaluate whether vaccination increases the risk of type 1 diabetes mellitus in active component U.S. military personnel. Methods: We conducted a retrospective cohort study among active component U.S. military personnel age 17-35 years. Individuals with first time diagnoses of type 1 diabetes between January 1, 2002 and December 31, 2008 were identified using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes. We used Poisson regression to estimate risk ratios between individual vaccine exposures and type 1 diabetes. Secondary analyses were performed controlling for receipt of multiple vaccines and available demographic variables. Results: Our study population consisted of 2,385,102 individuals followed for approximately 7,644,098 person-years of service. This included 1074 incident type 1 diabetes cases. We observed no significant increased risk of type 1 diabetes after vaccination with anthrax vaccine adsorbed (AVA) [RR = 1.00; 95% CI (0.85, 1.17)], smallpox vaccine [RR= 0.84; 95% (CI 0.70, 1.01)], typhoid vaccine [RR= 1.03; 95% CI (0.87, 1.22)], hepatitis B vaccine [RR= 0.83; 95% CI (0.72, 0.95)], measles mumps rubella vaccine (MMR) [RR= 0.71.95% CI (0.61, 0.83)], or yellow fever vaccine [RR = 0.70; 95% CI (0.59, 0.82)]. Conclusions: We did not find an increased risk of diagnosed type 1 diabetes and any of the study vaccines. We recommend that follow-up studies using medical record review to confirm case status should be considered to corroborate these findings. Published by Elsevier Ltd. C1 [Sabatier, Jennifer F.] Ctr Dis Control & Prevent, Ctr Global Hlth, Div Global HIV AIDS, Atlanta, GA USA. [Stewart, Brock] Sci Applicat Int Corp, Mclean, VA 22102 USA. [Eick, Angelia A.] USA, Ctr Hlth Promot & Prevent Med, Armed Forces Hlth Surveillance Ctr, Silver Spring, MD 20904 USA. RP McNeil, MM (reprint author), CDC, 1600 Clifton Rd NE,MS D-26, Atlanta, GA 30333 USA. EM mmm2@cdc.gov NR 50 TC 7 Z9 7 U1 2 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JAN 17 PY 2012 VL 30 IS 4 BP 813 EP 819 DI 10.1016/j.vaccine.2011.10.087 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 892CG UT WOS:000300263700016 PM 22075092 ER PT J AU Phinney, KW Bedner, M Tai, SSC Vamathevan, VV Sander, LC Sharpless, KE Wise, SA Yen, JH Schleicher, RL Chaudhary-Webb, M Pfeiffer, CM Betz, JM Coates, PM Picciano, MF AF Phinney, Karen W. Bedner, Mary Tai, Susan S. -C. Vamathevan, Veronica V. Sander, Lane C. Sharpless, Katherine E. Wise, Stephen A. Yen, James H. Schleicher, Rosemary L. Chaudhary-Webb, Madhulika Pfeiffer, Christine M. Betz, Joseph M. Coates, Paul M. Picciano, Mary Frances TI Development and Certification of a Standard Reference Material for Vitamin D Metabolites in Human Serum SO ANALYTICAL CHEMISTRY LA English DT Article ID TANDEM MASS-SPECTROMETRY; 25-HYDROXYVITAMIN D-3; CIRCULATING 25-HYDROXYVITAMIN-D; CANCER-RISK; ASSAYS; PREVENTION; ACCURACY AB The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health's Office of Dietary Supplements (NIH-ODS), has developed a Standard Reference Material (SRM) for the determination of 25-hydroxyvitamin D [25(OH)D] in serum. SRM 972 Vitamin D in Human Serum consists of four serum pools with different levels of vitamin D metabolites and has certified and reference values for 25 (OH)D-2, 25(OH)D-3, and 3-epi-25(OH)D-3. Value assignment of this SRM was accomplished using a combination of three isotope-dilution mass spectrometry approaches, with measurements performed at NIST and at the Centers for Disease Control and Prevention (CDC). Chromatographic resolution of the 3-epimer of 25(OH)D-3 proved to be essential for accurate determination of the metabolites. C1 [Phinney, Karen W.; Bedner, Mary; Tai, Susan S. -C.; Vamathevan, Veronica V.; Sander, Lane C.; Sharpless, Katherine E.; Wise, Stephen A.] Natl Inst Stand & Technol, Div Analyt Chem, Gaithersburg, MD 20899 USA. [Yen, James H.] Natl Inst Stand & Technol, Stat Engn Div, Gaithersburg, MD 20899 USA. [Schleicher, Rosemary L.; Chaudhary-Webb, Madhulika; Pfeiffer, Christine M.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Betz, Joseph M.; Coates, Paul M.; Picciano, Mary Frances] NIH, Off Dietary Supplements, Bethesda, MD 20892 USA. RP Phinney, KW (reprint author), Natl Inst Stand & Technol, Div Analyt Chem, Gaithersburg, MD 20899 USA. EM karen.phinney@nist.gov OI Sharpless, Katherine/0000-0001-6569-198X FU National Institutes of Health, Office of Dietary Supplements FX The authors wish to thank Graham Carter and Donald Wiebe for helpful discussions during the development of SRM 972. Partial funding for this work was provided by the National Institutes of Health, Office of Dietary Supplements. NR 31 TC 57 Z9 58 U1 0 U2 15 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD JAN 17 PY 2012 VL 84 IS 2 BP 956 EP 962 DI 10.1021/ac202047n PG 7 WC Chemistry, Analytical SC Chemistry GA 876UY UT WOS:000299134400034 PM 22141317 ER PT J AU Watkins, DJ McClean, MD Fraser, AJ Weinberg, J Stapleton, HM Sjodin, A Webster, TF AF Watkins, Deborah J. McClean, Michael D. Fraser, Alicia J. Weinberg, Janice Stapleton, Heather M. Sjoedin, Andreas Webster, Thomas F. TI Impact of Dust from Multiple Microenvironments and Diet on PentaBDE Body Burden SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID POLYBROMINATED DIPHENYL ETHERS; BROMINATED FLAME RETARDANTS; IN-HOUSE DUST; HUMAN EXPOSURE; UNITED-STATES; BREAST-MILK; HUMAN SERUM; INDOOR AIR; PBDES; HORMONE AB Our objectives were to determine relative contributions of diet and dust exposure from multiple microenvironments to PentaBDE body burden, and to explore the roe of handwipes as a measure of personal exposure to PentaBDE. We administered a food frequency questionnaire and collected serum, dust (office, main living area, bedroom, and vehicle), and handwipe samples from 31 participants. Sigma PentaBDEs (sum of BDE 28/33, 47, 99, 100, and 153) in handwipes collected in the office environment were weakly correlated with dust collected from offices (r = 0.35, p = 0.06) and bedrooms (r = 0.39, p = 0.04), but not with dust from main living areas (r = 0.05, p = 0.77) or vehicles (r = 0.17, p = 0.47). Sigma PentaBDEs in serum were correlated with dust from main living areas (r = 0.42, p = 0.02) and bedrooms (r = 0.49, p = 0.008), but not with dust from offices (r = 0.22, p = 0.25) or vehicles (r = 0.20, p = 0.41). Our final regression model included variables for main living area dust and handwipes, and predicted 55% of the variation in serum Sigma PentaBDE concentrations (p = 0.0004). Diet variables were not significant predictors of Sigma PentaBDEs in serum. Our research suggests that exposure to dust in the home environment may be the most important factor in predicting PentaBDE body burden in North Americans, and potential exposure pathways may involve PBDE residues on hands. C1 [Watkins, Deborah J.] Brown Univ, Ctr Environm Hlth & Technol, Providence, RI 02912 USA. [McClean, Michael D.; Webster, Thomas F.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. [Fraser, Alicia J.] Harvard Univ, Sch Med, Channing Lab, Boston, MA 02115 USA. [Weinberg, Janice] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA. [Stapleton, Heather M.] Duke Univ, Nicholas Sch Environm, Durham, NC 27708 USA. [Sjoedin, Andreas] Ctr Dis Control & Prevent CDC, NCEH, DLS, Atlanta, GA USA. RP Watkins, DJ (reprint author), Brown Univ, Ctr Environm Hlth & Technol, Providence, RI 02912 USA. EM Deborah_Watkins@brown.edu RI Sjodin, Andreas/F-2464-2010; McClean, Michael/J-2934-2015; OI McClean, Michael/0000-0002-3902-8823 FU National Institute of Environmental Health Sciences [R01ES015829, T32ES014562] FX We thank the study participants, Stephanie Chan, Dr. Jessica Nelson, Heather Simpson, Jennifer Valerio, and Courtney Walker. This work was supported by R01ES015829 and T32ES014562 from the National Institute of Environmental Health Sciences. NR 36 TC 36 Z9 37 U1 3 U2 45 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JAN 17 PY 2012 VL 46 IS 2 BP 1192 EP 1200 DI 10.1021/es203314e PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 876VQ UT WOS:000299136200080 PM 22142368 ER PT J AU Fraser, AJ Webster, TF Watkins, DJ Nelson, JW Stapleton, HM Calafat, AM Kato, K Shoeib, M Vieira, VM McClean, MD AF Fraser, Alicia J. Webster, Thomas F. Watkins, Deborah J. Nelson, Jessica W. Stapleton, Heather M. Calafat, Antonia M. Kato, Kayoko Shoeib, Mahiba Vieira, Veronica M. McClean, Michael D. TI Polyfluorinated Compounds in Serum Linked to Indoor Air in Office Environments SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID PERFLUOROOCTANE SULFONATE PFOS; PERFLUORINATED CHEMICALS; FLUOROTELOMER ALCOHOL; CONSUMER EXPOSURE; ACIDS; PERFLUOROCARBOXYLATES; BLOOD; BIRTH AB We aimed to investigate the role of indoor office air on exposure to polyfluorinated compounds (PFCs) among office workers. Week-long, active air sampling was conducted during the winter of 2009 in 31 offices in Boston, MA. Air samples were analyzed for fluorotelomer alcohols (FTOHs), sulfonamides (FOSAs), and sulfonamidoethanols (FOSEs). Serum was collected from each participant (n = 31) and analyzed for 12 PFCs including PFOA and PFOS. In air, FTOHs were present in the highest concentrations, particularly 8:2-FTOH (GM = 9920 pg/m(3)). FTOHs varied significantly by building with the highest levels observed in a newly constructed building. PFOA in serum was significantly correlated with air levels of 6:2-FTOH (r = 0.43), 8:2-FTOH (r = 0.60), and 10:2-FTOH (r = 0.62). Collectively, FTOHs in air significantly predicted PFOA in serum (p < 0.001) and explained approximately 36% of the variation in serum PFOA concentrations. PFOS in serum was not associated with air levels of FOSAs/FOSEs. In conclusion, FTOH concentrations in office air significantly predict serum PFOA concentrations in office workers. Variation in PFC air concentrations by building is likely due to differences in the number, type, and age of potential sources such as carpeting, furniture, and/or paint. C1 [Fraser, Alicia J.; Webster, Thomas F.; Watkins, Deborah J.; Nelson, Jessica W.; Vieira, Veronica M.; McClean, Michael D.] Boston Univ, Sch Publ Hlth, Boston, MA 02118 USA. [Stapleton, Heather M.] Duke Univ, Nicholas Sch Environm, Durham, NC 27708 USA. [Calafat, Antonia M.; Kato, Kayoko] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Shoeib, Mahiba] Environm Canada, Sci & Technol Branch, Toronto, ON M3H 5T4, Canada. RP McClean, MD (reprint author), Boston Univ, Sch Publ Hlth, 715 Albany St,T4W, Boston, MA 02118 USA. EM mmcclean@bu.edu RI McClean, Michael/J-2934-2015; Osborne, Nicholas/N-4915-2015; OI Osborne, Nicholas/0000-0002-6700-2284; McClean, Michael/0000-0002-3902-8823 FU National Institute of Environmental Health Sciences (NIEHS) [R01ES015829, T32ES014562] FX We thank Amal Wanigatunga, Brian Basden, and Tao Jia for technical assistance with analysis of the serum samples; Stephanie Chan, Heather Simpson, and Courtney Walker for help with sample collection; and all study participants for enabling this research. This research was supported in part by Grants R01ES015829 and T32ES014562 from the National Institute of Environmental Health Sciences (NIEHS). The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention, the NIEHS, or the National Institutes of Health. NR 30 TC 27 Z9 31 U1 10 U2 65 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JAN 17 PY 2012 VL 46 IS 2 BP 1209 EP 1215 DI 10.1021/es2038257 PG 7 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 876VQ UT WOS:000299136200082 PM 22148395 ER PT J AU Zhou, XL Ye, XY Calafat, AM AF Zhou, Xiaoliu Ye, Xiaoyun Calafat, Antonia M. TI Automated on-line column-switching HPLC-MS/MS method for the quantification of triclocarban and its oxidative metabolites in human urine and serum SO JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES LA English DT Article DE Triclocarban; Oxidative metabolite; HPLC-MS/MS; Urine; Serum ID TANDEM MASS-SPECTROMETRY; PERFORMANCE LIQUID-CHROMATOGRAPHY; MEASURING ENVIRONMENTAL PHENOLS; PERSONAL CARE PRODUCTS; IN-VITRO; TRICLOSAN; WATER; 3,4,4'-TRICHLOROCARBANILIDE; CHEMICALS; BIOTRANSFORMATION AB 3,4,4'-Trichlorocarbanilide (triclocarban, TCC) is widely used as an antimicrobial agent in a variety of consumer and personal care products. Because of its widespread use, the potential for human exposure to TCC is high. Human exposure to TCC may be assessed by measuring the concentrations of conjugated or free species of TCC and its two oxidative metabolites, 2'-hydroxy-TCC (2'-OH-TCC) and 3'-hydroxy-TCC (3'-OH-TCC), in urine or serum. To assess human exposure to TCC, we developed a method that uses restricted access materials (RAM) on-line solid phase extraction (SPE) coupled to high performance liquid chromatography-isotope dilution tandem mass spectrometry with peak focusing (HPLC-MS/MS). Sample clean-up by RAM relies on both size exclusion chromatography, to remove the high-molecular matrix components, and reversed phase partition, to extract and pre-concentrate the target analytes. TCC, 2'-OH-TCC and 3'-OH-TCC present in urine or serum were concentrated on the RAM SPE column, back-eluted from the SPE column, diluted through a mixing tee for peak focusing, separated by HPLC, and detected by isotope dilution-MS/MS. The method required a small amount of sample (50 mu L) and minimal sample pretreatment. The limits of detection (LOD) ranged from 0.01 to 0.1 ng/mL The method was applied to measure TCC and its metabolites in 158 urine and 16 serum samples collected from adults with no known exposure to TCC. TCC was detected in 35.4% of the urine samples (range: = 40 years old rated UEQ-5D significantly lower than younger persons. Higher UEQ-5D was significantly associated with higher monthly household income in a dose response fashion. The median UEQ-5D was highest among patients who had been successfully treated for TB and lowest among multi-drug resistant TB (MDR-TB) patients who were on treatment. Conclusions: U-CAL of patients with two co-morbidities overestimated the measured utilities, warranting further research of how best to estimate utilities of patients with such conditions. TB and MDR-TB treatments impacted on patients' self perceived health status. This effect diminished after successful treatment. C1 [Kittikraisak, Wanitchaya; Whitehead, Sara J.] US Ctr Dis Control & Prevent Collaborat, Thailand Minist Publ Hlth, Nonthaburi, Thailand. [Kingkaew, Pritaporn; Teerawattananon, Yot; Yothasamut, Jomkwan] Minist Publ Hlth, Hlth Intervent & Technol Assessment Program, Nonthaburi, Thailand. [Natesuwan, Supalert] Chiang Rai Reg Hosp, Chiang Rai, Thailand. [Manosuthi, Weerawat] Bamrasnaradura Infect Dis Inst, Nonthaburi, Thailand. [Chongsuvivatwong, Virasakdi] Prince Songkla Univ, Epidemiol Unit, Hat Yai, Thailand. [Whitehead, Sara J.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Kittikraisak, W (reprint author), US Ctr Dis Control & Prevent Collaborat, Thailand Minist Publ Hlth, Nonthaburi, Thailand. EM wanitchayak@th.cdc.gov FU United States Agency for International Development FX The authors gratefully acknowledge the United States Agency for International Development for funding this study. The funding agency had no role in study design, conduct, data analysis, or manuscript preparation. NR 50 TC 9 Z9 10 U1 1 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 11 PY 2012 VL 7 IS 1 AR e29775 DI 10.1371/journal.pone.0029775 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 906ON UT WOS:000301355700049 PM 22253777 ER PT J AU Dorell, CG Stokley, S Yankey, D Markowitz, LE AF Dorell, Christina G. Stokley, Shannon Yankey, David Markowitz, Lauri E. TI Compliance with recommended dosing intervals for HPV vaccination among females, 13-17 years, National Immunization Survey-Teen, 2008-2009 SO VACCINE LA English DT Article DE Immunization; Human papillomavirus vaccines; Adolescents; Females; Patient compliance; Cancer vaccines ID HUMAN-PAPILLOMAVIRUS VACCINE; HEALTH-INSURANCE; ADOLESCENTS; COVERAGE AB Data from the 2008 and 2009 National Immunization Survey-Teen were analyzed to determine age at initiation of the human papillomavirus vaccine (HPV) series among females 13-17 years (n = 7594) and assess compliance with the recommended HPV dosing intervals. Among females who initiated the HPV series, 56.7% of females <13 years at the time of the HPV vaccine recommendation publication did so by age 13; while the majority of females 13-14 and 15-17 years at the time of the recommendation publication did so at ages 14 (44.4%) and 16 (46.7%), respectively. Forty-six percent of females who received three doses completed the vaccination series in a period longer than the recommended time interval. Series completion at an earlier age to ensure protection before sexual debut is optimal. Improved provider communication of the need for three doses for long-term protection and implementing clinical practice guidelines to use reminder-recall systems may increase HPV completion. Published by Elsevier Ltd. C1 [Dorell, Christina G.; Stokley, Shannon; Yankey, David] Ctr Dis Control & Prevent, Immunizat Serv Div, Atlanta, GA 30333 USA. [Markowitz, Lauri E.] Ctr Dis Control & Prevent, Div Sexually Transmitted Dis Prevent, Atlanta, GA 30333 USA. RP Dorell, CG (reprint author), Ctr Dis Control & Prevent, Immunizat Serv Div, 1600 Clifton Rd,MS A-19, Atlanta, GA 30333 USA. EM cdorell@cdc.gov NR 15 TC 14 Z9 14 U1 1 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JAN 11 PY 2012 VL 30 IS 3 BP 503 EP 505 DI 10.1016/j.vaccine.2011.11.042 PG 3 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 912PO UT WOS:000301812300002 PM 22119587 ER PT J AU von Gottberg, A Cohen, C Whitelaw, A Chhagan, M Flannery, B Cohen, AL de Gouveia, L du Plessis, M Madhi, SA Klugman, KP AF von Gottberg, Anne Cohen, Cheryl Whitelaw, Andrew Chhagan, Meera Flannery, Brendan Cohen, Adam L. de Gouveia, Linda du Plessis, Mignon Madhi, Shabir A. Klugman, Keith P. CA Grp Enteric Resp Meningeal Dis TI Invasive disease due to Haemophilus influenzae serotype b ten years after routine vaccination, South Africa, 2003-2009 SO VACCINE LA English DT Article DE Haemophilus influenzae serotype b; Hib; Vaccine; Laboratory-based surveillance; Bacterial meningitis ID HIB CONJUGATE VACCINE; STREPTOCOCCUS-PNEUMONIAE; NEISSERIA-MENINGITIDIS; CHANGING EPIDEMIOLOGY; PNEUMOCOCCAL VACCINE; IMMUNIZATION; REPLACEMENT; CHILDREN; ELIMINATION; INFECTIONS AB Introduction: South Africa started routine infant immunization against Haemophilus influenzae serotype b (Hib) disease in 1999 with an accelerated three-dose schedule of Hib conjugate vaccine (HibCV) without a booster dose. Following initial declines in Hib disease, national surveillance has identified increasing numbers of Hib disease episodes in fully vaccinated children. Materials and methods: We reviewed national laboratory-based surveillance data from 2003 through 2009 for invasive Hib disease episodes among children <5 years, including HIV status and vaccination histories. We defined HibCV failures as invasive Hib disease in children at least four months of age who had received all recommended doses of HibCV. Results: Despite high HibCV vaccination coverage, detection rates of Hib disease in children <5 years increased from 0.7 per 100,000 population in 2003 to 1.3/100,000 in 2009 (p < 0.001). Among 263 episodes of invasive Hib disease among children with known vaccination status, 135 (51%) were classified as vaccine failures. Of vaccine failures, 55% occurred among case patients >= 18 months old. HIV status was documented for 90 children with vaccine failure; 53% were not HIV infected. Discussion and conclusions: Vaccine failures, which occurred in both HIV-infected and -uninfected children, comprised half of the rise in invasive Hib disease detected in South African children 10 years after national introduction of Hib vaccine. These findings suggest that HibCV recommendations may require revision. In November 2010, children in South Africa began receiving a booster dose of HibCV as part of a pentavalent vaccine. (C) 2011 Elsevier Ltd. All rights reserved. C1 [von Gottberg, Anne; Cohen, Cheryl; de Gouveia, Linda; du Plessis, Mignon; Madhi, Shabir A.; Klugman, Keith P.] NICD, NHLS, Johannesburg, South Africa. [von Gottberg, Anne; de Gouveia, Linda; du Plessis, Mignon; Klugman, Keith P.] Univ Witwatersrand, Fac Hlth Sci, Sch Pathol, Johannesburg, South Africa. [von Gottberg, Anne; de Gouveia, Linda; du Plessis, Mignon; Madhi, Shabir A.; Klugman, Keith P.] MRC, Resp & Meningeal Pathogens Res Unit, Johannesburg, South Africa. [Cohen, Cheryl] Univ Witwatersrand, Fac Hlth Sci, Sch Publ Hlth, Johannesburg, South Africa. [Whitelaw, Andrew] Univ Cape Town, Dept Clin & Lab Sci, ZA-7925 Cape Town, South Africa. [Chhagan, Meera] Pietermaritzburg Metropolitan Hosp Complex, Dept Paediat & Child Hlth, Pietermaritzburg, South Africa. [Chhagan, Meera] Univ KwaZulu Natal, Pietermaritzburg, South Africa. [Flannery, Brendan; Cohen, Adam L.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Madhi, Shabir A.] Univ Witwatersrand, Dept Sci & Technol, Natl Res Fdn Vaccine Preventable Dis, Johannesburg, South Africa. [Klugman, Keith P.] Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA 30322 USA. [Klugman, Keith P.] Emory Univ, Sch Med, Div Infect Dis, Atlanta, GA USA. RP von Gottberg, A (reprint author), NICD, Resp & Meningeal Pathogens Res Unit, Private Bag X4, ZA-2131 Johannesburg, Gauteng, South Africa. EM annev@nicd.ac.za OI de Gouveia, Linda/0000-0002-1418-8468 FU NICD/NHLS; United States Agency for International Development's Antimicrobial Resistance Initiative; Centers for Disease Control and Prevention (CDC), Atlanta, Georgia [U60/CCU022088]; CDC [U62/CCU022901]; GlaxoSmithKline; Pfizer; sanofi-aventis; MERCK; Novartis FX This study received funding from the NICD/NHLS and was supported in part by funds from the United States Agency for International Development's Antimicrobial Resistance Initiative, transferred via a cooperative agreement (number U60/CCU022088) from the Centers for Disease Control and Prevention (CDC), Atlanta, Georgia; and cooperative agreement U62/CCU022901 from the CDC. (The contents are solely the responsibility of the authors and do not necessarily represent the official views of the CDC.); AvG has received grant funding from GlaxoSmithKline, Pfizer and sanofi-aventis. SAM has participated in speakers' bureau and received grant funds from GlaxoSmithKline, MERCK, Pfizer and sanofi-aventis. KPK has received funding from Pfizer and consultancy fees from Pfizer, GlaxoSmithKline, Novartis and sanofi-aventis. NR 49 TC 17 Z9 18 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JAN 11 PY 2012 VL 30 IS 3 BP 565 EP 571 DI 10.1016/j.vaccine.2011.11.066 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 912PO UT WOS:000301812300010 PM 22119925 ER PT J AU Kim, SA Grimm, KA Harris, DM Scanlon, KS Demissie, Z AF Kim, Sonia A. Grimm, Kirsten A. Harris, Diane M. Scanlon, Kelley S. Demissie, Zewditu TI Fruit and Vegetable Consumption Among High School Students-United States, 2010 (Reprinted from MMWR, vol 60, pg 1583-1586, 2011) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint ID FOOD C1 [Demissie, Zewditu] CDC, Atlanta, GA 30333 USA. EM skim3@cdc.gov NR 11 TC 0 Z9 0 U1 1 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JAN 11 PY 2012 VL 307 IS 2 BP 135 EP 137 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 875NP UT WOS:000299038300008 ER PT J AU Harpaz, R Hales, CM Bialek, SR AF Harpaz, Rafael Hales, Craig M. Bialek, Stephanie R. CA ACIP Zoster Working Grp TI Update on Herpes Zoster Vaccine: Licensure for Persons Aged 50 Through 59 Years (Reprinted from MMWR, vol 60, pg 1528, 2011) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Harpaz, Rafael; Hales, Craig M.; Bialek, Stephanie R.] CDC, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Atlanta, GA 30333 USA. RP Harpaz, R (reprint author), CDC, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Atlanta, GA 30333 USA. EM rharpaz@cdc.gov NR 7 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JAN 11 PY 2012 VL 307 IS 2 BP 137 EP 138 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 875NP UT WOS:000299038300009 ER PT J AU Holmberg, JA Basavaraju, S Reed, C Drammeh, B Qualls, M AF Holmberg, Jerry A. Basavaraju, Sridhar Reed, Christie Drammeh, Bakary Qualls, Michael TI Progress Toward Strengthening National Blood Transfusion Services-14 Countries, 2008-2010 (Reprinted from MMWR, vol 60, pg 1577-1582, 2011) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint ID KENYA; RISK; HIV C1 [Basavaraju, Sridhar; Reed, Christie; Drammeh, Bakary; Qualls, Michael] CDC, Div Global HIV AIDS, Ctr Global Hlth, Atlanta, GA 30333 USA. RP Basavaraju, S (reprint author), CDC, Div Global HIV AIDS, Ctr Global Hlth, Atlanta, GA 30333 USA. EM sbasavaraju@cdc.gov NR 11 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JAN 11 PY 2012 VL 307 IS 2 BP 138 EP 141 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 875NP UT WOS:000299038300010 ER PT J AU Wu, XC Lund, MJ Kimmick, GG Richardson, LC Sabatino, SA Chen, VW Fleming, ST Morris, CR Huang, B Trentham-Dietz, A Lipscomb, J AF Wu, Xiao-Cheng Lund, Mary Jo Kimmick, Gretchen G. Richardson, Lisa C. Sabatino, Susan A. Chen, Vivien W. Fleming, Steven T. Morris, Cyllene R. Huang, Bin Trentham-Dietz, Amy Lipscomb, Joseph TI Influence of Race, Insurance, Socioeconomic Status, and Hospital Type on Receipt of Guideline-Concordant Adjuvant Systemic Therapy for Locoregional Breast Cancers SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID QUALITY-OF-CARE; CHEMOTHERAPY; WOMEN; HEALTH; RACE/ETHNICITY; DISPARITIES; INFORMATION; SURVIVORS; AMERICAN; NATION AB Purpose For breast cancer, guidelines direct the delivery of adjuvant systemic therapy on the basis of lymph node status, histology, tumor size, grade, and hormonal receptor status. We explored how race/ethnicity, insurance, census tract-level poverty and education, and hospital Commission on Cancer (CoC) status were associated with the receipt of guideline-concordant adjuvant systemic therapy. Methods Locoregional breast cancers diagnosed in 2004 (n = 6,734) were from the National Program of Cancer Registries-funded seven-state Patterns of Care study of the Centers for Disease Control and Prevention. Predictors of guideline-concordant (receiving/not receiving) adjuvant systemic therapy, according to National Comprehensive Cancer Network Guidelines, were explored by logistic regression. Results Overall, 35% of women received nonguideline chemotherapy, 12% received nonguideline regimens, and 20% received nonguideline hormonal therapy. Significant predictors of nonguideline chemotherapy included Medicaid insurance (odds ratio [OR], 0.66; 95% CI, 0.50 to 0.86), high-poverty areas (OR, 0.77; 95% CI, 0.62 to 0.96), and treatment at non-CoC hospitals (OR, 0.69; 95% CI, 0.56 to 0.85), with adjustment for age, registry, and clinical variables. Predictors of nonguideline regimens among chemotherapy recipients included lack of insurance (OR, 0.47; 95% CI, 0.25 to 0.92), high-poverty areas (OR, 0.71; 95% CI, 0.51 to 0.97), and low-education areas (OR, 0.65; 95% CI, 0.48 to 0.89) after adjustment. Living in high-poverty areas (OR, 0.78; 95% CI, 0.64 to 0.96) and treatment at non-CoC hospitals (OR, 0.68; 95% CI, 0.55 to 0.83) predicted nonguideline hormonal therapy after adjustment. ORs for poverty, education, and insurance were attenuated in the full models. Conclusion Sociodemographic and hospital factors are associated with guideline-concordant use of systemic therapy for breast cancer. The identification of modifiable factors that lead to nonguideline treatment may reduce disparities in breast cancer survival. J Clin Oncol 30:142-150. (C) 2011 by American Society of Clinical Oncology C1 [Wu, Xiao-Cheng; Chen, Vivien W.] Louisiana State Univ, Hlth Sci Ctr, New Orleans, LA 70112 USA. [Lund, Mary Jo; Lipscomb, Joseph] Emory Univ, Atlanta, GA 30322 USA. [Richardson, Lisa C.; Sabatino, Susan A.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Kimmick, Gretchen G.] Duke Univ, Med Ctr, Durham, NC USA. [Fleming, Steven T.] Univ Kentucky, Coll Publ Hlth, Lexington, KY 40506 USA. [Morris, Cyllene R.] Inst Publ Hlth, Sacramento, CA USA. [Trentham-Dietz, Amy] Univ Wisconsin, Madison, WI USA. RP Wu, XC (reprint author), Louisiana State Univ, Hlth Sci Ctr, 1615 Poydras St,Suite 1400, New Orleans, LA 70112 USA. EM xwu@lsuhsc.edu NR 38 TC 59 Z9 60 U1 2 U2 6 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD JAN 10 PY 2012 VL 30 IS 2 BP 142 EP 150 DI 10.1200/JCO.2011.36.8399 PG 9 WC Oncology SC Oncology GA 923KU UT WOS:000302619000014 PM 22147735 ER PT J AU Smith, KM Anthony, SJ Switzer, WM Epstein, JH Seimon, T Jia, HW Sanchez, MD Huynh, TT Galland, GG Shapiro, SE Sleeman, JM McAloose, D Stuchin, M Amato, G Kolokotronie, SO Lipkin, WI Karesh, WB Daszak, P Marano, N AF Smith, Kristine M. Anthony, Simon J. Switzer, William M. Epstein, Jonathan H. Seimon, Tracie Jia, Hongwei Sanchez, Maria D. Huynh, Thanh Thao Galland, G. Gale Shapiro, Sheryl E. Sleeman, Jonathan M. McAloose, Denise Stuchin, Margot Amato, George Kolokotronie, Sergios-Orestis Lipkin, W. Ian Karesh, William B. Daszak, Peter Marano, Nina TI Zoonotic Viruses Associated with Illegally Imported Wildlife Products SO PLOS ONE LA English DT Article ID OXIDASE-SUBUNIT-I; FOAMY VIRUS; DNA; INFECTION; PCR; IDENTIFICATION; PRIMATES; TYPE-1; GENE; AIDS AB The global trade in wildlife has historically contributed to the emergence and spread of infectious diseases. The United States is the world's largest importer of wildlife and wildlife Products, yet minimal Pathogen surveillance has Precluded assessment of the health risks posed by this practice This report details the findings of a pilot project to establish surveillance methodology for zoonotic agents in confiscated wildlife products. Initial findings from samples collected at several international airports identified Parts originating from nonhuman Primate (NHP) and rodent species, including baboon, chimpanzee, mangabey, guenon, green monkey, cane rat and rat. Pathogen screening identified retroviruses (simian foamy virus) and/or herpesviruses (cytomegalovirus and lymphocryptovirus) in the NHP samples. These results are first demonstration that illegal bushmeat importation into the United States could act as a conduit for pathogen spread, and suggest that implementation of disease surveillance of the wildlife trade will help facilitate Prevention of disease emergence. C1 [Smith, Kristine M.; Anthony, Simon J.; Epstein, Jonathan H.; Sanchez, Maria D.; Karesh, William B.; Daszak, Peter] EcoHealth Alliance, New York, NY USA. [Smith, Kristine M.; Seimon, Tracie; McAloose, Denise; Karesh, William B.] Wildlife Conservat Soc, Bronx, NY USA. [Switzer, William M.; Jia, Hongwei; Galland, G. Gale; Shapiro, Sheryl E.; Marano, Nina] Ctr Dis Control & Prevent, Atlanta, GA USA. [Anthony, Simon J.; Seimon, Tracie; Sanchez, Maria D.; Stuchin, Margot; Lipkin, W. Ian] Columbia Univ, New York, NY USA. [Huynh, Thanh Thao] Tufts Univ, Cummings Sch Vet Med, North Grafton, MA USA. [Sleeman, Jonathan M.] US Geol Survey, Natl Wildlife Hlth Ctr, Madison, WI USA. [Stuchin, Margot; Amato, George; Kolokotronie, Sergios-Orestis] Amer Museum Nat Hist, Sackler Inst Comparat Genom, New York, NY 10024 USA. RP Smith, KM (reprint author), EcoHealth Alliance, New York, NY USA. EM ksmith@ecohealthalliance.org RI Kolokotronis, Sergios-Orestis/A-1910-2009 OI Kolokotronis, Sergios-Orestis/0000-0003-3309-8465 FU V. Kann Rasmussen Foundation; Consortium for Conservation Medicine; New York Community Trust; Eppley Foundation for Research FX Funding for this study was supplied by the V. Kann Rasmussen Foundation, the Consortium for Conservation Medicine, the New York Community Trust, and the Eppley Foundation for Research. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 39 TC 41 Z9 43 U1 3 U2 77 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 10 PY 2012 VL 7 IS 1 BP 71 EP 79 AR e29505 DI 10.1371/journal.pone.0029505 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 906OA UT WOS:000301353900008 PM 22253731 ER PT J AU Fang, J Cogswell, ME Keenan, NL Merritt, RK AF Fang, Jing Cogswell, Mary E. Keenan, Nora L. Merritt, Robert K. TI Primary Health Care Providers' Attitudes and Counseling Behaviors Related to Dietary Sodium Reduction SO ARCHIVES OF INTERNAL MEDICINE LA English DT Letter ID BLOOD-PRESSURE; HYPERTENSION C1 [Fang, Jing; Cogswell, Mary E.; Keenan, Nora L.; Merritt, Robert K.] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Fang, J (reprint author), Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy NE,Mail Stop K-47, Atlanta, GA 30341 USA. EM jfang@cdc.gov FU Intramural CDC HHS [CC999999] NR 8 TC 3 Z9 3 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD JAN 9 PY 2012 VL 172 IS 1 BP 76 EP 78 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 874LM UT WOS:000298958900022 PM 22232154 ER PT J AU Hsiang, MS Hwang, J Kunene, S Drakeley, C Kandula, D Novotny, J Parizo, J Jensen, T Tong, M Kemere, J Dlamini, S Moonen, B Angov, E Dutta, S Ockenhouse, C Dorsey, G Greenhouse, B AF Hsiang, Michelle S. Hwang, Jimee Kunene, Simon Drakeley, Chris Kandula, Deepika Novotny, Joseph Parizo, Justin Jensen, Trevor Tong, Marcus Kemere, Jordan Dlamini, Sabelo Moonen, Bruno Angov, Evelina Dutta, Sheetij Ockenhouse, Christian Dorsey, Grant Greenhouse, Bryan TI Surveillance for Malaria Elimination in Swaziland: A National Cross-Sectional Study Using Pooled PCR and Serology SO PLOS ONE LA English DT Article ID DRIED BLOOD SPOTS; TRANSMISSION; FEASIBILITY; PLASMODIUM; COMMUNITY; MARKERS AB Background: To guide malaria elimination efforts in Swaziland and other countries, accurate assessments of transmission are critical. Pooled-PCR has potential to efficiently improve sensitivity to detect infections; serology may clarify temporal and spatial trends in exposure. Methodology/Principal Findings: Using a stratified two-stage cluster, cross-sectional design, subjects were recruited from the malaria endemic region of Swaziland. Blood was collected for rapid diagnostic testing (RDT), pooled PCR, and ELISA detecting antibodies to Plasmodium falciparum surface antigens. Of 4330 participants tested, three were RDT-positive yet false positives by PCR. Pooled PCR led to the identification of one P. falciparum and one P. malariae infection among RDT-negative participants. The P. falciparum-infected participant reported recent travel to Mozambique. Compared to performing individual testing on thousands of samples, PCR pooling reduced labor and consumable costs by 95.5%. Seropositivity was associated with age >= 20 years (11.7% vs 1.9%, P < 0.001), recent travel to Mozambique (OR 4.4 [95% CI 1.0-19.0]) and residence in southeast Swaziland (RR 3.78, P < 0.001). Conclusions: The prevalence of malaria infection and recent exposure in Swaziland are extremely low, suggesting elimination is feasible. Future efforts should address imported malaria and target remaining foci of transmission. Pooled PCR and ELISA are valuable surveillance tools for guiding elimination efforts. C1 [Hsiang, Michelle S.; Hwang, Jimee; Kandula, Deepika; Novotny, Joseph] Univ Calif San Francisco, Global Hlth Grp, San Francisco, CA 94143 USA. [Hsiang, Michelle S.] Univ Calif San Francisco, Dept Pediat, San Francisco, CA USA. [Hwang, Jimee] Ctr Dis Control & Prevent, Malaria Branch, Atlanta, GA USA. [Kunene, Simon; Dlamini, Sabelo] Dept Hlth, Malaria Control Program, Manzini, Swaziland. [Drakeley, Chris] London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1, England. [Kandula, Deepika; Novotny, Joseph; Moonen, Bruno] Clinton Hlth Access Initiat, Boston, MA USA. [Parizo, Justin; Jensen, Trevor] Univ Calif San Francisco, Sch Med, San Francisco, CA USA. [Tong, Marcus] Univ Calif Los Angeles, Sch Engn & Appl Sci, Los Angeles, CA 90024 USA. [Kemere, Jordan] Univ N Carolina, Chapel Hill, NC USA. [Angov, Evelina; Dutta, Sheetij; Ockenhouse, Christian] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. [Dorsey, Grant; Greenhouse, Bryan] Univ Calif San Francisco, Dept Med, San Francisco, CA USA. RP Hsiang, MS (reprint author), Univ Calif San Francisco, Global Hlth Grp, San Francisco, CA 94143 USA. EM HsiangM@peds.ucsf.edu OI Greenhouse, Bryan/0000-0003-0287-9111 FU Global Fund to Fight AIDS, Tuberculosis and Malaria; Southern Africa Roll Back Malaria Network through Swaziland Ministry of Health [A115545]; Pediatric Infectious Diseases Society [A112604]; Bill and Melinda Gates Foundation [A108197] FX Global Fund to Fight AIDS, Tuberculosis and Malaria and Southern Africa Roll Back Malaria Network through Swaziland Ministry of Health (grant A115545); Pediatric Infectious Diseases Society (grant A112604); and the Bill and Melinda Gates Foundation (grant A108197). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 33 TC 39 Z9 39 U1 0 U2 5 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 6 PY 2012 VL 7 IS 1 AR e29550 DI 10.1371/journal.pone.0029550 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 904IR UT WOS:000301188800020 PM 22238621 ER PT J AU Mochel, F Durant, B Meng, XL O'Callaghan, J Yu, H Brouillet, E Wheeler, VC Humbert, S Schiffmann, R Durr, A AF Mochel, Fanny Durant, Brandon Meng, Xingli O'Callaghan, James Yu, Hua Brouillet, Emmanuel Wheeler, Vanessa C. Humbert, Sandrine Schiffmann, Raphael Durr, Alexandra TI Early Alterations of Brain Cellular Energy Homeostasis in Huntington Disease Models SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID FOCUSED MICROWAVE IRRADIATION; CAG REPEAT INSTABILITY; KNOCK-IN MICE; CREATINE-KINASE; TRANSGENIC MICE; TRINUCLEOTIDE REPEAT; MUTANT HUNTINGTIN; CLINICAL SYMPTOMS; MOUSE-BRAIN; MITOCHONDRIAL AB Brain energy deficit has been a suggested cause of Huntington disease (HD), but ATP depletion has not reliably been shown in preclinical models, possibly because of the immediate post-mortem changes in cellular energy metabolism. To examine a potential role of a low energy state in HD, we measured, for the first time in a neurodegenerative model, brain levels of high energy phosphates using microwave fixation, which instantaneously inactivates brain enzymatic activities and preserves in vivo levels of analytes. We studied HD transgenic R6/2 mice at ages 4, 8, and 12 weeks. We found significantly increased creatine and phosphocreatine, present as early as 4 weeks for phosphocreatine, preceding motor system deficits and decreased ATP levels in striatum, hippocampus, and frontal cortex of R6/2 mice. ATP and phosphocreatine concentrations were inversely correlated with the number of CAG repeats. Conversely, in mice injected with 3-nitroproprionic acid, an acute model of brain energy deficit, both ATP and phosphocreatine were significantly reduced. Increased creatine and phosphocreatine in R6/2 mice was associated with decreased guanidinoacetate N-methyltransferase and creatine kinase, both at the protein and RNA levels, and increased phosphorylated AMP-dependent protein kinase (pAMPK) over AMPK ratio. In addition, in 4-month-old knock-in Hdh(Q111/+) mice, the earliest metabolic alterations consisted of increased phosphocreatine in the frontal cortex and increased the pAMPK/AMPK ratio. Altogether, this study provides the first direct evidence of chronic alteration in homeostasis of high energy phosphates in HD models in the earliest stages of the disease, indicating possible reduced utilization of the brain phosphocreatine pool. C1 [Mochel, Fanny] Hop La Pitie Salpetriere, Brain & Spine Inst, INSERM UMR S975, F-75013 Paris, France. [Mochel, Fanny; Durr, Alexandra] Hop La Pitie Salpetriere, AP HP, Dept Genet, F-75013 Paris, France. [Mochel, Fanny] Univ Paris 06, F-75005 Paris, France. [Mochel, Fanny; Durant, Brandon; Meng, Xingli] Baylor Res Inst, Inst Metab Dis, Dallas, TX 75226 USA. [O'Callaghan, James] NIOSH, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. [Yu, Hua; Humbert, Sandrine; Schiffmann, Raphael] INSERM U1005, Inst Curie, CNRS UMR3306, F-91405 Orsay, France. [Brouillet, Emmanuel] CEA, URA CEA CNRS 2210, Serv MIRCen, F-92265 Fontenay Aux Roses, France. [Wheeler, Vanessa C.] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA. RP Mochel, F (reprint author), Hop La Pitie Salpetriere, Brain & Spine Inst, INSERM UMR S975, F-75013 Paris, France. EM fanny.mochel@upmc.fr RI Brouillet, Emmanuel/B-4784-2014; Humbert, Sandrine/S-2981-2016; OI Brouillet, Emmanuel/0000-0001-6322-7403; Durant, Brandon/0000-0003-3028-6161 FU National Institutes of Health [NS32765, NS049206]; CHDI Foundation, Inc. FX This work was supported, in whole or in part, by National Institutes of Health Grants NS32765 and NS049206 (to V. C. W.). This work was also supported by the CHDI Foundation, Inc. NR 47 TC 51 Z9 52 U1 0 U2 2 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD JAN 6 PY 2012 VL 287 IS 2 BP 1361 EP 1370 DI 10.1074/jbc.M111.309849 PG 10 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 877IE UT WOS:000299170300050 PM 22123819 ER PT J AU Wood, JM Major, D Heath, A Newman, RW Hoschler, K Stephenson, I Clark, T Katz, JM Zambon, MC AF Wood, John M. Major, Diane Heath, Alan Newman, Robert W. Hoschler, Katja Stephenson, Iain Clark, Tristan Katz, Jacqueline M. Zambon, Maria C. TI Reproducibility of serology assays for pandemic influenza H1N1: Collaborative study to evaluate a candidate WHO International Standard SO VACCINE LA English DT Article DE Influenza; Serology; Haemagglutination-inhibition; Neutralisation; Antibody standard; Pandemic ID NEUTRALIZING ANTIBODY; INFECTION; VIRUS AB Haemagglutination-inhibition (HI) and virus neutralisation (VN) assays are used to evaluate immunogenicity of pandemic H1N1 vaccines; however these bioassays are poorly standardised leading to inter-laboratory variation. A candidate International Standard (IS) for antibody to H1N1pdm virus (09/194) was prepared from pooled sera of subjects who had either recovered from H1N1pdm infection or who had been immunised with an adjuvanted subunit vaccine prepared from reassortant virus NYMC X-179A (derived from A/California/7/2009 virus). Ten laboratories from seven countries tested the candidate IS, 09/194 and a panel of human sera by HI and VN using the A/California/7/2009 virus (six laboratories) and/or the reassortant virus NYMC X-179A (ten laboratories). As expected, the inter-laboratory variability for HI and VN assay results was high. For results of antibody tests to NYMC X-179A, the % geometric coefficient of variation (%GCV) for 09/194 between laboratories was 83% for HI and 192% for VN. For tests of all sera, the median %GCV ranged from 95 to 345% for HI (80-fold variation) and 204 to 383% for VN (109-fold variation), but for the titres relative to 09/194 the median %GCV was much reduced (HI 34-231%; VN 44-214%). For tests of antibody to the A/California/7/2009 wild type virus there were similar reductions in %GCV when 09/194 was used. These results suggest that 09/194 will be of use to standardise assays of antibody to A/California/7/2009 vaccine and 09/194 has now been established by WHO as an IS for antibody to A/California/7/2009 with an assigned potency of 1300 IU per ml. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Major, Diane] Hlth Protect Agcy, Natl Inst Biol Stand & Control, Div Virol, Potters Bar EN6 3QG, Herts, England. [Hoschler, Katja; Zambon, Maria C.] Hlth Protect Agcy, Ctr Infect, Colindale, England. [Stephenson, Iain; Clark, Tristan] Univ Leicester, Leicester, Leics, England. [Katz, Jacqueline M.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Major, D (reprint author), Hlth Protect Agcy, Natl Inst Biol Stand & Control, Div Virol, Blanche Lane, Potters Bar EN6 3QG, Herts, England. EM Diane.Major@nibsc.hpa.org.uk NR 21 TC 34 Z9 35 U1 1 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JAN 5 PY 2012 VL 30 IS 2 BP 210 EP 217 DI 10.1016/j.vaccine.2011.11.019 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 887YU UT WOS:000299971800017 PM 22100887 ER PT J AU Dong, LB Liu, F Fairman, J Hong, DK Lewis, DB Monath, T Warner, JF Belser, JA Patel, J Hancock, K Katz, JM Lu, XH AF Dong, Libo Liu, Feng Fairman, Jeffery Hong, David K. Lewis, David B. Monath, Thomas Warner, John F. Belser, Jessica A. Patel, Jenish Hancock, Kathy Katz, Jacqueline M. Lu, Xiuhua TI Cationic liposome-DNA complexes (CLDC) adjuvant enhances the immunogenicity and cross-protective efficacy of a pre-pandemic influenza A H5N1 vaccine in mice SO VACCINE LA English DT Article DE Influenza A H5N1 virus; Adjuvant; CLDC; Cross-clade protection; Dose-sparing; Antibody responses; CD4(+) T-cell immunity ID HEMAGGLUTININ-SPECIFIC ANTIBODIES; VIRUS-INFECTION; IMMUNE-RESPONSES; MF59-ADJUVANTED INFLUENZA; RANDOMIZED-TRIAL; T-LYMPHOCYTES; B-CELLS; SAFETY; ACTIVATION; RECOVERY AB The development of pre-pandemic influenza A H5N1 vaccines that confer both antigen-sparing and cross-clade protection are a high priority given the limited worldwide capacity for influenza vaccine production, and the antigenic and genetic heterogeneity of circulating H5N1 viruses. The inclusion of potent adjuvants in vaccine formulations may achieve both of these aims. Here we show that the addition of JVRS-100, an adjuvant consisting of cationic liposome-DNA complexes (CLDC) to a clade 1-derived H5N1 split vaccine induced significantly higher virus-specific antibody than unadjuvanted formulations, with a >30-fold dose-sparing effect and induction of increased antigen-specific CD4(+) T-cell responses in mice. All mice that received one dose of adjuvanted vaccine and subsequent H5N1 viral challenges exhibited mild illness, lower lung viral titers, undetectable spleen and brain viral titers, and 100% survival after either homologous clade 1 or heterologous clade 2 H5N1 viral challenges, whereas unadjuvanted vaccine recipients showed significantly increased weight loss, viral titers, and mortality. The protective immunity induced by JVRS-100 adjuvanted H5N1 vaccine was shown to last for over one year without significant waning. Thus, JVRS-100 adjuvanted H5N1 vaccine elicited enhanced humoral and T-cell responses, dose-sparing, and cross-clade protection in mice. CLDC holds promise as an adjuvant for human pre-pandemic inactivated H5N1 vaccines. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Dong, Libo; Liu, Feng; Belser, Jessica A.; Patel, Jenish; Hancock, Kathy; Katz, Jacqueline M.; Lu, Xiuhua] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Fairman, Jeffery] Colby Pharmaceut Co, Menlo Pk, CA USA. [Hong, David K.; Lewis, David B.] Stanford Univ, Dept Pediat, Interdept Program Immunol, Stanford, CA 94305 USA. [Hong, David K.; Lewis, David B.] Stanford Univ, Inst Immun Transplantat & Infect, Stanford, CA 94305 USA. [Monath, Thomas; Warner, John F.] Juvaris BioTherapeut Inc, Burlingame, CA USA. RP Lu, XH (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. EM XLu@cdc.gov OI Patel, Jenish/0000-0001-5310-8160 FU NIAID [1U01AI074512-1]; Centers for Diseases Control and Prevention FX We thank the national public health laboratories of Vietnam, Turkey, and China for providing the human influenza A H5N1 virus isolates. We thank Dr. Terry Tumpey for animal management support. This work was supported in part by NIAID grant 1U01AI074512-1 (to J. Fairman and D.B. Lewis). This work also was supported in part by an appointment to the Research Participation Program at the Centers for Diseases Control and Prevention administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and CDC (to F. Liu). NR 69 TC 14 Z9 15 U1 1 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JAN 5 PY 2012 VL 30 IS 2 BP 254 EP 264 DI 10.1016/j.vaccine.2011.10.103 PG 11 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 887YU UT WOS:000299971800023 PM 22085545 ER PT J AU Eklund, C Unger, ER Nardelli-Haefliger, D Zhou, TQ Dillner, J AF Eklund, Carina Unger, Elizabeth R. Nardelli-Haefliger, Denise Zhou, Tiequn Dillner, Joakim TI International collaborative proficiency study of Human Papillomavirus type 16 serology SO VACCINE LA English DT Article DE Human Papillomavirus; Serology; Proficiency ID STANDARDIZATION; VACCINE; ASSAYS; HPV16 AB We performed an international proficiency study of Human Papillomavirus (HPV) type 16 serology. A common methodology for serology based on virus-like particle (VLP) ELISA was used by 10 laboratories in 6 continents. The laboratories used the same VLP reference reagent, which was selected as the most stable, sensitive and specific VLP preparation out of VLPs donated from 5 different sources. A blinded proficiency panel consisting of 52 serum samples from women with PCR-verified HPV 16-infection, 11 control serum samples from virginal women and the WHO HPV 16 International Standard (IS) serum were distributed. The mean plus 3 standard deviations of the negative control serum samples was the most generally useful "cut-off" criterion for distinguishing positive and negative samples. Using sensitivity of at least 50% and a specificity of 100% as proficiency criteria, 6/10 laboratories were proficient. In conclusion, an international Standard Operating Procedure for HPV serology, an international reporting system in International Units (IU) and a common "cut-off" criterion have been evaluated in an international HPV serology proficiency study. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Eklund, Carina; Dillner, Joakim] Skane & Lund Univ, Lab Med, WHO HPV LabNet Global Reference Lab, Dept Clin, Malmo, Sweden. [Eklund, Carina; Dillner, Joakim] Skane & Lund Univ, Lab Med, WHO HPV LabNet Global Reference Lab, Dept Med Microbiol, Malmo, Sweden. [Eklund, Carina; Dillner, Joakim] Karolinska Inst, Dept Lab Med, Stockholm, Sweden. [Eklund, Carina; Dillner, Joakim] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. [Unger, Elizabeth R.] Ctr Dis Control & Prevent, WHO HPV LabNet Global Reference Lab, Atlanta, GA USA. [Nardelli-Haefliger, Denise] CHU Vaudois, Inst Microbiol, WHO HPV LabNet Europe Reg Reference Lab, CH-1011 Lausanne, Switzerland. [Nardelli-Haefliger, Denise] CHU Vaudois, Dept Urol, CH-1011 Lausanne, Switzerland. [Nardelli-Haefliger, Denise] Univ Lausanne, CH-1011 Lausanne, Switzerland. [Zhou, Tiequn] WHO, Qual Safety & Stand Team, Immunizat Vaccines & Biol Dept, CH-1211 Geneva, Switzerland. RP Dillner, J (reprint author), Karolinska Univ Hosp Huddinge, Dept Lab Med, F68, S-14186 Stockholm, Sweden. EM joakim.dillner@ki.se OI nardelli-haefliger, denise/0000-0003-1812-9905; Unger, Elizabeth/0000-0002-2925-5635 FU WHO; Bill and Melinda Gates Foundation FX This work was supported by the WHO via a project funded by the Bill and Melinda Gates Foundation. We are grateful to the companies and research groups that donated VLPs as candidate materials for use as reference reagents. NR 19 TC 10 Z9 10 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JAN 5 PY 2012 VL 30 IS 2 BP 294 EP 299 DI 10.1016/j.vaccine.2011.10.096 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 887YU UT WOS:000299971800028 PM 22079074 ER PT J AU Coleman, MS Garbat-Welch, L Burke, H Weinberg, M Humbaugh, K Tindall, A Cambron, J AF Coleman, Margaret S. Garbat-Welch, Luta Burke, Heather Weinberg, Michelle Humbaugh, Kraig Tindall, Alicia Cambron, Janie TI Direct costs of a single case of refugee-imported measles in Kentucky SO VACCINE LA English DT Article DE Cost; Contact tracing; Measles; Refugees ID UNITED-STATES; ECONOMIC-IMPACT; SAN-DIEGO; OUTBREAK; CALIFORNIA AB Background: Refugees are highly vulnerable populations with limited access to health care services. The United States accepts 50,000-75,000 refugees for resettlement annually. Despite residing in camps and other locations where vaccine-preventable disease outbreaks, such as measles, occur frequently, refugees are not required to have any vaccinations before they arrive in the United States. Purpose: We estimated the medical and public-health response costs of a case of measles imported into Kentucky by a refugee. Methods: The Kentucky Refugee Health Coordinator recorded the time and labor of local, state, and some federal personnel involved in caring for the refugee and implementing the public health response activities. Secondary sources were used to estimate the labor and medical care costs of the event. Results: The total costs to conduct the response to the disease event were approximately $25,000. All costs were incurred by government, either public health department or federal, because refugee health costs are paid by the federal government and the event response costs are covered by the public health department. Conclusion: A potentially preventable case of measles that was imported into the United States cost approximately $25,000 for the public health response. Recommendation: To maintain the elimination of measles transmission in the United States, U.S.-bound refugees should be vaccinated overseas. A refugee vaccination program administered during the overseas health assessment has the potential to reduce the risk of importation of measles and other vaccine-preventable disease and would eliminate costs associated with public health response to imported cases and outbreaks. Published by Elsevier Ltd. C1 [Coleman, Margaret S.; Burke, Heather; Weinberg, Michelle] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA 30333 USA. [Garbat-Welch, Luta] Kentucky Off Refugees, Louisville, KY 40204 USA. [Humbaugh, Kraig; Tindall, Alicia] Kentucky Dept Publ Hlth, Frankfort, KY 40621 USA. [Cambron, Janie] Green River Dist Hlth Dept, Owensboro, KY 42303 USA. RP Coleman, MS (reprint author), Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, MS E-03,1600 Clifton Rd, Atlanta, GA 30333 USA. EM mcoleman@cdc.gov; lgarbatwelch@archlou.org; hburke@cdc.gov; mweinberg@cdc.gov; kraig.humbaugh@ky.gov; Alicia.tindall@ky.gov; janie.cambron@grdhd.org NR 22 TC 12 Z9 12 U1 1 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JAN 5 PY 2012 VL 30 IS 2 BP 317 EP 321 DI 10.1016/j.vaccine.2011.10.091 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 887YU UT WOS:000299971800031 PM 22085555 ER PT J AU Garcia, S Lagos, R Munoz, A Picon, T Rosa, R Alfonso, A Abriata, G Gentile, A Romanin, V Regueira, M Chiavetta, L Agudelo, CI Castaneda, E De la Hoz, F Higuera, AB Arce, P Cohen, AL Verani, J Zuber, P Gabastou, JM Pastor, D Flannery, B Andrus, J AF Garcia, Salvador Lagos, Rosanna Munoz, Alma Picon, Teresa Rosa, Raquel Alfonso, Adriana Abriata, Graciela Gentile, Angela Romanin, Viviana Regueira, Mabel Chiavetta, Laura Ines Agudelo, Clara Castaneda, Elizabeth De la Hoz, Fernando Betty Higuera, Ana Arce, Patricia Cohen, Adam L. Verani, Jennifer Zuber, Patrick Gabastou, Jean-Marc Pastor, Desiree Flannery, Brendan Andrus, Jon TI Impact of vaccination against Haemophilus influenzae type b with and without a booster dose on meningitis in four South American countries SO VACCINE LA English DT Article DE Haemophilus influenzae type b; Conjugate vaccine; Vaccination schedules; Latin America ID CONJUGATE VACCINE; STREPTOCOCCUS-PNEUMONIAE; ACELLULAR PERTUSSIS; UNITED-KINGDOM; LATIN-AMERICA; HIB DISEASE; CHILDREN; REEMERGENCE; ROUTINE; IMMUNIZATION AB To inform World Health Organization recommendations regarding use of Haemophilus influenzae type b (Hib) vaccines in national immunization programs, a multi-country evaluation of trends in Hib meningitis incidence and prevalence of nasopharyngeal Hib carriage was conducted in four South American countries using either a primary, three-dose immunization schedule without a booster dose or with a booster dose in the second year of life. Surveillance data suggest that high coverage of Hib conjugate vaccine sustained low incidence of Hib meningitis and low prevalence of Hib carriage whether or not a booster dose was used. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Garcia, Salvador; Gabastou, Jean-Marc; Pastor, Desiree; Flannery, Brendan; Andrus, Jon] Pan Amer Hlth Org, Washington, DC USA. [Lagos, Rosanna; Munoz, Alma] Ctr Vacunas Desarrollo CVD Chile, Santiago, Chile. [Picon, Teresa; Rosa, Raquel; Alfonso, Adriana] Minist Hlth, Natl Immunizat Program, Montevideo, Uruguay. [Picon, Teresa; Rosa, Raquel; Alfonso, Adriana] Minist Hlth, Dept Epidemiol Surveillance, Montevideo, Uruguay. [Abriata, Graciela] Minist Salud Nac, Inst Nacl Canc, Buenos Aires, DF, Argentina. [Gentile, Angela; Romanin, Viviana] Hosp Ninos Dr Ricardo Gutierrez, Buenos Aires, DF, Argentina. [Regueira, Mabel; Chiavetta, Laura] Inst Nacl Enfermedades Infecciosas ANLIS Doctor C, Buenos Aires, DF, Argentina. [Ines Agudelo, Clara; Castaneda, Elizabeth] Inst Nacl Salud, Bogota, Colombia. [De la Hoz, Fernando] Univ Nacl Colombia, Fac Med, Dept Salud Publ, Bogota, Colombia. [Betty Higuera, Ana; Arce, Patricia] Secretaria Salud Bogota, Bogota, Colombia. [Cohen, Adam L.; Verani, Jennifer] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Zuber, Patrick] World Hlth Org, Dept Immunizat Vaccines & Biol, Geneva, Switzerland. RP Garcia, S (reprint author), Pan Amer Hlth Org, Marcelo T de Alvear 684,4To Piso,C1058AAH, Buenos Aires, DF, Argentina. EM garciasa@paho.org FU Immunizations Unit of the Pan American Health Organization, Washington, DC; World Health Organization, Geneva FX The multi-country evaluation was funded by the Immunizations Unit of the Pan American Health Organization, Washington, DC and World Health Organization, Geneva. Salvador Garcia, Jean-Marc Gabastou, Desiree Pastor, Brendan Flannery and Jon Andrus work for the Pan American Health Organization. Patrick Zuber works for the World Health Organization. NR 37 TC 5 Z9 6 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JAN 5 PY 2012 VL 30 IS 2 BP 486 EP 492 DI 10.1016/j.vaccine.2011.10.101 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 887YU UT WOS:000299971800052 PM 22085550 ER PT J AU McMullan, LK Frace, M Sammons, SA Shoemaker, T Balinandi, S Wamala, JF Lutwama, JJ Downing, RG Stroeher, U MacNeil, A Nichol, ST AF McMullan, Laura K. Frace, Mike Sammons, Scott A. Shoemaker, Trevor Balinandi, Stephen Wamala, Joseph F. Lutwama, Julius J. Downing, Robert G. Stroeher, Ute MacNeil, Adam Nichol, Stuart T. TI Using next generation sequencing to identify yellow fever virus in Uganda SO VIROLOGY LA English DT Article DE Pathogen discovery; Next generation sequencing; Metagenomics; Yellow fever virus ID AFRICA; EVOLUTION; STRAINS; EAST AB In October and November 2010, hospitals in northern Uganda reported patients with suspected hemorrhagic fevers. Initial tests for Ebola viruses, Marburg virus. Rift Valley fever virus, and Crimean Congo hemorrhagic fever virus were negative. Unbiased PCR amplification of total RNA extracted directly from patient sera and next generation sequencing resulted in detection of yellow fever virus and generation of 98% of the virus genome sequence. This finding demonstrated the utility of next generation sequencing and a metagenomic approach to identify an etiological agent and direct the response to a disease outbreak. (C) 2011 Published by Elsevier Inc. C1 [McMullan, Laura K.; Shoemaker, Trevor; Balinandi, Stephen; Stroeher, Ute; MacNeil, Adam; Nichol, Stuart T.] Ctr Dis Control & Prevent, Virus Special Pathogens Branch, Atlanta, GA 30329 USA. [Frace, Mike; Sammons, Scott A.] Ctr Dis Control & Prevent, Biotechnol Core Facil Branch, Atlanta, GA 30329 USA. [Shoemaker, Trevor; Balinandi, Stephen; Lutwama, Julius J.] Uganda Virus Res Inst, Entebbe, Uganda. [Wamala, Joseph F.] Uganda Minist Hlth, Kampala, Uganda. [Downing, Robert G.] Ctr Dis Control & Prevent, Entebbe, Uganda. RP Nichol, ST (reprint author), Ctr Dis Control & Prevent, Virus Special Pathogens Branch, 1600 Clifton Rd,MS G14, Atlanta, GA 30329 USA. EM stn1@cdc.gov NR 26 TC 20 Z9 20 U1 0 U2 6 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD JAN 5 PY 2012 VL 422 IS 1 BP 1 EP 5 DI 10.1016/j.virol.2011.08.024 PG 5 WC Virology SC Virology GA 859UW UT WOS:000297902300001 PM 21962764 ER PT J AU McElroy, AK Nichol, ST AF McElroy, Anita K. Nichol, Stuart T. TI Rift Valley fever virus inhibits a pro-inflammatory response in experimentally infected human monocyte derived macrophages and a pro-inflammatory cytokine response may be associated with patient survival during natural infection SO VIROLOGY LA English DT Article DE Rift Valley fever virus; RVFV; Interferon; Tumor necrosis factor; Immunity; Cytokine; Monocyte; Macrophage; Survival; Hemorrhagic fever ID CONGO HEMORRHAGIC-FEVER; HUMAN DENDRITIC CELLS; NECROSIS-FACTOR-ALPHA; INTERFERON-PRODUCTION; NSS PROTEIN; EBOLA-VIRUS; IFN-ALPHA; MOUSE MODEL; TNF-ALPHA; EXPRESSION AB Rift Valley fever virus (RVFV) causes significant morbidity and mortality in humans and livestock throughout Africa and the Middle East. The clinical disease ranges from mild febrile illness, to hepatitis, retinitis, encephalitis and fatal hemorrhagic fever. RVFV NSs protein has previously been shown to interfere in vitro with the interferon response, and RVFV lacking the NSs protein is attenuated in several animal models. Monocytes and macrophages are key players in the innate immune response via expression of various cytokines and chemokines. Here we demonstrate that wild-type RVFV infection of human monocyte-derived macrophages leads to a productive infection and inhibition of the innate immune response via decreased expression of IFN-alpha 2, IFN-beta and TNF-alpha. Using a recombinant virus lacking the NSs protein, we show that this effect is mediated by the viral NSs protein. Finally, analysis of RVF patient samples demonstrated an association between a pro-inflammatory cytokine response and patient survival. Published by Elsevier Inc. C1 [McElroy, Anita K.; Nichol, Stuart T.] Ctr Dis Control, Viral Special Pathogens Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA 30333 USA. [McElroy, Anita K.] Emory Univ, Dept Pediat, Div Infect Dis, Atlanta, GA 30322 USA. RP Nichol, ST (reprint author), Ctr Dis Control, Viral Special Pathogens Branch, Div High Consequence Pathogens & Pathol, 1600 Clifton Rd,MS G14, Atlanta, GA 30333 USA. EM gsz5@cdc.gov; stn1@cdc.gov NR 56 TC 24 Z9 24 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD JAN 5 PY 2012 VL 422 IS 1 BP 6 EP 12 DI 10.1016/j.virol.2011.09.023 PG 7 WC Virology SC Virology GA 859UW UT WOS:000297902300002 PM 22018491 ER PT J AU Chen, LM Blixt, O Stevens, J Lipatov, AS Davis, CT Collins, BE Cox, NJ Paulson, JC Donis, RO AF Chen, Li-Mei Blixt, Ola Stevens, James Lipatov, Aleksandr S. Davis, Charles T. Collins, Brian E. Cox, Nancy J. Paulson, James C. Donis, Ruben O. TI In vitro evolution of H5N1 avian influenza virus toward human-type receptor specificity SO VIROLOGY LA English DT Article DE Highly pathogenic avian influenza virus; Hemagglutinin; Host cell receptor; Virus attachment; H5N1; Sialoglycan; Host range; Pandemic virus emergence ID A-VIRUS; BINDING PROPERTIES; HEMAGGLUTININ; TRANSMISSION; CELLS; REPLICATION; FERRETS; RECOGNITION; MUTATIONS; INFECTION AB Acquisition of alpha 2-6 sialoside receptor specificity by alpha 2-3 specific highly-pathogenic avian influenza viruses (H5N1) is thought to be a prerequisite for efficient transmission in humans. By in vitro selection for binding alpha 2-6 sialosides, we identified four variant viruses with amino acid substitutions in the hemagglutinin (S227N, D187G. E190G, and Q196R) that revealed modestly increased alpha 2-6 and minimally decreased alpha 2-3 binding by glycan array analysis. However, a mutant virus combining Q196R with mutations from previous pandemic viruses (Q226L and G228S) revealed predominantly alpha 2-6 binding. Unlike the wild type H5N1, this mutant virus was transmitted by direct contact in the ferret model although not by airborne respiratory droplets. However, a reassortant virus with the mutant hemagglutinin, a human N2 neuraminidase and internal genes from an H5N1 virus was partially transmitted via respiratory droplets. The complex changes required for airborne transmissibility in ferrets suggest that extensive evolution is needed for H5N1 transmissibility in humans. Published by Elsevier Inc. C1 [Chen, Li-Mei; Stevens, James; Lipatov, Aleksandr S.; Davis, Charles T.; Cox, Nancy J.; Donis, Ruben O.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA. [Blixt, Ola; Collins, Brian E.; Paulson, James C.] Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USA. [Stevens, James] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA. [Blixt, Ola; Collins, Brian E.; Paulson, James C.] Scripps Res Inst, Consortium Funct Glyc, La Jolla, CA 92037 USA. RP Donis, RO (reprint author), Ctr Dis Control & Prevent, Influenza Div, Mailstop G-16,1600 Clifton Rd, Atlanta, GA 30333 USA. EM rdonis@cdc.gov RI Wei, Jianjian/F-7788-2011 OI Wei, Jianjian/0000-0001-8859-8462 FU National Institute of General Medical Sciences [GM62116]; Consortium for Functional Glycomics [GM62116] FX Glycan microarrays were produced for the Centers for Disease Control using the glycan library of CFG developed under funding by the National Institute of General Medical Sciences, Grant GM62116. We thank Dr. Kenneth Earhart (NAMRU-3, Cairo), the Ministry of Public Health of Egypt and Dr. Le Quynh Mai, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam, for providing H5N1 viruses. We thank Jacqueline Katz for providing A/Memphis/12/1988 (H3N2) virus seed and M. Jaber Hossain for help and advice on animal studies. We wish to acknowledge the Consortium for Functional Glycomics Grant GM62116 for synthetic glycans used in binding assays. We also thank the Centers for Disease Control Animal Resources Branch for exceptional animal care and Anna Crie for assistence in manuscript preparation. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention or the Agency for Toxic Substances and Disease Registry. NR 59 TC 88 Z9 94 U1 3 U2 34 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD JAN 5 PY 2012 VL 422 IS 1 BP 105 EP 113 DI 10.1016/j.virol.2011.10.006 PG 9 WC Virology SC Virology GA 859UW UT WOS:000297902300012 PM 22056389 ER PT J AU Shu, B Garten, R Emery, S Balish, A Cooper, L Sessions, W Deyde, V Smith, C Berman, L Klimov, A Lindstrom, S Xu, XY AF Shu, Bo Garten, Rebecca Emery, Shannon Balish, Amanda Cooper, Lynn Sessions, Wendy Deyde, Varough Smith, Catherine Berman, LaShondra Klimov, Alexander Lindstrom, Stephen Xu, Xiyan TI Genetic analysis and antigenic characterization of swine origin influenza viruses isolated from humans in the United States, 1990-2010 SO VIROLOGY LA English DT Article DE Swine origin influenza viruses; Triple reassortants ID A VIRUSES; 2 CHILDREN; INFECTION; PIGS; PB1-F2; TRANSMISSION; PATHOGENESIS; PREVALENCE; FERRETS; PROTEIN AB Swine influenza viruses (SIV) have been recognized as important pathogens for pigs and occasional human infections with swine origin influenza viruses (SOIV) have been reported. Between 1990 and 2010, a total of twenty seven human cases of SOIV infections have been identified in the United States. Six viruses isolated from 1990 to 1995 were recognized as classical SOIV (cSOIV) A(H1N1). After 1998, twenty-one SOIV recovered from human cases were characterized as triple reassortant (tr_SOIV) inheriting genes from classical swine, avian and human influenza viruses. Of those twenty-one tr_SOIV, thirteen were of A(H1N1), one of A(H1N2), and seven of A(H3N2) subtype. SOIV characterized were antigenically and genetically closely related to the subtypes of influenza viruses circulating in pigs but distinct from contemporary influenza viruses circulating in humans. The diversity of subtypes and genetic lineages in SOIV cases highlights the importance of continued surveillance at the animal-human interface. (C) 2011 Published by Elsevier Inc. C1 [Xu, Xiyan] Ctr Dis Control & Prevent, Virus Surveillance & Diagnost Branch, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30329 USA. [Cooper, Lynn] Mitre Corp, Mclean, VA 22102 USA. [Deyde, Varough] Ctr Dis Control & Prevent Nigeria, Abuja, Nigeria. RP Xu, XY (reprint author), Ctr Dis Control & Prevent, Virus Surveillance & Diagnost Branch, Influenza Div, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd,MS-G16, Atlanta, GA 30329 USA. EM XXu@cdc.gov NR 53 TC 47 Z9 50 U1 1 U2 8 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD JAN 5 PY 2012 VL 422 IS 1 BP 151 EP 160 DI 10.1016/j.virol.2011.10.016 PG 10 WC Virology SC Virology GA 859UW UT WOS:000297902300017 PM 22078166 ER PT J AU Reed, C Madhi, SA Klugman, KP Kuwanda, L Ortiz, JR Finelli, L Fry, AM AF Reed, Carrie Madhi, Shabir A. Klugman, Keith P. Kuwanda, Locadiah Ortiz, Justin R. Finelli, Lyn Fry, Alicia M. TI Development of the Respiratory Index of Severity in Children (RISC) Score among Young Children with Respiratory Infections in South Africa SO PLOS ONE LA English DT Article ID PNEUMOCOCCAL CONJUGATE VACCINE; COMMUNITY-ACQUIRED PNEUMONIA; PAPUA-NEW-GUINEA; DEVELOPING-COUNTRIES; CLINICAL SIGNS; VALIDATION; MULTICENTER; MANAGEMENT; FACILITIES; DERIVATION AB Objective: Pneumonia is a leading cause of death in children worldwide. A simple clinical score predicting the probability of death in a young child with lower respiratory tract infection (LRTI) could aid clinicians in case management and provide a standardized severity measure during epidemiologic studies. Methods: We analyzed 4,148 LRTI hospitalizations in children <24 months enrolled in a pneumococcal conjugate vaccine trial in South Africa from 1998-2001, to develop the Respiratory Index of Severity in Children (RISC). Using clinical data at admission, a multivariable logistic regression model for mortality was developed and statistically evaluated using bootstrap resampling techniques. Points were assigned to risk factors based on their coefficients in the multivariable model. A child's RISC score is the sum of points for each risk factor present. Separate models were developed for HIV-infected and noninfected children. Results: Significant risk factors for HIV-infected and non-infected children included low oxygen saturation, chest indrawing, wheezing, and refusal to feed. The models also included age and HIV clinical classification (for HIV-infected children) or weight-for-age (for non-infected children). RISC scores ranged up to 7 points for HIV-infected or 6 points for non-infected children and correlated with probability of death (0-47%, HIV-infected; 0-14%, non-infected). Final models showed good discrimination (area under the ROC curve) and calibration (goodness-of-fit). Conclusion: The RISC score incorporates a simple set of risk factors that accurately discriminate between young children based on their risk of death from LRTI, and may provide an objective means to quantify severity based on the risk of mortality. C1 [Reed, Carrie; Finelli, Lyn; Fry, Alicia M.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Reed, Carrie; Ortiz, Justin R.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA USA. [Madhi, Shabir A.; Klugman, Keith P.; Kuwanda, Locadiah] Univ Witwatersrand, Resp & Meningeal Pathogens Res Unit, Dept Sci & Technol, Natl Res Fdn,Vaccine Preventable Dis & Med Res Co, Bertsham, South Africa. [Madhi, Shabir A.; Klugman, Keith P.] Emory Univ, Hubert Dept Publ Hlth, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Ortiz, Justin R.] Univ Washington, Seattle, WA 98195 USA. RP Reed, C (reprint author), Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM creed1@cdc.gov NR 32 TC 27 Z9 27 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 4 PY 2012 VL 7 IS 1 AR e27793 DI 10.1371/journal.pone.0027793 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 902VE UT WOS:000301070200002 PM 22238570 ER PT J AU Burrows, NR Hora, IA Li, YF Saaddine, JB AF Burrows, Nilka R. Hora, Israel A. Li, Yanfeng Saaddine, Jinan B. TI Self-Reported Visual Impairment Among Persons With Diagnosed Diabetes-United States, 1997-2010 (Reprinted from MMWR, vol 60, pg 1549-1553, 2011) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint ID RETINOPATHY; TRENDS C1 [Burrows, Nilka R.; Hora, Israel A.; Li, Yanfeng; Saaddine, Jinan B.] CDC, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Diabet Translat, Atlanta, GA 30333 USA. RP Burrows, NR (reprint author), CDC, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Diabet Translat, Atlanta, GA 30333 USA. EM nburrows@cdc.gov NR 11 TC 1 Z9 1 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JAN 4 PY 2012 VL 307 IS 1 BP 25 EP 27 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 872ET UT WOS:000298792300008 ER PT J AU McLaughlin, JB Fearey, DA Esposito, TA Porter, KA AF McLaughlin, Joseph B. Fearey, Donna A. Esposito, Tari A. Porter, Kimberly A. TI Paralytic Shellfish Poisoning-Southeast Alaska, May-June 2011 (Reprinted from MMWR, vol 60, pg 1554-1556, 2011) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [McLaughlin, Joseph B.; Fearey, Donna A.; Esposito, Tari A.; Porter, Kimberly A.] CDC, Alaska Div Publ Hlth, Atlanta, GA 30333 USA. RP Porter, KA (reprint author), CDC, Alaska Div Publ Hlth, Atlanta, GA 30333 USA. EM kaporter@cdc.gov NR 4 TC 0 Z9 0 U1 1 U2 3 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JAN 4 PY 2012 VL 307 IS 1 BP 29 EP 31 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 872ET UT WOS:000298792300010 ER PT J AU Broor, S Krishnan, A Roy, DS Dhakad, S Kaushik, S Mir, MA Singh, Y Moen, A Chadha, M Mishra, AC Lal, RB AF Broor, Shobha Krishnan, Anand Roy, Dipanjan S. Dhakad, Shivram Kaushik, Samander Mir, Muneer A. Singh, Yashpal Moen, Ann Chadha, Mandeep Mishra, Akhilesh C. Lal, Renu B. TI Dynamic Patterns of Circulating Seasonal and Pandemic A(H1N1)pdm09 Influenza Viruses From 2007-2010 in and around Delhi, India SO PLOS ONE LA English DT Article ID H1N1 2009 VIRUS; MORTALITY; TRANSMISSION; EMERGENCE; EPIDEMIC; EMPHASIS; IMPACT; EAST; ASIA; AGE AB Influenza surveillance was carried out in a subset of patients with influenza-like illness (ILI) presenting at an Employee Health Clinic (EHS) at All India Institute of Medical Sciences (AIIMS), New Delhi (urban) and pediatric out patients department of civil hospital at Ballabhgarh (peri-urban), under the Comprehensive Rural Health Services Project (CRHSP) of AIIMS, in Delhi region from January 2007 to December 2010. Of the 3264 samples tested, 541 (17%) were positive for influenza viruses, of which 221 (41%) were pandemic Influenza A(H1N1)pdm09, 168 (31%) were seasonal influenza A, and 152 (28%) were influenza B. While the Influenza viruses were detected year-round, their types/subtypes varied remarkably. While there was an equal distribution of seasonal A(H1N1) and influenza B in 2007, predominance of influenza B was observed in 2008. At the beginning of 2009, circulation of influenza A(H3N2) viruses was observed, followed later by emergence of Influenza A(H1N1) pdm09 with co-circulation of influenza B viruses. Influenza B was dominant subtype in early 2010, with second wave of Influenza A(H1N1) pdm09 in August-September, 2010. With the exception of pandemic H1N1 emergence in 2009, the peaks of influenza activity coincided primarily with monsoon season, followed by minor peak in winter at both urban and rural sites. Age group analysis of influenza positivity revealed that the percent positivity of Influenza A(H1N1) pdm09 influenza virus was highest in >5-18 years age groups (OR 2.5; CI = 1.2-5.0; p = 0.009) when compared to seasonal influenza. Phylogenetic analysis of Influenza A(H1N1) pdm09 from urban and rural sites did not reveal any major divergence from other Indian strains or viruses circulating worldwide. Continued surveillance globally will help define regional differences in influenza seasonality, as well as, to determine optimal periods to implement influenza vaccination programs among priority populations. C1 [Broor, Shobha; Krishnan, Anand; Dhakad, Shivram; Kaushik, Samander; Mir, Muneer A.; Singh, Yashpal] All India Inst Med Sci, Delhi, India. [Roy, Dipanjan S.; Moen, Ann; Lal, Renu B.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. [Chadha, Mandeep; Mishra, Akhilesh C.] Natl Inst Virol, Pune, Maharashtra, India. RP Broor, S (reprint author), All India Inst Med Sci, Delhi, India. EM shobha.broor@gmail.com OI Krishnan, Anand/0000-0002-9173-7811 FU Indian Council of Medical Research, New Delhi, India; Centers for Disease Control and Prevention, Atlanta, USA [5U50 CI 024407, IU51 IP 00033301] FX This study was supported in part by Indian Council of Medical Research, New Delhi, India and a cooperative agreement 5U50 CI 024407 and IU51 IP 00033301 from the Centers for Disease Control and Prevention, Atlanta, USA. The study is part of collaborative activity between AIIMS, New Delhi, and US CDC, whereby investigators from both side are involved in study design, implementation and data analysis. NR 36 TC 30 Z9 31 U1 0 U2 5 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 3 PY 2012 VL 7 IS 1 AR e29129 DI 10.1371/journal.pone.0029129 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 903NK UT WOS:000301123400026 PM 22235265 ER PT J AU Shay, CM Ning, HY Allen, NB Carnethon, MR Chiuve, SE Greenlund, KJ Daviglus, ML Lloyd-Jones, DM AF Shay, Christina M. Ning, Hongyan Allen, Norrina B. Carnethon, Mercedes R. Chiuve, Stephanie E. Greenlund, Kurt J. Daviglus, Martha L. Lloyd-Jones, Donald M. TI Status of Cardiovascular Health in US Adults Prevalence Estimates From the National Health and Nutrition Examination Surveys (NHANES) 2003-2008 SO CIRCULATION LA English DT Article DE cardiovascular diseases; diet; epidemiology; obesity; risk factors ID CORONARY-HEART-DISEASE; LIFE-STYLE; PRIMARY PREVENTION; MYOCARDIAL-INFARCTION; DIABETES-MELLITUS; DIET; RISK; REDUCTION; WOMEN; SALT AB Background-The American Heart Association's 2020 Strategic Impact Goals define a new concept, cardiovascular (CV) health; however, current prevalence estimates of the status of CV health in US adults according to age, sex, and race/ethnicity have not been published. Methods and Results-We included 14 515 adults (>= 20 years of age) from the 2003 to 2008 National Health and Nutrition Examination Surveys. Participants were stratified by young (20-39 years), middle (40-64 years), and older (>= 65 years) ages. CV health behaviors (diet, physical activity, body mass index, smoking) and CV health factors (blood pressure, total cholesterol, fasting blood glucose, smoking) were defined as poor, intermediate, or ideal. Fewer than 1% of adults exhibited ideal CV health for all 7 metrics. For CV health behaviors, nonsmoking was most prevalent (range, 60.2%-90.4%), whereas ideal Healthy Diet Score was least prevalent (range, 0.2%-2.6%) across groups. Prevalences of ideal body mass index (range, 36.5%-45.3%) and ideal physical activity levels (range, 50.2%-58.8%) were higher in young adults compared with middle or older ages. Ideal total cholesterol (range, 23.7%-36.2%), blood pressure (range, 11.9%-16.3%), and fasting blood glucose (range, 31.2%-42.9%) were lower in older adults compared with young and middle-aged adults. Prevalence of poor CV health factors was lowest in young age but higher at middle and older ages. Prevalence estimates by age and sex were consistent across race/ethnic groups. Conclusions-These prevalence estimates of CV health represent a starting point from which effectiveness of efforts to promote CV health and prevent CV disease can be monitored and compared in US adult populations. (Circulation. 2012;125:45-56.) C1 [Shay, Christina M.; Ning, Hongyan; Allen, Norrina B.; Carnethon, Mercedes R.; Daviglus, Martha L.; Lloyd-Jones, Donald M.] Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA. [Chiuve, Stephanie E.] Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA. [Chiuve, Stephanie E.] Harvard Univ, Sch Med, Boston, MA USA. [Chiuve, Stephanie E.] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. [Greenlund, Kurt J.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Atlanta, GA USA. RP Shay, CM (reprint author), Univ Oklahoma, Hlth Sci Ctr, Dept Biostat & Epidemiol, 801 NE 13th St, Oklahoma City, OK 73104 USA. EM christina-shay@ouhsc.edu RI Lloyd-Jones, Donald/C-5899-2009; OI Shay, Christina/0000-0002-8310-7043 FU National Heart, Lung, and Blood Institute [T32 HL 069771-07] FX This study was supported by grant T32 HL 069771-07 from the National Heart, Lung, and Blood Institute (principal investigator, Dr Daviglus). NR 35 TC 107 Z9 113 U1 2 U2 16 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD JAN 3 PY 2012 VL 125 IS 1 BP 45 EP U377 DI 10.1161/CIRCULATIONAHA.111.035733 PG 42 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 877HT UT WOS:000299169100018 PM 22095826 ER PT J AU Hanna, DB Selik, RM Tang, T Gange, SJ AF Hanna, David B. Selik, Richard M. Tang, Tian Gange, Stephen J. TI Disparities among US states in HIV-related mortality in persons with HIV infection, 2001-2007 SO AIDS LA English DT Article DE case-fatality rate; excess mortality; geographic factors; healthcare disparities; mortality determinants; surveillance; United States ID UNITED-STATES; ATTRIBUTABLE FRACTIONS; AIDS; ADULTS; CARE; SURVEILLANCE; DIAGNOSIS; HEALTH; TRENDS; DEATH AB Objective: To examine interstate variation in US HIV case-fatality rates, and compare them with corresponding conventional HIV death rates. Design: Cross-sectional analysis using data on deaths due to HIV infection from the National Vital Statistics System and data on persons 15 years or older living with HIV infection in 2001-2007 in 37 US states from the national HIV/AIDS Reporting System. Methods: State rankings by age-adjusted HIV case-fatality rates (with HIV-infected population denominators) were compared with rankings by conventional death rates (with general population denominators). Negative binomial regression determined case-fatality rate ratios among states, adjusted for age, sex, race/ethnicity, year, and state-level markers of late HIV diagnosis. Results: On the basis of 3 096 729 HIV-infected person-years, the overall HIV case-fatality rate was 20.6 per 1000 person-years [95% confidence interval (CI) 20.3-20.9]. Age-adjusted rates by state ranged from 9.6 (95% CI 6.8-12.4) in Idaho to 32.9 (95% CI 29.8-36.0) in Mississippi, demonstrating significant differences across states, even after adjusting for race/ethnicity (P < 0.0001). Many states with low conventional death rates had high case-fatality rates. Nine of the 10 states with the highest case-fatality rates were located in the southern United States. Conclusion: Case-fatality rates complement and are not entirely concordant with conventional death rates. Interstate differences in these rates may reflect differences in secondary and tertiary prevention of HIV-related mortality among infected persons. These data suggest that state-specific contextual barriers to care may impede improvements in quality and disparities of healthcare without targeted interventions. (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins C1 [Hanna, David B.; Gange, Stephen J.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA. [Selik, Richard M.; Tang, Tian] Ctr Dis Control & Prevent CDC, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div HIV AIDS Prevent, Atlanta, GA USA. RP Hanna, DB (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, 615 N Wolfe St,Room E7133, Baltimore, MD 21205 USA. EM dhanna@jhsph.edu OI Gange, Stephen/0000-0001-7842-512X FU National Institutes of Health [F31-DA-030254, U01-AI-042590, U01-AI-069918] FX This analysis was funded in part by National Institutes of Health grants F31-DA-030254, U01-AI-042590, and U01-AI-069918. The funding groups had no role in the study or the decision to approve publication of the finished manuscript. NR 39 TC 23 Z9 23 U1 1 U2 16 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 J9 AIDS JI Aids PD JAN 2 PY 2012 VL 26 IS 1 BP 95 EP 103 DI 10.1097/QAD.0b013e32834dcf87 PG 9 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 863BA UT WOS:000298136600011 PM 22008659 ER PT J AU Hillis, SD Zapata, L Robbins, CL Kissin, DM Skipalska, H Yorick, R Finnerty, E Marchbanks, PA Jamieson, DJ AF Hillis, Susan D. Zapata, Lauren Robbins, Cheryl L. Kissin, Dmitry M. Skipalska, Halyna Yorick, Roman Finnerty, Erin Marchbanks, Polly A. Jamieson, Denise J. TI HIV seroprevalence among orphaned and homeless youth: no place like home SO AIDS LA English DT Article; Proceedings Paper CT Conference of the Society-for-Epidemiologic-Research CY 2009 CL Seattle, WA SP Soc Epidemiol Res DE epidemiology; Europe; HIV; homeless; orphan ID HUMAN-IMMUNODEFICIENCY-VIRUS; SEXUAL RISK; IMMUNOCHROMATOGRAPHIC TEST; ANTIRETROVIRAL THERAPY; REPRODUCTIVE HEALTH; SAN-FRANCISCO; STREET YOUTH; ADOLESCENTS; PREVENTION; INFECTION AB Objectives: We evaluated the combined influences of orphaned status and homelessness on HIV seroprevalence and risk among street-involved Ukrainian youth in 2008. Design: Systematic, multicity, community-based, cross-sectional assessment. Methods: Time-location sampling was used to identify eligible youth aged 15-24 after city-wide mapping of 91 sites where street-involved youth gathered in Odessa, Kiev, and Donetsk. Universal sampling identified 961 youth in 74 randomly selected sites; 97% consented. Youth reporting one or both parents dead were classified as orphaned; those without a stable residence or sleeping outside their residence at least two nights per week were classified as homeless. Trained staff provided HIV counseling and rapid testing via mobile vans. Adjusted odds ratios (AORs) were calculated using logistic regression, accounting for intracluster homogeneity. Results: We found 32% (300 of 929) were both orphaned and homeless; 48% either (but not both) homeless [37% (343 of 929)] or orphaned [11% (104 of 929)]; and [20% (182 of 929)] neither orphaned nor homeless. HIV seroprevalences were 7% for neither orphaned/homeless; 16 and 17%, respectively, for either orphaned/homeless; 28% for both orphaned/homeless (P for trend <0.0001). AORs for HIV infection were 1 for neither; 2.3 and 2.4 for either homeless [95% confidence interval (CI) 1.7-2.9] or orphaned (CI 1.8-3.3); 3.3 for both orphaned/homeless (CI 2.3-4.4). Ever-use of injection drugs increased from 15 to 32 to 48% for those who neither, either, or both orphaned and homeless, respectively (P for trend <0.0001). Conclusions: One of four youths who were both homeless and orphaned was HIV-infected; these youths were significantly more likely to be HIV infected and to report injection drug use than those with adequate housing and living parents. (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins C1 [Finnerty, Erin] HealthRight Int, New York, NY USA. RP Hillis, SD (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,Mailstop K 34, Atlanta, GA 30341 USA. EM seh0@cdc.gov NR 38 TC 17 Z9 20 U1 1 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 J9 AIDS JI Aids PD JAN 2 PY 2012 VL 26 IS 1 BP 105 EP 110 DI 10.1097/QAD.0b013e32834c4be4 PG 6 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 863BA UT WOS:000298136600012 PM 21881479 ER PT B AU Crews, JE Talley, RC AF Crews, John E. Talley, Ronda C. BE Talley, RC Crews, JE TI Introduction: Multiple Dimensions of Caregiving and Disability SO MULTIPLE DIMENSIONS OF CAREGIVING AND DISABILITY: RESEARCH, PRACTICE, POLICY SE Caregiving-Research Practice Policy LA English DT Editorial Material; Book Chapter C1 [Crews, John E.] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA 30341 USA. [Talley, Ronda C.] Western Kentucky Univ, Bowling Green, KY 42101 USA. RP Crews, JE (reprint author), Ctr Dis Control & Prevent, Div Diabet Translat, 4770 Buford Highway,NE,K-10, Atlanta, GA 30341 USA. EM jcrews@cdc.gov; Ronda.Talley@wku.edu NR 11 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4614-3383-5 J9 CAREGIVING-RES PRACT PY 2012 BP 1 EP 10 DI 10.1007/978-1-4614-3384-2_1 D2 10.1007/978-1-4614-3384-2 PG 10 WC Health Policy & Services; Social Work SC Health Care Sciences & Services; Social Work GA BGN70 UT WOS:000323583000002 ER PT B AU Crews, JE AF Crews, John E. BE Talley, RC Crews, JE TI Neither Prepared Nor Rehearsed: The Role of Public Health in Disability and Caregiving SO MULTIPLE DIMENSIONS OF CAREGIVING AND DISABILITY: RESEARCH, PRACTICE, POLICY SE Caregiving-Research Practice Policy LA English DT Article; Book Chapter ID SPOUSAL CAREGIVERS; MENTAL-HEALTH; ILLNESS; ADULTS; CHILD; CARE C1 Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA 30341 USA. RP Crews, JE (reprint author), Ctr Dis Control & Prevent, Div Diabet Translat, 4770 Buford Highway,NE,K-10, Atlanta, GA 30341 USA. EM jcrews@cdc.gov NR 38 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4614-3383-5 J9 CAREGIVING-RES PRACT PY 2012 BP 83 EP 97 DI 10.1007/978-1-4614-3384-2_6 D2 10.1007/978-1-4614-3384-2 PG 15 WC Health Policy & Services; Social Work SC Health Care Sciences & Services; Social Work GA BGN70 UT WOS:000323583000007 ER PT B AU Talley, RC Crews, JE AF Talley, Ronda C. Crews, John E. BE Talley, RC Crews, JE TI Multiple Dimensions of Caregiving and Disability: Supporting Those Who Care SO MULTIPLE DIMENSIONS OF CAREGIVING AND DISABILITY: RESEARCH, PRACTICE, POLICY SE Caregiving-Research Practice Policy LA English DT Article; Book Chapter ID CHILDREN; PARENTS; HEALTH C1 [Talley, Ronda C.] Western Kentucky Univ, Bowling Green, KY 42101 USA. [Crews, John E.] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA 30341 USA. RP Talley, RC (reprint author), Western Kentucky Univ, 1906 Coll Hts Blvd, Bowling Green, KY 42101 USA. EM ronda.talley@wku.edu; jcrews@cdc.gov NR 30 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4614-3383-5 J9 CAREGIVING-RES PRACT PY 2012 BP 209 EP 214 DI 10.1007/978-1-4614-3384-2_13 D2 10.1007/978-1-4614-3384-2 PG 6 WC Health Policy & Services; Social Work SC Health Care Sciences & Services; Social Work GA BGN70 UT WOS:000323583000014 ER PT S AU Sehulster, LM AF Sehulster, L. M. BE Lerouge, S Simmons, A TI Prions and endotoxins: reprocessing strategies for reusable medical devices SO STERILISATION OF BIOMATERIALS AND MEDICAL DEVICES SE Woodhead Publishing Series in Biomaterials LA English DT Article; Book Chapter DE prions; Creutzfeldt-Jakob disease (CJD); variant Creutzfeldt-Jakob disease (vCJD); prion decontamination; cleaning agents; steam sterilization; endotoxin; water treatment; dry heat ID CREUTZFELDT-JAKOB-DISEASE; SURGICAL STAINLESS-STEEL; TUMOR NECROSIS FACTOR; TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES; ANTERIOR SEGMENT SYNDROME; DRY HEAT INACTIVATION; CEREBROSPINAL-FLUID; BLOOD-TRANSFUSION; SCRAPIE AGENT; PROTEIN CONTAMINATION AB The apparent high level of resistance of Creutzfeldt-Jakob disease (CJD) and variant Creutzfeldt-Jakob disease (vCJD) prions to inactivation by conventional means of device reprocessing poses an infection prevention challenge to a hospital's central sterilization department. This chapter will focus on prion inactivation methods for instrument reprocessing that are currently recommended by public health agencies for the prevention of iatrogenic transmissible spongiform encephalopathy (TSE) transmission. Important factors such as cleaning/decontamination efficacy and steel quality are discussed. Research continues to evaluate the potential use of alternative sterilizing agents and methods for prion inactivation. Additionally, the reprocessing strategies for the removal or inactivation of bacterial endotoxin are discussed briefly. C1 Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. RP Sehulster, LM (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, 1600 Clifton Rd NE,Mailstop A-35, Atlanta, GA 30333 USA. EM LSehulster@cdc.gov NR 163 TC 0 Z9 0 U1 0 U2 5 PU WOODHEAD PUBL LTD PI CAMBRIDGE PA ABINGTON HALL ABINGTON, CAMBRIDGE CB1 6AH, CAMBS, ENGLAND SN 2049-9485 BN 978-0-85709-626-5; 978-1-84569-932-1 J9 WOODH PUBL SER BIOM PY 2012 VL 46 BP 261 EP 309 D2 10.1533/9780857096265 PG 49 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA BGQ62 UT WOS:000323816800010 ER PT J AU Krauss, BJ Miller, KS AF Krauss, Beatrice J. Miller, Kim S. BE Pequegnat, W Bell, CC TI Parents as HIV/AIDS Educators SO FAMILY AND HIV/AIDS: CULTURAL AND CONTEXTUAL ISSUES IN PREVENTION AND TREATMENT LA English DT Article; Book Chapter ID ADOLESCENT SEXUAL-BEHAVIOR; RURAL WESTERN KENYA; RISK BEHAVIORS; RANDOMIZED-TRIAL; AMERICAN ADOLESCENTS; COLLECTIVE EFFICACY; FAMILIES MATTER; UNITED-STATES; SUBSTANCE USE; CONDOM USE AB Parents and caregivers play a special role in HIV prevention efforts for youth. Parents are able to reach youth early and in a non-controversial way. Parents can engage in continuous discussions about sex and sexuality, HIV, substance use, and sexual risk prevention. Having frequent contact with their children allows them to provide sequential and time-sensitive information that is immediately responsive to the child's questions and anticipated needs. Parents and caregivers help youth shape and form healthy attitudes and behaviors, and support youth with supervision, positive reinforcement and skills building. Given the proper tools to harness their parenting and communication skills, parents and caregivers are a force to be reckoned with. There is a growing literature that highlights the important role parents and caregivers play in addressing teen substance use and sexual risk behavior; however, evidence-based interventions to strengthen parents' role in HIV prevention or even in reproductive health promotion are rare and not widely disseminated. This chapter describes two evidence-based interventions, Parents Matter! and the Parent/Preadolescent Training for HIV (PATH) Prevention. Both are based on research addressing the need to intervene early, child parent communication, and risk reduction science and strategies. Data on outcomes and description of the dissemination of these interventions are presented. Among the intriguing findings are that both projects were easily accepted by communities, both led to reported risk reduction or intention to reduce risk, and that improved communication may have generalized to create positive outcomes for risks other than those associated with HIV. Each intervention has found new audiences, through formal and informal pathways. A continuing challenge is to maintain and update interventions as new risks emerge and as new populations are at risk as the HIV epidemic changes. C1 [Krauss, Beatrice J.] CUNY Hunter Coll, Sch Publ Hlth, New York, NY 10021 USA. [Miller, Kim S.] Ctr Dis Control & Prevent, Ctr Global Hlth, Div Global HIV AIDS Prevent, Atlanta, GA 30333 USA. RP Krauss, BJ (reprint author), CUNY Hunter Coll, Sch Publ Hlth, New York, NY 10021 USA. NR 120 TC 3 Z9 3 U1 0 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4614-0439-2 PY 2012 BP 97 EP 120 DI 10.1007/978-1-4614-0439-2_4 D2 10.1007/978-1-4614-0439-2 PG 24 WC Family Studies; Public, Environmental & Occupational Health SC Family Studies; Public, Environmental & Occupational Health GA BGJ68 UT WOS:000323234400006 ER PT J AU Katz, KA Pierce, EF AF Katz, Kenneth A. Pierce, Elaine F. TI A torso rash and anogenital lesions SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Editorial Material RP Katz, KA (reprint author), CDC Box 68, APO, AP 96546 USA. EM Kenneth.Katz@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD JAN PY 2012 VL 66 IS 1 BP E3 EP E4 DI 10.1016/j.jaad.2011.01.002 PG 2 WC Dermatology SC Dermatology GA 205NY UT WOS:000323452300002 ER PT J AU Fadeel, B Pietroiusti, A Shvedova, AA AF Fadeel, Bengt Pietroiusti, Antonio Shvedova, Anna A. BE Fadeel, B Pietroiusti, A Shvedova, AA TI ADVERSE EFFECTS OF ENGINEERED NANOMATERIALS EXPOSURE, TOXICOLOGY, AND IMPACT ON HUMAN HEALTH Preface SO ADVERSE EFFECTS OF ENGINEERED NANOMATERIALS: EXPOSURE, TOXICOLOGY, AND IMPACT ON HUMAN HEALTH LA English DT Editorial Material; Book Chapter C1 [Fadeel, Bengt] Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden. [Pietroiusti, Antonio] Univ Roma Tor Vergata, Fac Med, Dept Biopathol, Rome, Italy. [Pietroiusti, Antonio] Univ Roma Tor Vergata, Fac Odontostomatol, Rome, Italy. [Pietroiusti, Antonio] Univ Roma Tor Vergata, Specializat Sch Internal Med, Rome, Italy. [Shvedova, Anna A.] NIOSH, Ctr Dis Control & Prevent CDC, Washington, DC 20201 USA. [Shvedova, Anna A.] W Virginia Univ, Sch Med, Dept Physiol & Pharmacol, Morgantown, WV 26506 USA. RP Fadeel, B (reprint author), Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden. NR 0 TC 6 Z9 6 U1 1 U2 2 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA BN 978-0-12-386976-0 PY 2012 BP IX EP XI PG 3 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA BFT11 UT WOS:000321201700001 ER PT J AU Strait, K Else, JG Eberhard, ML AF Strait, Karen Else, James G. Eberhard, Mark L. BE Abee, CR Mansfield, K Tardif, S Morris, T TI Parasitic Diseases of Nonhuman Primates SO NONHUMAN PRIMATES IN BIOMEDICAL RESEARCH, VOL 2: DISEASES, 2ND EDITION SE American College of Laboratory Animal Medicine Series LA English DT Article; Book Chapter ID MONKEYS SAIMIRI-SCIUREUS; TRYPANOSOMA-CRUZI INFECTION; GORILLAS GORILLA-GORILLA; CHIMPANZEE PAN-TROGLODYTES; SP-N NEMATODA; SOUTH-AMERICAN MONKEYS; ECHINOCOCCUS-MULTILOCULARIS INFECTION; PTERYGODERMATITES-NYCTICEBI NEMATODA; SIMIAN IMMUNODEFICIENCY VIRUS; MARMOSETS CALLITHRIX-JACCHUS C1 [Strait, Karen; Else, James G.] Yerkes Natl Primate Ctr, Atlanta, GA USA. [Eberhard, Mark L.] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA. RP Strait, K (reprint author), Yerkes Natl Primate Ctr, Atlanta, GA USA. NR 976 TC 5 Z9 5 U1 0 U2 2 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA BN 978-0-12-397838-7 J9 AM COLL LAB PY 2012 BP 197 EP 297 DI 10.1016/B978-0-12-381366-4.00004-3 PG 101 WC Veterinary Sciences SC Veterinary Sciences GA BEO88 UT WOS:000317607800005 ER PT B AU Galinski, MR Barnwell, JW AF Galinski, Mary R. Barnwell, John W. BE Abee, CR Mansfield, K Tardif, S Morris, T TI Nonhuman Primate Models for Human Malaria Research SO NONHUMAN PRIMATES IN BIOMEDICAL RESEARCH, VOL 2: DISEASES, 2ND EDITION SE American College of Laboratory Animal Medicine Series LA English DT Article; Book Chapter ID PLASMODIUM-KNOWLESI MALARIA; MONKEY SAIMIRI-SCIUREUS; AOTUS-NANCYMAI MONKEYS; COATNEYI-INFECTED ERYTHROCYTES; CHLOROQUINE-RESISTANT STRAIN; DUFFY-BLOOD-GROUP; NEW-WORLD MONKEYS; MEROZOITE SURFACE PROTEIN-1; AZARAE-BOLIVIENSIS MONKEYS; CAVEOLA-VESICLE COMPLEXES C1 [Galinski, Mary R.] Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30322 USA. [Barnwell, John W.] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA USA. RP Galinski, MR (reprint author), Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30322 USA. NR 327 TC 12 Z9 12 U1 0 U2 0 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA BN 978-0-12-397838-7; 978-0-12-381366-4 J9 AM COLL LAB PY 2012 BP 299 EP 323 DI 10.1016/B978-0-12-381366-4.00005-5 PG 25 WC Veterinary Sciences SC Veterinary Sciences GA BEO88 UT WOS:000317607800006 ER PT J AU Bailey, RL Mills, JL Yetley, EA Gahche, JJ Pfeiffer, CM Dwyer, JT Dodd, KW Sempos, CT Betz, JM Picciano, MF AF Bailey, Regan L. Mills, James L. Yetley, Elizabeth A. Gahche, Jaime J. Pfeiffer, Christine M. Dwyer, Johanna T. Dodd, Kevin W. Sempos, Christopher T. Betz, Joseph M. Picciano, Mary Frances TI Serum unmetabolized folic acid in a nationally representative sample of adults >= 60 years in the United States, 2001-2002 SO FOOD & NUTRITION RESEARCH LA English DT Editorial Material DE folic acid; folate; NHANES; folic acid fortification ID FOLATE INTAKE; BLOOD FOLATE; CANCER-RISK; FORTIFICATION; TRIAL; VITAMIN-B-12; SUPPLEMENTS; WOMEN C1 [Bailey, Regan L.; Yetley, Elizabeth A.; Dwyer, Johanna T.; Sempos, Christopher T.; Betz, Joseph M.; Picciano, Mary Frances] NIH, Off Dietary Supplements, Bethesda, MD 20892 USA. [Mills, James L.] Eunice Kennedy Shriver Natl Inst Child & Human De, NIH, Div Epidemiol Stat & Prevent Res, Bethesda, MD USA. [Gahche, Jaime J.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Pfeiffer, Christine M.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. [Dodd, Kevin W.] NCI, NIH, Bethesda, MD 20892 USA. RP Bailey, RL (reprint author), NIH, RD Off Dietary Supplements, 6100 Execut Blvd,Rm 3B01, Bethesda, MD 20892 USA. EM baileyr@mail.nih.gov NR 16 TC 2 Z9 2 U1 1 U2 5 PU CO-ACTION PUBLISHING PI JARFALLA PA RIPVAGEN 7, JARFALLA, SE-175 64, SWEDEN SN 1654-6628 J9 FOOD NUTR RES JI Food Nutr. Res. PY 2012 VL 56 SU S AR 5616 DI 10.3402/fnr.v56i0.5616 PG 3 WC Food Science & Technology; Nutrition & Dietetics SC Food Science & Technology; Nutrition & Dietetics GA 119ZL UT WOS:000317138700012 ER PT J AU Pfeiffer, CM Schleicher, RL Johnson, CL Coates, PM AF Pfeiffer, Christine M. Schleicher, Rosemary L. Johnson, Clifford L. Coates, Paul M. TI Assessing vitamin status in large population surveys by measuring biomarkers and dietary intake - two case studies: folate and vitamin D SO FOOD & NUTRITION RESEARCH LA English DT Article DE nutrition survey; NHANES; monitoring; trend; biochemical indicator; nutrition status; food intake; dietary questionnaire; folate; vitamin D ID NUTRITION EXAMINATION SURVEY; SERUM 25-HYDROXYVITAMIN D; 3RD NATIONAL-HEALTH; UNITED-STATES; FOLIC-ACID; TOTAL HOMOCYSTEINE; US POPULATION; BLOOD FOLATE; FORTIFICATION; QUESTIONNAIRE AB The National Health and Nutrition Examination Survey (NHANES) provides the most comprehensive assessment of the health and nutrition status of the US population. Up-to-date reference intervals on biomarkers and dietary intake inform the scientific and public health policy communities on current status and trends over time. The main purpose of dietary assessment methods such as the food-frequency questionnaire, food record (or diary), and 24-hr dietary recall is to estimate intake of nutrients and, together with supplement usage information, describe total intake of various foods or nutrients. As with all self-reporting methods, these tools are challenging to use and interpret. Yet, they are needed to establish dietary reference intake recommendations and to evaluate what proportion of the population meets these recommendations. While biomarkers are generally expensive and, to some degree, invasive, there is no question as to their ability to assess nutrition status. In some cases biomarkers can also be used to assess intake or function, although rarely can one biomarker fulfill all these purposes. For example, serum folate is a good indicator of folate intake, red blood cell (RBC) folate is a good status indicator, and plasma total homocysteine is a good functional indicator of one-carbon metabolism. Using folate and vitamin D - two vitamins that are currently hotly debated in the public health arena - as two case studies, we discuss the complexities of using biomarkers and total intake information to assess nutrition status. These two examples also show how biomarkers and intake provide different information and how both are needed to evaluate and set public health policy. We also provide guidance on general requirements for using nutrition biomarkers and food and supplement intake information in longitudinal, population-based surveys. C1 [Pfeiffer, Christine M.; Schleicher, Rosemary L.] Ctr Dis Control & Prevent CDC, Natl Ctr Environm Hlth, Atlanta, GA USA. [Johnson, Clifford L.] CDC, Natl Ctr Hlth Stat, Hyattsville, MD USA. [Coates, Paul M.] NIH, Off Dietary Supplements, Bethesda, MD 20892 USA. RP Pfeiffer, CM (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway MS F55, Chamblee, GA 30341 USA. EM cpfeiffer@cdc.gov NR 37 TC 8 Z9 8 U1 1 U2 6 PU CO-ACTION PUBLISHING PI JARFALLA PA RIPVAGEN 7, JARFALLA, SE-175 64, SWEDEN SN 1654-6628 J9 FOOD NUTR RES JI Food Nutr. Res. PY 2012 VL 56 SU S AR 5944 DI 10.3402/fnr.v56i0.5944 PG 10 WC Food Science & Technology; Nutrition & Dietetics SC Food Science & Technology; Nutrition & Dietetics GA 119ZL UT WOS:000317138700017 ER PT J AU Frankel, MR Battaglia, MP Balluz, L Strine, T AF Frankel, Martin R. Battaglia, Michael P. Balluz, Lina Strine, Tara TI When data are not missing at random: implications for measuring health conditions in the Behavioral Risk Factor Surveillance System SO BMJ OPEN LA English DT Article ID IMPUTATION AB Objectives: To examine the effect on estimated levels of health conditions produced from large-scale surveys, when either list-wise respondent deletion or standard demographic item-level imputation is employed. To assess the degree to which further bias reduction results from the inclusion of correlated ancillary variables in the item imputation process. Design: Large cross-sectional (US level) household survey. Participants: 218 726 US adults (18 years and older) in the 2006 Behavioral Risk Factor Surveillance System Survey. This survey is the largest US telephone survey conducted by the Centers for Disease Control and Prevention. Primary and secondary outcome measures: Estimated rates of severe depression among US adults. Results: The use of list-wise respondent deletion and/or demographic imputation results in the underestimation of severe depression among adults in the USA. List-wise deletion produces underestimates of 9% (8.7% vs 9.5%). Demographic imputation produces underestimates of 7% (8.9% vs 9.5%). Both of these differences are significant at the 0.05 level. Conclusion: The use of list-wise deletion and/or demographic-only imputation may produce significant distortion in estimating national levels of certain health conditions. C1 [Frankel, Martin R.] CUNY, Baruch Coll, Dept Stat, New York, NY 10021 USA. [Battaglia, Michael P.] ABT Associates Inc, Cambridge, MA 02138 USA. [Balluz, Lina; Strine, Tara] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Frankel, MR (reprint author), CUNY, Baruch Coll, Dept Stat, New York, NY 10021 USA. EM mfrankel14@yahoo.com FU Centers for Disease Control and Prevention FX This study was supported by the Centers for Disease Control and Prevention. NR 21 TC 2 Z9 2 U1 0 U2 1 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 2044-6055 J9 BMJ OPEN JI BMJ Open PY 2012 VL 2 IS 4 AR e000696 DI 10.1136/bmjopen-2011-000696 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 091KW UT WOS:000315049300009 ER PT J AU Wyres, KL Lambertsen, LM Croucher, NJ McGee, L von Gottberg, A Linares, J Jacobs, MR Kristinsson, KG Beall, BW Klugman, KP Parkhill, J Hakenbeck, R Bentley, SD Brueggemann, AB AF Wyres, Kelly L. Lambertsen, Lotte M. Croucher, Nicholas J. McGee, Lesley von Gottberg, Anne Linares, Josefina Jacobs, Michael R. Kristinsson, Karl G. Beall, Bernard W. Klugman, Keith P. Parkhill, Julian Hakenbeck, Regine Bentley, Stephen D. Brueggemann, Angela B. TI The multidrug-resistant PMEN1 pneumococcus is a paradigm for genetic success SO GENOME BIOLOGY LA English DT Article ID PENICILLIN-BINDING PROTEINS; STREPTOCOCCUS-PNEUMONIAE STRAINS; UNITED-STATES; MOLECULAR CHARACTERIZATION; HORIZONTAL TRANSFER; SOUTH-AFRICA; CLONES; EVOLUTION; DISEASE; IDENTIFICATION AB Background: Streptococcus pneumoniae, also called the pneumococcus, is a major bacterial pathogen. Since its introduction in the 1940s, penicillin has been the primary treatment for pneumococcal diseases. Penicillin resistance rapidly increased among pneumococci over the past 30 years, and one particular multidrug-resistant clone, PMEN1, became highly prevalent globally. We studied a collection of 426 pneumococci isolated between 1937 and 2007 to better understand the evolution of penicillin resistance within this species. Results: We discovered that one of the earliest known penicillin-nonsusceptible pneumococci, recovered in 1967 from Australia, was the likely ancestor of PMEN1, since approximately 95% of coding sequences identified within its genome were highly similar to those of PMEN1. The regions of the PMEN1 genome that differed from the ancestor contained genes associated with antibiotic resistance, transmission and virulence. We also revealed that PMEN1 was uniquely promiscuous with its DNA, donating penicillin-resistance genes and sometimes many other genes associated with antibiotic resistance, virulence and cell adherence to many genotypically diverse pneumococci. In particular, we describe two strains in which up to 10% of the PMEN1 genome was acquired in multiple fragments, some as long as 32 kb, distributed around the recipient genomes. This type of directional genetic promiscuity from a single clone to numerous unrelated clones has, to our knowledge, never before been described. Conclusions: These findings suggest that PMEN1 is a paradigm of genetic success both through its epidemiology and promiscuity. These findings also challenge the existing views about horizontal gene transfer among pneumococci. C1 [Wyres, Kelly L.; Brueggemann, Angela B.] Univ Oxford, Dept Zool, Oxford OX1 3PS, England. [Lambertsen, Lotte M.] Statens Serum Inst, Dept Microbiol Surveillance & Res, DK-2300 Copenhagen S, Denmark. [Croucher, Nicholas J.; Parkhill, Julian; Bentley, Stephen D.] Wellcome Trust Sanger Inst, Pathogen Genom Team, Cambridge CB10 1SA, England. [McGee, Lesley; Beall, Bernard W.] Ctr Dis Control & Prevent, Streptococcus Lab, Atlanta, GA 30333 USA. [von Gottberg, Anne] Natl Inst Communicable Dis, Ctr Resp Dis & Meningitis, ZA-2131 Johannesburg, South Africa. [Linares, Josefina] Bellvitge Hosp CIBERes IDIBELL UB, Dept Microbiol, Barcelona 08907, Spain. [Jacobs, Michael R.] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA. [Kristinsson, Karl G.] Landspitali Univ Hosp, Dept Clin Microbiol, IS-101 Reykjavik, Iceland. [Kristinsson, Karl G.] Univ Iceland, IS-101 Reykjavik, Iceland. [Klugman, Keith P.] Rollins Sch Publ Hlth, Hubert Dept Global Hlth Epidemiol, Atlanta, GA 30322 USA. [Hakenbeck, Regine] Univ Kaiserslautern, Dept Microbiol, D-67663 Kaiserslautern, Germany. RP Brueggemann, AB (reprint author), Univ Oxford, Dept Zool, S Parks Rd, Oxford OX1 3PS, England. EM angela.brueggemann@zoo.ox.ac.uk RI Linares, Josefina/N-9450-2014; OI Brueggemann, Angela/0000-0002-2329-1934; Lambertsen, Lotte/0000-0001-6409-6337; Parkhill, Julian/0000-0002-7069-5958 NR 64 TC 15 Z9 15 U1 1 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1474-7596 J9 GENOME BIOL JI Genome Biol. PY 2012 VL 13 IS 11 AR R103 DI 10.1186/gb-2012-13-11-r103 PG 12 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA 102UC UT WOS:000315868700003 PM 23158461 ER PT B AU Eisen, RJ Gage, KL AF Eisen, Rebecca J. Gage, Kenneth L. BE Carniel, E Hinnebusch, BJ TI North American Plague Models of Enzootic Maintenance, Epizootic Spread, and Spatial and Temporal Distributions SO YERSINIA: SYSTEMS BIOLOGY AND CONTROL LA English DT Article; Book Chapter ID EARLY-PHASE TRANSMISSION; SOUTHWESTERN UNITED-STATES; FLEA-BORNE TRANSMISSION; TAILED PRAIRIE DOGS; YERSINIA-PESTIS; PNEUMONIC PLAGUE; XENOPSYLLA-CHEOPIS; CLIMATE-CHANGE; NEW-MEXICO; VECTORBORNE DISEASES AB Plague is a severe, primarily flea-borne, rodent-associated zoonosis caused by Yersinia pestis. The majority of human infections are associated with epizootic periods that are defined by rapid transmission in rodent populations. In this chapter, we highlight how modelling has been used to integrate field- and laboratory-derived data to provide insights into identifying when and where epizootics are most likely to occur, how Y. pestis is maintained during periods of apparent quiescence, what triggers a transition to the epizootic phase, and the forces that drive plague epizootics. Understanding these dynamics is critically important for targeting limited public health resources for surveillance, prevention and control, informing wildlife management decisions, and anticipating future disease trends in relation to changing climatic and land use patterns. C1 [Eisen, Rebecca J.; Gage, Kenneth L.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA. RP Eisen, RJ (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA. EM dyn2@cdc.gov; klg0@cdc.gov NR 79 TC 3 Z9 3 U1 2 U2 9 PU CAISTER ACADEMIC PRESS PI WYMONDHAM PA 32 HEWITTS LANE, WYMONDHAM NR 18 0JA, ENGLAND BN 978-1-908230-05-8 PY 2012 BP 169 EP 182 PG 14 WC Infectious Diseases SC Infectious Diseases GA BDO15 UT WOS:000314140400012 ER PT S AU Ghia, U Konangi, S Kishore, A Gressel, M Mead, K Earnest, G AF Ghia, U. Konangi, S. Kishore, A. Gressel, M. Mead, K. Earnest, G. GP ASHRAE TI Assessment of Health-Care Worker Exposure to Pandemic Flu in Hospital Rooms SO ASHRAE TRANSACTIONS 2012, VOL 118, PT 1 SE ASHRAE Transactions LA English DT Proceedings Paper CT ASHRAE Winter Conference CY 2012 CL Chicago, IL SP ASHRAE ID COUGH AB This study examines the effectiveness of a current Airborne Infection Isolation Room (AIIR) in protecting health-care workers HCWs) from airborne-infection (AI) exposure, and compares HCW AI exposures within an AIIR and a traditional patient room. We numerically simulated the air-flow patterns in the rooms, using room geometries and layout (room dimensions, bathroom dimensions and details, placement of vents and furniture), ventilation parameters (flow rates at the inlet and outlet vents, diffuser design, thermal sources, etc.), and pressurization corresponding to those measured at a local hospital A patient-cough was introduced into each simulation, and the AI dispersal was tracked in time using a multi-phase flow simulation approach. The measured data showed that ventilation rates for both rooms exceeded 12 air-changes per hour (ACH), and the AIIR was at almost 16 ACH. Thus, the AIIR met the recommended design criteria for ventilation rate and pressurization. However, the computed results revealed incomplete air mixing, and not all of the room air was changed 12 (or 16) times per hour. In fact, in some regions of the room, the air merely circulated, and did not refresh. With the main exhaust flow rate exceeding the main supply, mass flow rate conservation required a part of the deficit to be accounted for by air migration from the corridor through the gaps around the main door. Hence, the AIIR was effective in containing the "infectious aerosol" within the room. However, it showed increased exposure of the HCW to the AI pathogens, as the flow from the ceiling-mounted supply lower first encountered the patient and then the HCW almost directly on its way to the main exhaust, also located on the ceiling. The traditional patient room exhibited a similar flow path. In addition, for the traditional patient room, some cough-generated aerosol is observed very close to the gaps around the door to the corridor, indicating that the aerosol may escape to the corridor, and spread the infection beyond the room. The computational results suggest that ventilation arrangement can have an important role in better protecting the HCW from exposure to airborne infectious pathogens. C1 [Ghia, U.; Konangi, S.; Kishore, A.] Univ Cincinnati, Cincinnati, OH 45213 USA. [Gressel, M.; Mead, K.; Earnest, G.] NIOSH, Cincinnati, OH USA. RP Ghia, U (reprint author), Univ Cincinnati, Cincinnati, OH 45213 USA. FU NIOSH FX The University of Cincinnati (UC) authors gratefully acknowledge NIOSH sponsorship of this research, and the highperformance computing_resources of the Ohio Supercomputer Center, and thank Santosh Roopak Dungi, Graduate Student in Mechanical Engineering, UC, for valuable -assistance with manuscript preparation. NR 9 TC 2 Z9 2 U1 0 U2 1 PU AMER SOC HEATING, REFRIGERATING AND AIR-CONDITIONING ENGS PI ATLANTA PA 1791 TULLIE CIRCLE NE, ATLANTA, GA 30329 USA SN 0001-2505 J9 ASHRAE TRAN PY 2012 VL 118 BP 442 EP 449 PN 1 PG 8 WC Thermodynamics; Construction & Building Technology SC Thermodynamics; Construction & Building Technology GA BDC57 UT WOS:000312640000056 PM 26722128 ER PT S AU Chen, CY Ballard, RC AF Chen, Cheng-Yen Ballard, Ronald C. BE MacKenzie, CR Henrich, B TI The Molecular Diagnosis of Sexually Transmitted Genital Ulcer Disease SO DIAGNOSIS OF SEXUALLY TRANSMITTED DISEASES: METHODS AND PROTOCOLS SE Methods in Molecular Biology LA English DT Article; Book Chapter DE Polymerase chain reaction; PCR; Nucleic acid amplification test; NAAT; Genital ulcer disease; GUD; Real-time multiplex PCR; M-PCR ID IMMUNODEFICIENCY-VIRUS-INFECTION; REAL-TIME PCR; HAEMOPHILUS-DUCREYI; TREPONEMA-PALLIDUM; HIV; ETIOLOGY; SYPHILIS AB Highly sensitive and specific nucleic acid amplification tests (NAATs) have emerged as the gold standard diagnostic tests for many infectious diseases. Real-time PCR has further refined the technology of nucleic acid amplification with detection in a closed system and enabled multiplexing to simultaneously detect multiple pathogens. It is a versatile, fast, and high-throughput system for pathogen detection that has reduced the risk of PCR contamination, eliminated post-PCR manipulations, and improved the cost-effectiveness of testing. In addition, real-time PCR can be applied to self-collected noninvasive specimens. Here, we describe an in-house developed TaqMan-based real-time multiplex PCR (M-PCR) assay for the diagnosis of sexually transmitted genital ulcer disease (GUD) and discuss briefly on issues associated with validation of assay performance. C1 [Chen, Cheng-Yen; Ballard, Ronald C.] Ctr Dis Control & Prevent, Lab Reference & Res Branch, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. RP Chen, CY (reprint author), Ctr Dis Control & Prevent, Lab Reference & Res Branch, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. NR 17 TC 5 Z9 5 U1 0 U2 1 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 1064-3745 BN 978-1-61779-937-2 J9 METHODS MOL BIOL JI Methods Mol. Biol. PY 2012 VL 903 BP 103 EP 112 DI 10.1007/978-1-61779-937-2_6 D2 10.1007/978-1-61779-937-2 PG 10 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA BDJ93 UT WOS:000313569800006 PM 22782813 ER PT S AU Pau, CP Wells, SK Granade, TC AF Pau, Chou-Pong Wells, Susan K. Granade, Timothy C. BE MacKenzie, CR Henrich, B TI Protocol for the Use of a Rapid Real-Time PCR Method for the Detection of HIV-1 Proviral DNA Using Double-Stranded Primer SO DIAGNOSIS OF SEXUALLY TRANSMITTED DISEASES: METHODS AND PROTOCOLS SE Methods in Molecular Biology LA English DT Article; Book Chapter DE HIV-1 proviral DNA; Real-time PCR; Double-stranded primer; Rapid PCR; Nucleic acid testing AB This chapter describes a real-time PCR method for the detection of HIV-1 proviral DNA in whole blood samples using a novel double-stranded primer system. The assay utilizes a simple commercially available DNA extraction method and a rapid and easy-to-perform real-time PCR protocol to consistently detect a minimum of four copies of HIV-1 group M proviral DNA in as little as 90 min after sample (whole blood) collection. Co-amplification of the human RNase P gene serves as an internal control to monitor the efficiency of both the DNA extraction and amplification. Once the assay is validated properly, it may be suitable as an alternative confirmation test for HIV-1 infections in a variety of HIV testing venues including the mother-to-child transmission testing sites, clinics, and diagnostic testing centers. C1 [Pau, Chou-Pong; Wells, Susan K.; Granade, Timothy C.] Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. RP Pau, CP (reprint author), Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. NR 6 TC 1 Z9 1 U1 0 U2 1 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 1064-3745 BN 978-1-61779-937-2 J9 METHODS MOL BIOL JI Methods Mol. Biol. PY 2012 VL 903 BP 263 EP 271 DI 10.1007/978-1-61779-937-2_17 D2 10.1007/978-1-61779-937-2 PG 9 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA BDJ93 UT WOS:000313569800017 PM 22782824 ER PT S AU Chen, CY Pillay, A AF Chen, Cheng-Yen Pillay, Allan BE MacKenzie, CR Henrich, B TI Protocol for the Detection of Treponema pallidum in Paraffin-Embedded Specimens SO DIAGNOSIS OF SEXUALLY TRANSMITTED DISEASES: METHODS AND PROTOCOLS SE Methods in Molecular Biology LA English DT Article; Book Chapter DE Polymerase chain reaction; PCR; Real-time PCR; Treponema pallidum; FFPE; Paraffin-embedded specimen ID REAL-TIME PCR; POLYMERASE-CHAIN-REACTION; SECONDARY SYPHILIS; I GENE; DNA; DIAGNOSIS; NEUROSYPHILIS; AMPLIFICATION; DESIGN; TESTS AB Formalin-fixed paraffin-embedded (FFPE) tissue blocks are routinely used for histopathological examination and are also useful for specific pathogen detection by polymerase chain reaction (PCR). FFPE tissue is stable at ambient temperature for an extended period of time and relatively easy to transport compared to fresh tissue, which has to be processed or frozen immediately. In addition, archival material is an invaluable source for retrospective molecular and clinical investigation. This chapter describes detailed procedures for nucleic acid extraction and PCR detection of Treponema pallidum using FFPE tissue. C1 [Chen, Cheng-Yen; Pillay, Allan] Ctr Dis Control & Prevent, Lab Reference & Res Branch, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. RP Chen, CY (reprint author), Ctr Dis Control & Prevent, Lab Reference & Res Branch, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. NR 18 TC 1 Z9 1 U1 1 U2 1 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 1064-3745 BN 978-1-61779-937-2 J9 METHODS MOL BIOL JI Methods Mol. Biol. PY 2012 VL 903 BP 295 EP 306 DI 10.1007/978-1-61779-937-2_20 D2 10.1007/978-1-61779-937-2 PG 12 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA BDJ93 UT WOS:000313569800020 PM 22782827 ER PT J AU Park, S Sherry, B Foti, K Blanck, HM AF Park, Sohyun Sherry, Bettylou Foti, Kathryn Blanck, Heidi M. TI Self-Reported Academic Grades and Other Correlates of Sugar-Sweetened Soda Intake among US Adolescents SO JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS LA English DT Article ID SOFT DRINK CONSUMPTION; BEVERAGE CONSUMPTION; SCHOOL-STUDENTS; UNITED-STATES; PHYSICAL-ACTIVITY; CHILDREN; YOUTH; BEHAVIORS; DIETARY; RISK AB High consumption of sugar-sweetened drinks has been associated with obesity and other adverse health consequences. This cross-sectional study examined the association of demographic characteristics, weight status, self-reported academic grades, and behavioral factors with sugar-sweetened soda intake among a nationally representative sample of US high school students. Analysis was based on the 2009 national Youth Risk Behavior Survey and included 16,188 students in grades 9 through 12. The main outcome measure was daily sugar-sweetened soda intake (eg, drank a can, bottle, or glass of soda [excluding diet soda] at least one time per day during the 7 days before the survey). Nationally, 29.2% of students reported drinking sugar-sweetened soda at least one time per day. Logistic regression analyses showed factors significantly associated with sugar-sweetened soda intake at least one time per day included male sex (adjusted odds ratio [OR]=1.47), Hispanic ethnicity (vs whites; OR=0.81), earning mostly B, C, and D/F grades (vs mostly As; OR=1.26, 1.66, and 2.19, respectively), eating vegetables fewer than three times per day (OR=0.72), trying to lose weight (OR=0.72), sleeping <8 hours (OR=1.18), watching television >2 hours/day (OR=1.71), playing video or computer games or using a computer for other than school work >2 hours/day (OR=1.53), being physically active at least 60 minutes/day on <5 days during the 7 days before the survey (OR=1.19), and current cigarette use (OR=2.01). The significant associations with poor self-reported academic grades, inadequate sleep, sedentary behaviors, and cigarette smoking suggest research should examine why soda consumption is associated with these behaviors to inform the design of future nutrition interventions. J Acad Nutr Diet. 2012;112:125-131. C1 [Park, Sohyun; Sherry, Bettylou; Blanck, Heidi M.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Foti, Kathryn] Ctr Dis Control & Prevent, Div Adolescent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Foti, Kathryn] Ctr Dis Control & Prevent, Sch Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Park, S (reprint author), Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,Mailstop K26, Atlanta, GA 30341 USA. EM spark3@cdc.gov NR 42 TC 28 Z9 29 U1 1 U2 18 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 2212-2672 J9 J ACAD NUTR DIET JI J. Acad. Nutr. Diet. PD JAN PY 2012 VL 112 IS 1 BP 125 EP 131 DI 10.1016/j.jada.2011.08.045 PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 083CH UT WOS:000314439800016 PM 22709642 ER PT J AU Parola, P Paddock, CD AF Parola, Philippe Paddock, Christopher D. TI Untitled SO TICKS AND TICK-BORNE DISEASES LA English DT Editorial Material C1 [Parola, Philippe] Aix Marseille Univ, WHO Collaborat Ctr Rickettsioses & Other Arthropo, CNRS 7278, Fac Med,URMITE,UM63,IRD 198,Inserm 1095, F-13385 Marseille 5, France. [Paddock, Christopher D.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Parola, P (reprint author), Aix Marseille Univ, WHO Collaborat Ctr Rickettsioses & Other Arthropo, CNRS 7278, Fac Med,URMITE,UM63,IRD 198,Inserm 1095, 27 Bd Jean Moulin, F-13385 Marseille 5, France. EM philippe.parola@univ-amu.fr NR 0 TC 0 Z9 0 U1 0 U2 3 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 1877-959X J9 TICKS TICK-BORNE DIS JI Ticks Tick-Borne Dis. PY 2012 VL 3 IS 5-6 BP 269 EP 269 DI 10.1016/j.ttbdis.2012.10.036 PG 1 WC Infectious Diseases; Microbiology; Parasitology SC Infectious Diseases; Microbiology; Parasitology GA 078EK UT WOS:000314081000001 PM 23182547 ER PT J AU Hajjeh, RA Talaat, M Jumaan, AO AF Hajjeh, Rana A. Talaat, Maha Jumaan, Aisha O. BE Jabbour, S Giacaman, R Khawaja, M Nuwayhid, I TI Infectious Diseases: The Unfinished Agenda and Future Needs SO PUBLIC HEALTH IN THE ARABWORLD LA English DT Article; Book Chapter ID EASTERN MEDITERRANEAN REGION; HOSPITAL-ACQUIRED INFECTION; ACUTE FEBRILE ILLNESS; INTENSIVE-CARE-UNIT; HEPATITIS-C VIRUS; RISK-FACTORS; HEALTH-CARE; ANTIMICROBIAL RESISTANCE; HIV-INFECTION; SAUDI-ARABIA AB In the twenty-first century, infectious diseases continue to be a major public health problem in most countries across the national income spectrum. While the Arab world has seen substantial improvement of life expectancy and reduction of infant and child mortality since the 1950s, infectious diseases still account for a large proportion of the total disease burden. The WHO report on the global disease burden (WHO 2008a) estimates that almost one third of all deaths in the Eastern Mediterranean region is due to infectious diseases (1,315,000 out of 4,306,000 deaths or 30%); the most common infectious diseases causing deaths included respiratory infections, followed by diarrheal diseases, tuberculosis, and childhood vaccine preventable diseases. Over the past two decades, the Arab world has witnessed the emergence or re-emergence of various infectious diseases, including some that were thought to be almost eliminated. We review here a selected set of infectious diseases of particular public health importance, such as diseases of epidemic potential, vaccine preventable diseases, and health care-related infections, and the factors associated with their persistence. We explore infection control as well as surveillance programs and conclude with next steps for infectious disease control and prevention. C1 [Hajjeh, Rana A.] Ctr Dis Control & Prevent, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Talaat, Maha] US Naval Med Res Unit 3, Infect Control Unit, Global Dis Detect & Response Program, Cairo, Egypt. [Jumaan, Aisha O.] Ctr Dis Control & Prevent, Div Publ Hlth Syst & Workforce Dev, Ctr Global Hlth, Atlanta, GA USA. RP Hajjeh, RA (reprint author), Ctr Dis Control & Prevent, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. NR 63 TC 2 Z9 2 U1 1 U2 2 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA THE PITT BUILDING, TRUMPINGTON ST, CAMBRIDGE CB2 1RP, CAMBS, ENGLAND BN 978-0-521-51674-7 PY 2012 BP 136 EP 148 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA BDB55 UT WOS:000312485700013 ER PT J AU Sibai, AM Tohme, RA Yamout, R Yount, KM Kronfol, NM AF Sibai, Abla Mehio Tohme, Rania A. Yamout, Rouham Yount, Kathryn M. Kronfol, Nabil M. BE Jabbour, S Giacaman, R Khawaja, M Nuwayhid, I TI The Older Persons: From Veneration to Vulnerability? SO PUBLIC HEALTH IN THE ARABWORLD LA English DT Article; Book Chapter ID LIVING ARRANGEMENTS; RISK-FACTORS; HEALTH; LEBANON; POPULATION; PREVALENCE; RESOURCES; OVERWEIGHT; COUNTRIES; OBESITY C1 [Sibai, Abla Mehio; Yamout, Rouham] Amer Univ Beirut, Fac Hlth Sci, Beirut, Lebanon. [Sibai, Abla Mehio] Ctr Studies Aging, Beirut, Lebanon. [Tohme, Rania A.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. [Yount, Kathryn M.] Emory Univ, Hubert Dept Global Hlth, Atlanta, GA 30322 USA. [Yount, Kathryn M.] Emory Univ, Dept Sociol, Atlanta, GA 30322 USA. [Kronfol, Nabil M.] Lebanese HealthCare Management Assoc, Beirut, Lebanon. RP Sibai, AM (reprint author), Amer Univ Beirut, Fac Hlth Sci, Beirut, Lebanon. NR 63 TC 5 Z9 5 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA THE PITT BUILDING, TRUMPINGTON ST, CAMBRIDGE CB2 1RP, CAMBS, ENGLAND BN 978-0-521-51674-7 PY 2012 BP 264 EP 275 PG 12 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA BDB55 UT WOS:000312485700022 ER PT J AU Piesman, J Hojgaard, A AF Piesman, Joseph Hojgaard, Andrias TI Protective value of prophylactic antibiotic treatment of tick bite for Lyme disease prevention: An animal model SO TICKS AND TICK-BORNE DISEASES LA English DT Article; Proceedings Paper CT 7th Conference on Ticks and Tick-Borne Pathogens CY AUG 28-SEP 02, 2011 CL Zaragoza, SPAIN DE Lyme disease; Ticks; Antibiotic; Prophylaxis; Ixodes scapularis; Borrelia ID IXODES-SCAPULARIS ACARI; BORRELIA-BURGDORFERI; DOXYCYCLINE HYCLATE; IXODIDAE NYMPHS; MURINE MODEL; VACCINE; FORMULATION; INFECTION; ABUNDANCE; MICE AB Clinical studies have demonstrated that prophylactic antibiotic treatment of tick bites by Ixodes scapularis in Lyme disease hyperendemic regions in the northeastern United States can be effective in preventing infection with Borrelia burgdorferi sensu stricto, the Lyme. disease spirochete. A large clinical trial in Westchester County, NY (USA), demonstrated that treatment of tick bite with 200 mg of oral doxycycline was 87% effective in preventing Lyme disease in tick-bite victims (Nadelman, R.B., Nowakowski, J., Fish, D., Falco, R.C., Freeman. K., McKenna, D., Welch, P., Marcus, R., Aguero-Rosenfeld, ME., Dennis, D.T., Wormser, G.P., 2001. Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite. N. Engl. J. Med. 345, 79-84.). Although this excellent clinical trial provided much needed information, the authors enrolled subjects if the tick bite occurred within 3 days of their clinical visit, but did not analyze the data based on the exact time between tick removal and delivery of prophylaxis. An animal model allows for controlled experiments designed to determine the point in time after tick bite when delivery of oral antibiotics would be too late to prevent infection with B. burgdorferi. Accordingly, we developed a tick-bite prophylaxis model in mice that gave a level of prophylactic protection similar to what had been observed in clinical trials and then varied the time post tick bite of antibiotic delivery. We found that two treatments of doxycycline delivered by oral gavage to mice on the day of removal of a single potentially infectious nymphal I. scapularis protected 74% of test mice compared to controls. When treatment was delayed until 24h after tick removal, only 47% of mice were protected; prophylactic treatment was totally ineffective when delivered >= 2 days after tick removal. Although the dynamics of antibiotic treatment in mice may differ from humans, and translation of animal studies to patient management must be approached with caution, we believe our results emphasize the point that antibiotic prophylactic treatment of tick bite to prevent Lyme disease is more likely to be efficacious if delivered promptly after potentially infectious ticks are removed from patients. There is only a very narrow window for prophylactic treatment to be effective post tick removal. Published by Elsevier GmbH. C1 [Piesman, Joseph; Hojgaard, Andrias] Ctr Dis Control & Prevent, Bacterial Dis Branch, Div Vector Borne Dis, Ft Collins, CO 80521 USA. RP Hojgaard, A (reprint author), Ctr Dis Control & Prevent, Bacterial Dis Branch, Div Vector Borne Dis, 3150 Rampart Rd, Ft Collins, CO 80521 USA. EM fth3@cdc.gov NR 35 TC 7 Z9 7 U1 2 U2 8 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 1877-959X J9 TICKS TICK-BORNE DIS JI Ticks Tick-Borne Dis. PY 2012 VL 3 IS 3 SI SI BP 193 EP 196 DI 10.1016/j.ttbdis.2012.01.001 PG 4 WC Infectious Diseases; Microbiology; Parasitology SC Infectious Diseases; Microbiology; Parasitology GA 031PT UT WOS:000310655100011 PM 22421585 ER PT J AU Bowen, MS Kolor, K Dotson, WD Ned, RM Khoury, MJ AF Bowen, M. S. Kolor, K. Dotson, W. D. Ned, R. M. Khoury, M. J. TI Public Health Action in Genomics Is Now Needed beyond Newborn Screening SO PUBLIC HEALTH GENOMICS LA English DT Review DE Cascade screening; Evidenced-based recommendations; Health impact; Tier 1 genomics applications ID GENETIC TESTING STRATEGIES; LYNCH SYNDROME; COST-EFFECTIVENESS; COLORECTAL-CANCER; DISEASE; BRCA; INDIVIDUALS; PREVENTION; MUTATION; BREAST AB For decades, newborn screening was the only public health program in the US focused on reducing morbidity, mortality and disability in people affected by genetic conditions. The landscape has changed, however, as evidence-based recommendations are now available for several other genomic applications that can save lives now in the US. Many more such applications are expected to emerge in the next decade. An action plan, based on evidence, provides the impetus for a new paradigm for public health practice in genomics across the lifespan using established multilevel processes as a guide. These include policy interventions, education, clinical interventions, and surveillance. Applying what we know today in hereditary breast/ovarian cancer, Lynch syndrome and familial hypercholesterolemia has the potential to affect thousands of people in the US population every year. Enhanced partnerships between genetic and nongenetic providers of clinical medicine and public health are needed to overcome the challenges for implementing genomic medicine applications both now and in the future. Copyright (C) 2012 S. Karger AG, Basel C1 [Bowen, M. S.; Kolor, K.; Dotson, W. D.; Ned, R. M.; Khoury, M. J.] Ctr Dis Control & Prevent, Dept Hlth & Human Serv, Atlanta, GA 30333 USA. RP Bowen, MS (reprint author), Ctr Dis Control & Prevent, Dept Hlth & Human Serv, 1600 Clifton Rd,MS 61, Atlanta, GA 30333 USA. EM msb4@cdc.gov OI Dotson, William David/0000-0002-9606-6594 FU Intramural CDC HHS [CC999999] NR 29 TC 18 Z9 18 U1 1 U2 5 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1662-4246 J9 PUBLIC HEALTH GENOM JI Pub. Health Genomics PY 2012 VL 15 IS 6 BP 327 EP 334 DI 10.1159/000341889 PG 8 WC Genetics & Heredity; Public, Environmental & Occupational Health SC Genetics & Heredity; Public, Environmental & Occupational Health GA 046PZ UT WOS:000311778200003 PM 22986915 ER PT S AU Morata, TC Johnson, AC AF Morata, Thais C. Johnson, Ann-Christin BE LePrell, CG Henderson, D Fay, RR Popper, AN TI Effects of Exposure to Chemicals on Noise-Induced Hearing Loss SO NOISE-INDUCED HEARING LOSS: SCIENTIFIC ADVANCES SE Springer Handbook of Auditory Research LA English DT Article; Book Chapter ID AUDITORY-EVOKED-POTENTIALS; OUTER HAIR-CELLS; CARBON-MONOXIDE; LEAD-EXPOSURE; INDUCED OTOTOXICITY; FREQUENCY HEARING; GUINEA-PIG; OCCUPATIONAL-EXPOSURE; OTOACOUSTIC EMISSIONS; SOLVENT OTOTOXICITY C1 [Morata, Thais C.] NIOSH, Cincinnati, OH 45226 USA. [Johnson, Ann-Christin] Karolinska Inst, S-14183 Stockholm, Sweden. RP Morata, TC (reprint author), NIOSH, 4676 Columbia Pkwy, Cincinnati, OH 45226 USA. EM tmorata@cdc.gov; ann-christin.johnson@ki.se NR 114 TC 2 Z9 2 U1 0 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 0947-2657 BN 978-1-4419-9523-0 J9 SPRINGER HANDB AUDIT JI Springer Handb. Audit. Res. PY 2012 VL 40 BP 223 EP 254 DI 10.1007/978-1-4419-9523-0_11 D2 10.1007/978-1-4419-9523-0 PG 32 WC Audiology & Speech-Language Pathology SC Audiology & Speech-Language Pathology GA BZJ00 UT WOS:000301748500011 ER PT J AU Patel, P Bush, T Overton, T Baker, J Hammer, J Kojic, E Conley, L Henry, K Brooks, JT AF Patel, Pragna Bush, Tim Overton, Turner Baker, Jason Hammer, John Kojic, Erna Conley, Lois Henry, Keith Brooks, John T. CA SUN Study Investigators TI Effect of abacavir on acute changes in biomarkers associated with cardiovascular dysfunction SO ANTIVIRAL THERAPY LA English DT Article ID COMBINATION ANTIRETROVIRAL THERAPY; HIV-INFECTED PATIENTS; REVERSE-TRANSCRIPTASE INHIBITORS; MYOCARDIAL-INFARCTION; NATURAL-HISTORY; SUPPRESSED HIV; RISK; COHORT; AIDS; ERA AB Background: This study examined the effect of abacavir on acute changes in biomarkers associated with cardiovascular dysfunction. Methods: Among the Study to Understand the Natural History of HIV/AIDS in the Era of Effective therapy (SUN) participants, we identified 25 individuals (cases) who were HLA-B5701-negative and who had >= 2 weeks without abacavir exposure at one visit and >= 2 weeks with abacavir exposure at the consecutive visit while maintaining viral suppression. We identified 43 individuals (controls) similarly unexposed and exposed to tenofovir. We assessed concentrations of prothrombin fragment F(1+2), D-dimer, high-sensitivity C-reactive protein, interleukin-8, intercellular adhesion molecule-1, vascular adhesion molecule-1, E-selectin, P-selectin, serum amyloid A and serum amyloid P. We examined the median percentage change of these biomarkers from the unexposed to exposed state among cases and controls compared with the expected assay variability using a sign test, and compared changes among cases with controls using the Wilcoxon rank-sum test. Results: Baseline characteristics were similar between cases and controls: median age 45 versus 46 years, 80% versus 81% male, 64% versus 63% non-Hispanic White and median CD4(+) T-cell count 538 versus 601 cells/mm(3), respectively. Mean exposure times were 65 and 15 weeks for abacavir and tenofovir, respectively. We observed no significant changes in biomarkers from the unexposed to exposed state among cases or controls compared with the expected assay variability. We found that no biomarkers were significantly increased among cases compared with controls; however, prothrombin fragment F(1+2) was significantly lower among controls (P=0.035). Conclusions: In virologically suppressed contemporary HIV-infected patients, abacavir exposure was not associated with increases in biomarkers associated with increased cardiovascular risk. C1 [Patel, Pragna; Bush, Tim; Conley, Lois; Brooks, John T.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. [Overton, Turner] Washington Univ, Sch Med, St Louis, MO USA. [Baker, Jason; Henry, Keith] Univ Minnesota, Hennepin Cty Med Ctr, Minneapolis, MN 55415 USA. [Hammer, John] Denver Infect Dis Consultants, Denver, CO USA. [Kojic, Erna] Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USA. RP Patel, P (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. EM plp3@cdc.gov FU Centers for Disease Control and Prevention [200-2002-00610, 200-2002-00611, 200-2002-00612, 200-2002-00613, 200-2007-23633, 200-2007-23634, 200-2007-23635, 200-2007-23636]; National Institute of Health [NIAID Y1-AI-9464-01]; National Institute of Health; NIAID [Y1-AI-9464-01]; Gilead; GSK/ViiV; American Heart Association; National Institutes of Health FX Financial support was provided by Centers for Disease Control and Prevention contract numbers 200-2002-00610, 200-2002-00611, 200-2002-00612, 200-2002-00613, 200-2007-23633, 200-2007-23634, 200-2007-23635 and 200-2007-23636 and National Institute of Health interagency agreement NIAID Y1-AI-9464-01.; The authors would like to express our appreciation to all the SUN Study participants. We would also like to thank Carl Dieffenbach and Susan Brobst at the National Institute of Health for their support of this work (funded in part by NIAID Y1-AI-9464-01).; TO has served as a consultant or on an advisory board for the following companies: Gilead, Bristol-Myers Squibb, GlaxoSmithKline, Tibotec, Merck and Monogram Sciences. JB receives research funding from Gilead, GSK/ViiV, American Heart Association and National Institutes of Health. KH has served as a consultant or on an advisory board for the following companies: Gilead, GSK/ViiV and Tibotec. All other authors declare no competing interests. The findings and conclusions from this review are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 24 TC 7 Z9 7 U1 1 U2 3 PU INT MEDICAL PRESS LTD PI LONDON PA 2-4 IDOL LANE, LONDON EC3R 5DD, ENGLAND SN 1359-6535 J9 ANTIVIR THER JI Antivir. Ther. PY 2012 VL 17 IS 4 BP 755 EP 761 DI 10.3851/IMP2020 PG 7 WC Infectious Diseases; Pharmacology & Pharmacy; Virology SC Infectious Diseases; Pharmacology & Pharmacy; Virology GA 036LK UT WOS:000311027200017 PM 22301072 ER PT J AU Costantini, VP Whitaker, T Barclay, L Lee, D McBrayer, TR Schinazi, RF Vinje, J AF Costantini, Veronica P. Whitaker, Tony Barclay, Leslie Lee, David McBrayer, Tamara R. Schinazi, Raymond F. Vinje, Jan TI Antiviral activity of nucleoside analogues against norovirus SO ANTIVIRAL THERAPY LA English DT Article ID DEPENDENT RNA-POLYMERASES; NORWALK VIRUS; MURINE NOROVIRUS; POTENT INHIBITOR; GII.4 NOROVIRUS; INFECTED-CELLS; UNITED-STATES; REPLICATION; GASTROENTERITIS; 2'-C-METHYLCYTIDINE AB Background: Norovirus (NoV) is the leading cause of epidemic gastroenteritis worldwide. The lack of a cell culture has significantly hampered the development of effective therapies against human NoV. Clinically approved nucleoside and non-nucleoside analogues have been used successfully against RNA viruses. Methods: In this study, we evaluated the efficacy of four nucleoside analogues (2 '-C-MeC, 2 '-F-2 '-C-MeC, beta-DN(4)-hydroxycytidine [NHC] and lamivudine) on Norwalk virus (NV) RNA levels and protein expression in NV repliconharbouring cells (HG23 cells), and their efficacy in blocking murine norovirus (MNV) replication in RAW 264.7 cells. Results: 2 '-C-MeC and 2 '-F-2 '-C-MeC reduced MNV RNA levels and infectivity in RAW 264.7 cells in a concentration- and time-dependent manner. The median effective concentrations (EC50) of 2 '-C-MeC and 2 '-F-2 '-C-MeC were 6.9 mu M and 12.7 mu M, respectively. 2 '-C-MeC, 2 '-F-2 '-C-MeC and NHC reduced NV RNA levels and protein expression in HG23 cells. For the NV replicon, the EC50 of 2'-C-MeC (1.3 mu M) was comparable to the antiviral activity of NHC (1.5 mu M) and twofold more potent than 2 '-F-2 '-C-MeC (3.2 mu M). The combination of 2 '-C-MeC/ ribavirin resulted in modest synergistic activity, whereas NHC/ribavirin was antagonistic for NV replication in HG23 cells. Conclusions: The antiviral activity of 2'-C-MeC against strains of two different NoV genogroups and the low EC50 suggest that this nucleoside analogue may be effective against the more prevalent GII NoVs. In the absence of a vaccine, antiviral agents could be an effective intervention to control the spread of human NoV in populations at a high risk for NoV disease. C1 [Costantini, Veronica P.; Barclay, Leslie; Lee, David; Vinje, Jan] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Atlanta, GA 30329 USA. [Whitaker, Tony; McBrayer, Tamara R.] RFS Pharma LLC, Tucker, GA USA. [Schinazi, Raymond F.] Emory Univ, Sch Med, Dept Pediat, Ctr AIDS Res,Lab Biochem Pharmacol, Decatur, GA 30033 USA. [Schinazi, Raymond F.] Vet Affairs Med Ctr, Decatur, GA 30033 USA. RP Costantini, VP (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Atlanta, GA 30329 USA. EM vcostantini@cdc.gov RI Schinazi, Raymond/B-6777-2017; OI Vinje, Jan/0000-0002-1530-3675; Costantini, Veronica/0000-0002-1532-4345 FU CDC Foundation; Atlanta Department of Veterans Affairs; CFAR [2P30-AI-050409] FX This study was partially supported by a grant from CDC Foundation. RFS's salary is partly supported by the Atlanta Department of Veterans Affairs and by CFAR grant 2P30-AI-050409. NR 47 TC 15 Z9 15 U1 0 U2 10 PU INT MEDICAL PRESS LTD PI LONDON PA 2-4 IDOL LANE, LONDON EC3R 5DD, ENGLAND SN 1359-6535 J9 ANTIVIR THER JI Antivir. Ther. PY 2012 VL 17 IS 6 BP 981 EP 991 DI 10.3851/IMP2229 PG 11 WC Infectious Diseases; Pharmacology & Pharmacy; Virology SC Infectious Diseases; Pharmacology & Pharmacy; Virology GA 037CZ UT WOS:000311080700005 PM 22910194 ER PT J AU Verbeek, JH Kateman, E Morata, TC Dreschler, WA Mischke, C AF Verbeek, Jos H. Kateman, Erik Morata, Thais C. Dreschler, Wouter A. Mischke, Christina TI Interventions to prevent occupational noise-induced hearing loss SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS LA English DT Review DE Hearing Loss, Noise-Induced [prevention & control]; Noise, Occupational [adverse effects; prevention & control]; Occupational Diseases [prevention & control]; Randomized Controlled Trials as Topic; Humans ID STANDARD LABORATORY PROTOCOL; CONSERVATION PROGRAM; CONSTRUCTION WORKERS; FIELD ATTENUATION; PROTECTOR ATTENUATION; OTOACOUSTIC EMISSIONS; RANDOMIZED-TRIALS; GLOBAL BURDEN; UNITED-STATES; EXPOSURE AB Background Millions of workers worldwide are exposed to noise levels that increase their risk of hearing impairment. Little is known about the effectiveness of hearing loss prevention interventions. Objectives To assess the effectiveness of non-pharmaceutical interventions for preventing occupational noise exposure or occupational hearing loss compared to no intervention or alternative interventions. Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL); PubMed; EMBASE; CINAHL; Web of Science; BIOSIS Previews; Cambridge Scientific Abstracts; and OSH update to 25 January 2012. Selection criteria We included randomised controlled trials (RCT), controlled before-after studies (CBA) and interrupted time-series (ITS) of non-clinical hearing loss prevention interventions under field conditions among workers exposed to noise. Data collection and analysis Two authors independently assessed study eligibility and risk of bias and extracted data. Main results We included 25 studies. We found no controlled studies on engineering controls for noise exposure but one study evaluated legislation to reduce noise exposure in a 12-year time-series analysis. Eight studies with 3,430 participants evaluated immediate and long-term effects of personal hearing protection devices (HPDs) and sixteen studies with 82,794 participants evaluated short and long-term effects of hearing loss prevention programmes (HLPPs). The overall quality of studies was low to very low. The one ITS study that evaluated the effect of new legislation in reducing noise exposure found that the median noise level decreased by 27.7 dB(A) (95% confidence interval (CI) -36.1 to -19.3 dB) immediately after the implementation of stricter legislation and that this was associated with a favourable downward trend in time of -2.1 dB per year (95% CI -4.9 to 0.7). Hearing protection devices attenuated noise with about 20 dB(A) with variation among brands and types but for ear plugs these findings depended almost completely on proper instruction of insertion. Noise attenuation ratings of hearing protection under field conditions were consistently lower than the ratings provided by the manufacturers. One cluster-RCT compared a three-year information campaign as part of a hearing loss prevention programme for agricultural students to audiometry only with three and 16-year follow-up but there were no significant differences in hearing loss. Another study compared a HLPP, which provided regular personal noise exposure information, to a programme without this information in a CBA design. Exposure information was associated with a favourable but non-significant reduction of the rate of hearing loss of -0.82 dB per year (95% CI -1.86 to 0.22). Another cluster-RCT evaluated the effect of extensive on-site training sessions and the use of personal noise-level indicators versus information only on noise levels but did not find a significant difference after four months follow-up (Mean Difference (MD) -0.30 dB(A) (95% CI -3.95 to 3.35). There was very low quality evidence in four very long-term studies, that better use of HPDs as part of a HLPP decreased the risk of hearing loss compared to less well used hearing protection in HLPPs. Other aspects of the HLPP such as training and education of workers or engineering controls did not show a similar effect. In four long-term studies, workers in a HLPP still had a 0.5 dB greater hearing loss at 4 kHz than workers that were not exposed to noise (95% CI -0.5 to 1.7) which is about the level of hearing loss caused by exposure to 85 dB(A). In addition, two other studies showed substantial risk of hearing loss in spite of the protection of a HLPP compared to non-exposed workers. Authors' conclusions There is low quality evidence that implementation of stricter legislation can reduce noise levels in workplaces. Even though case studies show that substantial reductions in noise levels in the workplace can be achieved, there are no controlled studies of the effectiveness of such measures. The effectiveness of hearing protection devices depends on training and their proper use. There is very low quality evidence that the better use of hearing protection devices as part of HLPPs reduces the risk of hearing loss, whereas for other programme components of HLPPs we did not find such an effect. Better implementation and reinforcement of HLPPs is needed. Better evaluations of technical interventions and long-term effects are needed. C1 [Verbeek, Jos H.; Mischke, Christina] Finnish Inst Occupat Hlth, Cochrane Occupat Safety & Hlth Review Grp, Kuopio 70101, Finland. [Kateman, Erik] Arbounie, Ctr Expertise Hearing & Noise Problems, NL-7007 HC Doetinchem, Netherlands. [Morata, Thais C.] NIOSH, Cincinnati, OH 45226 USA. [Dreschler, Wouter A.] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands. RP Verbeek, JH (reprint author), Finnish Inst Occupat Hlth, Cochrane Occupat Safety & Hlth Review Grp, POB 310, Kuopio 70101, Finland. EM jos.verbeek@ttl.fi OI Verbeek, Jos/0000-0002-6537-6100 FU Dutch Ministry of Social Affairs and Employment as part of the KIS programme, Netherlands; Finnish Ministry of Social Affairs and Health, Finland; The Cochrane Occupational Safety and Health Review Group, Finland; Stichting Arbouw, Netherlands; Dutch Ministry of Social Affairs and Employment FX External sources; Dutch Ministry of Social Affairs and Employment as part of the KIS programme, Netherlands.; The second author received a grant.; Finnish Ministry of Social Affairs and Health, Finland.; Supported the Cochrane Occupational Safety and Health Review Group financially.; The Cochrane Occupational Safety and Health Review Group, Finland.; Provided support in kind.; Stichting Arbouw, Netherlands.; Provided EURO5000 for the 2012 update of the review; We would like to thank the Dutch Ministry of Social Affairs and Employment for the grant received to complete this review. In addition, we would like to thank Jani Ruotsalainen from the Cochrane Occupational Safety and Health Review Group and Jenny Bellorini from the Cochrane ENT Disorders Review Group for their support. We also thank Bas Sorgdrager who contributed to an earlier version of this review. NR 123 TC 4 Z9 4 U1 3 U2 44 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1469-493X J9 COCHRANE DB SYST REV JI Cochrane Database Syst Rev. PY 2012 IS 10 AR CD006396 DI 10.1002/14651858.CD006396.pub3 PG 112 WC Medicine, General & Internal SC General & Internal Medicine GA 023EY UT WOS:000310016900002 ER PT J AU Rohan, EA AF Rohan, Elizabeth A. TI Removing the Stress from Selecting Instruments: Arming Social Workers to Take Leadership in Routine Distress Screening Implementation SO JOURNAL OF PSYCHOSOCIAL ONCOLOGY LA English DT Article DE distress screening implementation; distress screening in cancer patients; oncology social workers; social work leadership role ID CANCER-PATIENTS; PSYCHOLOGIC DISTRESS; ELDERLY-PATIENTS; INTERVENTIONS; THERMOMETER; DEPRESSION; ONCOLOGY; VALIDATION; DISORDERS; THERAPY AB Quality cancer care requires identifying and addressing the psychosocial needs of cancer patients. Oncology social workers have long been on the forefront of this endeavor. Although there has been longstanding interest in screening cancer patients for distress, it has recently been included as a quality of care metric in institutions accredited by the American College of Surgeons. Implementing routine screening for distress in oncology settings requires thoughtful planning, including assessing various screening instruments and considering a host of variables within each practice setting. Oncology social workers are best positioned to provide leadership in operationalizing this mandate and to lead their team in the choice of a distress measure for compliance with the screening guideline. This article highlights the most popular distress screening measures used in oncology and their psychometric properties. C1 Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA 30341 USA. RP Rohan, EA (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, 4770 Buford Hwy,MS K-57, Atlanta, GA 30341 USA. EM ERohan@cdc.gov FU Intramural CDC HHS [CC999999] NR 44 TC 7 Z9 7 U1 0 U2 8 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0734-7332 J9 J PSYCHOSOC ONCOL JI J. Psychosoc. Oncol. PY 2012 VL 30 IS 6 SI SI BP 667 EP 678 DI 10.1080/07347332.2012.721487 PG 12 WC Psychology, Social SC Psychology GA 030TT UT WOS:000310593700005 PM 23101550 ER PT J AU Menendez, CC Amick, BC Jenkins, M Caroom, C Robertson, M Gerr, F Moore, JS Harrist, RB Katz, JN AF Menendez, Cammie Chaumont Amick, Benjamin C., III Jenkins, Mark Caroom, Cyrus Robertson, Michelle Gerr, Fred Moore, J. Steven Harrist, Ronald B. Katz, Jeffrey N. TI A validation study comparing two self-reported upper extremity symptom surveys with clinical examinations for upper extremity musculoskeletal disorders SO WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION LA English DT Article DE Computing-related; graduate students; Youden's J; sensitivity; specificity ID CARPAL-TUNNEL-SYNDROME; RANDOMIZED CONTROLLED-TRIAL; COMPUTER USERS; RISK-FACTORS; WORK; ELBOW; NECK; CLASSIFICATION; PREDICTORS; OPERATORS AB Objective: Evaluate the validity of two self-report symptoms surveys with two disorder classification protocols. Participants: 100 graduate students at a private school in the Southwest United States. Methods: Study participants completed two self-report upper extremity musculoskeletal symptoms surveys: a nine item 10 cm Visual Analogue Scale (VAS) and a nine item Likert categorical scale anchored from "None" to "Very severe". Clinical examinations were administered using two musculoskeletal disorder classification protocols. Results: For the nine body regions, concordance between the two self-report symptoms scales ranged from 0.49-0.75. Overall there was greater than 80% agreement for the two disorder classification protocols. Using either symptom survey with either disorder classification protocol provided high sensitivities and specificities (Youden's J >= 0.70). Three of possible six symptom survey/classification protocol pairings provided high sensitivities and specificities across all disorder groups. Conclusion: In this graduate student sample, none of the self-report symptom survey-classification protocol pairings was demonstratively more useful than any other pairing for studies of musculoskeletal disorders among computer users. C1 [Menendez, Cammie Chaumont; Moore, J. Steven] Natl Inst Occupat Safety & Hlth, Ctr Dis Control & Prevent, Div Safety Res, Anal & Field Evaluat Branch, Morgantown, WV 26505 USA. [Amick, Benjamin C., III; Caroom, Cyrus; Harrist, Ronald B.] Univ Texas Houston, Sch Publ Hlth, SW Ctr Occupat & Environm Hlth, Houston, TX USA. [Amick, Benjamin C., III] Inst Work & Hlth, Toronto, ON, Canada. [Jenkins, Mark] Rice Univ, Houston, TX USA. [Caroom, Cyrus] Baylor Coll Med, Houston, TX 77030 USA. [Robertson, Michelle] Liberty Mutual Res Inst Safety, Hopkinton, MA USA. [Gerr, Fred] Univ Iowa, Iowa City, IA USA. [Katz, Jeffrey N.] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. [Katz, Jeffrey N.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Rheumatol Immunol & Allergy, Boston, MA 02115 USA. [Katz, Jeffrey N.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Orthopaed Surg,Orthopaed & Arthrit Ctr Outco, Boston, MA 02115 USA. RP Menendez, CC (reprint author), Natl Inst Occupat Safety & Hlth, Ctr Dis Control & Prevent, Div Safety Res, Anal & Field Evaluat Branch, 1095 Willowdale Rd,MS-1811, Morgantown, WV 26505 USA. EM cmenendez@cdc.gov NR 29 TC 2 Z9 2 U1 0 U2 3 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1051-9815 J9 WORK JI Work PY 2012 VL 43 IS 3 BP 293 EP 302 DI 10.3233/WOR-2012-1401 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 039EB UT WOS:000311225500005 PM 22927597 ER PT B AU McQuiston, JH Paddock, CD AF McQuiston, Jennifer H. Paddock, Christopher D. BE Palmer, GH Azad, AF TI PUBLIC HEALTH: RICKETTSIAL INFECTIONS AND EPIDEMIOLOGY SO INTERCELLULAR PATHOGENS II: RICKETTSIALES LA English DT Article; Book Chapter ID MOUNTAIN-SPOTTED-FEVER; BRILL-ZINSSER-DISEASE; GULF-COAST TICKS; HUMAN GRANULOCYTIC ANAPLASMOSIS; TYPHUS GROUP RICKETTSIOSES; NEWLY RECOGNIZED CAUSE; SUB-SAHARAN AFRICA; NEW-YORK-CITY; UNITED-STATES; MURINE TYPHUS C1 [McQuiston, Jennifer H.] Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Div Vectorborne Dis, Atlanta, GA 30333 USA. [Paddock, Christopher D.] Ctr Dis Control & Prevent, Infect Dis Pathol Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA 30333 USA. RP McQuiston, JH (reprint author), Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Div Vectorborne Dis, Atlanta, GA 30333 USA. NR 194 TC 1 Z9 1 U1 3 U2 8 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA BN 978-1-55581-733-6 PY 2012 BP 40 EP 83 DI 10.1128/9781555817336.ch2 PG 44 WC Biochemistry & Molecular Biology; Infectious Diseases; Microbiology SC Biochemistry & Molecular Biology; Infectious Diseases; Microbiology GA BCI78 UT WOS:000310252800003 ER PT J AU Aharonovich, E Greenstein, E O'Leary, A Johnston, B Seol, SG Hasin, DS AF Aharonovich, Efrat Greenstein, Eliana O'Leary, Ann Johnston, Barbara Seol, Simone G. Hasin, Deborah S. TI HealthCall: Technology-based extension of motivational interviewing to reduce non-injection drug use in HIV primary care patients - a pilot study SO AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV LA English DT Article DE HIV; treatment; drug use; IVR; brief intervention ID INTERACTIVE VOICE RESPONSE; CLINICAL-TRIALS; RISK BEHAVIOR; SELF-REPORTS; INTERVENTION; ALCOHOL; PREVALENCE; SETTINGS; DRINKING; EFFICACY AB To reduce non-injection drug use (NIDU) among HIV primary care patients, more than a single brief intervention may be needed, but clinic resources are often too limited for extended interventions. To extend brief motivational interviewing (MI) to reduce NIDU, we designed and conducted a pilot study of "HealthCall," consisting of brief (1 - 3 minutes) daily patient calls reporting NIDU and health behaviors to a telephone-based interactive voice response (IVR) system, which provided data for subsequent personalized feedback. Urban HIV adult clinic patients reporting] 4 days of NIDU in the previous month were randomized to two groups: MI-only (n = 20) and MI + HealthCall (n = 20). At 30 and 60 days, patients were assessed and briefly discussed their NIDU behaviors with their counselors. The outcome was the number of days patients used their primary drug in the prior 30 days. Medical marijuana issues precluded HealthCall with patients whose primary substance was marijuana (n = 7); excluding these, 33 remained, of whom 28 patients (MI-only n = 17; MI + HealthCall n = 11) provided post-treatment data for analysis. Time significantly predicted reduction in "days used" in both groups (p<0.0001). At 60 days, between-group differences approached trend level, with an effect size of 0.62 favoring the MI + HealthCall arm. This pilot study suggests that HealthCall is feasible and acceptable to patients in resource-limited HIV primary care settings and can extend patient involvement in brief intervention with little additional staff time. A larger efficacy trial of HealthCall for NIDU-reduction in such settings is warranted. C1 [Aharonovich, Efrat; Hasin, Deborah S.] Columbia Univ, Dept Psychiat, New York, NY 10027 USA. [Aharonovich, Efrat; Greenstein, Eliana; Seol, Simone G.; Hasin, Deborah S.] New York State Psychiat Inst & Hosp, New York, NY 10032 USA. [O'Leary, Ann] Ctr Dis Control, Atlanta, GA 30333 USA. [Johnston, Barbara] Mt Sinai Hosp, New York, NY 10029 USA. RP Hasin, DS (reprint author), Columbia Univ, Dept Psychiat, New York, NY 10027 USA. EM dsh2@columbia.edu FU NIAAA NIH HHS [K05 AA014223]; NIDA NIH HHS [K23 DA016743, R01 DA024606] NR 34 TC 11 Z9 11 U1 0 U2 7 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0954-0121 J9 AIDS CARE JI Aids Care-Psychol. Socio-Med. Asp. Aids-Hiv PY 2012 VL 24 IS 12 BP 1461 EP 1469 DI 10.1080/09540121.2012.663882 PG 9 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychology, Multidisciplinary; Respiratory System; Social Sciences, Biomedical SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychology; Respiratory System; Biomedical Social Sciences GA 029HA UT WOS:000310484200001 PM 22428809 ER PT J AU Lindegren, ML Kennedy, CE Bain-Brickley, D Azman, H Creanga, AA Butler, LM Spaulding, AB Horvath, T Kennedy, GE AF Lindegren, Mary Lou Kennedy, Caitlin E. Bain-Brickley, Deborah Azman, Hana Creanga, Andreea A. Butler, Lisa M. Spaulding, Alicen B. Horvath, Tara Kennedy, Gail E. TI Integration of HIV/AIDS services with maternal, neonatal and child health, nutrition, and family planning services SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS LA English DT Review ID INFECTED PREGNANT-WOMEN; HIV-POSITIVE WOMEN; DEVELOPING-COUNTRIES; CONTRACEPTIVE USE; ANTIRETROVIRAL THERAPY; REPRODUCTIVE HEALTH; ANTENATAL CARE; PREVENTION; TRANSMISSION; PROGRAM AB Background The integration of HIV/AIDS and maternal, neonatal, child health and nutrition services (MNCHN), including family planning (FP) is recognized as a key strategy to reduce maternal and child mortality and control the HIV/AIDS epidemic. However, limited evidence exists on the effectiveness of service integration. Objectives To evaluate the impact of integrating MNCHN-FP and HIV/AIDS services on health, behavioral, and economic outcomes and to identify research gaps. Search methods Using the Cochrane Collaboration's validated search strategies for identifying reports of HIV interventions, along with appropriate keywords and MeSH terms, we searched a range of electronic databases, including the Cochrane Central Register of Controlled Trials (CENTRAL), Cumulative Index to Nursing and Allied Health Literature (CINAHL), EMBASE, MEDLINE (via PubMed), and Web of Science / Web of Social Science. The date range was from 01 January 1990 to 15 October 2010. There were no limits to language. Selection criteria Included studies were published in peer-reviewed journals, and provided intervention evaluation data (pre-post or multi-arm study design). The interventions described were organizational strategies or change, process modifications or introductions of technologies aimed at integrating MNCHN-FP and HIV/AIDS service delivery. Data collection and analysis We identified 10,619 citations from the electronic database searches and 101 citations from hand searching, cross-reference searching and interpersonal communication. After initial screenings for relevance by pairs of authors working independently, a total of 121 full-text articles were obtained for closer examination. Main results Twenty peer-reviewed articles representing 19 interventions met inclusion criteria. There were no randomized controlled trials. One study utilized a stepped wedge design, while the rest were non-randomized trials, cohort studies, time series studies, cross-sectional studies, serial cross-sectional studies, and before-after studies. It was not possible to perform meta-analysis. Risk of bias was generally high. We found high between-study heterogeneity in terms of intervention types, study objectives, settings and designs, and reported outcomes. Most studies integrated FP with HIV testing (n=7) or HIV care and treatment (n=4). Overall, HIV and MNCHN-FP service integration was found to be feasible across a variety of integration models, settings and target populations. Nearly all studies reported positive post-integration effects on key outcomes including contraceptive use, antiretroviral therapy initiation in pregnancy, HIV testing, and quality of services. Authors' conclusions This systematic review's findings show that integrated HIV/AIDS and MNCHN-FP services are feasible to implement and show promise towards improving a variety of health and behavioral outcomes. However, significant evidence gaps remain. Rigorous research comparing outcomes of integrated with non-integrated services, including cost, cost-effectiveness, and health outcomes such as HIV and STI incidence, morbidity and mortality are greatly needed to inform programs and policy. C1 [Lindegren, Mary Lou] Vanderbilt Univ, Vanderbilt Inst Global Hlth, Nashville, TN 37203 USA. [Kennedy, Caitlin E.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Social & Behav Intervent Program, Baltimore, MD USA. [Bain-Brickley, Deborah; Azman, Hana; Butler, Lisa M.; Horvath, Tara; Kennedy, Gail E.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Creanga, Andreea A.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA. [Spaulding, Alicen B.] Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN USA. RP Lindegren, ML (reprint author), Vanderbilt Univ, Vanderbilt Inst Global Hlth, Nashville, TN 37203 USA. EM mllindegren@gmail.com FU USAID Bureau for Global Health in Washington D.C. FX We thank Mary Ann Abeyta-Behneke and Milly Kayongo and their colleagues at USAID Bureau for Global Health in Washington D.C. for funding for this projects and ongoing guidance on the development of the protocol, analysis, and interpretation. We also thank Maggie Rajala of GH tech who provided administrative support. NR 58 TC 11 Z9 11 U1 2 U2 25 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1469-493X J9 COCHRANE DB SYST REV JI Cochrane Database Syst Rev. PY 2012 IS 9 AR CD010119 DI 10.1002/14651858.CD010119 PG 125 WC Medicine, General & Internal SC General & Internal Medicine GA 006ON UT WOS:000308828600015 PM 22972150 ER PT J AU Kraft, JM Hill, Z Membe, I Zhang, YJ Meassick, EO Monsour, M Maumbi, M Ndubani, P Manengu, JM Mwinga, A AF Kraft, Joan Marie Hill, Zelee Membe, Ian Zhang, Yujia Meassick, Elizabeth Onjoro Monsour, Michael Maumbi, Mwendalubi Ndubani, Phillimon Manengu, Joy Masheke Mwinga, Alwyn TI Effects of the Gama Cuulu Radio Serial Drama on HIV-Related Behavior Change in Zambia SO JOURNAL OF HEALTH COMMUNICATION LA English DT Article ID HIV/AIDS; PREVENTION; CAMPAIGNS; CHILDREN; VIOLENCE; WOMEN AB The Gama Cuulu radio serial drama is written and produced in Zambia's Southern Province. It promotes behavior change and service use to prevent HIV transmission. The authors evaluated the effects of Gama Cuulu on intermediate outcomes (e.g., perceived norms), as well as number of sexual partners, condom use, and HIV testing in the past year among adults between 18 and 49 years of age. The authors used a pretest/posttest assessment with a comparison group design, with Southern Province as the intervention area and Western Province as the comparison area. Approximately 1,500 in-person interviews were conducted in both provinces in 2006 (pretest), 2007, and 2008. Regression models included terms for province, time, and the interaction of the two. Outcomes improved in both provinces (e. g., by 2008, 37.6% of participants in Southern Province and 28.3% participants in Western Province tested for HIV in the past year). Pretest-to-posttest changes in condom use (from 20.2% to 29.4% in Southern Province) and 5 intermediate outcomes were significantly different in the 2 provinces. However, changes in condom use were not associated with listening to Gama Cuulu and changes in other outcomes were similar in both provinces. Weak intervention effects might be attributable to implementation challenges or the saturation of HIV programs in Zambia. C1 [Kraft, Joan Marie] US Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA. [Hill, Zelee] UCL, Inst Child Hlth, London, England. [Membe, Ian; Ndubani, Phillimon; Mwinga, Alwyn] US Ctr Dis Control & Prevent, Lusaka, Zambia. [Meassick, Elizabeth Onjoro] World Vis Int, Nairobi, Kenya. [Maumbi, Mwendalubi] MARCH Zambia, Livingstone, Zambia. [Manengu, Joy Masheke] USAID, Lusaka, Zambia. RP Kraft, JM (reprint author), US Ctr Dis Control & Prevent, Div Reprod Hlth, 4770 Buford Highway NE,MS K34, Atlanta, GA 30341 USA. EM jik4@cdc.gov FU PEPFAR NR 24 TC 3 Z9 3 U1 0 U2 9 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1081-0730 J9 J HEALTH COMMUN JI J. Health Commun. PY 2012 VL 17 IS 8 BP 929 EP 945 DI 10.1080/10810730.2011.650834 PG 17 WC Communication; Information Science & Library Science SC Communication; Information Science & Library Science GA 019ON UT WOS:000309749300006 PM 22568558 ER PT J AU Raut, CG Yadav, PD Towner, JS Amman, BR Erickson, BR Cannon, DL Sivaram, A Basu, A Nichol, ST Mishra, AC Mourya, DT AF Raut, C. G. Yadav, P. D. Towner, J. S. Amman, B. R. Erickson, B. R. Cannon, D. L. Sivaram, A. Basu, A. Nichol, S. T. Mishra, A. C. Mourya, D. T. TI Isolation of a Novel Adenovirus from Rousettus leschenaultii Bats from India SO INTERVIROLOGY LA English DT Article DE Adenovirus; Rousettus; PCR; Pteropus bat ID NIPAH VIRUS; HOST AB Surveillance work was initiated to study the presence of highly infectious diseases like Ebola-Reston, Marburg, Nipah and other possible viruses that are known to be found in the bat species and responsible for causing diseases in humans. A novel adenovirus was isolated from a common species of fruit bat (Rousettus leschenaultii) captured in Maharashtra State, India. Partial sequence analysis of the DNA polymerase gene shows this isolate to be a newly recognized member of the genus Mastadenovirus (family Adenoviridae), approximately 20% divergent at the nucleotide level from Japanese BatAdV, its closest known relative. Copyright (C) 2012 S. Karger AG, Basel C1 [Raut, C. G.; Yadav, P. D.; Sivaram, A.; Basu, A.; Mishra, A. C.; Mourya, D. T.] Natl Inst Virol, Pune 40, Maharashtra, India. [Towner, J. S.; Amman, B. R.; Erickson, B. R.; Cannon, D. L.; Nichol, S. T.] Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA USA. RP Mourya, DT (reprint author), Natl Inst Virol, Microbial Containment Complex,Sus Rd, Pune 40, Maharashtra, India. EM mourya.dt@niv.co.in NR 14 TC 9 Z9 9 U1 0 U2 3 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0300-5526 J9 INTERVIROLOGY JI Intervirology PY 2012 VL 55 IS 6 BP 488 EP 490 DI 10.1159/000337026 PG 3 WC Virology SC Virology GA 016LF UT WOS:000309519100011 PM 22572722 ER PT J AU Lopez, LM Chen, M Mullins, S Curtis, KM Helmerhorst, FM AF Lopez, Laureen M. Chen, Mario Mullins, Sarah Curtis, Kathryn M. Helmerhorst, Frans M. TI Steroidal contraceptives and bone fractures in women: evidence from observational studies SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS LA English DT Review ID DEPOT MEDROXYPROGESTERONE ACETATE; RANDOMIZED CONTROLLED-TRIAL; MINERAL DENSITY; RISK-FACTORS; ORAL-CONTRACEPTION; HORMONAL CONTRACEPTION; PERIMENOPAUSAL WOMEN; DISTAL FOREARM; HIP FRACTURE; VITAMIN-D AB Background Age-related decline in bone mass increases the risk of skeletal fractures, especially those of the hip, spine, and wrist. Steroidal contraceptives have been associated with changes in bone mineral density in women. Whether such changes affect the risk of fractures later in life is unclear. Hormonal contraceptives are among the most effective and most widely-used contraceptives. Concern about fractures may limit the use of these effective contraceptives. Observational studies can collect data on premenopausal contraceptive use as well as fracture incidence later in life. Objectives We systematically reviewed the evidence from observational studies of hormonal contraceptive use for contraception and the risk of fracture in women. Search methods In May 2012, we searched for observational studies. The databases included MEDLINE, POPLINE, Cochrane Central Register of Controlled Trials (CENTRAL), LILACS, EMBASE, CINAHL, and Web of Science. We also searched for recent clinical trials through ClinicalTrials.gov and the ICTRP. For other studies, we examined reference lists of relevant articles and wrote to investigators for additional reports. Selection criteria We included cohort and case-control studies of hormonal contraceptive use. Interventions included comparisons of a hormonal contraceptive with a nonhormonal contraceptive, no contraceptive, or another hormonal contraceptive. The primary outcome was the risk of fracture. Data collection and analysis Two authors independently extracted the data. One author entered the data into RevMan, and a second author verified accuracy. We examined the quality of evidence using the Newcastle-Ottawa Quality Assessment Scale (NOS), developed for case-control and cohort studies. Sensitivity analysis included studies of moderate or high quality based on our assessment with the NOS. Given the need to control for confounding factors in observational studies, we used adjusted estimates from the models as reported by the authors. Where we did not have adjusted analyses, we calculated the odds ratio (OR) with 95% confidence interval (CI). Due to varied study designs, we did not conduct meta-analysis. Main results We included 14 studies (7 case-control and 7 cohort studies). These examined oral contraceptives (OCs) (N=12), depot medroxyprogesterone acetate (DMPA) (N=4), and the hormonal intrauterine device (IUD) (N=1). This section focuses on evidence from the six studies with moderate or high quality evidence that we included in the sensitivity analysis. All six studies examined oral contraceptive use. We noted few associations with fracture risk. One cohort study found OC ever-users had increased risk for all fractures (reported RR 1.20; 95% CI 1.08 to 1.34). However, a case-control study with later data from a subset reported no association except for those with 10 years or more since use (reported OR 1.55; 95% CI 1.03 to 2.33). Another case-control study reported increased risk only for those who had 10 or more prescriptions (reported OR 1.09; 95% CI 1.03 to 1.16). A cohort study of postmenopausal women found no increased fracture risk for OC use after excluding women with prior fracture. Two other studies found little evidence of association between OC use and fracture risk. A cohort study noted increased risk for subgroups, such as those with longer use or specific intervals since use. A case-control study reported increased risk for any fracture only among young women with less than average use. Two case-control studies in the sensitivity analysis also examined progestin-only contraceptives. One reported increased fracture risk for DMPA ever-use (reported OR 1.44 (95% CI 1.01 to 2.06), more than four years of use (reported OR 2.16; 95% CI 1.32 to 3.53), and women over 50 years old. The other noted increased risk for any past use, including one or two prescriptions (reported OR 1.17; 95% CI 1.07 to 1.29), and for current use of 3 to 9 or 10 or more prescriptions. In addition, one study reported reduced fracture risk for ever-use of the hormonal IUD (reported OR 0.75; 95% CI 0.64 to 0.87) and longer use of that IUD. Authors' conclusions Observational studies do not indicate an overall association between OC use and fracture risk. Some reported increased risk for specific user subgroups. DMPA users may have an increased fracture risk. One study indicated hormonal IUD use may be associated with decreased risk. Observational studies need adjusted analysis because the comparison groups usually differ. Researchers should be clear about the variables examined in multivariate analysis. C1 [Lopez, Laureen M.; Mullins, Sarah] FHI 360, Clin Sci, Res Triangle Pk, NC 27709 USA. [Chen, Mario] FHI 360, Div Biostat, Res Triangle Pk, NC 27709 USA. [Curtis, Kathryn M.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA. [Helmerhorst, Frans M.] Leiden Univ, Med Ctr, Dept Gynaecol, Div Reprod Med, Leiden, Netherlands. [Helmerhorst, Frans M.] Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands. RP Lopez, LM (reprint author), FHI 360, Clin Sci, POB 13950, Res Triangle Pk, NC 27709 USA. EM llopez@fhi360.org FU National Institute of Child Health and Human Development, USA; United States Agency for International Development, USA FX External sources; National Institute of Child Health and Human Development, USA. Funding to FHI 360 for conducting the review (LML, SM, MC); United States Agency for International Development, USA. Funding to FHI 360 for conducting the review (LML, SM, MC) NR 61 TC 5 Z9 5 U1 1 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1469-493X J9 COCHRANE DB SYST REV JI Cochrane Database Syst Rev. PY 2012 IS 8 AR CD009849 DI 10.1002/14651858.CD009849.pub2 PG 65 WC Medicine, General & Internal SC General & Internal Medicine GA 993BK UT WOS:000307828900039 PM 22895991 ER PT J AU Bergdall, AR Kraft, JM Andes, K Carter, M Hatfield-Timajchy, K Hock-Long, L AF Bergdall, Anna R. Kraft, Joan Marie Andes, Karen Carter, Marion Hatfield-Timajchy, Kendra Hock-Long, Linda TI Love and Hooking Up in the New Millennium: Communication Technology and Relationships among Urban African American and Puerto Rican Young Adults SO JOURNAL OF SEX RESEARCH LA English DT Article ID SEXUALLY-TRANSMITTED INFECTIONS; RISK; INTERNET; SEX; ADOLESCENTS; PARTNERS; DISEASES; COUPLES; ONLINE; HIV AB Communication technology is a central feature of young people's lives, but its role in romantic and sexual relationships has not been thoroughly examined. This article describes how young adults use communication technology for partnering across relationship stages (formation, maintenance, and dissolution) and types (serious/casual), and proposes implications of usage in relationships. This study analyzed qualitative data from a five-week, prospective, coital diary method with related debriefing interviews (N = 70) of African American and Puerto Rican men and women aged 18 to 25 years in Hartford and Philadelphia. Cell phones, including calls, text messaging, and mobile Internet, were the most common forms of communication technology used for partnering goals. Participants reported using cell phones to pursue partnering goals across all relationship stages, including formation (meeting, screening, and getting to know new partners), maintaining existing relationships, and breaking up. Cell phone uses depended on the type of relationship (serious/casual) and the participants' intentions and desires. Results indicated that cell phones are an important element of communication among young adults in romantic and sexual relationships. Specific features of cell phone communication shape the process and context of partnering. Future research should explore emerging communication technologies and implications for psychosocial development, dating violence, and sexual behavior. C1 [Bergdall, Anna R.] US Ctr Dis Control & Prevent, Oak Ridge Inst Sci & Educ, Div Reprod Hlth, Atlanta, GA 30341 USA. [Andes, Karen] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. RP Bergdall, AR (reprint author), US Ctr Dis Control & Prevent, Oak Ridge Inst Sci & Educ, Div Reprod Hlth, 4770 Buford Hwy,MS K-34, Atlanta, GA 30341 USA. EM abergdall@cdc.gov FU PHS HHS [U58/CCU123064, U58/CCU323065] NR 29 TC 6 Z9 7 U1 2 U2 31 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0022-4499 J9 J SEX RES JI J. Sex Res. PY 2012 VL 49 IS 6 BP 570 EP 582 DI 10.1080/00224499.2011.604748 PG 13 WC Psychology, Clinical; Social Sciences, Interdisciplinary SC Psychology; Social Sciences - Other Topics GA 008WA UT WOS:000308986100005 PM 21854226 ER PT J AU Horvath, KJ Wilkerson, JM McFarlane, M Courtenay-Quirk, C AF Horvath, Keith J. Wilkerson, J. Michael McFarlane, Mary Courtenay-Quirk, Cari TI Developing and maintaining HIV-related websites: a view from the other side SO SEXUAL AND RELATIONSHIP THERAPY LA English DT Article DE website development; content decisions; format decisions; Internet ID HEALTH INFORMATION; WEB SITES; INTERNET; HIV/AIDS; SEX AB Technology is an increasingly necessary tool for therapists to maintain a successful practice. Studies have not examined how decisions about the content and format of health-related websites are made, which may help providers direct clients to more credible online resources and provide suggestions of how to most efficiently develop a professional website. As an example, the overall aim of this study was to examine the decision-making processes of persons who manage HIV-related websites. A total of 21 managers representing 19 HIV-related websites completed a semi-structured, telephone interview to understand how decisions are made about the content and design of their websites, the purpose of their website and their educational background. Interviews were digitally recorded, transcribed and imported into N-Vivo for analysis. Results showed that informational clearinghouse websites played a central role in developing content to place on their websites, while research and medical facilities tended to rely on experts in their organizations to develop content. Format decisions were primarily affected by user bandwidth and resource requirements of different formats. Few managers reported receiving feedback from users about their website. Managers described the need for ongoing training of the latest technology developments in their field. Implications for sexual and relationship therapists are discussed. C1 [Horvath, Keith J.; Wilkerson, J. Michael] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN 55455 USA. [McFarlane, Mary] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA USA. [Courtenay-Quirk, Cari] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. RP Horvath, KJ (reprint author), Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN 55455 USA. EM horva018@umn.edu NR 19 TC 1 Z9 1 U1 0 U2 4 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1468-1994 J9 SEX RELATSH THER JI Sex. Relatsh. Ther. PY 2012 VL 27 IS 2 BP 162 EP 175 DI 10.1080/14681994.2012.686662 PG 14 WC Psychology, Clinical SC Psychology GA 978MJ UT WOS:000306745500007 ER PT J AU McCanlies, EC Slaven, JE Smith, LM Andrew, ME Charles, LE Burchfiel, CM Violanti, JM AF McCanlies, Erin C. Slaven, James E. Smith, Lindsay M. Andrew, Michael E. Charles, Luenda E. Burchfiel, Cecil M. Violanti, John M. TI Metabolic syndrome and sleep duration in police officers SO WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION LA English DT Article DE Short sleep; occupation; sleep quality ID NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; LONG WORK HOURS; APNEA; PREVALENCE; ASSOCIATION; QUALITY; IMPACT; MEN; MORTALITY AB Objectives: To examine associations for sleep quality and quantity with metabolic syndrome (MS) and its five components in police officers. Patients or Participants: The study population consisted of 98 randomly selected officers (39 women and 59 men) for whom MS and sleep data were available. Methods: Sleep duration (categorized as short < 6 hours, long >= 6 hours) for the past week and quality of sleep were collected by interviewer-administered questionnaires. MS was assessed using standard criteria. Generalized linear models were used to assess associations between sleep duration or sleep quality and MS, and the mean number of MS components. Results: Metabolic syndrome was present in 22.0% and 2.6% of the male and female officers, respectively. Women with short sleep had a significantly higher mean number of MS components (mean = 1.43) than those with longer sleep (mean = 0.81, p = 0.0316). Officers who stopped breathing during the night had more MS components (mean = 2.43) compared to those who did not (mean = 1.13, p = 0.0206). Conclusions: Sleep duration and quality were associated with the mean number of MS components, particularly in women. Future research should examine these associations prospectively, in a larger cohort, exploring possible gender differences. C1 [McCanlies, Erin C.; Slaven, James E.; Andrew, Michael E.; Charles, Luenda E.; Burchfiel, Cecil M.] NIOSH, Biostat & Epidemiol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. [Smith, Lindsay M.] W Virginia Univ, Dept Psychol, Morgantown, WV 26506 USA. [Violanti, John M.] SUNY Buffalo, Dept Social & Prevent Med, Sch Publ Hlth & Hlth Profess, Buffalo, NY 14260 USA. RP McCanlies, EC (reprint author), NIOSH, Biostat & Epidemiol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, MS 4050,1095 Willowdale Rd, Morgantown, WV 26505 USA. EM EIM4@CDC.GOV FU NIOSH CDC HHS [1R03OH003772-01] NR 35 TC 12 Z9 12 U1 0 U2 8 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1051-9815 J9 WORK JI Work PY 2012 VL 43 IS 2 BP 133 EP 139 DI 10.3233/WOR-2012-1399 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 012CX UT WOS:000309214100004 PM 22927620 ER PT J AU Cauda, EG Ku, BK Miller, AL Barone, TL AF Cauda, Emanuele G. Ku, Bon Ki Miller, Arthur L. Barone, Teresa L. TI Toward Developing a New Occupational Exposure Metric Approach for Characterization of Diesel Aerosols SO AEROSOL SCIENCE AND TECHNOLOGY LA English DT Article ID PARTICLE SURFACE-AREA; TRANSMISSION ELECTRON-MICROSCOPY; PARTICULATE MATTER; EXHAUST PARTICLES; MOBILITY ANALYSIS; SIZE-DISTRIBUTION; FINE PARTICLES; NANOPARTICLES; ENGINE; MASS AB The extensive use of diesel-powered equipment in mines makes the exposure to diesel aerosols a serious occupational issue. The exposure metric currently used in U. S. underground noncoal mines is based on the measurement of total carbon (TC) and elemental carbon (EC) mass concentration in the air. Recent toxicological evidence suggests that the measurement of mass concentration is not sufficient to correlate ultrafine aerosol exposure with health effects. This urges the evaluation of alternative measurements. In this study, the current exposure metric and two additional metrics, the surface area and the total number concentration, were evaluated by conducting simultaneous measurements of diesel ultrafine aerosols in a laboratory setting. The results showed that the surface area and total number concentration of the particles per unit of mass varied substantially with the engine operating condition. The specific surface area (SSA) and specific number concentration (SNC) normalized with TC varied two and five times, respectively. This implies that miners, whose exposure is measured only as TC, might be exposed to an unknown variable number concentration of diesel particles and commensurate particle surface area. Taken separately, mass, surface area, and number concentration did not completely characterize the aerosols. A comprehensive assessment of diesel aerosol exposure should include all of these elements, but the use of laboratory instruments in underground mines is generally impracticable. The article proposes a new approach to solve this problem. Using SSA and SNC calculated from field-type measurements, the evaluation of additional physical properties can be obtained by using the proposed approach. C1 [Cauda, Emanuele G.; Miller, Arthur L.] NIOSH, US Dept Hlth & Human Serv, Publ Hlth Serv, Ctr Dis Control & Prevent,Off Min Safety & Hlth R, Pittsburgh, PA 15236 USA. [Ku, Bon Ki] NIOSH, US Dept Hlth & Human Serv, Publ Hlth Serv, Ctr Dis Control & Prevent,Div Appl Res & Technol, Cincinnati, OH 45226 USA. [Barone, Teresa L.] Oak Ridge Natl Lab, Emiss & Catalysts Res Ctr, Knoxville, TN USA. RP Cauda, EG (reprint author), NIOSH, US Dept Hlth & Human Serv, Publ Hlth Serv, Ctr Dis Control & Prevent,Off Min Safety & Hlth R, 626 Cochrans Mill Rd, Pittsburgh, PA 15236 USA. EM ecauda@cdc.gov RI Cauda, Emanuele/A-7168-2011 FU Intramural CDC HHS [CC999999] NR 52 TC 16 Z9 16 U1 2 U2 10 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0278-6826 J9 AEROSOL SCI TECH JI Aerosol Sci. Technol. PY 2012 VL 46 IS 12 BP 1370 EP 1381 DI 10.1080/02786826.2012.715781 PG 12 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 001FG UT WOS:000308445200010 PM 26361400 ER PT S AU Foltz, JL May, AL Belay, B Nihiser, AJ Dooyema, CA Blanck, HM AF Foltz, Jennifer L. May, Ashleigh L. Belay, Brook Nihiser, Allison J. Dooyema, Carrie A. Blanck, Heidi M. BE Cousins, RJ TI Population-Level Intervention Strategies and Examples for Obesity Prevention in Children SO ANNUAL REVIEW OF NUTRITION, VOL 32 SE Annual Review of Nutrition LA English DT Review; Book Chapter DE obesity prevention; children; nutrition; physical activity; interventions ID RANDOMIZED CONTROLLED-TRIAL; COMMUNITY-HEALTH WORKERS; PHYSICAL-ACTIVITY; CHILDHOOD OBESITY; ADOLESCENT OVERWEIGHT; PRESCHOOL-CHILDREN; NUTRIENT INTAKE; FAMILY DINNER; UNITED-STATES; PRIMARY-CARE AB With obesity affecting approximately 12.5 million American youth, population-level interventions are indicated to help support healthy behaviors. The purpose of this review is to provide a summary of population-level intervention strategies and specific intervention examples that illustrate ways to help prevent and control obesity in children through improving nutrition and physical activity behaviors. Information is summarized within the settings where children live, learn, and play (early care and education, school, community, health care, home). Intervention strategies are activities or changes intended to promote healthful behaviors in children. They were identified from (a) systematic reviews; (b) evidence- and expert consensus-based recommendations, guidelines, or standards from nongovernmental or federal agencies; and finally (c) peer-reviewed synthesis reviews. Intervention examples illustrate how at least one of the strategies was used in a particular setting. To identify interventions examples, we considered (a) peer-reviewed literature as well as (b) additional sources with research-tested and practice-based initiatives. Researchers and practitioners may use this review as they set priorities and promote integration across settings and to find research- and practice-tested intervention examples that can be replicated in their communities for childhood obesity prevention. C1 [Foltz, Jennifer L.; May, Ashleigh L.; Belay, Brook; Dooyema, Carrie A.; Blanck, Heidi M.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Nihiser, Allison J.] Ctr Dis Control & Prevent, Div Populat Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Foltz, JL (reprint author), Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. EM JFoltz@cdc.gov RI Nihiser, Allison/B-8662-2014 NR 125 TC 39 Z9 40 U1 5 U2 58 PU ANNUAL REVIEWS PI PALO ALTO PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA SN 0199-9885 BN 978-0-8243-2832-0 J9 ANNU REV NUTR JI Annu. Rev. Nutr. PY 2012 VL 32 BP 391 EP + DI 10.1146/annurev-nutr-071811-150646 PG 27 WC Nutrition & Dietetics SC Nutrition & Dietetics GA BBR29 UT WOS:000307963100019 PM 22540254 ER PT J AU Varma, JK Wu, SY Feng, ZJ AF Varma, Jay K. Wu, Shuyu Feng, Zijian TI Detecting and controlling foodborne infections in humans: Lessons for China from the United States experience SO GLOBAL PUBLIC HEALTH LA English DT Article DE China; United States; foodborne infections; Salmonella; surveillance; food safety ID NONTYPHOIDAL SALMONELLA INFECTIONS; ESCHERICHIA-COLI; HEALTH SYSTEM; SURVEILLANCE; OUTBREAK; DISEASE; ILLNESS; BURDEN AB In the past 50 years, the United States has made major advances in human health surveillance, research and outbreak investigation that have helped reduce microbial contamination of food. In China, food safety has emerged as one of the country's most prominent domestic concerns, but there has been limited investment in surveillance, inter-agency coordination, outbreak investigation and data synthesis. After large outbreaks of Salmonella in the 1960s and E. coli O157:H7 in the 1990s, the United States transformed its approach to detecting and investigating foodborne infections, including deployment of a national, laboratory-based surveillance system that uses molecular subtyping. In China, the absence of a national, laboratory-based surveillance system means that it is difficult to rapidly detect a widely dispersed foodborne infection outbreak or the emergence of new foodborne infections. Based on lessons learned in the United States, we propose policy and administrative changes that China can adopt to strengthen detection and control of foodborne infections. C1 [Varma, Jay K.; Wu, Shuyu; Feng, Zijian] US Ctr Dis Control & Prevent, China US Collaborat Program Emerging & Reemerging, Beijing, Peoples R China. [Varma, Jay K.] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Feng, Zijian] Chinese Ctr Dis Control & Prevent, Off Dis Control & Emergency Response, Beijing, Peoples R China. RP Varma, JK (reprint author), US Ctr Dis Control & Prevent, China US Collaborat Program Emerging & Reemerging, Beijing, Peoples R China. EM jvarma@cdc.gov NR 51 TC 1 Z9 1 U1 1 U2 6 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1744-1692 J9 GLOB PUBLIC HEALTH JI Glob. Public Health PY 2012 VL 7 IS 7 SI SI BP 766 EP 778 DI 10.1080/17441692.2011.641988 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 995RU UT WOS:000308030800008 PM 22175805 ER PT J AU Shui, IM Rett, MD Weintraub, E Marcy, M Amato, AA Sheikh, SI Ho, D Lee, GM Yih, WK AF Shui, Irene M. Rett, Melisa D. Weintraub, Eric Marcy, Michael Amato, Anthony A. Sheikh, Sarah I. Ho, Doreen Lee, Grace M. Yih, W. Katherine CA Vaccine Safety Datalink Res Team TI Guillain-Barre Syndrome Incidence in a Large United States Cohort (2000-2009) SO NEUROEPIDEMIOLOGY LA English DT Article DE Guillain-Barre syndrome; Epidemiology; Incidence rates; Infection ID VACCINE SAFETY DATALINK; PUBLIC-HEALTH SURVEILLANCE; PRACTICE RESEARCH DATABASE; INFLUENZA VACCINATION; ADVERSE EVENTS; IMMUNIZATION; ASSOCIATION; RATES; INFECTION; PROJECT AB Background/Aim: We describe the incidence of Guillain-Barre syndrome (GBS) in a large United States cohort. Methods: Between 2000 and 2009, we identified visits with an ICD-9 code for GBS (357.0) from all persons with continuous enrollment for at least 1 year. The primary case definition was restricted to emergency department and inpatient visits. We calculated age-standardized rates and used multivariate Poisson regression to assess variation in rates by sex, age, season and year of diagnosis. We tabulated descriptive characteristics and the positive predictive value (PPV) for a subset of the visits with available medical record review. Results: 1,619 visits with the GBS ICD-9 code were identified from 50,290,898 person-years of observation. After considering the PPV (55%) for record-reviewed visits, the age-standardized incidence rate was approximately 1.72/100,000 person-years. The rate was 40% higher for males and increased by 50% for every 10-year increase in age. The rate was 15% higher in winter and spring compared with summer. Rates were higher in more recent years. Conclusions: GBS rates are higher in males and increase considerably with age. The potential reasons for differences in rates by season and the increased rates in more recent years should be further investigated. Copyright (C) 2012 S. Karger AG, Basel C1 [Shui, Irene M.; Rett, Melisa D.; Lee, Grace M.; Yih, W. Katherine] Harvard Univ, Sch Med, Dept Populat Med, Boston, MA USA. [Shui, Irene M.; Rett, Melisa D.; Lee, Grace M.; Yih, W. Katherine] Harvard Pilgrim Hlth Care Inst, Boston, MA USA. [Shui, Irene M.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Amato, Anthony A.; Sheikh, Sarah I.; Ho, Doreen] Brigham & Womens Hosp, Dept Neurol, Boston, MA 02115 USA. [Lee, Grace M.] Childrens Hosp, Dept Lab Med, Boston, MA 02115 USA. [Lee, Grace M.] Childrens Hosp, Div Infect Dis, Boston, MA 02115 USA. [Weintraub, Eric] Ctr Dis Control & Prevent, Immunizat Safety Off, Div Healthcare Qual & Promot, Atlanta, GA USA. [Marcy, Michael] Kaiser Permanente So Calif, Pasadena, CA USA. RP Shui, IM (reprint author), 677 Huntington Ave, Boston, MA 02115 USA. EM ishui@hsph.harvard.edu OI Irving, Stephanie/0000-0001-7437-6797 FU America's Health Insurance Plans (AHIP) [200-2002-00732]; Centers for Disease Control and Prevention (CDC) FX This study was funded through a subcontract with America's Health Insurance Plans (AHIP) under contract 200-2002-00732 from the Centers for Disease Control and Prevention (CDC). NR 30 TC 20 Z9 21 U1 0 U2 2 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0251-5350 EI 1423-0208 J9 NEUROEPIDEMIOLOGY JI Neuroepidemiology PY 2012 VL 39 IS 2 BP 109 EP 115 DI 10.1159/000339248 PG 7 WC Public, Environmental & Occupational Health; Clinical Neurology SC Public, Environmental & Occupational Health; Neurosciences & Neurology GA 005DP UT WOS:000308731000006 PM 22846726 ER PT J AU Thompson, KM Wallace, GS Tebbens, RJD Smith, PJ Barskey, AE Pallansch, MA Gallagher, KM Alexander, JP Armstrong, GL Cochi, SL Wassilak, SGF AF Thompson, Kimberly M. Wallace, Gregory S. Tebbens, Radboud J. Duintjer Smith, Philip J. Barskey, Albert E. Pallansch, Mark A. Gallagher, Kathleen M. Alexander, James P. Armstrong, Gregory L. Cochi, Stephen L. Wassilak, Steven G. F. TI Trends in the Risk of U.S. Polio Outbreaks and Poliovirus Vaccine Availability for Response SO PUBLIC HEALTH REPORTS LA English DT Article ID UNITED-STATES; MEASLES OUTBREAK; POLIOMYELITIS OUTBREAKS; PRESCHOOL-CHILDREN; MUCOSAL IMMUNITY; ECONOMIC-IMPACT; SAN-DIEGO; IMMUNIZATION; POPULATION; EXCRETION AB Objectives. The United States eliminated indigenous wild polioviruses (WPVs) in 1979 and switched to inactivated poliovirus vaccine in 2000, which quickly ended all indigenous live poliovirus transmission. Continued WPV circulation and use of oral poliovirus vaccine globally allow for the possibility of reintroduction of these viruses. We evaluated the risk of a U.S. polio outbreak and explored potential vaccine needs for outbreak response. Methods. We synthesized information available on vaccine coverage, exemptor populations, and population immunity. We used an infection transmission model to explore the potential dynamics of a U.S. polio outbreak and potential vaccine needs for outbreak response, and assessed the impacts of heterogeneity in population immunity for two different subpopulations with potentially low coverage. Results. Although the risk of poliovirus introduction remains real, widespread transmission of polioviruses appears unlikely in the U.S., given high routine coverage. However, clusters of un- or underimmunized children might create pockets of susceptibility that could potentially lead to one or more paralytic polio cases. We found that the shift toward combination vaccine utilization, with limited age indications for use, and other current trends (e.g., decreasing proportion of the population with immunity induced by live polioviruses and aging of vaccine exemptor populations) might increase the vulnerability to poliovirus reintroduction at the same time that the ability to respond may decrease. Conclusions. The U.S. poliovirus vaccine stockpile remains an important resource that may potentially be needed in the future to respond to an outbreak if a live poliovirus gets imported into a subpopulation with low vaccination coverage. C1 [Thompson, Kimberly M.; Tebbens, Radboud J. Duintjer] Kid Risk Inc, Newton, MA 02459 USA. [Wallace, Gregory S.; Smith, Philip J.; Barskey, Albert E.; Pallansch, Mark A.; Gallagher, Kathleen M.; Alexander, James P.; Armstrong, Gregory L.; Cochi, Stephen L.; Wassilak, Steven G. F.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Thompson, KM (reprint author), Kid Risk Inc, POB 590129, Newton, MA 02459 USA. EM kimt@kidrisk.org FU CDC [200-2010-M-33679] FX Drs. Thompson and Duintjer Tebbens were supported by CDC contract #200-2010-M-33679. The findings and conclusions in this article are those of the authors and do not necessarily represent the views of CDC. This work did not require Institutional Review Board determination. NR 63 TC 18 Z9 18 U1 1 U2 4 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD JAN-FEB PY 2012 VL 127 IS 1 BP 23 EP 37 PG 15 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 002DF UT WOS:000308510500004 PM 22298920 ER PT J AU Kucik, JE Alverson, CJ Gilboa, SM Correa, A AF Kucik, James E. Alverson, Clinton J. Gilboa, Suzanne M. Correa, Adolfo TI Racial/Ethnic Variations in the Prevalence of Selected Major Birth Defects, Metropolitan Atlanta, 1994-2005 SO PUBLIC HEALTH REPORTS LA English DT Article ID CONGENITAL HEART-DEFECTS; NEURAL-TUBE DEFECTS; UNITED-STATES; DOWN-SYNDROME; SOCIOECONOMIC MEASURES; SOCIAL INEQUALITIES; MATERNAL NATIVITY; OROFACIAL CLEFTS; CLUB FOOT; MALFORMATIONS AB Objectives. Birth defects are the leading cause of infant mortality and are responsible for substantial child and adult morbidity. Documenting the variation in prevalence of birth defects among racial/ethnic subpopulations is critical for assessing possible variations in diagnosis, case ascertainment, or risk factors among such groups. Methods. We used data from the Metropolitan Atlanta Congenital Defects Program, a population-based birth defects registry with active case ascertainment. We estimated the racial/ethnic variation in prevalence of 46 selected major birth defects among live births, stillbirths, and pregnancy terminations at >20 weeks gestation among mothers residing in the five central counties of metropolitan Atlanta between 1994 and 2005, adjusting for infant sex, maternal age, gravidity, and socioeconomic status (SES). We also explored SES as a potential effect measure modifier. Results. Compared with births to non-Hispanic white women, births to non-Hispanic black women had a significantly higher prevalence of five birth defects and a significantly lower prevalence of 10 birth defects, while births to Hispanic women had a significantly higher prevalence of four birth defects and a significantly lower prevalence of six birth defects. The racial/ethnic disparities in the prevalence of some defects varied by SES, but no clear pattern emerged. Conclusions. Racial/ethnic disparities were suggested in 57% of included birth defects. Disparities in the prevalence of birth defects may result from different underlying genetic susceptibilities; exposure to risk factors; or variability in case diagnosis, ascertainment, or reporting among the subpopulations examined. Policies that improve early diagnosis of birth defects could reduce associated morbidity and mortality. C1 [Kucik, James E.; Alverson, Clinton J.; Gilboa, Suzanne M.; Correa, Adolfo] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Kucik, JE (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd NE,MS E-86, Atlanta, GA 30333 USA. EM jkucik@cdc.gov NR 37 TC 18 Z9 18 U1 0 U2 12 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD JAN-FEB PY 2012 VL 127 IS 1 BP 52 EP 61 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 002DF UT WOS:000308510500006 PM 22298922 ER PT J AU Xu, X Chang, CC Lu, ML AF Xu, Xu Chang, Chien-Chi Lu, Ming-Lun TI Two linear regression models predicting cumulative dynamic L5/S1 joint moment during a range of lifting tasks based on static postures SO ERGONOMICS LA English DT Article DE manual materials handling; low back pain; cumulative L5/S1 moment; static moment ID LOW-BACK-PAIN; WORK-RELATEDNESS; SPINE; PEAK; LOAD; ORIENTATION; VALIDATION; EXPERIENCE; INDUSTRY; FORCES AB Previous studies have indicated that cumulative L5/S1 joint load is a potential risk factor for low back pain. The assessment of cumulative L5/S1 joint load during a field study is challenging due to the difficulty of continuously monitoring the dynamic joint load. This study proposes two regression models predicting cumulative dynamic L5/S1 joint moment based on the static L5/S1 joint moment of a lifting task at lift-off and set-down and the lift duration. Twelve men performed lifting tasks at varying lifting ranges and asymmetric angles in a laboratory environment. The cumulative L5/S1 joint moment was calculated from continuous dynamic L5/S1 moments as the reference for comparison. The static L5/S1 joint moments at lift-off and set-down were measured for the two regression models. The prediction error of the cumulative L5/S1 joint moment was 21 +/- 14 Nm x s (12% of the measured cumulative L5/S1 joint moment) and 14 +/- 9 Nm x s (8%) for the first and the second models, respectively. Practitioner Summary: The proposed regression models may provide a practical approach for predicting the cumulative dynamic L5/S1 joint loading of a lifting task for field studies since it requires only the lifting duration and the static moments at the lift-off and/or set-down instants of the lift. C1 [Xu, Xu; Chang, Chien-Chi] Liberty Mutual Res Inst Safety, Hopkinton, MA 01748 USA. [Lu, Ming-Lun] NIOSH, Cincinnati, OH 45226 USA. RP Chang, CC (reprint author), Liberty Mutual Res Inst Safety, 71 Frankland Rd, Hopkinton, MA 01748 USA. EM chien-chi.chang@libertymutual.com FU Intramural CDC HHS [CC999999] NR 39 TC 1 Z9 1 U1 1 U2 10 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0014-0139 J9 ERGONOMICS JI Ergonomics PY 2012 VL 55 IS 9 BP 1093 EP 1103 DI 10.1080/00140139.2012.693627 PG 11 WC Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Engineering; Psychology GA 996PO UT WOS:000308104400009 PM 22803616 ER PT J AU Livingston, SE Townshend-Bulson, LJ Bruden, DL McMahon, BJ Homan, CE Gove, JE Deubner, H Bruce, MG Robinson, RF Gretch, DR AF Livingston, Stephen E. Townshend-Bulson, Lisa J. Bruden, Dana L. McMahon, Brian J. Homan, Chriss E. Gove, James E. Deubner, Heike Bruce, Michael G. Robinson, Renee F. Gretch, David R. TI Treatment eligibility in Alaska Native and American Indian persons with hepatitis C virus infection SO INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH LA English DT Article DE hepatitis C treatment; hepatology clinics; treatment eligibility ID MANAGEMENT; DIAGNOSIS; CARE AB Objectives. Treatment with pegylated interferon and ribavirin may prevent progression of liver disease among patients with chronic hepatitis C virus infection (HCV). Treatment initiation is based on published clinical eligibility criteria, patients' willingness to undergo treatment and likelihood of success. We examined treatment eligibility in a cohort of Alaska Native and American Indian persons with chronic HCV infection. Study design. Retrospective cohort study. Methods. Medical records of all treatment naive HCV RNA positive patients given an appointment by hepatology specialty clinic staff in 2003 and 2007 were evaluated by a hepatology provider to investigate documented reasons for treatment deferral. Results. Treatment was initiated in 4 of 94 patients (4%) in 2003 and 14 of 146 patients (10%) in 2007. Major reasons for treatment deferral in 2003 versus 2007 included inconsistent appointment attendance (36% of deferrals vs. 18%), active substance abuse (17% vs. 22%), patient decision (17% vs. 27%), liver biopsy without fibrosis or normal ALT (8% vs. 3%), uncontrolled psychiatric condition (7% vs. 7%) and concurrent medical condition (6% vs. 9%). There was significant improvement in proportion of appointments attended in 2007 versus 2003 (76% vs. 67%, p = 0.04) and the percentage of patients attending at least 1 appointment (84% vs. 66%, p = 0.002). Conclusions. Multiple reasons for treatment deferral were documented. Despite a significant improvement in hepatology clinic attendance and an increase in the number of patients started on treatment in 2007 compared to 2003, the overall percentage of those treated remained low. C1 [Livingston, Stephen E.; Townshend-Bulson, Lisa J.; McMahon, Brian J.; Homan, Chriss E.; Gove, James E.] Alaska Native Tribal Hlth Consortium, Liver Dis & Hepatitis Program, Anchorage, AK 99508 USA. [Bruden, Dana L.; McMahon, Brian J.; Bruce, Michael G.] Ctr Dis Control & Prevent, Arctic Invest Program, Div Preparedness & Emerging Infect, Natl Ctr Emerging & Zoonot Infect Dis, Anchorage, AK USA. [Deubner, Heike] Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98195 USA. [Robinson, Renee F.] US PHS, Anchorage, AK USA. [Robinson, Renee F.] Southcent Fdn Res Dept, Anchorage, AK USA. [Gretch, David R.] Univ Washington, Sch Med, Dept Lab Med, Seattle, WA 98195 USA. RP Livingston, SE (reprint author), Alaska Native Tribal Hlth Consortium, Liver Dis & Hepatitis Program, 4315 Diplomacy Dr, Anchorage, AK 99508 USA. EM slivings@anthc.org FU University of Washington (Seattle, WA) National Institutes of Health [A48214, A1066209]; Alaska Native Tribal Health Consortium, Anchorage; Centers for Disease Control and Prevention, Anchorage, AK FX This study was supported by the University of Washington (Seattle, WA) National Institutes of Health Grant Nos. A48214 and A1066209, the Liver Disease and Hepatitis Program of the Alaska Native Tribal Health Consortium, Anchorage, and the Arctic Investigations Program of the Centers for Disease Control and Prevention, Anchorage, AK. We thank Brenna Simons, Ph.D., for helpful suggestions and careful review of this manuscript. NR 14 TC 2 Z9 2 U1 0 U2 1 PU CO-ACTION PUBLISHING PI JARFALLA PA RIPVAGEN 7, JARFALLA, SE-175 64, SWEDEN SN 1239-9736 J9 INT J CIRCUMPOL HEAL JI Int. J. Circumpolar Health PY 2012 VL 71 AR 18445 DI 10.3402/ijch.v71i0.18445 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 998IY UT WOS:000308232500001 PM 28156340 ER PT J AU Revich, B Tokarevich, N Parkinson, AJ AF Revich, Boris Tokarevich, Nikolai Parkinson, Alan J. TI Climate change and zoonotic infections in the Russian Arctic SO INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH LA English DT Review DE climate change; infectious diseases; tularemia; tick-borne encephalitis; brucellosis; rabies; anthrax; Russia; Arctic ID TICK-BORNE ENCEPHALITIS; IMPACT; NORTH AB Climate change in the Russian Arctic is more pronounced than in any other part of the country. Between 1955 and 2000, the annual average air temperature in the Russian North increased by 1.2 degrees C. During the same period, the mean temperature of upper layer of permafrost increased by 3 degrees C. Climate change in Russian Arctic increases the risks of the emergence of zoonotic infectious diseases. This review presents data on morbidity rates among people, domestic animals and wildlife in the Russian Arctic, focusing on the potential climate related emergence of such diseases as tick-borne encephalitis, tularemia, brucellosis, leptospirosis, rabies, and anthrax. C1 [Revich, Boris] Russian Acad Sci, Inst Forecasting, Moscow, Russia. [Tokarevich, Nikolai] Paster Inst Epidemiol & Microbiol, St Petersburg, Russia. [Parkinson, Alan J.] Ctr Dis Control & Prevent, Arctic Invest Program, Div Preparedness & Emerging Infect, Natl Ctr Emerging & Zoonot Infect Dis, Anchorage, AK USA. RP Revich, B (reprint author), Nachimovsky Av 47, Moscow 117418, Russia. EM revich@ecfor.ru RI Tokarevich, Nikolay/H-1877-2012 OI Tokarevich, Nikolay/0000-0001-6433-3486 NR 64 TC 16 Z9 17 U1 11 U2 42 PU CO-ACTION PUBLISHING PI JARFALLA PA RIPVAGEN 7, JARFALLA, SE-175 64, SWEDEN SN 1239-9736 EI 2242-3982 J9 INT J CIRCUMPOL HEAL JI Int. J. Circumpolar Health PY 2012 VL 71 AR 18792 DI 10.3402/ijch.v71i0.18792 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 998KK UT WOS:000308237300002 PM 22868189 ER PT J AU Cunningham, TR Geller, ES AF Cunningham, Thomas R. Geller, E. Scott TI A Comprehensive Approach to Identifying Intervention Targets for Patient-Safety Improvement in a Hospital Setting SO JOURNAL OF ORGANIZATIONAL BEHAVIOR MANAGEMENT LA English DT Article DE patient safety; medical error; Organizational Behavior Management ID ORGANIZATIONAL-BEHAVIOR MANAGEMENT; PERFORMANCE FEEDBACK; NEED AB Despite differences in approaches to organizational problem solving, healthcare managers and organizational behavior management (OBM) practitioners share a number of practices, and connecting healthcare management with OBM may lead to improvements in patient safety. A broad needs-assessment methodology was applied to identify patient-safety intervention targets in a large rural medical center. This included a content analysis of descriptions of managers' follow-up actions to error reports for nine types of the most frequently occurring errors. Follow-up actions were coded according to the taxonomy of behavioral intervention components developed by Geller et al. (1990). Two error types were identified as targets for intervention, and the outcome of this assessment process indicated a clear need to apply OBM interventions at the management level and thus have a hospital-wide benefit to patient safety. Future implications for using a system-wide approach to identifying and classifying responses to medical error are discussed. C1 [Cunningham, Thomas R.; Geller, E. Scott] Virginia Polytech Inst & State Univ, Blacksburg, VA 24061 USA. RP Cunningham, TR (reprint author), NIOSH, 4676 Columbia Pkwy,MS C-10, Cincinnati, OH 45226 USA. EM tcunningham@cdc.gov NR 40 TC 1 Z9 1 U1 0 U2 2 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0160-8061 J9 J ORGAN BEHAV MANAGE JI J. Organ. Behav. Manage. PY 2012 VL 32 IS 3 BP 194 EP 220 DI 10.1080/01608061.2012.698114 PG 27 WC Psychology, Applied; Management SC Psychology; Business & Economics GA 998NA UT WOS:000308245400003 ER PT J AU Al-Nsour, M Zindah, M Belbeisi, A Hadaddin, R Brown, DW Walke, H AF Al-Nsour, Mohannad Zindah, Meyasser Belbeisi, Adel Hadaddin, Raja Brown, David W. Walke, Henry TI Prevalence of Selected Chronic, Noncommunicable Disease Risk Factors in Jordan: Results of the 2007 Jordan Behavioral Risk Factor Surveillance Survey SO PREVENTING CHRONIC DISEASE LA English DT Article ID DIABETES-MELLITUS; WEIGHT-GAIN; PREVENTION AB Introduction Noncommunicable diseases (NCDs) are the leading cause of illness and death in Jordan. Since 2002, the Jordan Ministry of Health, in cooperation with the World Health Organization and the Centers for Disease Control and Prevention, established the Jordan Behavioral Risk Factor Surveillance Survey to collect information on many of the behaviors and conditions related to NCDs. The objectives of this study were to describe the prevalence of selected NCD risk factors and the relationship between body mass index and selected health conditions among a nationally representative sample of Jordanian adults aged 18 years or older. Methods We used a multistage sampling design to select 3,688 households, from which we randomly selected and interviewed 1 adult aged 18 years or older. A total of 3,654 adults completed the survey. We randomly selected a subsample of 889 interviewed adults and invited them to visit local health clinics for a medical evaluation; we obtained measurements, including fasting blood glucose and blood lipids, from 765 adults. Data were collected between June 1, 2007, and August 23, 2007. Results Nearly one-third of participants smoked cigarettes, 18% reported having been diagnosed with high blood pressure, and 10% reported frequent mental distress. Compared with survey participants who did not participate in the medical evaluation, those who participated were more likely to self-report high blood pressure, high blood cholesterol, and diabetes and report lower levels of health-related quality of life. Among participants of the medical evaluation, an estimated 11% reported they had been diagnosed with diabetes by a health professional, and 19% were diagnosed with diabetes according to laboratory testing. Approximately one-third of participants of the medical evaluation were either overweight (30%) or obese (36%). In the fully adjusted model, obese participants of the medical evaluation were nearly 3 times as likely to have high blood pressure and more than 2 times as likely to have high blood cholesterol as normal-weight participants. Conclusion Diabetes, high blood pressure, high cholesterol, and obesity are a public health concern in Jordan. Adequate and continuous monitoring of NCD risk factors in Jordan is needed, and the surveillance findings should be used in health promotion and disease prevention activities. C1 [Al-Nsour, Mohannad; Zindah, Meyasser; Belbeisi, Adel; Hadaddin, Raja] Minist Hlth, Amman 11196, Jordan. [Brown, David W.] Brown Consulting Grp, Charlotte, NC USA. [Walke, Henry] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Al-Nsour, M (reprint author), Minist Hlth, Dahiyat Al Rasheed Alwifaq St,Bldg 94,1st Floor,O, Amman 11196, Jordan. EM mohannadnsour973@yahoo.com NR 20 TC 5 Z9 5 U1 1 U2 6 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD JAN PY 2012 VL 9 AR 110077 DI 10.5888/pcd9.110077 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 977GI UT WOS:000306644300025 ER PT J AU Barfield, WD Warner, L AF Barfield, Wanda D. Warner, Lee TI Preventing Chronic Disease in Women of Reproductive Age: Opportunities for Health Promotion and Preventive Services SO PREVENTING CHRONIC DISEASE LA English DT Editorial Material ID UNITED-STATES; RISK-FACTORS; PREGNANCY; DEPRESSION; SYSTEM C1 [Barfield, Wanda D.; Warner, Lee] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Warner, L (reprint author), Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,Mailstop K20, Atlanta, GA 30341 USA. EM dlw7@cdc.gov NR 17 TC 1 Z9 1 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD JAN PY 2012 VL 9 AR 110281 DI 10.5888/pcd9.110281 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 977GI UT WOS:000306644300034 ER PT J AU Herman, E Garbe, P AF Herman, Elizabeth Garbe, Paul TI Evidence-Based Health: Necessary But Not Sufficient SO PREVENTING CHRONIC DISEASE LA English DT Letter ID ASTHMA C1 [Herman, Elizabeth; Garbe, Paul] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Air Pollut & Resp Hlth Branch, Atlanta, GA USA. RP Herman, E (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Air Pollut & Resp Hlth Branch, Atlanta, GA USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD JAN PY 2012 VL 9 AR 110304 DI 10.5888/pcd9.110304 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 977GI UT WOS:000306644300028 ER PT J AU Lanier, WA Wagstaff, RS DeMill, JH Friedrichs, MD Metos, J AF Lanier, William A. Wagstaff, Rachelle S. DeMill, Jessica H. Friedrichs, Michael D. Metos, Julie TI Teacher Awareness and Implementation of Food and Physical Activity Policies in Utah Elementary Schools, 2010 SO PREVENTING CHRONIC DISEASE LA English DT Article ID CORONARY-HEART-DISEASE; WELLNESS POLICY; HEALTH POLICIES; PUBLIC-SCHOOLS; NUTRITION; IMPACT; OVERWEIGHT; EDUCATION; PROGRAMS; OBESITY AB Introduction Schools are a key venue for childhood obesity prevention policies. The objective of this study was to examine factors associated with elementary school teacher awareness and implementation of their schools' food and physical activity policies. Methods We collected data through an online survey of teachers at Utah elementary schools with food and physical activity policies. We used bivariate analysis and logistic regression to assess association of variables with teacher awareness and implementation. Results Of 1,243 teacher respondents, 546 (44%) were aware of the food policy and 550 (44%) were aware of the physical activity policy. Food policy awareness was associated with knowing where written policies were located (odds ratio [OR], 2.7; 95% confidence interval [CI], 2.0-3.5), knowing the school health program coordinator (OR, 1.9; 95% CI, 1.4-2.7), and being reminded of policies at least once per semester (OR, 2.3; 95% CI, 1.7-2.9). Policy awareness was associated with both food (OR, 4.6; 95% CI, 3.6-6.0) and physical activity (OR, 1.6, 95% CI, 1.2-2.3) policy implementation. Helping develop the physical activity policy was associated with its implementation (OR, 2.4; 95% CI, 1.2-4.7). Thinking that students were more overweight than in the past was associated with food policy implementation (OR, 1.6; 95% CI, 1.1-2.5). Conclusion Establishing food and physical activity policies at schools does not ensure teacher awareness or implementation. To promote policy awareness and implementation, school leaders should involve teachers in policy development, remind teachers of policies at least once per semester, and continue to educate teachers about childhood obesity. C1 [Lanier, William A.] Utah Dept Hlth, EIS, Salt Lake City, UT 84116 USA. [Lanier, William A.; Metos, Julie] Univ Utah, Salt Lake City, UT USA. [Lanier, William A.] Ctr Dis Control & Prevent, EIS Field Assignments Branch, Atlanta, GA USA. RP Lanier, WA (reprint author), US FDA, Ctr Food Safety & Appl Nutr, 5100 Paint Branch Pkwy, College Pk, MD 20740 USA. EM william.lanier@fda.hhs.gov FU Utah Department of Health; CDC, Division of Nutrition and Physical Activity [U58/DP001386] FX This study was funded through a Utah Department of Health Cooperative Agreement with CDC, Division of Nutrition and Physical Activity (no. U58/DP001386). We thank Sarah Rigby, Lynda Blades, MPH, Nicole Bissonette, MPH, Heather R. Borski, MPH, and Kathryn Clark at the Utah Department of Health for their assistance with the study. NR 28 TC 1 Z9 1 U1 3 U2 10 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD JAN PY 2012 VL 9 AR 110091 DI 10.5888/pcd9.110091 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 977GI UT WOS:000306644300018 ER PT J AU Zlot, AI Silvey, K Newell, N Coates, RJ Leman, R AF Zlot, Amy I. Silvey, Kerry Newell, Nanette Coates, Ralph J. Leman, Richard TI Family History of Colorectal Cancer: Clinicians' Preventive Recommendations and Patient Behavior SO PREVENTING CHRONIC DISEASE LA English DT Article ID ADENOMATOUS POLYPS; INCREASED RISK; PRIMARY-CARE; LIFE-STYLES; TASK-FORCE; SURVEILLANCE; METAANALYSIS; ACCURACY; DISEASES; SYSTEM AB Few population-based studies have addressed the role that family history of colorectal cancer (CRC) plays in clinician decision making or patient health choices. The objective of this study was to evaluate the effect of family history of CRC on clinician practice, patient CRC screening, and patient preventive behavior. We analyzed 2008 Oregon Behavioral Risk Factor Surveillance System data to examine associations between family history of CRC and 1) patient-reported clinician recommendations, 2) perceived risk of developing CRC, 3) adoption of preventive and screening behaviors, and 4) CRC risk factors among 1,795 respondents without CRC. A family history of CRC was positively associated with a higher likelihood of respondents reporting that their clinicians discussed colorectal cancer screening (OR, 4.2; 95% CI, 2.4-7.4) and of respondents having colorectal screening within the recommended time period (OR, 2.2; 95% CI, 1.3-3.9). A family history of CRC was also associated with respondents reporting lifestyle changes to prevent CRC (OR, 2.6; 95% CI, 1.7-4.0). A family history of CRC may prompt clinicians to recommend screening and preventive behavior changes and motivate patients to adopt such strategies. C1 [Zlot, Amy I.] Oregon Hlth Author, Genet Program, Publ Hlth Div, Portland, OR 97232 USA. [Silvey, Kerry] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Coates, Ralph J.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Zlot, AI (reprint author), Oregon Hlth Author, Genet Program, Publ Hlth Div, 800 NE Oregon St,Ste 805, Portland, OR 97232 USA. EM amy.zlot@state.or.us FU Centers for Disease Control and Prevention (CDC) [CDC-RFAGD08-801, 1U38GD000061] FX This project was supported by the Centers for Disease Control and Prevention (CDC) Cooperative agreement no. CDC-RFAGD08-801 ( grant no. 1U38GD000061). NR 28 TC 4 Z9 4 U1 0 U2 2 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD JAN PY 2012 VL 9 AR 100254 DI 10.5888/pcd9.100254 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 977GI UT WOS:000306644300021 ER PT J AU Iavicoli, I Schulte, PA Iavicoli, S AF Iavicoli, Ivo Schulte, Paul A. Iavicoli, Sergio TI Nanomaterial Interactions with Biological Systems: Implications for Occupational Health SO JOURNAL OF NANOMATERIALS LA English DT Editorial Material C1 [Iavicoli, Ivo] Univ Cattolica Sacro Cuore, Inst Occupat Med, I-00168 Rome, Italy. [Schulte, Paul A.] Ctr Dis Control & Prevent, NIOSH, Atlanta, GA 30333 USA. [Iavicoli, Sergio] Italian Workers Compensat Author INAIL, Dept Occupat Med, I-00198 Rome, Italy. RP Iavicoli, I (reprint author), Univ Cattolica Sacro Cuore, Inst Occupat Med, I-00168 Rome, Italy. EM iavicoli.ivo@rm.unicatt.it RI Iavicoli, Ivo/K-9062-2016; OI Iavicoli, Ivo/0000-0003-0444-3792; Iavicoli, Sergio/0000-0002-5956-9723 NR 0 TC 0 Z9 0 U1 0 U2 5 PU HINDAWI PUBLISHING CORPORATION PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 1687-4110 J9 J NANOMATER JI J. Nanomater. PY 2012 AR 230728 DI 10.1155/2012/230728 PG 2 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA 998FI UT WOS:000308222400001 ER PT J AU Tsai, KD Lin, JC Yang, SM Tseng, MJ Hsu, JD Lee, YJ Cherng, JM AF Tsai, Kuen-Daw Lin, Jung-Chung Yang, Shu-mei Tseng, Min-Jen Hsu, Jeng-Dong Lee, Yi-Ju Cherng, Jaw-Ming TI Curcumin Protects against UVB-Induced Skin Cancers in SKH-1 Hairless Mouse: Analysis of Early Molecular Markers in Carcinogenesis SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE LA English DT Article ID KAPPA-B ACTIVATION; NITRIC-OXIDE; OXIDATIVE STRESS; DIETARY CURCUMIN; CELLS; EXPRESSION; RADIATION; INHIBITION; COX-2; EPIDERMIS AB Curcumin (CUR) has been shown to possess a preventive effect against various cancers and interfere with multiple-cell signaling pathways. We evaluated the protective effects of CUR in regression of UVB-induced skin tumor formation in SKH-1 hairless mice and its underlying early molecular biomarkers associated with carcinogenesis. Mice irradiated with UVB at 180 mJ/cm(2) twice per week elicited 100% tumor incidence at 20 weeks. Topical application of CUR prior to UVB irradiation caused delay in tumor appearance, multiplicity, and size. Topical application of CUR prior to and immediately after a single UVB irradiation (180 mJ/cm(2)) resulted in a significant decrease in UVB-induced thymine dimer-positive cells, expression of proliferative cell nuclear antigen (PCNA), terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling, and apoptotic sunburn cells together with an increase in p53 and p21/Cip1-positive cell population in epidermis. Simultaneously, CUR also significantly inhibited NF-kappa B, cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), and nitric oxide (NO) levels. The results suggest that the protective effect of CUR against photocarcinogenesis is accompanied by downregulation of cell proliferative controls, involving thymine dimer, PCNA, apoptosis, transcription factors NF-kappa B, and of inflammatory responses involving COX-2, PGE2, and NO, while upregulation of p53 and p21/Cip1 to prevent DNA damage and facilitate DNA repair. C1 [Cherng, Jaw-Ming] Chung Shan Med Univ Hosp, Dept Internal Med, Taichung 402, Taiwan. [Cherng, Jaw-Ming] Chung Shan Med Univ, Taichung 402, Taiwan. [Tsai, Kuen-Daw; Yang, Shu-mei] China Med Univ, Dept Internal Med, Beigang Hosp, Yunlin 651, Taiwan. [Tsai, Kuen-Daw; Yang, Shu-mei] China Med Univ, Sch Chinese Med, Coll Chinese Med, Taichung 404, Taiwan. [Tsai, Kuen-Daw; Tseng, Min-Jen] Natl Chung Cheng Univ, Inst Mol Biol, Dept Life Sci, Chiayi 621, Taiwan. [Lin, Jung-Chung] Ctr Dis Control & Prevent, Div Viral Hepatitis, Cellular Virol Unit, Atlanta, GA 30333 USA. [Hsu, Jeng-Dong; Lee, Yi-Ju] Chung Shan Med Univ Hosp, Dept Pathol, Taichung 402, Taiwan. [Hsu, Jeng-Dong; Lee, Yi-Ju] Chung Shan Med Univ, Taichung 402, Taiwan. RP Cherng, JM (reprint author), Chung Shan Med Univ Hosp, Dept Internal Med, 110 Jianguo N Rd,Sec 1, Taichung 402, Taiwan. EM happy.professor@yahoo.com FU National Science Council (NSC) of Taiwan [97-2320-B-040-033-MY3]; China Medical University Beigang Hospital FX This work was supported in part by grants from the National Science Council (NSC) of Taiwan (97-2320-B-040-033-MY3) and China Medical University Beigang Hospital. NR 30 TC 10 Z9 10 U1 1 U2 1 PU HINDAWI PUBLISHING CORPORATION PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 1741-427X J9 EVID-BASED COMPL ALT JI Evid.-based Complement Altern. Med. PY 2012 AR 593952 DI 10.1155/2012/593952 PG 11 WC Integrative & Complementary Medicine SC Integrative & Complementary Medicine GA 989PY UT WOS:000307573900001 ER PT J AU Owusu-Edusei, K Doshi, SR AF Owusu-Edusei, Kwame, Jr. Doshi, Sonal R. TI Assessing spatial gaps in sexually transmissible infection services and morbidity: an illustration with Texas county-level data from 2007 SO SEXUAL HEALTH LA English DT Article DE family planning clinic; geographic information systems; STI service location; spatial analysis; Texas ID GEOGRAPHIC INFORMATION-SYSTEM; TRANSMITTED-DISEASES; SAN-FRANCISCO; GONORRHEA; CHLAMYDIA; CLINICS; CARE; ISSUES; CORE AB Background: In the United States, sexually transmissible infection (STI) and family planning (FP) clinics play a major role in the detection and treatment of STIs. However, an examination of the spatial distribution of these service sites and their association with STI morbidity and county-level socioeconomic characteristics is lacking. We demonstrate how mapping and regression methods can be used to assess the spatial gaps between STI services and morbidity. Methods: We used 2007 county-level surveillance data on chlamydia (Chlamydia trachomatis), gonorrhoea (Neisseria gonorrhoeae) and syphilis. The geocoded STI service (STI or FP clinic) locations overlaid on the Texas county-level chlamydia, gonorrhoea and syphilis morbidity map indicated that counties with high incidence had at least one STI service site. Logistic regression was used to examine the association between having STI services and county-level socioeconomic characteristics. Results: Twenty-two percent of chlamydia high-morbidity counties (>365 out of 100 000); 32% of gonorrhoea high-morbidity counties (>136 out of 100 000) and 23% of syphilis high-morbidity counties (>= 4 out of 100 000 and at least two cases) had no STI services. When we controlled for socioeconomic characteristics, high-morbidity syphilis was weakly associated with having STI services. The percent of the population aged 15-24 years, the percent of Hispanic population, the crime rate and population density were significantly (P < 0.05) associated with having STI services. Conclusion: Our results suggest that having an STI service was not associated with high morbidity. The methods used have demonstrated the utility of mapping to assess the spatial gaps that exist between STI services and demand. C1 [Owusu-Edusei, Kwame, Jr.; Doshi, Sonal R.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30333 USA. RP Owusu-Edusei, K (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30333 USA. EM Kowusuedusei@cdc.gov NR 22 TC 2 Z9 2 U1 0 U2 3 PU CSIRO PUBLISHING PI COLLINGWOOD PA 150 OXFORD ST, PO BOX 1139, COLLINGWOOD, VICTORIA 3066, AUSTRALIA SN 1448-5028 J9 SEX HEALTH JI Sex Health PY 2012 VL 9 IS 4 BP 334 EP 340 DI 10.1071/SH11117 PG 7 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 987IJ UT WOS:000307410100006 PM 22877592 ER PT J AU Hanley, KW Viet, SM Hein, MJ Carreon, T Ruder, AM AF Hanley, Kevin W. Viet, Susan M. Hein, Misty J. Carreon, Tania Ruder, Avima M. TI Exposure to o-Toluidine, Aniline, and Nitrobenzene in a Rubber Chemical Manufacturing Plant: A Retrospective Exposure Assessment Update SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE aniline; bladder cancer; job-exposure matrix; nitrobenzene; occupational epidemiology; ortho-toluidine; retrospective exposure assessment ID AROMATIC-AMINES; BLADDER-CANCER; WORKERS; MORTALITY; INDUSTRY; ADDUCTS; EXCESS; SKIN AB The National Institute for Occupational Safety and Health previously conducted a retrospective cancer incidence and mortality study of workers employed at a rubber chemical manufacturing plant. Compared with New York State incidence, the bladder cancer risk was 6.5 times higher for workers considered to have definite exposure to ortho-toluidine and aniline, and 4 times higher for workers with possible exposure. Exposure characterization in the original study utilized a surrogate measure based only on departments in which each worker was ever employed. As part of an update of that study, some departments in the three original exposure groups were reclassified based on a follow-up site visit; interviews with employees, management, and union representatives; and review of records including exposure data. An additional evaluation of department-job combinations, rather than only departments, was used to stratify exposure into four categories. An approximate rank of "relative" exposure level for each department-job-year combination was also assigned using a ranking scale of 0 to 10. The ranks were supported by quantitative exposure levels and by professional judgment. The numerical ranking scale was applied to each worker by multiplying the exposure rank by duration for each job held based on comprehensive individual work histories. The cumulative rank scores for this cohort ranged from 0 to 300 unit-years. The medians of the cumulative rank scores for the exposure categories showed very good agreement with increasing exposure classifications (e. g., 0.72, 4.6, 11, 14 unit-years for the four exposure categories). Workers' breathing zone air sampling data collected at this plant from 1976-2004 were well below published occupational exposure limits for these chemicals, but additional cases of bladder cancer have been reported. The exposure assessment revisions and rank estimates will be used to analyze the updated bladder cancer incidence data. C1 [Hanley, Kevin W.; Hein, Misty J.; Carreon, Tania; Ruder, Avima M.] NIOSH, Ind Studies Branch, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH 45226 USA. [Viet, Susan M.] Westat Corp, Rockville, MD USA. RP Hanley, KW (reprint author), NIOSH, Ind Studies Branch, Div Surveillance Hazard Evaluat & Field Studies, 4676 Columbia Pkwy,MS R-14, Cincinnati, OH 45226 USA. EM khanley@cdc.gov RI Ruder, Avima/I-4155-2012 OI Ruder, Avima/0000-0003-0419-6664 NR 30 TC 2 Z9 3 U1 0 U2 5 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1545-9624 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2012 VL 9 IS 8 BP 478 EP 490 DI 10.1080/15459624.2012.693836 PG 13 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 976RT UT WOS:000306602700004 PM 22708702 ER PT J AU Arowojolu, AO Gallo, MF Lopez, LM Grimes, DA AF Arowojolu, Ayodele O. Gallo, Maria F. Lopez, Laureen M. Grimes, David A. TI Combined oral contraceptive pills for treatment of acne SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS LA English DT Review DE Acne Vulgaris [drug therapy]; Contraceptives, Oral, Combined [therapeutic use]; Randomized Controlled Trials as Topic; Female; Humans ID PLACEBO-CONTROLLED TRIAL; 20 MU-G; CYPROTERONE-ACETATE TREATMENT; RANDOMIZED CONTROLLED-TRIAL; PHASE-III TRIAL; ETHINYL ESTRADIOL; DOUBLE-BLIND; MODERATE ACNE; 24/4 REGIMEN; IN-VITRO AB Background Acne is a common skin disorder among women. Although no uniform approach to the management of acne exists, combination oral contraceptives (COCs), which contain an estrogen and a progestin, often are prescribed for women. Objectives To determine the effectiveness of combined oral contraceptives (COCs) for the treatment of facial acne compared to placebo or other active therapies. Search methods In January 2012, we searched for randomized controlled trials of COCs and acne in the computerized databases of the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, POPLINE, and LILACS. We also searched for clinical trials in ClinicalTrials. gov and the International Clinical Trials Registry Platform (ICTRP) (Aug 2011). For the initial review, we wrote to researchers to seek any unpublished or published trials that we might have missed. Selection criteria We considered randomized controlled trials reported in any language that compared the effectiveness of a COC containing an estrogen and a progestin to placebo or another active therapy for acne in women. Data collection and analysis We extracted data on facial lesion counts, both total and specific (i.e., open or closed comedones, papules, pustules and nodules); acne severity grades; global assessments by the clinician or the participant, and discontinuation due to adverse events. Data were entered and analyzed in RevMan. For continuous data, we calculated themean difference (MD) and 95% confidence interval (CI). For dichotomous data, we calculated the Peto odds ratio (OR) and 95% CI. Main results The review includes 31 trials with 12,579 participants. Of 24 comparisons made, 6 compared a COC to placebo, 17 different COCs, and 1 compared a COC to an antibiotic. Of nine placebo-controlled trials with data for analysis, all showed COCs reduced acne lesion counts, severity grades and self-assessed acne compared to placebo. A levonorgestrel-COC group had fewer total lesion counts (MD 9.98; 95% CI -16.51 to -3.45), inflammatory and non-inflammatory lesion counts, and were more likely to have a clinician assessment of clear or almost clear lesions and participant self-assessment of improved acne lesions. A norethindrone acetate COC had better results for clinician global assessment of no acne to mild acne (OR 1.86; 95% CI 1.32 to 2.62). In two combined trials, a norgestimate COC showed reduced total lesion counts (MD-9.32; 95% CI -14.19 to -4.45), reduced inflammatory lesion and comedones counts, and more with clinician assessment of improved acne. For two combined trials of a drospirenone COC, the investigators' assessment of clear or almost clear skin favored the drospirenone group (OR 3.02; 95% CI 1.99 to 4.59). In one trial, the drospirenone-COC group showed greater (more positive) percent changes for total lesion count (MD 29.08; 95% CI 3.13 to 55.03), inflammatory and non-inflammatory lesion counts, and papule and closed comedone counts. A dienogest-COC group had greater percentage decreases in total lesion count (MD -15.30; 95% CI -19.98 to -10.62) and inflammatory lesion count, and more women assessed with overall improvement of facial acne. A CMA-COC group had more 'responders,' those with 50% or greater decrease in facial papules and pustules (OR 2.31; 95% CI 1.50 to 3.55) Differences in the comparative effectiveness of COCs containing varying progestin types and dosages were less clear, and data were limited for any particular comparison. COCs that contained chlormadinone acetate or cyproterone acetate improved acne better than levonorgestrel. A COC with cyproterone acetate showed better acne outcomes than one with desogestrel, but the studies produced conflicting results. Likewise, levonorgestrel showed a slight improvement over desogestrel in acne outcomes, but results were not consistent. A drospirenone COC appeared to be more effective than norgestimate or nomegestrol acetate plus 17 beta-estradiol but less effective than cyproterone acetate. Authors' conclusions This update yielded six new trials but no change in conclusions. The six COCs evaluated in placebo-controlled trials are effective in reducing inflammatory and non-inflammatory facial acne lesions. Few important and consistent differences were found between COC types in their effectiveness for treating acne. How COCs compare to alternative acne treatments is unknown since only one trial addressed this issue. The use of standardized methods for assessing acne severity would help in synthesizing results across trials as well as aid in interpretation. C1 [Arowojolu, Ayodele O.] Univ Coll Ibadan Hosp, Dept Obstet & Gynaecol, Coll Med, Ibadan, Oyo State, Nigeria. [Gallo, Maria F.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA. [Grimes, David A.] Univ N Carolina, Sch Med, Chapel Hill, NC USA. [Lopez, Laureen M.] Clin Sci, FHI 360, Res Triangle Pk, NC USA. RP Arowojolu, AO (reprint author), Univ Coll Ibadan Hosp, Dept Obstet & Gynaecol, Coll Med, Ibadan, Oyo State, Nigeria. EM ayo_arowojolu@yahoo.com FU National Institute of Child Health and Human Development, USA; US Agency for International Development, USA FX External sources; National Institute of Child Health and Human Development, USA.; US Agency for International Development, USA. NR 89 TC 0 Z9 0 U1 1 U2 14 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1469-493X J9 COCHRANE DB SYST REV JI Cochrane Database Syst Rev. PY 2012 IS 6 AR CD004425 DI 10.1002/14651858.CD004425.pub5 PG 122 WC Medicine, General & Internal SC General & Internal Medicine GA 957VC UT WOS:000305192400031 ER PT J AU Tieu, HV Spikes, P Patterson, J Bonner, S Egan, JE Goodman, K Stewart, K Frye, V Xu, GZ Hoover, DR Koblin, BA AF Tieu, Hong-Van Spikes, Pilgrim Patterson, Jocelyn Bonner, Sebastian Egan, James E. Goodman, Krista Stewart, Kiwan Frye, Victoria Xu, Guozhen Hoover, Donald R. Koblin, Beryl A. TI Sociodemographic and risk behavior characteristics associated with unprotected sex with women among black men who have sex with men and women in New York City SO AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV LA English DT Article DE black MSMW; men who have sex with men and women; bisexuality; HIV/AIDS ID AFRICAN-AMERICAN; HIV-INFECTION; UNITED-STATES; BISEXUAL MEN; LOS-ANGELES; WHITE MEN; DISCLOSURE; TRANSMISSION; DISPARITIES; PREDICTORS AB The objectives of this cross-sectional study were to compare sociodemographic and risk behavior characteristics between black men who have sex with both men and women (MSMW) and those who have sex with men only (MSMO) and assess factors associated with having any unprotected vaginal and/or anal intercourse (UVAI) with women in the last 3 months. Data from 326 black men who reported recent unprotected anal intercourse with a man in an HIV behavioral intervention study in New York City were analyzed. Baseline characteristics were compared between MSMW and MSMO, and factors associated with having any UVAI in the past 3 months with women among MSMW were evaluated. In total, 26.8% reported having sex with both men and women in the last 3 months. MSMW were less likely to be HIV infected, use amyl nitrates, and have unprotected receptive anal sex with most recent male partner. MSMW were more likely to be over 40 years old and use heroin. A total of 55.6% of MSMW reported having UVAI with women in the last 3 months. Compared to MSMW having only protected sex, MSMW having any UVAI with women were less likely to be HIV infected and to disclose having sex with men to female partners; they were more likely to have greater than four male sex partners in the last 3 months. In conclusion, HIV prevention interventions among black MSMW should directly address the risk of HIV transmission to both their female and male partners. Disclosure of bisexuality to female partners may be an important component of future prevention efforts. C1 [Tieu, Hong-Van; Goodman, Krista; Stewart, Kiwan; Xu, Guozhen; Koblin, Beryl A.] New York Blood Ctr, Lindsley F Kimball Res Inst, Lab Infect Dis Prevent, New York, NY 10021 USA. [Tieu, Hong-Van] Columbia Univ Coll Phys & Surg, Dept Med, Div Infect Dis, New York, NY 10032 USA. [Spikes, Pilgrim; Patterson, Jocelyn] Ctr Dis Control & Prevent, Atlanta, GA USA. [Bonner, Sebastian] New York Acad Med, New York, NY USA. [Egan, James E.] Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA. [Frye, Victoria] New York Blood Ctr, Lindsley F Kimball Res Inst, Lab Social & Behav Sci, New York, NY 10021 USA. [Hoover, Donald R.] Rutgers State Univ, Dept Stat, Rutgers, NJ USA. RP Tieu, HV (reprint author), New York Blood Ctr, Lindsley F Kimball Res Inst, Lab Infect Dis Prevent, New York, NY 10021 USA. EM htieu@nybloodcenter.org FU NCHHSTP CDC HHS [UR6 PS000437, 3UR6PS000437-03W1]; NIDA NIH HHS [K01 DA031035, K01 DA 031035] NR 27 TC 8 Z9 9 U1 1 U2 4 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0954-0121 J9 AIDS CARE JI Aids Care-Psychol. Socio-Med. Asp. Aids-Hiv PY 2012 VL 24 IS 9 BP 1111 EP 1119 DI 10.1080/09540121.2012.672723 PG 9 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychology, Multidisciplinary; Respiratory System; Social Sciences, Biomedical SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychology; Respiratory System; Biomedical Social Sciences GA 975FJ UT WOS:000306492700008 PM 22533637 ER PT J AU Arowojolu, AO Gallo, MF Lopez, LM Grimes, DA AF Arowojolu, Ayodele O. Gallo, Maria F. Lopez, Laureen M. Grimes, David A. TI Combined oral contraceptive pills for treatment of acne SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS LA English DT Review DE Acne Vulgaris [drug therapy]; Contraceptives, Oral, Combined [therapeutic use]; Randomized Controlled Trials as Topic; Female; Humans ID PLACEBO-CONTROLLED TRIAL; 20 MU-G; CYPROTERONE-ACETATE TREATMENT; RANDOMIZED CONTROLLED-TRIAL; PHASE-III TRIAL; ETHINYL ESTRADIOL; DOUBLE-BLIND; MODERATE ACNE; 24/4 REGIMEN; IN-VITRO AB Background Acne is a common skin disorder among women. Although no uniform approach to the management of acne exists, combination oral contraceptives (COCs), which contain an estrogen and a progestin, often are prescribed for women. Objectives To determine the effectiveness of combined oral contraceptives (COCs) for the treatment of facial acne compared to placebo or other active therapies. Search methods In January 2012, we searched for randomized controlled trials of COCs and acne in the computerized databases of the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, POPLINE, and LILACS. We also searched for clinical trials in ClinicalTrials.gov and the International Clinical Trials Registry Platform (ICTRP) (Aug 2011). For the initial review, we wrote to researchers to seek any unpublished or published trials that we might have missed. Selection criteria We considered randomized controlled trials reported in any language that compared the effectiveness of a COC containing an estrogen and a progestin to placebo or another active therapy for acne in women. Data collection and analysis We extracted data on facial lesion counts, both total and specific (i.e., open or closed comedones, papules, pustules and nodules); acne severity grades; global assessments by the clinician or the participant, and discontinuation due to adverse events. Data were entered and analyzed in RevMan. For continuous data, we calculated the mean difference (MD) and 95% confidence interval (CI). For dichotomous data, we calculated the Peto odds ratio (OR) and 95% CI. Main results The review includes 31 trials with 12,579 participants. Of 24 comparisons made, 6 compared a COC to placebo, 17 different COCs, and 1 compared a COC to an antibiotic. Of nine placebo-controlled trials with data for analysis, all showed COCs reduced acne lesion counts, severity grades and self-assessed acne compared to placebo. A levonorgestrel-COC group had fewer total lesion counts (MD 9.98; 95% CI -16.51 to -3.45), inflammatory and non-inflammatory lesion counts, and were more likely to have a clinician assessment of clear or almost clear lesions and participant self-assessment of improved acne lesions. A norethindrone acetate COC had better results for clinician global assessment of no acne to mild acne (OR 1.86; 95% CI 1.32 to 2.62). In two combined trials, a norgestimate COC showed reduced total lesion counts (MD-9.32; 95% CI -14.19 to -4.45), reduced inflammatory lesion and comedones counts, and more with clinician assessment of improved acne. For two combined trials of a drospirenone COC, the investigators' assessment of clear or almost clear skin favored the drospirenone group (OR 3.02; 95% CI 1.99 to 4.59). In one trial, the drospirenone-COC group showed greater (more positive) percent changes for total lesion count (MD 29.08; 95% CI 3.13 to 55.03), inflammatory and non-inflammatory lesion counts, and papule and closed comedone counts. A dienogest-COC group had greater percentage decreases in total lesion count (MD -15.30; 95% CI -19.98 to -10.62) and inflammatory lesion count, and more women assessed with overall improvement of facial acne. A CMA-COC group had more 'responders,' those with 50% or greater decrease in facial papules and pustules (OR 2.31; 95% CI 1.50 to 3.55) Differences in the comparative effectiveness of COCs containing varying progestin types and dosages were less clear, and data were limited for any particular comparison. COCs that contained chlormadinone acetate or cyproterone acetate improved acne better than levonorgestrel. A COC with cyproterone acetate showed better acne outcomes than one with desogestrel, but the studies produced conflicting results. Likewise, levonorgestrel showed a slight improvement over desogestrel in acne outcomes, but results were not consistent. A drospirenone COC appeared to be more effective than norgestimate or nomegestrol acetate plus 17 beta-estradiol but less effective than cyproterone acetate. Authors' conclusions This update yielded six new trials but no change in conclusions. The six COCs evaluated in placebo-controlled trials are effective in reducing inflammatory and non-inflammatory facial acne lesions. Few important and consistent differences were found between COC types in their effectiveness for treating acne. How COCs compare to alternative acne treatments is unknown since only one trial addressed this issue. The use of standardized methods for assessing acne severity would help in synthesizing results across trials as well as aid in interpretation. C1 [Arowojolu, Ayodele O.] Univ Coll Hosp, Coll Med, Dept Obstet & Gynaecol, Ibadan, Oyo State, Nigeria. [Gallo, Maria F.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA. [Lopez, Laureen M.] FHI 360, Clin Sci, Res Triangle Pk, NC USA. [Grimes, David A.] Univ N Carolina, Sch Med, Chapel Hill, NC USA. RP Arowojolu, AO (reprint author), Univ Coll Hosp, Coll Med, Dept Obstet & Gynaecol, Ibadan, Oyo State, Nigeria. EM ayo_arowojolu@yahoo.com FU National Institute of Child Health and Human Development, USA; US Agency for International Development, USA FX External sources; National Institute of Child Health and Human Development, USA.; US Agency for International Development, USA. NR 89 TC 2 Z9 2 U1 2 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1469-493X J9 COCHRANE DB SYST REV JI Cochrane Database Syst Rev. PY 2012 IS 7 AR CD004425 DI 10.1002/14651858.CD004425.pub6 PG 122 WC Medicine, General & Internal SC General & Internal Medicine GA 972ME UT WOS:000306280400017 ER PT J AU Frank, J Andrews, C Green, T Samuels, A Trinh, TT Friedmann, PD AF Frank, Joseph Andrews, Christina Green, Traci Samuels, Aaron Trinh, T. Tony Friedmann, Peter D. TI Emergency Department Use for Substance Use Conditions among Ex-Prisoners SO SUBSTANCE ABUSE LA English DT Meeting Abstract C1 [Frank, Joseph; Andrews, Christina; Green, Traci; Friedmann, Peter D.] Rhode Isl Hosp, Div Gen Internal Med, Providence, RI 02903 USA. [Samuels, Aaron] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30329 USA. [Trinh, T. Tony] Univ Washington, Div Infect Dis, Seattle, WA 98195 USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0889-7077 J9 SUBST ABUS JI Subst. Abus. PY 2012 VL 33 IS 2 BP 210 EP 210 PG 1 WC Substance Abuse SC Substance Abuse GA 974UZ UT WOS:000306464200044 ER PT J AU Sugerman, DE Keir, JM Dee, DL Lipman, H Waterman, SH Ginsberg, M AF Sugerman, David E. Keir, Jane M. Dee, Deborah L. Lipman, Harvey Waterman, Stephen H. Ginsberg, Michele TI Emergency Health Risk Communication During the 2007 San Diego Wildfires: Comprehension, Compliance, and Recall SO JOURNAL OF HEALTH COMMUNICATION LA English DT Article ID PANDEMIC INFLUENZA; DAILY MORTALITY; CALIFORNIA; POPULATIONS; POLLUTION AB In October 2007, wildfires burned nearly 300,000 acres in San Diego County, California. Emergency risk communication messages were broadcast to reduce community exposure to air pollution caused by the fires. The objective of this investigation was to determine residents' exposure to, understanding of, and compliance with these messages. From March to June 2008, the authors surveyed San Diego County residents using a 40-question instrument and random digit dialing. The 1,802 respondents sampled were predominantly 35-64 years old (65.9%), White (65.5%), and educated past high school (79.0%). Most (82.5%) lived more than 1 mile away from the fires, although many were exposed to smoky air for 5-7 days (60.7%) inside and outside their homes. Most persons surveyed reported hearing fire-related health messages (87.9%) and nearly all (97.9%) understood the messages they heard. Respondents complied with most to all of the nontechnical health messages, including staying inside the home (58.7%), avoiding outdoor exercise (88.4%), keeping windows and doors closed (75.8%), and wetting ash before cleanup (75.6%). In contrast, few (<5%) recalled hearing technical messages to place air conditioners on recirculate, use High-Efficiency Particulate Air filters, or use N-95 respirators during ash cleanup, and less than 10% of all respondents followed these specific recommendations. The authors found that nontechnical message recall, understanding, and compliance were high during the wildfires, and reported recall and compliance with technical messages were much lower. Future disaster health communication should further explore barriers to recall and compliance with technical recommendations. C1 [Sugerman, David E.; Dee, Deborah L.] Ctr Dis Control & Prevent, Off Workplace & Career Dev, Atlanta, GA USA. [Keir, Jane M.; Lipman, Harvey; Waterman, Stephen H.] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA USA. [Ginsberg, Michele] Cty San Diego Hlth & Human Serv Agcy, Community Epidemiol Branch, San Diego, CA USA. RP Sugerman, DE (reprint author), Ctr Dis Control, Global Immunizat Div, 1600 Clifton Rd NE,MS F-62, Atlanta, GA 30333 USA. EM ggi4@cdc.gov NR 22 TC 2 Z9 2 U1 0 U2 6 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1081-0730 J9 J HEALTH COMMUN JI J. Health Commun. PY 2012 VL 17 IS 6 BP 698 EP 712 DI 10.1080/10810730.2011.635777 PG 15 WC Communication; Information Science & Library Science SC Communication; Information Science & Library Science GA 972ZJ UT WOS:000306320100006 PM 22494384 ER PT J AU D'Anna, LH Margolis, AD Warner, L Korosteleva, OA O'Donnell, L Rietmeijer, CA Klausner, JD Nomura, W Malotte, CK AF D'Anna, L. H. Margolis, A. D. Warner, L. Korosteleva, O. A. O'Donnell, L. Rietmeijer, C. A. Klausner, J. D. Nomura, W. Malotte, C. K. CA Safe City Study Grp TI Condom use problems during anal sex among men who have sex with men (MSM): Findings from the Safe in the City Study SO AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV LA English DT Article DE condom use problems; consistent condom use; men who have sex with men; sexual partnerships ID BISEXUAL MEN; DELAYED APPLICATION; UNITED-STATES; YOUNG MEN; GAY MEN; RISK; INFECTION; FAILURE; PREVALENCE; COMMUNITY AB Our research aims were to: (1) assess the prevalence of two condom use problems: breakage or slippage and partial use (delayed application or early removal) among men who have sex with men (MSM) seeking services in urban US STD clinics; and (2) examine the association between these condom use problems and participant, partner and partnership characteristics. Analysis was restricted to HIV-negative MSM who reported having anal sex at least once in the preceding 3 months and who completed both the baseline and 3 month follow-up assessments. Two models were fitted using the generalized estimating equations (GEE) approach. A total of 263 MSM (median age=32 years) reported 990 partnerships. Partnerships with no condom use 422 (42.6%) were excluded. Thus, 207 MSM and 568 partnerships were included. Among condom users, 100% use was reported within 454 partnerships (79.9%) and <100% within 114 (20.1%), and 21(3.7%) reported both condom use problems, 25 (4.4%) reported only breakage, 67 (11.8%) reported only partial use, and 455 (80.1%) reported no errors. The breakage or slippage and partial use rates per condom used were 3.4% and 11.2%, respectively. A significantly higher rate of breakage or slippage occurred among non-main partnerships. Characteristics associated with increased odds for condom breakage or slippage were: lower education level (OR=2.78; CI: 1.1-7.5), non-main partner status (OR=4.1; CI: 1.5-11.7), and drunk or high during sex (OR=2.0; CI: 1.1-3.8), and for partial use: lower education level (OR=2.6; CI: 1.0-6.6), perceived partner sexually transmitted infections (STI) risk (OR=2.4; CI: 1.3-4.2), and inconsistent condom use (OR=3.7; CI: 2.0-6.6). A high percentage of MSM partnerships reported no condom use and among condom users, a sizable proportion did not use them consistently or correctly. MSM may benefit from interventions designed to increase proficiency for condom use with a particular focus on the behaviors of inconsistent and partial condom use. C1 [D'Anna, L. H.; Korosteleva, O. A.; Nomura, W.; Malotte, C. K.] Calif State Univ Long Beach, Ctr Hlth Care Innovat, Long Beach, CA 90840 USA. [Margolis, A. D.; Warner, L.] Ctr Dis Control & Prevent CDC, Div HIV AIDS Prevent, Atlanta, GA USA. [Warner, L.] Ctr Dis Control & Prevent CDC, Div Reprod Hlth, Atlanta, GA USA. [O'Donnell, L.] Denver Publ Hlth, Denver, CO USA. [Rietmeijer, C. A.] Univ San Francisco, San Francisco, CA 94117 USA. [Klausner, J. D.] Univ Calif San Francisco, San Francisco Sch Med, San Francisco, CA 94143 USA. RP D'Anna, LH (reprint author), Calif State Univ Long Beach, Ctr Hlth Care Innovat, Long Beach, CA 90840 USA. EM ldanna@csulb.edu FU NIMHD NIH HHS [P20 MD003942, P20MD003942] NR 23 TC 12 Z9 12 U1 0 U2 6 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0954-0121 J9 AIDS CARE JI Aids Care-Psychol. Socio-Med. Asp. Aids-Hiv PY 2012 VL 24 IS 8 SI SI BP 1028 EP 1038 DI 10.1080/09540121.2012.668285 PG 11 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychology, Multidisciplinary; Respiratory System; Social Sciences, Biomedical SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychology; Respiratory System; Biomedical Social Sciences GA 968JD UT WOS:000305974200012 PM 22519680 ER PT J AU Bachani, AM Tran, NT Sann, S Ballesteros, MF Gnim, C Ou, A Sem, P Nie, XY Hyder, AA AF Bachani, Abdulgafoor M. Tran, Nhan T. Sann, Socheata Ballesteros, Michael F. Gnim, Chandara Ou, Amra Sem, Panhavuth Nie, Xiaoyu Hyder, Adnan A. TI Helmet Use Among Motorcyclists in Cambodia: A Survey of Use, Knowledge, Attitudes, and Practices SO TRAFFIC INJURY PREVENTION LA English DT Article DE Motorcycles; Head injuries; Helmets; Cambodia; Road safety; Asia ID HEAD-INJURIES; PREVALENCE; RIDERS AB Objective: Road traffic injuries (RTIs) are a leading cause of disability and fatality globally. Motorcycle-related injuries, mainly head injuries, and related deaths and disabilities are a significant contributor to the burden of disease in low- and middle-income countries (LMICs). Helmets have been proven to be an effective way to reduce the risk of head injury. As motorcycle use continually increases in Cambodia, head injuries and related deaths and disabilities are expected to rise. This article aims to assess the current status of helmet use in Cambodia, as well as the knowledge, attitudes, and practices among motorcyclists, in order to assist with better planning and implementation of injury prevention strategies. Methods: Two separate methodologies were employed for this study Helmet observations were conducted in Phnom Penh, Kandal, Kampong Speu, Siem Reap, and Kampong Chain to assess the current status of helmet use during the day and at night. Roadside knowledge, attitudes, and practice (KAP) interviews were also conducted in Phnom Penh, Kandal, and Kampong Speu to determine the prevailing beliefs around helmet use in Cambodia. Results: Based on observations, the proportion of helmet wearing across all study sites was 25 percent at night and 43 percent during the day among all motorcyclists. The observed proportion was up to 10 times higher among drivers compared to passengers. The top 3 reasons for always wearing a helmet were lifesaving potential, legal duty and police fines. Almost 60 percent of respondents said that their use or nonuse of a helmet depended on where they were driving. Helmet quality price, style, and color were important factors influencing the decision to purchase a helmet. Conclusions: A paradox appears to exist in Cambodia; though awareness of the benefits of wearing a helmet is high, actual helmet use remains low in the country Daytime usage is higher than nighttime, and these proportions are significantly higher among drivers compared to passengers. There is a continuing need to improve the proportion of all-day helmet wearing, especially at night and among motorcycle passengers in Cambodia. C1 [Bachani, Abdulgafoor M.; Tran, Nhan T.; Nie, Xiaoyu; Hyder, Adnan A.] Johns Hopkins Bloomberg Sch Publ Hlth, Johns Hopkins Int Injury Res Unit, Baltimore, MD 21205 USA. [Sann, Socheata; Gnim, Chandara; Ou, Amra; Sem, Panhavuth] Handicap Int Belgium, Phnom Penh, Cambodia. [Ballesteros, Michael F.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Bachani, AM (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Johns Hopkins Int Injury Res Unit, 615 N Wolfe St,Suite E-8132, Baltimore, MD 21205 USA. EM abachani@jhsph.edu FU Bloomberg Philanthropies FX This work was conducted as part of the Road Safety in 10 Countries project funded by the Bloomberg Philanthropies. Additional support for some of the data collection was provided by the International Union for Health Promotion and Education and the Centers for Disease Control and Prevention. NR 18 TC 14 Z9 14 U1 0 U2 9 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1538-9588 J9 TRAFFIC INJ PREV JI Traffic Inj. Prev. PY 2012 VL 13 SU 1 BP 31 EP 36 DI 10.1080/15389588.2011.630763 PG 6 WC Public, Environmental & Occupational Health; Transportation SC Public, Environmental & Occupational Health; Transportation GA 966UT UT WOS:000305863600007 PM 22414126 ER PT J AU DellaValle, CT Hoppin, JA Hines, CJ Andreotti, G Alavanja, MCR AF DellaValle, Curt T. Hoppin, Jane A. Hines, Cynthia J. Andreotti, Gabriella Alavanja, Michael C. R. TI Risk-Accepting Personality and Personal Protective Equipment Use Within the Agricultural Health Study SO JOURNAL OF AGROMEDICINE LA English DT Article DE Agricultural Health Study; personal protective equipment; pesticide; risk-accepting behavior ID PESTICIDE APPLICATORS; CANCER-RISK; SAFE USE; FARMERS; BEHAVIORS; EXPOSURE; SMALLHOLDERS; FARMWORKERS; CALIFORNIA; KNOWLEDGE AB Pesticide exposures can be reduced by use of personal protective equipment as well as proper mixing and application practices. The authors examined the effects of risk-accepting personality on personal protective equipment (PPE) use and mixing and application practices among private pesticide applicators and their spouses within the Agricultural Health Study (AHS) in Iowa and North Carolina and commercial applicators in Iowa. The AHS follow-up questionnaire included four questions designed to assess attitudes toward risk. Analysis was limited to those who were currently working on a farm or registered as a commercial applicator and indicated current pesticide use (n = 25,166). Respondents who answered three or more questions in the affirmative (private applicators: n = 4160 [21%]; commercial applicators: n = 199 [14%]; spouses: n = 829 [23%]) were classified as having a risk-accepting personality. Logistic regression was used to evaluate specific work practices associated with risk-accepting attitudes. Among private applicators, the likelihood of using any PPE when mixing or loading pesticides was lower among risk-acceptors compared to risk-averse individuals (odds ratio [OR] = 0.72, 95% confidence interval [CI]: 0.65-0.79). A similar relationship was observed among commercial applicators (OR = 0.77, 95% CI: 0.34-1.77) but not among spouses (OR = 1.09, 95% CI: 0.90-1.33). Among private applicators, risk-acceptors were more likely than the risk-averse to apply pesticides within 50 feet of the home (OR = 1.21, 95% CI: 1.01-1.44), compared to further than 1/4 mile. These findings suggest that the decisions to use personal protective equipment and properly handle/apply pesticides may be driven by risk-accepting personality traits. C1 [DellaValle, Curt T.; Andreotti, Gabriella; Alavanja, Michael C. R.] Natl Canc Inst, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Rockville, MD USA. [Hoppin, Jane A.] Natl Inst Environm Hlth Sci, Epidemiol Branch, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC USA. [Hines, Cynthia J.] NIOSH, Cincinnati, OH 45226 USA. RP DellaValle, CT (reprint author), Natl Canc Inst, Div Canc Epidemiol & Genet, Occupat & Environm Epidemiol Branch, NIH DHHS, 6120 Execut Blvd,EPS 8011, Bethesda, MD 20892 USA. EM dellavallec@mail.nih.gov FU National Institutes of Health; National Institute of Environmental Health Sciences [Z01-ES049030]; National Cancer Institute [Z01-CP010119] FX This work was supported by the intramural research program of the National Institutes of Health, the National Institute of Environmental Health Sciences (Z01-ES049030) and National Cancer Institute (Z01-CP010119). NR 25 TC 3 Z9 3 U1 2 U2 13 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1059-924X J9 J AGROMEDICINE JI J. Agromedicine PY 2012 VL 17 IS 3 BP 264 EP 276 DI 10.1080/1059924X.2012.686390 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 965IS UT WOS:000305761700002 PM 22732067 ER PT J AU Calvert, GM Lee, K Roh, S Davis, KG Tak, S AF Calvert, Geoffrey M. Lee, Kyungsuk Roh, Sangchul Davis, Kermit G. Tak, SangWoo TI Promoting and Protecting Worker Health and Safety in the Republic of Korea Agricultural Sector SO JOURNAL OF AGROMEDICINE LA English DT Article DE Agriculture; injury; Korea; musculoskeletal diseases; pesticides; surveillance ID UNITED-STATES; FARMERS; CANCER; POPULATIONS; PREVALENCE; MORTALITY AB With the exception of agriculture, all other Republic of Korea industrial sectors have comprehensive systems in place for workplace surveillance (i.e., disease, injury, and exposure), research, and targeted interventions. However, because few statistics are available on the occupational health and safety conditions in the Republic of Korea agricultural sector, there is little information to guide interventions to prevent hazardous agricultural exposures. The scant information that is currently available suggests that agriculture ranks among the most hazardous industries in the Republic of Korea. Building on information obtained at the International Symposium on Development of Prevention Strategies for Agricultural Health and Safety held in Suwon, Republic of Korea, in 2005, and embellished with examples of surveillance, research, and intervention activities conducted in the United States and elsewhere, this article provides guidance to promote and protect the health of Korean agricultural workers. This information can also guide other countries to reduce agricultural hazards. C1 [Calvert, Geoffrey M.; Roh, Sangchul] NIOSH, Cincinnati, OH 45226 USA. [Lee, Kyungsuk] Rural Dev Adm, Suwon, South Korea. [Roh, Sangchul] Dankook Univ, Coll Med, Dept Occupat & Environm Med, Cheonan, South Korea. [Davis, Kermit G.] Univ Cincinnati, Cincinnati, OH USA. RP Calvert, GM (reprint author), NIOSH, 4676 Columbia Pkwy,R-17, Cincinnati, OH 45226 USA. EM jac6@cdc.gov NR 37 TC 6 Z9 6 U1 4 U2 6 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1059-924X J9 J AGROMEDICINE JI J. Agromedicine PY 2012 VL 17 IS 3 BP 326 EP 337 DI 10.1080/1059924X.2012.686383 PG 12 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 965IS UT WOS:000305761700007 PM 22732072 ER PT J AU Shulman, ST Yogev, R Rodewald, LE Block, SL AF Shulman, Stanford T. Yogev, Ram Rodewald, Lance E. Block, Stan L. TI History and Development of Haemophilus Influenzae Type B Vaccine SO PEDIATRIC ANNALS LA English DT Editorial Material C1 [Rodewald, Lance E.] Ctr Dis Control & Prevent, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. NR 0 TC 1 Z9 1 U1 1 U2 2 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0090-4481 EI 1938-2359 J9 PEDIATR ANN JI Pediatr. Annu. PD JAN PY 2012 VL 41 IS 1 BP 38 EP 39 DI 10.3928/00904481-20111209-11 PG 2 WC Pediatrics SC Pediatrics GA 965CW UT WOS:000305744800011 ER PT J AU Shulman, ST Pickering, LK AF Shulman, Stanford T. Pickering, Larry K. TI A Conversation with Larry K. Pickering, MD, FAAP, FIDSA SO PEDIATRIC ANNALS LA English DT Editorial Material C1 [Pickering, Larry K.] CDC, Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Pickering, Larry K.] Emory Univ, Sch Med, Atlanta, GA 30322 USA. [Shulman, Stanford T.] United Ctr, Chicago, IL USA. RP Shulman, ST (reprint author), United Ctr, Chicago, IL USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0090-4481 EI 1938-2359 J9 PEDIATR ANN JI Pediatr. Annu. PD JAN PY 2012 VL 41 IS 1 BP 40 EP 40 DI 10.3928/00904481-20111209-12 PG 1 WC Pediatrics SC Pediatrics GA 965CW UT WOS:000305744800012 ER PT J AU Seth, P Lang, DLL DiClemente, RJ Braxton, ND Crosby, RA Brown, LK Hadley, W Donenberg, GR AF Seth, Puja Lang, Delia L. DiClemente, Ralph J. Braxton, Nikia D. Crosby, Richard A. Brown, Larry K. Hadley, Wendy Donenberg, Geri R. TI Gender differences in sexual risk behaviours and sexually transmissible infections among adolescents in mental health treatment SO SEXUAL HEALTH LA English DT Article DE risky sexual behaviour ID AMERICAN FEMALE ADOLESCENTS; CONDOM USE; PSYCHIATRIC-DISORDERS; HIV-INFECTION; UNITED-STATES; AGES 14; PREVALENCE; WOMEN; COMMUNICATION; YOUTH AB Background: Adolescents with a history of psychiatric disorder(s) are particularly vulnerable to contracting sexually transmissible infections (STIs) as a result of psychological and emotional states associated with higher rates of risky sexual behaviour. The present study examined gender differences in sexual risk behaviours and STI among adolescents in mental health treatment. Methods: Three hundred and seventy nine sexually active adolescents, aged 13-18 years, from a larger multisite study, who received mental health treatment during the past year, completed an audio computer-assisted self interview assessing sociodemographics, psychiatric symptomatology and HIV/STI risk behaviours, and provided urine specimens tested for STI. Results: After controlling for covariates, multivariate logistic regression models indicated that female adolescents were more likely to have had an HIV test (adjusted odds ratio (AOR) = 3.2, P = 0.0001), obtain their HIV test results (AOR = 2.9, P = 0.03), refuse sex out of fear for STI acquisition (AOR = 1.7, P = 0.04), or avoid a situation that might lead to sex (AOR = 2.4, P = 0.001), and were less likely to have a casual sex partner (AOR = 0.40, P = 0.002). Additionally, females were more likely to report inconsistent condom use (AOR = 2.60, P = 0.001) and have a STI (AOR = 9.1, P = 0.0001) than their male counterparts. Conclusions: Female adolescents receiving mental health treatment were more than nine times as likely to have an STI and more likely to use condoms inconsistently. The standard of care for mental health practice for adolescents should include referrals for STI screening and treatment as well as assessment and discussion of risky sexual behaviours as part of the treatment plan when indicated. Effective programs should address gender-specific communication and behavioural skills. C1 [Seth, Puja; Lang, Delia L.; DiClemente, Ralph J.; Braxton, Nikia D.] Emory Univ, Rollins Sch Publ Hlth, Dept Behav Sci & Hlth Educ, Atlanta, GA 30322 USA. [Seth, Puja; Lang, Delia L.; DiClemente, Ralph J.] Emory Ctr AIDS Res, Social & Behav Sci Core, Atlanta, GA 30322 USA. [Crosby, Richard A.] Univ Kentucky, Coll Publ Hlth, Dept Hlth Behav, Lexington, KY 40379 USA. [Brown, Larry K.; Hadley, Wendy] Rhode Isl Hosp, Bradley Hasbro Childrens Res Ctr, Providence, RI 02903 USA. [Brown, Larry K.; Hadley, Wendy] Brown Univ, Alpert Med Sch, Providence, RI 02903 USA. [Donenberg, Geri R.] Univ Illinois, Dept Psychiat, Chicago, IL 60606 USA. RP Seth, P (reprint author), Ctr Dis Control & Prevent, Div Global HIV AIDS, 1600 Clifton Rd NE,MS E-04, Atlanta, GA 30333 USA. EM pseth@cdc.gov FU NIMH [MH63008]; Lifespan/Tufts/Brown Center for AIDS Research; Center for AIDS Research [P30 AI050409] FX Research was supported by NIMH grant MH63008 to Rhode Island Hospital (P.I. Larry K. Brown, M.D.) and the Lifespan/Tufts/Brown Center for AIDS Research. This work also was supported in part by the Center for AIDS Research (P30 AI050409). Special thanks to the Project Style Study Group (for names and affiliations please see Project Style Group listing). NR 54 TC 3 Z9 3 U1 2 U2 11 PU CSIRO PUBLISHING PI CLAYTON PA UNIPARK, BLDG 1, LEVEL 1, 195 WELLINGTON RD, LOCKED BAG 10, CLAYTON, VIC 3168, AUSTRALIA SN 1448-5028 EI 1449-8987 J9 SEX HEALTH JI Sex Health PY 2012 VL 9 IS 3 BP 240 EP 246 DI 10.1071/SH10098 PG 7 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 958MU UT WOS:000305243300007 PM 22697141 ER PT S AU Albert, DA Ward, A Allweiss, P Graves, DT Knowler, WC Kunzel, C Leibel, RL Novak, KF Oates, TW Papapanou, PN Schmidt, AM Taylor, GW Lamster, IB Lalla, E AF Albert, David A. Ward, Angela Allweiss, Pamela Graves, Dana T. Knowler, William C. Kunzel, Carol Leibel, Rudolph L. Novak, Karen F. Oates, Thomas W. Papapanou, Panos N. Schmidt, Ann Marie Taylor, George W. Lamster, Ira B. Lalla, Evanthia GP Annals NY Acad Sci TI Diabetes and oral disease: implications for health professionals SO ANNALS MEETING REPORTS SE Annals of the New York Academy of Sciences LA English DT Article DE diabetes; oral disease; meeting report; complications; periodontal disease; management; interprofessional care ID QUALITY-OF-LIFE; PERIODONTAL-DISEASE; GLYCEMIC CONTROL; DENTAL OFFICE; PERINATAL OUTCOMES; PREGNANCY OUTCOMES; FOLLOW-UP; BONE LOSS; MELLITUS; PREVENTION AB "Diabetes and Oral Disease: Implications for Health Professionals" was a one-day conference convened by the Columbia University College of Dental Medicine, the Columbia University College of Physicians and Surgeons, and the New York Academy of Sciences on May 4, 2011 in New York City. The program included an examination of the bidirectional relationship between oral disease and diabetes and the interprofessional working relationships for the care of people who have diabetes. The overall goal of the conference was to promote discussion among the healthcare professions who treat people with diabetes, encourage improved communication and collaboration among them, and, ultimately, improve patient management of the oral and overall effects of diabetes. Attracting over 150 members of the medical and dental professions from eight different countries, the conference included speakers from academia and government and was divided into four sessions. This report summarizes the scientific presentations of the event.(a) C1 [Albert, David A.; Ward, Angela; Kunzel, Carol; Papapanou, Panos N.; Lamster, Ira B.; Lalla, Evanthia] Columbia Univ, Coll Dent Med, New York, NY 10032 USA. [Allweiss, Pamela] Ctr Dis Control & Prevent, Atlanta, GA USA. [Allweiss, Pamela] Univ Kentucky, Coll Publ Hlth, Lexington, KY USA. [Graves, Dana T.] Univ Penn, Sch Dent Med, Philadelphia, PA 19104 USA. [Knowler, William C.] NIDDKD, NIH, Phoenix, AZ USA. [Leibel, Rudolph L.] Columbia Univ Coll Phys & Surg, New York, NY 10032 USA. [Novak, Karen F.] Amer Dent Educ Assoc, Washington, DC USA. [Oates, Thomas W.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Schmidt, Ann Marie] NYU, Sch Med, New York, NY USA. [Taylor, George W.] Univ Calif San Francisco, Sch Dent, San Francisco, CA USA. RP Albert, DA (reprint author), Columbia Univ, Coll Dent Med, 630 W 168th St,Box 20, New York, NY 10032 USA. EM daa1@columbia.edu; el94@columbia.edu FU National Institute of Diabetes and Digestive and Kidney Diseases FX Dr. Knowler is supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases. NR 71 TC 6 Z9 7 U1 2 U2 21 PU BLACKWELL SCIENCE PUBL PI OXFORD PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND SN 0077-8923 BN 978-1-57331-886-0 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 2012 VL 1255 BP 1 EP 15 DI 10.1111/j.1749-6632.2011.06460.x PG 15 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA BAV38 UT WOS:000305606100001 PM 22409777 ER PT J AU B'Hymer, C Krieg, E Cheever, KL Toennis, CA Clark, JC Kesner, JS Gibson, R Butler, MA AF B'Hymer, Clayton Krieg, Edward, Jr. Cheever, Kenneth L. Toennis, Christine A. Clark, John C. Kesner, James S. Gibson, Roger Butler, Mary Ann TI EVALUATION AND COMPARISON OF URINARY METABOLIC BIOMARKERS OF EXPOSURE FOR THE JET FUEL JP-8 SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES LA English DT Article ID S-PHENYLMERCAPTURIC ACID; (2-METHOXYETHOXY)ACETIC ACID; MASS-SPECTROMETRY; BIS(2-METHOXYETHYL) ETHER; BENZENE METABOLITES; CREATININE; QUANTIFICATION; VALIDATION; TOXICANT; TOLUENE AB A study of workers exposed to jet fuel propellant 8 (JP-8) was conducted at U. S. Air Force bases and included the evaluation of three biomarkers of exposure: S-benzylmercapturic acid (BMA), S-phenylmercapturic acid (PMA), and (2-methoxyethoxy) acetic acid (MEAA). Postshift urine specimens were collected from various personnel categorized as high (n = 98), moderate (n = 38) and low (n = 61) JP-8 exposure based on work activities. BMA and PMA urinary levels were determined by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), and MEAA urinary levels were determined by gas chromatography-mass spectrometry (GC-MS). The numbers of samples determined as positive for the presence of the BMA biomarker (above the test method's limit of detection [LOD = 0.5 ng/ml]) were 96 (98.0%), 37 (97.4%), and 58 (95.1%) for the high, moderate, and low (control) exposure workgroup categories, respectively. The numbers of samples determined as positive for the presence of the PMA biomarker (LOD = 0.5 ng/ml) were 33 (33.7%), 9 (23.7%), and 12 (19.7%) for the high, moderate, and low exposure categories. The numbers of samples determined as positive for the presence of the MEAA biomarker (LOD = 0.1 mu g/ml) were 92 (93.4%), 13 (34.2%), and 2 (3.3%) for the high, moderate, and low exposure categories. Statistical analysis of the mean levels of the analytes demonstrated MEAA to be the most accurate or appropriate biomarker for JP-8 exposure using urinary concentrations either adjusted or not adjusted for creatinine; mean levels of BMA and PMA were not statistically significant between workgroup categories after adjusting for creatinine. C1 [B'Hymer, Clayton; Krieg, Edward, Jr.; Cheever, Kenneth L.; Toennis, Christine A.; Clark, John C.; Kesner, James S.; Butler, Mary Ann] NIOSH, Ctr Dis Control & Prevent, US Dept Hlth & Human Serv, Div Appl Res & Technol,Taft Lab, Cincinnati, OH 45226 USA. [Gibson, Roger] Uniform Serv Univ, Prevent Med & Biometr Dept, Bethesda, MD USA. RP B'Hymer, C (reprint author), NIOSH, Ctr Dis Control & Prevent, US Dept Hlth & Human Serv, Div Appl Res & Technol,Taft Lab, 4676 Columbia Pkwy, Cincinnati, OH 45226 USA. EM CBHymer@cdc.gov FU Intramural CDC HHS [CC999999] NR 34 TC 0 Z9 0 U1 0 U2 8 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1528-7394 J9 J TOXICOL ENV HEAL A JI J. Toxicol. Env. Health Part A PY 2012 VL 75 IS 11 BP 661 EP 672 DI 10.1080/15287394.2012.688483 PG 12 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 962OY UT WOS:000305555900005 PM 22712851 ER PT J AU Menendez, CC AF Menendez, Cammie Chaumont TI Workplace Violence and Aggression SO WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION LA English DT Editorial Material C1 NIOSH, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. RP Menendez, CC (reprint author), NIOSH, Ctr Dis Control & Prevent, 1095 Willowdale Rd,MS 1811, Morgantown, WV 26505 USA. EM CMenendez@cdc.gov FU Intramural CDC HHS [CC999999] NR 0 TC 0 Z9 0 U1 0 U2 1 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1051-9815 J9 WORK JI Work PY 2012 VL 42 IS 1 BP 3 EP 4 DI 10.3233/WOR-2012-1320 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 960MQ UT WOS:000305393000002 PM 27077154 ER PT J AU Jenkins, EL Fisher, BS Hartley, D AF Jenkins, E. Lynn Fisher, Bonnie S. Hartley, Dan TI Safe and secure at work?: Findings from the 2002 Workplace Risk Supplement SO WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION LA English DT Article DE Violence; workplace risk perception; workplace victimization; Workplace Risk Supplement AB Objective: To examine employee's perception of safety and related workplace safety and prevention issues, including their use of self-protection measures and victimization experience. Participants: The Workplace Risk Supplement (WRS) to the National Crime Victimization Survey (NCVS) was administered to 55,158 employed respondents who were 16 years or older. Methods: Trained U. S. Census Bureau interviewers administered the WRS in all households selected for the NCVS during the 6-month reference period from January through June 2002. Responses from the 55,158 WRS respondents were weighted to obtain national estimates, resulting in 142,410,858 cases. Results: The demographic distribution of WRS respondents is very similar to that of the U. S. labor force. Seven percent of respondents reported that they worried about someone in their workplace attacking them, while nearly 4% experienced victimization. The majority indicated that they felt that their workplace, the neighborhood around their workplace, and places they traveled to as part of their job were either "Very Safe" or "Somewhat Safe" from crime. Six percent carried some type of self protection while at work although this varied by occupation. Conclusions: Employees largely feel safe from violence while working. Differences in victimization by occupation bolster efforts to focus workplace violence prevention in high-risk occupations. C1 [Jenkins, E. Lynn] Ctr Dis Control & Prevent, Etiol & Surveillance Branch, Div Violence Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA. [Fisher, Bonnie S.] Coll Educ Criminal Justice & Human Serv, Sch Criminal Justice, Cincinnati, OH USA. [Hartley, Dan] NIOSH, Anal & Field Evaluat Branch, Div Safety Res, Morgantown, WV USA. RP Jenkins, EL (reprint author), Ctr Dis Control & Prevent, Etiol & Surveillance Branch, Div Violence Prevent, Natl Ctr Injury Prevent & Control, 4770 Buford Highway,M-S F63, Atlanta, GA 30341 USA. EM LJenkins@cdc.gov NR 11 TC 4 Z9 4 U1 0 U2 3 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1051-9815 J9 WORK JI Work PY 2012 VL 42 IS 1 BP 57 EP 66 DI 10.3233/WOR-2012-1329 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 960MQ UT WOS:000305393000010 PM 22635150 ER PT J AU Hartley, D Doman, B Hendricks, SA Jenkins, EL AF Hartley, Dan Doman, Brooke Hendricks, Scott A. Jenkins, E. Lynn TI Non-fatal workplace violence injuries in the United States 2003-2004: A follow back study SO WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION LA English DT Article DE NEISS-work; hospital emergency department; injury surveillance; healthcare workers ID WORKERS AB Objective: Contribute to the prevention of workplace violence by providing information about the nature and circumstances of nonfatal assaults among U. S. workers. Methods: Data were collected from the National Electronic Injury Surveillance System occupational supplement (NEISS-Work), a stratified probability sample of U. S. hospitals. Workplace violence victims identified from NEISS-Work voluntarily completed a followback interview detailing the nature and circumstances surrounding their workplace violence incident. Results: The majority of workplace violence injuries treated in emergency departments resulted from simple assaults that did not involve any lost time from work. Almost two-thirds of these workplace violence victims filed only an internal report. Eighty percent of the victims returned to their same jobs and will not change the way they do their jobs as a result of the violent incident. Conclusions: Nonfatal workplace violence is an important risk for U. S. workers, particularly in some occupations and industries. Prevention strategies need to be tailored by occupation and work environment. Results from the healthcare section of this survey indicate high numbers of incidents during times when the healthcare workers were assisting patients with medical and non-medical needs. C1 [Hartley, Dan; Doman, Brooke; Hendricks, Scott A.] NIOSH, Anal & Field Evaluat Branch, Div Safety Res, Morgantown, WV 26505 USA. [Jenkins, E. Lynn] Ctr Dis Control & Prevent, Etiol & Surveillance Branch, Div Violence Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA. RP Hartley, D (reprint author), NIOSH, Anal & Field Evaluat Branch, Div Safety Res, 1095 Willowdale Rd,M-S 1811, Morgantown, WV 26505 USA. EM DHartley@cdc.gov NR 18 TC 7 Z9 7 U1 0 U2 4 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1051-9815 J9 WORK JI Work PY 2012 VL 42 IS 1 BP 125 EP 135 DI 10.3233/WOR-2012-1328 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 960MQ UT WOS:000305393000016 PM 22635156 ER PT J AU Diwakar, PK Kulkarni, P AF Diwakar, Prasoon K. Kulkarni, Pramod TI Measurement of elemental concentration of aerosols using spark emission spectroscopy SO JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY LA English DT Article ID INDUCED BREAKDOWN SPECTROSCOPY; INDUCED PLASMA; SPECTROCHEMICAL ANALYSIS; DISCHARGE; METALS; TIME; DIAGNOSTICS; EXCITATION; ONLINE; FIELD AB A coaxial microelectrode system has been used to collect and analyse the elemental composition of aerosol particles in near real-time using spark emission spectroscopy. The technique involves focused electrostatic deposition of charged aerosol particles onto the flat tip of a microelectrode, followed by introduction of spark discharge. A pulsed spark discharge was generated across the electrodes with input energy ranging from 50 to 300 mJ per pulse, resulting in the formation of controlled pulsed plasma. The particulate matter on the cathode tip is ablated and atomized by the spark plasma, resulting in atomic emissions which are subsequently recorded using a broadband optical spectrometer for element identification and quantification. The plasma characteristics were found to be very consistent and reproducible even after several thousands of spark discharges using the same electrode system. The spark plasma was characterized by measuring the excitation temperature (similar to 7000 to 10 000 K), electron density (similar to 1016 cm(-3)), and evolution of spectral responses as a function of time. The system was calibrated using particles containing Pb, Si, Na and Cr. Absolute mass detection limits in the range 11 pg to 1.75 ng were obtained. Repeatability of spectral measurements varied from 2 to 15%. The technique offers key advantages over similar microplasma-based techniques such as laser-induced breakdown spectroscopy, as: (i) it does not require any laser beam optics and eliminates any need for beam alignment, (ii) pulse energy from dc power supply in SIBS system can be much higher compared to that from laser source of the same physical size, and (iii) it is quite conducive to compact, field-portable instrumentation. C1 [Diwakar, Prasoon K.; Kulkarni, Pramod] NIOSH, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. RP Kulkarni, P (reprint author), NIOSH, Ctr Dis Control & Prevent, 4676 Columbia Pkwy,MS R7, Cincinnati, OH 45226 USA. EM Pskulkarni@cdc.gov RI Diwakar, Prasoon/E-8689-2010 FU Intramural CDC HHS [CC999999] NR 48 TC 6 Z9 7 U1 3 U2 31 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 0267-9477 J9 J ANAL ATOM SPECTROM JI J. Anal. At. Spectrom. PY 2012 VL 27 IS 7 BP 1101 EP 1109 DI 10.1039/c2ja30025g PG 9 WC Chemistry, Analytical; Spectroscopy SC Chemistry; Spectroscopy GA 958QX UT WOS:000305256600007 PM 26491209 ER PT J AU Diwakar, PK Loper, KH Matiaske, AM Hahn, DW AF Diwakar, Prasoon K. Loper, Kristofer H. Matiaske, Anna-Maria Hahn, David. W. TI Laser-induced breakdown spectroscopy for analysis of micro and nanoparticles SO JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY LA English DT Article ID AEROSOL-PARTICLES; PLASMA-SPECTROSCOPY; METAL AEROSOLS; ONLINE; LIBS AB The use of laser-induced breakdown spectroscopy (LIBS) for analysis of micro-and nanoparticles is explored, including a brief review of the recent research, both fundamentals and applications, along with new experimental work regarding aerosol particle sampling statistics, analysis of laser ablation particles via aerosol LIBS for matrix effect minimization for bulk solids analysis, and a novel aerosol particle concentration scheme that is suited for near real-time analysis of aerosol nanoparticles. The statistical analysis reveals that the LIBS particle sampling physics are well modeled using Poisson sampling statistics, as based on analysis of calcium-rich ambient air particles. The laser-ablation LIBS (LA-LIBS) methodology was explored for a range of disparate metallic and non-metallic bulk samples, revealing a linear calibration curve for all six samples over the range of relative Mn/Fe mass concentrations. Finally, the microneedle concentration technique for aerosol nanoparticle analysis was successfully demonstrated with linear mass calibration curves for copper-rich nanoparticles. Overall, a fundamental understanding of the plasma-particle physics has enabled the formulation of robust LIBS-based nanoparticle schemes. C1 [Loper, Kristofer H.; Hahn, David. W.] Univ Florida, Gainesville, FL 32611 USA. [Diwakar, Prasoon K.] NIOSH, Cincinnati, OH 45213 USA. [Matiaske, Anna-Maria] BAM Fed Inst Mat Res & Testing, Berlin, Germany. RP Hahn, DW (reprint author), Univ Florida, Gainesville, FL 32611 USA. EM dwhahn@ufl.edu RI Diwakar, Prasoon/E-8689-2010 FU National Science Foundation, as part of the Plasma-Analyte Interaction Working Group [CHE-0822469]; NSF; DFG FX The work was funded in part by the National Science Foundation through grant CHE-0822469, as part of the Plasma-Analyte Interaction Working Group, a collaborative effort of the University of Florida, Federal Institute of Materials Research and Testing (BAM) in Berlin, and the Institute for Analytical Sciences (ISAS) in Dortmund, jointly funded by the NSF and DFG. The microneedle aerosol sampling study was conducted at NIOSH, Cincinnati. PKD would like to thank Pramod Kulkarni (NIOSH) for his help, support and guidance. NR 31 TC 23 Z9 24 U1 3 U2 51 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 0267-9477 J9 J ANAL ATOM SPECTROM JI J. Anal. At. Spectrom. PY 2012 VL 27 IS 7 BP 1110 EP 1119 DI 10.1039/c2ja30012e PG 10 WC Chemistry, Analytical; Spectroscopy SC Chemistry; Spectroscopy GA 958QX UT WOS:000305256600008 ER PT J AU Alemnji, GA Branch, S Best, A Kalou, M Parekh, B Waruiru, W Milstrey, E Conn, W Nkengasong, JN Lecher, S AF Alemnji, George A. Branch, Songee Best, Anton Kalou, Mireille Parekh, Bharat Waruiru, Wanjiru Milstrey, Eric Conn, William Nkengasong, John N. Lecher, Shirley TI Strengthening national laboratory health systems in the Caribbean region SO GLOBAL PUBLIC HEALTH LA English DT Article DE HIV/AIDS; Caribbean region; laboratory health systems strengthening President's Emergency Plan for AIDS Relief (PEPFAR) II AB The President's Emergency Plan for AIDS Relief (PEPFAR) programme for the Caribbean Region was established in 2008 to address health system challenges, including fragile laboratory services and systems. The laboratory component of this programme consisted of several phases: assessment of laboratory needs of all 12 countries engaged in the programme; addressing gaps identified during the assessment; and monitoring and evaluation of the progress achieved. After one year of PEPFAR collaboration with national governments and other partners, laboratory services and systems greatly improved. Some of the milestones include: (1) the accreditation of a public laboratory; (2) improved access to HIV diagnosis with faster turnaround time; (3) establishment of capacity for platforms for DNA PCR, viral load and HIV drug resistance; (4) development of the laboratory workforce; and (5) establishment of a framework for implementation of sustainable quality management systems for laboratory accreditation. The progress recorded in strengthening laboratory health systems after one year of initiating this collaboration shows that with a rigorous initial assessment, programme design and intervention and strategic partnership, national laboratory health systems can be greatly enhanced to support programme implementation. Continued collaboration and country leadership is critical to create an integrated and sustainable laboratory network in the Caribbean. C1 [Alemnji, George A.; Waruiru, Wanjiru; Lecher, Shirley] Ctr Dis Control & Prevent, Div Global HIV AIDS, Caribbean Reg Off, Bridgetown, Barbados. [Branch, Songee] Ladymeade Gardens, Ladymeade Reference Unit, St Michael, Barbados. [Best, Anton] Minist Hlth, HIV AIDS Program, St Michael, Barbados. [Kalou, Mireille; Parekh, Bharat; Nkengasong, John N.] Ctr Dis Control & Prevent, Int Lab Branch, Div Global HIV AIDS, Atlanta, GA USA. [Conn, William] PEPFAR Caribbean Reg Off, Bridgetown, Barbados. [Milstrey, Eric] US So Command, Dept Def, Miami, FL USA. RP Alemnji, GA (reprint author), Ctr Dis Control & Prevent, Div Global HIV AIDS, Caribbean Reg Off, Bridgetown, Barbados. EM ikv3@cdc.gov NR 24 TC 5 Z9 5 U1 0 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1744-1692 J9 GLOB PUBLIC HEALTH JI Glob. Public Health PY 2012 VL 7 IS 6 BP 648 EP 660 DI 10.1080/17441692.2012.670861 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 952PQ UT WOS:000304805000007 PM 22519703 ER PT J AU Ubeda, C Espitia-Hardeman, V Bhalla, K Borse, NN Abraham, JP Dellinger, A Ferrante, D Peltzer, R AF Ubeda, Clotilde Espitia-Hardeman, Victoria Bhalla, Kavi Borse, Nagesh N. Abraham, Jerry Puthenpurakal Dellinger, Ann Ferrante, Daniel Peltzer, Raquel TI National burden of road traffic injuries in Argentina SO INTERNATIONAL JOURNAL OF INJURY CONTROL AND SAFETY PROMOTION LA English DT Article DE road traffic injuries; burden of disease; Argentina; middle-income countries; RTI mortality AB More than 1.2 million people die and as many as 50 million people are injured or disabled due to road traffic injuries (RTIs) every year worldwide. The lack of reliable data hinders efforts to describe the characteristics of the issue and prioritise prevention activities. The objective was to provide a snapshot of fatal and non-fatal RTI in Argentina. We used the methodology proposed by the Global Burden of Disease Injury Expert group. External causes of deaths with unknown codes were proportionately redistributed over the known categories. In 2007 in Argentina, we estimated 5915 RTI deaths, compared with 3983 RTI deaths reported previously by the Ministry of Health, accounting for 1931 additional cases. The highest number of deaths occurred in young men (15-29 years old), although the highest RTI death rates were in the age group of 55 years and older. Four-wheeled vehicle occupants were the most common road user type killed (59.1%); vulnerable road users represented one third (29.5%) of deaths and 64% of non-fatal RTI. The national and regional estimates of RTI in Argentina should help policy makers and public-health researchers to understand the importance of RTI prevention and design specific interventions to further reduce these preventable deaths and injuries. C1 [Ubeda, Clotilde] Inst Nacl Epidemiol Dr JH Jara INE, Adm Nacl Labs & Inst Salud ANLIS Malbran, Mar Del Plata, Buenos Aires, Argentina. [Espitia-Hardeman, Victoria] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Div Violence Prevent, Atlanta, GA USA. [Bhalla, Kavi; Abraham, Jerry Puthenpurakal] Harvard Univ, Sch Publ Hlth, Dept Global Hlth & Populat, Cambridge, MA 02138 USA. [Borse, Nagesh N.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. [Borse, Nagesh N.; Dellinger, Ann] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Div Unintent Injury Prevent, Atlanta, GA USA. [Peltzer, Raquel] Univ Nacl Mar del Plata, Grp Promoc Salud, Mar Del Plata, Buenos Aires, Argentina. RP Ubeda, C (reprint author), Inst Nacl Epidemiol Dr JH Jara INE, Adm Nacl Labs & Inst Salud ANLIS Malbran, Mar Del Plata, Buenos Aires, Argentina. EM clotildeubeda@yahoo.com.ar NR 26 TC 3 Z9 3 U1 1 U2 9 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1745-7300 J9 INT J INJ CONTROL SA JI Int. J. Inj. Control Saf. Promot. PY 2012 VL 19 IS 1 BP 9 EP 18 DI 10.1080/17457300.2011.581377 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 948CT UT WOS:000304481900003 PM 21660797 ER PT J AU Lin, CY Waller, LA Lyles, RH AF Lin, Carol Y. Waller, Lance A. Lyles, Robert H. TI The likelihood approach for the comparison of medical diagnostic system with multiple binary tests SO JOURNAL OF APPLIED STATISTICS LA English DT Article DE combining tests; test performance; decision theory; false-positive rate; likelihood; sensitivity; biomarkers ID CORRELATED LOCAL DECISIONS; SENSOR DETECTION SYSTEMS; BENIGN PELVIC MASSES; OPTIMAL DATA FUSION; DISTRIBUTED DETECTION; BLADDER-CANCER; MULTINORMAL INTEGRATION; SERUM MARKERS; CLASSIFICATION; COMBINATIONS AB Detection (diagnosis) techniques play an important role in clinical medicine. Early detection of diseases could be life-saving, and the consequences of false-positives and false-negatives could be costly. Using multiple measurements strategy is a popular tool to increase diagnostic accuracy. In addition to the new diagnostic technology, recent advances in genomics, proteomics, and other areas have allowed some of these newly developed individual biomarkers measured by non-invasive and inexpensive procedures (e. g. samples from serum, urine or stool) to progress from basic discovery research to assay development. As more tests become commercially available, there is an increasing interest for clinicians to request combinations of various non-invasive and inexpensive tests to increase diagnostic accuracy. Using information regarding individual test sensitivities and specificities, we proposed a likelihood approach to combine individual test results and to approximate or estimate the combined sensitivities and specificities of various tests taking into account the conditional correlations to quantify system performance. To illustrate this approach, we considered an example using various combinations of diagnostic tests to detect bladder cancer. C1 [Lin, Carol Y.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Waller, Lance A.; Lyles, Robert H.] Emory Univ, Dept Biostat & Bioinformat, Atlanta, GA 30322 USA. RP Lin, CY (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM clin@cdc.gov FU National Institute of Environmental Health Sciences [R01-ES007750] FX The authors would like to thank two anonymous referees for their constructive comments and suggestions. The second author was partially supported by National Institute of Environmental Health Sciences R01-ES007750 grant. The method proposed and opinions expressed here are those of the authors and do not necessary represent the official position of the Centers for Disease Control and Prevention. NR 41 TC 0 Z9 0 U1 0 U2 3 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0266-4763 EI 1360-0532 J9 J APPL STAT JI J. Appl. Stat. PY 2012 VL 39 IS 7 BP 1437 EP 1454 DI 10.1080/02664763.2011.650688 PG 18 WC Statistics & Probability SC Mathematics GA 948DW UT WOS:000304484800005 ER PT J AU Lozier, MJ Curwin, B Nishioka, MG Sanderson, W AF Lozier, Matthew J. Curwin, Brian Nishioka, Marcia G. Sanderson, Wayne TI Determinants of Atrazine Contamination in the Homes of Commercial Pesticide Applicators Across Time SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE atrazine; commercial applicator; herbicide; Iowa; pesticide; take-home exposure ID NON-HODGKINS-LYMPHOMA; HERBICIDE ATRAZINE; SURFACE-WATER; EXPOSURE; CHILDREN; FARM; CALIFORNIA; HOUSEHOLDS; DEFECTS; WORKERS AB Twenty-nine commercial pesticide applicator households in eastern Iowa were enrolled to investigate in-home contamination of atrazine, the most commonly used corn herbicide in the Unites States. From each home, four vacuum dust samples were collected during atrazine application season (Visit 1) and again 6 months later during winter months (Visit 2). Samples were taken from the following locations: primary entryway for pesticide applicator, living room, master bedroom, and kitchen. The applicator completed an atrazine handling log and household questionnaire with spouse. Of the 230 dust samples, only 2 were below the level of detection, 2 ng of atrazine per gram (ng/g) of fine dust (dust particle size 5-150 mu m). Dust levels were standardized to chemical loading. During application season the entryway (2.68 ng/cm(2)) and kitchen (0.47 ng/cm(2)) had the highest geometric mean atrazine chemical loading. The entryway chemical loading during Visit 2 was the second highest aggregate (0.55 ng/cm(2)). Aggregate concentrations were significantly higher at Visit 1 compared with Visit 2 when paired by location (p <= 0.02). Analysis showed that job (application, mixing/loading, or both) was not associated with in-home atrazine contamination. Linear regression showed a strong positive association between atrazine handling (number of acres applied with atrazine, number of days atrazine handled, and pounds of atrazine handled) and aggregate dust chemical loading from both visits (p = 0.06, 0.03, and 0.10, respectively). Frequency of vacuuming was inversely associated with Visit 2 concentrations (p = 0.10) and showed a weaker association with Visit 1 (p = 0.30). Removing shoes outside the home was associated with lower atrazine chemical loading (p = 0.03), and applicators changing work clothes in the master bedroom had significantly increased atrazine chemical loading in master bedrooms (p = 0.01). Changes in hygiene practices for commercial pesticide applicators could significantly reduce atrazine and, likely, other pesticide contaminations in the home. C1 [Lozier, Matthew J.] Univ Iowa, Coll Publ Hlth, Dept Occupat & Environm Hlth, Iowa City, IA 52242 USA. [Curwin, Brian] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH USA. [Nishioka, Marcia G.] Battelle Mem Inst, Columbus, OH 43201 USA. [Sanderson, Wayne] Univ Kentucky, Dept Epidemiol, Lexington, KY USA. RP Lozier, MJ (reprint author), Univ Iowa, Coll Publ Hlth, Dept Occupat & Environm Hlth, UI Res Pk,102 IREH, Iowa City, IA 52242 USA. EM matthew-lozier@uiowa.edu FU Heartland Center for Occupational Health and Safety at the University of Iowa; Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health [T42OH008491] FX We are grateful to Dr. Charles Lynch and the Agricultural Health Study for their initial help in recruiting participants. We would like to thank Donna Vosburgh and Kevin L. Dunn for assisting in carrying out field surveys. This research was supported by a pilot project research training grant from the Heartland Center for Occupational Health and Safety at the University of Iowa. The Heartland Center, an Education and Research Center, is supported by Training Grant No. T42OH008491 from the Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health. NR 29 TC 6 Z9 6 U1 1 U2 13 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1545-9624 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2012 VL 9 IS 5 BP 289 EP 297 DI 10.1080/15459624.2012.668658 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 949RX UT WOS:000304594700003 PM 22506545 ER PT J AU Methner, M Crawford, C Geraci, C AF Methner, M. Crawford, C. Geraci, C. TI Evaluation of the Potential Airborne Release of Carbon Nanofibers During the Preparation, Grinding, and Cutting of Epoxy-Based Nanocomposite Material SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE carbon nanofiber; composite; cutting; exposure; grinding; nanomaterials; release; sanding ID REACTOR CLEANOUT OPERATIONS; ASSESSMENT TECHNIQUE NEAT; EXHAUST VENTILATION LEV; INHALATION EXPOSURE; ENGINEERED NANOMATERIALS; NANOTUBES; IDENTIFICATION; COMPOSITES; PARTICLES; RESPONSES AB The National Institute for Occupational Safety and Health conducted an initial, task-based comparative assessment to determine the potential for release of carbon nanofibers (CNFs) during dry material handling, wet cutting, grinding, and sanding (by machine and hand) of plastic composite material containing CNFs. Using a combination of direct-reading instruments and filter-based air sampling methods for airborne mass and transmission electron microscopy (TEM), concentrations were measured and characterized near sources of particle generation, in the breathing zone of the workers, and in the general work area. Tasks such as surface grinding of composite material and manually transferring dry CNFs produced substantial increases in particle number concentration (range = 20,000-490,000 1-cm(-3)). Concomitant increases in mass concentration were also associated with most tasks. Nearly 90% of all samples examined via TEM indicated that releases of CNFs do occur and that the potential for exposure exists. These findings also indicate that improperly designed, maintained, or installed engineering controls may not be completely effective in controlling releases. Unprotected skin exposure to CNFs was noted in two instances and indicated the need for educating workers on the need for personal protective equipment. C1 [Methner, M.; Crawford, C.; Geraci, C.] NIOSH, Cincinnati, OH 45226 USA. RP Methner, M (reprint author), NIOSH, 4676 Columbia Pkwy,R-11, Cincinnati, OH 45226 USA. EM MMethner@cdc.gov NR 30 TC 23 Z9 23 U1 1 U2 21 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2012 VL 9 IS 5 BP 308 EP 318 DI 10.1080/15459624.2012.670790 PG 11 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 949RX UT WOS:000304594700005 PM 22545869 ER PT S AU Fowler, MG Kourtis, AP Aizire, J Onyango-Makumbi, C Bulterys, M AF Fowler, Mary Glenn Kourtis, Athena P. Aizire, Jim Onyango-Makumbi, Carolyne Bulterys, Marc BE Kourtis, AP Bulterys, M TI Breastfeeding and Transmission of HIV-1: Epidemiology and Global Magnitude SO HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) AND BREASTFEEDING: SCIENCE, RESEARCH ADVANCES, AND POLICY SE Advances in Experimental Medicine and Biology LA English DT Article; Book Chapter ID MOTHER-TO-CHILD; HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; VITAMIN-A SUPPLEMENTATION; SHORT-COURSE ZIDOVUDINE; PREVENTION TRIALS 012; CELL-ASSOCIATED HIV-1; RNA VIRAL LOAD; DAR-ES-SALAAM; POSTNATAL TRANSMISSION C1 [Fowler, Mary Glenn] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA. [Fowler, Mary Glenn] Johns Hopkins Univ, Res Collaborat, Onsite Makerere Univ, Kampala, Uganda. [Kourtis, Athena P.] Ctr Dis Control & Prevent, Div Reprod Hlth, NCCDPHP, Atlanta, GA 30341 USA. [Aizire, Jim] Johns Hopkins Univ, Res Collaborat, Makerere Univ, Kampala, Uganda. [Bulterys, Marc] Ctr Dis Control & Prevent CDC, Div Global HIV AIDS DGHA, Ctr Global Hlth, Atlanta, GA 30333 USA. [Bulterys, Marc] CDC Global AIDS Program, Beijing, Peoples R China. [Bulterys, Marc] UCLA Sch Publ Hlth, Los Angeles, CA USA. RP Fowler, MG (reprint author), Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA. EM mgfowler@mujhu.org NR 109 TC 8 Z9 8 U1 0 U2 3 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0065-2598 BN 978-1-4614-2250-1 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2012 VL 743 BP 3 EP 25 DI 10.1007/978-1-4614-2251-8_1 D2 10.1007/978-1-4614-2251-8 PG 23 WC Biology; Medicine, Research & Experimental SC Life Sciences & Biomedicine - Other Topics; Research & Experimental Medicine GA BAG88 UT WOS:000304124900001 PM 22454338 ER PT S AU Ou, CY Fiscus, S Ellenberger, D Parekh, B Korhonen, C Nkengasong, J Bulterys, M AF Ou, Chin-Yih Fiscus, Susan Ellenberger, Dennis Parekh, Bharat Korhonen, Christine Nkengasong, John Bulterys, Marc BE Kourtis, AP Bulterys, M TI Early Diagnosis of HIV Infection in the Breastfed Infant SO HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) AND BREASTFEEDING: SCIENCE, RESEARCH ADVANCES, AND POLICY SE Advances in Experimental Medicine and Biology LA English DT Article; Book Chapter ID HUMAN-IMMUNODEFICIENCY-VIRUS; POLYMERASE CHAIN-REACTION; TO-CHILD TRANSMISSION; DRIED BLOOD SPOTS; P24 ANTIGEN-ASSAY; RESOURCE-LIMITED SETTINGS; REAL-TIME PCR; TYPE-1 INFECTION; UNITED-STATES; WHOLE-BLOOD C1 [Ou, Chin-Yih; Korhonen, Christine; Bulterys, Marc] Ctr Dis Control & Prevent CDC, Div Global HIV AIDS DGHA, Ctr Global Hlth, Atlanta, GA 30333 USA. [Ou, Chin-Yih; Korhonen, Christine; Bulterys, Marc] CDC Global AIDS Program, Beijing, Peoples R China. [Ou, Chin-Yih; Korhonen, Christine; Bulterys, Marc] UCLA Sch Publ Hlth, Los Angeles, CA USA. [Fiscus, Susan] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA. [Ellenberger, Dennis; Parekh, Bharat; Nkengasong, John] US Ctr Dis Control & Prevent, Global AIDS Program, Atlanta, GA USA. RP Ou, CY (reprint author), Ctr Dis Control & Prevent CDC, Div Global HIV AIDS DGHA, Ctr Global Hlth, 1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM cho2@cdc.gov NR 126 TC 2 Z9 2 U1 0 U2 3 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0065-2598 BN 978-1-4614-2250-1 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2012 VL 743 BP 51 EP 65 DI 10.1007/978-1-4614-2251-8_4 D2 10.1007/978-1-4614-2251-8 PG 15 WC Biology; Medicine, Research & Experimental SC Life Sciences & Biomedicine - Other Topics; Research & Experimental Medicine GA BAG88 UT WOS:000304124900004 PM 22454341 ER PT S AU Belec, L Kourtis, AP AF Belec, Laurent Kourtis, Athena P. BE Kourtis, AP Bulterys, M TI B Lymphocyte-Derived Humoral Immune Defenses in Breast Milk Transmission of the HIV-1 SO HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) AND BREASTFEEDING: SCIENCE, RESEARCH ADVANCES, AND POLICY SE Advances in Experimental Medicine and Biology LA English DT Article; Book Chapter ID HUMAN-IMMUNODEFICIENCY-VIRUS; MOTHER-TO-CHILD; LEUKOCYTE PROTEASE INHIBITOR; CELL-MEDIATED CYTOTOXICITY; LACTATING RHESUS-MONKEYS; AFRICAN-GREEN MONKEYS; NATURAL ANTIBODIES; DENDRITIC CELLS; POSTNATAL TRANSMISSION; HIV-1-INFECTED WOMEN C1 [Belec, Laurent] Univ Paris 05, Sorbonne Paris Cite Paris 5, F-75908 Paris 15, France. [Belec, Laurent] Hop Europeen Georges Pompidou, Virol Lab, F-75908 Paris 15, France. [Kourtis, Athena P.] Ctr Dis Control & Prevent, Div Reprod Hlth, NCCDPHP, Atlanta, GA 30341 USA. RP Belec, L (reprint author), Univ Paris 05, Sorbonne Paris Cite Paris 5, 15-20 Rue Leblanc, F-75908 Paris 15, France. EM laurent.belec@egp.aphp.fr NR 187 TC 5 Z9 5 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0065-2598 BN 978-1-4614-2250-1 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2012 VL 743 BP 139 EP 160 DI 10.1007/978-1-4614-2251-8_10 D2 10.1007/978-1-4614-2251-8 PG 22 WC Biology; Medicine, Research & Experimental SC Life Sciences & Biomedicine - Other Topics; Research & Experimental Medicine GA BAG88 UT WOS:000304124900010 PM 22454347 ER PT S AU Sabbaj, S Ibegbu, CC Kourtis, AP AF Sabbaj, Steffanie Ibegbu, Chris C. Kourtis, Athena P. BE Kourtis, AP Bulterys, M TI Cellular Immunity in Breast Milk: Implications for Postnatal Transmission of HIV-1 to the Infant SO HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) AND BREASTFEEDING: SCIENCE, RESEARCH ADVANCES, AND POLICY SE Advances in Experimental Medicine and Biology LA English DT Article; Book Chapter ID IMMUNODEFICIENCY-VIRUS TYPE-1; CD8(+) T-CELLS; LACTATING RHESUS-MONKEYS; MAMMARY EPITHELIAL-CELLS; CHEMOKINE RECEPTOR 9; EXPRESS HIGH-LEVELS; HUMAN COLOSTRUM; GASTROINTESTINAL-TRACT; IMMUNOLOGICAL ASPECTS; HIV-1-INFECTED WOMEN C1 [Sabbaj, Steffanie] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA. [Ibegbu, Chris C.] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA USA. [Kourtis, Athena P.] Ctr Dis Control & Prevent, Div Reprod Hlth, NCCDPHP, Atlanta, GA 30341 USA. RP Sabbaj, S (reprint author), Univ Alabama Birmingham, Dept Med, 908 20th St S,CCB 334, Birmingham, AL 35294 USA. EM sabbaj@uab.cdu OI Sabbaj, Steffanie/0000-0003-4052-6819 NR 86 TC 4 Z9 4 U1 0 U2 3 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0065-2598 BN 978-1-4614-2250-1 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2012 VL 743 BP 161 EP 169 DI 10.1007/978-1-4614-2251-8_11 D2 10.1007/978-1-4614-2251-8 PG 9 WC Biology; Medicine, Research & Experimental SC Life Sciences & Biomedicine - Other Topics; Research & Experimental Medicine GA BAG88 UT WOS:000304124900011 PM 22454348 ER PT S AU Kourtis, AP de Vincenzi, I Jamieson, DJ Bulterys, M AF Kourtis, Athena P. de Vincenzi, Isabelle Jamieson, Denise J. Bulterys, Marc BE Kourtis, AP Bulterys, M TI Antiretroviral Drugs During Breastfeeding for the Prevention of Postnatal Transmission of HIV-1 SO HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) AND BREASTFEEDING: SCIENCE, RESEARCH ADVANCES, AND POLICY SE Advances in Experimental Medicine and Biology LA English DT Article; Book Chapter ID TO-CHILD TRANSMISSION; EXTENDED-DOSE NEVIRAPINE; DAR-ES-SALAAM; RANDOMIZED-TRIAL; HIV-1-INFECTED WOMEN; ORAL ZIDOVUDINE; COTE-DIVOIRE; MILK; PROPHYLAXIS; PREGNANCY C1 [Kourtis, Athena P.; Jamieson, Denise J.] Ctr Dis Control & Prevent, Div Reprod Hlth, NCCDPHP, Atlanta, GA 30341 USA. [de Vincenzi, Isabelle] WHO, CH-1211 Geneva, Switzerland. [Bulterys, Marc] Ctr Dis Control & Prevent CDC, Div Global HIV AIDS DGHA, Ctr Global Hlth, Atlanta, GA 30333 USA. [Bulterys, Marc] CDC Global AIDS Program, Beijing, Peoples R China. [Bulterys, Marc] UCLA Sch Publ Hlth, Los Angeles, CA USA. RP Kourtis, AP (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, NCCDPHP, 4770 Buford Highway NE,MSK34, Atlanta, GA 30341 USA. EM apk3@cdc.gov; apk3@cdc.gov NR 45 TC 3 Z9 3 U1 0 U2 4 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0065-2598 BN 978-1-4614-2250-1 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2012 VL 743 BP 173 EP 183 DI 10.1007/978-1-4614-2251-8_12 D2 10.1007/978-1-4614-2251-8 PG 11 WC Biology; Medicine, Research & Experimental SC Life Sciences & Biomedicine - Other Topics; Research & Experimental Medicine GA BAG88 UT WOS:000304124900012 PM 22454349 ER PT S AU Korhonen, C Wang, LM Wang, LH Fuller, S Wang, F Bulterys, M AF Korhonen, Christine Wang, Liming Wang, Linhong Fuller, Serena Wang, Fang Bulterys, Marc BE Kourtis, AP Bulterys, M TI Breastfeeding and HIV Infection in China SO HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) AND BREASTFEEDING: SCIENCE, RESEARCH ADVANCES, AND POLICY SE Advances in Experimental Medicine and Biology LA English DT Article; Book Chapter ID SEXUALLY-TRANSMITTED-DISEASES; FREE ANTIRETROVIRAL TREATMENT; TO-CHILD TRANSMISSION; RAPID SCALE-UP; SICHUAN PROVINCE; COMMERCIAL SEX; HEPATITIS-B; DRUG-USERS; INFANTS; RISK C1 [Korhonen, Christine; Fuller, Serena; Bulterys, Marc] Ctr Dis Control & Prevent CDC, Div Global HIV AIDS DGHA, Ctr Global Hlth, Atlanta, GA 30333 USA. [Korhonen, Christine; Fuller, Serena; Bulterys, Marc] CDC Global AIDS Program, Beijing, Peoples R China. [Korhonen, Christine; Fuller, Serena; Bulterys, Marc] UCLA Sch Publ Hlth, Los Angeles, CA USA. [Wang, Fang] China Ctr Dis Control & Prevent, Natl Ctr Women & Childrens Hlth, Beijing, Peoples R China. RP Bulterys, M (reprint author), Ctr Dis Control & Prevent CDC, Div Global HIV AIDS DGHA, Ctr Global Hlth, 1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM zbe2@cdc.gov NR 76 TC 3 Z9 3 U1 0 U2 1 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0065-2598 BN 978-1-4614-2250-1 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2012 VL 743 BP 237 EP 245 DI 10.1007/978-1-4614-2251-8_17 D2 10.1007/978-1-4614-2251-8 PG 9 WC Biology; Medicine, Research & Experimental SC Life Sciences & Biomedicine - Other Topics; Research & Experimental Medicine GA BAG88 UT WOS:000304124900017 PM 22454354 ER PT S AU Adler, MR Brewinski, M Heap, AN Bolu, O AF Adler, Michelle R. Brewinski, Margaret Heap, Arnie N. Bolu, Omotayo BE Kourtis, AP Bulterys, M TI The Role of the President's Emergency Plan for AIDS Relief in Infant and Young Child Feeding Guideline Development and Program Implementation SO HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) AND BREASTFEEDING: SCIENCE, RESEARCH ADVANCES, AND POLICY SE Advances in Experimental Medicine and Biology LA English DT Article; Book Chapter ID HIV-FREE SURVIVAL; POSTNATAL TRANSMISSION; DOSE NEVIRAPINE; MOTHER; BOTSWANA; PROPHYLAXIS; PREVENTION; ZIDOVUDINE; PREGNANCY; MORTALITY C1 [Adler, Michelle R.; Bolu, Omotayo] Ctr Dis Control & Prevent, Div Global HIV AIDS, Maternal & Child Hlth Branch, Prevent Mother Child HIV Transmiss PMTCT, Atlanta, GA 30333 USA. [Brewinski, Margaret; Heap, Arnie N.] US Agcy Int Dev, Off HIV AIDS, Washington, DC 20523 USA. RP Adler, MR (reprint author), Ctr Dis Control & Prevent, Div Global HIV AIDS, Maternal & Child Hlth Branch, Prevent Mother Child HIV Transmiss PMTCT, 1600 Clifton Rd NE,Mail Stop E-04, Atlanta, GA 30333 USA. EM madler@cdc.gov NR 48 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0065-2598 BN 978-1-4614-2250-1 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2012 VL 743 BP 247 EP 260 DI 10.1007/978-1-4614-2251-8_18 D2 10.1007/978-1-4614-2251-8 PG 14 WC Biology; Medicine, Research & Experimental SC Life Sciences & Biomedicine - Other Topics; Research & Experimental Medicine GA BAG88 UT WOS:000304124900018 PM 22454355 ER PT S AU Little, KM Hu, DJ Dominguez, KL AF Little, Kristen M. Hu, Dale J. Dominguez, Ken L. BE Kourtis, AP Bulterys, M TI HIV-1 and Breastfeeding in the United States SO HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) AND BREASTFEEDING: SCIENCE, RESEARCH ADVANCES, AND POLICY SE Advances in Experimental Medicine and Biology LA English DT Article; Book Chapter ID IMMUNODEFICIENCY-VIRUS TYPE-1; MOTHER-TO-CHILD; ACTIVE ANTIRETROVIRAL THERAPY; POSTNATAL TRANSMISSION; MITOCHONDRIAL DYSFUNCTION; NEVIRAPINE RESISTANCE; PREGNANT-WOMEN; INFECTED WOMEN; HEALTH-CARE; HUMAN-MILK C1 [Dominguez, Ken L.] Ctr Dis Control & Prevent, DHAP, NCHHSTP, Atlanta, GA 30333 USA. [Hu, Dale J.] Ctr Dis Control & Prevent, DVH, Natl Ctr HIV AIDS, Sexually Transmitted Dis & TB Prevent NCHHSTP, Atlanta, GA 30333 USA. [Little, Kristen M.] Rollins Sch Publ Hlth, Atlanta, GA USA. RP Dominguez, KL (reprint author), Ctr Dis Control & Prevent, DHAP, NCHHSTP, MS E-45,1600 Clifton Rd, Atlanta, GA 30333 USA. EM KLD0@cdc.gov NR 67 TC 1 Z9 1 U1 0 U2 6 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0065-2598 BN 978-1-4614-2250-1 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2012 VL 743 BP 261 EP 270 DI 10.1007/978-1-4614-2251-8_19 D2 10.1007/978-1-4614-2251-8 PG 10 WC Biology; Medicine, Research & Experimental SC Life Sciences & Biomedicine - Other Topics; Research & Experimental Medicine GA BAG88 UT WOS:000304124900019 PM 22454356 ER PT S AU Bulterys, M Kourtis, AP AF Bulterys, Marc Kourtis, Athena P. BE Kourtis, AP Bulterys, M TI The Future of Breastfeeding in the Face of HIV-1 Infection: Science and Policy SO HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) AND BREASTFEEDING: SCIENCE, RESEARCH ADVANCES, AND POLICY SE Advances in Experimental Medicine and Biology LA English DT Article; Book Chapter ID IMMUNODEFICIENCY-VIRUS TYPE-1; POSTNATAL TRANSMISSION; INFANT; MOTHER; DISEASES; AIDS C1 [Bulterys, Marc] Ctr Dis Control & Prevent CDC, Div Global HIV AIDS DGHA, Ctr Global Hlth, Atlanta, GA 30333 USA. [Bulterys, Marc] CDC Global AIDS Program, Beijing, Peoples R China. [Bulterys, Marc] UCLA Sch Publ Hlth, Los Angeles, CA USA. [Kourtis, Athena P.] Ctr Dis Control & Prevent, Div Reprod Hlth, NCCDPHP, Atlanta, GA 30341 USA. RP Bulterys, M (reprint author), Ctr Dis Control & Prevent CDC, Div Global HIV AIDS DGHA, Ctr Global Hlth, 1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM zbe2@cdc.gov; zbe2@cdc.gov NR 20 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0065-2598 BN 978-1-4614-2250-1 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2012 VL 743 BP 301 EP 304 DI 10.1007/978-1-4614-2251-8_22 D2 10.1007/978-1-4614-2251-8 PG 4 WC Biology; Medicine, Research & Experimental SC Life Sciences & Biomedicine - Other Topics; Research & Experimental Medicine GA BAG88 UT WOS:000304124900022 PM 22454359 ER PT J AU St De Lore, J Thiede, H Cheadle, A Goldbaum, G Carey, JW Hutcheson, RE Jenkins, RA Golden, MR AF St De Lore, Jef Thiede, Hanne Cheadle, Allen Goldbaum, Gary Carey, James W. Hutcheson, Rebecca E. Jenkins, Richard A. Golden, Matthew R. TI HIV Disclosure and Subsequent Sexual Behaviors Among Men Who Have Sex with Men Who Meet Online SO JOURNAL OF HOMOSEXUALITY LA English DT Article DE men who have sex with men; Internet; HIV disclosure ID RISK BEHAVIOR; BISEXUAL MEN; INTERNET USE; LOS-ANGELES; GAY MEN; PROCESSES MODEL; PARTNERS; PREVENTION; REDUCTION; INTERVENTIONS AB To assess HIV disclosure discussions and related sexual behaviors among men who have sex with men (MSM) who meet sex partners online, 28 qualitative interviews with Seattle-area MSM were analyzed using grounded theory methods and themes and behavior patterns were identified. MSM found a greater ease in communicating and could prescreen partners through the Internet. However, no consistent relationship was found between HIV disclosure and subsequent behaviors: some were safer based on disclosure while perceived HIV status led others to risky behaviors. Interventions need to promote accurate disclosure while acknowledging its limitations and the need for men to self-protect. C1 [St De Lore, Jef; Cheadle, Allen] Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA. [Thiede, Hanne; Golden, Matthew R.] Publ Hlth Seattle & King Cty, HIV AIDS Epidemiol Program, Seattle, WA USA. [Goldbaum, Gary] Snohomish Hlth Dist, Everett, WA USA. [Goldbaum, Gary] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. [Carey, James W.; Jenkins, Richard A.] Ctr Dis Control & Prevent, Prevent Res Branch, Div HIV AIDS Prevent, Atlanta, GA USA. [Hutcheson, Rebecca E.] Publ Hlth Seattle & King Cty, Community Hlth Serv, Seattle, WA USA. [Golden, Matthew R.] Univ Washington, Ctr AIDS & STD Allergy & Infect Dis, Seattle, WA 98195 USA. RP St De Lore, J (reprint author), 400 Boylston Ave E 205, Seattle, WA 98102 USA. EM saintdelore@gmail.com NR 44 TC 2 Z9 3 U1 2 U2 5 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0091-8369 J9 J HOMOSEXUAL JI J. Homosex. PY 2012 VL 59 IS 4 BP 592 EP 609 DI 10.1080/00918369.2012.665704 PG 18 WC Psychology, Multidisciplinary; Social Sciences, Interdisciplinary SC Psychology; Social Sciences - Other Topics GA 948XK UT WOS:000304536700005 PM 22500995 ER PT J AU Fagan, JL Beer, L Garland, P Valverde, E Courogen, M Hillman, D Brady, K Bertolli, J AF Fagan, Jennifer L. Beer, Linda Garland, Pamela Valverde, Eduardo Courogen, Maria Hillman, Daniel Brady, Kathleen Bertolli, Jeanne CA Never Care Project TI The influence of perceptions of HIV infection, care, and identity on care entry SO AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV LA English DT Article DE HIV infection; health care accessibility; self-concept; qualitative research; Centers for Disease Control and Prevention ID MEDICAL-CARE; UNITED-STATES; ANTIRETROVIRAL THERAPY; RECEIVING CARE; ACCESS; BARRIERS; TRANSMISSION; VIRUS; SELF AB The benefits of accessing HIV care after diagnosis (e. g., improved clinical outcomes and reduced transmission) are well established. However, many persons who are aware that they are HIV infected have never received HIV medical care. During 2008-2010, we conducted 43 in-depth interviews in three health department jurisdictions among adults who had received an HIV diagnosis but who had never accessed HIV medical care. Respondents were selected from the HIV/AIDS Reporting System, a population-based surveillance system. We explored how respondents perceived HIV infection and HIV medical care. Most respondents associated HIV with death. Many respondents said that HIV medical care was not necessary until one is sick. Further, we explored how these perceptions may have conflicted with one's identity and thus served as barriers to timely care entry. Most respondents perceived themselves as healthy. All respondents acknowledged their HIV serostatus, but many did not self-identify as HIV-positive. Several respondents expressed that they were not ready to receive HIV care immediately but felt that they would eventually attempt to access care. Some stated that they needed time to accept their HIV diagnosis before entering care. To improve timely linkage to care, we suggest that during the posttest counseling session and subsequent linkage-to-care activities, counselors and service providers discuss patient perceptions of HIV, particularly to address beliefs that HIV infection is a "death sentence" or that HIV care is necessary only for those who exhibit symptoms. C1 [Fagan, Jennifer L.; Beer, Linda; Valverde, Eduardo; Bertolli, Jeanne] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. [Garland, Pamela] P3S Corp, San Antonio, TX USA. [Courogen, Maria] Washington State Dept Hlth, Washington, DC USA. [Hillman, Daniel] Indiana State Dept Hlth, Indianapolis, IN 46202 USA. [Brady, Kathleen] Philadelphia Dept Publ Hlth, Philadelphia, PA USA. RP Fagan, JL (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. EM jfagan@cdc.gov NR 29 TC 8 Z9 8 U1 1 U2 5 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0954-0121 J9 AIDS CARE JI Aids Care-Psychol. Socio-Med. Asp. Aids-Hiv PY 2012 VL 24 IS 6 BP 737 EP 743 DI 10.1080/09540121.2011.630360 PG 7 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychology, Multidisciplinary; Respiratory System; Social Sciences, Biomedical SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychology; Respiratory System; Biomedical Social Sciences GA 944LS UT WOS:000304204400009 PM 22148942 ER PT J AU de Ravello, L Tulloch, S Taylor, M AF de Ravello, Lori Tulloch, Scott Taylor, Melanie TI WE WILL BE KNOWN FOREVER BY THE TRACKS WE LEAVE: RISING UP TO MEET THE REPRODUCTIVE HEALTH NEEDS OF AMERICAN INDIAN/ALASKA NATIVE YOUTH SO AMERICAN INDIAN AND ALASKA NATIVE MENTAL HEALTH RESEARCH LA English DT Editorial Material ID SEXUAL RISK; PREGNANCY; HIV/AIDS; INDIANS C1 [de Ravello, Lori] Ctr Dis Control & Prevent, Div Reprod Hlth, Indian Hlth Serv, Natl STD Program, Atlanta, GA 30333 USA. [Tulloch, Scott; Taylor, Melanie] Ctr Dis Control & Prevent, Div STD Prevent, Indian Hlth Serv, Natl STD Program, Atlanta, GA 30333 USA. RP de Ravello, L (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Indian Hlth Serv, Natl STD Program, Atlanta, GA 30333 USA. EM leb8@cdc.gov; sdt2@cdc.gov; smdt7@cdc.gov FU Intramural CDC HHS [CC999999] NR 22 TC 3 Z9 3 U1 1 U2 4 PU UNIV PRESS COLORADO PI NIWOT PA PO BOX 849, NIWOT, CO 80544 USA SN 0893-5394 J9 AM INDIAN ALASKA NAT JI Am. Indian Alsk. Nativ. Ment. Health Res. PY 2012 VL 19 IS 1 SI SI BP I EP X PG 10 WC Psychology, Clinical SC Psychology GA 942PB UT WOS:000304056500001 PM 22569731 ER PT J AU Gajalakshmi, V Kanimozhi, CV Sinha, DN Rahman, K Warren, CW Asma, S AF Gajalakshmi, V. Kanimozhi, C. V. Sinha, D. N. Rahman, K. Warren, C. W. Asma, S. TI Global School Personnel Survey Among 5200 School Personnel in India: Comparison of the Results for the Years 2009 and 2006 SO ASIAN PACIFIC JOURNAL OF CANCER PREVENTION LA English DT Article DE India; tobacco; teachers; school; bidi; cigarette; smokeless; prevalence ID MORTALITY; SMOKING; ADULTS AB Background: The results of the Global School Personnel Survey (GSPS) conducted in India in 2009 are compared with 2006 GSPS to assess any change in 2009 on tobacco use and knowledge and attitudes to tobacco use, training and availability of tobacco control teaching material in schools and the existence of school tobacco control policies. Methods: GSPS is a cross sectional survey conducted twice (2006 and 2009) in entire India. A total of 180 schools were surveyed each time. Results: Of the participating school personnel, 2660 in 2006 and 2575 in 2009, about 95% were teachers and the balance administrators. In 2009, compared to 2006 the prevalence of current smoking of cigarettes (19.6% in 2006 and 10.3% in 2009) and bidis (21.5% in 2006 and 13.9% in 2009) was found to be significantly lower; the percentage of teachers receiving training on preventing youth tobacco use has significantly reduced (16.7% in 2006 and 10.1% in 2009); access of teachers to educational materials on tobacco use and how to prevent its use among youth had not increased (34.6% in 2006 and 37.8% in 2009); there was no change in policy prohibiting tobacco use among students and school personnel; however, ever use of any tobacco on school premises was significantly lower (15.6% in 2006 and 9.6% in 2009). Conclusions: The prevalence of current smoking (cigarettes/bidis) among school personnel and use of any tobacco on school premises were significantly decreased in 2009 as compared to 2006. Necessary action should be planned to increase the number of teachers trained and the availability of teaching materials on preventing youth tobacco use in order to have effective prevention of tobacco use among students. C1 [Gajalakshmi, V.; Kanimozhi, C. V.] Epidemiol Res Ctr, Madras, Tamil Nadu, India. [Gajalakshmi, V.] IRH Inst Res Populat Hlth, Madras, Tamil Nadu, India. [Sinha, D. N.; Rahman, K.] WHO, Reg Off SE Asia, Tobacco Free Initiat, New Delhi, India. [Warren, C. W.; Asma, S.] Ctr Dis Control & Prevent, Off Smoking & Hlth, Atlanta, GA USA. RP Gajalakshmi, V (reprint author), Epidemiol Res Ctr, Madras, Tamil Nadu, India. EM gajaerc@gmail.com FU Tobacco Free Initiative, World Health Organization, SEARO, New Delhi FX This study was funded by the Tobacco Free Initiative, World Health Organization, SEARO, New Delhi and technical assistance was provided by the Office on Smoking and Health, Centers for Disease Control and Prevention, Atlanta, USA. We wish to thank Directors of schools in India and Headmasters and Headmistresses of the selected schools in the survey for giving permission to do this survey and school personnel for their cooperation. VG organized and co-ordinated the survey conducted in 2009 and wrote the initial draft. CVK and DNS contributed to the writing. KR, CWW and SA involved in developing the survey methodology and giving technical assistance. All authors read and approved the final manuscript. NR 9 TC 3 Z9 3 U1 0 U2 2 PU ASIAN PACIFIC ORGANIZATION CANCER PREVENTION PI GYEONGGI-DO PA APJCP HEAD OFFICE, KOREAN NATL CANCER CENTER, 323 ILAN -RO, ILSANDONG-GU, GOYANG-SI, GYEONGGI-DO, 410-769, SOUTH KOREA SN 1513-7368 J9 ASIAN PAC J CANCER P JI Asian Pac. J. Cancer Prev. PY 2012 VL 13 IS 2 BP 539 EP 543 DI 10.7314/APJCP.2012.13.1.539 PG 5 WC Oncology SC Oncology GA 942WK UT WOS:000304081800023 PM 22524821 ER PT J AU Kulshreshtha, A Anderson, LM Goyal, A Keenan, NL AF Kulshreshtha, Ambar Anderson, Laurie M. Goyal, Abhinav Keenan, Nora L. TI Stroke in South Asia: A Systematic Review of Epidemiologic Literature from 1980 to 2010 SO NEUROEPIDEMIOLOGY LA English DT Review DE Stroke; Stroke incidence; Stroke prevalence; Risk factors; South Asia ID CORONARY-HEART-DISEASE; RISK-FACTORS; ISCHEMIC-STROKE; CASE-FATALITY; CARDIOVASCULAR-DISEASE; URBAN-POPULATION; INDIA; PREVALENCE; BURDEN; EXPERIENCE AB Background: Globally 15 million people have an acute stroke every year and one third of them die secondary to stroke events. Most research on stroke prevention and treatment is done in developed countries, yet more than 85% of strokes occur in developing countries. In particular, stroke remains an underrecognized cause of death and disability in South Asia. Methods: We conducted a systematic review to identify reliable and comparable epidemiological evidence on stroke in South Asia from 1980 to 2010. Publications were screened for eligibility to identify only population-based stroke studies. Results: Of the 71 studies retrieved, only 6 studies from South Asia gave us acceptable estimates of the burden of stroke. Population-based studies from South Asia have stroke prevalence in the range of 45-471 per 100,000. The age-adjusted incidence rate varied from approximately 145 per 100,000 to 262 per 100,000. Rural parts of South Asia have a lower stroke prevalence compared with urban areas. Conclusions: Our review highlights the paucity of research data in South Asia. This must be addressed in order to accurately determine the burden of stroke in South Asia, so that specific policy recommendations can be formulated to combat the stroke epidemic in this region. Copyright (C) 2012 S. Karger AG, Basel C1 [Kulshreshtha, Ambar; Goyal, Abhinav] Emory Univ, Dept Epidemiol, Atlanta, GA 30322 USA. [Kulshreshtha, Ambar; Goyal, Abhinav] Emory Univ, Dept Med, Atlanta, GA 30322 USA. [Keenan, Nora L.] CDC, Div Heart Dis & Stroke Prevent, Atlanta, GA 30333 USA. [Anderson, Laurie M.] Washington State Inst Publ Policy, Olympia, WA USA. RP Kulshreshtha, A (reprint author), Emory Univ, Dept Epidemiol, 1518 Clifton Rd NE,2040L CNR, Atlanta, GA 30322 USA. EM akulshr@emory.edu RI Goyal, Abhinav/J-5086-2012 OI Goyal, Abhinav/0000-0002-6286-2349 NR 46 TC 9 Z9 9 U1 0 U2 6 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0251-5350 J9 NEUROEPIDEMIOLOGY JI Neuroepidemiology PY 2012 VL 38 IS 3 BP 123 EP 129 DI 10.1159/000336230 PG 7 WC Public, Environmental & Occupational Health; Clinical Neurology SC Public, Environmental & Occupational Health; Neurosciences & Neurology GA 941TP UT WOS:000303989000001 PM 22433930 ER PT J AU Watanabe, E Zehnbauer, BA Buchman, TG Hirasawa, H Oda, S AF Watanabe, E. Zehnbauer, B. A. Buchman, T. G. Hirasawa, H. Oda, S. TI TUMOR NECROSIS FACTOR-308 POLYMORPHISM IS ASSOCIATED WITH MORTALITY AND VENTILATOR DURATION IN 1057 CAUCASIAN PATIENTS SO SHOCK LA English DT Meeting Abstract CT 7th Congress of the International-Federation-of-Shock-Societies/35th Annual Conference on Shock CY JUN 09-13, 2012 CL Miami Beach, FL SP Int Federat Shock Soc C1 [Watanabe, E.; Hirasawa, H.; Oda, S.] Chiba Univ, Grad Sch Med, Chiba, Japan. [Watanabe, E.; Zehnbauer, B. A.; Buchman, T. G.] Washington Univ, St Louis, MO USA. [Buchman, T. G.] Emory Ctr Crit Care, Atlanta, GA USA. [Zehnbauer, B. A.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PY 2012 VL 37 SU 1 BP 105 EP 105 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 946VL UT WOS:000304385500283 ER PT J AU Nguyen, HT Fry, AM Gubareva, LV AF Nguyen, Ha T. Fry, Alicia M. Gubareva, Larisa V. TI Neuraminidase inhibitor resistance in influenza viruses and laboratory testing methods SO ANTIVIRAL THERAPY LA English DT Review ID PANDEMIC H1N1 2009; OSELTAMIVIR-RESISTANT; A H1N1; A(H1N1) VIRUSES; B VIRUSES; DRUG-RESISTANCE; UNITED-STATES; ACTIVE-SITE; IN-VITRO; ZANAMIVIR RESISTANCE AB Infection with influenza viruses, including seasonal, avian and pandemic viruses, remains a worldwide public health problem. Although influenza virus infection is both vaccine preventable and drug treatable, high rates of mutation and reassortment of viruses can result in reduced effectiveness of vaccines or drugs. Currently, two classes of drugs, adamantanes (M2 blockers) and neuraminidase (NA) inhibitors (NAIs), are available for treatment and chemoprophylaxis of influenza infections. Given these limited antiviral therapy options, resistance to anti-influenza drugs is a constant concern. The emergence and global spread of adamantane-resistant H3N2 viruses in 2003-2004 and oseltamivir-resistant seasonal H1N1 viruses in 2007-2009 demonstrated the ability of drug-resistant variants to rapidly become predominant worldwide. Since the 2009 H1N1 pandemic, all influenza viruses circulating in humans are M2-blocker-resistant and, in general, NAI-susceptible. However, pandemic H1N1 viruses with resistance to the NAI oseltamivir have been reported. 'Permissive' drift mutations and reassortment of viral gene segments have been proposed as mechanisms underlying the retained replicative fitness of resistant viruses. Nevertheless, the precise role of these genetic changes in the efficient transmission and maintenance of resistant viruses in the absence of drug pressure remains poorly understood. In this review, we summarize NAI resistance in influenza viruses and discuss recent challenges in laboratory testing methods. Close monitoring of antiviral resistance among all influenza viruses, both locally and globally, are essential to inform public health strategies for the control of influenza infections. C1 [Nguyen, Ha T.; Fry, Alicia M.; Gubareva, Larisa V.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA. [Nguyen, Ha T.] Atlanta Res & Educ Fdn, Atlanta, GA USA. RP Gubareva, LV (reprint author), Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA. EM LGubareva@cdc.gov NR 133 TC 78 Z9 87 U1 4 U2 27 PU INT MEDICAL PRESS LTD PI LONDON PA 2-4 IDOL LANE, LONDON EC3R 5DD, ENGLAND SN 1359-6535 J9 ANTIVIR THER JI Antivir. Ther. PY 2012 VL 17 IS 1 BP 159 EP 173 DI 10.3851/IMP2067 PN B PG 15 WC Infectious Diseases; Pharmacology & Pharmacy; Virology SC Infectious Diseases; Pharmacology & Pharmacy; Virology GA 937IY UT WOS:000303653400004 PM 22311680 ER PT J AU Yang, JW French, S Holt, J Zhang, XY AF Yang, Jiawen French, Steven Holt, James Zhang, Xingyou TI Measuring the Structure of U.S. Metropolitan Areas, 1970-2000 Spatial Statistical Metrics and an Application to Commuting Behavior SO JOURNAL OF THE AMERICAN PLANNING ASSOCIATION LA English DT Article DE polycentricity; density; urban transportation; spatial decentralization; commuting ID FRANCISCO BAY AREA; SAN-FRANCISCO; EMPLOYMENT CENTERS; LOS-ANGELES; CITY; SUBCENTERS; EVOLUTION; CHICAGO; TRAVEL AB Problem, research strategy, and findings: Metropolitan planning organizations attempt to shape urban form at the regional and metropolitan scale, including the pattern of suburban centers. How do these efforts change behavior? Our study informs that question by way of a new family of urban form metrics summarizing the polycentric structure of U. S. metropolitan areas. Using a spatial statistical approach, these measures are sensitive to the size, amount, and location of suburban centers. The article then tests the influence of these structures on commute times nationally from 1970 to 2000. Takeaway for practice: The influence of development densities on travel in sprawling regions is more complicated than previously understood or measured. While the level of both neighborhood density and regional density explain average commuting times, density also works relatively. The spatial variation of density, the density of suburban centers relative to the region, and the spatial distribution of high-density nodes each appear to play distinct roles in influencing travel. C1 [Yang, Jiawen] Georgia Inst Technol, Sch City & Reg Planning, Atlanta, GA 30332 USA. [French, Steven] Georgia Inst Technol, Coll Architecture, Atlanta, GA 30332 USA. [Holt, James; Zhang, Xingyou] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Atlanta, GA USA. RP Yang, JW (reprint author), Georgia Inst Technol, Sch City & Reg Planning, Atlanta, GA 30332 USA. EM jy78@mail.gatech.edu; steve.french@coa.gatech.edu; jgh4@cdc.gov; gyx8@cdc.gov NR 35 TC 9 Z9 9 U1 3 U2 25 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0194-4363 J9 J AM PLANN ASSOC JI J. Am. Plan. Assoc. PY 2012 VL 78 IS 2 BP 197 EP 209 DI 10.1080/01944363.2012.677382 PG 13 WC Planning & Development; Urban Studies SC Public Administration; Urban Studies GA 936TS UT WOS:000303613500005 ER PT J AU Alzahrani, AG Al Shaiban, HM Al Mazroa, MA Al-Hayani, O MacNeil, A Rollin, PE Memish, ZA AF Alzahrani, Abdullah G. Al Shaiban, Hassan M. Al Mazroa, Mohammad A. Al-Hayani, Osama MacNeil, Adam Rollin, Pierre E. Memish, Ziad A. TI Alkhurma Virus, Subtype of Kyasanur Forest Disease Virus, was Described for the First Time in 1995 in Saudi Arabia - Response to Dr. Madani's Letter SO INTERVIROLOGY LA English DT Letter ID HEMORRHAGIC-FEVER; HUMANS; NAJRAN; TICKS C1 [Memish, Ziad A.] Minist Hlth, Dept Prevent Med, Riyadh 11176, Saudi Arabia. [MacNeil, Adam; Rollin, Pierre E.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Memish, ZA (reprint author), Minist Hlth, Dept Prevent Med, Tower 3,3rd Floor, Riyadh 11176, Saudi Arabia. EM zmemish@yahoo.com NR 8 TC 0 Z9 0 U1 1 U2 4 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0300-5526 J9 INTERVIROLOGY JI Intervirology PY 2012 VL 55 IS 4 BP 261 EP 262 DI 10.1159/000337239 PG 2 WC Virology SC Virology GA 933XL UT WOS:000303399700003 ER PT J AU Adetona, O Sjodin, A Zheng, L Romanoff, LC Aguilar-Villalobos, M Needham, LL Hall, DB Luis, A Cassidy, BE Simpson, CD Naeher, LP AF Adetona, Olorunfemi Sjodin, Andreas Zheng, Li Romanoff, Lovisa C. Aguilar-Villalobos, Manuel Needham, Larry L. Hall, Daniel B. Luis, Antonio Cassidy, Brandon E. Simpson, Christopher D. Naeher, Luke P. TI Personal Exposure to PM2.5 and Urinary Hydroxy-PAH Levels in Bus Drivers Exposed to Traffic Exhaust, in Trujillo, Peru SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE air pollution; bus; CO; minivan; PAH; PM2.5; traffic ID POLYCYCLIC AROMATIC-HYDROCARBONS; PARTICULATE AIR-POLLUTION; PUBLIC TRANSPORTATION MODES; OCCUPATIONAL-EXPOSURE; BIOLOGICAL INDICATOR; COMMUTERS EXPOSURE; DIESEL EXHAUST; 1-HYDROXYPYRENE; MATTER; URBAN AB Public transport vehicle drivers, especially in highly polluted or trafficked areas, are exposed to high levels of air pollutants. In this study, we assessed the influence of traffic on levels of hydroxy polycyclic aromatic hydrocarbons (OH-PAHs) in commercial bus drivers in Trujillo, Peru, by measuring the within-shift changes in the urinary whole weight and creatinine-corrected concentrations of the PAH metabolites. We measured personal PM2.5 as a proxy of exposure to traffic emission. Urine samples were collected daily from two bus drivers and three minivan drivers in Trujillo, pre-, mid-, post-work shift and on days when the drivers were off work (total n = 144). Ten OH-PAH metabolites were measured in the urine samples. Drivers were also monitored for exposure to PM2.5 (n = 41). Daily work shift (mean = 13.1 +/- 1.3 hr) integrated PM2.5 was measured in the breathing zones of the drivers for an average of 10.5 days per driver. The differences across shift in OH-PAH concentrations were not statistically significant except for urinary 2-hydroxyfluorene (2-FLU) (p = 0.04) and 4-hydroxyphenanthrene (4-PHE) (p = 0.01) and creatinine-corrected 4-hydroxyphenanthrene (p = 0.01). Correlation between pairs of hydroxy-PAHs (rho = 0.50 to 0.93) were highest for mid-shift samples. Concentrations of PM2.5 (geometric mean = 64 mu g/m(3); 95% confidence limits = 52 mu g/m(3), 78 mu g/m(3)) is similar to those measured inmany other studies of traffic exposure. There was significant change across work shift for concentrations of only two of the OH-PAHs (2-FLU and 4-PHE). Results indicate that the drivers may have had limited time for clearance of PAH exposure from the body between work shifts. Comparisons of the concentrations of creatinine-corrected hydroxy-PAH to those reported in other studies indicate that exposure of public transport drivers to PAH could be similar. By following the subjects over multiple days, this study gives an indication of appropriate exposure situations for the use of hydroxy-PAHs and will be beneficial in designing future occupational studies of PAH exposure. C1 [Sjodin, Andreas; Zheng, Li; Romanoff, Lovisa C.; Needham, Larry L.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. [Aguilar-Villalobos, Manuel] Asociac Aire Ambiental, Lima, Peru. [Hall, Daniel B.] Univ Georgia, Franklin Coll Arts & Sci, Dept Stat, Athens, GA 30602 USA. [Luis, Antonio] Temple Univ Hosp & Med Sch, Philadelphia, PA 19140 USA. [Simpson, Christopher D.] Univ Washington, Seattle, WA 98195 USA. [Simpson, Christopher D.] Dept Occupat & Environm Hlth Sci, Seattle, WA USA. [Adetona, Olorunfemi; Cassidy, Brandon E.; Naeher, Luke P.] Univ Georgia, Coll Publ Hlth, Dept Environm Hlth Sci, Athens, GA 30602 USA. RP Naeher, LP (reprint author), Univ Georgia, EHS Dept, EHS Bldg, Athens, GA 30602 USA. EM LNaeher@uga.edu RI Sjodin, Andreas/F-2464-2010; Adetona, Olorunfemi/A-2434-2016 NR 61 TC 8 Z9 8 U1 4 U2 39 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2012 VL 9 IS 4 BP 217 EP 229 DI 10.1080/15459624.2012.666142 PG 13 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 936BP UT WOS:000303566200007 PM 22455670 ER PT J AU Laney, AS Petsonk, EL Hale, JM Wolfe, AL Attfield, MD AF Laney, A. Scott Petsonk, Edward L. Hale, Janet M. Wolfe, Anita L. Attfield, Michael D. TI Potential Determinants of Coal Workers' Pneumoconiosis, Advanced Pneumoconiosis, and Progressive Massive Fibrosis Among Underground Coal Miners in the United States, 2005-2009 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID VIRGINIA; HEALTH AB Objectives. We better defined the distribution and determinants of coal workers' pneumoconiosis (CWP) among US underground coal miners. Methods. We obtained chest radiographs from the mobile unit of an enhanced surveillance program begun in 2005 by the National Institute for Occupational Safety and Health for underground coal miners. B Readers classified them for presence of pneumoconiosis. Results. Miners from 15 states participated (n = 6658). The prevalence of CWP was higher in 3 states (Kentucky, 9.0%; Virginia, 8.0%; West Virginia, 4.8%) than in 12 other states (age-adjusted risk ratio [RR] = 4.5; 95% confidence interval [CI] = 3.3, 6.1). Miners in these 3 states were younger and had less mining tenure, but advanced CWP (category >= 2/1; RR = 8.1; 95% CI = 3.9, 16.9) and progressive massive fibrosis (RR = 10.5; 95% CI = 3.8, 29.1) was more prevalent among them. Advanced CWP and progressive massive fibrosis were more prevalent among workers at mines with fewer than 155 miners, irrespective of mining region, than among workers at larger mines. Conclusions. Enhanced surveillance results confirmed the persistence of severe CWP among US coal miners and documented the health consequences of inadequate dust control for miners in parts of Appalachia and at smaller mines. (Am J Public Health. 2012;102:S279-S283. doi:10.2105/AJPH.2011.300427) C1 [Laney, A. Scott; Petsonk, Edward L.; Hale, Janet M.; Wolfe, Anita L.; Attfield, Michael D.] NIOSH, Surveillance Branch, Div Resp Dis Studies, Ctr Dis Control & Prevent, Morgantown, WV USA. RP Laney, AS (reprint author), 1095 Willowdale Rd,Mail Stop HG900-2, Morgantown, WV 26505 USA. EM alaney@cdc.gov RI Banks, Tamara/G-3007-2012 NR 18 TC 12 Z9 13 U1 0 U2 19 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PY 2012 VL 102 SU 2 BP S279 EP S283 DI 10.2105/AJPH.2011.300427 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 928FV UT WOS:000302969500023 PM 22401526 ER PT J AU VanHandel, M Beltrami, JF MacGowan, RJ Borkowf, CB Margolis, AD AF VanHandel, Michelle Beltrami, John F. MacGowan, Robin J. Borkowf, Craig B. Margolis, Andrew D. TI Newly Identified HIV Infections in Correctional Facilities, United States, 2007 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; COST-EFFECTIVENESS; JAIL; INMATES; ROUTINE; SYSTEM; PRISON AB We used Centers for Disease Control and Prevention HIV Counseling and Testing System data from 2007 to determine the percentage and characteristics of persons newly identified as HIV-positive in US correctional facilities. The newly identified HIV positivity was 0.7%, and 30% of detainees newly identified with HIV were categorized as having low-risk heterosexual contact or no acknowledged risk. Correctional facilities should provide detainees with routine opt-out HIV testing, unless the prevalence of previously undiagnosed HIV infection has been documented to be less than 0.1%. (Am J Public Health. 2012;102:S201-S204. doi:10.2105/AJPH.2011.300614) C1 [VanHandel, Michelle; Beltrami, John F.] Ctr Dis Control & Prevent, Natl Ctr HIVAIDS Viral Hepatitis STD & TB Prevent, Div HIVAIDS Prevent, Program Evaluat Branch, Atlanta, GA USA. [MacGowan, Robin J.; Margolis, Andrew D.] Ctr Dis Control & Prevent, Natl Ctr HIVAIDS Viral Hepatitis STD & TB Prevent, Div HIVAIDS Prevent, Prevent Res Branch, Atlanta, GA USA. [Borkowf, Craig B.] Ctr Dis Control & Prevent, Natl Ctr HIVAIDS Viral Hepatitis STD & TB Prevent, Div HIVAIDS Prevent, Quantitat Sci & Data Management Branch, Atlanta, GA USA. RP VanHandel, M (reprint author), 1600 Clifton Rd NE,Mail Stop E-59, Atlanta, GA 30333 USA. EM ioq4@cdc.gov NR 26 TC 12 Z9 12 U1 0 U2 3 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PY 2012 VL 102 SU 2 BP S201 EP S204 DI 10.2105/AJPH.2011.300614 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 928FV UT WOS:000302969500012 PM 22401522 ER PT J AU Hard, DL AF Hard, David L. TI Partnering Strategies for Childhood Agricultural Safety and Health SO JOURNAL OF AGROMEDICINE LA English DT Article DE Agriculture; child; injuries AB The National Institute for Occupational Safety and Health (NIOSH) has been the lead federal agency of the national Childhood Agricultural Injury Prevention Initiative (CAIPI) since the program's inception in 1996 and in this role, collaborated with numerous partners in childhood agricultural injury prevention activities. This collaboration has likely helped achieve the current reduction in childhood agricultural injury. The paper looks at existing groups with past and current childhood agricultural injury prevention activities for partnering strategies that could contribute to reducing the morbidity and mortality of childhood agricultural injuries. Based upon the review, suggestions are made for future partnering strategies to continue progress in this area. C1 NIOSH, Ctr Dis Control & Prevent, Div Safety Res, Anal & Field Evaluat Branch, Morgantown, WV 26505 USA. RP Hard, DL (reprint author), NIOSH, Ctr Dis Control & Prevent, Div Safety Res, Anal & Field Evaluat Branch, 1095 Willowdale Rd, Morgantown, WV 26505 USA. EM DHard@cdc.gov FU Intramural CDC HHS [CC999999] NR 6 TC 4 Z9 4 U1 0 U2 4 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1059-924X J9 J AGROMEDICINE JI J. Agromedicine PY 2012 VL 17 IS 2 SI SI BP 225 EP 231 DI 10.1080/1059924X.2012.658341 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 931KK UT WOS:000303214600014 PM 22490034 ER PT J AU McBride, CM Bowen, MS Shully, SD Khoury, MJ AF McBride, Colleen M. Bowen, M. Scott Shully, Sheri D. Khoury, Muin J. TI Introduction to the 4th National Conference on Genomics and Public Health SO PUBLIC HEALTH GENOMICS LA English DT Editorial Material C1 [McBride, Colleen M.] NHGRI, NIH, Bethesda, MD 20892 USA. [Bowen, M. Scott; Khoury, Muin J.] CDC, Off Publ Hlth Genom, Atlanta, GA 30333 USA. [Shully, Sheri D.] NCI, NIH, Bethesda, MD 20892 USA. [Khoury, Muin J.] NCI, NIH, Atlanta, GA USA. RP McBride, CM (reprint author), NHGRI, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1662-4246 J9 PUBLIC HEALTH GENOM JI Pub. Health Genomics PY 2012 VL 15 IS 3-4 BP 117 EP 117 DI 10.1159/000336597 PG 1 WC Genetics & Heredity; Public, Environmental & Occupational Health SC Genetics & Heredity; Public, Environmental & Occupational Health GA 932CJ UT WOS:000303267500001 PM 22488452 ER PT J AU Zimmern, RL Khoury, MJ AF Zimmern, R. L. Khoury, M. J. TI The Impact of Genomics on Public Health Practice: The Case for Change SO PUBLIC HEALTH GENOMICS LA English DT Article DE Genetics; Genomics; Health policy; Personalised medicine; Public health; Translation ID POPULATION HEALTH; MEDICINE GENOMICS AB Public health practice will not be able in the 21st century to ignore the impact of genomics, cell and molecular biology. It will need to take into consideration issues that include, among others: the complementary nature of social and biological models of disease, genetic exceptionalism, the readiness of public and patient to respond to genomic information, the relationship between individuals and populations, and concepts of population stratification. Health systems will need to adapt their practice and organisation to include new sequencing technologies, bioinformatic expertise and proper evaluation of genetic and molecular tests. Links with the commercial sector will increase in importance. The impact on developing countries cannot be ignored and will require special attention. Copyright (c) 2012 S. Karger AG, Basel C1 [Zimmern, R. L.] Fdn Genom & Populat Hlth, Cambridge CB1 8RN, England. [Khoury, M. J.] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. [Khoury, M. J.] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA USA. RP Zimmern, RL (reprint author), Fdn Genom & Populat Hlth, 2 Worts Causeway, Cambridge CB1 8RN, England. EM ron.zimmern@phgfoundation.org NR 30 TC 16 Z9 16 U1 1 U2 6 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1662-4246 J9 PUBLIC HEALTH GENOM JI Pub. Health Genomics PY 2012 VL 15 IS 3-4 BP 118 EP 124 DI 10.1159/000334840 PG 7 WC Genetics & Heredity; Public, Environmental & Occupational Health SC Genetics & Heredity; Public, Environmental & Occupational Health GA 932CJ UT WOS:000303267500002 PM 22488453 ER PT J AU Hesse, BW Arora, NK Khoury, MJ AF Hesse, B. W. Arora, N. K. Khoury, M. J. TI Implications of Internet Availability of Genomic Information for Public Health Practice SO PUBLIC HEALTH GENOMICS LA English DT Article DE Direct-to-consumer advertising; Health communication; Internet; Self-regulation ID PERSONALIZED MEDICINE; GENETIC INFORMATION; CONSUMERS; CARE; PARTICIPATION; APOMEDIATION; BEHAVIOR; SEARCH; IMPACT; AGENDA AB Tensions in the field have emerged over how best to communicate to the public about genomic discoveries in an era of direct-to-consumer (DTC) DNA testing services available through the Internet. Concerns over what the psychological and behavioral response might be to a nuanced, multiplex risk message have spurred some to offer caution in communicating to the public about personalized risk until the necessary research has been completed on how to communicate effectively. The popularization of DTC testing services, along with a spreading Internet culture on transparency for personal data, may make 'waiting to communicate' a moot point. To steer communication efforts in the midst of increasing access to personal genomic information, a self-regulation framework is presented. The framework emphasizes the importance of presenting a coherent message in all communiques about public health genomics. Coherence should be based on an evidence-based model of how the public processes information about health conditions and an emphasis on risk-to-action links. Recommendations from the President's Council of Advisors for Science and Technology are reviewed as a way of identifying targets of opportunity for structured communications both within the healthcare system and in the broader external ecosystem of publicly available health information technologies. Copyright (c) 2012 S. Karger AG, Basel C1 [Hesse, B. W.; Arora, N. K.; Khoury, M. J.] NCI, NIH, Bethesda, MD 20892 USA. [Khoury, M. J.] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA USA. RP Hesse, BW (reprint author), NCI, NIH, 6130 Execut Blvd,MSC 7365, Bethesda, MD 20892 USA. EM hesseb@mail.nih.gov OI Hesse, Bradford/0000-0003-1142-1161 NR 71 TC 4 Z9 6 U1 2 U2 11 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1662-4246 EI 1662-8063 J9 PUBLIC HEALTH GENOM JI Pub. Health Genomics PY 2012 VL 15 IS 3-4 BP 201 EP 208 DI 10.1159/000335892 PG 8 WC Genetics & Heredity; Public, Environmental & Occupational Health SC Genetics & Heredity; Public, Environmental & Occupational Health GA 932CJ UT WOS:000303267500012 PM 22488463 ER PT J AU Li, CY Ford, ES Zhao, GX Tsai, J Balluz, LS Giles, WH AF Li, Chaoyang Ford, Earl S. Zhao, Guixiang Tsai, James Balluz, Lina S. Giles, Wayne H. TI Trends of insulin use among US adults with type 2 diabetes: the Behavioral Risk Factor Surveillance System, 1995-2007 SO JOURNAL OF DIABETES AND ITS COMPLICATIONS LA English DT Article DE Diabetes; Insulin therapy; Prevalence; Trend; Race/ethnicity ID PHYSICAL-ACTIVITY; GLYCEMIC CONTROL; CARDIOVASCULAR-DISEASE; GLUCOSE CONTROL; THERAPY; MELLITUS; PREVALENCE; RESISTANCE; BURDEN; COMPLICATIONS AB Objective: People with type 2 diabetes may need insulin therapy to compensate for their underlying pathogenic abnormalities and to improve glycemic control. We examined trends of insulin use among US adults aged >= 40 years with type 2 diabetes. Methods: We analyzed data from the Behavioral Risk Factor Surveillance System collected annually during 1995-2007. Insulin use was assessed by self-report. Log-linear regression analyses with a robust error variance estimator were performed to estimate the prevalence, prevalence ratios, and their 95% confidence intervals. Results: The overall crude and age-standardized proportion of insulin use decreased from 35% and 36% in 1995 to 23% and 22% in 2007, respectively. After adjustments for age, sex, race/ethnicity, education attainment, body mass index, and diabetes duration, the overall prevalence decreased from 33% to 22% (P<.0001 for linear trend). The decreasing rates were similar across sex (P=.23 for interaction between sex and survey year) and race/ethnicity (P=.35 for interaction between race/ethnicity and survey year). Conclusion: The proportion of insulin use decreased from 1995 to 2007 among US adults aged >= 40 years. Continuing efforts may be needed to properly identify those who may need to initiate and maintain insulin therapy among patients with type 2 diabetes as medically indicated. Published by Elsevier Inc. C1 [Li, Chaoyang; Zhao, Guixiang; Balluz, Lina S.] Ctr Dis Control & Prevent, Div Behav Surveillance, Off Surveillance Epidemiol & Lab Serv, Atlanta, GA 30333 USA. [Ford, Earl S.; Giles, Wayne H.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Tsai, James] Ctr Dis Control & Prevent, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Li, CY (reprint author), Ctr Dis Control & Prevent, Div Behav Surveillance, Off Surveillance Epidemiol & Lab Serv, Atlanta, GA 30333 USA. EM cli@cdc.gov NR 44 TC 8 Z9 8 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1056-8727 J9 J DIABETES COMPLICAT JI J. Diabetes Complications PD JAN-FEB PY 2012 VL 26 IS 1 BP 17 EP 22 DI 10.1016/j.jdiacomp.2011.11.005 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 925JZ UT WOS:000302758800003 PM 22226485 ER PT J AU Boneberger, A Ruckinger, S Guthold, R Kann, L Riley, L AF Boneberger, Anja Rueckinger, Simon Guthold, Regina Kann, Laura Riley, Leanne TI HIV/AIDS related knowledge among school-going adolescents from the Middle East and North Africa SO SEXUAL HEALTH LA English DT Article DE global school-based student health survey; sexual education; sexual knowledge ID YOUNG-PEOPLE; REPRODUCTIVE HEALTH; ATTITUDES; COUNTRIES; STUDENTS; BEHAVIOR; AIDS AB The aim of this secondary analysis was to present cross-national data about HIV/AIDS related knowledge among 13- to 15-year-old school-going adolescents from the Middle East and North Africa. Data from 23 673 school-going adolescents from seven countries (Jordan, Lebanon, Libyan Arab Jamahiriya, Morocco, Oman, Tunisia and United Arab Emirates) that undertook the Global School-Based Student Health Survey between 2004 and 2008 were analysed. HIV/AIDS related knowledge varied significantly between countries and gender. Research for this sensitive topic is scarce in this region. In addition, schools could be among the many key players for HIV/AIDS education. C1 [Boneberger, Anja] Univ Hosp Munich LMU, Inst & Outpatient Clin Occupat Social & Environm, D-80336 Munich, Germany. [Rueckinger, Simon] Univ Munich, Inst Social Pediat & Adolescent Med, D-81377 Munich, Germany. [Guthold, Regina; Riley, Leanne] World Hlth Org, Dept Chron Dis & Hlth Promot, CH-1211 Geneva, Switzerland. [Kann, Laura] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. RP Boneberger, A (reprint author), Univ Hosp Munich LMU, Inst & Outpatient Clin Occupat Social & Environm, D-80336 Munich, Germany. EM anja.boneberger@med.uni-muenchen.de NR 15 TC 1 Z9 1 U1 0 U2 6 PU CSIRO PUBLISHING PI CLAYTON PA UNIPARK, BLDG 1, LEVEL 1, 195 WELLINGTON RD, LOCKED BAG 10, CLAYTON, VIC 3168, AUSTRALIA SN 1448-5028 EI 1449-8987 J9 SEX HEALTH JI Sex Health PY 2012 VL 9 IS 2 BP 196 EP 198 DI 10.1071/SH11054 PG 3 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 925WU UT WOS:000302793600016 PM 22498168 ER PT J AU Williams, AF West, BA Shults, RA AF Williams, Allan F. West, Bethany A. Shults, Ruth A. TI Fatal Crashes of 16-to 17-Year-Old Drivers Involving Alcohol, Nighttime Driving, and Passengers SO TRAFFIC INJURY PREVENTION LA English DT Article DE Young driver; Fatal crash; Alcohol impaired ID TEENAGE DRIVERS; LICENSING PROGRAM; RISK; 16-YEAR-OLD; INVOLVEMENT; AGE AB Objective: The objective of this study was to provide a contemporary analysis of the alcohol-impaired driving problem among 16- to 17-year-olds and to consider the potential role of night and passenger restrictions in dealing with the alcohol problem by determining how many of the alcohol-related crashes take place at night or with passengers. Methods: The data were derived from the Fatality Analysis Reporting System for 16- to 17-year-old passenger vehicle drivers in fatal crashes during 2005-2009. Results: During the 5-year period, 15 percent of the 8664 16- to 17-year-old drivers in fatal crashes had positive blood alcohol concentrations, most of which were 0.08 percent or greater. Drivers in alcohol-related crashes were more likely than those in non-alcohol-related crashes to be male, unbelted, in single vehicles, and speeding, and their crashes were more likely to occur on Saturday or Sunday, at night, and when passengers were present. Of the alcohol-related crashes, 88 percent took place at night or with passengers present or both, as did 67 percent of the non-alcohol-related crashes. Conclusions: Stronger night and passenger restrictions with increased compliance and greater application of alcohol-specific policies would likely be effective in reducing the alcohol-related and non-alcohol-related crashes of 16- to 17-year-olds. Increasing the licensing age beyond age 16 would supplement the effectiveness of these actions. C1 [Williams, Allan F.] Allan F Williams LLC, Bethesda, MD USA. [West, Bethany A.; Shults, Ruth A.] Ctr Dis Control & Prevent, Div Unintent Injury Prevent, Atlanta, GA USA. RP Williams, AF (reprint author), 8200 Beech Tree Rd, Bethesda, MD 20817 USA. EM allan.f.williams@gmail.com FU National Center for Injury Prevention and Control, Centers for Disease Control and Prevention FX We thank Tonja Lindsey of the National Highway Traffic Safety Administration for providing the data for this article. This work was supported by a grant from the National Center for Injury Prevention and Control, Centers for Disease Control and Prevention. The findings and conclusions in this article are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 35 TC 7 Z9 7 U1 0 U2 6 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1538-9588 J9 TRAFFIC INJ PREV JI Traffic Inj. Prev. PY 2012 VL 13 IS 1 BP 1 EP 6 DI 10.1080/15389588.2011.633235 PG 6 WC Public, Environmental & Occupational Health; Transportation SC Public, Environmental & Occupational Health; Transportation GA 921PZ UT WOS:000302490900001 PM 22239137 ER PT J AU Harwood, EM Horvath, KJ Courtenay-Quirk, C Fisher, H Kachur, R McFarlane, M Meyer, B Rosser, BRS O'Leary, A AF Harwood, Eileen M. Horvath, Keith J. Courtenay-Quirk, Cari Fisher, Holly Kachur, Rachel McFarlane, Mary Meyer, Bryn Rosser, B. R. Simon O'Leary, Ann TI Sampling hidden populations: lessons learned from a telephone-based study of persons recently diagnosed with HIV (PRDH) SO INTERNATIONAL JOURNAL OF SOCIAL RESEARCH METHODOLOGY LA English DT Article DE hidden populations; subject recruitment; HIV; venue sampling; chain-referral sampling; qualitative methodology ID TO-REACH POPULATIONS; RISK; MEN; SEX AB This paper describes a flexible, multi-stage, nonprobability sampling process used in a study of persons recently diagnosed as HIV-positive (PRDH). From July 2007 to June 2008, we used venue and chain-referral sampling strategies to recruit PRDH in the US. We sought equal distributions (n = 20) of eligible PRDH from four self-identified subgroups: gay or bisexual men (GBM), heterosexual men (HM), heterosexual women (HW), and male-to-female transgender women (TGW). We categorized 30 sampling venues as websites, health clinics, or other networks. For 359 volunteer respondents, website venues proved more productive compared to health clinics and other sources. Website venues were most efficient for sampling recently diagnosed GBM and HW. Passive sampling methods were less effective in recruiting HM and TGW. Sampling approaches should be flexible and tailored to reach sub-categories within hidden populations. The sampling process itself produced valuable knowledge about social networks of hidden HIV populations. C1 [Harwood, Eileen M.] Univ Minnesota, Div Epidemiol & Community Hlth, Sch Publ Hlth, Minneapolis, MN 55454 USA. [Courtenay-Quirk, Cari; Fisher, Holly; O'Leary, Ann] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. [Kachur, Rachel; McFarlane, Mary] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA USA. RP Harwood, EM (reprint author), Univ Minnesota, Div Epidemiol & Community Hlth, Sch Publ Hlth, 1300 S 2nd St,Suite 300, Minneapolis, MN 55454 USA. EM harwo002@umn.edu NR 21 TC 0 Z9 0 U1 0 U2 4 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1364-5579 J9 INT J SOC RES METHOD JI Int. J. Soc. Res. Methodol. PY 2012 VL 15 IS 1 BP 31 EP 40 DI 10.1080/02650533.2011.573302 PG 10 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA 917JR UT WOS:000302171200003 ER PT J AU Talbot, EA Harland, D Wieland-Alter, W Burrer, S Adams, LV AF Talbot, Elizabeth A. Harland, Dawn Wieland-Alter, Wendy Burrer, Sherry Adams, Lisa V. TI Specificity of the Tuberculin Skin Test and the T-SPOT.TB Assay Among Students in a Low-Tuberculosis Incidence Setting SO JOURNAL OF AMERICAN COLLEGE HEALTH LA English DT Article DE interferon-gamma release assay; Mycobacterium tuberculosis; student health; tuberculin skin test AB Objective: Interferon-gamma release assays (IGRAs) are an important tool for detecting latent Mycobacterium tuberculosis infection (LTBI). Insufficient data exist about IGRA specificity in college health centers, most of which screen students for LTBI using the tuberculin skin test (TST). Participants: Students at a low-TB incidence college health center. Methods: TST and T-SPOT. TB were performed on prospectively recruited students. TB exposure risk was assessed using a questionnaire: Those at low risk were assumed to not have LTBI in order to calculate test specificity. Results: Of 184 students enrolled, 143 had results available for both TST and T-SPOT. TB. Agreement of the tests was 97% (kappa statistic 0.717; 95% confidence interval, 0.399-1.00). Among 124 low-risk students, specificity for TST and T-SPOT. TB were 98.4% and 100%, respectively. Conclusions: T-SPOT. TB specificity was high among low-risk students. Additional studies such as cost-effectiveness analyses using T-SPOT. TB as a single or confirmatory test to TST are needed to contribute to LTBI screening policy decisions. C1 [Talbot, Elizabeth A.; Wieland-Alter, Wendy; Adams, Lisa V.] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Hanover, NH 03756 USA. [Talbot, Elizabeth A.; Burrer, Sherry] Bur Dis Control, Dept Hlth & Human Serv, Concord, NH USA. [Harland, Dawn] Dartmouth Coll, Hlth Serv, Hanover, NH 03755 USA. [Burrer, Sherry] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. RP Talbot, EA (reprint author), Dartmouth Hitchcock Med Ctr, Sect Infect Dis & Int Hlth, 1 Med Ctr Dr, Lebanon, NH 03756 USA. EM elizabeth.talbot@dartmouth.edu NR 8 TC 7 Z9 7 U1 0 U2 2 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0744-8481 J9 J AM COLL HEALTH JI J. Am. Coll. Health PY 2012 VL 60 IS 1 BP 94 EP 96 DI 10.1080/07448481.2011.580029 PG 3 WC Education & Educational Research; Public, Environmental & Occupational Health SC Education & Educational Research; Public, Environmental & Occupational Health GA 917XE UT WOS:000302211100013 PM 22171735 ER PT J AU Keyes, CLM Eisenberg, D Perry, GS Dube, SR Kroenke, K Dhingra, SS AF Keyes, Corey L. M. Eisenberg, Daniel Perry, Geraldine S. Dube, Shanta R. Kroenke, Kurt Dhingra, Satvinder S. TI The Relationship of Level of Positive Mental Health With Current Mental Disorders in Predicting Suicidal Behavior and Academic Impairment in College Students SO JOURNAL OF AMERICAN COLLEGE HEALTH LA English DT Article DE flourishing; happiness; Mental Health Continuum-Short Form (MHC-SF); mental illness; Patient Health Questionnaire (PHQ); positive mental health; subjective well-being ID NATIONAL-COMORBIDITY-SURVEY; PRIMARY-CARE; PSYCHIATRIC-DISORDERS; PRIME-MD; QUESTIONNAIRE; DEPRESSION; VALIDITY; PREVALENCE; VALIDATION; UTILITY AB Objective: To investigate whether level of positive mental health complements mental illness in predicting students at risk for suicidal behavior and impaired academic performance. Participants: A sample of 5,689 college students participated in the 2007 Healthy Minds Study and completed an Internet survey that included the Mental Health Continuum-Short Form and the Patient Health Questionnaire screening scales for depression and anxiety disorders, questions about suicide ideation, plans, and attempts, and academic impairment. Results: Just under half (49.3%) of students were flourishing and did not screen positive for a mental disorder. Among students who did, and those who did not, screen for a mental disorder, suicidal behavior and impaired academic performance were lowest in those with flourishing, higher among those with moderate, and highest in those with languishing mental health. Conclusions: Positive mental health complements mental disorder screening in mental health surveillance and prediction of suicidal behavior and impairment of academic performance. C1 [Keyes, Corey L. M.] Emory Univ, Dept Sociol, Atlanta, GA 30322 USA. [Eisenberg, Daniel] Univ Michigan, Dept Hlth Management & Policy, Ann Arbor, MI 48109 USA. [Perry, Geraldine S.; Dhingra, Satvinder S.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Atlanta, GA USA. [Dube, Shanta R.] Ctr Dis Control & Prevent, Off Smoking & Hlth, Atlanta, GA USA. [Kroenke, Kurt] Indiana Univ Sch Med, Regenstrief Inst, Indianapolis, IN USA. [Kroenke, Kurt] Richard Roudebush VA HSR&D Ctr Excellence, Indianapolis, IN USA. RP Keyes, CLM (reprint author), Emory Univ, Dept Sociol, Room 225,Tarbutton Hall,1555 Dickey Dr, Atlanta, GA 30322 USA. EM ckeyes@emory.edu NR 36 TC 36 Z9 38 U1 1 U2 26 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0744-8481 J9 J AM COLL HEALTH JI J. Am. Coll. Health PY 2012 VL 60 IS 2 BP 126 EP 133 DI 10.1080/07448481.2011.608393 PG 8 WC Education & Educational Research; Public, Environmental & Occupational Health SC Education & Educational Research; Public, Environmental & Occupational Health GA 917XK UT WOS:000302211700004 PM 22316409 ER PT J AU Ceballos, DM Burr, GA AF Ceballos, Diana M. Burr, Gregory A. TI Evaluating a Persistent Nuisance Odor in an Office Building SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article C1 [Ceballos, Diana M.; Burr, Gregory A.] NIOSH, US Dept HHS, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. RP Ceballos, DM (reprint author), NIOSH, US Dept HHS, Ctr Dis Control & Prevent, 4676 Columbia Pkwy,MS R-11, Cincinnati, OH 45226 USA. EM DCeballos@cdc.gov FU Intramural CDC HHS [CC999999] NR 21 TC 0 Z9 0 U1 1 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1545-9624 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PD JAN PY 2012 VL 9 IS 1 BP D1 EP D6 DI 10.1080/15459624.2012.635131 PG 6 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 918SU UT WOS:000302272200001 PM 22150515 ER PT J AU Murashov, V Schulte, P Howard, J AF Murashov, Vladimir Schulte, Paul Howard, John TI Progression of Occupational Risk Management with Advances in Nanomaterials SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Editorial Material ID INHALATION EXPOSURE; GOLD NANOPARTICLES; CARBON NANOTUBES; NANOTECHNOLOGY; SIZE; PENETRATION; PARTICLES; PERSPECTIVE; NANODEVICE; CHALLENGE C1 [Murashov, Vladimir; Schulte, Paul; Howard, John] NIOSH, Ctr Dis Control & Prevent, Washington, DC 20201 USA. RP Murashov, V (reprint author), NIOSH, Ctr Dis Control & Prevent, 395 E St SW, Washington, DC 20201 USA. EM vmurashov@cdc.gov RI Murashov, Vladimir/K-5481-2012 NR 103 TC 7 Z9 8 U1 1 U2 13 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PD JAN PY 2012 VL 9 IS 1 BP D12 EP D22 DI 10.1080/15459624.2012.638217 PG 11 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 918SU UT WOS:000302272200003 PM 22150340 ER PT J AU Zhou, ZY Shi, GQ Fontaine, R Wei, K Feng, T Wang, F Wang, GQ Qu, Y Li, ZH Dong, ZJ Zhu, HJ Yang, ZL Zeng, G Liu, JK AF Zhou, Zhong-Yu Shi, Guo-Qing Fontaine, Robert Wei, Kun Feng, Tao Wang, Fang Wang, Gang-Qiang Qu, Yan Li, Zheng-Hui Dong, Ze-Jun Zhu, Hua-Jie Yang, Zhu-Liang Zeng, Guang Liu, Ji-Kai TI Evidence for the Natural Toxins from the Mushroom Trogia venenata as a Cause of Sudden Unexpected Death in Yunnan Province, China SO ANGEWANDTE CHEMIE-INTERNATIONAL EDITION LA English DT Article DE amino acids; mushrooms; natural products; toxicology ID GAMMA-GUANIDINOBUTYRIC ACID; METHYLENECYCLOPROPYLGLYCINE C1 [Shi, Guo-Qing; Fontaine, Robert; Zeng, Guang] Chinese Ctr Dis Control & Prevent, Beijing 100050, Peoples R China. [Zhou, Zhong-Yu; Wei, Kun; Feng, Tao; Wang, Fang; Wang, Gang-Qiang; Qu, Yan; Li, Zheng-Hui; Dong, Ze-Jun; Zhu, Hua-Jie; Yang, Zhu-Liang; Liu, Ji-Kai] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China. [Fontaine, Robert] US Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Zhou, Zhong-Yu] Chinese Acad Sci, S China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China. RP Zeng, G (reprint author), Chinese Ctr Dis Control & Prevent, Beijing 100050, Peoples R China. EM zeng4605@vip.sina.com; jkliu@mail.kib.ac.cn FU National Basic Research Program of China (973 Program) [2009CB522300]; National Natural Sciences Foundation of China [30830113, U1132607]; Ministry of Health [200802002] FX This project was supported by the National Basic Research Program of China (973 Program, 2009CB522300), the National Natural Sciences Foundation of China (30830113, U1132607), and Scientific Research Special Funds from the Ministry of Health (200802002). We thank Dr. R. Stone for reading our manuscript and for helpful suggestions. NR 17 TC 19 Z9 25 U1 5 U2 39 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 1433-7851 J9 ANGEW CHEM INT EDIT JI Angew. Chem.-Int. Edit. PY 2012 VL 51 IS 10 BP 2368 EP 2370 DI 10.1002/anie.201106502 PG 3 WC Chemistry, Multidisciplinary SC Chemistry GA 901AS UT WOS:000300934700011 PM 22287497 ER PT J AU Mumtaz, MM Ray, M Crowell, SR Keys, D Fisher, J Ruiz, P AF Mumtaz, M. Moiz Ray, Meredith Crowell, Susan R. Keys, Deborah Fisher, Jeffrey Ruiz, Patricia TI TRANSLATIONAL RESEARCH TO DEVELOP A HUMAN PBPK MODELS TOOL KIT-VOLATILE ORGANIC COMPOUNDS (VOCS) SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES LA English DT Article ID COMPLEX CHEMICAL-MIXTURES; HUMAN BIOMONITORING DATA; IN-VIVO EXTRAPOLATION; PHARMACOKINETIC MODEL; RISK-ASSESSMENT; CANCER-RISK; PERCUTANEOUS-ABSORPTION; CARBON-TETRACHLORIDE; LACTATIONAL TRANSFER; TOXICITY DATA AB Toxicity and exposure evaluations remain the two of the key components of human health assessment. While improvement in exposure assessment relies on a better understanding of human behavior patterns, toxicity assessment still relies to a great extent on animal toxicity testing and human epidemiological studies. Recent advances in computer modeling of the dose-response relationship and distribution of xenobiotics in humans to important target tissues have advanced our abilities to assess toxicity. In particular, physiologically based pharmacokinetic (PBPK) models are among the tools than can enhance toxicity assessment accuracy. Many PBPK models are available to the health assessor, but most are so difficult to use that health assessors rarely use them. To encourage their use these models need to have transparent and user-friendly formats. To this end the Agency for Toxic Substances and Disease Registry (ATSDR) is using translational research to increase PBPK model accessibility, understandability, and use in the site-specific health assessment arena. The agency has initiated development of a human PBPK tool-kit for certain high priority pollutants. The tool kit comprises a series of suitable models. The models are recoded in a single computer simulation language and evaluated for use by health assessors. While not necessarily being state-of-the-art code for each chemical, the models will be sufficiently accurate to use for screening purposes. This article presents a generic, seven-compartment PBPK model for six priority volatile organic compounds (VOCs): benzene (BEN), carbon tetrachloride (CCl4), dichloromethane (DCM), perchloroethylene (PCE), trichloroethylene (TCE), and vinyl chloride (VC). Limited comparisons of the generic and original model predictions to published kinetic data were conducted. A goodness of fit was determined by calculating the means of the sum of the squared differences (MSSDs) for simulation vs. experimental kinetic data using the generic and original models. Using simplified solvent exposure assumptions for oral ingestion and inhalation, steady-state blood concentrations of each solvent were simulated for exposures equivalent to the ATSDR Minimal Risk Levels (MRLs). The predicted blood levels were then compared to those reported in the National Health and Nutrition Examination Survey (NHANES). With the notable exception of BEN, simulations of combined oral and inhalation MRLs using our generic VOC model yielded blood concentrations well above those reported for the 95th percentile blood concentrations for the U. S. populations, suggesting no health concerns. When the PBPK tool kit is fully developed, risk assessors will have a readily accessible tool for evaluating human exposure to a variety of environmental pollutants. C1 [Mumtaz, M. Moiz] ATSDR, Computat Toxicol Lab, Div Toxicol & Environm Med, Atlanta, GA 30333 USA. [Ray, Meredith] Univ S Carolina, Charleston, SC USA. [Crowell, Susan R.] Pacific NW Natl Lab, Richland, WA USA. [Keys, Deborah] Univ Georgia, Athens, GA 30602 USA. [Fisher, Jeffrey] US FDA, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA. RP Mumtaz, MM (reprint author), ATSDR, Computat Toxicol Lab, Div Toxicol & Environm Med, 1600 Clifton Rd,F-62, Atlanta, GA 30333 USA. EM mgm4@cdc.gov NR 60 TC 9 Z9 9 U1 3 U2 15 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1528-7394 J9 J TOXICOL ENV HEAL A JI J. Toxicol. Env. Health Part A PY 2012 VL 75 IS 1 BP 6 EP 24 DI 10.1080/15287394.2012.625546 PG 19 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 917NJ UT WOS:000302184200002 PM 22047160 ER PT J AU Moorman, WJ Reutman, SS Shaw, PB Blade, LM Marlow, D Vesper, H Clark, JC Schrader, SM AF Moorman, William J. Reutman, Susan S. Shaw, Peter B. Blade, Leo Michael Marlow, David Vesper, Hubert Clark, John C. Schrader, Steven M. TI OCCUPATIONAL EXPOSURE TO ACRYLAMIDE IN CLOSED SYSTEM PRODUCTION PLANTS: AIR LEVELS AND BIOMONITORING SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES LA English DT Article ID HEMOGLOBIN ADDUCTS; BIOMARKERS; WORKERS; SMOKING AB The aim of this study was to evaluate biomarkers of acrylamide exposure, including hemoglobin adducts and urinary metabolites in acrylamide production workers. Biomarkers are integrated measures of the internal dose, and it is total acrylamide dose from all routes and sources that may present health risks. Workers from three companies were studied. Workers potentially exposed to acrylamide monomer wore personal breathing-zone air samplers. Air samples and surface-wipe samples were collected and analyzed for acrylamide. General-area air samples were collected in chemical processing units and control rooms. Hemoglobin adducts were isolated from ethylenediamine teraacetic acid (EDTA)-whole blood, and adducts of acrylamide and glycidamide, at the N-terminal valines of hemoglobin, were cleaved from the protein chain by use of a modified Edman reaction. Full work-shift, personal breathing zone, and general-area air samples were collected and analyzed for particulate and acrylamide monomer vapor. The highest general-area concentration of acrylamide vapor was 350 mu g/cm(3) in monomer production. Personal breathing zone and general-area concentrations of acrylamide vapor were found to be highest in monomer production operations, and lower levels were in the polymer production operations. Adduct levels varied widely among workers, with the highest in workers in the monomer and polymer production areas. The acrylamide adduct range was 15-1884 pmol/g; glycidamide adducts ranged from 17.8 to 1376 p/mol/g. The highest acrylamide and glycidamide adduct levels were found among monomer production process operators. The primary urinary metabolite N-acetyl-S-(2-carbamoylethyl) cysteine (NACEC) ranged from the limit of detection to 15.4 mu g/ml. Correlation of workplace exposure and sentinel health effects is needed to determine and control safe levels of exposure for regulatory standards. C1 [Moorman, William J.; Reutman, Susan S.; Shaw, Peter B.; Marlow, David; Clark, John C.; Schrader, Steven M.] CDC NIOSH, DART, EPHB, Cincinnati, OH USA. [Blade, Leo Michael] CDC NIOSH, DART EPHP, Cincinnati, OH USA. [Vesper, Hubert] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Moorman, WJ (reprint author), NIOSH, DART, 4676 Columbia Pkwy, Cincinnati, OH 45226 USA. EM wjm2@cdc.gov NR 18 TC 6 Z9 6 U1 2 U2 10 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1528-7394 J9 J TOXICOL ENV HEAL A JI J. Toxicol. Env. Health Part A PY 2012 VL 75 IS 2 BP 100 EP 111 DI 10.1080/15287394.2011.615109 PG 12 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 917NK UT WOS:000302184400003 PM 22129237 ER PT J AU Chisholm, WP Lee, T Slaven, JE Nelson, J Harper, M AF Chisholm, William P. Lee, Taekhee Slaven, James E. Nelson, John Harper, Martin TI Comparison of Filter and Wall Deposits From Samplers Used to Collect Airborne Lead-Containing Dusts at Field Sites SO AEROSOL SCIENCE AND TECHNOLOGY LA English DT Article ID WET CHEMICAL-ANALYSIS; X-RAY-FLUORESCENCE; PERSONAL SAMPLERS; PORTABLE XRF; AIR FILTERS; PERFORMANCE; PARTICLES; CASSETTES AB Pairs of Institute of Occupational Medicine (IOM) and 37 mm closed face cassette samplers (CFC) were deployed where occupational exposures to lead-containing dusts were known to occur. Discrete particle analyses of wall and filter deposits were performed by Scanning Electron Microscopy-Energy Dispersive X-ray Spectrometry (SEM-EDX). From the elemental composition and projected area diameter of each particle a density, volume, and mass were calculated, and a mass-weighted size distribution for each filter and corresponding wall deposit determined. Comparison of pairs of wall and filter mass-weighted size distributions by Mann-Whitney statistical analysis shows that in only 3 of 72 examples from either sampler were the distributions significantly different that suggests that the mechanisms of particle deposition on the sampler walls for particles in this size range (0.5 mu m through 20 mu m) do not differ for the different samplers. Furthermore, in only 4 of 33 sampler pairs did the IOM and CFC results differ. Although these results originate from several distinct processes characterized by different chemical and physical dust generation mechanisms, they suggest that in these environments the measurement of "total dust" by the CFC and inhalable dust by the IOM will be very similar when both samplers are processed the same way with respect to the including or excluding wall deposits with the filter catch. However, these results may not be applicable to environments where larger particles exist. C1 [Chisholm, William P.; Lee, Taekhee; Nelson, John; Harper, Martin] NIOSH, Exposure Assessment Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV USA. [Slaven, James E.] Indiana Univ, Sch Med, Dept Biostat, Indianapolis, IN USA. RP Chisholm, WP (reprint author), 1095 Willowdale Rd M-S L-3030, Morgantown, WV 26505 USA. EM wchisholm@cdc.gov NR 21 TC 6 Z9 6 U1 0 U2 5 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0278-6826 J9 AEROSOL SCI TECH JI Aerosol Sci. Technol. PY 2012 VL 46 IS 4 BP 411 EP 418 DI 10.1080/02786826.2011.635726 PG 8 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 912CG UT WOS:000301771600005 ER PT J AU Ku, BK Evans, DE AF Ku, Bon Ki Evans, Douglas E. TI Investigation of Aerosol Surface Area Estimation from Number and Mass Concentration Measurements: Particle Density Effect SO AEROSOL SCIENCE AND TECHNOLOGY LA English DT Article ID MOBILITY ANALYSIS; SIZE; NANOPARTICLES; PARAMETERS; MORPHOLOGY; EXPOSURE AB For nanoparticles with nonspherical morphologies, e.g., open agglomerates or fibrous particles, it is expected that the actual density of agglomerates may be significantly different from the bulk material density. It is further expected that using the material density may upset the relationship between surface area and mass when a method for estimating aerosol surface area from number and mass concentrations (referred to as "Maynard's estimation method") is used. Therefore, it is necessary to quantitatively investigate how much the Maynard's estimation method depends on particle morphology and density. In this study, aerosol surface area estimated from number and mass concentration measurements was evaluated and compared with values from two reference methods: a method proposed by Lall and Friedlander for agglomerates and a mobility based method for compact nonspherical particles using well-defined polydisperse aerosols with known particle densities. Polydisperse silver aerosol particles were generated by an aerosol generation facility. Generated aerosols had a range of morphologies, count median diameters (CMD) between 25 and 50 nm, and geometric standard deviations (GSD) between 1.5 and 1.8. The surface area estimates from number and mass concentration measurements correlated well with the two reference values when gravimetric mass was used. The aerosol surface area estimates from the Maynard's estimation method were comparable to the reference method for all particle morphologies within the surface area ratios of 3.31 and 0.19 for assumed GSDs 1.5 and 1.8, respectively, when the bulk material density of silver was used. The difference between the Maynard's estimation method and surface area measured by the reference method for fractal-like agglomerates decreased from 79% to 23% when the measured effective particle density was used, while the difference for nearly spherical particles decreased from 30% to 24%. The results indicate that the use of particle density of agglomerates improves the accuracy of the Maynard's estimation method and that an effective density should be taken into account, when known, when estimating aerosol surface area of nonspherical aerosol such as open agglomerates and fibrous particles. C1 [Ku, Bon Ki; Evans, Douglas E.] NIOSH, Ctr Dis Control & Prevent CDC, Cincinnati, OH 45226 USA. RP Ku, BK (reprint author), NIOSH, Ctr Dis Control & Prevent CDC, 4676 Columbia Pkwy,MS-R3, Cincinnati, OH 45226 USA. EM BKu@cdc.gov FU NIOSH through the Nanotechnology Research Center (NTRC) [CAN 927ZBCL] FX The authors would like to thank Dr. Andrew Maynard, School of Public Health at the University of Michigan; Dr. Aleks Stefaniak, Division of Respiratory Disease Studies (DRDS)/National Institute for Occupational Safety and Health (NIOSH) in Morgantown, WV, for his invaluable comments and suggestions on this work; and Ellen Galloway for editorial assistance. This work was funded by the NIOSH through the Nanotechnology Research Center (NTRC) program (project CAN 927ZBCL). NR 30 TC 3 Z9 3 U1 1 U2 11 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0278-6826 J9 AEROSOL SCI TECH JI Aerosol Sci. Technol. PY 2012 VL 46 IS 4 BP 473 EP 484 DI 10.1080/02786826.2011.639316 PG 12 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 912CG UT WOS:000301771600011 PM 26526560 ER PT J AU Mackenzie, S Pearson, C Frye, V Gomez, CA Latka, MH Purcell, DW Knowlton, AR Metsch, LR Tobin, KE Valverde, EE Knight, KR AF Mackenzie, Sonja Pearson, Charles Frye, Victoria Gomez, Cynthia A. Latka, Mary H. Purcell, David W. Knowlton, Amy R. Metsch, Lisa R. Tobin, Karin E. Valverde, Eduardo E. Knight, Kelly R. TI Agents of Change: Peer Mentorship as HIV Prevention Among HIV-Positive Injection Drug Users SO SUBSTANCE USE & MISUSE LA English DT Article DE change agent; identity; peer mentor; risk environment; social context; social identity; HIV prevention; HIV-positive; injection drug user ID STRUCTURAL INTERVENTIONS; HEPATITIS-C; RISK; DISCLOSURE; REDUCE; TRIAL; CONSEQUENCES; ADHERENCE; OUTREACH; IDENTITY AB This paper presents a qualitative investigation of peer mentoring among HIV seropositive injection drug users in a randomized controlled trial, the INSPIRE study. Qualitative analyses of 68 in-depth open-ended interviews conducted in 2005 in Baltimore, New York, Miami, and San Francisco revealed that these individuals conceptualized themselves as change agents through the identity of peer mentor at the three related domains of individual, interpersonal, and community-level change. Implications for program development and future research of peer mentoring as a mechanism for HIV prevention are discussed. This study was funded by the Centers for Disease Control and Prevention and Health Resources and Services Administration (HRSA). C1 [Mackenzie, Sonja; Gomez, Cynthia A.] San Francisco State Univ, Hlth Equ Inst, San Francisco, CA 94132 USA. [Pearson, Charles] Univ Calif San Francisco, Ctr AIDS Prevent Studies, San Francisco, CA 94143 USA. [Frye, Victoria] New York Blood Ctr, Lindsley F Kimball Res Inst, Lab Social & Behav Sci, New York, NY 10021 USA. [Frye, Victoria] Columbia Univ, Dept Sociomed Sci, Mailman Sch Publ Hlth, New York, NY USA. [Latka, Mary H.] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY USA. [Latka, Mary H.] Aurum Inst, Johannesburg, South Africa. [Purcell, David W.; Valverde, Eduardo E.] Ctr Dis Control & Prevent, Prevent Res Branch, Div HIV AIDS Prevent, Atlanta, GA USA. [Knowlton, Amy R.; Tobin, Karin E.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Behav & Soc, Baltimore, MD USA. [Metsch, Lisa R.] Univ Miami, Miller Sch Med, Div Hlth Serv Res & Policy, Miami, FL 33136 USA. [Knight, Kelly R.] Univ Calif San Francisco, Dept Anthropol Hist & Social Med, Posit Hlth Program, San Francisco, CA 94143 USA. [Metsch, Lisa R.] Univ Miami, Miller Sch Med, NIAID Funded Dev Ctr AIDS Res, Miami, FL 33136 USA. [Valverde, Eduardo E.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Behav & Clin Surveillance Branch, Atlanta, GA USA. [Knight, Kelly R.] Univ Calif San Francisco, Dept Med, Posit Hlth Program, San Francisco, CA USA. RP Mackenzie, S (reprint author), San Francisco State Univ, Hlth Equ Inst, 1600 Holloway Ave,EP 406, San Francisco, CA 94132 USA. EM smackenz@sfsu.edu OI Purcell, David/0000-0001-8125-5168 NR 38 TC 3 Z9 3 U1 0 U2 5 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1082-6084 EI 1532-2491 J9 SUBST USE MISUSE JI Subst. Use Misuse PY 2012 VL 47 IS 5 BP 522 EP 534 DI 10.3109/10826084.2012.644122 PG 13 WC Substance Abuse; Psychiatry; Psychology SC Substance Abuse; Psychiatry; Psychology GA 911UX UT WOS:000301746200007 PM 22428820 ER PT J AU Zibbell, JE AF Zibbell, Jon E. TI Caught Between the "Soft" and "Hard" Arms of the State: A Conceptual Apparatus for Situating the Formative Role of Drug User Organizations in National Policy-Making and Local Service Delivery - A Commentary SO SUBSTANCE USE & MISUSE LA English DT Editorial Material ID AIDS C1 [Zibbell, Jon E.] Skidmore Coll, Dept Anthropol, Saratoga Springs, NY 12866 USA. RP Zibbell, JE (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, 1600 Clifton Rd NE, Atlanta, GA 30329 USA. EM jzibbell@cdc.gov NR 18 TC 1 Z9 1 U1 0 U2 2 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1082-6084 J9 SUBST USE MISUSE JI Subst. Use Misuse PY 2012 VL 47 IS 5 BP 558 EP 565 DI 10.3109/10826084.2012.644125 PG 8 WC Substance Abuse; Psychiatry; Psychology SC Substance Abuse; Psychiatry; Psychology GA 911UX UT WOS:000301746200011 PM 22428824 ER PT J AU Hwang, GM Mahoney, PJ James, JH Lin, GC Berro, AD Keybl, MA Goedecke, DM Mathieu, JJ Wilson, T AF Hwang, Grace M. Mahoney, Paula J. James, John H. Lin, Gene C. Berro, Andre D. Keybl, Meredith A. Goedecke, D. Michael Mathieu, Jennifer J. Wilson, Todd TI A model-based tool to predict the propagation of infectious disease via airports SO TRAVEL MEDICINE AND INFECTIOUS DISEASE LA English DT Article DE Influenza transmission; Susceptible-exposed-infectious-recovered (SEIR) disease-spread; modeling; Public health aviation screening; Pandemic response; Points of entry ID A H1N1 VIRUS; PANDEMIC INFLUENZA; INTERNATIONAL AIRPORT; TRAVEL RESTRICTIONS; GEOGRAPHIC SPREAD; UNITED-STATES; TRANSMISSIBILITY; STRATEGIES; IMPACT AB Epidemics of novel or re-emerging infectious diseases have quickly spread globally via air travel, as highlighted by pandemic H1N1 influenza in 2009 (pH1N1). Federal, state, and local public health responders must be able to plan for and respond to these events at aviation points of entry. The emergence of a novel influenza virus and its spread to the United States were simulated for February 2009 from 55 international metropolitan areas using three basic reproduction numbers (R0): 1.53, 1.70, and 1.90. Empirical data from the pH1N1 virus were used to validate our SEIR model. Time to entry to the U.S. during the early stages of a prototypical novel communicable disease was predicted based on the aviation network patterns and the epidemiology of the disease. For example, approximately 96% of origins (R-0 of 1.53) propagated a disease into the U.S. in under 75 days, 90% of these origins propagated a disease in under 50 days. An R-0 of 1.53 reproduced the pH1NI observations. The ability to anticipate the rate and location of disease introduction into the U.S. provides greater opportunity to plan responses based on the scenario as it is unfolding. This simulation tool can aid public health officials to assess risk and leverage resources efficiently. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Hwang, Grace M.] Mitre Corp, Woodlawn, MD 21244 USA. [Mahoney, Paula J.; James, John H.; Keybl, Meredith A.; Mathieu, Jennifer J.] Mitre Corp, Bedford, MA 01730 USA. [Lin, Gene C.] Mitre Corp, Mclean, VA USA. [Berro, Andre D.] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine CDC DGMQ, San Francisco, CA USA. [Goedecke, D. Michael] RTI Int, Res Triangle Pk, NC USA. [Wilson, Todd] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA USA. RP Hwang, GM (reprint author), Mitre Corp, 2275 Rolling Run Dr, Woodlawn, MD 21244 USA. EM gmhwang@mitre.org OI Hwang, Grace/0000-0002-3335-8688 FU MITRE Corporation [200-2010-F-37011, 82209]; NIGMS [U01 GM070698] FX This research was funded by The MITRE Corporation's BioThreat Aircraft Warning System project and HHS/CDC/ DGMQ Purchase Order 200-2010-F-37011. Dr. Goedecke of RTI International was partially funded by the Models of Infectious Disease Agent Study (MIDAS) Cooperative Agreement from NIGMS (U01 GM070698) and by The MITRE Corporation under Research Agreement # 82209. The authors thank Tonia Korves and Nicki Cohen for critically reviewing the manuscript. Dr. Hwang received financial salary supported from Rick Sciambi, John Piescik, and Alan Moore. NR 43 TC 5 Z9 5 U1 2 U2 21 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1477-8939 J9 TRAVEL MED INFECT DI JI Travel Med. Infect. Dis. PD JAN PY 2012 VL 10 IS 1 BP 32 EP 42 DI 10.1016/j.tmaid.2011.12.003 PG 11 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 913LL UT WOS:000301879300004 PM 22245113 ER PT J AU Kim, C Chavez, P Pierce, A Murray, A Sander, M Kenyon, C Sharangpani, R Abernathy, E Icenogle, J Kutty, PK Redd, SB Gallagher, K Neatherlin, J Marienau, K AF Kim, Curi Chavez, Pollyanna Pierce, Abbi Murray, Andrew Sander, Molly Kenyon, Cynthia Sharangpani, Ruta Abernathy, Emily Icenogle, Joseph Kutty, Preeta K. Redd, Susan B. Gallagher, Kathleen Neatherlin, John Marienau, Karen TI Rubella contact tracing associated with air travel SO TRAVEL MEDICINE AND INFECTIOUS DISEASE LA English DT Article DE Rubella; Contact tracing; Travel; Aircraft AB This report reviews U.S. guidelines for the identification of persons exposed to rubella during air travel. In response to an individual with rubella who traveled on multiple flights, CDC conducted an airline contact investigation that was expanded beyond customary protocol to assess if current operating procedures are adequate. Of 250 potentially exposed airline passengers, 215 (86%) were contacted and none developed a rubella-like rash, arguing against the need to notify passengers beyond the standard protocol in most cases. Published by Elsevier Ltd. C1 [Kim, Curi; Neatherlin, John; Marienau, Karen] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Global Migrat & Quarantine, Atlanta, GA 30333 USA. [Chavez, Pollyanna] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Div Adult & Community Hlth, Atlanta, GA 30333 USA. [Pierce, Abbi; Sander, Molly] N Dakota Dept Hlth, Med Serv Sect, Div Dis Control, Bismarck, ND USA. [Murray, Andrew; Kenyon, Cynthia] Minnesota Dept Hlth, Infect Dis Epidemiol Prevent & Control Div, Immunizat TB & Int Hlth Sect, St Paul, MN USA. [Sharangpani, Ruta] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA. [Abernathy, Emily; Icenogle, Joseph; Kutty, Preeta K.; Redd, Susan B.; Gallagher, Kathleen] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Atlanta, GA 30333 USA. RP Kim, C (reprint author), Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Global Migrat & Quarantine, 1600 Clifton Rd,Bldg 20,MS C01, Atlanta, GA 30333 USA. EM ckim@cdc.gov NR 8 TC 3 Z9 3 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1477-8939 J9 TRAVEL MED INFECT DI JI Travel Med. Infect. Dis. PD JAN PY 2012 VL 10 IS 1 BP 48 EP 51 DI 10.1016/j.tmaid.2011.11.003 PG 4 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 913LL UT WOS:000301879300006 PM 22212199 ER PT J AU LaGrange, RD Abramowitz, S Koenig, LJ Barnes, W Conner, L Moschel, D AF LaGrange, R. D. Abramowitz, S. Koenig, L. J. Barnes, W. Conner, L. Moschel, D. TI Participant satisfaction with group and individual components of Adolescent Impact: a secondary prevention intervention for HIV-positive youth SO AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV LA English DT Article DE HIV; youth; adolescents; satisfaction; intervention ID HIGH-RISK SEX; CLIENT SATISFACTION; YOUNG-PEOPLE; BISEXUAL MEN; GAY AB Adolescent Impact, a developmentally targeted behavioral intervention aimed at decreasing risk behaviors and promoting health care adherence, was delivered to 83 HIV-infected youth, aged 13-21 years, receiving care in five urban HIV centers. Participants completed a patient satisfaction survey following the 12 part intervention consisting of seven groups and five individual sessions. A feedback questionnaire was also completed during each group session to gain more insight on participant experiences. Several indicators suggested high levels of satisfaction. First, overall attendance was relatively high. Second, participants rated their subjective experience and group content favorably. No differences in satisfaction ratings emerged between perinatally infected adolescents and those who acquired HIV through risk behaviors. However, differences emerged regarding perceived intervention utility and content-specific preferences. Findings suggest that Adolescent Impact participants were satisfied with the intervention and that a heterogeneous group of HIV-infected youth could be advantageously integrated into the same secondary prevention program. C1 [LaGrange, R. D.; Barnes, W.; Conner, L.] Childrens Natl Med Ctr, Washington, DC 20010 USA. [Abramowitz, S.; Moschel, D.] NYU, Dept Pediat, Med Ctr, New York, NY 10016 USA. [Koenig, L. J.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. RP LaGrange, RD (reprint author), Childrens Natl Med Ctr, Washington, DC 20010 USA. EM rlagrang@cnmc.org FU PHS HHS [U64CCU219448, U64CCU319459, U64CCU319455] NR 19 TC 3 Z9 3 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0954-0121 J9 AIDS CARE JI Aids Care-Psychol. Socio-Med. Asp. Aids-Hiv PY 2012 VL 24 IS 1 BP 119 EP 128 DI 10.1080/09540121.2011.592817 PG 10 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychology, Multidisciplinary; Respiratory System; Social Sciences, Biomedical SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychology; Respiratory System; Biomedical Social Sciences GA 908ZK UT WOS:000301531400015 PM 21854350 ER PT J AU Storm, JE Mazor, KA Aldous, KM Blount, BC Brodie, SE Serle, JB AF Storm, Jan E. Mazor, Kimberly A. Aldous, Kenneth M. Blount, Benjamin C. Brodie, Scott E. Serle, Janet B. TI Response to "Comment on 'Visual Contrast Sensitivity in Children Exposed to Tetrachloroethylene' by Storm et al" SO ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH LA English DT Letter ID ORGANIC-SOLVENTS C1 [Storm, Jan E.; Mazor, Kimberly A.] New York State Dept Hlth, Ctr Environm Hlth, Troy, NY USA. [Aldous, Kenneth M.] New York State Dept Hlth, Wadsworth Ctr, Albany, NY USA. [Blount, Benjamin C.] US Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. [Brodie, Scott E.; Serle, Janet B.] Mt Sinai Sch Med, Dept Opthalmol, New York, NY USA. RP Storm, JE (reprint author), NYS Ctr Environm Hlth, 547 River St, Troy, NY 12180 USA. EM jes19@health.state.ny.us NR 9 TC 0 Z9 0 U1 0 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1933-8244 J9 ARCH ENVIRON OCCUP H JI Arch. Environ. Occup. Health PY 2012 VL 67 IS 1 BP 53 EP 55 DI 10.1080/19338244.2012.645396 PG 3 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 911OR UT WOS:000301728500010 ER PT J AU Prosser, LA Grosse, SD Wittenberg, E AF Prosser, Lisa A. Grosse, Scott D. Wittenberg, Eve TI Health Utility Elicitation Is There Still a Role for Direct Methods? SO PHARMACOECONOMICS LA English DT Editorial Material ID QUALITY-OF-LIFE; COST-UTILITY; SIGNIFICANT OTHERS; CONJOINT-ANALYSIS; CAREGIVERS; CHILDREN; ISSUES; FAMILY; STATES C1 [Prosser, Lisa A.] Univ Michigan, Dept Pediat & Communicable Dis, Child Hlth Evaluat & Res Unit, Ann Arbor, MI 48109 USA. [Grosse, Scott D.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Wittenberg, Eve] Harvard Univ, Sch Publ Hlth, Ctr Hlth Decis Sci, Boston, MA 02115 USA. RP Prosser, LA (reprint author), Univ Michigan Hlth Syst, Div Gen Pediat, Child Hlth Evaluat & Res Unit, 300 N Ingalls St,Room 6E14,SPC 5456, Ann Arbor, MI 48109 USA. EM lisapros@med.umich.edu NR 31 TC 11 Z9 11 U1 1 U2 3 PU ADIS INT LTD PI AUCKLAND PA 41 CENTORIAN DR, PRIVATE BAG 65901, MAIRANGI BAY, AUCKLAND 1311, NEW ZEALAND SN 1170-7690 J9 PHARMACOECONOMICS JI Pharmacoeconomics PY 2012 VL 30 IS 2 BP 83 EP 86 PG 4 WC Economics; Health Care Sciences & Services; Health Policy & Services; Pharmacology & Pharmacy SC Business & Economics; Health Care Sciences & Services; Pharmacology & Pharmacy GA 906CZ UT WOS:000301323800001 PM 22185185 ER PT J AU Coker, AL Smith, PH Whitaker, DJ Le, B Crawford, TN Flerx, VC AF Coker, Ann L. Smith, Paige H. Whitaker, Daniel J. Le, Brenda Crawford, Timothy N. Flerx, Vicki C. TI Effect of an In-Clinic IPV Advocate Intervention to Increase Help Seeking, Reduce Violence, and Improve Well-Being SO VIOLENCE AGAINST WOMEN LA English DT Article DE abuse; depression; evaluation; health care; intervention; women ID INTIMATE PARTNER VIOLENCE; RANDOMIZED-CONTROLLED-TRIAL; HEALTH CONSEQUENCES; ABUSED WOMEN; CARE; PREGNANCY; SAFETY; FAMILY AB This quasi-experimental study investigated the efficacy of clinic-based advocacy for intimate partner violence (IPV) to increase help seeking, reduce violence, and improve women's well-being. Eligible and consenting women attending one of six selected clinics in the rural Southern United States were assessed for IPV. Consenting women disclosing IPV were offered either an in-clinic advocate intervention or usual care, depending on the clinic they attended and were followed for up to 24 months. Over follow-up time both IPV scores and depressive symptoms trended toward greater decline among women in the advocate intervention clinics relative to the usual care (business card referral only). C1 [Coker, Ann L.] Univ Kentucky, Sch Med, Dept Obstet & Gynecol, Coll Med, Lexington, KY 40536 USA. [Smith, Paige H.] Univ N Carolina, Greensboro, NC 27412 USA. [Whitaker, Daniel J.] Georgia State Univ, Inst Publ Hlth, Atlanta, GA 30303 USA. [Le, Brenda] Ctr Dis Control & Prevent, Atlanta, GA USA. [Flerx, Vicki C.] Clemson Univ, Clemson, SC USA. [Coker, Ann L.] Univ Kentucky, Dept Epidemiol, Coll Publ Hlth, Lexington, KY 40536 USA. RP Coker, AL (reprint author), Univ Kentucky, Sch Med, Dept Obstet & Gynecol, Coll Med, 800 Rose St,C-371, Lexington, KY 40536 USA. EM ann.coker@uky.edu FU PHS HHS [US4CCU419014] NR 31 TC 15 Z9 15 U1 5 U2 16 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1077-8012 J9 VIOLENCE AGAINST WOM JI Violence Against Women PD JAN PY 2012 VL 18 IS 1 BP 118 EP 131 DI 10.1177/1077801212437908 PG 14 WC Women's Studies SC Women's Studies GA 906OJ UT WOS:000301355300008 PM 22411302 ER PT J AU Strine, TW Beck, L Bolen, J Okoro, C Li, CY AF Strine, Tara W. Beck, Laurie Bolen, Julie Okoro, Catherine Li, Chaoyang TI Potential Moderating Role of Seat Belt Law on the Relationship Between Seat Belt Use and Adverse Health Behavior SO AMERICAN JOURNAL OF HEALTH BEHAVIOR LA English DT Article DE seat belts; injury prevention; adverse health behaviors; obesity; surveillance ID FACTOR SURVEILLANCE SYSTEM; RISK; EMERGENCY; ALCOHOL; INJURY; INTERVENTIONS; ENFORCEMENT; STATES; BRFSS AB Objective: To determine the potential moderating effect of seat belt law on seat belt compliance among persons who engage in adverse health behaviors. Methods: Self-reported use of seat belts and adverse health behaviors in a 2008 US state-based population survey. Results: Seat belt law moderates the use of seat belts among males and females who smoked, males who were physically inactive, and males and females who engaged in multiple risk behaviors. Conclusion: There is a need to supplement legislative interventions with more focused behavioral approaches to further increase seat belt compliance among persons who engage in adverse risk behaviors. C1 [Strine, Tara W.; Okoro, Catherine; Li, Chaoyang] Ctr Dis Control & Prevent, Off Surveillance Epidemiol & Lab Serv, Publ Hlth Surveillance Program Off, Div Behav Surveillance, Atlanta, GA 30333 USA. [Beck, Laurie] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Div Unintent Injury Prevent, Motor Vehicle Injury Prevent Team, Chamblee, GA USA. [Bolen, Julie] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Off Noncommunicable Dis Injury & Environm Hlth, Atlanta, GA USA. RP Strine, TW (reprint author), Ctr Dis Control & Prevent, Off Surveillance Epidemiol & Lab Serv, Publ Hlth Surveillance Program Off, Div Behav Surveillance, Atlanta, GA 30333 USA. EM tws2@cdc.gov NR 39 TC 0 Z9 0 U1 0 U2 2 PU PNG PUBLICATIONS PI OAK RIDGE PA 2205-K OAK RIDGE RD, #115, OAK RIDGE, NC 27310 USA SN 1945-7359 J9 AM J HEALTH BEHAV JI Am. J. Health Behav. PY 2012 VL 36 IS 1 BP 44 EP 55 PG 12 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 909MJ UT WOS:000301568300005 PM 22251782 ER PT J AU Strine, TW Dube, SR Edwards, VJ Prehn, AW Rasmussen, S Wagenfeld, M Dhingra, S Croft, JB AF Strine, Tara W. Dube, Shanta R. Edwards, Valerie J. Prehn, Angela Witt Rasmussen, Sandra Wagenfeld, Morton Dhingra, Satvinder Croft, Janet B. TI Associations Between Adverse Childhood Experiences, Psychological Distress, and Adult Alcohol Problems SO AMERICAN JOURNAL OF HEALTH BEHAVIOR LA English DT Article DE alcohol abuse; mental illness; child abuse; child neglect ID SF-36 HEALTH SURVEY; NATIONAL-COMORBIDITY-SURVEY; SEXUAL-ABUSE; MENTAL-HEALTH; RISK-FACTORS; HOUSEHOLD DYSFUNCTION; RETROSPECTIVE REPORTS; ANXIETY DISORDERS; MAJOR DEPRESSION; SUBSTANCE USE AB Objective: To examine the mediating role of psychological distress on the relationship between adverse childhood experiences and adult alcohol problems by gender. Methods: Linear and logistic regression analyses were conducted on 7279 Kaiser-Permanente members, aged >18 years. Results: Psychological distress mediated significant proportions of alcohol problems associated with childhood emotional abuse and neglect, physical abuse and neglect, mental illness in the household, parental separation or divorce, sexual abuse, and household drug use among women and mental illness in the household, emotional neglect, physical abuse, household drug use, and sexual abuse among men. Conclusion: It may be important to identify early childhood trauma and adult psychological distress in programs that focus on reducing alcohol abuse. C1 [Strine, Tara W.; Dhingra, Satvinder] Ctr Dis Control & Prevent, Off Surveillance Epidemiol & Lab Serv, Publ Hlth Surveillance Program Off, Div Behav Surveillance, Atlanta, GA 30333 USA. [Dube, Shanta R.] Ctr Dis Control & Prevent, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Edwards, Valerie J.; Croft, Janet B.] Ctr Dis Control & Prevent, Emerging Invest & Analyt Methods Branch, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Prehn, Angela Witt] Walden Univ, Coll Hlth Sci, Sch Hlth Sci, Minneapolis, MN USA. [Rasmussen, Sandra] Williamsville Wellness, Williamsville, NY USA. [Rasmussen, Sandra] Cambridge Coll, Mechanicsville, VA USA. [Wagenfeld, Morton] Walden Univ, Western Michigan Univ, Minneapolis, MN USA. [Dhingra, Satvinder] Northrop Grumman Corp, Los Angeles, CA USA. RP Strine, TW (reprint author), Ctr Dis Control & Prevent, Off Surveillance Epidemiol & Lab Serv, Publ Hlth Surveillance Program Off, Div Behav Surveillance, Atlanta, GA 30333 USA. EM tws2@cdc.gov NR 84 TC 30 Z9 31 U1 5 U2 32 PU PNG PUBLICATIONS PI OAK RIDGE PA 2205-K OAK RIDGE RD, #115, OAK RIDGE, NC 27310 USA SN 1945-7359 J9 AM J HEALTH BEHAV JI Am. J. Health Behav. PY 2012 VL 36 IS 3 BP 408 EP 423 DI 10.5993/AJHB.36.3.11 PG 16 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 909MO UT WOS:000301568900011 PM 22370441 ER PT J AU Welcome, DE Dong, RG Xu, XSY Warren, C McDowell, TW AF Welcome, Daniel E. Dong, Ren G. Xu, Xueyan S. Warren, Christopher McDowell, Thomas W. TI An evaluation of the proposed revision of the anti-vibration glove test method defined in ISO 10819 (1996) SO INTERNATIONAL JOURNAL OF INDUSTRIAL ERGONOMICS LA English DT Article DE Anti-vibration glove; Glove test; Hand-arm vibration; Hand-transmitted vibration ID HAND-ARM SYSTEM; TRANSMISSIBILITY; PERFORMANCE; PALM AB To improve the reliability of the anti-vibration (AV) glove test defined in the current standard, a revised version of the standard has been proposed. However, the revised method has not been fully tested and sufficiently evaluated, and it is unknown whether it is practically feasible and convenient to implement the standard. To help achieve the objective of the revision, the specific aims of this study are to examine the rationale behind the major revisions of the standard and to evaluate the major technical aspects of the revised method through an experiment. Five human subjects participated in the experiment for the evaluation. Fifteen gloves with anti-vibration features were used in the experiment. To help evaluate the AV glove criteria, the effects of the glove on the grip strength were also examined. While this study failed to realize the constant-velocity spectrum proposed in the original revision, the glove vibration transmissibility values measured with a new spectrum proposed in the current study were very similar to those measured with the M and H spectra defined in the current standard, which suggests the new spectrum can greatly simplify the test without changing the original test results, and it should be adopted in the further revision of the standard. The results of this study also strongly support the proposed major revisions in the instrumentation and test procedures. Coincidently, the glove that reduced the grip strength the least was also the one that reduced the most vibration, which suggests that the negative and positive effects of the glove can be balanced in its design. While the subject is identified as a major influencing factor, this study proposed a novel approach - the use of a reference glove in the test to minimize the inter-subject and inter-laboratory variations. Based on the results of this study, some other further revisions in the test procedures, evaluation methods, and AV glove criteria were also proposed and discussed. Relevance to industry: Anti-vibration gloves have been used as an alternative approach to reduce hand-transmitted vibration exposure. A standard is required to conduct a reliable screening test to help select appropriate anti-vibration gloves. This study can significantly help improve the current standard on the test. The results of this study can also be directly used to help select appropriate AV gloves. Published by Elsevier B.V. C1 [Dong, Ren G.] NIOSH, ECTB, HELD, CDC, Morgantown, WV 26505 USA. RP Dong, RG (reprint author), NIOSH, ECTB, HELD, CDC, 1095 Willowdale Rd,MS L-2027, Morgantown, WV 26505 USA. EM rkd6@cdc.gov OI McDowell, Thomas/0000-0002-2416-2210 FU US Navy Clothing and Textile Research Facility, Natick FX This study is partially sponsored by US Navy Clothing and Textile Research Facility, Natick, MA 01760. Special thanks to Ms. S. Krantz for her collaboration. Disclaimers: The content of this publication does not necessarily reflect the views or policies of the National Institute for Occupational Safety and Health (NIOSH), nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. NR 28 TC 11 Z9 12 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-8141 J9 INT J IND ERGONOM JI Int. J. Ind. Ergon. PD JAN PY 2012 VL 42 IS 1 BP 143 EP 155 DI 10.1016/j.ergon.2011.09.003 PG 13 WC Engineering, Industrial; Ergonomics SC Engineering GA 904RK UT WOS:000301215400018 ER PT J AU Groenewold, M Baron, S Tak, S Allred, N AF Groenewold, Matthew Baron, Sherry Tak, SangWoo Allred, Norma TI Influenza Vaccination Coverage Among US Nursing Home Nursing Assistants: The Role of Working Conditions SO JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION LA English DT Article DE Nursing assistants; nursing homes; organizational climate; health care personnel; influenza vaccination ID HEALTH-CARE WORKERS; LONG-TERM-CARE; RANDOMIZED CONTROLLED-TRIAL; UNITED-STATES; MANDATORY VACCINATION; IMMUNIZATION RATES; SAFETY CLIMATE; RESIDENTS; MORTALITY; FACILITIES AB Objectives: To estimate influenza vaccination coverage among nursing assistants (NAs) working in US nursing homes, and to identify demographic and occupational predictors of vaccination status among NAs. Design, setting, and participants: Cross-sectional analysis of data on 2873 NAs from the 2004 National Nursing Assistant Survey. Multivariable-adjusted vaccination coverage (prevalence) ratios for demographic and occupational characteristics were calculated using Poisson regression. Measurements: Outcome variable was NAs' influenza vaccination status, yes or no, based on the question, "During the past 12 months, did you receive a flu shot?" Results: Coverage for all NAs working in US nursing homes was estimated to be 37.1%. NAs 45 or older were more likely to be vaccinated than younger NAs (prevalence ratio [PR] 1.23, 95% confidence interval [CI]: 1.07-1.41). Significant negative associations with vaccination status were found for NAs who were non-Hispanic blacks (PR 0.82, 95% CI: 0.70-0.97), disagreed that they were respected/rewarded for their work (PR 0.85, 95% CI: 0.71-1.00), worked at for-profit facilities (PR 0.83, 95% CI: 0.72-0.95), and reported receiving fewer than 7 of 15 nonwage job benefits (PR 0.77, 95% CI: 0.67-0.90). Conclusion: Influenza coverage among nursing home NAs appears to be similar to nationally reported coverage estimates among health care providers in the United States in general. In addition to individual characteristics, occupational characteristics reflective of working conditions are associated with vaccination status among NAs, suggesting that further research into these types of associations may be useful in identifying which institutions may benefit from outreach efforts and types of interventions to increase vaccination coverage. Published by Elsevier Inc. on behalf of the American Medical Directors Association, Inc. C1 [Groenewold, Matthew; Baron, Sherry; Tak, SangWoo] NIOSH, Ctr Dis Control & Prevent, Alice Hamilton Lab, Cincinnati, OH 45226 USA. [Allred, Norma] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Groenewold, M (reprint author), NIOSH, Ctr Dis Control & Prevent, Alice Hamilton Lab, 4676 Columbia Pkwy,MS R-17, Cincinnati, OH 45226 USA. EM gyr5@cdc.gov NR 58 TC 2 Z9 2 U1 0 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1525-8610 J9 J AM MED DIR ASSOC JI J. Am. Med. Dir. Assoc. PD JAN PY 2012 VL 13 IS 1 AR 85.e17 DI 10.1016/j.jamda.2011.02.008 PG 7 WC Geriatrics & Gerontology SC Geriatrics & Gerontology GA 898HT UT WOS:000300733100035 PM 22208764 ER PT J AU Little, AR Miller, DB Li, S Kashon, ML O'Callaghan, JP AF Little, A. R. Miller, D. B. Li, S. Kashon, M. L. O'Callaghan, J. P. TI Trimethyltin-induced neurotoxicity: Gene expression pathway analysis, q-RT-PCR and immunoblotting reveal early effects associated with hippocampal damage and gliosis SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Article DE Neurotoxicity; Trimethyltin; Neuroinflammation; Ubiquitin-proteosome; Microarray; Neurodegeneration ID FIBRILLARY ACIDIC PROTEIN; PERIPHERAL BENZODIAZEPINE-RECEPTOR; INDUCED NEURONAL DAMAGE; CLASS-II EXPRESSION; RAT-BRAIN; REACTIVE ASTROCYTES; MESSENGER-RNA; ENHANCED EXPRESSION; GLIOTYPIC PROTEINS; NERVOUS-SYSTEM AB Damage to the CNS results in a complex series of molecular and cellular changes involving the affected targets and the ensuing glial reaction. The initial gene expression events that underlie these cellular responses may serve as early biomarkers of neurotoxicity. Here, we examined gene expression profiles during the initial phase of hippocampal damage resulting from systemic exposure of rats to the organometallic neurotoxicant, trimethyltin (TMT, 8.0 mg/kg, i.p.). Using TMT as a neurodegeneration tool confers several advantages for evaluating molecular events associated with neural damage: 1) regional and cellular targets and time course of damage are known, 2) the blood-brain barrier is not compromised, which limits the contribution of blood-borne factors, e.g. immune, to neural injury responses and 3) known protein and mRNA signatures of TMT-induced neurotoxicity can be used as positive controls to validate novel expression events associated with exposure to this neurotoxicant. Using Affymetrix Gene Chip (R) to assess gene expression after TWIT, combined with Ingenuity Pathway Analysis (R), we observed changes consistent for genes known to be affected in hippocampus, while corresponding changes were not detected in cerebellum, a non-target region. In agreement with previous observations, limited changes in expression of inflammation-related genes were observed. Correlated expression profiles were found after exposure to TMT, including changes in gene ontologies associated with neurological disease, cellular assembly and maintenance, as well as signaling pathways associated with cellular stress, energy metabolism and glial activation. Selected gene changes were confirmed from each category by q-RT-PCR and immunoblot analysis. The canonical relationships identified implicate molecular pathways and processes relevant to detection of early stages of hippocampal damage in the TMT model. These observations provide new insight into early events associated with neuronal degeneration and associated glial activation that may serve as the basis for discovery and development of biomarkers of neurotoxicity. (C) 2011 Published by Elsevier Inc. C1 [Little, A. R.; Miller, D. B.; Li, S.; Kashon, M. L.; O'Callaghan, J. P.] NIOSH, Ctr Dis Control & Prevent, Hlth Effects Res Lab, Mol Neurotoxicol Lab, Morgantown, WV 26505 USA. RP Little, AR (reprint author), NIOSH, Ctr Dis Control & Prevent, Hlth Effects Res Lab, Mol Neurotoxicol Lab, 1095 Willowdale Rd, Morgantown, WV 26505 USA. EM jdo5@cdc.gov RI Miller, Diane/O-2927-2013; O'Callaghan, James/O-2958-2013; Little, A/O-6191-2014 OI Little, A/0000-0001-6831-0177 NR 58 TC 12 Z9 12 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD JAN-FEB PY 2012 VL 34 IS 1 BP 72 EP 82 DI 10.1016/j.ntt.2011.09.012 PG 11 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA 902KN UT WOS:000301037100009 PM 22108043 ER PT J AU Cannon, MJ Dominique, Y O'Leary, LA Sniezek, JE Floyd, RL AF Cannon, Michael J. Dominique, Yvette O'Leary, Leslie A. Sniezek, Joseph E. Floyd, R. Louise TI Characteristics and behaviors of mothers who have a child with fetal alcohol syndrome SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Article DE Fetal alcohol syndrome; Surveillance; Risk factors ID WESTERN CAPE PROVINCE; MATERNAL RISK-FACTORS; SOUTH-AFRICA; SPECTRUM DISORDERS; PREVENTING ALCOHOL; NORTHERN PLAINS; BIRTH MOTHERS; SYNDROME FAS; PREVALENCE; WOMEN AB Fetal alcohol syndrome (FAS) is a leading cause of birth defects and developmental disabilities. The objective of this study was to identify the characteristics and behaviors of mothers of children with FAS in the United States using population-based data from the FAS Surveillance Network (FASSNet). FASSNet used a multiple source methodology that identified FAS cases through passive reporting and active review of records from hospitals, specialty clinics, private physicians, early intervention programs, Medicaid, birth certificates and other vital records, birth defects surveillance programs, and hospital discharge data. The surveillance included children born during January 1, 1995-December 31, 1997. In the four states included in our analysis - Arizona, New York, Alaska, and Colorado - there were 257 confirmed cases and 96 probable cases for a total of 353 FAS cases. Compared to all mothers in the states where surveillance occurred, mothers of children with FAS were significantly more likely to be older, American Indians/Alaska Natives, Black, not Hispanic, unmarried, unemployed, and without prenatal care, to smoke during pregnancy, to have a lower educational level, and to have more live born children. A significant proportion of mothers (9-29%) had another child with suspected alcohol effects. Compared to all US mothers, they were also significantly more likely to be on public assistance, to be on Medicaid at their child's birth, to have received treatment for alcohol abuse, to have confirmed alcoholism, to have used marijuana or cocaine during pregnancy, to have their baby screen positive for alcohol or drugs at birth, to have had an induced abortion, to have had a history of mental illness, to have been involved in binge drinking during pregnancy, and to have drunk heavily (7 days/week) during pregnancy. These findings suggest that it is possible to identify women who are at high risk of having a child with FAS and target these women for interventions. Published by Elsevier Inc. C1 [Cannon, Michael J.; Dominique, Yvette; O'Leary, Leslie A.; Sniezek, Joseph E.; Floyd, R. Louise] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. RP Cannon, MJ (reprint author), 1600 Clifton Rd,Mailstop E-86, Atlanta, GA 30333 USA. EM mcannon@cdc.gov RI Cannon, Michael/E-5894-2011 OI Cannon, Michael/0000-0001-5776-5010 NR 32 TC 9 Z9 9 U1 5 U2 34 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD JAN-FEB PY 2012 VL 34 IS 1 BP 90 EP 95 DI 10.1016/j.ntt.2011.09.010 PG 6 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA 902KN UT WOS:000301037100011 PM 22001355 ER PT J AU Croker, C Redelings, M Reporter, R Sorvillo, F Mascola, L Wilkins, P AF Croker, Curtis Redelings, Matthew Reporter, Roshan Sorvillo, Frank Mascola, Laurene Wilkins, Patricia TI The Impact of Neurocysticercosis in California: A Review of Hospitalized Cases SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Review ID LOS-ANGELES-COUNTY; UNITED-STATES; CYSTICERCOSIS; DEATHS AB To assess the burden of neurocysticercosis (NCC) in California we examined statewide hospital discharge data for 2009. There were 304 cases hospitalized with NCC identified (incidence = 0.8 per 100,000). Cases were mostly Latino (84.9%), slightly more likely to be male than female (men 57.6%, women 42.4%) with an average age of 43.5 years. A majority of cases were hospitalized in Southern California (72.1%) and many were hospitalized in Los Angeles County (44.7%). Men were more likely than women to have severe disease including hydrocephalus (29.7% vs. 18.6%, p = 0.027), resulting in longer hospitalizations (> 4 days, 48.0% vs. 32.6%, p = 0.007) that were more costly (charge >$40 thousand men = 46.9% vs. woman = 4.1%, p = 0.026). Six deaths were recorded (2.0%). The total of NCC-related hospital charges exceeded $17 million; estimated hospital costs exceeded $5 million. Neurocysticercosis causes appreciable disease and exacts a considerable economic burden in California. C1 [Croker, Curtis; Reporter, Roshan; Mascola, Laurene] Cty Los Angeles Dept Publ Hlth, Acute Communicable Dis Control Program, Los Angeles, CA USA. [Redelings, Matthew; Sorvillo, Frank] Cty Los Angeles Dept Publ Hlth, Data Collect & Anal Program, Los Angeles, CA USA. [Wilkins, Patricia] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA USA. RP Croker, C (reprint author), Cty Los Angeles Dept Publ Hlth, Acute Communicable Dis Control Program, Los Angeles, CA USA. EM ccroker@ph.lacounty.gov FU County of Los Angeles Department of Public Health FX All financial support for this project has been provided by the County of Los Angeles Department of Public Health. There were no grant funds used to support this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 12 TC 18 Z9 18 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD JAN PY 2012 VL 6 IS 1 AR e1480 DI 10.1371/journal.pntd.0001480 PG 6 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 894GW UT WOS:000300416100025 PM 22292097 ER PT J AU Gass, K de Rochars, MVEB Boakye, D Bradley, M Fischer, PU Gyapong, J Itoh, M Ituaso-Conway, N Joseph, H Kyelem, D Laney, SJ Legrand, AM Liyanage, TS Melrose, W Mohammed, K Pilotte, N Ottesen, EA Plichart, C Ramaiah, K Rao, RU Talbot, J Weil, GJ Williams, SA Won, KY Lammie, P AF Gass, Katherine de Rochars, Madsen V. E. Beau Boakye, Daniel Bradley, Mark Fischer, Peter U. Gyapong, John Itoh, Makoto Ituaso-Conway, Nese Joseph, Hayley Kyelem, Dominique Laney, Sandra J. Legrand, Anne-Marie Liyanage, Tilaka S. Melrose, Wayne Mohammed, Khalfan Pilotte, Nils Ottesen, Eric A. Plichart, Catherine Ramaiah, Kapa Rao, Ramakrishna U. Talbot, Jeffrey Weil, Gary J. Williams, Steven A. Won, Kimberly Y. Lammie, Patrick TI A Multicenter Evaluation of Diagnostic Tools to Define Endpoints for Programs to Eliminate Bancroftian Filariasis SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID LYMPHATIC FILARIASIS; FILTER-PAPER; CIRCULATING ANTIGEN; BLOOD; INFECTION; SAMPLES; ASSAY AB Successful mass drug administration (MDA) campaigns have brought several countries near the point of Lymphatic Filariasis (LF) elimination. A diagnostic tool is needed to determine when the prevalence levels have decreased to a point that MDA campaigns can be discontinued without the threat of recrudescence. A six-country study was conducted assessing the performance of seven diagnostic tests, including tests for microfilariae (blood smear, PCR), parasite antigen (ICT, Og4C3) and antifilarial antibody (Bm14, PanLF, Urine SXP). One community survey and one school survey were performed in each country. A total of 8,513 people from the six countries participated in the study, 6,443 through community surveys and 2,070 through school surveys. Specimens from these participants were used to conduct 49,585 diagnostic tests. Each test was seen to have both positive and negative attributes, but overall, the ICT test was found to be 76% sensitive at detecting microfilaremia and 93% specific at identifying individuals negative for both microfilariae and antifilarial antibody; the Og4C3 test was 87% sensitive and 95% specific. We conclude, however, that the ICT should be the primary tool recommended for decision-making about stopping MDAs. As a point-of-care diagnostic, the ICT is relatively inexpensive, requires no laboratory equipment, has satisfactory sensitivity and specificity and can be processed in 10 minutes-qualities consistent with programmatic use. Og4C3 provides a satisfactory laboratory-based diagnostic alternative. C1 [Gass, Katherine; Kyelem, Dominique; Ottesen, Eric A.; Talbot, Jeffrey] Task Force Global Hlth, Lymphat Filariasis Support Ctr, Decatur, GA USA. [de Rochars, Madsen V. E. Beau] Hop Ste Croix, Leogane, Haiti. [Boakye, Daniel] Univ Ghana, Noguchi Mem Inst Med Res, Legon, Ghana. [Bradley, Mark] GlaxoSmithKline Inc, Global Community Partnerships, London, England. [Fischer, Peter U.; Rao, Ramakrishna U.; Weil, Gary J.] Washington Univ, Sch Med, St Louis, MO USA. [Gyapong, John] Ghana Hlth Serv, Div Res & Dev, Accra, Ghana. [Itoh, Makoto] Aichi Med Univ, Sch Med, Dept Parasitol, Nagakute, Aichi 48011, Japan. [Ituaso-Conway, Nese] Minist Hlth, Natl Program Eliminat Lymphat Filariasis, Funafuti, Tuvalu. [Joseph, Hayley; Melrose, Wayne] James Cook Univ, Lymphat Filariasis Support Ctr, Sch Publ Hlth Trop Med & Rehabil Sci, Townsville, Qld 4811, Australia. [Laney, Sandra J.; Pilotte, Nils; Williams, Steven A.] Smith Coll, Dept Biol Sci, Northampton, MA 01063 USA. [Legrand, Anne-Marie; Plichart, Catherine] Inst Louis Malarde, Papeete, Tahiti, Fr Polynesia. [Liyanage, Tilaka S.] Sri Lanka Minist Hlth & Nutr, Colombo, Sri Lanka. [Mohammed, Khalfan] Minist Hlth, Neglected Trop Dis Control Program, Zanzibar, Tanzania. [Ramaiah, Kapa] Indian Council Med Res, Vector Control Res Ctr, Pondicherry, India. [Won, Kimberly Y.; Lammie, Patrick] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA USA. RP Gass, K (reprint author), Task Force Global Hlth, Lymphat Filariasis Support Ctr, Decatur, GA USA. EM pjl1@cdc.gov RI Research ID, CTBCC /O-3564-2014 FU Bill and Melinda Gates Foundation FX This research was funded by the Bill and Melinda Gates Foundation. The Bill and Melinda Gates Foundation awarded the Global Programme to Eliminate Lymphatic Filariasis a grant entitled 'Resolving the critical challenges now facing the GPELF' for operational research. The grant is available at: http://www.filariasis.org/gates_foundation_grant.html. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 18 TC 41 Z9 42 U1 1 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1935-2727 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD JAN PY 2012 VL 6 IS 1 AR e1479 DI 10.1371/journal.pntd.0001479 PG 12 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 894GW UT WOS:000300416100024 PM 22272369 ER PT J AU Hunter, GC Borrini-Mayori, K Juarez, JA Neyra, RC Verastegui, MR Chavez, FSM del Carpio, JGC Benzaquen, EC Naquira, C Gilman, RH Bern, C Levy, MZ AF Hunter, Gabrielle C. Borrini-Mayori, Katty Ancca Juarez, Jenny Castillo Neyra, Ricardo Verastegui, Manuela R. Malaga Chavez, Fernando S. Geny Cornejo del Carpio, Juan Cordova Benzaquen, Eleazar Naquira, Cesar Gilman, Robert H. Bern, Caryn Levy, Michael Z. TI A Field Trial of Alternative Targeted Screening Strategies for Chagas Disease in Arequipa, Peru SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID TRYPANOSOMA-CRUZI INFECTION; VECTOR CONTROL STRATEGIES; COST-EFFECTIVENESS; TRIATOMA-INFESTANS; LATIN-AMERICA; GRAN CHACO; TRANSMISSION; ARGENTINA; COMMUNITY; PATTERNS AB Background: Chagas disease is endemic in the rural areas of southern Peru and a growing urban problem in the regional capital of Arequipa, population similar to 860,000. It is unclear how to implement cost-effective screening programs across a large urban and periurban environment. Methods: We compared four alternative screening strategies in 18 periurban communities, testing individuals in houses with 1) infected vectors; 2) high vector densities; 3) low vector densities; and 4) no vectors. Vector data were obtained from routine Ministry of Health insecticide application campaigns. We performed ring case detection (radius of 15 m) around seropositive individuals, and collected data on costs of implementation for each strategy. Results: Infection was detected in 21 of 923 (2.28%) participants. Cases had lived more time on average in rural places than non-cases (7.20 years versus 3.31 years, respectively). Significant risk factors on univariate logistic regression for infection were age (OR 1.02; p = 0.041), time lived in a rural location (OR 1.04; p = 0.022), and time lived in an infested area (OR 1.04; p = 0.008). No multivariate model with these variables fit the data better than a simple model including only the time lived in an area with triatomine bugs. There was no significant difference in prevalence across the screening strategies; however a self-assessment of disease risk may have biased participation, inflating prevalence among residents of houses where no infestation was detected. Testing houses with infected-vectors was least expensive. Ring case detection yielded four secondary cases in only one community, possibly due to vector-borne transmission in this community, apparently absent in the others. Conclusions: Targeted screening for urban Chagas disease is promising in areas with ongoing vector-borne transmission; however, these pockets of epidemic transmission remain difficult to detect a priori. The flexibility to adapt to the epidemiology that emerges during screening is key to an efficient case detection intervention. In heterogeneous urban environments, self-assessments of risk and simple residence history questionnaires may be useful to identify those at highest risk for Chagas disease to guide diagnostic efforts. C1 [Hunter, Gabrielle C.; Gilman, Robert H.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA. [Borrini-Mayori, Katty; Ancca Juarez, Jenny; Castillo Neyra, Ricardo; Verastegui, Manuela R.; Naquira, Cesar] Univ Peruana Cayetano Heredia, Fac Ciencias & Filosofia, Lima, Peru. [Castillo Neyra, Ricardo] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. [Malaga Chavez, Fernando S.; Geny Cornejo del Carpio, Juan] Direcc Reg Minist Salud, Arequipa, Peru. [Cordova Benzaquen, Eleazar] Univ Nacl San Agusti, Dept Microbiol & Patol, Fac Med, Arequipa, Peru. [Bern, Caryn] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA. [Levy, Michael Z.] Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA. RP Hunter, GC (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA. EM mzlevy@mail.med.upenn.edu FU National Institutes of Health (NIH) [5K01 AI079162-02, 5K01 AI079162-03, NIH 3K01AI079162-02S1, NIH 3K01AI079162-03S1, NIH P50 AI074285-03, NIH P50 AI074285-04] FX Funding for this study came from National Institutes of Health (NIH) 5K01 AI079162-02 and 03, NIH 3K01AI079162-02S1 and 03S1, NIH P50 AI074285-03, and 04. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 42 TC 8 Z9 8 U1 4 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD JAN PY 2012 VL 6 IS 1 AR e1468 DI 10.1371/journal.pntd.0001468 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 894GW UT WOS:000300416100019 PM 22253939 ER PT J AU Lin, HE Tsai, WY Liu, IJ Li, PC Liao, MY Tsai, JJ Wu, YC Lai, CY Lu, CH Huang, JH Chang, GJ Wu, HC Wang, WK AF Lin, Hong-En Tsai, Wen-Yang Liu, I-Ju Li, Pi-Chun Liao, Mei-Ying Tsai, Jih-Jin Wu, Yi-Chieh Lai, Chih-Yun Lu, Chih-Hsuan Huang, Jyh-Hsiung Chang, Gwong-Jen Wu, Han-Chung Wang, Wei-Kung TI Analysis of Epitopes on Dengue Virus Envelope Protein Recognized by Monoclonal Antibodies and Polyclonal Human Sera by a High Throughput Assay SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID WEST-NILE-VIRUS; TICK-BORNE ENCEPHALITIS; LINKED IMMUNOSORBENT ASSAYS; DOMAIN-III; NEUTRALIZING ANTIBODIES; ANTIGENIC DETERMINANTS; IN-VITRO; GLYCOPROTEIN; INFECTION; FUSION AB Background: The envelope (E) protein of dengue virus (DENV) is the major target of neutralizing antibodies and vaccine development. While previous studies on domain III or domain I/II alone have reported several epitopes of monoclonal antibodies (mAbs) against DENV E protein, the possibility of interdomain epitopes and the relationship between epitopes and neutralizing potency remain largely unexplored. Methodology/Principal Findings: We developed a dot blot assay by using 67 alanine mutants of predicted surface-exposed E residues as a systematic approach to identify epitopes recognized by mAbs and polyclonal sera, and confirmed our findings using a capture-ELISA assay. Of the 12 mouse mAbs tested, three recognized a novel epitope involving residues (Q211, D215, P217) at the central interface of domain II, and three recognized residues at both domain III and the lateral ridge of domain II, suggesting a more frequent presence of interdomain epitopes than previously appreciated. Compared with mAbs generated by traditional protocols, the potent neutralizing mAbs generated by a new protocol recognized multiple residues in A strand or residues in C strand/CC9 loop of DENV2 and DENV1, and multiple residues in BC loop and residues in DE loop, EF loop/F strand or G strand of DENV1. The predominant epitopes of anti-E antibodies in polyclonal sera were found to include both fusion loop and non-fusion residues in the same or adjacent monomer. Conclusions/Significance: Our analyses have implications for epitope-specific diagnostics and epitope-based dengue vaccines. This high throughput method has tremendous application for mapping both intra and interdomain epitopes recognized by human mAbs and polyclonal sera, which would further our understanding of humoral immune responses to DENV at the epitope level. C1 [Lin, Hong-En; Lu, Chih-Hsuan; Wang, Wei-Kung] Natl Taiwan Univ, Inst Microbiol, Coll Med, Taipei 10764, Taiwan. [Tsai, Wen-Yang; Wu, Yi-Chieh; Lai, Chih-Yun; Wang, Wei-Kung] Univ Hawaii Manoa, Dept Trop Med Med Microbiol & Pharmacol, John A Burns Sch Med, Honolulu, HI 96822 USA. [Liu, I-Ju; Li, Pi-Chun; Liao, Mei-Ying; Wu, Han-Chung] Acad Sinica, Inst Cellular & Organism Biol, Taipei 115, Taiwan. [Tsai, Jih-Jin] Kaohsiung Med Univ Hosp, Trop Med Ctr, Kaohsiung, Taiwan. [Tsai, Jih-Jin] Kaohsiung Med Univ Hosp, Dept Internal Med, Kaohsiung, Taiwan. [Tsai, Jih-Jin] Kaohsiung Med Univ, Fac Med, Coll Med, Kaohsiung, Taiwan. [Huang, Jyh-Hsiung] Ctr Dis Control, Dept Hlth, Taipei, Taiwan. [Chang, Gwong-Jen] US Dept HHS, Div Vector Borne Dis, Ctr Dis Control & Prevent, Ft Collins, CO USA. RP Lin, HE (reprint author), Natl Taiwan Univ, Inst Microbiol, Coll Med, Taipei 10764, Taiwan. EM wangwk@hawaii.edu RI Wu, Han-Chung/B-1209-2011 OI Wu, Han-Chung/0000-0002-5185-1169 FU National Science Council Taiwan [NSC95-2320-B-002-084-MY3]; International Vaccine Institute/Pediatric Dengue Vaccine Initiative; JABSOM FX This work was supported in part by the National Science Council Taiwan (NSC95-2320-B-002-084-MY3), Cooperative Research Agreement by International Vaccine Institute/Pediatric Dengue Vaccine Initiative, and start-up fund from JABSOM. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 60 TC 32 Z9 32 U1 0 U2 11 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1935-2727 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD JAN PY 2012 VL 6 IS 1 AR e1447 DI 10.1371/journal.pntd.0001447 PG 12 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 894GW UT WOS:000300416100007 PM 22235356 ER PT J AU Warner, L Gallo, MF Macaluso, M AF Warner, Lee Gallo, Maria F. Macaluso, Maurizio TI Condom use around the globe: how can we fulfil the prevention potential of male condoms? SO SEXUAL HEALTH LA English DT Editorial Material ID HUMAN-IMMUNODEFICIENCY-VIRUS; SEXUALLY-TRANSMITTED INFECTIONS; LATEX CONDOM; VAGINAL INTERCOURSE; UNITED-STATES; CONTROLLED-TRIAL; DOUBLE-BLIND; RISK; HIV; TRANSMISSION C1 [Warner, Lee; Gallo, Maria F.] Ctr Dis Control & Prevent CDC, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, Atlanta, GA 30341 USA. [Macaluso, Maurizio] Cincinnati Childrens Hosp, Med Ctr, Cincinnati, OH 45229 USA. RP Warner, L (reprint author), Ctr Dis Control & Prevent CDC, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, Atlanta, GA 30341 USA. EM dlw7@cdc.gov RI Macaluso, Maurizio/J-2076-2015 OI Macaluso, Maurizio/0000-0002-2977-9690 NR 86 TC 12 Z9 12 U1 2 U2 12 PU CSIRO PUBLISHING PI COLLINGWOOD PA 150 OXFORD ST, PO BOX 1139, COLLINGWOOD, VICTORIA 3066, AUSTRALIA SN 1448-5028 J9 SEX HEALTH JI Sex Health PY 2012 VL 9 IS 1 BP 4 EP 9 DI 10.1071/SH11072 PG 6 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 903QZ UT WOS:000301135100003 PM 22348627 ER PT J AU Gallo, MF Kilbourne-Brook, M Coffey, PS AF Gallo, Maria F. Kilbourne-Brook, Maggie Coffey, Patricia S. TI A review of the effectiveness and acceptability of the female condom for dual protection SO SEXUAL HEALTH LA English DT Review DE FC1; FC2; Femidom; Reddy Condom; Woman's Condom ID SEXUALLY-TRANSMITTED-DISEASES; COMMUNITY INTERVENTION TRIAL; PATH WOMANS CONDOM; ANAL SEX; CONTRACEPTIVE EFFICACY; WOMENS EMPOWERMENT; BARRIER METHODS; PREVENTION; INTERCOURSE; SEMEN AB The female condom remains the sole female-initiated method of dual protection against unintended pregnancy and sexually transmissible infections (STIs), including HIV. We reviewed published data on the effectiveness and acceptability of the female condom for protection against pregnancy and infection. Overall, use of the female condom is low and several barriers hinder the wider adoption of the use of the method. Research on effectiveness has focussed on pregnancy, STIs and biological markers of semen exposure. Although the data available suggest that female condoms (or a mixture of female and male condoms) may provide similar degrees of protection against pregnancy and STIs as do latex male condoms alone, this conclusion has not been demonstrated and thus comparative research is urgently needed. C1 [Gallo, Maria F.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30333 USA. [Kilbourne-Brook, Maggie; Coffey, Patricia S.] PATH, Seattle, WA USA. RP Gallo, MF (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30333 USA. EM mgallo@cdc.gov RI Ghartouchent, malek/B-9088-2012 FU USAID FX Coffey and Kilbourne-Brook work for PATH, an international, non-profit, non-governmental organization whose mission is to improve the health of people around the world by advancing technologies, strengthening systems, and encouraging healthy behaviours (www.path.org). PATH designed and developed the Woman's Condom with support from USAID and other donors. In 2008, PATH licensed the Woman's Condom technology for commercialization to Shanghai Dahua Medical Apparatus Corporation. PATH has no financial or royalty interest in the Woman's Condom agreement with Dahua. NR 63 TC 18 Z9 20 U1 3 U2 9 PU CSIRO PUBLISHING PI COLLINGWOOD PA 150 OXFORD ST, PO BOX 1139, COLLINGWOOD, VICTORIA 3066, AUSTRALIA SN 1448-5028 J9 SEX HEALTH JI Sex Health PY 2012 VL 9 IS 1 BP 18 EP 26 DI 10.1071/SH11037 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 903QZ UT WOS:000301135100005 PM 22348629 ER PT J AU Ishida, K Arnold, M Stupp, P Kizito, P Ichwara, J AF Ishida, Kanako Arnold, Michael Stupp, Paul Kizito, Paul Ichwara, Jared TI Exploring the connections between HIV serostatus and individual, household, and community socioeconomic resources: Evidence from two population-based surveys in Kenya SO SOCIAL SCIENCE & MEDICINE LA English DT Article DE HIV; Socioeconomic status; Education; Wealth; Community-effects; Multi-level modeling; Kenya; Sub-saharan Africa; Gender ID SUB-SAHARAN AFRICA; HEALTH BEHAVIORS; SEXUAL-BEHAVIOR; INFECTION; RISK; TRANSMISSION; HIV/AIDS; WEALTH; INEQUALITIES; COUNTRIES AB The positive association between health and socioeconomic status (SES) is well documented. However, available empirical evidence on the SES gradients of HIV serostatus is mixed, and few studies have explored the effects of community SES indicators on individual's HIV risk. Using nationally representative data of women and men from the 2003 Demographic and Health Survey and the 2007 AIDS Indicator Survey from Kenya, we assessed the associations between HIV serostatus and SES as measured by educational attainment and household wealth at the individual/household and community levels. Additionally, we explored changes in these associations between 2003 and 2007. Results from bivariate and cohort analyses showed that during this period, HIV burden shifted from higher to lower SES subgroups at both the individual/household and community levels, particularly among women aged 15 -24 years. Results from multi-level logistic regression models showed that this shift was generally significant among women. In addition, communities' collective educational attainment, measured as the percentage of residents with some secondary schooling or higher, was a more significant predictor and protective factor for HIV risk than individual/household-level SES indicators for women in 2007 and men in both years. Our findings highlight the relevance of community-level SES to HIV dynamics in Kenya between 2003 and 2007. Published by Elsevier Ltd. C1 [Ishida, Kanako; Stupp, Paul] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA. [Arnold, Michael] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Kizito, Paul] Natl Coordinating Agcy Populat & Dev, Nairobi, Kenya. [Ichwara, Jared] Kenya Natl Bur Stat, Nairobi, Kenya. RP Ishida, K (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, 4770 Buford Hwy NE,MS K-23, Atlanta, GA 30341 USA. EM kishida@cdc.gov NR 30 TC 6 Z9 6 U1 1 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0277-9536 J9 SOC SCI MED JI Soc. Sci. Med. PD JAN PY 2012 VL 74 IS 2 BP 185 EP 195 DI 10.1016/j.socscimed.2011.10.019 PG 11 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA 899II UT WOS:000300809200011 PM 22169625 ER PT S AU Eisen, RJ Gage, KL AF Eisen, Rebecca J. Gage, Kenneth L. BE Berenbaum, MR TI Transmission of Flea-Borne Zoonotic Agents SO ANNUAL REVIEW OF ENTOMOLOGY, VOL 57 SE Annual Review of Entomology LA English DT Review; Book Chapter DE flea; vector-borne disease; plague; murine typhus; Rickettsia felis; Bartonella ID EARLY-PHASE TRANSMISSION; SOUTHWESTERN UNITED-STATES; CTENOCEPHALIDES-FELIS BOUCHE; PLAGUE-VECTOR EFFICIENCY; TAILED PRAIRIE DOGS; WEST NILE REGION; YERSINIA-PESTIS; MURINE TYPHUS; XENOPSYLLA-CHEOPIS; RICKETTSIA-FELIS AB Flea-borne zoonoses such as plague (Yersinia pestis) and murine typhus (Rickettsia typhi) caused significant numbers of human cases in the past and remain a public health concern. Other flea-borne human pathogens have emerged recently (e. g., Bartonella henselae, Rickettsia felis), and their mechanisms of transmission and impact on human health are not fully understood. Our review focuses on the ecology and epidemiology of the flea-borne bacterial zoonoses mentioned above with an emphasis on recent advancements in our understanding of how these organisms are transmitted by fleas, maintained in zoonotic cycles, and transmitted to humans. Emphasis is given to plague because of the considerable number of studies generated during the first decade of the twenty-first century that arose, in part, because of renewed interest in potential agents of bioterrorism, including Y. pestis. C1 [Eisen, Rebecca J.; Gage, Kenneth L.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA. RP Eisen, RJ (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA. EM dyn2@cdc.gov NR 129 TC 44 Z9 46 U1 5 U2 54 PU ANNUAL REVIEWS PI PALO ALTO PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA SN 0066-4170 BN 978-0-8243-0157-6 J9 ANNU REV ENTOMOL JI Annu. Rev. Entomol. PY 2012 VL 57 BP 61 EP 82 DI 10.1146/annurev-ento-120710-100717 PG 22 WC Entomology SC Entomology GA BYR10 UT WOS:000299834000005 PM 21888520 ER PT S AU Collins, WE AF Collins, William E. BE Berenbaum, MR TI Plasmodium knowlesi: A Malaria Parasite of Monkeys and Humans SO ANNUAL REVIEW OF ENTOMOLOGY, VOL 57 SE Annual Review of Entomology LA English DT Review; Book Chapter DE human malaria; mosquitoes; Anopheles leucosphyrus; Southeast Asia; Borneo ID ANOPHELES-BALABACENSIS-BALABACENSIS; INFECTED RHESUS-MONKEYS; SIMIAN-MALARIA; ERYTHROCYTE-MEMBRANE; MEROZOITE SURFACE; VARIANT ANTIGEN; MACACA-MULATTA; SPOROZOITE TRANSMISSION; LONG-TERM; VACCINATION AB Plasmodium knowlesi is a malaria parasite of monkeys of Southeast Asia that is transmitted by mosquitoes of the Anopheles leucosphyrus group. Humans are frequently infected with this parasite and misdiagnosed as being infected with Plasmodium malariae. The parasite was a major monkey animal model for developing antimalarial vaccines and investigations of the biology of parasite invasion. P. knowlesi is the first monkey malaria parasite genome to be sequenced and annotated. C1 Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30333 USA. RP Collins, WE (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30333 USA. EM wec1@cdc.gov NR 91 TC 23 Z9 25 U1 5 U2 15 PU ANNUAL REVIEWS PI PALO ALTO PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA SN 0066-4170 BN 978-0-8243-0157-6 J9 ANNU REV ENTOMOL JI Annu. Rev. Entomol. PY 2012 VL 57 BP 107 EP 121 DI 10.1146/annurev-ento-121510-133540 PG 15 WC Entomology SC Entomology GA BYR10 UT WOS:000299834000007 PM 22149265 ER PT J AU Barkhash, AV Perelygin, AA Babenko, VN Brinton, MA Voevoda, MI AF Barkhash, Andrey V. Perelygin, Andrey A. Babenko, Vladimir N. Brinton, Margo A. Voevoda, Mikhail I. TI Single nucleotide polymorphism in the promoter region of the CD209 gene is associated with human predisposition to severe forms of tick-borne encephalitis SO ANTIVIRAL RESEARCH LA English DT Article DE Tick-borne encephalitis (TBE); Human genetic predisposition; Dendritic cell-specific intercellular adhesion; molecule-3 (ICAM3)-grabbing non-integrin; (DC-SIGN); CD209 gene; Single nucleotide polymorphism (SNP) ID DENGUE HEMORRHAGIC-FEVER; DC-SIGN; DENDRITIC CELLS; VIRUS-INFECTION; DISEASE; TUBERCULOSIS; VARIANT; HIV AB Tick-borne encephalitis virus (TBEV) is a neurotropic, positive-sense RNA virus of the genus Flavivirus (family Flaviviridae) which can cause a variety of clinical manifestations in humans. Previously the severity and outcome of dengue fever and hepatitis C (diseases caused by viruses from the family Flaviviridae) were associated with the rs4804803 single nucleotide polymorphism (SNP) located in the promoter region of the human CD209 gene. This gene encodes dendritic cell-specific ICAM3-grabbing nonintegrin (DC-SIGN), a C-type lectin pathogen-recognition receptor expressed on the surface of dendritic cells and some types of macrophages. In the current study, a possible association between two SNPs in the promoter region of the CD209 gene (rs4804803 and rs2287886) and predisposition to severe forms of TBEV-induced disease was investigated. The genotypic, allelic and haplotypic frequencies of these SNPs were analyzed in 136 non-immunized Russian patients with different clinical manifestations of tick-borne encephalitis (TBE) and in a control group. An increase in the frequency of the rs2287886 SNP AA homozygotes and the A allele was detected among patients with severe central nervous system disease compared with the group of patients with meningitis (P = 0.003 and 0.019), or a combined group of patients with mild forms (fever and meningitis) (P = 0.003 and 0.026), or the control group (P = 0.007 and 0.035). Thus, our results suggest that the CD209 gene promoter region rs2287886 SNP is associated with predisposition to severe forms of TBE in the Russian population. (C) 2011 Elsevier B.V. All rights reserved. C1 [Barkhash, Andrey V.; Babenko, Vladimir N.; Voevoda, Mikhail I.] Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia. [Perelygin, Andrey A.; Brinton, Margo A.] Georgia State Univ, Dept Biol, Atlanta, GA 30303 USA. [Perelygin, Andrey A.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Voevoda, Mikhail I.] Russian Acad Med Sci, Inst Internal Med, Siberian Branch, Novosibirsk 630089, Russia. RP Barkhash, AV (reprint author), Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, 10 Lavrentyeva Ave, Novosibirsk 630090, Russia. EM barkhash@bionet.nsc.ru RI Babenko, Vladimir/K-5609-2014; OI Babenko, Vladimir/0000-0002-3077-9559 FU Russian Foundation for Basic Research [11-04-01206a]; National Center for Infectious Diseases, Centers for Disease Control and Prevention [CI000216]; University System of Georgia FX We are grateful to Aida G. Romaschenko for reading of this manuscript and helpful comments, to Pavel I. Pilipenko, Natalia G. Myasnikova, Yulia O. Bogdanova, and Olga V. Morozova for providing blood or DNA samples as well as clinical information from patients with TBE, and to Viktor F. Kobzev for providing oligonucleotide primers used in this research. This work was supported by the Russian Foundation for Basic Research (Grant No. 11-04-01206a to A.V.B. and V.N.B), National Center for Infectious Diseases, Centers for Disease Control and Prevention (Grant No. CI000216 to M.A.B. and A.A.P.) and the Global Partnership Grant from the University System of Georgia to A.A.P. NR 26 TC 22 Z9 22 U1 1 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD JAN PY 2012 VL 93 IS 1 BP 64 EP 68 DI 10.1016/j.antivira1.2011.10.017 PG 5 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA 899FP UT WOS:000300802100008 PM 22061615 ER PT J AU Chavula, C Long, D Mzembe, E Kayira, D Chasela, C Hudgens, MG Hosseinipour, M King, CC Ellington, S Chigwenembe, M Jamieson, DJ van der Horst, C AF Chavula, Charity Long, Dustin Mzembe, Enalla Kayira, Dumbani Chasela, Charles Hudgens, Michael G. Hosseinipour, Mina King, Caroline C. Ellington, Sascha Chigwenembe, Margret Jamieson, Denise J. van der Horst, Charles CA BAN Study Team TI Stopping the control arm in response to the DSMB: Mother's choice of HIV prophylaxis during breastfeeding in the BAN Study SO CONTEMPORARY CLINICAL TRIALS LA English DT Article DE Postnatal HIV transmission; Breastfeeding; Antiretorival prophylaxis ID MALAWI; TRANSMISSION; PREVENTION; INFANT AB The Data and Safety Monitoring Board (DSMB) for the Breastfeeding. Antiretrovirals, and Nutrition study, a clinical trial aimed to prevent postnatal HIV transmission, recommended halting randomization to the enhanced standard-of-care (control) arm. The 67 mother-infant pairs on the control arm and less than 21 weeks postpartum at the time of the DSMB recommendation were read a script informing them of the DSMB decision and offering them the maternal or infant antiretroviral interventions for the remainder of the 28-week breastfeeding period. This paper describes the BAN study response to the DSMB decision and what the women on the control arm chose, when given a choice to start the maternal or infant antiretroviral interventions. Published by Elsevier Inc. C1 [van der Horst, Charles] Univ N Carolina, Dept Med, Div Infect Dis, Sch Med, Chapel Hill, NC 27599 USA. [Long, Dustin; Hudgens, Michael G.] Univ N Carolina, Dept Biostat, Sch Publ Hlth, Chapel Hill, NC 27599 USA. [Chavula, Charity; Mzembe, Enalla; Kayira, Dumbani; Chasela, Charles; Hosseinipour, Mina; Chigwenembe, Margret] UNC Project, Lilongwe, Malawi. [King, Caroline C.; Ellington, Sascha; Jamieson, Denise J.] US Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP van der Horst, C (reprint author), Univ N Carolina, Dept Med, Div Infect Dis, Sch Med, CB 3368, Chapel Hill, NC 27599 USA. EM cchavula@unclilongwe.org; dustinl@email.unc.edu; enallamzembe@yahoo.co.uk; dumbanikayira@yahoo.com; cchasela@unclilongwe.org; mhudgens@bios.unc.edu; mina_hosseinipour@med.unc.edu; ccking@cdc.gov; sellington@cdc.gov; mchigwenembe@unclilongwe.org; djamieson@cdc.gov; cvdh@med.unc.edu FU Centers for Disease Control and Prevention (CDC) [SIP 13-01 U48-CCU409660-09, SIP 26-04 U48-DP000059-01, SIP 22-09 U48-DP001944-01]; National Institute of Allergy and Infectious Diseases; University of North Carolina Center for AIDS Research [P30-A150410]; NIH DHHS/NIH/FIC [DHHS/NIH/FIC 2-D43 Tw01039-06, R24TW00798]; CDC; Elizabeth Glaser Pediatric AIDS Foundation; UNICEF; World Food Programme; Malawi Ministry of Health; Johnson and Johnson; USAID FX The BAN study was supported by grants from the Prevention Research Centers Special Interest Project of the Centers for Disease Control and Prevention (CDC) (SIP 13-01 U48-CCU409660-09, SIP 26-04 U48-DP000059-01, and SIP 22-09 U48-DP001944-01), the National Institute of Allergy and Infectious Diseases, the University of North Carolina Center for AIDS Research (P30-A150410), and the NIH Fogarty AIDS International Training and Research Program (DHHS/NIH/FIC 2-D43 Tw01039-06 and R24TW00798; the American Recovery and Reinvestment Act). The CDC was the primary sponsor of the study; CDC representatives were part of the study team and therefore were involved in the study design, coordination, data collection, data analysis, data interpretation, and writing of the report The study group had full access to all data in the study and had shared responsibility for the analysis and interpretation of the data and decision to submit for publication. The antiretrovirals used in the BAN study were donated by Abbott Laboratories, GlaxoSmithKline, Boehringer-Ingelheim, Roche Pharmaceuticals and Bristol-Myers Squibb. The manufacturers had no role in the design of the study, the collection or analysis of the data, or the decision to submit the manuscript for publication. The Call to Action PMTCT program was supported by the Elizabeth Glaser Pediatric AIDS Foundation Call to Action and International Leadership Awards, UNICEF, World Food Programme, Malawi Ministry of Health, Johnson and Johnson, and USAID. NR 8 TC 6 Z9 6 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1551-7144 J9 CONTEMP CLIN TRIALS JI Contemp. Clin. Trials PD JAN PY 2012 VL 33 IS 1 BP 55 EP 59 DI 10.1016/j.cct.2011.10.006 PG 5 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA 889KL UT WOS:000300072500012 PM 22041453 ER PT J AU Pollack, KM Kercher, C Frattaroli, S Peek-Asa, C Sleet, D Rivara, FP AF Pollack, Keshia M. Kercher, Cassandra Frattaroli, Shannon Peek-Asa, Corinne Sleet, David Rivara, Frederick P. TI Toward environments and policies that promote injury-free active living-it wouldn't hurt SO HEALTH & PLACE LA English DT Review DE Physical activity; Unintentional injuries; Injury prevention; Safety ID BICYCLE SAFETY HELMETS; BUILT ENVIRONMENT; PHYSICAL-ACTIVITY; UNITED-STATES; PREVENTION; CHILDREN; PLAYGROUNDS; CHILDHOOD; OBESITY; HEALTH AB Although being active is vital to the health and well-being of children, increases in physical activity can lead to an elevated risk of injury, which is a leading cause of childhood mortality globally. This article provides an overview of the evidence base concerning unintentional injuries associated with popular forms of physical activities for youth, and describes how injury prevention and child obesity professionals can work together to prevent injuries while promoting active lifestyles. Policy and environmental interventions that are beneficial to both outcomes are highlighted and recommendations for future research for these complementary areas are also provided. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Pollack, Keshia M.; Kercher, Cassandra; Frattaroli, Shannon] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Ctr Injury Res & Policy, Baltimore, MD 21205 USA. [Peek-Asa, Corinne] Univ Iowa, Dept Occupat & Environm Hlth, Injury Prevent Res Ctr, Iowa City, IA 52242 USA. [Sleet, David] Ctr Dis Control & Prevent, Div Unintent Injury Prevent, Atlanta, GA 30341 USA. [Rivara, Frederick P.] Univ Washington, Harborview Injury Prevent & Res Ctr, Seattle, WA 98104 USA. RP Pollack, KM (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Ctr Injury Res & Policy, 624 N Broadway,Room 557, Baltimore, MD 21205 USA. EM kpollack@jhsph.edu; ckercher@jhsph.edu; sfrattar@jhsph.edu; corinne-peek-asa@uiowa.edu; dds6@cdc.gov; fpr@u.washington.edu FU Robert Wood Johnson Foundation; CDC/NCIPC [200-2009-M-31202] FX Preparation of this article was supported by Active Living Research a national program of The Robert Wood Johnson Foundation. This work was also supported by CDC/NCIPC contract 200-2009-M-31202 to the Society for the Advancement of Injury and Violence Research (SAVIR). The findings and conclusions in this report are those of the author(s) and do not necessarily represent the official views of the National Center for Injury Prevention and Control (NCIPC) or CDC. We would also like to thank Ms. Julie Gibbs from SAVIR for her assistance with this research. NR 91 TC 11 Z9 11 U1 1 U2 10 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1353-8292 J9 HEALTH PLACE JI Health Place PD JAN PY 2012 VL 18 IS 1 SI SI BP 106 EP 114 DI 10.1016/j.healthplace.2011.07.010 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 900VC UT WOS:000300918600016 PM 22243912 ER PT J AU Amburgey, JE Walsh, KJ Fielding, RR Arrowood, MJ AF Amburgey, James E. Walsh, Kimberly J. Fielding, Roy R. Arrowood, Michael J. TI Removal of Cryptosporidium and polystyrene microspheres from swimming pool water with sand, cartridge, and precoat filters SO JOURNAL OF WATER AND HEALTH LA English DT Article DE Cryptosporidium; diatomaceous earth; granular media filtration; precoat filtration; recreational water; swimming pools ID UNITED-STATES; RECREATIONAL WATER; PARVUM OOCYSTS; FILTRATION; SURVEILLANCE AB Cryptosporidium has caused the majority of waterborne disease outbreaks in treated recreational water venues in the USA for many years running. This research project evaluated some common US swimming pool filters for removing Cryptosporidium oocysts, 5-mu m diameter polystyrene microspheres, and 1-mu m diameter polystyrene microspheres. A 946 L hot tub with interchangeable sand, cartridge, and precoat filters was used at room temperature for this research. Simulated pool water for each experiment was created from Charlotte, NC (USA) tap water supplemented with alkalinity, hardness, chlorine, and a mixture of artificial sweat and urine. Precoat (i.e., diatomaceous earth and perlite) filters demonstrated pathogen removal efficiencies of 2.3 to 4.4 log (or 99.4-99.996%). However, sand and cartridge filters had average Cryptosporidium removals of 0.19 log (36%) or less. The combined low filter removal efficiencies of sand and cartridge filters along with the chlorine-resistant properties of Cryptosporidium oocysts could indicate a regulatory gap warranting further attention and having significant implications on the protection of public health in recreational water facilities. The 5-mu m microspheres were a good surrogate for Cryptosporidium oocysts in this study and hold promise for use in future research projects, field trials, and/or product testing on swimming pool filters. C1 [Amburgey, James E.; Fielding, Roy R.] Univ N Carolina, Charlotte, NC 28223 USA. [Walsh, Kimberly J.] EP Minerals, Reno, NV USA. [Arrowood, Michael J.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Amburgey, JE (reprint author), Univ N Carolina, 9201 Univ City Blvd, Charlotte, NC 28223 USA. EM jeamburg@uncc.edu FU EP Minerals FX EP Minerals generously provided funding for this research as well as the precoat filter media. Pentair Water sized and donated the centrifugal pump, three pool filters, and the PVC valves used to direct water into and out of the filters. NR 30 TC 5 Z9 5 U1 4 U2 19 PU IWA PUBLISHING PI LONDON PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND SN 1477-8920 J9 J WATER HEALTH JI J. Water Health PY 2012 VL 10 IS 1 BP 31 EP 42 DI 10.2166/wh.2011.062 PG 12 WC Environmental Sciences; Public, Environmental & Occupational Health; Microbiology; Water Resources SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Microbiology; Water Resources GA 899CS UT WOS:000300792200004 PM 22361700 ER PT J AU Xu, RH Rubio, D Roscoe, F Krouse, TE Truckenmiller, ME Norbury, CC Hudson, PN Damon, IK Alcami, A Sigal, LJ AF Xu, Ren-Huan Rubio, Daniel Roscoe, Felicia Krouse, Tracy E. Truckenmiller, Mary Ellen Norbury, Christopher C. Hudson, Paul N. Damon, Inger K. Alcami, Antonio Sigal, Luis J. TI Antibody Inhibition of a Viral Type 1 Interferon Decoy Receptor Cures a Viral Disease by Restoring Interferon Signaling in the Liver SO PLOS PATHOGENS LA English DT Article ID LETHAL MOUSEPOX MODEL; CELL-MEDIATED RESISTANCE; CD8(+) T-CELLS; VACCINIA VIRUS; I INTERFERON; IMMUNE EVASION; ECTROMELIA VIRUS; DRUG-RESISTANCE; BINDING-PROTEIN; NATURAL HOST AB Type 1 interferons (T1-IFNs) play a major role in antiviral defense, but when or how they protect during infections that spread through the lympho-hematogenous route is not known. Orthopoxviruses, including those that produce smallpox and mousepox, spread lympho-hematogenously. They also encode a decoy receptor for T1-IFN, the T1-IFN binding protein (T1-IFNbp), which is essential for virulence. We demonstrate that during mousepox, T1-IFNs protect the liver locally rather than systemically, and that the T1-IFNbp attaches to uninfected cells surrounding infected foci in the liver and the spleen to impair their ability to receive T1-IFN signaling, thus facilitating virus spread. Remarkably, this process can be reversed and mousepox cured late in infection by treating with antibodies that block the biological function of the T1-IFNbp. Thus, our findings provide insights on how T1-IFNs function and are evaded during a viral infection in vivo, and unveil a novel mechanism for antibody-mediated antiviral therapy. C1 [Xu, Ren-Huan; Rubio, Daniel; Roscoe, Felicia; Sigal, Luis J.] Fox Chase Canc Ctr, Immune Cell Dev & Host Def Program, Philadelphia, PA 19111 USA. [Rubio, Daniel; Alcami, Antonio] CSIC, Ctr Biol Mol Severo Ochoa, Madrid, Spain. [Rubio, Daniel; Alcami, Antonio] Univ Autonoma Madrid, Madrid, Spain. [Krouse, Tracy E.; Truckenmiller, Mary Ellen; Norbury, Christopher C.] Penn State Univ, Coll Med, Dept Microbiol & Immunol, Hershey, PA USA. [Hudson, Paul N.; Damon, Inger K.] Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, Div High Consequence Pathogens & Pathol, NCEZID, Atlanta, GA USA. RP Xu, RH (reprint author), Fox Chase Canc Ctr, Immune Cell Dev & Host Def Program, 7701 Burholme Ave, Philadelphia, PA 19111 USA. EM Luis.Sigal@fccc.edu RI Alcami, Antonio/F-8512-2015; OI Alcami, Antonio/0000-0002-3333-6016; Sigal, Luis/0000-0001-6642-5472 FU National Institute of Allergy and Infectious Diseases [U19AI083008, R01AI065544]; National Cancer Institute [CA006927]; Instituto de Salud Carlos III, Spanish Ministry of Health; Spanish Ministry of Science and Innovation FX This work was supported by National Institute of Allergy and Infectious Diseases grants U19AI083008 and R01AI065544 to LJS and National Cancer Institute grant CA006927 to the Fox Chase Cancer Center. DR was funded by a fellowship from Instituto de Salud Carlos III, Spanish Ministry of Health. AA was funded by the Spanish Ministry of Science and Innovation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 65 TC 12 Z9 12 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1553-7366 J9 PLOS PATHOG JI PLoS Pathog. PD JAN PY 2012 VL 8 IS 1 AR e1002475 DI 10.1371/journal.ppat.1002475 PG 12 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA 898UI UT WOS:000300767100022 PM 22241999 ER PT J AU Logan, J Skopp, NA Karch, D Reger, MA Gahm, GA AF Logan, Joseph Skopp, Nancy A. Karch, Debra Reger, Mark A. Gahm, Gregory A. TI Characteristics of Suicides Among US Army Active Duty Personnel in 17 US States From 2005 to 2007 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID DEATH REPORTING SYSTEM; VIOLENT DEATHS; SEVERE DEPRESSION; RISK-FACTORS; SURVEILLANCE; MILITARY; VETERANS AB Suicides are increasing among active duty US Army soldiers. To help focus prevention strategies, we characterized 56 US Army suicides that occurred from 2005 to 2007 in 17 US states using 2 large-scale surveillance systems. We found that intimate partner problems and military-related stress, particularly job stress, were common among decedents. Many decedents were also identified as having suicidal ideation, a sad or depressed mood, or a recent crisis before death. Focusing efforts to prevent these forms of stress might reduce suicides among soldiers. (Am J Public Health. 2012;102: S40-S44. doi:10.2105/AJPH.2011.300481) C1 [Logan, Joseph; Karch, Debra] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Div Violence Prevent, Etiol & Surveillance Branch, Atlanta, GA 30341 USA. [Skopp, Nancy A.; Reger, Mark A.; Gahm, Gregory A.] Natl Ctr Telehlth & Technol, Tacoma, WA USA. RP Logan, J (reprint author), Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Div Violence Prevent, Etiol & Surveillance Branch, 4770 Buford Highway,MS-F63, Atlanta, GA 30341 USA. EM ffa3@cdc.gov FU Centers for Disease Control and Prevention; National Center for Telehealth and Technology FX We would like to thank all of the staff at the Centers for Disease Control and Prevention and the National Center for Telehealth and Technology who helped support this project, especially those who helped with the data linkage. NR 23 TC 14 Z9 14 U1 1 U2 8 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PY 2012 VL 102 SU 1 BP S40 EP S44 DI 10.2105/AJPH.2011.300481 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 893EO UT WOS:000300338600016 PM 22390599 ER PT J AU Azziz-Baumgartner, E Alamgir, ASM Rahman, M Homaira, N Sohel, BM Sharker, MAY Zaman, RU Dee, J Gurley, ES Al Mamun, A Mah-E-Muneer, S Fry, AM Widdowson, MA Bresee, J Lindstrom, S Azim, T Brooks, A Podder, G Hossain, MJ Rahman, M Luby, SP AF Azziz-Baumgartner, Eduardo Alamgir, A. S. M. Rahman, Mustafizur Homaira, Nusrat Sohel, Badrul Munir Sharker, M. A. Yushuf Zaman, Rashid Uz Dee, Jacob Gurley, Emily S. Al Mamun, Abdullah Mah-E-Muneer, Syeda Fry, Alicia M. Widdowson, Marc-Alain Bresee, Joseph Lindstrom, Stephen Azim, Tasnim Brooks, Abdullah Podder, Goutam Hossain, M. Jahangir Rahman, Mahmudur Luby, Stephen P. TI Incidence of influenza-like illness and severe acute respiratory infection during three influenza seasons in Bangladesh, 2008-2010 SO BULLETIN OF THE WORLD HEALTH ORGANIZATION LA English DT Article ID UNITED-STATES; BURDEN; SURVEILLANCE; VIRUS; EPIDEMIOLOGY; MORTALITY; DISEASE; COST AB Objective To determine how much influenza contributes to severe acute respiratory illness (SARI), a leading cause of death in children, among people of all ages in Bangladesh. Methods Physicians obtained nasal and throat swabs to test for influenza virus from patients who were hospitalized within 7 days of the onset of severe acute respiratory infection (SARI) or who consulted as outpatients for influenza-like illness (ILI). A community health care utilization survey was conducted to determine the proportion of hospital catchment area residents who sought care at study hospitals and calculate the incidence of influenza using this denominator. Findings The estimated incidence of SARI associated with influenza in children <5 years old was 6.7 (95% confidence interval, CI: 0-18.3); 4.4 (95% CI: 0-13.4) and 6.5 per 1000 person years (95% CI: 0-8.3/1000) during the 2008, 2009 and 2010 influenza seasons, respectively. The incidence of SARI in people aged >= 5 years was 1.1 (95% CI: 0.4-2.0) and 1.3 (95% CI: 0.5-2.2) per 10000 person-years during 2009 and 2010, respectively. The incidence of medically attended, laboratory-confirmed seasonal influenza in outpatients with ILI was 10 (95% CI: 8-14), 6.6 (95% CI: 5-9) and 17 per 100 person-years (95% CI: 13-22) during the 2008, 2009 and 2010 influenza seasons, respectively. Conclusion Influenza-like illness is a frequent cause of consultation in the outpatient setting in Bangladesh. Children aged less than 5 years are hospitalized for influenza in greater proportions than children in other age groups. C1 [Azziz-Baumgartner, Eduardo; Rahman, Mustafizur; Homaira, Nusrat; Sohel, Badrul Munir; Sharker, M. A. Yushuf; Zaman, Rashid Uz; Dee, Jacob; Gurley, Emily S.; Al Mamun, Abdullah; Mah-E-Muneer, Syeda; Azim, Tasnim; Brooks, Abdullah; Podder, Goutam; Hossain, M. Jahangir] Int Ctr Diarrhoeal Dis Res, Dhaka 1212, Bangladesh. [Alamgir, A. S. M.; Rahman, Mahmudur] Inst Epidemiol Dis Control & Res, Dhaka, Bangladesh. [Fry, Alicia M.; Widdowson, Marc-Alain; Bresee, Joseph; Lindstrom, Stephen; Luby, Stephen P.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Azziz-Baumgartner, E (reprint author), Int Ctr Diarrhoeal Dis Res, 68 Shaheed Tajuddin Ahmed, Dhaka 1212, Bangladesh. EM eha9@cdc.gov RI rahman, mustafizur/E-6918-2010; Gurley, Emily/B-7903-2010; OI Gurley, Emily/0000-0002-8648-9403; Widdowson, Marc-Alain/0000-0002-0682-6933 FU United States Centers for Disease Control and Prevention [U01/CI000628-02] FX This Study was funded by the United States Centers for Disease Control and Prevention; grant number U01/CI000628-02. NR 29 TC 42 Z9 42 U1 0 U2 2 PU WORLD HEALTH ORGANIZATION PI GENEVA 27 PA MARKETING AND DISSEMINATION, CH-1211 GENEVA 27, SWITZERLAND SN 0042-9686 J9 B WORLD HEALTH ORGAN JI Bull. World Health Organ. PD JAN PY 2012 VL 90 IS 1 BP 12 EP 19 DI 10.2471/BLT.11.090209 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 887FZ UT WOS:000299913600018 PM 22271960 ER PT J AU Onyekwuluje, JM Steinau, M Swan, DC Unger, ER AF Onyekwuluje, Juanita M. Steinau, Martin Swan, David C. Unger, Elizabeth R. TI A Real-Time PCR Assay for HPV52 Detection and Viral Load Quantification SO CLINICAL LABORATORY LA English DT Article DE Human Papillomavirus (HPV) type 52; HPV detection; real-time PCR ID PAPILLOMAVIRUS; CONFIRMATION AB Background: Human papillomavirus (HPV) 52 is one of the most frequent high risk HPV types found in cervical and anal infections. Reliable and well characterized methods for HPV 52 detection are therefore of great importance. Unfortunately one of the most widely used commercially available HPV typing assays, the Roche Linear Array (LA), detects type 52 only through its XR probe which cross-reacts with types 33, 35 and 58 and fails to give unambiguous detection of HPV 52. Methods: To address this problem a real-time TaqMan PCR assay for HPV 52 targeting the E6/E7 region was developed and validated, which can be applied as robust duplex assay simultaneously detecting beta-globin as genomic control and reference or as highly sensitive single target detection assay. Results: Optimized primer and probe concentrations produced linear PCR amplifications over seven logs of targets (10(1) - 10(7)). The detection limit for HPV 52 was reproducibly at 10 copies per reaction for the duplex assay format and 5 copies for the single-plex format. The assay was,cry type-specific and no amplification signal was observed with 10(7) copies of the related HPV33, 35, and 58 DNA. Of 89 samples that tested unambiguously positive for HPV 52 in the LA, 75 were confirmed in the duplex format and 88 in the single-plex format. An additional 100 samples negative for HPV 52 in LA were all negative in both HPV 52 real-time PCR assay formats. Conclusions: These results indicate 92.6% and 99.5% accuracy relative to LA for the duplex and single-plex formats, respectively. In ongoing testing of 18,484 from various studies, 10.8% required the HPV52 TaqMan assay to unequivocally determine the status. Including the HPV 52 duplex assay provides the ability to monitor variations in the cell yield in various methods of sample collection and processing. This additional information is useful in QC monitoring of epidemiologic studies. (Clin. Lab. 2012;58:61-66) C1 [Onyekwuluje, Juanita M.; Steinau, Martin; Swan, David C.; Unger, Elizabeth R.] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div High Consequence Pathogens & Pathol, Chron Viral Dis Branch, Atlanta, GA 30333 USA. RP Onyekwuluje, JM (reprint author), Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div High Consequence Pathogens & Pathol, Chron Viral Dis Branch, 1600 Clifton Rd,G41, Atlanta, GA 30333 USA. EM JOnyekwuluje@cdc.gov OI Unger, Elizabeth/0000-0002-2925-5635 NR 7 TC 17 Z9 17 U1 1 U2 2 PU CLIN LAB PUBL PI HEIDELBERG PA IM BREITSPIEL 15, HEIDELBERG, D-69126, GERMANY SN 1433-6510 J9 CLIN LAB JI Clin. Lab. PY 2012 VL 58 IS 1-2 BP 61 EP 66 PG 6 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 893EU UT WOS:000300339200007 PM 22372346 ER PT J AU Teitelbaum, SL Mervish, N Moshier, EL Vangeepuram, N Galvez, MP Calafat, AM Silva, MJ Brenner, BL Wolff, MS AF Teitelbaum, Susan L. Mervish, Nancy Moshier, Erin L. Vangeepuram, Nita Galvez, Maida P. Calafat, Antonia M. Silva, Manori J. Brenner, Barbara L. Wolff, Mary S. TI Associations between phthalate metabolite urinary concentrations and body size measures in New York City children SO ENVIRONMENTAL RESEARCH LA English DT Article DE Body mass index; Children; Obesity; Phthalates; Waist circumference ID WAIST CIRCUMFERENCE; MASS INDEX; DI(2-ETHYLHEXYL) PHTHALATE; RISK-FACTORS; OBESITY; TESTOSTERONE; ADOLESCENTS; PERFORMANCE; POPULATION; ACTIVATION AB Objective: To examine prospectively associations between urinary phthalate metabolite concentrations and body size measures in children. Methods: Urinary concentrations of nine phthalate metabolites: monoethyl (MEP); mono-n-butyl (MBP); mono-(3-carboxypropyl) (MCPP); monobenzyl (MBzP); mono-isobutyl (MiBP); mono-(2-ethylhexyl) (MEHP); mono-(2-ethyl-5-oxohexyl) (MEOHP); mono-(2-ethyl-5-carboxypentyl) (MECPP); and mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and the molar sum of the low molecular-weight phthalate metabolites (low MWP: MEP, MBP and MiBP) and high molecular-weight phthalate metabolites (high MWP: MECPP, MEHHP, MEOHP, MEHP and MBzP) and of four di-(2-ethylhexyl) phthalate (DEHP) metabolites (Sigma DEHP: MEHP, MEHHP, MEOHP, MECPP) and anthropometry, including body mass index and waist circumference were measured among 387 Hispanic and Black, New York City children who were between six and eight years at cohort enrollment (2004-2007). Relationships between baseline metabolite concentrations and body size characteristics obtained one year later were examined using multivariate-adjusted geometric means for each body size characteristic by continuous and categories of phthalate metabolite concentrations. Stratified analyses by body size (age/sex specific) were conducted. Results: No significant associations are reported among all girls or boys. Dose response relationships were seen with monoethyl phthalate and the sum of low molecular-weight phthalates and body mass index and waist circumference among overweight children; for increasing monoethyl phthalate concentration quartiles among girls, adjusted mean body mass indexes were as follows: 21.3, 21.7, 23.8, 23.5 and adjusted mean waist circumference (cm) were as follows: 73.4, 73.5, 79.2, 78.8 (p-trend < 0.001 for both). Conclusion: In this prospective analysis we identified positive relationships between urinary concentrations of monoethyl phthalate and the sum of low molecular-weight phthalates and body size measures in overweight children. These are metabolites with concentrations above 1 mu M. (C) 2011 Elsevier Inc. All rights reserved. C1 [Teitelbaum, Susan L.; Mervish, Nancy; Moshier, Erin L.; Vangeepuram, Nita; Galvez, Maida P.; Brenner, Barbara L.; Wolff, Mary S.] Mt Sinai Sch Med, Dept Prevent Med, New York, NY 10029 USA. [Vangeepuram, Nita; Galvez, Maida P.] Mt Sinai Sch Med, Dept Pediat, New York, NY 10029 USA. [Calafat, Antonia M.; Silva, Manori J.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Teitelbaum, SL (reprint author), Mt Sinai Sch Med, Dept Prevent Med, 1 Gustave L Levy Pl,Box 1057, New York, NY 10029 USA. EM Susan.Teitelbaum@mssm.edu FU National Institute of Environmental Health Sciences (NIEHS)/National Cancer Institute [ES012771]; NIEHS [ES12645]; NIEHS/U.S. Environmental Protection Agency Children's Center [ES09584, R827039]; Agency for Toxic Substances and Disease Registry ATSDR [ATU 300014, HD049311]; National Center for Research Resources (NCRR) [MO1-RR-00071] FX This research was supported by National Institute of Environmental Health Sciences (NIEHS)/National Cancer Institute ES012771; NIEHS ES12645; NIEHS/U.S. Environmental Protection Agency Children's Center grants ES09584 and R827039; the Agency for Toxic Substances and Disease Registry ATSDR Grant #ATU 300014 the Pediatric Environmental Health Fellowship HD049311 and National Center for Research Resources (NCRR) MO1-RR-00071. NR 45 TC 58 Z9 60 U1 2 U2 16 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0013-9351 J9 ENVIRON RES JI Environ. Res. PD JAN PY 2012 VL 112 BP 186 EP 193 DI 10.1016/j.envres.2011.12.006 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 885TX UT WOS:000299804800024 PM 22222007 ER PT J AU Li, RX Stewart, B Weiskittel, A AF Li, Rongxia Stewart, Brock Weiskittel, Aaron TI A Bayesian approach for modelling non-linear longitudinal/hierarchical data with random effects in forestry SO FORESTRY LA English DT Article ID MIXED EFFECTS MODELS; LONGITUDINAL DATA; HEIGHT GROWTH; DISTRIBUTIONS; PREDICTION; ERRORS AB Longitudinal or hierarchical data are often observed in forestry, which can pose both challenges and opportunities when performing statistical analyses. The current standard approach for analysing these types of data is mixed-effects models under the frequentist paradigm. Bayesian techniques have several advantages when compared with traditional approaches, but their use in forestry has been relatively limited. In this paper, we propose a Bayesian solution to non-linear mixed-effects models for longitudinal data in forestry. We demonstrate the Bayesian modelling process using individual tree height-age data for balsam fir (Abies balsamea (L.)) collected from eastern Maine. Due to its frequent utilization in modelling dominant tree height growth over time, we choose to examine models based on the Chapman-Richards function. We established four different model formulations, each having varying subject-specific parameters, which we estimated using both frequentist and Bayesian approaches. We found the estimation results to be quite close between the two methods. In addition, an important feature of the Bayesian method is the unified manner in which estimation and prediction are handled. Specifically, local parameters can be predicted for a new dataset after setting the posterior distributions from the estimation stage as new priors in the prediction phase. C1 [Li, Rongxia; Weiskittel, Aaron] Univ Maine, Sch Forest Resources, Orono, ME 04469 USA. [Stewart, Brock] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Li, RX (reprint author), Univ Maine, Sch Forest Resources, 5755 Nutting Hall, Orono, ME 04469 USA. EM rongxia.li@umit.maine.edu FU Forest Bioproducts Research Institute; University of Maine, School of Forest Resources, Cooperative Forestry Research Unit FX Funding was provided by the University of Maine, School of Forest Resources, Cooperative Forestry Research Unit, and the Forest Bioproducts Research Institute. NR 44 TC 9 Z9 13 U1 5 U2 25 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0015-752X J9 FORESTRY JI Forestry PD JAN PY 2012 VL 85 IS 1 BP 17 EP 25 DI 10.1093/forestry/cpr050 PG 9 WC Forestry SC Forestry GA 891TF UT WOS:000300238800002 ER PT J AU Hartman, TJ Mahabir, S Baer, DJ Stevens, RG Albert, PS Dorgan, JF Kesner, JS Meadows, JW Shields, R Taylor, PR AF Hartman, T. J. Mahabir, S. Baer, D. J. Stevens, R. G. Albert, P. S. Dorgan, J. F. Kesner, J. S. Meadows, J. W. Shields, R. Taylor, P. R. TI Moderate Alcohol Consumption and 24-Hour Urinary Levels of Melatonin in Postmenopausal Women SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article ID BREAST-CANCER RISK; NIGHT WORK; 6-SULFATOXYMELATONIN; ETHANOL; SECRETION; LIGHT AB Context: Low overnight urinary melatonin metabolite concentrations have been associated with increased risk for breast cancer among postmenopausal women. The Postmenopausal Women's Alcohol Study was a controlled feeding study to test the effects of low to moderate alcohol intake on potential risk factors for breast cancer including serum and urinary levels of hormones and other biomarkers. Previously, we observed significant increases in concentrations of serum estrone sulfate and dehydroepiandrosterone sulfate in participants after consumption of 15 or 30 g (one or two drinks) of alcohol per day. Objective: In the present analysis, we evaluated the relationship of alcohol consumption with 24-h urinary 6-sulfatoxymelatonin (6-SMT) concentration (micrograms per 24 h). Design and Participants: Healthy postmenopausal women(n = 51) consumed a controlled diet plus each of three treatments (a nonalcoholic placebo beverage or 15 or 30 g alcohol/d) during three 8-wk periods in random order under conditions of weight maintenance. Measures: 6-SMT was measured in 24-h urine samples that were collected at entry into the study (baseline) and at the midpoint (4 wk) and end (8 wk) of each of the three diet periods. Results: Concentration of 6-SMT was not significantly modified by the alcohol treatment after adjustment for body mass index, hours of sleep, daylight hours, and baseline level of 6-SMT. Conclusions: These results suggest that low to moderate daily alcohol consumption does not significantly affect 24-h urinary levels of melatonin among healthy postmenopausal women.(J Clin Endocrinol Metab 97: E65-E68, 2012) C1 [Hartman, T. J.] Penn State Univ, Chandlee Lab 110, Dept Nutr Sci, University Pk, PA 16802 USA. [Hartman, T. J.; Taylor, P. R.] NCI, Genet Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Mahabir, S.] NCI, Modifiable Risk Factors Branch, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. [Baer, D. J.] USDA, Beltsville Human Nutr Res Ctr, Beltsville, MD 20705 USA. [Stevens, R. G.] Univ Connecticut, Ctr Hlth, Dept Community Med & Hlth Care, Farmington, CT 06032 USA. [Albert, P. S.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Biostat & Bioinformat Branch, Bethesda, MD 20892 USA. [Dorgan, J. F.] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA. [Kesner, J. S.; Meadows, J. W.] NIOSH, Reprod Hlth Assessment Team, Cincinnati, OH 45226 USA. [Shields, R.] Informat Management Serv Inc, Silver Spring, MD 20904 USA. RP Hartman, TJ (reprint author), Penn State Univ, Chandlee Lab 110, Dept Nutr Sci, University Pk, PA 16802 USA. EM tjh9@psu.edu FU National Institutes of Health, National Cancer Institute; Division of Cancer Epidemiology and Genetics and the Agricultural Research Service, U.S. Department of Agriculture FX This research was supported by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, and the Division of Cancer Epidemiology and Genetics and the Agricultural Research Service, U.S. Department of Agriculture. NR 20 TC 4 Z9 4 U1 2 U2 4 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0021-972X J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD JAN PY 2012 VL 97 IS 1 BP E65 EP E68 DI 10.1210/jc.2011-1904 PG 4 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 893YM UT WOS:000300393800010 PM 22013099 ER PT J AU Okonji, JA Basavaraju, SV Mwangi, J Shiraishi, RW Odera, M Ouma, K Pitman, JP Marum, LH Ou, CY Zeh, C AF Okonji, Jully A. Basavaraju, Sridhar V. Mwangi, Jane Shiraishi, Ray W. Odera, Matthew Ouma, Kenneth Pitman, John P. Marum, Lawrence H. Ou, Chin-Yih Zeh, Clement TI Comparison of HIV-1 detection in plasma specimens and dried blood spots using the Roche COBAS Ampliscreen HIV-1 test in Kisumu, Kenya SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE HIV-1; Blood donors; Nucleic acid testing; Dried blood spots ID HUMAN-IMMUNODEFICIENCY-VIRUS; HEPATITIS-B-VIRUS; STORAGE-CONDITIONS; SOUTH-AFRICA; P24 ANTIGEN; TYPE-1 RNA; TRANSFUSION; SENSITIVITY; SAMPLES; RISK AB The World Health Organization recommends screening donor blood for HIV in centralized laboratories. This recommendation contributes to quality, but presents specimen transport challenges for resource-limited settings which may be relieved by using dried blood spots (DBS). In sub-Saharan Africa, most countries screen donor blood with serologic assays only. Interest in window period reduction has led blood services to consider adding HIV nucleic acid testing (NAT). The U.S. Food and Drug Administration (FDA) mandates that HIV-1 NAT blood screening assays have a 95% detection limit at or below 100 copies/ml and 5000 copies/ml for pooled and individual donations, respectively. The Roche COBAS Ampliscreen HIV-1 test, version 1.5, used for screening whole blood or components for transfusion, has not been tested with DBS. We compared COBAS Ampliscreen HIV-1 RNA detection limits in DBS and plasma. An AIDS Clinical Trials Group, Viral Quality Assurance laboratory HIV-1 standard with a known viral load was used to create paired plasma and DBS standard nine member dilution series. Each was tested in 24 replicates with the COBAS Ampliscreen. A probit analysis was conducted to calculate 95% detection limits for plasma and DBS, which were 23.8 copies/ml (95% CI 15.1-51.0) for plasma and 106.7 copies/ml (95% CI 73.8-207.9) for DBS. The COBAS Ampliscreen detection threshold with DBS suggests acceptability for individual donations, but optimization may be required for pooled specimens. Published by Elsevier B.V. C1 [Basavaraju, Sridhar V.; Shiraishi, Ray W.; Pitman, John P.; Marum, Lawrence H.; Ou, Chin-Yih] US Ctr Dis Control & Prevent, Ctr Global Hlth, Div Global HIV AIDS, Atlanta, GA 30333 USA. [Okonji, Jully A.; Ouma, Kenneth] Kenya Med Res Inst KEMRI, Ctr Biomed Res & Technol, Kisumu, Kenya. [Mwangi, Jane; Zeh, Clement] US Ctr Dis Control & Prevent, Kisumu, Kenya. [Odera, Matthew] Kisumu Reg Blood Transfus Ctr, Kenya Natl Blood Transfus Serv, Kisumu, Kenya. RP Basavaraju, SV (reprint author), US Ctr Dis Control & Prevent, Ctr Global Hlth, Div Global HIV AIDS, 1600 Clifton Rd,NE MS E04, Atlanta, GA 30333 USA. EM jokonji@ke.cdc.gov; etu7@cdc.gov; jwmwangi@ke.cdc.gov; fnf3@cdc.gov; kouma@ke.cdc.gov; pitmanj@na.cdc.gov; maruml@zm.cdc.gov; cho2@cn.cdc.gov; czeh@ke.cdc.gov OI Pitman, John/0000-0001-5983-7241 FU President's Emergency Plan for AIDS Relief (PEPFAR) FX The authors thank Rebecca L. Achieng and Bethwel Kiplagat of KEMRI for assistance with laboratory testing, and Bharat Parekh and Jerry A. Holmberg for critical review and advice. Funding for this testing was provided by the President's Emergency Plan for AIDS Relief (PEPFAR). Funding was provided by PEPFAR to CDC. CDC staff participated in the design, data collection, analysis, and interpretation of the data, as well as in writing the manuscript and the decision to submit it for publication. This paper is published with the permission of the Director-KEMRI. NR 28 TC 5 Z9 5 U1 1 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 J9 J VIROL METHODS JI J. Virol. Methods PD JAN PY 2012 VL 179 IS 1 BP 21 EP 25 DI 10.1016/j.jviromet.2011.07.001 PG 5 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA 891HL UT WOS:000300207700004 PM 21777620 ER PT B AU Diamond, MS Pierson, TC Roehrig, JT AF Diamond, Michael S. Pierson, Theodore C. Roehrig, John T. BE Shi, PY TI Antibody Therapeutics Against Flaviviruses SO MOLECULAR VIROLOGY AND CONTROL OF FLAVIVIRUSES LA English DT Article; Book Chapter ID WEST-NILE-VIRUS; JAPANESE ENCEPHALITIS-VIRUS; TICK-BORNE ENCEPHALITIS; YELLOW-FEVER VIRUS; NONSTRUCTURAL PROTEIN NS1; HUMANIZED MONOCLONAL-ANTIBODY; LETHAL DENGUE INFECTION; TYPE-2 ENVELOPE PROTEIN; VIRAL MEMBRANE-FUSION; 17D VACCINE STRAIN AB Flaviviruses are a group of small RNA enveloped viruses that cause severe disease in humans worldwide. Recent advances in the structural biology of the flavivirus envelope proteins and virion have catalysed rapid progress towards understanding how the most potently inhibitory antibodies neutralize infection. These insights have identified factors that modulate the potency of neutralizing antibodies and provided insight into the design of novel antibody-based therapeutics against several members of the flavivirus genus. This chapter will discuss recent advances in the understanding of the mechanisms of antibody neutralization of flaviviruses, and review the progress towards development of antibody-based therapeutics against several different flaviviruses of global concern. C1 [Diamond, Michael S.] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA. [Diamond, Michael S.] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA. [Diamond, Michael S.] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA. [Diamond, Michael S.] Washington Univ, Sch Med, Midwest Reg Ctr Excellence Biodef & Emerging, St Louis, MO 63110 USA. [Roehrig, John T.] US Dept Hlth & Human Serv, Div Vector Borne Infect Dis, Ctr Dis Control & Prevent, Publ Hlth Serv, Ft Collins, CO USA. [Pierson, Theodore C.] NIH, Viral Pathogenesis Sect, Viral Dis Lab, Bethesda, MD 20892 USA. RP Diamond, MS (reprint author), Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA. EM diamond@borcim.wustl.edu; piersontc@mail.nih.gov; jtr1@cdc.gov NR 223 TC 6 Z9 6 U1 0 U2 1 PU CAISTER ACADEMIC PRESS PI WYMONDHAM PA 32 HEWITTS LANE, WYMONDHAM NR 18 0JA, ENGLAND BN 978-1-904455-92-9 PY 2012 BP 231 EP 255 PG 25 WC Virology SC Virology GA BYM17 UT WOS:000299300400011 ER PT B AU Hunsperger, E AF Hunsperger, Elizabeth BE Shi, PY TI Flavivirus Diagnostics SO MOLECULAR VIROLOGY AND CONTROL OF FLAVIVIRUSES LA English DT Article; Book Chapter ID WEST-NILE-VIRUS; JAPANESE ENCEPHALITIS-VIRUS; LINKED-IMMUNOSORBENT-ASSAY; TICK-BORNE ENCEPHALITIS; NONSTRUCTURAL PROTEIN NS1; ST-LOUIS ENCEPHALITIS; TRANSCRIPTASE PCR ASSAYS; ORIGINAL ANTIGENIC SIN; IMMUNOGLOBULIN-M IGM; GROUP-B ARBOVIRUSES AB Within the family of Flaviviridae there are many medically important viruses that cause human disease worldwide. These viruses were originally categorized based on phenotype due to their antigenic relatedness and placed within groups, subgroups and types and later confirmed with nucleic acid sequence analysis. Diagnosis of disease caused by flaviviruses has been primarily based on serological identification of antiviral antibodies and virus isolation. Some of the classic serological techniques of haemagglutination inhibition assay and complement fixation were replaced with the enzyme linked immunosorbent assay (ELISA) for the detection of IgM, IgG and IgA antibodies primarily due to ease-of-use. The plaque reduction neutralization test (PRNT) provided the specificity needed for virus identification following a positive serological test by ELISA. The development of polymerase chain reaction (PCR) assays improved the ability to detect virus nucleic acid sequence when viral isolates were not obtained. Because reverse transcriptase PCR (RT-PCR) assays are easy to perform, have increased sensitivity and provide virus identification in a short period of time, RT-PCR has essentially replaced isolation techniques for rapid diagnosis. However, virus isolation is still essential for genetic analysis. The future of flaviviral disease diagnosis is new platforms for antibody and nucleic acid detection as well as the development of point-of-care diagnostics for clinical management. C1 Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Serol Diagnost & Viral Pathogenesis Lab Dengue Br, San Juan, PR USA. RP Hunsperger, E (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Serol Diagnost & Viral Pathogenesis Lab Dengue Br, San Juan, PR USA. EM enh4@cdc.gov NR 123 TC 1 Z9 1 U1 0 U2 3 PU CAISTER ACADEMIC PRESS PI WYMONDHAM PA 32 HEWITTS LANE, WYMONDHAM NR 18 0JA, ENGLAND BN 978-1-904455-92-9 PY 2012 BP 271 EP 296 PG 26 WC Virology SC Virology GA BYM17 UT WOS:000299300400013 ER PT J AU MacDorman, MF Declercq, E Mathews, TJ MacDorman, MF Mathews, TJ AF MacDorman, Marian F. Declercq, Eugene Mathews, T. J. MacDorman, Marian F. Mathews, T. J. TI United States Home Births Increase 20 Percent From 2004 to 2008 EDITORIAL COMMENT SO OBSTETRICAL & GYNECOLOGICAL SURVEY LA English DT Editorial Material AB A hundred years ago, the vast majority of births in the United States took place at home. In the past 10 decades, there has been a major shift in childbearing patterns. By the 1940s, less than half of deliveries occurred at home. The percentage of home deliveries by 1969 declined to about 1%, and the rates stabilized in the next 2 decades. Following a gradual decline from 1990 to 2004, the percentage of births occurring at home increased from 0.56% in 2004 to 0.67% in 2008, which represents an increase of 20%. The reasons for this increase are unclear. The primary aim of this report was to investigate the factors associated with the increase in percentage of home births from 2004 to 2008. Data were obtained from birth certificates on live births registered in the United States; maternal demographic and medical characteristics were analyzed. There were a total of 28,357 home births in the United States in 2008. The rise in percentage of home births occurring from 2004 to 2008 was associated with a 28% increase (from 0.80% to 1.02%) in delivery at home among non-Hispanic white women who account for 83% of home births. The rest of the racial/ethnic subgroups were either unchanged or minimally changed during the study years. Moreover, an improved risk profile for women delivering at home over the 4 years of the study was demonstrated by the finding of substantial decreases in the percentage of home births of infants born either preterm or at low birth weight and those born to teenage and unwed mothers. From 2004 to 2008, statistically significant increases occurred in the percentage of home births in 27 states; declines were noted in only 4 states. These findings suggest that the 20% increase in United States home births from 2004 to 2008 may be associated with an improved risk profile in women delivering at home. The authors note that increasing numbers of home births are planned as more women opt for a home birth. C1 [MacDorman, Marian F.; Mathews, T. J.; MacDorman, Marian F.; Mathews, T. J.] Ctr Dis Control & Prevent, Statisticians Reprod Stat Branch, Div Vital Stat, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Declercq, Eugene] Boston Univ, Sch Publ Hlth, Dept Community Hlth Sci, Boston, MA USA. RP MacDorman, MF (reprint author), Ctr Dis Control & Prevent, Statisticians Reprod Stat Branch, Div Vital Stat, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7828 J9 OBSTET GYNECOL SURV JI Obstet. Gynecol. Surv. PD JAN PY 2012 VL 67 IS 1 BP 8 EP 10 DI 10.1097/OGX.0b013e3182439df7 PG 3 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 891MD UT WOS:000300220300003 ER PT J AU Nater, UM Maloney, E Lin, JMS Heim, C Reeves, WC AF Nater, Urs M. Maloney, Elizabeth Lin, Jin-Mann S. Heim, Christine Reeves, William C. TI Coping Styles in Chronic Fatigue Syndrome: Findings from a Population-Based Study SO PSYCHOTHERAPY AND PSYCHOSOMATICS LA English DT Letter C1 [Lin, Jin-Mann S.; Reeves, William C.] Ctr Dis Control & Prevent, Publ Hlth Surveillance Program Off, Off Surveillance Epidemiol & Lab Serv, Atlanta, GA 30333 USA. [Nater, Urs M.; Maloney, Elizabeth] Ctr Dis Control & Prevent, Chron Viral Dis Branch, Div High Consequence Pathogens & Pathol Proposed, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Heim, Christine] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA. [Nater, Urs M.] Univ Marburg, Dept Psychol, D-3550 Marburg, Germany. RP Reeves, WC (reprint author), Ctr Dis Control & Prevent, Publ Hlth Surveillance Program Off, Off Surveillance Epidemiol & Lab Serv, Mail Stop E-33,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM wcr1@cdc.gov RI Heim, Christine/A-1183-2009; Nater, Urs/J-6898-2013; OI Nater, Urs/0000-0002-2430-5090 NR 14 TC 1 Z9 1 U1 1 U2 12 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0033-3190 J9 PSYCHOTHER PSYCHOSOM JI Psychother. Psychosom. PY 2012 VL 81 IS 2 BP 127 EP 129 DI 10.1159/000329996 PG 3 WC Psychiatry; Psychology SC Psychiatry; Psychology GA 894JE UT WOS:000300422200010 PM 22301698 ER PT J AU Benitez, AJ Thurman, KA Diaz, MH Conklin, L Kendig, NE Winchell, JM AF Benitez, Alvaro J. Thurman, Kathleen A. Diaz, Maureen H. Conklin, Laura Kendig, Newton E. Winchell, Jonas M. TI Comparison of Real-Time PCR and a Microimmunofluorescence Serological Assay for Detection of Chlamydophila pneumoniae Infection in an Outbreak Investigation SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID CHLAMYDIA-PNEUMONIAE; MYCOPLASMA-PNEUMONIAE; RESPIRATORY-INFECTION; QUANTITATIVE PCR; IDENTIFICATION; ANTIBODIES; DIAGNOSIS AB We assessed the performance of a recently validated real-time PCR assay and a commercially available microimmunofluorescence serologic test for the detection of Chlamydophila pneumoniae infection during an outbreak. Evaluation of specimens from 137 individuals suggests that real-time PCR holds greater utility as a diagnostic tool for early C. pneumoniae detection. C1 [Benitez, Alvaro J.; Thurman, Kathleen A.; Diaz, Maureen H.; Conklin, Laura; Winchell, Jonas M.] Ctr Dis Control & Prevent, Resp Dis Branch, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Kendig, Newton E.] Fed Bur Prisons, Hlth Serv Div, Washington, DC USA. RP Winchell, JM (reprint author), Ctr Dis Control & Prevent, Resp Dis Branch, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM jwinchell@cdc.gov NR 23 TC 10 Z9 10 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JAN PY 2012 VL 50 IS 1 BP 151 EP 153 DI 10.1128/JCM.05357-11 PG 3 WC Microbiology SC Microbiology GA 888IH UT WOS:000299996600028 PM 22031704 ER PT J AU Liu, PB Hill, VR Hahn, D Johnson, TB Pan, Y Jothikumar, N Moe, CL AF Liu, Pengbo Hill, Vincent R. Hahn, Donghyun Johnson, Trisha B. Pan, Yi Jothikumar, Narayanan Moe, Christine L. TI Hollow-fiber ultrafiltration for simultaneous recovery of viruses, bacteria and parasites from reclaimed water SO JOURNAL OF MICROBIOLOGICAL METHODS LA English DT Article DE Ultrafiltration; Reclaimed water; Pathogens; Elution; Blocking ID MULTIPLE MICROBE CLASSES; MEMBRANE FILTRATION; TAP WATER; DIVERSE MICROBES; DRINKING-WATER; SYSTEMS; SAMPLES; PERFRINGENS; CALIFORNIA; QUALITY AB Hollow-fiber ultrafiltration (UF) is a technique that has been reported to be effective for recovering a diverse array of microbes from water, and may also be potentially useful for microbial monitoring of effluent from water reclamation facilities. However, few data are available to indicate the potential limitations and efficacy of the UF technique for treated wastewater. In this study, recovery efficiencies were determined for various options available for performing the tangential-flow UF technique, including hollow-fiber ultrafilter (i.e., dialyzer) type, ultrafilter pre-treatment (i.e., blocking), and elution. MS2 and Phi X174 bacteriophages, Clostridium perfringens spores, Escherichia coli, and Cryptosporidium parvum oocysts were seeded into 10-L reclaimed water samples to evaluate UF options. Then a single UF protocol was established and studied using seeded and non-seeded 100-L samples from two water reclamation facilities in Georgia, USA. Baxter Exeltra Plus 210 and Fresenius F200NR dialyzers were found to provide significantly higher microbial recovery than Minntech HPH 1400 hemoconcentrators. The selected final UF method incorporated use of a non-blocked ultrafilter for UF followed by elution using a surfactant-based solution. For 10-L samples, this method achieved recovery efficiencies of greater than 50% recovery of seeded viruses, bacteria, and parasites. There was no significant difference in overall microbial recovery efficiency when the method was applied to 10- and 100-L samples. In addition, detection levels for pathogens in seeded 100-L reclaimed water samples were 1000 PFU HAV, 10,000 GI norovirus particles, <500 Salmonella and <200 Cryptosporidium oocysts. These data demonstrate that UF can be an effective technique for recovering diverse microbes in reclaimed water to monitor and improve effluent water quality in wastewater treatment plants. Published by Elsevier B.V. C1 [Hill, Vincent R.; Hahn, Donghyun; Johnson, Trisha B.; Jothikumar, Narayanan] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30329 USA. [Liu, Pengbo; Moe, Christine L.] Emory Univ, Hubert Dept Global Hlth, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Hahn, Donghyun; Johnson, Trisha B.] Atlanta Res & Educ Fdn, Atlanta, GA 30033 USA. [Pan, Yi] Emory Univ, Dept Biostat & Bioinformat, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. RP Hill, VR (reprint author), Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Foodborne Waterborne & Environm Dis, 1600 Clifton Rd NE,Mail Stop D66, Atlanta, GA 30329 USA. EM vhill@cdc.gov RI Robertson, Simon/D-1549-2012; Hill, Vincent/G-1789-2012; Moe, Christine/G-6118-2012; Liu, Pengbo/J-9801-2012 OI Hill, Vincent/0000-0001-7069-7737; Liu, Pengbo/0000-0002-5269-2497 FU WaterReuse Foundation; U.S. Bureau of Reclamation (WateReuse Foundation) [WRF-04-013]; CDC Foundation FX Funding for this project was provided by the WaterReuse Foundation and U.S. Bureau of Reclamation (WateReuse Foundation Project #WRF-04-013) in partnership with the CDC Foundation. The authors acknowledge the assistance provided by Guy Pihera and the staff at the Clayton County Water Authority, and Richard Porter, Neal Spivey, Frank Stephens and the staff at the F. Wayne Hill Water Resources Center. NR 28 TC 30 Z9 30 U1 5 U2 66 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-7012 EI 1872-8359 J9 J MICROBIOL METH JI J. Microbiol. Methods PD JAN PY 2012 VL 88 IS 1 BP 155 EP 161 DI 10.1016/j.mimet.2011.11.007 PG 7 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA 888BA UT WOS:000299977600024 PM 22108496 ER PT J AU Billeter, SA Kasten, RW Killmaster, LF Breitschwerdt, EB Levin, ML Levy, MG Kosoy, MY Chomel, BB AF Billeter, Sarah A. Kasten, Rick W. Killmaster, Lindsay F. Breitschwerdt, Edward B. Levin, Michael L. Levy, Michael G. Kosoy, Michael Y. Chomel, Bruno B. TI Experimental infection by capillary tube feeding of Rhipicephalus sanguineus with Bartonella vinsonii subspecies berkhoffii SO COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES LA English DT Article DE Bartonella vinsonii subspecies berkhoffii; Rhipicephalus sanguineus; Artificial infection; Transmission ID TICK-BORNE PATHOGENS; GRANULOMATOUS-DISEASE; AMBLYOMMA-AMERICANUM; NORTHERN CALIFORNIA; EHRLICHIA-CANIS; DOMESTIC CATS; RISK-FACTORS; DOGS; HENSELAE; ENDOCARDITIS AB It has been speculated that ticks may serve as vectors of Bartonella species. Circumstantial, clinical, epidemiological and serological evidence suggest that B. vinsonii subspecies berkhoffii (B. v. berkhoffii) might be transmitted by Rhipicephalus sanguineus. The purpose of the present study was to determine whether adult R. sanguineus ticks can be infected with a B. v. berkhoffii genotype II isolate via capillary tube feeding and whether the infection can then be transmitted from adult females to their eggs via trans-ovarial transmission. Furthermore, tick fecal material was also collected and screened as a possible source of infectious inoculum for canine infections. B. v. berkhoffii DNA was detected in 50% (7 of 14) of females that did not oviposit and in 14.3% (2 of 14) of female ticks that laid eggs, but not detected in egg clutches (100 eggs/female). DNA was also detected in tick feces collected on days 2 through 6 post-capillary tube feeding, however, dogs (n = 3) did not become bacteremic or seroconvert when inoculated with tick fecal material. Therefore, trans-ovarial transmission of B. v. berkhoffii by R. sanguineus is unlikely, but further studies are needed to determine if tick fecal material can serve as a source of infection to canines. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Breitschwerdt, Edward B.; Levy, Michael G.] N Carolina State Univ, Coll Vet Med, Raleigh, NC 27607 USA. [Billeter, Sarah A.; Kosoy, Michael Y.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Bacterial Dis Branch, Ft Collins, CO USA. [Kasten, Rick W.; Chomel, Bruno B.] Univ Calif Davis, Dept Populat Hlth & Reprod, Sch Vet Med, Davis, CA 95616 USA. [Killmaster, Lindsay F.; Levin, Michael L.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Rickettsial Zoonoses Branch, Atlanta, GA USA. RP Breitschwerdt, EB (reprint author), N Carolina State Univ, Coll Vet Med, 1060 William Moore Dr, Raleigh, NC 27607 USA. EM ed_breitschwerdt@ncsu.edu FU California Lyme Disease Association (CALDA); American Society of Microbiology/Centers for Disease Control and Prevention FX This study was funded by a grant provided through the California Lyme Disease Association (CALDA). Sarah A. Billeter is supported through the American Society of Microbiology/Centers for Disease Control and Prevention Post-Doctoral Associates Program in Infectious Diseases and Public Health Microbiology. NR 39 TC 6 Z9 6 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0147-9571 J9 COMP IMMUNOL MICROB JI Comp. Immunol. Microbiol. Infect. Dis. PD JAN PY 2012 VL 35 IS 1 BP 9 EP 15 DI 10.1016/j.cimid.2011.09.004 PG 7 WC Immunology; Microbiology; Veterinary Sciences SC Immunology; Microbiology; Veterinary Sciences GA 884NM UT WOS:000299714800002 PM 22062313 ER PT J AU Schieve, LA Boulet, SL Blumberg, SJ Kogan, MD Yeargin-Allsopp, M Boyle, CA Visser, SN Rice, C AF Schieve, Laura A. Boulet, Sheree L. Blumberg, Stephen J. Kogan, Michael D. Yeargin-Allsopp, Marshalyn Boyle, Coleen A. Visser, Susanna N. Rice, Catherine TI Association between parental nativity and autism spectrum disorder among US-born non-Hispanic white and Hispanic children, 2007 National Survey of Children's Health SO DISABILITY AND HEALTH JOURNAL LA English DT Article DE Autistic disorder; Developmental disabilities; Prevalence; Population group; Race; Hispanic; Place of birth ID PERINATAL RISK-FACTORS; INFANTILE-AUTISM; DIAGNOSIS; BIRTH; AGE AB Background: Limited studies suggest the prevalence of autism spectrum disorders (ASD) varies by whether maternal and child birth country are discordant. Objective/Hypothesis: We explored associations between ASD and maternal and paternal nativity in a sample of US-born non-Hispanic white (NHW, n = 37,265) and US-born Hispanic (n = 4,690) children in the 2007 National Survey of Children's Health (NSCH). Methods: We assessed ASD prevalence within race-ethnicity and parental nativity subgroups. Prevalence ratios (aPR), comparing each group to NHW children with 2 US-born parents, were adjusted for child age, sex, and receipt of care in a medical home. Estimates were weighted to reflect US noninstitutionalized children. Standard errors were adjusted to account for the complex sample design. Results: In NHW children with 2 US-born parents, ASD prevalence was 1.19%; estimates were similar for NHW children with a foreign-born mother or father. There was a striking heterogeneity between Hispanic children with 2 US-born versus 2 foreign-born parents (ASD prevalence 2.39% versus 0.31%, p = .05). Even after adjustment, PRs comparing ASD prevalence in Hispanic versus NHW children were vastly different for Hispanic subgroups, suggesting a substantially lower prevalence for Hispanic children with both parents foreign-born (aPR 0.2, 95% confidence interval 0.1-0.5) and a higher prevalence for Hispanic children with both parents US-born (aPR 2.0 [0.8-4.6]). Conclusions: Previous studies comparing ASD prevalence between NHW and Hispanic children based on a composite Hispanic grouping without consideration of parental nativity likely missed important differences between these racial-ethnic groups. Continuing efforts toward improving early identification in Hispanic children are needed. Published by Elsevier Inc. C1 [Schieve, Laura A.; Boulet, Sheree L.; Yeargin-Allsopp, Marshalyn; Boyle, Coleen A.; Visser, Susanna N.; Rice, Catherine] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Blumberg, Stephen J.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Kogan, Michael D.] Maternal & Child Hlth Bur, US Hlth Resources & Serv Adm, Rockville, MD 20857 USA. RP Schieve, LA (reprint author), MS E-86,1600 Clifton Rd, Atlanta, GA USA. EM LSchieve@cdc.gov RI Rice, Catherine/D-6305-2016 NR 18 TC 13 Z9 13 U1 0 U2 8 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1936-6574 J9 DISABIL HEALTH J JI Brain Stimul. PD JAN PY 2012 VL 5 IS 1 BP 18 EP 25 DI 10.1016/j.dhjo.2011.09.001 PG 8 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health; Rehabilitation SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Rehabilitation GA 883CJ UT WOS:000299609900003 PM 22226294 ER PT J AU Peacock, G Lin, SC AF Peacock, Georgina Lin, Sue C. TI Enhancing early identification and coordination of intervention services for young children with autism spectrum disorders: Report from the Act Early Regional Summit Project SO DISABILITY AND HEALTH JOURNAL LA English DT Article DE Autism; Early identification AB Background: Increasing prevalence of autism spectrum disorders (ASD) and the merits of early intervention support the importance of early identification and detection. The Act Early Initiative attempts to address the states' capacity to support this process of early identification and early intervention. Objective: The Centers for Disease Control and Prevention (CDC) Health Resources and Services Administration (HRSA) collaborated with the Association of University Centers on Disabilities (AUCD) to develop strategies that will address state capacity for responding to the increasing demand for earlier identification, earlier diagnoses, and coordination of service systems for children with ASDs and other developmental disabilities (DD). Methods: Act Early regional summits were held to engage stakeholders from the early detection and intervention community including parents, state agencies, provider groups, autism and related disability organizations, and academia. The stakeholders then used the Logic Model to facilitate the teams' planning process. The Logic Model enables teams to understand the strengths and gaps within their state resources and plan specific activities to achieve concrete outcomes. Results: States identified opportunities and challenges in early identification of children with delay. One of the particular challenges identified were low income, rural and non-English speaking populations encountering more challenges than others in accessing diagnosis and early intervention services. Conclusions: The Summits are a unique model that demonstrates the importance of developing comprehensive state plans to advance the collaboration and coordination of early detection and intervention service systems for children with ASDs and related DDs from all racial, ethnic, geographical, and socioeconomic backgrounds. Published by Elsevier Inc. C1 [Peacock, Georgina] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Lin, Sue C.] Assoc Univ Ctr Disabil, Silver Spring, MD 20910 USA. RP Peacock, G (reprint author), 1600 Clifton Rd,MS E-86, Atlanta, GA USA. EM gpeacock@cdc.gov FU National Center on Birth Defects and Developmental Disabilities at the Centers for Disease Control and Prevention [U01DD000231]; Association of University Centers on Disabilities FX The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. Ms. Lin's work on the Act Early Summit initiative was supported by the National Center on Birth Defects and Developmental Disabilities at the Centers for Disease Control and Prevention through Cooperative Agreement U01DD000231 with the Association of University Centers on Disabilities. The authors have no conflicts of interest to report. NR 6 TC 2 Z9 2 U1 2 U2 17 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1936-6574 J9 DISABIL HEALTH J JI Brain Stimul. PD JAN PY 2012 VL 5 IS 1 BP 55 EP 59 DI 10.1016/j.dhjo.2011.10.001 PG 5 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health; Rehabilitation SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Rehabilitation GA 883CJ UT WOS:000299609900008 PM 22226299 ER PT J AU Gatwood, J Meltzer, MI Messonnier, M Ortega-Sanchez, IR Balkrishnan, R Prosser, LA AF Gatwood, Justin Meltzer, Martin I. Messonnier, Mark Ortega-Sanchez, Ismael R. Balkrishnan, Rajesh Prosser, Lisa A. TI Seasonal Influenza Vaccination of Healthy Working-Age Adults A Review of Economic Evaluations SO DRUGS LA English DT Review ID IMMUNIZATION PRACTICES ACIP; ADVISORY-COMMITTEE; COST-BENEFIT; RECOMMENDATIONS; IMPACT; TRIAL AB The recent impact of influenza on the working-age population of the US has led to changes in the recommendations for vaccination against seasonal influenza; however, the implications of vaccinating such a population have been debated. A review of cost-effectiveness analyses of vaccinating the working-age population of the US against seasonal influenza was conducted using articles published between January 1990 and January 2010. Studies considered for inclusion were identified using MEDLINE, EMBASE and Econlit. Reviewers worked in pairs, and each team member independently extracted relevant data using a standard abstraction form. The source and appropriateness of parameters (epidemiological data, probabilities and costs), the designs employed and the sufficiency of sensitivity analysis were considered during review. Key inputs extracted from the selected studies included influenza or influenza-like illness attack rates, outpatient visits averted, total vaccination days and lost workdays. Seven studies were identified as appropriate for this review. All studies were conducted in the US and from the societal perspective; three were randomized controlled trials and the remaining four were economic simulation models comparing vaccination and influenza antiviral drugs or no intervention; analyses focused on healthy working-age adults aged 18-49 years. Results ranged from net savings of $US68.96 to net costs of $US85.92 per person vaccinated (four studies) and net costs of $US104-1005 per episode of influenza averted (one study). Only two studies reported cost-effectiveness ratios; these ranged from $US26 565 to $US50 512 per quality-adjusted life-year gained. Nearly all of the studies conducted sensitivity analysis; results were most sensitive to variation in wage rates, levels of worker productivity, the costs and effectiveness of vaccination, and the rate of influenza illness. Review of the included studies suggests that seasonal influenza vaccination of healthy, working-age adults is generally not cost saving, requiring an investment to generate health benefits. The decision to vaccinate such a group will depend upon the societal and payer valuation of those benefits. C1 [Gatwood, Justin; Balkrishnan, Rajesh] Univ Michigan, Coll Pharm, Ann Arbor, MI 48109 USA. [Meltzer, Martin I.; Messonnier, Mark; Ortega-Sanchez, Ismael R.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Prosser, Lisa A.] Univ Michigan, Sch Med, Ann Arbor, MI 48109 USA. RP Gatwood, J (reprint author), Univ Michigan, Coll Pharm, 428 Church St, Ann Arbor, MI 48109 USA. EM gatwood@umich.edu FU Harvard-CDC Joint Initiative in Vaccine Economics FX Funding for this project was provided by the Harvard-CDC Joint Initiative in Vaccine Economics. The authors acknowledge the valuable contributions of Drs Carolyn Bridges, Guillermo Herrera, Marie Griffin and Ron Keren who reviewed the presubmission manuscript. NR 17 TC 13 Z9 14 U1 2 U2 5 PU ADIS INT LTD PI AUCKLAND PA 41 CENTORIAN DR, PRIVATE BAG 65901, MAIRANGI BAY, AUCKLAND 1311, NEW ZEALAND SN 0012-6667 J9 DRUGS JI Drugs PY 2012 VL 72 IS 1 BP 35 EP 48 PG 14 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 878GG UT WOS:000299242900003 PM 22191794 ER PT J AU Brooks, DR Avetisyan, R Jarrett, KM Hanchate, A Shapiro, GD Pugh, MJ Berlowitz, DR Thurman, D Montouris, G Kazis, LE AF Brooks, Daniel R. Avetisyan, Ruzan Jarrett, Kelli M. Hanchate, Amresh Shapiro, G. D. Pugh, M. J. Berlowitz, Dan R. Thurman, David Montouris, Georgia Kazis, Lewis E. TI Validation of self-reported epilepsy for purposes of community surveillance SO EPILEPSY & BEHAVIOR LA English DT Article DE Epilepsy; Seizure disorder; Questionnaires; Validity; Surveillance; Self-report ID SOUTH-CAROLINA; HEALTH-STATUS; PREVALENCE; ADULTS; CARE; SYSTEM; POPULATION; SEIZURES; GEORGIA AB We evaluated the validity of questions designed to identify lifetime and active epilepsy, medication use, and seizure occurrence on population-based surveys. Subjects were interviewed by telephone, and responses were compared with information in their medical records. Prevalence, sensitivity, specificity, and positive predictive value (PPV) were calculated. The prevalence of ever having been diagnosed with epilepsy was 3.1% by self-report and 2.7% by medical record review. Sensitivity was 84.2%, specificity was 99.2%, and PPV was 73.5% for self-reported lifetime epilepsy, and values were similar for active epilepsy. By comparison, sensitivity was higher and specificity was lower for epilepsy medication use and seizure occurrence. The PPV for seizure occurrence was substantially higher for a recall period of 12 months than for 3 months. These results compare favorably with results for other chronic conditions, such as diabetes and arthritis, and indicate that questionnaires can be used to identify epilepsy at a population level. (C) 2011 Elsevier Inc. All rights reserved. C1 [Avetisyan, Ruzan; Jarrett, Kelli M.; Shapiro, G. D.; Berlowitz, Dan R.; Kazis, Lewis E.] Boston Univ, Sch Publ Hlth, CAPP, Dept Hlth Policy & Management, Boston, MA 02118 USA. [Brooks, Daniel R.] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02118 USA. [Hanchate, Amresh] Boston Univ, Sch Med, Gen Internal Med Sect, Boston, MA 02118 USA. [Pugh, M. J.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med Geriatr & Gerontol, San Antonio, TX 78229 USA. [Thurman, David] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Montouris, Georgia] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA. RP Kazis, LE (reprint author), Boston Univ, Sch Publ Hlth, CAPP, Dept Hlth Policy & Management, Boston, MA 02118 USA. EM lek@bu.edu OI Hanchate, Amresh/0000-0002-7038-4463; Kazis, Lewis/0000-0003-1800-5849; Brooks, Daniel/0000-0001-6220-6889 FU Centers for Disease Control and Prevention [5 U48 DP00058] FX This publication was supported by Cooperative Agreement 5 U48 DP00058 from the Centers for Disease Control and Prevention. The findings and conclusions are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 26 TC 18 Z9 19 U1 1 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1525-5050 J9 EPILEPSY BEHAV JI Epilepsy Behav. PD JAN PY 2012 VL 23 IS 1 BP 57 EP 63 DI 10.1016/j.yebeh.2011.11.002 PG 7 WC Behavioral Sciences; Clinical Neurology; Psychiatry SC Behavioral Sciences; Neurosciences & Neurology; Psychiatry GA 883XO UT WOS:000299668400011 PM 22189155 ER PT J AU Barile, JP Kuperminc, GP Weintraub, ES Mink, JW Thompson, WW AF Barile, John P. Kuperminc, Gabriel P. Weintraub, Eric S. Mink, Jonathan W. Thompson, William W. TI Thimerosal Exposure in Early Life and Neuropsychological Outcomes 7-10 Years Later SO JOURNAL OF PEDIATRIC PSYCHOLOGY LA English DT Article DE children; modeling; neuropsychology; public health; structural equation ID VACCINE SAFETY DATALINK; COMORBIDITIES A-TAC; GOODNESS-OF-FIT; TELEPHONE INTERVIEW; AUTISM-TICS; METHYLMERCURY EXPOSURE; COVARIANCE-STRUCTURES; TOURETTE-SYNDROME; CHILDREN; INDEXES AB Objective The authors used a public use data set to investigate associations between the receipt of thimerosal-containing vaccines and immune globulins early in life and neuropsychological outcomes assessed at 7-10 years. Methods The data were originally created by evaluating 1,047 children ages 7-10 years and their biological mothers. This study developed seven latent neuropsychological factors and regressed them on a comprehensive set of covariates and thimerosal exposure variables. Results The authors found no statistically significant associations between thimerosal exposure from vaccines early in life and six of the seven latent constructs. There was a small, but statistically significant association between early thimerosal exposure and the presence of tics in boys. Conclusions This finding should be interpreted with caution due to limitations in the measurement of tics and the limited biological plausibility regarding a causal relationship. C1 [Barile, John P.; Thompson, William W.] US Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30331 USA. [Barile, John P.; Kuperminc, Gabriel P.] Georgia State Univ, Dept Psychol, Atlanta, GA 30303 USA. [Weintraub, Eric S.] US Ctr Dis Control & Prevent, Immunizat Safety Off, Atlanta, GA 30331 USA. [Mink, Jonathan W.] Univ Rochester, Med Ctr, Rochester, NY 14627 USA. RP Barile, JP (reprint author), US Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,Mailstop K51, Atlanta, GA 30331 USA. EM jbarile@cdc.gov NR 59 TC 15 Z9 16 U1 1 U2 18 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0146-8693 J9 J PEDIATR PSYCHOL JI J. Pediatr. Psychol. PD JAN-FEB PY 2012 VL 37 IS 1 BP 106 EP 118 DI 10.1093/jpepsy/jsr048 PG 13 WC Psychology, Developmental SC Psychology GA 885NT UT WOS:000299786400011 PM 21785120 ER PT J AU Kohl, HW Hootman, JM AF Kohl, Harold W., III Hootman, Jennifer M. TI Reflections Before Moving Forward SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH LA English DT Editorial Material C1 [Kohl, Harold W., III] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA. [Hootman, Jennifer M.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Kohl, HW (reprint author), Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA. FU Intramural CDC HHS [CC999999] NR 0 TC 1 Z9 1 U1 0 U2 0 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1543-3080 J9 J PHYS ACT HEALTH JI J. Phys. Act. Health PD JAN PY 2012 VL 9 IS 1 BP 1 EP 2 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 885SW UT WOS:000299802100001 PM 22332250 ER PT J AU Ainsworth, BE Caspersen, CJ Matthews, CE Masse, LC Baranowski, T Zhu, WM AF Ainsworth, Barbara E. Caspersen, Carl J. Matthews, Charles E. Masse, Louise C. Baranowski, Tom Zhu, Weimo TI Recommendations to Improve the Accuracy of Estimates of Physical Activity Derived From Self Report SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH LA English DT Article DE survey; questionnaire; measurement error ID OLDER-ADULTS; ACTIVITY QUESTIONNAIRE; MEASUREMENT ERROR; UNITED-STATES; WOMEN; ACCELEROMETER; INTERVENTIONS; VALIDATION; COMPENDIUM; MEN AB Context: Assessment of physical activity using self-report has the potential for measurement error that can lead to incorrect inferences about physical activity behaviors and bias study results. Objective: To provide recommendations to improve the accuracy of physical activity derived from self report. Process: We provide an overview of presentations and a compilation of perspectives shared by the authors of this paper and workgroup members. Findings: We identified a conceptual framework for reducing errors using physical activity self-report questionnaires. The framework identifies 6 steps to reduce error: 1) identifying the need to measure physical activity, 2) selecting an instrument, 3) collecting data, 4) analyzing data, 5) developing a summary score, and 6) interpreting data. Underlying the first 4 steps are behavioral parameters of type, intensity, frequency, and duration of physical activities performed, activity domains, and the location where activities are performed. We identified ways to reduce measurement error at each step and made recommendations for practitioners, researchers, and organizational units to reduce error in questionnaire assessment of physical activity. Conclusions: Self-report measures of physical activity have a prominent role in research and practice settings. Measurement error may be reduced by applying the framework discussed in this paper. C1 [Ainsworth, Barbara E.] Arizona State Univ, Program Exercise & Wellness, Sch Nutr & Hlth Promot, Phoenix, AZ 85069 USA. [Caspersen, Carl J.] Ctr Dis Control & Prevent, Epidemiol & Stat Branch, Div Diabet Translat, Atlanta, GA USA. [Matthews, Charles E.] NCI, Nutr Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Masse, Louise C.] Univ British Columbia, Dept Pediat, Sch Populat & Publ Hlth, Vancouver, BC V6T 1W5, Canada. [Baranowski, Tom] Baylor Coll Med, Dept Pediat, Childrens Nutr Res Ctr, Houston, TX 77030 USA. [Zhu, Weimo] Univ Illinois, Dept Kinesiol & Community Hlth, Coll Appl Hlth Sci, Urbana, IL 61801 USA. RP Ainsworth, BE (reprint author), Arizona State Univ, Program Exercise & Wellness, Sch Nutr & Hlth Promot, Phoenix, AZ 85069 USA. RI Caspersen, Carl/B-2494-2009; matthews, Charles/E-8073-2015 OI matthews, Charles/0000-0001-8037-3103 FU Intramural NIH HHS [Z99 CA999999] NR 38 TC 48 Z9 49 U1 8 U2 26 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1543-3080 J9 J PHYS ACT HEALTH JI J. Phys. Act. Health PD JAN PY 2012 VL 9 SU 1 BP S76 EP S84 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 885FR UT WOS:000299764400010 PM 22287451 ER PT J AU Hooker, SP Fulton, J Mudd, LM AF Hooker, Steven P. Fulton, Janet Mudd, Lanay M. TI Practice-Based Evidence: A Novel Concept for Self-Report Physical Activity Measurement SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH LA English DT Editorial Material ID PUBLIC-HEALTH; SCIENCE C1 [Hooker, Steven P.] Univ S Carolina, Prevent Res Ctr, Columbia, SC 29208 USA. [Fulton, Janet] Ctr Dis Control & Prevent, Div Nutr & Phys Act, Atlanta, GA USA. [Mudd, Lanay M.] Appalachian State Univ, Dept Hlth Leisure & Exercise Sci, Boone, NC 28608 USA. RP Hooker, SP (reprint author), Univ S Carolina, Prevent Res Ctr, Columbia, SC 29208 USA. NR 10 TC 2 Z9 2 U1 0 U2 0 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1543-3080 J9 J PHYS ACT HEALTH JI J. Phys. Act. Health PD JAN PY 2012 VL 9 SU 1 BP S85 EP S87 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 885FR UT WOS:000299764400011 PM 22287452 ER PT J AU Dolan, SM Cox, S Tepper, N Ruddy, D Rasmussen, SA MacFarlane, K AF Dolan, Siobhan M. Cox, Shanna Tepper, Naomi Ruddy, Deborah Rasmussen, Sonja A. MacFarlane, Kitty TI Pharmacists' knowledge, attitudes, and practices regarding influenza vaccination and treatment of pregnant women SO JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION LA English DT Article DE Influenza; H1N1 influenza; vaccinations; pregnancy ID A H1N1 VIRUS; UNITED-STATES; PANDEMIC INFLUENZA; IMMUNIZATION; SAFETY; CARE; VACCINES; ILLNESS; IMPACT AB Objectives: To understand pharmacists' knowledge, attitudes, and practices regarding vaccination and treatment of pregnant women for seasonal influenza and pandemic 2009 influenza A (H1N1). Design: Descriptive, exploratory, nonexperimental study. Setting: United States between January 21, 2010, and February 9, 2010. Participants: 606 pharmacists who participated in the American Pharmacists Association (APhA) Immunization Certificate Training Program and practice in chain, supermarket, mass merchandise, and independent pharmacies. Intervention: Electronic survey sent by APhA to 7,356 pharmacists who had participated in its Immunization Certificate Training Program. Main outcome measures: Pharmacists' knowledge, attitudes, and practices regarding vaccination and antiviral treatment of pregnant women for seasonal and H1N1 influenza. Results: Respondents were more likely to recognize that pregnant women are at an increased risk associated with H1N1 influenza (85%) than to recognize the increased risk associated with seasonal influenza (78%). However, respondents were less likely to believe that they have an important role in vaccinating pregnant women compared with the general public (82% vs. 97%) and less likely to agree that 2009 H1N1 vaccine was safe during pregnancy compared with the seasonal influenza vaccine (78% vs. 87%). Pharmacists who had been vaccinated themselves were more likely to recommend vaccination for pregnant patients. Only 38% believed that antiviral medications such as oseltamivir can be given during pregnancy because the benefits outweigh the risks. However, in response to case studies of pregnant women who were candidates for antiviral medications, respondents indicated that they would take extraordinary steps to ensure that pregnant women were either referred for medical assessment or for assistance in obtaining prescribed antiviral medications. Conclusion: Education efforts that focus on the effectiveness and safety of influenza vaccination during pregnancy and the benefits of treating pregnant women with confirmed or suspected influenza with antiviral medications may be useful in improving pharmacists' support of pharmaceutical interventions to reduce the impact of influenza in pregnant women. Pharmacists' personal decisions regarding vaccination may be a marker for their overall assessment of risks and benefits and may influence their recommendations for pregnant patients. C1 [Dolan, Siobhan M.] Montefiore Med Ctr, Albert Einstein Coll Med, Bronx, NY 10461 USA. [Cox, Shanna] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Ruddy, Deborah] Amer Pharmacists Assoc, Washington, DC USA. [Rasmussen, Sonja A.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [MacFarlane, Kitty] Ctr Dis Control & Prevent, Maternal Hlth Team, WHO Coordinating Ctr Reprod Hlth, Div Reprod Hlth,Natl Ctr Chron Dis Prevent & Hlth, Atlanta, GA USA. RP Dolan, SM (reprint author), Montefiore Med Ctr, Albert Einstein Coll Med, Mazer 634,1300 Morris Pk Ave, Bronx, NY 10461 USA. EM siobhanmdolan@yahoo.com FU Centers for Disease Control and Prevention FX Centers for Disease Control and Prevention. NR 44 TC 2 Z9 2 U1 0 U2 1 PU AMER PHARMACEUTICAL ASSOC PI WASHINGTON PA 2215 CONSTITUTION AVE NW, WASHINGTON, DC 20037 USA SN 1544-3191 J9 J AM PHARM ASSOC JI J. Am. Pharm. Assoc. PD JAN-FEB PY 2012 VL 52 IS 1 BP 43 EP 51 DI 10.1331/JAPhA.2012.10141 PG 9 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 881WV UT WOS:000299523100007 PM 22257615 ER PT J AU Glasser, J Feng, ZL Moylan, A Del Valle, S Castillo-Chavez, C AF Glasser, John Feng, Zhilan Moylan, Andrew Del Valle, Sara Castillo-Chavez, Carlos TI Mixing in age-structured population models of infectious diseases SO MATHEMATICAL BIOSCIENCES LA English DT Article DE Interpersonal contacts; Preferential mixing; Transmission modeling; Intervention assessment; Indirect effects ID TRANSMISSION PARAMETERS; INFLUENZA; SPREAD; HOUSEHOLD; NETWORKS; PATTERNS; MEASLES AB Infectious diseases are controlled by reducing pathogen replication within or transmission between hosts. Models can reliably evaluate alternative strategies for curtailing transmission, but only if interpersonal mixing is represented realistically. Compartmental modelers commonly use convex combinations of contacts within and among groups of similarly aged individuals, respectively termed preferential and proportionate mixing. Recently published face-to-face conversation and time-use studies suggest that parents and children and co-workers also mix preferentially. As indirect effects arise from the off-diagonal elements of mixing matrices, these observations are exceedingly important. Accordingly, we refined the formula published by Jacquez et al. [19] to account for these newly-observed patterns and estimated age-specific fractions of contacts with each preferred group. As the ages of contemporaries need not be identical nor those of parents and children to differ by exactly the generation time, we also estimated the variances of the Gaussian distributions with which we replaced the Kronecker delta commonly used in theoretical studies. Our formulae reproduce observed patterns and can be used, given contacts, to estimate probabilities of infection on contact, infection rates, and reproduction numbers. As examples, we illustrate these calculations for influenza based on "attack rates" from a prospective household study during the 1957 pandemic and for varicella based on cumulative incidence estimated from a cross-sectional serological survey conducted from 1988-94, together with contact rates from the several face-to-face conversation and time-use studies. Susceptibility to infection on contact generally declines with age, but may be elevated among adolescents and adults with young children. Published by Elsevier Inc. C1 [Glasser, John] Ctr Dis Control & Prevent, Atlanta, GA USA. [Feng, Zhilan] Purdue Univ, W Lafayette, IN 47907 USA. [Moylan, Andrew] Wolfram Res, Champaign, IL USA. [Del Valle, Sara] Los Alamos Natl Lab, Los Alamos, NM USA. [Castillo-Chavez, Carlos] Arizona State Univ, Tempe, AZ USA. [Castillo-Chavez, Carlos] Santa Fe Inst, Santa Fe, NM 87501 USA. [Castillo-Chavez, Carlos] Cornell Univ, Ithaca, NY USA. RP Glasser, J (reprint author), 1600 Clifton Rd NE,Mail Stop A-34, Atlanta, GA 30333 USA. EM jglasser@cdc.gov RI Castillo-Chavez, Carlos/E-1412-2014 OI Castillo-Chavez, Carlos/0000-0002-1046-3901 FU CDC [IPA908630]; Purdue University; NSF [DMS-1022758] FX We are grateful to Roger Germundsson for guiding J.G. during the 2009 Advanced Mathematica (TM) Summer School, Karl Hadeler for helpful discussions, two anonymous reviewers for constructive suggestions, and Nathaniel Hupert and Michael Washington for support. Recognizing the importance of mixing in population modeling, John Edmunds pioneered empirical studies of inter-personal contacts, several of which permitted this theoretical study and applications. Z.F.'s research is partially supported by IPA908630 between the CDC and Purdue University and NSF grant DMS-1022758. NR 31 TC 10 Z9 11 U1 2 U2 20 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0025-5564 J9 MATH BIOSCI JI Math. Biosci. PD JAN PY 2012 VL 235 IS 1 BP 1 EP 7 DI 10.1016/j.mbs.2011.10.001 PG 7 WC Biology; Mathematical & Computational Biology SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational Biology GA 885EM UT WOS:000299761300001 PM 22037144 ER PT J AU Ayinmode, AB Fagbemi, BO Xiao, LH AF Ayinmode, Adekunle Bamidele Fagbemi, Benjamin Olakunle Xiao, Lihua TI Molecular characterization of Cryptosporidium in children in Oyo State, Nigeria: implications for infection sources SO PARASITOLOGY RESEARCH LA English DT Article ID SUBTYPES AB A study was conducted to detect and identify Cryptosporidium spp. in 43 children from Oyo State, Nigeria. Using nested polymerase chain reaction, 11.6% of the children were identified as positive for Cryptosporidium spp. Restriction fragment length polymorphism analysis and DNA sequencing of the PCR products showed the presence of three subtype families of Cryptosporidium hominis (two isolates of Ia and one isolate of Ib) and Cryptosporidium parvum (two isolates of IIc), all anthroponotic in nature. This study identified a high diversity of Cryptosporidium subtypes and clearly suggested that anthroponotic rather than zoonotic transmission played a more important role in the epidemiology of Cryptosporidium in the studied area. C1 [Ayinmode, Adekunle Bamidele; Xiao, Lihua] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA. [Ayinmode, Adekunle Bamidele; Fagbemi, Benjamin Olakunle] Univ Ibadan, Fac Vet Med, Dept Vet Microbiol & Parasitol, Ibadan, Nigeria. RP Ayinmode, AB (reprint author), Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA. EM ayins2000@yahoo.com RI Xiao, Lihua/B-1704-2013 OI Xiao, Lihua/0000-0001-8532-2727 FU University of Ibadan (Nigeria); Centers for Disease Control and Prevention, Atlanta, GA, USA FX This work was supported by the John D. and Catherine T. MacArthur Foundation Overseas Training Grant from the University of Ibadan (Nigeria) and the Centers for Disease Control and Prevention, Atlanta, GA, USA. We thank Theresa Dearen for technical assistance. This study received approval from the University of Ibadan/University College Hospital Ethics Committee with the assigned number UI/EC/10/0129. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 8 TC 7 Z9 7 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0932-0113 J9 PARASITOL RES JI Parasitol. Res. PD JAN PY 2012 VL 110 IS 1 BP 479 EP 481 DI 10.1007/s00436-011-2531-0 PG 3 WC Parasitology SC Parasitology GA 881WE UT WOS:000299521000058 PM 21744017 ER PT J AU Nelson, JC Cook, AJ Yu, O Dominguez, C Zhao, SS Greene, SK Fireman, BH Jacobsen, SJ Weintraub, ES Jackson, LA AF Nelson, Jennifer C. Cook, Andrea J. Yu, Onchee Dominguez, Clara Zhao, Shanshan Greene, Sharon K. Fireman, Bruce H. Jacobsen, Steven J. Weintraub, Eric S. Jackson, Lisa A. TI Challenges in the design and analysis of sequentially monitored postmarket safety surveillance evaluations using electronic observational health care data SO PHARMACOEPIDEMIOLOGY AND DRUG SAFETY LA English DT Article DE observational study; pharmacovigilance; postmarketing; sequential testing; study design; vaccine and drug safety ID INFLUENZA VACCINE SAFETY; REAL-TIME SURVEILLANCE; CLINICAL-TRIALS; ADVERSE EVENTS; ACTIVE SURVEILLANCE; BOUNDARIES; PENTAVALENT; NETWORKS; PROJECT; SYSTEM AB Purpose Many challenges arise when conducting a sequentially monitored medical product safety surveillance evaluation using observational electronic data captured during routine care. We review existing sequential approaches for potential use in this setting, including a continuous sequential testing method that has been utilized within the Vaccine Safety Datalink (VSD) and group sequential methods, which are used widely in randomized clinical trials. Methods Using both simulated data and preliminary data from an ongoing VSD evaluation, we discuss key sequential design considerations, including sample size and duration of surveillance, shape of the signaling threshold, and frequency of interim testing. Results and Conclusions All designs control the overall Type 1 error rate across all tests performed, but each yields different tradeoffs between the probability and timing of true and false positive signals. Designs tailored to monitor efficacy outcomes in clinical trials have been well studied, but less consideration has been given to optimizing design choices for observational safety settings, where the hypotheses, population, prevalence and severity of the outcomes, implications of signaling, and costs of false positive and negative findings are very different. Analytic challenges include confounding, missing and partially accrued data, high misclassification rates for outcomes presumptively defined using diagnostic codes, and unpredictable changes in dynamically accessed data over time (e. g., differential product uptake). Many of these factors influence the variability of the adverse events under evaluation and, in turn, the probability of committing a Type 1 error. Thus, to ensure proper Type 1 error control, planned sequential thresholds should be adjusted over time to account for these issues. Copyright (C) 2012 John Wiley & Sons, Ltd. C1 [Nelson, Jennifer C.; Cook, Andrea J.; Yu, Onchee; Dominguez, Clara] Grp Hlth Res Inst, Biostat Unit, Seattle, WA 98101 USA. [Nelson, Jennifer C.; Cook, Andrea J.; Dominguez, Clara; Zhao, Shanshan] Univ Washington, Dept Biostat, Seattle, WA 98195 USA. [Greene, Sharon K.] Harvard Univ, Dept Populat Med, Sch Med, Boston, MA USA. [Greene, Sharon K.] Harvard Pilgrim Hlth Care Inst, Boston, MA USA. [Fireman, Bruce H.] Kaiser Permanente Div Res, Oakland, CA USA. [Jacobsen, Steven J.] Kaiser Permanente So Calif, Dept Res & Evaluat, Pasadena, CA USA. [Weintraub, Eric S.] Ctr Dis Control & Prevent, Immunizat Safety Off, Atlanta, GA USA. RP Nelson, JC (reprint author), Grp Hlth Res Inst, Biostat Unit, 1730 Minor Ave,Suite 1600, Seattle, WA 98101 USA. EM nelson.jl@ghc.org OI Jacobsen, Steven/0000-0002-8174-8533 FU CDC [200-2002-00732]; FDA through the Department of Health and Human Services [HHSF223200910006I] FX This work was funded in part through a VSD subcontract with America's Health Insurance Plans under Contract 200-2002-00732 from the CDC and a Mini-Sentinel subcontract. Mini-Sentinel is funded by the FDA through the Department of Health and Human Services Contract Number HHSF223200910006I. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the CDC or FDA. NR 32 TC 18 Z9 18 U1 1 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1053-8569 EI 1099-1557 J9 PHARMACOEPIDEM DR S JI Pharmacoepidemiol. Drug Saf. PD JAN PY 2012 VL 21 SU 1 BP 62 EP 71 DI 10.1002/pds.2324 PG 10 WC Public, Environmental & Occupational Health; Pharmacology & Pharmacy SC Public, Environmental & Occupational Health; Pharmacology & Pharmacy GA 878JU UT WOS:000299253900009 PM 22262594 ER PT J AU Shen, JN Oraka, E AF Shen, Joannie Oraka, Erneka TI Complementary and alternative medicine (CAM) use among children with current asthma SO PREVENTIVE MEDICINE LA English DT Article DE Asthma; Children; Complementary and alternative medicine; BRFSS; Asthma Callback Survey ID THERAPY USE; MANAGEMENT; BUTEYKO; TRIAL; CARE AB Objective. To estimate the prevalence of complementary and alternative medicine (CAM) use among children with current asthma. Design. We analyzed data from the Asthma Call Back Survey (ACBS) 2006-2008. ACBS is a follow-up to the state-based Behavioral Risk Factor Surveillance System (BRFSS) survey that collects information on asthma and related factors including CAM use for asthma. The survey is administered to the parents who report in a subset of BRFSS states that their children have asthma. 5435 children had current asthma and were included in this analysis. Results. Overall, 26.7% (95% confidence interval [Cl] = 24.5-29.0) of children with current asthma reported CAM use in the previous 12 months. Among them, the three most commonly used therapies were breathing techniques (58.5%; 95% CI = 53.6-63.5), vitamins (27.3%; 95% CI = 23.0-31.5), and herbal products (12.8%; 95% Cl = 9.2-16.4). Multivariate analysis of CAM use revealed higher adjusted odds ratios (aOR) among children who experienced cost barriers to conventional health care compared with children with no cost barrier (aOR = 1.8; 95% CI = 1.2-2.8). Children with poorly controlled asthma were most likely to use all types of CAM when compared to their counterpart with well-controlled asthma: aOR = 2.3 (95% CI = 1.6-3.3) for any CAM; aOR = 1.7 (95% Cl = 1.2-2.6) for self-care based CAM; and aOR = 4.4 (95% Cl = 1.6-9.3) for practitioner-based CAM. Conclusions. Children with poorly controlled asthma are more likely to use CAM; this likelihood persists after controlling for other factors (including parent's education, barriers to conventional health care, and controller medication use). CAM is also more commonly used by children who experienced cost barriers to conventional asthma care. CAM use could be a marker to identify patients who need patient/family education and support thus facilitate improved asthma control. (C) 2011 Published by Elsevier Inc. C1 [Shen, Joannie] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Environm Hazards & Hlth Effects, Air Pollut & Resp Hlth Branch, Atlanta, GA 30341 USA. Ctr Dis Control & Prevent, Behav & Clin Surveillance Branch, ICF Int Natl Ctr HIVAIDS Viral Hepatitis STD & TB, Atlanta, GA 30341 USA. RP Shen, JN (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Environm Hazards & Hlth Effects, Air Pollut & Resp Hlth Branch, 4770 Buford Highway,MSF 58, Atlanta, GA 30341 USA. EM GMQ6@cdc.gov NR 20 TC 30 Z9 30 U1 1 U2 13 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0091-7435 J9 PREV MED JI Prev. Med. PD JAN 1 PY 2012 VL 54 IS 1 BP 27 EP 31 DI 10.1016/j.ypmed.2011.10.007 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 881BM UT WOS:000299455500008 PM 22015560 ER PT J AU Richardson, LC Neri, AJ Tai, E Glenn, JD AF Richardson, Lisa C. Neri, Antonio J. Tai, Eric Glenn, Jeffrey D. TI Testicular cancer: A narrative review of the role of socioeconomic position from risk to survivorship SO UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS LA English DT Article DE Testicular cancer; Socioeconomic status; Socioeconomic position; Occupation; Income; Education ID GERM-CELL TUMORS; LONG-TERM SURVIVORS; UNITED-STATES; SOCIAL-CLASS; HEALTH RESEARCH; BIRTH-ORDER; MEN; OCCUPATION; EPIDEMIOLOGY; DIAGNOSIS AB Background: Testicular cancer (TC) is one of the most curable cancers. Given survival rates of close to 100% with appropriate therapy, ensuring proper treatment is essential. We reviewed and summarized the literature on the association of socioeconomic position (SEP) along the cancer control spectrum from risk factors to survivorship. Methods: We searched PubMed from 1966 to 2011 using the following terms: testicular cancer, testicular neoplasm, poverty, and socioeconomic factors, retrieving 119 papers. After excluding papers for the non-English (10) language and non-relevance (46), we reviewed 63 papers. We abstracted information on socioeconomic position (SEP), including occupation, education, income, and combinations of the 3. Five areas were examined: risk factors, diagnosis, treatment, survival, and survivorship. Results: Most studies examined area-based measures, not individual measures of SEP. The majority of studies found an increased risk of developing TC with high SEP though recent papers have indicated increased risk in low-income populations. Regarding diagnosis, recent papers have indicated that lower levels of education and SEP are risk factors for later-stage TC diagnosis and hence higher TC mortality. For treatment, 1 study that examined the use of radiation therapy (RT) in stage I seminoma reported that living in a county with lower educational attainment led to lower use of RT. For survival (mortality), several studies found that men living in lower SEP geographic areas experience lower survival and higher mortality. Conclusion: The strongest evidence for SEP impact on testicular germ cell tumor (TGCT) was found for the risk of developing cancer as well as survival. The association of SEP with TGCT risk appears to have changed over the last decade. Given the highly curable nature of TGCT, more research is needed to understand how SEP impacts diagnosis and treatment for TGCT and to design interventions to address disparities in TGCT outcomes and SEP. Published by Elsevier Inc. C1 [Richardson, Lisa C.; Neri, Antonio J.; Tai, Eric; Glenn, Jeffrey D.] Ctr Dis Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Canc Prevent & Control, Atlanta, GA 30341 USA. RP Richardson, LC (reprint author), Ctr Dis Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Canc Prevent & Control, Atlanta, GA 30341 USA. EM lrichardson@cdc.gov FU Intramural CDC HHS [CC999999] NR 80 TC 6 Z9 7 U1 0 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1078-1439 EI 1873-2496 J9 UROL ONCOL-SEMIN ORI JI Urol. Oncol.-Semin. Orig. Investig. PD JAN-FEB PY 2012 VL 30 IS 1 BP 95 EP 101 DI 10.1016/j.urolonc.2011.09.010 PG 7 WC Oncology; Urology & Nephrology SC Oncology; Urology & Nephrology GA 883BN UT WOS:000299607700017 PM 22127018 ER PT J AU Agopian, AJ Canfield, MA Olney, RS Lupo, PJ Ramadhani, T Mitchell, LE Shaw, GM Moore, CA AF Agopian, A. J. Canfield, Mark A. Olney, Richard S. Lupo, Philip J. Ramadhani, Tunu Mitchell, Laura E. Shaw, Gary M. Moore, Cynthia A. TI Spina Bifida Subtypes and Sub-Phenotypes by Maternal Race/Ethnicity in the National Birth Defects Prevention Study SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A LA English DT Article DE spina bifida; neural tube defects; myelomeningocele; meningocele; myelocele; congenital abnormalities; descriptive epidemiology; Hispanic Americans; African Americans; sex ID NEURAL-TUBE DEFECTS; FOLIC-ACID FORTIFICATION; CALIFORNIA BIRTHS; UNITED-STATES; PREVALENCE; LIPOMYELOMENINGOCELE; CANADA; TEXAS AB Spina bifida refers to a collection of neural tube defects, including myelomeningocele, meningocele, and myelocele (SBM), as well as lipomyelomeningocele and lipomeningocele (SBL). Maternal race/ ethnicity has been associated with an increased risk for spina bifida among offspring. To better understand this relationship, we evaluated different spina bifida subtypes (SBM vs. SBL) and sub- phenotypes (anatomic level or presence of additional malformations) by maternal race/ ethnicity using data from the National Birth Defects Prevention Study. This study is a large, multisite, populationbased study of nonsyndromic birth defects. Prevalence estimates were obtained using data from spina bifida cases (live births, fetal deaths, and elective terminations) and total live births in the study regions. From October 1997 through December 2005, 1,046 infants/ fetuses with spina bifida were delivered, yielding a prevalence of 3.06 per 10,000 live births. Differences in the prevalences of SBM vs. SBL, isolated versus non-isolated SBM, and lesion level in isolated SBM among case offspring were observed by maternal race/ ethnicity. Compared to non-Hispanic (NH) White mothers, offspring of Hispanic mothers had higher prevalences of each subtype and most sub-phenotypes, while offspring of NH Black mothers generally had lower prevalences. Furthermore, differences in race/ ethnicity among those with isolated SBM were more pronounced by sex. For instance, among male offspring, the prevalence of isolated SBM was significantly higher for those with Hispanic mothers compared to NH White mothers [ prevalence ratio (PR): 1.55, 95% confidence interval: 1.23-1.95]. These findings provide evidence that certain spina bifida subtypes and sub-phenotypes may be etiologically distinct. (C) 2011 Wiley Periodicals, Inc. C1 [Canfield, Mark A.; Ramadhani, Tunu] Texas Dept State Hlth Serv, Birth Defects Epidemiol & Surveillance Branch, Austin, TX USA. [Agopian, A. J.; Lupo, Philip J.; Mitchell, Laura E.] Univ Texas Sch Publ Hlth, Div Epidemiol Human Genet & Environm Sci, Houston, TX USA. [Agopian, A. J.; Lupo, Philip J.; Mitchell, Laura E.] Univ Texas Sch Publ Hlth, Ctr Human Genet, Houston, TX USA. [Olney, Richard S.; Moore, Cynthia A.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Shaw, Gary M.] Stanford Univ, Sch Med, Div Neonatal & Dev Med, Dept Pediat, Palo Alto, CA 94304 USA. RP Canfield, MA (reprint author), Texas Dept State Hlth Serv, Birth Defects Epidemiol & Surveillance Branch, POB 149347,MC 1964, Austin, TX USA. EM mark.canfield@dshs.state.tx.us OI Lupo, Philip/0000-0003-0978-5863 NR 25 TC 11 Z9 11 U1 0 U2 9 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1552-4825 J9 AM J MED GENET A JI Am. J. Med. Genet. A PD JAN PY 2012 VL 158A IS 1 BP 109 EP 115 DI 10.1002/ajmg.a.34383 PG 7 WC Genetics & Heredity SC Genetics & Heredity GA 880CJ UT WOS:000299381800016 PM 22140002 ER PT J AU Jackson, JM Crider, KS Rasmussen, SA Cragan, JD Olney, RS AF Jackson, Jodi M. Crider, Krista S. Rasmussen, Sonja A. Cragan, Janet D. Olney, Richard S. TI Trends in Cytogenetic Testing and Identification of Chromosomal Abnormalities among Pregnancies and Children with Birth Defects, Metropolitan Atlanta, 1968-2005 SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A LA English DT Article DE cytogenetics; chromosomal abnormality; congenital defect; prenatal; postnatal ID 22Q11 DELETION; PRENATAL-DIAGNOSIS; TETRALOGY; FALLOT; POPULATION; AMNIOCENTESIS; ATRESIA; WOMEN AB The purpose of this study was to examine changes in the use of cytogenetic testing and identification of chromosomal abnormalities among pregnancies and children with birth defects. Utilizing data from 1968 to 2005 from the Metropolitan Atlanta Congenital Defects Program, we analyzed trends in the frequency and timing (prenatal or postnatal) of cytogenetic testing and the prevalence of recognized chromosome abnormalities among pregnancies and children with birth defects (n = 51,424). Cytogenetic testing of pregnancies and children with birth defects increased from 7.2% in 1968 to 25.0% in 2005, as did the identification of chromosomal abnormalities (2.2% in 1968 to 6.8% in 2005). The use of prenatal cytogenetic testing decreased from 1996 to 2005 among women aged >= 35 years. Identification of chromosomal abnormalities in pregnancies and children with birth defects increased from 1968 to 2005, possibly due to increased testing, improved diagnostic techniques, or increasing maternal age. The decline in prenatal cytogenetic testing observed among mothers aged >= 35 years may be related to the availability of improved prenatal screening techniques, resulting in a reduction in the utilization of invasive diagnostic tests. Published 2011. This article is a U.S. Government work and is in the public domain in the USA. C1 [Jackson, Jodi M.; Crider, Krista S.; Rasmussen, Sonja A.; Cragan, Janet D.; Olney, Richard S.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. RP Jackson, JM (reprint author), 1600 Clifton Rd,MS E-86, Atlanta, GA 30333 USA. EM hwi4@cdc.gov NR 33 TC 1 Z9 1 U1 0 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1552-4825 J9 AM J MED GENET A JI Am. J. Med. Genet. A PD JAN PY 2012 VL 158A IS 1 BP 116 EP 123 DI 10.1002/ajmg.a.34385 PG 8 WC Genetics & Heredity SC Genetics & Heredity GA 880CJ UT WOS:000299381800017 PM 22140020 ER PT J AU Brouwer, D Berges, M Virji, MA Fransman, W Bello, D Hodson, L Gabriel, S Tielemans, E AF Brouwer, Derk Berges, Markus Virji, Mohammed Abbas Fransman, Wouter Bello, Dhimiter Hodson, Laura Gabriel, Stefan Tielemans, Erik TI Harmonization of Measurement Strategies for Exposure to Manufactured Nano-Objects; Report of a Workshop SO ANNALS OF OCCUPATIONAL HYGIENE LA English DT Editorial Material DE core information; database; exposure; harmonization; nanoparticles; strategy ID ENGINEERED NANOMATERIALS; NANOSCALE PARTICLES; STATISTICAL-MODEL; AGREEMENT AB The present paper summarizes the outcome of the discussions at the First International Scientific Workshop on Harmonization of Strategies to Measure and Analyze Exposure to (Manufactured) Nano-objects in Workplace Air that was organized and hosted by the Netherlands Organization for Applied Scientific Research (TNO) and the Institute for Occupational Safety and Health of the German Social Accident Insurance (IFA) (Zeist, The Netherlands, December 2010). It reflects the discussions by 25 international participants in the area of occupational (nano) exposure assessment from Europe, USA, Japan, and Korea on nano-specific issues related to the three identified topics: (i) measurement strategies; (ii) analyzing, evaluating, and reporting of exposure data; and (iii) core information for (exposure) data storage. Preliminary recommendations were achieved with respect to (i) a multimetric approach to exposure assessment, a minimal set of data to be collected, and basic data analysis and reporting as well as (ii) a minimum set of contextual information to be collected and reported. Other issues that have been identified and are of great interest include (i) the need for guidance on statistical approaches to analyze time-series data and on electron microscopy analysis and its reporting and (ii) the need for and possible structure of a (joint) database to store and merge data. To make progress in the process of harmonization, it was concluded that achieving agreement among researchers on the preliminary recommendations of the workshop is urgent. C1 [Brouwer, Derk; Fransman, Wouter; Tielemans, Erik] TNO, Netherlands Org Appl Sci Res, Res Grp Qual & Safety, NL-3700 AJ Zeist, Netherlands. [Berges, Markus; Gabriel, Stefan] DGUV IFA, German Social Accid Insurance Inst Occupat Safety, D-53754 St Augustin, Germany. [Virji, Mohammed Abbas] NIOSH, Ctr Dis Control, Morgantown, WV 26505 USA. [Bello, Dhimiter] Univ Massachusetts, Lowell, MA 01854 USA. [Hodson, Laura] NIOSH, Ctr Dis Control, Cincinnati, OH 45226 USA. RP Brouwer, D (reprint author), TNO, Netherlands Org Appl Sci Res, Res Grp Qual & Safety, POB 360, NL-3700 AJ Zeist, Netherlands. EM dick.brouwer@tno.nl RI Brouwer, Derk/A-1594-2016; Hodson, Laura/F-4585-2011 NR 30 TC 47 Z9 47 U1 0 U2 13 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0003-4878 J9 ANN OCCUP HYG JI Ann. Occup. Hyg. PD JAN PY 2012 VL 56 IS 1 BP 1 EP 9 DI 10.1093/annhyg/mer099 PG 9 WC Public, Environmental & Occupational Health; Toxicology SC Public, Environmental & Occupational Health; Toxicology GA 879RN UT WOS:000299349800001 PM 22156566 ER PT J AU Roberge, RJ Kim, JH Coca, A AF Roberge, Raymond J. Kim, Jung-Hyun Coca, Aitor TI Protective Facemask Impact on Human Thermoregulation: An Overview SO ANNALS OF OCCUPATIONAL HYGIENE LA English DT Review DE comfort; core temperature; PFMs; thermoregulation; tolerance ID HEALTH-CARE WORKERS; FILTERING FACEPIECE RESPIRATORS; HEAT-LOSS; SURGICAL MASK; PHYSIOLOGICAL IMPACT; CORE TEMPERATURE; SKIN TEMPERATURE; RANDOMIZED-TRIAL; N95 RESPIRATOR; HAND HYGIENE AB The use of protective facemasks (PFMs) negatively impacts respiratory and dermal mechanisms of human thermoregulation through impairment of convection, evaporation, and radiation processes. The relatively minor reported increases in core temperature directly attributable to the wearing of PFMs suggest that associated perceptions of increased body temperature may have a significant psychological component or that regional or global brain temperature changes are involved. Modifications in PFM structure, components, and materials might allow for improved heat dissipation and enhanced compliance with use. C1 [Roberge, Raymond J.; Kim, Jung-Hyun; Coca, Aitor] NIOSH, Natl Personal Protect Technol Lab, Ctr Dis Control & Prevent, Washington, DC USA. RP Roberge, RJ (reprint author), NIOSH, Natl Personal Protect Technol Lab, Ctr Dis Control & Prevent, Washington, DC USA. EM dtn0@cdc.gov FU National Personal Protective Technology Laboratory FX National Personal Protective Technology Laboratory internal operating funds. NR 84 TC 13 Z9 13 U1 1 U2 5 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0003-4878 J9 ANN OCCUP HYG JI Ann. Occup. Hyg. PD JAN PY 2012 VL 56 IS 1 BP 102 EP 112 DI 10.1093/annhyg/mer069 PG 11 WC Public, Environmental & Occupational Health; Toxicology SC Public, Environmental & Occupational Health; Toxicology GA 879RN UT WOS:000299349800012 PM 21917820 ER PT J AU Anderka, M Mitchell, AA Louik, C Werler, MM Hernandez-Diaz, S Rasmussen, SA AF Anderka, Marlene Mitchell, Allen A. Louik, Carol Werler, Martha M. Hernandez-Diaz, Sonia Rasmussen, Sonja A. CA Natl Birth Defects Prevention TI Medications used to treat nausea and vomiting of pregnancy and the risk of selected birth defects SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Article DE hypospadias; medications; National Birth Defects Prevention Study; nausea and vomiting of pregnancy; neural tube defects; orofacial clefts ID PROTON-PUMP INHIBITORS; MAJOR MALFORMATIONS; 1ST TRIMESTER; SAFETY; OMEPRAZOLE; METAANALYSIS; PREVENTION; EXPOSURE; DRUGS; CORTICOSTEROIDS AB BACKGROUND Nausea and vomiting of pregnancy (NVP) occurs in up to 80% of pregnant women, but its association with birth outcomes is not clear. Several medications are used for the treatment of NVP; however, data are limited on their possible associations with birth defects. METHODS Using data from the National Birth Defects Prevention Study (NBDPS)a multi-site, population-based, case-control studywe examined whether NVP or its treatment was associated with the most common noncardiac defects in the NBDPS (nonsyndromic cleft lip with or without cleft palate [CL/P], cleft palate alone [CP], neural tube defects, and hypospadias) compared with randomly selected nonmalformed live births. RESULTS Among the 4524 cases and 5859 controls included in this study, 67.1% reported first-trimester NVP, and 15.4% of them reported using at least one agent for NVP. Nausea and vomiting of pregnancy was not associated with CP or neural tube defects, but modest risk reductions were observed for CL/P (adjusted odds ratio [aOR] = 0.87; 95% confidence interval [CI], 0.770.98) and hypospadias (aOR = 0.84; 95% CI, 0.720.98). Regarding treatments for NVP in the first trimester, the following adjusted associations were observed with an increased risk: proton pump inhibitors and hypospadias (aOR = 4.36; 95% CI, 1.2115.81), steroids and hypospadias (aOR = 2.87; 95% CI, 1.037.97), and ondansetron and CP (aOR = 2.37; 95% CI, 1.184.76), whereas antacids were associated with a reduced risk for CL/P (aOR = 0.58; 95% CI, 0.380.89). CONCLUSIONS NVP was not observed to be associated with an increased risk of birth defects; however, possible risks related to three treatments (i.e., proton pump inhibitors, steroids and ondansetron), which could be chance findings, warrant further investigation. Birth Defects Research (Part A) 2012. (C) 2011 Wiley Periodicals, Inc. C1 [Anderka, Marlene] Massachusetts Dept Publ Hlth, Ctr Birth Defects Res & Prevent, Boston, MA 02108 USA. [Mitchell, Allen A.; Louik, Carol; Werler, Martha M.; Hernandez-Diaz, Sonia] Boston Univ, Slone Epidemiol Ctr, Boston, MA 02215 USA. [Hernandez-Diaz, Sonia] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. [Rasmussen, Sonja A.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. RP Anderka, M (reprint author), Massachusetts Dept Publ Hlth, Ctr Birth Defects Res & Prevent, 250 Washington St,5th floor, Boston, MA 02108 USA. EM marlene.anderka@state.ma.us OI Louik, Carol/0000-0001-5429-5084; Mitchell, Allen/0000-0003-0950-6799; Werler, Martha/0000-0003-3392-6814 FU Centers for Disease Control and Prevention [U50/CCU 113247]; MCHB, HHS [1 R03 MC 00004]; Eunice Kennedy Shriver National Institute of Child Health and Human Development [RO1 HD 046595] FX This study was supported by a grant from the Centers for Disease Control and Prevention (U50/CCU 113247), by a New Investigator in MCH Research Dissertation Award from MCHB, HHS (1 R03 MC 00004); and by a grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (RO1 HD 046595). NR 36 TC 55 Z9 55 U1 0 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD JAN PY 2012 VL 94 IS 1 BP 22 EP 30 DI 10.1002/bdra.22865 PG 9 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA 874JE UT WOS:000298951600004 PM 22102545 ER PT J AU Pavkov, ME Knowler, WC Lemley, KV Mason, CC Myers, BD Nelson, RG AF Pavkov, Meda E. Knowler, William C. Lemley, Kevin V. Mason, Clinton C. Myers, Bryan D. Nelson, Robert G. TI Early Renal Function Decline in Type 2 Diabetes SO CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Article ID GLOMERULAR-FILTRATION-RATE; SERUM CYSTATIN-C; KIDNEY-FUNCTION; PIMA-INDIANS; MICROALBUMINURIA; PROGRESSION; GFR; INDIVIDUALS; NEPHROPATHY; CREATININE AB Background and objectives Early decline in GFR may reflect progressive kidney disease in type 1 diabetes, but its predictive value in type 2 diabetes is uncertain. Design, setting, participants, & measurements In this longitudinal study, GFR was measured serially over approximately 4.0 years in 195 Pima Indians with type 2 diabetes. Renal function decline (RFD) was defined during this initial period by an average GFR loss >= 3.3%/yr, as defined previously in type 1 diabetes. Subsequently, participants were followed for up to 17.8 years to ESRD onset, death, or December 31, 2010, whichever came first. Results RFD prevalence during the initial period was 32% in 68 participants with normal baseline albuminuria (albumin/creatinine ratio [ACR] <30 mg/g), 42% in 88 with microalbuminuria (ACR 30 to <300 mg/g), and 74% in 39 with macroalbuminuria (ACR >= 300 mg/g; P<0.001). The cumulative incidence of ESRD 10 years after the initial period was 41% in those with RFD and 15% in those without (P<0.001); 41 of the 49 ESRD cases (83.7%) occurred in participants who had or developed macroalbuminuria during the initial period. When adjusted for age, sex, diabetes duration, and hemoglobin A1c, the ESRD hazard rate was 4.78 times (95% confidence interval, 2.39-9.58) as high in those with RFD as in those without; further adjustment for albuminuria attenuated this association (hazard ratio, 1.79; 95% confidence interval, 0.82-3.91). Conclusions In type 2 diabetes, loss of GFR often occurs before the onset of macroalbuminuria, but a decline predictive of ESRD is strongly dependent on progression to macroalbuminuria. Clin J Am Soc Nephrol 7: 78-84, 2012. doi: 10.2215/CJN.07610711 C1 [Pavkov, Meda E.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Knowler, William C.; Mason, Clinton C.; Nelson, Robert G.] NIDDK, NIH, Phoenix, AZ USA. [Lemley, Kevin V.] Univ So Calif, Keck Sch Med, Childrens Hosp Los Angeles, Dept Pediat, Los Angeles, CA 90033 USA. [Myers, Bryan D.] Stanford Univ, Sch Med, Div Nephrol, Stanford, CA 94305 USA. RP Pavkov, ME (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy NE,MS-K10, Atlanta, GA 30341 USA. EM mpavkov@cdc.gov RI Nelson, Robert/B-1470-2012 FU National Institute of Diabetes and Digestive and Kidney Diseases FX This research was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases. NR 23 TC 27 Z9 29 U1 0 U2 2 PU AMER SOC NEPHROLOGY PI WASHINGTON PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA SN 1555-9041 J9 CLIN J AM SOC NEPHRO JI Clin. J. Am. Soc. Nephrol. PD JAN PY 2012 VL 7 IS 1 BP 78 EP 84 DI 10.2215/CJN.07610711 PG 7 WC Urology & Nephrology SC Urology & Nephrology GA 877RD UT WOS:000299198700014 PM 22076874 ER PT J AU Morassutti, AL Levert, K Pinto, PM da Silva, AJ Wilkins, P Graeff-Teixeira, C AF Morassutti, Alessandra L. Levert, Keith Pinto, Paulo M. da Silva, Alexandre J. Wilkins, Patricia Graeff-Teixeira, Carlos TI Characterization of Angiostrongylus cantonensis excretory-secretory proteins as potential diagnostic targets SO EXPERIMENTAL PARASITOLOGY LA English DT Article DE Angiostrongylus cantonensis; Angiostrongylus costaricensis; ES antigens; Eosinophilic meningoencephalitis; Heterologous antigens ID LINKED-IMMUNOSORBENT-ASSAY; ABDOMINAL ANGIOSTRONGYLIASIS; 1ST REPORT; ANTIGEN; CLONING; BRAZIL; HEAT-SHOCK-PROTEIN-70; METASTRONGYLIDAE; RESPONSES; NEMATODA AB Angiostrongyliasis results from infections with intra-arterial nematodes that accidentally infect humans. Specifically, infections with Angiostrongylus cantonensis cause eosinophilic meningitis and Angiostrongylus costaricensis infections result in eosinophilic enteritis. Immunological tests are the primary means of diagnosing infections with either pathogen since these parasites are usually not recoverable in fecal or cerebrospinal fluid. However, well-defined, purified antigens are not currently available in sufficient quantities from either pathogen for use in routine immunodiagnostic assays. Since A. costaricensis and A. cantonensis share common antigens, sera from infected persons will recognize antigens from either species. In addition to their potential use in angiostrongyliasis diagnosis, characterization of these proteins that establish the host-parasite interphase would improve our understanding of the biology of these parasites. The main objective of the present work was to characterize A. cantonensis excretory-secretory (ES) products by analyzing ES preparations by two-dimensional gel electrophoresis coupled with immunoblotting using pools of positive sera (PS) and sera from healthy individuals (SC). Protein spots recognized by PS were excised and analyzed by electrospray ionization (ESI) mass spectrometry. MASCOT analysis of mass spectrometry data identified 17 proteins: aldolase; CBR-PYP-1 protein; beta-amylase; heat shock protein 70; proteosome subunit beta type-1; actin A3; peroxiredoxin; serine carboxypeptidase; protein disulfide isomerase 1; fructose-bisphosphate aldolase 2; aspartyl protease inhibitor; lectin-5; hypothetical protein F01F1.12; cathepsin B-like cysteine proteinase 1; hemoglobinase-type cysteine proteinase; putative ferritin protein 2; and a hypothetical protein. Molecular cloning of these respective targets will next be carried out to develop a panel of Angiostrongylus antigens that can be used for diagnostic purposes and to further study host-Angiostrongylus interactions. (C) 2011 Elsevier Inc. All rights reserved. C1 [Morassutti, Alessandra L.; Graeff-Teixeira, Carlos] Pontificia Univ Rio Grande Sul PUCRS, Fac Biociencias, Lab Biol Parasitaria, BR-90690900 Porto Alegre, RS, Brazil. [Morassutti, Alessandra L.; Graeff-Teixeira, Carlos] Pontificia Univ Rio Grande Sul PUCRS, Inst Pesquisas Biomed, Lab Parasitol Mol, BR-90690900 Porto Alegre, RS, Brazil. [Levert, Keith] Georgia State Univ, Dept Biol, Atlanta, GA 30302 USA. [Pinto, Paulo M.] Univ Fed Pampa, BR-97300000 Sao Gabriel, RS, Brazil. [Levert, Keith; da Silva, Alexandre J.; Wilkins, Patricia] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Morassutti, AL (reprint author), Pontificia Univ Catolica Rio Grande do Sul, Inst Pesquisas Biomed, Ave Ipiranga 6690,2 Andar,Sala 20, BR-90690900 Porto Alegre, RS, Brazil. EM almorassutti@gmail.com RI Graeff-Teixeira, Carlos/A-5820-2012; Pinto, Paulo/K-6921-2014; Morassutti, Alessandra/E-1046-2015 OI Graeff-Teixeira, Carlos/0000-0003-2725-0061; Pinto, Paulo/0000-0002-8513-0335; Morassutti, Alessandra/0000-0002-8142-1055 FU CNPq; CAPES; FAPERGS; Conselho Nacional de Pesquisa e Desenvolvimento Tecnologico do Brazil [300456/2007-7, 477260/2007-1] FX Financial support was provided by CNPq, CAPES, and FAPERGS. C. Graeff-Teixeira is a recipient of a CNPq PQ 1D fellowship and of Grants 300456/2007-7 and 477260/2007-1 (Conselho Nacional de Pesquisa e Desenvolvimento Tecnologico do Brazil). NR 33 TC 14 Z9 15 U1 1 U2 13 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0014-4894 J9 EXP PARASITOL JI Exp. Parasitol. PD JAN PY 2012 VL 130 IS 1 BP 26 EP 31 DI 10.1016/j.exppara.2011.10.003 PG 6 WC Parasitology SC Parasitology GA 877NN UT WOS:000299189300005 PM 22019415 ER PT J AU Bellcross, CA Bedrosian, SR Daniels, E Duquette, D Hampel, H Jasperson, K Joseph, DA Kaye, C Lubin, I Meyer, LJ Reyes, M Scheuner, MT Schully, SD Senter, L Stewart, SL St Pierre, J Westman, J Wise, P Yang, VW Khoury, MJ AF Bellcross, Cecelia A. Bedrosian, Sara R. Daniels, Elvan Duquette, Debra Hampel, Heather Jasperson, Kory Joseph, Djenaba A. Kaye, Celia Lubin, Ira Meyer, Laurence J. Reyes, Michele Scheuner, Maren T. Schully, Sheri D. Senter, Leigha Stewart, Sherri L. St Pierre, Jeanette Westman, Judith Wise, Paul Yang, Vincent W. Khoury, Muin J. TI Implementing screening for Lynch syndrome among patients with newly diagnosed colorectal cancer: summary of a public health/clinical collaborative meeting SO GENETICS IN MEDICINE LA English DT Article DE colorectal cancer; genetic screening; genetic testing; HNPCC; Lynch syndrome ID CUMULATIVE LIFETIME INCIDENCE; GENETIC TESTING STRATEGIES; MISMATCH REPAIR PROTEINS; EGAPP WORKING GROUP; MICROSATELLITE INSTABILITY; ENDOMETRIAL CANCER; REDUCING MORBIDITY; MUTATION CARRIERS; PROVEN MUTATIONS; MLH1 PROMOTER AB Lynch syndrome is the most common cause of inherited colorectal cancer, accounting for approximately 3% of all colorectal cancer cases in the United States. In 2009, an evidence-based review process conducted by the independent Evaluation of Genomic Applications in Practice and Prevention Working Group resulted in a recommendation to offer genetic testing for Lynch syndrome to all individuals with newly diagnosed colorectal cancer, with the intent of reducing morbidity and mortality in family members. To explore issues surrounding implementation of this recommendation, the Centers for Disease Control and Prevention convened a multidisciplinary working group meeting in September 2010. This article reviews background information regarding screening for Lynch syndrome and summarizes existing clinical paradigms, potential implementation strategies, and conclusions which emerged from the meeting. It was recognized that widespread implementation will present substantial challenges, and additional data from pilot studies will be needed. However, evidence of feasibility and population health benefits and the advantages of considering a public health approach were acknowledged. Lynch syndrome can potentially serve as a model to facilitate the development and implementation of population-level programs for evidence-based genomic medicine applications involving follow-up testing of at-risk relatives. Such endeavors will require multilevel and multidisciplinary approaches building on collaborative public health and clinical partnerships. C1 [Bellcross, Cecelia A.; Bedrosian, Sara R.; Reyes, Michele; St Pierre, Jeanette; Khoury, Muin J.] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA 30333 USA. [Bellcross, Cecelia A.] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA USA. [Daniels, Elvan] Morehouse Sch Med, Natl Ctr Primary Care, Atlanta, GA 30310 USA. [Duquette, Debra] Michigan Dept Community Hlth, Lansing, MI USA. [Hampel, Heather; Senter, Leigha; Westman, Judith] Ohio State Univ, Dept Internal Med, Div Human Genet, Ctr Comprehens Canc, Columbus, OH 43210 USA. [Jasperson, Kory] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA. [Joseph, Djenaba A.; Stewart, Sherri L.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA USA. [Kaye, Celia] Univ Colorado, Off Educ Dev & Res, Sch Med, Aurora, CO USA. [Lubin, Ira] Ctr Dis Control & Prevent, Lab Res & Evaluat Branch, Atlanta, GA USA. [Meyer, Laurence J.] Salt Lake City Hlth Care Syst, Dept Vet Affairs, Salt Lake City, UT USA. [Scheuner, Maren T.] Greater Los Angeles Healthcare Syst, Dept Vet Affairs, Los Angeles, CA USA. [Scheuner, Maren T.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA. [Schully, Sheri D.] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. [Wise, Paul] Vanderbilt Univ, Dept Surg, Med Ctr, Nashville, TN 37240 USA. [Yang, Vincent W.] Emory Univ, Sch Med, Div Digest Dis, Atlanta, GA USA. RP Bellcross, CA (reprint author), Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA 30333 USA. EM cbellcr@emory.edu OI Wise, Paul/0000-0003-3798-7913 FU NCI NIH HHS [R01 CA084197]; NIDDK NIH HHS [R01 DK052230] NR 62 TC 32 Z9 33 U1 0 U2 4 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1098-3600 J9 GENET MED JI Genet. Med. PD JAN PY 2012 VL 14 IS 1 BP 152 EP 162 DI 10.1038/gim.0b013e31823375ea PG 11 WC Genetics & Heredity SC Genetics & Heredity GA 873NI UT WOS:000298889600019 PM 22237445 ER PT J AU Schully, SD Benedicto, CB Khoury, MJ AF Schully, Sheri D. Benedicto, Camilla B. Khoury, Muin J. TI How can we stimulate translational research in cancer genomics beyond bench to bedside? SO GENETICS IN MEDICINE LA English DT Letter C1 [Schully, Sheri D.; Benedicto, Camilla B.; Khoury, Muin J.] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. [Khoury, Muin J.] CDC, Off Publ Hlth Genom, Atlanta, GA 30333 USA. RP Schully, SD (reprint author), NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. EM schullys@mail.nih.gov NR 6 TC 12 Z9 12 U1 0 U2 2 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1098-3600 J9 GENET MED JI Genet. Med. PD JAN PY 2012 VL 14 IS 1 BP 169 EP 170 DI 10.1038/gim.2011.12 PG 2 WC Genetics & Heredity SC Genetics & Heredity GA 873NI UT WOS:000298889600022 PM 22237448 ER PT J AU Zhuo, XH Zhang, P Gregg, EW Barker, L Hoerger, TJ Pearson-Clarke, T Albright, A AF Zhuo, Xiaohui Zhang, Ping Gregg, Edward W. Barker, Lawrence Hoerger, Thomas J. Pearson-Clarke, Tony Albright, Ann TI A Nationwide Community-Based Lifestyle Program Could Delay Or Prevent Type 2 Diabetes Cases And Save $5.7 Billion In 25 Years SO HEALTH AFFAIRS LA English DT Article ID WEIGHT-LOSS; COST-EFFECTIVENESS; FINANCIAL IMPACT; RISK; INTERVENTION; HYPERTENSION; REDUCTION; METFORMIN; PROJECT; PEOPLE AB The increasing health and economic burden of diabetes has made preventing the disease a public health priority. But investing in such chronic disease prevention programs requires a long-term horizon because many years may be required for the downstream savings to fully offset the up-front intervention cost. Using a simulation model, we projected the costs and benefits of a nationwide community-based lifestyle intervention program for preventing type 2 diabetes. Accounting for all costs to the US health care system, our results indicate that the program would break even in fourteen years. Within twenty-five years, the program would prevent or delay about 885,000 cases of type 2 diabetes in the United States and produce savings of $5.7 billion nationwide. If restricted to people ages 65-84, the program would save $2.4 billion. Thus, implementing such a program nationwide would be an efficient use of health care resources, although it might be necessary for all health insurers to participate to share prevention costs. Our results also indicate that although a prevention program would lead to cost savings in both younger and older people, it would achieve greater health and economic gains if it were directed at people under age sixty-five. C1 [Zhuo, Xiaohui] Ctr Dis Control & Prevent CDC, Atlanta, GA USA. [Gregg, Edward W.] CDC, Div Heart Dis & Stroke Prevent, Atlanta, GA 30333 USA. [Hoerger, Thomas J.] RTI UNC Ctr Excellence Hlth Promot Econ, Res Triangle Pk, NC USA. [Albright, Ann] CDC, Div Diabet Translat, Atlanta, GA 30333 USA. RP Zhuo, XH (reprint author), Ctr Dis Control & Prevent CDC, Atlanta, GA USA. EM iip6@cdc.gov NR 42 TC 16 Z9 16 U1 0 U2 10 PU PROJECT HOPE PI BETHESDA PA 7500 OLD GEORGETOWN RD, STE 600, BETHESDA, MD 20814-6133 USA SN 0278-2715 J9 HEALTH AFFAIR JI Health Aff. PD JAN PY 2012 VL 31 IS 1 BP 50 EP 60 DI 10.1377/hlthaff.2011.1115 PG 11 WC Health Care Sciences & Services; Health Policy & Services SC Health Care Sciences & Services GA 879DD UT WOS:000299309000008 PM 22232094 ER PT J AU Uhrig, JD Davis, KC Rupert, D Fraze, J AF Uhrig, Jennifer D. Davis, Kevin C. Rupert, Doug Fraze, Jami TI Behavioural precursors and HIV testing behaviour among African American women SO HEALTH EDUCATION JOURNAL LA English DT Article DE African American women; behaviour change; HIV; intentions; theory ID RANDOMIZED CONTROLLED-TRIAL; REASONED ACTION; PLANNED BEHAVIOR; SELF-EXAMINATION; CONDOM USE; RISK; PREVENTION; CAMPAIGNS; EFFICACY; PROGRAM AB Objective: To examine whether there is an association between knowledge, attitudes and beliefs, reported intentions to get an HIV test, and reported HIV testing behaviour at a later date among a sample of African American women. Design: Secondary analysis of data collected from October 2007 through March 2008 for a randomized controlled experiment that was one part of a comprehensive evaluation of the 'Take Charge. Take the Test' HIV social marketing campaign. Method: A series of logistic regression models were estimated to assess the effects of baseline knowledge and attitudes and beliefs on intention at two and six weeks post-baseline. Logistic regression models were also estimated to assess the effects of intention on HIV testing at both follow-ups. Results: A statistically-significant association between baseline attitudes and beliefs and subsequent HIV testing intentions was found. Knowing where to get a free HIV test at baseline was also significantly associated with reported intentions at follow-up. Reported intentions were significantly associated with reported HIV testing at follow-up. Conclusion: The study's findings reiterate the importance of applying behaviour change theories and measuring behavioural precursors in the design and evaluation of HIV testing campaigns. C1 [Uhrig, Jennifer D.; Davis, Kevin C.; Rupert, Doug] RTI Int, Res Triangle Pk, NC 27709 USA. [Fraze, Jami] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Uhrig, JD (reprint author), RTI Int, 3040 Cornwallis Rd,POB 12194, Res Triangle Pk, NC 27709 USA. EM uhrig@rti.org NR 35 TC 2 Z9 2 U1 4 U2 6 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0017-8969 J9 HEALTH EDUC J JI Health Educ. J. PD JAN PY 2012 VL 71 IS 1 BP 102 EP 114 DI 10.1177/0017896910386528 PG 13 WC Education & Educational Research; Public, Environmental & Occupational Health SC Education & Educational Research; Public, Environmental & Occupational Health GA 880CP UT WOS:000299382500011 ER PT J AU Swahn, MH Ali, B Bossarte, RM Van Dulmen, M Crosby, A Jones, AC Schinka, KC AF Swahn, Monica H. Ali, Bina Bossarte, Robert M. Van Dulmen, Manfred Crosby, Alex Jones, Angela C. Schinka, Katherine C. TI Self-Harm and Suicide Attempts among High-Risk, Urban Youth in the U.S.: Shared and Unique Risk and Protective Factors SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH LA English DT Article DE self-harm; suicide attempt; youth; adolescents; US; high-risk; school; cross-sectional ID COMMUNITY SAMPLE; ADOLESCENTS; INJURY; PREDICTORS; BEHAVIORS; ALCOHOL; PREVALENCE; SYMPTOMS; GENDER; AGE AB The extent to which self-harm and suicidal behavior overlap in community samples of vulnerable youth is not well known. Secondary analyses were conducted of the "linkages study" (N = 4,131), a cross-sectional survey of students enrolled in grades 7, 9, 11/12 in a high-risk community in the U.S. in 2004. Analyses were conducted to determine the risk and protective factors (i.e., academic grades, binge drinking, illicit drug use, weapon carrying, child maltreatment, social support, depression, impulsivity, self-efficacy, parental support, and parental monitoring) associated with both self-harm and suicide attempt. Findings show that 7.5% of participants reported both self-harm and suicide attempt, 2.2% of participants reported suicide attempt only, and 12.4% of participants reported self-harm only. Shared risk factors for co-occurring self-harm and suicide attempt include depression, binge drinking, weapon carrying, child maltreatment, and impulsivity. There were also important differences by sex, grade level, and race/ethnicity that should be considered for future research. The findings show that there is significant overlap in the modifiable risk factors associated with self-harm and suicide attempt that can be targeted for future research and prevention strategies. C1 [Swahn, Monica H.; Ali, Bina] Georgia State Univ, Inst Publ Hlth, Atlanta, GA 30303 USA. [Bossarte, Robert M.] Univ Rochester, Dept Psychiat, Rochester, NY 14424 USA. [Van Dulmen, Manfred; Schinka, Katherine C.] Kent State Univ, Dept Psychol, Kent, OH 44242 USA. [Crosby, Alex] Ctr Dis Control & Prevent, Div Violence Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30329 USA. [Jones, Angela C.] John Carroll Univ, Dept Psychol, University Height, OH 44118 USA. RP Swahn, MH (reprint author), Georgia State Univ, Inst Publ Hlth, 50 Decatur St SE, Atlanta, GA 30303 USA. EM mswahn@gsu.edu; bina226@gmail.com; robert_bossarte@urmc.rochester.edu; manfredathome@gmail.com; aec1@cdc.gov; acjones@jcu.edu; kschinka@gmail.com RI van Dulmen, Manfred/F-5916-2010 OI van Dulmen, Manfred/0000-0002-0018-4562 FU Centers for Disease Control and Prevention [R01 CE001395]; Bossarte; Swahn FX We thank the entire Linkages Study team from ORC Macro, CDC and Battelle who contributed to the planning and implementation of the study. We also thank the school district for their enthusiasm and logistical support of this project. Finally, we thank the students for their time and willingness to participate in this study. We also note that the preparation of this manuscript was partially supported by funding from the Centers for Disease Control and Prevention R01 CE001395 to Van Dulmen, Bossarte and Swahn. NR 55 TC 22 Z9 24 U1 2 U2 18 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1660-4601 J9 INT J ENV RES PUB HE JI Int. J. Environ. Res. Public Health PD JAN PY 2012 VL 9 IS 1 BP 178 EP 191 DI 10.3390/ijerph9010178 PG 14 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 881ZX UT WOS:000299532000013 PM 22470286 ER PT J AU Barbouni, A Hadjichristodoulou, C Merakou, K Antoniadou, E Kourea, K Miloni, E Warren, CW Rahiotis, G Kremastinou, J AF Barbouni, Anastasia Hadjichristodoulou, Christos Merakou, Kyriakoula Antoniadou, Eleni Kourea, Kallirrhoe Miloni, Evangelia Warren, Charles W. Rahiotis, George Kremastinou, Jenny TI Tobacco Use, Exposure to Secondhand Smoke, and Cessation Counseling Among Health Professions Students: Greek Data from the Global Health Professions Student Survey (GHPSS) SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH LA English DT Article DE tobacco; smoking; prevalence; students; secondhand smoke; health profession; cessation; survey AB We conducted the GHPSS (Global Health Professions Student Survey) to obtain information regarding health profession students' smoking habits and perceptions, exposure to secondhand smoke (SHS) as well as level of knowledge and training on tobacco use and smoking cessation counseling. GHPSS is a survey for third-year students in the following fields: health visitors, dentistry, medicine, nursing and/or pharmacy. The highest tobacco use prevalence rate and exposure to SHS were recorded among health visitor students with 46.4% and 33.3% respectively. The majority of the respondents believed that their profession serves as a role model for their patients. Formal training on cessation counseling ranged between 10.7% for health visitor students to 22.4% for nursing students. The relatively high percentage of health profession students who currently smoke and the alarmingly high percentage of those exposed to SHS indicate lack of concerted efforts for implementation and effective enforcement of the anti-tobacco policy measures. Despite its significance, formal training on cessation counseling for students is strikingly low. These results indicate the urgent need to train health professional students on tobacco cessation counseling and educate them on the dangers of tobacco use, SHS and the positively influential role they can play to affect their patients' smoking habits. C1 [Barbouni, Anastasia; Merakou, Kyriakoula; Antoniadou, Eleni; Kourea, Kallirrhoe; Miloni, Evangelia; Kremastinou, Jenny] Natl Sch Publ Hlth, Dept Publ Hlth, Athens 11521, Greece. [Hadjichristodoulou, Christos; Rahiotis, George] Univ Thessaly, Dept Hyg & Epidemiol, Fac Med, Larisa 41222, Greece. [Warren, Charles W.] Ctr Dis Control & Prevent, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. RP Barbouni, A (reprint author), Natl Sch Publ Hlth, Dept Publ Hlth, Alexandras Av 196, Athens 11521, Greece. EM abarbouni@esdy.edu.gr; xhatzi@med.uth.gr; kmerakou@esdy.edu.gr; eantoniadou@gmail.com; publichealth@esdy.edu.gr; m-kelly@live.com; wcw1@cdc.gov; grach@med.uth.gr; jkremastinou@esdy.edu.gr NR 18 TC 6 Z9 6 U1 3 U2 12 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1660-4601 J9 INT J ENV RES PUB HE JI Int. J. Environ. Res. Public Health PD JAN PY 2012 VL 9 IS 1 BP 331 EP 342 PG 12 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 881ZX UT WOS:000299532000022 PM 22470295 ER PT J AU Hallman, DM Friedel, VC Eissa, MAH Boerwinkle, E Huber, JC Harrist, RB Srinivasan, SR Chen, W Dai, S Labarthe, DR Berenson, GS AF Hallman, D. M. Friedel, V. C. Eissa, M. A. H. Boerwinkle, E. Huber, J. C., Jr. Harrist, R. B. Srinivasan, S. R. Chen, W. Dai, S. Labarthe, D. R. Berenson, G. S. TI The association of variants in the FTO gene with longitudinal body mass index profiles in non-Hispanic white children and adolescents SO INTERNATIONAL JOURNAL OF OBESITY LA English DT Article DE FTO; body mass index; children; adolescents; longitudinal study ID GENOME-WIDE ASSOCIATION; OBESITY-RELATED TRAITS; FAT MASS; ADULT OBESITY; ENERGY-INTAKE; POPULATION; CHILDHOOD; BMI; POLYMORPHISMS; CHINESE AB Objective: To investigate possible age-related changes in associations between polymorphisms in the fat mass and obesity-associated (FTO) gene and higher body mass index (BMI). Design and subjects: Multilevel mixed regression models were used to examine associations between four FTO variants and longitudinal BMI profiles in non-Hispanic white and African American children and adolescents 8-17 years of age from two different longitudinal cohort studies, the Bogalusa Heart Study (BHS) and Project HeartBeat! (PHB). In the BHS, there were 1551 examinations of 478 African Americans and 3210 examinations of 1081 non-Hispanic whites; in PHB, there were 971 examinations of 131 African Americans and 4458 examinations of 505 non-Hispanic whites. Results: In African Americans, no significant FTO associations with BMI were found. In non-Hispanic whites, linkage disequilibrium among all four variants made haplotype analysis superfluous, so we focused on the single-nucleotide polymorphism, rs9939609. In longitudinal multilevel models, the A/A genotype of rs9939609 was associated with higher BMI in non-Hispanic whites in both cohorts at all ages. A significant age-by-genotype interaction found only in the BHS cohort predicted that in those with the A/A genotype, BMI would be similar to 0.7 kgm(-2) higher at age 8 and similar to 1.6 kgm(-2) higher at age 17 than in those with A/T or T/T genotypes. The design of PHB limited follow-up of any single individual to 4 years, and may have reduced the ability to detect any age-by-genotype interaction in this cohort. Conclusions: The A/A genotype of rs9939609 in the FTO gene is associated with higher longitudinal BMI profiles in non-Hispanic whites from two different cohorts. The association may change with age, with the A/A genotype being associated with a larger BMI difference in late adolescence than in childhood, though this was observed only in the BHS cohort and requires verification. International Journal of Obesity (2012) 36, 61-68; doi:10.1038/ijo.2011.190; published online 11 October 2011 C1 [Hallman, D. M.; Friedel, V. C.; Boerwinkle, E.] Univ Texas Houston, Sch Publ Hlth, Ctr Human Genet, Houston, TX 77225 USA. [Eissa, M. A. H.] Univ Texas Houston, Sch Med, Dept Pediat, Houston, TX 77225 USA. [Boerwinkle, E.] Univ Texas Hlth Sci Ctr Houston, Inst Mol Med, Houston, TX USA. [Huber, J. C., Jr.] Texas A&M Univ, Dept Epidemiol & Biostat, Sch Rural Publ Hlth, College Stn, TX USA. [Harrist, R. B.] Univ Texas Austin, Sch Publ Hlth, Div Biostat, Austin, TX 78712 USA. [Srinivasan, S. R.; Chen, W.; Berenson, G. S.] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, Ctr Cardiovasc Hlth, New Orleans, LA USA. [Dai, S.; Labarthe, D. R.] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA USA. RP Hallman, DM (reprint author), Univ Texas Houston, Sch Publ Hlth, Ctr Human Genet, POB 20334, Houston, TX 77225 USA. EM D.Michael.Hallman@uth.tmc.edu FU National Heart, Lung and Blood Institute [HL070568, HL089472]; National Institute of Diabetes and Digestive and Kidney Diseases [DK073618]; National Institute of Child Health and Human Development [HD061437, HD062783]; National Institute on Aging [AG016592]; American Heart Association [0855082E] FX This work was supported by the National Heart, Lung and Blood Institute grants HL070568 and HL089472 and the National Institute of Diabetes and Digestive and Kidney Diseases grant DK073618 (to DMH) and by the National Institute of Child Health and Human Development grants HD061437 and HD062783, the National Institute on Aging grant AG016592, and the American Heart Association grant 0855082E (to GSB). We wish to express our gratitude to the subjects and staff members of the PHB and the BHS. NR 33 TC 16 Z9 17 U1 2 U2 6 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0307-0565 J9 INT J OBESITY JI Int. J. Obes. PD JAN PY 2012 VL 36 IS 1 BP 61 EP 68 DI 10.1038/ijo.2011.190 PG 8 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA 879CG UT WOS:000299306700008 PM 21986706 ER PT J AU Peacock, G Amendah, D Ouyang, LJ Grosse, SD AF Peacock, Georgina Amendah, Djesika Ouyang, Lijing Grosse, Scott D. TI Autism Spectrum Disorders and Health Care Expenditures: The Effects of Co-Occurring Conditions SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS LA English DT Article DE cost; health care use; expenditures; Medicaid; autism spectrum disorder; hyperkinetic syndrome; seizures; ID ID CHILDREN; COSTS AB Objective: Children with autism spectrum disorders (ASDs) often have co-occurring conditions, but little is known on the effect of those conditions on their medical care cost. Medical expenditures attributable to ASDs among Medicaid-enrolled children were calculated, and the effects of 3 commonly co-occurring conditions-intellectual disability (ID), attention deficit/hyperactivity disorder (ADHD), and epilepsy-on those expenditures were analyzed. Methods: Using MarketScan Medicaid Multi-State Databases (2003-2005) and the International Classification of Disease, Ninth Revision, children with ASD were identified. Children without ASD formed the comparison group. The 3 co-occurring conditions were identified among both the ASD and the comparison groups. Annual mean, median, and 95th percentile of total expenditures were calculated for children with ASD and the co-occurring conditions and compared with those of children without ASD. Multivariate analyses established the influence of each of those co-occurring conditions on the average expenditures for children with and without ASD. Results: In 2005, 47% of children with ASD had at least 1 selected co-occurring condition; attention deficit/hyperactivity disorder was the most common, at 30%. The mean medical expenditures for children with ASD were 6 times higher than those of the comparison group. Children with ASD and ID incurred expenditures 2.7 times higher than did children with ASD and no co-occurring condition. Conclusion: Medicaid-enrolled children with ASD incurred higher medical costs than did Medicaid-enrolled children without ASD. Among Medicaid-enrolled children with ASD, cost varied substantially based on the presence of another neurodevelopmental disorder. In particular, children with ID had much higher costs than did other children with ASD. C1 [Peacock, Georgina; Amendah, Djesika; Ouyang, Lijing; Grosse, Scott D.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Amendah, Djesika] African Populat & Hlth Res Ctr, Nairobi, Kenya. RP Peacock, G (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS E-86, Atlanta, GA 30333 USA. EM gpeacock@cdc.gov NR 10 TC 37 Z9 37 U1 1 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0196-206X J9 J DEV BEHAV PEDIATR JI J. Dev. Behav. Pediatr. PD JAN PY 2012 VL 33 IS 1 BP 2 EP 8 DI 10.1097/DBP.0b013e31823969de PG 7 WC Behavioral Sciences; Psychology, Developmental; Pediatrics SC Behavioral Sciences; Psychology; Pediatrics GA 880FY UT WOS:000299391700002 PM 22157409 ER PT J AU Ghandour, RM Kogan, MD Blumberg, SJ Jones, JR Perrin, JM AF Ghandour, Reem M. Kogan, Michael D. Blumberg, Stephen J. Jones, Jessica R. Perrin, James M. TI Mental Health Conditions Among School-Aged Children: Geographic and Sociodemographic Patterns in Prevalence and Treatment SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS LA English DT Article DE mood disorders; conduct disorders; children; treatment; geographic variation ID COMORBIDITY SURVEY REPLICATION; SUPPLEMENT NCS-A; US CHILDREN; PSYCHIATRIC-DISORDERS; LIFETIME PREVALENCE; SERVICE UTILIZATION; CONDUCT PROBLEMS; RISK BEHAVIORS; ADOLESCENTS; STATE AB Objective: To explore geographic differences in diagnosed emotional and behavioral mental health conditions and receipt of treatment. Methods: Data are from the 2007 National Survey of Children's Health, a nationally representative, parent-reported, cross-sectional survey. Pediatric mental health conditions were identified using parents' responses to 3 questions regarding whether a health care provider had ever told them that their child had depression, anxiety problems, or behavioral or conduct problems. Parents also reported on past-year treatment or counseling by a mental health professional. State-level differences in condition prevalence were identified using unadjusted and adjusted prevalence estimates. Multivariate logistic regression assessed the odds of not receiving treatment by state and diagnoses. Results: Nearly 8% of children aged 6 to 17 years have ever been diagnosed with depression or anxiety, and 5.4% have ever been diagnosed with behavioral or conduct problems. State-level estimates of parent-reported depression or anxiety varied from 4.8% in Georgia to 14.4% in Vermont, while prevalence of behavioral problems ranged from 3.2% in California to 9.2% in Louisiana. Nearly 10% of all school-aged children and 53.1% of those ever diagnosed with either condition type received past-year treatment. The odds of receiving past-year parent-reported treatment did not differ by state of residence with the exception of Louisiana and Nevada: children ever diagnosed had approximately 2.5 times the odds of not receiving past-year treatment in these states. Conclusion: The prevalence of parent-reported mental health disorders among children varies by geographic and sociodemographic factors, while receipt of treatment is generally dependent on sociodemographic and health-related factors. C1 [Ghandour, Reem M.] US Hlth Resources & Serv Adm, Off Epidemiol Policy & Evaluat, Maternal & Child Hlth Bur, Rockville, MD 20857 USA. [Blumberg, Stephen J.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Perrin, James M.] Massachusetts Gen Hosp, Ctr Child & Adolescent Hlth Policy, Boston, MA 02114 USA. RP Ghandour, RM (reprint author), US Hlth Resources & Serv Adm, Off Epidemiol Policy & Evaluat, Maternal & Child Hlth Bur, 5600 Fishers Lane,Room 18-41, Rockville, MD 20857 USA. EM rghandour@hrsa.gov NR 48 TC 13 Z9 13 U1 1 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0196-206X J9 J DEV BEHAV PEDIATR JI J. Dev. Behav. Pediatr. PD JAN PY 2012 VL 33 IS 1 BP 42 EP 54 DI 10.1097/DBP.0b013e31823e18fd PG 13 WC Behavioral Sciences; Psychology, Developmental; Pediatrics SC Behavioral Sciences; Psychology; Pediatrics GA 880FY UT WOS:000299391700012 PM 22218014 ER PT J AU Zeng, H Pappas, C Belser, JA Houser, KV Zhong, WM Wadford, DA Stevens, T Balczon, R Katz, JM Tumpey, TM AF Zeng, Hui Pappas, Claudia Belser, Jessica A. Houser, Katherine V. Zhong, Weiming Wadford, Debra A. Stevens, Troy Balczon, Ron Katz, Jacqueline M. Tumpey, Terrence M. TI Human Pulmonary Microvascular Endothelial Cells Support Productive Replication of Highly Pathogenic Avian Influenza Viruses: Possible Involvement in the Pathogenesis of Human H5N1 Virus Infection SO JOURNAL OF VIROLOGY LA English DT Article ID LOWER RESPIRATORY-TRACT; BRONCHIAL EPITHELIAL-CELLS; ACUTE LUNG INJURY; A SUBTYPE H5N1; MYCOBACTERIUM-TUBERCULOSIS; COMPARATIVE PATHOLOGY; RECEPTOR SPECIFICITY; HUMAN AIRWAY; H7 VIRUSES; HEMAGGLUTININ AB Highly pathogenic avian influenza (HPAI) H5N1 viruses continue to cause sporadic human infections with a high fatality rate. Respiratory failure due to acute respiratory distress syndrome (ARDS) is a complication among hospitalized patients. Since progressive pulmonary endothelial damage is the hallmark of ARDS, we investigated host responses following HPAI virus infection of human pulmonary microvascular endothelial cells. Evaluation of these cells for the presence of receptors preferred by influenza virus demonstrated that avian-like (alpha 2-3-linked) receptors were more abundant than human-like (alpha 2-6-linked) receptors. To test the permissiveness of pulmonary endothelial cells to virus infection, we compared the replication of selected seasonal, pandemic (2009 H1N1 and 1918), and potentially pandemic (H5N1) influenza virus strains. We observed that these cells support productive replication only of HPAI H5N1 viruses, which preferentially enter through and are released from the apical surface of polarized human endothelial monolayers. Furthermore, A/Thailand/16/2004 and A/Vietnam/1203/2004 (VN/1203) H5N1 viruses, which exhibit heightened virulence in mammalian models, replicated to higher titers than less virulent H5N1 strains. VN/1203 infection caused a significant decrease in endothelial cell proliferation compared to other subtype viruses. VN/1203 virus was also found to be a potent inducer of cytokines and adhesion molecules known to regulate inflammation during acute lung injury. Deletion of the H5 hemagglutinin (HA) multibasic cleavage site did not affect virus infectivity but resulted in decreased virus replication in endothelial cells. Our results highlight remarkable tropism and infectivity of the H5N1 viruses for human pulmonary endothelial cells, resulting in the potent induction of host inflammatory responses. C1 [Zeng, Hui; Pappas, Claudia; Belser, Jessica A.; Houser, Katherine V.; Zhong, Weiming; Wadford, Debra A.; Katz, Jacqueline M.; Tumpey, Terrence M.] Ctr Dis Control & Prevent, Immunol & Pathogenesis Branch, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Balczon, Ron] Univ S Alabama, Dept Cell Biol & Neurosci, Mobile, AL 36688 USA. [Stevens, Troy] Univ S Alabama, Dept Pharmacol, Mobile, AL 36688 USA. [Stevens, Troy; Balczon, Ron] Univ S Alabama, Ctr Lung Biol, Mobile, AL 36688 USA. RP Tumpey, TM (reprint author), Ctr Dis Control & Prevent, Immunol & Pathogenesis Branch, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM tft9@cdc.gov FU NIH [HL-60024, HL-66299] FX This research was funded in part by NIH grants HL-60024 and HL-66299 to T.S. NR 57 TC 36 Z9 41 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD JAN PY 2012 VL 86 IS 2 BP 667 EP 678 DI 10.1128/JVI.06348-11 PG 12 WC Virology SC Virology GA 870MW UT WOS:000298674600003 PM 22072765 ER PT J AU Dobard, C Sharma, S Martin, A Pau, CP Holder, A Kuklenyik, Z Lipscomb, J Hanson, DL Smith, J Novembre, FJ Garcia-Lerma, JG Heneine, W AF Dobard, Charles Sharma, Sunita Martin, Amy Pau, Chou-Pong Holder, Angela Kuklenyik, Zsuzsanna Lipscomb, Jonathan Hanson, Debra L. Smith, James Novembre, Francis J. Garcia-Lerma, J. Gerardo Heneine, Walid TI Durable Protection from Vaginal Simian-Human Immunodeficiency Virus Infection in Macaques by Tenofovir Gel and Its Relationship to Drug Levels in Tissue SO JOURNAL OF VIROLOGY LA English DT Article ID RHESUS MACAQUES; REVERSE-TRANSCRIPTASE; HIV-INFECTION; GENITAL-TRACT; TRANSMISSION; WOMEN; SUSCEPTIBILITY; PROPHYLAXIS; NUCLEOSIDE; PREVENTION AB A vaginal gel containing 1% tenofovir (TFV) was found to be safe and effective in reducing HIV infection in women when used pericoitally. Because of the long intracellular half-life of TFV and high drug exposure in vaginal tissues, we hypothesized that a vaginal gel containing TFV may provide long-lasting protection. Here, we performed delayed-challenge experiments and showed that vaginal 1% TFV gel protected 4/6 macaques against vaginal simian-human immunodeficiency virus (SHIV) exposures occurring 3 days after gel application, demonstrating long-lasting protection. Despite continued gel dosing postinfection, neither breakthrough infection had evidence of drug resistance by ultrasensitive testing of SHIV in plasma and vaginal lavage. Analysis of the active intracellular tenofovir diphosphate (TFV-DP) in vaginal lymphocytes collected 4 h to 3 days after gel dosing persistently showed high TFV-DP levels (median, 1,810 fmol/10(6) cells) between 4 and 24 h that exceed the 95% inhibitory concentration (IC(95)), reflecting rapid accumulation and long persistence. In contrast to those in peripheral blood mononuclear cells (PBMCs) following oral dosing, TFV-DP levels in vaginal lymphocytes decreased approximately 7-fold by 3 days, exhibiting a much higher rate of decay. We observed a strong correlation between intracellular TFV-DP in vaginal lymphocytes, in vitro antiviral activity, and in vivo protection, suggesting that TFV-DP above the in vitro IC(95) in vaginal lymphocytes is a good predictor of high efficacy. Data from this model reveal an extended window of protection by TFV gel that supports coitus-independent use. The identification of protective TFV-DP concentrations in vaginal lymphocytes may facilitate the evaluation of improved delivery methods of topical TFV and inform clinical studies. C1 [Dobard, Charles; Sharma, Sunita; Martin, Amy; Pau, Chou-Pong; Holder, Angela; Kuklenyik, Zsuzsanna; Lipscomb, Jonathan; Smith, James; Garcia-Lerma, J. Gerardo; Heneine, Walid] Ctr Dis Control & Prevent, Lab Branch, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. [Hanson, Debra L.] Ctr Dis Control & Prevent, Quantitat Sci & Data Management Branch, Div HIV AIDS Prevent, Atlanta, GA USA. [Novembre, Francis J.] Emory Univ, Yerkes Primate Ctr, Atlanta, GA 30322 USA. RP Heneine, W (reprint author), Ctr Dis Control & Prevent, Lab Branch, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. EM wmh2@cdc.gov FU CDC [Y1-AI-0681-02]; NIH [Y1-AI-0681-02] FX This work was partially supported by Interagency Agreement Y1-AI-0681-02 between CDC and NIH. NR 40 TC 59 Z9 59 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD JAN PY 2012 VL 86 IS 2 BP 718 EP 725 DI 10.1128/JVI.05842-11 PG 8 WC Virology SC Virology GA 870MW UT WOS:000298674600007 PM 22072766 ER PT J AU Lindesmith, LC Debbink, K Swanstrom, J Vinje, J Costantini, V Baric, RS Donaldson, EF AF Lindesmith, Lisa C. Debbink, Kari Swanstrom, Jesica Vinje, Jan Costantini, Veronica Baric, Ralph S. Donaldson, Eric F. TI Monoclonal Antibody-Based Antigenic Mapping of Norovirus GII.4-2002 SO JOURNAL OF VIROLOGY LA English DT Article ID NORWALK VIRUS-INFECTION; BLOOD GROUP ANTIGENS; P2 DOMAIN; EPOCHAL EVOLUTION; HUMAN-POPULATIONS; GENETIC-ANALYSIS; HERD-IMMUNITY; UNITED-STATES; GASTROENTERITIS; OUTBREAKS AB Noroviruses are the primary cause of epidemic gastroenteritis in humans, and GII.4 strains cause similar to 80% of the overall disease burden. Surrogate neutralization assays using sera and mouse monoclonal antibodies (MAbs) suggest that antigenic variation maintains GII.4 persistence in the face of herd immunity, as the emergence of new pandemic strains is accompanied by newly evolved neutralization epitopes. To potentially identify specific blockade epitopes that are likely neutralizing and evolving between pandemic strains, mice were hyperimmunized with GII.4-2002 virus-like particles (VLPs) and the resulting MAbs were characterized by biochemical and immunologic assays. All of the MAbs but one recognized GII.4 VLPs representing strains circulating from 1987 to 2009. One MAb weakly recognized GII.4-1987 and -1997 while strongly interacting with 2002 VLPs. This antibody was highly selective and effective at blocking only GII.4-2002-ligand binding. Using bioinformatic analyses, we predicted an evolving GII.4 surface epitope composed of amino acids 407, 412, and 413 and subsequently built mutant VLPs to test the impact of the epitope on MAb binding and blockade potential. Replacement of the 2002 epitope with the epitopes found in 1987 or 2006 strains either reduced or ablated enzyme immunoassay recognition by the GII.4-2002-specific blockade MAb. These data identify a novel, evolving blockade epitope that may be associated with protective immunity, providing further support for the hypotheses that GII.4 norovirus evolution results in antigenic variation that allows the virus to escape from protective herd immunity, resulting in new epidemic strains. C1 [Lindesmith, Lisa C.; Swanstrom, Jesica; Baric, Ralph S.; Donaldson, Eric F.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA. [Debbink, Kari; Baric, Ralph S.] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC USA. [Vinje, Jan; Costantini, Veronica] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA. RP Baric, RS (reprint author), Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA. EM rbaric@email.unc.edu OI Vinje, Jan/0000-0002-1530-3675; Costantini, Veronica/0000-0002-1532-4345 FU National Institutes of Health National Institute of Allergy and Infectious Diseases [AI056351]; Gillings Innovation Laboratory from the University of North Carolina Gillings School of Global Public Health FX This work was supported by a grant from the National Institutes of Health National Institute of Allergy and Infectious Diseases (AI056351) and a Gillings Innovation Laboratory award from the University of North Carolina Gillings School of Global Public Health. NR 50 TC 45 Z9 46 U1 1 U2 8 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD JAN PY 2012 VL 86 IS 2 BP 873 EP 883 DI 10.1128/JVI.06200-11 PG 11 WC Virology SC Virology GA 870MW UT WOS:000298674600021 PM 22090098 ER PT J AU Kersh, GJ Lambourn, DM Raverty, SA Fitzpatrick, KA Self, JS Akmajian, AM Jeffries, SJ Huggins, J Drew, CP Zaki, SR Massung, RF AF Kersh, Gilbert J. Lambourn, Dyanna M. Raverty, Stephen A. Fitzpatrick, Kelly A. Self, Joshua S. Akmajian, Adrianne M. Jeffries, Steven J. Huggins, Jessica Drew, Clifton P. Zaki, Sherif R. Massung, Robert F. TI Coxiella burnetii Infection of Marine Mammals in the Pacific Northwest, 1997-2010 SO JOURNAL OF WILDLIFE DISEASES LA English DT Article DE Coxiella burnetii; marine mammals; placenta; Q fever ID PHOCA-VITULINA-RICHARDSI; Q-FEVER; WASHINGTON-STATE; SUBSTRUCTURE; CALIFORNIA AB Q fever is a zoonotic disease caused by the bacterium Coxiella burnetii. Humans are commonly exposed via inhalation of aerosolized bacteria derived from the waste products of domesticated sheep and goats, and particularly from products generated during parturition. However, many other species can be infected with C. burnetii, and the host range and full zoonotic potential of C. burnetii is unknown. Two cases of C. burnetii infection in marine mammal placenta have, been reported, but it is not known if this infection is common in marine mammals. To address this issue, placenta samples were collected from :Pacific harbor seals (Phoca vitulina richardsi), harbor porpoises (Phocoeno phocoena), and Steller sea lions (Eumetopias photos). Coxiella burnetii was detected by polymerase chain reaction (PCR) in the placentas of Pacific harbor seals (17/27), harbor porpoises (2/6), and Steller sea lions (1/2) collected in the Pacific Northwest. A serosurvey of 215 Pacific harbor seals sampled in inland and outer coastal areas of the Pacific Northwest showed that 34.0% (73/215) had antibodies against either Phase 1 or Phase 2 C. burnetii. These results suggest that C. burnetii infection is common among marine mammals in this region. C1 [Kersh, Gilbert J.; Fitzpatrick, Kelly A.; Self, Joshua S.; Massung, Robert F.] Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Atlanta, GA 30333 USA. [Lambourn, Dyanna M.; Akmajian, Adrianne M.; Jeffries, Steven J.] Washington Dept Fish & Wildlife, Lakewood, WA 98498 USA. [Raverty, Stephen A.] Minist Agr Food & Fisheries, Abbotsford, BC V3G 2M3, Canada. [Huggins, Jessica] Cascadia Res Collect, Olympia, WA 98501 USA. [Drew, Clifton P.; Zaki, Sherif R.] Ctr Dis Control & Prevent, Infect Dis Pathol Branch, Atlanta, GA 30333 USA. RP Kersh, GJ (reprint author), Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, 1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM gkersh@cdc.gov NR 11 TC 10 Z9 10 U1 1 U2 17 PU WILDLIFE DISEASE ASSOC, INC PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA SN 0090-3558 J9 J WILDLIFE DIS JI J. Wildl. Dis. PD JAN PY 2012 VL 48 IS 1 BP 201 EP 206 PG 6 WC Veterinary Sciences SC Veterinary Sciences GA 876VW UT WOS:000299136800025 PM 22247392 ER PT J AU DeGue, S Holt, MK Massetti, GM Matjasko, JL Tharp, AT Valle, LA AF DeGue, Sarah Holt, Melissa K. Massetti, Greta M. Matjasko, Jennifer L. Tharp, Andra Teten Valle, Linda Anne TI Looking Ahead Toward Community-Level Strategies to Prevent Sexual Violence SO JOURNAL OF WOMENS HEALTH LA English DT Article ID COLLEGE CAMPUSES; PUBLIC-HEALTH; ASSAULT; INTERVENTION; ALLIES; POLICY; WOMEN; RAPE; MEN AB The Division of Violence Prevention within CDC's National Center for Injury Prevention and Control recently undertook a systematic review of primary prevention strategies for sexual violence (SV) perpetration. This review identified the lack of community-level strategies to prevent SV as a critical gap in the literature. Community-level strategies function by modifying the characteristics of settings (e. g., schools, workplaces, neighborhoods) that increase the risk for violence victimization and perpetration. Identification of evidence-based strategies at the community level would allow implementation of ecologic approaches to SV prevention with a greater potential for reducing the prevalence of SV perpetration. The field will face several challenges in identifying and evaluating the effectiveness of promising community-level strategies to prevent SV. These challenges include limited knowledge of community-level and societal-level risk factors for SV, a lack of theoretical or empirical guidance in the SV literature for identification of promising community-level approaches, and challenges in evaluating SV outcomes at the community level. Recognition of these challenges should guide future research and foster dialogue within the SV prevention field. The development and evaluation of community-level approaches to SV prevention represent a vital and logical next step toward the implementation of effective, multilevel prevention efforts and a population-level reduction in the prevalence of SV. C1 [DeGue, Sarah; Holt, Melissa K.; Massetti, Greta M.; Matjasko, Jennifer L.; Tharp, Andra Teten; Valle, Linda Anne] Ctr Dis Control & Prevent, Div Violence Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA. RP DeGue, S (reprint author), CDC Div Violence Prevent, 4770 Buford Highway NE,MS F-64, Atlanta, GA 30341 USA. EM sdegue@cde.gov OI Massetti, Greta/0000-0002-3813-9839 NR 24 TC 13 Z9 13 U1 2 U2 20 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 J9 J WOMENS HEALTH JI J. Womens Health PD JAN PY 2012 VL 21 IS 1 BP 1 EP 3 DI 10.1089/jwh.2011.3263 PG 3 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA 876UZ UT WOS:000299134500001 PM 22185587 ER PT J AU Watson-Johnson, LC Townsend, JS Basile, KC Richardson, LC AF Watson-Johnson, Lisa C. Townsend, Julie S. Basile, Kathleen C. Richardson, Lisa C. TI Cancer Screening and History of Sexual Violence Victimization Among US Adults SO JOURNAL OF WOMENS HEALTH LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; NORTH-CAROLINA WOMEN; CERVICAL-CANCER; BREAST-CANCER; PHYSICAL HEALTH; SUBSTANCE USE; ASSAULT; TRAUMA; RISK; PREVALENCE AB Background: Little is known about the effect a history of sexual violence (SV) victimization has on the likelihood of reporting screening tests for cancer. This study investigates the association between SV victimization and cancer screening behaviors. Methods: We analyzed data from the 2006 Behavioral Risk Factor Surveillance System (BRFSS) from 11 states and 1 territory (U.S. Virgin Islands) that administered the SV module to describe demographic characteristics, quality of life, health status, cancer screening behaviors, healthcare coverage, and use of healthcare services for 58,665 women and men who reported SV victimization compared to women and men who did not. The SV victimization measure includes unwanted touching, exposure to sexual material, or ever experiencing completed or attempted unwanted sex. Statistical significance was determined using chi-square tests and multivariate logistic regression models. Results: Multivariate logistic regression results presented as adjusted proportions showed SV victimization was significantly associated with mammography screening for women (74.0 % victims vs. 77.1% nonvictims, p = 0.02). SV victimization was not associated with cancer screening among men. Fewer women reporting SV victimization had healthcare insurance, a personal doctor or healthcare provider, and received regular checkups within the past 1-12 months. Fewer men reporting SV victimization had healthcare coverage. Conclusions: These data suggest that SV victimization may have a negative association on overall healthcare use, including breast cancer screening for women. Healthcare providers should consider SV victimization as a potential barrier for women who report not being up-to-date with mammography. C1 [Watson-Johnson, Lisa C.; Townsend, Julie S.; Richardson, Lisa C.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Basile, Kathleen C.] Ctr Dis Control & Prevent, Div Violence Prevent, Natl Ctr Injury Prevent, Atlanta, GA 30341 USA. RP Richardson, LC (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,MS K-52, Atlanta, GA 30341 USA. EM lfr8@cdc.gov NR 46 TC 5 Z9 5 U1 0 U2 3 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 J9 J WOMENS HEALTH JI J. Womens Health PD JAN PY 2012 VL 21 IS 1 BP 17 EP 25 DI 10.1089/jwh.2011.2751 PG 9 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA 876UZ UT WOS:000299134500004 PM 22011207 ER PT J AU Mitchell, EW Levis, DM Prue, CE AF Mitchell, Elizabeth W. Levis, Denise M. Prue, Christine E. TI Preconception Health: Awareness, Planning, and Communication Among a Sample of US Men and Women SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Preconception; Pregnancy; Knowledge; Awareness; Communication ID NEWLY MARRIED-COUPLES; UNITED-STATES; COMMUNITY SAMPLE; CARE; PREGNANCY; RECOMMENDATIONS; PREVENTION; BEHAVIORS; SERVICES; OUTCOMES AB It is important to educate both men and women about preconception health (PCH), but limited research exists in this area. This paper examines men's and women's awareness of exposure to PCH information and of specific PCH behaviors, PCH planning, and PCH discussions with their partners. Data from Porter Novelli's 2007 Healthstyles survey were used. Women and men of reproductive age were included in the analysis (n = 2,736) to understand their awareness, planning, and conversations around PCH. Only 27.9% of women and men reported consistently using an effective birth control method. The majority of men (52%) and women (43%) were unaware of any exposure to PCH messages; few received information from their health care provider. Women were more aware than men of specific pre-pregnancy health behaviors. Women in the sample reported having more PCH conversations with their partners than did men. PCH education should focus on both women and men. Communication about PCH is lacking, both between couples and among men and women and their health care providers. PCH education might benefit from brand development so that consumers know what to ask for and providers know what to deliver. C1 [Mitchell, Elizabeth W.; Levis, Denise M.] Ctr Dis Control & Prevent, Prevent Res Branch, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Levis, Denise M.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Prue, Christine E.] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. RP Mitchell, EW (reprint author), Ctr Dis Control & Prevent, Prevent Res Branch, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. EM bhm0@cdc.gov NR 37 TC 17 Z9 19 U1 2 U2 11 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD JAN PY 2012 VL 16 IS 1 BP 31 EP 39 DI 10.1007/s10995-010-0663-y PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 875AL UT WOS:000299001100004 PM 20734124 ER PT J AU Bombard, JM Dietz, PM Galavotti, C England, LJ Tong, VT Hayes, DK Morrow, B AF Bombard, Jennifer M. Dietz, Patricia M. Galavotti, Christine England, Lucinda J. Tong, Van T. Hayes, Donald K. Morrow, Brian TI Chronic Diseases and Related Risk Factors among Low-Income Mothers SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Pregnancy; Chronic diseases; Prevalence; Poverty ID MONITORING-SYSTEM PRAMS; GESTATIONAL WEIGHT-GAIN; BINGE DRINKING; UNITED-STATES; CARDIOVASCULAR-DISEASE; POSTPARTUM DEPRESSION; ALCOHOL-CONSUMPTION; ADULT OUTCOMES; FOLLOW-UP; PREGNANCY AB The aim is to describe the burden of chronic disease and related risk factors among low-income women of reproductive age. We analyzed population-based data from the 2005-2006 Pregnancy Risk Assessment Monitoring System (PRAMS) for 14,990 women with a live birth in 7 states. We examined the prevalence of selected chronic diseases and related risk factors (preexisting diabetes, gestational diabetes, chronic hypertension, pregnancy-induced hypertension, obesity, smoking or binge drinking prior to pregnancy, smoking or excessive weight gain during pregnancy, and postpartum depressive symptoms) by Federal Poverty Level (FPL) (a parts per thousand currency sign100% FPL; 101-250% FPL; > 250% FPL). Approximately one-third of women were low-income (a parts per thousand currency sign100% FPL), one-third were near-low-income (101-250% FPL), and one-third were higher-income (> 250% FPL). Compared to higher-income women, low-income women were significantly more likely to smoke before or during pregnancy (34.2% vs. 14.4%, and 24.8% vs. 5.4%, respectively), be obese (22.2% vs. 16.0%), experience postpartum depressive symptoms (23.3% vs. 7.9%), have 3 or more chronic diseases and/or related risk factors (28.1% vs. 14.4%) and be uninsured before pregnancy (48.9% vs. 4.8%). Low-income women of reproductive age experienced a higher prevalence of selected chronic diseases and related risk factors. Enhancing services for these women in publicly-funded family planning clinics may help reduce disparities in pregnancy and long-term health outcomes in the poor. C1 [Bombard, Jennifer M.; Dietz, Patricia M.; Galavotti, Christine; Tong, Van T.; Hayes, Donald K.; Morrow, Brian] Ctr Dis Control & Prevent, Appl Sci Branch, Div Reprod Hlth, Natl Ctr Chron Dis & Hlth Promot, Atlanta, GA 30341 USA. [England, Lucinda J.] Ctr Dis Control & Prevent, Maternal & Infant Branch, Div Reprod Hlth, Natl Ctr Chron Dis & Hlth Promot, Atlanta, GA 30341 USA. RP Bombard, JM (reprint author), Ctr Dis Control & Prevent, Appl Sci Branch, Div Reprod Hlth, Natl Ctr Chron Dis & Hlth Promot, 4770 Buford Highway,MS K-22, Atlanta, GA 30341 USA. EM jbombard@cdc.gov; pdietz@cdc.gov; cgalavotti@care.org; lengland@cdc.gov; vtong@cdc.gov; dhayes@cdc.gov; bmorrow@cdc.gov OI Tong, Van/0000-0002-3970-1440 NR 51 TC 10 Z9 10 U1 2 U2 6 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD JAN PY 2012 VL 16 IS 1 BP 60 EP 71 DI 10.1007/s10995-010-0717-1 PG 12 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 875AL UT WOS:000299001100007 PM 21153761 ER PT J AU Schiefelbein, EL Mirchandani, GG George, GC Becker, EA Castrucci, BC Hoelscher, DM AF Schiefelbein, Emily L. Mirchandani, Gita G. George, Goldy C. Becker, Emilie A. Castrucci, Brian C. Hoelscher, Deanna M. TI Association Between Depressed Mood and Perceived Weight in Middle and High School Age Students: Texas 2004-2005 SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Adolescent; Body weight; Weight perception; Overweight; Obesity; Depression ID BODY-MASS INDEX; MENTAL-HEALTH OUTCOMES; ADOLESCENT GIRLS; RISK-FACTORS; CLINICAL-IMPLICATIONS; GENDER-DIFFERENCES; YOUNG ADOLESCENTS; PHYSICAL-ACTIVITY; OVERWEIGHT STATUS; UNITED-STATES AB Research exploring the relationship between weight perception and depressed mood among adolescents is limited in the United States. The purpose of this study is to examine the association of perceived versus actual body weight and depressed mood in a representative sample of 8th and 11th grade public school students in Texas. Using data from the 2004-2005 School Physical Activity and Nutrition (SPAN) study, logistic regression analyses were conducted to assess the association of weight perception with depressed mood. Healthy weight students who perceived themselves to be a healthy weight were the reference group for all analyses. A high prevalence of misperception of body weight was observed. Overweight and obese 8th grade girls and boys who perceived themselves to be overweight had increased odds of depressed mood [Girls: OR 1.70 (95% CI: 1.07-2.69), Boys: OR 2.05 (95% CI: 1.16-3.62)]. Healthy weight 8th grade girls who perceived themselves to be overweight had 2.5 times greater odds of depressed mood (OR 2.63, 95% CI: 1.54-4.50). Healthy weight boys who perceived themselves to be underweight had more than twice the odds (OR 2.18, 95% CI: 1.23-3.89) of depressed mood. No weight category was significantly associated with depressed mood in boys or girls in 11th grade. The present study suggests that weight misperceptions are associated with depressed mood in young adolescents. Education about healthy body size is necessary to correct the common weight misperceptions observed. The high prevalence rates of depressed mood suggest a greater need for research into understanding factors that may contribute to depressed mood in adolescents. C1 [Schiefelbein, Emily L.] Ctr Dis Control & Prevent, CDC CSTE Appl Epidemiol Fellowship Program, Div Family & Community Hlth Serv, Council State & Terr Epidemiologists,Texas Dept S, Austin, TX 78714 USA. [George, Goldy C.] NCI, Bethesda, MD 20892 USA. [George, Goldy C.] Univ Texas Sch Publ Hlth, Michael & Susan Dell Ctr Adv Hlth Living, Houston, TX USA. [Becker, Emilie A.] Texas Dept State Hlth Serv, Div Mental Hlth & Subst Abuse, Austin, TX USA. [Castrucci, Brian C.] Georgia Dept Publ Hlth, Maternal & Child Hlth Program, Austin, TX USA. [Hoelscher, Deanna M.] Univ Texas Sch Publ Hlth Austin, Michael & Susan Dell Ctr Adv Hlth Living, Austin, TX USA. RP Schiefelbein, EL (reprint author), Ctr Dis Control & Prevent, CDC CSTE Appl Epidemiol Fellowship Program, Div Family & Community Hlth Serv, Council State & Terr Epidemiologists,Texas Dept S, MC 1922,POB 149347, Austin, TX 78714 USA. EM Emily.schiefelbein@gmail.com; gita.mirchandani@dshs.state.tx.us; goldyjg@yahoo.com; emilie.becker@dshs.state.tx.us; brian.castrucci@gmail.com; deanna.m.hoelscher@uth.tmc.edu FU NCHM CDC HHS [5U38HM000414] NR 49 TC 5 Z9 5 U1 0 U2 1 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD JAN PY 2012 VL 16 IS 1 BP 169 EP 176 DI 10.1007/s10995-010-0733-1 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 875AL UT WOS:000299001100019 PM 21165762 ER PT J AU Nowakowski, L Barfield, WD Kroelinger, CD Lauver, CB Lawler, MH White, VA Ramos, LR AF Nowakowski, Lindsey Barfield, Wanda D. Kroelinger, Charlan D. Lauver, Cassie B. Lawler, Michele H. White, Vanessa A. Ramos, Lauren Raskin TI Assessment of State Measures of Risk-Appropriate Care for Very Low Birth Weight Infants and Recommendations for Enhancing Regionalized State Systems SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Perinatal regionalization; Risk-appropriate care; Very low birth weight infants; Neonatal levels of care ID NEONATAL-MORTALITY; PRETERM INFANTS; LEVEL; VOLUME AB The goal of this study was to examine state measurements and improvements in risk-appropriate care for very low birth weight (VLBW) infants. The authors reviewed state perinatal regionalization models and levels of care to compare varying definitions between states and assess mechanisms of measurement and areas for improvement. Seven states that presented at a 2009 Association of Maternal & Child Health Programs Perinatal Regionalization Meeting were included in the assessment. Information was gathered from meeting presentations, presenters, state representatives, and state websites. Comparison of state levels of care and forms of regulation were outlined. Review of state models revealed variability in the models themselves, as well as the various mechanisms for measuring and improving risk-appropriate care. Regulation of regionalization programs, data surveillance, review of adverse events, and consideration of geography and demographics were identified as mechanisms facilitating better measurement of risk-appropriate care. Antenatal or neonatal transfer arrangements, telemedicine networks, acquisition of funding, provision of financial incentives, and patient education comprised state actions for improving risk-appropriate care. The void of explicit and updated national standards led to the current variations in definitions and models among states. State regionalization models and measures of risk-appropriate care varied greatly. These variations arose from inconsistent definitions and models of perinatal regionalization. Guidelines should be collaboratively developed by healthcare providers and public health officials for consistent and suitable measures of perinatal risk-appropriate care. C1 [Barfield, Wanda D.; Kroelinger, Charlan D.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Nowakowski, Lindsey] Med Coll Georgia, Sch Med, Augusta, GA 30912 USA. [Lauver, Cassie B.; Lawler, Michele H.] Maternal & Child Hlth Bur, US Dept Hlth & Human Serv, Hlth Resources & Serv Adm, Rockville, MD USA. [White, Vanessa A.; Ramos, Lauren Raskin] Assoc Maternal & Child Hlth Programs, Washington, DC USA. RP Barfield, WD (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,MS K-20, Atlanta, GA 30341 USA. EM wbarfield@cdc.gov NR 42 TC 7 Z9 7 U1 1 U2 7 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD JAN PY 2012 VL 16 IS 1 BP 217 EP 227 DI 10.1007/s10995-010-0721-5 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 875AL UT WOS:000299001100025 PM 21181248 ER PT J AU Machain-Williams, C Mammen, MP Zeidner, NS Beaty, BJ Prenni, JE Nisalak, A Blair, CD AF Machain-Williams, C. Mammen, M. P., Jr. Zeidner, N. S. Beaty, B. J. Prenni, J. E. Nisalak, A. Blair, C. D. TI Association of human immune response to Aedes aegypti salivary proteins with dengue disease severity SO PARASITE IMMUNOLOGY LA English DT Article DE Aedes aegypti; dengue; dengue haemorrhagic fever; mosquito salivary proteins ID YELLOW-FEVER MOSQUITO; VON-WILLEBRAND-FACTOR; NILE-VIRUS-INFECTION; ANOPHELES-STEPHENSI; WEST-NILE; CUTANEOUS LEISHMANIASIS; JAPANESE ENCEPHALITIS; ARTHROPOD SALIVA; IGG4 ANTIBODIES; BITES AB Dengue viruses (DENV; family Flaviviridae, genus Flavivirus) are transmitted by Aedes aegypti mosquitoes and can cause dengue fever (DF), a relatively benign disease, or more severe dengue haemorrhagic fever (DHF). Arthropod saliva contains proteins delivered into the bite wound that can modulate the host haemostatic and immune responses to facilitate the intake of a blood meal. The potential effects on DENV infection of previous exposure to Ae.similar to aegypti salivary proteins have not been investigated. We collected Ae.similar to aegypti saliva, concentrated the proteins and fractionated them by nondenaturing polyacrylamide gel electrophoresis (PAGE). By the use of immunoblots, we analysed reactivity with the mosquito salivary proteins (MSP) of sera from 96 Thai children diagnosed with secondary DENV infections leading either to DF or DHF, or with no DENV infection, and found that different proportions of each patient group had serum antibodies reactive to specific Ae similar to aegypti salivary proteins. Our results suggest that prior exposure to MSP might play a role in the outcome of DENV infection in humans. C1 [Machain-Williams, C.; Beaty, B. J.; Blair, C. D.] Colorado State Univ, Dept Microbiol Immunol & Pathol, Arthropod Borne & Infect Dis Lab, Ft Collins, CO 80523 USA. [Zeidner, N. S.; Nisalak, A.] Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Zeidner, N. S.