FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Thompson, WW Weintraub, E Dhankhar, P Cheng, PY Brammer, L Meltzer, MI Bresee, JS Shay, DK AF Thompson, William W. Weintraub, Eric Dhankhar, Praveen Cheng, Po-Yung Brammer, Lynnette Meltzer, Martin I. Bresee, Joseph S. Shay, David K. TI Estimates of US influenza-associated deaths made using four different methods SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article DE Excess mortality; human; Influenza; mortality ID UNITED-STATES; MORTALITY SURVEILLANCE; COST-EFFECTIVENESS; OUTPATIENT VISITS; YOUNG-CHILDREN; PNEUMONIA; HOSPITALIZATIONS; VACCINATION; EPIDEMICS; IMPACT AB Background A wide range of methods have been used for estimating influenza-associated deaths in temperate countries. Direct comparisons of estimates produced by using different models with US mortality data have not been published. Objective Compare estimates of US influenza-associated deaths made by using four models and summarize strengths and weaknesses of each model. Methods US mortality data from the 1972-1973 through 20022003 respiratory seasons and World Health Organization influenza surveillance data were used to estimate influenza-associated respiratory and circulatory deaths. Four models were used: (i) rate-difference (using peri-season or summer-season baselines), (ii) Serfling least squares cyclical regression, (iii) Serfling-Poisson regression, (iv) and autoregressive integrated moving average models. Results Annual estimates of influenza-associated deaths made using each model were similar and positively correlated, except for estimates from the summer-season rate-difference model, which were consistently higher. From the 1976/1977 through the 2002/2003 seasons the, the Poisson regression models estimated that an annual average of 25 470 [95% confidence interval (CI) 19 781-31 159] influenza-associated respiratory and circulatory deaths [9.9 deaths per 100 000 (95% CI 7.9-11.9)], while peri-season rate-difference models using a 15% threshold estimated an annual average of 22 454 (95% CI 16 189-28 719) deaths [8.6 deaths per 100 000 (95% CI 6.4-10.9)]. Conclusions Estimates of influenza-associated mortality were of similar magnitude. Poisson regression models permit the estimation of deaths associated with influenza A and B, but require robust viral surveillance data. By contrast, simple peri-season rate-difference models may prove useful for estimating mortality in countries with sparse viral surveillance data or complex influenza seasonality. C1 [Thompson, William W.; Cheng, Po-Yung; Brammer, Lynnette; Bresee, Joseph S.; Shay, David K.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Weintraub, Eric] Ctr Dis Control & Prevent, Immunizat Safety Off, Off Chief Sci Officer, Atlanta, GA USA. [Dhankhar, Praveen; Meltzer, Martin I.] Ctr Dis Control & Prevent, Div Emerging Infect & Surveillance Serv, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA USA. RP Shay, DK (reprint author), US Ctr Dis Control & Prevent, Influenza Div, Mailstop A32,1600 Clifton RD NE, Atlanta, GA 30333 USA. EM dks4@cdc.gov OI Shay, David/0000-0001-9619-4820 FU US Centers for Disease Control and Prevention FX The work presented in this manuscript was funded solely by the US Centers for Disease Control and Prevention. The findings and conclusions in this study are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 34 TC 100 Z9 106 U1 2 U2 7 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1750-2640 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD JAN PY 2009 VL 3 IS 1 BP 37 EP 49 DI 10.1111/j.1750-2659.2009.00073.x PG 13 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 467SE UT WOS:000267761900005 PM 19453440 ER PT J AU Dunn, K Devaux, I Stock, A Naeher, L AF Dunn, Kevin H. Devaux, Isabelle Stock, Allison Naeher, Luke P. TI Application of End-Exhaled Breath Monitoring to Assess Carbon Monoxide Exposures of Wildland Firefighters at Prescribed Burns SO INHALATION TOXICOLOGY LA English DT Article ID RESPIRATORY SYMPTOMS; PULMONARY-FUNCTION; LUNG-FUNCTION; SMOKE AB Exposure to the range of combustion products from wildland fires has been demonstrated to cause respiratory irritation and decreased lung function among firefighters. The measurement of carbon monoxide (CO) has been previously shown to be highly correlated with the range of contaminants found in wildland fires. In this article, we assess the feasibility of using a simple, noninvasive biological test to assess exposure to CO for a group of wildland firefighters. Measurements of CO exposure were collected using personal monitors as well as in exhaled breath for wildland firefighters who conducted prescribed burns in February-March 2004. Overall, the CO concentrations measured in this study group were low with a shift mean of 1.87 ppm. Correspondingly, the cross-shift difference in carboxyhemoglobin as estimated from exhaled breath CO levels was also low (median increase =+0.2% carboxyhemoglobin). The use of exhaled breath measurements for CO has limitations in characterizing exposures within this worker population. C1 [Naeher, Luke P.] Univ Georgia, Coll Publ Hlth, Dept Environm Hlth Sci, Athens, GA 30602 USA. [Dunn, Kevin H.; Devaux, Isabelle; Stock, Allison] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Naeher, L (reprint author), Univ Georgia, Coll Publ Hlth, Dept Environm Hlth Sci, 206 Environm Hlth Sci Bldg, Athens, GA 30602 USA. EM LNaeher@gmail.com RI Dunn, Kevin/I-2195-2012 FU U. S. Department of Agriculture Forest Service FX This research was supported by the U. S. Department of Agriculture Forest Service and approved by the University of Georgia Institutional Review Board for the inclusion of human subjects. The authors gratefully acknowledge Jeff Prevey, Mark Frizzell, Dan Shea, John Blake, Chris Hobson, Jason Demas, and the firefighters participating in this study. NR 14 TC 6 Z9 6 U1 0 U2 5 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0895-8378 J9 INHAL TOXICOL JI Inhal. Toxicol. PY 2009 VL 21 IS 1 BP 55 EP 61 AR PII 904707048 DI 10.1080/08958370802207300 PG 7 WC Toxicology SC Toxicology GA 387GK UT WOS:000261939500005 PM 18946764 ER PT S AU Kuempel, ED Vallyathan, V Green, FHY AF Kuempel, E. D. Vallyathan, V. Green, F. H. Y. BE Kenny, L TI Emphysema and Pulmonary Impairment in Coal Miners: Quantitative Relationship with Dust Exposure and Cigarette Smoking SO INHALED PARTICLES X SE Journal of Physics Conference Series LA English DT Meeting Abstract CT 10th International Symposium on Inhaled Particles CY SEP 23-25, 2008 CL Sheffield, ENGLAND C1 [Kuempel, E. D.] NIOSH, Educ & Informat Div, Risk Evaluat Branch, Cincinnati, OH 45226 USA. EM ekuempel@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 1742-6588 J9 J PHYS CONF SER PY 2009 VL 151 PG 1 WC Public, Environmental & Occupational Health; Respiratory System; Toxicology SC Public, Environmental & Occupational Health; Respiratory System; Toxicology GA BNH91 UT WOS:000274607800040 ER PT S AU Kuempel, ED Smith, RJ Dankovic, DA Stayner, LT AF Kuempel, E. D. Smith, R. J. Dankovic, D. A. Stayner, L. T. BE Kenny, L TI Rat- and Human-based Risk Estimates of Lung Cancer from Occupational Exposure to Poorly-Soluble Particles: A Quantitative Evaluation SO INHALED PARTICLES X SE Journal of Physics Conference Series LA English DT Meeting Abstract CT 10th International Symposium on Inhaled Particles CY SEP 23-25, 2008 CL Sheffield, ENGLAND C1 [Kuempel, E. D.; Smith, R. J.; Dankovic, D. A.] NIOSH, Educ & Informat Div, Cincinnati, OH 45226 USA. EM ekuempel@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 1742-6588 J9 J PHYS CONF SER PY 2009 VL 151 PG 1 WC Public, Environmental & Occupational Health; Respiratory System; Toxicology SC Public, Environmental & Occupational Health; Respiratory System; Toxicology GA BNH91 UT WOS:000274607800014 ER PT S AU Kuempel, ED Vallyathan, V Green, FHY AF Kuempel, E. D. Vallyathan, V. Green, F. H. Y. BE Kenny, L TI Emphysema and Pulmonary Impairment in Coal Miners: Quantitative Relationship with Dust Exposure and Cigarette Smoking SO INHALED PARTICLES X SE Journal of Physics Conference Series LA English DT Proceedings Paper CT 10th International Symposium on Inhaled Particles CY SEP 23-25, 2008 CL Sheffield, ENGLAND ID LUNG-FUNCTION; WORKERS; AIRWAYS AB Coal miners have been shown to be at increased risk of developing chronic obstructive pulmonary diseases including emphysema. The objective of this study was to determine whether lifetime cumulative exposure to respirable coal mine dust is a significant predictor of developing emphysema at a clinically-relevant level of severity by the end of life, after controlling for cigarette smoking and other covariates. Clinically-relevant emphysema severity was determined from the association between individuals' lung function during life (forced expiratory volume in one second, FEV1, as a percentage of predicted normal values) and emphysema severity at autopsy (as the proportion of lung tissue affected). In a logistic regression model, cumulative exposure to respirable coal mine dust was a statistically significant predictor of developing clinically-relevant emphysema severity, among both ever-smokers and never-smokers. The odds ratio for developing emphysema associated with FEV1 < 80% at the cohort mean cumulative coal dust exposure (87 mg/m(3) x yr) was 2.30 (1.46-3.64, 95% confidence limits), and at the cohort mean cigarette smoking (among smokers: 42 pack-years) was 1.95 (1.39-2.79). C1 [Kuempel, E. D.] NIOSH, Educ & Informat Div, Risk Evaluat Branch, Cincinnati, OH 45226 USA. [Vallyathan, V.] NIOSH, Hlth Effects Lab Div, Pathol & Physiol Res Branch, Morgantown, WV 45226 USA. [Green, F. H. Y.] Univ Calgary, Fac Med, Dept Pathol, Calgary, AB T2N 1N4, Canada. RP Kuempel, ED (reprint author), NIOSH, Educ & Informat Div, Risk Evaluat Branch, Cincinnati, OH 45226 USA. EM ekuempel@cdc.gov NR 20 TC 1 Z9 1 U1 0 U2 0 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 1742-6588 J9 J PHYS CONF SER PY 2009 VL 151 AR UNSP 012024 DI 10.1088/1742-6596/151/1/012024 PG 8 WC Public, Environmental & Occupational Health; Respiratory System; Toxicology SC Public, Environmental & Occupational Health; Respiratory System; Toxicology GA BNH91 UT WOS:000274607800126 ER PT S AU Kuempel, ED Smith, RJ Dankovic, DA Stayner, LT AF Kuempel, E. D. Smith, R. J. Dankovic, D. A. Stayner, L. T. BE Kenny, L TI Rat- and Human-based Risk Estimates of Lung Cancer from Occupational Exposure to Poorly-Soluble Particles: A Quantitative Evaluation SO INHALED PARTICLES X SE Journal of Physics Conference Series LA English DT Proceedings Paper CT 10th International Symposium on Inhaled Particles CY SEP 23-25, 2008 CL Sheffield, ENGLAND ID CHRONIC INHALATION EXPOSURE; TITANIUM-DIOXIDE; CARBON-BLACK; DIESEL EXHAUST; COAL-MINERS; PULMONARY RESPONSE; CRYSTALLINE SILICA; COHORT MORTALITY; DUST EXPOSURE; WORKERS AB In risk assessment there is a need for quantitative evaluation of the capability of animal models to predict disease risks in humans. In this paper, we compare the rat-and human-based excess risk estimates for lung cancer from working lifetime exposures to inhaled poorly-soluble particles. The particles evaluated include those for which long-term dose-response data are available in both species, i.e., coal dust, carbon black, titanium dioxide, silica, and diesel exhaust particulate. The excess risk estimates derived from the rat data were generally lower than those derived from the human studies, and none of the rat-and human-based risk estimates were significantly different (all p-values >= 0.05). Residual uncertainty in whether the rat-based risk estimates would over-or under-predict the true excess risks of lung cancer from inhaled poorly-soluble particles in humans is due in part to the low power of the available human studies, limited particle size exposure data for humans, and ambiguity about the best animal models and extrapolation methods. C1 [Kuempel, E. D.; Smith, R. J.; Dankovic, D. A.] NIOSH, Educ & Informat Div, Risk Evaluat Branch, Cincinnati, OH 45226 USA. [Stayner, L. T.] Univ Chicago, Sch Publ Hlth, Div Epidemiol & Biostat, Chicago, IL 60637 USA. RP Kuempel, ED (reprint author), NIOSH, Educ & Informat Div, Risk Evaluat Branch, Cincinnati, OH 45226 USA. EM ekuempel@cdc.gov NR 53 TC 3 Z9 3 U1 0 U2 2 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 1742-6588 J9 J PHYS CONF SER PY 2009 VL 151 AR UNSP 012011 DI 10.1088/1742-6596/151/1/012011 PG 12 WC Public, Environmental & Occupational Health; Respiratory System; Toxicology SC Public, Environmental & Occupational Health; Respiratory System; Toxicology GA BNH91 UT WOS:000274607800113 ER PT B AU Levin, ML AF Levin, Michael L. BE Connell, CI Ralston, DP TI Effects of Coinfection