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA. [Prenni, J. E.] Colorado State Univ, Prote & Metabol Facil, Ft Collins, CO 80523 USA. RP Blair, CD (reprint author), Colorado State Univ, Dept Microbiol Immunol & Pathol, Arthropod Borne & Infect Dis Lab, Ft Collins, CO 80523 USA. EM carlos.machain@uady.mx; carol.blair@colostate.edu OI Prenni, Jessica/0000-0002-0337-8450 FU U.S Medical Research and Materiel Command; National Institutes of Health, USA [N01 AI25489] FX We are grateful to Dr. Jill Troyer, Walter Reed Army Institute of Research, for making the serum samples available at the Arthropod-borne and Infectious Diseases Laboratory. We thank Dr. James zumBrunnen, Department of Statistics, Colorado State University, for his help in the statistical analysis of the data presented in this work. This work was supported in part by a grant from the U.S Medical Research and Materiel Command (MPM and AN) and by National Institutes of Health, USA, contract N01 AI25489 (BJB and CDB). NR 49 TC 17 Z9 20 U1 2 U2 14 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0141-9838 J9 PARASITE IMMUNOL JI Parasite Immunol. PD JAN PY 2012 VL 34 IS 1 BP 15 EP 22 DI 10.1111/j.1365-3024.2011.01339.x PG 8 WC Immunology; Parasitology SC Immunology; Parasitology GA 869JK UT WOS:000298594000003 PM 21995849 ER PT J AU Coughlin, MM Prabhakar, BS AF Coughlin, Melissa M. Prabhakar, Bellur S. TI Neutralizing human monoclonal antibodies to severe acute respiratory syndrome coronavirus: target, mechanism of action, and therapeutic potential SO REVIEWS IN MEDICAL VIROLOGY LA English DT Review ID SYNDROME (SARS)-ASSOCIATED CORONAVIRUS; SARS-ASSOCIATED CORONAVIRUS; RECEPTOR-BINDING DOMAIN; ANGIOTENSIN-CONVERTING ENZYME-2; IN-SITU HYBRIDIZATION; SPIKE PROTEIN; S-PROTEIN; DC-SIGN; STRUCTURAL-CHARACTERIZATION; PROTECTIVE IMMUNITY AB The emergence of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) led to a rapid response not only to contain the outbreak but also to identify possible therapeutic interventions, including the generation of human monoclonal antibodies (hmAbs). hmAbs may be used therapeutically without the drawbacks of chimeric or animal Abs. Several different methods have been used to generate SARS-CoV specific neutralizing hmAbs including the immunization of transgenic mice, cloning of small chain variable regions from naive and convalescent patients, and the immortalization of convalescent B cells. Irrespective of the techniques used, the majority of hmAbs specifically reacted with the receptor binding domain (RBD) of the spike (S) protein and likely prevented receptor binding. However, several hmAbs that can bind to epitopes either within the RBD, located N terminal of the RBD or in the S2 domain, and neutralize the virus with or without inhibiting receptor binding have been identified. Therapeutic utility of hmAbs has been further elucidated through the identification of potential combinations of hmAbs that could neutralize viral variants including escape mutants selected using hmAbs. These results suggest that a cocktail of hmAbs that can bind to unique epitopes and have different mechanisms of action might be of clinical utility against SARS-CoV infection, and indicate that a similar approach may be applied to treat other viral infections. Copyright (c) 2011 John Wiley & Sons, Ltd. C1 [Prabhakar, Bellur S.] Univ Illinois, Coll Med, Dept Microbiol & Immunol, Chicago, IL 60612 USA. [Coughlin, Melissa M.] Ctr Dis Control & Prevent, Measles Mumps Rubella & Herpes Virus Lab Branch, Atlanta, GA USA. RP Prabhakar, BS (reprint author), Univ Illinois, Coll Med, Dept Microbiol & Immunol, MC790,Room E705,835 S Wolcott Ave, Chicago, IL 60612 USA. EM bprabhak@uic.edu FU NIH [1U01AI077921-01] FX We would like to thank Dr. Paul Rota for critical review of this manuscript. This work was supported by NIH grant 1U01AI077921-01 to BP. NR 94 TC 10 Z9 11 U1 0 U2 7 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1052-9276 J9 REV MED VIROL JI Rev. Med. Virol. PD JAN PY 2012 VL 22 IS 1 BP 2 EP 17 DI 10.1002/rmv.706 PG 16 WC Virology SC Virology GA 874HB UT WOS:000298944900002 PM 21905149 ER PT J AU Levin, ML Killmaster, LF Zemtsova, GE AF Levin, Michael L. Killmaster, Lindsay F. Zemtsova, Galina E. TI Domestic Dogs (Canis familiaris) as Reservoir Hosts for Rickettsia conorii SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Dog; Mediterranean spotted fever; Reservoir; Rickettsia conorii; Rhipicephalus sanguineus ID MEDITERRANEAN SPOTTED-FEVER; RHIPICEPHALUS-SANGUINEUS; EXPERIMENTAL-INFECTION; BOUTONNEUSE FEVER; TICKS; SPAIN; TRANSMISSION; ANTIBODIES; IXODIDAE; ISRAEL AB Rickettsia conorii is the causative agent of Mediterranean spotted fever (MSF) and Israeli spotted fever (ISF) transmitted by the brown dog tick Rhipicephalus sanguineus. In areas where MSF or ISF are prevalent, dogs have high prevalence of R. conorii-neutralizing antibodies. However, the true role of dogs in the persistence of the R. conorii transmission cycle is unknown, and their reservoir competence for this pathogen has remained untested. We assessed the ability of dogs infected with R. conorii to transmit the pathogen to previously uninfected Rh. sanguineus ticks. Dogs were infected either via needle-inoculation of cultured rickettsiae or naturally via infected tick bite. Dogs were monitored for clinical signs of infection, for rickettsemia by PCR, and for seroconversion and were subjected to infestation with uninfected ticks at different time points. Rh. sanguineus larvae and nymphs successfully acquired the agent from both needle-inoculated and tick-infected dogs and transmitted it transtadially. Tick-infected dogs remained infectious to ticks for at least a month postinfection. The molted ticks were, in turn, infectious to naive dogs. These results demonstrate that dogs are capable of acquiring R. conorii from infected Rh. sanguineus ticks and transmitting infection to cohorts of uninfected ticks, thus confirming for the first time that dogs are indeed competent reservoirs for R. conorii. In addition, dogs with different genetic backgrounds appear to differ in their susceptibility to R. conorii infection. C1 [Levin, Michael L.; Killmaster, Lindsay F.; Zemtsova, Galina E.] Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Atlanta, GA 30333 USA. RP Levin, ML (reprint author), Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, 1600 Clifton Rd,MS G-13, Atlanta, GA 30333 USA. EM mlevin@cdc.gov NR 34 TC 28 Z9 28 U1 2 U2 10 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD JAN PY 2012 VL 12 IS 1 BP 28 EP 33 DI 10.1089/vbz.2011.0684 PG 6 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 876MY UT WOS:000299112800005 PM 21923270 ER PT J AU Komar, N Bessoff, K Diaz, A Amador, M Young, G Seda, R Perez, T Hunsperger, E AF Komar, Nicholas Bessoff, Kovi Diaz, Annette Amador, Manuel Young, Ginger Seda, Rafael Perez, Taonex Hunsperger, Elizabeth TI Avian Hosts of West Nile Virus in Puerto Rico SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Arbovirus; Bird; Ecology; Mosquito; Reservoir host; West Nile virus; Zoonotic disease ID SEROLOGIC EVIDENCE; TRANSMISSION; BIRDS; AMPLIFICATION; ANTIBODIES AB West Nile virus (WNV) ecology in neotropical ecosystems is poorly understood, and vertebrate hosts responsible for infecting mosquitoes remain unidentified throughout the Caribbean Basin. After a period of intense WNV transmission among sentinel chickens near Ceiba, Puerto Rico, we measured abundance of resident birds and species-specific prevalence of WNV infection. Taking the product of these measures indicates the relative number of WNV infections by species. Greater Antillean grackle (Quiscalus niger) accounted for the most WNV infections among birds in our 100-km(2) study site. In urban habitats, the house sparrow (Passer domesticus) was frequently infected. Immature birds less than one year of age were more likely to have detectable WNV-reactive antibodies than older birds of the same species. C1 [Komar, Nicholas; Young, Ginger] Ctr Dis Control & Prevent CDC, ADB, DVBD, Ft Collins, CO 80521 USA. [Bessoff, Kovi; Diaz, Annette; Amador, Manuel; Hunsperger, Elizabeth] CDC, DB, DVBD, San Juan, PR USA. [Seda, Rafael; Perez, Taonex] Puerto Rico Dept Hlth, San Juan, PR USA. RP Komar, N (reprint author), Ctr Dis Control & Prevent CDC, ADB, DVBD, 3150 Rampart Rd, Ft Collins, CO 80521 USA. EM nkomar@cdc.gov FU Centers for Disease Control and Prevention FX Numerous private property owners granted permission for field studies, in particular the managers of the Roosevelt Roads Naval Base. Veronica Acevedo, Heidi Acosta, Manuela Beltran, Kali Shaw, and others provided field assistance and laboratory support. Josh Dooley assisted with data analysis. Mark Delorey provided statistical advice. Roberto Barrera provided the aerial image of the study region. Animals were handled in this study following the guidelines of the Public Health Service and National Research Council, and approved by the Institutional Animal Care and Use Committee of CDC-DVBD. This work was funded by the Centers for Disease Control and Prevention. Support for employees of the Puerto Rico Department of Health was administered through a Cooperative Agreement. The statements and opinions expressed in this article are those of the authors and do not necessarily represent the official policy of the Centers for Disease Control and Prevention or the U.S. Government or the Government of the Commonwealth of Puerto Rico. NR 27 TC 4 Z9 4 U1 0 U2 10 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD JAN PY 2012 VL 12 IS 1 BP 47 EP 54 DI 10.1089/vbz.2011.0609 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 876MY UT WOS:000299112800008 PM 21923260 ER PT J AU Rahman, MA Hossain, MJ Sultana, S Homaira, N Khan, SU Rahman, M Gurley, ES Rollin, PE Lo, MK Comer, JA Lowe, L Rota, PA Ksiazek, TG Kenah, E Sharker, Y Luby, SP AF Rahman, Muhammad Aziz Hossain, Mohammad Jahangir Sultana, Sharmin Homaira, Nusrat Khan, Salah Uddin Rahman, Mahmudur Gurley, Emily S. Rollin, Pierre E. Lo, Michael K. Comer, James A. Lowe, Luis Rota, Paul A. Ksiazek, Thomas G. Kenah, Eben Sharker, Yushuf Luby, Stephen P. TI Date Palm Sap Linked to Nipah Virus Outbreak in Bangladesh, 2008 SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Bats; Epidemiology; Surveillance; Transmission; Zoonosis ID FLYING-FOXES; TRANSMISSION; INFECTION; BATS; INDIA AB Introduction: We investigated a cluster of patients with encephalitis in the Manikgonj and Rajbari Districts of Bangladesh in February 2008 to determine the etiology and risk factors for disease. Methods: We classified persons as confirmed Nipah cases by the presence of immunoglobulin M antibodies against Nipah virus (NiV), or by the presence of NiV RNA or by isolation of NiV from cerebrospinal fluid or throat swabs who had onset of symptoms between February 6 and March 10, 2008. We classified persons as probable cases if they reported fever with convulsions or altered mental status, who resided in the outbreak areas during that period, and who died before serum samples were collected. For the case-control study, we compared both confirmed and probable Nipah case-patients to controls, who were free from illness during the reference period. We used motion-sensor-infrared cameras to observe bat's contact of date palm sap. Results: We identified four confirmed and six probable case-patients, nine (90%) of whom died. The median age of the cases was 10 years; eight were males. The outbreak occurred simultaneously in two communities that were 44km apart and separated by a river. Drinking raw date palm sap 2-12 days before illness onset was the only risk factor most strongly associated with the illness (adjusted odds ratio 25, 95% confidence intervals 3.3-infinity, p < 0.001). Case-patients reported no history of physical contact with bats, though community members often reported seeing bats. Infrared camera photographs showed that Pteropus bats frequently visited date palm trees in those communities where sap was collected for human consumption. Conclusion: This is the second Nipah outbreak in Bangladesh where date palm sap has been implicated as the vehicle of transmission. Fresh date palm sap should not be drunk, unless effective steps have been taken to prevent bat access to the sap during collection. C1 [Rahman, Muhammad Aziz; Hossain, Mohammad Jahangir; Homaira, Nusrat; Khan, Salah Uddin; Gurley, Emily S.; Sharker, Yushuf; Luby, Stephen P.] Int Ctr Diarrhoeal Dis Res, Dhaka 1000, Bangladesh. [Rahman, Muhammad Aziz; Sultana, Sharmin; Homaira, Nusrat; Rahman, Mahmudur] Inst Epidemiol Dis Control & Res, Dhaka, Bangladesh. [Rollin, Pierre E.; Lo, Michael K.; Comer, James A.; Lowe, Luis; Rota, Paul A.; Ksiazek, Thomas G.; Luby, Stephen P.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Ksiazek, Thomas G.] Univ Texas Med Branch, Galveston Natl Lab, Dept Pathol, Galveston, TX USA. [Kenah, Eben] Univ Washington, Dept Biostat, Seattle, WA 98195 USA. RP Rahman, MA (reprint author), Univ Adelaide, Discipline Publ Hlth, Level 9,10 Pulteney St, Adelaide, SA 5000, Australia. EM aziz.rahman@adelaide.edu.au RI Gurley, Emily/B-7903-2010; OI Gurley, Emily/0000-0002-8648-9403; Lo, Michael/0000-0002-0409-7896; Rahman, Muhammad Aziz/0000-0003-1665-7966 FU Government of Bangladesh; U.S. Centers for Disease Control and Prevention; IEDCR FX This research activity was funded by the Government of Bangladesh and the U.S. Centers for Disease Control and Prevention. ICDDR,B acknowledges with gratitude the commitment of Government of Bangladesh and the U.S. Centers for Disease Control and Prevention to ICDDR,B's research efforts. We extend thanks to Dr. Imtiaz Ashraf Chowdhury and Dr. Sayma Afroze of IEDCR. Thanks also to Dr. Abu Shahid from Nipah surveillance team at Rajbari District, Dr. Khondker Mahbuba Jamil from IEDCR for laboratory support, Dr. Shahed Sazzad and Mr. Dawlat from ICDDR,B for data collection, and Ms. Dorothy Southern for her support in preparing the article. We also thank the two communities for participating in our study. NR 24 TC 43 Z9 43 U1 0 U2 28 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD JAN PY 2012 VL 12 IS 1 BP 65 EP 72 DI 10.1089/vbz.2011.0656 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 876MY UT WOS:000299112800011 PM 21923274 ER PT J AU Kempe, A Wortley, P O'Leary, S Crane, LA Daley, MF Stokley, S Babbel, C Dong, F Beaty, B Seewald, L Suh, C Dickinson, LM AF Kempe, Allison Wortley, Pascale O'Leary, Sean Crane, Lori A. Daley, Matthew F. Stokley, Shannon Babbel, Christine Dong, Fran Beaty, Brenda Seewald, Laura Suh, Christina Dickinson, L. Miriam TI Pediatricians' Attitudes About Collaborations With Other Community Vaccinators in the Delivery of Seasonal Influenza Vaccine SO ACADEMIC PEDIATRICS LA English DT Article DE immunization delivery; influenza immunization; school immunization ID SCHOOL-AGED CHILDREN; UNITED-STATES; NATIONAL-SURVEY; MONROE COUNTY; NEW-YORK; IMMUNIZATION; SCHOOLCHILDREN; BENEFITS; BURDEN; IMPACT AB OBJECTIVE: Achieving universal influenza vaccination among children may necessitate collaborative delivery involving both practices and community vaccinators. We assessed among pediatricians nationally their preferences regarding location of influenza vaccination for patient subgroups and their attitudes about collaborative delivery methods. METHODS: The design/setting was a national survey conducted from July 2009 to October 2009. Participants included a representative sample of pediatricians from the American Academy of Pediatrics. RESULTS: The response rate was 79% (330 of 416). Physicians felt strongly that vaccination should occur in their practice for children with chronic conditions (52%) and healthy 6-24-month-old infants (48%), but few felt strongly about healthy 5-18-year-olds (17%). Most (78%) thought having multiple delivery sites increased vaccination rates, and 86% thought that influenza vaccine should be available at school. Physicians reported being very/somewhat willing to hold joint community clinics with public health entities (76%) and to suggest to patient subgroups that they receive vaccine at community sites, including public clinics or pharmacies (76%). The most frequently reported barriers to collaborative delivery with community sites or school-located delivery included concerns about the following: estimating the amount of vaccine to order if children are vaccinated elsewhere (community 56%; school 80%); transfer of vaccine records (community 57%; school 78%); and reluctance of families to go outside of the office (community 45%; school 74%). CONCLUSIONS: Most physicians are in favor of school-located or collaborative influenza vaccine delivery with community vaccinators, especially for healthy school-aged children. Collaborative approaches will require planning to ensure transfer of records, effective targeting of subgroups, and provisions to protect providers from being left with extra influenza supply. C1 [Kempe, Allison; O'Leary, Sean; Daley, Matthew F.; Suh, Christina] Univ Colorado Denver, Dept Pediat, Aurora, CO USA. [Dickinson, L. Miriam] Univ Colorado Denver, Dept Family Med, Aurora, CO USA. [Kempe, Allison; Crane, Lori A.] Univ Colorado Denver, Colorado Sch Publ Hlth, Aurora, CO USA. [Kempe, Allison; Daley, Matthew F.; Dong, Fran; Beaty, Brenda] Univ Colorado Denver, Colorado Hlth Outcomes Program, Aurora, CO USA. [Kempe, Allison; O'Leary, Sean; Crane, Lori A.; Daley, Matthew F.; Babbel, Christine; Dong, Fran; Beaty, Brenda; Seewald, Laura; Suh, Christina; Dickinson, L. Miriam] Childrens Hosp, Childrens Outcomes Res Program, Aurora, CO USA. [Wortley, Pascale; Stokley, Shannon] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Kempe, A (reprint author), 1056 E 19th Ave,B032, Denver, CO 80218 USA. EM allison.kempe@childrenscolorado.org FU Centers for Disease Control and Prevention PEP through the Association of American Medical Colleges, Washington, DC [MM-1040-08/08] FX This investigation was funded by a grant from the Centers for Disease Control and Prevention PEP (MM-1040-08/08) through the Association of American Medical Colleges, Washington, DC. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention or the US Department of Health and Human Services. NR 59 TC 15 Z9 15 U1 2 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1876-2859 J9 ACAD PEDIATR JI Acad. Pediatr. PD JAN-FEB PY 2012 VL 12 IS 1 BP 26 EP 35 PG 10 WC Pediatrics SC Pediatrics GA 879VM UT WOS:000299361000007 PM 21900066 ER PT J AU Margolis, AD Joseph, H Belcher, L Hirshfield, S Chiasson, MA AF Margolis, Andrew D. Joseph, Heather Belcher, Lisa Hirshfield, Sabina Chiasson, Mary Ann TI 'Never Testing for HIV' Among Men Who Have Sex with Men Recruited from a Sexual Networking Website, United States SO AIDS AND BEHAVIOR LA English DT Article DE HIV testing; Men who have sex with men; Internet; Sexual networking ID SEROPOSITIVE MEN; RISK; PREVALENCE; RESPONSIBILITY; TRANSMISSION; INFECTION; DIAGNOSIS; BEHAVIOR; ADULTS AB HIV testing was assessed online among men accessing a sexual networking website for men who have sex with men. Most of the 8,040 participants reported HIV testing (58.2% a parts per thousand currency sign 1 year; 33.1% > 1 year) and 17.1% were HIV-positive. Overall, 8.6% of men including 24% of those 18-24 years of age had never been tested. Among never testers, 25% did not know where to get tested. Predictors of never being tested included younger age (18-24), bisexual or heterosexual orientation, living outside of large metropolitan areas, and not having a healthcare provider. Increasing access to and knowledge of HIV testing sites is needed. C1 [Margolis, Andrew D.; Joseph, Heather; Belcher, Lisa] Ctr Dis Control & Prevent, Prevent Res Branch, Div HIV AIDS Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA. [Hirshfield, Sabina; Chiasson, Mary Ann] Publ Hlth Solut, New York, NY USA. RP Margolis, AD (reprint author), Ctr Dis Control & Prevent, Prevent Res Branch, Div HIV AIDS Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, 1600 Clifton Rd,Mail Stop E-37, Atlanta, GA 30333 USA. EM AMargolis@cdc.gov FU NCHHSTP CDC HHS [UR6/PS000415] NR 33 TC 28 Z9 28 U1 2 U2 8 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1090-7165 J9 AIDS BEHAV JI AIDS Behav. PD JAN PY 2012 VL 16 IS 1 BP 23 EP 29 DI 10.1007/s10461-011-9883-4 PG 7 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA 875SI UT WOS:000299054700004 PM 21279431 ER PT J AU Hall, HI Walker, F Shah, D Belle, E AF Hall, H. Irene Walker, Frances Shah, Daxa Belle, Eboni TI Trends in HIV Diagnoses and Testing Among U.S. Adolescents and Young Adults SO AIDS AND BEHAVIOR LA English DT Article DE HIV; Surveillance; Youth ID MEN; SEX; DISPARITIES AB The Centers for Disease Control and Prevention recommends routine HIV screening in health care settings. Using national surveillance data, we assessed trends in HIV diagnoses and testing frequency in youth aged 13-24 diagnosed with HIV in 2005-2008. Diagnosis rates increased among black (17.0% per year), Hispanic (13.5%), and white males (8.8%), with increases driven by men who have sex with men (MSM). A higher percentage of white males and MSM had previously been tested than their counterparts. No increases in diagnoses or differences in testing were observed among females. Intensified interventions are needed to reduce HIV infections and racial/ethnic disparities. C1 [Hall, H. Irene; Walker, Frances; Belle, Eboni] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Shah, Daxa] Northrop Grumman Corp, Atlanta, GA USA. RP Hall, HI (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, MS E-47,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM ixh1@cdc.gov NR 13 TC 17 Z9 17 U1 0 U2 7 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1090-7165 J9 AIDS BEHAV JI AIDS Behav. PD JAN PY 2012 VL 16 IS 1 BP 36 EP 43 DI 10.1007/s10461-011-9944-8 PG 8 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA 875SI UT WOS:000299054700006 PM 21484282 ER PT J AU Kissinger, P Kovacs, S Anderson-Smits, C Schmidt, N Salinas, O Hembling, J Beaulieu, A Longfellow, L Liddon, N Rice, J Shedlin, M AF Kissinger, Patricia Kovacs, Stephanie Anderson-Smits, Colin Schmidt, Norine Salinas, Oscar Hembling, John Beaulieu, Allyson Longfellow, Lisa Liddon, Nicole Rice, Janet Shedlin, Michele TI Patterns and Predictors of HIV/STI Risk Among Latino Migrant Men in a New Receiving Community SO AIDS AND BEHAVIOR LA English DT Article DE HIV; Sexually transmitted diseases; Migrants; Latinos; Respondent driven sampling ID MEXICAN MIGRANTS; NORTH-CAROLINA; UNITED-STATES; MOBILE POPULATIONS; HISPANIC MIGRANTS; SUBSTANCE-ABUSE; HIV PREVENTION; IMMIGRANT MEN; BEHAVIORS; WORKERS AB The purpose of this study was to examine patterns and predictors of HIV/STI risk over time among Latino migrant men in a new receiving community. Latino men (N = 125) were interviewed quarterly for 18 months and HIV/STI tested annually. Selected individual, environmental and cultural factors by partner type and condom use were explored longitudinally and in a cross-section. Sex with female sex workers (FSWs) and multiple partners decreased, sex with main partners and abstinence increased, while the number of casual partners remained stable. Consistent condom use was highest with FSWs, lowest with main partners and midrange with casual partners with no trends over time. STI morbidity was low; no HIV was detected. Drug use and high mobility were associated with inconsistent condom use with FSW, whereas having family in the household was protective. HIV/STI prevention efforts should focus on drug using Latino migrants who are highly mobile and should foster healthy social connections. C1 [Kissinger, Patricia; Kovacs, Stephanie; Anderson-Smits, Colin; Schmidt, Norine; Salinas, Oscar; Hembling, John; Beaulieu, Allyson] Tulane Univ, Dept Epidemiol SL 18, Sch Publ Hlth & Trop Med, New Orleans, LA 70112 USA. [Longfellow, Lisa] Louisiana Off Publ Hlth, Sexually Transmitted Dis Control Program, New Orleans, LA USA. [Liddon, Nicole] Ctr Dis Control & Prevent, Div Sexually Transmitted Dis, Atlanta, GA USA. [Rice, Janet] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Biostat, New Orleans, LA USA. [Shedlin, Michele] NYU, Coll Nursing, New York, NY USA. RP Kissinger, P (reprint author), Tulane Univ, Dept Epidemiol SL 18, Sch Publ Hlth & Trop Med, 1440 Canal St, New Orleans, LA 70112 USA. EM kissing@tulane.edu OI Shedlin, Michele/0000-0003-2112-7601 FU NCHHSTP CDC HHS [H25 PS604346-16]; NIDA NIH HHS [R21DA030269] NR 50 TC 12 Z9 12 U1 2 U2 12 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1090-7165 J9 AIDS BEHAV JI AIDS Behav. PD JAN PY 2012 VL 16 IS 1 BP 199 EP 213 DI 10.1007/s10461-011-9945-7 PG 15 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA 875SI UT WOS:000299054700024 PM 21484281 ER PT J AU Barrington, C Wejnert, C Guardado, ME Nieto, AI Bailey, GP AF Barrington, Clare Wejnert, Cyprian Guardado, Maria Elena Nieto, Ana Isabel Bailey, Gabriela Paz TI Social Network Characteristics and HIV Vulnerability Among Transgender Persons in San Salvador: Identifying Opportunities for HIV Prevention Strategies SO AIDS AND BEHAVIOR LA English DT Article DE El Salvador; Transgender; HIV; Men who have sex with men; Sexually transmitted infections; Respondent driven sampling ID DRIVEN SAMPLING METHODOLOGY; RISK BEHAVIORS; INTERNATIONAL SETTINGS; HIDDEN POPULATIONS; 3 CITIES; COMMUNITY; SEX; INTERVENTION; SURVEILLANCE; EDUCATION AB The purpose of this study is to improve understanding of HIV vulnerability and opportunities for HIV prevention within the social networks of male-to-female transgender persons in San Salvador, El Salvador. We compare HIV prevalence and behavioral data from a sample of gay-identified men who have sex with men (MSM) (n = 279), heterosexual or bisexual identified MSM (n = 229) and transgender persons (n = 67) recruited using Respondent Driven Sampling. Transgender persons consistently reported higher rates of HIV risk behavior than the rest of the study population and were significantly more likely to be involved in sex work. While transgender persons reported the highest rates of exposure to HIV educational activities they had the lowest levels of HIV-related knowledge. Transgender respondents' social networks were homophilous and efficient at recruiting other transgender persons. Findings suggest that transgender social networks could provide an effective and culturally relevant opportunity for HIV prevention efforts in this vulnerable population. C1 [Bailey, Gabriela Paz] Del Valle Univ, Ctr Hlth Studies, Guatemala City, Guatemala. [Barrington, Clare] Univ N Carolina, Dept Hlth Behav & Hlth Educ, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA. [Wejnert, Cyprian] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. [Guardado, Maria Elena; Bailey, Gabriela Paz] Tephinet Inc, Atlanta, GA USA. [Nieto, Ana Isabel] Minist Hlth, Natl AIDS Program, San Salvador, El Salvador. RP Bailey, GP (reprint author), Del Valle Univ, Ctr Hlth Studies, Guatemala City, Guatemala. EM cbarring@email.unc.edu; gmb5@cdc.gov FU NICHD NIH HHS [R24 HD050924]; NIMHD NIH HHS [L60 MD002984] NR 40 TC 15 Z9 15 U1 2 U2 6 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1090-7165 J9 AIDS BEHAV JI AIDS Behav. PD JAN PY 2012 VL 16 IS 1 BP 214 EP 224 DI 10.1007/s10461-011-9959-1 PG 11 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA 875SI UT WOS:000299054700025 PM 21538082 ER PT J AU Parker, DL Rybak, ME Pfeiffer, CM AF Parker, Daniel L. Rybak, Michael E. Pfeiffer, Christine M. TI Phytoestrogen biomonitoring: an extractionless LC-MS/MS method for measuring urinary isoflavones and lignans by use of atmospheric pressure photoionization (APPI) SO ANALYTICAL AND BIOANALYTICAL CHEMISTRY LA English DT Article DE Isoflavones; Lignans; Phytoestrogens; Urine; Atmospheric pressure photoionization; Electrospray; Mass spectrometry; ESI; APCI; APPI ID TANDEM MASS-SPECTROMETRY; DILUTION LIQUID-CHROMATOGRAPHY; CANCER RISK; HPLC-MS/MS; QUANTIFICATION; METAANALYSIS; METABOLITES; PLASMA; BIOAVAILABILITY; IONIZATION AB We present here a high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantifying phytoestrogenic isoflavones (daidzein, equol, genistein, and O-desmethylangolensin) and lignans (enterodiol and enterolactone) in urine without the use of extraction or the preconcentration techniques inherent in existing methods. The development of this concept was made possible by use of atmospheric pressure photoionization (APPI); an ionization technique that we found to improve analyte sensitivity relative to electrospray ionization and atmospheric pressure chemical ionization for this particular group of compounds. The analytical performance of this method was equal to or exceeded that of comparable methods. Between-run coefficients of variation (CVs) across three quality control (QC) pool levels analyzed in duplicate over 20 days were 3.1-5.8% CV; within-run CVs were 2.3-6.0%. Accuracy, as determined by average spike recovery in QC pools, was generally within +/- 10% of being quantitative (100%). Relative limits of detection were 0.04-0.4 ng/mL urine, with absolute detection limits as low as 0.1 pg. This method was applied to the analysis of > 2,500 urine specimens for the 2005-2006 Centers for Disease Control and Prevention's National Health and Nutrition Examination Survey (NHANES). The method was capable of quantifying these compounds in 95-100% of study samples. This work is the first ever report of using APPI for the LC-MS/MS determination of these compounds in urine. It is also the first method of its kind to do so without any need for analyte extraction or preconcentration prior to analysis. C1 [Parker, Daniel L.; Rybak, Michael E.; Pfeiffer, Christine M.] US Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. RP Rybak, ME (reprint author), US Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, 4770 Buford Hwy,MS F-55, Atlanta, GA 30341 USA. EM MRybak@cdc.gov RI Rybak, Michael/T-1026-2016 OI Rybak, Michael/0000-0003-1650-8581 NR 39 TC 11 Z9 11 U1 0 U2 20 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1618-2642 J9 ANAL BIOANAL CHEM JI Anal. Bioanal. Chem. PD JAN PY 2012 VL 402 IS 3 BP 1123 EP 1136 DI 10.1007/s00216-011-5550-x PG 14 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 870CE UT WOS:000298645900013 PM 22124753 ER PT J AU Ding, YS Chou, T Abdul-Salaam, S Hearn, B Watson, CH AF Ding, Yan S. Chou, Theodore Abdul-Salaam, Shadeed Hearn, Bryan Watson, Clifford H. TI Development of a Method to Estimate Mouth-Level Benzo[a]pyrene Intake by Filter Analysis SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Article ID CIGARETTE-SMOKE; EXPOSURE AB Background: Benzo[a] pyrene (BaP) is one of the most potent carcinogens generated in cigarette smoke. During smoking, cigarette filters trap a significant portion of mainstream smoke benzo[ a] pyrene. This trapped portion is proportional to what exits the end of the filter and is drawn into the mouth of smokers. Methods: We developed a new method to estimate mouth-level BaP intake using filter analysis. In this analysis, cigarettes are smoked by a smoking machine using a variety of conditions to yield a range of mainstream smoke deliveries, which approximate a range of human puffing characteristics. Mainstream smoke BaP collected on Cambridge filter pads and the corresponding 1-cm mouth-end cigarette filter butts is extracted, purified by solid-phase extraction, and quantified by high-performance liquid chromatography coupled with a fluorescence detector. On the basis of the amount of BaP retained in cigarette butts and the amount collected on pads, we can relate them using a linear regression model. Results: Using this model and subsequently analyzing cigarette filters collected from smokers, we are able to estimate their mouth-level intakes, which smokers received when they consumed cigarettes. We made a series of measurements using research cigarettes and select commercial cigarettes having a wide range of machine smoke "tar" and nicotine deliveries. Conclusions: In all cases, results indicate a linear relation of BaP between cigarette filter butts and Cambridge filter pads, with R(2) ranging from 0.93 to 0.98. Impact: This technique provides a noninvasive means to examine intake on a per cigarette basis to examine both exposure and behavioral aspects of smoking. Cancer Epidemiol Biomarkers Prev; 21(1); 39-44. (C) 2011 AACR. C1 [Ding, Yan S.; Chou, Theodore; Abdul-Salaam, Shadeed; Hearn, Bryan; Watson, Clifford H.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. RP Ding, YS (reprint author), Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, 4770 Buford Highway NE,Mailstop F-47, Atlanta, GA 30341 USA. EM yding@cdc.gov FU Intramural CDC HHS [CC999999] NR 12 TC 4 Z9 5 U1 1 U2 5 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1055-9965 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD JAN PY 2012 VL 21 IS 1 BP 39 EP 44 DI 10.1158/1055-9965.EPI-11-0800 PG 6 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 875RH UT WOS:000299051500003 PM 22028404 ER PT J AU Vernon, SW Abotchie, PN McQueen, A White, A Eberth, JM Coan, SP AF Vernon, Sally W. Abotchie, Peter N. McQueen, Amy White, Arica Eberth, Jan M. Coan, Sharon P. TI Is the Accuracy of Self-Reported Colorectal Cancer Screening Associated with Social Desirability? SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Article ID VALIDITY; MODE; INTERVENTION; POPULATION; BEHAVIORS; APPROVAL; SCALE AB Background: Self-reported cancer screening behaviors are often overreported and may lead to biased estimates of prevalence and of subgroup differences in screening. We examined whether the tendency to give socially desirable responses was associated with concordance between self-reported colorectal cancer (CRC) screening behaviors and medical records. Methods: Primary care patients (n = 857) age 50 to 74 years completed a mail, face-to-face, or telephone survey that assessed CRC screening and social desirability measured by a short version of the Marlowe-Crowne scale. We used medical records to verify self-reports of fecal occult blood testing (FOBT), sigmoidoscopy, colonoscopy, and barium enema. Results: Social desirability scores were lower for whites versus African Americans, college graduates, and patients reporting no prior screening tests; they were higher for telephone versus mail or face-to-face survey respondents. In univariable logistic regression analysis, social desirability scores were not associated with concordance for FOBT (OR = 1.03, 95% CI = 0.94-1.13), sigmoidoscopy (OR = 0.95, 95% CI = 0.86-1.04), or colonoscopy (OR = 0.99, 95% CI = 0.88-1.11); however, lower social desirability scores were associated with increased concordance for barium enema (OR = 0.87, 95% CI = 0.77-0.99). In multivariable analyses, no associations were statistically significant. Conclusion: Social desirability as measured by the Marlowe-Crowne scale was not associated with accuracy of self-reported CRC tests in our sample, suggesting that other explanations for overreporting need to be explored. Impact: By understanding sources of response bias, we can improve the accuracy of self-report measures. Cancer Epidemiol Biomarkers Prev; 21(1); 61-65. (C) 2011 AACR. C1 [Vernon, Sally W.; Abotchie, Peter N.; Coan, Sharon P.] Univ Texas Hlth Sci Ctr, Sch Publ Hlth, Div Hlth Promot & Behav Sci, San Antonio, TX USA. [Eberth, Jan M.] Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA. [McQueen, Amy] Washington Univ, Sch Med, Div Hlth Behav Res, St Louis, MO USA. [White, Arica] Ctr Dis Control & Prevent, Epidemiol & Appl Res Branch, Div Canc Prevent & Control, Atlanta, GA USA. RP Vernon, SW (reprint author), Univ Texas Houston, Sch Publ Hlth, Div Hlth Promot & Behav Sci, 7000 Fannin St,Suite 2560, Houston, TX 77030 USA. EM sally.w.vernon@uth.tmc.edu RI Eberth, Jan/A-1335-2014 OI Eberth, Jan/0000-0001-9500-4212 FU Centers for Disease Control and Prevention [PRC SIP 19-04 U48 DP000057]; University of Texas School of Public Health Cancer Education; National Cancer Institute [R25CA57712]; American Cancer Society [08-222-01-CPPB] FX The authors thank Anthony Greisinger and the Kelsey-Seybold Clinic staff for supporting this project.; The project was funded by PRC SIP 19-04 U48 DP000057 from the Centers for Disease Control and Prevention (S.W. Vernon). P. N. Abotchie, A. White, and J.M. Eberth were supported by a pre/post-doctoral fellowship from the University of Texas School of Public Health Cancer Education and Career Development Program; National Cancer Institute Grant R25CA57712. A. McQueen is supported by an American Cancer Society Mentored Research Scholar Grant (08-222-01-CPPB). NR 20 TC 5 Z9 5 U1 0 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1055-9965 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD JAN PY 2012 VL 21 IS 1 BP 61 EP 65 DI 10.1158/1055-9965.EPI-11-0552 PG 5 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 875RH UT WOS:000299051500006 PM 22144501 ER PT J AU Gargano, JW Nisenbaum, R Lee, DR Ruffin, MT Steinau, M Horowitz, IR Flowers, LC Tadros, TS Birdsong, G Unger, ER AF Gargano, Julia W. Nisenbaum, Rosane Lee, Daisy R. Ruffin, Mack T. Steinau, Martin Horowitz, Ira R. Flowers, Lisa C. Tadros, Talaat S. Birdsong, George Unger, Elizabeth R. TI Age-Group Differences in Human Papillomavirus Types and Cofactors for Cervical Intraepithelial Neoplasia 3 among Women Referred to Colposcopy SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Article ID COLLABORATIVE REANALYSIS; INDIVIDUAL DATA; YOUNG-WOMEN; CANCER; RISK; PERSISTENCE; METAANALYSIS; PREVALENCE; INFECTION; CARCINOMA AB Background: Recommendations for high-risk human papillomavirus (HR-HPV) testing as an adjunct to cytology for cervical cancer screening differ by age group, because HR-HPV tests lack adequate specificity in women aged <30. Here, we assess age-group differences in HPV types and other risk factors for cervical intraepithelial neoplasia (CIN) grade 3 or worse (CIN3+) versus CIN0-2 in women from four colposcopy clinics. Methods: Women ages 18 to 69 (n = 1,658) were enrolled and completed structured interviews to elicit data on behavioral risk factors prior to their examinations. HPV genotyping was done on exfoliated cervical cell samples. We estimated relative risks (RR) for HPV types and cofactors for CIN3+, overall and stratified by age group. Results: After 2 years of follow-up, we identified 178 CIN3+, 1,305 CIN0-2, and 175 indeterminate outcomes. Nonvaccine HR-HPV types were only associated with CIN3+ among women >= 30 (RR = 2.3, 95% CI: 1.5-3.4; <30: RR = 0.9). Among all HR-HPV-positive women, adjusting for age, significant cofactors for CIN3+ included current smoking (RR = 1.5), former smoking (RR = 1.8), regular Pap screening (RR = 0.7), current regular condom use (RR = 0.5), and parity >= 5 (RR = 1.6, P(trend) for increasing parity = 0.07). However, the parity association differed by age group (>= 30: RR = 1.8, P(trend) 0.008; <30: RR = 0.9; P(trend) = .55). Conclusion: Subgroup variation by age in the risk of CIN3+ points to the importance of the timing of exposures in relation to CIN3+ detection. Impact: Future screening strategies need to consider natural history and secular trends in cofactor prevalence in the pursuit of appropriately sensitive and specific screening tools applied to appropriate age groups. Cancer Epidemiol Biomarkers Prev; 21(1); 111-21. (C) 2011 AACR. C1 [Gargano, Julia W.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Gargano, Julia W.; Lee, Daisy R.; Steinau, Martin; Unger, Elizabeth R.] Ctr Dis Control & Prevent, Chron Viral Dis Branch, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Nisenbaum, Rosane] St Michaels Hosp, Ctr Res Inner City Hlth, Keenan Res Ctr, Li Ka Shing Knowledge Inst, Toronto, ON M5B 1W8, Canada. [Nisenbaum, Rosane] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada. [Ruffin, Mack T.] Univ Michigan, Dept Family Med, Ann Arbor, MI 48109 USA. [Horowitz, Ira R.; Flowers, Lisa C.] Emory Univ, Sch Med, Dept Gynecol & Obstet, Atlanta, GA USA. [Horowitz, Ira R.; Flowers, Lisa C.] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA. [Tadros, Talaat S.; Birdsong, George] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA. [Tadros, Talaat S.; Birdsong, George] Grady Hlth Syst, Atlanta, GA USA. RP Gargano, JW (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv, MS C09,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM jgargano@cdc.gov OI Ruffin, Mack/0000-0001-8336-478X; Unger, Elizabeth/0000-0002-2925-5635 FU Ontario Ministry of Health and Long-Term Care; National Cancer Institute's Early Detection Research Network (EDRN) [Y1-CN-0101-01, Y1-CN-5005-01] FX We thank Drs. Jin-Mann Lin, Roumiana Boneva, and Mona Saraiya for their comments and suggestions on this work. R. Nisenbaum gratefully acknowledges the support of the Ontario Ministry of Health and Long-Term Care.; This work was supported in part by the National Cancer Institute's Early Detection Research Network (EDRN), Interagency Agreements Y1-CN-0101-01 and Y1-CN-5005-01. NR 37 TC 8 Z9 8 U1 0 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1055-9965 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD JAN PY 2012 VL 21 IS 1 BP 111 EP 121 DI 10.1158/1055-9965.EPI-11-0664 PG 11 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 875RH UT WOS:000299051500012 PM 22028398 ER PT J AU Ke, BX Ran, L Wu, SY Deng, XL Ke, CW Feng, ZJ Ma, L Varma, JK AF Ke, Bixia Ran, Lu Wu, Shuyu Deng, Xiaoling Ke, Changwen Feng, Zijian Ma, Li Varma, Jay K. TI Survey of Physician Diagnostic and Treatment Practices for Patients with Acute Diarrhea in Guangdong Province, China SO FOODBORNE PATHOGENS AND DISEASE LA English DT Article ID ACUTE INFECTIOUS DIARRHEA; UNITED-STATES; FOODBORNE DISEASE; HEALTH SYSTEM; GUIDELINES; BURDEN AB Although international clinical guidelines generally recommend performing bacterial stool culture in patients with acute diarrhea and fever and discourage routine antibiotic prescribing, clinical practice varies. Understanding practice patterns can help health officials assess the sensitivity of laboratory-based enteric infection surveillance systems and the need to improve antibiotic prescribing practices. We surveyed physicians in Guangdong province, China, to measure their practices for patients with acute diarrhea. A standardized questionnaire was used to interview physicians working in hospitals participating in a Salmonella surveillance system in Guangdong, China. The questionnaire asked physicians about their routine practice for patients with diarrhea, including how they managed the last patient they had seen with acute diarrhea. We calculated the odds ratio and 95% confidence interval for factors associated with ordering a stool culture and for prescribing antibiotics. We received surveys from 237 physicians across 22 hospitals in Guangdong. For the last patient with diarrhea whom they had evaluated, 134 (57%) reported ordering a stool culture. The most common reasons for not ordering a stool culture included that it takes too long to receive the result, that the patient is not willing to pay for the test, and that the patient's illness was too mild to warrant testing. Most physicians prescribed at least one medication for the last patient with diarrhea whom they had evaluated. Of the 237 physicians surveyed, 153 (65%) prescribed antibiotics, 135 (57%) probiotics, and 115 (49%), a gastric mucosal protective drug. In conclusion, physicians in Guangdong, China, reported high rates of ordering bacterial stool cultures from patients with diarrhea, possibly associated with their hospital's participation in a special surveillance project. The high rate of antibiotic prescribing suggests that efforts to promote judicious antibiotic use, such as physician education, are needed. C1 [Ke, Bixia; Deng, Xiaoling; Ke, Changwen] Guangdong Prov Ctr Dis Control & Prevent, Guangzhou 510300, Guangdong, Peoples R China. [Ran, Lu; Feng, Zijian; Ma, Li] Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China. [Wu, Shuyu; Varma, Jay K.] US Ctr Dis Control & Prevent, Atlanta, GA USA. RP Ke, CW (reprint author), Guangdong Prov Ctr Dis Control & Prevent, 176 Xin Gang W Rd, Guangzhou 510300, Guangdong, Peoples R China. EM kecw1965@yahoo.com.cn FU China-U.S. Collaborative Program on Emerging and Re-Emerging Infectious Diseases; Medical Scientific Research Foundation in Guangdong [C2006003]; WHO Global Foodborne Infections Network FX This project was supported by the China-U.S. Collaborative Program on Emerging and Re-Emerging Infectious Diseases and the Medical Scientific Research Foundation in Guangdong (C2006003). The authors also acknowledge the support from WHO Global Foodborne Infections Network. NR 17 TC 6 Z9 10 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1535-3141 J9 FOODBORNE PATHOG DIS JI Foodborne Pathog. Dis. PD JAN PY 2012 VL 9 IS 1 BP 47 EP 53 DI 10.1089/fpd.2011.0964 PG 7 WC Food Science & Technology SC Food Science & Technology GA 875LL UT WOS:000299031300008 PM 21988400 ER PT J AU Shefer, A Strikas, R Bridges, CB AF Shefer, Abigail Strikas, Raymond Bridges, Carolyn B. TI Updated Recommendations of the Advisory Committee on Immunization Practices for Healthcare Personnel Vaccination: A Necessary Foundation for the Essential Work That Remains to Build Successful Programs SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Editorial Material ID MANDATORY INFLUENZA VACCINATION; UNITED-STATES; REQUIREMENTS; HOSPITALS; RATES C1 [Shefer, Abigail; Strikas, Raymond; Bridges, Carolyn B.] Ctr Dis Control & Prevent, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Shefer, A (reprint author), NCIRD CDC, 1600 Clifton Rd NE,Mailstop A-19, Atlanta, GA 30333 USA. EM ams7@cdc.gov NR 37 TC 4 Z9 4 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD JAN PY 2012 VL 33 IS 1 BP 71 EP 74 DI 10.1086/662715 PG 4 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 876CP UT WOS:000299085100012 PM 22173525 ER PT J AU Paulozzi, LJ Kilbourne, EM Shah, NG Nolte, KB Desai, HA Landen, MG Harvey, W Loring, LD AF Paulozzi, Leonard J. Kilbourne, Edwin M. Shah, Nina G. Nolte, Kurt B. Desai, Hema A. Landen, Michael G. Harvey, William Loring, Larry D. TI A History of Being Prescribed Controlled Substances and Risk of Drug Overdose Death SO PAIN MEDICINE LA English DT Article DE Opioid; Analgesic; Prescriptions; Abuse; Safety; Pain Management ID EMERGENCY-DEPARTMENT VISITS; PRESCRIPTION OPIOIDS; UNITED-STATES; CHRONIC PAIN; NEW-MEXICO; PATTERNS; ABUSE; ASSOCIATION; ANALGESICS; HEROIN AB Objective. The abuse of prescription drugs has increased dramatically since 1990. Persons who overdose on such drugs frequently consume large doses and visit multiple providers. The risk of fatal overdose for different patterns of use of opioid analgesics and sedative/hypnotics has not been fully quantified. Design. Matched case-control study. Cases were 300 persons who died of unintentional drug overdoses in New Mexico during 2006-2008, and controls were 5,993 patients identified through the state prescription monitoring program with matching 6-month exposure periods. Outcome Measures. Death from drug overdose or death from opioid overdose. Exposures were demographic variables and characteristics of prescription history. Crude and adjusted odds ratios (AOR) were calculated. Results. Increased risk was associated with male sex (AOR 2.4, 95% confidence interval [CI] 1.8-3.1), one or more sedative/ hypnotic prescriptions (AOR 3.0, CI 2.2-4.2), greater age (AOR 1.3, CI 1.2-1.4 for each 10-year increment), number of prescriptions (AOR 1.1, CI 1.1-1.1 for each additional prescription), and a prescription for buprenorphine (AOR 9.5, CI 3.0-30.0), fentanyl (AOR 3.5, CI 1.7-7.0), hydromorphone (AOR 3.3, CI 1.4-7.5), methadone (AOR 4.9, CI 2.5-9.6), or oxycodone (AOR 1.9, CI 1.4-2.6). Patients receiving a daily average of >40 morphine milligram equivalents had an OR of 12.2 (CI 9.2-16.0). Conclusions. Patients being prescribed opioid analgesics frequently or at high dosage face a substantial overdose risk. Prescription monitoring programs might be the best way for prescribers to know their patients' prescription histories and accurately assess overdose risk. C1 [Paulozzi, Leonard J.] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Div Unintent Injury Prevent, El Paso, TX 79912 USA. [Kilbourne, Edwin M.] Martin Blanck & Associates, Falls Church, VA USA. [Shah, Nina G.; Landen, Michael G.] New Mexico Dept Hlth, Santa Fe, NM USA. [Nolte, Kurt B.] Univ New Mexico, Sch Med, Off Med Investigator, Albuquerque, NM 87131 USA. [Desai, Hema A.] Booz Allen Hamilton Inc, Atlanta, GA USA. [Harvey, William; Loring, Larry D.] New Mexico Prescript Monitoring Program, Albuquerque, NM USA. RP Paulozzi, LJ (reprint author), Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Div Unintent Injury Prevent, 601 Sunland Pk Dr,Suite 200, El Paso, TX 79912 USA. EM lbp4@cdc.gov FU Centers for Disease Control and Prevention; New Mexico Department of Health FX Authors have no financial interests in this manuscript. All funding for this study came from the Centers for Disease Control and Prevention and the New Mexico Department of Health. NR 45 TC 91 Z9 91 U1 3 U2 10 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1526-2375 J9 PAIN MED JI Pain Med. PD JAN PY 2012 VL 13 IS 1 BP 87 EP 95 DI 10.1111/j.1526-4637.2011.01260.x PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 874KB UT WOS:000298954200008 PM 22026451 ER PT J AU Gregory, CJ Tomashek, KM AF Gregory, Christopher J. Tomashek, Kay M. TI Management of severe dengue SO PEDIATRIC CRITICAL CARE MEDICINE LA English DT Letter C1 [Gregory, Christopher J.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. Ctr Dis Control & Prevent, San Juan, PR USA. RP Gregory, CJ (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. NR 5 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1529-7535 J9 PEDIATR CRIT CARE ME JI Pediatr. Crit. Care Med. PD JAN PY 2012 VL 13 IS 1 BP 125 EP 125 DI 10.1097/PCC.0b013e318219181b PG 1 WC Critical Care Medicine; Pediatrics SC General & Internal Medicine; Pediatrics GA 875YT UT WOS:000299073000049 PM 22222665 ER PT J AU Stockman, LJ Curns, AT Anderson, LJ Fischer-Langley, G AF Stockman, Lauren J. Curns, Aaron T. Anderson, Larry J. Fischer-Langley, Gayle TI Respiratory Syncytial Virus-associated Hospitalizations Among Infants and Young Children in the United States, 1997-2006 SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE bronchiolitis; lower respiratory tract illness; burden ID POPULATION-BASED SURVEILLANCE; RISK-FACTORS; US CHILDREN; INFECTION; BRONCHIOLITIS; INFLUENZA; BURDEN; ALASKA; ADULTS; RATES AB Background: Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract disease among young children in the United States. RSV-associated hospitalization increased among children in the United States during 1980 through 1996. In this study, we updated national estimates of RSV hospitalization rates among US children through 2006. Methods: We conducted a retrospective analysis of hospital discharges for lower respiratory tract illness (LRTI) in children <5 years old from the National Hospital Discharge Survey. LRTI hospitalizations were identified by using International Classification of Diseases, Ninth Revision, Clinical Modification codes. RSV-coded hospitalizations were International Classification of Diseases, Ninth Revision, Clinical Modification codes 466.11, 480.1, and 079.6. RSV-associated hospitalizations were the sum of RSV-coded hospitalizations and a proportion of hospitalizations coded as bronchiolitis and pneumonia during the RSV season. Results: RSV-coded hospitalizations accounted for 24% of an estimated 5.5 million LRTI hospitalizations among children <5 years of age during the 10 study years, 1997-2006. The RSV-coded hospitalization rate in infants <1 year old was 26.0 per 1000, with no significant difference between study years. The hospitalization rate was highest among infants <3 months old (48.9 per 1000), followed by infants 3 to 5 months old (28.4 per 1000), and lower among those <1 year old (1.8 per 1000). An estimated 132,000 to 172,000 RSV-associated hospitalizations occurred annually in children <5 years of age. Conclusion: RSV hospitalization rates remained steady during 1997 to 2006 and were a substantial burden in the United States, especially among infants and young children. A safe and effective RSV vaccine is needed. C1 [Stockman, Lauren J.; Curns, Aaron T.; Anderson, Larry J.; Fischer-Langley, Gayle] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA. RP Stockman, LJ (reprint author), Ctr Dis Control & Prevent, Div Viral Dis, 1600 Clifton Rd,Mailstop A-34, Atlanta, GA 30333 USA. EM LStockman@cdc.gov NR 31 TC 104 Z9 106 U1 2 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD JAN PY 2012 VL 31 IS 1 BP 5 EP 9 DI 10.1097/INF.0b013e31822e68e6 PG 5 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA 875QV UT WOS:000299050100007 PM 21817948 ER PT J AU Grosse, SD AF Grosse, Scott D. TI Incidence-based cost estimates require population-based incidence data. A critique of Mahan et al. SO THROMBOSIS AND HAEMOSTASIS LA English DT Letter ID DEEP-VEIN THROMBOSIS; VENOUS THROMBOEMBOLISM; PULMONARY-EMBOLISM; UNITED-STATES; RISK-FACTORS; SURVEILLANCE; PROPHYLAXIS; PREVENTION; MORTALITY; PATIENT C1 [Grosse, Scott D.] Ctr Dis Control & Prevent, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. RP Grosse, SD (reprint author), 1600 Clifton Rd NE,Mail Stop E-64, Atlanta, GA 30333 USA. EM sgrosse@cdc.gov NR 33 TC 7 Z9 7 U1 0 U2 0 PU SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN PI STUTTGART PA HOLDERLINSTRASSE 3, D-70174 STUTTGART, GERMANY SN 0340-6245 J9 THROMB HAEMOSTASIS JI Thromb. Haemost. PD JAN PY 2012 VL 107 IS 1 BP 192 EP 193 DI 10.1160/TH11-09-0666 PG 2 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA 879UO UT WOS:000299357900027 PM 22159589 ER PT J AU England, LJ Kim, SY Shapiro-Mendoza, CK Wilson, HG Kendrick, JS Satten, GA Lewis, CA Whittern, P Tucker, MJ Callaghan, WM AF England, Lucinda J. Kim, Shin Y. Shapiro-Mendoza, Carrie K. Wilson, Hoyt G. Kendrick, Juliette S. Satten, Glen A. Lewis, Claire A. Whittern, Persenia Tucker, Myra J. Callaghan, William M. TI Maternal smokeless tobacco use in Alaska Native women and singleton infant birth size SO ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA LA English DT Article DE birth size; birthweight; cigarettes; pregnancy; small for gestational age; smokeless tobacco ID CIGARETTE-SMOKING; OUTCOMES; SNUFF AB Objective. To examine the effects of maternal prenatal smokeless tobacco use on infant birth size. Design. A retrospective medical record review of 502 randomly selected deliveries. Population and Setting. Singleton deliveries to Alaska Native women residing in a defined geographical region in western Alaska, 19972005. Methods. A regional medical center's electronic records were used to identify singleton deliveries. Data on maternal tobacco exposure and pregnancy outcomes were abstracted from medical records. Logistic models were used to estimate adjusted mean birthweight, length and head circumference for deliveries to women who used no tobacco (n=121), used smokeless tobacco (n=237) or smoked cigarettes (n=59). Differences in mean birthweight, length and head circumference, 95% confidence intervals and p-values were calculated using non-users as the reference group. Main Outcome Measures. Infant birthweight, crownheel length and head circumference. Results. After adjustment for gestational age and other potential confounders, the mean birthweight of infants of smokeless tobacco users was reduced by 78g compared with that of infants of non-users (p=0.18) and by 331g in infants of smokers (p<0.01). No association was found between maternal smokeless tobacco use and infant length or infant head circumference. Conclusions. We found a modest but non-significant reduction in the birthweight of infants of smokeless tobacco users compared with infants of tobacco non-users. Because smokeless tobacco contains many toxic compounds that could affect other pregnancy outcomes, results of this study should not be construed to mean that smokeless tobacco use is safe during pregnancy. C1 [England, Lucinda J.; Kim, Shin Y.; Shapiro-Mendoza, Carrie K.; Wilson, Hoyt G.; Kendrick, Juliette S.; Satten, Glen A.; Tucker, Myra J.; Callaghan, William M.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30030 USA. [Lewis, Claire A.; Whittern, Persenia] Yukon Kuskokwim Hlth Corp, Bethel, AK USA. RP England, LJ (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, 4770 Buford Highway NE MS K 23, Atlanta, GA 30030 USA. EM lbe9@cdc.gov OI Satten, Glen/0000-0001-7275-5371 FU Centers for Disease Control and Prevention through Indian Health Service [98FED05900] FX This study was supported by the Centers for Disease Control and Prevention through Indian Health Service Interagency Agreement 98FED05900. NR 12 TC 17 Z9 17 U1 1 U2 7 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0001-6349 J9 ACTA OBSTET GYN SCAN JI Acta Obstet. Gynecol. Scand. PD JAN PY 2012 VL 91 IS 1 BP 93 EP 103 DI 10.1111/j.1600-0412.2011.01273.x PG 11 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 860BU UT WOS:000297922200016 PM 21902677 ER PT J AU Kew, OM Nathanson, N AF Kew, Olen M. Nathanson, Neal TI RE: "FROM EMERGENCE TO ERADICATION: THE EPIDEMIOLOGY OF POLIOMYELITIS DECONSTRUCTED" REPLY SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Letter ID VACCINE-DERIVED POLIOVIRUS C1 [Kew, Olen M.] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Nathanson, Neal] Univ Penn, Sch Med, Global Hlth Programs Off, Philadelphia, PA 19104 USA. RP Kew, OM (reprint author), Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM omk1@cdc.gov NR 14 TC 0 Z9 0 U1 2 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JAN 1 PY 2012 VL 175 IS 1 BP 86 EP 87 DI 10.1093/aje/kwr427 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 866MF UT WOS:000298384300013 ER PT J AU Klebanoff, MA Branum, AM Schoendorf, KC Lynch, CD AF Klebanoff, Mark A. Branum, Amy M. Schoendorf, Kenneth C. Lynch, Courtney D. TI Electronic fetal heart rate monitoring and its relationship to neonatal and infant mortality in the United States SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Letter ID VITAL-STATISTICS C1 [Klebanoff, Mark A.] Ohio State Univ, Coll Med, Dept Pediat, Ohio Perinatal Res Network, Columbus, OH 43205 USA. [Klebanoff, Mark A.] Nationwide Childrens Hosp, Columbus, OH 43205 USA. [Branum, Amy M.; Schoendorf, Kenneth C.] Ctr Dis Control & Prevent, Infant Child & Womens Hlth Stat Branch, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Lynch, Courtney D.] Ohio State Univ, Coll Med, Dept Obstet & Gynecol, Columbus, OH 43210 USA. RP Klebanoff, MA (reprint author), Ohio State Univ, Coll Med, Dept Pediat, Ohio Perinatal Res Network, Columbus, OH 43205 USA. EM mark.klebanoff@nationwidechildrens.org NR 4 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2012 VL 206 IS 1 BP E18 EP E19 DI 10.1016/j.ajog.2011.08.008 PG 3 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 866GT UT WOS:000298369200006 PM 21963309 ER PT J AU Lampe, MA Smith, DK Nesheim, SR AF Lampe, Margaret A. Smith, Dawn K. Nesheim, Steven R. TI Safer conception options for HIV-serodiscordant couples REPLY SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Letter C1 [Lampe, Margaret A.; Smith, Dawn K.; Nesheim, Steven R.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV STD & TB Prevent, Atlanta, GA 30333 USA. RP Lampe, MA (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV STD & TB Prevent, 1600 Clifton Rd,MS E-45, Atlanta, GA 30333 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2012 VL 206 IS 1 BP E21 EP E22 DI 10.1016/j.ajog.2011.08.015 PG 3 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 866GT UT WOS:000298369200011 ER PT J AU Bateman, BT Mhyre, JM Callaghan, WM Kuklina, EV AF Bateman, Brian T. Mhyre, Jill M. Callaghan, William M. Kuklina, Elena V. TI Peripartum hysterectomy in the United States: nationwide 14 year experience SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article; Proceedings Paper CT 43rd Annual Meeting of the Society-for-Obstetric-Anesthesia-and-Perinatology CY APR 13-17, 2011 CL Henderson, NV SP Soc Obstet Anesthesia & Perinatol DE epidemiology; hysterectomy; postpartum hemorrhage; uterine atony ID POSTPARTUM HEMORRHAGE; CESAREAN DELIVERIES; MATERNAL MORBIDITY; TRENDS; RISK; EPIDEMIOLOGY; MORTALITY; OUTCOMES; BIRTH AB OBJECTIVE: The objective of the study was to examine the trends in the rate of peripartum hysterectomy and the contribution of changes in maternal characteristics to these trends. STUDY DESIGN: This was a cross-sectional study of peripartum hysterectomy identified from hospitalizations for delivery recorded in the 1994-2007 Nationwide Inpatient Sample. RESULTS: The overall rate of peripartum hysterectomy increased by 15% during the study period. The rate of hysterectomy for abnormal placentation increased by 1.2-fold; adjustment for previous cesarean delivery explained nearly all of this increase. The rate of hysterectomy for uterine atony following repeat cesarean delivery increased nearly 4-fold, following primary cesarean delivery approximately 2.5-fold, and following vaginal delivery about 1.5-fold. This fast growing trend in peripartum hysterectomy secondary to uterine atony was also largely explained by increasing rates of primary and repeat cesareans. CONCLUSION: Rates of peripartum hysterectomy increased substantially in the United States from 1994 to 2007; much of this increase was due to rising rates of cesarean delivery. C1 [Bateman, Brian T.] Harvard Univ, Sch Med, Dept Anesthesia Crit Care & Pain Med, Div Obstet Anesthesia, Boston, MA 02114 USA. [Mhyre, Jill M.] Univ Michigan Hlth Syst, Dept Anesthesiol, Ann Arbor, MI USA. [Callaghan, William M.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Kuklina, Elena V.] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Bateman, BT (reprint author), Harvard Univ, Sch Med, Dept Anesthesia Crit Care & Pain Med, Div Obstet Anesthesia, 55 Fruit St, Boston, MA 02114 USA. EM bbateman@partners.org NR 39 TC 4 Z9 7 U1 0 U2 4 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2012 VL 206 IS 1 AR 63.e1 DI 10.1016/j.ajog.2011.07.030 PG 8 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 866GT UT WOS:000298369200028 PM 21982025 ER PT J AU Sheffer, MA Baker, TB Fraser, DL Adsit, RT McAfee, TA Fiore, MC AF Sheffer, Megan A. Baker, Timothy B. Fraser, David L. Adsit, Robert T. McAfee, Timothy A. Fiore, Michael C. TI Fax Referrals, Academic Detailing, and Tobacco Quitline Use A Randomized Trial SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID SMOKING-CESSATION; SMOKERS QUITLINE; PATIENT SATISFACTION; PROVIDER ADHERENCE; TEACHABLE MOMENT; HEALTH CENTERS; CLINICAL-TRIAL; PRIMARY-CARE; PHYSICIAN; SUPPORT AB Background: Fax referral programs quickly and economically can link smokers' visiting primary care clinics to state-based telephone quitlines. Yet, it is unclear how to optimize use of this strategy. Purpose: To evaluate the potential of enhanced academic detailing in clinics (i.e., on-site training, technical assistance, and performance feedback) to boost utilization of a fax referral program called Fax to Quit. Design: Participants were randomized to one of two intervention conditions. Setting/participants: Participants were drawn from 49 primary care clinics in southeastern Wisconsin. The sample size was based on a power analysis in which the control intervention condition was estimated to generate 0.5 referrals/clinic/month and the experimental condition 2.0 referrals/clinic/month. Interventions: One of two fax referral program interventions was administered: the control condition Fax to Quit-Only (F2Q-Only) or the experimental condition Fax to Quit plus Enhanced Academic Detailing (F2Q+EAD). Main outcome measures: Clinic- and clinician-specific referral and quality referral rates (those resulting in quitline enrollment) were measured for 13 months post-intervention, starting in March 2009. Results: Mean number of post-intervention referrals/clinician to the Wisconsin Tobacco Quitline was 5.6 times greater for F2Q+EAD (8.5, SD=7.0) compared to F2Q-Only (1.6, SD=3.6, p<0.001). The F2Q+EAD (4.8, SD=4.1) condition produced a greater mean number of quality referrals/clinician than did the F2Q-Only (0.86, SD=1.8, p<0.001) condition. Data were analyzed in 2010. Conclusions: Enhanced academic detailing, which included on-site training, technical assistance, and performance feedback, increased the number of referrals more than fivefold over a fax referral program implemented without such enhanced academic detailing. C1 [Sheffer, Megan A.; Baker, Timothy B.; Fraser, David L.; Adsit, Robert T.; Fiore, Michael C.] Univ Wisconsin, Sch Med & Publ Hlth, Ctr Tobacco Res & Intervent, Madison, WI USA. [McAfee, Timothy A.] CDC, Off Smoking & Hlth, Atlanta, GA 30333 USA. RP Sheffer, MA (reprint author), Aurora Hlth Care, Patient Ctr Outcomes Res Div Clin Res, 1020 N12th St,ASMC Suite 401, Milwaukee, WI 53233 USA. EM megan.sheffer@aurora.org FU CDC [5R18DP001146]; Pfizer; GlaxoSmithKline; Nabi FX This work was carried out by the University of Wisconsin-Madison, Center for Tobacco Research and Intervention, Madison WI with funding from CDC grant 5R18DP001146.; TAM was employed by and owned stock in Free & Clear, an organization providing quitline services in Wisconsin. He was also an unpaid member of the Board of Directors of the nonprofit North American Quitline Consortium. Over the past 5 years, MCF has served as an investigator on research studies at the University of Wisconsin that were funded wholly or in part by Pfizer, GlaxoSmithKline, and Nabi. From 1997 to 2010, MCF held a University of Wisconsin named Chair for the Study of Tobacco Dependence, made possible by a gift to the university from GlaxoWellcome. No other authors reported financial disclosures. NR 74 TC 21 Z9 21 U1 3 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2012 VL 42 IS 1 BP 21 EP 28 DI 10.1016/j.amepre.2011.08.028 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 865EP UT WOS:000298294000006 PM 22176842 ER PT J AU Regan, AK Dube, SR Arrazola, R AF Regan, Annette K. Dube, Shanta R. Arrazola, Rene TI Smokeless and Flavored Tobacco Products in the U.S. 2009 Styles Survey Results SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID YOUNG-ADULTS; SMOKING; ADOLESCENT; CIGARETTES; PROMOTIONS; SMOKERS; STATES; USERS; SNUS; BAR AB Background: A number of noncigarette tobacco products, including some novel products, recently have been marketed by the tobacco industry, which raises concerns from tobacco control authorities. Purpose: This study aimed to assess current popularity of several noncigarette tobacco products in the U.S. Methods: In 2009, a total of 10,587 adults completed a consumer mail-in survey (ConsumerStyles). Based on survey results, the weighted percentages of adults who heard and tried snus, dissolvable tobacco products, flavored little cigars, and flavored cigarettes were computed in 2010. A subset of this sample (n=4556) completed the HealthStyles survey, which included items about health perceptions of these products and use in the past 30 days. Results: The percentage of U. S. adults in the sample who were aware of these products ranged from 10.4% (dissolvable tobacco) to 44.6% (flavored little cigars). One third of adults who had heard of flavored little cigars tried them and 10.1% had used them in the past 30 days; among those who had heard of them, 27.4% tried flavored cigarettes and 12.6% tried snus. In general, young adults, men, and smokers were most likely to have heard of each product. At least one third of adults were uncertain if these products were as harmful as cigarettes (range=37.3% [snus] to 50.3% [dissolvable tobacco]). Conclusions: The awareness of these tobacco products in this sample varied. Groups with a higher prevalence of smoking and tobacco use (e. g., men, people with low levels of education) may be a target audience for marketing and promotions. As availability of products change, continued surveillance is warranted in the U. S. (Am J Prev Med 2012;42(1):29-36) Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine C1 [Regan, Annette K.; Dube, Shanta R.; Arrazola, Rene] CDC, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Dube, SR (reprint author), CDC, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway,MS-K50, Atlanta, GA 30341 USA. EM sdube@cdc.gov OI Regan, Annette/0000-0002-3879-6193 NR 35 TC 29 Z9 29 U1 0 U2 19 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2012 VL 42 IS 1 BP 29 EP 36 DI 10.1016/j.amepre.2011.08.019 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 865EP UT WOS:000298294000007 PM 22176843 ER PT J AU Liddon, NC Leichliter, JS Markowitz, LE AF Liddon, Nicole C. Leichliter, Jami S. Markowitz, Lauri E. TI Human Papillomavirus Vaccine and Sexual Behavior Among Adolescent and Young Women SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID AGED 13-17 YEARS; CERVICAL-CANCER WORLDWIDE; UNITED-STATES; COVERAGE AB Background: Vaccines to prevent certain types of human papillomavirus (HPV) and associated cancers are recommended for routine use among young women. Nationally representative reports of vaccine uptake have not explored the relationship between HPV vaccine initiation and various sexual behaviors. Purpose: Explore sexual behavior and demographic correlates of HPV vaccine initiation from a nationally representative survey of adolescent and young adult women. Methods: In 2007-2008, a total of 1243 girls/women aged 15-24 years responded to questions about receiving HPV vaccine in the National Survey of Family Growth (NSFG). In 2010, demographic and sexual behavior correlates were evaluated in bivariate and multivariate analyses by age. Results: HPV vaccine initiation was higher among those aged 15-19 years than those aged 20-24 years (30.3% vs 15.9%, p<0.001). No differences existed by race/ethnicity for those aged 15-19 years, but among women aged 20-24 years, non-Hispanic blacks were less likely than non-Hispanic whites to have received the HPV vaccine (AOR=0.15). HPV vaccine initiation was greater for those with insurance regardless of age. HPV vaccination was not associated with being sexually active or number of sex partners at either age. Among sexually active adolescents aged 15-19 years, those who received HPV vaccine were more likely to always wear a condom (AOR=3.0). Conclusions: This study highlights disparities in HPV vaccine initiation by insurance status among girls/women aged 15-24 years and by race/ethnicity among women aged >19 years. No association was found between HPV vaccination and risky sexual behavior. (Am J Prev Med 2012;42(1):44-52) Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine C1 [Liddon, Nicole C.; Leichliter, Jami S.; Markowitz, Lauri E.] CDC, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. RP Liddon, NC (reprint author), CDC, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, 1600 Clifton Rd NE,Mailstop E-44, Atlanta, GA 30333 USA. EM nliddon@cdc.gov NR 21 TC 73 Z9 73 U1 4 U2 15 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2012 VL 42 IS 1 BP 44 EP 52 DI 10.1016/j.amepre.2011.09.024 PG 9 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 865EP UT WOS:000298294000009 PM 22176845 ER PT J AU Peterson, BA Gwinn, ML Valdez, RA AF Peterson, Brent A. Gwinn, Marta L. Valdez, Rodolfo A. TI Use of Family History in Clinical Guidelines for Diabetes and Colorectal Cancer SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID FORCE RECOMMENDATION STATEMENT; TASK-FORCE; AMERICAN-COLLEGE; SURVEILLANCE; SOCIETY; UPDATE; HEALTH; INFORMATION; PROSTATE AB Background: Family history is a risk factor for many chronic diseases and as such is often incorporated into clinical practice guidelines. Purpose: To assess the consistency of the use of family history in selected guidelines for colorectal cancer (CRC) and type 2 diabetes mellitus (T2DM) and to examine how these definitions influence their screening recommendations. Methods: Using a web-based search, guidelines issued between 2001 and 2011 from Australia, Canada, the United Kingdom, the U. S., and the WHO were reviewed. In total, 21 guidelines were found that included family history information (14 for CRC and seven for T2DM). For each guideline, the definition of family history and the way this definition influenced screening recommendations was recorded. Analyses were completed on May 2011. Results: Family history was defined most often as the presence of affected first-degree relatives; the number of such relatives and their ages at diagnosis were considered sometimes in making specific recommendations. The definition of family history and its impact on recommendations varied substantially, even for the same disease. Conclusions: Despite the importance of family history as a risk factor for CRC and T2DM, its use in screening recommendations is inconsistent among guidelines from major organizations; however, differences do not appear large enough to prevent achieving consensus among the guidelines for each disease. More standardized recommendations for use of family history in CRC and T2DM screening guidelines could enhance their utility for prevention. (Am J Prev Med 2012;42(1):65-70) Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine C1 [Valdez, Rodolfo A.] CDC, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Peterson, Brent A.] Wisconsin Lutheran Coll, Dept Biol, Milwaukee, WI USA. [Gwinn, Marta L.] McKing Consulting Corp, Atlanta, GA USA. RP Valdez, RA (reprint author), CDC, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS E88, Atlanta, GA 30333 USA. EM rvaldez@cdc.gov NR 33 TC 1 Z9 1 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2012 VL 42 IS 1 BP 65 EP 70 DI 10.1016/j.amepre.2011.08.017 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 865EP UT WOS:000298294000013 PM 22176849 ER PT J AU Khoury, MJ Gwinn, M Bowen, MS Dotson, WD AF Khoury, Muin J. Gwinn, Marta Bowen, M. Scott Dotson, W. David TI Beyond Base Pairs to Bedside: A Population Perspective on How Genomics Can Improve Health SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID PUBLIC-HEALTH; PERSONALIZED MEDICINE; EVIDENCE DILEMMA; OVARIAN-CANCER; PREVENTION; DISEASE; RECOMMENDATIONS; SUSCEPTIBILITY; PRIORITIES; THINKING AB A decade after the sequencing of the human genome, the National Human Genome Research Institute announced a strategic plan for genomic medicine. It calls for evaluating the structure and biology of genomes, understanding the biology of disease, advancing the science of medicine, and improving the effectiveness of health care. Fulfilling the promise of genomics urgently requires a population perspective to complement the bench-to-bedside model of translation. A population approach should assess the contribution of genomics to health in the context of social and environmental determinants of disease; evaluate genomic applications that may improve health care; design strategies for integrating genomics into practice; address ethical, legal, and social issues; and measure the population health impact of new technologies. (Am J Public Health. 2012;102:34-37. doi:10.2105/AJPH.2011.300299) C1 [Khoury, Muin J.; Gwinn, Marta; Bowen, M. Scott; Dotson, W. David] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA 30333 USA. RP Khoury, MJ (reprint author), Ctr Dis Control & Prevent, Off Publ Hlth Genom, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM muk1@cdc.gov OI Dotson, William David/0000-0002-9606-6594 NR 38 TC 19 Z9 19 U1 1 U2 9 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JAN PY 2012 VL 102 IS 1 BP 34 EP 37 DI 10.2105/AJPH.2011.300299 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 867IZ UT WOS:000298449400010 PM 22095352 ER PT J AU Lee, LM Heilig, CM White, A AF Lee, Lisa M. Heilig, Charles M. White, Angela TI Ethical Justification for Conducting Public Health Surveillance Without Patient Consent SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID AUTONOMY; PRIVACY AB Public health surveillance by necessity occurs without explicit patient consent. There is strong legal and scientific support for maintaining name-based reporting of infectious diseases and other types of public health surveillance. We present conditions under which surveillance without explicit patient consent is ethically justifiable using principles of contemporary clinical and public health ethics. Overriding individual autonomy must be justified in terms of the obligation of public health to improve population health, reduce inequities, attend to the health of vulnerable and systematically disadvantaged persons, and prevent harm. In addition, data elements collected without consent must represent the minimal necessary interference, lead to effective public health action, and be maintained securely. (Am J Public Health. 2012;102:38-44. doi: 10.2105/AJPH.2011.300297) C1 [Lee, Lisa M.] Ctr Dis Control & Prevent CDC, Off Surveillance Epidemiol & Lab Serv, Atlanta, GA USA. [Heilig, Charles M.] CDC, TB Trials Consortium, Div TB Eliminat, Atlanta, GA 30333 USA. [White, Angela] Univ Western Ontario, JL Rotman Inst Philosophy, London, ON, Canada. RP Lee, LM (reprint author), Ctr Dis Control & Prevent, OSELS, 1600 Clifton Rd NE,Mailstop E-94, Atlanta, GA 30333 USA. EM LMLee@cdc.gov RI Heilig, Charles/C-2753-2008 OI Heilig, Charles/0000-0003-1075-1310 NR 57 TC 14 Z9 14 U1 0 U2 8 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JAN PY 2012 VL 102 IS 1 BP 38 EP 44 DI 10.2105/AJPH.2011.300297 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 867IZ UT WOS:000298449400011 PM 22095338 ER PT J AU Dowell, D Tian, LH Stover, JA Donnelly, JA Martins, S Erbelding, EJ Pino, R Weinstock, H Newman, LM AF Dowell, Deborah Tian, Lin H. Stover, Jeffrey A. Donnelly, Jennifer A. Martins, Summer Erbelding, Emily J. Pino, Raul Weinstock, Hillard Newman, Lori M. TI Changes in Fluoroquinolone Use for Gonorrhea Following Publication of Revised Treatment Guidelines SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID SEXUALLY-TRANSMITTED-DISEASES; ANTIMICROBIAL RESISTANCE; UNITED-STATES; NEISSERIA-GONORRHOEAE; UPDATE; CARE AB Objectives. We evaluated the impact of revised national treatment recommendations on fluoroquinolone use for gonorrhea in selected states. Methods. We evaluated gonorrhea cases reported through the Sexually Transmitted Disease Surveillance Network as treated between July 1, 2006 and May 31, 2008, using interrupted time series analysis. Outcomes were fluoroquinolone treatment overall, by area, and by practice setting. Results. Of 16126 cases with treatment dates in this period, 15669 noted the medication used. After revised recommendations were released, fluoroquinolone use decreased abruptly overall (21.5%; 95% confidence interval [CI] = 15.9%, 27.2%), in most geographic areas evaluated, and in sexually transmitted disease clinics (28.5%; 95% CI=19.0%, 37.9%). More gradual decreases were seen in primary care (8.6%; 95% CI=2.6%, 14.6%), and in emergency departments, urgent care, and hospitals (2.7%; 95% CI=1.7%, 3.7%). Conclusions. Fluoroquinolone use decreased after the publication of revised national guidelines, particularly in sexually transmitted disease clinics. Additional mechanisms are needed to increase the speed and magnitude of changes in prescribing in primary care, emergency departments, urgent care, and hospitals. (Am J Public Health. 2012;102:148-155. doi:10.2105/AJPH.2011.300283) C1 [Dowell, Deborah; Tian, Lin H.; Weinstock, Hillard; Newman, Lori M.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Stover, Jeffrey A.] Virginia Dept Hlth, Div Dis Prevent, Richmond, VA USA. [Donnelly, Jennifer A.] Colorado Dept Publ Hlth & Environm, Denver, CO USA. [Martins, Summer] Minnesota Dept Hlth, STD & HIV Sect, St Paul, MN USA. [Erbelding, Emily J.] Baltimore City Dept Hlth, Baltimore, MD USA. [Pino, Raul] Connecticut Dept Publ Hlth, Hartford, CT USA. RP Weinstock, H (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,Mailstop E-02, Atlanta, GA 30333 USA. EM hsw2@cdc.gov NR 36 TC 13 Z9 13 U1 0 U2 2 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JAN PY 2012 VL 102 IS 1 BP 148 EP 155 DI 10.2105/AJPH.2011.300283 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 867IZ UT WOS:000298449400027 PM 22095341 ER PT J AU Ogunniyi, MO Holt, JB Croft, JB Nwaise, IA Okafor, HE Sawyer, DB Giles, WH Mensah, GA AF Ogunniyi, Modele O. Holt, James B. Croft, Janet B. Nwaise, Isaac A. Okafor, Henry E. Sawyer, Douglas B. Giles, Wayne H. Mensah, George A. TI Geographic Variations in Heart Failure Hospitalizations Among Medicare Beneficiaries in the Tennessee Catchment Area SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES LA English DT Article DE Geographic differences; Heart failure; Elderly; Medicare ID DISEASE MANAGEMENT; UNITED-STATES; COST-EFFECTIVENESS; DISPARITIES; GUIDELINES; ENROLLEES; ADHERENCE; MORTALITY; TRENDS; RATES AB Introduction: Although differences in heart failure (HF) hospitalization rates by race and sex are well documented, little is known about geographic variations in hospitalizations for HF, the most common discharge diagnosis for Medicare beneficiaries. Methods: Using exploratory spatial data analysis techniques, the authors examined hospitalization rates for HF as the first-listed discharge diagnosis among Medicare beneficiaries in a 10-state Tennessee catchment area, based on the resident states reported by Tennessee hospitals from 2000 to 2004. Results: The age-adjusted HF hospitalization rate (per 1000) among Medicare beneficiaries was 23.3 [95% confidence interval (CI), 23.3-23.4] for the Tennessee catchment area, 21.4 (95% CI, 21.4-21.5) outside the catchment area and 21.9 (95% CI, 21.9-22.0) for the overall United States. The age-adjusted HF hospitalization rates were also significantly higher in the catchment area than outside the catchment area and overall, among men, women and whites, whereas rates among the blacks were higher outside the catchment area. Beneficiaries in the catchment area also had higher age-specific HF hospitalization rates. Among states in the catchment area, the highest mean county-level rates were in Mississippi (30.6 +/- 7.6) and Kentucky (29.2 +/- 11.5), and the lowest were in North Carolina (21.7 +/- 5.7) and Virginia (21.8 +/- 6.6). Conclusions: Knowledge of these geographic differences in HF hospitalization rates can be useful in identifying needs of healthcare providers, allocating resources, developing comprehensive HF outreach programs and formulating policies to reduce these differences. C1 [Ogunniyi, Modele O.] Emory Univ, Div Cardiol, Dept Med, Sch Med, Atlanta, GA 30303 USA. [Ogunniyi, Modele O.; Holt, James B.; Croft, Janet B.; Nwaise, Isaac A.; Giles, Wayne H.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Okafor, Henry E.] Meharry Med Coll, Div Cardiovasc Med, Nashville, TN 37208 USA. [Sawyer, Douglas B.] Vanderbilt Univ, Med Ctr, Div Cardiovasc Med, Nashville, TN USA. [Mensah, George A.] PepsiCo Inc, Global Nutr Res & Dev, Purchase, NY USA. RP Ogunniyi, MO (reprint author), Emory Univ, Div Cardiol, Dept Med, Sch Med, 49 Jesse Hill Jr Dr SE, Atlanta, GA 30303 USA. EM modele.ogunniyi@emory.edu OI OGUNNIYI, MODELE/0000-0001-9545-3675; Mensah, George/0000-0002-0387-5326 FU Centers for Disease Control and Prevention FX This study was supported by the Centers for Disease Control and Prevention through an inter agency professional agreement with Dr. Ogunniyi. NR 30 TC 4 Z9 4 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0002-9629 J9 AM J MED SCI JI Am. J. Med. Sci. PD JAN PY 2012 VL 343 IS 1 BP 71 EP 77 DI 10.1097/MAJ.0b013e318223bbd4 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 870LK UT WOS:000298670600017 PM 21804374 ER PT J AU Brown, C Ripp, J Kazura, J AF Brown, Clive Ripp, Jonathan Kazura, James TI Perspectives on Haiti Two Years after the Earthquake SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article C1 [Brown, Clive] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA 30329 USA. [Ripp, Jonathan] Mt Sinai Sch Med, New York, NY USA. [Kazura, James] Case Western Reserve Univ, Ctr Global Hlth & Dis, Cleveland, OH 44106 USA. RP Brown, C (reprint author), Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, 1600 Clifton Rd,MS-E03, Atlanta, GA 30329 USA. EM cmb8@cdc.gov; jonathan.ripp@mountsinai.org; jxk14@case.edu NR 15 TC 3 Z9 3 U1 0 U2 15 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 2012 VL 86 IS 1 BP 5 EP 6 DI 10.4269/ajtmh.2012.11-0684a PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 875WF UT WOS:000299065200004 PM 22232440 ER PT J AU Agarwal, A McMorrow, M Arguin, PM AF Agarwal, Aarti McMorrow, Meredith Arguin, Paul M. TI The Increase of Imported Malaria Acquired in Haiti among US Travelers in 2010 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article AB From 2004 to 2009, the number of malaria cases reported in Haiti increased nearly fivefold. The effect of the 2010. earthquake and its aftermath on malaria transmission in Haiti is not known. Imported malaria cases in the United States acquired in Haiti tripled from 2009 to 2010, likely reflecting both the increased number of travelers arriving from Haiti and the increased risk of acquiring malaria infection in Haiti. The demographics of travelers and the proportion of severe cases are similar to those statistics reported in previous years. Non-adherence to malaria chemoprophylaxis remains a nearly universal modifiable risk factor among these cases. C1 [Agarwal, Aarti; McMorrow, Meredith; Arguin, Paul M.] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30341 USA. RP McMorrow, M (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Ctr Global Hlth, 4770 Buford Highway,MS F-22, Atlanta, GA 30341 USA. EM iyj8@cdc.gov; bwe3@cdc.gov; pma0@cdc.gov NR 8 TC 14 Z9 17 U1 0 U2 5 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 2012 VL 86 IS 1 BP 9 EP 10 DI 10.4269/ajtmh.2012.11-0394 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 875WF UT WOS:000299065200006 PM 22232442 ER PT J AU Sharp, TM Pillai, P Hunsperger, E Santiago, GA Anderson, T Vap, T Collinson, J Buss, BF Safranek, TJ Sotir, MJ Jentes, ES Munoz-Jordan, JL Arguello, DF AF Sharp, Tyler M. Pillai, Parvathy Hunsperger, Elizabeth Santiago, Gilberto A. Anderson, Teresa Vap, Trina Collinson, Jeremy Buss, Bryan F. Safranek, Thomas J. Sotir, Mark J. Jentes, Emily S. Munoz-Jordan, Jorge L. Arguello, D. Fermin TI A Cluster of Dengue Cases in American Missionaries Returning from Haiti, 2010 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID LINKED-IMMUNOSORBENT-ASSAY; HEMORRHAGIC-FEVER; IMMUNOGLOBULIN-G; VIRUS-INFECTION; TRAVELERS; CHILDREN; TRANSMISSION; ANTIBODIES; DIAGNOSIS; OUTBREAK AB Dengue is an acute febrile illness caused by four mosquito-borne dengue viruses (DENV-1 to -4) that are endemic throughout the tropics. After returning from a 1-week missionary trip to Haiti in October of 2010,5 of 28 (18%) travelers were hospitalized for dengue-like illness. All travelers were invited to submit serum specimens and complete questionnaires on pre-travel preparations, mosquito avoidance practices, and activities during travel. DENV infection was confirmed in seven (25%) travelers, including all travelers that were hospitalized. Viral sequencing revealed closest homology to a 2007 DENV-1 isolate from the Dominican Republic. Although most (88%) travelers had a pre-travel healthcare visit, only one-quarter knew that dengue is a risk in Haiti, and one-quarter regularly used insect repellent. This report confirms recent DENV transmission in Haiti. Travelers to DENV-endemic areas should receive dengue education during pre-travel health consultations, follow mosquito avoidance recommendations, and seek medical care for febrile illness during or after travel. C1 [Sharp, Tyler M.; Hunsperger, Elizabeth; Santiago, Gilberto A.; Munoz-Jordan, Jorge L.; Arguello, D. Fermin] Ctr Dis Control & Prevent, Dengue Branch, Div Vector Borne Dis, San Juan, PR 00920 USA. Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. [Pillai, Parvathy; Buss, Bryan F.; Safranek, Thomas J.] Nebraska Dept Hlth & Human Serv, Lincoln, NE USA. [Anderson, Teresa; Vap, Trina; Collinson, Jeremy] Cent Dist Hlth Dept, Grand Isl, NY USA. Ctr Dis Control & Prevent, Off Publ Hlth Preparedness & Response, Atlanta, GA USA. [Sotir, Mark J.; Jentes, Emily S.] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Travelers Hlth Branch, Atlanta, GA USA. RP Arguello, DF (reprint author), Ctr Dis Control & Prevent, Dengue Branch, Div Vector Borne Dis, 1324 Calle Canada, San Juan, PR 00920 USA. EM tsharp@cdc.gov; ihc9@cdc.gov; enh4@cdc.gov; fbz3@cdc.gov; tanderson@cdhd.ne.gov; tvap@cdhd.ne.gov; jcollinson@cdhd.ne.gov; feu7@cdc.gov; tom.safranek@nebraska.gov; mps6@cdc.gov; efj8@cdc.gov; ckq2@cdc.gov; darguello@cdc.gov NR 42 TC 13 Z9 15 U1 0 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 2012 VL 86 IS 1 BP 16 EP 22 DI 10.4269/ajtmh.2012.11-0427 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 875WF UT WOS:000299065200008 PM 22232444 ER PT J AU Esposito, DH Han, PV Kozarsky, PE Walker, PF Gkrania-Klotsas, E Barnett, ED Libman, M McCarthy, AE Field, V Connor, BA Schwartz, E MacDonald, S Sotir, MJ AF Esposito, Douglas H. Han, Pauline V. Kozarsky, Phyllis E. Walker, Patricia F. Gkrania-Klotsas, Effrossyni Barnett, Elizabeth D. Libman, Michael McCarthy, Anne E. Field, Vanessa Connor, Bradley A. Schwartz, Eli MacDonald, Susan Sotir, Mark J. CA GeoSentinel Surveillance Network TI Characteristics and Spectrum of Disease Among Ill Returned Travelers from Pre- and Post-Earthquake Haiti: The GeoSentinel Experience SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH; LATIN-AMERICA; EARTHQUAKE; DISASTER; DENGUE; SURVEILLANCE; CHILDREN; WORKERS; MALARIA AB To describe patient characteristics and disease spectrum among foreign visitors to Haiti before and after the 2010 earthquake, we used GeoSentinel Global Surveillance Network data and compared 1 year post-earthquake versus 3 years pre-earthquake. Post-earthquake travelers were younger, predominantly from the United States, more frequently international assistance workers, and more often medically counseled before their trip than pre-earthquake travelers. Work-related stress and upper respiratory tract infections were more frequent post-earthquake; acute diarrhea, dengue, and Plasmodium falciparum malaria were important contributors of morbidity both pre- and post-earthquake. These data highlight the importance of providing destination- and disaster-specific pre-travel counseling and post-travel evaluation and medical management to persons traveling to or returning from a disaster location, and evaluations should include attention to the psychological wellbeing of these travelers. For travel to Haiti, focus should be on mosquito-borne illnesses (dengue and P falcipartun malaria) and travelers' diarrhea. C1 [Esposito, Douglas H.] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Global Migrat & Quarantine, Travelers Hlth Branch, Atlanta, GA 30333 USA. [Kozarsky, Phyllis E.] Emory Univ, Sch Med, Div Infect Dis, Atlanta, GA USA. [Walker, Patricia F.] Univ Minnesota, HealthPartners Travel Med Clin, Minneapolis, MN USA. [Gkrania-Klotsas, Effrossyni] Univ Cambridge, Addenbrookes Hosp, Cambridge CB2 2QQ, England. [Barnett, Elizabeth D.] Boston City Hosp, Maxwell Finland Lab Infect Dis, Boston Med Ctr, Boston, MA 02118 USA. [Libman, Michael] McGill Univ, JD MacLean Ctr Trop Dis, Montreal, PQ, Canada. [McCarthy, Anne E.] Ottawa Hosp Gen Campus, Div Infect Dis, Ottawa, ON, Canada. [Field, Vanessa] InterHealth, London, England. [Connor, Bradley A.] Cornell Univ, Weill Med Coll, New York, NY 10021 USA. [Schwartz, Eli] Tel Aviv Univ, Ctr Geog Med, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Fac Med, IL-69978 Tel Aviv, Israel. [MacDonald, Susan] Univ Hosp No British Columbia, Prince George, BC, Canada. RP Esposito, DH (reprint author), Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Global Migrat & Quarantine, Travelers Hlth Branch, 1600 Clifton Rd NE,MS E-03, Atlanta, GA 30333 USA. EM desposito@cdc.gov; phan@cdc.gov; pkozars@emory.edu; patricia.f.walker@healthpartners.com; effrossyni.gkrania-klotsas@mrc-epid.cam.ac.uk; elizabeth.barnett@bmc.org; michael.libman@mcgill.ca; amccarthy@ottawahospital.on.ca; vanessafield@doctors.org.uk; bconnor@pol.net; elischwa@post.tau.ac.il; susanmacdonald@telus.net; msotir@cdc.gov OI Barnett, Elizabeth/0000-0003-4822-5949; McCarthy, Anne/0000-0001-7195-6366; Aoun, Olivier/0000-0001-9554-8439; Gkrania-Klotsas, Effrossyni/0000-0002-0930-8330 FU Centers for Disease Control and Prevention [5U50CI000359]; International Society of Travel Medicine; National Institute of Health Research Cambridge Biomedical Research Centre FX GeoSentinel is supported by a cooperative agreement (5U50CI000359) from the Centers for Disease Control and Prevention and an initial pilot grant from the International Society of Travel Medicine. The Cambridge UK Site is also supported by the National Institute of Health Research Cambridge Biomedical Research Centre. NR 34 TC 6 Z9 6 U1 0 U2 5 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 2012 VL 86 IS 1 BP 23 EP 28 DI 10.4269/ajtmh.2012.11-0430 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 875WF UT WOS:000299065200009 PM 22232445 ER PT J AU Townes, D Existe, A Boncy, J Magloire, R Vely, JF Amsalu, R De Tavernier, M Muigai, J Hoibak, S Albert, M McMorrow, M Slutsker, L Kachur, SP Chang, M AF Townes, David Existe, Alexandre Boncy, Jacques Magloire, Roc Vely, Jean-Francois Amsalu, Ribka De Tavernier, Marleen Muigai, James Hoibak, Sarah Albert, Michael McMorrow, Meredith Slutsker, Laurence Kachur, S. Patrick Chang, Michelle TI Malaria Survey in Post-Earthquake Haiti-2010 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article AB Haiti's Ministry of Public Health and Population collaborated with global partners to enhance malaria surveillance in two disaster-affected areas within 3 months of the January 2010 earthquake. Data were collected between March 4 and April 9, 2010 by mobile medical teams. Malaria rapid diagnostic tests (RDTs) were used for case confirmation. A convenience sample of 1,629 consecutive suspected malaria patients was included. Of these patients, 1,564 (96%) patients had malaria RDTs performed, and 317 (20.3%) patients were positive. Of the 317 case-patients with a positive RDT, 278 (87.7%) received chloroquine, 8 (2.5%) received quinine, and 31 (9.8%) had no antimalarial treatment recorded. Our experience shows that mobile medical teams trained in the use of malaria RDTs had a high rate of testing suspected malaria cases and that the majority of patients with positive RDTs received appropriate antimalarial treatment. Malaria RDTs were useful in the post-disaster setting where logistical and technical constraints limited the use of microscopy. C1 [Townes, David; McMorrow, Meredith; Slutsker, Laurence; Kachur, S. Patrick; Chang, Michelle] Ctr Dis Control & Prevent, Malaria Branch, Ctr Global Hlth, Atlanta, GA USA. [Existe, Alexandre; Boncy, Jacques] Minist Hlth & Populat, Natl Publ Hlth Lab, Port Au Prince, Haiti. [Magloire, Roc] Minist Hlth & Populat, Dept Epidemiol & Lab Res, Port Au Prince, Haiti. [Vely, Jean-Francois] Minist Hlth & Populat, Natl Malaria Control Program, Port Au Prince, Haiti. [Muigai, James] Save Children, Leogane, Haiti. [De Tavernier, Marleen] Save Children, Jacmel, Haiti. [Hoibak, Sarah; Albert, Michael] MENTOR Initiat, La Prade, France. RP Townes, D (reprint author), 1959 NE Pacific St,Box 356123, Seattle, WA 98195 USA. EM townesd@uw.edu; Alexandre.existe@gmail.com; Jboncy2001@yahoo.fr; Corgamsa368@hotmail.com; ramsalu@savechildren.org; mtavernier@savechildren.org; jmungai@savechildren.org; sarahhoibak@hotmail.com; michael.a.albert@gmail.com; bwe3@cdc.gov; lms5@cde.gov; spk0@cdc.gov; aup6@cdc.gov NR 5 TC 13 Z9 15 U1 0 U2 8 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 2012 VL 86 IS 1 BP 29 EP 31 DI 10.4269/ajtmh.2012.11-0431 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 875WF UT WOS:000299065200010 PM 22232446 ER PT J AU Faruque, LI Zaman, RU Alamgir, ASM Gurley, ES Haque, R Rahman, M Luby, SP AF Faruque, Labib I. Zaman, Rashid Uz Alamgir, A. S. M. Gurley, Emily S. Haque, Rashidul Rahman, Mahmudur Luby, Stephen P. TI Hospital-Based Prevalence of Malaria and Dengue in Febrile Patients in Bangladesh SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID LINKED-IMMUNOSORBENT-ASSAY; HEMORRHAGIC-FEVER; IMMUNOGLOBULIN-M; VIRUS-INFECTION; TAMIL-NADU; JAPANESE ENCEPHALITIS; RURAL INDONESIA; CAPTURE ELISA; THAI VILLAGES; EPIDEMIOLOGY AB We conducted a nationwide study at six tertiary hospitals from December 2008 through November 2009 to investigate etiologies of febrile illnesses in Bangladesh. Febrile patients meeting a clinical case definition were enrolled from inpatient and outpatient medicine and pediatric units. We assessed 720 febrile patients over 12 months; 69 (9.6%) were positive for IgM antibodies against dengue virus by enzyme-linked immunosorbent assay, and four malaria patients (0.56%) were confirmed with immuno-chromatography and microscopic slide tests. We identified dengue cases throughout the year from rural (49%) and urban areas (51%). We followed-up 55 accessible dengue-infected patients two months after their initial enrollment: 45 (82%) patients had fully recovered, 9 (16%) reported ongoing jaundice, fever and/or joint pain, and one died. Dengue infection is widespread across Bangladesh, but malaria is sufficiently uncommon that it should not be assumed as the cause of fever without laboratory confirmation. C1 [Faruque, Labib I.; Gurley, Emily S.; Haque, Rashidul; Luby, Stephen P.] Int Ctr Diarrhoeal Dis Res, Dhaka, Bangladesh. [Alamgir, A. S. M.; Rahman, Mahmudur] Govt Bangladesh, Inst Epidemiol Dis Control & Res, Minist Hlth & Family Welf, Dhaka, Bangladesh. [Luby, Stephen P.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Zaman, Rashid Uz] Oxford Policy Management, Oxford OX1 1BN, England. RP Faruque, LI (reprint author), Int Ctr Diarrhoeal Dis Res, Dhaka, Bangladesh. EM labibimran@yahoo.com; rashid.zaman@opml.co.uk; aalamgir@gmail.com; egurley@icddrb.org; rhaque@icddrb.org; mrahman@citechco.net; sluby@icddrb.org RI Gurley, Emily/B-7903-2010 OI Gurley, Emily/0000-0002-8648-9403 FU United States Centers for Disease Control and Prevention [5U51CI000298-05] FX This study was supported by the United States Centers for Disease Control and Prevention (grant no.5U51CI000298-05). ICDDR,B acknowledges with gratitude the commitment of the Centers for Disease Control and Prevention to the research efforts of ICDDR,B. NR 63 TC 11 Z9 12 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 2012 VL 86 IS 1 BP 58 EP 64 DI 10.4269/ajtmh.2012.11-0190 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 875WF UT WOS:000299065200016 PM 22232452 ER PT J AU Folkema, AM Holman, RC McQuiston, JH Cheek, JE AF Folkema, Arianne M. Holman, Robert C. McQuiston, Jennifer H. Cheek, James E. TI Trends in Clinical Diagnoses of Rocky Mountain Spotted Fever among American Indians, 2001-2008 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID INFECTIOUS-DISEASE HOSPITALIZATIONS; UNITED-STATES; ALASKA NATIVES; HEALTH-CARE; SURVEILLANCE; ARIZONA; EMERGENCE; EXPOSURE; OKLAHOMA; INFANTS AB American Indians are at greater risk for Rocky Mountain spotted fever (RMSF) than the general US. population. The epidemiology of RMSF among American Indians was examined by using Indian Health Service inpatient and outpatient records with an RMSF International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis. For 2001-2008,958 American Indian patients with clinical diagnoses of RMSF were reported. The average annual RMSF incidence was 94.6 per 1,000,000 persons, with a significant increasing incidence trend from 24.2 in 2001. to 139.4 in 2008 (P = 0.006). Most (89%) RMSF hospital visits occurred in the Southern Plains and Southwest regions, where the average annual incidence rates were 277.2 and 49.4, respectively. Only the Southwest region had a significant increasing incidence trend (P = 0.005), likely linked to the emergence of brown dog ticks as an RMSF vector in eastern Arizona. It is important to continue monitoring RMSF infection to inform public health interventions that target RMSF reduction in high-risk populations. C1 [Folkema, Arianne M.; Holman, Robert C.] Ctr Dis Control & Prevent, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. Ctr Dis Control & Prevent, Div Vector Borne Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [McQuiston, Jennifer H.] Ctr Dis Control & Prevent, Div Vectorborne Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Cheek, James E.] US Dept HHS, Div Epidemiol & Dis Prevent, Off Publ Hlth Support, Indian Hlth Serv Headquarters, Albuquerque, NM USA. RP Folkema, AM (reprint author), Ctr Dis Control & Prevent, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, 1600 Clifton Rd,Mailstop A30, Atlanta, GA 30333 USA. EM afolkema@cdc.gov; rholman@cdc.gov; jmcquiston@cdc.gov; james.cheek@ihs.gov NR 45 TC 8 Z9 9 U1 0 U2 8 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 2012 VL 86 IS 1 BP 152 EP 158 DI 10.4269/ajtmh.2012.11-0269 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 875WF UT WOS:000299065200029 PM 22232466 ER PT J AU Wolkin, AF Martin, CA Law, RK Schier, JG Bronstein, AC AF Wolkin, Amy F. Martin, Colleen A. Law, Royal K. Schier, Josh G. Bronstein, Alvin C. TI Using Poison Center Data for National Public Health Surveillance for Chemical and Poison Exposure and Associated Illness SO ANNALS OF EMERGENCY MEDICINE LA English DT Article AB The National Poison Data System (NPDS) is a national near-real-time surveillance system that improves situational awareness for chemical and poison exposures, according to data from US poison centers. NPDS is the successor to the Toxic Exposure Surveillance System. The Centers for Disease Control and Prevention (CDC) use these data, which are owned and managed by the American Association of Poison Control Centers, to improve public health surveillance for chemical and poison exposures and associated illness, identify early markers of chemical events, and enhance situational awareness during outbreaks. Information recorded in this database is from self-reported calls from the public or health care professionals. In 2009, NPDS detected 22 events of public health significance and CDC used the system to monitor several multistate outbreaks. One of the limitations of the system is that exposures do not necessarily represent a poisoning. Incorporating NPDS data into the public health surveillance network and subsequently using NPDS to rapidly identify chemical and poison exposures exemplifies the importance of the poison centers and NPDS to public health surveillance. This integration provides the opportunity to improve the public health response to chemical and poison exposures, minimizes morbidity and mortality, and serves as an important step forward in surveillance technology and integration. [Ann Emerg Med. 2012;59:56-61.] C1 [Wolkin, Amy F.; Martin, Colleen A.; Law, Royal K.; Schier, Josh G.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Agency Tox Subst & Dis Registry, Atlanta, GA 30341 USA. [Bronstein, Alvin C.] Amer Assoc Poison Control Ctr, Alexandria, VA USA. RP Wolkin, AF (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Agency Tox Subst & Dis Registry, Atlanta, GA 30341 USA. EM awolkin@cdc.gov RI Schier, Joshua/F-9861-2013 NR 10 TC 16 Z9 17 U1 0 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD JAN PY 2012 VL 59 IS 1 BP 56 EP 61 DI 10.1016/j.annemergmed.2011.08.004 PG 6 WC Emergency Medicine SC Emergency Medicine GA 873OX UT WOS:000298893800015 PM 21937144 ER PT J AU Goodman, M Steenland, NK Almon, ML Liff, JS Dilorio, CK Butler, SO Ekwueme, DU Hall, IJ Smith, JL Master, VA Roberts, PL AF Goodman, M. Steenland, N. K. Almon, M. L. Liff, J. S. Dilorio, C. K. Butler, S. O. Ekwueme, D. U. Hall, I. J. Smith, J. Lee Master, V. A. Roberts, P. L. TI Prostate cancer treatment ascertained from several sources: analysis of disagreement and error SO ANNALS OF ONCOLOGY LA English DT Article DE accuracy; prostate cancer; reliability; self-report; treatment ID QUALITY-OF-LIFE; ACTIVE SURVEILLANCE; OUTCOMES AB Background: Treatment data for prostate cancer can be obtained from a variety of sources. Each of these sources has its own strengths and weaknesses and is subject to error. Materials and methods: In a population-based cohort of 319 prostate cancer patients, data on treatment were obtained from five sources: two patient interviews at 6 and 12 months after diagnosis, primary caregiver interviews, physician questionnaires, and medical records. Inter-reporting agreement and accuracy of reporting (compared with medical records) were assessed. Multivariate analyses examined patient, caregiver, and physician characteristics as determinants of reporting error. Results: The agreement among different reporting methods was generally good to excellent for prostatectomy and brachytherapy (kappa range 0.70-0.90) and fair to good (kappa range 0.35-0.75) for external beam radiation and hormonal treatment. Compared with medical records, the interview-and questionnaire-based data collection methods were more accurate for prostatectomy and brachytherapy than for external beam radiation and hormonal therapy. Using medical records as the 'gold standard', patient and caregiver interviews at 6 months after the diagnosis had higher sensitivity and specificity than other reporting sources. Conclusion: Interviews of prostate cancer patients and caregivers are useful alternatives to medical record abstraction, particularly if carried out during, or soon after, treatment. C1 [Goodman, M.; Liff, J. S.] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Goodman, M.; Almon, M. L.; Liff, J. S.] Georgia Comprehens Canc Registry, Atlanta, GA USA. [Steenland, N. K.] Emory Univ, Rollins Sch Publ Hlth, Dept Environm & Occupat Hlth, Atlanta, GA 30322 USA. [Dilorio, C. K.; Butler, S. O.] Emory Univ, Rollins Sch Publ Hlth, Dept Behav Sci & Hlth Educ, Atlanta, GA 30322 USA. [Ekwueme, D. U.; Hall, I. J.; Smith, J. Lee] Emory Univ, Sch Med, Div Canc Prevent & Control, Ctr Dis Control, Atlanta, GA 30322 USA. [Ekwueme, D. U.; Hall, I. J.; Smith, J. Lee] Emory Univ, Sch Med, Div Canc Prevent & Control, Ctr Prevent, Atlanta, GA 30322 USA. [Master, V. A.] Emory Univ, Sch Med, Dept Urol, Atlanta, GA 30322 USA. [Roberts, P. L.] SW Georgia Canc Coalit, Albany, NY USA. RP Goodman, M (reprint author), Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, 1518 Clifton Rd,NE, Atlanta, GA 30322 USA. EM mgoodm2@sph.emory.edu FU Centers for Disease Control and Prevention [SIP 25-04, 3 U48 DP000043-01S1] FX Cooperative Agreement Number SIP 25-04 (grant 3 U48 DP000043-01S1) from the Centers for Disease Control and Prevention. NR 19 TC 1 Z9 1 U1 0 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0923-7534 J9 ANN ONCOL JI Ann. Oncol. PD JAN PY 2012 VL 23 IS 1 BP 256 EP 263 DI 10.1093/annonc/mdr040 PG 8 WC Oncology SC Oncology GA 866MO UT WOS:000298385300038 PM 21471565 ER PT J AU Urich, SK Chalcraft, L Schriefer, ME Yockey, BM Petersen, JM AF Urich, Sandra K. Chalcraft, Linda Schriefer, Martin E. Yockey, Brook M. Petersen, Jeannine M. TI Lack of Antimicrobial Resistance in Yersinia pestis Isolates from 17 Countries in the Americas, Africa, and Asia SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID BACTERIAL COMMUNITIES; MULTIDRUG-RESISTANCE; TRANSFERABLE PLASMID; PLAGUE; VECTORS; FUTURE; FLEAS AB Yersinia pestis is the causative agent of plague, a fulminant disease that is often fatal without antimicrobial treatment. Plasmid (IncA/C)-mediated multidrug resistance in Y. pestis was reported in 1995 in Madagascar and has generated considerable public health concern, most recently because of the identification of IncA/C multidrug-resistant plasmids in other zoonotic pathogens. Here, we demonstrate no resistance in 392 Y. pestis isolates from 17 countries to eight antimicrobials used for treatment or prophylaxis of plague. C1 [Urich, Sandra K.; Chalcraft, Linda; Schriefer, Martin E.; Yockey, Brook M.; Petersen, Jeannine M.] Ctr Dis Control & Prevent, Bacterial Dis Branch, Div Vector Borne Dis, Natl Ctr Emerging & Zoonot Infect Dis, Ft Collins, CO USA. RP Petersen, JM (reprint author), Ctr Dis Control & Prevent, Bacterial Dis Branch, Div Vector Borne Dis, Natl Ctr Emerging & Zoonot Infect Dis, Ft Collins, CO USA. EM nzp0@cdc.gov NR 23 TC 8 Z9 8 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JAN PY 2012 VL 56 IS 1 BP 555 EP 558 DI 10.1128/AAC.05043-11 PG 4 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 866TB UT WOS:000298404900069 PM 22024826 ER PT J AU Leach, CR Klabunde, CN Alfano, CM Smith, JL Rowland, JH AF Leach, Corinne R. Klabunde, Carrie N. Alfano, Catherine M. Smith, Judith Lee Rowland, Julia H. TI Physician over-recommendation of mammography for terminally ill women SO CANCER LA English DT Article DE breast cancer; mammography; primary care; practice guidelines; screening ID PRIMARY-CARE-PHYSICIANS; CANCER SCREENING RECOMMENDATIONS; UNITED-STATES; OLDER WOMEN; SOCIETY GUIDELINES; LUNG-CANCER; BREAST; PATIENT; SURVIVAL; ISSUES AB BACKGROUND: There has been recent, sometimes intense, debate about when to begin screening and how often to screen women for breast cancer with mammography. However, there should be no controversy regarding screening women who are unlikely to benefit from the procedure, such as those with a serious, life-limiting illness who would not live long enough to benefit from the potential detection and treatment of breast cancer. Identifying characteristics of physicians who recommend mammography for terminally ill women can help guide efforts to minimize patient risks and make better use of health care resources. METHODS: The authors used data from a nationally representative survey of primary care physicians (PCPs) (N = 1196; response rate, 67.5%) conducted in 2006 and 2007 to examine PCPs' breast cancer screening recommendations for hypothetical patients ages 50 years, 65 years, and 80 years who were healthy, had a moderate comorbidity, or had a terminal comorbidity. RESULTS: Many PCPs (47.7%) reported that they would recommend mammography to a woman aged 50 years, 65 years, or 80 years with terminal lung cancer, indicating over-recommendation. Physician characteristics associated with over-recommending mammography included obstetrician/gynecologist (odds ratio [OR], 1.69) or internal medicine (OR, 0.45) specialty, being a woman (OR, 1.40), being a racial/ethnic minority (OR, 1.72), and working in a smaller practice (OR, 1.41). CONCLUSIONS: The current results indicated that physician over-recommendation of screening mammography among terminally ill women is common. Certain physician and practice characteristics, including specialty, were associated with over-recommending mammography. The authors concluded that an informed and shared mammography decisionmaking process for terminally ill women may eliminate unnecessary patient risks and health care expenditures. Cancer 2012; 118: 27-37. (C) 2011 American Cancer Society. C1 [Leach, Corinne R.] Amer Canc Soc, Behav Res Ctr, Atlanta, GA 30303 USA. [Leach, Corinne R.; Alfano, Catherine M.; Rowland, Julia H.] NCI, Off Canc Survivorship, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. [Klabunde, Carrie N.] NCI, Appl Res Program, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. [Smith, Judith Lee] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA USA. RP Leach, CR (reprint author), Amer Canc Soc, Behav Res Ctr, 250 Williams St, Atlanta, GA 30303 USA. EM corinne.leach@cancer.org FU National Cancer Institute [N02-PC-51,308]; Centers for Disease Control and Prevention [Y3-PC-6017-01]; Agency for Healthcare Research and Quality [Y3-PC-5019-01, Y3-PC-5019-02] FX Funding support for this study was provided by the National Cancer Institute (contract N02-PC-51,308), the Centers for Disease Control and Prevention (interagency agreement Y3-PC-6017-01), and the Agency for Healthcare Research and Quality (interagency agreements Y3-PC-5019-01 and Y3-PC-5019-02). NR 41 TC 10 Z9 10 U1 0 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0008-543X J9 CANCER-AM CANCER SOC JI Cancer PD JAN 1 PY 2012 VL 118 IS 1 BP 27 EP 37 DI 10.1002/cncr.26233 PG 11 WC Oncology SC Oncology GA 868TW UT WOS:000298549700006 PM 21681736 ER PT J AU Ford, ES Mannino, DM Zhao, GX Li, CY Croft, JB AF Ford, Earl S. Mannino, David M. Zhao, Guixiang Li, Chaoyang Croft, Janet B. TI Changes in Mortality Among US Adults With COPD in Two National Cohorts Recruited From 1971-1975 and 1988-1994 SO CHEST LA English DT Article ID OBSTRUCTIVE PULMONARY-DISEASE; NUTRITION EXAMINATION SURVEY; RESTRICTIVE LUNG-DISEASE; PNEUMOCOCCAL VACCINATION; RISK-FACTORS; FOLLOW-UP; HEALTH; MANAGEMENT; EXACERBATIONS; METAANALYSIS AB Background: COPD is a major contributor to the global burden of disease. Our objective was to examine changes in the mortality rate among persons with COPD in the United States. Methods: We conducted prospective studies using data from 5,185 participants in the National Health and Nutrition Examination Survey (NHANES) I Epidemiologic Follow-up Study (baseline examination from 1971-1975; follow-up from 1992-1993) and 10,954 participants of the NHANES III Linked Mortality Study (baseline examination from 1988-1994; follow-up through 2006). Results: The age-adjusted rate (per 1,000 person-years) among participants with moderate or severe COPD (23.9 and 20.2) was about 2.5 to 3 times higher than the rate among participants with normal lung function (10.4 and 6.2) in NHANES I and NHANES III, respectively. Compared with NHANES I, the mortality rate among participants in NHANES III decreased by 15.8% for those with moderate or severe COPD, 25.2% for those with mild COPD, 35.9% for those with respiratory symptoms with normal lung function, 16.6% for those with restrictive impairment, and 40.1% for those with normal lung function. However, the decrease did not reach statistical significance among participants with moderate or severe COPD. The decreases in the mortality rate among men with moderate or severe COPD (-17.8%) or with restrictive impairment (-35.1%) exceeded the changes among women (+3% and -6.1%, respectively). Conclusions: The secular decline in the mortality rate in the United States benefited people with COPD less than those with normal lung function. CHEST 2012; 141(1):101-110 C1 [Ford, Earl S.; Zhao, Guixiang; Croft, Janet B.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Adult & Community Hlth, Atlanta, GA 30341 USA. [Li, Chaoyang] Ctr Dis Control & Prevent, Publ Hlth Surveillance Program Off, Div Behav Surveillance, Atlanta, GA 30341 USA. [Mannino, David M.] Univ Kentucky, Coll Med, Dept Med, Lexington, KY USA. RP Ford, ES (reprint author), Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Adult & Community Hlth, 4770 Buford Hwy,MS K67, Atlanta, GA 30341 USA. EM eford@cdc.gov OI Mannino, David/0000-0003-3646-7828 FU GlaxoSmithKline PLC; Novartis Pharmaceuticals; Pfizer Inc; AstraZeneca PLC; Forest Laboratories Inc; Creative Educational Concepts FX The authors have reported to CHEST the following conflicts of interest: Dr Mannino has received honoraria and consulting fees and served on speaker bureaus for GlaxoSmithKline PLC, Novartis Pharmaceuticals, Pfizer Inc, AstraZeneca PLC, Forest Laboratories Inc, and Creative Educational Concepts. Furthermore, he has received royalties from Up-to-Date. Drs Ford, Zhao, Li, and Croft have reported that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article. NR 31 TC 22 Z9 24 U1 0 U2 5 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD JAN PY 2012 VL 141 IS 1 BP 101 EP 110 DI 10.1378/chest.11-0472 PG 10 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 874FW UT WOS:000298941800019 PM 21700689 ER PT J AU Kapasi, A Meade, BD Plikaytis, B Pawloski, L Martin, MD Yoder, S Rock, MT Coddens, S Haezebroeck, V Fievet-Groyne, F Bixler, G Jones, C Hildreth, S Edwards, KM Messonnier, NE Tondella, ML AF Kapasi, Aditi Meade, Bruce D. Plikaytis, Brian Pawloski, Lucia Martin, Monte D. Yoder, Sandra Rock, Michael T. Coddens, Severine Haezebroeck, Valerie Fievet-Groyne, Francoise Bixler, Garvin Jones, Charles Hildreth, Stephen Edwards, Kathryn M. Messonnier, Nancy E. Tondella, Maria L. TI Comparative Study of Different Sources of Pertussis Toxin (PT) as Coating Antigens in IgG Anti-PT Enzyme-Linked Immunosorbent Assays SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID EUROPEAN-SEROEPIDEMIOLOGY-NETWORK; BORDETELLA-PERTUSSIS; SEROLOGIC ASSAYS; UNITED-STATES; DIAGNOSIS; STANDARDIZATION; ANTIBODIES; INFECTION; VACCINATION; MASSACHUSETTS AB In an effort to improve the reliability and reproducibility of serological assays for Bordetella pertussis, a collaborative study was conducted to compare four different sources of pertussis toxin (PT) as coating antigens in the immunoglobulin G (IgG) anti-PT enzyme-linked immunosorbent assay (ELISA). Four sources of PT were used as coating antigens in the IgG anti-PT ELISA in four different testing laboratories (labs A to D) to determine whether the different antigen preparations and different laboratories influenced assay results. A panel of 60 sera consisting of deidentified human specimens from previous vaccination trials of healthy adults and infants and clinical specimens from outbreak settings was tested. In the four laboratories, each sample was tested three times with the four PT antigens according to the standard coating optimization and IgG anti-PT ELISA testing procedures used in that laboratory. Differences among the antigens, as well as intra-and interlaboratory variability, were evaluated. Excellent agreement was observed with the test panel results among the four antigens within each laboratory. Concordance correlation coefficient (r(c)) measurements among the different antigens ranged from 0.99, 0.99 to 1.00, 1.00, and 0.97 to 1.00 for labs A to D, respectively. The comparisons between pairs of laboratories also indicated a high degree of concordance for each PT preparation, with r(c) measurements between 0.90 and 0.98, 0.93 and 0.99, 0.92 and 0.98, and 0.93 and 0.99 for antigens 1 to 4, respectively. Relatively minor differences in results were observed among laboratories or among antigens, suggesting that the four PT antigens are quite similar and could be considered for acceptance in harmonized immunoassays used for serodiagnosis or vaccine evaluation. C1 [Kapasi, Aditi; Plikaytis, Brian; Pawloski, Lucia; Martin, Monte D.; Messonnier, Nancy E.; Tondella, Maria L.] Ctr Dis Control & Prevent, Div Bacterial Dis, NCIRD, Atlanta, GA 30333 USA. [Yoder, Sandra; Rock, Michael T.; Edwards, Kathryn M.] Vanderbilt Univ Sch Med, Dept Pediat, Nashville, TN USA. [Bixler, Garvin; Jones, Charles; Hildreth, Stephen] Sanofi Pasteur, Swiftwater, PA USA. [Coddens, Severine; Haezebroeck, Valerie; Fievet-Groyne, Francoise] GlaxoSmithKline Biol, Rixensart, Belgium. [Meade, Bruce D.] Meade Biol LLC, Hillsborough, NC USA. RP Tondella, ML (reprint author), Ctr Dis Control & Prevent, Div Bacterial Dis, NCIRD, Atlanta, GA 30333 USA. EM mlt5@cdc.gov FU National Vaccine Program Office FX Parts of this study were funded by a grant from the National Vaccine Program Office. NR 29 TC 11 Z9 11 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD JAN PY 2012 VL 19 IS 1 BP 64 EP 72 DI 10.1128/CVI.05460-11 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 870NA UT WOS:000298675000011 PM 22116688 ER PT J AU Ferdinands, JM Shay, DK AF Ferdinands, Jill M. Shay, David K. TI Magnitude of Potential Biases in a Simulated Case-Control Study of the Effectiveness of Influenza Vaccination SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID SEASONAL INFLUENZA; MORTALITY BENEFITS; CONTROLLED-TRIAL; HEALTHY-ADULTS; EFFICACY; VACCINES; CHILDREN; PREVENTION; DESIGNS; HOSPITALIZATIONS AB Background. Many influenza vaccine effectiveness estimates have been made using case-control methods. Although several forms of bias may distort estimates of vaccine effectiveness derived from case-control studies, there have been few attempts to quantify the magnitude of these biases. Methods. We estimated the magnitude of potential biases in influenza vaccine effectiveness values derived from case-control studies from several factors, including bias from differential use of diagnostic testing based on influenza vaccine status, imperfect diagnostic test characteristics, and confounding. A decision tree model was used to simulate an influenza vaccine effectiveness case-control study in children. Using probability distributions, we varied the value of factors that influence vaccine effectiveness estimates, including diagnostic test characteristics, vaccine coverage, likelihood of receiving a diagnostic test for influenza, likelihood that a child hospitalized with acute respiratory infection had influenza, and others. Bias was measured as the difference between the effectiveness observed in the simulated case-control study and a true underlying effectiveness value. Results and Conclusions. We found an average difference between observed and true vaccine effectiveness of -11.9%. Observed vaccine effectiveness underestimated the true effectiveness in 88% of model iterations. Diagnostic test specificity exhibited the strongest association with observed vaccine effectiveness, followed by the likelihood of receiving a diagnostic test based on vaccination status and the likelihood that a child hospitalized with acute respiratory infection had influenza. Our findings suggest that the potential biases in case-control studies that we examined tend to result in underestimates of true influenza vaccine effects. C1 [Ferdinands, Jill M.; Shay, David K.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA. [Ferdinands, Jill M.] Battelle Mem Inst, Atlanta, GA USA. RP Ferdinands, JM (reprint author), Ctr Dis Control & Prevent, Influenza Div, 1600 Clifton Rd NE,MS A-32, Atlanta, GA 30333 USA. EM jferdinands@cdc.gov OI Shay, David/0000-0001-9619-4820 FU Centers for Disease Control and Prevention FX This work was sponsored by the Centers for Disease Control and Prevention. NR 40 TC 15 Z9 17 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JAN 1 PY 2012 VL 54 IS 1 BP 25 EP 32 DI 10.1093/cid/cir750 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 866LX UT WOS:000298383500007 PM 22095567 ER PT J AU Funnell, MM Brown, TL Childs, BP Haas, LB Hosey, GM Jensen, B Maryniuk, M Peyrot, M Piette, JD Reader, D Siminerio, LM Weinger, K Weiss, MA AF Funnell, Martha M. Brown, Tammy L. Childs, Belinda P. Haas, Linda B. Hosey, Gwen M. Jensen, Brian Maryniuk, Melinda Peyrot, Mark Piette, John D. Reader, Diane Siminerio, Linda M. Weinger, Katie Weiss, Michael A. TI National Standards for Diabetes Self-Management Education SO DIABETES CARE LA English DT Review ID RANDOMIZED CONTROLLED-TRIAL; CHRONIC DISEASE MANAGEMENT; IMPROVE GLYCEMIC CONTROL; PRIMARY-CARE PATIENTS; HEALTH-CARE; COMPLICATIONS TRIAL; PATIENT EDUCATION; AFRICAN-AMERICAN; COMMUNITY-HEALTH; CHRONIC ILLNESS C1 [Funnell, Martha M.] Univ Michigan, Dept Med Educ, Ctr Diabet Res & Training, Ann Arbor, MI 48109 USA. [Brown, Tammy L.] Indian Hlth Serv, Albuquerque, NM USA. [Childs, Belinda P.] MidAmer Diabet Associates, Wichita, KS USA. [Haas, Linda B.] VA Puget Sound Hlth Care Syst, Seattle, WA USA. [Hosey, Gwen M.] Ctr Dis Control & Prevent, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Jensen, Brian] Lakeshore Apothacare, Two Rivers, WI USA. [Maryniuk, Melinda; Weinger, Katie] Harvard Univ, Sch Med, Joslin Diabet Ctr, Boston, MA 02115 USA. [Peyrot, Mark] Loyola Coll, Baltimore, MD 21210 USA. [Piette, John D.] VA Ann Arbor Hlth Care Syst, Ann Arbor, MI USA. [Piette, John D.] Univ Michigan, Dept Internal Med, Ctr Diabet Res & Training, Ann Arbor, MI 48109 USA. [Reader, Diane] Int Diabet Ctr, Minneapolis, MN USA. [Siminerio, Linda M.] Univ Pittsburgh, Med Ctr, Inst Diabet, Pittsburgh, PA USA. [Weiss, Michael A.] Patient Ctr Solut, Pittsburgh, PA USA. RP Funnell, MM (reprint author), Univ Michigan, Dept Med Educ, Ctr Diabet Res & Training, Ann Arbor, MI 48109 USA. EM mfunnell@umich.edu FU National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health [NIH5P60 DK20572, 1 R18 0K062323]; American Diabetes Association; American Association of Diabetes Educators FX Work on this article was supported in part by grant nos. NIH5P60 DK20572 and 1 R18 0K062323 from the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health.; The Task Force gratefully acknowledges the assistance and support of Paulina Duker, MPH, APRN-BC, CDE, and Nathanial Clark, MD, CDE, of the American Diabetes Association; Lori Porter, MBA, RD, CAE, of the American Association of Diabetes Educators; and Karmeen Kulkami, MS, RD, BC-ADM, Past President, Health Care and Education of the American Diabetes Association; Malincla Peeples, MS, RN, CDE, Past President of the American Association of Diabetes Educators; and Carole' Mensing, RN, MA, CDE, for their insights and helpful suggestions. NR 164 TC 78 Z9 78 U1 3 U2 19 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 EI 1935-5548 J9 DIABETES CARE JI Diabetes Care PD JAN PY 2012 VL 35 IS 1 SU 1 BP S101 EP S108 DI 10.2337/dc12-S089 PG 8 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 871XY UT WOS:000298772200010 PM 22187467 ER PT J AU Yi-Frazier, JP Hood, K Case, D Waitzfelder, B Anderson, A Bloch, CA Naughton, M Seid, M Imperatore, G Loots, B Bell, R Lawrence, JM AF Yi-Frazier, Joyce P. Hood, Korey Case, Doug Waitzfelder, Beth Anderson, Andrea Bloch, Clifford A. Naughton, Michelle Seid, Michael Imperatore, Giuseppina Loots, Beth Bell, Ronny Lawrence, Jean M. CA SEARCH Diabet Youth Study Grp TI Caregiver reports of provider recommended frequency of blood glucose monitoring and actual testing frequency for youth with type 1 diabetes SO DIABETES RESEARCH AND CLINICAL PRACTICE LA English DT Article DE Blood glucose monitoring; Adherence; Type 1 diabetes; Youth ID DEPRESSIVE SYMPTOMS; YOUNG ADOLESCENTS; METABOLIC-CONTROL; MELLITUS; SEARCH; PREVALENCE; PREDICTORS; MANAGEMENT AB Aims: To identify demographic, family and clinical characteristics associated with provider recommended frequency of blood glucose monitoring (BGM), actual frequency of BGM, and concordance between these categories in youth with type 1 diabetes (T1D) as reported by child's caregiver. Methods: Caregivers of 390 children 10-17 years were interviewed about their children's providers' recommendations for frequency of BGM and their child's frequency of performance of BGM. Results: The majority (92%) of caregivers reported being told that their child should BGM >= 4 times per day and 78% reported their child checked that frequently. Caregivers of children who were younger, non-Hispanic White, from two-parent households, higher income households, and on insulin pumps were more likely to report being told by their provider to perform BGM >= 6 times per day and more likely to report that their child performed BGM >= 6 times per day. Younger children and those with private health insurance were more likely to adhere to reported recommendations. Children whose caregivers reported that their child met/exceeded their provider recommendations had lower A1c values than those who did not. Conclusions: These findings may help clinicians identify subgroups of youth at-risk for poor diabetes management and provide further education in order to improve outcomes. (C) 2011 Elsevier Ireland Ltd. All rights reserved. C1 [Yi-Frazier, Joyce P.] Univ Washington, Sch Med, Dept Pediat, Seattle, WA 98105 USA. [Yi-Frazier, Joyce P.; Loots, Beth] Seattle Childrens Res Inst, Dept Endocrinol, Seattle, WA 98101 USA. [Hood, Korey; Seid, Michael] Cincinnati Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA. [Case, Doug; Anderson, Andrea; Naughton, Michelle; Bell, Ronny] Wake Forest Univ, Bowman Gray Sch Med, Div Publ Hlth Sci, Winston Salem, NC 27157 USA. [Waitzfelder, Beth] Kaiser Permanente Ctr Hlth Res, Honolulu, HI 96817 USA. [Bloch, Clifford A.] Pediat Endocrine Associates PC, Greenwood Village, CO 80111 USA. [Imperatore, Giuseppina] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA 30341 USA. [Lawrence, Jean M.] Kaiser Permanente So Calif, Dept Res & Evaluat, Pasadena, CA 91101 USA. RP Yi-Frazier, JP (reprint author), Univ Washington, Sch Med, Dept Pediat, Seattle Childrens Res Inst, 1900 9th Ave,C9S-10, Seattle, WA 98101 USA. EM joyce.yi-frazier@seattlechildrens.org FU Centers for Disease Control and Prevention [00097, DP-05-069, DP-10-001]; National Institute of Diabetes and Digestive and Kidney Diseases; Kaiser Permanente Southern California [U48/CCU919219, U01 DP000246, U18DP002714]; University of Colorado Denver [U48/CCU819241-3, U01 DP000247, U18DP000247-06A1]; Kuakini Medical Center [U58CCU919256, U01 DP000245]; Children's Hospital Medical Center (Cincinnati) [U48/CCU519239, U01 DP000248, 1U18DP002709]; University of North Carolina at Chapel Hill [U48/CCU419249, U01 DP000254, U18DP002708-01]; University of Washington School of Medicine [U58/CCU019235-4, U01 DP000244, U18DP002710-01]; Wake Forest University School of Medicine [U48/CCU919219, U01 DP000250, 200-201035171]; NIH/NCRR [UL1RR029882]; Children's Hospital and Regional Medical Center [M01RR00037]; Colorado Pediatric General Clinical Research Center [M01 RR00069]; Barbara Davis Center at the University of Colorado at Denver [DERC NIH P30 DK57516]; NIH/NCRR at the University of Cincinnati [1UL1RR026314-01] FX SEARCH for Diabetes in Youth is funded by the Centers for Disease Control and Prevention (PA numbers 00097, DP-05-069, and DP-10-001) and supported by the National Institute of Diabetes and Digestive and Kidney Diseases.; Site Contract Numbers: Kaiser Permanente Southern California (U48/CCU919219, U01 DP000246, and U18DP002714), University of Colorado Denver (U48/CCU819241-3, U01 DP000247, and U18DP000247-06A1), Kuakini Medical Center (U58CCU919256 and U01 DP000245), Children's Hospital Medical Center (Cincinnati) (U48/CCU519239, U01 DP000248, and 1U18DP002709), University of North Carolina at Chapel Hill (U48/CCU419249, U01 DP000254, and U18DP002708-01), University of Washington School of Medicine (U58/CCU019235-4, U01 DP000244, and U18DP002710-01), Wake Forest University School of Medicine (U48/CCU919219, U01 DP000250, and 200-201035171).; The authors wish to acknowledge the involvement of General Clinical Research Centers (GCRC) at the South Carolina Clinical and Translational Research (SCTR) Institute, at the Medical University of South Carolina (NIH/NCRR Grant number UL1RR029882); Children's Hospital and Regional Medical Center (Grant Number M01RR00037); Colorado Pediatric General Clinical Research Center (Grant Number M01 RR00069) and the Barbara Davis Center at the University of Colorado at Denver (DERC NIH P30 DK57516); and the Institutional Clinical and Translational Science Award (CTSA), NIH/NCRR at the University of Cincinnati (Grant Number 1UL1RR026314-01). NR 24 TC 1 Z9 1 U1 0 U2 2 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0168-8227 J9 DIABETES RES CLIN PR JI Diabetes Res. Clin. Pract. PD JAN PY 2012 VL 95 IS 1 BP 68 EP 75 DI 10.1016/j.diabres.2011.08.026 PG 8 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 866ST UT WOS:000298403900019 PM 21940061 ER PT J AU Chadambuka, A Chimusoro, A Apollo, T Tshimanga, M Namusisi, O Luman, ET AF Chadambuka, Addmore Chimusoro, Anderson Apollo, Tsitsilina Tshimanga, Mufuta Namusisi, Olivia Luman, Elizabeth T. TI The need for innovative strategies to improve immunisation services in rural Zimbabwe SO DISASTERS LA English DT Article DE dropout rate; Gokwe South; immunisation; Midlands Province; vaccination coverage; Zimbabwe ID HEALTH; COVERAGE AB Gokwe South, a rural district in Midlands Province, Zimbabwe, reported the lowest rate of immunisation coverage in the country in 2005: 55 per cent of children vaccinated with three doses of diphtheria/pertussis/tetanus vaccine (DPT3) and 35 per cent dropout between the first and third dose of DPT. In January 2007, the authors assessed local barriers to immunisation and proposed strategies to improve immunisation rates in the district, in the face of nationwide economic and political challenges. A situational analysis was performed to assess barriers to immunisation using focus-group discussions with health workers, key informant interviews with health management and community leaders, and desk reviews of records. Responses were categorised and solutions proposed. Health workers and key informants reported that immunisation service delivery was hampered by insufficient availability of gas for cold-chain equipment, limited transport and fuel to conduct basic activities, and inadequate staff and supervision. Improving coverage will require prioritising gas for vaccine cold-chain equipment, identifying reliable transportation or alternative transportation solutions, and increased staff, training and supervision. Local assessment is critical to pinpointing site-specific barriers, and innovative strategies are needed to overcome existing contextual challenges. C1 [Chadambuka, Addmore; Apollo, Tsitsilina; Tshimanga, Mufuta] Univ Zimbabwe, Dept Community Med, Harare, Zimbabwe. [Luman, Elizabeth T.] US Ctr Dis Control & Prevent, Ctr Global Hlth, Atlanta, GA USA. RP Chadambuka, A (reprint author), Hlth Studies Off, POB CY1122, Harare, Zimbabwe. EM achadambuka1@yahoo.co.uk OI Chadambuka, Addmore/0000-0003-2407-1172 NR 39 TC 3 Z9 3 U1 1 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0361-3666 J9 DISASTERS JI Disasters PD JAN PY 2012 VL 36 IS 1 BP 161 EP 173 DI 10.1111/j.1467-7717.2011.01246.x PG 13 WC Planning & Development SC Public Administration GA 857CY UT WOS:000297693700008 PM 21623892 ER PT J AU Jackson, ML Rose, CE Cohn, A Coronado, F Clark, TA Wenger, JD Bulkow, L Bruce, MG Messonnier, NE Hennessy, TW AF Jackson, Michael L. Rose, Charles E. Cohn, Amanda Coronado, Fatima Clark, Thomas A. Wenger, Jay D. Bulkow, Lisa Bruce, Michael G. Messonnier, Nancy E. Hennessy, Thomas W. TI Modeling Insights into Haemophilus influenzae Type b Disease, Transmission, and Vaccine Programs SO EMERGING INFECTIOUS DISEASES LA English DT Article ID HIB CONJUGATE VACCINE; UNITED-KINGDOM; CHILDREN; POPULATION; IMPACT; IMMUNIZATION; CARRIAGE; ALASKA AB In response to the 2007-2009 Haemophilus influenzae type b (Hib) vaccine shortage in the United States, we developed a flexible model of Hib transmission and disease for optimizing Hib vaccine programs in diverse populations and situations. The model classifies population members by age, colonization/disease status, and antibody levels, with movement across categories defined by differential equations. We implemented the model for the United States as a whole, England and Wales, and the Alaska Native population. This model accurately simulated Hib incidence in all 3 populations, including the increased incidence in England/Wales beginning in 1999 and the change in Hib incidence in Alaska Natives after switching Hib vaccines in 1996. The model suggests that a vaccine shortage requiring deferral of the booster dose could last 3 years in the United States before loss of herd immunity would result in increasing rates of invasive Hib disease in children <5 years of age. C1 [Jackson, Michael L.; Rose, Charles E.; Cohn, Amanda; Coronado, Fatima; Clark, Thomas A.; Wenger, Jay D.; Bulkow, Lisa; Bruce, Michael G.; Messonnier, Nancy E.; Hennessy, Thomas W.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Jackson, ML (reprint author), Grp Hlth Res Inst, 1730 Minor Ave,Ste 1600, Seattle, WA 98101 USA. EM jackson.ml@ghc.org NR 30 TC 6 Z9 7 U1 0 U2 2 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JAN PY 2012 VL 18 IS 1 BP 13 EP 20 DI 10.3201/eid1801.110336 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 874QK UT WOS:000298973000003 PM 22257582 ER PT J AU Isaac-Renton, JL Chang, Y Prystajecky, N Petric, M Mak, A Abbott, B Paris, B Decker, KC Pittenger, L Guercio, S Stott, J Miller, JD AF Isaac-Renton, Judith L. Chang, Yin Prystajecky, Natalie Petric, Martin Mak, Annie Abbott, Brendan Paris, Benjamin Decker, K. C. Pittenger, Lauren Guercio, Steven Stott, Jeff Miller, Joseph D. TI Use of Lean Response to Improve Pandemic Influenza Surge in Public Health Laboratories SO EMERGING INFECTIOUS DISEASES LA English DT Article ID TOYOTA PRODUCTION SYSTEM; PRINCIPLES AB A novel influenza A (H1N1) virus detected in April 2009 rapidly spread around the world. North American provincial and state laboratories have well-defined roles and responsibilities, including providing accurate, timely test results for patients and information for regional public health and other decision makers. We used the multidisciplinary response and rapid implementation of process changes based on Lean methods at the provincial public health laboratory in British Columbia, Canada, to improve laboratory surge capacity in the 2009 influenza pandemic. Observed and computer simulating evaluation results from rapid processes changes showed that use of Lean tools successfully expanded surge capacity, which enabled response to the 10-fold increase in testing demands. C1 [Isaac-Renton, Judith L.] Prov Hlth Serv Author, Publ Hlth Microbiol & Reference Lab, Vancouver, BC V5Z 4R4, Canada. [Isaac-Renton, Judith L.; Prystajecky, Natalie; Petric, Martin] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada. [Paris, Benjamin; Decker, K. C.; Pittenger, Lauren] Booz Allen Hamilton, Mclean, VA USA. [Guercio, Steven] Publ Hlth Agcy Canada, Winnipeg, MB, Canada. [Miller, Joseph D.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Isaac-Renton, JL (reprint author), Prov Hlth Serv Author, Publ Hlth Microbiol & Reference Lab, 655 W 12th Ave, Vancouver, BC V5Z 4R4, Canada. EM judy.isaac-renton@bccdc.ca FU Provincial Health Services Authority; Canadian Public Health Laboratory Network Secretariat FX We thank all PHMRL staff who made this successful pandemic response possible. We also appreciate the timely support provided by Provincial Health Services Authority and the support of public health and clinical leaders who worked on the pandemic response across Canada.; The modeling work and ongoing support are provided by the Canadian Public Health Laboratory Network Secretariat. NR 16 TC 5 Z9 5 U1 0 U2 8 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JAN PY 2012 VL 18 IS 1 BP 57 EP 62 DI 10.3201/eid1801.101485 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 874QK UT WOS:000298973000008 PM 22257385 ER PT J AU Filozov, A Kattan, JA Jitendranath, L Smith, CG Luquez, C Phan, QN Fagan, RP AF Filozov, Alina Kattan, Jessica A. Jitendranath, Lavanya Smith, C. Gregory Luquez, Carolina Phan, Quyen N. Fagan, Ryan P. TI Asymmetric Type F Botulism with Cranial Nerve Demyelination SO EMERGING INFECTIOUS DISEASES LA English DT Article ID UNITED-STATES AB We report a case of type F botulism in a patient with bilateral but asymmetric neurologic deficits. Cranial nerve demyelination was found during autopsy. Bilateral, asymmetric clinical signs, although rare, do not rule out botulism. Demyelination of cranial nerves might be underrecognized during autopsy of botulism patients. C1 [Filozov, Alina] Middlesex Hosp, Div Infect Dis, Middletown, CT 06457 USA. [Kattan, Jessica A.; Luquez, Carolina; Fagan, Ryan P.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Kattan, Jessica A.; Phan, Quyen N.] Connecticut Dept Publ Hlth, Hartford, CT USA. [Smith, C. Gregory] N Carolina Dept Hlth & Human Serv, Raleigh, NC USA. RP Filozov, A (reprint author), Middlesex Hosp, Div Infect Dis, 80 S Main St, Middletown, CT 06457 USA. EM alina.filozov@midhosp.org FU CDC, Coordinating Office for Terrorism Preparedness and Emergency Response FX This study was supported by funds made available from CDC, Coordinating Office for Terrorism Preparedness and Emergency Response. NR 11 TC 3 Z9 3 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JAN PY 2012 VL 18 IS 1 BP 102 EP 104 DI 10.3201/eid1801.110471 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 874QK UT WOS:000298973000017 PM 22257488 ER PT J AU David, MZ Rudolph, KM Hennessy, TW Zychowski, DL Asthi, K Boyle-Vavra, S Daum, RS AF David, Michael Z. Rudolph, Karen M. Hennessy, Thomas W. Zychowski, Diana L. Asthi, Karthik Boyle-Vavra, Susan Daum, Robert S. TI MRSA USA300 at Alaska Native Medical Center, Anchorage, Alaska, USA, 2000-2006 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID RESISTANT STAPHYLOCOCCUS-AUREUS; METHICILLIN-RESISTANT; EMERGENCY-DEPARTMENT; INFECTIONS; SKIN AB To determine whether methicillin-resistant Staphylococcus aureus (MRSA) USA300 commonly caused infections among Alaska Natives, we examined clinical MRSA isolates from the Alaska Native Medical Center, Anchorage, during 2000-2006. Among Anchorage-region residents, USA300 was a minor constituent among MRSA isolates in 2000-2003 (11/68, 16%); by 2006, USA300 was the exclusive genotype identified (10/10). C1 [David, Michael Z.] Univ Chicago, Dept Med, Chicago, IL 60637 USA. [David, Michael Z.] Univ Chicago, Dept Pediat, Chicago, IL 60637 USA. [David, Michael Z.] Univ Chicago, Dept Hlth Studies, Chicago, IL 60637 USA. [Rudolph, Karen M.; Hennessy, Thomas W.] Ctr Dis Control & Prevent, Anchorage, AK USA. RP David, MZ (reprint author), Univ Chicago, Dept Med, 5841 S Maryland Ave,MC6054, Chicago, IL 60637 USA. EM mdavid@medicine.bsd.uchicago.edu FU Centers for Disease Control and Prevention [R01 CCR523379, R01 C1000373-01]; National Insititutes of Health [R01 A140481-0A1, 2R56AI040481-08A1, 1 U01 GM087729-01/B270JA]; Grant Healthcare Foundation; Lawrence Livermore Laboratory FX R.S.D. and S.B.-V. are supported by grants from the Centers for Disease Control and Prevention (R01 CCR523379 and R01 C1000373-01), National Insititutes of Health (R01 A140481-0A1 and 2R56AI040481-08A1), and the Grant Healthcare Foundation. S.B-V. is supported by the Lawrence Livermore Laboratory. M.Z.D. is supported by grant R01 C1000373-01 (CDC); M.Z.D. and R.S.D. are supported by grant 1 U01 GM087729-01/B270JA (NIH). The Institutional Review Boards of the University of Chicago, Centers for Disease Control and Prevention, and Alaska Area Indian Health Service, and the boards of directors of the Alaska Native Tribal Health Consortium and the Southcentral Foundation approved the study. NR 15 TC 4 Z9 4 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JAN PY 2012 VL 18 IS 1 BP 105 EP 108 DI 10.3201/eid1801.110746 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 874QK UT WOS:000298973000018 PM 22264651 ER PT J AU Barry, PM Gardner, TJ Funk, E Oren, E Field, K Shaw, T Langer, AJ AF Barry, Pennan M. Gardner, Tracie J. Funk, Elizabeth Oren, Eyal Field, Kimberly Shaw, Tambi Langer, Adam J. TI Multistate Outbreak of MDR TB Identified by Genotype Cluster Investigation SO EMERGING INFECTIOUS DISEASES LA English DT Article ID MYCOBACTERIUM-TUBERCULOSIS AB In 2008, diagnosis and investigation of 2 multidrug-resistant tuberculosis cases with matching genotypes led to identification of an outbreak among foreign-born persons who performed short-term seafood production work in Alaska during 2006. Tuberculosis control programs should consider the possibility of domestic transmission even among foreign-born patients. C1 [Barry, Pennan M.] Calif Dept Publ Hlth, TB Control Branch, Surveillance & Epidemiol Sect, Richmond, CA 94804 USA. [Gardner, Tracie J.; Funk, Elizabeth] Alaska Div Publ Hlth, Anchorage, AK USA. [Gardner, Tracie J.; Langer, Adam J.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Oren, Eyal] Publ Hlth Seattle & King Cty, Seattle, WA USA. [Field, Kimberly] Washington State Dept Hlth, Olympia, WA USA. RP Barry, PM (reprint author), Calif Dept Publ Hlth, TB Control Branch, Surveillance & Epidemiol Sect, 850 Marina Bay Pkwy,Bldg P,2nd Fl, Richmond, CA 94804 USA. EM pennan.barry@cdph.ca.gov OI Oren, Eyal/0000-0001-7817-3516 FU Centers for Disease Control and Prevention FX Funding for genotyping was provided to the California Department of Public Health by a Centers for Disease Control and Prevention contract. NR 10 TC 12 Z9 13 U1 1 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JAN PY 2012 VL 18 IS 1 BP 113 EP 116 DI 10.3201/eid1801.110671 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 874QK UT WOS:000298973000020 PM 22260877 ER PT J AU Radke, EG Gregory, CJ Kintziger, KW Sauber-Schatz, EK Hunsperger, EA Gallagher, GR Barber, JM Biggerstaff, BJ Stanek, DR Tomashek, KM Blackmore, CGM AF Radke, Elizabeth G. Gregory, Christopher J. Kintziger, Kristina W. Sauber-Schatz, Erin K. Hunsperger, Elizabeth A. Gallagher, Glen R. Barber, Jean M. Biggerstaff, Brad J. Stanek, Danielle R. Tomashek, Kay M. Blackmore, Carina G. M. TI Dengue Outbreak in Key West, Florida, USA, 2009 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID HEMORRHAGIC-FEVER; DIAGNOSIS; VIRUS AB After 3 dengue cases were acquired in Key West, Florida, we conducted a serosurvey to determine the scope of the outbreak. Thirteen residents showed recent infection (infection rate 5%; 90% Cl 2%-8%), demonstrating the reemergence of dengue in Florida. Increased awareness of dengue among health care providers is needed. C1 [Radke, Elizabeth G.; Kintziger, Kristina W.; Sauber-Schatz, Erin K.; Stanek, Danielle R.; Blackmore, Carina G. M.] Florida Dept Hlth, Tallahassee, FL USA. [Gregory, Christopher J.; Hunsperger, Elizabeth A.; Gallagher, Glen R.; Tomashek, Kay M.] Ctr Dis Control & Prevent, San Juan, PR USA. [Sauber-Schatz, Erin K.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Barber, Jean M.] Monroe Cty Hlth Dept, Key West, FL USA. [Biggerstaff, Brad J.] Ctr Dis Control & Prevent, Ft Collins, CO USA. RP Blackmore, CGM (reprint author), 4052 Bald Cypress Way,Bin A-08, Tallahassee, FL 32339 USA. EM carina_blackmore@doh.state.fl.us FU CDC through an Epidemiology and Laboratory Capacity FX Financial support for this project was provided by the CDC through an Epidemiology and Laboratory Capacity grant. NR 15 TC 55 Z9 56 U1 1 U2 12 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JAN PY 2012 VL 18 IS 1 BP 135 EP 137 DI 10.3201/eid1801.110130 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 874QK UT WOS:000298973000026 PM 22257471 ER PT J AU Petersen, BW Tack, DM Longenberger, A Simeone, A Moll, ME Deasy, MP Blanton, JD Rupprecht, CE AF Petersen, Brett W. Tack, Danielle M. Longenberger, Allison Simeone, Aliza Moll, Maria E. Deasy, Marshall P. Blanton, Jesse D. Rupprecht, Charles E. TI Rabies in Captive Deer, Pennsylvania, USA, 2007-2010 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID UNITED-STATES; POSTEXPOSURE PROPHYLAXIS; IMMUNIZATION PRACTICES; ADVISORY-COMMITTEE; RECOMMENDATIONS AB Since January 2007, a total of 11 rabid deer from 4 deer farms have been identified in 2 neighboring Pennsylvania counties. Vaccination of deer against rabies, decreasing wildlife animal contact with deer, and education of deer farmers may prevent further cases of rabies in captive deer and exposures to humans. C1 [Petersen, Brett W.; Tack, Danielle M.; Longenberger, Allison; Blanton, Jesse D.; Rupprecht, Charles E.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Simeone, Aliza] Penn Dept Agr, Harrisburg, PA USA. [Moll, Maria E.; Deasy, Marshall P.] Penn Dept Hlth, Harrisburg, PA 17108 USA. RP Petersen, BW (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop G06, Atlanta, GA 30333 USA. EM bpetersen@cdc.gov NR 6 TC 5 Z9 5 U1 1 U2 4 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JAN PY 2012 VL 18 IS 1 BP 138 EP 141 DI 10.3201/eid1801.111189 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 874QK UT WOS:000298973000027 PM 22260956 ER PT J AU Azziz-Baumgartner, E Rahman, M Al Mamun, A Haider, MS Zaman, RU Karmakar, PC Nasreen, S Mah-E-Muneer, S Homaira, N Goswami, DR Ahmed, BN Husain, MM Jamil, KM Khatun, S Ahmed, M Chakraborty, A Fry, A Widdowson, MA Bresee, J Azim, T Alamgir, ASM Brooks, A Hossain, MJ Klimov, A Rahman, M Luby, SP AF Azziz-Baumgartner, Eduardo Rahman, Mustafizur Al Mamun, Abdullah Haider, Mohammad Sabbir Zaman, Rashid Uz Karmakar, Polash Chandra Nasreen, Sharifa Mah-E-Muneer, Syeda Homaira, Nusrat Goswami, Doli Rani Ahmed, Be-Nazir Husain, Mohammad Mushtuq Jamil, Khondokar Mahbuba Khatun, Selina Ahmed, Mujaddeed Chakraborty, Apurba Fry, Alicia Widdowson, Marc-Alain Bresee, Joseph Azim, Tasnim Alamgir, A. S. M. Brooks, Abdullah Hossain, Mohamed Jahangir Klimov, Alexander Rahman, Mahmudur Luby, Stephen P. TI Early Detection of Pandemic (H1N1) 2009, Bangladesh SO EMERGING INFECTIOUS DISEASES LA English DT Article ID RURAL BANGLADESH; SURVEILLANCE AB To explore Bangladesh's ability to detect novel influenza, we examined a series of laboratory-confirmed pandemic (H1N1) 2009 cases. During June-July 2009, event-based surveillance identified 30 case-patients (57% travelers); starting July 29, sentinel sites identified 252 case-patients (1% travelers). Surveillance facilitated response weeks before the spread of pandemic (H1N1) 2009 infection to the general population. C1 [Azziz-Baumgartner, Eduardo; Fry, Alicia; Widdowson, Marc-Alain; Bresee, Joseph; Klimov, Alexander; Luby, Stephen P.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Azziz-Baumgartner, Eduardo; Rahman, Mustafizur; Al Mamun, Abdullah; Zaman, Rashid Uz; Karmakar, Polash Chandra; Nasreen, Sharifa; Mah-E-Muneer, Syeda; Homaira, Nusrat; Goswami, Doli Rani; Chakraborty, Apurba; Azim, Tasnim; Brooks, Abdullah; Hossain, Mohamed Jahangir; Luby, Stephen P.] Int Ctr Diarrhoeal Dis Res, Dhaka 1000, Bangladesh. [Haider, Mohammad Sabbir; Ahmed, Be-Nazir; Husain, Mohammad Mushtuq; Jamil, Khondokar Mahbuba; Chakraborty, Apurba; Alamgir, A. S. M.; Rahman, Mahmudur] Inst Epidemiol Dis Control & Res, Dhaka, Bangladesh. [Khatun, Selina; Ahmed, Mujaddeed] World Hlth Org, Dhaka, Bangladesh. RP Azziz-Baumgartner, E (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop A32, Atlanta, GA 30333 USA. EM eha9@cdc.gov RI rahman, mustafizur/E-6918-2010; OI Widdowson, Marc-Alain/0000-0002-0682-6933 FU Centers for Disease Control and Prevention [U01/CI000628-02] FX This study was supported by the Centers for Disease Control and Prevention, grant no. U01/CI000628-02. NR 14 TC 4 Z9 4 U1 0 U2 2 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JAN PY 2012 VL 18 IS 1 BP 146 EP 149 DI 10.3201/eid1801.101996 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 874QK UT WOS:000298973000029 PM 22257637 ER PT J AU Chisholm, K Dueger, E Fahmy, NT Samaha, HAT Zayed, A Abdel-Dayem, M Villinski, JT AF Chisholm, Katherine Dueger, Erica Fahmy, Nermeen T. Samaha, Hamed Abdel Tawab Zayed, Alia Abdel-Dayem, Mahmoud Villinski, Jeffrey T. TI Crimean-Congo Hemorrhagic Fever Virus in Ticks from Imported Livestock, Egypt SO EMERGING INFECTIOUS DISEASES LA English DT Letter C1 [Chisholm, Katherine; Dueger, Erica; Fahmy, Nermeen T.; Zayed, Alia; Abdel-Dayem, Mahmoud; Villinski, Jeffrey T.] US Naval Med Res Unit 3, Cairo, Egypt. [Dueger, Erica] Ctr Dis Control & Prevent, Atlanta, GA USA. [Samaha, Hamed Abdel Tawab] Minist Agr, Cairo, Egypt. RP Villinski, JT (reprint author), USN, Vector Biol Res Program, Med Res Unit, 3,PSC 452 Box 5000, Fpo, AE 09835 USA. EM jeff.villinski@med.navy.mil RI Valle, Ruben/A-7512-2013; OI Abdel-Dayem, Mahmoud/0000-0002-6276-1740 NR 7 TC 6 Z9 8 U1 1 U2 5 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JAN PY 2012 VL 18 IS 1 BP 181 EP 182 DI 10.3201/eid1801.111071 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 874QK UT WOS:000298973000044 PM 22260737 ER PT J AU Potter, P AF Potter, Polyxeni TI Tough Art and Microbial Drama SO EMERGING INFECTIOUS DISEASES LA English DT Editorial Material C1 Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Potter, P (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop D61, Atlanta, GA 30333 USA. EM pmp1@cdc.gov NR 11 TC 0 Z9 0 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JAN PY 2012 VL 18 IS 1 BP 196 EP 197 DI 10.3201/eid1801.AC1801 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 874QK UT WOS:000298973000052 PM 22371961 ER PT J AU Maenner, MJ Benedict, RE Arneson, CL Yeargin-Allsopp, M Wingate, MS Kirby, RS Braun, KVN Durkin, MS AF Maenner, Matthew J. Benedict, Ruth E. Arneson, Carrie L. Yeargin-Allsopp, Marshalyn Wingate, Martha S. Kirby, Russell S. Braun, Kim Van Naarden Durkin, Maureen S. TI Children With Cerebral Palsy Racial Disparities in Functional Limitations SO EPIDEMIOLOGY LA English DT Article ID GROSS MOTOR FUNCTION; UNITED-STATES; PREVALENCE; CLASSIFICATION; EPIDEMIOLOGY; RELIABILITY; TRENDS; SEVERITY; SUBTYPE; NETWORK AB Background: Previous studies of the frequency of cerebral palsy in the United States have found excess prevalence in black children relative to other groups. Whether the severity of cerebral palsy differs between black and white children has not previously been investigated. Methods: A population-based surveillance system in 4 regions of the United States identified 476 children with cerebral palsy among 142,338 8-year-old children in 2006. Motor function was rated by the Gross Motor Function Classification System and grouped into 3 categories of severity. We used multiple imputation to account for missing information on motor function and calculated the race-specific prevalence of each cerebral palsy severity level. Results: The prevalence of cerebral palsy was 3.7 per 1000 black children and 3.2 per 1000 white children (prevalence odds ratio [OR] = 1.2 [95% confidence interval = 1.0-1.4]). When stratified by severity of functional limitation, the racial disparity was present only for severe cerebral palsy (black vs. white prevalence OR = 1.7 [1.1-2.4]). The excess prevalence of severe cerebral palsy in black children was evident in term and very preterm birth strata. Conclusion: Black children in the United States appear to have a higher prevalence of cerebral palsy overall than white children, although the excess prevalence of cerebral palsy in black children is seen only among those with the most severe limitations. Further research is needed to explore reasons for this disparity in functional limitations; potential mechanisms include racial differences in risk factors, access to interventions, and under-identification of mild cerebral palsy in black children. C1 [Maenner, Matthew J.; Benedict, Ruth E.; Arneson, Carrie L.; Durkin, Maureen S.] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA. [Maenner, Matthew J.; Durkin, Maureen S.] Univ Wisconsin, Dept Populat Hlth Sci, Sch Med & Publ Hlth, Madison, WI 53705 USA. [Benedict, Ruth E.] Univ Wisconsin, Dept Kinesiol, Org Therapy Program, Madison, WI 53705 USA. [Yeargin-Allsopp, Marshalyn; Braun, Kim Van Naarden] Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Wingate, Martha S.] Univ Alabama Birmingham, Sch Publ Hlth, Dept Hlth Care Org & Policy, Birmingham, AL 35294 USA. [Kirby, Russell S.] Univ S Florida, Coll Publ Hlth, Dept Community & Family Med, Tampa, FL USA. [Durkin, Maureen S.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Pediat, Madison, WI 53705 USA. RP Maenner, MJ (reprint author), Univ Wisconsin, Waisman Ctr, 1500 Highland Ave,Rm 529A, Madison, WI 53705 USA. EM mjmaenner@wisc.edu RI Durkin, Maureen/B-7834-2015 FU Centers for Disease Control and Prevention [UR3/DD000677, UR3/DD000078]; University of Wisconsin-Madison FX Supported by the Centers for Disease Control and Prevention through Cooperative Agreements UR3/DD000677 and UR3/DD000078 as part of the Autism and Developmental Disabilities Monitoring Network. Additional funding for graduate student support for data analysis was provided by the University of Wisconsin-Madison. M.J.M. was partially supported by a grant from the Autism Science Foundation. The authors reported no other financial interests related to this research. NR 37 TC 5 Z9 5 U1 1 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD JAN PY 2012 VL 23 IS 1 BP 35 EP 43 DI 10.1097/EDE.0b013e31823a4205 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 863IU UT WOS:000298156800007 PM 22081059 ER PT J AU Hadgu, A Dendukuri, N Wang, LL AF Hadgu, Alula Dendukuri, Nandini Wang, Liangliang TI Evaluation of Screening Tests for Detecting Chlamydia trachomatis Bias Associated With the Patient-infected-status Algorithm SO EPIDEMIOLOGY LA English DT Article ID ACID AMPLIFICATION TESTS; DIAGNOSTIC-TESTS; DISCREPANT ANALYSIS; NEISSERIA-GONORRHOEAE; GOLD-STANDARD; CONDITIONAL DEPENDENCE; ISSUES; PERFORMANCE; SPECIMENS; ACCURACY AB In recent years, the evaluation of nucleic acid amplification tests (NAATs) for detecting Chlamydia trachomatis and Neisseria gonorrhea is based on a methodology called the patient-infected-status algorithm (PISA). In the simplest version of PISA, 4 test-specimen combinations (comparator tests) are used to define the gold standard. If a person shows a positive result by any 2 or more of these 4 comparator tests, the person is classified as infected; otherwise, the person is considered to be uninfected. A new test is then compared with this diagnostic algorithm. PISA-based sensitivity and specificity estimates of nucleic acid amplification tests have been published in the medical and microbiologic literature and have been included in FDA-approved package inserts of NAATs for detecting C. trachomatis. Using simulations, we compare 2 versions of the patient-infected-status algorithm with latent-class models and an imperfect gold standard. We show that the PISA can produce highly biased test-performance parameter estimates. In a series of simulated scenarios, none of the 95% confidence intervals for PISA-based estimates of sensitivity and prevalence contained the true values. In addition, the PISA-based estimates of sensitivity and specificity change markedly as the true prevalence changes. We recommend that PISA should not be used for estimating the sensitivity and specificity of tests. C1 [Hadgu, Alula] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA USA. [Dendukuri, Nandini] McGill Univ, Ctr Hlth, Technol Assessment Unit, Montreal, PQ, Canada. [Dendukuri, Nandini] McGill Univ, Dept Epidemiol & Biostat, Montreal, PQ, Canada. [Wang, Liangliang] Univ British Columbia, Dept Stat, Vancouver, BC V6T 1W5, Canada. RP Hadgu, A (reprint author), Ctr Dis Control, Div STD Prevent, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM AHadgu@cdc.gov FU Fonds de la Recherche en Sante' du Quebec FX Supported by a Chercheur Boursier Junior 2 award from the Fonds de la Recherche en Sante' du Quebec. The authors reported no other financial interests related to this research. NR 35 TC 9 Z9 9 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD JAN PY 2012 VL 23 IS 1 BP 72 EP 82 DI 10.1097/EDE.0b013e31823b506b PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 863IU UT WOS:000298156800012 PM 22157304 ER PT J AU Murray, EL Klein, M Brondi, L McGowan, JE Van Mels, C Brooks, WA Kleinbaum, D Goswami, D Ryan, PB Bridges, CB AF Murray, E. L. Klein, M. Brondi, L. McGowan, J. E., Jr. Van Mels, C. Brooks, W. A. Kleinbaum, D. Goswami, D. Ryan, P. B. Bridges, C. B. TI Rainfall, household crowding, and acute respiratory infections in the tropics SO EPIDEMIOLOGY AND INFECTION LA English DT Article DE Climate; influenza; paediatrics; respiratory infection ID MEDICAL-CARE GROUP; PRESCHOOL-CHILDREN; TRACT INFECTIONS; INFLUENZA-A; EPIDEMIOLOGY; TRANSMISSION; ETIOLOGY; VIRUS; BANGLADESH; PNEUMONIA AB Acute respiratory infections (ARI) are the leading cause of death worldwide in children aged <5 years, and understanding contributing factors to their seasonality is important for targeting and implementing prevention strategies. In tropical climates, ARI typically peak during the pre-rainy and rainy seasons. One hypothesis is that rainfall leads to more time spent indoors, thus increasing exposure to other people and in turn increasing the risk of ARI. A case-crossover study design in 718 Bangladeshi children aged <5 years was used to evaluate this hypothesis. During a 3-month period with variable rainfall, rainfall was associated with ARI [odds ratio (OR) 2.97, 95% confidence interval (CI) 1.87-4.70]; some evidence of an increased strength of association as household crowding increased was found (>= 3 people/room, OR 3.31, 95% CI 2.03-5.38), but there was a lack of association in some of the most crowded households (>= 5 to < 6 people/room, OR 1.55, 95% CI 0.54-4.47). These findings suggest that rainfall may be increasing exposure to crowded conditions, thus leading to an increased risk of ARI, but that additional factors not captured by this analysis may also play a role. C1 [Murray, E. L.; Klein, M.; McGowan, J. E., Jr.; Kleinbaum, D.] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA. [Brondi, L.; Van Mels, C.; Brooks, W. A.; Goswami, D.] Int Ctr Diarrhoeal Dis Res, Dhaka 1000, Bangladesh. [Ryan, P. B.] Emory Univ, Dept Environm & Occupat Hlth, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Bridges, C. B.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Murray, EL (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv, Calif Dept Publ Hlth, STD Control Branch, 850 Marina Bay Pkwy,Bldg P,2nd Floor, Richmond, CA 94804 USA. EM emurray24@gmail.com RI mcgowan jr, john/G-5404-2011 FU National Vaccine Program Office, US Department of Health and Human Services; Achievement Rewards for College Scientists; Emory University Graduate School of Arts and Sciences; Anoopa Sharma Awards FX We thank the staff at the Kamalapur field site and at ICDDR,B for their hard work collecting and entering the data used in this study. This study was supported by the National Vaccine Program Office, US Department of Health and Human Services, Achievement Rewards for College Scientists, Emory University Graduate School of Arts and Sciences Fund for Internationalization, Rollins School of Public Health Global Field Experience and Anoopa Sharma Awards. NR 35 TC 20 Z9 20 U1 0 U2 4 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD JAN PY 2012 VL 140 IS 1 BP 78 EP 86 DI 10.1017/S0950268811000252 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 868TC UT WOS:000298547400010 PM 21371367 ER PT J AU Dowell, SF AF Dowell, S. F. TI Seasonality - still confusing SO EPIDEMIOLOGY AND INFECTION LA English DT Editorial Material ID VITAMIN-D SUPPLEMENTATION; INFECTIOUS-DISEASES; INFLUENZA-A; TRANSMISSION; EPIDEMIOLOGY; PREVENTION; PATTERNS; CYCLES; CLOCK; TRIAL C1 Ctr Dis Control & Prevent, Div Global Dis Detect & Emergency Response, Ctr Global Hlth, Atlanta, GA 30333 USA. RP Dowell, SF (reprint author), Ctr Dis Control & Prevent, Div Global Dis Detect & Emergency Response, Ctr Global Hlth, 1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM sdowell@cdc.gov NR 25 TC 5 Z9 5 U1 0 U2 5 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD JAN PY 2012 VL 140 IS 1 BP 87 EP 90 DI 10.1017/S0950268811001695 PG 4 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 868TC UT WOS:000298547400011 PM 21906417 ER PT J AU Parker, VG Coles, CJ Black, VW AF Parker, Veronica G. Coles, Charlton J. Black, Valerie W. TI Foreword SO FAMILY & COMMUNITY HEALTH LA English DT Editorial Material ID HEALTH INFORMATION; MEDIA C1 [Parker, Veronica G.] Clemson Univ, Sch Nursing, Clemson, SC 29634 USA. [Parker, Veronica G.] Clemson Univ, Ctr Res Hlth Dispar, Clemson, SC USA. [Coles, Charlton J.] Ctr Dis Control & Prevent, Agcy Tox Subst & Dis Registry, Div Toxicol & Environm Med, Atlanta, GA USA. [Black, Valerie W.] Johnson C Smith Univ, Charlotte, NC USA. RP Parker, VG (reprint author), Clemson Univ, Sch Nursing, Clemson, SC 29634 USA. EM veronic@clemson.edu; fzn3@cdc.gov; vwblack@jcsu.edu RI Parker, Veronica/I-5160-2013 OI Parker, Veronica/0000-0002-5217-4569 NR 6 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0160-6379 J9 FAM COMMUNITY HEALTH JI Fam. Community Health PD JAN-MAR PY 2012 VL 35 IS 1 BP 2 EP 4 DI 10.1097/FCH.0b013e3182385cb9 PG 3 WC Family Studies; Public, Environmental & Occupational Health SC Family Studies; Public, Environmental & Occupational Health GA 863GC UT WOS:000298149800002 ER PT J AU Maslia, ML Aral, MM Faye, RE Grayman, WM Suarez-Soto, RJ Sautner, JB Anderson, BA Bove, FJ Ruckart, PZ Moore, SM AF Maslia, Morris L. Aral, Mustafa M. Faye, Robert E. Grayman, Walter M. Suarez-Soto, Rene J. Sautner, Jason B. Anderson, Barbara A. Bove, Frank J. Ruckart, Perri Z. Moore, Susan M. TI Complexities in Hindcasting Models-When Should We Say Enough Is Enough SO GROUND WATER LA English DT Editorial Material ID REDUCTIVE DECHLORINATION; TETRACHLOROETHENE; EXPOSURE; WATER C1 [Maslia, Morris L.; Suarez-Soto, Rene J.; Sautner, Jason B.; Anderson, Barbara A.; Ruckart, Perri Z.; Moore, Susan M.] DHAC, ATSDR, Atlanta, GA USA. [Aral, Mustafa M.] Georgia Inst Technol, Sch Civil & Environm Engn, Multimedia Environm Simulat Lab, Atlanta, GA 30332 USA. [Faye, Robert E.] RE Faye & Associates Inc, Blairsville, GA USA. [Faye, Robert E.] Eastern Res Grp Inc, Lexington, MA USA. [Grayman, Walter M.] WM Grayman Consulting Engineer, Cincinnati, OH USA. [Bove, Frank J.] DHS, Agcy Tox Subst & Dis Registry, Atlanta, GA USA. RP Maslia, ML (reprint author), DHAC, ATSDR, 4770 Buford Highway,NE Mail Stop F-59, Atlanta, GA USA. EM mmaslia@cdc.gov; maral@ce.gatech.edu; refaye@windstream.net; grayman@fuse.net; rsuarezsoto@cdc.gov; jsautner@cdc.gov; baanderson@cdc.gov; fbove@cdc.gov; pruckart@cdc.gov; smoore1@cdc.gov NR 39 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0017-467X J9 GROUND WATER JI Ground Water PD JAN-FEB PY 2012 VL 50 IS 1 BP 10 EP 16 DI 10.1111/j.1745-6584.2011.00884.x PG 7 WC Geosciences, Multidisciplinary; Water Resources SC Geology; Water Resources GA 871JH UT WOS:000298733600005 PM 22150251 ER PT J AU Espelage, DL Basile, KC Hamburger, ME AF Espelage, Dorothy L. Basile, Kathleen C. Hamburger, Merle E. TI Bullying Perpetration and Subsequent Sexual Violence Perpetration Among Middle School Students SO JOURNAL OF ADOLESCENT HEALTH LA English DT Article ID ADOLESCENCE; AGGRESSION; HARASSMENT; PEER; HOMOPHOBIA; BEHAVIORS; SCALE AB Purpose: This study examines the association between bullying experiences and sexual violence (SV) perpetration among a sample of middle school students (n = 1391; males and females in grades 5-8) across five middle schools in a Midwestern state. Methods: We include waves 1 and 2 of a larger longitudinal study that aimed to track the overlap between bullying and SV victimization and/or perpetration across a 3-year period. Wave 1 data were collected in the spring of 2008, and wave 2 data were collected in the fall of 2008. Student participants completed a series of scales in a paper and pencil survey. After missing data imputation, a total sample of 1391 students was analyzed. Results: Using cutoff scores, 12% of males and 12% of females could be considered bully perpetrators. Thirty-two percent of the boys (22% of girls) reported making sexual comments to other students, 5% of boys (7% of girls) spread a sexual rumor, and 4% of boys (2% of girls) pulled at someone's clothing. Bullying perpetration and homophobic teasing were significant predictors of sexual harassment perpetration over time. Conclusions: Given the overlap among bullying, homophobic teasing perpetration, and SV perpetration, future studies should address the link among these forms of aggression so that prevention programs can be enhanced to address gender-based bullying and sexual harassment. (C) 2012 Society for Adolescent Health and Medicine. All rights reserved. C1 [Espelage, Dorothy L.] Univ Illinois, Dept Educ Psychol, Champaign, IL 61820 USA. [Basile, Kathleen C.; Hamburger, Merle E.] Ctr Dis Control & Prevent, Div Violence Prevent, Atlanta, GA USA. RP Espelage, DL (reprint author), Univ Illinois, Dept Educ Psychol, 226 Educ Bldg,1310 S 6th St, Champaign, IL 61820 USA. EM espelage@illinois.edu FU National Center for Injury Prevention and Control, Centers for Disease Control Prevention [1U01/CE001677] FX The research was supported by the National Center for Injury Prevention and Control, Centers for Disease Control & Prevention, CDC Cooperative Agreement (number 1U01/CE001677) to D.E. (PI). NR 26 TC 40 Z9 40 U1 0 U2 20 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD JAN PY 2012 VL 50 IS 1 BP 60 EP 65 DI 10.1016/j.jadohealth.2011.07.015 PG 6 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA 866HH UT WOS:000298370700009 PM 22188835 ER PT J AU Choo, A Gerke, J Sellers, V Syed, M AF Choo, Alex Gerke, Jacob Sellers, Victoria Syed, Maha TI Environmental Health Internship Essentials SO JOURNAL OF ENVIRONMENTAL HEALTH LA English DT Editorial Material C1 [Choo, Alex] Natl Ctr Environm Hlth, CDC, Summer Program Environm Hlth, Environm Hlth Serv Branch,Div Emergency & Environ, Atlanta, GA 30341 USA. RP Choo, A (reprint author), Natl Ctr Environm Hlth, CDC, Summer Program Environm Hlth, Environm Hlth Serv Branch,Div Emergency & Environ, 4770 Buford Highway,NE MS F-60, Atlanta, GA 30341 USA. EM ehsb@cdc.gov NR 1 TC 0 Z9 0 U1 0 U2 0 PU NATL ENVIRON HEALTH ASSOC PI DENVER PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA SN 0022-0892 J9 J ENVIRON HEALTH JI J. Environ. Health PD JAN-FEB PY 2012 VL 74 IS 6 BP 52 EP 53 PG 2 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 874QC UT WOS:000298972200008 PM 22329209 ER PT J AU Kirman, CR Aylward, LL Blount, BC Pyatt, DW Hays, SM AF Kirman, Christopher R. Aylward, Lesa L. Blount, Ben C. Pyatt, David W. Hays, Sean M. TI Evaluation of NHANES biomonitoring data for volatile organic chemicals in blood: Application of chemical-specific screening criteria SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY LA English DT Article DE volatile organic compounds; VOCs; risk assessment; biomonitoring; biomonitoring equivalents ID EQUIVALENTS EXPERT WORKSHOP; GUIDELINES; EXPOSURE; SMOKING AB Available biomonitoring data for volatile organic chemicals (VOCs) in blood from the National Health and Nutrition Examination Survey (NHANES) (2003-2004) (CDC, 2009) were compared with recently derived screening biomonitoring equivalent (BE) values (Aylward et al., 2010). A BE is defined as the estimated concentration or range of concentrations of a chemical or its metabolites in a biological medium (blood, urine, or other medium) that is consistent with an existing health-based exposure guidance value. Blood concentrations of VOCs from the NHANES data set were compared with predicted screening BE values based upon a hazard quotient (HQ) for individual chemicals, and a hazard index (HI) approach for combined exposures. HI values for detected chemicals were generally at or below a value of 1, suggesting that the potential for deleterious effects is low. However, smoking was an important determinant of HI and HQ values. Detected levels of benzene in non-smokers were within the range of BE values corresponding to a 1 x 10(-6)-1 x 10(-4) range for upper-bound cancer risk; in smokers, levels of benzene were at the upper end of or exceeded this range. For VOCs that were not detected in the NHANES sampling, analytical detection limits were generally sufficiently sensitive to detect concentrations consistent with existing non-cancer and cancer risk-based exposure guidance values. Interpretations of measured blood concentrations of VOCs must be made with caution due to the substantial within-individual, within-day fluctuations in levels expected due to the rapid elimination of VOCs. Journal of Exposure Science and Environmental Epidemiology (2012) 22, 24-34; doi: 10.1038/jes.2011.37; published online 12 October 2011 C1 [Kirman, Christopher R.] Summit Toxicol, Orange Village, OH 44022 USA. [Aylward, Lesa L.] Summit Toxicol, Falls Church, VA USA. [Blount, Ben C.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Pyatt, David W.] Summit Toxicol, Superior, CO USA. [Hays, Sean M.] Summit Toxicol, Lyons, CO USA. RP Kirman, CR (reprint author), Summit Toxicol, 29449 Pike Dr, Orange Village, OH 44022 USA. EM ckirman@summittoxicology.com RI Aylward, Lesa/F-7418-2012 OI Aylward, Lesa/0000-0003-3191-8175 FU American Chemistry Council (ACC); American Petroleum Institute (API) FX Authors LLA, CRK, DWP, and SMH received funding from the American Chemistry Council (ACC) and the American Petroleum Institute (API) to support preparation of the manuscript. The authors had complete freedom to design, implement, and report the analyses presented herein. Author BCB declares no conflict of interest. NR 23 TC 7 Z9 7 U1 0 U2 6 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1559-0631 J9 J EXPO SCI ENV EPID JI J. Expo. Sci. Environ. Epidemiol. PD JAN-FEB PY 2012 VL 22 IS 1 BP 24 EP 34 DI 10.1038/jes.2011.37 PG 11 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 864NZ UT WOS:000298248200003 PM 21989501 ER PT J AU Rodriguez-Dozal, S Rodriguez, HR Hernandez-Avila, M Van Oostdam, J Weber, JP Needham, LL Trip, L AF Rodriguez-Dozal, Sandra Riojas Rodriguez, Horacio Hernandez-Avila, Mauricio Van Oostdam, Jay Weber, Jean Philippe Needham, Larry L. Trip, Luke TI Persistent organic pollutant concentrations in first birth mothers across Mexico SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY LA English DT Article DE PCBs; pesticides; dioxins and related compounds; biomonitoring ID POLYCHLORINATED-BIPHENYLS; DIOXIN-LIKE; PREGNANT-WOMEN; BREAST-CANCER; SERUM; EXPOSURE; HEALTH; CHIAPAS; PCBS; RISK AB This project was initiated by the North America Commission for Environmental Cooperation (CEC). Its main purpose was to obtain an initial profile on pregnant woman's exposure to persistent organic pollutants (POPs) in North America (Canada, the United States and Mexico). Persistent organic pollutants are transferred to the fetus via the placenta during the pregnancy or to the infant via maternal milk; therefore, the pregnant woman's body burden is important because of the higher exposures and potential health effects in the fetus and infant. This paper presents the results from 240 pregnant women in 10 Mexican cities, and includes the concentrations of various POPs such as polychlorinated biphenyls (PCBs), organochlorine pesticides and polychlorinated dibenzo dioxins and furans (PCDDs and PCDFs) in maternal plasma. We found concentrations of p, p'-DDE in maternal samples from Coatzacoalcos to be similar to 60% higher than those found in Ciudad Obregon, which had the second highest concentration. Pregnant women from Merida had higher mean concentrations of PCBs than all women in other regions. Results for PCDDs and PCDFs plus dioxin-like PCBs data were only available on the basis of composite samples, and their concentrations are similar in most cities except for Coatzacoalcos, which had more than double the concentration found in other cities. Although this study provides useful information on the variability of POPs in specific populations and possible regional/local differences, these results cannot be generalized to the entire Mexican population because of differences in age, gender, sources of exposure and nonrandom nature of the sample. Journal of Exposure Science and Environmental Epidemiology (2012) 22, 60-69; doi:10.1038/jes.2011.31;published online 5 October 2011 C1 [Rodriguez-Dozal, Sandra; Riojas Rodriguez, Horacio] Inst Nacl Salud Publ, Ctr Populat Heath Res, Dept Environm Hlth, Cuernavaca 62100, Morelos, Mexico. [Van Oostdam, Jay] Hlth Canada, Chem Surveillance Bur, Hlth Environm & Consumer Safety Branch, Ottawa, ON K1A 0L2, Canada. [Weber, Jean Philippe; Trip, Luke] Commiss Environm Cooperat, Montreal, PQ, Canada. [Needham, Larry L.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Rodriguez, HR (reprint author), Inst Nacl Salud Publ, Ctr Populat Heath Res, Dept Environm Hlth, Ave Univ 655, Cuernavaca 62100, Morelos, Mexico. EM hriojas@insp.mx FU Commission for Environmental Cooperation (Montreal, Canada); World Bank (Geneva, Switzerland) FX This study was supported by the Commission for Environmental Cooperation (Montreal, Canada) and by the World Bank (Geneva, Switzerland). We thank to the executive chiefs and staff from: Hospital de Especialidades del nino y la mujer Queretaro, Hospital General de Cuautitlan, Centro de Salud de la Cabecera Municipal de Tultitlan Centro, Hospital Materno Infantil Merida, Hospital General Coatzacoalcos, Hospital Universitario Monterrey, Hospital Integral Hermosillo, Hospital Zona "Yanga","Hospital General Ciudad Obregon, Hospital Civil Guadalajara and the mothers who participated in this study. NR 44 TC 4 Z9 4 U1 4 U2 13 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1559-0631 J9 J EXPO SCI ENV EPID JI J. Expo. Sci. Environ. Epidemiol. PD JAN-FEB PY 2012 VL 22 IS 1 BP 60 EP 69 DI 10.1038/jes.2011.31 PG 10 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 864NZ UT WOS:000298248200007 PM 21971379 ER PT J AU Nethery, E Wheeler, AJ Fisher, M Sjodin, A Li, Z Romanoff, LC Foster, W Arbuckle, TE AF Nethery, Elizabeth Wheeler, Amanda J. Fisher, Mandy Sjoedin, Andreas Li, Zheng Romanoff, Lovisa C. Foster, Warren Arbuckle, Tye E. TI Urinary polycyclic aromatic hydrocarbons as a biomarker of exposure to PAHs in air: A pilot study among pregnant women SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY LA English DT Article DE biomarkers; air pollution; polycyclic aromatic hydrocarbons; pregnancy; urinary metabolites ID ENVIRONMENTAL TOBACCO-SMOKE; PRENATAL EXPOSURE; DIETARY EXPOSURE; 1-HYDROXYPYRENE; ELIMINATION; POPULATION; AMBIENT; AREA AB Recent studies have linked increased polycyclic aromatic hydrocarbons (PAHs) in air and adverse fetal health outcomes. Urinary PAH metabolites are of interest for exposure assessment if they can predict PAHs in air. We investigated exposure to PAHs by collecting air and urine samples among pregnant women pre-selected as living in "high" (downtown and close to steel mills, n 9) and "low" (suburban, n 10) exposure areas. We analyzed firstmorning urine voids from all 3 trimesters of pregnancy for urinary PAH metabolites and compared these to personal air PAH/PM(2.5)/NO(2)/NOX samples collected in the 3rd trimester. We also evaluated activities and home characteristics, geographic indicators and outdoor central site PM(2.5)/NO(2)/NOX (all trimesters). Personal air exposures to the lighter molecular weight (MW) PAHs were linked to indoor sources (candles and incense), whereas the heavier PAHs were related to outdoor sources. Geometric means of all personal air measurements were higher in the "high" exposure group. We suggest that centrally monitored heavier MW PAHs could be used to predict personal exposures for heavier PAHs only. Urine metabolites were only directly correlated with their parent air PAHs for phenanthrene (Pearson's r = 0.31-0.45) and fluorene (r = 0.37-0.58). Predictive models suggest that specific metabolites (3-hydroyxyfluorene and 3-hydroxyphenanthrene) may be related to their parent air PAH exposures. The metabolite 2-hydroxynaphthalene was linked to smoking and the metabolite 1-hydroxypyrene was linked to dietary exposures. For researchers interested in predicting exposure to airborne lighter MW PAHs using urinary PAH metabolites, we propose that hydroxyfluorene and hydroxyphenanthrene metabolites be considered. Journal of Exposure Science and Environmental Epidemiology (2012) 22, 70-81; doi: 10.1038/jes.2011.32; published online 14 September 2011 C1 [Nethery, Elizabeth; Wheeler, Amanda J.] Hlth Canada, Air Hlth Sci Div, Ottawa, ON K1A 0K9, Canada. [Fisher, Mandy; Arbuckle, Tye E.] Hlth Canada, Populat Studies Div, Hlth Environm & Consumer Safety Branch, Ottawa, ON K1A 0L2, Canada. [Sjoedin, Andreas; Li, Zheng; Romanoff, Lovisa C.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Foster, Warren] McMaster Univ, Dept Obstet & Gynecol, Hamilton, ON, Canada. RP Wheeler, AJ (reprint author), Hlth Canada, Air Hlth Sci Div, 3rd Floor 4903C,269 Laurier Ave W, Ottawa, ON K1A 0K9, Canada. EM amanda.wheeler@hc-sc.gc.ca OI Wheeler, Amanda/0000-0001-9288-8163 FU Health Canada FX We acknowledge the study participants and their families, Elaine Moore for recruiting and running the field study, and Keith Van Ryswyk and Hongyu You for assistance with the air sampling. This work was funded by Health Canada. NR 30 TC 14 Z9 14 U1 2 U2 41 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1559-0631 J9 J EXPO SCI ENV EPID JI J. Expo. Sci. Environ. Epidemiol. PD JAN-FEB PY 2012 VL 22 IS 1 BP 70 EP 81 DI 10.1038/jes.2011.32 PG 12 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 864NZ UT WOS:000298248200008 PM 21915154 ER PT J AU Maharaj, PD Anishchenko, M Langevin, SA Fang, Y Reisen, WK Brault, AC AF Maharaj, Payal D. Anishchenko, Michael Langevin, Stanley A. Fang, Ying Reisen, William K. Brault, Aaron C. TI Structural gene (prME) chimeras of St Louis encephalitis virus and West Nile virus exhibit altered in vitro cytopathic and growth phenotypes SO JOURNAL OF GENERAL VIROLOGY LA English DT Article ID NONSTRUCTURAL PROTEIN NS1; TICK-BORNE ENCEPHALITIS; AMINO-ACID SUBSTITUTION; VECTOR COMPETENCE; AEDES-AEGYPTI; EQUINE ENCEPHALOMYELITIS; VIRAL DISSEMINATION; VACCINE CANDIDATE; CULEX MOSQUITOS; CAPSID PROTEIN AB Despite utilizing the same avian hosts and mosquito vectors, St Louis encephalitis virus (SLEV) and West Nile virus (WNV) display dissimilar vector-infectivity and vertebrate-pathogenic phenotypes. SLEV exhibits a low oral infection threshold for Culex mosquito vectors and is avirulent in avian hosts, producing low-magnitude viraemias. In contrast, WNV is less orally infective to mosquitoes and elicits high-magnitude viraemias in a wide range of avian species. In order to identify the genetic determinants of these different phenotypes and to assess the utility of mosquito and vertebrate cell lines for recapitulating in vivo differences observed between these viruses, reciprocal WNV and SLEV pre-membrane and envelope protein (prME) chimeric viruses were generated and growth of these mutant viruses was characterized in mammalian (Vero), avian (duck) and mosquito [Aedes (C6/36) and Culex (CT)] cells. In both vertebrate lines, WNV grew to 100-fold higher titres than SLEV, and growth and cytopathogenicity phenotypes, determined by chimeric phenotypes, were modulated by genetic elements outside the prME gene region. Both chimeras exhibited distinctive growth patterns from those of SLEV in C6/36 cells, indicating the role of both structural and non-structural gene regions for growth in this cell line. In contrast, growth of chimeric viruses was indistinguishable from that of virus containing homologous prME genes in CT cells, indicating that structural genetic elements could specifically dictate growth differences of these viruses in relevant vectors. These data provide genetic insight into divergent enzootic maintenance strategies that could also be useful for the assessment of emergence mechanisms of closely related flaviviruses. C1 [Maharaj, Payal D.; Anishchenko, Michael; Brault, Aaron C.] Ctr Dis Control & Prevent CDC, Div Vector Borne Dis, Ft Collins, CO 80521 USA. [Maharaj, Payal D.; Anishchenko, Michael; Langevin, Stanley A.; Fang, Ying; Reisen, William K.; Brault, Aaron C.] Univ Calif Davis, Sch Vet Med, Ctr Vector Borne Dis Res, Davis, CA 95616 USA. [Maharaj, Payal D.; Anishchenko, Michael; Langevin, Stanley A.; Fang, Ying; Reisen, William K.; Brault, Aaron C.] Univ Calif Davis, Sch Vet Med, Dept Pathol Microbiol & Immunol, Davis, CA 95616 USA. RP Brault, AC (reprint author), Ctr Dis Control & Prevent CDC, Div Vector Borne Dis, Ft Collins, CO 80521 USA. EM abrault@cdc.gov OI Maharaj, Payal/0000-0002-4157-4479 FU Pacific Southwest Regional Center for Excellence [AI065359]; NIH [AI061822, AI55607]; CDC [CI000235]; University of California FX Funding for these studies was provided by the Pacific Southwest Regional Center for Excellence (AI065359) and by grants from NIH (AI061822, AI55607), CDC (CI000235) and the University of California Mosquito Research Program. We would like to thank Jason Velez for providing cell-culture support for these studies. NR 51 TC 7 Z9 7 U1 0 U2 2 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 0022-1317 J9 J GEN VIROL JI J. Gen. Virol. PD JAN PY 2012 VL 93 BP 39 EP 49 DI 10.1099/vir.0.033159-0 PN 1 PG 11 WC Biotechnology & Applied Microbiology; Virology SC Biotechnology & Applied Microbiology; Virology GA 874QG UT WOS:000298972600004 PM 21940408 ER PT J AU Vandermeer, ML Thomas, AR Kamimoto, L Reingold, A Gershman, K Meek, J Farley, MM Ryan, P Lynfield, R Baumbach, J Schaffner, W Bennett, N Zansky, S AF Vandermeer, Meredith L. Thomas, Ann R. Kamimoto, Laurie Reingold, Arthur Gershman, Ken Meek, James Farley, Monica M. Ryan, Patricia Lynfield, Ruth Baumbach, Joan Schaffner, William Bennett, Nancy Zansky, Shelley TI Association Between Use of Statins and Mortality Among Patients Hospitalized With Laboratory-Confirmed Influenza Virus Infections: A Multistate Study SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID 1918 PANDEMIC VIRUS; CYTOKINE RESPONSES; A VIRUS; UNITED-STATES; H5N1; PATHOGENESIS; EXPRESSION; BENEFITS; THERAPY; DISEASE AB Background. Statins may have anti-inflammatory and immunomodulatory effects that could reduce the risk of mortality from influenza virus infections. Methods. The Centers for Disease Control and Prevention's Emerging Infections Program conducts active surveillance for persons hospitalized with laboratory-confirmed influenza in 59 counties in 10 states. We analyzed data for hospitalized adults during the 2007-2008 influenza season to evaluate the association between receiving statins and influenza-related death. Results. We identified 3043 patients hospitalized with laboratory-confirmed influenza, of whom 1013 (33.3%) received statins and 151 (5.0%) died within 30 days of their influenza test. Patients who received statins were more likely to be older, male, and white; to suffer from cardiovascular, metabolic, renal, and chronic lung disease; and to have been vaccinated against influenza that season. In a multivariable logistic regression model, administration of statins prior to or during hospitalization was associated with a protective odds of death (adjusted odds ratio, 0.59 [95% confidence interval, .38-.92]) when adjusting for age; race; cardiovascular, lung, and renal disease; influenza vaccination; and antiviral administration. Conclusions. Statin use may be associated with reduced mortality in patients hospitalized with influenza. C1 [Vandermeer, Meredith L.; Thomas, Ann R.] Oregon Publ Hlth Div, Portland, OR 97212 USA. [Kamimoto, Laurie] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. [Reingold, Arthur] Calif Emerging Infect Program, Oakland, CA USA. [Gershman, Ken] Colorado Dept Publ Hlth & Environm, Denver, CO USA. [Meek, James] Connecticut Emerging Infect Program, New Haven, CT USA. [Farley, Monica M.] Emory Univ, Sch Med, Atlanta, GA USA. [Farley, Monica M.] VA Med Ctr, Atlanta, GA USA. [Ryan, Patricia] Maryland Dept Hlth & Mental Hyg, Baltimore, MD USA. [Lynfield, Ruth] Minnesota Dept Hlth, St Paul, MN USA. [Baumbach, Joan] New Mexico Dept Hlth, Santa Fe, NM USA. [Schaffner, William] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA. [Bennett, Nancy] Univ Rochester, Sch Med & Dent, New York, NY USA. [Zansky, Shelley] New York State Dept Hlth, Emerging Infect Program, Albany, NY 12237 USA. RP Thomas, AR (reprint author), Oregon Publ Hlth Div, 800 NE Oregon St, Portland, OR 97212 USA. EM ann.thomas@state.or.us FU Centers for Disease Control and Prevention; ten study sites FX This work was funded by the Emerging Infections Program Cooperative Agreement between the ten study sites and Centers for Disease Control and Prevention. NR 28 TC 62 Z9 63 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JAN 1 PY 2012 VL 205 IS 1 BP 13 EP 19 DI 10.1093/infdis/jir695 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 866MW UT WOS:000298386200005 PM 22170954 ER PT J AU Killingley, B Enstone, JE Greatorex, J Gilbert, AS Lambkin-Williams, R Cauchemez, S Katz, JM Booy, R Hayward, A Oxford, J Bridges, CB Ferguson, NM Van-Tam, JSN AF Killingley, Ben Enstone, Joanne E. Greatorex, Jane Gilbert, Anthony S. Lambkin-Williams, Rob Cauchemez, Simon Katz, Jacqueline M. Booy, Robert Hayward, Andrew Oxford, John Bridges, Carolyn B. Ferguson, Neil M. Van-Tam, Jonathan S. Nguyen TI Use of a Human Influenza Challenge Model to Assess Person-to-Person Transmission: Proof-of-Concept Study SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID AEROSOL TRANSMISSION; RHINOVIRUS COLDS; VIRUS; NEUTRALIZATION; INFECTIONS; VOLUNTEERS; ANTIBODY; ILLNESS; DISEASE AB Background. Influenza transmission in humans remains poorly understood. In particular, the relative contribution of contact, large droplet, and aerosol transmission is unknown. The aims of this proof-of-concept study were to determine whether an experimentally induced influenza infection is transmissible between humans and whether this would form a viable platform for future studies. Methods. In a quarantine facility, healthy volunteers ("donors") were inoculated with A/Wisconsin/67/2005 (H3N2) influenza virus via intranasal drops. On study days 2 and 3 "recipient" volunteers were exposed to donors under close living conditions. Volunteers socialized for 30 hours during a 2-day period. Infection was confirmed by >= 1 positive results from polymerase chain reaction, virus culture, or serology. Results. After inoculation, 4 of 9 donors developed symptoms consistent an influenza-like illness (ILI) and 7 of 9 were proven to be influenza-infected. After exposure, 4 of 15 recipients developed symptoms of ILI and 3 of 15 were proven to be infected. Serum collected within 2 days of study initiation indicated that 1 donor and 3 recipients were seropositive at study initiation. After adjustment for preexposure immunity, the overall secondary attack rate was 25% (3 of 12). Conclusions. Experimental human exposure studies offer an attractive potential method for answering outstanding questions related to influenza transmission and the evaluation of interventions to reduce it. C1 [Killingley, Ben; Enstone, Joanne E.; Van-Tam, Jonathan S. Nguyen] Univ Nottingham, Div Epidemiol & Publ Hlth, Nottingham NG5 1PB, England. [Greatorex, Jane] Addenbrookes Hosp, Cambridge, England. [Gilbert, Anthony S.; Lambkin-Williams, Rob] Retroscreen Virol Ltd, Innovat Ctr, Queen Mary BioEnterprises, London, England. [Cauchemez, Simon; Ferguson, Neil M.] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England. [Katz, Jacqueline M.; Bridges, Carolyn B.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Booy, Robert] Natl Ctr Immunisat Res & Surveillance, Westmead, NSW, Australia. [Hayward, Andrew] UCL, Ctr Infect Dis Epidemiol, London, England. [Oxford, John] Barts & London Queen Marys Sch Med & Dent, Ctr Infect Dis, London, England. RP Killingley, B (reprint author), Univ Nottingham, Div Epidemiol & Publ Hlth, Room A40h,Clin Sci Bldg,City Hosp Campus,Hucknall, Nottingham NG5 1PB, England. EM ben.killingley@nottingham.ac.uk RI Ferguson, Neil/B-8578-2008; Hayward, Andrew/C-3268-2013; Lambkin-Williams, Robert/P-5963-2016; OI Ferguson, Neil/0000-0002-1154-8093; Hayward, Andrew/0000-0002-3549-6232; Lambkin-Williams, Robert/0000-0003-2107-0174; Nguyen-Van-Tam, Jonathan/0000-0003-2579-4655 FU Department of Health, England; UK Clinical Research Consortium [MRC G0701554]; Medical Research Council, UK [G0800453]; GlaxoSmithKline; Nobilon-Merck Sharp Dohme; Juvaris Inc; Commonwealth Serum Laboratories; F. Hoffmann-La Roche; Sanofi Pasteur; Pfizer FX This work was supported by the Department of Health, England; the UK Clinical Research Consortium (MRC G0701554); and the Medical Research Council, UK (G0800453) (to B. K.). The Centers for Disease Control and Prevention provided air samplers and laboratory testing services for the study.; B. K. has performed ad hoc consultancy work for Retroscreen Virology Ltd, a virology contract research organization. A. S. G. (medical director), R. L. W. (chief scientific officer), and J. O. (non-executive president and scientific director) are employed by Retroscreen Virology Ltd. J. M. K. has received funds from GlaxoSmithKline, Nobilon-Merck Sharp & Dohme, and Juvaris Inc for research unrelated to the current study. R. B. has received funding from Commonwealth Serum Laboratories, F. Hoffmann-La Roche, Sanofi Pasteur, GSK, and Pfizer to conduct (unrelated) research and attend and present at scientific meetings. J. N. V.-T. has received funding to attend influenza-related meetings and ad hoc lectures and received consultancy fees from several influenza antiviral drug and vaccine manufacturers (including GlaxoSmithKline), ceasing in September 2010; he has performed ad hoc consultancy for Retroscreen Virology Ltd, and his unit is currently in receipt of research funds from GSK, AstraZeneca, and F. Hoffmann-La Roche; he is a former employee of SmithKline Beecham plc (now a part of GSK), Roche Products Ltd, and Sanofi Pasteur MSD, all such appointments prior to 2005. All other authors report no potential conflicts. NR 28 TC 25 Z9 25 U1 0 U2 9 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JAN 1 PY 2012 VL 205 IS 1 BP 35 EP 43 DI 10.1093/infdis/jir701 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 866MW UT WOS:000298386200008 PM 22131338 ER PT J AU Richman, AR Coronado, GD Arnold, LD Fernandez, ME Glenn, BA Allen, JD Wilson, KM Brewer, NT AF Richman, Alice R. Coronado, Gloria D. Arnold, Lauren D. Fernandez, Maria E. Glenn, Beth A. Allen, Jennifer D. Wilson, Katherine M. Brewer, Noel T. TI Cognitive Testing of Human Papillomavirus Vaccine Survey Items for Parents of Adolescent Girls SO JOURNAL OF LOWER GENITAL TRACT DISEASE LA English DT Article DE cognitive interviewing; survey design; cervical cancer; human papillomavirus; HPV vaccine ID EPIDEMIOLOGIC RESEARCH; HEALTH-SERVICES; ACCEPTABILITY; INSTRUMENT AB Objective. Many studies have been conducted to understand what factors are associated with human papillomavirus (HPV) vaccine acceptability and completion of the 3-dose vaccination series, but few have examined whether people understand the survey items used to assess these relationships. Through a multisite collaborative effort, we developed and cognitively tested survey items that represent constructs known to affect vaccine acceptability and completion. Materials and Methods. Investigators from 7 research centers in the United States used cognitive interviewing techniques and in-person and telephone interviews to test 21 items. Four rounds of testing, revising, and retesting were conducted among racially and ethnically diverse parents (n = 62) of girls between the ages of 9 and 17 years. Results. The final survey contained 20 items on attitudes and beliefs relevant to HPV vaccine. Some parents misinterpreted statements about hypothetical vaccine harms as statements of fact. Others were unwilling to answer items about perceived disease likelihood and perceived vaccine effectiveness, because they said the items seemed to have a "right" answer that they did not know. On the basis of these and other findings from cognitive testing, we revised the wording of 14 questions to improve clarity and comprehension. We also revised instructions, response options, and item order. Conclusions. Cognitive testing of HPV vaccine survey items revealed important differences between intended and ascribed item meaning by participants. Use of the tested survey questions presented here may increase measurement validity and researchers' ability to compare findings across studies and populations. Additional testing using quantitative methods can help to further validate these items. C1 [Richman, Alice R.] Univ N Carolina, Dept Hlth Behav & Hlth Educ, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27516 USA. [Coronado, Gloria D.] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA. [Arnold, Lauren D.] Washington Univ, Sch Med, Dept Surg, Siteman Canc Ctr, St Louis, MO 63110 USA. [Fernandez, Maria E.] Univ Texas Houston, Hlth Sci Ctr, Houston, TX USA. [Glenn, Beth A.] Univ Calif Los Angeles, Sch Publ Hlth, Dept Hlth Serv, Los Angeles, CA 90024 USA. [Glenn, Beth A.] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90024 USA. [Allen, Jennifer D.] Harvard Univ, Dana Farber Canc Inst, Ctr Community Based Res, Boston, MA USA. [Wilson, Katherine M.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Brewer, Noel T.] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA. RP Richman, AR (reprint author), Univ N Carolina, Dept Hlth Behav & Hlth Educ, Gillings Sch Global Publ Hlth, 325 Rosenau Hall,CB 7440, Chapel Hill, NC 27516 USA. EM richmana@ecu.edu; ntb1@unc.edu RI Allen, Jennifer/M-2113-2015 FU Centers for Disease Control and Prevention; National Cancer Institute for the Cancer Prevention and Control Research Network at the University of California at Los Angeles School of Public Health [1-U48-DP000056]; Harvard School of Public Health/Boston School of Public Health [1-U48-DP000064]; University of North Carolina at Chapel Hill, Gillings School of Global Public Health [5-U48-DP000059]; University of Texas School of Public Health [1-U48-DP000057]; University of Washington School of Public Health and Community Medicine/Fred Hutchinson Cancer Research Center [1-U48-DP000050]; Washington University School of Medicine, Department of Surgery, Siteman Cancer Center [5-U48-DP000060]; American Cancer Society [MSRG-06-259-01-CPPB] FX Research for this publication was supported by the Centers for Disease Control and Prevention and the National Cancer Institute cooperative agreements for the Cancer Prevention and Control Research Network at the University of California at Los Angeles School of Public Health (1-U48-DP000056); Harvard School of Public Health/Boston School of Public Health (1-U48-DP000064); University of North Carolina at Chapel Hill, Gillings School of Global Public Health (5-U48-DP000059); University of Texas School of Public Health (1-U48-DP000057); University of Washington School of Public Health and Community Medicine/Fred Hutchinson Cancer Research Center (1-U48-DP000050); and Washington University School of Medicine, Department of Surgery, Siteman Cancer Center (5-U48-DP000060). In addition, the research at the University of North Carolina was supported by grants from the American Cancer Society (MSRG-06-259-01-CPPB). The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 22 TC 3 Z9 3 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1089-2591 J9 J LOW GENIT TRACT DI JI J. Low. Genit. Tract. Dis. PD JAN PY 2012 VL 16 IS 1 BP 16 EP 23 DI 10.1097/LGT.0b013e3182293a49 PG 8 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 870KP UT WOS:000298668500005 PM 21964205 ER PT J AU Eisen, RJ Piesman, J Zielinski-Gutierrez, E Eisen, L AF Eisen, Rebecca J. Piesman, Joseph Zielinski-Gutierrez, Emily Eisen, Lars TI What Do We Need to Know About Disease Ecology to Prevent Lyme Disease in the Northeastern United States? SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE disease ecology; Lyme disease; prevention; vector-borne disease; Borrelia burgdorferi ID IXODES-SCAPULARIS ACARI; AMBLYOMMA-AMERICANUM ACARI; BLACKLEGGED TICK ACARI; WHITE-TAILED DEER; MEDIUM-SIZED MAMMALS; SOUTHERN NEW-YORK; WEST-NILE-VIRUS; BORRELIA-BURGDORFERI; DAMMINI ACARI; IXODIDAE NYMPHS AB Lyme disease is the most commonly reported vector-borne disease in the United States, with the majority of cases occurring in the Northeast. It has now been three decades since the etiological agent of the disease in North America, the spirochete Borrelia burgdorferi, and its primary North American vectors, the ticks Ixodes scapularis Say and I. pacificus Cooley & Kohls, were identified. Great strides have been made in our understanding of the ecology of the vectors and disease agent, and this knowledge has been used to design a wide range of prevention and control strategies. However, despite these advances, the number of Lyme disease cases have steadily increased. In this article, we assess potential reasons for the continued lack of success in prevention and control of Lyme disease in the northeastern United States, and identify conceptual areas where additional knowledge could be used to improve Lyme disease prevention and control strategies. Some of these areas include: 1) identifying critical host infestation rates required to maintain enzootic transmission of B. burgdorferi, 2) understanding how habitat diversity and forest fragmentation impacts acarological risk of exposure to B. burgdorferi and the ability of interventions to reduce risk, 3) quantifying the epidemiological outcomes of interventions focusing on ticks or vertebrate reservoirs, and 4) refining knowledge of how human behavior influences Lyme disease risk and identifying barriers to the adoption of personal protective measures and environmental tick management. C1 [Eisen, Rebecca J.; Piesman, Joseph; Zielinski-Gutierrez, Emily] Ctr Dis Control & Prevent, Div Vector Borne Dis, Natl Ctr Emerging & Zoonot Infect Dis, Ft Collins, CO 80522 USA. [Eisen, Lars] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA. RP Eisen, RJ (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, Natl Ctr Emerging & Zoonot Infect Dis, 3150 Rampart Rd, Ft Collins, CO 80522 USA. EM dyn2@cdc.gov NR 114 TC 17 Z9 17 U1 8 U2 52 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD JAN PY 2012 VL 49 IS 1 BP 11 EP 22 DI 10.1603/ME11138 PG 12 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 873SQ UT WOS:000298903700002 PM 22308766 ER PT J AU Jordan, RA Schulze, TL Dolan, MC AF Jordan, Robert A. Schulze, Terry L. Dolan, Marc C. TI Efficacy of Plant-Derived and Synthetic Compounds on Clothing as Repellents Against Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE repellent testing; nootkatone; carvacrol; EcoSMART; permethrin ID HUMAN GRANULOCYTIC EHRLICHIOSIS; TICK-BORNE DISEASES; LYME-DISEASE; PERSONAL PROTECTION; FIELD-EVALUATION; SAMPLING METHODS; AEDES-AEGYPTI; ESSENTIAL OIL; NEW-JERSEY; DEET AB We conducted field trials to compare the relative repellent activity of two natural product compounds (nootkatone and carvacrol) with commercially available plant-derived (EcoSMART organic insect repellent) and permethrin-based (Repel Permanone) repellents against adult Ixodes scapularis Say and Amblyomma americanum (L.) (Acari: Ixodidae) by using treated coveralls. One day after treatment, nootkatone and carvacrol provided 100% repellency of I. scapularis adults, with nootkatone maintaining complete protection through 3 d, whereas carvacrol showed steadily declining repellency against I. scapularis during the 7-d course of the trials. Nootkatone was at least as effective against host-seeking A. americanum as against I. scapularis through 3 d. Carvacrol provided little protection against A. americanum adults. Both natural compounds performed well initially in comparison with the commercial products. After 7 d, nootkatone was the most effective against both species followed in order of activity by Permanone, EcoSMART, and carvacrol. Nootkatone seems to have offer considerable potential as a clothing repellent against both I. scapularis and A. americanum. C1 [Jordan, Robert A.; Schulze, Terry L.] Freehold Area Hlth Dept, Freehold, NJ 07728 USA. [Schulze, Terry L.] Terry L Schulze Phd Inc, Perrineville, NJ 08535 USA. [Dolan, Marc C.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Natl Ctr Emerging & Zoonot Infect Dis, Publ Hlth Serv,US Dept Hlth & Human Serv, Ft Collins, CO 80521 USA. RP Jordan, RA (reprint author), Freehold Area Hlth Dept, 1 Municipal Plaza, Freehold, NJ 07728 USA. EM rajordanphd@optimum.net FU Centers for Disease Control and Prevention [1U01CK000105-2]; Freehold Township, NJ; Department of Defense [ZAJS DWFP 373744] FX We thank Patricia Chizmadia, Ray Green, Eric Helms, and John Buble, NWS Earle, for continued support. We thank Gabrielle Dietrich (Centers for Disease Control and Prevention, Division of Vector-Borne Infectious Diseases [CDC, DVBID], Fort Collins, CO) for technical assistance. The current research was supported by a Cooperative Agreement (1U01CK000105-2) between the Centers for Disease Control and Prevention and Freehold Township, NJ, and funding awarded to M.C.D. (CDC, DVBID; ZAJS DWFP 373744), through the Department of Defense, Deployed Weapons Fighter Protection Program. NR 53 TC 17 Z9 17 U1 1 U2 22 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD JAN PY 2012 VL 49 IS 1 BP 101 EP 106 DI 10.1603/ME10241 PG 6 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 873SQ UT WOS:000298903700013 PM 22308777 ER PT J AU Crockett, RK Burkhalter, K Mead, D Kelly, R Brown, J Varnado, W Roy, A Horiuchi, K Biggerstaff, BJ Miller, B Nasci, R AF Crockett, Rebekah Kent Burkhalter, Kristen Mead, Daniel Kelly, Rosmarie Brown, Jeffrey Varnado, Wendy Roy, Alma Horiuchi, Kalanthe Biggerstaff, Brad J. Miller, Barry Nasci, Roger TI Culex Flavivirus and West Nile Virus in Culex quinquefasciatus Populations in the Southeastern United States SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Culex flavivirus; insect-only flavivirus; Culex quinquefasciatas; West Nile virus ID EQUINE ENCEPHALOMYELITIS VIRUS; INSECT-SPECIFIC FLAVIVIRUS; KAMITI RIVER VIRUS; ENCEPHALITIS-VIRUS; DIPTERA-CULICIDAE; YUCATAN PENINSULA; AEDES-AEGYPTI; MOSQUITOS; INFECTION; TRANSMISSION AB Little is known of the interactions between insect-only flaviviruses and other arboviruses in their mosquito hosts, or the potential public health significance of these associations. The specific aims of this study were to describe the geographic distribution, prevalence, and seasonal infection rates of Culex flavivirus (CxFV) and West Nile virus (WNV) in Culex quinquefasciatus Say in the Southeastern United States, investigate the potential association between CxFV and WNV prevalence in Cx. quinquefasciatus and describe the phylogenetic relationship among CxFV and WNV isolates from the Southeastern United States and around the world. Using ArboNET records, 11 locations were selected across Georgia, Mississippi, and Louisiana that represented a range of WNV human case incidence levels. Cx. quinquefasciatus were trapped weekly throughout the summer of 2009 and pools were screened for flavivirus RNA by reverse transcriptase polymerase chain reaction. Cx. quinquefasciatus from Georgia had significantly higher CxFV infection rates than either Mississippi or Louisiana. CxFV was not detected in Mississippi after July, and no CxFV was detected in Cx. quinquefasciatus in Louisiana. In Georgia, CxFV infection rates were variable between and within counties and over time. WNV infection rates were not significantly different across states or months, and WNV sequences from all three states were identical to each other in the envelope and NS5 gene regions. Phylogenetically, NS5 and E gene sequences from Georgia CxFV isolates clustered with CxFV from japan, Iowa, and Texas. Multiple CxFV genetic variants were found circulating simultaneously in Georgia. No evidence was found supporting an association between WNV and CxFV infection prevalence in a. quinquefasciatus. C1 [Crockett, Rebekah Kent; Burkhalter, Kristen; Horiuchi, Kalanthe; Biggerstaff, Brad J.; Miller, Barry; Nasci, Roger] Ctr Dis Control & Prevent, Div Vector Borne Dis, Arbovirus Dis Branch, Ft Collins, CO 80521 USA. [Mead, Daniel] Univ Georgia, Coll Vet Med, SE Cooperat Wildlife Dis Study, Athens, GA USA. [Kelly, Rosmarie] Georgia Div Publ Hlth Epidemiol Branch, Atlanta, GA USA. [Brown, Jeffrey; Varnado, Wendy] Mississippi Dept Hlth, Environm Serv, Jackson, MS USA. [Roy, Alma] Louisiana State Univ, Louisiana Vet Med Diagnost Lab, Baton Rouge, LA 70803 USA. RP Crockett, RK (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, Arbovirus Dis Branch, Ft Collins, CO 80521 USA. EM fxk7@cdc.gov RI Kading, Rebekah/E-5633-2017 OI Kading, Rebekah/0000-0002-4996-915X FU American Society for Microbiology FX For mosquito collection and processing in Georgia, we thank Sarah Gordan-Akhvlediani from the Southeastern Cooperative Wildlife Disease Study; Juanette Willis, John Horvath, Alan Gaines, and arbovirus technicians from the DeKalb County Board of Health; Henry Lewandowski, Bobby Moulis, and Jennifer Russel from Chatham County Mosquito Control; Patrice Harris of Fulton County Health and Wellness; Kevin Jones from the Environmental Health Department; and Erica Wyatt of Clarke Mosquito Control. From Mississippi, we thank Rickie Overby for mosquito collections from Jackson County. RJK received funding from the American Society for Microbiology. Katherine MacMillan of the Centers for Disease Control developed the map. Mary Crabtree of the Centers for Disease Control, Division of Vector-borne Diseases assisted with the phylogenetic analysis. NR 34 TC 13 Z9 14 U1 1 U2 11 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-2585 EI 1938-2928 J9 J MED ENTOMOL JI J. Med. Entomol. PD JAN PY 2012 VL 49 IS 1 BP 165 EP 174 DI 10.1603/ME11080 PG 10 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 873SQ UT WOS:000298903700021 PM 22308785 ER PT J AU Borchert, JN Eisen, RJ Holmes, JL Atiku, LA Mpanga, JT Brown, HE Graham, CB Babi, N Montenieri, JA Enscore, RE Gage, KL AF Borchert, Jeff N. Eisen, Rebecca J. Holmes, Jennifer L. Atiku, Linda A. Mpanga, Joseph T. Brown, Heidi E. Graham, Christine B. Babi, Nackson Montenieri, John A. Enscore, Russell E. Gage, Kenneth L. TI Evaluation and Modification of Off-Host Flea Collection Techniques Used in Northwest Uganda: Laboratory and Field Studies SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE flea trap; Ctenocephalides felis; Xenopsylla cheopis; flea; plague ID CTENOCEPHALIDES-FELIS; CAT FLEAS; PLAGUE; SIPHONAPTERA; PULICIDAE; EPIDEMIOLOGY; TANZANIA; BURROWS; HOMES; TRAP AB Quantifying the abundance of host-seeking fleas is critical for assessing risk of human exposure to flea-borne disease agents, including Yersinia pestis, the etiological agent of plague. Yet, reliable measures of the efficacy of existing host-seeking flea collection methods are lacking. In this study, we compare the efficacy of passive and active methods for the collection of host-seeking fleas in both the laboratory and human habitations in a plague-endemic region of northwest Uganda. In the laboratory, lighted "Kilonzo" flea traps modified with either blinking lights, the creation of shadows or the generation of carbon dioxide were less efficient at collecting Xenopsylla cheopis Rothchild and Ctenocephalides felis Bouche fleas than an active collection method using white cotton socks or cotton flannel. Passive collection using Kilonzo light traps in the laboratory collected significantly more X. cheopis than C. felis and active collection, using white socks and flannel, collected significantly more C. felis than X. cheopis. In field studies conducted in Uganda, Kilonzo traps using a flashlight were similar in their collection efficacy to Kilonzo traps using kerosene lamps. However, in contrast to laboratory studies, Kilonzo flea traps using flashlights collected a greater number of fleas than swabbing. Within human habitations in Uganda, Kilonzo traps were especially useful for collecting C. felis, the dominant species found in human habitations in this area. C1 [Borchert, Jeff N.; Eisen, Rebecca J.; Holmes, Jennifer L.; Brown, Heidi E.; Graham, Christine B.; Montenieri, John A.; Enscore, Russell E.; Gage, Kenneth L.] Ctr Dis Control & Prevent, Bacterial Dis Branch, Div Vector Borne Dis, Ft Collins, CO 80521 USA. [Atiku, Linda A.; Mpanga, Joseph T.; Babi, Nackson] Uganda Virus Res Inst, Entebbe, Uganda. RP Borchert, JN (reprint author), Ctr Dis Control & Prevent, Bacterial Dis Branch, Div Vector Borne Dis, 3150 Rampart Rd, Ft Collins, CO 80521 USA. EM gqx1@cdc.gov OI Brown, Heidi/0000-0001-8578-5510 FU CDC, Division of Vector-Borne Diseases FX We express our gratitude to Anne Laudisoit for helpful discussion on study design. This research was supported in part by the appointment of J.N.B. to the Research Participation Program at the CDC, Division of Vector-Borne Diseases, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the CDC. NR 24 TC 4 Z9 4 U1 0 U2 4 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD JAN PY 2012 VL 49 IS 1 BP 210 EP 214 DI 10.1603/ME11045 PG 5 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 873SQ UT WOS:000298903700026 PM 22308790 ER PT J AU Zhang, B Gertz, RE Liu, ZY Li, ZY Fu, WL Beall, B AF Zhang, Bo Gertz, Robed E., Jr. Liu, Zhiyong Li, Zhongya Fu, Weiling Beall, Bernard TI Characterization of highly antimicrobial-resistant clinical pneumococcal isolates recovered in a Chinese hospital during 2009-2010 SO JOURNAL OF MEDICAL MICROBIOLOGY LA English DT Article ID SEQUENTIAL MULTIPLEX PCR; DETERMINING CAPSULAR SEROTYPES; STREPTOCOCCUS-PNEUMONIAE; UNITED-STATES; CHILDREN; DISEASE; 19A AB Ninety-one consecutive pneumococcal isolates (primarily from sputum), recovered in Chongqing Southwest Hospital during a 12 month period in 2009-2010 from individuals of all ages with suspected cases of pneumococcal disease, were subjected to PCR-serotyping, Quellung reaction serotyping, antimicrobial-susceptibility testing and multilocus sequence typing (MLST). Although 20 different serotypes were observed, most isolates (69, 75.8%) were of serotypes included in the pneumococcal 13-valent conjugate vaccine (PCV13), including 33 of the 46 (71.7%) isolates recovered from individuals less than 5 years of age. The prevalent serotypes were 19F (34%), 19A (9.9%), 6B (9.9%), 23F (7.7%), 14 (6.6%) and 6A (4.4%). PCR-determined serotypes were in agreement with Quellung testing, with the exception of two serotype 33C isolates. Most or all isolates within each PCV13 serotype were represented by one genotype, with the globally disseminated MLST sequence types (STs) ST271, ST320, ST90 and ST81 each accounting for the highly resistant isolates within serotypes 19F, 19A, 6B and 23F, respectively. Sixty-six (72.50/o) isolates were resistant to combinations of beta-lactam antibiotics (BLAs). A total of 63 of these 66 (95.5%) BLA-resistant isolates were of serotypes included in PCV13; however, 3 serogroup 15 isolates were also BLA-resistant. Most isolates (88/91=96.7%) were resistant to erythromycin and clindamycin. The majority of isolates were also resistant to tetracycline (76, 84%) and to cotrimoxazole (67, 74%). This work revealed that the majority of antimicrobial-resistant isolates (50/91=54.9%) recovered in this Chinese hospital were represented by four global clones. Serotypes for these as well as more obscure strains were readily determined by using PCR. C1 [Zhang, Bo; Liu, Zhiyong; Fu, Weiling] Chongqing SW Hosp, Chongqing, Peoples R China. [Gertz, Robed E., Jr.; Li, Zhongya; Beall, Bernard] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Fu, WL (reprint author), Chongqing SW Hosp, Chongqing, Peoples R China. EM zbcq@yahoo.com.cn; bbeall@cdc.gov FU Emerging Infectious Diseases Fellowship Program; Centers for Disease Control and Prevention (CDC) FX This research was supported in part by an appointment to the Emerging Infectious Diseases Fellowship Program (B. Z.) administered by the Association of Public Health Laboratories (APHL) and funded by the Centers for Disease Control and Prevention (CDC). NR 17 TC 8 Z9 9 U1 0 U2 1 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 0022-2615 J9 J MED MICROBIOL JI J. Med. Microbiol. PD JAN PY 2012 VL 61 IS 1 BP 42 EP 48 DI 10.1099/jmm.0.035675-0 PG 7 WC Microbiology SC Microbiology GA 874QE UT WOS:000298972400006 PM 21873379 ER PT J AU Grant, FKE Suchdev, PS Flores-Ayala, R Cole, CR Ramakrishnari, U Ruth, LJ Martorell, R AF Grant, Frederick K. E. Suchdev, Parminder S. Flores-Ayala, Rafael Cole, Conrad R. Ramakrishnari, Usha Ruth, Laird J. Martorell, Reynaldo TI Correcting for Inflammation Changes Estimates of Iron Deficiency among Rural Kenyan Preschool Children SO JOURNAL OF NUTRITION LA English DT Article ID SOLUBLE TRANSFERRIN RECEPTOR; ACUTE-PHASE RESPONSE; ZINC PROTOPORPHYRIN/HEME RATIO; APPARENTLY HEALTHY; SUBCLINICAL INFLAMMATION; FERRITIN CONCENTRATIONS; PLASMA FERRITIN; INDICATORS; VITAMIN; MALARIA AB The assessment of iron status where infections are common is complicated by the effects of inflammation on iron indicators and in this study we compared approaches that adjust for this influence. Blood was collected in 680 children (aged 6-35 mo) and indicators of iron status [(hemoglobin (Hb), zinc protoporphyrin (ZP), ferritin, transferrin receptor (TfR), and TfR/ferritin index)] and subclinical inflammation [(the acute phase proteins (APP) C-reactive protein (CRP), and alpha-1-acid glycoprotein (AGP)] were determined. Malaria parasitemia was assessed. Subclinical inflammation was defined as CRP >5 mg/L and/or AGP >1 g/L). Four groups were defined based on APP levels: reference (normal CRP and AGP), incubation (raised CRP and normal AGP), early convalescence (raised CRP and AGP), and late convalescence (normal CRP and raised AGP). Correction factors (CF) were estimated as the ratios of geometric means of iron indicators to the reference group of those for each inflammation group. Corrected values of iron indicators within inflammation groups were obtained by multiplying values by their respective group CF. CRP correlated with AGP (r = 0.65; P < 0.001), ferritin (r = 0.38; P < 0.001), Hb (r = -0.27; P < 0.001), and ZP (r = 0.16; P < 0.001); AGP was correlated with ferritin (r = 0.39; P < 0.001), Hb (r = -0.29; P < 0.001), and ZP (r = 0.24; P < 0.001). Use of CF to adjust for inflammation increased the prevalence of ID based on ferritin < 12 mu g/L by 34% (from 27 to 41%). Applying the CF strengthened the expected relationship between Hb and ferritin (r = 0.10; P = 0.013 vs. r = 0.20; P < 0.001, before and after adjustment, respectively). Although the use of CF to adjust for inflammation appears indicated, further work is needed to confirm that this approach improves the accuracy of assessment of ID. J. Nutr. 142: 105-111, 2012. C1 [Grant, Frederick K. E.; Suchdev, Parminder S.; Ramakrishnari, Usha; Martorell, Reynaldo] Emory Univ, Nutr & Hlth Sci Program, Grad Div Biol & Biomed Sci, Atlanta, GA 30322 USA. [Suchdev, Parminder S.] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA. [Grant, Frederick K. E.; Flores-Ayala, Rafael; Ramakrishnari, Usha; Martorell, Reynaldo] Emory Univ, Hubert Dept Global Hlth, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Suchdev, Parminder S.; Flores-Ayala, Rafael; Ruth, Laird J.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Cole, Conrad R.] Cincinnati Childrens Hosp Med Ctr, Div Gastroenterol Hepatol & Nutr, Cincinnati, OH USA. RP Grant, FKE (reprint author), Emory Univ, Nutr & Hlth Sci Program, Grad Div Biol & Biomed Sci, Atlanta, GA 30322 USA. EM ebogrant5@yahoo.com RI Martorell, Reynaldo /I-2539-2012; Suchdev, Parmi/K-4851-2012; OI Suchdev, Parmi/0000-0002-0350-3469 FU Ellison Medical Foundation/Nevin Scrimshaw International Nutrition Foundation; CDC FX Supported in part by an Ellison Medical Foundation/Nevin Scrimshaw International Nutrition Foundation fellowship (F.K.E.G.) and the CDC (P.S.S.). The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the CDC. NR 23 TC 32 Z9 32 U1 1 U2 3 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-3166 EI 1541-6100 J9 J NUTR JI J. Nutr. PD JAN PY 2012 VL 142 IS 1 BP 105 EP 111 DI 10.3945/jn.111.146316 PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 867GR UT WOS:000298443400016 PM 22157541 ER PT J AU Rah, JH dePee, S Kraemer, K Steiger, G Bloem, MW Spiegel, P Wilkinson, C Bilukha, O AF Rah, Jee Hyun dePee, Saskia Kraemer, Klaus Steiger, Georg Bloem, Martin W. Spiegel, Paul Wilkinson, Caroline Bilukha, Oleg TI Program Experience with Micronutrient Powders and Current Evidence SO JOURNAL OF NUTRITION LA English DT Article ID KAKUMA REFUGEE CAMP; HOME FORTIFICATION; COMPLEMENTARY FOODS; IRON STATUS; CHILDREN; HEMOGLOBIN; BANGLADESH; SPRINKLES; EMERGENCY; GROWTH AB The efficacy of micronutrient powders (MNP) in the treatment of anemia in moderately anemic children aged 6-24 mo has been clearly demonstrated. The evidence of the effectiveness of MNP in large-scale programs, however, is scarce. This article describes the program experience and findings of large-scale MNP distribution in refugee camps and in an emergency context in Bangladesh, Nepal, and Kenya. The MNP contained 15-16 micronutrients as per the WHO/World Food Programme/UNICEF joint statement, whereas the iron content was reduced to 2.5 mg from NaFeEDTA in a malaria-endemic area in Kenya. Hundreds of thousands of children aged 6-59 mo and pregnant and lactating women were targeted to consume MNP either daily or every other day over an extended period of time. Extensive social marketing campaigns were undertaken to promote regular use of the product. A number of studies were embedded in the programs to assess the impact of MNP on the nutritional status of target beneficiaries. Some improvements in anemia prevalence estimates were observed in particular subgroups, but other results did not show significant improvements. A significant decrease in the prevalence of stunting was observed in Nepal and Kenya but not in Bangladesh. Diarrhea episodes decreased significantly among children receiving MNP in Nepal. A key challenge is to ensure high MNP acceptance and adherence among beneficiaries. Investigation of non-nutritional causes of anemia is warranted in settings with high compliance but no improvement in hemoglobin status. Further investigation into the most appropriate manner to use MNP in malaria endemic settings is warranted. J. Nutr. 142: 1915-1965, 2012. C1 [Rah, Jee Hyun; Kraemer, Klaus] SIGHT & LIFE, Basel, Switzerland. [dePee, Saskia; Bloem, Martin W.] World Food Programme, Strategy & Programme Support Div, Nutr Serv, Rome, Italy. [Steiger, Georg] DSM Nutr Prod, Basel, Switzerland. [Spiegel, Paul; Wilkinson, Caroline] United Nations High Commissioner Refugees, Geneva, Switzerland. [Bilukha, Oleg] Ctr Dis Control & Prevent, Ctr Global Hlth, Atlanta, GA USA. RP Rah, JH (reprint author), SIGHT & LIFE, Basel, Switzerland. EM Jee-Hyun.Rah@dsm.com FU Sight and Life, Basel, Switzerland FX Published in a supplement to The Journal of Nutrition. Presented at the workshop "Multiple Micronutrient Nutrition: Evidence from History to Science to Effective Programs," held at the 2nd World Congress of Public Health Nutrition in Porto, Portugal, September 23-25, 2010. The supplement coordinators were Klaus Kraemer, Sight and Life, Basel, Switzerland and Richard D. Semba, Johns Hopkins University School of Medicine, Baltimore, Maryland. Supplement coordinator disclosures: Klaus Kraemer is employed by Sight and Life, a humanitarian initiative of DSM Nutritional Products Ltd., Basel, Switzerland. Richard D. Semba has no conflicts of interest. The Acting Editor-in-Chief for this supplement was Jesse Gregory. Acting Editor-in-Chief disclosure: Jesse Gregory has no conflicts of interest. The supplement is the responsibility of the Guest Editor to whom the Editor of The Journal of Nutrition has delegated supervision of both technical conformity to the published regulations of The Journal of Nutrition and general oversight of the scientific merit of each article. The Guest Editor for the supplement was Marian Neuhouser. Guest Editor disclosure: Marian Neuhouser has no conflicts of interest. The workshop was supported by a grant from Sight and Life, Basel, Switzerland. The contents are solely the responsibility of the authors and do not necessarily represent the official views of the organization of which the organizers are affiliated. Publication costs for this supplement were defrayed in part by the payment of page charges. This publication must hereby be marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact. The opinions expressed in this publication are those of the authors and are not attributable to the sponsors or the publisher, Editor, or Editorial Board of The Journal of Nutrition. NR 18 TC 7 Z9 8 U1 1 U2 9 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-3166 J9 J NUTR JI J. Nutr. PD JAN PY 2012 VL 142 IS 1 BP 191S EP 196S DI 10.3945/jn.111.140004 PG 6 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 867GR UT WOS:000298443400030 PM 22131547 ER PT J AU Utterback, DF Charles, LE Schnorr, TM Tiesman, HM Storey, E Vossenas, P AF Utterback, David F. Charles, Luenda E. Schnorr, Teresa M. Tiesman, Hope M. Storey, Eileen Vossenas, Pamela TI Occupational Injuries, Illnesses, and Fatalities Among Workers in the Services Sector Industries 2003 to 2007 SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID WORKPLACE INJURIES; WASHINGTON-STATE; US WORKERS; HIGH-RISK; COMPENSATION; SURVEILLANCE; PREVENTION; MORTALITY; DISEASE; LAW AB Objective: Provide descriptive statistics and discuss priorities for injury and fatality risks among services sector workers. Methods: Bureau of Labor Statistics Survey of Occupational Injuries and Illnesses and Census of Fatal Occupational Injuries data for 2003 to 2007 were analyzed to identify occupational injury and fatality risks for services sector industry groups. Results: Many services sector industry groups experienced, on average, greater than one occupational fatality per week, and survey of occupational injuries and illnesses days-away-from-work rates in excess of those for all US workers. Overall, transportation incidents and homicides are leading factors contributing to fatalities. Conclusions: These results indicate the need for adoption of safety and health prevention practices in numerous industry groups. For groups that experience elevated injury and fatality rates, priorities for research and intervention can be identified through these data. C1 [Utterback, David F.; Charles, Luenda E.; Schnorr, Teresa M.; Tiesman, Hope M.; Storey, Eileen] NIOSH, Cincinnati, OH 45226 USA. [Vossenas, Pamela] Unite Here, New York, NY USA. RP Utterback, DF (reprint author), NIOSH, 4676 Columbia Pkwy, Cincinnati, OH 45226 USA. EM dutterback@cdc.gov NR 40 TC 2 Z9 2 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD JAN PY 2012 VL 54 IS 1 BP 31 EP 41 DI 10.1097/JOM.0b013e3182398e36 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 875HW UT WOS:000299022000009 PM 22193113 ER PT J AU Larson, TC Antao, VC Bove, FJ Cusack, C AF Larson, Theodore C. Antao, Vinicius C. Bove, Frank J. Cusack, Caroline TI Association Between Cumulative Fiber Exposure and Respiratory Outcomes Among Libby Vermiculite Workers SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID TREMOLITE ACTINOLITE; RADIOGRAPHIC CHANGES; OCCUPATIONAL COHORT; ASBESTOS EXPOSURE; PLEURAL PLAQUES; LUNG-FUNCTION; FOLLOW-UP; MINERS; MONTANA; MORTALITY AB Objective: To examine the association between cumulative fiber exposure and health outcomes in workers (n = 336) with Libby amphibole exposure. Methods: Exposure response relationships were explored by the use of logistic regression, with cumulative fiber exposure modeled in categories and as a continuous variable. Results: The use of spline functions with lifetime cumulative fiber exposure as a continuous variable showed that the odds of localized pleural thickening were significantly elevated at less than I f/cc-y. Odds of parenchymal abnormalities, restrictive spirometry, and chronic bronchitis were also significantly elevated at 108, 166, and 24. f/cc-y, respectively. Conclusions: The odds of several pulmonary health outcomes are correlated with cumulative exposure to Libby amphibole. That relatively low-lifetime cumulative exposures are associated with localized pleural thickening has implications for the non cancer-risk assessment for Libby amphibole. C1 [Larson, Theodore C.; Antao, Vinicius C.; Bove, Frank J.; Cusack, Caroline] Agcy Tox Subst & Dis Registry, Div Hlth Studies, Atlanta, GA 30341 USA. RP Larson, TC (reprint author), Agcy Tox Subst & Dis Registry, Div Hlth Studies, 4770 Buford Hwy NE,MS F57, Atlanta, GA 30341 USA. EM thl3@cdc.gov RI Antao, Vinicius/B-5395-2013 OI Antao, Vinicius/0000-0002-8201-9973 NR 37 TC 11 Z9 11 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD JAN PY 2012 VL 54 IS 1 BP 56 EP 63 DI 10.1097/JOM.0b013e31823c141c PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 875HW UT WOS:000299022000012 PM 22227874 ER PT J AU Brustrom, J Thibadeau, J John, L Liesmann, J Rose, S AF Brustrom, Jennifer Thibadeau, Judy John, Lisa Liesmann, Jaime Rose, Shyanika TI Care Coordination in the Spina Bifida Clinic Setting: Current Practice and Future Directions SO JOURNAL OF PEDIATRIC HEALTH CARE LA English DT Article DE Spina bifida; care coordination ID MODEL AB Introduction: Although the potential benefits of care coordination are widely recognized, little is known about care coordination in the multidisciplinary spina bifida clinic setting. This study examined several aspects of care coordination in this environment. Method: We conducted semi-structured interviews with clinic staff (N=43) and focus groups with caregivers (N=38) at seven spina bifida clinics in the United States. Results: Clinic staff described several primary goals of care coordination, including coordinating multiple services during one visit to ease the burden on families. Although the structure of care coordination varied across the clinics, several clinics had a dedicated care coordinator. Barriers and facilitators to care coordination included staffing issues, clinic day logistics, community resources, and family-related concerns. Despite challenges associated with care coordination processes, clinic staff and caregivers alike believed that care coordination is beneficial. Discussion: Study findings suggest ways that care might be coordinated optimally in spina bifida clinics. A synthesis of these findings for clinics interested in implementing care coordination or improving the care coordination services they currently offer is provided. J Pediatr Health Care. (2012) 26, 16-26. C1 [Brustrom, Jennifer; Rose, Shyanika] Battelle Ctr Publ Hlth Res & Evaluat, Atlanta, GA 30329 USA. [Thibadeau, Judy] Ctr Dis Control & Prevent, Natl Spina Bifida Program, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [John, Lisa; Liesmann, Jaime] Battelle Ctr Publ Hlth Res & Evaluat, St Louis, MO USA. RP Brustrom, J (reprint author), Battelle Ctr Publ Hlth Res & Evaluat, 2987 Clairmont Rd,Ste 450, Atlanta, GA 30329 USA. EM brustromj@battelle.org FU Centers for Disease Control and Prevention, Office of Strategy and Innovation FX Funding for this study was provided by the Centers for Disease Control and Prevention, Office of Strategy and Innovation. NR 11 TC 5 Z9 6 U1 1 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0891-5245 J9 J PEDIATR HEALTH CAR JI J. Pediatr. Health Care PD JAN-FEB PY 2012 VL 26 IS 1 BP 16 EP 26 DI 10.1016/j.pedhc.2010.06.003 PG 11 WC Health Policy & Services; Nursing; Pediatrics SC Health Care Sciences & Services; Nursing; Pediatrics GA 873CV UT WOS:000298859400006 PM 22153140 ER PT J AU Lavelle, TA Uyeki, TM Prosser, LA AF Lavelle, Tara A. Uyeki, Timothy M. Prosser, Lisa A. TI Cost-Effectiveness of Oseltamivir Treatment for Children with Uncomplicated Seasonal Influenza SO JOURNAL OF PEDIATRICS LA English DT Article ID A H1N1 VIRUS; RESPIRATORY SYNCYTIAL VIRUS; IMMUNIZATION PRACTICES ACIP; ACUTE OTITIS-MEDIA; UNITED-STATES; RESISTANT INFLUENZA; NEURAMINIDASE INHIBITORS; ADVISORY-COMMITTEE; ANTIVIRAL THERAPY; RAPID DETECTION AB Objective To evaluate the cost-effectiveness of oseltamivir treatment for seasonal influenza in children and consider the impact of oseltamivir resistance on these findings. Study design We developed a model to evaluate 1-year clinical and economic outcomes associated with 3 outpatient management strategies for unvaccinated children with influenza-like-illness: no antiviral treatment; diagnostic testing and oseltamivir treatment when positive; and empiric oseltamivir treatment. The model depicted a hypothetical non-pandemic influenza season with a 29% level of oseltamivir resistance in circulating viruses, and 14% to 54% probability of seasonal influenza with influenza-like-illness. Strategies were compared with incremental cost-effectiveness ratios. Results In our primary analysis, empiric oseltamivir treatment consistently produced the greatest benefit. The incremental cost-effectiveness of this alternative, compared with testing and treating, was <$100 000 per quality-adjusted life year gained in all age groups except the oldest. The testing strategy was consistently more effective compared with no treatment and cost between $25 900 and $71 200 per quality-adjusted life year gained, depending on age. Results were sensitive to the prevalence of oseltamivir resistance in circulating viruses. Conclusion Empiric oseltamivir treatment of seasonal influenza is associated with favorable cost-effectiveness ratios, particularly in children aged 1 to <12 years, but ratios are highly dependent on the prevalence of oseltamivir resistance among circulating influenza viruses. (J Pediatr 2012;160:67-73). C1 [Lavelle, Tara A.] Harvard Univ, Sch Publ Hlth, Ctr Hlth Decis Sci, Boston, MA 02115 USA. [Lavelle, Tara A.] Harvard Univ, Hlth Policy Program, Cambridge, MA 02138 USA. [Uyeki, Timothy M.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. [Prosser, Lisa A.] Univ Michigan, Sch Med, Child Hlth Evaluat & Res Unit, Ann Arbor, MI USA. [Prosser, Lisa A.] Harvard Univ, Sch Med, Ctr Child Hlth Care Studies, Boston, MA 02115 USA. [Prosser, Lisa A.] Harvard Pilgrim Hlth Care, Boston, MA USA. RP Lavelle, TA (reprint author), Harvard Univ, Sch Publ Hlth, Ctr Hlth Decis Sci, 718 Huntington Ave,2nd Floor, Boston, MA 02115 USA. EM tlavelle@fas.harvard.edu FU Harvard/Centers for Disease Control and Prevention Joint Initiative for Vaccine Economics; National Institutes of Health [5K24HD47667]; National Library of Medicine [T15 LM 007092]; Novartis Health Economics and Outcomes Research Training Fellowship; National Institute of Mental Health [T32 MH019733-17] FX Supported by the Harvard/Centers for Disease Control and Prevention Joint Initiative for Vaccine Economics and National Institutes of Health (grant 5K24HD47667). T. L. was also supported by the National Library of Medicine's Biomedical Informatics Research Training Grant (T15 LM 007092), the Novartis Health Economics and Outcomes Research Training Fellowship Award, and the National Institute of Mental Health's Research Training Grant (T32 MH019733-17). The views expressed are those of the authors and do not necessarily reflect the policies of the Centers for Disease Control and Prevention. The authors declare no conflicts of interest. NR 58 TC 7 Z9 7 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 J9 J PEDIATR-US JI J. Pediatr. PD JAN PY 2012 VL 160 IS 1 BP 67 EP U123 DI 10.1016/j.jpeds.2011.07.001 PG 13 WC Pediatrics SC Pediatrics GA 863DM UT WOS:000298143000018 PM 21917267 ER PT J AU Abubakar, I Gautret, P Brunette, GW Blumberg, L Johnson, D Poumerol, G Memish, ZA Barbeschi, M Khan, AS AF Abubakar, Ibrahim Gautret, Philippe Brunette, Gary W. Blumberg, Lucille Johnson, David Poumerol, Gilles Memish, Ziad A. Barbeschi, Maurizio Khan, Ali S. TI Global perspectives for prevention of infectious diseases associated with mass gatherings SO LANCET INFECTIOUS DISEASES LA English DT Article ID W135 MENINGOCOCCAL DISEASE; HAJJ PILGRIMS; NEISSERIA-MENINGITIDIS; MUSIC-FESTIVAL; WORLD-CUP; SEROGROUP W135; SOUTH-AFRICA; MYCOBACTERIUM-TUBERCULOSIS; RESPIRATORY-INFECTIONS; TRIATHLON PARTICIPANTS AB We assess risks of communicable diseases that are associated with mass gatherings (MGs), outline approaches to risk assessment and mitigation, and draw attention to some key challenges encountered by organisers and participants. Crowding and lack of sanitation at MGs can lead to the emergence of infectious diseases, and rapid population movement can spread them across the world. Many infections pose huge challenges to planners of MGs; however, these events also provide an opportunity to engage in public health action that will benefit host communities and the countries from which participants originate. C1 [Abubakar, Ibrahim] Hlth Protect Agcy, TB Sect, London NW9 5EQ, England. [Abubakar, Ibrahim] Univ E Anglia, Norwich Med Sch, Norwich NR4 7TJ, Norfolk, England. [Gautret, Philippe] N Univ Hosp, Infect Dis & Trop Med Unit, Marseille, France. [Brunette, Gary W.] Ctr Dis Control & Prevent, Travelers Hlth Branch, Div Global Migrat & Quarantine, Atlanta, GA USA. [Khan, Ali S.] Ctr Dis Control & Prevent, Off Publ Hlth Preparedness & Response, Atlanta, GA USA. [Blumberg, Lucille] Natl Inst Communicable Dis, Natl Hlth Lab Serv, Johannesburg, South Africa. [Johnson, David] Sanofi Pasteur, Lyon, France. [Poumerol, Gilles; Barbeschi, Maurizio] WHO, CH-1211 Geneva, Switzerland. [Memish, Ziad A.] Minist Hlth, Prevent Med Directorate, Riyadh, Saudi Arabia. [Memish, Ziad A.] Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia. [Khan, Ali S.] Dept Hlth & Human Serv, Atlanta, GA USA. RP Abubakar, I (reprint author), Hlth Protect Agcy, TB Sect, London NW9 5EQ, England. EM ibrahim.abubakar@hpa.org.uk OI Abubakar, Ibrahim/0000-0002-0370-1430 FU UK National Institute for Health Research; European Union FX We received no external funding for this Review. All authors contributed to The Lancet conference on MG Medicine: implications and opportunities for global health security, Jeddah, Saudi Arabia, Oct 23-25, 2010. IA receives funding from the UK National Institute for Health Research and the European Union for his research work. We gratefully acknowledge Louise Bradshaw, Health Protection Agency, London, UK, for proofreading the Review. NR 98 TC 81 Z9 83 U1 0 U2 13 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1473-3099 EI 1474-4457 J9 LANCET INFECT DIS JI Lancet Infect. Dis. PD JAN PY 2012 VL 12 IS 1 BP 66 EP 74 DI 10.1016/S1473-3099(11)70246-8 PG 9 WC Infectious Diseases SC Infectious Diseases GA 868IB UT WOS:000298515900021 PM 22192131 ER PT J AU Kit, BK Simon, AE Ogden, CL Akinbami, LJ AF Kit, Brian K. Simon, Alan E. Ogden, Cynthia L. Akinbami, Lara J. TI Trends in Preventive Asthma Medication Use Among Children and Adolescents, 1988-2008 SO PEDIATRICS LA English DT Article DE asthma; anti-asthmatic agents; health care disparities; medically uninsured; quality indicators; health care ID HEALTH-CARE UTILIZATION; ACTING BETA-AGONISTS; INHALED CORTICOSTEROIDS; PERSISTENT ASTHMA; CHILDHOOD ASTHMA; UNITED-STATES; INADEQUATE THERAPY; PEDIATRIC ASTHMA; URBAN CHILDREN; PRESCRIPTION AB OBJECTIVE: To examine trends in preventive asthma medication (PAM) use among children with current asthma in the United States from 1988 to 2008. METHODS: We performed a cross-sectional analysis of PAM use among 2499 children aged 1 to 19 years with current asthma using nationally representative data from the National Health and Nutrition Examination Survey (NHANES) during 3 time periods: 1988-1994, 1999-2002, and 2005-2008. PAMs included inhaled corticosteroids, leukotriene receptor antagonists, long-acting beta-agonists, mast-cell stabilizers, and methylxanthines. RESULTS: Among children with current asthma, there was an increase in the use of PAMs from 17.8% (SE: 3.3) in 1988-1994 to 34.9% (SE: 3.3) in 2005-2008 (P < .001 for trend). Adjusting for age, gender, race/ethnicity, and health insurance status, the odds of PAM use were higher in 2005-2008 compared with 1988-1994 (adjusted odds ratio [a0R] = 2.6; 95% confidence interval [CI]: 1.5-4.5). A multivariate analysis, combining all 3 time periods, showed lower use of PAMs among non-Hispanic black (aOR = 0.5 [95% CI: 0.4-0.7]) and Mexican American (aOR = 0.6 [95% CI: 0.4-0.9]) children compared to non-Hispanic white children. PAM use was also lower in 12 to 19 year olds compared with 1 to 5 year olds and also in children who did not have health insurance compared with those who did. CONCLUSIONS: Between 1988 and 2008, the use of PAM increased among children with current asthma. Non-Hispanic black and Mexican American children, adolescents aged 12 to 19 years, and uninsured children with current asthma had lower use of PAM. Pediatrics 2012;129:62-69 C1 [Kit, Brian K.; Ogden, Cynthia L.] Ctr Dis Control & Prevent, Div Hlth & Nutr Examinat Surveys, Hyattsville, MD USA. [Simon, Alan E.; Akinbami, Lara J.] Ctr Dis Control & Prevent, Off Anal & Epidemiol, Natl Ctr Hlth Stat, Hyattsville, MD USA. [Kit, Brian K.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Sci Educ & Profess Dev Program Off, Atlanta, GA USA. [Kit, Brian K.; Akinbami, Lara J.] US PHS, Rockville, MD USA. RP Kit, BK (reprint author), 3311 Toledo Rd,Room 4419, Hyattsville, MD 20782 USA. EM igd0@cdc.gov NR 61 TC 30 Z9 30 U1 1 U2 6 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD JAN PY 2012 VL 129 IS 1 BP 62 EP 69 DI 10.1542/peds.2011-1513 PG 8 WC Pediatrics SC Pediatrics GA 870BT UT WOS:000298644800043 PM 22144697 ER PT J AU Hambidge, SJ Ross, C Glanz, J McClure, D Daley, MF Xu, S Shoup, JA Narwaney, K Baggs, J Weintraub, E AF Hambidge, Simon J. Ross, Colleen Glanz, Jason McClure, David Daley, Matthew F. Xu, Stan Shoup, Jo Ann Narwaney, Komal Baggs, James Weintraub, Eric CA Vaccine Safety Datalink Team TI Trivalent Inactivated Influenza Vaccine Is Not Associated With Sickle Cell Crises in Children SO PEDIATRICS LA English DT Article DE children and adolescents; childhood immunization; influenza vaccine; sickle cell disease; vaccines ID SAFETY DATALINK PROJECT; VIRUS-VACCINE; DISEASE AB BACKGROUND AND OBJECTIVES: Children with sickle cell disease are considered at high risk for complications from influenza infection and are recommended to receive annual influenza vaccination. However, data on the safety of influenza vaccination in children with sickle cell anemia are sparse. METHODS: Using a retrospective cohort of children aged 6 months to 17 years in 8 managed care organizations that comprise the Vaccine Safety Datalink and who had a diagnosis of sickle cell anemia from 1999 to 2006, we conducted matched case-control and self-controlled case series studies to examine the association of trivalent inactivated influenza vaccination with hospitalization for sickle cell crisis in the 2 weeks after vaccination. RESULTS: From an original pool of 1085 pediatric subjects with a diagnosis of sickle cell anemia, we identified 179 children with at least 1 sickle cell crisis during any influenza season (October 1-March 31). In the matched case-control study (matching on age category, gender, Vaccine Safety Datalink site, and season), the odds ratio of hospitalization for a crisis in vaccinated compared with unvaccinated children was not significant: 1.3 (95% confidence interval 0.8-2.2). In the self-controlled case series study of hospitalized cases, the incident rate ratio for hospitalization with sickle cell crisis in the 2 weeks after trivalent inactivated influenza vaccination was also not significant: 1.2 (95% confidence interval 0.75-1.95). CONCLUSION: This large cohort study did not find an association of influenza vaccination and hospitalization for sickle cell crises in children with sickle cell anemia. Pediatrics 2012; 129: e54-e59 C1 [Hambidge, Simon J.; Ross, Colleen; Glanz, Jason; McClure, David; Daley, Matthew F.; Xu, Stan; Shoup, Jo Ann; Narwaney, Komal] Kaiser Permanente Colorado, Inst Hlth Res, Denver, CO USA. [Hambidge, Simon J.] Denver Hlth, Dept Community Hlth Serv, Denver, CO USA. [Hambidge, Simon J.; Daley, Matthew F.] Univ Colorado, Sch Med, Dept Pediat, Aurora, CO USA. [Hambidge, Simon J.; Glanz, Jason] Univ Colorado, Sch Publ Hlth, Dept Epidemiol, Aurora, CO USA. [Baggs, James; Weintraub, Eric] Ctr Dis Control & Prevent, Immunizat Safety Off, Div Healthcare Qual & Promot, Atlanta, GA USA. RP Hambidge, SJ (reprint author), Mail Code 1914,660 Bannock St, Denver, CO 80207 USA. EM simon.hambidge@dhha.org OI Baggs, James/0000-0003-0757-4683; Jacobsen, Steven/0000-0002-8174-8533; Irving, Stephanie/0000-0001-7437-6797; Naleway, Allison/0000-0001-5747-4643 FU Sanofi Pasteur; GSK; Novartis; MedImmune; Protein Sciences; Merck; Wyeth/Pfizer; Pfizer; Centers for Disease Control and Prevention [200-2002-00732] FX Dr Baxter reports receiving grants from Sanofi Pasteur, GSK, Novartis, MedImmune, Protein Sciences, and Merck. Dr Jackson reports consulting work for Sanofi Pasteur, GSK, and Novartis; receipt of grant funding from Sanofi Pasteur, GSK, Novartis, and Wyeth/Pfizer; and additional support from Pfizer and Novartis. The other authors have indicated they have no financial relationships relevant to this article to disclose.; Financial support for this study was provided in full [if applicable; in part] by the Centers for Disease Control and Prevention (contract number 200-2002-00732), through America's Health Insurance Plans. NR 18 TC 5 Z9 5 U1 0 U2 1 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD JAN PY 2012 VL 129 IS 1 BP E54 EP E59 DI 10.1542/peds.2011-1294 PG 6 WC Pediatrics SC Pediatrics GA 870BT UT WOS:000298644800008 PM 22157132 ER PT J AU Whitmore, SK Taylor, AW Espinoza, L Shouse, RL Lampe, MA Nesheim, S AF Whitmore, Suzanne K. Taylor, Allan W. Espinoza, Lorena Shouse, R. Luke Lampe, Margaret A. Nesheim, Steven TI Correlates of Mother-to-Child Transmission of HIV in the United States and Puerto Rico SO PEDIATRICS LA English DT Article DE HIV; risk factors; United States; vertical infectious disease transmission ID HUMAN-IMMUNODEFICIENCY-VIRUS; PERINATAL TRANSMISSION; RISK-FACTORS; MISSED OPPORTUNITIES; VERTICAL TRANSMISSION; INFECTED WOMEN; ZIDOVUDINE USE; TYPE-1; PREVENTION; INTRAPARTUM AB OBJECTIVE: The goal of this study was to examine associations between demographic, behavioral, and clinical variables and mother-to-child HIV transmission in 15 US jurisdictions for birth years 2005 through 2008. METHODS: The study used Enhanced Perinatal Surveillance system data for HIV-infected women who gave birth to live infants. Multivariable logistic regression was used to assess variables associated with mother-to-child transmission. RESULTS: Among 8054 births, 179 infants (2.2%) were diagnosed with HIV infection. Half of the births had at least 1 missed prevention opportunity: 74.3% of infected infants, 52.1% of uninfected infants. Among 7757 mother-infant pairs with sufficient data for analysis, the odds of having an HIV-infected infant were higher for women who received late testing or no prenatal antiretroviral medications (odds ratio: 2.5 [95% confidence interval (CI): 1.5-4.0] and 3.5 [95% CI: 2.0-6.4], respectively). The odds for mothers who breastfed were 4.6 times (95% CI: 2.2-9.8) the odds for those who did not breastfeed. The adjusted odds for women with CD4 counts <200 cells per microliter were 2.4 times (95% CI: 1.4-4.2) those for women with CD4 counts >= 500 cells per microliter. The odds for women who abused substances were twice (95% CI: 1.4-2.9) those for women who did not. CONCLUSIONS: The odds of having an HIV-infected infant were higher among HIV-infected women who were tested late, had no antiretroviral medications, abused substances, breastfed, or had lower CD4 cell counts. Increases in earlier HIV diagnosis, substance abuse treatment, avoidance of breastfeeding, and use of prenatal antiretroviral medications are critical in eliminating perinatal HIV infections in the United States. Pediatrics 2012; 129: e74-e81 C1 [Whitmore, Suzanne K.; Taylor, Allan W.; Espinoza, Lorena; Shouse, R. Luke; Lampe, Margaret A.; Nesheim, Steven] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. RP Whitmore, SK (reprint author), 1600 Clifton Rd NE,MS E-47, Atlanta, GA 30333 USA. EM SWhitmore@cdc.gov NR 43 TC 31 Z9 32 U1 0 U2 6 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD JAN PY 2012 VL 129 IS 1 BP E74 EP E81 DI 10.1542/peds.2010-3691 PG 8 WC Pediatrics SC Pediatrics GA 870BT UT WOS:000298644800011 PM 22144694 ER PT J AU Coleman, CN Whitcomb, RC Miller, CW Noska, MA AF Coleman, C. Norman Whitcomb, Robert C., Jr. Miller, Charles W. Noska, Michael A. TI Commentary on the Combined Disaster in Japan SO RADIATION RESEARCH LA English DT Editorial Material C1 [Coleman, C. Norman] NCI, Radiat Res Program, Bethesda, MD 20892 USA. [Coleman, C. Norman] Off Assistant Secretary Preparedness & Response, Bethesda, MD USA. [Whitcomb, Robert C., Jr.; Miller, Charles W.] Ctr Dis Control & Prevent, Radiat Studies Branch, Atlanta, GA USA. [Noska, Michael A.] US Dept HHS, US FDA, Silver Spring, MD USA. RP Coleman, CN (reprint author), Execut Plaza N,6130 Execut Blvd,Rm 6014, Rockville, MD 20852 USA. EM ccoleman@mail.nih.gov FU Intramural CDC HHS [CC999999] NR 5 TC 1 Z9 1 U1 1 U2 1 PU RADIATION RESEARCH SOC PI LAWRENCE PA 810 E TENTH STREET, LAWRENCE, KS 66044 USA SN 0033-7587 J9 RADIAT RES JI Radiat. Res. PD JAN PY 2012 VL 177 IS 1 BP 15 EP 17 DI 10.1667/RRXX40.1 PG 3 WC Biology; Biophysics; Radiology, Nuclear Medicine & Medical Imaging SC Life Sciences & Biomedicine - Other Topics; Biophysics; Radiology, Nuclear Medicine & Medical Imaging GA 874FA UT WOS:000298939600002 PM 22103272 ER PT J AU Nakata, A Takahashi, M Irie, M AF Nakata, Akinori Takahashi, Masaya Irie, Masahiro TI Association of overtime work with cellular immune markers among healthy daytime white-collar employees SO SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH LA English DT Article DE immune system; natural killer cell; occupational health; overtime work; work condition ID NATURAL-KILLER-CELL; ELECTRIC-POWER PLANT; PERCEIVED JOB STRESS; AGED MALE WORKERS; LIFE-STYLES; SLEEP DISTURBANCES; PROSPECTIVE COHORT; JAPANESE WORKERS; T-LYMPHOCYTES; FATIGUE AB Nakata A, Takahashi M, Irie M. Association of overtime work with cellular immune markers among healthy daytime white-collar employees. Scand J Work Environ Health. 2012;38(1):56-64. doi:10.5271/sjweh.3183 Objective Even though overtime work has been suspected to be a risk factor for ill health, little research has been done to determine the underlying immunological mechanisms. This study investigated the association between overtime work and cellular immunity among Japanese white-collar workers. Methods A total of 306 healthy, full-time, non-shift, daytime employees (165 men and 141 women), aged 22-69 (mean 36) years, provided a blood sample for the measurement of circulating immune [natural killer (NK), B, and T] cells and NK cell cytotoxicity (NKCC) and completed a questionnaire survey including overtime/month. Blood samples were collected between 09.00-11.00 hours during working days and participants completed the questionnaire within the two weeks prior to the blood sampling. Stepwise linear regression analyses controlling for confounders were carried out to examine the relationship between overtime work and immune markers. Results Overtime work was mainly related to short sleep duration, increased weight, and reduced job satisfaction, and it was more prevalent among men than women and among younger and married employees. Amount of overtime was inversely associated with NK (CD3-CD56+) cell counts (beta=-0.145; P=0.032) but was not associated with NKCC, NKCC/NK cell ratio, or T or B cells. Conclusions The NK cell is a lymphocyte that possesses killer activity against tumor and virus-infected cells and constitutes a major component of the innate immune system. A decrease of NK cell counts from overtime work suggests a dampened innate immune defense. However, the finding needs to be further validated with a well-designed study using objective overtime measures. C1 [Nakata, Akinori] NIOSH, Div Appl Res & Technol, Cincinnati, OH 45226 USA. [Takahashi, Masaya] NIOSH, Kanagawa, Japan. [Irie, Masahiro] Kyushu Univ, Inst Hlth Sci, Fukuoka 812, Japan. RP Nakata, A (reprint author), NIOSH, Div Appl Res & Technol, 4676 Columbia Pkwy,MS C24, Cincinnati, OH 45226 USA. EM cji5@cdc.gov NR 47 TC 5 Z9 5 U1 3 U2 12 PU SCANDINAVIAN JOURNAL WORK ENVIRONMENT & HEALTH PI HELSINKI PA TOPELIUKSENKATU 41A, SF-00250 HELSINKI, FINLAND SN 0355-3140 J9 SCAND J WORK ENV HEA JI Scand. J. Work Environ. Health PD JAN PY 2012 VL 38 IS 1 BP 56 EP 64 DI 10.5271/sjweh.3183 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 871XK UT WOS:000298770800007 PM 21766158 ER PT J AU Mayer, KH Bush, T Henry, K Overton, ET Hammer, J Richardson, J Wood, K Conley, L Papp, J Caliendo, AM Patel, P Brooks, JT AF Mayer, Kenneth H. Bush, Timothy Henry, Keith Overton, Edgar T. Hammer, John Richardson, Jean Wood, Kathy Conley, Lois Papp, John Caliendo, Angela M. Patel, Pragna Brooks, John T. CA SUN Investigators TI Ongoing Sexually Transmitted Disease Acquisition and Risk-Taking Behavior Among US HIV-Infected Patients in Primary Care: Implications for Prevention Interventions SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID ACID AMPLIFICATION TESTS; UNITED-STATES; SAN-FRANCISCO; VIRAL LOAD; PROBABILITY SAMPLE; HOMOSEXUAL-MEN; BISEXUAL MEN; SEX; SYPHILIS; VIRUS AB Background: To better understand the factors associated with HIV-and sexually transmitted disease (STD)-transmitting behavior among HIV-infected persons, we estimated STD prevalence and incidence and associated risk factors among a diverse sample of HIV-infected patients in primary care. Methods: We analyzed data from 557 participants in the SUN Study, a prospective observational cohort of HIV-infected adults in primary care in 4 US cities. At enrollment and 6 months thereafter, participants completed an audio computer-assisted self-interview about their sexual behavior, and were screened for genitourinary, rectal, and pharyngeal Neisseria gonorrhoeae and Chlamydia trachomatis infections by nucleic acid amplification testing, and for serologic evidence of syphilis. Women provided cervicovaginal samples and men provided urine to screen for Trichomonas vaginalis by polymerase chain reaction. Results: Thirteen percent of participants had a prevalent STD at enrollment and 7% an incident STD 6 months later. The most commonly diagnosed infections were rectal chlamydia, oropharyngeal gonorrhea, and chlamydial urethritis among the men and trichomoniasis among the women. Other than trichomoniasis, 94% of incident STDs were identified in men who have sex with men. Polysubstance abuse other than marijuana, and having >= 4 sex partners in the 6 months before testing were associated with diagnosis of an incident STD. Conclusions: STDs were commonly diagnosed among contemporary HIV-infected patients receiving routine outpatient care, particularly among sexually active men who have sex with men who used recreational drugs. These findings underscore the need for frequent STD screening, prevention counseling, and substance abuse treatment for HIV-infected persons in care. C1 [Mayer, Kenneth H.] Brown Univ, Providence, RI 02912 USA. [Mayer, Kenneth H.] Miriam Hosp, Providence, RI 02906 USA. [Bush, Timothy; Conley, Lois; Patel, Pragna; Brooks, John T.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. [Henry, Keith] Hennepin Cty Med Ctr, Minneapolis, MN 55415 USA. [Overton, Edgar T.] Washington Univ, Sch Med, St Louis, MO USA. [Hammer, John] Rose Med Ctr, Denver, CO USA. [Richardson, Jean] Univ So Calif, Los Angeles, CA USA. [Wood, Kathy] Cerner Corp, Vienna, VA USA. [Papp, John] NCHHSTP, Lab Reference & Res Branch, Div STD Prevent, Atlanta, GA USA. [Caliendo, Angela M.] Emory Univ, Sch Med, Atlanta, GA USA. [Caliendo, Angela M.] Emory Univ, Ctr AIDS Res, Atlanta, GA 30322 USA. RP Mayer, KH (reprint author), Fenway Hlth, Fenway Inst, Med Res, 1340 Boylston St, Boston, MA 02215 USA. EM Khmayer@gmail.com FU Centers for Disease Control and Prevention [200-2002-00610, 200-2002-00611, 200-2002-00612, 200-2002-00613, 200-2007-23633, 200-2007-23634, 200-2007-23635, 200-2007-23636]; Emory Center for AIDS research [P30 AI050409] FX Supported by Centers for Disease Control and Prevention contracts 200-2002-00610, 200-2002-00611, 200-2002-00612, 200-2002-00613, 200-2007-23633, 200-2007-23634, 200-2007-23635, and 200-2007-23636. This work was supported in part by the Emory Center for AIDS research (P30 AI050409). NR 37 TC 32 Z9 32 U1 1 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JAN PY 2012 VL 39 IS 1 BP 1 EP 7 DI 10.1097/OLQ.0b013e31823b1922 PG 7 WC Infectious Diseases SC Infectious Diseases GA 865DM UT WOS:000298291000002 PM 22183836 ER PT J AU Meites, E Llata, E Hariri, S Zenilman, J Longfellow, L Schwebke, J Tabidze, I Mettenbrink, C Jenkins, H Guerry, S Pathela, P Asbel, L Stover, JA Bernstein, K Kerani, RP Dunne, EF Markowitz, LE AF Meites, Elissa Llata, Eloisa Hariri, Susan Zenilman, Jonathan Longfellow, Lisa Schwebke, Jane Tabidze, Irina Mettenbrink, Christie Jenkins, Heidi Guerry, Sarah Pathela, Preeti Asbel, Lenore Stover, Jeffrey A. Bernstein, Kyle Kerani, Roxanne P. Dunne, Eileen F. Markowitz, Lauri E. TI HPV Vaccine Implementation in STD Clinics-STD Surveillance Network SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID SEXUALLY-TRANSMITTED-DISEASES; UNITED-STATES; PREVENTION; PREVALENCE; SERVICES; CANCERS; US AB We surveyed selected public sexually transmitted disease clinics in the United States regarding human papillomavirus vaccine availability, target populations, funding sources, and barriers. Although nearly all had experience offering other vaccines, only 7 of 42 clinics (17%) offered human papillomavirus vaccine. Vaccine cost, staff time, and follow-up issues were commonly reported barriers. C1 [Meites, Elissa; Llata, Eloisa; Hariri, Susan; Dunne, Eileen F.; Markowitz, Lauri E.] CDC, Div STD Prevent, Atlanta, GA 30333 USA. [Zenilman, Jonathan] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Longfellow, Lisa] Louisiana Dept Hlth & Hosp, Baton Rouge, LA 70821 USA. [Schwebke, Jane] Univ Alabama, Birmingham, AL USA. [Tabidze, Irina] Chicago Dept Publ Hlth, Chicago, IL USA. [Mettenbrink, Christie] Denver Publ Hlth Dept, Denver, CO USA. [Jenkins, Heidi] Connecticut Dept Publ Hlth, Hartford, CT USA. [Guerry, Sarah] Los Angeles Cty Dept Publ Hlth, Los Angeles, CA USA. [Pathela, Preeti] New York City Dept Hlth & Mental Hyg, New York, NY USA. [Asbel, Lenore] Philadelphia Dept Publ Hlth, Philadelphia, PA USA. [Stover, Jeffrey A.] Virginia Dept Hlth, Richmond, VA USA. [Stover, Jeffrey A.] Virginia Commonwealth Univ, Richmond, VA USA. [Bernstein, Kyle] San Francisco Dept Publ Hlth, San Francisco, CA USA. [Kerani, Roxanne P.] Seattle & King Cty, Publ Hlth, Seattle, WA USA. RP Meites, E (reprint author), CDC, Div STD Prevent, 1600 Clifton Rd NE,MS E-02, Atlanta, GA 30333 USA. EM emeites@cdc.gov OI Meites, Elissa/0000-0002-0077-2591 NR 15 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JAN PY 2012 VL 39 IS 1 BP 32 EP 34 DI 10.1097/OLQ.0b013e3182315584 PG 3 WC Infectious Diseases SC Infectious Diseases GA 865DM UT WOS:000298291000009 PM 22183843 ER PT J AU Paz-Bailey, G Fernandez, VI Miranda, SM Jacobson, JO Mendoza, S Paredes, MA Danaval, DC Mabey, D Monterroso, E AF Paz-Bailey, Gabriela Fernandez, Virginia Isern Morales Miranda, Sonia Jacobson, Jerry O. Mendoza, Suyapa Paredes, Mayte A. Danaval, Damien C. Mabey, David Monterroso, Edgar TI Unsafe Sexual Behaviors Among HIV-Positive Men and Women in Honduras: The Role of Discrimination, Condom Access, and Gender SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID ANTIRETROVIRAL TREATMENT; INFECTED PATIENTS; PREVENTION; THERAPY; RISK; TRANSMISSION; INDIVIDUALS; HAART; AIDS AB Background: We conducted a study among HIV-positive men and women in Honduras to describe demographics, HIV risk behaviors and sexually transmitted infection prevalence, and identify correlates of unsafe sex. Methods: Participants were recruited from HIV clinics and nongovernmental organizations in Tegucigalpa and San Pedro Sula, Honduras in a cross-sectional study in 2006. We used audio-assisted computer interviews on demographics; behaviors in the past 12 months, 6 months, and 30 days; and access to care. Assays performed included herpes (HSV-2 Herpes Select), syphilis (rapid plasma reagin [RPR] and Treponema pallidum particle agglutination assay [TPPA]) serology, and other sexually transmitted infections by polymerase chain reaction (PCR). Bivariate and multivariate analyses were conducted to assess variables associated with unprotected sex across all partner types in the past 12 months. Results: Of 810 participants, 400 were from Tegucigalpa and 410 from San Pedro Sula; 367 (45%) were men. Mean age was 37 years (interquartile range: 31-43). Consistent condom use for men and women was below 60% for all partner types. In multivariate analysis, unprotected sex was more likely among women (odds ratio [OR]: 1.9, 95% confidence interval [CI]: 1.2-3.1, P = 0.007), those with HIV diagnoses within the past year (OR: 2.0, 95% CI: 1.1-3.7, P = 0.016), those reporting difficulty accessing condoms (OR: 2.6, 95% CI: 1.44.7, P = 0.003), and those reporting discrimination (OR: 1.8, 95% CI: 1.1-3.0, P = 0.016). Conclusions: Programs targeting HIV-positive patients need to address gender-based disparities, improve condom access and use, and help establish a protective legal and policy environment free of stigma and discrimination. C1 [Paz-Bailey, Gabriela; Morales Miranda, Sonia] Del Univ Valle, Ctr Hlth Studies, Guatemala City, Guatemala. [Paz-Bailey, Gabriela] Tephinet Inc, Atlanta, GA USA. [Fernandez, Virginia Isern; Mabey, David] London Sch Hyg & Trop Med, London WC1, England. [Jacobson, Jerry O.] Pan Amer Hlth Org, Bogota, Colombia. [Mendoza, Suyapa; Paredes, Mayte A.] Minist Hlth, Tegucigalpa, Honduras. [Danaval, Damien C.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA USA. [Monterroso, Edgar] Ctr Dis Control & Prevent, Global AIDS Program, Atlanta, GA USA. RP Paz-Bailey, G (reprint author), 1600 Clifton Rd, Atlanta, GA 30333 USA. EM gmb5@cdc.gov OI Mabey, David/0000-0002-0031-8276 FU United States Agency for International Development office in Honduras; Centers for Disease Control and Prevention; Network for Research and Training in Tropical Diseases in Central America (NeTropica) [06-R-2010] FX Supported by funds from the United States Agency for International Development office in Honduras and the Centers for Disease Control and Prevention and the Network for Research and Training in Tropical Diseases in Central America (NeTropica) under the project No. 06-R-2010. NR 30 TC 5 Z9 5 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JAN PY 2012 VL 39 IS 1 BP 35 EP 41 DI 10.1097/OLQ.0b013e318231cf2d PG 7 WC Infectious Diseases SC Infectious Diseases GA 865DM UT WOS:000298291000010 PM 22183844 ER PT J AU Bradley, H Satterwhite, CL AF Bradley, Heather Satterwhite, Catherine Lindsey TI Prevalence of Neisseria gonorrhoeae Infections Among Men and Women Entering the National Job Training Program-United States, 2004-2009 SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID SEXUALLY-TRANSMITTED INFECTIONS; PUBLIC-HEALTH LABORATORIES; CHLAMYDIA; DISEASES; TESTS AB Background: National notifiable disease data indicate that there were 99 cases of gonorrhea for every 100,000 persons in the United States in 2009, the lowest recorded gonorrhea rate in US history. However, the extent to which declining case reports signify a reduction in prevalence is unknown. Methods: Gonorrhea prevalence was estimated among 16- to 24-year-ld men and women entering the National Job Training Program (NJTP) between 2004 and 2009. Multivariate logistic regression was used to assess the probability of testing positive for gonorrhea over time. Results: A total of 95,184 men and 91,697 women were screened for gonorrhea upon entry to the NJTP between 2004 and 2009. For women, gonorrhea prevalence increased from 2004 (2.6%) to 2006 (2.9%), then decreased steadily through 2009 (1.8%). For men, prevalence increased from 2004 (1.3%) to 2005 (1.6%), then decreased through 2009 (0.9%). Gonorrhea prevalence among black women decreased from 3.6% in 2004 to 2.5% in 2009 and was 2 to 4 times higher than prevalence among white women. Likewise, prevalence among black men decreased from 2.0% to 1.5% and was 8 to 22 times higher than prevalence among white men. After adjusting for gonorrhea risk factors, the odds of women and men testing positive for gonorrhea decreased by 50% and 40%, respectively, from 2004 to 2009. Conclusions: Declining trends in gonorrhea infection among NJTP entrants are similar to those observed in gonorrhea case report data, suggesting that the decrease in case reports is due to a decrease in prevalence. However, targeted interventions are needed to reduce gonorrhea infections in populations with disproportionate risk. C1 [Bradley, Heather; Satterwhite, Catherine Lindsey] Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Bradley, Heather] Ctr Dis Control & Prevent, Div Appl Sci, Epidem Intelligence Serv, Sci Educ & Profess Dev Program Off, Atlanta, GA 30333 USA. RP Bradley, H (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, 1600 Clifton Rd NE,MS E-02, Atlanta, GA 30333 USA. EM iyk5@cdc.gov NR 23 TC 7 Z9 7 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JAN PY 2012 VL 39 IS 1 BP 49 EP 54 DI 10.1097/OLQ.0b013e318231cd5d PG 6 WC Infectious Diseases SC Infectious Diseases GA 865DM UT WOS:000298291000013 PM 22183847 ER PT J AU Schulte, JM Williams, L Asghar, J Dang, T Bedwell, S Guerrero, K Hamaker, D Stonecipher, S Zoretic, J Chow, C AF Schulte, Joann M. Williams, Linda Asghar, Jawaid Dang, Thi Bedwell, Shelby Guerrero, Kenzi Hamaker, Doug Stonecipher, Shelley Zoretic, James Chow, Catherine TI How We Didn't Clean Up Until We Washed Our Hands: Shigellosis in an Elementary and Middle School in North Texas SO SOUTHERN MEDICAL JOURNAL LA English DT Article DE hand washing; school; Shigella; surveillance ID DAY-CARE-CENTERS; RISK-FACTORS; DYSENTERIAE TYPE-1; OUTBREAK; SONNEI; TRANSMISSION; COMMUNITIES; INFECTIONS; CHILDREN; SURVIVAL AB Background: Shigella outbreaks often continue for months and are linked frequently to poor hygiene and hand washing. Such outbreaks are found often in day care facilities, but rarely are reported in schools. We present the investigation of an outbreak in autumn 2007 at a building that housed an elementary school and a middle school in separate wings in a small Texas city north of Dallas-Fort Worth. Methods: We canvassed local hospitals, school attendance records, and physician offices for cases. Ill individuals were interviewed using a standard questionnaire for symptoms, disease onset, and the presence of the illness in an ill person's household. Results: A music teacher was the index case for this outbreak of gastrointestinal illness caused by S. sonnei. Ten percent of the students in the school building were ill, and 15 households had secondary cases. Installing liquid soap in dispensers in student restrooms was the initial control measure, followed by sustained instruction in hand washing, scheduled hand washing times, and monitored cleaning and disinfection procedures for surfaces and inanimate objects. Enhanced surveillance detected no new cases in the school district. Conclusions: Appropriate soap supplies and repeated instruction in hand washing and its monitoring were needed to control the outbreak. C1 [Schulte, Joann M.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. Texas Dept State Hlth Serv, Austin, TX USA. RP Schulte, JM (reprint author), Ctr Dis Control & Prevent, MS E-04,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM jzs1@cdc.gov NR 20 TC 5 Z9 6 U1 2 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0038-4348 EI 1541-8243 J9 SOUTH MED J JI South.Med.J. PD JAN PY 2012 VL 105 IS 1 BP 1 EP 4 DI 10.1097/SMJ.0b013e31823c411e PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 869PC UT WOS:000298609200001 PM 22189658 ER PT J AU Stepanov, I Knezevich, A Zhang, LQ Watson, CH Hatsukami, DK Hecht, SS AF Stepanov, Irina Knezevich, Aleksandar Zhang, Liqin Watson, Clifford H. Hatsukami, Dorothy K. Hecht, Stephen S. TI Carcinogenic tobacco-specific N-nitrosamines in US cigarettes: three decades of remarkable neglect by the tobacco industry SO TOBACCO CONTROL LA English DT Article AB Background Modification of tobacco curing methods and other changes in cigarette manufacturing techniques could substantially reduce the levels of tobacco-specific nitrosamines (TSNA), a group of potent carcinogens, in cigarette smoke. In 1999, two major US cigarette manufacturers stated their intent to move towards using tobaccos low in TSNA. There is no information available on current TSNA levels in tobacco of various cigarettes available in the US, particularly in the newer varieties introduced over the past decade. Methods Seventeen brands of cigarettes were purchased in April of 2010 from retail stores in Minnesota. TSNA levels were measured in the tobacco filler and smoke of these cigarettes. Results In all brands, the sum of two potent carcinogenic TSNA - 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine - in cigarette filler averaged 2.54 (+/- 1.05) mu g/g tobacco. This value is virtually identical to the sum of these two carcinogens reported for the tobacco of a US filtered cigarette in 1979. TSNA levels in smoke positively correlated with those in tobacco filler of the same cigarettes. Conclusion We found no indication that any meaningful attempt was made to reduce or at least control TSNA levels in the new varieties of the popular brands Marlboro and Camel introduced over the last decade. In light of the recently granted regulatory authority to the FDA over tobacco products, regulation of TSNA levels in cigarette tobacco should be strongly considered to reduce the levels of these potent carcinogens in cigarette smoke. C1 [Stepanov, Irina; Knezevich, Aleksandar; Hatsukami, Dorothy K.; Hecht, Stephen S.] Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN 55455 USA. [Stepanov, Irina; Knezevich, Aleksandar; Hatsukami, Dorothy K.; Hecht, Stephen S.] Univ Minnesota, Tobacco Use Res Programs, Minneapolis, MN 55455 USA. [Zhang, Liqin; Watson, Clifford H.] Ctr Dis Control & Prevent, Emergency Response & Air Toxicants Branch, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Stepanov, I (reprint author), Univ Minnesota, Masonic Canc Ctr, 420 Delaware St SE,MMC 806, Minneapolis, MN 55455 USA. EM stepa011@umn.edu OI Stepanov, Irina/0000-0001-5140-8944; Hecht, Stephen/0000-0001-7228-1356 FU National Institutes of Health as part of the Tobacco Harm Reduction Network [P50 DA-13333]; [CA-81301] FX This study was supported by National Institutes of Health grants P50 DA-13333 as part of the Tobacco Harm Reduction Network and CA-81301. NR 29 TC 17 Z9 17 U1 0 U2 5 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0964-4563 J9 TOB CONTROL JI Tob. Control PD JAN PY 2012 VL 21 IS 1 BP 44 EP 48 DI 10.1136/tc.2010.042192 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 866VQ UT WOS:000298414600009 PM 21602537 ER PT J AU Teeguarden, JG Calafat, AM Doerge, DR AF Teeguarden, Justin G. Calafat, Antonia M. Doerge, Daniel R. TI Adhering to Fundamental Principles of Biomonitoring, BPA Pharmacokinetics, and Mass Balance Is No "Flaw" SO TOXICOLOGICAL SCIENCES LA English DT Letter ID BISPHENOL-A BPA; HUMAN EXPOSURE; URINARY CONCENTRATIONS; TOXICITY; MONKEYS; SAMPLES C1 [Teeguarden, Justin G.] Pacific NW Natl Lab, Div Biol Sci, Richland, WA 99352 USA. [Calafat, Antonia M.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30341 USA. [Doerge, Daniel R.] US FDA, Div Biochem Toxicol, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA. RP Teeguarden, JG (reprint author), Pacific NW Natl Lab, Div Biol Sci, 902 Battelle Blvd, Richland, WA 99352 USA. EM justin.teeguarden@pnl.gov NR 26 TC 3 Z9 4 U1 1 U2 7 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 J9 TOXICOL SCI JI Toxicol. Sci. PD JAN PY 2012 VL 125 IS 1 BP 321 EP 325 DI 10.1093/toxsci/kfr275 PG 5 WC Toxicology SC Toxicology GA 871JP UT WOS:000298734400030 ER PT J AU Deng, ZH Zhang, QM Huang, SY Jones, JL AF Deng, Zhuo-Hui Zhang, Qi-Ming Huang, Shao-Yu Jones, Jeffrey L. TI First provincial survey of Angiostrongylus cantonensis in Guangdong Province, China SO TROPICAL MEDICINE & INTERNATIONAL HEALTH LA English DT Article DE Angiostrongylus cantonensis; Pomacea canaliculata; Achatina fulica; rodents; focus; China; Angiostrongylus cantonensis; Pomacea canaliculata; Achatina fulica; rongeurs; foyer; Chine; Angiostrongylus cantonensis; Pomacea canaliculata; Achatina fulica; roedores; foco; China ID RATTUS; CHEN AB The rat lungworm Angiostrongylus cantonensis is a zoonotic nematode with a wide distribution. We report the first provincial survey of the prevalence of A.cantonensis infection among wild rodents and snails in Guangdong Province, China. A total of 2929 Pomacea canaliculata and 1354 Achatina fulica were collected from fields in 22 survey sites with a larval infection rates ranging from 026.6% to 045.4%. In addition, 114 Cipangopaludina sp and 252 Bellamya sp were bought from markets; larvae were found only in Bellamya snails from two survey sites with an infection rate of 1.4% (1/70) and 3.3% (3/91), respectively. Four hundred and ninety-one rodents were captured in nine sites (Rattus norvegicus, R.flavipectus, Suncus murinus, Mus musculus, Bandicota indica, R.losea and R.rattus). Adult worms were found in R.norvegicus, R.flavipectus and Bandicota indica. Our survey revealed a wide distribution of A.cantonensis and its intermediate hosts P.canaliculata and A.fulica in Guangdong. The prevalence of A.cantonensis in wild snails and rats poses a substantial risk for angiostrongyliasis in humans. C1 [Deng, Zhuo-Hui; Zhang, Qi-Ming; Huang, Shao-Yu] Ctr Dis Control & Prevent Guangdong Prov, Inst Parasit Dis, Guangzhou 510300, Guangdong, Peoples R China. [Jones, Jeffrey L.] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA USA. RP Deng, ZH (reprint author), Ctr Dis Control & Prevent Guangdong Prov, Inst Parasit Dis, 176 Xingang Xi Rd, Guangzhou 510300, Guangdong, Peoples R China. EM tracydzh@gmail.com FU Guangdong Medical Science and Technology Research Fund [A2007063] FX We thank the staff from different level CDCs for their dedicated work during this survey. This work was supported by Guangdong Medical Science and Technology Research Fund (No. A2007063). NR 13 TC 7 Z9 9 U1 0 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1360-2276 J9 TROP MED INT HEALTH JI Trop. Med. Int. Health PD JAN PY 2012 VL 17 IS 1 BP 119 EP 122 DI 10.1111/j.1365-3156.2011.02880.x PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 865RO UT WOS:000298328200013 PM 21906215 ER PT J AU Tsai, J Ford, ES Li, CY Zhao, GX AF Tsai, James Ford, Earl S. Li, Chaoyang Zhao, Guixiang TI Past and current alcohol consumption patterns and elevations in serum hepatic enzymes among US adults SO ADDICTIVE BEHAVIORS LA English DT Article DE Alcohol consumption; Former drinkers; Aminotransferase; Alanine aminotransferase (ALT); Aspartate aminotransferase (AST); Gamma-glutamyl transferase (GGT) ID GAMMA-GLUTAMYL-TRANSFERASE; LIVER-DISEASE; UNITED-STATES; PROSPECTIVE COHORT; MORTALITY; DRINKING; RISK; HEALTH; AMINOTRANSFERASE; FREQUENCY AB Objective: The aim of this study was to examine the association between patterns of past and current alcohol consumption and elevations in serum hepatic enzymes among a nationally representative sample of adults in the United States. Methods: We estimated the age-adjusted prevalence of elevated serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT) among 8993 adults aged 20 years or older who participated in the 2005-2008 National Health and Nutrition Examination Survey (NHANES). We produced prevalence ratios by using patterns of alcohol consumption as a predictor: elevations in serum ALT. AST, and GGT were used as an outcome variable while adjusting for covariates in multivariate regression models. Results: The age-adjusted prevalence of elevated serum ALT, AST, and GGT in adults was 9.7%, 16.0%, and 8.6%, respectively. Male excessive current drinkers had 50%-71% and 75%-314% increased likelihoods of having elevated serum AST and GGT, respectively: female excessive drinkers with a history of consuming 5 or more drinks almost daily had a 226% increased likelihood of having elevated serum GGT, when compared to their respective counterparts who were lifetime abstainers. Conclusions: The results of this study indicate that elevations in serum hepatic enzymes, especially AST and GGT, are common in adults who are excessive current drinkers. There is evidence to suggest that excessive current drinkers with a history of protracted drinking are especially vulnerable to potential liver injury. These findings lend further support to the early identification of excessive drinkers who may have an increased risk for alcohol-related morbidity and mortality in health care settings. Published by Elsevier Ltd. C1 [Tsai, James; Ford, Earl S.; Li, Chaoyang; Zhao, Guixiang] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Tsai, J (reprint author), Ctr Dis Control & Prevent CDC, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway,Mail Stop K67, Atlanta, GA 30341 USA. EM jxt9@cdc.gov NR 54 TC 23 Z9 27 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4603 J9 ADDICT BEHAV JI Addict. Behav. PD JAN PY 2012 VL 37 IS 1 BP 78 EP 84 DI 10.1016/j.addbeh.2011.09.002 PG 7 WC Psychology, Clinical; Substance Abuse SC Psychology; Substance Abuse GA 854ZG UT WOS:000297532700011 PM 21975024 ER PT J AU Okoro, CA Zhao, GX Li, CY Balluz, LS AF Okoro, Catherine A. Zhao, Guixiang Li, Chaoyang Balluz, Lina S. TI Use of complementary and alternative medicine among US adults with and without functional limitations SO DISABILITY AND REHABILITATION LA English DT Article DE complementary medicine; alternative medicine; alternative therapy; USA; functional outcomes ID HEALTH INTERVIEW SURVEY; UNITED-STATES; PHYSICAL-DISABILITIES; OLDER-ADULTS; CARE; THERAPIES; REHABILITATION; INDIVIDUALS; SURVIVORS; CANCERS AB Purpose. This study characterizes the use of complementary and alternative medicine (CAM) among adults with and without functional limitations. We also examine the reasons for using CAM and for disclosing its use to conventional medical professionals. Methods. Data were obtained from the 2007 adult CAM supplement and components of the National Health Interview Survey (n = 20,710). Results. Adults with functional limitations used CAM more frequently than those without (48.7% vs. 35.4%; p < 0.001). Adults with functional limitations used mind-body therapies the most (27.4%) and alternative medical systems the least (4.8%). Relaxation techniques were the most common therapy used by adults with functional limitations, and they used it more often than those without limitations (24.6% vs. 13.7%; P < 0.001). More than half of the adults with functional limitations (51.3%) discussed CAM use with conventional medical professionals, compared with 37.9% of adults without limitations (p < 0.001). The main reason for CAM use was general wellness/disease prevention among adults with and without functional limitations (59.8% vs. 63.1%; P = 0.051). Conclusions. CAM use among adults with functional limitations is high. Health practitioners should screen for and discuss the safety and efficacy of CAM when providing health care. C1 [Okoro, Catherine A.; Li, Chaoyang; Balluz, Lina S.] Ctr Dis Control & Prevent CDC, Off Surveillance Epidemiol & Lab Serv, Publ Hlth Surveillance Program Off, Div Behav Surveillance, Atlanta, GA USA. [Zhao, Guixiang] CDC, Off Noncommunicable Dis Injury & Environm Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Adult & Community Hlth, Atlanta, GA 30333 USA. RP Okoro, CA (reprint author), Ctr Dis Control & Prevent, Div Behav Surveillance, Publ Hlth Surveillance Program Off, Off Surveillance Epidemiol & Lab Serv, 1600 Clifton Rd NE,M-S E-97, Atlanta, GA 30333 USA. EM COkoro@cdc.gov NR 44 TC 11 Z9 11 U1 3 U2 8 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0963-8288 J9 DISABIL REHABIL JI Disabil. Rehabil. PY 2012 VL 34 IS 2 BP 128 EP 135 DI 10.3109/09638288.2011.591887 PG 8 WC Rehabilitation SC Rehabilitation GA 855UR UT WOS:000297591400005 PM 21962229 ER PT J AU Smith, GJD Donis, RO AF Smith, Gavin J. D. Donis, Ruben O. CA WHO OIE FAO H5N1 Evolution Working TI Continued evolution of highly pathogenic avian influenza A (H5N1): updated nomenclature SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article DE H5N1; hemagglutinin; highly pathogenic avian influenza; molecular epidemiology; nomenclature; phylogenetics; viral evolution ID VIRUSES; POULTRY; VIETNAM AB Background Continued evolution of highly pathogenic avian influenza A (H5N1) throughout many regions of the eastern hemisphere has led to the emergence of new phylogenetic groups. A total of 1637 new H5N1 hemagglutinin (HA) sequences have become available since the previous nomenclature recommendations described in 2009 by the WHO/OIE/FAO H5N1 Evolution Working Group. A comprehensive analysis including all the new data is needed to update HA clade nomenclature. Methods Phylogenetic trees were constructed from data sets of all available H5N1 HA sequences. New clades were designated on the basis of phylogeny and p-distance using the preestablished nomenclature system (Emerg Infec Dis 2008; 14:e1). Each circulating H5N1 clade was subjected to further phylogenetic analysis and nucleotide sequence divergence calculations. Results All recently circulating clades (clade 1 in the Mekong River Delta, 2.1.3 in Indonesia, 2.2 in India/Bangladesh, 2.2.1 in Egypt, 2.3.2, 2.3.4 and 7 in Asia) required assignment of divergent HA genes to new second-, third-, and/or fourth-order clades. At the same time, clades 0, 3, 4, 5, 6, 8, 9, and several second- and third- order groups from clade 2 have not been detected since 2008 or earlier. Conclusions New designations are recommended for 12 HA clades, named according to previously defined criteria. In addition, viruses from 13 clades have not been detected since 2008 or earlier. The periodic updating of this dynamic classification system allows continued use of a unified nomenclature in all H5N1 studies. C1 [Smith, Gavin J. D.] Duke NUS Grad Med Sch, Program Emerging Infect Dis, Singapore 169857, Singapore. [Donis, Ruben O.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA. RP Smith, GJD (reprint author), Duke NUS Grad Med Sch, Program Emerging Infect Dis, Singapore 169857, Singapore. EM gavin.smith@duke-nus.edu.sg; rdonis@cdc.gov OI Bahl, Justin/0000-0001-7572-4300; Smith, Gavin JD/0000-0001-5031-468X FU Australian Government Department of Health and Ageing FX We thank Justin Bahl, Ian H. Brown, Giovanni Cattoli, Todd Davis, Ruben O. Donis, Ron A.M. Fouchier, Elizabeth Mumford, Pierre Rivailler, Gavin J.D. Smith, and Ian A. York for drafting the manuscript on behalf of the H5N1 Evolution Working Group. We also thank Justin Bahl, Todd Davis, Pierre Rivailler, and Gavin Smith for performing sequence and phylogenetic analyses. We acknowledge access to sequence information from the GISAID database. The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health and Ageing. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. This publication contains the collective views of an international group of experts and does not necessarily represent the decisions or the stated policy of the Food and Agriculture Organization of the United Nations (FAO), the World Organisation for Animal Health (OIE), or the World Health Organization (WHO). NR 14 TC 98 Z9 98 U1 1 U2 22 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1750-2640 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD JAN PY 2012 VL 6 IS 1 BP 1 EP 5 DI 10.1111/j.1750-2659.2011.00298.x PG 5 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 861JK UT WOS:000298015000001 ER PT J AU Ortiz, JR Lafond, KE Wong, TA Uyeki, TM AF Ortiz, Justin R. Lafond, Kathryn E. Wong, Tiffany A. Uyeki, Timothy M. TI Pandemic influenza in Africa, lessons learned from 1968: a systematic review of the literature SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Review DE Africa; influenza; pandemic ID HONG-KONG INFLUENZA; RESPIRATORY-TRACT INFECTIONS; VIRAL ANTIBODIES; CHILDREN; VIRUS; PREPAREDNESS; PNEUMONIA; MORTALITY; ETIOLOGY; INFANTS AB Background To help understand the potential impact of the 2009 H1N1 pandemic in Africa, we reviewed published data from Africa of the two previous influenza pandemics. Methods We conducted a systematic search of three biomedical databases for articles in any language on 1957 H2N2 or 1968 H3N2 pandemic influenza virus infection in Africa published from January 1950 through August 2008. Results We identified 1327 potentially relevant articles, and 298 warranted further review. Fourteen studies on 1968 H3N2 influenza met inclusion criteria, while two studies identified describing 1957 H2N2 were excluded for data limitations. Among these 14 studies, community attack rates for symptomatic infection during all 1968 pandemic waves were around 20%. However, the proportion infected in communities ranged from 6% in isolated communities to 100% in enclosed populations. A total of 22-64% of sampled clinic patients and 8-72% of hospitalized patients had evidence of 1968 H3N2 virus infection. After the second pandemic wave, up to 41-75% of persons tested had serological evidence of 1968 H3N2 virus infection. Conclusion The 1968 H3N2 influenza pandemic, generally regarded as mild worldwide, appears to have had a substantial impact upon public health in Africa. Without more epidemiologic data the impact of the 2009 H1N1 pandemic in Africa cannot be assumed to have been mild. Assessment of the burden of 2009 H1N1 virus and future influenza pandemics in Africa should attempt to assess disease impact by a variety of methods, including substudies among specific populations. C1 [Ortiz, Justin R.] Univ Washington, Int Resp & Severe Illness Ctr INTERSECT, Div Pulm & Crit Care Med, Dept Med,Med Ctr, Seattle, WA 98195 USA. [Lafond, Kathryn E.; Uyeki, Timothy M.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. [Wong, Tiffany A.] Univ San Francisco, Masagung Grad Sch Management, San Francisco, CA 94117 USA. RP Ortiz, JR (reprint author), Univ Washington, Int Resp & Severe Illness Ctr INTERSECT, Div Pulm & Crit Care Med, Dept Med,Med Ctr, Box 356522,1959 NE Pacific St, Seattle, WA 98195 USA. EM jrortiz@u.washington.edu FU NHLBI [HL007287]; Robert Wood Johnson Harold Amos Medical Faculty [67423] FX JRO reports receiving research funding from NHLBI Respiratory Research Training Grant [HL007287]] and Robert Wood Johnson Harold Amos Medical Faculty Development Program (Grant 67423). The remaining authors (KEL, TAW, TMU) received no specific funding. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 51 TC 6 Z9 6 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1750-2640 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD JAN PY 2012 VL 6 IS 1 BP 11 EP 24 DI 10.1111/j.1750-2659.2011.00257.x PG 14 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 861JK UT WOS:000298015000003 PM 21668669 ER PT J AU Irving, SA Patel, DC Kieke, BA Donahue, JG Vandermause, MF Shay, DK Belongia, EA AF Irving, Stephanie A. Patel, Darshan C. Kieke, Burney A. Donahue, James G. Vandermause, Mary F. Shay, David K. Belongia, Edward A. TI Comparison of clinical features and outcomes of medically attended influenza A and influenza B in a defined population over four seasons: 2004-2005 through 2007-2008 SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article DE Influenza A; influenza B; comparison ID UNITED-STATES; NASOPHARYNGEAL ASPIRATE; VIRUS-INFECTIONS; NASAL SWAB; MORTALITY; EPIDEMICS; CHILDREN; HOSPITALIZATIONS; SPECIMENS; TECUMSEH AB Background There are few prospectively collected data comparing illnesses caused by different subtypes of influenza. We compared the clinical presentation and outcomes of subjects with primarily outpatient-attended influenza A and B infections during four consecutive influenza seasons (2004-2005 through 2007-2008). Methods Patients were prospectively enrolled and tested for influenza following an encounter for acute respiratory illness. Influenza infections were confirmed by culture or reverse transcription polymerase chain reaction; subtype was determined for a sample of influenza A isolates each season. Clinical characteristics of influenza A and B infections were compared across and within individual seasons. Results We identified 901 cases of influenza A and 284 cases of influenza B; 98% of cases were identified through an outpatient medical encounter. Thirty-six percent of patients with each strain had received seasonal influenza vaccine prior to illness onset. There were no consistent differences in symptoms associated with influenza A and B. Influenza A infection was associated with earlier care seeking compared with influenza B during the 2005-2006 and 2007-2008 seasons, when H3N2 was the dominant type A virus, and in a combined analysis that included all seasons. Twenty-six (2.2%) of 1185 cases were diagnosed with radiographically confirmed pneumonia, and 59 (5%) of 1185 patients were hospitalized within 30 days of illness onset. Conclusions Over four influenza seasons, aside from shorter intervals from illness onset to clinical encounter for infections with the A(H3N2) subtype, clinical symptoms and outcomes were similar for patients with predominantly outpatient-attended influenza A and B infections. C1 [Irving, Stephanie A.; Patel, Darshan C.; Kieke, Burney A.; Donahue, James G.; Vandermause, Mary F.; Belongia, Edward A.] Marshfield Clin Res Fdn, Marshfield, WI USA. [Shay, David K.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. RP Irving, SA (reprint author), Marshfield Clin Res Fdn ML2, 1000 N Oak Ave, Marshfield, WI 54449 USA. EM irving.stephanie@marshfieldclinic.org OI Irving, Stephanie/0000-0001-7437-6797; Shay, David/0000-0001-9619-4820; Patel, Darshan/0000-0002-2236-7757 FU Centers for Disease Control and Prevention, Atlanta, GA [1 U01 CI000192-01] FX Funding for this research was provided by a cooperative agreement with the Centers for Disease Control and Prevention, Atlanta, GA. (1 U01 CI000192-01). The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 29 TC 31 Z9 31 U1 1 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1750-2640 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD JAN PY 2012 VL 6 IS 1 BP 37 EP 43 DI 10.1111/j.1750-2659.2011.00263.x PG 7 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 861JK UT WOS:000298015000006 PM 21668663 ER PT J AU Burco, JD Etienne, KA Massey, JG Ziccardi, MH Balajee, SA AF Burco, Julia D. Etienne, Kizee A. Massey, J. Gregory Ziccardi, Michael H. Balajee, S. Arunmozhi TI Molecular sub-typing suggests that the environment of rehabilitation centers may be a potential source of Aspergillus fumigatus infecting rehabilitating seabirds SO MEDICAL MYCOLOGY LA English DT Article DE Aspergillosis; avian; genotyping; microsatellite analysis; seabirds; A. fumigatus ID MICROSATELLITE MARKERS; TURKEYS; MORTALITY AB Aspergillosis remains a major cause of infection-related avian mortality in birds that are debilitated and undergoing rehabilitation for release into the wild. This study was designed to understand the source of avian aspergillosis in seabirds undergoing rehabilitation at selected northern California aquatic bird rehabilitation centers. Air, surface and water sampling was performed between August 2007 and July 2008 in three such centers and selected natural seabird loafing sites. Average air Aspergillus fumigatus counts were at least nine times higher in samples obtained from the rehabilitation sites (M = 7.34, SD = 9.78 CFU/m(3)), when compared to those found at natural sites (M = 0.76, SD = 2.24 CFU/m(3)), t (205) = -5.99, P < 0.001. A total of 37 A. fumigatus isolates from birds with confirmed aspergillosis and 42 isolates from environmental samples were identified using both morphological and molecular methods, and subsequently sub-typed using an eight-locus microsatellite panel with the neighbor joining algorithm. Results of the study demonstrated the presence of five clonal groups, 13 genotypically related clusters, and 59 distinct genotypes. Six of the 13 genotypically related clusters contained matching genotypes between clinical isolates and local environmental isolates from the rehabilitation center in which these birds were housed. We present evidence that the environment of rehabilitation centers may be a source for A. fumigatus infection in rehabilitated seabirds. C1 [Etienne, Kizee A.; Balajee, S. Arunmozhi] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA 30333 USA. [Burco, Julia D.; Massey, J. Gregory; Ziccardi, Michael H.] Univ Calif Davis, Sch Vet Med, Wildlife Hlth Ctr, Davis, CA 95616 USA. RP Balajee, SA (reprint author), Ctr Dis Control & Prevent, Mycot Dis Branch, 1600 Clifton Rd,Mailstop G-11, Atlanta, GA 30333 USA. EM fir3@cdc.gov FU California Department of Fish and Game's Oil Spill Response Trust through Oiled Wildlife Care Network at the Wildlife Health Center, School of Veterinary Medicine, University of California, Davis FX This project was supported by the California Department of Fish and Game's Oil Spill Response Trust Fund through the Oiled Wildlife Care Network at the Wildlife Health Center, School of Veterinary Medicine, University of California, Davis. We offer a special thanks to the Gulf of the Farallones National Marine Sanctuary for access to sampling sites around Southeast Farallon Island, and the staff and volunteers at each of the various rehabilitation centers. Additional mycology identification assistance provided by Anita Moore and Barbara Byrne from the UC Davis microbiology laboratory. Dr David Stevens from Stanford University and Lisa Tell from UC Davis were also instrumental in facilitating the collaboration between UC Davis and the CDC. NR 28 TC 7 Z9 7 U1 1 U2 12 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1369-3786 J9 MED MYCOL JI Med. Mycol. PD JAN PY 2012 VL 50 IS 1 BP 91 EP 98 DI 10.3109/13693786.2011.592860 PG 8 WC Infectious Diseases; Mycology; Veterinary Sciences SC Infectious Diseases; Mycology; Veterinary Sciences GA 862OU UT WOS:000298103400012 PM 21756021 ER PT S AU Gage, KL AF Gage, Kenneth L. BE DeAlmeida, AMP Leal, NC TI Factors Affecting the Spread and Maintenance of Plague SO ADVANCES IN YERSINIA RESEARCH SE Advances in Experimental Medicine and Biology LA English DT Article; Proceedings Paper CT 10th International Symposium on Yersinia CY OCT 23-27, 2010 CL Recife, BRAZIL ID EARLY-PHASE TRANSMISSION; TAILED PRAIRIE DOGS; FLEA SPECIES SIPHONAPTERA; YERSINIA-PESTIS; XENOPSYLLA-CHEOPIS; UNITED-STATES; BORNE TRANSMISSION; PASTEURELLA-PESTIS; VECTOR COMPETENCE; UNBLOCKED FLEAS C1 Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. RP Gage, KL (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, 3150 Rampart Rd, Ft Collins, CO 80521 USA. EM klg0@cdc.gov NR 92 TC 3 Z9 4 U1 1 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 0065-2598 BN 978-1-4614-3560-0; 978-1-4614-3561-7 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2012 VL 954 BP 79 EP 94 DI 10.1007/978-1-4614-3561-7_11 PG 16 WC Biochemistry & Molecular Biology; Medicine, Research & Experimental; Microbiology SC Biochemistry & Molecular Biology; Research & Experimental Medicine; Microbiology GA BA2DD UT WOS:000333327900012 PM 22782750 ER PT B AU Kohlstadt, I AF Kohlstadt, Ingrid BE Kohlstadt, I TI Advancing Medicine with Food and Nutrients Second Edition Preface SO ADVANCING MEDICINE WITH FOOD AND NUTRIENTS, 2ND EDITION LA English DT Editorial Material; Book Chapter C1 [Kohlstadt, Ingrid] Amer Coll Prevent Med, Washington, DC USA. [Kohlstadt, Ingrid] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Kohlstadt, Ingrid] Johns Hopkins, Baltimore, MD USA. [Kohlstadt, Ingrid] Ctr Dis Control & Prevent, Atlanta, GA USA. [Kohlstadt, Ingrid] Indian Hlth Serv, Hyderabad, Andhra Pradesh, India. [Kohlstadt, Ingrid] Florida Orthoped Inst, Valrico, FL USA. [Kohlstadt, Ingrid] Johns Hopkins Weight Management Ctr, Baltimore, MD USA. [Kohlstadt, Ingrid] US FDA, Rockville, MD 20857 USA. [Kohlstadt, Ingrid] USDA, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-8774-5; 978-1-4398-8772-1 PY 2012 BP XIII EP XIV D2 10.1201/b13694 PG 2 WC Integrative & Complementary Medicine; Nutrition & Dietetics SC Integrative & Complementary Medicine; Nutrition & Dietetics GA BC5HE UT WOS:000353284300001 ER PT J AU Teo, CG AF Teo, Chong Gee TI Changing strategies for hepatitis C testing SO ANTIVIRAL THERAPY LA English DT Editorial Material AB Recent approvals of direct-acting, orally delivered pharmaceuticals for the treatment of patients with infection by HCV and of a point-of-care assay for community screening of HCV infection have generated impetus to widen the identification of HCV-infected individuals. Diagnosis of HCV infection is, however, still based on the detection of anti-HCV immunoglobulin G. As treatment is intended for individuals with current infection, testing for evidence of infection would need to centre on the detection of HCV viraemia. Minimizing the complexity and costs associated with HCV nucleic acid testing and speeding the development and validation of HCV antigen assays expedite the identification of HCV-viraemic individuals. Establishing means to diagnose recent HCV infection and to engage in surveillance of drug-resistant HCV are also apposite. Successful implementation of these various measures brightens prospects for the eventual elimination of HCV. C1 Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30329 USA. RP Teo, CG (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30329 USA. EM enz0@cdc.gov NR 25 TC 2 Z9 2 U1 0 U2 1 PU INT MEDICAL PRESS LTD PI LONDON PA 2-4 IDOL LANE, LONDON EC3R 5DD, ENGLAND SN 1359-6535 J9 ANTIVIR THER JI Antivir. Ther. PY 2012 VL 17 IS 7 BP 1391 EP 1395 DI 10.3851/IMP2468 PN B PG 5 WC Infectious Diseases; Pharmacology & Pharmacy; Virology SC Infectious Diseases; Pharmacology & Pharmacy; Virology GA V30ZG UT WOS:000208853300001 PM 23322655 ER PT J AU Ward, JW AF Ward, John W. TI Testing for HCV: the first step in preventing disease transmission and improving health outcomes for HCV-infected individuals SO ANTIVIRAL THERAPY LA English DT Review AB In the US, application of antibody-based and nucleic acid testing for HCV has dramatically reduced HCV transmissions over the past two decades. In addition to testing donors of blood, tissue and organs to reduce the risk of transfusion/transplantation-associated HCV, testing can also motivate individuals to adopt safer behaviours. HCV testing, when accompanied by appropriate care and treatment, can reduce the extent of morbidity and mortality that often accompanies chronic HCV infection. Options for HCV treatment have recently been expanded and improved with the availability of more effective, anti-HCV drugs; furthermore, the remarkable results of clinical trials of these drugs suggest that safe, all-oral therapies requiring relatively short duration are on the immediate horizon. These advances have prompted new US initiatives to recommend HCV testing to the wider community (including those populations with a high prevalence of hepatitis C) and promote linkage to treatment for those found to be HCV-infected. Crucial to the success of these initiatives are the development of tests capable of identifying active infection, recent infection, or both, and the implementation of testing strategies that facilitate broad access to HCV testing linked to care and treatment. C1 Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30329 USA. RP Ward, JW (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30329 USA. EM jww4@cdc.gov NR 32 TC 6 Z9 6 U1 1 U2 3 PU INT MEDICAL PRESS LTD PI LONDON PA 2-4 IDOL LANE, LONDON EC3R 5DD, ENGLAND SN 1359-6535 J9 ANTIVIR THER JI Antivir. Ther. PY 2012 VL 17 IS 7 BP 1397 EP 1401 DI 10.3851/IMP2477 PN B PG 5 WC Infectious Diseases; Pharmacology & Pharmacy; Virology SC Infectious Diseases; Pharmacology & Pharmacy; Virology GA V30ZG UT WOS:000208853300002 PM 23321543 ER PT J AU Smith, BD Jewett, A Drobeniuc, J Kamili, S AF Smith, Bryce D. Jewett, Amy Drobeniuc, Jan Kamili, Saleem TI Rapid diagnostic HCV antibody assays SO ANTIVIRAL THERAPY LA English DT Review AB Approximately 4.1 million Americans have been infected with HCV and 45-85% of chronically infected persons are unaware of their status. Rapid anti-HCV assays can assist and expedite the identification of those unaware of their infection. Performance characteristics of pre-market rapid anti-HCV assays (Chembio, MedMira and OraSure) have been evaluated. Their sensitivity (78.9-99.3%) and specificity (80-100%) varied. Future investigations could include evaluation of rapid anti-HCV tests in persons who are coinfected with HCV and HIV, and development of rapid HCV-antigen tests and nucleic acid tests. C1 [Smith, Bryce D.; Jewett, Amy; Drobeniuc, Jan; Kamili, Saleem] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30329 USA. RP Smith, BD (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30329 USA. EM bli1@cdc.gov NR 36 TC 3 Z9 3 U1 1 U2 1 PU INT MEDICAL PRESS LTD PI LONDON PA 2-4 IDOL LANE, LONDON EC3R 5DD, ENGLAND SN 1359-6535 J9 ANTIVIR THER JI Antivir. Ther. PY 2012 VL 17 IS 7 BP 1409 EP 1413 PN B PG 5 WC Infectious Diseases; Pharmacology & Pharmacy; Virology SC Infectious Diseases; Pharmacology & Pharmacy; Virology GA V30ZG UT WOS:000208853300004 PM 23322678 ER PT J AU Araujo, AC AF Araujo, Aufra C. TI Antibody- and genome-based identification of recent HCV infection SO ANTIVIRAL THERAPY LA English DT Review AB The diagnosis of recent HCV infection remains challenging due to the absence of serological markers specific to the early phase of infection. Clinical follow-up and seroconversion to anti-HCV immunoglobulin (Ig)G, detection of viral RNA and changes in levels of blood biomarkers associated with liver pathology provide circumstantial evidence of recent HCV infection. Studies based on anti-HCV IgG avidity, antigen-specific antibody profiling, HCV viral load fluctuations and signature changes in the HCV genome show potential to discriminate recent from persistent HCV infection. These markers require further evaluation and would necessitate use of samples from infected people originating from broad clinical and epidemiological contexts. C1 Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30329 USA. RP Araujo, AC (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30329 USA. EM AAraujo@cdc.gov NR 50 TC 4 Z9 4 U1 0 U2 0 PU INT MEDICAL PRESS LTD PI LONDON PA 2-4 IDOL LANE, LONDON EC3R 5DD, ENGLAND SN 1359-6535 J9 ANTIVIR THER JI Antivir. Ther. PY 2012 VL 17 IS 7 BP 1459 EP 1464 DI 10.3851/IMP2464 PN B PG 6 WC Infectious Diseases; Pharmacology & Pharmacy; Virology SC Infectious Diseases; Pharmacology & Pharmacy; Virology GA V30ZG UT WOS:000208853300012 PM 23322615 ER PT J AU Khudyakov, Y AF Khudyakov, Yury TI Molecular surveillance of hepatitis C SO ANTIVIRAL THERAPY LA English DT Review AB With public health focusing on reduction of morbidity and mortality in the human population, transmission and virulence are major targets of molecular disease surveillance. Current molecular approaches to the detection of HCV transmission are based on phylogenetic analysis of intra-host HCV variants. Next-generation sequencing and mass spectrometry offer significant improvements in accuracy, throughput and cost of the transmission identification. Resistance to interferon (IFN) is an important virulence factor as it is essential for establishment of HCV infection and development of disease. IFN resistance has been shown to be associated quantitatively with epistatic connectivity among sites in the HCV genome, thus paving the way for genetic detection of virulence. Integration of genetic testing with computational models that automatically interpret the complex genetic parameters into transmission events and virulence is fundamental to comprehensive molecular surveillance of hepatitis C. C1 Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30329 USA. RP Khudyakov, Y (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30329 USA. EM yek0@cdc.gov NR 67 TC 6 Z9 7 U1 0 U2 0 PU INT MEDICAL PRESS LTD PI LONDON PA 2-4 IDOL LANE, LONDON EC3R 5DD, ENGLAND SN 1359-6535 J9 ANTIVIR THER JI Antivir. Ther. PY 2012 VL 17 IS 7 BP 1465 EP 1470 DI 10.3851/IMP2476 PN B PG 6 WC Infectious Diseases; Pharmacology & Pharmacy; Virology SC Infectious Diseases; Pharmacology & Pharmacy; Virology GA V30ZG UT WOS:000208853300013 PM 23321496 ER PT J AU Lara, J Khudyakov, Y AF Lara, James Khudyakov, Yury TI Epistatic connectivity among HCV genomic sites as a genetic marker of interferon resistance SO ANTIVIRAL THERAPY LA English DT Review AB Until recently, the standard-of-care therapy of patients with HCV infection involves treatment with interferon (IFN) and ribavirin (RBV). Host demographic and genetic factors as well as HCV genetic heterogeneity have been shown to be associated with outcomes of therapy. Although resistance to IFN/RBV remains an important clinical and public health problem, there are no reliable genetic markers for the prediction of the therapy outcomes. Recently, it was shown that adaptation to IFN, a major constituent of the host innate immunity, is reflected in the HCV genetic composition and epistatic connectivity among polymorphic genomic sites, thus providing novel genetic markers of IFN resistance. Consideration of coordinated evolution among HCV genomic sites allows for identification of these genetic markers from short regions of the HCV genome and for accurate prediction of therapeutic outcomes. HCV genomic co-evolution offers a general framework for the detection of predisposition to IFN resistance, and possibly to resistance to direct-acting antivirals. C1 [Lara, James; Khudyakov, Yury] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30329 USA. RP Lara, J (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30329 USA. EM jlara@cdc.gov NR 49 TC 4 Z9 4 U1 0 U2 0 PU INT MEDICAL PRESS LTD PI LONDON PA 2-4 IDOL LANE, LONDON EC3R 5DD, ENGLAND SN 1359-6535 J9 ANTIVIR THER JI Antivir. Ther. PY 2012 VL 17 IS 7 BP 1471 EP 1475 DI 10.3851/IMP2478 PN B PG 5 WC Infectious Diseases; Pharmacology & Pharmacy; Virology SC Infectious Diseases; Pharmacology & Pharmacy; Virology GA V30ZG UT WOS:000208853300014 PM 23321567 ER PT J AU Ganova-Raeva, LM Dimitrova, ZE Campo, DS Khudyakov, Y AF Ganova-Raeva, Lilia M. Dimitrova, Zoya E. Campo, David S. Khudyakov, Yury TI Application of mass spectrometry to molecular surveillance of hepatitis B and C viral infections SO ANTIVIRAL THERAPY LA English DT Review AB Detection of genotypes and drug resistance mutations are important molecular tools assisting in clinical management of patients with chronic hepatitis B and C. Together with methods for assessment of genetic heterogeneity and relatedness of viral strains, they form the foundation of molecular surveillance. Currently, all these methods are based mainly on DNA sequencing followed by phylogenetic analysis. Mass spectrometry (MS) emerged recently as a rapid, cost-effective, reproducible and accurate alternative approach. MS-based molecular assays are highly amenable to automation and provide a suitable platform for routine application to the surveillance of HBV and HCV infections. C1 [Ganova-Raeva, Lilia M.; Dimitrova, Zoya E.; Campo, David S.; Khudyakov, Yury] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30329 USA. RP Ganova-Raeva, LM (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30329 USA. EM LGanova-Raeva@cdc.gov RI Campo, David S./C-5072-2011 OI Campo, David S./0000-0002-8970-3436 NR 65 TC 7 Z9 7 U1 0 U2 0 PU INT MEDICAL PRESS LTD PI LONDON PA 2-4 IDOL LANE, LONDON EC3R 5DD, ENGLAND SN 1359-6535 J9 ANTIVIR THER JI Antivir. Ther. PY 2012 VL 17 IS 7 BP 1477 EP 1482 DI 10.3851/IMP2466 PN B PG 6 WC Infectious Diseases; Pharmacology & Pharmacy; Virology SC Infectious Diseases; Pharmacology & Pharmacy; Virology GA V30ZG UT WOS:000208853300015 PM 23322623 ER PT J AU Stefaniak, AB Virji, MA Day, GA AF Stefaniak, Aleksandr B. Virji, M. Abbas Day, Gregory A. TI Release of Beryllium Into Artificial Airway Epithelial Lining Fluid SO ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH LA English DT Article DE beryllium; dissolution; respiratory tract; sensitization ID AEROSOLS; DISEASE; OXIDE; RISK; SENSITIZATION; PARTICLES; METAL; INHALATION; TOXICITY; FACILITY AB Inhaled beryllium particles that deposit in the lung airway lining fluid may dissolve and interact with immune-competent cells resulting in sensitization. As such, solubilization of 17 beryllium-containing materials (ore, hydroxide, metal, oxide, alloys, and process intermediates) was investigated using artificial human airway epithelial lining fluid. The maximum beryllium release in 7 days was 11.78% (from a beryl ore melter dust), although release from most materials was < 1%. Calculated dissolution half-times ranged from 30 days (reduction furnace material) to 74,000 days (hydroxide). Despite rapid mechanical clearance, billions of beryllium ions may be released in the respiratory tract via dissolution in airway lining fluid. Beryllium-containing particles that deposit in the respiratory tract dissolve in artificial lung epithelial lining fluid, thereby providing ions for absorption in the lung and interaction with immune-competent cells in the respiratory tract. C1 [Stefaniak, Aleksandr B.; Virji, M. Abbas; Day, Gregory A.] NIOSH, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. RP Stefaniak, AB (reprint author), NIOSH, Ctr Dis Control & Prevent, Mailstop H-2800, Morgantown, WV 26505 USA. EM AStefaniak@cdc.gov NR 29 TC 2 Z9 2 U1 0 U2 7 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1933-8244 EI 2154-4700 J9 ARCH ENVIRON OCCUP H JI Arch. Environ. Occup. Health PY 2012 VL 67 IS 4 BP 219 EP 228 DI 10.1080/19338244.2011.619218 PG 10 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 024UV UT WOS:000310135600005 PM 23074979 ER PT J AU Armbruster, CR Forster, TS Donlan, RM O'Connell, HA Shams, AM Williams, MM AF Armbruster, Catherine R. Forster, Terri S. Donlan, Rodney M. O'Connell, Heather A. Shams, Alicia M. Williams, Margaret M. TI A biofilm model developed to investigate survival and disinfection of Mycobacterium mucogenicum in potable water SO BIOFOULING LA English DT Article DE water distribution system biofilm; Mycobacterium mucogenicum; monochloramine; nontuberculous mycobacteria AB Water in healthcare environments can be a source for healthcare-associated infections (HAI). However, information on the exposure risk to opportunistic pathogens in potable water distribution systems (PWDS) is lacking. Laboratory studies characterizing the interaction of opportunistic pathogens with biofilms are needed to understand their role in water systems within healthcare facilities. A stable, repeatable, PWDS multi-species biofilm model comprising Sphingomonas paucimobilis, Methylobacterium sp., Delftia acidovorans, and Mycobacterium mucogenicum was developed in the CDC Biofilm Reactor (CBR), reaching 6 log(10) CFU cm(-2) within 6 days. The model was used to investigate the interaction of the opportunistic pathogen M. mucogenicum with the other species, and to determine the efficacy of monochloramine (NH2Cl) as a disinfectant against 2-week-old biofilms. Addition of 1 or 2 mg l(-1) NH2Cl resulted in the same or an increased log density of viable M. mucogenicum in the biofilm while inactivating some of the Proteobacteria. Although M. mucogenicum preferentially resided in the biofilm, NH2Cl exposure caused release of viable M. mucogenicum from the biofilm into the water. Additional studies with this model should determine if sodium hypochlorite has a comparative effect and if other nontuberculous mycobacteria (NTM) respond to NH2Cl similarly. C1 [Armbruster, Catherine R.] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA. [Forster, Terri S.; Donlan, Rodney M.; O'Connell, Heather A.; Shams, Alicia M.; Williams, Margaret M.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. RP Williams, MM (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. EM MWilliams7@cdc.gov FU National Center for Environmental Health in the Centers for Disease Control and Prevention (CDC) FX The authors thank Jody Shoemaker of DeKalb County Watershed Management for providing water quality data. Sarah Gilbert and Elizabeth Perez are also thanked for technical assistance. Funding for this work was provided by the National Center for Environmental Health in the Centers for Disease Control and Prevention (CDC). The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the US CDC. NR 50 TC 5 Z9 5 U1 2 U2 10 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0892-7014 EI 1029-2454 J9 BIOFOULING JI Biofouling PY 2012 VL 28 IS 10 BP 1129 EP 1139 DI 10.1080/08927014.2012.735231 PG 11 WC Biotechnology & Applied Microbiology; Marine & Freshwater Biology SC Biotechnology & Applied Microbiology; Marine & Freshwater Biology GA V30UD UT WOS:000208840000003 PM 23082863 ER PT S AU Patrangenaru, V Crane, MA Liu, X Descombes, X Derado, G Liu, W Balan, V Patrangenaru, VP Thompson, HW AF Patrangenaru, V. Crane, M. A. Liu, X. Descombes, X. Derado, G. Liu, W. Balan, V. Patrangenaru, V. P. Thompson, H. W. BE Udriste, C Balan, V TI Methodology for 3D scene reconstruction from digital camera images SO BSG PROCEEDINGS 19 SE BSG Proceedings LA English DT Proceedings Paper CT International Conference of Differential Geometry and Dynamical Systems (DGDS-2011) CY OCT 06-09, 2011 CL Bucharest, ROMANIA SP Univ Politehn Bucharest, Romanian Fulbright Alumni Assoc DE projective shape reconstruction; statistical analysis; texture; affine transformations ID LARGE-SAMPLE; SHAPE; MANIFOLDS AB Digital images provide today an important source of data that deserves a careful statistical analysis. This paper concerns methods for retrieval of 3D information, including shape and texture, from cheap digital camera imaging outputs. It includes a three step reconstruction of a 3D scene with texture, from arbitrary partial views, in absence of occlusions. In Patrangenaru and Patrangenaru [23], Mardia et. al. [20] and Patrangenaru and Mardia [24] a planar scene was reconstructed using image fusion, around representatives of sample mean projective shapes or sample mean affine shapes of landmark configurations shared by a number of partial views of the scene. In this paper we first analyze the advantages and limitations of such a reconstruction of a close to planar remote scene from its partial aerial views, by specializing this algorithm to affine transformations. Furthermore, we combine a projective shape reconstruction of a finite 3D configuration from its uncalibrated camera views, as developed in Patrangenaru, Liu and Sughatadasa [22], with a VRML technique, to reconstruct projectively a 3D scene with texture from a pair of digital camera images, thus allowing a more detailed statistical analysis of the scene pictured. We give three such examples of 3D reconstructions. C1 [Patrangenaru, V.; Liu, X.; Liu, W.] Florida State Univ, Tallahassee, FL 32306 USA. [Crane, M. A.] EPA, Cincinnati, OH USA. [Descombes, X.] INRIA, Sophia Antipolis, France. [Derado, G.] Ctr Dis Control, Atlanta, GA 30333 USA. [Balan, V.] Univ Politehn, Bucharest, Romania. [Patrangenaru, V. P.] Georgia Tech Alumni Assoc, Atlanta, GA USA. [Thompson, H. W.] Louisiana State Univ, New Orleans, LA USA. RP Patrangenaru, V (reprint author), Florida State Univ, Tallahassee, FL 32306 USA. FU National Science Foundation [DMS-1106935, DMS-0805977, DMS-0713012]; INRIA-FSU Associated Team SHAPES; NSA [MSP-H98230-08-1-0058]; National Science Foundation; National Security Agency; INRIA; Centre National de la Recherche Scientifique - France FX Research supported by National Science Foundation Grants DMS-1106935, DMS-0805977, DMS-0713012, by INRIA-FSU Associated Team SHAPES and by the NSA Grant MSP-H98230-08-1-0058. The authors are grateful to the National Science Foundation, National Security Agency and INRIA and Centre National de la Recherche Scientifique - France for their support. Thanks to Sam Sughatadasa, for providing the images for Example 1. NR 27 TC 0 Z9 0 U1 0 U2 0 PU GEOMETRY BALKAN PRESS PI BUCHAREST PA UNIV POLITEHNICA BUCHAREST, FAC APPL SCI, DEPT MATH I, SPLAIUL INDEPENDENTEI 313, BUCHAREST, RO-060042, ROMANIA SN 1843-2654 J9 BSG PROC PY 2012 VL 19 BP 110 EP 124 PG 15 WC Mathematics SC Mathematics GA BG9KE UT WOS:000393360600013 ER PT J AU Grimes, DA Lopez, LM Gallo, MF Halpern, V Nanda, K Schulz, KF AF Grimes, David A. Lopez, Laureen M. Gallo, Maria F. Halpern, Vera Nanda, Kavita Schulz, Kenneth F. TI Steroid hormones for contraception in men SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS LA English DT Review DE Contraceptive Agents, Male; Contraception [methods]; Contraceptives, Oral, Hormonal; Contraceptives, Oral, Synthetic; Drug Implants; Levonorgestrel; Oligospermia [chemically induced]; Randomized Controlled Trials as Topic; Testosterone [analogs & derivatives]; Humans; Male ID INTRAMUSCULAR TESTOSTERONE UNDECANOATE; EFFECTIVELY SUPPRESSES SPERMATOGENESIS; DEPOT MEDROXYPROGESTERONE ACETATE; RANDOMIZED CONTROLLED-TRIALS; PITUITARY-TESTICULAR AXIS; NORMAL YOUNG MEN; CLINICAL-TRIAL; CHINESE MEN; NORETHISTERONE ENANTHATE; LEVONORGESTREL IMPLANTS AB Background Male hormonal contraception has been an elusive goal. Administration of sex steroids to men can shut off sperm production through effects on the pituitary and hypothalamus. However, this approach also decreases production of testosterone, so 'add-back' therapy is needed. Objectives To summarize all randomized controlled trials (RCTs) of male hormonal contraception. Search methods In January and February 2012, we searched the computerized databases CENTRAL, MEDLINE, POPLINE, and LILACS. We also searched for recent trials in ClinicalTrials.gov and ICTRP. Previous searches included EMBASE. We wrote to authors of identified trials to seek additional unpublished or published trials. Selection criteria We included all RCTs that compared a steroid hormone with another contraceptive. We excluded non-steroidal male contraceptives, such as gossypol. We included both placebo and active-regimen control groups. Data collection and analysis The primary outcome measure was the absence of spermatozoa on semen examination, often called azoospermia. Data were insufficient to examine pregnancy rates and side effects. Main results We found 33 trials that met our inclusion criteria. The proportion of men who reportedly achieved azoospermia or had no detectable sperm varied widely. A few important differences emerged. 1) Levonorgestrel implants (160 mu g daily) combined with injectable testosterone enanthate (TE) were more effective than levonorgestrel 125 mu g daily combined with testosterone patches. 2) Levonorgestrel 500 mu g daily improved the effectiveness of TE 100 mg injected weekly. 3) Levonorgestrel 250 mu g daily improved the effectiveness of testosterone undecanoate (TU) 1000 mg injection plus TU 500 mg injected at 6 and 12 weeks. 4) Desogestrel 150 mu g was less effective than desogestrel 300 mu g (with testosterone pellets). 5) TU 500 mg was less likely to produce azoospermia than TU 1000 mg (with levonorgestrel implants). 6) Norethisterone enanthate 200 mg with TU 1000 mg led to more azoospermia when given every 8 weeks versus 12 weeks. 7) Four implants of 7-alpha-methyl-19-nortestosterone (MENT) were more effective than two MENT implants. We did not conduct any meta-analysis due to intervention differences. Several trials showed promising efficacy in percentages with azoospermia. Three examined desogestrel and testosterone preparations or etonogestrel and testosterone, and two examined levonorgestrel and testosterone. Authors' conclusions No male hormonal contraceptive is ready for clinical use. Most trials were small exploratory studies. Their power to detect important differences was limited and their results imprecise. In addition, assessment of azoospermia can vary by sensitivity of the method used. Future trials need more attention to the methodological requirements for RCTs. More trials with adequate power would also be helpful. C1 [Grimes, David A.] Univ N Carolina, Sch Med, Chapel Hill, NC 27599 USA. [Lopez, Laureen M.; Schulz, Kenneth F.] FHI 360, Res Triangle Pk, NC USA. [Gallo, Maria F.