with Borrelia Burgdorferi and Anaplasma Phagocytophilum in Vector Ticks and Vertebrate Hosts SO INSECT VIRUSES: DETECTION, CHARACTERIZATION AND ROLES SE Virology Research Progress LA English DT Article; Book Chapter ID HUMAN GRANULOCYTIC EHRLICHIOSIS; IXODES-RICINUS TICKS; LYME-DISEASE SEROLOGY; BORNE FEVER; BABESIA-MICROTI; SENSU-LATO; CYTOECETES-PHAGOCYTOPHILA; SOUTHERN GERMANY; SCAPULARIS ACARI; HGE AGENT AB Agents of Lyme disease - Borrelia burgdorferi and human granulocytic anaplasmosis - Anaplasma phagocytophilum (formerly Anaplasma phagocytophila) are perpetuated in natural cycles involving the black-legged tick (Ixodes scapularis) and its vertebrate hosts. This predetermines the exposure of humans as well as wild and domestic animals to both pathogens and consequent concurrent infections. We studied whether a preexisting infection with either Borrelia or Anaplasma would affect acquisition and transmission of a second pathogen in ticks and their mammalian hosts. Also, we assessed the efficiency by which individual nymphs could transmit either agent alone or both agents simultaneously, to individual susceptible hosts. There was no evidence of interaction between the agents of Lyme disease and human granulocytic anaplasmosis in I. scapularis ticks. The presence of either agent in ticks did not affect acquisition of the other agent from an infected host. Transmission of the agents of Lyme disease and human granulocytic anaplasmosis by individual ticks was equally efficient and independent. Dually infected ticks transmitted each pathogen to susceptible hosts as efficiently as ticks infected with one pathogen only. On the other hand, a primary infection with either B. burgdorferi or A. phagocytophilum in mice inhibited acquisition and transmission of a second agent, suggesting interference between these two agents in a vertebrate host. Consequences of co-infection in ticks, wild animals and humans are discussed. C1 Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Levin, ML (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. NR 121 TC 0 Z9 0 U1 1 U2 4 PU NOVA SCIENCE PUBLISHERS, INC PI HAUPPAUGE PA 400 OSER AVE, STE 1600, HAUPPAUGE, NY 11788-3635 USA BN 978-1-60692-965-0 J9 VIROL RES PROG PY 2009 BP 119 EP 145 PG 27 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA BKU47 UT WOS:000269270000007 ER PT J AU Doney, B Greskevitch, M Groce, D Syamlal, G Bang, KM AF Doney, Brent Greskevitch, Mark Groce, Dennis Syamlal, Girija Bang, Ki Moon TI Respirator Use and Practices in Instruments and Related Products Manufacturing Establishments: Results of a National Survey of Private Sector Employers SO INSTRUMENTATION SCIENCE & TECHNOLOGY LA English DT Article DE Questionnaires; Respirators; Respiratory system disorders; Silica dusts; Worker health AB In 2001, the Survey of Respirator Use and Practices gathered information on respirator use from 40,002 private U.S. establishments including the types of respirators used by workers, assessment of medical fitness to wear respirators, types of respirator fit tests, and presence of substances that prompted respirator use. Of respirator-using Instruments Manufacturing establishments, 22% did not provide training regarding the need, use, limitations, and capabilities of respirators; 37% did not provide assessment for medical fitness to wear respirators or didn't know if such an assessment was conducted; and 68% had three or more indicators of a potentially inadequate respiratory protection program. C1 [Doney, Brent; Greskevitch, Mark; Syamlal, Girija; Bang, Ki Moon] Ctr Dis Control & Prevent, NIOSH, Div Resp Dis Studies, Morgantown, WV 26505 USA. [Groce, Dennis] EG&G Tech Serv Inc, Pittsburgh, PA USA. RP Greskevitch, M (reprint author), Ctr Dis Control & Prevent, NIOSH, Div Resp Dis Studies, 1095 Willowdale Rd,Mail Stop HG-900-2, Morgantown, WV 26505 USA. EM bdoney@cdc.gov NR 11 TC 0 Z9 0 U1 0 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1073-9149 J9 INSTRUM SCI TECHNOL JI Instrum. Sci. Technol. PY 2009 VL 37 IS 3 BP 359 EP 365 AR PII 910366170 DI 10.1080/10739140902832063 PG 7 WC Chemistry, Analytical; Instruments & Instrumentation SC Chemistry; Instruments & Instrumentation GA 434SW UT WOS:000265295400008 ER PT J AU Zocoli, AMF Morata, TC Marques, JM Corteletti, LJ AF Fontana Zocoli, Angela Maria Morata, Thais Catalani Marques, Jair Mendes Corteletti, Lilian Jacob TI Brazilian young adults and noise: Attitudes, habits, and audiological characteristics SO INTERNATIONAL JOURNAL OF AUDIOLOGY LA English DT Article DE Demographics/epidemiology; Hearing conservation; Tinnitus; Psycho-social/emotional ID PERSONAL LISTENING DEVICES; HEARING-LOSS; LEISURE NOISE; EXPOSURE; ADOLESCENTS; RISK AB The objective of this study was to examine behaviors and attitudes of Brazilian teenagers towards noise, and determine their audiological characteristics. Participants were 245 young persons (14 to 18 years old) who attended private school. Behaviors and attitudes were measured using the validated Portuguese version of the Youth Attitude to Noise Scale (YANS). Pure-tone audiometry was used to evaluate the hearing of a sub-sample of 24 participants. Music played through personal media players was the most common exposure reported. A substantial percentage of participants reported temporary tinnitus (69%) after attending discos, music concerts, and listening to music through headphones. Tinnitus complaints were more frequent among females (41%) than males (27%). Four participants (1.6%) reported use of a hearing protector. Among a sub-sample of 24 participants, two (8%) young women had bilateral audiometric notches. YANS scores in the present study were slightly lower than those obtained in Sweden and the US, indicating a more negative attitude towards noise. Gender, age, country, and/or region are variables that will influence exposure to noise or music and possibly hearing outcomes. C1 [Morata, Thais Catalani] NIOSH, Hearing Loss Prevent Team, Div Appl Res & Technol, Cincinnati, OH 45226 USA. [Fontana Zocoli, Angela Maria; Morata, Thais Catalani; Marques, Jair Mendes; Corteletti, Lilian Jacob] Univ Tuiuti Parana, Grad Program Commun Disorders, Tuiuti, Parana, Brazil. RP Morata, TC (reprint author), NIOSH, Hearing Loss Prevent Team, Div Appl Res & Technol, 4676 Columbia Pkwy,Mail Stop C 27, Cincinnati, OH 45226 USA. RI Morata, Thais/A-6848-2009; Jacob-Corteletti , Lilian Cassia /I-9391-2012 NR 20 TC 14 Z9 18 U1 2 U2 19 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1499-2027 J9 INT J AUDIOL JI Int. J. Audiol. PY 2009 VL 48 IS 10 BP 692 EP 699 DI 10.1080/14992020902971331 PG 8 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 512NO UT WOS:000271256600003 PM 19863355 ER PT J AU Semaan, S Santibanez, S Garfein, RS Heckathorn, DD Des Jarlais, DC AF Semaan, Salaam Santibanez, Scott Garfein, Richard S. Heckathorn, Douglas D. Des Jarlais, Don C. TI Ethical and regulatory considerations in HIV prevention studies employing respondent-driven sampling SO INTERNATIONAL JOURNAL OF DRUG POLICY LA English DT Article; Proceedings Paper CT 15th International AIDS Conference CY JUL 11-17, 2004 CL Bangkok, THAILAND DE Respondent-driven sampling; Injection-drug user; Ethics; HIV disclosure; Incentives; Sexual risk; Hidden populations; Men who have sex with men ID INJECTING DRUG-USERS; PUBLIC-HEALTH SURVEILLANCE; NEW-YORK-CITY; PARTNER NOTIFICATION; HIDDEN POPULATIONS; INFORMED-CONSENT; TRANSMISSION RATES; RISK BEHAVIORS; UNITED-STATES; AIDS AB Objective: To review the scientific, ethical, and regulatory literature because no official guidance exists on remuneration for participant-driven recruitment or on investigators' responsibilities for informing participants of their discordant partnerships. Methods: We reviewed the studies that used RDS to recruit injection-drug users (IDUs), 1995-2006, and the relevant scientific, ethical, and regulatory literature that shed light on arguments for and against practices that can be used in studies employing RDS. Results: Concerns that payments can be used to buy drugs or can subvert altruistic motivations for study participation are not supported by the literature. Concerns about peers' coercion to barter coupons or surrender payments are offset by safeguards used in RDS. Remuneration shows respect for participants' time and effort in recruitment and judgment to use remuneration for personal needs. Tension between ensuring participants' confidentiality and protecting the health of network members highlights difference in roles between investigators and health care providers. Investigators can choose to rely on public health agencies for partner notification services, ask participants if and how they would like to be informed of their discordant partnerships, and offer training on how to disclose HIV status and adopt risk-reduction and harm-reduction behaviours. Conclusion: Clarifying ethical and regulatory considerations is important for research sponsors, institutional review boards (IRBs), ethics review committees (ERCs), investigators, and participants. We provide a checklist of ethics and regulatory variables to be included as feasible in future studies to enhance development of evidence-based ethics. (C) 2008 Published by Elsevier B.V. C1 [Semaan, Salaam; Santibanez, Scott] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Garfein, Richard S.] Univ Calif San Diego, Sch Med, San Diego, CA 92103 USA. [Heckathorn, Douglas D.] Cornell Univ, Dept Sociol, Ithaca, NY 14853 USA. [Des Jarlais, Don C.] Beth Israel Deaconess Med Ctr, New York, NY 10003 USA. RP Semaan, S (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,NE,E-07, Atlanta, GA 30333 USA. EM ssemaan@cdc.gov FU NIDA NIH HHS [P30 DA 11041, R01 DA 03574] NR 109 TC 33 Z9 34 U1 2 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0955-3959 EI 1873-4758 J9 INT J DRUG POLICY JI Int. J. Drug Policy PD JAN PY 2009 VL 20 IS 1 BP 14 EP 27 DI 10.1016/j.drugpo.2007.12.006 PG 14 WC Substance Abuse SC Substance Abuse GA 395TN UT WOS:000262546500003 PM 18243679 ER PT J AU Norton, DM Rahman, M Shane, AL Hossain, Z Kulick, RM Bhuiyan, MI Wahed, MA Yunus, M Islam, MS Breiman, RF Henderson, A Keswick, BH Luby, SP AF Norton, Dawn M. Rahman, Mahfuz Shane, Andi L. Hossain, Zahid Kulick, Roy M. Bhuiyan, Mahbubul I. Wahed, M. Abdul Yunus, Mohammad Islam, M. Siraj Breiman, Robert F. Henderson, Alden Keswick, Bruce H. Luby, Stephen P. TI Flocculant-disinfectant point-of-use water treatment for reducing arsenic exposure in rural Bangladesh SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH LA English DT Article DE arsenic poisoning; water supply; water purification; urine; Bangladesh ID HOUSEHOLD DRINKING-WATER; CONTAMINATION; MITIGATION; GROUNDWATER; POPULATION; EXCRETION; ARAIHAZAR; PADDIES; IMPACT; URINE AB We introduced flocculant-disinfectant water treatment for 12 weeks in 103 households in Bangladesh to assess if drinking water would be chemically and microbiologically improved and the body burden of arsenic reduced. The median concentration of arsenic in tubewell water decreased by 88% after introduction of the flocculant-disinfectant from 136g/l at baseline to 16 (p0.001). The median concentration of total urinary arsenic decreased 42% from 385g/g creatinine at baseline to 225g/g creatinine after intervention (p0.001). Among 206 post-intervention drinking water samples that were reportedly treated on the date the sample was collected, 99 (48%) lacked residual free chlorine and 100 (49%) were contaminated with thermotolerant coliforms. The flocculant-disinfectant markedly reduced arsenic in drinking water, but treated drinking water was frequently contaminated with fecal organisms. The lesser reduction in urinary arsenic compared to water arsenic and the health consequences of this reduction require further research. C1 [Norton, Dawn M.; Shane, Andi L.; Breiman, Robert F.; Henderson, Alden; Luby, Stephen P.