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA. [Nanda, Kavita] FHI, Res Triangle Pk, NC USA. [Schulz, Kenneth F.] UNC Sch Med, Res Triangle Pk, NC USA. RP Grimes, DA (reprint author), Univ N Carolina, Sch Med, CB 7570,Chapel Hill, Chapel Hill, NC 27599 USA. EM david_grimes@med.unc.edu FU National Institute of Child Health and Human Development, USA; U. S. Agency for International Development, USA FX External sources; National Institute of Child Health and Human Development, USA.; U. S. Agency for International Development, USA. NR 82 TC 2 Z9 2 U1 0 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1469-493X EI 1361-6137 J9 COCHRANE DB SYST REV JI Cochrane Database Syst Rev. PY 2012 IS 3 AR CD004316 DI 10.1002/14651858.CD004316.pub4 PG 87 WC Medicine, General & Internal SC General & Internal Medicine GA 908QQ UT WOS:000301505600051 PM 22419294 ER PT J AU Mertens, CJ Kress, BT Wiltberger, M Tobiska, WK Grajewski, B Xu, XJ AF Mertens, Christopher J. Kress, Brian T. Wiltberger, Michael Tobiska, W. Kent Grajewski, Barbara Xu, Xiaojing BE Nenoi, M TI Atmospheric Ionizing Radiation from Galactic and Solar Cosmic Rays SO CURRENT TOPICS IN IONIZING RADIATION RESEARCH LA English DT Article; Book Chapter ID DOSE CONVERSION COEFFICIENTS; ENERGETIC PARTICLE EVENT; FEMALE FLIGHT ATTENDANTS; CANCER INCIDENCE; COMMERCIAL AVIATION; AIRCRAFT ALTITUDES; GEOMAGNETIC CUTOFF; SPACE EXPLORATION; PUBLISHED DATA; CREW-MEMBERS C1 [Mertens, Christopher J.] NASA, Langley Res Ctr, Hampton, VA 23665 USA. [Kress, Brian T.] Dartmouth Coll, Hanover, NH 03755 USA. [Wiltberger, Michael] Natl Ctr Atmospher Res, High Altitude Observ, Boulder, CO 80307 USA. [Tobiska, W. Kent] Space Environm Technol, Pacific Palisades, CA USA. [Grajewski, Barbara] NIOSH, Cincinnati, OH 45226 USA. [Xu, Xiaojing] Sci Syst & Applicat Inc, Lanham, MD USA. RP Mertens, CJ (reprint author), NASA, Langley Res Ctr, Hampton, VA 23665 USA. NR 128 TC 10 Z9 10 U1 1 U2 1 PU INTECH EUROPE PI RIJEKA PA JANEZA TRDINE9, RIJEKA, 51000, CROATIA BN 978-953-51-0196-3 PY 2012 BP 683 EP 738 D2 10.5772/2027 PG 56 WC Biochemistry & Molecular Biology; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Biochemistry & Molecular Biology; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA BG2EG UT WOS:000387290700032 ER PT J AU Bai, Y Kosoy, M AF Bai, Ying Kosoy, Michael BE RodriguezMorales, AJ TI Bartonella Infections in Rodents and Bats in Tropics SO CURRENT TOPICS IN TROPICAL MEDICINE LA English DT Article; Book Chapter ID CAT-SCRATCH DISEASE; COMPONENT COMMUNITY STRUCTURE; LAKE DISTRICT REGION; SMALL MAMMALS; SP-NOV; FLEAS SIPHONAPTERA; RESERVOIR HOSTS; UNITED-STATES; NEW-WORLD; PHYLOGENETIC ANALYSIS C1 [Bai, Ying; Kosoy, Michael] Ctr Dis Control & Prevent, Div Vector Borne Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30329 USA. RP Bai, Y (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30329 USA. NR 86 TC 2 Z9 2 U1 0 U2 0 PU INTECH EUROPE PI RIJEKA PA JANEZA TRDINE9, RIJEKA, 51000, CROATIA BN 978-953-51-0274-8 PY 2012 BP 51 EP 66 D2 10.5772/1335 PG 16 WC Tropical Medicine SC Tropical Medicine GA BE9SW UT WOS:000378147300005 ER PT J AU Crill, WD Hughes, HR Trainor, NB Davis, BS Whitney, MT Chang, GJJ AF Crill, Wayne D. Hughes, Holly R. Trainor, Nicole B. Davis, Brent S. Whitney, Matt T. Chang, Gwong-Jen J. TI Sculpting humoral immunity through dengue vaccination to enhance protective immunity SO FRONTIERS IN IMMUNOLOGY LA English DT Article DE dengue; dengue vaccines; DNA vaccines; immune refocusing; vaccine safety; antibody-dependent enhancement; original antigenic sin; dengue hemorrhagic fever AB Dengue viruses (DENV) are the most important mosquito transmitted viral pathogens infecting humans. DENV infection produces a spectrum of disease, most commonly causing a self-limiting flu-like illness known as dengue fever; yet with increased frequency, manifesting as life-threatening dengue hemorrhagic fever (DHF). Waning cross-protective immunity from any of the four dengue serotypes may enhance subsequent infection with another heterologous serotype to increase the probability of DHF. Decades of effort to develop dengue vaccines are reaching the finishing line with multiple candidates in clinical trials. Nevertheless, concerns remain that imbalanced immunity, due to the prolonged prime-boost schedules currently used in clinical trials, could leave some vaccinees temporarily unprotected or with increased susceptibility to enhanced disease. Here we develop a DENV serotype 1 (DENV-1) DNA vaccine with the immunodominant cross-reactive B cell epitopes associated with immune enhancement removed. We compare wild-type (WT) with this cross-reactivity reduced (CRR) vaccine and demonstrate that both vaccines are equally protective against lethal homologous DENV-1 challenge. Under conditions mimicking natural exposure prior to acquiring protective immunity, WT vaccinated mice enhanced a normally sub-lethal heterologous DENV-2 infection resulting in DHF-like disease and 95% mortality in AG 129 mice. However, CRR vaccinated mice exhibited redirected serotype-specific and protective immunity, and significantly reduced morbidity and mortality not differing from naive mice. Thus, we demonstrate in an in vivo DENV disease model, that non-protective vaccine-induced immunity can prime vaccinees for enhanced DHF-like disease and that CRR DNA immunization significantly reduces this potential vaccine safety concern. The sculpting of immune memory by the modified vaccine and resulting redirection of humoral immunity provide insight into DENV vaccine-induced immune responses. C1 [Crill, Wayne D.; Hughes, Holly R.; Trainor, Nicole B.; Davis, Brent S.; Whitney, Matt T.; Chang, Gwong-Jen J.] Ctr Dis Control & Prevent, Arboviral Dis Branch, Div Vector Borne Dis, Publ Hlth Serv,US Dept Hlth & Human Serv, Ft Collins, CO 80521 USA. RP Crill, WD (reprint author), Ctr Dis Control & Prevent, Arboviral Dis Branch, Div Vector Borne Dis, Publ Hlth Serv,US Dept Hlth & Human Serv, POB 2087,3156 Rampart Rd, Ft Collins, CO 80521 USA. EM wcrill@cdc.gov; gxc7@cdc.gov FU CDC DVBD FX We thank Danielle Mayer, Michelle Conetta, Shirstine Gordon, and Danielle Holligan for technical assistance and Dr. Sujan Shresta and her lab for the generous gift of DENV-2 S221 virus. Barbara Powers of the Colorado State University Veterinary Teaching Hospital provided histology and pathology interpretations along with Dr. Nord Zeidner (CDC, DVBD) who generously assisted with histology photos and additional interpretations. CDC DVBD is a federally funded national public health lab (USCDC) and all funding for this work was supported by such federal funding. Holly R. Hughes, Nicole B. Trainor, and Matt T. Whitney were supported by a federally funded contract to Columbus Technologies and Services, Inc. NR 87 TC 14 Z9 14 U1 0 U2 1 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-3224 J9 FRONT IMMUNOL JI Front. Immunol. PY 2012 VL 3 AR 334 DI 10.3389/fimmu.2012.00334 PG 19 WC Immunology SC Immunology GA V40TQ UT WOS:000209501300329 PM 23162552 ER PT S AU Lee, B Rota, PA AF Lee, Benhur Rota, Paul A. BE Lee, B Rota, PA TI Henipavirus Ecology, Molecular Virology, and Pathogenesis Preface SO HENIPAVIRUS: ECOLOGY, MOLECULAR VIROLOGY, AND PATHOGENESIS SE Current Topics in Microbiology and Immunology LA English DT Editorial Material; Book Chapter C1 [Lee, Benhur] Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA. [Rota, Paul A.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Lee, B (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Immunol & Mol Genet, BSRB 251a,615 Charles E Young Dr East, Los Angeles, CA 90095 USA. EM bleebhl@ucla.edu; prota@cdc.gov RI Lee, Benhur/A-8554-2016 OI Lee, Benhur/0000-0003-0760-1709 NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0070-217X BN 978-3-642-29819-6; 978-3-642-29818-9 J9 CURR TOP MICROBIOL JI Curr.Top.Microbiol.Immunol. PY 2012 VL 359 BP V EP VI D2 10.1007/978-3-642-29819-6 PG 2 WC Marine & Freshwater Biology; Virology SC Marine & Freshwater Biology; Virology GA BJT97 UT WOS:000330362500001 ER PT S AU Lo, MK Rota, PA AF Lo, Michael K. Rota, Paul A. BE Lee, B Rota, PA TI Molecular Virology of the Henipaviruses SO HENIPAVIRUS: ECOLOGY, MOLECULAR VIROLOGY, AND PATHOGENESIS SE Current Topics in Microbiology and Immunology LA English DT Review; Book Chapter ID VIRUS FUSION PROTEIN; INDEPENDENT RIBOSOMAL INITIATION; EMERGENT DEADLY PARAMYXOVIRUS; RESPIRATORY SYNCYTIAL VIRUS; AMINO-ACID SUBSTITUTIONS; NIPAH-VIRUS; HENDRA-VIRUS; SENDAI-VIRUS; V-PROTEIN; F-PROTEIN AB Nipah (NiV) and Hendra (HeV) viruses comprise the genus Henipavirus and are highly pathogenic paramyxoviruses, which cause fatal encephalitis and respiratory disease in humans. Since their respective initial outbreaks in 1998 and 1994, they have continued to cause sporadic outbreaks resulting in fatal disease. Due to their designation as Biosafety Level 4 pathogens, the level of containment required to work with live henipaviruses is available only to select laboratories around the world. This chapter provides an overview of the molecular virology of NiV and HeV including comparisons to other, well-characterized paramyxoviruses. This chapter also describes the sequence diversity present among the henipaviruses. C1 [Lo, Michael K.; Rota, Paul A.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Rota, PA (reprint author), Ctr Dis Control & Prevent, MS-C-22,1600 Clifton Rd, Atlanta, GA 30333 USA. EM prota@cdc.gov OI Lo, Michael/0000-0002-0409-7896 NR 113 TC 4 Z9 4 U1 0 U2 2 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0070-217X BN 978-3-642-29819-6; 978-3-642-29818-9 J9 CURR TOP MICROBIOL JI Curr.Top.Microbiol.Immunol. PY 2012 VL 359 BP 41 EP 58 DI 10.1007/82_2012_211 D2 10.1007/978-3-642-29819-6 PG 18 WC Marine & Freshwater Biology; Virology SC Marine & Freshwater Biology; Virology GA BJT97 UT WOS:000330362500005 ER PT J AU Lehman, EJ Huy, JM Viet, SM Gomaa, A AF Lehman, Everett J. Huy, Janice M. Viet, Susan M. Gomaa, Ahmed TI Compliance With Bloodborne Pathogen Standards at Eight Correctional Facilities SO JOURNAL OF CORRECTIONAL HEALTH CARE LA English DT Article DE bloodborne pathogens; correctional health care; needlestick; hepatitis B; NSPA AB This study had three objectives: (a) to examine compliance with the Occupational Safety and Health Administration (OSHA) Bloodborne Pathogens (BBPs) Standard at eight correctional facilities, (b) to identify potential barriers to compliance, and (c) to discuss steps to address these barriers. Eight facilities of different sizes and locations were visited to examine employer adherence to 15 selected BBP risk reduction activities. Facility compliance was less than 50% for four activities: updating exposure control plans, implementing use of appropriate safer medical devices, soliciting employee input on selection of safer devices, and training medical staff when such devices are implemented. Inconsistent compliance may be due to difficulties in applying the standards in the correctional health care work setting. Any BBP training and health communication activities targeted to correctional health care workers should be tailored to the correctional facility setting. C1 [Lehman, Everett J.] NIOSH, Ind Studies Branch, Div Surveillance Hazard Evaluat & Field Studies, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Huy, Janice M.] NIOSH, Off Director, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Viet, Susan M.] Westat Corp, Rockville, MD USA. [Gomaa, Ahmed] NIOSH, Surveillance Branch, Div Surveillance Hazard Evaluat & Field Studies, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. RP Lehman, EJ (reprint author), NIOSH, Ind Studies Branch, Div Surveillance Hazard Evaluat & Field Studies, Ctr Dis Control & Prevent, 4676 Columbia Pkwy,R-13, Cincinnati, OH 45226 USA. EM ELehman@cdc.gov NR 26 TC 1 Z9 1 U1 0 U2 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1078-3458 EI 1940-5200 J9 J CORRECT HEALTH CAR JI J. Correct. Health Care PD JAN PY 2012 VL 18 IS 1 BP 29 EP 44 DI 10.1177/1078345811421466 PG 16 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA V32ZI UT WOS:000208988700004 PM 22209817 ER PT J AU Leeb, RT Bitsko, RH Merrick, MT Armour, BS AF Leeb, Rebecca T. Bitsko, Rebecca H. Merrick, Melissa T. Armour, Brian S. TI Does Childhood Disability Increase Risk for Child Abuse and Neglect? SO JOURNAL OF MENTAL HEALTH RESEARCH IN INTELLECTUAL DISABILITIES LA English DT Article DE child maltreatment; disability; review AB In this article we review the empirical evidence for the presumptions that children with disabilities are at increased risk for child maltreatment, and parents with disabilities are more likely to perpetrate child abuse and neglect. Challenges to the epidemiological examination of the prevalence of child maltreatment and disabilities are discussed. We conclude that the evidence for the relationship between child maltreatment victimization of children with disabilities and perpetration by caregivers with disabilities remains equivocal due to variability in research samples, key definitions, and study methodology. Future research examining the link between disability and child maltreatment would benefit from more rigorous methodology and inclusion of a theoretical framework, such as the ecological model of child maltreatment. One potential pathway from disability to child maltreatment is presented. Knowing and understanding the link between disability and child abuse and neglect is an important step toward planning targeted and appropriate prevention and intervention activities. C1 [Leeb, Rebecca T.; Bitsko, Rebecca H.; Armour, Brian S.] Ctr Dis Control & Prevent, Div Human Dev & Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Merrick, Melissa T.] Ctr Dis Control & Prevent, Div Violence Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA. RP Leeb, RT (reprint author), 1600 Clifton Rd,MS E-88, Atlanta, GA 30333 USA. EM RLeeb@CDC.gov NR 66 TC 4 Z9 4 U1 6 U2 11 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1931-5864 EI 1931-5872 J9 J MENT HEALTH RES IN JI J. Ment. Health Res. Intellect. Disabil. PY 2012 VL 5 IS 1 SI SI BP 4 EP 31 DI 10.1080/19315864.2011.608154 PG 28 WC Education, Special; Psychiatry; Rehabilitation SC Education & Educational Research; Psychiatry; Rehabilitation GA V33IV UT WOS:000209013400002 ER PT J AU Gaskin, EH Lutzker, JR Crimmins, DB Robinson, L AF Gaskin, Emily H. Lutzker, John R. Crimmins, Daniel B. Robinson, Lara TI Using a Digital Frame and Pictorial Information to Enhance the SafeCare (R) Parent-Infant Interactions Module With a Mother with Intellectual Disabilities: Results of a Pilot Study SO JOURNAL OF MENTAL HEALTH RESEARCH IN INTELLECTUAL DISABILITIES LA English DT Article DE child maltreatment; child neglect; parents with intellectual disability; parent-infant interactions; technology; SafeCare (R); self-modeling AB Parents with intellectual disabilities (ID) are disproportionately represented in the child welfare system. Parents with ID can be better served by developing curricula that support various modes of learning. Technology offers a potentially effective tool because it is visual, interactive, and self-instructional. SafeCare (R) is an evidence-based parenting program with flexibility to adapt its curricula while maintaining fidelity. This research presents the results of a pilot study that examined the effectiveness of an adaptation to the SafeCare (R) parent-infant interactions (PII) module for a mother with ID by using a digital picture frame with pictures of the mother and her infant engaged in skills that met the performance criteria for PII. A multiple-probe design across behaviors was used with the mother and her infant, showing a dramatic increase in PII skills that was maintained across 3 monthly follow-ups.Although further research is necessary, the preliminary data suggest the digital picture frame enhancement to the SafeCare (R) PII module may be a promising instructional tool for parents with ID. C1 [Gaskin, Emily H.; Lutzker, John R.] Georgia State Univ, Inst Publ Hlth, Atlanta, GA 30302 USA. [Lutzker, John R.] Georgia State Univ, Ctr Hlth Dev, Atlanta, GA 30302 USA. [Crimmins, Daniel B.] State Univ, Ctr Leadership Disabil, Atlanta, GA USA. [Crimmins, Daniel B.] State Univ, Ctr Hlth Dev, Atlanta, GA USA. [Robinson, Lara] US Ctr Dis Control & Prevent, Atlanta, GA USA. RP Lutzker, JR (reprint author), Georgia State Univ, Ctr Hlth Dev, Box 3995, Atlanta, GA 30302 USA. EM jlutzker@gsu.edu NR 30 TC 2 Z9 3 U1 0 U2 5 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1931-5864 EI 1931-5872 J9 J MENT HEALTH RES IN JI J. Ment. Health Res. Intellect. Disabil. PY 2012 VL 5 IS 2 SI SI BP 187 EP 202 DI 10.1080/19315864.2012.674871 PG 16 WC Education, Special; Psychiatry; Rehabilitation SC Education & Educational Research; Psychiatry; Rehabilitation GA V33IY UT WOS:000209013700006 PM 28261369 ER PT J AU Mayo-Ortega, L Oyama-Ganiko, R Leblanc, J Schroeder, SR Brady, N Butler, MG Reese, RM Richman, DM Peacock, G Foster, J Marquis, J AF Mayo-Ortega, Liliana Oyama-Ganiko, Rosa Leblanc, Judith Schroeder, Stephen R. Brady, Nancy Butler, Merlin G. Reese, R. Matthew Richman, David M. Peacock, Georgina Foster, Jessica Marquis, Janet TI Mass Screening for Severe Problem Behavior Among Infants and Toddlers in Peru SO JOURNAL OF MENTAL HEALTH RESEARCH IN INTELLECTUAL DISABILITIES LA English DT Article DE severe aggression; self-injurious behavior; stereotyped behavior; behavior problems; intellectual disabilities; infants and toddlers; early prevention AB Severe behavior problems among people with intellectual and developmental disabilities (IDD) are a major barrier to integration in the community. Recent research suggests that these behaviors often begin very early in life and might be prevented by early identification and intervention (Rojahn, Schroeder, & Hoch, 2008). The current article presents a method of mass screening for early signs of severe behavior problems among infants and toddlers in Peru. A Parental Concerns Questionnaire (PCQ), which asks 15 questions, each related to a risk factor for severe behavior problems, based on past research on IDD, was used by veteran parents to interview 341 new parents who had been solicited by TV, radio, and public service announcements across the country. Of these, 262 were recruited and enrolled in a longitudinal study in which they will be followed for 12 months to see if at-risk children actually will develop severe behavior problems. An extensive initial interdisciplinary evaluation was given to each child. Consumer satisfaction questionnaires were given to the parents as to their attitude toward the screening method. Data from the Interdisciplinary Evaluations of the sample suggest a very high hit rate (96%) by the screening instrument (PCQ). Consumer satisfaction was 98%, suggesting that the method was tolerated well by parents. The PCQ is a brief and efficient method to screen infants and toddlers at risk for severe behavior problems. The data also suggest that parents suspect these problems at a very early age. Early intervention thus seems a feasible strategy to intervene before these problems become deeply ingrained as children develop. C1 [Mayo-Ortega, Liliana; Oyama-Ganiko, Rosa; Leblanc, Judith] Ctr Ann Sullivan Peru, Lima, Peru. [Mayo-Ortega, Liliana; Leblanc, Judith; Schroeder, Stephen R.] Univ Kansas, Dept Appl Behav Sci, Lawrence, KS 66045 USA. [Schroeder, Stephen R.; Brady, Nancy; Marquis, Janet] Univ Kansas, Life Span Inst, Lawrence, KS 66045 USA. [Brady, Nancy] Univ Kansas, Dept Speech Commun & Hearing Res, Lawrence, KS 66045 USA. [Butler, Merlin G.] Univ Kansas, Med Ctr, Dept Pediat & Psychiat, Lawrence, KS 66045 USA. [Reese, R. Matthew] Univ Kansas, Med Ctr, Ctr Child Hlth Dev, Lawrence, KS 66045 USA. [Reese, R. Matthew] Univ Kansas, Med Ctr, Dept Pediat, Lawrence, KS 66045 USA. [Richman, David M.] Texas Tech Univ, Burkhart Ctr Autism & Educ Res, Lubbock, TX 79409 USA. [Peacock, Georgina] Ctr Dis Control & Prevent, Atlanta, GA USA. [Foster, Jessica] Ohio Dept Hlth, Columbus, OH 43266 USA. RP Schroeder, SR (reprint author), Univ Kansas, Life Span Inst, 1000 Sunnyside Ave, Lawrence, KS 66045 USA. EM srs@ku.edu FU NICHD NIH HHS [R21 HD060500, P30 HD002528] NR 29 TC 7 Z9 7 U1 0 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1931-5864 EI 1931-5872 J9 J MENT HEALTH RES IN JI J. Ment. Health Res. Intellect. Disabil. PY 2012 VL 5 IS 3-4 SI SI BP 246 EP 259 DI 10.1080/19315864.2011.590626 PG 14 WC Education, Special; Psychiatry; Rehabilitation SC Education & Educational Research; Psychiatry; Rehabilitation GA V33JB UT WOS:000209014000004 PM 22962573 ER PT J AU Pierce, CL Rees, JC Fernandez, FM Barr, JR AF Pierce, Carrie L. Rees, Jon C. Fernandez, Facundo M. Barr, John R. TI Viable Staphylococcus aureus Quantitation using N-15 Metabolically Labeled Bacteriophage Amplification Coupled with a Multiple Reaction Monitoring Proteomic Workflow SO MOLECULAR & CELLULAR PROTEOMICS LA English DT Article ID SPECTROMETRY-BASED PROTEOMICS; FLIGHT-MASS-SPECTROMETRY; ESCHERICHIA-COLI O157-H7; STATISTICAL-MODEL; CELL-CULTURE; AMINO-ACIDS; PROTEINS; QUANTIFICATION; IDENTIFICATION; DIGESTION AB A multiple reaction monitoring liquid chromatography method with tandem mass spectrometric detection for quantitation of Staphylococcus aureus via phage amplification detection is described. This phage amplification detection method enables rapid and accurate quantitation of viable S. aureus by detecting an amplified capsid protein from a specific phage. A known amount of metabolically labeled N-15 reference bacteriophage, utilized as the input phage and as the internal standard for quantitation, was spiked into S. aureus samples. Following a 2-h incubation, the sample was subjected to a 3-min rapid trypsin digest and analyzed by high-throughput liquid chromatography tandem mass spectrometric detection targeting peptides unique to both the N-15 (input phage) and N-14 (progeny phage) capsid proteins. Quantitation was achieved by comparing peak areas of target peptides from the metabolically labeled N-15 bacteriophage peptide internal standard with that of the wild-type N-14 peptides that were produced by phage amplification and subsequent digestion when the host bacteria was present. This approach is based on the fact that a labeled species differs from the unlabeled one in terms of its mass but exhibits almost identical chemical properties such as ion yields and retention times. A 6-point calibration curve for S. aureus concentration was constructed with standards ranging from 5.0 x 10(4) colony forming units (CFU) ml(-1) to 2.0 x 10(6) CFU ml(-1), with the N-15 reference phage spiked at a concentration of 1.0 x 10(9) plaque forming units (PFU) ml(-1). Amplification with N-15 bacteriophage coupled with LC-MS/MS detection offers speed (3 h total analysis time), sensitivity (LOD: < 5.0 x 10(4) CFU ml(-1)), accuracy, and precision for quantitation of S. aureus. Molecular & Cellular Proteomics 11: 10.1074/mcp.M111.012849, 1-11, 2012. C1 [Pierce, Carrie L.; Rees, Jon C.; Barr, John R.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Pierce, Carrie L.; Fernandez, Facundo M.] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA. RP Barr, JR (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, 4770 Buford Highway,MS F-50, Atlanta, GA 30341 USA. EM JBarr@cdc.gov RI Fernandez, Facundo/B-7015-2008 FU 3M; GT/CDC FX FMF gratefully acknowledges funding by 3M through a Nontenured Faculty Award and the GT/CDC seed funding program. NR 59 TC 4 Z9 4 U1 0 U2 2 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 1535-9476 EI 1535-9484 J9 MOL CELL PROTEOMICS JI Mol. Cell. Proteomics PD JAN PY 2012 VL 11 IS 1 AR M111.012849 DI 10.1074/mcp.M111.012849 PG 11 WC Biochemical Research Methods SC Biochemistry & Molecular Biology GA 876KK UT WOS:000299106200015 PM 21972246 ER PT B AU Ku, BK Deye, G Turkevich, LA AF Ku, Bon Ki Deye, Gregory Turkevich, Leonid A. BE Laudon, M Romanowicz, B TI Characterization of a Vortex Shaking Method for Producing Airborne Glass Fibers for Toxicology Studies SO NANOTECHNOLOGY 2012, VOL 3: BIO SENSORS, INSTRUMENTS, MEDICAL, ENVIRONMENT AND ENERGY LA English DT Proceedings Paper CT NSTI Nanotechnology Conference and Expo (Nanotech 2012) CY JUN 18-21, 2012 CL Santa Clara, CA SP ACCT Canada, Anaheim Ctr New Energy Technol, Angel Capital Assoc, Antenna Syst Magazine, Appl Mat, Arsenal Venture Partners, Austin Energy, AUTM, BASF, Battery Power Magazine, Carbon Credit Capital, CHInano2011, Clean Technol & Sustainable Ind, Org CTSI, Circuits Multi Projets, Constellat Energy, Eco Business com, EcoSeed, European Patent Off, Fraunhofer TechBridge, GigaOM, Green Blog Network, Greenberg Traurig, Hitachi High Technol Am Inc, Inst Civil Engineers, Insight InterAsia, IOP Publish, Jackson Walker LLP, Japan Technol Grp, Kauffman Fdn, Lam Res Corp, Licens Execut Soc, Lux Res, Mead Westvaco, MEMS Ind Grp, Nano Sci & Technol Inst, nano tech Japan, Natl Grid, Natl Venture Capital Assoc, Nanotechnol Ind Assoc, NE Utilities, PPG Ind, SciTech Patent Art, Shell GameChanger, SK Innovat, So California Edison, Taylor & Francis Grp LLC - CRC Press, TechConnect, Texas Nanotechnol Initiat, Env Business Cluster, Natl Assoc Seed & Venture, Funds NASVF, Zyvex Technol DE glass fiber; vortex shaking; aerodynamic diameter; length ID NANOTUBES AB Generation of well-characterized fibers is important in toxicology studies. Fiber toxicity appears to be mostly a function of fiber concentration, dimensions (diameter and length) and durability in the lungs. In this study we characterized a vortex-tube shaking method to understand its particle generation characteristics. Aerodynamic size distributions were measured for different initial batch amounts of glass fibers in the vortex tube. Also, the effect of pre-shaking and concentration decay with time were investigated, and the potential for continuously running the vortex shaking generator was tested at two different flow rates (1.5 lpm and 0.1 lpm). The results showed that the higher the initial batch material is, the higher the total number concentration is, and the longer the initial plateau concentration is. While the duration and initial plateau concentration depend on the initial batch, the concentration starts to decay, which is very similar in all batches. Initial concentrations with pre-shaking are higher than those for the no pre-shaking case, and larger particles are generated for relatively long period. C1 [Ku, Bon Ki; Deye, Gregory; Turkevich, Leonid A.] NIOSH, CDC, Cincinnati, OH 45226 USA. RP Ku, BK (reprint author), NIOSH, CDC, Cincinnati, OH 45226 USA. EM bku@cdc.gov NR 7 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-6276-9 PY 2012 BP 358 EP 360 PG 3 WC Energy & Fuels; Engineering, Biomedical; Nanoscience & Nanotechnology; Toxicology SC Energy & Fuels; Engineering; Science & Technology - Other Topics; Toxicology GA BG7DZ UT WOS:000391249300092 ER PT B AU Roy, K Chaudhuri, A AF Roy, Kakoli Chaudhuri, Anoshua BE Kuhlmann, E Annandale, E TI Gender Differences in Healthcare Utilization in Later Life SO PALGRAVE HANDBOOK OF GENDER AND HEALTHCARE, 2ND EDITION LA English DT Article; Book Chapter ID OLDER-ADULT POPULATION; SOCIOECONOMIC-STATUS; SEEKING BEHAVIOR; SEX-DIFFERENCES; INFORMAL CARE; SERVICES; INEQUALITIES; DETERMINANTS; MORBIDITY; SPAIN C1 [Roy, Kakoli] US Dept HHS, Ctr Dis Control Prevent CDC, Washington, DC 20201 USA. RP Roy, K (reprint author), US Dept HHS, Ctr Dis Control Prevent CDC, Washington, DC 20201 USA. NR 40 TC 0 Z9 0 U1 2 U2 2 PU PALGRAVE PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE RG21 6XS, ENGLAND BN 978-1-137-29540-8; 978-1-137-01514-3 PY 2012 BP 256 EP 272 D2 10.1057/9781137295408 PG 17 WC Health Policy & Services; Women's Studies SC Health Care Sciences & Services; Women's Studies GA BG1QW UT WOS:000387024400017 ER PT B AU Monroe, J AF Monroe, Judy BE Dietz, JE Black, DR TI PANDEMIC PLANNING Foreword SO PANDEMIC PLANNING LA English DT Editorial Material; Book Chapter C1 [Monroe, Judy] OSTLTS, Atlanta, GA 30341 USA. [Monroe, Judy] Ctr Dis Control & Prevent CDC, Atlanta, GA USA. [Monroe, Judy] Natl Hlth Serv Corps, Nashville, TN USA. [Monroe, Judy] St Vincent Hosp, Family Med Residency Program, Indianapolis, IN USA. [Monroe, Judy] ASTHO, Arlington, VA USA. [Monroe, Judy] Purdue Univ, Indiana Publ Hlth Syst Qual Improvement Project P, W Lafayette, IN 47907 USA. RP Monroe, J (reprint author), OSTLTS, Atlanta, GA 30341 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-5767-0; 978-1-4398-5765-6 PY 2012 BP IX EP X D2 10.1201/b11779 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA BC8IS UT WOS:000355700100001 ER PT B AU Ainsworth, BE Macera, CA AF Ainsworth, Barbara E. Macera, Caroline A. BE Ainsworth, BE Macera, CA TI Physical Activity and Public Health Practice Preface SO PHYSICAL ACTIVITY AND PUBLIC HEALTH PRACTICE LA English DT Editorial Material; Book Chapter C1 [Ainsworth, Barbara E.] Arizona State Univ, Sch Nutr & Hlth Promot, Exercise & Wellness Program, Tempe, AZ 85287 USA. [Ainsworth, Barbara E.; Macera, Caroline A.] Amer Coll Sports Med, Indianapolis, IN USA. [Ainsworth, Barbara E.] Amer Alliance Hlth Phys Educ Recreat & Dance, Reston, VA USA. [Ainsworth, Barbara E.] Natl Acad Kinesiol, New York, NY USA. [Macera, Caroline A.] San Diego State Univ, Epidemiol, San Diego, CA 92182 USA. [Macera, Caroline A.] San Diego State Univ, Grad Sch Publ Hlth, San Diego, CA 92182 USA. [Macera, Caroline A.] Univ S Carolina, Columbia, SC 29208 USA. [Macera, Caroline A.] Ctr Dis Control & Prevent, Phys Act & Hlth Branch, Surveillance & Epidemiol, Atlanta, GA USA. RP Ainsworth, BE (reprint author), Arizona State Univ, Sch Nutr & Hlth Promot, Exercise & Wellness Program, Tempe, AZ 85287 USA. NR 8 TC 3 Z9 3 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-4952-1; 978-1-4398-4951-4 PY 2012 BP VII EP X D2 10.1201/b11718 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA BC8KG UT WOS:000355754400001 ER PT B AU Fulton, JE Carlson, SA AF Fulton, Janet E. Carlson, Susan A. BE Ainsworth, BE Macera, CA TI Surveillance of Physical Activity SO PHYSICAL ACTIVITY AND PUBLIC HEALTH PRACTICE LA English DT Article; Book Chapter ID UNITED-STATES; NEIGHBORHOOD ENVIRONMENTS; PREVALENCE; VALIDITY; SCALE; BRFSS C1 [Fulton, Janet E.; Carlson, Susan A.] Ctr Dis Control & Prevent, Phys Act & Hlth Branch, Div Nutr Phys Act & Obes, Atlanta, GA 30333 USA. RP Fulton, JE (reprint author), Ctr Dis Control & Prevent, Phys Act & Hlth Branch, Div Nutr Phys Act & Obes, Atlanta, GA 30333 USA. NR 41 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-4952-1; 978-1-4398-4951-4 PY 2012 BP 211 EP 235 D2 10.1201/b11718 PG 25 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA BC8KG UT WOS:000355754400014 ER PT B AU Dorn, J Hoebbel, C AF Dorn, Joan Hoebbel, Cassandra BE Ainsworth, BE Macera, CA TI Physical Activity Promotion in Worksites SO PHYSICAL ACTIVITY AND PUBLIC HEALTH PRACTICE LA English DT Article; Book Chapter ID RANDOMIZED CONTROLLED-TRIAL; CORONARY-HEART-DISEASE; SITE HEALTH-PROMOTION; ACTIVITY INTERVENTION; STAIR USE; ENVIRONMENTAL-CHANGES; ENERGY-EXPENDITURE; PUBLIC-HEALTH; COLON CANCER; WORK C1 [Dorn, Joan; Hoebbel, Cassandra] SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Exercise & Nutr Sci, Buffalo, NY 14260 USA. [Dorn, Joan; Hoebbel, Cassandra] SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Social & Prevent Med, Buffalo, NY 14260 USA. [Dorn, Joan] Ctr Dis Control & Prevent, Phys Act & Hlth Branch, Div Nutr Phys Act & Obes, Atlanta, GA USA. RP Dorn, J (reprint author), SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Exercise & Nutr Sci, Buffalo, NY 14260 USA. NR 63 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-4952-1; 978-1-4398-4951-4 PY 2012 BP 277 EP 302 D2 10.1201/b11718 PG 26 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA BC8KG UT WOS:000355754400017 ER PT B AU Kopfman, JE Ruth-McSwain, A AF Kopfman, Jenifer E. Ruth-McSwain, Amanda BE Lee, M Neeley, G Stewart, K TI Public Information Campaigns SO PRACTICE OF GOVERNMENT PUBLIC RELATIONS SE American Society for Public Administration Series on Public Administration and Public Policy LA English DT Article; Book Chapter C1 [Kopfman, Jenifer E.; Ruth-McSwain, Amanda] Coll Charleston, Dept Commun, Charleston, SC 29401 USA. [Kopfman, Jenifer E.] Ctr Dis Control & Prevent, Washington, DC USA. [Ruth-McSwain, Amanda] Amer Mkt Assoc, Board Charleston Chapter, New York, NY USA. [Ruth-McSwain, Amanda] Publ Relat Soc Amer, Lowcountry Chapter, New York, NY USA. RP Kopfman, JE (reprint author), Coll Charleston, Dept Commun, Charleston, SC 29401 USA. NR 11 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-3466-4; 978-1-4398-3465-7 J9 AM SOC PUBLIC ADMIN PY 2012 BP 75 EP 99 PG 25 WC Communication; Public Administration SC Communication; Public Administration GA BC9EJ UT WOS:000356376200006 ER PT J AU Klevens, J Sadowski, L Kee, R Trick, W Garcia, D AF Klevens, Joanne Sadowski, Laura Kee, Romina Trick, William Garcia, Diana TI Comparison of Screening and Referral Strategies for Exposure to Partner Violence SO WOMENS HEALTH ISSUES LA English DT Article AB Background: Although under debate, routine screening for intimate partner violence (IPV) is recommended in health care settings. This study explored the utility of different screening and referral strategies for women exposed to IPV in primary health care. Methods: Using a randomized controlled trial design we compared two screening strategies (health care providers [HCP] versus audio computer-assisted self-interviews [A-CASI]) and three referral strategies (HCP alone, A-CASI referral with HCP endorsement, and A-CASI alone). English-speaking women who were 18 years and older and were attending women's health clinics at a public hospital were eligible to participate. Participants were randomly assigned to one of three study groups (HCP screen and referral, A-CASI screen and referral with HCP referral endorsement, and A-CASI screen and referral). Women were reinterviewed by telephone 1 week later. The primary outcome was rate of IPV disclosure; secondary outcomes were screening mode preference, reactions to IPV screening, and use of referral resources. Results: Of the 129 eligible women, 126 women were enrolled (98%); 102 women (81% of those enrolled) completed the follow-up telephone interview. Disclosure rates were higher for women screened with A-CASI compared with HCP-screened women (21% vs. 9%; p = .07). Screening mode preference, impact of screening (positive and negative reactions), and rates of use of referral resources were similar between study groups. Conclusion: A-CASI tended to yield higher rates of IPV disclosure and similar rates of use of referral resources. A-CASI technology may be a practical way to screen for IPV. Published by Elsevier Inc. C1 [Klevens, Joanne] Ctr Dis Control & Prevent, Div Violence Prevent, Atlanta, GA 30341 USA. [Sadowski, Laura; Kee, Romina; Trick, William; Garcia, Diana] John H Stroger Hosp Cook Cty, Collaborat Res Unit, Chicago, IL USA. RP Klevens, J (reprint author), Ctr Dis Control & Prevent, Div Violence Prevent, 4770 Buford Hwy,Mailstop F-63, Atlanta, GA 30341 USA. EM jklevens@cdc.gov NR 52 TC 16 Z9 16 U1 3 U2 10 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1049-3867 EI 1878-4321 J9 WOMEN HEALTH ISS JI Womens Health Iss. PD JAN-FEB PY 2012 VL 22 IS 1 BP E45 EP E52 DI 10.1016/j.whi.2011.06.008 PG 8 WC Public, Environmental & Occupational Health; Women's Studies SC Public, Environmental & Occupational Health; Women's Studies GA V33SP UT WOS:000209038800006 PM 21798763 ER PT J AU McLellan-Lemal, E O'Daniels, CM Marks, G Villar-Loubet, O Doherty, IA Simpson, C Weiss, S Hanna, B Adimora, AA White, BL Wheeling, JT Borkowf, CB AF McLellan-Lemal, Eleanor O'Daniels, Christine M. Marks, Gary Villar-Loubet, Olga Doherty, Irene A. Simpson, Cathy Weiss, Stephen Hanna, Barbara Adimora, Adaora A. White, Becky L. Wheeling, John T. Borkowf, Craig B. TI Sexual Risk Behaviors among African-American and Hispanic Women in Five Counties in the Southeastern United States: 2008-2009 SO WOMENS HEALTH ISSUES LA English DT Article AB Purpose: We examined sexual risk behaviors and unrecognized HIV infection among heterosexually active African-American and Hispanic women. Methods: Women not previously diagnosed with HIV infection were recruited in rural counties in North Carolina (African American) and Alabama (African American), and an urban county in southern Florida (Hispanic) using multiple methods. They completed a computer-administered questionnaire and were tested for HIV infection. Results: Between October 2008 and September 2009, 1,527 women (1,013 African American and 514 Hispanic) enrolled in the study. Median age was 35 years (range, 18-59), 33% were married or living as married, 50% had an annual household income of $12,000 or less, and 56% were employed full or part time. Two women (0.13%) tested positive for HIV. In the past 12 months, 19% had been diagnosed with a sexually transmitted infection (other than HIV), 87% engaged in unprotected vaginal intercourse (UVI), and 26% engaged in unprotected anal intercourse (UAI). In multivariate analysis, UAI was significantly (p <.05) more likely among those who reported ever being pregnant, binge drinking in the past 30 days, ever exchanging sex for things needed or wanted, engaging in UVI, or being of Hispanic ethnicity. UAI was also more likely to occur with partners with whom women had a current or past relationship as opposed to casual partners. Conclusion: A high percentage of our sample of heterosexually active women of color had recently engaged in sexual risk behaviors, particularly UAI. More research is needed to elucidate the interpersonal dynamics that may promote this high-risk behavior. Educational messages that explicitly address the risks of heterosexual anal intercourse need to be developed for heterosexually active women and their male partners. Published by Elsevier Inc. C1 [McLellan-Lemal, Eleanor; O'Daniels, Christine M.; Marks, Gary; Wheeling, John T.; Borkowf, Craig B.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. [O'Daniels, Christine M.] Carter Consulting Inc, Atlanta, GA USA. [Villar-Loubet, Olga; Weiss, Stephen] Univ Miami, Miller Sch Med, Dept Psychiat & Behav Sci, Miami, FL 33136 USA. [Doherty, Irene A.] Univ N Carolina, Sch Med, Dept Med, Div Infect Dis, Chapel Hill, NC USA. [Adimora, Adaora A.] Univ N Carolina, Sch Med, Div Infect Dis, Chapel Hill, NC USA. [White, Becky L.] Univ N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC USA. [Simpson, Cathy] Univ Alabama Birmingham, Sch Publ Hlth, Dept Hlth Behav, Birmingham, AL 35294 USA. [Hanna, Barbara] Hlth Serv Ctr Inc, Anniston, AL USA. [Wheeling, John T.] Northrop Grumman, Atlanta, GA USA. RP McLellan-Lemal, E (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, 1600 Clifton Rd MS-E45, Atlanta, GA 30333 USA. EM egm4@cdc.gov OI McLellan-Lemal, Eleanor/0000-0002-1884-9315 FU NCHHSTP CDC HHS [PS05-197]; NIAID NIH HHS [P30 AI050410]; NIMH NIH HHS [K23 MH094250] NR 47 TC 11 Z9 11 U1 2 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1049-3867 EI 1878-4321 J9 WOMEN HEALTH ISS JI Womens Health Iss. PD JAN-FEB PY 2012 VL 22 IS 1 BP E9 EP E18 DI 10.1016/j.whi.2011.06.002 PG 10 WC Public, Environmental & Occupational Health; Women's Studies SC Public, Environmental & Occupational Health; Women's Studies GA V33SP UT WOS:000209038800002 PM 21784659 ER PT J AU Pinkerton, LE Waters, MA Hein, MJ Zivkovich, Z Schubauer-Berigan, MK Grajewski, B AF Pinkerton, Lynne E. Waters, Martha A. Hein, Misty J. Zivkovich, Zachary Schubauer-Berigan, Mary K. Grajewski, Barbara TI Cause-specific mortality among a cohort of U.S. flight attendants SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE LA English DT Article DE flight attendants; cancer; mortality; cohort; cosmic radiation; circadian rhythm disruption ID AIRLINE CABIN ATTENDANTS; BREAST-CANCER RISK; CIRCADIAN-RHYTHM DISRUPTION; COSMIC-RADIATION; COCKPIT CREW; PUBLISHED DATA; PILOTS; EXPOSURE; METAANALYSIS; HEALTH AB Background We evaluated mortality among 11,311 former U.S. flight attendants. The primary a priori outcomes of interest were breast cancer and melanoma. C1 [Pinkerton, Lynne E.; Waters, Martha A.; Hein, Misty J.; Zivkovich, Zachary; Schubauer-Berigan, Mary K.; Grajewski, Barbara] NIOSH, Industrywide Studies Branch, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH 45226 USA. RP Pinkerton, LE (reprint author), NIOSH, Industrywide Studies Branch, Div Surveillance Hazard Evaluat & Field Studies, 4676 Columbia Pkwy,R-15, Cincinnati, OH 45226 USA. EM lpinkerton@cdc.gov RI Schubauer-Berigan, Mary/B-3149-2009 OI Schubauer-Berigan, Mary/0000-0002-5175-924X FU Office of Women's Health of the U.S. Department of Health and Human Services FX This study was funded, in part, by the Office of Women's Health of the U.S. Department of Health and Human Services. We would like to thank the many people who obtained records, abstracted and edited data to construct the cohort, and abstracted and edited data from flight schedules to develop exposure estimates for this study. We would also like to thank Dr. Wallace Friedberg and Mr. Kyle Copeland of the FAA for providing the CARI program. We gratefully acknowledge the support of the U.S. states and the National Death Index in providing death certificate information for this study. NR 46 TC 14 Z9 15 U1 1 U2 11 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0271-3586 J9 AM J IND MED JI Am. J. Ind. Med. PD JAN PY 2012 VL 55 IS 1 BP 25 EP 36 DI 10.1002/ajim.21011 PG 12 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 857TH UT WOS:000297742700004 PM 21987391 ER PT J AU Janssens, ACJW Henneman, L Detmar, SB Khoury, MJ Steyerberg, EW Eijkemans, MJC Mushkudiani, N Oostra, B van Duijn, CM Mackenbach, JP AF Janssens, A. Cecile J. W. Henneman, Lidewij Detmar, Symone B. Khoury, Muin J. Steyerberg, Ewout W. Eijkemans, Marinus J. C. Mushkudiani, Nino Oostra, Ben A. van Duijn, Cornelia M. Mackenbach, Johan P. TI Accuracy of self-reported family history is strongly influenced by the accuracy of self-reported personal health status of relatives SO JOURNAL OF CLINICAL EPIDEMIOLOGY LA English DT Article DE Family history; Accuracy; Self-report assessment; Diabetes; Obesity; Hypertension ID NUTRITION EXAMINATION SURVEY; COMMON CHRONIC DISEASES; PRIMARY-CARE; NATIONAL-HEALTH; PUBLIC-HEALTH; HYPERTENSION; RISK; POPULATION; TOOL; VALIDATION AB Objective: We investigated the accuracy of self-reported family history for diabetes, hypertension, and overweight against two reference standards-family history based on physician-assessed health status of relatives and on self-reported personal health status of relatives. Study Design and Setting: Subjects were participants from the Erasmus Rucphen Family study, an extended family study among descendants of 20 couples who lived between 1850 and 1900 in a southwest region of the Netherlands and their relatives (n = 1,713). Sensitivity and specificity of self-reported family history were calculated. Results: Sensitivity of self-reported family history was 89.2% for diabetes, 92.2% for hypertension, and 78.4% for overweight when family history based on relatives' self-reported personal health status was used as reference and 70.8% for diabetes, 67.4% for hypertension, and 77.3% for overweight when physician-assessed health status of relatives was used. Sensitivity and specificity of self-reported personal health status were 76.8% and 98.8% for diabetes, 38.9% and 98.0% for hypertension, and 80.9% and 75.7% for overweight, respectively. Conclusion: The accuracy of self-reported family history of diabetes and hypertension is strongly influenced by the accuracy of self-reported personal health status of relatives. Raising awareness of personal health status is crucial to ensure the utility of family history for the assessment of risk and disease prevention. (C) 2012 Elsevier Inc. All rights reserved. C1 [Janssens, A. Cecile J. W.; Steyerberg, Ewout W.; Eijkemans, Marinus J. C.; Mushkudiani, Nino; Mackenbach, Johan P.] Erasmus Univ, Med Ctr, Dept Publ Hlth, NL-3015 GE Rotterdam, Netherlands. [Henneman, Lidewij] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Dept Publ & Occupat Hlth, NL-1081 BT Amsterdam, Netherlands. [Detmar, Symone B.] TNO Qual Life, NL-2333 AL Leiden, Netherlands. [Khoury, Muin J.] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA 30333 USA. [Khoury, Muin J.] NCI, Div Canc Control & Populat Sci, Rockville, MD 20852 USA. [Oostra, Ben A.; van Duijn, Cornelia M.] Erasmus Univ, Med Ctr, Dept Epidemiol, Genet Epidemiol Unit, NL-3015 GE Rotterdam, Netherlands. [Oostra, Ben A.; van Duijn, Cornelia M.] Erasmus Univ, Med Ctr, Dept Clin Genet, Genet Epidemiol Unit, NL-3015 GE Rotterdam, Netherlands. RP Janssens, ACJW (reprint author), Erasmus Univ, Med Ctr, Dept Epidemiol, POB 2040, NL-3000 CA Rotterdam, Netherlands. EM a.janssens@erasmusmc.nl RI janssens, cecile/L-1075-2015; OI Janssens, A Cecile/0000-0002-6153-4976; Steyerberg, Ewout/0000-0002-7787-0122 FU Centre for Medical Systems Biology in the framework of the Netherlands Genomics Initiative; Netherlands Organisation for Scientific Research; Erasmus Medical Center; Netherlands Diabetes Foundation; Netherlands Kidney foundation FX The Erasmus Rucphen Family study was supported by grants from the Centre for Medical Systems Biology in the framework of the Netherlands Genomics Initiative, the Netherlands Organisation for Scientific Research, Erasmus Medical Center, and grants from the Netherlands Diabetes Foundation and the Netherlands Kidney foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 33 TC 9 Z9 9 U1 2 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0895-4356 J9 J CLIN EPIDEMIOL JI J. Clin. Epidemiol. PD JAN PY 2012 VL 65 IS 1 BP 82 EP 89 DI 10.1016/j.jclinepi.2011.05.003 PG 8 WC Health Care Sciences & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA 859VH UT WOS:000297903400012 PM 21889309 ER PT J AU Cena, LG Ku, BK Peters, TM AF Cena, Lorenzo G. Ku, Bon Ki Peters, Thomas M. TI Particle Collection Efficiency for Nylon Mesh Screens SO AEROSOL SCIENCE AND TECHNOLOGY LA English DT Article ID DIFFUSION BATTERY; AEROSOL FILTRATION; FILTERS; SIZE; NANOPARTICLES AB Nylon mesh screens, unlike metal screens, are attractive as a collection substrate for nanoparticles because they can be digested or ashed prior to chemical analysis. A theoretical single-fiber efficiency expression developed for wire-mesh screens was evaluated for estimating the collection efficiency of 11-300 nm particles for nylon mesh screens. Pressure drop across the screens, the effect of particle morphology (spherical and highly fractal-like) on collection efficiency, and single-fiber efficiency were evaluated experimentally for three pore sizes (60, 100, and 180 mu m) at three flow rates (2.5, 4, and 6 Lpm). The pressure drop across the screens was found to increase linearly with superficial velocity. The collection efficiency of the screens was found to vary by less than 4% regardless of particle morphology. Single-fiber efficiency calculated from experimental data was in good agreement with that estimated from theory for particles between 40 and 150 nm but deviated from theory for particles outside this size range. New coefficients for the single-fiber efficiency model were identified that minimized the sum of square error (SSE) between the values estimated with the model and those determined experimentally. Compared to the original theory, the SSE calculated using the modified theory was at least one order of magnitude lower for all screens and flow rates with the exception of the 60-mu m pore screens at 2.5 Lpm, where the decrease was threefold. C1 [Cena, Lorenzo G.; Peters, Thomas M.] Univ Iowa, Dept Occupat & Environm Hlth, Iowa City, IA 52242 USA. [Ku, Bon Ki] NIOSH, Ctr Dis Control & Prevent CDC, Cincinnati, OH 45226 USA. RP Peters, TM (reprint author), Univ Iowa, Dept Occupat & Environm Hlth, Res Campus,121 IREH, Iowa City, IA 52242 USA. EM thomas-m-peters@uiowa.edu FU Intramural CDC HHS [CC999999] NR 23 TC 5 Z9 5 U1 3 U2 10 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0278-6826 J9 AEROSOL SCI TECH JI Aerosol Sci. Technol. PY 2012 VL 46 IS 2 BP 214 EP 221 DI 10.1080/02786826.2011.617401 PG 8 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 848PZ UT WOS:000297065900009 PM 26692631 ER PT J AU Diwakar, P Kulkarni, P Birch, ME AF Diwakar, Prasoon Kulkarni, Pramod Birch, M. Eileen TI New Approach for Near-Real-Time Measurement of Elemental Composition of Aerosol Using Laser-Induced Breakdown Spectroscopy SO AEROSOL SCIENCE AND TECHNOLOGY LA English DT Article ID INDUCED PLASMA SPECTROSCOPY; ELECTROSTATIC PRECIPITATOR; CULTURAL-HERITAGE; METAL AEROSOLS; TOXIC METALS; TRACE-METALS; DUST LAYERS; PARTICLES; AIR; SINGLE AB A new approach has been developed for making near-real-time measurement of elemental composition of aerosols using plasma spectroscopy. The method allows preconcentration of miniscule particle mass (pg to ng) directly from the sampled aerosol stream through electrostatic deposition of charged particles (30-900 nm) onto a flat-tip microneedle electrode. The collected material is subsequently ablated from the electrode and monitored by laser-induced breakdown spectroscopy. Atomic emission spectra were collected using a broadband spectrometer with a wavelength range of 200-980 nm. A single-sensor delay time of 1.3 mu s was used in the spectrometer for all elements to allow simultaneous measurement of multiple elements. The system was calibrated for various elements including Cd, Cr, Cu, Mn, Na, and Ti. The absolute mass detection limits for these elements were experimentally determined and found to be in the range of 0.018-5 ng. The electrostatic collection technique has many advantages over other substrate-based methods involving aerosol collection on a filter or its focused deposition using an aerodynamic lens. Because the particle mass is collected over a very small area that is smaller than the spatial extent of the laser-induced plasma, the entire mass is available for analysis. This considerably improves reliability of the calibration and enhances measurement accuracy and precision. Further, the aerosol collection technique involves very low pressure drop, thereby allowing higher sample flow rates with much smaller pumps-a desirable feature for portable instrumentation. Higher flow rates also make it feasible to measure trace element concentrations at part per trillion levels. Detection limits in the range of 18-670 ng m(-3) can be achieved for most of the elements studied at a flow rate of 1.5 L min(-1) with sampling times of 5 min. C1 [Diwakar, Prasoon; Kulkarni, Pramod; Birch, M. Eileen] Ctr Dis Control & Prevent, NIOSH, Cincinnati, OH 45226 USA. RP Kulkarni, P (reprint author), Ctr Dis Control & Prevent, NIOSH, 4676 Columbia Pkwy,MS R7, Cincinnati, OH 45226 USA. EM PSKulkarni@cdc.gov RI Diwakar, Prasoon/E-8689-2010 FU Intramural CDC HHS [CC999999] NR 73 TC 16 Z9 17 U1 6 U2 35 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0278-6826 J9 AEROSOL SCI TECH JI Aerosol Sci. Technol. PY 2012 VL 46 IS 3 BP 316 EP 332 DI 10.1080/02786826.2011.625059 PG 17 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 848QP UT WOS:000297068500006 PM 26692632 ER PT J AU Dong, RG Welcome, DE McDowell, TW AF Dong, Ren G. Welcome, Daniel E. McDowell, Thomas W. TI Some important oversights in the assessment of whole-body vibration exposure based on ISO-2631-1 SO APPLIED ERGONOMICS LA English DT Letter ID LOW-BACK-PAIN; OPERATORS C1 [Dong, Ren G.] NIOSH, E&CTB, HELD, CDC, Morgantown, WV 26505 USA. RP Dong, RG (reprint author), NIOSH, E&CTB, HELD, CDC, 1095 Willowdale Rd,MS 2201, Morgantown, WV 26505 USA. EM rkd6@cdc.gov OI McDowell, Thomas/0000-0002-2416-2210 NR 7 TC 0 Z9 0 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0003-6870 J9 APPL ERGON JI Appl. Ergon. PD JAN PY 2012 VL 43 IS 1 BP 268 EP 269 DI 10.1016/j.apergo.2011.05.005 PG 2 WC Engineering, Industrial; Ergonomics; Psychology, Applied SC Engineering; Psychology GA 827RN UT WOS:000295445700031 PM 21632033 ER PT J AU Damon, IK AF Damon, Inger K. TI Status of human monkeypox: clinical disease, epidemiology and research SO VACCINE LA English DT Article DE Monkeypox; Smallpox ID RISK-FACTORS; WEST-AFRICA; VIRUS; TRANSMISSION; INFECTION; SMALLPOX; OUTBREAK; IMMUNITY; CONGO; INSIGHTS AB Monkeypox, a vesiculo-pustular rash illness, was initially discovered to cause human infection in 1970 through the World Health Organization (WHO)-sponsored efforts of the Commission to Certify Smallpox Eradication in Western Africa and the Congo Basin. The virus had been discovered to cause a nonhuman primate rash illness in 1958, and was thus named monkeypox. The causative agents of monkeypox and smallpox diseases both are species of Orthopoxvirus. Orthopoxvirus monkeypox, when it infects humans as an epizootic, produces a similar clinical picture to that of ordinary human smallpox. Since 1970, extensive epidemiology, virology, ecology and public health research has enabled better characterization of monkeypox virus and the associated human disease. This work reviews the progress in this body of research, and reviews studies of this "newly" emerging zoonotic disease. Published by Elsevier Ltd. C1 CDC, Poxvinis & Rabies Branch, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Dis,Off Infect Dis, Atlanta, GA 30333 USA. RP Damon, IK (reprint author), CDC, Poxvinis & Rabies Branch, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Dis,Off Infect Dis, 1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM idamon@cdc.gov NR 30 TC 17 Z9 17 U1 1 U2 10 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD DEC 30 PY 2011 VL 29 SU 4 BP D54 EP D59 DI 10.1016/j.vaccine.2011.04.014 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 932PN UT WOS:000303303100012 PM 22185831 ER PT J AU Dowdle, WR Cochi, SL AF Dowdle, Walter R. Cochi, Stephen L. TI The principles and feasibility of disease eradication SO VACCINE LA English DT Article DE Eradication; Disease; Global ID POLIO ERADICATION; ECONOMIC-ANALYSIS; LESSONS AB Smallpox eradication framed disease eradication as a monumental public health achievement in global health equity. The principles of disease eradication are encapsulated in a constellation of four conditions: biologic feasibility, adequate public health infrastructure, sufficient funding, and sustained political/societal will. Where the constellation exists, national eradication occurs in the absence of a global initiative. Assessing the feasibility of global eradication requires determining the constellation gaps for nations of all regions and identifying the human and financial resources to fill the gaps. The economic and humanitarian benefits of eradication have strong appeal. Global polio and guinea worm efforts are underway. Regional eradication of measles and rubella has been achieved in the Americas and other diseases have been proposed. Global decisions on disease eradication should include careful consideration of opportunity costs and prioritization of limited global health resources, with the objective of providing the most appropriate, cost-beneficial, and equitable outcome of disease control. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Dowdle, Walter R.] Task Force Global Hlth, Decatur, GA 30030 USA. [Cochi, Stephen L.] Ctr Dis Control & Prevent, Global Immunizat Div, Atlanta, GA 30333 USA. RP Dowdle, WR (reprint author), Task Force Global Hlth, 325 Swanton Way, Decatur, GA 30030 USA. EM WDowdle@taskforce.org NR 27 TC 16 Z9 16 U1 2 U2 24 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD DEC 30 PY 2011 VL 29 SU 4 BP D70 EP D73 DI 10.1016/j.vaccine.2011.04.006 PG 4 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 932PN UT WOS:000303303100015 PM 22188936 ER PT J AU Foster, SO Hughes, K Tarantola, D Glasser, JW AF Foster, Stanley O. Hughes, Kenneth Tarantola, Daniel Glasser, John W. TI Smallpox eradication in Bangladesh, 1972-1976 SO VACCINE LA English DT Article DE Bangladesh; Smallpox; Eradication; Surveillance; Containment ID SURVEILLANCE AB Rahima Banu, the world's last endemic case of severe smallpox, Variola Major, developed rash on October 16, 1975 on Bhola Island, Bangladesh. Achieving eradication in a country destroyed by war challenged the achievement of smallpox eradication. Between January 1, 1972 and December 31, 1975, 225,000 smallpox cases and 45,000 smallpox deaths occurred. Adapting the global smallpox eradication strategies of surveillance, the detection of smallpox cases, and containment, the interruption of smallpox transmission, utilized progress toward three objectives to monitor performance: (1) surveillance - the percent of smallpox infected villages detected within 14 days of the first case of rash, (2) knowledge of the reward - public knowledge of the current amount of the reward for reporting smallpox, and (3) containment - the percent of infected villages interrupting smallpox transmission within 14 days of detection. Failures to achieve these objectives led to the identification and implementation of improved strategies that eventually achieved eradication. Essential to this success was a tripartite partnership of the citizens of Bangladesh, the Bangladesh Ministry of Health, its field staff, and staff and resources mobilized by the World Health Organization. (C) 2011 Published by Elsevier Ltd. C1 [Foster, Stanley O.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Hughes, Kenneth] Natl Univ Singapore, Singapore 117548, Singapore. [Tarantola, Daniel] Univ New S Wales, Sch Publ Hlth & Community Med, Sydney, NSW, Australia. [Glasser, John W.] CDC, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Foster, SO (reprint author), Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. EM sfoster@emory.edu NR 7 TC 0 Z9 0 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD DEC 30 PY 2011 VL 29 SU 4 BP D22 EP D29 DI 10.1016/j.vaccine.2011.06.081 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 932PN UT WOS:000303303100007 PM 22188934 ER PT J AU Krecek, RC Michael, LM Schantz, PM Ntanjana, L Smith, MF Dorny, P Harrison, LJS Grimm, F Praeth, N Willingham, AL AF Krecek, R. C. Michael, L. M. Schantz, P. M. Ntanjana, L. Smith, M. F. Dorny, P. Harrison, L. J. S. Grimm, F. Praeth, N. Willingham, A. L., III TI Prevalence of Taenia solium cysticercosis in swine from a community-based study in 21 villages of the Eastern Cape Province, South Africa (vol 154, pg 38, 2008) SO VETERINARY PARASITOLOGY LA English DT Correction C1 [Krecek, R. C.] Ross Univ, Sch Vet Med, Basseterre, St Kitts & Nevi. [Krecek, R. C.] Univ Johannesburg, Dept Zool, ZA-2006 Auckland Pk, South Africa. [Michael, L. M.] Bayer Pty Ltd, Div Anim Hlth, ZA-1600 Isando, South Africa. [Michael, L. M.] Onderstepoort Vet Inst, ZA-0110 Onderstepoort, South Africa. [Schantz, P. M.] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Infect Dis, Atlanta, GA 30341 USA. [Ntanjana, L.] Vet Serv Eastern Cape Prov, Dept Agr, ZA-5605 Bhisho, Eastern Cape, South Africa. [Smith, M. F.] Agr Res Council, Biometry Unit, ZA-0127 Pretoria, South Africa. [Dorny, P.; Praeth, N.] Inst Trop Med, Dept Anim Hlth, B-2000 Antwerp, Belgium. [Harrison, L. J. S.] Univ Edinburgh, Royal Dick Sch Vet Studies, Div Vet Clin Sci, Ctr Trop Vet Med,Easter Bush Vet Ctr, Roslin EH25 9RG, Midlothian, Scotland. [Grimm, F.] Univ Zurich, Inst Parasitol, CH-8057 Zurich, Switzerland. [Willingham, A. L., III] Univ Copenhagen, Danish Ctr Expt Parasitol, Fac Life Sci, WHO FAO Collaborating Ctr Parasit Zoonoses, DK-1870 Frederiksberg, Denmark. RP Krecek, RC (reprint author), Ross Univ, Sch Vet Med, POB 334, Basseterre, St Kitts & Nevi. EM tkrecek@rossvet.edu.kn NR 1 TC 8 Z9 8 U1 1 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-4017 J9 VET PARASITOL JI Vet. Parasitol. PD DEC 29 PY 2011 VL 183 IS 1-2 BP 198 EP 200 DI 10.1016/j.vetpar.2011.09.033 PG 3 WC Parasitology; Veterinary Sciences SC Parasitology; Veterinary Sciences GA 867JJ UT WOS:000298450400034 ER PT J AU Goldstein, S AF Goldstein, Susan TI Global Routine Vaccination Coverage, 2010 (Reprinted from MMWR, vol 60, pg 1520-1522, 2011) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Goldstein, Susan] WHO, Dept Immunizat Vaccines & Biol, CH-1211 Geneva, Switzerland. [Goldstein, Susan] United Nations Childrens Fund UNICEF, New York, NY USA. [Goldstein, Susan] CDC, Global Immunizat Div, Ctr Global Hlth, Atlanta, GA 30333 USA. RP Goldstein, S (reprint author), WHO, Dept Immunizat Vaccines & Biol, CH-1211 Geneva, Switzerland. EM sgoldstein@cdc.gov NR 10 TC 1 Z9 1 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 28 PY 2011 VL 306 IS 24 BP 2662 EP 2664 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 867VX UT WOS:000298484000009 ER PT J AU Marsden, J Dettinger, L Fraser, G Waller, K Moll, M Weltman, A Nambiar, A Ostroff, S Palumbo, A Beall, B Van Beneden, C Gould, C Stone, N Gupta, N Longenberger, A AF Marsden, Julie Dettinger, Lisa Fraser, George Waller, Kirsten Moll, Maria Weltman, Andre Nambiar, Atmaram Ostroff, Stephen Palumbo, Aimee Beall, Bernard Van Beneden, Chris Gould, Carolyn Stone, Nimalie Gupta, Neil Longenberger, Allison TI Invasive Group A Streptococcus in a Skilled Nursing Facility-Pennsylvania, 2009-2010 (Reprinted from MMWR, vol 60, pg 1445-1449, 2011) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Gupta, Neil; Longenberger, Allison] CDC, EIS, Atlanta, GA 30333 USA. [Marsden, Julie] Montgomery Cty Hlth Dept, Clarksville, TN 37040 USA. [Waller, Kirsten; Moll, Maria; Weltman, Andre; Nambiar, Atmaram; Ostroff, Stephen; Palumbo, Aimee] Penn Dept Hlth, Harrisburg, PA 17108 USA. [Gould, Carolyn; Stone, Nimalie] Natl Ctr Emerging & Zoonot Infect Dis, Div Healthcare Qual Promot, Atlanta, GA USA. RP Longenberger, A (reprint author), CDC, EIS, Atlanta, GA 30333 USA. EM c-alongenb@pa.gov NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 28 PY 2011 VL 306 IS 24 BP 2664 EP 2667 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 867VX UT WOS:000298484000010 ER PT J AU Gerber, SI Cortese, MM Bowen, MD AF Gerber, Susan I. Cortese, Margaret M. Bowen, Michael D. TI Notes From the Field: Outbreaks of Rotavirus Gastroenteritis Among Elderly Adults in Two Retirement Communities-Illinois, 2011 (Reprinted from MMWR, vol 60, pg 1456, 2011) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Cortese, Margaret M.; Bowen, Michael D.] CDC, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Gerber, Susan I.] Cook Cty Dept Publ Health, Oak Forest, IL USA. RP Cortese, MM (reprint author), CDC, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM mcortese@cdc.gov NR 6 TC 0 Z9 0 U1 0 U2 4 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 28 PY 2011 VL 306 IS 24 BP 2667 EP 2668 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 867VX UT WOS:000298484000011 ER PT J AU Jain, V Lucchi, NW Wilson, NO Blackstock, AJ Nagpal, AC Joel, PK Singh, MP Udhayakumar, V Stiles, JK Singh, N AF Jain, Vidhan Lucchi, Naomi W. Wilson, Nana O. Blackstock, Anna J. Nagpal, Avinash C. Joel, Pradeep K. Singh, Mrigendra P. Udhayakumar, Venkatachalam Stiles, Jonathan K. Singh, Neeru TI Plasma levels of angiopoietin-1 and -2 predict cerebral malaria outcome in Central India SO MALARIA JOURNAL LA English DT Article DE Angiopoietins; Cerebral malaria; Pathogenesis; Biomarkers; Receiver operating characteristic analysis ID FALCIPARUM-MALARIA; PLASMODIUM-FALCIPARUM; UNCOMPLICATED MALARIA; AFRICAN CHILDREN; BRAIN; INFLAMMATION; PATHOGENESIS; INDUCTION; DISEASE; CELLS AB Background: The mechanisms underlying the pathogenesis of cerebral malaria (CM) syndrome are not well understood. Previous studies have shown a strong association of inflammatory chemokines, apoptotic markers and angiogenic molecules with CM associated mortality. Recognizing the importance of angiopoietins (ANG) in the pathogenesis of CM, a retrospective investigation was carried out in a hospital cohort of malaria patients with Plasmodium infection in central India to determine if these factors could be suitable markers of CM associated severity. Methods: Patients enrolled in the study were clinically characterized as healthy controls (HC), mild malaria (MM), CM survivors (CMS) and CM non-survivors (CMNS) based on their malaria status and hospital treatment outcome. Plasma ANG-1 and ANG-2 levels were assessed using sandwich ELISA. Receiver operating characteristic (ROC) curve analysis was used to calculate area under the curve (AUC) for each biomarker in order to assess predictive accuracy of individual biomarkers. Results: The plasma levels of ANG-1 were lower in CMS and CMNS compared to control groups (mild malaria and healthy controls) at the time of hospital admission. On the contrary, ANG-2 levels positively correlated with malaria severity and were significantly higher in CMNS. The ratio of ANG-2/ANG-1 was highest in CMNS compared to other groups. Receiver operating characteristic curves revealed that compared to ANG-1 (AUC = 0.35), ANG-2 (AUC = 0.95) and ratio of ANG-2/ANG-1 (AUC = 0.90) were better markers to discriminate CMNS from MM cases. However, they were less specific in predicting fatal outcome amongst CM cases at the time of hospital admission. Conclusion: These results suggest that at the time of admission plasma levels of ANG-2 and ratio of ANG-2/ANG-1 are clinically informative biomarkers to predict fatal CM from MM cases while they have limited usefulness in discriminating fatal CM outcomes in a pool of CM cases in endemic settings of Central India. C1 [Jain, Vidhan; Singh, Neeru] Reg Med Res Ctr Tribals ICMR, Jabalpur 482003, Madhya Pradesh, India. [Lucchi, Naomi W.; Blackstock, Anna J.; Udhayakumar, Venkatachalam] Atlanta Res & Educ Fdn, Decatur, GA USA. [Lucchi, Naomi W.; Blackstock, Anna J.; Udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Ctr Global Hlth,CDC, Atlanta, GA USA. [Wilson, Nana O.; Stiles, Jonathan K.] Morehouse Sch Med, Dept Microbiol Biochem & Immunol, Atlanta, GA 30310 USA. [Nagpal, Avinash C.; Joel, Pradeep K.] Nethaji Subhash Chandra Bose Med Coll Hosp, Jabalpur, Madhya Pradesh, India. [Singh, Mrigendra P.; Singh, Neeru] Natl Inst Malaria Res Field Unit ICMR, Jabalpur, Madhya Pradesh, India. RP Singh, N (reprint author), Reg Med Res Ctr Tribals ICMR, Nagpur Rd, Jabalpur 482003, Madhya Pradesh, India. EM oicmrc@yahoo.co.in FU WHO/UNDP/TDR [A00524]; National Institutes of Health [RR03034]; NIH-NIGM-MBRS [SO6GM08248]; NIH-FIC [R21TW006804-01]; Atlanta Research and Education Foundation Atlanta, GA FX This investigation received financial support from WHO/UNDP/TDR Collaborative Research Grant (A00524) and National Institutes of Health grant numbers NIH-RCMI (RR03034), NIH-NIGM-MBRS (SO6GM08248) and NIH-FIC (R21TW006804-01). NWL and AB were supported by Atlanta Research and Education Foundation Atlanta, GA. NR 30 TC 30 Z9 30 U1 1 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD DEC 23 PY 2011 VL 10 AR 383 DI 10.1186/1475-2875-10-383 PG 7 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 909VS UT WOS:000301594600001 PM 22192385 ER PT J AU Switzer, WM Zheng, HQ Simmons, G Zhou, YC Tang, SH Shankar, A Kapusinszky, B Delwart, EL Heneine, W AF Switzer, William M. Zheng, HaoQiang Simmons, Graham Zhou, Yanchen Tang, Shaohua Shankar, Anupama Kapusinszky, Beatrix Delwart, Eric L. Heneine, Walid TI No Evidence of Murine Leukemia Virus-Related Viruses in Live Attenuated Human Vaccines SO PLOS ONE LA English DT Article ID CHRONIC-FATIGUE-SYNDROME; JAPANESE ENCEPHALITIS; PROSTATE-CANCER; UNITED-STATES; MOUSE DNA; XMRV; CONTAMINATION; PCR; RETROVIRUS; BLOOD AB Background: The association of xenotropic murine leukemia virus (MLV)-related virus (XMRV) in prostate cancer and chronic fatigue syndrome reported in previous studies remains controversial as these results have been questioned by recent data. Nonetheless, concerns have been raised regarding contamination of human vaccines as a possible source of introduction of XMRV and MLV into human populations. To address this possibility, we tested eight live attenuated human vaccines using generic PCR for XMRV and MLV sequences. Viral metagenomics using deep sequencing was also done to identify the possibility of other adventitious agents. Results: All eight live attenuated vaccines, including Japanese encephalitis virus (JEV) (SA-14-14-2), varicella (Varivax), measles, mumps, and rubella (MMR-II), measles (Attenuvax), rubella (Meruvax-II), rotavirus (Rotateq and Rotarix), and yellow fever virus were negative for XMRV and highly related MLV sequences. However, residual hamster DNA, but not RNA, containing novel endogenous gammaretrovirus sequences was detected in the JEV vaccine using PCR. Metagenomics analysis did not detect any adventitious viral sequences of public health concern. Intracisternal A particle sequences closest to those present in Syrian hamsters and not mice were also detected in the JEV SA-14-14-2 vaccine. Combined, these results are consistent with the production of the JEV vaccine in Syrian hamster cells. Conclusions: We found no evidence of XMRV and MLV in eight live attenuated human vaccines further supporting the safety of these vaccines. Our findings suggest that vaccines are an unlikely source of XMRV and MLV exposure in humans and are consistent with the mounting evidence on the absence of these viruses in humans. C1 [Switzer, William M.; Zheng, HaoQiang; Tang, Shaohua; Shankar, Anupama; Heneine, Walid] Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Simmons, Graham; Zhou, Yanchen; Kapusinszky, Beatrix; Delwart, Eric L.] Univ Calif San Francisco, Blood Syst Res Inst, San Francisco, CA 94143 USA. [Simmons, Graham; Zhou, Yanchen; Kapusinszky, Beatrix; Delwart, Eric L.] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA. RP Switzer, WM (reprint author), Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. EM bswitzer@cdc.gov RI Simmons, Graham/G-3523-2012; OI Simmons, Graham/0000-0002-9615-7023; Delwart, Eric/0000-0002-6296-4484 FU US Congress FX As a US government institution, funding is provided by the US Congress. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 36 TC 6 Z9 6 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 22 PY 2011 VL 6 IS 12 AR e29223 DI 10.1371/journal.pone.0029223 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 884DI UT WOS:000299684700042 PM 22216219 ER PT J AU Malarcher, A Dube, S Shaw, L Babb, S Kaufmann, R AF Malarcher, Ann Dube, Shanta Shaw, Lauren Babb, Stephen Kaufmann, Rachel TI Quitting Smoking Among Adults-United States, 2001-2010 (Reprinted from MMWR, vol 60, pg 1513-1519, 2011) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint ID CESSATION TREATMENTS; MORTALITY C1 [Malarcher, Ann; Dube, Shanta; Shaw, Lauren; Babb, Stephen; Kaufmann, Rachel] CDC, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. RP Malarcher, A (reprint author), CDC, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. EM amalarcher@cdc.gov NR 11 TC 2 Z9 2 U1 1 U2 5 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 21 PY 2011 VL 306 IS 23 BP 2554 EP 2557 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 864YQ UT WOS:000298276800008 ER PT J AU Gaviria, D Greenfield, V Bixler, D Thomas, CA Ibrahim, SM Kallen, A Limbago, B Kitchel, B Taylor, TK AF Gaviria, Diana Greenfield, Victoria Bixler, Danae Thomas, Carrie A. Ibrahim, Sherif M. Kallen, Alex Limbago, Brandi Kitchel, Brandon Taylor, Tegwin K. TI Carbapenem-Resistant Klebsiella pneumoniae Associated With a Long-Term-Care Facility-West Virginia, 2009-2011 (Reprinted from MMWR, vol 60, pg 1418, 2011) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint ID INFECTION; OUTBREAK C1 [Taylor, Tegwin K.] CDC, DVM, EIS, Atlanta, GA 30333 USA. [Gaviria, Diana; Greenfield, Victoria] Berkeley Cty Hlth Dept, Martinsburg, WV USA. [Bixler, Danae; Thomas, Carrie A.; Ibrahim, Sherif M.] W Virginia Bur Publ Hlth, Charleston, WV USA. [Kallen, Alex; Limbago, Brandi; Kitchel, Brandon] Natl Ctr Emerging & Zoonot Infect Dis, Div Healthcare Qual Promot, Atlanta, GA USA. RP Taylor, TK (reprint author), CDC, DVM, EIS, Atlanta, GA 30333 USA. EM tktaylor@cdc.gov NR 10 TC 0 Z9 0 U1 1 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 21 PY 2011 VL 306 IS 23 BP 2558 EP 2560 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 864YQ UT WOS:000298276800009 ER PT J AU Kissin, DM Jamieson, DJ Barfield, WD AF Kissin, Dmitry M. Jamieson, Denise J. Barfield, Wanda D. TI Assisted Reproductive Technology Program Reporting SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter C1 [Kissin, Dmitry M.; Jamieson, Denise J.; Barfield, Wanda D.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30333 USA. RP Kissin, DM (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30333 USA. EM DKissin@cdc.gov FU Intramural CDC HHS [CC999999] NR 5 TC 7 Z9 8 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 21 PY 2011 VL 306 IS 23 BP 2564 EP 2564 DI 10.1001/jama.2011.1843 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 864YQ UT WOS:000298276800015 PM 22187275 ER PT J AU Cox, CM Goodin, K Fisher, E Dawood, FS Hamilton, JJ Leparc, GF Gray, M Nelson, L Borse, RH Singleton, JA Reed, C Balish, AL Katz, JM Hopkins, RS Fry, AM AF Cox, Chad M. Goodin, Kate Fisher, Emily Dawood, Fatimah S. Hamilton, Janet J. Leparc, German F. Gray, Monica Nelson, Linda Borse, Rebekah H. Singleton, James A. Reed, Carrie Balish, Amanda L. Katz, Jacqueline M. Hopkins, Richard S. Fry, Alicia M. TI Prevalence of 2009 Pandemic Influenza A (H1N1) Virus Antibodies, Tampa Bay Florida - November-December, 2009 SO PLOS ONE LA English DT Article ID MONOVALENT VACCINATION COVERAGE; UNITED-STATES; RISK-FACTORS; ATTACK RATE; HONG-KONG; INFECTION; SEROCONVERSION; CHALLENGE; SINGAPORE; CHILDREN AB Background: In 2009, a novel influenza virus (2009 pandemic influenza A (H1N1) virus (pH1N1)) caused significant disease in the United States. Most states, including Florida, experienced a large fall wave of disease from September through November, after which disease activity decreased substantially. We determined the prevalence of antibodies due to the pH1N1 virus in Florida after influenza activity had peaked and estimated the proportion of the population infected with pH1N1 virus during the pandemic. Methods: During November-December 2009, we collected leftover serum from a blood bank, a pediatric children's hospital and a pediatric outpatient clinic in Tampa Bay Florida. Serum was tested for pH1N1 virus antibodies using the hemagglutination-inhibition (HI) assay. HI titers >= 40 were considered seropositive. We adjusted seroprevalence results to account for previously established HI assay specificity and sensitivity and employed a simple statistical model to estimate the proportion of seropositivity due to pH1N1 virus infection and vaccination. Results: During the study time period, the overall seroprevalence in Tampa Bay, Florida was 25%, increasing to 30% after adjusting for HI assay sensitivity and specificity. We estimated that 5.9% of the population had vaccine-induced seropositivity while 25% had seropositivity secondary to pH1N1 virus infection. The highest cumulative incidence of pH1N1 virus infection was among children aged 5-17 years (53%) and young adults aged 18-24 years (47%), while adults aged >= 50 years had the lowest cumulative incidence (11-13%) of pH1N1 virus infection. Conclusions: After the peak of the fall wave of the pandemic, an estimated one quarter of the Tampa Bay population had been infected with the pH1N1 virus. Consistent with epidemiologic trends observed during the pandemic, the highest burdens of disease were among school-aged children and young adults. C1 [Cox, Chad M.] Ctr Dis Control & Prevent CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Cox, Chad M.; Dawood, Fatimah S.; Singleton, James A.; Reed, Carrie; Balish, Amanda L.; Katz, Jacqueline M.; Fry, Alicia M.] Natl Ctr Immunizat & Resp Dis NCIRD, Ctr Dis Control & Prevent CDC, Atlanta, GA USA. [Goodin, Kate; Hamilton, Janet J.; Hopkins, Richard S.] Florida Dept Hlth & Rehabil Serv, Bur Epidemiol, Tallahassee, FL 32399 USA. [Leparc, German F.] Florida Blood Serv, St Petersburg, FL USA. [Gray, Monica] Univ S Florida, All Childrens Hosp, St Petersburg, FL 33701 USA. [Nelson, Linda] Univ S Florida, Pediat Clin, Tampa, FL USA. [Borse, Rebekah H.] Natl Ctr Emerging & Zoonot Infect Dis, Ctr Dis Control & Prevent CDC, Atlanta, GA USA. RP Cox, CM (reprint author), Ctr Dis Control & Prevent CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM cyv5@cdc.gov RI Fisher, Elizabeth/B-8802-2011 OI Fisher, Elizabeth/0000-0002-6124-3618 FU Juvaris, Inc; Nobilon-Merck Sharp; Dohme; GlaxoSmithKline FX JMK received support for research studies not related to the work described in this manuscript from Juvaris, Inc, Nobilon-Merck Sharp and Dohme and GlaxoSmithKline in the previous 3 years. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. All other authors have declared that no competing interests exist. NR 39 TC 8 Z9 8 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 20 PY 2011 VL 6 IS 12 AR e29301 DI 10.1371/journal.pone.0029301 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 870JU UT WOS:000298666200022 PM 22206008 ER PT J AU Zheng, HQ Jia, HW Shankar, A Heneine, W Switzer, WM AF Zheng, HaoQiang Jia, Hongwei Shankar, Anupama Heneine, Walid Switzer, William M. TI Detection of Murine Leukemia Virus or Mouse DNA in Commercial RT-PCR Reagents and Human DNAs SO PLOS ONE LA English DT Article ID CHRONIC-FATIGUE-SYNDROME; PROSTATE-CANCER; UNITED-STATES; RETROVIRUS XMRV; NO ASSOCIATION; CONTAMINATION; SEQUENCES; FAILURE; ABSENCE; BLOOD AB The xenotropic murine leukemia virus (MLV)-related viruses (XMRV) have been reported in persons with prostate cancer, chronic fatigue syndrome, and less frequently in blood donors. Polytropic MLVs have also been described in persons with CFS and blood donors. However, many studies have failed to confirm these findings, raising the possibility of contamination as a source of the positive results. One PCR reagent, Platinum Taq polymerase (pol) has been reported to contain mouse DNA that produces false-positive MLV PCR results. We report here the finding of a large number of PCR reagents that have low levels of MLV sequences. We found that recombinant reverse-transcriptase (RT) enzymes from six companies derived from either MLV or avian myeloblastosis virus contained MLV pol DNA sequences but not gag or mouse DNA sequences. Sequence and phylogenetic analysis showed high relatedness to Moloney MLV, suggesting residual contamination with an RT-containing plasmid. In addition, we identified contamination with mouse DNA and a variety of MLV sequences in commercially available human DNAs from leukocytes, brain tissues, and cell lines. These results identify new sources of MLV contamination and highlight the importance of careful pre-screening of commercial specimens and diagnostic reagents to avoid false-positive MLV PCR results. C1 [Zheng, HaoQiang] Natl Ctr HIV AIDS, Branch Lab, Div HIV AIDS Prevent, STD, Atlanta, GA USA. Ctr Dis Control & Prevent, TB Prevent, Atlanta, GA USA. RP Zheng, HQ (reprint author), Natl Ctr HIV AIDS, Branch Lab, Div HIV AIDS Prevent, STD, Atlanta, GA USA. EM bswitzer@cdc.gov FU U.S. Congress through the Centers for Disease Control and Prevention FX The U.S. Congress funded work through the Centers for Disease Control and Prevention. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 30 TC 10 Z9 11 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 20 PY 2011 VL 6 IS 12 AR e29050 DI 10.1371/journal.pone.0029050 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 870JU UT WOS:000298666200017 PM 22205995 ER PT J AU Sandbulte, MR Westgeest, KB Gao, J Xu, XY Klimov, AI Russell, CA Burke, DF Smith, DJ Fouchier, RAM Eichelberger, MC AF Sandbulte, Matthew R. Westgeest, Kim B. Gao, Jin Xu, Xiyan Klimov, Alexander I. Russell, Colin A. Burke, David F. Smith, Derek J. Fouchier, Ron A. M. Eichelberger, Maryna C. TI Discordant antigenic drift of neuraminidase and hemagglutinin in H1N1 and H3N2 influenza viruses SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article ID HONG-KONG INFLUENZA; A VIRUS; ANTIBODY; VACCINE; IMMUNITY; RESISTANCE; EVOLUTION; INFECTION; VARIANTS; SEQUENCE AB Seasonal epidemics caused by influenza virus are driven by antigenic changes (drift) in viral surface glycoproteins that allow evasion from preexisting humoral immunity. Antigenic drift is a feature of not only the hemagglutinin (HA), but also of neuraminidase (NA). We have evaluated the antigenic evolution of each protein in H1N1 and H3N2 viruses used in vaccine formulations during the last 15 y by analysis of HA and NA inhibition titers and antigenic cartography. As previously shown for HA, genetic changes in NA did not always lead to an antigenic change. The noncontinuous pattern of NA drift did not correspond closely with HA drift in either subtype. Although NA drift was demonstrated using ferret sera, we show that these changes also impact recognition by NA-inhibiting antibodies in human sera. Remarkably, a single point mutation in the NA of A/Brisbane/59/2007 was primarily responsible for the lack of inhibition by polyclonal antibodies specific for earlier strains. These data underscore the importance of NA inhibition testing to define antigenic drift when there are sequence changes in NA. C1 [Sandbulte, Matthew R.; Gao, Jin; Eichelberger, Maryna C.] US FDA, Div Viral Prod, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA. [Westgeest, Kim B.; Smith, Derek J.; Fouchier, Ron A. M.] Erasmus MC, Dept Virol, NL-3000 CA Rotterdam, Netherlands. [Xu, Xiyan; Klimov, Alexander I.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Russell, Colin A.; Burke, David F.; Smith, Derek J.] Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England. [Smith, Derek J.] NIH, Fogarty & Int Ctr, Bethesda, MD 20892 USA. RP Eichelberger, MC (reprint author), US FDA, Div Viral Prod, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA. EM maryna.eichelberger@fda.hhs.gov RI burke, david/C-2091-2013; Fouchier, Ron/A-1911-2014; OI Fouchier, Ron/0000-0001-8095-2869; burke, david/0000-0001-8830-3951; Russell, Colin/0000-0002-2113-162X FU Center for Biologics Evaluation and Research; VICI of the Netherlands Organization for Scientific Research; National Institutes of Health [DP1-OD000490-01]; European Union [223498, 278976]; Human Frontier Science Program [P0050/2008]; Royal Society FX We thank Zhiping Ye and Vladimir Lugovtsev for viruses; Robert Webster for plasmids; Olga Zoueva and Arash Hassantoufighi for technical support in preparing reassortant viruses; Theo Bestebroer and Stefan van der Vliet for excellent technical assistance with hemagglutination inhibition assays; and Timothy Straight for provision of human sera. This study used the CamGrid distributed computing resource and was supported by Center for Biologics Evaluation and Research Pandemic Influenza funds (to M.C.E.); a VICI grant of the Netherlands Organization for Scientific Research (to R.A.M.F.); a National Institutes of Health Director's Pioneer Award (DP1-OD000490-01 to D.J.S.), European Union FP7 programs EMPERIE (223498 to D.J.S.) and ANTIGONE (278976 to D.J.S.), a Human Frontier Science Program grant (P0050/2008 to D.J.S.), and a University Research Fellowship from the Royal Society (to C.A.R.). NR 32 TC 51 Z9 52 U1 0 U2 16 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC 20 PY 2011 VL 108 IS 51 BP 20748 EP 20753 DI 10.1073/pnas.1113801108 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 865CW UT WOS:000298289400095 PM 22143798 ER PT J AU Li, Y Li, JN Belisle, S Baskin, CR Tumpey, TM Katze, MG AF Li, Yu Li, Jiangning Belisle, Sarah Baskin, Carole R. Tumpey, Terrence M. Katze, Michael G. TI Differential microRNA expression and virulence of avian, 1918 reassortant, and reconstructed 1918 influenza A viruses SO VIROLOGY LA English DT Article DE Avian H5N1 pandemic influenza virus; microRNA macaque ID PANDEMIC VIRUS; IMMUNE-SYSTEM; MICE; INFLAMMATION; H5N1; CANCER; ROLES; PATHOGENICITY; APOPTOSIS; GENES AB Infections with highly pathogenic H5N1 avian (HPAI) and 1918 pandemic H1N1 influenza viruses cause uncontrolled local and systemic inflammation. The mechanism for this response is poorly understood, despite its importance as a determinant of virulence. Therefore we profiled cellular microRNAs of lung tissue from cynomolgus macaques (Macaca fascicularis) infected with a HPAI and a less pathogenic 1918 H1N1 reassortant virus to understand microRNA contribution to host response. We identified 23 microRNAs associated with the extreme virulence of HPAI, with expression patterns inversely correlated with that of predicted gene targets. Pathway analyses confirmed that these targets were associated with aberrant and uncontrolled inflammatory responses and increased cell death. Importantly, similar microRNAs were associated with lethal 1918 pandemic virus infections in mice. This study suggests that virulence of highly pathogenic influenza viruses may be mediated in part by cellular microRNA through dysregulation of genes critical to the inflammatory process. Published by Elsevier Inc. C1 [Li, Yu; Belisle, Sarah; Katze, Michael G.] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA. [Baskin, Carole R.] Univ Washington, Dept Comparat Med, Seattle, WA 98195 USA. [Katze, Michael G.] Univ Washington, Washington Natl Primate Res Ctr, Seattle, WA 98195 USA. [Li, Jiangning] Inst Syst Biol, Seattle, WA 98109 USA. [Tumpey, Terrence M.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Katze, MG (reprint author), Univ Washington, Dept Microbiol, Box 358070, Seattle, WA 98195 USA. EM honey@u.wasington.edu FU NIH [P51 RR00166, U54 AI081680] FX We thank Janine Bryan and Marcus Korth for critical reading of the manuscript. We also thank Sean Proll, Lynn Law, and Glenn Zhang for their helpful discussion. This work was supported by NIH Grant P51 RR00166 and U54 AI081680. The findings and conclusions in this report are those of the author(s) and do not necessarily represent the views of the funding agency. NR 31 TC 29 Z9 30 U1 1 U2 5 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD DEC 20 PY 2011 VL 421 IS 2 BP 105 EP 113 DI 10.1016/j.virol.2011.09.011 PG 9 WC Virology SC Virology GA 850GU UT WOS:000297183900003 PM 21999992 ER PT J AU Napier, RJ Rafi, W Cheruvu, M Powell, KR Zaunbrecher, MA Bornmann, W Salgame, P Shinnick, TM Kalman, D AF Napier, Ruth J. Rafi, Wasiulla Cheruvu, Mani Powell, Kimberly R. Zaunbrecher, M. Analise Bornmann, William Salgame, Padmini Shinnick, Thomas M. Kalman, Daniel TI Imatinib-Sensitive Tyrosine Kinases Regulate Mycobacterial Pathogenesis and Represent Therapeutic Targets against Tuberculosis (vol 10, pg 475, 2011) SO CELL HOST & MICROBE LA English DT Correction C1 [Powell, Kimberly R.; Kalman, Daniel] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA. [Napier, Ruth J.; Zaunbrecher, M. Analise] Emory Univ, Sch Med, Grad Program Microbiol & Mol Genet, Atlanta, GA 30322 USA. [Zaunbrecher, M. Analise; Shinnick, Thomas M.] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA. [Bornmann, William] Univ Texas Houston, MD Anderson Canc Ctr, Houston, TX 77030 USA. [Rafi, Wasiulla; Salgame, Padmini] UMDNJ New Jersey Med Sch, Dept Med, Newark, NJ 07107 USA. [Rafi, Wasiulla; Cheruvu, Mani] UMDNJ New Jersey Med Sch, Ctr Emerging & Reemerging Pathogens, Newark, NJ 07107 USA. RP Kalman, D (reprint author), Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA. EM dkalman@emory.edu RI Powell, Kimberly/E-6367-2011 OI Powell, Kimberly/0000-0002-3822-526X NR 1 TC 0 Z9 0 U1 1 U2 6 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1931-3128 J9 CELL HOST MICROBE JI Cell Host Microbe PD DEC 15 PY 2011 VL 10 IS 6 BP 635 EP 635 DI 10.1016/j.chom.2011.11.007 PG 1 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA 873OV UT WOS:000298893600013 ER PT J AU Des Jarlais, DC Hagan, H Arasteh, K McKnight, C Semaan, S Perlman, DC AF Des Jarlais, Don C. Hagan, Holly Arasteh, Kamyar McKnight, Courtney Semaan, Salaam Perlman, David C. TI Can intranasal drug use reduce HCV infection among injecting drug users? SO DRUG AND ALCOHOL DEPENDENCE LA English DT Article DE Injecting; Non-injecting; Intranasal drug use; HCV ID HEPATITIS-C VIRUS; NEW-YORK-CITY; RISK-FACTORS; TRANSITION; HEROIN; SEROCONVERSION; INTERVENTIONS; PREVALENCE; PREVENTION; OUTCOMES AB Background: Preventing HCV infection among people who inject drugs is a difficult public health challenge. We examined the potential role of intranasal drug use in reducing HCV acquisition. Methods: Subjects were recruited from IDUs entering the Beth Israel drug detoxification program from 2005 to 2010. A structured interview was administered and serum samples were collected for HCV testing. Results: 726 active injecting drug users were recruited from 2005 to 2010. HCV prevalence was 71%, 90% reported recent heroin injection and 44% reported recent intranasal heroin use. In a multiple logistic regression analysis, being HCV seropositive was associated with more years injecting, Latino ethnicity, previous testing for HCV, and recent injection of speedball, and negatively associated with recent intranasal use of heroin (AOR = 0.52, 95% CI 0.33-0.82) and intranasal use of speedball (AOR = 0.41, 95% CI 0.31-0.80). The association between intranasal heroin use and lower HCV seroprevalance was observed among both new injectors and persons with long injecting histories (16+ years since first injection). Conclusion: Encouraging intranasal use as an alternative to injection among persons currently injecting drugs may be a viable strategy for reducing HCV transmission. (C) 2011 Elsevier Ireland Ltd. All rights reserved. C1 [Des Jarlais, Don C.; Arasteh, Kamyar; McKnight, Courtney; Perlman, David C.] Beth Israel Deaconess Med Ctr, New York, NY 10038 USA. [Hagan, Holly] NYU, New York, NY 10003 USA. [Semaan, Salaam] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Des Jarlais, DC (reprint author), Beth Israel Deaconess Med Ctr, 160 Water St,24th Floor, New York, NY 10038 USA. EM dcdesjarla@aol.com FU National Institutes of Health [DA 03574, 2 P30 DA 11041] FX Funding for this study was provided by the National Institutes of Health Grant # DA 03574 and 2 P30 DA 11041. The National Institutes of Health had no further role in the study design; in the collection, analysis and interpretation of the data; in the writing of the paper; or in the decision to submit the paper for publication. NR 35 TC 4 Z9 4 U1 1 U2 3 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0376-8716 J9 DRUG ALCOHOL DEPEN JI Drug Alcohol Depend. PD DEC 15 PY 2011 VL 119 IS 3 BP 201 EP 206 DI 10.1016/j.drugalcdep.2011.06.020 PG 6 WC Substance Abuse; Psychiatry SC Substance Abuse; Psychiatry GA 868OE UT WOS:000298531800007 PM 21794991 ER PT J AU Wichitnithad, W O'Callaghan, JP Miller, DB Train, BC Callery, PS AF Wichitnithad, Wisut O'Callaghan, James P. Miller, Diane B. Train, Brian C. Callery, Patrick S. TI Time-dependent slowly-reversible inhibition of monoamine oxidase A by N-substituted 1,2,3,6-tetrahydropyridines SO BIOORGANIC & MEDICINAL CHEMISTRY LA English DT Article DE Tetrahydropyridine; Monoamine oxidase; Time-dependent inhibition; Covalent; Sodium borohydride ID NEUROTOXIC AMINE 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; SITE-DIRECTED MUTAGENESIS; FIBRILLARY ACIDIC PROTEIN; SUICIDE INACTIVATION; SUBSTRATE TURNOVER; THERMAL-BEHAVIOR; LIGAND-BINDING; ACTIVE-SITE; OXIDATION; ANALOGS AB A novel class of N-substituted tetrahydropyridine derivatives was found to have multiple kinetic mechanisms of monoamine oxidase A inhibition. Eleven structurally similar tetrahydropyridine derivatives were synthesized and evaluated as inhibitors of MAO-A and MAO-B. The most potent MAO-A inhibitor in the series, 2,4-dichlorophenoxypropyl analog 12, displayed time-dependent mixed noncompetitive inhibition. The inhibition was reversed by dialysis, indicating reversible enzyme inhibition. Evidence that the slow-binding inhibition of MAO-A with 12 involves a covalent bond was gained from stabilizing a covalent reversible intermediate product by reduction with sodium borohydride. The reduced enzyme complex was not reversible by dialysis. The results are consistent with slowly reversible, mechanism-based inhibition. Two tetrahydropyridine analogs that selectively inhibited MAO-A were characterized by kinetic mechanisms differing from the kinetic mechanism of 12. As reversible inhibitors of MAO-A, tetrahydropyridine analogs are at low risk of having an adverse effect of tyramine-induced hypertension. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Wichitnithad, Wisut; Train, Brian C.; Callery, Patrick S.] W Virginia Univ, Dept Basic Pharmaceut Sci, Morgantown, WV 26506 USA. [Wichitnithad, Wisut; Train, Brian C.; Callery, Patrick S.] W Virginia Univ, Mary Babb Randolph Canc Ctr, Morgantown, WV 26506 USA. [Wichitnithad, Wisut] Chulalongkorn Univ, Dept Pharmaceut Technol, Int Program, Bangkok 10330, Thailand. [O'Callaghan, James P.; Miller, Diane B.] NIOSH, Ctr Dis Control & Prevent, Morgantown, WV 26506 USA. RP Callery, PS (reprint author), W Virginia Univ, Dept Basic Pharmaceut Sci, Morgantown, WV 26506 USA. EM pcallery@hsc.wvu.edu RI O'Callaghan, James/O-2958-2013 FU Thailand Research Fund through the Royal Golden Jubilee Ph.D Program [PHD/0217/2548]; mass spectrometry laboratory at West Virginia University FX Financial support was provided by the Thailand Research Fund through the Royal Golden Jubilee Ph.D Program (Grant No. PHD/0217/2548) to W. Wichitnithad and U. Nimmannit. Technical assistance from James D. Thornton and Rachel Brown is appreciated. Support from the mass spectrometry laboratory at West Virginia University is acknowledged. NR 56 TC 6 Z9 6 U1 0 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0968-0896 J9 BIOORGAN MED CHEM JI Bioorg. Med. Chem. PD DEC 15 PY 2011 VL 19 IS 24 BP 7482 EP 7492 DI 10.1016/j.bmc.2011.10.038 PG 11 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry, Organic SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 859ES UT WOS:000297860100019 PM 22078410 ER PT J AU Breen, N Cronin, KA Tiro, JA Meissner, HI McNeel, TS Sabatino, SA Tangka, FK Taplin, SH AF Breen, Nancy Cronin, Kathleen A. Tiro, Jasmin A. Meissner, Helen I. McNeel, Timothy S. Sabatino, Susan A. Tangka, Florence K. Taplin, Stephen H. TI Was the drop in mammography rates in 2005 associated with the drop in hormone therapy use? SO CANCER LA English DT Article DE mammography; hormone therapy; breast cancer; National Health Interview Surveys; women's health; primary care ID BREAST-CANCER INCIDENCE; HEALTH-CARE PROVIDERS; SCREENING MAMMOGRAPHY; UNITED-STATES; INCREASE RECOMMENDATION; COLORECTAL CANCERS; WOMEN; ACCURACY; PROGRAMS; BENEFITS AB BACKGROUND: In 2005, mammography rates in the United States dropped nationally for the first time among age-eligible women. An increased risk of breast cancer related to hormone therapy (HT) use reported in 2002 led to a dramatic drop in its use by 2005. Because current users of HT also tend to have higher mammography rates, the authors examined whether concurrent drops in HT and mammography use were associated. METHODS: Multivariate logistic regression was used to test for an interaction between HT use and survey year, controlling for a range of measurable factors in data from the 2000 and 2005 National Health Interview Surveys (NHIS). RESULTS: Women ages 50 to 64 years were more likely to report a recent mammogram if they also reported more education, a usual source of care, private health insurance, any race except non-Hispanic Asian, talking with an obstetrician/gynecologist or other physician in the past 12 months, or were currently taking HT. Women aged >= 65 years were more likely to report a recent mammogram if they also reported younger age (ages 65-74 years), more education, a usual source of care, having Medicare Part B or other supplemental Medicare insurance, excellent health, any race except non-Hispanic Asian, talking with an obstetrician/gynecologist or other physician in the past 12 months, or were currently taking HT. CONCLUSIONS: The change in HT use was associated with the drop in mammography use for women ages 50 to 64 years but not for women aged >= 65 years. NHIS data explained 70% to 80% of the change in mammography use. Cancer 2011; 117: 5450-60. (C) 2011 American Cancer Society. C1 [Breen, Nancy] Natl Inst, Div Canc Control & Populat Sci, Bethesda, MD USA. [Cronin, Kathleen A.; Taplin, Stephen H.] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. [Tiro, Jasmin A.] Univ Texas SW Med Ctr Dallas, Div Behav & Commun Sci, Dallas, TX 75390 USA. [Meissner, Helen I.] NIH, Off Behav & Social Sci Res, Bethesda, MD 20892 USA. [McNeel, Timothy S.] Informat Management Serv Inc, Rockville, MD USA. [Sabatino, Susan A.; Tangka, Florence K.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA USA. RP Breen, N (reprint author), NCI, Hlth Serv & Econ Branch, Appl Res Program, Execut Plaza N,Room 4005,6130 Executive Blvd,MSC, Rockville, MD 20852 USA. EM breenn@mail.nih.gov OI Tiro, Jasmin/0000-0001-8300-0441 FU Intramural NIH HHS [Z99 CA999999] NR 38 TC 5 Z9 6 U1 0 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0008-543X J9 CANCER-AM CANCER SOC JI Cancer PD DEC 15 PY 2011 VL 117 IS 24 BP 5450 EP 5460 DI 10.1002/cncr.26218 PG 11 WC Oncology SC Oncology GA 855PB UT WOS:000297575600003 PM 21861265 ER PT J AU Price, RA Tiro, JA Saraiya, M Meissner, H Breen, N AF Price, Rebecca Anhang Tiro, Jasmin A. Saraiya, Mona Meissner, Helen Breen, Nancy TI Use of human papillomavirus vaccines among young adult women in the United States: An analysis of the 2008 National Health Interview Survey SO CANCER LA English DT Article DE human papillomavirus; vaccines; cervical cancer; disparities ID AGED 13-17 YEARS; AREA VACCINATION COVERAGE; CANCER-SOCIETY GUIDELINE; CERVICAL-CANCER; QUADRIVALENT VACCINE; HPV INFECTION; IMMUNIZATION; DISPARITIES; EFFICACY; CARE AB BACKGROUND: The Centers for Disease Control and Prevention recommends catch-up administration of human papillomavirus (HPV) vaccines to girls and women ages 13 to 26 who have not been vaccinated previously. In response to debate regarding catch-up vaccination of young adult women, this study examined whether 18- to 26-year-old women most likely to benefit from catch-up vaccination were aware of the HPV vaccine, and initiated the vaccine series by the end of 2008. METHODS: We used data from the 2008 National Health Interview Survey to assess HPV vaccine awareness and use, and reasons for not vaccinating, among women aged 18-26 years (n = 1583). Sociodemographic, health care access, and health history factors associated with vaccine initiation were assessed using multivariate logistic regression. RESULTS: Overall, 11.7% of women aged 18-26 years reported receiving at least 1 dose of the HPV vaccine by the end of 2008. In multivariate analyses, younger age, history of previous HPV infection, unmarried status, health insurance, flu shot in the past year, and receipt of 1 or more recommended lifetime vaccines were significantly associated with HPV vaccine initiation. Two-fifths (39.6%) of unvaccinated women were interested in receiving the HPV vaccine (n 1327). Primary reasons for lack of interest in the vaccine were belief that it was not needed, not knowing enough about it, concerns about safety, and not being sexually active. CONCLUSION: HPV vaccine coverage among young adult women was low, and lower among the uninsured than the insured. Public financing and care provision programs have the potential to expand vaccine coverage among uninsured women, who are at increased risk of cervical cancer. Cancer 2011; 117: 5560-8. (C) 2011 American Cancer Society. C1 [Price, Rebecca Anhang] RAND Corp, Arlington, VA 22202 USA. [Tiro, Jasmin A.] Univ Texas SW Med Ctr Dallas, Dept Clin Sci, Div Behav & Commun Sci, Dallas, TX 75390 USA. [Saraiya, Mona] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA USA. [Meissner, Helen] NIH, Off Behav & Social Sci Res, Bethesda, MD 20892 USA. [Breen, Nancy] NCI, Hlth Serv & Econ Branch, Appl Res Program, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. RP Price, RA (reprint author), RAND Corp, 1200 S Hayes St,Room 7139, Arlington, VA 22202 USA. EM ranhangp@rand.org OI Tiro, Jasmin/0000-0001-8300-0441 FU National Cancer Institute, National Institutes of Health [HHSN261200800001E]; Centers for Disease Control and Prevention FX This study was funded in part with federal funds from the National Cancer Institute, National Institutes of Health (Contract No. HHSN261200800001E). The Cancer Control Module of the National Health Interview Survey was supported by the Centers for Disease Control and Prevention, and the National Cancer Institute, National Institutes of Health. NR 39 TC 30 Z9 30 U1 1 U2 10 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0008-543X J9 CANCER-AM CANCER SOC JI Cancer PD DEC 15 PY 2011 VL 117 IS 24 BP 5560 EP 5568 DI 10.1002/cncr.26244 PG 9 WC Oncology SC Oncology GA 855PB UT WOS:000297575600015 ER PT J AU Wong, CA Berkowitz, Z Dorell, CG Price, RA Lee, J Saraiya, M AF Wong, Charlene A. Berkowitz, Zahava Dorell, Christina G. Price, Rebecca Anhang Lee, Jennifer Saraiya, Mona TI Human papillomavirus vaccine uptake among 9-to 17-year-old girls SO CANCER LA English DT Article DE HPV vaccine; adolescent; vaccine coverage ID AGED 13-17 YEARS; UNITED-STATES; CERVICAL-CANCER; YOUNG-WOMEN; HPV VACCINE; ADOLESCENT IMMUNIZATIONS; PARENTAL RECALL; COVERAGE; ATTITUDES; CARE AB BACKGROUND: Since 2006, the human papillomavirus (HPV) vaccine has been routinely recommended for preadolescent and adolescent girls in the United States. Depending on uptake patterns, HPV vaccine could reduce existing disparities in cervical cancer. METHODS: HPV vaccination status and reasons for not vaccinating were assessed using data from the 2008 National Health Interview Survey. Households with a girl aged 9-17 years were included (N = 2205). Sociodemographic factors and health behaviors associated with vaccine uptake were assessed using multivariate logistic regression. RESULTS: Overall, 2.8% of 9- to 10-year-olds, 14.7% of 11- to 12-year-olds, and 25.4% of 13- to 17-year-olds received at least 1 dose of HPV vaccine; 5.5% of 11- to 12-year-olds and 10.7% of 13- to 17-year-olds received all 3 doses. Factors associated with higher uptake in multivariate analysis included less than high school parental education, well-child check and influenza shot in the past year, and parental familiarity with HPV vaccine. Parents' primary reasons for not vaccinating were beliefs that their daughters did not need vaccination, that their daughters were not sexually active, or had insufficient vaccine knowledge. More parents with private insurance (58.0%) than public (39.8%) or no insurance (39.5%) would pay $360-$500 to vaccinate their daughters. CONCLUSIONS: Less than one quarter of girls aged 9- 17 years had initiated HPV vaccination by the end of 2008. Efforts to increase HPV uptake should focus on girls in the target age group, encourage providers to educate parents, and promote access to reduced-cost vaccines. Cancer 2011; 117: 5612-20. (C) 2011 American Cancer Society. C1 [Wong, Charlene A.; Berkowitz, Zahava; Lee, Jennifer; Saraiya, Mona] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA 30341 USA. [Dorell, Christina G.] Ctr Dis Control & Prevent, Immunizat Serv Div, Atlanta, GA USA. [Price, Rebecca Anhang] RAND Corp, Arlington, VA USA. RP Saraiya, M (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, 4770 Buford Highway,Mailstop K-55, Atlanta, GA 30341 USA. EM msaraiya@cdc.gov FU Centers for Disease Control and Prevention; National Cancer Institute, National Institutes of Health [HHSN261200800001E] FX This study was funded in part by the Centers for Disease Control and Prevention and the National Cancer Institute, National Institutes of Health (Contract No. HHSN261200800001E). NR 47 TC 36 Z9 36 U1 2 U2 17 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0008-543X J9 CANCER-AM CANCER SOC JI Cancer PD DEC 15 PY 2011 VL 117 IS 24 BP 5612 EP 5620 DI 10.1002/cncr.26246 PG 9 WC Oncology SC Oncology GA 855PB UT WOS:000297575600020 PM 21692069 ER PT J AU Harris, JR Lockhart, SR Debess, E Marsden-Haug, N Goldoft, M Wohrle, R Lee, S Smelser, C Park, B Chiller, T AF Harris, J. R. Lockhart, S. R. Debess, E. Marsden-Haug, N. Goldoft, M. Wohrle, R. Lee, S. Smelser, C. Park, B. Chiller, T. TI Cryptococcus gattii in the United States: Clinical Aspects of Infection With an Emerging Pathogen SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID NEOFORMANS VAR GATTII; PACIFIC-NORTHWEST; BRITISH-COLUMBIA; 2 VARIETIES; SEROTYPE-C; EPIDEMIOLOGY; CANADA; SPREAD; PREVALENCE; DIVERSITY AB Background. Cryptococcus gattii (Cg) has caused increasing infections in the US Pacific Northwest (PNW) since 2004. We describe this outbreak and compare clinical aspects of infection in the United States among patients infected with different Cg genotypes. Methods. Beginning in 2005, PNW state health departments conducted retrospective and prospective passive surveillance for Cg infections, including patient interviews and chart reviews; clinical isolates were genotyped at the US Centers for Disease Control and Prevention (CDC). We examined symptom frequency and underlying conditions in US patients with Cg infection and modeled factors associated with death. Results. From 1 December 2004 to July 2011, 96 Cg infections were reported to the CDC. Eighty-three were in patients in or travelers to the PNW, 78 of which were genotypes VGIIa, VGIIb, or VGIIc (outbreak strains). Eighteen patients in and outside the PNW had other molecular type Cg infections (nonoutbreak strains). Patients with outbreak strain infections were more likely than those with nonoutbreak-strain infections to have preexisting conditions (86% vs 31%, respectively; P < .0001) and respiratory symptoms (75% vs 36%, respectively; P = .03) and less likely to have central nervous system (CNS) symptoms (37% vs 90%, respectively; P = .008). Preexisting conditions were associated with increased pneumonia risk and decreased risk of meningitis and CNS symptoms. Nineteen (33%) of 57 patients died. Past-year oral steroid use increased odds of death in multivariate analysis (P = .05). Conclusions. Clinical differences may exist between outbreak-strain (VGIIa, VGIIb, and VGIIc) and nonoutbreak-strain Cg infections in the United States. Clinicians should have a low threshold for testing for Cg, particularly among patients with recent travel to the PNW. C1 [Harris, J. R.] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA 30333 USA. [Debess, E.] Oregon Dept Publ Hlth, Portland, OR USA. [Marsden-Haug, N.; Goldoft, M.; Wohrle, R.] Washington State Dept Hlth, Tumwater, WA USA. [Lee, S.] Univ New Mexico, Albuquerque, NM 87131 USA. [Smelser, C.] New Mexico Dept Hlth, Santa Fe, NM USA. RP Harris, JR (reprint author), Ctr Dis Control & Prevent, Mycot Dis Branch, 1600 Clifton Rd NE,MS C-09, Atlanta, GA 30333 USA. EM ggt5@cdc.gov NR 33 TC 76 Z9 79 U1 4 U2 10 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD DEC 15 PY 2011 VL 53 IS 12 BP 1188 EP 1195 DI 10.1093/cid/cir723 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 851OF UT WOS:000297279700005 PM 22016503 ER PT J AU Bao, CJ Guo, XL Qi, X Hu, JL Zhou, MH Varma, JK Cui, LB Yang, HT Jiao, YJ Klena, JD Li, LX Tao, WY Li, X Chen, Y Zhu, Z Xu, K Shen, AH Wu, T Peng, HY Li, ZF Shan, J Shi, ZY Wang, H AF Bao, Chang-jun Guo, Xi-ling Qi, Xian Hu, Jian-li Zhou, Ming-hao Varma, Jay K. Cui, Lun-biao Yang, Hai-tao Jiao, Yong-jun Klena, John D. Li, Lu-xun Tao, Wen-yuan Li, Xian Chen, Yin Zhu, Zheng Xu, Ke Shen, Ai-hua Wu, Tao Peng, Hai-yan Li, Zhi-feng Shan, Jun Shi, Zhi-yang Wang, Hua TI A Family Cluster of Infections by a Newly Recognized Bunyavirus in Eastern China, 2007: Further Evidence of Person-to-Person Transmission SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID RIFT-VALLEY FEVER; NOSOCOMIAL TRANSMISSION; HEMORRHAGIC-FEVER; ANDES VIRUS; ARGENTINA; OUTBREAK; KENYA AB Background. Seven persons in one family living in eastern China developed fever and thrombocytopenia during May 2007, but the initial investigation failed to identify an infectious etiology. In December 2009, a novel bunyavirus (designated severe fever with thrombocytopenia syndrome bunyavirus [SFTSV]) was identified as the cause of illness in patients with similar clinical manifestations in China. We reexamined this family cluster for SFTSV infection. Methods. We analyzed epidemiological and clinical data for the index patient and 6 secondary patients. We tested stored blood specimens from the 6 secondary patients using real time reverse transcription polymerase chain reaction (RT-PCR), viral culture, genetic sequencing, micro-neutralization assay (MNA), and indirect immunofluorescence assay (IFA). Results. An 80-year-old woman with fever, leucopenia, and thrombocytopenia died on 27 April 2007. Between 3 and 7 May 2007, another 6 patients from her family were admitted to a local county hospital with fever and other similar symptoms. Serum specimens collected in 2007 from these 6 patients were positive for SFTS viral RNA through RT-PCR and for antibody to SFTSV through MNA and IFA. SFTSV was isolated from 1 preserved serum specimen. The only shared characteristic between secondary patients was personal contact with the index patient; none reported exposure to suspected animals or vectors. Conclusions. Clinical and laboratory evidence confirmed that the patients of fever and thrombocytopenia occurring in a family cluster in eastern China in 2007 were caused by a newly recognized bunyavirus, SFTSV. Epidemiological investigation strongly suggests that infection of secondary patients was transmitted to family members by personal contact. C1 [Zhou, Ming-hao; Yang, Hai-tao; Wang, Hua] Jiangsu Prov Ctr Dis Control & Prevent, Nanjing 210009, Jiangsu Provinc, Peoples R China. [Bao, Chang-jun; Qi, Xian; Hu, Jian-li; Xu, Ke; Li, Zhi-feng; Shan, Jun] Jiangsu Prov Ctr Dis Control & Prevent, Dept Acute Infect Dis Control & Prevent, Nanjing, Peoples R China. [Guo, Xi-ling; Cui, Lun-biao; Jiao, Yong-jun; Li, Xian; Chen, Yin; Zhu, Zheng; Wu, Tao; Peng, Hai-yan; Shi, Zhi-yang] Jiangsu Prov Ctr Dis Control & Prevent, Pathogen Microorganism Inst, Nanjing, Peoples R China. [Varma, Jay K.; Klena, John D.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Li, Lu-xun; Shen, Ai-hua] Lishui Cty Ctr Dis Control & Prevent, Nanjing, Peoples R China. [Tao, Wen-yuan] Peoples Hosp Lishui Cty, Nanjing, Peoples R China. RP Wang, H (reprint author), Jiangsu Prov Ctr Dis Control & Prevent, 172 Jiangsu Rd, Nanjing 210009, Jiangsu Provinc, Peoples R China. EM hua@jscdc.cn FU Ministry of Science and Technology [2009ZX10004-904]; Ministry of Health FX This work was supported by China Mega Project for Infectious Disease [2009ZX10004-904] from Ministry of Science and Technology and Ministry of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of manuscript. NR 17 TC 91 Z9 114 U1 2 U2 16 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD DEC 15 PY 2011 VL 53 IS 12 BP 1208 EP 1214 DI 10.1093/cid/cir732 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 851OF UT WOS:000297279700008 PM 22028437 ER PT J AU MacNeil, JR Cohn, AC Farley, M Mair, R Baumbach, J Bennett, N Gershman, K Harrison, LH Lynfield, R Petit, S Reingold, A Schaffner, W Thomas, A Coronado, F Zell, ER Mayer, LW Clark, TA Messonnier, NE AF MacNeil, Jessica R. Cohn, Amanda C. Farley, Monica Mair, Raydel Baumbach, Joan Bennett, Nancy Gershman, Ken Harrison, Lee H. Lynfield, Ruth Petit, Susan Reingold, Arthur Schaffner, William Thomas, Ann Coronado, Fatima Zell, Elizabeth R. Mayer, Leonard W. Clark, Thomas A. Messonnier, Nancy E. TI Current Epidemiology and Trends in Invasive Haemophilus influenzae Disease-United States, 1989-2008 SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID B HIB DISEASE; CHANGING EPIDEMIOLOGY; CONJUGATE VACCINE; CHILDREN; INFECTIONS; SURVEILLANCE; SEROTYPE; ADULTS; ERA; REPLACEMENT AB Background. With the introduction of Haemophilus influenzae serotype b (Hib) conjugate vaccines, there has been a dramatic reduction of Hib disease in young children and the epidemiological trends of invasive H. influenzae have shifted. Methods. Data were collected from active surveillance for invasive H. influenzae disease conducted through Active Bacterial Core surveillance sites during 1989-2008. Results. During 1999-2008, the estimated mean annual incidence of H. influenzae infection was 1.62 cases per 100 000 population; 15.3% of cases were fatal. Incidence was higher among adults aged >= 65 years, compared with other age groups. The largest burden of disease among children aged,5 years was in infants aged <1 year; many of these cases occurred during the first month of life in preterm or low-birth weight infants. An estimated 10% of the total burden of disease among children aged <5 years occurred in American Indian and Alaska Native children. During 1989-2008, 7559 cases of H. influenzae disease were reported from Active Bacterial Core surveillance sites. Small increases in the incidence of serotypes a, e, and f were observed during 1989-2008. The largest of these increases was in serotype f and was primarily among adults aged >= 18 years. Conclusions. Since the introduction of Hib conjugate vaccines, the incidence of invasive disease caused by H. influenzae in the United States has decreased dramatically; however, a considerable burden of non-Hib disease is still present in the oldest and youngest age groups. There is no evidence of substantial replacement disease with non-b serotypes in young children in the United States. C1 [MacNeil, Jessica R.; Cohn, Amanda C.; Mair, Raydel; Coronado, Fatima; Zell, Elizabeth R.; Mayer, Leonard W.; Clark, Thomas A.; Messonnier, Nancy E.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Bacterial Dis, Atlanta, GA 30333 USA. [Farley, Monica] Emory Univ, Sch Med, Dept Med, Atlanta, GA USA. [Farley, Monica] Atlanta VA Med Ctr, Atlanta, GA USA. [Baumbach, Joan] New Mexico Dept Hlth, Santa Fe, NM USA. [Bennett, Nancy] New York State Dept Hlth, Albany, NY 12237 USA. [Gershman, Ken] Colorado Dept Publ Hlth & Environm, Denver, CO USA. [Harrison, Lee H.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA. [Lynfield, Ruth] Minnesota Dept Hlth, St Paul, MN USA. [Petit, Susan] Connecticut Dept Publ Hlth, Hartford, CT USA. [Reingold, Arthur] Univ Calif, Sch Publ Hlth, Berkeley, CA USA. [Schaffner, William] Vanderbilt Univ, Sch Med, Dept Prevent Med, Nashville, TN 37212 USA. [Thomas, Ann] Oregon Dept Human Serv, Portland, OR USA. RP MacNeil, JR (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Bacterial Dis, 1600 Clifton Rd NE,MS C-09, Atlanta, GA 30333 USA. EM jmacneil@cdc.gov FU CDC [CI05-026]; GlaxoSmithKline; Pfizer; Novartis; Sanofi-Pasteur FX The ABCs sites received funding from the CDC Emerging Infections Program cooperative agreement (CI05-026).; LH has received consulting fees and honoraria from GlaxoSmithKline, Pfizer, Novartis, and Sanofi-Pasteur and grant support from Sanofi-Pasteur. All other authors: no conflicts. NR 27 TC 56 Z9 58 U1 0 U2 5 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD DEC 15 PY 2011 VL 53 IS 12 BP 1230 EP 1236 DI 10.1093/cid/cir735 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 851OF UT WOS:000297279700011 PM 22080119 ER PT J AU Doshi, S Kamimoto, L Finelli, L Perez, A Reingold, A Gershman, K Yousey-Hindes, K Arnold, K Ryan, P Lynfield, R Morin, C Baumbach, J Hancock, EB Bennett, NM Zansky, S Thomas, A Schaffner, W Fry, AM AF Doshi, Saumil Kamimoto, Laurie Finelli, Lyn Perez, Alejandro Reingold, Arthur Gershman, Ken Yousey-Hindes, Kimberly Arnold, Kathryn Ryan, Patricia Lynfield, Ruth Morin, Craig Baumbach, Joan Hancock, Emily B. Bennett, Nancy M. Zansky, Shelley Thomas, Ann Schaffner, William Fry, Alicia M. TI Description of Antiviral Treatment Among Adults Hospitalized With Influenza Before and During the 2009 Pandemic: United States, 2005-2009 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID A H1N1 VIRUS; NEURAMINIDASE INHIBITORS; OSELTAMIVIR TREATMENT; SEASONAL INFLUENZA; PREGNANT-WOMEN; INFECTION; A(H1N1); CHINA; OUTCOMES AB Methods. The Emerging Infections Program conducts active population-based surveillance for persons hospitalized with community-acquired, laboratory-confirmed influenza in 10 states. We analyzed data collected via medical record review of patients aged >= 18 years admitted during prepandemic (1 October 2005 through 14 April 2009) and pandemic (15 April 2009 through 31 December 2009) time frames. Results. Of 5943 adults hospitalized with influenza in prepandemic seasons, 3235 (54%) received antiviral treatment, compared with 4055 (82%) of 4966 during the pandemic. Forty-one (22%) of 187 pregnant women received antiviral treatment in prepandemic seasons, compared with 369 (86%) of 430 during the pandemic. Pregnancy was a negative predictor of antiviral treatment before the pandemic (adjusted odds ratio [aOR], 0.24; 95% confidence interval [CI], .16-.35) but was independently associated with treatment during the pandemic (aOR, 1.97; 95% CI, 1.32-2.96). Antiviral treatment among adults hospitalized > 2 days after illness onset increased from 43% before the pandemic to 79% during the pandemic (P < .001). Conclusions. Antiviral treatment of hospitalized adults increased during the pandemic, especially among pregnant women. This suggests that many clinicians followed published guidance to treat hospitalized adults with antiviral agents. However, compliance with antiviral recommendations could be improved. C1 [Doshi, Saumil; Kamimoto, Laurie; Finelli, Lyn; Perez, Alejandro; Fry, Alicia M.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA. [Doshi, Saumil] Epidem Intelligence Serv, Atlanta, GA USA. [Arnold, Kathryn] Georgia Emerging Infect Program, Atlanta, GA USA. [Reingold, Arthur] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA. [Gershman, Ken] Colarado Dept Publ Hlth & Environm, Denver, CO USA. [Yousey-Hindes, Kimberly] Connecticut Emerging Infect Program, New Haven, CT USA. [Ryan, Patricia] Maryland Dept Hlth & Mental Hyg, Baltimore, MD USA. [Lynfield, Ruth; Morin, Craig] Minnesota Dept Hlth, St Paul, MN USA. [Baumbach, Joan; Hancock, Emily B.] New Mexico Dept Hlth, Santa Fe, NM USA. [Bennett, Nancy M.] Univ Rochester, New York, NY USA. [Zansky, Shelley] New York State Dept Hlth, Albany, NY USA. [Thomas, Ann] Oregon Publ Hlth Div, Portland, OR USA. [Schaffner, William] Vanderbilt Univ, Sch Med, Dept Prevent Med, Nashville, TN 37212 USA. RP Fry, AM (reprint author), Ctr Dis Control & Prevent, Influenza Div, CDC MS A-38,1600 Clifton Rd NE,MS A34, Atlanta, GA 30333 USA. EM afry@cdc.gov OI Yousey-Hindes, Kimberly/0000-0002-9418-575X FU CDC FX This work was supported by the CDC. No outside finding was used for this study. NR 32 TC 27 Z9 27 U1 1 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 15 PY 2011 VL 204 IS 12 BP 1848 EP 1856 DI 10.1093/infdis/jir648 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 848QU UT WOS:000297069100007 PM 22013219 ER PT J AU Bachmann, LH Hobbs, MM Sena, AC Sobel, JD Schwebke, JR Krieger, JN McClelland, RS Workowski, KA AF Bachmann, Laura H. Hobbs, Marcia M. Sena, Arlene C. Sobel, Jack D. Schwebke, Jane R. Krieger, John N. McClelland, R. Scott Workowski, Kimberly A. TI Trichomonas vaginalis Genital Infections: Progress and Challenges SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; SEXUALLY-TRANSMITTED INFECTIONS; RANDOMIZED CLINICAL-TRIAL; SINGLE-DOSE TREATMENT; HIV-NEGATIVE WOMEN; RISK-FACTORS; METRONIDAZOLE; TINIDAZOLE; PREVALENCE; URETHRITIS AB Trichomonas vaginalis (TV) infection is the most prevalent curable sexually transmitted infection in the United States and worldwide. Most TV infections are asymptomatic, and the accurate diagnosis of this infection has been limited by lack of sufficiently sensitive and specific diagnostic tests, particularly for men. To provide updates for the 2010 Centers for Disease Control and Prevention's Sexually Transmitted Diseases Treatment Guidelines, a PubMed search was conducted of all TV literature published from 9 January 2004 through 24 September 2008. Approximately 175 pertinent abstracts and articles were reviewed and discussed with national experts. This article describes advances in TV diagnostics which have led to an improved understanding of the epidemiology of this pathogen, as well as potential biologic and epidemiological interactions between TV and human immunodeficiency virus (HIV). New data on treatment outcomes, metronidazole-resistant TV, management of nitroimidazole-allergic patients, frequency of recurrent TV infection following treatment, and screening considerations for TV in certain populations are also presented. C1 [Bachmann, Laura H.] Wake Forest Univ Hlth Sci, Infect Dis Sect, Winston Salem, NC 27157 USA. [Bachmann, Laura H.] WG Bill Hefner Med Ctr, Infect Dis Sect, Salisbury, CT USA. [Sena, Arlene C.] Univ N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC USA. [Hobbs, Marcia M.] Univ N Carolina, Dept Microbiol, Chapel Hill, NC USA. [Hobbs, Marcia M.] Univ N Carolina, Dept Immunol, Chapel Hill, NC USA. [Sobel, Jack D.] Wayne State Univ, Dept Med, Div Infect Dis, Detroit, MI 48202 USA. [Schwebke, Jane R.] Univ Alabama, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA. [Krieger, John N.] Univ Washington, Dept Urol, Seattle, WA 98195 USA. [Krieger, John N.] VA Puget Sound Hlth Care Syst, Dept Urol, Seattle, WA USA. [McClelland, R. Scott] Univ Washington, Dept Med, Seattle, WA USA. [McClelland, R. Scott] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. [McClelland, R. Scott] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA. [Workowski, Kimberly A.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Workowski, Kimberly A.] Emory Univ, Dept Med, Div Infect Dis, Atlanta, GA 30322 USA. RP Bachmann, LH (reprint author), Wake Forest Univ Hlth Sci, Infect Dis Sect, Med Ctr Blvd, Winston Salem, NC 27157 USA. EM lbachman@wfubmc.edu FU Centers for Disease Control and Prevention FX This article was published as part of a supplement entitled "Sexually Transmitted Disease Treatment Guidelines" sponsored by the Centers for Disease Control and Prevention. NR 73 TC 33 Z9 37 U1 0 U2 12 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD DEC 15 PY 2011 VL 53 SU 3 BP S160 EP S172 DI 10.1093/cid/cir705 PG 13 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 847MY UT WOS:000296978200012 PM 22080269 ER PT J AU Datta, SD Saraiya, M AF Datta, S. Deblina Saraiya, Mona TI Cervical Cancer Screening Among Women Who Attend Sexually Transmitted Diseases (STD) Clinics: Background Paper for 2010 STD Treatment Guidelines SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID HUMAN-PAPILLOMAVIRUS INFECTION; RANDOMIZED CONTROLLED-TRIAL; CONVENTIONAL CYTOLOGY; UNITED-STATES; DNA TESTS; SMEARS AB Methods. Key questions were identified with assistance from an expert panel. Reviews of the literature were conducted using the PubMed computerized database and shared with the panel. Updated information was incorporated in the 2010 CDC STD Treatment Guidelines. Results. We recommend that STD clinics offering cervical screening services screen and treat women according to guidelines by the American College of Obstetrics and Gynecology, the American Cancer Society, the US Preventive Services Task Force, and the American Society for Colposcopists and Cervical Pathologists. New to the 2010 guidelines are higher age for initiating cervical screening (age >= 21 years) and less frequent intervals of screening (at least every 3 years). New recommendations include new technologies, such as liquid-based cytology and high-risk human papillomavirus (HPV) DNA tests. Liquid-based technologies are not recommended over conventional testing. HPV DNA tests are recommended as adjunct tests and with new indications for use in cervical screening and management. Stronger recommendations were issued for STD clinics offering cervical screening services to have protocols in place for follow-up of test results and referral (eg, colposcopy). Conclusions. Important additions to the 2010 STD Treatment Guidelines include information on updated algorithms for screening and management of women and recommendations for use of liquid-based cytology and high-risk HPV testing. C1 [Datta, S. Deblina] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30333 USA. [Saraiya, Mona] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA USA. RP Datta, SD (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30333 USA. FU Centers for Disease Control and Prevention FX This article was published as part of a supplement entitled "Sexually Transmitted Disease Treatment Guidelines" sponsored by the Centers for Disease Control and Prevention. NR 31 TC 3 Z9 3 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD DEC 15 PY 2011 VL 53 SU 3 BP S153 EP S159 DI 10.1093/cid/cir704 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 847MY UT WOS:000296978200011 PM 22080268 ER PT J AU Dunne, EF Friedman, A Datta, SD Markowitz, LE Workowski, KA AF Dunne, Eileen F. Friedman, Allison Datta, S. Deblina Markowitz, Lauri E. Workowski, Kimberly A. TI Updates on Human Papillomavirus and Genital Warts and Counseling Messages From the 2010 Sexually Transmitted Diseases Treatment Guidelines SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID CERVICAL INTRAEPITHELIAL NEOPLASIA; ABNORMAL PAPANICOLAOU SMEARS; RANDOMIZED CONTROLLED-TRIAL; USE PROMOTES REGRESSION; IN-DEPTH INTERVIEWS; NATURAL-HISTORY; CONDOM USE; QUADRIVALENT VACCINE; PSYCHOLOGICAL IMPACT; UNIVERSITY-STUDENTS AB Methods. Key questions were identified with assistance from an expert panel, and systematic reviews of the literature were conducted searching the English-language literature of the PubMed computerized database (US National Library of Medicine). The available evidence was reviewed, and new information was incorporated in the 2010 CDC STD Treatment Guidelines. Results. Two HPV vaccines are now available, the quadrivalent HPV vaccine and the bivalent HPV vaccine; either vaccine is recommended routinely for girls aged 11 or 12 years. The quadrivalent HPV vaccine may be given to boys and men aged 9-26 years. A new patient-applied treatment option for genital warts, sinecatechins 15% ointment, is available and recommended for treatment of external genital warts. This product is a mixture of active ingredients (catechins) from green tea. Finally, updated counseling guidelines and messages about HPV, genital warts, and cervical cancer are included. Conclusions. This manuscript highlights updates to the 2010 CDC STD Treatment Guidelines for HPV and genital warts. Important additions to the 2010 STD Treatment Guidelines include information on prophylactic HPV vaccine recommendations, new patient-applied treatment options for genital warts, and counseling messages for patients on HPV, genital warts, cervical cancer screening, and HPV tests. C1 [Dunne, Eileen F.; Friedman, Allison; Datta, S. Deblina; Markowitz, Lauri E.; Workowski, Kimberly A.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA USA. [Workowski, Kimberly A.] Emory Univ, Dept Infect Dis, Atlanta, GA 30322 USA. RP Dunne, EF (reprint author), CDC, Div STD Prevent, 1600 Clifton Rd,MS E-02, Atlanta, GA 30333 USA. EM dde9@cdc.gov FU Centers for Disease Control and Prevention FX This article was published as part of a supplement entitled "Sexually Transmitted Disease Treatment Guidelines" sponsored by the Centers for Disease Control and Prevention. NR 67 TC 14 Z9 14 U1 1 U2 7 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD DEC 15 PY 2011 VL 53 SU 3 BP S143 EP S152 DI 10.1093/cid/cir703 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 847MY UT WOS:000296978200010 PM 22080267 ER PT J AU Ghanem, KG Workowski, KA AF Ghanem, Khalil G. Workowski, Kimberly A. TI Management of Adult Syphilis SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID HIV-INFECTED PATIENTS; BENZATHINE PENICILLIN-G; CEREBROSPINAL-FLUID ABNORMALITIES; IMMUNODEFICIENCY-VIRUS-INFECTION; RAPID PLASMA REAGIN; TREPONEMA-PALLIDUM; AZITHROMYCIN RESISTANCE; ANTIRETROVIRAL THERAPY; MACROLIDE RESISTANCE; ASYMPTOMATIC NEUROSYPHILIS AB There are several important unanswered key questions in the management of adult syphilis. A systematic literature review was conducted and tables of evidence were constructed to answer these important questions. A single dose of 2.4 million units of benzathine penicillin G remains the drug of choice for managing early syphilis. Enhanced antibiotic therapy has not been shown to improve treatment outcomes, regardless of human immunodeficiency virus (HIV) status. Although additional data on the efficacy of azithromycin in treating early syphilis have emerged, reported increases in the prevalence of a mutation associated with azithromycin resistance precludes a recommendation for its routine use. Cerebrospinal fluid (CSF) examination should be performed in all persons with serologic evidence of syphilis infection and neurologic symptoms. In those persons with early syphilis who do not achieve a >= 4-fold serologic decline in their rapid plasma reagin (RPR) titers 6-12 months after adequate therapy and those with late latent infection who do not achieve a similar decline within 12-24 months, CSF examination should be considered. Among HIV-infected persons, CSF examination among all those with asymptomatic late latent syphilis is not recommended owing to lack of evidence that demonstrates clinical benefit. HIV-infected persons with syphilis of any stages whose RPR titers are >= 1:32 and/or whose CD4 cell counts are < 350 cells/mm(3) may be at increased risk for asymptomatic neurosyphilis. If CSF pleocytosis is evident at initial CSF examination, these examinations should be repeated every 6 months until the cell count is normal. Several important questions regarding the management of syphilis remain unanswered and should be a priority for future research. C1 [Workowski, Kimberly A.] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. [Workowski, Kimberly A.] Emory Univ, Atlanta, GA 30322 USA. [Ghanem, Khalil G.] Johns Hopkins Univ, Div Infect Dis, JHUBMC, Sch Med, Baltimore, MD 21224 USA. RP Ghanem, KG (reprint author), Johns Hopkins Univ, Div Infect Dis, JHUBMC, Sch Med, 4940 Eastern Ave,B3N, Baltimore, MD 21224 USA. EM kghanem@jhmi.edu FU Centers for Disease Control and Prevention FX This article was published as part of a supplement entitled "Sexually Transmitted Disease Treatment Guidelines" sponsored by the Centers for Disease Control and Prevention. NR 74 TC 28 Z9 34 U1 1 U2 8 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD DEC 15 PY 2011 VL 53 SU 3 BP S110 EP S128 DI 10.1093/cid/cir701 PG 19 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 847MY UT WOS:000296978200008 PM 22080265 ER PT J AU Workowski, KA Berman, SM AF Workowski, Kimberly A. Berman, Stuart M. TI Centers for Disease Control and Prevention Sexually Transmitted Disease Treatment Guidelines SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID ACID AMPLIFICATION TESTS; HEPATITIS-C VIRUS; TRICHOMONAS-VAGINALIS; EARLY SYPHILIS; LYMPHOGRANULOMA-VENEREUM; CHLAMYDIA-TRACHOMATIS; BACTERIAL VAGINOSIS; CEREBROSPINAL-FLUID; UNITED-STATES; PENICILLIN-G C1 [Workowski, Kimberly A.] Ctr Dis Control & Prevent, Div Sexually Transmitted Dis Prevent, Natl Ctr HIV AIDS Viral Hepatitis Sexually Transm, Atlanta, GA 30333 USA. [Workowski, Kimberly A.] Emory Univ, Dept Med, Div Infect Dis, Atlanta, GA 30322 USA. RP Workowski, KA (reprint author), Ctr Dis Control & Prevent, Div Sexually Transmitted Dis Prevent, Natl Ctr HIV AIDS Viral Hepatitis Sexually Transm, 1600 Clifton Rd,Mailstop E02, Atlanta, GA 30333 USA. EM kgw2@cdc.gov FU Centers for Disease Control and Prevention FX This article was published as part of a supplement entitled "Sexually Transmitted Disease Treatment Guidelines" sponsored by the Centers for Disease Control and Prevention. NR 45 TC 28 Z9 31 U1 0 U2 6 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD DEC 15 PY 2011 VL 53 SU 3 BP S59 EP S63 DI 10.1093/cid/cir694 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 847MY UT WOS:000296978200001 PM 22080270 ER PT J AU Mei, JV Kennedy, M Linley, L Hanson, D Schiffer, J Ethridge, S Branson, B AF Mei, Joanne V. Kennedy, Meredith Linley, Laurie Hanson, Debra Schiffer, Jarad Ethridge, Steven Branson, Bernard TI Standardization and Monitoring of Laboratory Performance and Quality Assurance by Use of the Less-Sensitive HIV Incidence Assay: Seven Years of Results SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV less-sensitive incidence assay; method performance; proficiency testing; quality assurance; recent infection testing algorithms; serological testing algorithm for recent HIV seroconversion; standardization ID CAPTURE ENZYME-IMMUNOASSAY; TESTING ALGORITHM; TYPE-1 SEROCONVERSION; DISTINGUISH RECENT; SAN-FRANCISCO; UNITED-STATES; INFECTION; STRATEGY; AFRICA; SEROINCIDENCE AB Background: The Performance Evaluation Program for HIV-1 incidence tests provided quality assurance services to laboratories conducting the serological testing algorithm for recent HIV seroconversion by use of a modified less-sensitive version of the Vironostika HIV-1 MicroElisa System assay. We report on the performance of the assay using proficiency testing and quality control materials tested from 2001 to 2008. Methods: Two sets of 5 blinded serum panels using common calibration and quality control materials were tested. The mean, standard deviation, and coefficient of variation were calculated. Results were analyzed for misclassifications: false recent HIV infection errors (long-term infection classified as HIV infection less than 1 year), false long-term infection errors (HIV infection less than 1 year classified as long-term infection), and differences in standardized optical density means and variances over time. Results: The false recent error rate was 1.26% (n = 2219). The false long-term error rate was 0.25% (n = 1618). No significant trends were observed for misclassification rates by year, and no significant trend in the standardized optical density over 7 years was observed. Conclusions: Laboratories using the less-sensitive Vironostika HIV-1 assay produced consistent results by use of a common calibrator and quality control materials. C1 [Mei, Joanne V.; Kennedy, Meredith] Ctr Dis Control & Prevent, Div Sci Lab, Atlanta, GA USA. [Linley, Laurie; Hanson, Debra; Ethridge, Steven; Branson, Bernard] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. [Schiffer, Jarad] Ctr Dis Control & Prevent, Div Bacterial Dis, Atlanta, GA USA. RP Mei, JV (reprint author), Newborn Screening Qual Assurance Program, Mail Stop F-19,4770 Buford Hwy NE, Atlanta, GA 30341 USA. EM jmei@cdc.gov NR 42 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD DEC 15 PY 2011 VL 58 IS 5 BP 482 EP 488 DI 10.1097/QAI.0b013e318230dd77 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 846RT UT WOS:000296921600016 PM 21857352 ER PT J AU Liguori, AP Warrington, SD Ginther, JL Pearson, T Bowers, J Glass, MB Mayo, M Wuthiekanun, V Engelthaler, D Peacock, SJ Currie, BJ Wagner, DM Keim, P Tuanyok, A AF Liguori, Andrew P. Warrington, Stephanie D. Ginther, Jennifer L. Pearson, Talima Bowers, Jolene Glass, Mindy B. Mayo, Mark Wuthiekanun, Vanaporn Engelthaler, David Peacock, Sharon J. Currie, Bart J. Wagner, David M. Keim, Paul Tuanyok, Apichai TI Diversity of 16S-23S rDNA Internal Transcribed Spacer (ITS) Reveals Phylogenetic Relationships in Burkholderia pseudomallei and Its Near-Neighbors SO PLOS ONE LA English DT Article ID OPERON COPY NUMBER; PSEUDOMONAS-PSEUDOMALLEI; SEQUENCE-ANALYSIS; MELIOIDOSIS; IDENTIFICATION; SOIL; GENE; MALLEI; REGION; EPIDEMIOLOGY AB Length polymorphisms within the 16S-23S ribosomal DNA internal transcribed spacer (ITS) have been described as stable genetic markers for studying bacterial phylogenetics. In this study, we used these genetic markers to investigate phylogenetic relationships in Burkholderia pseudomallei and its near-relative species. B. pseudomallei is known as one of the most genetically recombined bacterial species. In silico analysis of multiple B. pseudomallei genomes revealed approximately four homologous rRNA operons and ITS length polymorphisms therein. We characterized ITS distribution using PCR and analyzed via a high-throughput capillary electrophoresis in 1,191 B. pseudomallei strains. Three major ITS types were identified, two of which were commonly found in most B. pseudomallei strains from the endemic areas, whereas the third one was significantly correlated with worldwide sporadic strains. Interestingly, mixtures of the two common ITS types were observed within the same strains, and at a greater incidence in Thailand than Australia suggesting that genetic recombination causes the ITS variation within species, with greater recombination frequency in Thailand. In addition, the B. mallei ITS type was common to B. pseudomallei, providing further support that B. mallei is a clone of B. pseudomallei. Other B. pseudomallei near-neighbors possessed unique and monomorphic ITS types. Our data shed light on evolutionary patterns of B. pseudomallei and its near relative species. C1 [Liguori, Andrew P.; Warrington, Stephanie D.; Ginther, Jennifer L.; Pearson, Talima; Wagner, David M.; Keim, Paul; Tuanyok, Apichai] No Arizona Univ, Dept Biol Sci, Ctr Microbial Genet & Genom, Flagstaff, AZ 86011 USA. [Bowers, Jolene; Engelthaler, David] Translat Genom Res Inst N, Div Pathogen Genom, Flagstaff, AZ USA. [Glass, Mindy B.] Ctr Dis Control & Prevent, Bacterial Zoonoses Branch, Div Foodborne Bacterial & Mycot Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA USA. [Mayo, Mark; Currie, Bart J.] Charles Darwin Univ, Menzies Sch Hlth Res, Darwin, NT 0909, Australia. [Wuthiekanun, Vanaporn; Peacock, Sharon J.] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. RP Liguori, AP (reprint author), No Arizona Univ, Dept Biol Sci, Ctr Microbial Genet & Genom, Box 5640, Flagstaff, AZ 86011 USA. EM apichai.tuanyok@nau.edu FU National Institutes of Health (NIH) - National Institute of Allergy and Infectious Diseases (NIAID) [U01 AI075568, U54 AI065359]; US Department of Homeland Security [HSHQDC-10-C-00149] FX This work was supported by National Institutes of Health (NIH) - National Institute of Allergy and Infectious Diseases (NIAID) grant nos. U01 AI075568 (PI: Keim) and U54 AI065359 (PI: Tuanyok), and US Department of Homeland Security contract no. HSHQDC-10-C-00149 (PI: Tuanyok). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 48 TC 13 Z9 13 U1 2 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 14 PY 2011 VL 6 IS 12 AR e29323 DI 10.1371/journal.pone.0029323 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 866GS UT WOS:000298369100172 PM 22195045 ER PT J AU Walcott, BP Kuklina, EV Nahed, BV George, MG Kahle, KT Simard, JM Asaad, WF Coumans, JVCE AF Walcott, Brian P. Kuklina, Elena V. Nahed, Brian V. George, Mary G. Kahle, Kristopher T. Simard, J. Marc Asaad, Wael F. Coumans, Jean-Valery C. E. TI Craniectomy for Malignant Cerebral Infarction: Prevalence and Outcomes in US Hospitals SO PLOS ONE LA English DT Article ID ARTERY INFARCTION; DECOMPRESSIVE CRANIECTOMY; ISCHEMIC-STROKE; HEMISPHERIC INFARCTION; BRAIN EDEMA; HEMICRANIECTOMY; MULTICENTER; RECOVERY; SURGERY; TRIAL AB Object: Randomized trials have demonstrated the efficacy of craniectomy for the treatment of malignant cerebral edema following ischemic stroke. We sought to determine the prevalence and outcomes related to this by using a national database. Methods: Patient discharges with ischemic stroke as the primary diagnosis undergoing craniectomy were queried from the US Nationwide Inpatient Sample from 1999 to 2008. A subpopulation of patients was identified that underwent thrombolysis. Two primary end points were examined: in-hospital mortality and discharge to home/routine care. To facilitate interpretations, adjusted prevalence was calculated from the overall prevalence and two age-specific logistic regression models. The predictive margin was then generated using a multivariate logistic regression model to estimate the probability of in-hospital mortality after adjustment for admission type, admission source, length of stay, total hospital charges, chronic comorbidities, and medical complications. Results: After excluding 71,996 patients with the diagnosis of intracranial hemorrhage and posterior intracranial circulation occlusion, we identified 4,248,955 adult hospitalizations with ischemic stroke as a primary diagnosis. The estimated rates of hospitalizations in craniectomy per 10,000 hospitalizations with ischemic stroke increased from 3.9 in 1999-2000 to 14.46 in 2007-2008 (p for linear trend<0.001). Patients 60+ years of age had in-hospital mortality of 44% while the 18-59 year old group was found to be 24%(p = 0.14). Outcomes were comparable if recombinant tissue plasminogen activator had been administered. Conclusions: Craniectomy is being increasingly performed for malignant cerebral edema following large territory cerebral ischemia. We suspect that the increase in the annual incidence of DC for malignant cerebral edema is directly related to the expanding collection of evidence in randomized trials that the operation is efficacious when performed in the correct patient population. In hospital mortality is high for all patients undergoing this procedure. C1 [Walcott, Brian P.; Nahed, Brian V.; Kahle, Kristopher T.; Coumans, Jean-Valery C. E.] Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 USA. [Walcott, Brian P.; Nahed, Brian V.; Kahle, Kristopher T.; Coumans, Jean-Valery C. E.] Harvard Univ, Sch Med, Boston, MA USA. [Kuklina, Elena V.; George, Mary G.] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Simard, J. Marc] Univ Maryland, Sch Med, Dept Neurosurg, Baltimore, MD 21201 USA. [Asaad, Wael F.] Brown Univ, Sch Med, Dept Neurosurg, Providence, RI 02912 USA. RP Walcott, BP (reprint author), Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 USA. EM walcott.brian@mgh.harvard.edu RI Asaad, Wael/I-8485-2012 OI Asaad, Wael/0000-0003-4406-9096 FU NHLBI NIH HHS [R01 HL082517] NR 38 TC 19 Z9 19 U1 0 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 14 PY 2011 VL 6 IS 12 AR e29193 DI 10.1371/journal.pone.0029193 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 866GS UT WOS:000298369100166 PM 22195021 ER PT J AU Walraven, CJ Gerstein, W Hardison, SE Wormley, F Lockhart, SR Harris, JR Fothergill, A Wickes, B Gober-Wilcox, J Massie, L Ku, TSN Firacative, C Meyer, W Lee, SA AF Walraven, Carla J. Gerstein, Wendy Hardison, Sarah E. Wormley, Floyd Lockhart, Shawn R. Harris, Julie R. Fothergill, Annette Wickes, Brian Gober-Wilcox, Julie Massie, Larry Ku, T. S. Neil Firacative, Carolina Meyer, Wieland Lee, Samuel A. TI Fatal Disseminated Cryptococcus gattii Infection in New Mexico SO PLOS ONE LA English DT Article ID NEOFORMANS VAR GATTII; CLASSICAL MACROPHAGE ACTIVATION; PACIFIC-NORTHWEST; BRITISH-COLUMBIA; UNITED-STATES; VANCOUVER-ISLAND; EMERGING PATHOGEN; OUTBREAK; CANADA; GENOTYPE AB We report a case of fatal disseminated infection with Cryptococcus gattii in a patient from New Mexico. The patient had no history of recent travel to known C. gattii-endemic areas. Multilocus sequence typing revealed that the isolate belonged to the major molecular type VGIII. Virulence studies in a mouse pulmonary model of infection demonstrated that the strain was less virulent than other C. gattii strains. This represents the first documented case of C. gattii likely acquired in New Mexico. C1 [Walraven, Carla J.; Gerstein, Wendy; Gober-Wilcox, Julie; Massie, Larry; Ku, T. S. Neil; Lee, Samuel A.] New Mexico Vet Healthcare Syst, Infect Dis Sect, Albuquerque, NM USA. [Walraven, Carla J.; Gerstein, Wendy; Ku, T. S. Neil; Lee, Samuel A.] Univ New Mexico, Div Infect Dis, Hlth Sci Ctr, Albuquerque, NM 87131 USA. [Hardison, Sarah E.; Wormley, Floyd] Univ Texas San Antonio, Dept Biol, S Texas Ctr Emerging Infect Dis, San Antonio, TX USA. [Lockhart, Shawn R.; Harris, Julie R.] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA USA. [Fothergill, Annette; Wickes, Brian] Univ Texas Hlth Sci Ctr, Dept Microbiol & Immunol, San Antonio, TX USA. [Firacative, Carolina; Meyer, Wieland] Univ Sydney, Westmead Millennium Inst, Mol Mycol Res Lab, Ctr Infect Dis & Microbiol,Sydney Med Sch,Westmea, Sydney, NSW 2006, Australia. RP Walraven, CJ (reprint author), New Mexico Vet Healthcare Syst, Infect Dis Sect, Albuquerque, NM USA. EM SamALee@salud.unm.edu RI Meyer, Wieland/G-1204-2015 OI Meyer, Wieland/0000-0001-9933-8340 FU Biomedical Research Institute of New Mexico from National Institute of Allergy and Infectious Diseases [RO1A107152-03] FX This work was supported in part by the Biomedical Research Institute of New Mexico (S. Lee) and RO1A107152-03 from the National Institute of Allergy and Infectious Diseases (FW). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 47 TC 14 Z9 14 U1 0 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 14 PY 2011 VL 6 IS 12 AR e28625 DI 10.1371/journal.pone.0028625 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 866GS UT WOS:000298369100066 PM 22194869 ER PT J AU Paulozzi, LJ Jones, CM Mack, KA Rudd, RA AF Paulozzi, Leonard J. Jones, Christopher M. Mack, Karin A. Rudd, Rose A. TI Vital Signs: Overdoses of Prescription Opioid Pain Relievers-United States, 1999-2008 (Reprinted from MMWR, vol 60, pg 1487-1492, 2011) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Paulozzi, Leonard J.; Jones, Christopher M.; Mack, Karin A.; Rudd, Rose A.] CDC, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA. RP Paulozzi, LJ (reprint author), CDC, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA. EM lpaulozzi@cdc.gov NR 1 TC 1 Z9 1 U1 2 U2 7 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 14 PY 2011 VL 306 IS 22 BP 2444 EP 2446 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 860YB UT WOS:000297983300009 ER PT J AU Church, D Barton, K Elson, F DeMaria, A Cranston, K Harris, N Liu, S Hu, D Holtzman, D Holmberg, S Tohme, RA AF Church, Daniel Barton, Kerri Elson, Franny DeMaria, Alfred Cranston, Kevin Harris, Norma Liu, Stephen Hu, Dale Holtzman, Deborah Holmberg, Scott Tohme, Rania A. TI Notes From the Field: Risk Factors for Hepatitis C Virus Infections Among Young Adults-Massachusetts, 2010 (Reprinted from MMWR, vol 60, pg 1457-1458, 2011) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Tohme, Rania A.] CDC, EIS, Atlanta, GA 30333 USA. [Church, Daniel; Barton, Kerri; Elson, Franny; DeMaria, Alfred; Cranston, Kevin] Massachusetts Dept Publ Hlth, Boston, MA 02111 USA. [Harris, Norma; Liu, Stephen; Hu, Dale; Holtzman, Deborah; Holmberg, Scott] Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div Viral Hepatitis, Atlanta, GA USA. RP Tohme, RA (reprint author), CDC, EIS, Atlanta, GA 30333 USA. EM rtohme@cdc.gov NR 7 TC 2 Z9 2 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 14 PY 2011 VL 306 IS 22 BP 2448 EP 2448 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 860YB UT WOS:000297983300010 ER PT J AU Harriman, K Thomas, TN Kolasa, M Cullen, K Pabst, L Shefer, A Cox, C Moore, M Link-Gelles, R AF Harriman, Kathleen Thomas, Tracy N. Kolasa, Maureen Cullen, Karen Pabst, Laura Shefer, Abigail Cox, Chad Moore, Matthew Link-Gelles, Ruth TI Invasive Pneumococcal Disease and 13-Valent Pneumococcal Conjugate Vaccine (PCV13) Coverage Among Children Aged <= 59 Months-Selected U.S. Regions, 2010-2011 (Reprinted from MMWR, vol 60, pg 1477-1481, 2011) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint ID UNITED-STATES C1 [Thomas, Tracy N.; Kolasa, Maureen; Cullen, Karen; Pabst, Laura; Shefer, Abigail] CDC, Immunizat Svcs Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Harriman, Kathleen] Calif Dept Hlth, Sacramento, CA USA. [Cox, Chad; Moore, Matthew; Link-Gelles, Ruth] CDC, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Thomas, TN (reprint author), CDC, Immunizat Svcs Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM tct5@cdc.gov NR 10 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 14 PY 2011 VL 306 IS 22 BP 2449 EP 2452 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 860YB UT WOS:000297983300011 ER PT J AU Newton, PN Green, MD Mildenhall, DC Plancon, A Nettey, H Nyadong, L Hostetler, DM Swamidoss, I Harris, GA Powell, K Timmermans, AE Amin, AA Opuni, SK Barbereau, S Faurant, C Soong, RCW Faure, K Thevanayagam, J Fernandes, P Kaur, H Angus, B Stepniewska, K Guerin, PJ Fernandez, FM AF Newton, Paul N. Green, Michael D. Mildenhall, Dallas C. Plancon, Aline Nettey, Henry Nyadong, Leonard Hostetler, Dana M. Swamidoss, Isabel Harris, Glenn A. Powell, Kristen Timmermans, Ans E. Amin, Abdinasir A. Opuni, Stephen K. Barbereau, Serge Faurant, Claude Soong, Ray C. W. Faure, Kevin Thevanayagam, Jonarthan Fernandes, Peter Kaur, Harparkash Angus, Brian Stepniewska, Kasia Guerin, Philippe J. Fernandez, Facundo M. TI Poor quality vital anti-malarials in Africa - an urgent neglected public health priority SO MALARIA JOURNAL LA English DT Article ID ANTIMALARIAL-DRUG QUALITY; FALCIPARUM-MALARIA; MASS-SPECTROMETRY; ARTEMISININ; RESISTANCE AB Background: Plasmodium falciparum malaria remains a major public health problem. A vital component of malaria control rests on the availability of good quality artemisinin-derivative based combination therapy (ACT) at the correct dose. However, there are increasing reports of poor quality anti-malarials in Africa. Methods: Seven collections of artemisinin derivative monotherapies, ACT and halofantrine anti-malarials of suspicious quality were collected in 2002/10 in eleven African countries and in Asia en route to Africa. Packaging, chemical composition (high performance liquid chromatography, direct ionization mass spectrometry, X-ray diffractometry, stable isotope analysis) and botanical investigations were performed. Results: Counterfeit artesunate containing chloroquine, counterfeit dihydroartemisinin (DHA) containing paracetamol (acetaminophen), counterfeit DHA-piperaquine containing sildenafil, counterfeit artemether-lumefantrine containing pyrimethamine, counterfeit halofantrine containing artemisinin, and substandard/counterfeit or degraded artesunate and artesunate+amodiaquine in eight countries are described. Pollen analysis was consistent with manufacture of counterfeits in eastern Asia. These data do not allow estimation of the frequency of poor quality anti-malarials in Africa. Conclusions: Criminals are producing diverse harmful anti-malarial counterfeits with important public health consequences. The presence of artesunate monotherapy, substandard and/or degraded and counterfeit medicines containing sub-therapeutic amounts of unexpected anti-malarials will engender drug resistance. With the threatening spread of artemisinin resistance to Africa, much greater investment is required to ensure the quality of ACTs and removal of artemisinin monotherapies. The International Health Regulations may need to be invoked to counter these serious public health problems. C1 [Newton, Paul N.] Mahosot Hosp, Microbiol Lab, Wellcome Trust Mahosot Hosp Oxford Univ Trop Med, Viangchan, Laos. [Newton, Paul N.; Thevanayagam, Jonarthan; Fernandes, Peter; Angus, Brian; Stepniewska, Kasia; Guerin, Philippe J.] Univ Oxford, Churchill Hosp, Nuffield Dept Med, Ctr Trop Med, Oxford OX3 7LJ, England. [Newton, Paul N.; Kaur, Harparkash] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England. [Newton, Paul N.; Guerin, Philippe J.] Univ Oxford, Churchill Hosp, WorldWide Antimalarial Resistance Network, Oxford OX3 7LJ, England. [Green, Michael D.; Nettey, Henry; Swamidoss, Isabel] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30329 USA. [Mildenhall, Dallas C.; Soong, Ray C. W.; Faure, Kevin] GNS Sci, Lower Hutt 5040, New Zealand. [Plancon, Aline] Int Criminal Police Org INTERPOL, F-69006 Lyon, France. [Nyadong, Leonard; Hostetler, Dana M.; Harris, Glenn A.; Powell, Kristen; Fernandez, Facundo M.] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA. [Timmermans, Ans E.] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. [Amin, Abdinasir A.] Populat Serv Int, Malaria & Child Survival Dept, Nairobi, Kenya. [Opuni, Stephen K.] Food & Drugs Board, Cantonments Accra, Ghana. [Barbereau, Serge] Reseau Medicaments & Dev ReMeD, F-75013 Paris 13, France. [Faurant, Claude] E W Pharmaceut, F-77300 Fontainebleau, France. [Stepniewska, Kasia] Mahidol Univ, Fac Trop Med, Mahidol Oxford Res Unit, Bangkok 10400, Thailand. RP Newton, PN (reprint author), Mahosot Hosp, Microbiol Lab, Wellcome Trust Mahosot Hosp Oxford Univ Trop Med, Viangchan, Laos. EM paul@tropmedres.ac RI Fernandez, Facundo/B-7015-2008; OI Angus, Brian/0000-0003-3598-7784; Guerin, Philippe/0000-0002-6008-2963 FU NSF; USP; Wellcome Trust of Great Britain; Wellcome Trust; ACT Consortium; Bill & Melinda Gates Foundation FX The method development work of FMF was funded by an NSF CAREER grant. LN was partially supported by a USP graduate fellowship. PNN is supported by the Wellcome Trust of Great Britain. Forensic analysis was conducted through the support of the Wellcome Trust and the ACT Consortium, funded by the Bill & Melinda Gates Foundation to the London School of Hygiene and Tropical Medicine. The funding bodies had no role in the design and conduct of the study and had no role in the decision to publish. NR 46 TC 45 Z9 46 U1 0 U2 29 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD DEC 13 PY 2011 VL 10 AR 352 DI 10.1186/1475-2875-10-352 PG 22 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 893JY UT WOS:000300353400001 PM 22152094 ER PT J AU Graves, PM Ngondi, JM Hwang, J Getachew, A Gebre, T Mosher, AW Patterson, AE Shargie, EB Tadesse, Z Wolkon, A Reithinger, R Emerson, PM Richards, FO AF Graves, Patricia M. Ngondi, Jeremiah M. Hwang, Jimee Getachew, Asefaw Gebre, Teshome Mosher, Aryc W. Patterson, Amy E. Shargie, Estifanos B. Tadesse, Zerihun Wolkon, Adam Reithinger, Richard Emerson, Paul M. Richards, Frank O., Jr. TI Factors associated with mosquito net use by individuals in households owning nets in Ethiopia SO MALARIA JOURNAL LA English DT Article DE Malaria; Mosquito net; Ethiopia; GLLAMM; Survey; Net use ID INSECTICIDE-TREATED NETS; RANDOMIZED CONTROLLED-TRIAL; BED NETS; MALARIA PREVENTION; PREGNANT-WOMEN; WESTERN KENYA; RISK-FACTORS; DETERMINANTS; COVERAGE; CHILDREN AB Background: Ownership of insecticidal mosquito nets has dramatically increased in Ethiopia since 2006, but the proportion of persons with access to such nets who use them has declined. It is important to understand individual level net use factors in the context of the home to modify programmes so as to maximize net use. Methods: Generalized linear latent and mixed models (GLLAMM) were used to investigate net use using individual level data from people living in net-owning households from two surveys in Ethiopia: baseline 2006 included 12,678 individuals from 2,468 households and a sub-sample of the Malaria Indicator Survey (MIS) in 2007 included 14,663 individuals from 3,353 households. Individual factors (age, sex, pregnancy); net factors (condition, age, net density); household factors (number of rooms [2006] or sleeping spaces [2007], IRS, women's knowledge and school attendance [2007 only], wealth, altitude); and cluster level factors (rural or urban) were investigated in univariate and multi-variable models for each survey. Results: In 2006, increased net use was associated with: age 25-49 years (adjusted (a) OR = 1.4, 95% confidence interval (CI) 1.2-1.7) compared to children U5; female gender (aOR = 1.4; 95% CI 1.2-1.5); fewer nets with holes (Ptrend = 0.002); and increasing net density (Ptrend < 0.001). Reduced net use was associated with: age 5-24 years (aOR = 0.2; 95% CI 0.2-0.3). In 2007, increased net use was associated with: female gender (aOR = 1.3; 95% CI 1.1-1.6); fewer nets with holes (aOR ([all nets in HH good]) = 1.6; 95% CI 1.2-2.1); increasing net density (Ptrend < 0.001); increased women's malaria knowledge (Ptrend < 0.001); and urban clusters (aOR = 2.5; 95% CI 1.5-4.1). Reduced net use was associated with: age 524 years (aOR = 0.3; 95% CI 0.2-0.4); number of sleeping spaces (aOR ([per additional space]) = 0.6, 95% CI 0.5-0.7); more old nets (aOR ([all nets in HH older than 12 months]) = 0.5; 95% CI 0.3-0.7); and increasing household altitude (Ptrend < 0.001). Conclusion: In both surveys, net use was more likely by women, if nets had fewer holes and were at higher net per person density within households. School-age children and young adults were much less likely to use a net. Increasing availability of nets within households (i.e. increasing net density), and improving net condition while focusing on education and promotion of net use, especially in school-age children and young adults in rural areas, are crucial areas for intervention to ensure maximum net use and consequent reduction of malaria transmission. C1 [Graves, Patricia M.; Ngondi, Jeremiah M.; Mosher, Aryc W.; Patterson, Amy E.; Emerson, Paul M.; Richards, Frank O., Jr.] Emory Univ, Carter Ctr, Atlanta, GA 30322 USA. [Ngondi, Jeremiah M.] Univ Cambridge, Cambridge, England. [Hwang, Jimee; Wolkon, Adam] Ctr Dis Control & Prevent, Atlanta, GA USA. [Hwang, Jimee] Univ Calif San Francisco, Global Hlth Grp, San Francisco, CA 94143 USA. [Getachew, Asefaw] MACEPA, Addis Ababa, Ethiopia. [Gebre, Teshome; Shargie, Estifanos B.; Tadesse, Zerihun] Carter Ctr, Addis Ababa, Ethiopia. [Shargie, Estifanos B.] Global Fund Fight AIDS TB & Malaria, Strateg Informat Team, CH-1214 Geneva, Vernier, Switzerland. [Tadesse, Zerihun] Federal Minist Hlth, Addis Ababa, Ethiopia. [Reithinger, Richard] US Agcy Int Dev, Addis Ababa, Ethiopia. [Graves, Patricia M.] Sch Publ Hlth Trop Med & Rehabil Sci, Fac Med Hlth & Mol Sci, Cairns, Qld 4870, Australia. [Gebre, Teshome] Task Force Global Hlth, Int Trachoma Initiat, Addis Ababa, Ethiopia. RP Graves, PM (reprint author), Emory Univ, Carter Ctr, Atlanta, GA 30322 USA. EM pgraves.work@gmail.com RI Graves, Patricia/J-8691-2014 OI Graves, Patricia/0000-0002-5215-3901 FU The Carter Center; Amhara; Oromia; SNNP Regional Health Bureaus; Federal Ministry of Health of Ethiopia; Malaria Control and Evaluation Partnership for Africa (MACEPA); World Health Organization (WHO); United Nations Children's Fund (UNICEF); President's Malaria Initiative [US Agency for International Development (USAID)/US Centers for Disease Control and Prevention (CDC)]; Ethiopia Central Statistical Agency; Center for National Health Development in Ethiopia; Malaria Consortium; President's Malaria Initiative via the Office of Health, Infectious Diseases, and Nutrition, Bureau for Global Health; US Agency for International Development; CDC FX The baseline survey was financially and technically supported by The Carter Center and carried out in collaboration with the Amhara, Oromia and SNNP Regional Health Bureaus. The follow-up Malaria Indicator Survey 2007 was the result of joint support and efforts by multiple partners, including the Federal Ministry of Health of Ethiopia, The Carter Center, Malaria Control and Evaluation Partnership for Africa (MACEPA, a program at PATH), World Health Organization (WHO), United Nations Children's Fund (UNICEF), President's Malaria Initiative [US Agency for International Development (USAID)/US Centers for Disease Control and Prevention (CDC)], the Ethiopia Central Statistical Agency, Center for National Health Development in Ethiopia, and Malaria Consortium.; This research was made possible through support provided by the President's Malaria Initiative via the Office of Health, Infectious Diseases, and Nutrition, Bureau for Global Health, US Agency for International Development, under the terms of an inter-agency agreement with CDC. The opinions expressed herein are those of the author(s) and do not necessarily reflect the views of the US Centers for Disease Control and Prevention, the US Agency for International Development, or other employing organizations or sources of funding. NR 43 TC 26 Z9 26 U1 0 U2 11 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD DEC 13 PY 2011 VL 10 AR 354 DI 10.1186/1475-2875-10-354 PG 12 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 875TR UT WOS:000299058500001 PM 22165821 ER PT J AU Stormo, AR Hawkins, NA Cooper, CP Saraiya, M AF Stormo, Analia R. Hawkins, Nikki A. Cooper, Crystale Purvis Saraiya, Mona TI The Pelvic Examination as a Screening Tool: Practices of US Physicians SO ARCHIVES OF INTERNAL MEDICINE LA English DT Letter ID CANCER C1 [Stormo, Analia R.; Hawkins, Nikki A.; Saraiya, Mona] CDC, Div Canc Prevent & Control, Atlanta, GA 30333 USA. [Cooper, Crystale Purvis] Soltera Ctr Canc Prevent & Control Res, Tucson, AZ USA. RP Saraiya, M (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, 4770 Buford Hwy NE,Mail Stop K-55, Atlanta, GA 30341 USA. EM msaraiya@cdc.gov NR 8 TC 21 Z9 21 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD DEC 12 PY 2011 VL 171 IS 22 BP 2053 EP 2054 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 860VD UT WOS:000297975100016 PM 22158576 ER PT J AU Yang, QH Liu, TB Kuklina, EV Flanders, WD Hong, YL Khoury, MJ Hu, FB AF Yang, Quanhe Liu, Tiebin Kuklina, Elena V. Flanders, W. Dana Hong, Yuling Khoury, Muin J. Hu, Frank B. TI Method of Estimating Sodium Intake and Its Possible Influence on NHANES III Outcome Reply SO ARCHIVES OF INTERNAL MEDICINE LA English DT Letter ID CARDIOVASCULAR-DISEASE; POTASSIUM INTAKE; FOLLOW-UP; TRIALS; METAANALYSIS; PREVENTION; MORTALITY; SALT C1 [Yang, Quanhe] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA 30341 USA. [Flanders, W. Dana] Emory Univ, Dept Epidemiol, Atlanta, GA 30322 USA. [Hu, Frank B.] Harvard Univ, Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA 02115 USA. RP Yang, QH (reprint author), Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, 4770 Buford Hwy,NE Mail Stop F-72, Atlanta, GA 30341 USA. EM qay0@cdc.gov NR 6 TC 0 Z9 0 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD DEC 12 PY 2011 VL 171 IS 22 BP 2064 EP 2064 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 860VD UT WOS:000297975100024 ER PT J AU Lavelle, TA Meltzer, MI Gebremariam, A Lamarand, K Fiore, AE Prosser, LA AF Lavelle, Tara A. Meltzer, Martin I. Gebremariam, Achamyeleh Lamarand, Kara Fiore, Anthony E. Prosser, Lisa A. TI Community-Based Values for 2009 Pandemic Influenza A H1N1 Illnesses and Vaccination-Related Adverse Events SO PLOS ONE LA English DT Article ID HEALTH STATES; PREFERENCE; SCORES; PEOPLE AB Objective: To evaluate community-based values for avoiding pandemic influenza (A) H1N1 (pH1N1) illness and vaccination-related adverse events in adults and children. Methods: Adult community members were randomly selected from a nationally representative research panel to complete an internet survey (response rate = 65%; n = 718). Respondents answered a series of time trade-off questions to value four hypothetical health state scenarios for varying ages (1, 8, 35, or 70 years): uncomplicated pH1N1 illness, pH1N1 illness-related hospitalization, severe allergic reaction to the pH1N1 vaccine, and Guillain-Barre syndrome. We calculated descriptive statistics for time trade-off amounts and derived quality adjusted life year losses for these events. Multivariate regression analyses evaluated the effect of scenario age, as well as respondent socio-demographic and health characteristics on time trade-off amounts. Results: Respondents were willing to trade more time to avoid the more severe outcomes, hospitalization and Guillain-Barre syndrome. In our adjusted and unadjusted analyses, age of the patient in the scenario was significantly associated with time trade-off amounts (p-value<0.05), with respondents willing to trade more time to prevent outcomes in children versus adults. Persons who had received the pH1N1 vaccination were willing to trade significantly more time to avoid hospitalization, severe allergic reaction, and Guillain-Barre syndrome, controlling for other variables in adjusted analyses.