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Rahman, Mahfuz; Hossain, Zahid; Bhuiyan, Mahbubul I.; Wahed, M. Abdul; Yunus, Mohammad; Islam, M. Siraj; Breiman, Robert F.; Luby, Stephen P.] Bangladesh ICDDRB, Int Ctr Diarrheal Dis Res, Dhaka 1000, Bangladesh. [Kulick, Roy M.; Keswick, Bruce H.] Procter & Gamble Hlth Sci Inst, Mason, OH USA. RP Luby, SP (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,MS A38, Atlanta, GA 30333 USA. EM sluby@icddrb.org FU Proctor and Gamble Company; Centers for Disease Control and Prevention (CDC) FX We are indebted to Hashina Akter, Morzina Akter, Suporna Das, Sheuli Rani Dey, Nasreen Farzana, Fatema Khatun and Anutzupa Paul for their assistance in working with the community and collecting the data. This research study was funded by the Proctor and Gamble Company and the Centers for Disease Control and Prevention (CDC). NR 32 TC 4 Z9 4 U1 1 U2 3 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0960-3123 J9 INT J ENVIRON HEAL R JI Int. J. Environ. Health Res. PY 2009 VL 19 IS 1 BP 17 EP 29 AR PII 909031412 DI 10.1080/09603120802272219 PG 13 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 412HK UT WOS:000263715700002 PM 19241244 ER PT J AU Lee, TS Falter, K Meyer, P Mott, J Gwynn, C AF Lee, Tze-San Falter, Kenneth Meyer, Pamela Mott, Joshua Gwynn, Charon TI Risk factors associated with clinic visits during the 1999 forest fires near the Hoopa Valley Indian Reservation, California, USA SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH LA English DT Article DE asthma; confounding variable; wildfires; Hoopa valley; interaction; logistic regression; PM(10) levels; respiratory illness ID EXPOSURE; SMOKE AB Forest fires burned near the Hoopa Valley Indian Reservation in northern California from late August until early November in 1999. The fires generated particulate matter reaching hazardous levels. We assessed the relationship between patients seeking care for six health conditions and PM(10) exposure levels during the 1999 fires and during the corresponding period in 1998 when there were no fires. Multivariate logistic regression analysis indicated that daily PM(10) levels in 1999 were significant predictors for patients seeking care for asthma, coronary artery disease and headache after controlling for potential risk factors. Stratified multivariate logistic regression models indicated that daily PM(10) levels in 1999 were significant predictors for patients seeking care for circulatory illness among residents of nearby communities and new patients, and for respiratory illness among residents of Hoopa and those of nearby communities. C1 [Lee, Tze-San; Falter, Kenneth] CDC, NCEH, EHH, Chamblee, GA 30341 USA. [Meyer, Pamela] CDC, Off Director, CCEHIP, Chamblee, GA 30341 USA. [Mott, Joshua] CDC, Epidemiol & Prevent Branch, NCIRD, Atlanta, GA 30333 USA. [Gwynn, Charon] NYC Dept Hlth & Mental Hyg, Div Epidemiol, New York, NY USA. RP Lee, TS (reprint author), CDC, NCEH, EHH, Mail Stop F-58, Chamblee, GA 30341 USA. EM tjl3@cdc.gov NR 14 TC 15 Z9 15 U1 0 U2 5 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0960-3123 J9 INT J ENVIRON HEAL R JI Int. J. Environ. Health Res. PY 2009 VL 19 IS 5 BP 315 EP 327 DI 10.1080/09603120802712750 PG 13 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 508EA UT WOS:000270909500001 PM 19629821 ER PT J AU Kahende, JW Loomis, BR Adhikari, B Marshall, L AF Kahende, Jennifer W. Loomis, Brett R. Adhikari, Bishwa Marshall, LaTisha TI A Review of Economic Evaluations of Tobacco Control Programs SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH LA English DT Review DE Economic evaluation; cost-effectiveness; smoking; tobacco use; smoking cessation ID SMOKING-CESSATION PROGRAM; CLINICAL PREVENTIVE SERVICES; COST-EFFECTIVENESS ANALYSIS; FREE BAR LAW; FREE RESTAURANTS; UNITED-STATES; HEALTH; CALIFORNIA; PREGNANCY; INTERVENTION AB Each year, an estimated 443,000 people die of smoking-related diseases in the United States. Cigarette smoking results in more than $193 billion in medical costs and productivity losses annually. In an effort to reduce this burden, many states, the federal government, and several national organizations fund tobacco control programs and policies. For this report we reviewed existing literature on economic evaluations of tobacco control interventions. We found that smoking cessation therapies, including nicotine replacement therapy (NRT) and self-help are most commonly studied. There are far fewer studies on other important interventions, such as price and tax increases, media campaigns, smoke free air laws and workplace smoking interventions, quitlines, youth access enforcement, school-based programs, and community-based programs. Although there are obvious gaps in the literature, the existing studies show in almost every case that tobacco control programs and policies are either cost-saving or highly cost-effective. C1 [Kahende, Jennifer W.; Adhikari, Bishwa; Marshall, LaTisha] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Off Smoking & Hlth, Atlanta, GA 30341 USA. [Loomis, Brett R.] Res Triangle Int, Publ Hlth Policy Res Program, Res Triangle Pk, NC 27709 USA. RP Kahende, JW (reprint author), Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Off Smoking & Hlth, 4770 Buford Highway,NE,MS-K50, Atlanta, GA 30341 USA. EM Jkahende@cdc.gov; Loomis@rti.org; Badhikari@cdc.gov; Lmarshall@cdc.gov NR 72 TC 22 Z9 24 U1 5 U2 17 PU MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI PI BASEL PA KANDERERSTRASSE 25, CH-4057 BASEL, SWITZERLAND SN 1660-4601 J9 INT J ENV RES PUB HE JI Int. J. Environ. Res. Public Health PD JAN PY 2009 VL 6 IS 1 BP 51 EP 68 DI 10.3390/ijerph6010051 PG 18 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 449GK UT WOS:000266318600005 PM 19440269 ER PT J AU Naimoli, JF AF Naimoli, Joseph F. TI Global health partnerships in practice: taking stock of the GAVI Alliance's new investment in health systems strengthening SO INTERNATIONAL JOURNAL OF HEALTH PLANNING AND MANAGEMENT LA English DT Article ID PUBLIC-PRIVATE PARTNERSHIPS; IMMUNIZATION; LESSONS; WORLD; GOALS; FUND AB Despite a burgeoning literature oil global health partnerships (GHPs), there have been few Studies of how GHPs, particularly those trying to build a bridge between horizontal and vertical modes of delivering essential health services, operate at global and country levels. This paper will help address this knowledge gap by describing and analyzing the GAVI Alliance's early experience with health systems strengthening (HSS) to improve immunization coverage and other maternal-child health outcomes. To date, the strengths of HSS reside in its potential to optimize GAVI's overall investment in immunization. efforts to harmonize with other initiatives, willingness to acknowledge risk and identify mitigation strategies, engagement of diverse stakeholders, responsiveness to country needs, and effective management of an ambitious grant-making enterprise. The challenges have been forging a common vision and approach, governance, balancing pressure to move money with incremental learning, managing partner roles and relationships, managing the "value for money" risk, and capacity building. This mid-point stock-taking makes recommendations for moving GAVI forward in a thoughtful manner. The findings should be of interest to other GHPs because of their larger significance. This is a story about how a successful alliance that decided to broaden its mandate has responded to the technical, organizational, and political complexities that challenge its traditional business model. Copyright (C) 2009 John Wiley & Sons, Ltd. C1 Ctr Dis Control & Prevent, Natl Immunizat Program, Global Immunizat Div, Atlanta, GA 30333 USA. RP Naimoli, JF (reprint author), Ctr Dis Control & Prevent, Natl Immunizat Program, Global Immunizat Div, MS E-05,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM jan1@cdc.gov NR 41 TC 20 Z9 22 U1 1 U2 15 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0749-6753 J9 INT J HEALTH PLAN M JI Int. J. Health Plan. Manag. PD JAN-MAR PY 2009 VL 24 IS 1 BP 3 EP 25 DI 10.1002/hpm.969 PG 23 WC Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA 422QW UT WOS:000264443800001 PM 19165763 ER PT J AU Xu, XS Welcome, DE McDowell, TW Warren, C Dong, RG AF Xu, X. S. Welcome, D. E. McDowell, T. W. Warren, C. Dong, R. G. TI An investigation on characteristics of the vibration transmitted to wrist and elbow in the operation of impact wrenches SO INTERNATIONAL JOURNAL OF INDUSTRIAL ERGONOMICS LA English DT Article DE Hand-arm vibration; Hand-transmitted vibration; Impact wrench; Nut runner; Wrist ID CARPAL-TUNNEL SYNDROME; TOOL TORQUE REACTION; HAND-ARM; TRANSMISSION CHARACTERISTICS; OCCUPATIONAL EXPOSURES; FINGERS; FORCES; GLOVES AB To help assess the risk of the vibration exposure during impact wrench operation and to develop a convenient and effective method to monitor and control the exposure, this study aims to investigate the characteristics of the vibrations transmitted to the wrist and elbow in the operation and to evaluate the on-the-wrist and on-the-elbow vibration measurement methods. Six subjects participated in the experiment. Each of them used 15 impact wrenches on a simulated workstation. Tri-axial accelerations at three locations (tool handle, wrist, and elbow) and the tool effective torques were measured and used in the evaluations. Results confirm that the severity of the vibration exposure generally depends on tool and individual, and that the vibrations measured at wrist and elbow reflect the influences of both factors. This study also found that the accelerations measured at the wrist and elbow are correlated with the ISO frequency-weighted tool acceleration. The fundamental resonance of the hand-arm system in the range of 16-50 Hz is well reflected in the vibration measured at the wrist. The results also demonstrate that vibration exposure duration can be reliably detected from the wrist vibration data. Moreover, the wrist vibration is suggestively correlated with the torque of the pneumatic impact wrenches. These findings suggest that the measurement of the wrist vibration can be used as an alternative approach to perform the exposure risk assessment and to monitor and control the exposures in the operation of the impact wrenches. Relevance to Industry: Impact wrenches or nut runners with impact action are widely and intensively used in automobile manufacturing and repair, which could generate significant vibration and require forceful actions. Prolonged, intensive exposure to both vibration and forceful actions could result in hand-arm vibration syndrome and carpal tunnel syndrome. The results of this study suggest that the on-the-wrist vibration measurement is a reasonable alternative approach for quantifying and assessing the exposures, which provides a theoretical base for developing a convenient and effective method for monitoring and controlling the combined exposures. The results of this study also suggest that the on-the-wrist method can also be used at workplaces to perform screening tests of the tools with dominant vibration frequencies similar to those of the impact wrenches and to evaluate the effectiveness of the anti-vibration devices used with such tools. Published by Elsevier B.V. C1 [Xu, X. S.; Welcome, D. E.; McDowell, T. W.; Warren, C.; Dong, R. G.] NIOSH, Engn & Control Technol Branch, HELD, CDC, Morgantown, WV 26505 USA. RP Xu, XS (reprint author), NIOSH, Engn & Control Technol Branch, HELD, CDC, 1095 Willowdale Rd,MS L-2027, Morgantown, WV 26505 USA. EM xxu1@cdc.gov OI McDowell, Thomas/0000-0002-2416-2210 NR 33 TC 9 Z9 9 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-8141 J9 INT J IND ERGONOM JI Int. J. Ind. Ergon. PD JAN PY 2009 VL 39 IS 1 BP 174 EP 184 DI 10.1016/j.ergon.2008.05.006 PG 11 WC Engineering, Industrial; Ergonomics SC Engineering GA 402IO UT WOS:000263007600023 ER PT J AU McQueen, DV AF McQueen, David V. TI 25 years of HBSC: challenges and successes SO INTERNATIONAL JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material C1 [McQueen, David V.] Ctr Dis Control & Prevent, NCCDPHP, OD, Atlanta, GA 30341 USA. [McQueen, David V.] Univ Edinburgh, Res Unit Hlth & Behav Change, Edinburgh EH8 9YL, Midlothian, Scotland. [McQueen, David V.] Johns Hopkins Univ, Sch Hyg & Publ Hlth, Baltimore, MD USA. RP McQueen, DV (reprint author), Ctr Dis Control & Prevent, NCCDPHP, OD, 4770 Buford HWY NE K40, Atlanta, GA 30341 USA. EM dvm0@cdc.gov NR 1 TC 1 Z9 1 U1 0 U2 1 PU BIRKHAUSER VERLAG AG PI BASEL PA VIADUKSTRASSE 40-44, PO BOX 133, CH-4010 BASEL, SWITZERLAND SN 1661-8556 J9 INT J PUBLIC HEALTH JI Int. J. Public Health PY 2009 VL 54 BP 123 EP 124 DI 10.1007/s00038-009-5401-0 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 511KK UT WOS:000271162900002 PM 19639262 ER PT J AU Lopes, PEM Demchuk, E Mackerell, AD AF Lopes, Pedro E. M. Demchuk, Eugene Mackerell, Alexander D., Jr. TI Reconstruction of the (011) Surface on alpha-Quartz: A Semiclassical Ab Initio Molecular Dynamics Study SO INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY LA English DT Article; Proceedings Paper CT 16th Conference on Current Trends in Computational Chemistry CY NOV 02-03, 2007 CL Jackson State Univ, Jackson, MS SP USA Corps Engineers, USA Engineer Res & Dev Ctr HO Jackson State Univ DE silica toxicity; quartz; silicosis; molecular dynamics; density functional theory; surfaces ID HYDROXYL RADICAL GENERATION; CRYSTALLINE SILICA; REACTIVITY; TOXICITY; TRICLUSTERS; EXPOSURE; DENSITY; OXYGEN; SITES; DUSTS AB Ab initio molecular dynamics simulations have been performed on the (011) surface of alpha-quartz at room-temperature using density functional theory. Pristine surface was obtained by homolytic fracture of alpha-quartz crystal, leaving exposed SiO center dot. radicals, following which the surface was allowed to spontaneously reconstruct during the Simulation. Reconstruction events occurred at different timings but in most cases produced similar geometries. The most common motif consisted of a fused seven-member ring. Formation of this structure proceeded through reaction of two adjacent O-center dot radicals, followed by linking of one of the reactive O-center dot with a nearby silicon. Other structures, like Si2O2, were also observed. In the newly formed structures some of the silicon atoms had pentacoordinated geometry, usually distorted between pure bipyramidal, trigonal, and square pyramidal. In a few cases oxygen atoms also became tricoordinated. Formation of new bonds was investigated by analyzing the electronic structure of the system along the reaction path, and specifically the localization of unpaired electrons,vas deduced from the spin-density. Because most reactions involved triplet -> singlet transitions, a time-dependent density functional theory was used to C1 [Lopes, Pedro E. M.; Demchuk, Eugene] CDC, NIOSH, Morgantown, WV 26505 USA. [Lopes, Pedro E. M.; Mackerell, Alexander D., Jr.] Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Baltimore, MD 21201 USA. [Demchuk, Eugene] CDC, ATSDR, Div Toxicol & Environm Med, Atlanta, GA 30333 USA. [Demchuk, Eugene] W Virginia Univ, Sch Pharm, Morgantown, WV 26506 USA. RP Lopes, PEM (reprint author), CDC, NIOSH, Morgantown, WV 26505 USA. EM lopes@outerbanks.umaryland.edu RI Marques Lopes, pedro/A-8547-2009 OI Marques Lopes, pedro/0000-0002-7383-7886 NR 49 TC 8 Z9 8 U1 0 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0020-7608 EI 1097-461X J9 INT J QUANTUM CHEM JI Int. J. Quantum Chem. PD JAN PY 2009 VL 109 IS 1 SI SI BP 50 EP 64 DI 10.1002/qua.21726 PG 15 WC Chemistry, Physical; Mathematics, Interdisciplinary Applications; Physics, Atomic, Molecular & Chemical SC Chemistry; Mathematics; Physics GA 383JB UT WOS:000261668800008 ER PT J AU Peterman, TA Tian, LH Warner, L Satterwhite, CL Metcalf, CA Malotte, KC Paul, SM Douglas, JM AF Peterman, T. A. Tian, L. H. Warner, L. Satterwhite, C. L. Metcalf, C. A. Malotte, K. C. Paul, S. M. Douglas, J. M., Jr. CA Respect-2 Study Grp TI Condom use in the year following a sexually transmitted disease clinic visit SO INTERNATIONAL JOURNAL OF STD & AIDS LA English DT Article DE condoms; cohort; prevention; HIV; STD ID CONTROLLED-TRIAL; AIDS-PREVENTION; COMMUNITY TRIAL; CASE-CROSSOVER; UGANDA; PREVALENCE; CHLAMYDIA; DESIGN; GONORRHEA; RESPECT-2 AB Consistent condom use can prevent sexually transmitted infections (STIs), but few studies have measured how the prevalence of consistent use changes over time. We measured the prevalence and correlates of consistent condom use over the course of a year. We did a secondary analysis of data from an HIV prevention trial in three sexually transmitted disease clinics. We assessed condom use during four three-month intervals for subjects and across their partnerships using unconditional logistic regression. Condom use was also assessed for subjects during all three-month intervals combined. The 2125 subjects reported on 5364 three-month intervals including 7249 partnership intervals. Condoms were always used by 24.1% of subjects and 33.2% of partnerships during a three-month interval. Over the year, 82% used condoms at least once but only 5.1% always used condoms. Always use of condom was more likely for subjects who had sex only once (66.5%) compared with >30 times (6.4%); one-time partnerships (64.1%) compared with main partnerships (22.2%); and in new partnerships (44.0%) compared with partnerships that were not new (24.5%). Although consistent condom use may prevent STIs, condoms were rarely used consistently during the year of follow-up. C1 [Warner, L.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30333 USA. [Peterman, T. A.; Tian, L. H.; Satterwhite, C. L.; Douglas, J. M., Jr.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30333 USA. [Metcalf, C. A.] Human Sci Res Council, Pretoria, South Africa. [Malotte, K. C.] Calif State Univ Long Beach, Long Beach, CA 90840 USA. [Paul, S. M.] New Jersey Dept Hlth & Senior Serv, Trenton, NJ USA. RP Peterman, TA (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Mailstop E-02,1600 Clifton Rd, Atlanta, GA 30333 USA. EM tapl@cdc.gov NR 24 TC 8 Z9 8 U1 2 U2 4 PU ROYAL SOC MEDICINE PRESS LTD PI LONDON PA 1 WIMPOLE STREET, LONDON W1G 0AE, ENGLAND SN 0956-4624 J9 INT J STD AIDS JI Int. J. STD AIDS PD JAN PY 2009 VL 20 IS 1 BP 9 EP 13 DI 10.1258/ijsa.2008.008177 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 401SN UT WOS:000262962500003 PM 19103885 ER PT J AU Marum, L Bennett, E Hightower, A Chen, R Kaiser, R Okello, D Mermin, J Sharif, SK AF Marum, L. Bennett, E. Hightower, A. Chen, R. Kaiser, R. Okello, D. Mermin, J. Sharif, S. K. TI The role of health care in the spread of HIV/AIDS in Africa: evidence from Kenya SO INTERNATIONAL JOURNAL OF STD & AIDS LA English DT Letter ID TRANSMISSION C1 [Marum, L.; Bennett, E.; Hightower, A.; Chen, R.; Kaiser, R.; Mermin, J.] Ctr Dis Control & Prevent, NCHHSTP, Global AIDS Program, Atlanta, GA 30333 USA. RP Marum, L (reprint author), CDC, Global AIDS Program, Allanta, GA USA. EM LMarum@cdc.gov; EBenneft@cdc.gov RI Mermin, Jonathan/J-9847-2012 NR 7 TC 2 Z9 2 U1 0 U2 0 PU ROYAL SOC MEDICINE PRESS LTD PI LONDON PA 1 WIMPOLE STREET, LONDON W1G 0AE, ENGLAND SN 0956-4624 J9 INT J STD AIDS JI Int. J. STD AIDS PD JAN PY 2009 VL 20 IS 1 BP 69 EP 70 DI 10.1258/ijsa.2008.008343 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 401SN UT WOS:000262962500023 PM 19103905 ER PT J AU Umeki, K Hisada, M Maloney, EM Hanchard, B Okayama, A AF Umeki, Kazumi Hisada, Michie Maloney, Elizabeth M. Hanchard, Barrie Okayama, Akihiko TI Proviral Loads and Clonal Expansion of HTLV-1-Infected Cells following Vertical Transmission: A 10-Year Follow-Up of Children in Jamaica SO INTERVIROLOGY LA English DT Article DE HTLV-1 infection; Clonal expansion, infected cells; Transmission, vertical ID VIRUS TYPE-I; TROPICAL SPASTIC PARAPARESIS; INFECTIVE DERMATITIS; LEUKEMIA-VIRUS; LEUKEMIA/LYMPHOMA; MYELOPATHY; HTLV-1; SEROCONVERTERS; INTEGRATION; CARRIERS AB Objective: Few studies have specifically examined proviral load (PVL) and clonal evolution of human T-lymphotropic virus type 1 (HTLV-1)-infected cells in vertically infected children. Methods: Sequential samples (from ages 1 to 16 years) from 3 HTLV-1-infected children (cases A, B and C) in the Jamaica Mother Infant Cohort Study were analyzed for their PVL and clonal expansion of HTLV-1- infected cells in peripheral blood mononuclear cells (PBMCs) by inverse-long PCR. Results: The baseline PVL (per 100,000 PBMCs) of case A was 260 (at 1 year of age) and of case B it was 1,867 (at 3 years of age), and they remained constant for more than 10 years. Stochastic patterns of clonal expansion of HTLV-1-infected cells were predominately detected. In contrast, case C, who had lymphadenopathy, seborrheic dermatitis and hyperreflexia, showed an increase in PVL from 2,819 at 1.9 years to 13,358 at 13 years of age, and expansion of 2 dominant clones. Conclusion: The clonal expansion of HTLV-1-infected cells is induced in early childhood after infection acquired from their mothers. Youths with high PVL and any signs and symptoms associated with HTLV-1 infection should be closely monitored. Copyright (C) 2009 S. Karger AG, Basel C1 [Okayama, Akihiko] Miyazaki Univ, Dept Rheumatol Infect Dis & Lab Med, Fac Med, Miyazaki 8891692, Japan. [Hisada, Michie] NCI, Div Canc Epidemiol & Genet, Rockville, MD USA. [Maloney, Elizabeth M.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Hanchard, Barrie] Univ W Indies, Dept Pathol, Mona, Jamaica. RP Okayama, A (reprint author), Miyazaki Univ, Dept Rheumatol Infect Dis & Lab Med, Fac Med, 5200 Kihara, Miyazaki 8891692, Japan. EM okayama@med.miyazaki-u.ac.jp FU Japanese Ministry of Education, Science, Sports and Culture; Miyazaki Prefecture Collaboration of Regional Entities for the Advancement of Technological Excellence (JST); Jamaica Mother Infant Cohort Study; Intramural Research Program of the NIH; National Cancer Institute; Division of Cancer Epidemiology and Genetics FX W e thank Mrs. Beverley Granston for her contribution to the study conduct. This study was supported in part by a grant- in- aid from the Japanese Ministry of Education, Science, Sports and Culture, and the Miyazaki Prefecture Collaboration of Regional Entities for the Advancement of Technological Excellence (JST). The Jamaica Mother Infant Cohort Study was supported by the Intramural Research Program of the NIH, National Cancer Institute, Division of Cancer Epidemiology and Genetics. NR 29 TC 10 Z9 10 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0300-5526 J9 INTERVIROLOGY JI Intervirology PY 2009 VL 52 IS 3 BP 115 EP 122 DI 10.1159/000219384 PG 8 WC Virology SC Virology GA 456WT UT WOS:000266883600001 PM 19468234 ER PT J AU McDonald, JA Manlove, J Ikramullah, EN AF McDonald, Jill A. Manlove, Jennifer Ikramullah, Erum N. TI Immigration Measures and Reproductive Health Among Hispanic Youth: Findings from the National Longitudinal Survey of Youth, 1997-2003 SO JOURNAL OF ADOLESCENT HEALTH LA English DT Article DE Reproductive health; Hispanic; Adolescent pregnancy; Epidemiology; Disparities; Immigration; Acculturation; Language; Mexican-American; Gender ID UNITED-STATES; LATINO ADOLESCENTS; SEXUAL-BEHAVIOR; PUERTO-RICAN; MEXICAN-AMERICAN; ACCULTURATION; WOMEN; CHILDBEARING; ORIENTATION; ONSET AB Purpose: To explore relationships between immigration measures and risk of reproductive and sexual events among U.S. Hispanic adolescents. Methods: We examined generation status, language in the home and country of origin in relation to sexual activity, contraception, and childbearing among 1614 Hispanic adolescents, using nationally representative 1997-2003 longitudinal data. Multivariable analyses controlled for potentially confounding variables. Tests for effect modification by gender and Mexican origin were conducted. Results: Fewer first generation adolescents transitioned to sexual intercourse before age 18 (odds ratio [OR] = .80, 95% confidence interval [CI] = .66-.98) and fewer first and second generation sexually active teens used contraceptives consistently at age 17 (OR = .32, 95% CI = .17-60 and OR = .50, 95% CI = .31-80, respectively) than third-generation teens. Language was similarly associated with the transition to sexual intercourse and contraceptive practices. Versus teens of Mexican origin, teens of Puerto Rican origin and origins other than Cuba and Central/South America had greater odds of becoming sexually active; youth of all origins except Central/South America had fewer multiple live births (OR = .14-31). Gender modified the effects of generation on consistent use of contraceptives and condoms at age 17. Gender also modified the effect of country of origin on transitioning to sexual intercourse before age 18 years. Conclusions: Results expand on previous observations that generation, language, and country of origin are predictors of reproductive and sexual risks for Hispanic adolescents. These immigration measures may therefore be useful in targeting community and clinical preventive services. (c) 2009 Society for Adolescent Medicine. All rights reserved. C1 [McDonald, Jill A.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, Atlanta, GA USA. [Manlove, Jennifer; Ikramullah, Erum N.] Child Trends, Washington, DC USA. RP McDonald, JA (reprint author), 4770 Buford HWY NE,MS K-22, Atlanta, GA 30341 USA. EM ezm5@cdc.gov FU Centers for Disease Control and Prevention on Maternal, Infant and Reproductive Health; National and State Coalition Capacity Building FX Partial funding for this paper was provided through a research grant from the Centers for Disease Control and Prevention on Maternal, Infant and Reproductive Health: National and State Coalition Capacity Building. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. The authors thank Len Paulozzi, M.D., for helpful review of the manuscript. NR 39 TC 26 Z9 26 U1 1 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD JAN PY 2009 VL 44 IS 1 BP 14 EP 24 DI 10.1016/j.jadohealth.2008.08.001 PG 11 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA 388GF UT WOS:000262007600005 PM 19101454 ER PT J AU Kotowski, SE Davis, KG Waters, TR AF Kotowski, Susan E. Davis, Kermit G. Waters, Thomas R. TI Investigation of Select Ergonomic Interventions for Farm Youth. Part 1: Shovels SO JOURNAL OF AGROMEDICINE LA English DT Article DE Farm youth; interventions; manual material handling; musculoskeletal disorders; shoveling AB There is some evidence that performing farm chores may place youth at risk of musculoskeletal injuries. However, actual investigations of interventions for farm youth have been sparse. The objective of the current study was to investigate two different types of interventions (add-on handles) for shovels, potentially reducing the risk of injury in farm youth. A lumbar motion monitor was used to capture trunk posture and motion while the youth performed a simulated shoveling task-removal of material from an animal stall. Ratings of perceived exertion and comfort of use were also assessed. The results indicate add-on handles decreased sagittal flexion but increased twisting as compared to regular shovels. Perceived ratings were worse for shovels with add-on handles. Overall, there appears to be a trade-off between sagittal and nonsagittal motion and appears to have minimal impact on risk of low back injury. However, further research is necessary to determine the complete ramifications of this trade-off with respect to the biomechanical load within the low back and on other joints. C1 [Kotowski, Susan E.; Davis, Kermit G.] Univ Cincinnati, Low Back Biomech & Workplace Stress Lab, Dept Environm Hlth, Cincinnati, OH 45267 USA. [Waters, Thomas R.] NIOSH, Div Appl Res & Technol, Cincinnati, OH 45226 USA. RP Davis, KG (reprint author), Univ Cincinnati, Low Back Biomech & Workplace Stress Lab, Dept Environm Hlth, Cincinnati, OH 45267 USA. EM kermit.davis@uc.edu FU National Institute for Occupational Safety and Health FX This research was made possible by a contract from the National Institute for Occupational Safety and Health. The authors would also like to thank Matt Hammer, Chunhui He, Balaji Sharma, and Qiang Zheng for their assistance in data collection. The findings and conclusions in this paper are those of the authors and do not necessarily represent the views of the National Institute for Occupational Safety and Health. NR 26 TC 7 Z9 7 U1 0 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1059-924X J9 J AGROMEDICINE JI J. Agromedicine PY 2009 VL 14 IS 1 BP 33 EP 43 DI 10.1080/10599240802612604 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA V21QO UT WOS:000208222300006 PM 19214854 ER PT J AU Kotowski, SE Davis, KG Waters, TR AF Kotowski, Susan E. Davis, Kermit G. Waters, Thomas R. TI Investigation of Select Ergonomic Interventions for Farm Youth. Part 2: Wheelbarrows SO JOURNAL OF AGROMEDICINE LA English DT Article DE Farm youth; interventions; manual material handling; musculoskeletal disorders; wheelbarrow AB Previous research has provided evidence that farm youth performing farm chores may be at risk of developing a low back musculoskeletal injury. In order to reduce these risks, effective interventions for reducing the stressors that cause the injuries are needed. The objective of the current study was to investigate alternative wheelbarrow styles as an intervention for youth working to transfer material on the farm with respect to trunk motion and perceived exertion. A lumbar motion monitor was used to capture three-dimensional trunk kinematics while several wheelbarrow tasks (e.g., pushing, pushing over bump, and dumping) were performed by youth. Ratings of perceived exertion and comfort of use were also assessed. Results indicated a reduction in the sagittal trunk flexion and velocity was achieved by adding a push bar to the handles, in combination with three-wheels, or utilizing adjustable handles. However, these alterations had little impact in the predicted low back disorder risk levels. Additionally, the youths' perceptions of risk and exertion levels were greater for these alternative wheelbarrows than for the regular wheelbarrow. Therefore, the mismatch between perception and kinematic response will probably affect usage of the alternative wheelbarrows. While the results indicate that alternative wheelbarrow designs can reduce the awkward postures and motions during wheelbarrow tasks, further research into the effectiveness of these interventions, including spine loading and long long-term use, is necessary. C1 [Kotowski, Susan E.; Davis, Kermit G.] Univ Cincinnati, Low Back Biomech & Workplace Stress Lab, Dept Environm Hlth, Cincinnati, OH 45267 USA. [Waters, Thomas R.] NIOSH, Div Appl Res & Technol, Cincinnati, OH 45226 USA. RP Davis, KG (reprint author), Univ Cincinnati, Low Back Biomech & Workplace Stress Lab, Dept Environm Hlth, Cincinnati, OH 45267 USA. EM kermit.davis@uc.edu FU National Institute for Occupational Safety and Health FX This research was made possible by a contract from the National Institute for Occupational Safety and Health. The authors would also like to thank Matt Hammer, Chunhui He, Balaji Sharma, and Qiang Zheng for their assistance in data collection. The findings and conclusions in this paper are those of the authors and do not necessarily represent the views of the National Institute for Occupational Safety and Health. NR 11 TC 6 Z9 6 U1 0 U2 6 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1059-924X J9 J AGROMEDICINE JI J. Agromedicine PY 2009 VL 14 IS 1 BP 44 EP 57 DI 10.1080/10599240802612653 PG 14 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA V21QO UT WOS:000208222300007 PM 19214855 ER PT J AU Miller, EK Edwards, KM Weinberg, GA Lwane, MK Griffin, MR Hall, CB Zhu, YW Szilagyi, PG Morin, LL Heil, LH Lu, XY Williams, JV AF Miller, E. Kathryn Edwards, Kathryn M. Weinberg, Geoffrey A. Lwane, Marika K. Griffin, Marie R. Hall, Caroline B. Zhu, Yuwei Szilagyi, Peter G. Morin, Laura-Lee Heil, Luke H. Lu, Xiaoyan Williams, John V. CA New Vaccine Surveillance Network TI A novel group of rhinoviruses is associated with asthma hospitalizations SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Article DE Human rhinoviruses; asthma; children; wheezing; hospitalized; genetic diversity ID RESPIRATORY-TRACT INFECTIONS; POLYMERASE-CHAIN-REACTION; TRANSCRIPTION-PCR ASSAY; YOUNG-CHILDREN; HUMAN METAPNEUMOVIRUS; SYNCYTIAL VIRUS; ILLNESS; EXACERBATIONS; EPIDEMIC; ENTEROVIRUS-68 AB Background: Although recent studies have identified new group C human rhinoviruses (HRVCs), their spectrum of pediatric disease is unknown. Objective: We sought to determine the presentation and burden of disease caused by HRVCs among young hospitalized children. Methods: We conducted prospective population-based surveillance in 2 US counties among children less than 5 years of age hospitalized with acute respiratory illness or fever from October 2001 through September 2003. Nasal/throat swabs were obtained and tested for HRVs, as determined by means of RT-PCR and then characterized by means of partial sequencing. Results: Of 1052 children enrolled and tested during the 2-year period, 167 (16%) had HRVs detected. Of 147 samples successfully sequenced, 64 were group A HRVs, 6 were group B HRVs, and 77 were HRVCs. Children with HRVCs were significantly more likely than those with group A HRVs to have underlying high-risk conditions, such as asthma (42% vs 23%, P = .023) and to have had a discharge diagnosis of asthma (55% vs 36%, P = .022). Conclusions: Overall, HRVCs were detected in 7% of children hospitalized for fever or respiratory conditions and constituted almost half of all rhinovirus-associated hospitalizations, suggesting that this novel group causes a substantial burden of pediatric disease. (J Allergy Clin Immunol 2009;123:98-104.) C1 [Lwane, Marika K.; Lu, Xiaoyan] Ctr Dis Control & Prevent, Natl Immunizat Program, Resp & Enter Viruses Branch, Atlanta, GA USA. [Weinberg, Geoffrey A.; Hall, Caroline B.; Szilagyi, Peter G.] Univ Rochester, Sch Med & Dent, Dept Pediat, Rochester, NY 14627 USA. [Miller, E. Kathryn; Edwards, Kathryn M.; Morin, Laura-Lee; Heil, Luke H.; Williams, John V.] Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN 37232 USA. [Williams, John V.] Vanderbilt Univ, Med Ctr, Dept Microbiol & Immunol, Nashville, TN 37232 USA. [Zhu, Yuwei] Vanderbilt Univ, Med Ctr, Dept Biostat, Nashville, TN 37232 USA. [Griffin, Marie R.] Vanderbilt Univ, Med Ctr, Dept Prevent Med, Nashville, TN 37232 USA. RP Miller, EK (reprint author), Vanderbilt Childrens Hosp, 2200 Childrens Way,11215 Doctors Off Tower, Nashville, TN 37232 USA. EM eva.k.miller@vanderbilt.edu RI Williams, John/F-6962-2010 OI Williams, John/0000-0001-8377-5175 FU Centers for Disease Control and Prevention [U38/CCU417958, U01/IP000022, U38/CCU217969, U01/IP000017]; MedImmune; Agency for Healthcare Quality and Research [T32 HS 13833-02] FX This project was supported in part by cooperative agreement nos. U38/CCU417958, U01/IP000022, U38/CCU217969, and U01/IP000017 from the Centers for Disease Control and Prevention, by MedImmune (provided funding for PCR and DNA sequencing supplies to EKM), and by the Agency for Healthcare Quality and Research (T32 HS 13833-02 to EKM). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the Centers for Disease Control and Prevention. NR 56 TC 144 Z9 151 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD JAN PY 2009 VL 123 IS 1 BP 98 EP 104 DI 10.1016/j.jaci.2008.10.007 PG 7 WC Allergy; Immunology SC Allergy; Immunology GA 399IP UT WOS:000262793900015 PM 19027147 ER PT J AU Johnson, RC Zhou, Y Statler, K Thomas, J Cox, F Hall, S Barr, JR AF Johnson, Rudolph C. Zhou, Yingtao Statler, Kristen Thomas, Jerry Cox, Frederick Hall, Sherwood Barr, John R. TI Quantification of Saxitoxin and Neosaxitoxin in Human Urine Utilizing Isotope Dilution Tandem Mass Spectrometry SO JOURNAL OF ANALYTICAL TOXICOLOGY LA English DT Article ID PARALYTIC SHELLFISH POISON; ELECTROSPRAY IONIZATION; CYANOBACTERIAL TOXINS; POSTMORTEM ANALYSIS; IDENTIFICATION; ELIMINATION; SAMPLES; TISSUE; RAT C1 [Johnson, Rudolph C.; Zhou, Yingtao; Statler, Kristen; Thomas, Jerry; Barr, John R.] Ctr Dis Control & Prevent, Div Sci Lab, Atlanta, GA 30341 USA. [Cox, Frederick] Battelle Eastern Sci & Technol Ctr, Aberdeen, MD 21001 USA. [Hall, Sherwood] US FDA, Off Regulatory Sci HFS 716, Ctr Food Safety & Appl Nutr, College Pk, MD 20740 USA. RP Johnson, RC (reprint author), Ctr Dis Control & Prevent, Div Sci Lab, 4770 Buford Highway,MS F44, Atlanta, GA 30341 USA. NR 32 TC 17 Z9 18 U1 1 U2 8 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0146-4760 EI 1945-2403 J9 J ANAL TOXICOL JI J. Anal. Toxicol. PD JAN-FEB PY 2009 VL 33 IS 1 BP 8 EP 14 PG 7 WC Chemistry, Analytical; Toxicology SC Chemistry; Toxicology GA 400OD UT WOS:000262876800002 PM 19161664 ER PT J AU Hickson, DA Wilhite, RL Petrini, MF White, WB Burchfiel, C AF Hickson, DeMarc A. Wilhite, Rachel L. Petrini, Marcy F. White, Wendy B. Burchfiel, Cecil TI Asthma and Asthma Severity among African American Adults in the Jackson Heart Study SO JOURNAL OF ASTHMA LA English DT Article DE African Americans; asthma; asthma severity; Jackson Heart Study; wheezing ID OBSTRUCTIVE PULMONARY-DISEASE; SPIROMETRIC REFERENCE VALUES; CARDIOVASCULAR-DISEASE; ATHEROSCLEROSIS RISK; SEX-DIFFERENCES; LUNG-FUNCTION; US ADULTS; PREVALENCE; DISPARITIES; RACE AB The aims of this study were to investigate the baseline prevalence of and risk factors associated with asthma, classify asthma severity, and describe medication use in a population-based sample of African American men and women 21 to 84 years of age from the Jackson Heart Study (JHS). Participants provided responses to respiratory and medical history questions and a medication inventory and underwent spirometry and other clinical examinations. These data were used to examine the extent to which novel and traditional risk factors were associated with asthma. Of the 4,098 participants included in this analysis, 9.4% reported lifetime asthma (5.7% current, 3.7% former), and current asthma was higher in women (6.8%) than in men (3.8%). An additional 9.8% reported an attack of wheeze with shortness of breath or non-doctor confirmed asthma (i.e., probable asthma). The mean forced expiratory volume in 1 second (FEV1)% predicted was lower in those reporting current asthma (women: 83.7 18.0; men: 75.2 16.8) compared to those not reporting asthma (women: 95.6 16.7; men: 91.7 16.0). Current and probable asthma was associated with lower serum cortisol levels and hypertension medication use, along with traditional risk factors (i.e., lower socio-economic status, higher global stress scores, obesity, and fair to poor perceived general health). Severe asthma was low among participants reporting current (9.8%), former (3.3%), and probable (4.9%) asthma. Asthma medication use was reported by nearly 60% of the participants reporting current asthma. Asthma in African American adults is associated