(p-value<0.05) Conclusions: Community members placed the highest value on preventing outcomes in children, compared with adults, and the time trade-off values reported were consistent with the severity of the outcomes presented. Considering these public values along with other decision-making factors may help policy makers improve the allocation of pandemic vaccine resources. C1 [Lavelle, Tara A.] Harvard Univ, PhD Program Hlth Policy, Cambridge, MA 02138 USA. [Lavelle, Tara A.] Harvard Univ, Sch Publ Hlth, Ctr Hlth Decis Sci, Boston, MA 02115 USA. [Meltzer, Martin I.; Fiore, Anthony E.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Gebremariam, Achamyeleh; Lamarand, Kara; Prosser, Lisa A.] Univ Michigan Hlth Syst, Child Hlth Evaluat & Res Unit, Div Gen Pediat, Ann Arbor, MI USA. RP Lavelle, TA (reprint author), Harvard Univ, PhD Program Hlth Policy, Cambridge, MA 02138 USA. EM tlavelle@fas.harvard.edu FU Centers for Disease Control and Prevention FX This study was funded by the Centers for Disease Control and Prevention. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 25 TC 4 Z9 4 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 9 PY 2011 VL 6 IS 12 AR e27777 DI 10.1371/journal.pone.0027777 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 870JO UT WOS:000298665600002 PM 22205927 ER PT J AU Marston, CK Allen, CA Beaudry, J Price, EP Wolken, SR Pearson, T Keim, P Hoffmaster, AR AF Marston, Chung K. Allen, Christina A. Beaudry, Jodi Price, Erin P. Wolken, Spenser R. Pearson, Talima Keim, Paul Hoffmaster, Alex R. TI Molecular Epidemiology of Anthrax Cases Associated with Recreational Use of Animal Hides and Yarn in the United States SO PLOS ONE LA English DT Article ID BACILLUS-ANTHRACIS AB To determine potential links between the clinical isolate to animal products and their geographic origin, we genotyped (MLVA-8, MVLA-15, and canSNP analysis) 80 environmental and 12 clinical isolates and 2 clinical specimens from five cases of anthrax (California in 1976 [n = 1], New York in 2006 [n = 1], Connecticut in 2007 [n = 2], and New Hampshire in 2009[n = 1]) resulting from recreational handling of animal products. For the California case, four clinical isolates were identified as MLVA-8 genotype (GT) 76 and in the canSNP A.Br.Vollum lineage, which is consistent with the Pakistani origin of the yarn. Twenty eight of the California isolates were in the A.Br.Vollum canSNP lineage and one isolate was in the A.Br.003/004 canSNP sub-group. All 52 isolates and both clinical specimens related to the New York and Connecticut cases were MLVA-8 GT 1. The animal products associated with the NY and CT cases were believed to originate from West Africa, but no isolates from this region are available to be genotyped for comparison. All isolates associated with the New Hampshire case were identical and had a new genotype (GT 149). Isolates from the NY, CT and NH cases diverge from the established canSNP phylogeny near the base of the A.Br.011/009. This report illustrates the power of the current genotyping methods and the dramatically different epidemiological conditions that can lead to infections (i.e., contamination by a single genotype versus widespread contamination of numerous genotypes). These cases illustrate the need to acquire and genotype global isolates so that accurate assignments can be made about isolate origins. C1 [Marston, Chung K.; Hoffmaster, Alex R.] Ctr Dis Control & Prevent, Bacterial Special Pathogens Branch, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Allen, Christina A.; Beaudry, Jodi; Price, Erin P.; Wolken, Spenser R.; Pearson, Talima; Keim, Paul] No Arizona Univ, Dept Biol Sci, Flagstaff, AZ 86011 USA. RP Marston, CK (reprint author), Ctr Dis Control & Prevent, Bacterial Special Pathogens Branch, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. EM cdk5@cdc.gov RI Price, Erin/N-2336-2013 OI Price, Erin/0000-0002-1079-4882 FU U.S. Department of Homeland Security S&T CB Division Bioforensics FX Portions of this work were supported by the U.S. Department of Homeland Security S&T CB Division Bioforensics R&D Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. No additional external funding was received for this report. NR 13 TC 15 Z9 15 U1 1 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 9 PY 2011 VL 6 IS 12 AR e28274 DI 10.1371/journal.pone.0028274 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 866FK UT WOS:000298365700026 PM 22174783 ER PT J AU Zhao, Z Murphy, TV Jacques-Carroll, L AF Zhao, Zhen Murphy, Trudy V. Jacques-Carroll, Lisa TI Progress in newborn hepatitis B vaccination by birth year cohorts-1998-2007, USA SO VACCINE LA English DT Article DE Hepatitis B vaccine; Birth dose; Universal vaccination; Coverage; Thimerosal; ACIP recommendations ID COVERAGE; RECOMMENDATIONS; CHILDREN; THIMEROSAL; IMPACT; POLICIES; VIRUS AB Background: In 1999, the American Academy of Pediatrics (AAP) and the U.S. Public Health Service (USPHS) issued a joint statement on thimerosal in vaccines, which advised clinicians to temporarily postpone the first dose of hepatitis B vaccine for infants born to hepatitis B surface antigen (HBsAg)-negative women. In 2005, the Advisory Committee on Immunization Practices (ACIP) updated the strategy to improve prevention of perinatal and early childhood hepatitis B virus (HBV) transmission. Objectives: To evaluate the progress in hepatitis B birth dose vaccination coverage in birth year cohort from 1998 to 2007 and assess the impact of changes in ACIP recommendations on the birth dose coverage. Methods: Birth year cohort study of hepatitis B birth dose vaccination status of 200,865 children aged 19-35 months in the United States and by selected socio-demographic factors; percentage increases of hepatitis B birth dose vaccination coverage between two consecutive birth year cohorts from 1998 to 2007. Results: From 1998 to 1999, hepatitis B birth dose vaccination coverage declined overall in the United States and among selected socio-demographic groups (P < 0.001). Conversely, from 1999 to 2007 hepatitis B birth dose vaccination coverage increased significantly by birth year cohort (P < 0.001), from approximately 30% in the 1999 birth year cohort to approximately 60% in the 2007 birth year cohort. The first significant increase in hepatitis B birth dose vaccination coverage occurred from 2000 to 2001 birth year cohort. Coverage increases ranged from 8.4% to 11.9% (P < 0.001) in the U.S. and across all socio-demographic strata. The second largest increase in hepatitis B birth dose vaccination coverage occurred from 2005 to 2006 birth year cohort in the U.S. and among almost all socio-demographic strata, ranging from 5.6% to 8.7% (P < 0.001). Forty-one of the 50 states and the District of Columbia (80%) in the U.S. had increases in hepatitis B birth dose vaccination coverage from 2005 to 2006 birth year cohort. Conclusions: The United States has made substantial progress in increasing hepatitis B birth dose vaccination and recovered from coverage declines associated with temporary postponement of the birth dose in 1999. The hepatitis B birth dose coverage in the U.S. remains substantially below the Healthy People 2020 target of 85%. Published by Elsevier Ltd. C1 [Zhao, Zhen; Jacques-Carroll, Lisa] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Murphy, Trudy V.] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS, STD & TB Prevent, Atlanta, GA 30333 USA. RP Zhao, Z (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,Mail Stop A19, Atlanta, GA 30333 USA. EM zaz0@cdc.gov NR 28 TC 6 Z9 6 U1 1 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD DEC 9 PY 2011 VL 30 IS 1 BP 14 EP 20 DI 10.1016/j.vaccine.2011.10.076 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 868NA UT WOS:000298528800004 PM 22063390 ER PT J AU Sterling, TR Villarino, ME Borisov, AS Shang, N Gordin, F Bliven-Sizemore, E Hackman, J Hamilton, CD Menzies, D Kerrigan, A Weis, SE Weiner, M Wing, D Conde, MB Bozeman, L Horsburgh, CR Chaisson, RE AF Sterling, Timothy R. Villarino, M. Elsa Borisov, Andrey S. Shang, Nong Gordin, Fred Bliven-Sizemore, Erin Hackman, Judith Hamilton, Carol Dukes Menzies, Dick Kerrigan, Amy Weis, Stephen E. Weiner, Marc Wing, Diane Conde, Marcus B. Bozeman, Lorna Horsburgh, C. Robert, Jr. Chaisson, Richard E. CA TB Trials Consortium PREVENT TB TI Three Months of Rifapentine and Isoniazid for Latent Tuberculosis Infection SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID PREVENTIVE THERAPY; UNITED-STATES; RANDOMIZED-TRIAL; CLINICAL-TRIAL; HIV-INFECTION; RIFAMPIN; PYRAZINAMIDE; PHARMACOKINETICS; IMMUNOCOMPETENT; RIFABUTIN AB BACKGROUND Treatment of latent Mycobacterium tuberculosis infection is an essential component of tuberculosis control and elimination. The current standard regimen of isoniazid for 9 months is efficacious but is limited by toxicity and low rates of treatment completion. METHODS We conducted an open-label, randomized noninferiority trial comparing 3 months of directly observed once-weekly therapy with rifapentine (900 mg) plus isoniazid (900 mg) (combination-therapy group) with 9 months of self-administered daily isoniazid (300 mg) (isoniazid-only group) in subjects at high risk for tuberculosis. Subjects were enrolled from the United States, Canada, Brazil, and Spain and followed for 33 months. The primary end point was confirmed tuberculosis, and the noninferiority margin was 0.75%. RESULTS In the modified intention-to-treat analysis, tuberculosis developed in 7 of 3986 subjects in the combination-therapy group (cumulative rate, 0.19%) and in 15 of 3745 subjects in the isoniazid-only group (cumulative rate, 0.43%), for a difference of 0.24 percentage points. Rates of treatment completion were 82.1% in the combination-therapy group and 69.0% in the isoniazid-only group (P<0.001). Rates of permanent drug discontinuation owing to an adverse event were 4.9% in the combination-therapy group and 3.7% in the isoniazid-only group (P = 0.009). Rates of investigator-assessed drug-related hepatotoxicity were 0.4% and 2.7%, respectively (P<0.001). CONCLUSIONS The use of rifapentine plus isoniazid for 3 months was as effective as 9 months of isoniazid alone in preventing tuberculosis and had a higher treatment-completion rate. Long-term safety monitoring will be important. (Funded by the Centers for Disease Control and Prevention; PREVENT TB ClinicalTrials.gov number, NCT00023452.) C1 [Villarino, M. Elsa; Borisov, Andrey S.; Shang, Nong; Bliven-Sizemore, Erin; Bozeman, Lorna] Ctr Dis Control & Prevent, Atlanta, GA USA. [Gordin, Fred] George Washington Univ, Washington, DC USA. [Gordin, Fred] Washington DC Vet Affairs Med Ctr, Washington, DC USA. [Hackman, Judith; Chaisson, Richard E.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Hamilton, Carol Dukes] Family Hlth Int, Durham, NC USA. [Hamilton, Carol Dukes] Duke Univ, Durham, NC USA. [Menzies, Dick] McGill Univ, Montreal Chest Inst, Montreal, PQ, Canada. [Weis, Stephen E.] Univ N Texas Hlth Sci Ctr Ft Worth, Ft Worth, TX USA. [Weiner, Marc] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Weiner, Marc] S Texas Vet Hlth Care Syst, San Antonio, TX USA. [Wing, Diane] S Texas Consortium, Harlingen, TX USA. [Conde, Marcus B.] Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil. [Horsburgh, C. Robert, Jr.] Boston Univ, Sch Med, Boston, MA 02118 USA. [Sterling, Timothy R.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA. RP Sterling, TR (reprint author), A2209 Med Ctr N, 1161 21st Ave S, Nashville, TN 37232 USA. EM timothy.sterling@vanderbilt.edu RI Conde, Marcus/A-2501-2013 FU CDC; Bristol-Myers Squibb; Pfizer; Sanofi-Aventis; Otsuka America Pharmaceutical FX Supported by the CDC.; Dr. Sterling reports receiving research grant funding from Bristol-Myers Squibb and Pfizer for HIV observational studies; Dr. Hamilton, being employed by Family Health International; Dr. Weiner, receiving research grant funding from Sanofi-Aventis; and Dr. Horsburgh, receiving payments from Otsuka America Pharmaceutical for scientific reviews of study protocols. No other potential conflict of interest relevant to this article was reported. NR 39 TC 239 Z9 249 U1 6 U2 27 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD DEC 8 PY 2011 VL 365 IS 23 BP 2155 EP 2166 PG 12 WC Medicine, General & Internal SC General & Internal Medicine GA 857PQ UT WOS:000297731400001 PM 22150035 ER PT J AU Crider, KS Quinlivan, EP Berry, RJ Hao, L Li, Z Maneval, D Yang, TP Rasmussen, SA Yang, QH Zhu, JH Hu, DJ Bailey, LB AF Crider, Krista S. Quinlivan, Eoin P. Berry, Robert J. Hao, Ling Li, Zhu Maneval, David Yang, Thomas P. Rasmussen, Sonja A. Yang, Quanhe Zhu, Jiang-Hui Hu, Dale J. Bailey, Lynn B. TI Genomic DNA Methylation Changes in Response to Folic Acid Supplementation in a Population-Based Intervention Study among Women of Reproductive Age SO PLOS ONE LA English DT Article ID MODERATE FOLATE-DEPLETION; NEURAL-TUBE DEFECTS; DOUBLE-BLIND TRIAL; METHYLENETETRAHYDROFOLATE REDUCTASE; MEGALOBLASTIC-ANEMIA; VENOUS THROMBOSIS; POLYMORPHISM; HOMOCYSTEINE; DEFICIENCY; MTHFR AB Folate is a source of one-carbons necessary for DNA methylation, a critical epigenetic modification necessary for genomic structure and function. The use of supplemental folic acid is widespread however; the potential influence on DNA methylation is unclear. We measured global DNA methylation using DNA extracted from samples from a population-based, double-blind randomized trial of folic acid supplementation (100, 400, 4000 mu g per day) taken for 6 months; including a 3 month post-supplementation sample. We observed no changes in global DNA methylation in response to up to 4,000 mu g/day for 6 months supplementation in DNA extracted from uncoagulated blood (approximates circulating blood). However, when DNA methylation was determined in coagulated samples from the same individuals at the same time, significant time, dose, and MTHFR genotype-dependent changes were observed. The baseline level of DNA methylation was the same for uncoagulated and coagulated samples; marked differences between sample types were observed only after intervention. In DNA from coagulated blood, DNA methylation decreased (-14%; P < 0.001) after 1 month of supplementation and 3 months after supplement withdrawal, methylation decreased an additional 23% (P < 0.001) with significant variation among individuals (max+17%; min-94%). Decreases in methylation of >= 25% (vs. < 25%) after discontinuation of supplementation were strongly associated with genotype: MTHFR CC vs. TT (adjusted odds ratio [aOR] 12.9, 95%CI 6.4, 26.0). The unexpected difference in DNA methylation between DNA extracted from coagulated and uncoagulated samples in response to folic acid supplementation is an important finding for evaluating use of folic acid and investigating the potential effects of folic acid supplementation on coagulation. C1 [Crider, Krista S.; Berry, Robert J.; Hao, Ling; Rasmussen, Sonja A.; Yang, Quanhe; Hu, Dale J.] Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Quinlivan, Eoin P.] Univ Florida, Gen Clin Res Ctr, Biomed Mass Spectrometry Lab, Gainesville, FL USA. [Hao, Ling; Li, Zhu] Peking Univ, Hlth Sci Ctr, Beijing 100871, Peoples R China. [Maneval, David; Zhu, Jiang-Hui; Bailey, Lynn B.] Univ Florida, Food Sci & Human Nutr Dept, Gainesville, FL USA. [Yang, Thomas P.] Univ Florida, Coll Med, Dept Biochem & Mol Biol, Ctr Epigenet,Div Pediat Genet, Gainesville, FL 32610 USA. RP Crider, KS (reprint author), Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. EM kcrider@cdc.gov OI Berry, Robert/0000-0002-7162-5046 FU BDB/DBDDD/NCBDDD/CDC (Birth Defects Branch, Division of Birth Defects and Developmental Disabilities, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention) FX Funding for this study was provided by a cooperative agreement from BDB/DBDDD/NCBDDD/CDC (Birth Defects Branch, Division of Birth Defects and Developmental Disabilities, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention). As a part of a public health scientific agency, CDC employees were directly involved in the study design, analysis, decision to publish and preparation of the manuscript. NR 38 TC 18 Z9 18 U1 0 U2 9 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 7 PY 2011 VL 6 IS 12 AR e28144 DI 10.1371/journal.pone.0028144 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 863KK UT WOS:000298161900016 PM 22163281 ER PT J AU Gillece, JD Schupp, JM Balajee, SA Harris, J Pearson, T Yan, YP Keim, P DeBess, E Marsden-Haug, N Wohrle, R Engelthaler, DM Lockhart, SR AF Gillece, John D. Schupp, James M. Balajee, S. Arunmozhi Harris, Julie Pearson, Talima Yan, Yongpan Keim, Paul DeBess, Emilio Marsden-Haug, Nicola Wohrle, Ron Engelthaler, David M. Lockhart, Shawn R. TI Whole Genome Sequence Analysis of Cryptococcus gattii from the Pacific Northwest Reveals Unexpected Diversity SO PLOS ONE LA English DT Article ID NEOFORMANS VAR. GATTII; BRITISH-COLUMBIA; VANCOUVER-ISLAND; OUTBREAK; CANADA; LINEAGES; SOFTWARE; GENOTYPE; STRAINS; USA AB A recent emergence of Cryptococcus gattii in the Pacific Northwest involves strains that fall into three primarily clonal molecular subtypes: VGIIa, VGIIb and VGIIc. Multilocus sequence typing (MLST) and variable number tandem repeat analysis appear to identify little diversity within these molecular subtypes. Given the apparent expansion of these subtypes into new geographic areas and their ability to cause disease in immunocompetent individuals, differentiation of isolates belonging to these subtypes could be very important from a public health perspective. We used whole genome sequence typing (WGST) to perform fine-scale phylogenetic analysis on 20 C. gattii isolates, 18 of which are from the VGII molecular type largely responsible for the Pacific Northwest emergence. Analysis both including and excluding (289,586 SNPs and 56,845 SNPs, respectively) molecular types VGI and VGIII isolates resulted in phylogenetic reconstructions consistent, for the most part, with MLST analysis but with far greater resolution among isolates. The WGST analysis presented here resulted in identification of over 100 SNPs among eight VGIIc isolates as well as unique genotypes for each of the VGIIa, VGIIb and VGIIc isolates. Similar levels of genetic diversity were found within each of the molecular subtype isolates, despite the fact that the VGIIb clade is thought to have emerged much earlier. The analysis presented here is the first multi-genome WGST study to focus on the C. gattii molecular subtypes involved in the Pacific Northwest emergence and describes the tools that will further our understanding of this emerging pathogen. C1 [Gillece, John D.; Schupp, James M.; Engelthaler, David M.] Translat Genom Res Inst, Pathogen Genom Div, Flagstaff, AZ USA. [Balajee, S. Arunmozhi; Harris, Julie; Lockhart, Shawn R.] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA USA. [Pearson, Talima; Keim, Paul] No Arizona Univ, Ctr Microbial Genet & Gen, Flagstaff, AZ 86011 USA. [Yan, Yongpan] Van Andel Inst, Ctr Genet Epidemiol & Prevent, Grand Rapids, MI USA. [DeBess, Emilio] Oregon State Dept Human Serv, Portland, OR USA. [Marsden-Haug, Nicola; Wohrle, Ron] Washington State Dept Hlth, Shoreline, WA USA. [Wohrle, Ron] Washington Dept Hlth, Tumwater, WA USA. RP Gillece, JD (reprint author), Translat Genom Res Inst, Pathogen Genom Div, Flagstaff, AZ USA. EM jschupp@tgen.org FU Translational Genomics Research Institute; Centers for Disease Control and Prevention FX All work was funded by the Translational Genomics Research Institute and the Centers for Disease Control and Prevention. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 27 TC 35 Z9 36 U1 1 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 7 PY 2011 VL 6 IS 12 AR e28550 DI 10.1371/journal.pone.0028550 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 863KK UT WOS:000298161900049 PM 22163313 ER PT J AU Mitchell, T Armstrong, GL Hu, DJ Wasley, A Painter, JA AF Mitchell, Tarissa Armstrong, Gregory L. Hu, Dale J. Wasley, Annemarie Painter, John A. TI The Increasing Burden of Imported Chronic Hepatitis B - United States, 1974-2008 SO PLOS ONE LA English DT Article ID VIRUS-INFECTION; DISEASE BURDEN; CARRIER STATE; VACCINATION; AGE AB Background: Without intervention, up to 25% of individuals chronically infected with hepatitis B virus (HBV) die of late complications, including cirrhosis and liver cancer. The United States, which in 1991 implemented a strategy to eliminate HBV transmission through universal immunization, is a country of low prevalence. Approximately 3,000-5,000 U. S.-acquired cases of chronic hepatitis B have occurred annually since 2001. Many more chronically infected persons migrate to the United States yearly from countries of higher prevalence. Although early identification of chronic HBV infection can reduce the likelihood of transmission and late complications, immigrants are not routinely screened for HBV infection during or after immigration. Methods: To estimate the number of imported cases of chronic hepatitis B, we multiplied country-specific prevalence estimates by the yearly number of immigrants from each country during 1974-2008. Results: During 1974-2008, 27.9 million immigrants entered the U. S. Sixty-three percent were born in countries of intermediate or high chronic hepatitis B prevalence (range 2%-31%). On average, an estimated 53,800 chronic hepatitis B cases were imported to the U. S. yearly from 2004 through 2008. The Philippines, China, and Vietnam contributed the most imported cases (13.4%, 12.5%, and 11.0%, respectively). Imported cases increased from an estimated low of 105,750 during the period 1974-1977 to a high of 268,800 in 2004-2008. Conclusions: Imported chronic hepatitis B cases account for approximately 95% of new U. S. cases. Earlier case identification and management of infected immigrants would strengthen the U. S. strategy to eliminate HBV transmission, and could delay disease progression and prevent some deaths among new Americans. C1 [Mitchell, Tarissa; Painter, John A.] Ctr Dis Control & Prevent, Immigrant Refugee & Migrant Hlth Branch, Atlanta, GA 30333 USA. [Armstrong, Gregory L.] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA. [Hu, Dale J.] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA USA. [Wasley, Annemarie] Ctr Dis Control & Prevent, Global Immunizat Div, Atlanta, GA USA. [Mitchell, Tarissa] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA. RP Mitchell, T (reprint author), Ctr Dis Control & Prevent, Immigrant Refugee & Migrant Hlth Branch, Atlanta, GA 30333 USA. EM TMitchell1@cdc.gov NR 24 TC 28 Z9 28 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 7 PY 2011 VL 6 IS 12 AR e27717 DI 10.1371/journal.pone.0027717 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 863KK UT WOS:000298161900006 PM 22163270 ER PT J AU Gilchrist, J Thomas, KE Xu, LK McGuire, LC Coronado, V AF Gilchrist, Julie Thomas, Karen E. Xu, Likang McGuire, Lisa C. Coronado, Victor TI Nonfatal Traumatic Brain Injuries Related to Sports and Recreation Activities Among Persons Aged <= 19 Years-United States, 2001-2009 (Reprinted from MMWR, vol 60, pg 1337-1342, 2011) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Gilchrist, Julie] CDC, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA. [Thomas, Karen E.; Xu, Likang; McGuire, Lisa C.; Coronado, Victor] CDC, Div Injury Response, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA. RP Gilchrist, J (reprint author), CDC, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA. EM jgilchrist1@cdc.gov NR 1 TC 1 Z9 1 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 7 PY 2011 VL 306 IS 21 BP 2318 EP 2320 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 856YH UT WOS:000297680300008 ER PT J AU Cosgrove, S Cronquist, A Wright, G Ghosh, T Vogt, R Teitell, P Gelfius, A Spires, C Duvernoy, T Merriweather, S Freeman, M Griffin, PM Jackson, KA Joseph, LA Mahon, BE Neil, K Silk, BJ Tarr, C Tauxe, R Trees, E Ibraheem, M Imanishi, M Jain, N McCollum, J O'Connor, KA AF Cosgrove, Shaun Cronquist, Alicia Wright, Gail Ghosh, Tista Vogt, Richard Teitell, Paul Gelfius, Allen Spires, Charlotte Duvernoy, Tracy Merriweather, Sheila Freeman, Molly Griffin, Patricia M. Jackson, Kelly A. Joseph, Lavin A. Mahon, Barbara E. Neil, Karen Silk, Benjamin J. Tarr, Cheryl Tauxe, Robert Trees, Eija Ibraheem, Mam Imanishi, Maho Jain, Neena McCollum, Jeffrey O'Connor, Katherine A. TI Multistate Outbreak of Listeriosis Associated With Jensen Farms Cantaloupe-United States, August-September 2011 (Reprinted from MMWR, vol 60, pg 1357-1358, 2011) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Ibraheem, Mam; Imanishi, Maho; Jain, Neena; McCollum, Jeffrey; O'Connor, Katherine A.] CDC, Atlanta, GA 30333 USA. EM gqv8@cdc.gov NR 1 TC 0 Z9 0 U1 3 U2 13 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 7 PY 2011 VL 306 IS 21 BP 2321 EP 2321 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 856YH UT WOS:000297680300009 ER PT J AU Loria, CM Mussolino, ME Cogswell, ME Gillespie, C Gunn, JP Labarthe, DR Saydah, S Pavkov, ME AF Loria, Catherine M. Mussolino, Michael E. Cogswell, Mary E. Gillespie, Cathleen Gunn, Janelle P. Labarthe, Darwin R. Saydah, Sharon Pavkov, Meda E. TI Usual Sodium Intakes Compared With Current Dietary Guidelines-United States, 2005-2008 (Reprinted from MMWR, vol 60, pg 1413-1417, 2011) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Cogswell, Mary E.; Gillespie, Cathleen; Gunn, Janelle P.; Labarthe, Darwin R.] CDC, Div Heart Dis & Stroke Prevent, Atlanta, GA 30333 USA. [Loria, Catherine M.; Mussolino, Michael E.] NHLBI, Div Cardiovasc Dis, NIH, Bethesda, MD 20892 USA. [Saydah, Sharon; Pavkov, Meda E.] CDC, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. RP Cogswell, ME (reprint author), CDC, Div Heart Dis & Stroke Prevent, Atlanta, GA 30333 USA. EM mcogswell@cdc.gov NR 1 TC 0 Z9 0 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 7 PY 2011 VL 306 IS 21 BP 2322 EP 2324 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 856YH UT WOS:000297680300010 ER PT J AU Chaves, SS Daniels, D Cooper, BW Malo-Schlegel, S MacArthur, S Robbins, KC Kobetitsch, JF McDaniel, A D'Avella, JF Alter, MJ AF Chaves, Sandra S. Daniels, Danni Cooper, Brian W. Malo-Schlegel, Susan MacArthur, Susan Robbins, Karen C. Kobetitsch, John F. McDaniel, Aimee D'Avella, John F. Alter, Miriam J. TI Immunogenicity of hepatitis B vaccine among hemodialysis patients: Effect of revaccination of non-responders and duration of protection SO VACCINE LA English DT Article DE Hepatitis B virus; Hepatitis B vaccine; Immunogenicity; Duration of vaccine-induced antibody; Hemodialysis patients ID PATIENTS RECEIVING HEMODIALYSIS; LONG-TERM IMMUNOGENICITY; VIRUS-INFECTION; UNITED-STATES; EFFICACY; DNA AB Background: Hepatitis B vaccination is recommended for patients on hemodialysis, however, seroprotection after a primary vaccine series is suboptimum. Limited data are available on the effect of revaccination of non-responders and on persistence of immunity in this population. Methods: Hepatitis B vaccine (40 mu g/dose) was given to 77 susceptible patients on hemodialysis (0, 1, and 6 month schedule). Levels of hepatitis B surface antibody (anti-HBs) were tested >= 28 days after the third dose was administered, and non-responders revaccinated with an additional 3-dose series. Vaccine responders (anti-HBs >= 10 mIU/mL) were re-tested every 6 months and booster doses given as needed. Kaplan-Meier survival curve was used to estimate the probability of maintaining protective antibody level. Cox-proportional hazards models were used to assess the association between time to loss of protective antibody levels and certain explanatory variables. Results: Overall primary vaccine-induced response was 79.2% (95% CI 68.2%, 87.3%), including 49/77 (63.6%; 95% CI 51.8%, 74.7%) patients who received the initial primary hepatitis B vaccine series and 12/21 (57.1%; 95% CI 34.4%, 77.4%) non-responders who were revaccinated with an additional series. Among weak responders (anti-HBs level 10.0-99.9 mIU/mL), protective antibody levels persisted in 44% for 12 months post-vaccination; whereas among strong responders (anti-HBs level >100 mIU/mL), protective antibody levels persisted in 92% for 12 months, and 68% for 24 months post-vaccination. A weak post-vaccination response increased the risk of losing protective antibody levels (adjusted hazard ratio, 9.7; 95% confidence interval, 3.5-28.5; p<0.0001). Conclusion: Revaccinating patients undergoing hemodialysis who do not respond to a primary vaccine series substantially increases the pool of protected patients. The threshold for defining hepatitis B vaccine-induced immunity should be revisited in this patient population to maximize the duration of protection. Published by Elsevier Ltd. C1 [Chaves, Sandra S.; Daniels, Danni] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Cooper, Brian W.; Malo-Schlegel, Susan; Robbins, Karen C.; Kobetitsch, John F.; McDaniel, Aimee] Hartford Hosp, Hartford, CT 06115 USA. [Cooper, Brian W.; D'Avella, John F.] Univ Connecticut, Sch Med, Storrs, CT USA. [MacArthur, Susan] Connecticut Childrens Med Ctr, Hartford, CT USA. [Alter, Miriam J.] Univ Texas Med Branch, Galveston, TX USA. RP Chaves, SS (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,MS A-20, Atlanta, GA 30333 USA. EM schaves@cdc.gov NR 31 TC 13 Z9 14 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD DEC 6 PY 2011 VL 29 IS 52 BP 9618 EP 9623 DI 10.1016/j.vaccine.2011.10.057 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 869UF UT WOS:000298623000012 PM 22044739 ER PT J AU Penfold, RB Rusinak, D Lieu, TA Shefer, A Messonnier, M Lee, GM AF Penfold, Robert B. Rusinak, Donna Lieu, Tracy A. Shefer, Abigail Messonnier, Mark Lee, Grace M. TI Financing and systems barriers to seasonal influenza vaccine delivery in community settings SO VACCINE LA English DT Article DE Vaccine delivery; Vaccine financing; Public health; Reimbursement; Community settings ID IMMUNIZATION PRACTICES ACIP; UNITED-STATES; ADVISORY-COMMITTEE; YOUNG-CHILDREN; BURDEN; RECOMMENDATIONS; PREVENTION; REIMBURSEMENT; COVERAGE; ADULTS AB Background: Recommendations for annual seasonal influenza vaccination have expanded to now include >300 million children and adults each year. Community settings have become increasingly important venues for influenza vaccination. We sought to identify barriers to and solutions for expanding influenza vaccination in community settings. Methods: Semi-structured telephone interviews were conducted from 01/09 to 06/10 with a range of stakeholders involved in influenza vaccination, including health plans, medical services firms, retail based clinics, pharmacies, schools, and state and local public health immunization programs. Participants (n = 65) were asked about barriers and feasible solutions to influenza vaccine delivery to children and adults in community settings. Key themes were identified through iterative coding using a grounded theory approach. Results: Stakeholders identified specific financial barriers to influenza vaccine delivery in 3 major areas: purchase and distribution, delivery, and reimbursement. Limited purchasing power, the uncertain nature of public demand, and unpredictable timing of influenza vaccine supply were important barriers to enhance delivery in community settings. Barriers to delivery included complexities in running off-site clinics, especially in school settings, the need to manage publicly vs. privately purchased vaccines separately, and state-to-state variability in requirements for credentialing, physician oversight, and reporting. Reimbursement barriers included a protracted credentialing process, the need to determine insurance eligibility at point-of-service, and lack of a billing infrastructure in off-site clinics. Opportunities to mitigate financial barriers to influenza vaccine delivery in community settings focused on coordination across providers and the role of public health as a "trusted broker" to overcome existing challenges. Conclusions: Financial and systems barriers hamper the optimal use of community settings to effectively deliver influenza vaccines. Public health partners at the federal, state, and local levels are well-positioned to facilitate the engagement of all stakeholders in this important and complex vaccine delivery system. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Penfold, Robert B.; Rusinak, Donna; Lieu, Tracy A.; Lee, Grace M.] Harvard Pilgrim Hlth Care Inst, Dept Populat Med, Ctr Child Hlth Care Studies, Boston, MA 02215 USA. [Penfold, Robert B.; Rusinak, Donna; Lieu, Tracy A.; Lee, Grace M.] Harvard Univ, Sch Med, Boston, MA 02215 USA. [Penfold, Robert B.] Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA. [Lieu, Tracy A.] Childrens Hosp Boston, Div Gen Pediat, Boston, MA USA. [Shefer, Abigail; Messonnier, Mark] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Lee, Grace M.] Childrens Hosp Boston, Div Infect Dis, Boston, MA USA. [Lee, Grace M.] Childrens Hosp Boston, Dept Lab Med, Boston, MA USA. RP Lee, GM (reprint author), Harvard Pilgrim Hlth Care Inst, Dept Populat Med, Ctr Child Hlth Care Studies, 133 Brookline Ave,6th Floor, Boston, MA 02215 USA. EM grace.lee@childrens.harvard.edu FU Joint Initiative for Vaccine Economics (JIVE3) [U01 IP000143]; Centers for Disease Control and Prevention; Agency for Healthcare Research and Quality [K-08 HS013908-01 A1] FX This study was funded by the Joint Initiative for Vaccine Economics (JIVE3) grant U01 IP000143 from the Centers for Disease Control and Prevention. Dr. Lee was also supported by grant K-08 HS013908-01 A1 from the Agency for Healthcare Research and Quality. NR 29 TC 5 Z9 5 U1 0 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD DEC 6 PY 2011 VL 29 IS 52 BP 9632 EP 9639 DI 10.1016/j.vaccine.2011.10.041 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 869UF UT WOS:000298623000014 PM 22036886 ER PT J AU Whiteman, MC Wicker, JA Kinney, RM Huang, CYH Solomon, T Barrett, ADT AF Whiteman, Melissa C. Wicker, Jason A. Kinney, Richard M. Huang, Claire Y. -H. Solomon, Tom Barrett, Alan D. T. TI Multiple amino acid changes at the first glycosylation motif in NS1 protein of West Nile virus are necessary for complete attenuation for mouse neuroinvasiveness SO VACCINE LA English DT Article DE West Nile virus; Attenuation; Glycosylation; NS1 ID DENGUE HEMORRHAGIC-FEVER; TICK-BORNE ENCEPHALITIS; FLACCID PARALYSIS; MUTANT VIRUSES; INFECTION; MANIFESTATIONS; IDENTIFICATION; CONSTRUCTION; HEMISPHERE; STRAINS AB West Nile virus (WNV), like all members of the Japanese encephalitis (JE) serogroup except JE virus, contains three N-linked glycosylation (N-X-S/T) sites in the NS1 protein at asparagine residues NS1(130), NS1(175) and NS1(207). Previously we showed that the ablation of these glycosylation sites in WNV, by substitution of asparagine for alanine, attenuated mouse neuroinvasiveness: however, full attenuation was not achieved and the virus retained a neurovirulence phenotype. Sequence of viral RNA extracted from mouse brains revealed a reversion at the NS1(130) site in some mice that succumbed to the attenuated NS1(130/175A/207A) strain. Here, we further attenuated WNV by mutating the asparagine to serine or glutamine in addition to mutating other residues in the NS1(130-132) glycosylation motif. These mutants proved to further attenuate WNV for both neuroinvasiveness and neurovirulence in mice. NS1(130-132QQA/175A/207A). the most attenuated mutant virus, showed modest changes in infectivity titers versus the parental strain, was not temperature sensitive, and did not show reversion in mice. Mutant virus was completely attenuated for neuroinvasiveness after intraperitoneal inoculation with >1,000,000 PFU, and mice were protected against lethal challenge. Overall, we showed that changing the asparagine of the NS1(130) glycosylation motif to a serine or glutamine attenuated WNV further than the asparagine to alanine substitution. Further, mutating all three of the amino acids of the NS1(130-132) glycosylation motif (NTT-QQA) along with NS1(175) and NS1(207) asparagine to alanine mutations gave the most stable and attenuated strain. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Barrett, Alan D. T.] Univ Texas Med Branch, Dept Pathol, Sealy Ctr Vaccine Dev, Ctr Biodef & Emerging Infect Dis,Inst Human Infec, Galveston, TX 77555 USA. [Kinney, Richard M.; Huang, Claire Y. -H.] Ctr Dis Control & Prevent, Div Vector Borne Infect, Ft Collins, CO USA. [Solomon, Tom] Univ Liverpool, Brain Infect Grp, Inst Infect & Global Hlth, Liverpool L69 3BX, Merseyside, England. RP Barrett, ADT (reprint author), Univ Texas Med Branch, Dept Pathol, Sealy Ctr Vaccine Dev, Ctr Biodef & Emerging Infect Dis,Inst Human Infec, 301 Univ Blvd, Galveston, TX 77555 USA. EM abarrett@utmb.edu OI Solomon, Tom/0000-0001-7266-6547 FU Clayton Foundation for Research FX This work was funded in part by the Clayton Foundation for Research. NR 34 TC 19 Z9 19 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD DEC 6 PY 2011 VL 29 IS 52 BP 9702 EP 9710 DI 10.1016/j.vaccine.2011.09.036 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 869UF UT WOS:000298623000024 PM 21945257 ER PT J AU Clementi, N De Marco, D Mancini, N Solforosi, L Moreno, GJ Gubareva, LV Mishin, V Di Pietro, A Vicenzi, E Siccardi, AG Clementi, M Burioni, R AF Clementi, Nicola De Marco, Donata Mancini, Nicasio Solforosi, Laura Moreno, Guisella J. Gubareva, Larisa V. Mishin, Vasiliy Di Pietro, Andrea Vicenzi, Elisa Siccardi, Antonio G. Clementi, Massimo Burioni, Roberto TI A Human Monoclonal Antibody with Neutralizing Activity against Highly Divergent Influenza Subtypes SO PLOS ONE LA English DT Article ID H1N1 2009 VIRUS; A VIRUSES; SEASONAL INFLUENZA; B-CELLS; S-OIV; PROTECTION; OSELTAMIVIR; INFECTION; VACCINE; EPITOPE AB The interest in broad-range anti-influenza A monoclonal antibodies (mAbs) has recently been strengthened by the identification of anti-hemagglutinin (HA) mAbs endowed with heterosubtypic neutralizing activity to be used in the design of "universal" prophylactic or therapeutic tools. However, the majority of the single mAbs described to date do not bind and neutralize viral isolates belonging to highly divergent subtypes clustering into the two different HA-based influenza phylogenetic groups: the group 1 including, among others, subtypes H1, H2, H5 and H9 and the group 2 including, among others, H3 subtype. Here, we describe a human mAb, named PN-SIA28, capable of binding and neutralizing all tested isolates belonging to phylogenetic group 1, including H1N1, H2N2, H5N1 and H9N2 subtypes and several isolates belonging to group 2, including H3N2 isolates from the first period of the 1968 pandemic. Therefore, PN-SIA28 is capable of neutralizing isolates belonging to subtypes responsible of all the reported pandemics, as well as other subtypes with pandemic potential. The region recognized by PN-SIA28 has been identified on the stem region of HA and includes residues highly conserved among the different influenza subtypes. A deep characterization of PN-SIA28 features may represent a useful help in the improvement of available anti-influenza therapeutic strategies and can provide new tools for the development of universal vaccinal strategies. C1 [Clementi, Nicola; De Marco, Donata; Mancini, Nicasio; Solforosi, Laura; Moreno, Guisella J.; Clementi, Massimo; Burioni, Roberto] Univ Vita Salute San Raffaele, Lab Microbiol & Virol, Milan, Italy. [Gubareva, Larisa V.; Mishin, Vasiliy] Ctr Dis Control & Prevent, Virus Surveillance & Diag Branch, Influenza Div, NCIRD, Atlanta, GA USA. [Di Pietro, Andrea; Vicenzi, Elisa] Ist Sci San Raffaele, Viral Pathogens & Biosafety Unit, Div Immunol Trapianti & Malattie Infett, Milan, Italy. [Siccardi, Antonio G.] Univ Milan, Dipartimento Biol & Genet Sci Med, Milan, Italy. RP Clementi, N (reprint author), Univ Vita Salute San Raffaele, Lab Microbiol & Virol, Milan, Italy. EM burioni.roberto@hsr.it RI Burioni, Roberto /F-2396-2012; Clementi, Massimo/F-6646-2013; Clementi, Nicola/G-8545-2014; OI Clementi, Nicola/0000-0002-1822-9861; Di Pietro, Andrea/0000-0003-2497-3862; Clementi, Massimo/0000-0002-7461-5898; MANCINI, Nicasio/0000-0003-0637-0910; Vicenzi, Elisa/0000-0003-0051-3968 NR 41 TC 38 Z9 39 U1 2 U2 17 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 5 PY 2011 VL 6 IS 12 AR e28001 DI 10.1371/journal.pone.0028001 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 863NX UT WOS:000298172800008 PM 22162996 ER PT J AU Nizame, FA Nasreen, S Unicomb, L Southern, D Gurley, ES Arman, S Kadir, MA Azziz-Baumgartner, E Luby, SP Winch, PJ AF Nizame, Fosiul A. Nasreen, Sharifa Unicomb, Leanne Southern, Dorothy Gurley, Emily S. Arman, Shaila Kadir, Mohammad A. Azziz-Baumgartner, Eduardo Luby, Stephen P. Winch, Peter J. TI Understanding community perceptions, social norms and current practice related to respiratory infection in Bangladesh during 2009: a qualitative formative study SO BMC PUBLIC HEALTH LA English DT Article DE Non-pharmaceutical intervention; Pandemic; Influenza; Coughing; Sneezing; Respiratory hygiene ID RURAL BANGLADESH; PREVENTION; INFLUENZA; VIRUS; URBAN AB Background: Respiratory infections are the leading cause of childhood deaths in Bangladesh. Promoting respiratory hygiene may reduce infection transmission. This formative research explored community perceptions about respiratory infections. Methods: We conducted 34 in-depth interviews and 16 focus group discussions with community members and school children to explore respiratory hygiene related perceptions, practices, and social norms in an urban and a rural setting. We conducted unstructured observations on respiratory hygiene practices in public markets. Results: Informants were not familiar with the term "respiratory infection"; most named diseases that had no relation to respiratory dysfunction. Informants reported that their community identified a number of 'good behaviors' related to respiratory hygiene, but they also noted, and we observed, that very few people practiced these. All informants cited hot/cold weather changes or using cold water as causes for catching cold. They associated transmission of respiratory infections with close contact with a sick person's breath, cough droplets, or spit; sharing a sick person's utensils and food. Informants suggested that avoiding such contact was the most effective method to prevent respiratory infection. Although informants perceived that handwashing after coughing or sneezing might prevent illness, they felt this was not typically feasible or practical. Conclusion: Community perceptions of respiratory infections include both concerns with imbalances between hot and cold, and with person-to-person transmission. Many people were aware of measures that could prevent respiratory infection, but did not practice them. Interventions that leverage community understanding of person-to-person transmission and that encourage the practice of their identified 'good behaviors' related to respiratory hygiene may reduce respiratory disease transmission. C1 [Nizame, Fosiul A.; Nasreen, Sharifa; Unicomb, Leanne; Southern, Dorothy; Gurley, Emily S.; Arman, Shaila; Kadir, Mohammad A.; Azziz-Baumgartner, Eduardo; Luby, Stephen P.] ICDDR B, Dhaka, Bangladesh. [Azziz-Baumgartner, Eduardo; Luby, Stephen P.] Ctr Dis Control & Prevent CDC, Atlanta, GA USA. [Winch, Peter J.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. RP Nizame, FA (reprint author), ICDDR B, Dhaka, Bangladesh. EM fosiul@icddrb.org RI Gurley, Emily/B-7903-2010 OI Gurley, Emily/0000-0002-8648-9403 FU Johns Hopkins Bloomberg School of Public Health; US Agency for International Development (USAID) [GHS-A-00-03-0019-00] FX This research study was supported by a sub-agreement from Johns Hopkins Bloomberg School of Public Health with funds provided by Cooperative Agreement No. GHS-A-00-03-0019-00 from the US Agency for International Development (USAID). icddr, b acknowledges with gratitude the commitment of USAID to its research efforts. NR 22 TC 3 Z9 3 U1 2 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD DEC 4 PY 2011 VL 11 AR 901 DI 10.1186/1471-2458-11-901 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 892JW UT WOS:000300283500001 PM 22136080 ER PT J AU Nair, H Brooks, WA Katz, M Roca, A Berkley, JA Madhi, SA Simmerman, JM Gordon, A Sato, M Howie, S Krishnan, A Ope, M Lindblade, KA Carosone-Link, P Lucero, M Ochieng, W Kamimoto, L Dueger, E Bhat, N Vong, S Theodoratou, E Chittaganpitch, M Chimah, O Balmaseda, A Buchy, P Harris, E Evans, V Katayose, M Gaur, B O'Callaghan-Gordo, C Goswami, D Arvelo, W Venter, M Briese, T Tokarz, R Widdowson, MA Mounts, AW Breiman, RF Feikin, DR Klugman, KP Olsen, SJ Gessner, BD Wright, PF Rudan, I Broor, S Simoes, EAF Campbell, H AF Nair, Harish Brooks, W. Abdullah Katz, Mark Roca, Anna Berkley, James A. Madhi, Shabir A. Simmerman, James Mark Gordon, Aubree Sato, Masatoki Howie, Stephen Krishnan, Anand Ope, Maurice Lindblade, Kim A. Carosone-Link, Phyllis Lucero, Marilla Ochieng, Walter Kamimoto, Laurie Dueger, Erica Bhat, Niranjan Vong, Sirenda Theodoratou, Evropi Chittaganpitch, Malinee Chimah, Osaretin Balmaseda, Angel Buchy, Philippe Harris, Eva Evans, Valerie Katayose, Masahiko Gaur, Bharti O'Callaghan-Gordo, Cristina Goswami, Doli Arvelo, Wences Venter, Marietjie Briese, Thomas Tokarz, Rafal Widdowson, Marc-Alain Mounts, Anthony W. Breiman, Robert F. Feikin, Daniel R. Klugman, Keith P. Olsen, Sonja J. Gessner, Bradford D. Wright, Peter F. Rudan, Igor Broor, Shobha Simoes, Eric A. F. Campbell, Harry TI Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta-analysis SO LANCET LA English DT Review ID COMMUNITY-ACQUIRED PNEUMONIA; HUMAN-IMMUNODEFICIENCY-VIRUS; SYNCYTIAL VIRUS; HUMAN METAPNEUMOVIRUS; TRACT INFECTIONS; VIRAL ETIOLOGY; UNITED-STATES; STREPTOCOCCUS-PNEUMONIAE; PNEUMOCOCCAL PNEUMONIA; CHILDHOOD PNEUMONIA AB Background The global burden of disease attributable to seasonal influenza virus in children is unknown. We aimed to estimate the global incidence of and mortality from lower respiratory infections associated with influenza in children younger than 5 years. Methods We estimated the incidence of influenza episodes, influenza-associated acute lower respiratory infections (ALRI), and influenza-associated severe ALRI in children younger than 5 years, stratified by age, with data from a systematic review of studies published between Jan 1, 1995, and Oct 31, 2010, and 16 unpublished population-based studies. We applied these incidence estimates to global population estimates for 2008 to calculate estimates for that year. We estimated possible bounds for influenza-associated ALRI mortality by combining incidence estimates with case fatality ratios from hospital-based reports and identifying studies with population-based data for influenza seasonality and monthly ALRI mortality. Findings We identified 43 suitable studies, with data for around 8 million children. We estimated that, in 2008, 90 million (95% CI 49-162 million) new cases of influenza (data from nine studies), 20 million (13-32 million) cases of influenza-associated ALRI (13% of all cases of paediatric ALRI; data from six studies), and 1 million (1-2 million) cases of influenza-associated severe ALRI (7% of cases of all severe paediatric ALRI; data from 39 studies) occurred worldwide in children younger than 5 years. We estimated there were 28 000-111 500 deaths in children younger than 5 years attributable to influenza-associated ALRI in 2008, with 99% of these deaths occurring in developing countries. Incidence and mortality varied substantially from year to year in any one setting. Interpretation Influenza is a common pathogen identified in children with ALRI and results in a substantial burden on health services worldwide. Sufficient data to precisely estimate the role of influenza in childhood mortality from ALRI are not available. C1 [Nair, Harish] Univ Edinburgh, Ctr Populat Hlth Sci, Sch Med, Global Hlth Acad, Edinburgh EH8 9AG, Midlothian, Scotland. [Nair, Harish] Publ Hlth Fdn India, New Delhi, India. [Brooks, W. Abdullah; Goswami, Doli] Int Ctr Diarrhoeal Dis Res, Dhaka 1000, Bangladesh. [Katz, Mark; Breiman, Robert F.; Feikin, Daniel R.] Kenya Govt Med Res Ctr, Nairobi, Kenya. [Katz, Mark; Breiman, Robert F.; Feikin, Daniel R.] Ctr Dis Control & Prevent Kenya, Nairobi, Kenya. [Roca, Anna; O'Callaghan-Gordo, Cristina] Univ Barcelona, Ctr Int Hlth Res CRESIB, Hosp Clin, IDIBAPS, Barcelona, Spain. [Berkley, James A.] Ctr Geog Med Res Coast, Kilin, Kenya. [Berkley, James A.] Univ Oxford, Ctr Clin Vaccinol & Trop Med, Oxford, England. [Madhi, Shabir A.] Univ Witwatersrand, Med Res Council, Resp & Meningeal Pathogens Res Unit, ZA-2050 Wits, South Africa. [Madhi, Shabir A.] Univ Witwatersrand, Dept Sci & Technol, ZA-2050 Wits, South Africa. [Madhi, Shabir A.] Univ Witwatersrand, Natl Res Fdn Vaccine Preventable Dis, ZA-2050 Wits, South Africa. [Simmerman, James Mark; Olsen, Sonja J.] US Ctr Dis Control & Prevent Thailand, Div & Int Emerging Infect Program, MOPH Collaborat, Nonthaburi, Thailand. [Gordon, Aubree; Harris, Eva] Univ Calif Berkeley, Div Infect Dis & Vaccinol, Berkeley, CA 94720 USA. [Gordon, Aubree] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Sato, Masatoki] Fukushima Med Univ, Dept Paediat, Sch Med, Fukushima, Japan. [Howie, Stephen; Chimah, Osaretin] Med Res Council UK Labs, Banjul, Gambia. [Krishnan, Anand; Gaur, Bharti] All India Inst Med Sci, New Delhi, India. [Lindblade, Kim A.; Arvelo, Wences] Ctr Dis Control & Prevent, Global Dis Detect Program, Reg Off Cent Amer & Panama, Guatemala City, Guatemala. [Carosone-Link, Phyllis; Simoes, Eric A. F.] Univ Colorado, Denver, CO 80202 USA. [Lindblade, Kim A.; Simoes, Eric A. F.] Childrens Hosp, Denver, CO 80218 USA. [Ochieng, Walter] Kenya Govt Med Res Ctr, Ctr Virus Res, Nairobi, Kenya. [Kamimoto, Laurie; Widdowson, Marc-Alain] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Dueger, Erica] Global Dis Detect & Response Ctr, Naval Med Res Unit 3, Cairo, Egypt. [Bhat, Niranjan] Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Amer Indian Hlth, Baltimore, MD USA. [Chittaganpitch, Malinee] Minist Publ Hlth, Natl Inst Hlth, Nonthaburi, Thailand. [Chimah, Osaretin] Med Ctr, Asaba, Delta State, Nigeria. [Katayose, Masahiko] Soma Gen Hosp, Dept Paediat, Soma, Japan. [Venter, Marietjie] Natl Inst Communicable Dis, Resp Virus Unit, Natl Inflenza Ctr, Natl Hlth Lab Serv, Johannesburg, South Africa. [Venter, Marietjie] Univ Pretoria, Resp & Zoonot Virus Programme, Dept Med Virol, ZA-0002 Pretoria, South Africa. [Briese, Thomas; Tokarz, Rafal] Columbia Univ, Ctr Infect & Immun, Mailman Sch Publ Hlth, New York, NY USA. [Mounts, Anthony W.] World Hlth Org, Global Influenza Program, Geneva, Switzerland. [Klugman, Keith P.] Emory Univ, Dept Global Hlth, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Klugman, Keith P.] Emory Univ, Div Infect Dis, Sch Med, Atlanta, GA 30322 USA. [Gessner, Bradford D.] Agence Med Prevent, Paris, France. [Wright, Peter F.] Dartmouth Med Sch, Div Infect Dis & Int Hlth, Lebanon, NH USA. [Rudan, Igor] Univ Split, Croatian Ctr Global Hlth, Fac Med, Split, Croatia. [Simoes, Eric A. F.] Univ Padjadjaram, Bandung, Indonesia. RP Nair, H (reprint author), Univ Edinburgh, Ctr Populat Hlth Sci, Sch Med, Global Hlth Acad, Teviot Pl, Edinburgh EH8 9AG, Midlothian, Scotland. EM harish.nair@ed.ac.uk; harry.campbell@ed.ac.uk RI Nair, Harish/E-7431-2010; Krishnan, Anand/D-8537-2012; Rudan, Igor/I-1467-2012; Theodoratou, Evropi/C-3430-2014; Venter, Marietjie/P-9604-2016; OI Nair, Harish/0000-0002-9432-9100; Rudan, Igor/0000-0001-6993-6884; Theodoratou, Evropi/0000-0001-5887-9132; Venter, Marietjie/0000-0003-2696-824X; Widdowson, Marc-Alain/0000-0002-0682-6933; O'Callaghan-Gordo, Cristina/0000-0002-4229-2991; Gordon, Aubree/0000-0002-9352-7877; Berkley, James/0000-0002-1236-849X; Krishnan, Anand/0000-0002-9173-7811 FU WHO [HQGIP1002906]; Bill & Melinda Gates Foundation [51285]; Wyeth; Pfizer; GSK; Sanofi Pasteur; GlaxoSmithKline; Merck; MedImmune; Roche; Aventis Pasteur; Evans-Powderject; US Centers for Disease Control and Prevention (CDC); Indian Council of Medical Research FX WHO; Bill & Melinda Gates Foundation.; SAM has received research funding from Wyeth for the Soweto study that contributed to the data. He has received consultancy from Pfizer, GSK, and Novartis and speaker fees from Pfizer and GSK. However, no honoraria were received for work included in this study. BDG has received consultancy from WHO and a travel grant from Sanofi Pasteur to attend a conference on influenza in 2010. He is employed by Agence de Medecine Preventive, which has received funding from WHO, Pfizer, GlaxoSmithKline, and Merck. In 2010, the Agence de Medecine Preventive was hired by Sanofi Pasteur to organize a conference on influenza. However, no grants or honoraria were received for work included in this study. EAFS has received speaker fees and consultancy from MedImmune and research grants from Roche and MedImmune. However, no grants or honoraria were received for work included in this study. NB is employed by Johns Hopkins University which has received funding from Aventis Pasteur and Evans-Powderject. All other authors declare that they have no conflicts of interest.; Financial support for this work was provided by WHO Global Influenza Program (grant number HQGIP1002906) and the Bill & Melinda Gates Foundation (grant number 51285). The study in Ballabgarh, India, received financial support from US Centers for Disease Control and Prevention (CDC) and Indian Council of Medical Research. This work was done as part of the wider programme of the Child Health Epidemiology Working Group (CHERG) to establish the major causes of global childhood disease burden. Walter Ochieng sadly died suddenly and unexpectedly while this paper was being prepared for publication. We would like to acknowledge his important contribution to this study and his role in strengthening influenza surveillance in Kenya. We thank Johannes Forster (Department of Paediatrics, St Josefskrankenhaus Freiburg and University of Freiburg, Freiburg, Germany), Gabriele Ihorst (Clinical Trials Center, University Medical Centre Freiburg, Freiburg, Germany), Terho Heikkinen (Turku University Hospital, Turku, Finland), Alex Ezeh, Samuel Oti, and Catherine Kyobutungi (African Population and Health Research Centre, Nairobi, Kenya), and the Influenza Emerging Infections Program Network, USA for providing additional data from their published papers; Vivek Gupta and Sanjay K Rai (Comprehensive Rural Health Services Project, Ballabgarh and All India Institute of Medical Sciences, New Delhi, India); Samander Kaushik and Yashpal Singh (Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India); National Institute of Virology, Pune, India; Wallace D Bulimo (National Influenza Centre, Nairobi, Kenya); Respiratory and Zoonosis group, Department of Medical Virology, University of Pretoria, South Africa; D James Nokes (KEMRI, Kilifi, Kenya); Locadiah Kuwanda (Chris Hani Baragwanath Hospital, Johannesburg, South Africa); Pedro L Alonso, Ll Quinto, Q Bassat (CRESIB, Hospital Clinic/IDIBAPS, Universitat de Barcelona, Barcelona, Spain and Centro de Investigacao em Saude da Manhica, Ministerio de Saude, Maputo, Mozambique); Jens Levy (Influenza Division and International Emerging Infections Program, US CDC-Thailand MOPH Collaboration, Nonthaburi, Thailand); Alejandra Estevez, Fabiola Moscoso, and Jennifer Gray (Centro de Estudios en Salud, Universidad del Valle de Guatemala); Lissette Reyes, Juan Carlos Moir (Ministerio de Salud Publica y Asistencia Social, Guatemala); Alicia M Fry (Influenza Division, CDC, Atlanta, USA); Hanna Nohynek, Taneli Puumalainen and Petri Ruutu (National Institute for Health and Welfare, Finland); Leilani Nillos (Research Institute for Tropical Medicine, Department of Health, Alabang, Muntinlupa, Philippines) and ARIVAC consortium; Ian Lipkin (University of Columbia, New York); Gerard Morris (University Witwatersrand, South Africa); Grant Mackenzie, Readon Ideh, Bernard Ebruke, Claire Oluwalana (MRC, Gambia) and the Gambia Severe Pneumonia Studies Group; Karen Fowler (University of Alabama at Birmingham, Birmingham, AL, USA); Katherine O'Brien (Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA) for their assistance; Jian Shayne F Zhang (Centre for Population Health Sciences, The University of Edinburgh, UK) for doing the literature search in Chinese language databases; Carolyn B Bridges (Influenza Division, National Center for Immunizations and Respiratory Disease, CDC, Atlanta, GA, USA) for critically reviewing the manuscript and providing helpful comments.; The findings and conclusions in this report are those of the authors and do not necessarily represent he views of the US CDC or WHO. NR 89 TC 229 Z9 238 U1 2 U2 44 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0140-6736 J9 LANCET JI Lancet PD DEC 3 PY 2011 VL 378 IS 9807 BP 1917 EP 1930 DI 10.1016/S0140-6736(11)61051-9 PG 14 WC Medicine, General & Internal SC General & Internal Medicine GA 863AW UT WOS:000298136200026 PM 22078723 ER PT J AU Hutson, CL Carroll, DS Gallardo-Romero, N Weiss, S Clemmons, C Hughes, CM Salzer, JS Olson, VA Abel, J Karem, KL Damon, IK AF Hutson, Christina L. Carroll, Darin S. Gallardo-Romero, Nadia Weiss, Sonja Clemmons, Cody Hughes, Christine M. Salzer, Johanna S. Olson, Victoria A. Abel, Jason Karem, Kevin L. Damon, Inger K. TI Monkeypox Disease Transmission in an Experimental Setting: Prairie Dog Animal Model SO PLOS ONE LA English DT Article ID CONGO BASIN; VIRUS; OUTBREAK AB Monkeypox virus (MPXV) is considered the most significant human public health threat in the genus Orthopoxvirus since the eradication of variola virus (the causative agent of smallpox). MPXV is a zoonotic agent endemic to forested areas of Central and Western Africa. In 2003, MPXV caused an outbreak in the United States due to the importation of infected African rodents, and subsequent sequential infection of North American prairie dogs (Cynomys ludovicianus) and humans. In previous studies, the prairie dog MPXV model has successfully shown to be very useful for understanding MPXV since the model emulates key characteristics of human monkeypox disease. In humans, percutaneous exposure to animals has been documented but the primary method of human-to-human MPXV transmission is postulated to be by respiratory route. Only a few animal model studies of MPXV transmission have been reported. Herein, we show that MPXV infected prairie dogs are able to transmit the virus to naive animals through multiple transmission routes. All secondarily exposed animals were infected with MPXV during the course of the study. Notably, animals secondarily exposed appeared to manifest more severe disease; however, the disease course was very similar to those of experimentally challenged animals including inappetence leading to weight loss, development of lesions, production of orthopoxvirus antibodies and shedding of similar levels or in some instances higher levels of MPXV from the oral cavity. Disease was transmitted via exposure to contaminated bedding, co-housing, or respiratory secretions/nasal mucous (we could not definitively say that transmission occurred via respiratory route exclusively). Future use of the model will allow us to evaluate infection control measures, vaccines and antiviral strategies to decrease disease transmission. C1 [Hutson, Christina L.; Carroll, Darin S.; Gallardo-Romero, Nadia; Weiss, Sonja; Clemmons, Cody; Hughes, Christine M.; Salzer, Johanna S.; Olson, Victoria A.; Abel, Jason; Karem, Kevin L.; Damon, Inger K.] Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Dis, Atlanta, GA 30333 USA. [Salzer, Johanna S.] Emory Univ, Program Populat Biol Ecol & Evolut, Atlanta, GA 30322 USA. RP Hutson, CL (reprint author), Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Dis, Atlanta, GA 30333 USA. EM CHutson1@cdc.gov NR 19 TC 9 Z9 9 U1 1 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 2 PY 2011 VL 6 IS 12 AR e28295 DI 10.1371/journal.pone.0028295 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 863NO UT WOS:000298171400064 PM 22164263 ER PT J AU Liu, XD Jiang, BF Gu, WD Liu, QY AF Liu, Xiaodong Jiang, Baofa Gu, Weidong Liu, Qiyong TI Temporal trend and climate factors of hemorrhagic fever with renal syndrome epidemic in Shenyang City, China SO BMC INFECTIOUS DISEASES LA English DT Article ID HANTAVIRUSES; VARIABLES; RESERVOIR; PROVINCE; RISK AB Background: Hemorrhagic fever with renal syndrome (HFRS) is an important infectious disease caused by different species of hantaviruses. As a rodent-borne disease with a seasonal distribution, external environmental factors including climate factors may play a significant role in its transmission. The city of Shenyang is one of the most seriously endemic areas for HFRS. Here, we characterized the dynamic temporal trend of HFRS, and identified climate-related risk factors and their roles in HFRS transmission in Shenyang, China. Methods: The annual and monthly cumulative numbers of HFRS cases from 2004 to 2009 were calculated and plotted to show the annual and seasonal fluctuation in Shenyang. Cross-correlation and autocorrelation analyses were performed to detect the lagged effect of climate factors on HFRS transmission and the autocorrelation of monthly HFRS cases. Principal component analysis was constructed by using climate data from 2004 to 2009 to extract principal components of climate factors to reduce co-linearity. The extracted principal components and autocorrelation terms of monthly HFRS cases were added into a multiple regression model called principal components regression model (PCR) to quantify the relationship between climate factors, autocorrelation terms and transmission of HFRS. The PCR model was compared to a general multiple regression model conducted only with climate factors as independent variables. Results: A distinctly declining temporal trend of annual HFRS incidence was identified. HFRS cases were reported every month, and the two peak periods occurred in spring (March to May) and winter (November to January), during which, nearly 75% of the HFRS cases were reported. Three principal components were extracted with a cumulative contribution rate of 86.06%. Component 1 represented MinRH(0), MT(1), RH(1), and MWV(1); component 2 represented RH(2), MaxT(3), and MAP(3); and component 3 represented MaxT(2), MAP(2), and MWV(2). The PCR model was composed of three principal components and two autocorrelation terms. The association between HFRS epidemics and climate factors was better explained in the PCR model (F = 446.452, P < 0.001, adjusted R(2) = 0.75) than in the general multiple regression model (F = 223.670, P < 0.000, adjusted R(2) = 0.51). Conclusion: The temporal distribution of HFRS in Shenyang varied in different years with a distinctly declining trend. The monthly trends of HFRS were significantly associated with local temperature, relative humidity, precipitation, air pressure, and wind velocity of the different previous months. The model conducted in this study will make HFRS surveillance simpler and the control of HFRS more targeted in Shenyang. C1 [Liu, Xiaodong; Jiang, Baofa] Shandong Univ, Dept Epidemiol & Hlth Stat, Sch Publ Hlth, Jinan, Shandong, Peoples R China. [Liu, Xiaodong; Liu, Qiyong] Natl Inst Communicable Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing, Peoples R China. [Liu, Qiyong] China CDC Key Lab Surveillance & Early Warning In, Beijing, Peoples R China. [Liu, Xiaodong; Jiang, Baofa; Liu, Qiyong] Shandong Univ, Climate Change & Hlth Ctr, Jinan, Shandong, Peoples R China. [Gu, Weidong] Univ Alabama, Med Sch Birmingham, Div Infect Dis, William C Gorgas Ctr Geog Med, Birmingham, AL USA. [Gu, Weidong] NCEZID, EDEB, CDC, Atlanta, GA 30329 USA. RP Jiang, BF (reprint author), Shandong Univ, Dept Epidemiol & Hlth Stat, Sch Publ Hlth, Jinan, Shandong, Peoples R China. EM bjiang@sdu.edu.cn; liuqiyong@icdc.cn FU National Basic Research Program of China (973 Program) [2012CB955500]; Ministry of Science & Technology, China [2008ZX10004-010] FX This study was supported by the National Basic Research Program of China (973 Program) (Grant No. 2012CB955500) and Special Infectious Diseases Program of the Ministry of Science & Technology, China(Grant No. 2008ZX10004-010). We would like to thank Miss Fei Zhang and Miss Jingyi Duan for their earnest assistance in revising and editing this manuscript. NR 25 TC 20 Z9 20 U1 2 U2 22 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD DEC 2 PY 2011 VL 11 AR 331 DI 10.1186/1471-2334-11-331 PG 6 WC Infectious Diseases SC Infectious Diseases GA 869JB UT WOS:000298593100001 PM 22133347 ER PT J AU Ioannidis, JPA Khoury, MJ AF Ioannidis, John P. A. Khoury, Muin J. TI Improving Validation Practices in "Omics" Research SO SCIENCE LA English DT Editorial Material ID BIOINFORMATICS; PROTEOMICS AB "Omics" research poses acute challenges regarding how to enhance validation practices and eventually the utility of this rich information. Several strategies may be useful, including routine replication, public data and protocol availability, funding incentives, reproducibility rewards or penalties, and targeted repeatability checks. C1 [Khoury, Muin J.] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA 30333 USA. [Khoury, Muin J.] NCI, Div Canc Control & Populat Sci, NIH, Rockville, MD 20852 USA. [Ioannidis, John P. A.] Stanford Univ, Sch Med, Dept Med, Stanford Prevent Res Ctr, Stanford, CA 94305 USA. [Ioannidis, John P. A.] Stanford Univ, Sch Med, Dept Hlth Res & Policy, Stanford, CA 94305 USA. [Ioannidis, John P. A.] Stanford Univ, Sch Humanities & Sci, Dept Stat, Stanford, CA 94305 USA. RP Khoury, MJ (reprint author), Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA 30333 USA. EM muk1@cdc.gov NR 21 TC 99 Z9 101 U1 0 U2 30 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 J9 SCIENCE JI Science PD DEC 2 PY 2011 VL 334 IS 6060 BP 1230 EP 1232 DI 10.1126/science.1211811 PG 3 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 855HD UT WOS:000297553600037 PM 22144616 ER PT J AU Ford, ES AF Ford, Earl S. TI Trends in the control of risk factors for cardiovascular disease among adults with diagnosed diabetes: Findings from the National Health and Nutrition Examination Survey 1999-2008 SO JOURNAL OF DIABETES LA English DT Article DE blood pressure; body mass index; hemoglobin A1c protein; low-density lipoprotein-cholesterol; smoking ID UNITED-STATES; US ADULTS; TRANSLATING RESEARCH; GLYCEMIC CONTROL; SEX DISPARITIES; MEDICATION USE; PREVALENCE; MELLITUS; CARE; INTERVENTION AB Background: The aim of the present study was to examine trends in the control of key risk factors for cardiovascular disease among adults with diagnosed diabetes in the US from 1999 to 2008. Methods: Data for up to 2623 adults aged 20 years with diagnosed diabetes who participated in 2-year cycles of the National Health and Nutrition Examination Surveys from 1999 to 2008 were examined. Results: Significant improvements were seen in the control of HbA1c (37.0%-55.2%), blood pressure (35.2%-51.0%), and low-density lipoprotein-cholesterol (LDL-C; 32.5%-52.9%). Both men and women experienced significant improvement in HbA1c and LDL-C. Whites showed significant improvement in glycemic control, LDL-C control, and the control of all three risk factors. African Americans showed significant improvement in glycemic control and blood pressure control, and Mexican Americans showed significant improvement in glycemic control and the control of all three risk factors. Compared with Whites, African Americans (prevalence ratio [PR] = 0.84; 95% confidence interval [CI] 0.74-0.96) and Mexican Americans (PR = 0.82; 95% CI 0.72-0.92) had worse glycemic control, and Mexican Americans had worse control of LDL-C (PR = 0.70; 95% CI 0.57-0.87) and of all three risk factors (PR = 0.46; 95% CI 0.23-0.90). There was little change in the prevalence of not currently smoking, having C-reactive protein < 3 g/L, and having a urinary albumin: creatinine ratio < 30 mg/g. The prevalence of body mass index < 30 kg/m(2) decreased from 45.4% to 37.6% (P-linear trend = 0.045). Conclusions: Significant improvements in recommended levels of HbA1c, blood pressure, and LDL-C occurred in diabetic adults in the US between 1999 and 2008. C1 Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Ford, ES (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway,MS K67, Atlanta, GA 30341 USA. EM eford@cdc.gov NR 36 TC 27 Z9 27 U1 1 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1753-0393 J9 J DIABETES JI J. Diabetes PD DEC PY 2011 VL 3 IS 4 BP 337 EP 347 DI 10.1111/j.1753-0407.2011.00148.x PG 11 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 982SJ UT WOS:000307065400013 PM 21767347 ER PT J AU Kroeger, K Taylor, A Marlow, H Fleming, DT Beyleveld, V Alwano, MG Kejelepula, MT Chilume, KB Smith, DK Roels, TH Kilmarx, PH AF Kroeger, Karen Taylor, Allan Marlow, Heather Fleming, Douglas T. Beyleveld, Vanessa Alwano, Mary Grace Kejelepula, Mabel Tebogo Chilume, Kentsenao Busang Smith, Dawn K. Roels, Thierry H. Kilmarx, Peter H. TI Perceptions of door-to-door HIV counselling and testing in Botswana SO SAHARA J-JOURNAL OF SOCIAL ASPECTS OF HIV-AIDS LA English DT Article DE HIV/AIDS; counselling and testing; home-based HIV testing; Botswana; qualitative research ID PERSONS AWARE; RISK; BEHAVIOR; AFRICA; UGANDA; METAANALYSIS; STRATEGIES; INFECTION; KNOWLEDGE; COUNTRIES AB Prevalence of HIV infection in Botswana is among the highest in the world, at 23.9% of 15 - 49-year-olds. Most HIV testing is conducted in voluntary counselling and testing centres or medical settings. Improved access to testing is urgently needed. This qualitative study assessed and documented community perceptions about the concept of door-to-door HIV counselling and rapid testing in two of the highest-prevalence districts of Botswana. Community members associated many positive benefits with home-based, door-to-door HIV testing, including convenience, confidentiality, capacity to increase the number of people tested, and opportunities to increase knowledge of HIV transmission, prevention and care through provision of correct information to households. Community members also saw the intervention as increasing opportunities to engage and influence family members and to role model positive behaviours. Participants also perceived social risks and dangers associated with home-based testing including the potential for conflict, coercion, stigma, and psychological distress within households. Community members emphasised the need for individual and community preparation, including procedures to protect confidentiality, provisions for psychological and social support, and links to appropriate services for HIV-positive persons. C1 [Kroeger, Karen] US Ctr Dis Control & Prevent CDC, Div STD Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent NCH, Atlanta, GA USA. [Taylor, Allan] CDC, Global Programme AIDS, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Marlow, Heather] Univ N Carolina, Dept Maternal & Child Hlth, Chapel Hill, NC USA. [Marlow, Heather] S Africa HIV Antenatal Posttest Support Study, Durban, South Africa. [Fleming, Douglas T.] Bristol Myers Squibb Co, Res & Dev, Global Clin Res Metab Dis, Princeton, NJ USA. [Beyleveld, Vanessa] Premiere Personnel, Gaborone, Botswana. [Kilmarx, Peter H.] CDC, Hlth Reform & Epidemiol Branch, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. RP Kroeger, K (reprint author), US Ctr Dis Control & Prevent CDC, Div STD Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent NCH, Atlanta, GA USA. EM knk2@cdc.gov OI Kilmarx, Peter/0000-0001-6464-3345 NR 34 TC 3 Z9 3 U1 1 U2 8 PU SA MEDICAL ASSOC HEALTH & MEDICAL PUBL GROUP PI CLAREMONT PA 21 DREYER ST, 4TH FLOOR, SANCLARE BLDG, CLAREMONT, 7700, SOUTH AFRICA SN 1729-0376 J9 SAHARA J-J SOC ASP H JI Sahara J-J. Soc. Asp. HIV/AIDS PD DEC PY 2011 VL 8 IS 4 BP 171 EP 178 DI 10.1080/17290376.2011.9725001 PG 8 WC Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA 958QD UT WOS:000305254600002 PM 23236958 ER PT J AU Alemnji, G Nkengasong, JN Parekh, BS AF Alemnji, George Nkengasong, John N. Parekh, Bharat S. TI HIV testing in developing countries: What is required? SO INDIAN JOURNAL OF MEDICAL RESEARCH LA English DT Review DE Accreditation; developing countries; diagnostics; HIV; point of care testing; quality control; rapid tests ID LABORATORY SYSTEMS; SCALING-UP; CHALLENGES; PROGRAMS; QUALITY; HEALTH AB HIV diagnostic and follow up testing are usually done in laboratory settings. However, in developing countries there is a need to decentralize testing as the majority of the population lives in rural settings. In developing countries stringent quality assurance (QA) practices, which include appropriate training, development of standard operating procedures, maintenance of operator proficiency, routine use of quality control (QC) specimens, standardized data management, equipment calibration and maintenance, and biohazard safety with proper disinfection/disposal procedures are not routinely followed to ensure reliability of results and a safe work environment. The introduction of point-of-care testing technologies involving the use of non-laboratorians in routine testing has further increased the complexity of QA. Therefore, a careful approach towards improvement of laboratories that encourages best practices, coupled with incentives, and review of government policies in point-of-care testing is needed to improve quality of testing as decentralization takes place. Development of a functional laboratory tiered network that facilitates communication, referral, training and problem solving could further enhance confidence in laboratory testing. There is also a need for special considerations in implementing a step-wise approach towards quality improvement, strengthening of the supply chain management, human capacity development, infrastructure upgrade, and strong public private partnerships to ensure long term sustainability of these efforts. C1 [Parekh, Bharat S.] Ctr Dis Control & Prevent, Ctr Global Hlth, Atlanta, GA 30329 USA. RP Parekh, BS (reprint author), Ctr Dis Control & Prevent, Ctr Global Hlth, 1600 Clifton Rd,Bldg 15-Room 2611,MS-G19, Atlanta, GA 30329 USA. EM bspl@cdc.gov NR 29 TC 14 Z9 15 U1 0 U2 5 PU INDIAN COUNCIL MEDICAL RES PI NEW DELHI PA PO BOX 4911 ANSARI NAGAR, NEW DELHI 110029, INDIA SN 0971-5916 J9 INDIAN J MED RES JI Indian J. Med. Res. PD DEC PY 2011 VL 134 IS 6 BP 779 EP 786 PG 8 WC Immunology; Medicine, General & Internal; Medicine, Research & Experimental SC Immunology; General & Internal Medicine; Research & Experimental Medicine GA 914QH UT WOS:000301965900006 PM 22310813 ER PT J AU Mariner, JC Hendrickx, S Pfeiffer, DU Costard, S Knopf, L Okuthe, S Chibeu, D Parmley, J Musenero, M Pisang, C Zingeser, J Jones, BA Ali, SN Bett, B McLaws, M Unger, F Araba, A Menta, P Jost, CC AF Mariner, J. C. Hendrickx, S. Pfeiffer, D. U. Costard, S. Knopf, L. Okuthe, S. Chibeu, D. Parmley, J. Musenero, M. Pisang, C. Zingeser, J. Jones, B. A. Ali, S. N. Bett, B. McLaws, M. Unger, F. Araba, A. Menta, P. Jost, C. C. TI Integration of participatory approaches into surveillance systems SO REVUE SCIENTIFIQUE ET TECHNIQUE-OFFICE INTERNATIONAL DES EPIZOOTIES LA English DT Article DE Animal health; Participatory disease surveillance; Participatory epidemiology; Public health; Risk-based; Surveillance ID DISEASE SURVEILLANCE; EPIDEMIOLOGY; HEALTH; APPRAISAL; AFRICA AB Animal health surveillance is essential for protecting public health, enhancing access to international markets for animals and their products, and improving animal health, production and welfare. It is of vital importance for protecting and improving the livelihoods of diverse groups of livestock keepers and stakeholders in livestock value chains. Surveillance systems consist of sets of complementary components which generate information to inform risk assessment, decision-making and policy formulation for both national programmes and international trade. Participatory approaches have the potential to add value to surveillance systems by enhancing their performance, especially their sensitivity and timeliness, and encouraging the inclusion of marginalised groups. This paper summarises key considerations in the assessment and design of animal health surveillance and discusses how participatory approaches can be integrated into comprehensive surveillance systems, leading to a more effective overall outcome for both domestic and international purposes. C1 [Mariner, J. C.; Hendrickx, S.; Jones, B. A.; Ali, S. N.; Bett, B.; McLaws, M.; Unger, F.; Araba, A.; Menta, P.; Jost, C. C.] Int Livestock Res Inst, Nairobi 00100, Kenya. [Pfeiffer, D. U.; Costard, S.; Jones, B. A.] Royal Vet Coll, Vet Epidemiol & Publ Hlth Grp, Hatfield AL9 7TA, Herts, England. [Knopf, L.] World Org Anim Hlth, F-75017 Paris, France. [Okuthe, S.] Food & Agr Org United Nations, I-00153 Rome, Italy. [Chibeu, D.] African Union Interafrican Bur Anim Resources, Nairobi 00100, Kenya. [Parmley, J.] Vet Borders Vet Sans Frontieres Canada, Victoria, BC V8W 3R9, Canada. [Musenero, M.] African Field Epidemiol Network, Kampala, Uganda. [Pisang, C.] Vet Borders Vet Sans Frontieres Belgium, Nairobi 00100, Kenya. [Zingeser, J.] US Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Mariner, JC (reprint author), Int Livestock Res Inst, POB 30709, Nairobi 00100, Kenya. RI Pfeiffer, Dirk/C-5002-2009 OI Pfeiffer, Dirk/0000-0001-7000-0530 NR 23 TC 10 Z9 10 U1 1 U2 13 PU OFFICE INT EPIZOOTIES PI PARIS PA 12 RUE DE PRONY, 75017 PARIS, FRANCE SN 0253-1933 J9 REV SCI TECH OIE JI Rev. Sci. Tech. Off. Int. Epizoot. PD DEC PY 2011 VL 30 IS 3 BP 653 EP 659 PG 7 WC Veterinary Sciences SC Veterinary Sciences GA 894YA UT WOS:000300462200001 PM 22435179 ER PT J AU Perry, R Landon, MK Greyson, B Whitfield, C Whitfield, BH Perry, N AF Perry, Robert Landon, Mary Kay Greyson, Bruce Whitfield, Charles Whitfield, Barbara Harris Perry, Nicola TI An Initial Study of Extreme, Measurable Forms of Synchronicity SO PSYCHIATRIC ANNALS LA English DT Article C1 [Perry, Robert] Calif State Univ Fullerton, Fullerton, CA 92634 USA. [Greyson, Bruce] Univ Virginia, Div Perceptual Studies, Charlottesville, VA 22903 USA. [Whitfield, Charles] Ctr Dis Control & Prevent, Atlanta, GA USA. [Perry, Nicola] Univ Exeter, Exeter EX4 4QJ, Devon, England. RP Perry, R (reprint author), Calif State Univ Fullerton, Fullerton, CA 92634 USA. EM robert@circleofa.org OI Greyson, Bruce/0000-0002-2192-7898 NR 3 TC 0 Z9 0 U1 0 U2 1 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0048-5713 J9 PSYCHIAT ANN JI Psychiatr. Ann. PD DEC PY 2011 VL 41 IS 12 BP 577 EP 583 DI 10.3928/00485713-20111104-05 PG 7 WC Psychiatry SC Psychiatry GA 893UU UT WOS:000300382900008 ER PT J AU Yen, C Tate, JE Patel, MM Cortese, MM Lopman, B Fleming, J Lewis, K Jiang, BM Gentsch, J Steele, D Parashar, UD AF Yen, Catherine Tate, Jacqueline E. Patel, Manish M. Cortese, Margaret M. Lopman, Benjamin Fleming, Jessica Lewis, Kristen Jiang, Baoming Gentsch, Jon Steele, Duncan Parashar, Umesh D. TI Rotavirus vaccines Update on global impact and future priorities SO HUMAN VACCINES LA English DT Review DE rotavirus; gastroenteritis; vaccines; rotavirus vaccines; vaccine impact ID AGED LESS-THAN-5 YEARS; 1ST 2 YEARS; ACUTE GASTROENTERITIS; YOUNG-CHILDREN; UNITED-STATES; PROTECTIVE IMMUNITY; MALAWIAN CHILDREN; SEVERE DIARRHEA; DOUBLE-BLIND; US CHILDREN AB Early rotavirus vaccine adopter countries in the Americas, Europe, and in Australia have documented substantial declines in rotavirus disease burden following the introduction of vaccination. However, the full public health impact of rotavirus vaccines has not been realized as they have not been introduced into routine immunization programs in countries of Africa and Asia with the highest rotavirus disease morbidity and mortality burden. In this article, we review the epidemiology of rotavirus disease, the development and current status of rotavirus vaccines including newly available vaccine impact data from early-introducer countries, and future priorities for implementation and monitoring of rotavirus vaccination programs in developing countries. C1 [Yen, Catherine] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Yen, Catherine; Tate, Jacqueline E.; Patel, Manish M.; Cortese, Margaret M.; Lopman, Benjamin; Jiang, Baoming; Gentsch, Jon; Parashar, Umesh D.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Fleming, Jessica; Lewis, Kristen; Steele, Duncan] PATH, Seattle, WA USA. RP Yen, C (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM cyen@cdc.gov NR 97 TC 24 Z9 25 U1 2 U2 6 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 1554-8600 J9 HUM VACCINES JI Hum. Vaccines PD DEC PY 2011 VL 7 IS 12 BP 1282 EP 1290 DI 10.4161/hv.7.12.18321 PG 9 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA 885NA UT WOS:000299784500014 PM 22108032 ER PT J AU Kim, SA Grimm, KA May, AL Harris, DM Kimmons, J Foltz, JL AF Kim, Sonia A. Grimm, Kirsten A. May, Ashleigh L. Harris, Diane M. Kimmons, Joel Foltz, Jennifer L. TI Strategies for Pediatric Practitioners to Increase Fruit and Vegetable Consumption in Children SO PEDIATRIC CLINICS OF NORTH AMERICA LA English DT Article DE Fruit; Vegetable; Consumption; Provider strategies; Children; Diet ID DIET QUALITY; FOOD PREFERENCES; PRIMARY-CARE; NUTRITION; FAMILY; ASSOCIATIONS; ADOLESCENTS; PARENTS; IMPACT; INTERVENTION AB High intake of fruits and vegetables (FV) is associated with a decreased risk for many chronic diseases and may assist in weight management, but few children and adolescents consume the recommended amounts of FV. The pediatric practitioner can positively influence FV consumption of children through patient-level interventions (eg, counseling, connecting families to community resources), community-level interventions (eg, advocacy, community involvement), and health care facility-level interventions (eg, creating a healthy food environment in the clinical setting). This article reviews the importance of FV consumption, recommended intakes for children, and strategies by which pediatric practitioners can influence FV consumption of children. C1 [Kim, Sonia A.; Grimm, Kirsten A.; May, Ashleigh L.; Harris, Diane M.; Kimmons, Joel; Foltz, Jennifer L.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Kim, SA (reprint author), Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,MS K-25, Atlanta, GA 30341 USA. EM SKim3@cdc.gov NR 85 TC 1 Z9 1 U1 2 U2 8 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0031-3955 J9 PEDIATR CLIN N AM JI Pediatr. Clin. N. Am. PD DEC PY 2011 VL 58 IS 6 BP 1439 EP + DI 10.1016/j.pcl.2011.09.011 PG 16 WC Pediatrics SC Pediatrics GA 865LF UT WOS:000298311700009 PM 22093861 ER PT J AU Parkinson, AJ AF Parkinson, A. J. TI The International Polar Year: continuing the Arctic human health legacy SO INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH LA English DT Editorial Material C1 Ctr Dis Control & Prevent, Arct Invest Program, Anchorage, AK USA. RP Parkinson, AJ (reprint author), Ctr Dis Control & Prevent, Arct Invest Program, Anchorage, AK USA. EM ajp@CDC.GOV NR 13 TC 2 Z9 2 U1 0 U2 5 PU INT ASSOC CIRCUMPOLAR HEALTH PUBL PI OULU PA AAPISTIE1, OULU, FIN-90220, FINLAND SN 1239-9736 J9 INT J CIRCUMPOL HEAL JI Int. J. Circumpolar Health PD DEC PY 2011 VL 70 IS 5 BP 447 EP 449 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 879UD UT WOS:000299356800003 PM 22208994 ER PT J AU Chatwood, S Parkinson, A Johnson, R AF Chatwood, Susan Parkinson, Alan Johnson, Rhonda TI Circumpolar health collaborations: a description of players and a call for further dialogue SO INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH LA English DT Article C1 [Chatwood, Susan] Inst Circumpolar Hlth Res, Yellowknife, NT X1A 3X7, Canada. [Chatwood, Susan] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada. [Parkinson, Alan] Ctr Dis Control & Prevent, Arct Invest Program, Anchorage, AK USA. [Johnson, Rhonda] Univ Alaska, Dept Hlth Sci, Anchorage, AK USA. RP Chatwood, S (reprint author), Inst Circumpolar Hlth Res, POB 11050, Yellowknife, NT X1A 3X7, Canada. EM susan.chatwood@ichr.ca NR 22 TC 4 Z9 4 U1 0 U2 0 PU INT ASSOC CIRCUMPOLAR HEALTH PUBL PI OULU PA AAPISTIE1, OULU, FIN-90220, FINLAND SN 1239-9736 J9 INT J CIRCUMPOL HEAL JI Int. J. Circumpolar Health PD DEC PY 2011 VL 70 IS 5 BP 576 EP 583 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 879UD UT WOS:000299356800016 PM 22067095 ER PT J AU Bennett, C Baldwin, GT Froetscher, J AF Bennett, Cathy Baldwin, Grant T. Froetscher, Janet TI SPECIAL TOPIC: ELDERLY FALLS Preface SO JOURNAL OF SAFETY RESEARCH LA English DT Editorial Material C1 [Bennett, Cathy] Ctr Dis Control & Prevent, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, CDC, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4375 J9 J SAFETY RES JI J. Saf. Res. PD DEC PY 2011 VL 42 IS 6 BP 417 EP 417 DI 10.1016/j.jsr.2011.11.003 PG 1 WC Ergonomics; Public, Environmental & Occupational Health; Social Sciences, Interdisciplinary; Transportation SC Engineering; Public, Environmental & Occupational Health; Social Sciences - Other Topics; Transportation GA 876WQ UT WOS:000299138900002 ER PT J AU Noonan, RK Sleet, DA Stevens, JA AF Noonan, Rita K. Sleet, David A. Stevens, Judy A. TI Closing the Gap: A Research Agenda to Accelerate the Adoption and Effective Use of Proven Older Adult Fall Prevention Strategies SO JOURNAL OF SAFETY RESEARCH LA English DT Article DE fall prevention; dissemination; adoption; implementation; capacity building ID IMPLEMENTATION; PROGRAM AB Introduction: To make an impact on the public's health, evidence-based interventions must be disseminated broadly, supported by training and technical assistance, adopted widely, and implemented as designed. Many effective older adult fall prevention interventions have been identified, but too few have gained wide community acceptance and little is known about the best ways to encourage their broader use. Therefore, as in many other fields, fall prevention suffers from a wide gap between scientific discoveries and their everyday use. Method: This article articulates the key activities embedded in Step 4 of the public health model-specifically translation and dissemination to ensure widespread adoption and use-in order to illuminate critical research needs in older adult fall prevention. Conclusions: These needs, if addressed, will help close the gap between research and practice. (C) 2011 National Safety Council and Elsevier Ltd. All rights reserved. C1 [Noonan, Rita K.; Sleet, David A.; Stevens, Judy A.] Ctr Dis Control & Prevent, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA. RP Noonan, RK (reprint author), Ctr Dis Control & Prevent, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, 4770 Buford Highway NE,Mailstop F-62, Atlanta, GA 30341 USA. EM RNoonan@cdc.gov NR 25 TC 9 Z9 11 U1 0 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4375 J9 J SAFETY RES JI J. Saf. Res. PD DEC PY 2011 VL 42 IS 6 BP 427 EP 430 DI 10.1016/j.jsr.2010.12.002 PG 4 WC Ergonomics; Public, Environmental & Occupational Health; Social Sciences, Interdisciplinary; Transportation SC Engineering; Public, Environmental & Occupational Health; Social Sciences - Other Topics; Transportation GA 876WQ UT WOS:000299138900005 PM 22152260 ER PT J AU Rubenstein, LZ Vivrette, R Harker, JO Stevens, JA Kramer, BJ AF Rubenstein, Laurence Z. Vivrette, Rebecca Harker, Judith O. Stevens, Judy A. Kramer, B. Josea TI Validating an evidence-based, self-rated fall risk questionnaire (FRQ) for older adults SO JOURNAL OF SAFETY RESEARCH LA English DT Article DE Falls; Fall prevention; Geriatrics; Risk assessment ID PREVENTION; PEOPLE; EPIDEMIOLOGY; METAANALYSIS AB Background: Falls are a common, serious, and often unrecognized problem facing older adults. The objective of this study was to provide an initial clinical and statistical validation for a public health strategy of fall risk self-assessment by older adults using a Fall Risk Questionnaire (FRQ). Methods: Adults age 65+ (n = 40) were recruited at a Los Angeles Veterans Affairs (VA) medical facility and at a local assisted living facility. Participants completed the FRQ self-assessment and results were compared to a "gold standard" of a clinical evaluation of risks using the American/British Geriatrics Society guidelines to assess independent predictors of falls: history of previous falls, fear of falling, gait/balance, muscle weakness, incontinence, sensation and proprioception, depression, vision, and medications. For the comparison, we used an iterative statistical approach, weighing items based on relative risk. Results: There was strong agreement between the FRQ and clinical evaluation (kappa = .875, p < .0001). Individual item kappa values ranged from .305-832. After dropping one FRQ item (vision risk) because of inadequate agreement with the clinical evaluation (kappa = .139, p = .321), the final FRQ had good concurrent validity. Conclusions: The FRQ goes beyond existing screening tools in that it is based on both evidence and clinical acceptability and has been initially validated with clinical examination data. A larger validation with longitudinal follow-up should determine the actual strength of the FRQ in predicting future falls. (C) 2011 National Safety Council and Elsevier Ltd. All rights reserved. C1 [Rubenstein, Laurence Z.] Univ Oklahoma, Coll Med, Donald W Reynolds Dept Geriatr Med, Oklahoma City, OK 73104 USA. [Rubenstein, Laurence Z.; Vivrette, Rebecca; Harker, Judith O.] Greater Los Angeles VA Med Ctr 11E, GRECC, Sepulveda, CA 91343 USA. [Stevens, Judy A.] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA. [Rubenstein, Laurence Z.; Kramer, B. Josea] Univ Calif Los Angeles, Sch Med, Sepulveda, CA 91343 USA. [Rubenstein, Laurence Z.; Kramer, B. Josea] Greater Los Angeles VA Med Ctr, GRECC, Sepulveda, CA 91343 USA. RP Rubenstein, LZ (reprint author), Univ Oklahoma, Coll Med, Donald W Reynolds Dept Geriatr Med, 921 NE 13th St,VAMC 11 G, Oklahoma City, OK 73104 USA. EM Laurence-rubenstein@ouhsc.edu NR 26 TC 7 Z9 7 U1 2 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4375 J9 J SAFETY RES JI J. Saf. Res. PD DEC PY 2011 VL 42 IS 6 BP 493 EP 499 DI 10.1016/j.jsr.2011.08.006 PG 7 WC Ergonomics; Public, Environmental & Occupational Health; Social Sciences, Interdisciplinary; Transportation SC Engineering; Public, Environmental & Occupational Health; Social Sciences - Other Topics; Transportation GA 876WQ UT WOS:000299138900012 PM 22152267 ER PT J AU Barrera, R Amador, M MacKay, AJ AF Barrera, Roberto Amador, Manuel MacKay, Andrew J. TI Population Dynamics of Aedes aegypti and Dengue as Influenced by Weather and Human Behavior in San Juan, Puerto Rico SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID TEMPORAL DISTRIBUTION; HAEMORRHAGIC FEVER; NORTHERN THAILAND; HEMORRHAGIC-FEVER; SEPTIC TANKS; CHIANG-MAI; CULICIDAE; DIPTERA; VIRUS; CLIMATE AB Previous studies on the influence of weather on Aedes aegypti dynamics in Puerto Rico suggested that rainfall was a significant driver of immature mosquito populations and dengue incidence, but mostly in the drier areas of the island. We conducted a longitudinal study of Ae. aegypti in two neighborhoods of the metropolitan area of San Juan city, Puerto Rico where rainfall is more uniformly distributed throughout the year. We assessed the impacts of rainfall, temperature, and human activities on the temporal dynamics of adult Ae. aegypti and oviposition. Changes in adult mosquitoes were monitored with BG-Sentinel traps and oviposition activity with CDC enhanced ovitraps. Pupal surveys were conducted during the drier and wetter parts of the year in both neighborhoods to determine the contribution of humans and rains to mosquito production. Mosquito dynamics in each neighborhood was compared with dengue incidence in their respective municipalities during the study. Our results showed that: 1. Most pupae were produced in containers managed by people, which explains the prevalence of adult mosquitoes at times when rainfall was scant; 2. Water meters were documented for the first time as productive habitats for Ae. aegypti; 3. Even though Puerto Rico has a reliable supply of tap water and an active tire recycling program, water storage containers and discarded tires were important mosquito producers; 4. Peaks in mosquito density preceded maximum dengue incidence; and 5. Ae. aegypti dynamics were driven by weather and human activity and oviposition was significantly correlated with dengue incidence. C1 [Barrera, Roberto; Amador, Manuel; MacKay, Andrew J.] Ctr Dis Control & Prevent, Dengue Branch, San Juan, PR USA. RP Barrera, R (reprint author), Ctr Dis Control & Prevent, Dengue Branch, San Juan, PR USA. EM rbarrera@cdc.gov NR 55 TC 65 Z9 65 U1 3 U2 30 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1935-2727 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD DEC PY 2011 VL 5 IS 12 AR e1378 DI 10.1371/journal.pntd.0001378 PG 9 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 870KI UT WOS:000298667700007 PM 22206021 ER PT J AU Chevalier, V Rakotondrafara, T Jourdan, M Heraud, JM Andriamanivo, HR Durand, B Ravaomanana, J Rollin, PE Rakotondravao, R AF Chevalier, Veronique Rakotondrafara, Toky Jourdan, Marion Heraud, Jean Michel Andriamanivo, Harena Rasamoelina Durand, Benoit Ravaomanana, Julie Rollin, Pierre E. Rakotondravao, Rene TI An Unexpected Recurrent Transmission of Rift Valley Fever Virus in Cattle in a Temperate and Mountainous Area of Madagascar SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID GENUS PHLEBOVIRUS; SAUDI-ARABIA; KENYA; DIVERSITY; EPIDEMIOLOGY; BUNYAVIRIDAE; ANTIBODIES; EMERGENCE; MOSQUITOS; ECOLOGY AB Rift Valley fever is an acute, zoonotic viral disease of domestic ruminants, caused by a phlebovirus (Bunyaviridae family). A large outbreak occurred in Madagascar in 2008-2009. The goal of the present study was to evaluate the point prevalence of antibodies against Rift Valley Fever Virus (RVFV) in cattle in the Anjozorobe district, located in the wet and temperate highland region of Madagascar and yet heavily affected by the disease, and analyse environmental and trade factors potentially linked to RVFV transmission. A serological study was performed in 2009 in 894 bovines. For each bovine, the following variables were recorded: age, location of the night pen, minimum distance from the pen to the nearest water point and the forest, nearest water point type, and herd replacement practices. The serological data were analyzed using a generalized linear mixed model. The overall anti-RVFV IgG seroprevalence rate was 28% [CI95% 25-31]. Age was statistically linked to prevalence (p = 10(-4)), being consistent with a recurrent RVFV circulation. Distance from the night pen to the nearest water point was a protective factor (p = 5.10(-3)), which would be compatible with a substantial part of the virus transmission being carried out by nocturnal mosquito vectors. However, water point type did not influence the risk of infection: several mosquito species are probably involved. Cattle belonging to owners who purchase animals to renew the herd were significantly more likely to have seroconverted than others (p = 0.04): cattle trade may contribute to the introduction of the virus in this area. The minimum distance of the night pen to the forest was not linked to the prevalence. This is the first evidence of a recurrent transmission of RVFV in such an ecosystem that associates a wet, temperate climate, high altitude, paddy fields, and vicinity to a dense rain forest. Persistence mechanisms need to be further investigated. C1 [Chevalier, Veronique; Jourdan, Marion] Int Ctr Res Agron Dev, CIRAD, AGIRs Unit, Montpellier, France. [Rakotondrafara, Toky; Andriamanivo, Harena Rasamoelina; Ravaomanana, Julie; Rakotondravao, Rene] FOFIFA DRZV, Antananarivo, Madagascar. [Heraud, Jean Michel] Inst Pasteur Madagascar, Virol Unit, Antananarivo, Madagascar. [Durand, Benoit] Agence Natl Securite Sanit ANSES, Lab Sante Anim, Maisons Alfort, France. [Rollin, Pierre E.] Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA USA. RP Chevalier, V (reprint author), Int Ctr Res Agron Dev, CIRAD, AGIRs Unit, Montpellier, France. EM chevalier@cirad.fr RI HERAUD, Jean-Michel/O-1464-2013; OI HERAUD, Jean-Michel/0000-0003-1107-0859; Durand, Benoit/0000-0003-0669-1394 FU CRVOI (Centre de Recherche et de Veille sur les maladies emergentes dans l'Ocean Indien) FX This work was funded by CRVOI (Centre de Recherche et de Veille sur les maladies emergentes dans l'Ocean Indien). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 46 TC 21 Z9 21 U1 0 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1935-2727 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD DEC PY 2011 VL 5 IS 12 AR e1423 DI 10.1371/journal.pntd.0001423 PG 6 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 870KI UT WOS:000298667700028 PM 22206026 ER PT J AU Gregory, CJ Lorenzi, OD Colon, L Garcia, AS Santiago, LM Rivera, RC Bermudez, LJC Baez, FO Aponte, DV Tomashek, KM Gutierrez, J Alvarado, L AF Gregory, Christopher J. Lorenzi, Olga D. Colon, Lisandra Garcia, Arleene Sepulveda Santiago, Luis M. Rivera, Ramon Cruz Cuyar Bermudez, Liv Jossette Baez, Fernando Ortiz Aponte, Delanor Vazquez Tomashek, Kay M. Gutierrez, Jorge Alvarado, Luisa TI Utility of the Tourniquet Test and the White Blood Cell Count to Differentiate Dengue among Acute Febrile Illnesses in the Emergency Room SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID CLINICAL-MANIFESTATIONS; PUERTO-RICO; LABORATORY INDICATORS; HEMORRHAGIC-FEVER; VIRUS-INFECTION; DIAGNOSIS; SEROTYPE; ADULTS; IDENTIFICATION; CHILDREN AB Dengue often presents with non-specific clinical signs, and given the current paucity of accurate, rapid diagnostic laboratory tests, identifying easily obtainable bedside markers of dengue remains a priority. Previous studies in febrile Asian children have suggested that the combination of a positive tourniquet test (TT) and leucopenia can distinguish dengue from other febrile illnesses, but little data exists on the usefulness of these tests in adults or in the Americas. We evaluated the diagnostic accuracy of the TT and leucopenia (white blood cell count <5000/mm(3)) in identifying dengue as part of an acute febrile illness (AFI) surveillance study conducted in the Emergency Department of Saint Luke's Hospital in Ponce, Puerto Rico. From September to December 2009, 284 patients presenting to the ED with fever for 2-7 days and no identified source were enrolled. Participants were tested for influenza, dengue, leptospirosis and enteroviruses. Thirty-three (12%) patients were confirmed as having dengue; 2 had dengue co-infection with influenza and leptospirosis, respectively. An infectious etiology was determined for 141 others (136 influenza, 3 enterovirus, 2 urinary tract infections), and 110 patients had no infectious etiology identified. Fifty-two percent of laboratory-positive dengue cases had a positive TT versus 18% of patients without dengue (P<0.001), 87% of dengue cases compared to 28% of non-dengue cases had leucopenia (P<0.001). The presence of either a positive TT or leucopenia correctly identified 94% of dengue patients. The specificity and positive predictive values of these tests was significantly higher in the subset of patients without pandemic influenza A H1N1, suggesting improved discriminatory performance of these tests in the absence of concurrent dengue and influenza outbreaks. However, even during simultaneous AFI outbreaks, the absence of leucopenia combined with a negative tourniquet test may be useful to rule out dengue. C1 [Gregory, Christopher J.; Lorenzi, Olga D.; Santiago, Luis M.; Tomashek, Kay M.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Dengue Branch, San Juan, PR USA. [Colon, Lisandra; Garcia, Arleene Sepulveda; Rivera, Ramon Cruz; Cuyar Bermudez, Liv Jossette; Baez, Fernando Ortiz; Aponte, Delanor Vazquez; Gutierrez, Jorge; Alvarado, Luisa] Ponce Univ, Sch Med, Ponce, PR USA. RP Gregory, CJ (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, Dengue Branch, San Juan, PR USA. EM hgk4@cdc.gov FU Centers for Disease Control and Prevention (CDC) FX This study was funded by the Centers for Disease Control and Prevention (CDC). CDC scientists participated in the study design, data collection and analysis, decision to publish, and preparation of the manuscript. NR 34 TC 15 Z9 15 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1935-2727 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD DEC PY 2011 VL 5 IS 12 AR e1400 DI 10.1371/journal.pntd.0001400 PG 6 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 870KI UT WOS:000298667700011 PM 22163057 ER PT J AU Dudeck, MA Horan, TC Peterson, KD Allen-Bridson, K Morrell, G Pollock, DA Edwards, JR AF Dudeck, Margaret A. Horan, Teresa C. Peterson, Kelly D. Allen-Bridson, Katherine Morrell, Gloria Pollock, Daniel A. Edwards, Jonathan R. TI National Healthcare Safety Network (NHSN) Report, data summary for 2010, device-associated module SO AMERICAN JOURNAL OF INFECTION CONTROL LA English DT Article C1 [Dudeck, Margaret A.; Horan, Teresa C.; Peterson, Kelly D.; Allen-Bridson, Katherine; Morrell, Gloria; Pollock, Daniel A.; Edwards, Jonathan R.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Natl Ctr Emerging Zoonot & Infect Dis, Publ Hlth Serv,US Dept Hlth & Human Serv, Atlanta, GA 30329 USA. RP Dudeck, MA (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Natl Ctr Emerging Zoonot & Infect Dis, Publ Hlth Serv,US Dept Hlth & Human Serv, Atlanta, GA 30329 USA. EM mdudeck@cdc.gov NR 10 TC 140 Z9 153 U1 0 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-6553 J9 AM J INFECT CONTROL JI Am. J. Infect. Control PD DEC PY 2011 VL 39 IS 10 BP 798 EP 816 DI 10.1016/j.ajic.2011.10.001 PG 19 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 863BF UT WOS:000298137100003 PM 22133532 ER PT J AU Hossain, MJ Bourgeois, M Quan, FS Lipatov, AS Song, JM Chen, LM Compans, RW York, I Kang, SM Donis, RO AF Hossain, M. Jaber Bourgeois, Melissa Quan, Fu-Shi Lipatov, Aleksandr S. Song, Jae-Min Chen, Li-Mei Compans, Richard W. York, Ian Kang, Sang-Moo Donis, Ruben O. TI Virus-Like Particle Vaccine Containing Hemagglutinin Confers Protection against 2009 H1N1 Pandemic Influenza SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID CORONAVIRUS-LIKE PARTICLES; CELLULAR IMMUNE-RESPONSES; SINGLE-DOSE VACCINATION; SEASONAL INFLUENZA; AVIAN INFLUENZA; VLP VACCINE; A H1N1; HETEROSUBTYPIC IMMUNITY; HETEROLOGOUS STRAINS; EXPRESSION SYSTEM AB Immunization of the world population before an influenza pandemic such as the 2009 H1N1 virus spreads globally is not possible with current vaccine production platforms. New influenza vaccine technologies, such as virus-like-particles (VLPs), offer a promising alternative. Here, we tested the immunogenicity and protective efficacy of a VLP vaccine containing hemagglutinin (HA) and M1 from the 2009 pandemic H1N1 influenza virus (H1N1pdm) in ferrets and compared intramuscular (i.m.) and intranasal (i.n.) routes of immunization. Vaccination of ferrets with VLPs containing the M1 and HA proteins from A/California/04/2009 (H1N1pdm) induced high antibody titers and conferred significant protection against virus challenge. VLP-vaccinated animals lost less weight, shed less virus in nasal washes, and had markedly lower virus titers in all organs tested than naive controls. A single dose of VLPs, either i.m. or i.n., induced higher levels of antibody than did two doses of commercial split vaccine. Ferrets vaccinated with split vaccine were incompletely protected against challenge; these animals had lower virus titers in olfactory bulbs, tonsils, and intestines, but lost weight and shed virus in nasal washes to a similar extent as naive controls. Challenge with heterologous A/Brisbane/59/07 (H1N1) virus revealed that the VLPs conferred minimal cross-protection to heterologous infection, as revealed by the lack of reduction in nasal wash and lung virus titers and slightly higher weight loss relative to controls. In summary, these experiments demonstrate the strong immunogenicity and protective efficacy of VLPs compared to the split vaccine and show that i.n. vaccination with VLPs has the potential for highly efficacious vaccination against influenza. C1 [Hossain, M. Jaber; Bourgeois, Melissa; Lipatov, Aleksandr S.; Chen, Li-Mei; York, Ian; Donis, Ruben O.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA. [Quan, Fu-Shi; Song, Jae-Min; Compans, Richard W.; Kang, Sang-Moo] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA. [Hossain, M. Jaber] Battelle Mem Inst, Atlanta, GA 30333 USA. [Song, Jae-Min; Kang, Sang-Moo] Georgia State Univ, Dept Biol, Ctr Inflammat Immun & Infect, Atlanta, GA 30303 USA. RP Donis, RO (reprint author), Ctr Dis Control & Prevent, Influenza Div, Mailstop G-16,1600 Clifton Rd, Atlanta, GA 30333 USA. EM rvd6@cdc.gov RI Compans, Richard/I-4087-2013; OI Compans, Richard/0000-0003-2360-335X; York, Ian/0000-0002-3478-3344 FU NIH/NIAID [AI0680003, AI074579]; Centers for Disease Control and Prevention FX This work was supported in part by NIH/NIAID grants AI0680003 (R. W. C.) and AI074579 (R. W. C.). This research was supported in part by an appointment to the Research Participation Program at the Centers for Disease Control and Prevention administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and CDC. NR 53 TC 14 Z9 14 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD DEC PY 2011 VL 18 IS 12 BP 2010 EP 2017 DI 10.1128/CVI.05206-11 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 863CX UT WOS:000298141500001 PM 22030367 ER PT J AU Thomas, JD Jackson, ML Sharma, D Mair, R Bach, MC Castillo, D Ejigiri, OG Satola, S Cohn, AC Jerris, R Jain, S Farley, MM Mayer, LW Messonnier, NE AF Thomas, Jennifer Dolan Jackson, Michael L. Sharma, Dolly Mair, Raydel Bach, Michelle C. Castillo, Dana Ejigiri, O. Grace Satola, Sarah Cohn, Amanda C. Jerris, Robert Jain, Shabnam Farley, Monica M. Mayer, Leonard W. Messonnier, Nancy E. TI Haemophilus influenzae Type b Carriage among Young Children in Metropolitan Atlanta in the Context of Vaccine Shortage and Booster Dose Deferral SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article AB Short-term deferral of the Haemophilus influenzae type b (Hib) vaccine booster dose during a recent U. S. Hib vaccine shortage did not result in widespread Hib carriage in Atlanta, as the Hib carriage rate was found to be 0.3% (1/342). Hib colonization was significantly more common among males and day care attendees. C1 [Thomas, Jennifer Dolan; Jackson, Michael L.; Mair, Raydel; Bach, Michelle C.; Castillo, Dana; Ejigiri, O. Grace; Cohn, Amanda C.; Mayer, Leonard W.; Messonnier, Nancy E.] Ctr Dis Control & Prevent, Meningitis & Vaccine Preventable Dis Branch, Div Bacterial Dis, Natl Ctr Immunizat Resp Dis, Atlanta, GA 30329 USA. [Sharma, Dolly; Satola, Sarah; Jerris, Robert; Jain, Shabnam; Farley, Monica M.] Emory Univ, Sch Med, Atlanta, GA 30322 USA. [Sharma, Dolly; Jerris, Robert; Jain, Shabnam] Childrens Healthcare Atlanta, Atlanta, GA 30322 USA. [Satola, Sarah; Farley, Monica M.] Vet Affairs Med Ctr, Decatur, GA 30033 USA. [Satola, Sarah; Farley, Monica M.] Atlanta VA Med Ctr, Georgia Emerging Infect Program, Decatur, GA 30033 USA. [Bach, Michelle C.] Agnes Scott Coll, Dept Biol, Decatur, GA 30030 USA. RP Thomas, JD (reprint author), CDC, 1600 Clifton Rd,NE,MS D-11, Atlanta, GA 30333 USA. EM fsu8@cdc.gov FU Georgia Emerging Infections Program; Children's Healthcare of Atlanta FX We thank the Georgia Emerging Infections Program and the Children's Healthcare of Atlanta Friend's Research Fund for partial financial support of this study. NR 13 TC 2 Z9 2 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD DEC PY 2011 VL 18 IS 12 BP 2178 EP 2180 DI 10.1128/CVI.05254-11 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 863CX UT WOS:000298141500025 PM 22012977 ER PT J AU Thibodeaux, BA Liss, NM Panella, AN Roehrig, JT AF Thibodeaux, Brett A. Liss, Nathan M. Panella, Amanda N. Roehrig, John T. TI Development of a Human-Murine Chimeric Immunoglobulin M for Use in the Serological Detection of Human Alphavirus Antibodies SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID HUMAN FLAVIVIRUS AB Diagnosis of human alphaviral infections relies on serological techniques, such as the immunoglobulin M antibody capture-enzyme-linked immunosorbent assay (MAC-ELISA). We have humanized the alphavirus broadly cross-reactive murine monoclonal antibody 1A4B-6 to create a reagent capable of replacing human positive sera in the MAC-ELISA for diagnosis of human alphaviral infections. C1 [Thibodeaux, Brett A.; Liss, Nathan M.; Panella, Amanda N.; Roehrig, John T.] Ctr Dis Control & Prevent, Arboviral Dis Branch, Div Vector Borne Dis,US Dept Hlth & Human Serv, Natl Ctr Emerging & Zoonot Infect Dis,Coordinatin, Ft Collins, CO 80521 USA. RP Thibodeaux, BA (reprint author), CDC, Div Vector Borne Dis, Natl Ctr Emerging & Zoonot Infect Dis, 3150 Ramp Rd, Ft Collins, CO 80521 USA. EM epx1@cdc.gov; jtr1@cdc.gov OI Roehrig, John/0000-0001-7581-0479 FU American Society for Microbiology; Coordinating Center for Infectious Diseases FX This work was supported, in part, by a postdoctoral fellowship awarded to B. A. T. by the American Society for Microbiology and the Coordinating Center for Infectious Diseases. NR 5 TC 2 Z9 2 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD DEC PY 2011 VL 18 IS 12 BP 2181 EP 2182 DI 10.1128/CVI.05269-11 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 863CX UT WOS:000298141500026 PM 21976225 ER PT J AU Jaeger, JL Patel, M Dharan, N Hancock, K Meites, E Mattson, C Gladden, M Sugerman, D Doshi, S Blau, D Harriman, K Whaley, M Sun, H Ginsberg, M Kao, AS Kriner, P Lindstrom, S Jain, S Katz, J Finelli, L Olsen, SJ Kallen, AJ AF Jaeger, Jenifer L. Patel, Minal Dharan, Nila Hancock, Kathy Meites, Elissa Mattson, Christine Gladden, Matt Sugerman, David Doshi, Saumil Blau, Dianna Harriman, Kathleen Whaley, Melissa Sun, Hong Ginsberg, Michele Kao, Annie S. Kriner, Paula Lindstrom, Stephen Jain, Seema Katz, Jacqueline Finelli, Lyn Olsen, Sonja J. Kallen, Alexander J. TI Transmission of 2009 Pandemic Influenza A (H1N1) Virus among Healthcare Personnel-Southern California, 2009 SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID INFECTION-CONTROL MEASURES; UNITED-STATES; RANDOMIZED-TRIAL; EMERGENCY-DEPARTMENT; HAND HYGIENE; WORKERS; POPULATIONS; ILLNESS; MASK; SARS AB OBJECTIVE. In April 2009, 2009 pandemic influenza A (H1N1) (hereafter, pH1N1) virus was identified in California, which caused widespread illness throughout the United States. We evaluated pH1N1 transmission among exposed healthcare personnel (HCP) and assessed the use and effectiveness of personal protective equipment (PPE) early in the outbreak. DESIGN. Cohort study. SETTING. Two hospitals and 1 outpatient clinic in Southern California during March 28-April 24, 2009. PARTICIPANTS. Sixty-three HCP exposed to 6 of the first 8 cases of laboratory-confirmed pH1N1 in the United States. METHODS. Baseline and follow-up questionnaires were used to collect demographic, epidemiologic, and clinical data. Paired serum samples were obtained to test for pH1N1-specific antibodies by microneutralization and hemagglutination-inhibition assays. Serology results were compared with HCP work setting, role, and self-reported PPE use. RESULTS. Possible healthcare-associated pH1N1 transmission was identified in 9 (14%) of 63 exposed HCP; 6 (67%) of 9 seropositive HCP had asymptomatic infection. The highest attack rates occurred among outpatient HCP (6/19 [32%]) and among allied health staff (eg, technicians; 8/33 [24%]). Use of mask or N95 respirator was associated with remaining seronegative (P = 047). Adherence to PPE recommendations for preventing transmission of influenza virus and other respiratory pathogens was inadequate, particularly in outpatient settings. CONCLUSIONS. pH1N1 transmission likely occurred in healthcare settings early in the pandemic associated with inadequate PPE use. Organizational support for a comprehensive approach to infectious hazards, including infection prevention training for inpatient-and outpatient-based HCP, is essential to improve HCP and patient safety. Infect Control Hosp Epidemiol 2011; 32(12): 1149-1157 C1 [Jaeger, Jenifer L.; Patel, Minal; Dharan, Nila; Meites, Elissa; Mattson, Christine; Gladden, Matt; Sugerman, David; Doshi, Saumil; Blau, Dianna] Ctr Dis Control & Prevent CDC, Epidem Intelligence Serv, Atlanta, GA USA. [Patel, Minal; Meites, Elissa; Blau, Dianna; Kallen, Alexander J.] CDC, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Dharan, Nila; Hancock, Kathy; Sugerman, David; Doshi, Saumil; Whaley, Melissa; Sun, Hong; Lindstrom, Stephen; Jain, Seema; Katz, Jacqueline; Finelli, Lyn; Olsen, Sonja J.] CDC, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Mattson, Christine] CDC, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Gladden, Matt] CDC, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA. [Harriman, Kathleen] Calif Dept Publ Hlth, Sacramento, CA USA. [Ginsberg, Michele; Kao, Annie S.] San Diego Cty Hlth & Human Serv Agcy, San Diego, CA USA. [Kriner, Paula] Imperial Cty Publ Hlth Dept, El Centro, CA USA. RP Kallen, AJ (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, 1600 Clifton Rd NE,MS A-35, Atlanta, GA 30333 USA. EM akallen@cdc.gov OI Meites, Elissa/0000-0002-0077-2591 NR 46 TC 14 Z9 14 U1 0 U2 5 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD DEC PY 2011 VL 32 IS 12 BP 1149 EP 1157 DI 10.1086/662709 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 876CH UT WOS:000299084200001 PM 22080652 ER PT J AU Tosh, PK Disbot, M Duffy, JM Boom, ML Heseltine, G Srinivasan, A Gould, CV Berrios-Torres, SI AF Tosh, Pritish K. Disbot, Maureen Duffy, Jonathan M. Boom, Marc L. Heseltine, Gary Srinivasan, Arjun Gould, Carolyn V. Berrios-Torres, Sandra I. TI Outbreak of Pseudomonas aeruginosa Surgical Site Infections after Arthroscopic Procedures: Texas, 2009 SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID CRUCIATE LIGAMENT RECONSTRUCTION; SEPTIC ARTHRITIS; SURGERY AB SETTING. Seven organ/space surgical site infections (SSIs) that occurred after arthroscopic procedures and were due to Pseudomonas aeruginosa of indistinguishable pulsed-field gel electrophoresis (PFGE) patterns occurred at hospital X in Texas from April 22, 2009, through May 7, 2009. OBJECTIVE. To determine the source of the outbreak and prevent future infections. DESIGN. Infection control observations and a case-control study. METHODS. Laboratory records were reviewed for case finding. A case-control study was conducted. A case patient was defined as someone who underwent knee or shoulder arthroscopy at hospital X during the outbreak period and subsequently developed organ/space SSI due to P. aeruginosa. Cultures of environmental and surgical equipment samples were performed, and selected isolates were analyzed by PFGE. Surgical instrument reprocessing practices were reviewed, and surgical instrument lumens were inspected with a borescope after reprocessing to assess cleanliness. RESULTS. The case-control study did not identify any significant patient-related or operator-related risk factors. P. aeruginosa grew from 62 of 388 environmental samples. An isolate from the gross decontamination sink had a PFGE pattern that was indistinguishable from that of the case patient isolates. All surgical instrument cultures showed no growth. Endoscopic evaluation of reprocessed arthroscopic equipment revealed retained tissue in the lumen of both the inflow/outflow cannulae and arthroscopic shaver handpiece. No additional cases occurred after changes in instrument reprocessing protocols were implemented. After this outbreak, the US Food and Drug Administration released a safety alert about the concern regarding retained tissue within arthroscopic shavers. CONCLUSIONS. These SSIs were likely related to surgical instrument contamination with P. aeruginosa during instrument reprocessing. Retained tissue in inflow/outflow cannulae and shaver handpieces could have allowed bacteria to survive sterilization procedures. Infect Control Hosp Epidemiol 2011; 32(12): 1179-1186 C1 [Tosh, Pritish K.; Duffy, Jonathan M.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. [Tosh, Pritish K.; Duffy, Jonathan M.; Srinivasan, Arjun; Gould, Carolyn V.; Berrios-Torres, Sandra I.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. [Disbot, Maureen; Boom, Marc L.] Methodist Hosp, Houston, TX 77030 USA. [Heseltine, Gary] Texas Dept State Hlth Serv, Austin, TX USA. RP Tosh, PK (reprint author), Mayo Clin, Div Infect Dis, 200 1st St SW, Rochester, MN 55905 USA. EM tosh.pritish@mayo.edu NR 15 TC 25 Z9 26 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD DEC PY 2011 VL 32 IS 12 BP 1179 EP 1186 DI 10.1086/662712 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 876CH UT WOS:000299084200005 PM 22080656 ER PT J AU Miller, BL Ahmed, F Lindley, MC Wortley, PM AF Miller, Brady L. Ahmed, Faruque Lindley, Megan C. Wortley, Pascale M. TI US Hospital Requirements for Pertussis Vaccination of Healthcare Personnel, 2011 SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID OUTBREAKS; TETANUS; ADULTS AB In 2011, institutional requirements for pertussis vaccination of healthcare personnel were reported by nearly one-third of surveyed US hospitals. Requirements often applied to personnel with certain clinical responsibilities, such as those caring for infants. Healthcare personnel who were not on an institution's payroll were rarely subject to pertussis vaccination requirements. Infect Control Hosp Epidemiol 2011; 32(12): 1209-1212 C1 [Miller, Brady L.; Ahmed, Faruque; Lindley, Megan C.; Wortley, Pascale M.] Ctr Dis Control & Prevent, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Miller, BL (reprint author), Ctr Dis Control & Prevent, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd,MS E-52, Atlanta, GA 30333 USA. EM ion2@cdc.gov NR 10 TC 4 Z9 4 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD DEC PY 2011 VL 32 IS 12 BP 1209 EP 1212 DI 10.1086/662711 PG 4 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 876CH UT WOS:000299084200009 PM 22080660 ER PT J AU El Bour, M Dellall, M Boukef, I Lakhal, F Mraouna, R El Hili, HA Paillard, C Klena, J AF El Bour, Monia Dellall, Mohamed Boukef, Imene Lakhal, Fatma Mraouna, Radhia El Hili, Hedia Attia Paillard, Christine Klena, John TI OCCURRENCE OF BROWN RING DISEASE IN CARPET SHELL CLAMS RUDITAPES DECUSSATUS FROM THE GULF OF GABES (TUNISIA, CENTRAL MEDITERRANEAN SEA) SO JOURNAL OF SHELLFISH RESEARCH LA English DT Article DE shell disease; clams; Ruditapes; prevalence; Vibrio spp.; temperature ID MANILA CLAM; VIBRIO-TAPETIS; CRASSOSTREA-VIRGINICA; HALIOTIS-TUBERCULATA; EASTERN OYSTER; PHILIPPINARUM; PERKINSOSIS; PARAMETERS; MOLLUSKS AB The occurrence and spread of brown ring disease (BRD) to several northern Mediterranean coasts is described. We report the results of a 6-y surveillance of BRD in natural populations of carpet shell clams (Ruditapes decussatus) in 14 zones along the Gulf of Gabes in Tunisia (southern Mediterranean Sea). BRD symptoms in adult animals resulting from conchiolin deposits in inner parts of carpet shell were observed in all zones surveyed. Infestation rates within each site ranged from 65-100%, and BRD prevalence varied from 1-58% of clams in winter and from 1-33% in summer. Positive correlations were demonstrated between BRD prevalence and Vibrio spp. concentrations in clams. Vibrio tapetis was not identified among the bacterial organisms, suggesting that other marine Vibrio species are capable of causing BRD-like illness in carpet shell clams. C1 [El Bour, Monia; Boukef, Imene; Mraouna, Radhia; El Hili, Hedia Attia] Inst Natl Sci & Technol Mer INSTM, Lab Pathol Organismes Aquat, Salammbo 2025, Tunisia. [Dellall, Mohamed] FSB, Lab Ecol & Biosurveillance Cotiere, Zarzouna, Tunisia. [Paillard, Christine] Univ Bretagne Occidentale, CNRS, Inst Europeen Mer, Lab Sci Environm Marin,LEMAR,UMR 6539, F-29280 Plouzane, France. [Klena, John] US Ctr Dis Control & Prevent, Atlanta, GA USA. RP El Bour, M (reprint author), Inst Natl Sci & Technol Mer INSTM, Lab Pathol Organismes Aquat, Rue 2 Mars 1934, Salammbo 2025, Tunisia. EM monia.elbour@instm.rnrt.tn OI Mohamed, DELLALI/0000-0002-4979-3369 FU INSTM/IFREMER-IUEM FX This work was supported by an INSTM/IFREMER-IUEM joint program on the health assessment of epizootic infections in Tunisian populations of bivalves. We thank the Ministry of Agriculture (Tunis) for providing good conditions during samples preparation. We also thank Dr. Fetid Sellem from the INSTM for her technical support. NR 41 TC 0 Z9 0 U1 0 U2 7 PU NATL SHELLFISHERIES ASSOC PI GROTON PA C/O DR. SANDRA E. SHUMWAY, UNIV CONNECTICUT, 1080 SHENNECOSSETT RD, GROTON, CT 06340 USA SN 0730-8000 J9 J SHELLFISH RES JI J. Shellfish Res. PD DEC PY 2011 VL 30 IS 3 BP 797 EP 804 DI 10.2983/035.030.0320 PG 8 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 876WO UT WOS:000299138700020 ER PT J AU Tharp, AT Burton, T Freire, K Hall, DM Harrier, S Latzman, NE Luo, FJ Niolon, PH Ramirez, M Vagi, KJ AF Tharp, Andra Teten Burton, Tessa Freire, Kimberley Hall, Diane M. Harrier, Sara Latzman, Natasha E. Luo, Feijun Niolon, Phyllis Holditch Ramirez, Mia Vagi, Kevin J. TI Dating Matters (TM): Strategies to Promote Healthy Teen Relationships SO JOURNAL OF WOMENS HEALTH LA English DT Article ID VIOLENCE PREVENTION; PROGRAM; IMPLEMENTATION AB Teen dating violence (TDV) is a preventable public health problem that has negative consequences for youth. Despite evidence that youth in urban communities with high crime and economic disadvantage may be at particularly high risk for TDV, little work has specifically addressed TDV in these communities. The Centers for Disease Control and Prevention (CDC) has developed a comprehensive approach to prevent TDV-Dating Matters (TM): Strategies to Promote Healthy Teen Relationships-that addresses gaps in research and practice. This Report from CDC describes the programmatic activities, implementation support, evaluation, and surveillance of the Dating Matters (TM) initiative, which will be implemented in four urban communities. C1 [Tharp, Andra Teten] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Div Violence Prevent, Atlanta, GA 30341 USA. RP Tharp, AT (reprint author), Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Div Violence Prevent, 4770 Buford Highway,MS F-64, Atlanta, GA 30341 USA. EM atharp@cdc.gov FU CDC; U.S. Department of Energy FX The work of N.E.L. on this project was supported in part through the Research Participation Program at the CDC, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and CDC. NR 17 TC 20 Z9 20 U1 0 U2 15 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 J9 J WOMENS HEALTH JI J. Womens Health PD DEC PY 2011 VL 20 IS 12 BP 1761 EP 1765 DI 10.1089/jwh.2011.3177 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA 863IJ UT WOS:000298155700001 PM 22017356 ER PT J AU Cox, S Dean, T Posner, SF Jamieson, DJ Curtis, KM Johnson, CH Meikle, S AF Cox, Shanna Dean, Teresa Posner, Samuel F. Jamieson, Denise J. Curtis, Kathryn M. Johnson, Christopher H. Meikle, Susan TI Disparities in Reproductive Health-Related Visits to the Emergency Department in Maryland by Age and Race, 1999-2005 SO JOURNAL OF WOMENS HEALTH LA English DT Article ID SEXUALLY-TRANSMITTED INFECTIONS; MEDICAL-CARE SURVEY; QUALITY-OF-CARE; UNITED-STATES; INSURANCE STATUS; GYNECOLOGIC DISORDERS; COSTS; ADOLESCENTS; MANAGEMENT; ILLNESSES AB Objective: To describe reproductive health-related visits to Maryland emergency departments (EDs) among women aged 15-44 years from 1999 to 2005. Methods: We obtained data from the Healthcare Cost and Utilization Project State Emergency Department Database and State Inpatient Database. ICD-9-CM diagnosis codes were used to classify reproductive health-related visits. We calculated the annual rate of reproductive health visits to Maryland EDs from 1999 to 2005 for women aged 15-44 years and tested time trends using linear regression. Admission rates were defined as the percentage of ED visits that resulted in inpatient admission. We calculated age-specific and race-specific rate ratios for diagnoses using Poisson regression and admission rate ratios using Cochran-Mantel-Haenszel statistics. Results: From 1999 to 2005, the rate of ED visits in Maryland increased 50%, from 28.0 to 42.1 visits per 1000 women. Lower genital tract infections were the most common diagnosis (21.4%). The rates were higher for women aged 15-24 than for women aged 25-44 (rate ratio 1.18, 95% confidence interval [CI] 1.17-1.18) and nearly three times higher for black women than white women (rate ratio 2.94, 95% CI 2.92-2.96). Admission rates were lower for women aged 15-24 than for women aged 25-44 (rate ratio 0.34, 95% CI 0.33-0.35) and were higher among black than white women (rate ratio 1.16, 95% CI 1.14-1.18). Conclusions: Disparities by age and race are evident for reproductive health-related ED visits in Maryland, and many of these ED visits are for conditions that are amenable to preventive measures. C1 [Cox, Shanna; Dean, Teresa; Posner, Samuel F.; Jamieson, Denise J.; Curtis, Kathryn M.; Johnson, Christopher H.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Meikle, Susan] Eunice K Shriver Natl Inst Child Hlth & Human Dev, Contracept & Reprod Hlth Branch, NIH, Bethesda, MD USA. RP Cox, S (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway,MS K-20, Atlanta, GA 30341 USA. EM cio8@cdc.gov NR 51 TC 3 Z9 3 U1 0 U2 6 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 J9 J WOMENS HEALTH JI J. Womens Health PD DEC PY 2011 VL 20 IS 12 BP 1833 EP 1838 DI 10.1089/jwh.2010.2554 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA 863IJ UT WOS:000298155700011 PM 22074208 ER PT J AU Watson-Johnson, LC DeGroff, A Steele, CB Revels, M Smith, JL Justen, E Barron-Simpson, R Sanders, L Richardson, LC AF Watson-Johnson, Lisa C. DeGroff, Amy Steele, C. Brooke Revels, Michelle Smith, Judith Lee Justen, Erin Barron-Simpson, Rachel Sanders, Latasha Richardson, Lisa C. TI Mammography Adherence: A Qualitative Study SO JOURNAL OF WOMENS HEALTH LA English DT Article ID BREAST-CANCER; SCREENING MAMMOGRAPHY; WOMEN; POPULATION; BENEFITS; HARMS; INTERVENTION; COVERAGE; ISSUE AB Background: Regular mammography accounts for half of the recent declines in breast cancer mortality. Mammography use declined significantly in 2008. Given the success of regular breast cancer screening, understanding why mammography use decreased is important. We undertook a focus group study to explore reasons women who were previously adherent with regular mammography no longer were screened. Methods: We conducted 20 focus groups with white non-Hispanic, black non-Hispanic, Hispanic, Japanese American, and American Indian/Alaska Native women, and segmented the groups by age, race/ethnicity, and health insurance status. A conceptual framework, based on existing research, informed the development of the focus group guide. Discussion topics included previous mammography experiences, perceptions of personal breast cancer risk, barriers to mammography, and risks and benefits associated with undergoing mammography. Atlas.ti was used to facilitate data analysis. Results: All focus groups (n = 128 women) were completed in 2009 in five cities across the United States. Half of the groups were held with white non-Hispanic women and the remainder with other racial/ethnic groups. Major barriers to routine mammography included (1) concerns about test efficacy, (2) personal concerns about the procedure, (3) access to screening services, (4) psychosocial issues, and (5) cultural factors. For uninsured women, lack of health insurance was the primary barrier to mammography. Conclusions: Multilevel interventions at the health-care provider and system levels are needed to address barriers women experience to undergoing regular mammography screening. Ultimately, breast cancer screening with mammography is an individual behavior; therefore, individual behavioral change strategies will continue to be needed. C1 [Watson-Johnson, Lisa C.; DeGroff, Amy; Steele, C. Brooke; Smith, Judith Lee; Sanders, Latasha; Richardson, Lisa C.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Revels, Michelle] ICF Macro, Atlanta, GA USA. [Justen, Erin] CDC Fdn, Atlanta, GA USA. [Barron-Simpson, Rachel] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Watson-Johnson, LC (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,Mail Stop K-55, Atlanta, GA 30341 USA. EM lfr8@cdc.gov FU Susan G. Komen for the Cure FX This study is supported by a grant to the CDC Foundation from Susan G. Komen for the Cure. We thank Susan G. Komen for the Cure for funding the study, CDC Foundation for providing technical assistance, Komen affiliates for contributing to the recruitment effort, and all the participants for sharing their experiences and thoughts. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 44 TC 19 Z9 19 U1 2 U2 13 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 J9 J WOMENS HEALTH JI J. Womens Health PD DEC PY 2011 VL 20 IS 12 BP 1887 EP 1894 DI 10.1089/jwh.2010.2724 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA 863IJ UT WOS:000298155700019 PM 22023414 ER PT J AU Desai, R de Oliveira, LH Parashar, UD Lopman, B Tate, JE Patel, MM AF Desai, Rishi de Oliveira, Lucia Helena Parashar, Umesh D. Lopman, Benjamin Tate, Jacqueline E. Patel, Manish M. TI Reduction in morbidity and mortality from childhood diarrhoeal disease after species A rotavirus vaccine introduction in Latin America - A Review SO MEMORIAS DO INSTITUTO OSWALDO CRUZ LA English DT Review DE species A rotavirus; rotavirus; vaccines; Latin America ID LESS-THAN-5 YEARS; CHILDREN; MEXICO; BRAZIL; HOSPITALIZATIONS; GASTROENTERITIS; PROTECTION; EFFICACY; SAFETY; AGE AB Countries in Latin America were among the first to implement routine vaccination against species A rotavirus (RVA). We evaluate data from Latin America on reductions in gastroenteritis and RVA disease burden following the introduction of RVA vaccine. Published literature was reviewed to identify case-control studies of vaccine effectiveness and population-based studies examining longitudinal trends of diarrhoeal disease reduction after RVA vaccine introduction in Latin American countries. RVA vaccine effectiveness and impact on gastroenteritis mortality and hospitalization rates and RVA hospitalization rates are described. Among middle-income Latin American countries with published data (Mexico, Brazil, El Salvador and Panama), RVA vaccine contributed to a gastroenteritis-associated mortality reduction of 22-41%, a gastroenteritis-associated hospitalization reduction of 17-51% and a RVA hospitalization reduction of 59-81% among children younger than five years of age. In Brazil and El Salvador, case-control studies demonstrated that a full RVA vaccination schedule was 76-85% effective against RVA hospitalization; a lower effectiveness of 46% was seen in Nicaragua, the only low-income country with available data. A growing body of literature offers convincing evidence of "real world" vaccine program successes in Latin American settings, which may be expanded as more countries in the region include RVA vaccine in their immunization programs. C1 [Desai, Rishi; Parashar, Umesh D.; Lopman, Benjamin; Tate, Jacqueline E.; Patel, Manish M.] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA. [de Oliveira, Lucia Helena] Pan Amer Hlth Org, Washington, DC USA. RP Desai, R (reprint author), Ctr Dis Control & Prevent, Div Viral Dis, 1600 Clifton Rd NE,MS-A47, Atlanta, GA 30333 USA. EM rdesai1@cdc.gov NR 27 TC 32 Z9 32 U1 0 U2 4 PU FUNDACO OSWALDO CRUZ PI RIO DE JANEIRO, RJ PA AV BRASIL 4365, 21045-900 RIO DE JANEIRO, RJ, BRAZIL SN 0074-0276 J9 MEM I OSWALDO CRUZ JI Mem. Inst. Oswaldo Cruz PD DEC PY 2011 VL 106 IS 8 BP 907 EP 911 PG 5 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA 875XP UT WOS:000299068800002 PM 22241109 ER PT J AU Mattar, S Komar, N Young, G Alvarez, J Gonzalez, M AF Mattar, Salim Komar, Nicholas Young, Ginger Alvarez, Jaime Gonzalez, Marco TI Seroconversion for West Nile and St. Louis encephalitis viruses among sentinel horses in Colombia SO MEMORIAS DO INSTITUTO OSWALDO CRUZ LA English DT Article DE flavivirus; West Nile virus; St. Louis encephalitis virus; Colombia; equine ID ANTIBODIES AB We prospectively sampled flavivirus-naive horses in northern Colombia to detect West Nile virus (WNV) and St. Louis encephalitis virus (SLEV) seroconversion events, which would indicate the current circulation of these viruses. Overall, 331 (34.1%) of the 971 horses screened were positive for past infection with flaviviruses upon initial sampling in July 2006. During the 12-month study from July 2006-June 2007, 33 WNV seroconversions and 14 SLEV seroconversions were detected, most of which occurred in the department of Bolivar. The seroconversion rates of horses in Bolivar for the period of March-June 2007 reached 12.4% for WNV and 6.7% for SLEV. These results comprise the first serologic evidence of SLEV circulation in Colombia. None of the horses sampled developed symptoms of encephalitis within three years of initial sampling. Using seroconversions in sentinel horses, we demonstrated an active circulation of WNV and SLEV in northern Colombia, particularly in the department of Bolivar. The absence of WNV-attributed equine or human disease in Colombia and elsewhere in the Caribbean Basin remains a topic of debate and speculation. C1 [Mattar, Salim; Alvarez, Jaime; Gonzalez, Marco] Univ Cordoba, Inst Invest Biol Trop, Cordoba, Colombia. [Komar, Nicholas; Young, Ginger] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA. RP Mattar, S (reprint author), Univ Cordoba, Inst Invest Biol Trop, Cordoba, Colombia. EM mattarsalim@hotmail.com FU COLCIENCIAS [414-2005, 1112-04-18258]; University of Cordoba FX COLCIENCIAS (414-2005, code 1112-04-18258), University of Cordoba NR 9 TC 11 Z9 11 U1 0 U2 2 PU FUNDACO OSWALDO CRUZ PI RIO DE JANEIRO, RJ PA AV BRASIL 4365, 21045-900 RIO DE JANEIRO, RJ, BRAZIL SN 0074-0276 J9 MEM I OSWALDO CRUZ JI Mem. Inst. Oswaldo Cruz PD DEC PY 2011 VL 106 IS 8 BP 976 EP 979 PG 4 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA 875XP UT WOS:000299068800012 PM 22241119 ER PT J AU Mueller, I Slutsker, L Tanner, M AF Mueller, Ivo Slutsker, Laurence Tanner, Marcel TI Estimating the Burden of Malaria: The Need for Improved Surveillance SO PLOS MEDICINE LA English DT Editorial Material C1 [Mueller, Ivo] Barcelona Ctr Int Hlth Res CRESIB, Barcelona, Spain. [Mueller, Ivo] Walter & Eliza Hall Inst Med Res, Parkville, Vic, Australia. [Slutsker, Laurence] Ctr Dis Control & Prevent, Ctr Global Hlth, Atlanta, GA USA. [Tanner, Marcel] Swiss Trop & Publ Hlth Inst, Basel, Switzerland. RP Mueller, I (reprint author), Barcelona Ctr Int Hlth Res CRESIB, Barcelona, Spain. EM ivomueller@fastmail.fm RI Mueller, Ivo/C-7251-2013 OI Mueller, Ivo/0000-0001-6554-6889 NR 8 TC 14 Z9 14 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1549-1277 J9 PLOS MED JI PLos Med. PD DEC PY 2011 VL 8 IS 12 AR e1001144 DI 10.1371/journal.pmed.1001144 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 870KM UT WOS:000298668100009 PM 22205884 ER PT J AU Miller, KS Lin, CY Poulsen, MN Fasula, A Wyckoff, SC Forehand, R Long, N Armistead, L AF Miller, Kim S. Lin, Carol Y. Poulsen, Melissa N. Fasula, Amy Wyckoff, Sarah C. Forehand, Rex Long, Nicholas Armistead, Lisa TI ENHANCING HIV COMMUNICATION BETWEEN PARENTS AND CHILDREN: EFFICACY OF THE PARENTS MATTER! PROGRAM SO AIDS EDUCATION AND PREVENTION LA English DT Article ID ADOLESCENT SEXUAL-BEHAVIOR; UNITED-STATES; CONDOM USE; RISK; FAMILY; AMERICAN; PATTERNS; MOTHERS; PERCEPTIONS; IMPACT AB We examine efficacy of the Parents Matter! Program (PMP), a program to teach African-American parents of preadolescents sexual communication and HIV-prevention skills, through a multicenter, randomized control trial. A total of 1115 parent-child participants were randomized to one of three intervention arms (enhanced, brief, control). Percentages and 95% confidence intervals compare parents' perception of child readiness to learn about sexual issues, communication effectiveness, and dyad concordance from baseline to 12 months postintervention. Wilcoxon rank sum tests compare the changes in scores measuring communication content in HIV/AIDS, abstinence, and condom use. Compared to control, parents in the enhanced arm increased perception of child readiness to learn about sex (16% vs. 29%; p < .001), and a greater proportion of parent-child dyads reported concordant responses on communication topics: HIV/AIDS (15%, 95% CI = 8-21%; p < .001), abstinence (13%, 95% CI = 7-20%; p < .001), condoms (15%, 95% CI = 9-22%; p < .001). Increases in communication scores in HIV/AIDS, abstinence, and condom use were greater in the enhanced arm than control (p < 0.01). We conclude that the enhanced PMP can help parents educate children about HIV and prepare children to avoid sexual risk. C1 [Miller, Kim S.; Poulsen, Melissa N.] Ctr Dis Control & Prevent CDC, Ctr Global Hlth, Div Global AIDS, Atlanta, GA USA. [Lin, Carol Y.] CDC, Div STD Prevent, Atlanta, GA 30333 USA. [Fasula, Amy] CDC, Div HIV AIDS Prevent, NCHHSTP, Atlanta, GA 30333 USA. [Wyckoff, Sarah C.] Univ N Carolina, Chapel Hill, NC USA. [Forehand, Rex] Univ Vermont, Burlington, VT 05405 USA. [Long, Nicholas] Univ Arkansas, Med Sci Ctr, Little Rock, AR 72204 USA. [Armistead, Lisa] Georgia State Univ, Atlanta, GA 30303 USA. RP Miller, KS (reprint author), Ctr Dis Control & Prevent, Ctr Global Hlth, Div Global HIV AIDS, 1600 Clifton Rd NE,Mailstop E-04, Atlanta, GA 30333 USA. EM kmiller@cdc.gov NR 39 TC 8 Z9 8 U1 0 U2 9 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 0899-9546 J9 AIDS EDUC PREV JI Aids Educ. Prev. PD DEC PY 2011 VL 23 IS 6 BP 550 EP 563 PG 14 WC Education & Educational Research; Public, Environmental & Occupational Health SC Education & Educational Research; Public, Environmental & Occupational Health GA 860PT UT WOS:000297960900006 PM 22201238 ER PT J AU Joseph, HA Fasula, AM Morgan, RL Stuckey, A Alvarez, ME Margolis, A Stratford, D Dooley, SW AF Joseph, Heather A. Fasula, Amy M. Morgan, Rebecca L. Stuckey, Amy Alvarez, Maria E. Margolis, Andrew Stratford, Dale Dooley, Samuel W., Jr. TI "THE ANTICIPATION ALONE COULD KILL YOU": PAST AND POTENTIAL CLIENTS' PERSPECTIVES ON HIV TESTING IN NON-HEALTH CARE SETTINGS SO AIDS EDUCATION AND PREVENTION LA English DT Article ID COMMUNITY SETTINGS; UNITED-STATES; HIGH-RISK; PREVENTION; OUTREACH; BEHAVIOR; INTERVENTIONS; PERCEPTIONS; STRATEGY; STIGMA AB HIV testing in non-health care settings is an effective strategy for increasing the proportion of persons aware of their infection. We conducted 21 focus groups with 186 past and potential clients in five U.S. cities to explore attitudes and experiences related to HIV counseling and testing in non-health care settings. Qualitative analysis yielded several key themes. HIV-related stigma and fear emerged as a main theme throughout the discussions. Knowing one's HIV status quickly and accurately was of primary importance; HIV prevention counseling was secondary. Participants prioritized a supportive, nonjudgmental environment with adequate privacy and confidentiality. Provision of immediate emotional support, medical information, and linkage services to HIV-infected clients were considered essential. Staff with HIV-specific skills to address clients' emotional and informational needs was considered a strength of non-health care testing programs. Frequently, however, participants compared non-health care settings unfavorably to health care settings regarding privacy, competency, confidentiality, and test accuracy. Recommendations for enhancing counseling and testing services in non-health care settings are discussed. C1 [Joseph, Heather A.; Fasula, Amy M.; Morgan, Rebecca L.; Stuckey, Amy; Alvarez, Maria E.; Margolis, Andrew; Stratford, Dale; Dooley, Samuel W., Jr.] Ctr Dis Control & Prevent CDC, Div HIV AIDS Prevent, Atlanta, GA USA. RP Joseph, HA (reprint author), 1600 Clifton Rd NE,Mailstop E-37, Atlanta, GA 30333 USA. EM HJoseph1@cdc.gov NR 31 TC 8 Z9 8 U1 2 U2 3 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 0899-9546 J9 AIDS EDUC PREV JI Aids Educ. Prev. PD DEC PY 2011 VL 23 IS 6 BP 577 EP 594 PG 18 WC Education & Educational Research; Public, Environmental & Occupational Health SC Education & Educational Research; Public, Environmental & Occupational Health GA 860PT UT WOS:000297960900008 PM 22201240 ER PT J AU Jarell, AD Dans, MJ Elston, DM Mathison, BA Ruben, BS AF Jarell, Abel D. Dans, Michael J. Elston, Dirk M. Mathison, Blaine A. Ruben, Beth S. TI Gnathostomiasis in a Patient Who Frequently Consumes Sushi SO AMERICAN JOURNAL OF DERMATOPATHOLOGY LA English DT Article DE gnathostomiasis; parasitic infection; cutaneous parasitosis; larva migrans profundus; nodular migratory eosinophilic panniculitis ID EMERGING IMPORTED DISEASE AB A 45-year-old woman presented for evaluation of a solitary pruritic nodule on the abdomen that suddenly appeared 3 weeks before. She was healthy without a significant medical history, travel history, exposures, medications, or pets. She reported that she consumed sushi at least weekly in the city of San Francisco. A punch biopsy revealed a superficial and deep perivascular and interstitial infiltrates consisting of lymphocytes, plasma cells, and many eosinophils. Most notably, there was a parasite centered in the reticular dermis with prominent lateral chords, a well-developed muscular esophagus, and an intestine that contained a brush border and multinucleate cells. Evaluation of these histological sections by the Centers for Disease Control and Prevention determined the parasite to be a nematode of the genus Gnathostoma. The patient underwent a systemic work-up for gnathostomiasis, including imaging, and no other abnormalities were found. She completed a 3-week course of albendazole and has remained asymptomatic since the biopsy of her abdominal lesion. Although gnathostomiasis is often a systemic illness, this patient did well with apparently only localized cutaneous disease. Gnathostomiasis should be considered in patients who present with nonspecific papules and nodules, especially when there is a history of frequent consumption of raw fish. C1 [Jarell, Abel D.; Dans, Michael J.; Ruben, Beth S.] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA. [Jarell, Abel D.; Ruben, Beth S.] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94140 USA. [Elston, Dirk M.] Geisinger Med Ctr, Dept Dermatol, Danville, PA 17822 USA. [Mathison, Blaine A.] Ctr Dis Control & Prevent, Dept Parasitol, Atlanta, GA USA. RP Ruben, BS (reprint author), UCSF Dermatopathol Serv, 1701 Divisadero,Suite 499, San Francisco, CA 94115 USA. EM beth.ruben@ucsf.edu NR 9 TC 6 Z9 6 U1 1 U2 14 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0193-1091 J9 AM J DERMATOPATH JI Am. J. Dermatopathol. PD DEC PY 2011 VL 33 IS 8 BP E91 EP E93 DI 10.1097/DAD.0b013e31821cf4a6 PG 3 WC Dermatology SC Dermatology GA 862JT UT WOS:000298087700002 PM 22024572 ER PT J AU de Oliveira, AM Mutemba, R Morgan, J Streat, E Roberts, J Menon, M Mabunda, S AF de Oliveira, Alexandre Macedo Mutemba, Rosalia Morgan, Juliette Streat, Elizabeth Roberts, Jacquelin Menon, Manoj Mabunda, Samuel TI Prevalence of Malaria among Patients Attending Public Health Facilities in Maputo City, Mozambique SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID RAPID DIAGNOSTIC-TESTS; DAR-ES-SALAAM; SUB-SAHARAN AFRICA; SOUTHERN MOZAMBIQUE; APPRAISAL RUMA; URBAN MALARIA; TANZANIA; TRANSMISSION; CHILDREN; PERFORMANCE AB We conducted a health facility-based survey to estimate the prevalence of malaria among febrile patients at health facilities (HFs) in Maputo City. Patients answered a questionnaire on malaria risk factors and underwent malaria testing. A malaria case was defined as a positive result for malaria by microscopy in a patient with fever or history of fever in the previous 24 hours. Among 706 patients with complete information, 111 (15.7%) cases were identified: 105 were positive for Plasmodium falciparum only, two for Plasmodium ovule only, and four for both P. falciparum and P. ovale. Fever documented at study enrollment, age >= 5 years, rural HF, and travel outside Maputo City were statistically significantly associated with malaria by multivariate analysis. We found a high prevalence of laboratory-confirmed malaria among febrile patients in Maputo City. Further studies are needed to relate these findings with mosquito density to better support malaria prevention and control. C1 [de Oliveira, Alexandre Macedo] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Atlanta, GA 30333 USA. [Mutemba, Rosalia] Minist Saude Mocambique, Maputo, Mozambique. [Streat, Elizabeth] Malaria Consortium Africa Reg Off, Kampala, Uganda. [Mabunda, Samuel] Univ Eduardo Mondlane, Maputo, Mozambique. Ctr Dis Control & Prevent, Off Director, Div Parasit Dis & Malaria, Atlanta, GA 30333 USA. RP de Oliveira, AM (reprint author), Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, 1600 Clifton Rd,MS A-06, Atlanta, GA 30333 USA. EM acq7@cdc.gov; rosalmutemba@yahoo.com.br; jmorgan@cdc.gov; e.streat@malariaconsortium.org; jmr1@il.cdc.gov; mmenon@gmail.com; sjamabunda@gmail.com FU United States Agency for International Development (USAID) through the President's Malaria Initiative (PMI) FX Funding for this evaluation was partially provided by the United States Agency for International Development (USAID) through the President's Malaria Initiative (PMI). The funding source for this study had no role in study design, data collection, analysis, or interpretation. NR 32 TC 7 Z9 7 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2011 VL 85 IS 6 BP 1002 EP 1007 DI 10.4269/ajtmh.2011.11-0365 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 858FJ UT WOS:000297781000008 ER PT J AU Steinhardt, LC Magill, AJ Arguin, PM AF Steinhardt, Laura C. Magill, Alan J. Arguin, Paul M. TI Review: Malaria Chemoprophylaxis for Travelers to Latin America SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Review ID PLASMODIUM-VIVAX MALARIA; PLACEBO-CONTROLLED TRIAL; NONIMMUNE COLOMBIAN SOLDIERS; DOUBLE-BLIND; UNITED-STATES; ATOVAQUONE-PROGUANIL; PRIMAQUINE PROPHYLAXIS; SURVEILLANCE; MEFLOQUINE; PREVENTION AB Because of recent declining malaria transmission in Latin America, some authorities have recommended against chemoprophylaxis for most travelers to this region. However, the predominant parasite species in Latin America, Plasmodium vivax, can form hypnozoites sequestered in the liver, causing malaria relapses. Additionally, new evidence shows the potential severity of vivax infections, warranting continued consideration of prophylaxis for travel to Latin America. Individualized travel risk assessments are recommended and should consider travel locations, type, length, and season, as well as probability of itinerary changes. Travel recommendations might include no precautions, mosquito avoidance only, or mosquito avoidance and chemoprophylaxis. There are a range of good options for chemoprophylaxis in Latin America, including atovaquone-proguanil, doxycycline, mefloquine, and-in selected areas-chloroquine. Primaquine should be strongly considered for nonpregnant, G6PD-nondeficient patients traveling to vivax-endemic areas of Latin America, and it has the added benefit of being the only drug to protect against malaria relapses. C1 [Steinhardt, Laura C.; Arguin, Paul M.] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Atlanta, GA 30333 USA. Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RP Steinhardt, LC (reprint author), Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Mailstop A06,1600 Clifton Road NE, Atlanta, GA 30333 USA. EM LSteinhardt@cdc.gov; alan.magill@us.army.mil; PArguin@cdc.gov NR 78 TC 9 Z9 9 U1 0 U2 5 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2011 VL 85 IS 6 BP 1015 EP 1024 DI 10.4269/ajtmh.2011.11-0464 PG 10 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 858FJ UT WOS:000297781000011 PM 22144437 ER PT J AU Hamel, MJ Otieno, P Bayoh, N Kariuki, S Were, V Marwanga, D Laserson, KF Williamson, J Slutsker, L Gimnig, J AF Hamel, Mary J. Otieno, Peter Bayoh, Nabie Kariuki, Simon Were, Vincent Marwanga, Doris Laserson, Kayla F. Williamson, John Slutsker, Laurence Gimnig, John TI The Combination of Indoor Residual Spraying and Insecticide-Treated Nets Provides Added Protection against Malaria Compared with Insecticide-Treated Nets Alone SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ANOPHELES-GAMBIAE; BED NETS; WESTERN KENYA; MORTALITY; TRANSMISSION; MORBIDITY; EFFICACY; AREA AB Both insecticide-treated bed nets (ITNs) and indoor residual spraying (IRS) reduce malaria in high malaria transmission areas.(1-3) The combined effect of these interventions is unknown. We conducted a non-randomized prospective cohort study to determine protective efficacy of IRS with ITNs (ITN + IRS) compared with ITNs alone (ITN only) in preventing Plasmodium falciparum parasitemia. At baseline, participants provided blood samples for malaria smears, were presumptively treated for malaria, and received ITNs. Blood smears were made monthly and at sick visits. In total, 1,804 participants were enrolled. Incidence of P falciparum parasitemia in the ITN + IRS and ITN only groups was 18 and 44 infections per 100 persons-years at risk, respectively (unadjusted rate ratio = 0.41; 95% confidence interval [CI] = 0.31-0.56). Adjusted protective efficacy of ITN + IRS compared with ITN only was 62% (95% CI = 0.50-0.72). The combination of IRS and ITN might be a feasible strategy to further reduce malaria transmission in areas of persistent perennial malaria transmission. C1 [Hamel, Mary J.] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA 30301 USA. RP Hamel, MJ (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, 1600 Clifton Rd, Atlanta, GA 30301 USA. EM mhamel@cdc.gov; potieno@ke.cdc.gov; nbayoh@ke.cdc.gov; skariuki@ke.cdc.gov; vwere@ke.cdc.gov; dmarwanga@ke.cdc.gov; klaserson@ke.cdc.gov; jwilliamson@ke.cdc.gov; lslutsker@cdc.gov; jgimnig@cdc.gov FU Bill and Melinda Gates Foundation through the Malaria Transmission Consortium [45114]; Malaria Transmission Consortium (MTC); Bill and Melinda Gates Foundation [45114] FX This work was supported by the Bill and Melinda Gates Foundation through the Malaria Transmission Consortium (Grant 45114).; This study was conducted as part of the Malaria Transmission Consortium (MTC) with support from the Bill and Melinda Gates Foundation Grant 45114. We would like to acknowledge the contributions of the MTC staff, the District Health Management Teams of Rachuonyo and Nyando. and the study participants. We would like to thank Daisy Abongo, Dr. Willis Akhwale, and Neil Lobo for their contributions. The authors thank the Director of the Center for Global Health Research, Kenya Medical Research Institute for his support. This paper was published with the approval of the KEMRI Director. NR 29 TC 42 Z9 42 U1 0 U2 7 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2011 VL 85 IS 6 BP 1080 EP 1086 DI 10.4269/ajtmh.2011.10-0684 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 858FJ UT WOS:000297781000022 PM 22144448 ER PT J AU Barrera, R AF Barrera, Roberto TI Spatial Stability of Adult Aedes aegypti Populations SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID DENGUE TRANSMISSION; PUERTO-RICO; PRODUCTIVITY; THAILAND; DIPTERA; QUEENSLAND; DISPERSAL; AUSTRALIA; CULICIDAE; EPIDEMIC AB Vector control programs could be more efficient by identifying the location of highly productive sites of Aedes aegypti. This study explored if the number of female adults of Ae. aegypti in BG-Sentinel traps was clustered and if their spatial distribution changed in time in two neighborhoods in San Juan. Puerto Rico. Traps were uniformly distributed across each neighborhood (130 m from each other), and samples were taken every 3 weeks. Global and local spatial autocorrelations were explored. Spatial stability existed if the rank order of trap captures was kept in time. There was lack of global autocorrelation in both neighborhoods, precluding their stratification for control purposes. Hot and cold spots were identified, revealing the highly focal nature of Ae. aegypti. There. was significant spatial stability throughout the study in both locations. The consistency in trap productivity in time could be used to increase the effectiveness of vector and dengue control programs. C1 Ctr Dis Control & Prevent, Dengue Branch, San Juan, PR 00920 USA. RP Barrera, R (reprint author), Ctr Dis Control & Prevent, Dengue Branch, Calle Canada, San Juan, PR 00920 USA. EM rbarrera@cdc.gov NR 34 TC 19 Z9 19 U1 2 U2 14 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2011 VL 85 IS 6 BP 1087 EP 1092 DI 10.4269/ajtmh.2011.11-0381 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 858FJ UT WOS:000297781000023 PM 22144449 ER EF