with decreased serum cortisol, hypertension medication use, and considerable lung function impairment compared to those who did not report asthma. The prevalence of asthma in the JHS is lower than state and national estimates, although the estimates are not directly comparable. Furthermore, asthma is drastically underdiagnosed in this population. C1 [Hickson, DeMarc A.] Jackson State Univ, Coordinating Ctr, Jackson Heart Study, Jackson, MS USA. [Hickson, DeMarc A.; Wilhite, Rachel L.] Univ Mississippi, Med Ctr, Jackson Heart Study, Examinat Ctr, University, MS 38677 USA. [Wilhite, Rachel L.] Univ Arizona, Zuckermann Coll Publ Hlth, Dept Epidemiol, Tucson, AZ 85721 USA. [Petrini, Marcy F.] Univ Mississippi, Med Ctr, Div Pulm & Crit Care & Sleep Med, University, MS 38677 USA. [White, Wendy B.] Tougaloo Coll, Jackson Heart Study, Undergrad Training Ctr, Tougaloo, MS USA. [Burchfiel, Cecil] NIOSH, Ctr Dis Control & Prevent, Hlth Effects Lab Div, Atlanta, GA USA. RP Hickson, DA (reprint author), 350 W Woodrow Wilson Ave,Suite 701, Jackson, MS 39213 USA. FU NIH [N01-HC95170, N01-HC-95171, N01-HC-95172]; National Heart, Lung, and Blood Institute; National Center for Minority Health and Health Disparities; National Institute of Biomedical Imaging and Bioengineering; National Institutes of Health (NIH); National Institute for Occupational Safety and Health (NIOSH) FX The authors would like to thank the participants, staff, and interns of the Jackson Heart Study for their long-term commitment to the study. The authors also thank Drs. Doug Campbell and Stefano Guerra for their careful review and classification of the asthma medications and Dr. Sharon B. Wyatt for her critical review of the manuscript. The Jackson Heart Study is supported by NIH contracts N01-HC95170, N01-HC-95171 and N01-HC-95172 that are provided by the National Heart, Lung, and Blood Institute, the National Center for Minority Health and Health Disparities, and the National Institute of Biomedical Imaging and Bioengineering. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institutes of Health (NIH) or the National Institute for Occupational Safety and Health (NIOSH). NR 46 TC 5 Z9 5 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0277-0903 J9 J ASTHMA JI J. Asthma PY 2009 VL 46 IS 4 BP 421 EP 428 AR PII 911835318 DI 10.1080/02770900902846307 PG 8 WC Allergy; Respiratory System SC Allergy; Respiratory System GA 451RZ UT WOS:000266489100020 PM 19484681 ER PT J AU Atherly, A Nurmagambetov, T Williams, S Griffith, M AF Atherly, Adam Nurmagambetov, Tursynbek Williams, Seymour Griffith, Marcia TI An Economic Evaluation of the School-Based oPower Breathingo Asthma Program SO JOURNAL OF ASTHMA LA English DT Article DE asthma; school intervention; adolescents; economic evaluation AB This study evaluated the cost effectiveness of the oPower Breathingo program for asthma among middle and high school students. Few systematic evaluations of school based interventionslet alone cost-effectiveness programshave been identified in the literature. Power Breathing was developed by the Asthma and Allergy Foundation of America and is currently available for implementation by school districts. For the overall evaluation, 8 junior high schools and 2 high schools were selected and matched based on grade range, enrollment, income and race/ethnicity. Schools were randomly assigned to the intervention or control group. Surveys were administered at baseline, immediately post-intervention and 3 months' post-intervention. Children in the intervention arm had a significant decrease in the number of days they experienced an asthma attack or had trouble breathing during a 2-week period of 0.18 days per 2 weeks. In contrast, subjects in the control group had an increase in the in the number of days experiencing an asthma attack or having trouble breathing during a 2-week period of 0.102, from 0.696 to 0.793. The program cost approximately $3.9 per asthma attack-free day gained, on par with pharmaceutical interventions, suggesting that Power Breathing may be a cost effective asthma intervention. The results of this study suggest that school-based interventions aimed at asthma, properly implemented and administrated, are an appropriate use of societal resources. C1 [Atherly, Adam] Emory Univ, Atlanta, GA 30322 USA. [Nurmagambetov, Tursynbek; Griffith, Marcia] Ctr Dis Control, Air Pollut & Resp Hlth Branch, Atlanta, GA 30333 USA. [Williams, Seymour] Ctr Dis Control, HIV AIDS Care & Treatment Branch, Atlanta, GA 30333 USA. RP Atherly, A (reprint author), Emory Univ, 1518 Clifton Rd NE, Atlanta, GA 30322 USA. EM aatherl@sph.emory.edu NR 12 TC 1 Z9 1 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0277-0903 J9 J ASTHMA JI J. Asthma PY 2009 VL 46 IS 6 BP 596 EP 599 AR PII 913557366 DI 10.1080/02770900903006257 PG 4 WC Allergy; Respiratory System SC Allergy; Respiratory System GA 480BV UT WOS:000268707700012 PM 19657901 ER PT J AU Morrison, T Callahan, D Moorman, J Bailey, C AF Morrison, Teresa Callahan, David Moorman, Jeanne Bailey, Cathy TI A National Survey of Adult Asthma Prevalence by Urban-Rural Residence US 2005 SO JOURNAL OF ASTHMA LA English DT Article DE asthma; urban population; rural population; Behavioral Risk Factor Surveillance System; urban influence codes ID FARMING ENVIRONMENTS; CHILDHOOD ASTHMA; INNER-CITY; CHILDREN; ALLERGY; POPULATIONS; EXPOSURES; SYMPTOMS; DISEASE; ECZEMA AB Objectives. We analyzed national data to estimate asthma prevalence among U. S. adults by urban-rural residence and to determine the relative contributions of sociodemographic and health behavior characteristics on the probability of reporting asthma. Methods. We linked the 2005 Behavioral Risk Factor Surveillance System (BRFSS) to Urban Influence Codes (UICs), categorizing respondents into four urban-rural groups: metropolitan, adjacent metropolitan, micropolitan, and remote. BRFSS collects health data from all 50 states. UICs classify respondent's county as urban or rural based on population size and proximity to metropolitan areas. We calculated asthma prevalence estimates and generated odds ratios (ORs) for the probability of reporting asthma. Results. Overall asthma prevalence (7.9%; 95% CI = 7.73-8.08) was not statistically different (p = 0.28) by urban-rural residence. After adjusting for selected characteristics, adjacent metropolitan (OR = 0.96; 95% CI = 0.90-1.02) and remote (OR = 0.95; 95% CI = 0.85-1.05) residents were less likely-and micropolitan (OR = 1.04; 95% CI = 0.93-1.16) residents were more likely-to report asthma compared with metropolitan residents; but confidence intervals included null. Conclusions. Asthma prevalence is as high in rural as in urban areas. Certain demographic, behavioral, and health care characteristics unique to place of residence might affect asthma prevalence. Because these results substantially change our understanding of asthma prevalence in rural areas, further investigation is needed to determine geographic-related risk factors C1 [Morrison, Teresa; Callahan, David; Moorman, Jeanne; Bailey, Cathy] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. RP Morrison, T (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, 4770 Buford Highway NE,MS F-58, Atlanta, GA 30341 USA. EM TAMorrison@cdc.gov NR 47 TC 14 Z9 14 U1 0 U2 4 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0277-0903 J9 J ASTHMA JI J. Asthma PY 2009 VL 46 IS 8 BP 751 EP 758 DI 10.3109/02770900903144686 PG 8 WC Allergy; Respiratory System SC Allergy; Respiratory System GA 521JU UT WOS:000271918300001 PM 19863276 ER PT J AU Hootman, JM AF Hootman, Jennifer M. TI 2008 Physical Activity Guidelines for Americans: An Opportunity for Athletic Trainers SO JOURNAL OF ATHLETIC TRAINING LA English DT Editorial Material C1 CDC, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. RP Hootman, JM (reprint author), CDC, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. NR 6 TC 8 Z9 9 U1 0 U2 3 PU NATL ATHLETIC TRAINERS ASSOC INC PI DALLAS PA 2952 STEMMONS FREEWAY, DALLAS, TX 75247 USA SN 1062-6050 J9 J ATHL TRAINING JI J. Athl. Train. PD JAN-FEB PY 2009 VL 44 IS 1 BP 5 EP 6 DI 10.4085/1062-6050-44.1.5 PG 2 WC Sport Sciences SC Sport Sciences GA 402JV UT WOS:000263010900001 PM 19180212 ER PT J AU Kuklenyik, Z Ye, XY Needham, LL Calafat, AM AF Kuklenyik, Zsuzsanna Ye, Xiaoyun Needham, Larry L. Calafat, Antonia M. TI Automated Solid-Phase Extraction Approaches for Large Scale Biomonitoring Studies SO JOURNAL OF CHROMATOGRAPHIC SCIENCE LA English DT Article ID TANDEM MASS-SPECTROMETRY; PERFLUORINATED ORGANIC-ACIDS; HUMAN EXPOSURE ASSESSMENT; LIQUID-CHROMATOGRAPHY; PHTHALATE METABOLITES; HUMAN URINE; HUMAN SERUM; PERFLUOROOCTANE SULFONATE; ENVIRONMENTAL PHENOLS; GENERAL-POPULATION C1 [Kuklenyik, Zsuzsanna; Ye, Xiaoyun; Needham, Larry L.; Calafat, Antonia M.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. RP Kuklenyik, Z (reprint author), Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. EM ZKuklenyik@cdc.gov RI Needham, Larry/E-4930-2011 NR 43 TC 17 Z9 17 U1 2 U2 14 PU PRESTON PUBL INC PI NILES PA 7800 MERRIMAC AVE PO BOX 48312, NILES, IL 60648 USA SN 0021-9665 J9 J CHROMATOGR SCI JI J. Chromatogr. Sci. PD JAN PY 2009 VL 47 IS 1 BP 12 EP 18 PG 7 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 392KN UT WOS:000262301700003 PM 19161651 ER PT J AU Miller, S Gorman-Smith, D Sullivan, T Orpinas, P Simon, TR AF Miller, Shari Gorman-Smith, Deborah Sullivan, Terri Orpinas, Pamela Simon, Thomas R. TI Parent and Peer Predictors of Physical Dating Violence Perpetration in Early Adolescence: Tests of Moderation and Gender Differences SO JOURNAL OF CLINICAL CHILD AND ADOLESCENT PSYCHOLOGY LA English DT Article ID ROMANTIC RELATIONSHIPS; DRUG-USE; PREVENTION PROGRAM; SUBSTANCE USE; SAFE DATES; DELINQUENT BEHAVIORS; AGGRESSIVE-BEHAVIOR; URBAN ADOLESCENTS; PARTNER VIOLENCE; FAMILY VIOLENCE AB This study examined parenting and peer predictors of physical dating violence perpetration during early adolescence and tested moderation among these predictors and gender. Participants were 2,824 ethnically diverse sixth-grade students with a recent boyfriend/girlfriend who was part of a multisite, longitudinal investigation of the development and prevention of violence among middle school students. Those students who reported having a boyfriend/girlfriend reported significantly more drug use and delinquent activity and were more likely to be male. Twenty-nine percent of youth with a boyfriend/girlfriend reported perpetrating physical aggression against their boyfriend/girlfriend. Parenting and peer variables were significant predictors of physical dating violence. However, gender moderated the association between parenting practices and physical dating violence, with parental monitoring inversely linked to dating violence for boys and parent support for nonaggression inversely linked to dating violence for girls. Parent support for aggression also moderated the association between peer deviancy and reported perpetration. Finally, gender moderated the interaction between peer deviancy and parent support for nonaggressive solutions. C1 [Miller, Shari] RTI Int, Crime Violence & Justice Res Program, Res Triangle Pk, NC 27709 USA. [Gorman-Smith, Deborah] Univ Chicago, Inst Juvenile Res, Chicago, IL 60637 USA. [Sullivan, Terri] Virginia Commonwealth Univ, Dept Psychol, Richmond, VA 23284 USA. [Orpinas, Pamela] Univ Georgia, Athens, GA 30602 USA. [Simon, Thomas R.] Ctr Dis Control, Div Violence Prevent, Atlanta, GA 30333 USA. RP Miller, S (reprint author), RTI Int, Crime Violence & Justice Res Program, 3040 Cornwallis Dr, Res Triangle Pk, NC 27709 USA. EM shari@rti.org RI Price, Katie/H-1931-2012 FU NIMH NIH HHS [K01 MH067975, K01 MH67975]; PHS HHS [U81/CCU317633, U81/CCU417759, U81/CCU417778, U81/CCU517816] NR 85 TC 32 Z9 34 U1 2 U2 14 PU LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS PI PHILADELPHIA PA 325 CHESTNUT STREET, STE 800, PHILADELPHIA, PA 19106 USA SN 1537-4416 J9 J CLIN CHILD ADOLESC JI J. Clin. Child Adolesc. Psychol. PY 2009 VL 38 IS 4 BP 538 EP 550 DI 10.1080/15374410902976270 PG 13 WC Psychology, Clinical; Psychology, Developmental SC Psychology GA 481CQ UT WOS:000268785000008 PM 20183640 ER PT J AU Hendriksen, RS Seyfarth, AM Jensen, AB Whichard, J Karlsmose, S Joyce, K Mikoleit, M Delong, SM Weill, FX Aidara-Kane, A Wong, DMALF Angulo, FJ Wegener, HC Aarestrup, FM AF Hendriksen, Rene S. Seyfarth, Anne Mette Jensen, Arne B. Whichard, Jean Karlsmose, Susanne Joyce, Kevin Mikoleit, Matthew Delong, Stephanie M. Weill, Francois-Xavier Aidara-Kane, Awa Wong, Danilo M. A. Lo Fo Angulo, Frederick J. Wegener, Henrik C. Aarestrup, Frank M. TI Results of Use of WHO Global Salm-Surv External Quality Assurance System for Antimicrobial Susceptibility Testing of Salmonella Isolates from 2000 to 2007 SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article AB An international External Quality Assurance System (EQAS) for antimicrobial susceptibility testing of Salmonella was initiated in 2000 by the World Health Organization (WHO) Global Salm-Surv in order to enhance the capacities of national reference laboratories to obtain reliable data for surveillance purposes worldwide. Seven EQAS iterations have been conducted from 2000 to 2007. In each iteration, participating laboratories submitted susceptibility results from 10 to 15 antimicrobial agents for eight Salmonella isolates and an Escherichia coli reference strain (ATCC 25922). A total of 287 laboratories in 102 countries participated in at least one EQAS iteration. A large number of laboratories reported results for the E. coli ATCC 25922 reference strain which were outside the quality control ranges. Critical deviations for susceptibility testing of the Salmonella isolates varied from 4% in 2000 to 3% in 2007. Consistent difficulties were observed in susceptibility testing of amoxicillin-clavulanic acid, cefotaxime, ceftazidime, streptomycin, sulfonamides, and tetracycline. Regional variations in performance were observed, with laboratories in central Asia, Africa, and the Middle East not performing as well as those in other regions. Results from the WHO Global Salm-Surv EQAS show that most laboratories worldwide are capable of correctly performing antimicrobial susceptibility testing of Salmonella isolates, but they also indicate that further improvement for some laboratories is needed. In particular, further training and dissemination of information on quality control, appropriate interpretive criteria (breakpoints), and harmonization of the methodology worldwide through WHO Global Salm-Surv and other programs will contribute to the generation of comparable and reliable antimicrobial susceptibility data (D. M. A. Lo Fo Wong, R. S. Hendriksen, D. J. Mevius, K. T. Veldman, and F. M. Aarestrup, Vet. Microbiol. 115: 128-139, 2006). C1 [Hendriksen, Rene S.; Seyfarth, Anne Mette; Jensen, Arne B.; Karlsmose, Susanne; Wegener, Henrik C.; Aarestrup, Frank M.] Natl Food Inst, WHO Collaborating Ctr, Antimicrobial Resistance Foodborne Pathogens & Co, DK-1790 Copenhagen V, Denmark. [Joyce, Kevin; Mikoleit, Matthew; Delong, Stephanie M.; Angulo, Frederick J.] Ctr Dis Control & Prevent, Enter Dis Epidemiol Branch, WHO Collaborating Ctr Surveillance Epidemiol & Co, Atlanta, GA USA. [Weill, Francois-Xavier] Inst Pasteur, WHO Collaborating Ctr Salmonella, Paris, France. [Aidara-Kane, Awa; Wong, Danilo M. A. Lo Fo] WHO, Dept Food Safety Zoonoses & Fooborne Dis, CH-1211 Geneva, Switzerland. RP Hendriksen, RS (reprint author), Natl Food Inst, WHO Collaborating Ctr, Antimicrobial Resistance Foodborne Pathogens & Co, Bulowsvej 27, DK-1790 Copenhagen V, Denmark. EM rshe@food.dtu.dk OI Weill, Francois-Xavier/0000-0001-9941-5799; Mikoleit, Matthew/0000-0002-4582-6733; Wegener, Henrik Caspar/0000-0002-6888-2121 NR 9 TC 10 Z9 11 U1 1 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JAN PY 2009 VL 47 IS 1 BP 79 EP 85 DI 10.1128/JCM.00894-08 PG 7 WC Microbiology SC Microbiology GA 390IR UT WOS:000262158000009 PM 19020068 ER PT J AU Feng, YY Li, N Duan, LP Xiao, LH AF Feng, Yaoyu Li, Na Duan, Liping Xiao, Lihua TI Cryptosporidium Genotype and Subtype Distribution in Raw Wastewater in Shanghai, China: Evidence for Possible Unique Cryptosporidium hominis Transmission SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; MOLECULAR CHARACTERIZATION; UNITED-KINGDOM; NEW-ZEALAND; CHILDREN; SPP.; HUMANS; PARVUM; DIARRHEA; SAMPLES AB To identify the genotype and subtype distributions of Cryptosporidium oocysts in domestic wastewater in Shanghai, China, and to facilitate the characterization of the endemic transmission of cryptosporidiosis, raw domestic wastewater samples were collected from four wastewater treatment plants in Shanghai, China, from December 2006 to April 2007. Genotypes of Cryptosporidium species were detected based on PCR-restriction fragment length polymorphism and sequence analyses of the small-subunit rRNA gene. Samples that contained Cryptosporidium hominis were further subtyped by DNA sequencing of the 60-kDa glycoprotein gene. Among a total of 90 samples analyzed, 63 were PCR positive, 10 of which had mixed genotypes. Fifty-nine (93.7%) of the PCR-positive samples had C. hominis, and 7 (11.1%) had C. meleagridis. The other seven Cryptosporidium species/genotypes identified included C. baileyi, C. parvum, C. suis, C. muris, rat genotype, avian genotype III, and a novel genotype. Forty-seven of the 59 C. hominis-positive samples were successfully subtyped, with 29 having subtype family Ib and the remaining belonging to subtype families Ia, Id, Ie, and If. The three Ib subtypes identified, IbA19G2, IbA20G2, and IbA21G2, were very different from the two common Ib subtypes (IbA9G3 and IbA10G2) found in other areas of the world. Likewise, the Ie subtype IeA12G3T3 was also different from the common IeA11G3T3 subtype. Thus, the presence of multiple subtype families and unique Ib, Ie, and If subtypes indicates that there might be endemic transmission of cryptosporidiosis in the study area and that C. hominis populations there might be very different from those in other areas. C1 [Li, Na; Duan, Liping; Xiao, Lihua] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30341 USA. [Feng, Yaoyu] E China Univ Sci & Technol, Sch Resource & Environm Engn, Shanghai 200237, Peoples R China. [Li, Na; Duan, Liping] Tongji Univ, Sch Life Sci & Technol, Shanghai 200295, Peoples R China. [Li, Na; Duan, Liping] Atlanta Res & Educ Fdn, Decatur, GA 30033 USA. RP Xiao, LH (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Bldg 22,Mail Stop F-12,4770 Buford Highway, Atlanta, GA 30341 USA. EM lxiao@cdc.gov RI Xiao, Lihua/B-1704-2013; Feng, Yaoyu/B-3076-2014 OI Xiao, Lihua/0000-0001-8532-2727; FU U.S. Centers for Disease Control and Prevention; National Natural Science Foundation of China [30771881] FX This study was supported in part by funds from the U.S. Centers for Disease Control and Prevention and the National Natural Science Foundation of China ( grant no. 30771881). NR 55 TC 50 Z9 53 U1 1 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JAN PY 2009 VL 47 IS 1 BP 153 EP 157 DI 10.1128/JCM.01777-08 PG 5 WC Microbiology SC Microbiology GA 390IR UT WOS:000262158000020 PM 19005143 ER PT J AU Mitchell, SL Wolff, BJ Thacker, WL Ciembor, PG Gregory, CR Everett, KDE Ritchie, BW Winchell, JM AF Mitchell, Stephanie L. Wolff, Bernard J. Thacker, W. Lanier Ciembor, Paula G. Gregory, Christopher R. Everett, Karin D. E. Ritchie, Branson W. Winchell, Jonas M. TI Genotyping of Chlamydophila psittaci by Real-Time PCR and High-Resolution Melt Analysis SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID OUTER-MEMBRANE PROTEIN; OMPA GENES; INFECTION; DIFFERENTIATION; PNEUMONIAE; OUTBREAK; HUMANS; BIRDS AB Human infection with Chlamydophila ( Chlamydia) psittaci can lead to psittacosis, a disease that occasionally results in severe pneumonia and other medical complications. C. psittaci is currently grouped into seven avian genotypes: A through F and E/B. Serological testing, outer membrane protein A (ompA) gene sequencing, and restriction fragment length polymorphism analysis are currently used for distinguishing these genotypes. Although accurate, these methods are time-consuming and require multiple confirmatory tests. By targeting the ompA gene, a real-time PCR assay has been developed to rapidly detect and genotype C. psittaci by light-upon-extension chemistry and high-resolution melt analysis. Using this assay, we screened 169 animal specimens; 98 were positive for C. psittaci (71.4% genotype A, 3.1% genotype B, 4.1% genotype E, and 21.4% unable to be typed). This test may provide insight into the distribution of each genotype among specific hosts and provide epidemiological and epizootiological data in human and mammalian/ avian cases. This diagnostic assay may also have veterinary applications during chlamydial outbreaks, particularly with respect to identifying the sources and tracking the movements of a particular genotype when multiple animal facilities are affected. C1 [Mitchell, Stephanie L.; Wolff, Bernard J.; Thacker, W. Lanier; Winchell, Jonas M.] Ctr Dis Control & Prevent, Resp Dis Branch, Atlanta, GA 30333 USA. [Ciembor, Paula G.; Gregory, Christopher R.; Ritchie, Branson W.] Univ Georgia, Coll Vet Med, Infect Dis Lab, Atlanta, GA USA. [Everett, Karin D. E.] Ameritek USA, Everett, WA USA. RP Winchell, JM (reprint author), Ctr Dis Control & Prevent, Resp Dis Branch, Atlanta, GA 30333 USA. EM jwinchell@cdc.gov FU Centers for Disease Control and Prevention, Atlanta, GA; National Animal Disease Center, Ames, IA FX We thank Carolyn Black and Joseph Igietseme of the Centers for Disease Control and Prevention, Atlanta, GA, and also the National Animal Disease Center, Ames, IA, for providing C. psittaci strains used in this study. NR 26 TC 21 Z9 22 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JAN PY 2009 VL 47 IS 1 BP 175 EP 181 DI 10.1128/JCM.01851-08 PG 7 WC Microbiology SC Microbiology GA 390IR UT WOS:000262158000024 PM 19005152 ER PT J AU Abernathy, E Cabezas, C Sun, H Zheng, Q Chen, MH Castillo-Solorzano, C Ortiz, AC Osores, F Oliveira, L Whittembury, A Andrus, JK Helfand, RF Icenogle, J AF Abernathy, Emily Cabezas, Cesar Sun, Hong Zheng, Qi Chen, Min-hsin Castillo-Solorzano, Carlos Ortiz, Ana Cecilia Osores, Fernando Oliveira, Lucia Whittembury, Alvaro Andrus, Jon K. Helfand, Rita F. Icenogle, Joseph TI Confirmation of Rubella within 4 Days of Rash Onset: Comparison of Rubella Virus RNA Detection in Oral Fluid with Immunoglobulin M Detection in Serum or Oral Fluid SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID POLYMERASE-CHAIN-REACTION; REVERSE TRANSCRIPTION; SALIVARY DIAGNOSIS; CLINICAL-SAMPLES; UNITED-KINGDOM; BLOOD SPOTS; SURVEILLANCE; INFECTION; IGM; ASSAY AB Rubella virus infection is typically diagnosed by the identification of rubella virus-specific immunoglobulin M (IgM) antibodies in serum, but approximately 50% of serum samples from rubella cases collected on the day of rash onset are negative for rubella virus-specific IgM. The ability to detect IgM in sera and oral fluids was compared with the ability to detect rubella virus RNA in oral fluids by reverse transcription-PCR (RT-PCR) by using paired samples taken within the first 4 days after rash onset from suspected rubella cases during an outbreak in Peru. Sera were tested for IgM by both indirect and capture enzyme immunoassays (EIAs), and oral fluids were tested for IgM by a capture EIA. Tests for IgM in serum were more sensitive for the confirmation of rubella than the test for IgM in oral fluid during the 4 days after rash onset. RT-PCR confirmed more suspected cases than serum IgM tests on days 1 and 2 after rash onset. The methods confirmed approximately the same number of cases on days 3 and 4 after rash onset. However, a few cases were detected by serum IgM tests but not by RT-PCR even on the day of rash onset. Nine RT-PCR-positive oral fluid specimens were shown to contain rubella virus sequences of genotype 1C. In summary, RT-PCR testing of oral fluid confirmed more rubella cases than IgM testing of either serum or oral fluid samples collected in the first 2 days after rash onset; the maximum number of confirmations of rubella cases was obtained by combining RT-PCR and serology testing. C1 [Abernathy, Emily; Sun, Hong; Zheng, Qi; Chen, Min-hsin; Helfand, Rita F.; Icenogle, Joseph] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Cabezas, Cesar; Ortiz, Ana Cecilia; Osores, Fernando] Minist Salud, Inst Nacl Salud, Lima, Peru. [Castillo-Solorzano, Carlos; Oliveira, Lucia; Andrus, Jon K.] Pan Amer Hlth Org, Washington, DC USA. [Whittembury, Alvaro] Minist Salud, Direcc Gen Epidemiol, Lima, Peru. RP Icenogle, J (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd,Mail Stop C-22, Atlanta, GA 30333 USA. EM jci1@cdc.gov NR 26 TC 33 Z9 34 U1 0 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JAN PY 2009 VL 47 IS 1 BP 182 EP 188 DI 10.1128/JCM.01231-08 PG 7 WC Microbiology SC Microbiology GA 390IR UT WOS:000262158000025 PM 19005151 ER PT J AU Bandea, CI Koumans, EH Sawyer, MK Dover, J O'Connor, A Papp, JR Unger, ER Braxton, J Black, CM AF Bandea, Claudiu I. Koumans, Emilia H. Sawyer, Mary K. Dover, Jason O'Connor, Angelica Papp, John R. Unger, Elizabeth R. Braxton, Jim Black, Carolyn M. TI Evaluation of the Rapid BioStar Optical Immunoassay for Detection of Chlamydia trachomatis in Adolescent Women SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID ACID AMPLIFICATION TESTS; INFECTION; DISEASE; DIAGNOSIS; ASSAY; LEAD AB We evaluated the performance of the BioStar Chlamydia OIA (optical immunoassay) in adolescent females (n = 261) from an inner city population. With a reference standard of two different nucleic acid amplification tests, the sensitivity and specificity of the BioStar Chlamydia OIA were 59.4 and 98.4%, respectively. Due to its relatively low sensitivity, the BioStar Chlamydia OIA should only be used in conjunction with more sensitive laboratory tests unless laboratory tests are unavailable or timely return for treatment is unlikely. C1 [Bandea, Claudiu I.; Dover, Jason; Unger, Elizabeth R.; Black, Carolyn M.] Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Atlanta, GA 30333 USA. [Koumans, Emilia H.; O'Connor, Angelica; Papp, John R.; Braxton, Jim] Ctr Dis Control & Prevent, Natl Ctr HIV STD & TB Prevent, Atlanta, GA 30333 USA. [Sawyer, Mary K.] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA. RP Black, CM (reprint author), Ctr Dis Control & Prevent, Natl Ctr Infect Dis, MS C-17,1600 Clifton Rd, Atlanta, GA 30333 USA. EM cblack@cdc.gov OI Unger, Elizabeth/0000-0002-2925-5635 NR 13 TC 13 Z9 14 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JAN PY 2009 VL 47 IS 1 BP 215 EP 216 DI 10.1128/JCM.01338-08 PG 2 WC Microbiology SC Microbiology GA 390IR UT WOS:000262158000031 PM 19005149 ER PT J AU Lockhart, SR Messer, SA Pfaller, MA Diekema, DJ AF Lockhart, Shawn R. Messer, Shawn A. Pfaller, Michael A. Diekema, Daniel J. TI Identification and Susceptibility Profile of Candida fermentati from a Worldwide Collection of Candida guilliermondii Clinical Isolates SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID BLOOD-STREAM INFECTIONS; ANTIFUNGAL SUSCEPTIBILITY; GLOBAL SURVEILLANCE; SPP.; PARAPSILOSIS; CASPOFUNGIN; ANIDULAFUNGIN; ORTHOPSILOSIS; METAPSILOSIS; FLUCONAZOLE AB Candida fermentati isolates make up a small percentage of the clinical isolates of the Candida guilliermondii complex and have a global distribution pattern. With the exception that the MICs of micafungin were significantly lower, the calculated average MICs for C. fermentati were not significantly different from those for C. guilliermondii. C1 [Lockhart, Shawn R.; Messer, Shawn A.; Pfaller, Michael A.; Diekema, Daniel J.] Univ Iowa, Carver Coll Med, Iowa City, IA 52242 USA. RP Lockhart, SR (reprint author), Ctr Dis Control & Prevent, Mycot Dis Branch, 1600 Clifton Rd,Mail Stop G-11, Atlanta, GA 30333 USA. EM gyi2@cdc.gov OI Diekema, Daniel/0000-0003-1273-0724 NR 20 TC 23 Z9 24 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JAN PY 2009 VL 47 IS 1 BP 242 EP 244 DI 10.1128/JCM.01889-08 PG 3 WC Microbiology SC Microbiology GA 390IR UT WOS:000262158000039 PM 19036938 ER PT J AU Somoskovi, A Dormandy, J Mayrer, AR Carter, M Hooper, N Salfinger, M AF Somoskovi, Akos Dormandy, Jillian Mayrer, Andrew R. Carter, Martin Hooper, Nancy Salfinger, Max TI "Mycobacterium canettii" Isolated from a Human Immunodeficiency Virus-Positive Patient: First Case Recognized in the United States SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID TUBERCULOSIS COMPLEX; RAPID DIFFERENTIATION; GENE POLYMORPHISM; TUBERCLE-BACILLI; HSP65 GENE; BOVIS; IDENTIFICATION; PYRAZINAMIDE; RESISTANCE; MUTATION AB We report the first case of tuberculosis caused by "Mycobacterium canettii" recognized in the United States. The pathogen was isolated from the cerebrospinal fluid of a 30-year-old Sudanese refugee. C1 [Salfinger, Max] Florida Dept Hlth, Bur Labs, Tallahassee, FL 32399 USA. [Somoskovi, Akos] Ctr Dis Control & Prevent, Int Lab Branch, Global AIDS Program, Atlanta, GA USA. [Dormandy, Jillian] New York State Dept Hlth, Wadsworth Ctr, Albany, NY USA. [Mayrer, Andrew R.] Sinai Hosp, Dept Med, Div Infect Dis, Baltimore, MD 21215 USA. [Hooper, Nancy] Maryland Dept Hlth & Mental Hyg, Labs Adm, Baltimore, MD 21201 USA. RP Salfinger, M (reprint author), Florida Dept Hlth, Bur Labs, 4052 Bald Cypress Way,HQ Bin A-15, Tallahassee, FL 32399 USA. EM max_salfinger@doh.state.fl.us NR 25 TC 13 Z9 13 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JAN PY 2009 VL 47 IS 1 BP 255 EP 257 DI 10.1128/JCM.01268-08 PG 3 WC Microbiology SC Microbiology GA 390IR UT WOS:000262158000044 PM 19020064 ER PT J AU Patel, MM Hall, AJ Vinje, J Parashara, UD AF Patel, Manish M. Hall, Aron J. Vinje, Jan Parashara, Urnesh D. TI Noroviruses: A comprehensive review SO JOURNAL OF CLINICAL VIROLOGY LA English DT Review DE Norovirus; NoV; Calicivirus; Review; Diarrhea; Gastroenteritis ID NORWALK-LIKE VIRUSES; INFECTIOUS NONBACTERIAL GASTROENTERITIS; OYSTER-ASSOCIATED GASTROENTERITIS; WINTER VOMITING DISEASE; BLOOD GROUP ANTIGENS; HUMAN CALICIVIRUSES; MOLECULAR EPIDEMIOLOGY; VIRAL GASTROENTERITIS; UNITED-STATES; HOSPITALIZED CHILDREN C1 [Patel, Manish M.; Hall, Aron J.; Parashara, Urnesh D.] Ctr Dis Control & Prevent, Epidemiol Branch, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Vinje, Jan] Ctr Dis Control & Prevent, Gastroenteritis & Resp Virus Lab Branch, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Patel, MM (reprint author), Ctr Dis Control & Prevent, Epidemiol Branch, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, MS-A47,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM Aul3@CDC.GOV OI Vinje, Jan/0000-0002-1530-3675 NR 100 TC 344 Z9 362 U1 12 U2 116 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1386-6532 J9 J CLIN VIROL JI J. Clin. Virol. PD JAN PY 2009 VL 44 IS 1 BP 1 EP 8 DI 10.1016/j.jcv.2008.10.009 PG 8 WC Virology SC Virology GA 398WA UT WOS:000262761000002 PM 19084472 ER PT J AU Xu, J Yang, Y Sun, JE Ding, YZ Su, LY Fang, Z Glass, RI AF Xu, Jin Yang, Yi Sun, Jiae Ding, Yunzhen Su, Liyun Fang, Zhaoyin Glass, Roger I. TI Molecular epidemiology of rotavirus infections among children hospitalized for acute gastroenteritis in Shanghai, China, 2001 through 2005 SO JOURNAL OF CLINICAL VIROLOGY LA English DT Article DE Rotavirus; Gastroenteritis; Genotype; Children ID BRAZILIAN CHILDREN; DIARRHEA; STRAINS; IDENTIFICATION; SURVEILLANCE; INDIA; PCR; G8 AB Background: Rotavirus is the most common Cause of severe diarrhea in children in the world. Knowing the prevalence and genotypes of these infections is important for implementing vaccination programs. Objectives: To determine the prevalence and genotypes of rotavirus infections in Shanghai, China between 2001 and 2005. Study design: Stool specimens were analyzed from children under 5 years old who were hospitalized for acute gastroenteritis. Results: 0175411 specimens, 1436(26.5%) were rotavirus-positive. More than 80% of children with rotavirus infections were younger than 2 years old. Prevalence peaked from October to December each year. The G3, P[8], and P[8]G3 genotypes were the most common during these 5 years. The prevalence of the G I genotype decreased from 29% in 2001 to 2% in 2004. Conclusions: In Shanghai, use of currently available vaccines against rotaviruses would be effective, especially for infants less than 2 years old. Information on the variations of circulating genotypes in this area of China provides useful data for formulating vaccine policy and evaluating vaccine efficacy. (c) 2008 Elsevier B.V. All rights reserved. C1 [Xu, Jin; Yang, Yi; Sun, Jiae; Ding, Yunzhen; Su, Liyun] Fudan Univ, Childrens Hosp, Inst Pediat, Shanghai 200032, Peoples R China. [Fang, Zhaoyin] Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Viral Gastroenteritis Div, Beijing, Peoples R China. [Glass, Roger I.] Ctr Dis Control & Prevent, Gastroenteritis & Resp Virus Lab Branch, Div Viral Dis, Atlanta, GA USA. RP Xu, J (reprint author), Fudan Univ, Childrens Hosp, Inst Pediat, 183 Fenglin Rd, Shanghai 200032, Peoples R China. EM janexu125@hotmail.com FU PATH (Program for Appropriate Technology in Health) [HS251]; Fudan University FX This study was supported by funding from PATH (Program for Appropriate Technology in Health) (grant HS251) and funding from Fudan University. NR 27 TC 12 Z9 15 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1386-6532 J9 J CLIN VIROL JI J. Clin. Virol. PD JAN PY 2009 VL 44 IS 1 BP 58 EP 61 DI 10.1016/j.jcv.2008.09.012 PG 4 WC Virology SC Virology GA 398WA UT WOS:000262761000013 PM 19010730 ER PT J AU Ashley, K Applegate, GT Marcy, AD Drake, PL Pierce, PA Carabin, N Demange, M AF Ashley, Kevin Applegate, Gregory T. Marcy, A. Dale Drake, Pamela L. Pierce, Paul A. Carabin, Nathalie Demange, Martine TI Evaluation of sequential extraction procedures for soluble and insoluble hexavalent chromium compounds in workplace air samples SO JOURNAL OF ENVIRONMENTAL MONITORING LA English DT Article ID WELDING FUMES; ULTRASONIC EXTRACTION; FIELD METHOD; SPECTROMETRY AB Because toxicities may differ for Cr(VI) compounds of varying solubility, some countries and organizations have promulgated different occupational exposure limits (OELs) for soluble and insoluble hexavalent chromium (Cr(VI)) compounds, and analytical methods are needed to determine these species in workplace air samples. To address this need, international standard methods ASTM D6832 and ISO 16740 have been published that describe sequential extraction techniques for soluble and insoluble Cr(VI) in samples collected from occupational settings. However, no published performance data were previously available for these Cr(VI) sequential extraction procedures. In this work, the sequential extraction methods outlined in the relevant international standards were investigated. The procedures tested involved the use of either deionized water or an ammonium sulfate/ammonium hydroxide buffer solution to target soluble Cr(VI) species. This was followed by extraction in a sodium carbonate/sodium hydroxide buffer solution to dissolve insoluble Cr(VI) compounds. Three-step sequential extraction with (1) water, (2) sulfate buffer and (3) carbonate buffer was also investigated. Sequential extractions were carried out on spiked samples of soluble, sparingly soluble and insoluble Cr(VI) compounds, and analyses were then generally carried out by using the diphenylcarbazide method. Similar experiments were performed on paint pigment samples and on airborne particulate filter samples collected from stainless steel welding. Potential interferences from soluble and insoluble Cr(III) compounds, as well as from Fe(II), were investigated. Interferences from Cr(III) species were generally absent, while the presence of Fe(II) resulted in low Cr(VI) recoveries. Two-step sequential extraction of spiked samples with (first) either water or sulfate buffer, and then carbonate buffer, yielded quantitative recoveries of soluble Cr(VI) and insoluble Cr(VI), respectively. Three-step sequential extraction gave excessively high recoveries of soluble Cr(VI), low recoveries of sparingly soluble Cr(VI), and quantitative recoveries of insoluble Cr(VI). Experiments on paint pigment samples using two- step extraction with water and carbonate buffer yielded varying percentages of relative fractions of soluble and insoluble Cr(VI). Sequential extractions of stainless steel welding fume air filter samples demonstrated the predominance of soluble Cr(VI) compounds in such samples. The performance data obtained in this work support the Cr(VI) sequential extraction procedures described in the international standards. C1 [Ashley, Kevin; Applegate, Gregory T.] NIOSH, US Dept HHS, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Marcy, A. Dale; Drake, Pamela L.; Pierce, Paul A.] NIOSH, US Dept HHS, Ctr Dis Control & Prevent, Spokane, WA 99207 USA. [Marcy, A. Dale] N Idaho Coll, Coeur Dalene, ID 83814 USA. [Carabin, Nathalie; Demange, Martine] Inst Natl Rech & Secur, Dept Metrol Polluants, CS 60027, F-54519 Vandoeuvre Les Nancy, France. RP Ashley, K (reprint author), NIOSH, US Dept HHS, Ctr Dis Control & Prevent, 4676 Columbia Pkwy,Mail Stop R-7, Cincinnati, OH 45226 USA. EM KAshley@cdc.gov RI Ashley, Kevin/C-9005-2011; Demange, Marc/A-7441-2015 FU National Occupational Research Agenda (NORA) FX This work was partially funded under the auspices of a National Occupational Research Agenda (NORA) project on hexavalent chromium in stainless steel welding. NR 28 TC 8 Z9 9 U1 0 U2 8 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1464-0325 J9 J ENVIRON MONITOR JI J. Environ. Monit. PY 2009 VL 11 IS 2 BP 318 EP 325 DI 10.1039/b812236a PG 8 WC Chemistry, Analytical; Environmental Sciences SC Chemistry; Environmental Sciences & Ecology GA 406DP UT WOS:000263275500022 PM 19212588 ER PT J AU Page, SJ Volkwein, JC AF Page, Steven J. Volkwein, Jon C. TI A revised conversion factor relating respirable dust concentrations measured by 10 mm Dorr-Oliver nylon cyclones operated at 1.7 and 2.0 L min(-1) SO JOURNAL OF ENVIRONMENTAL MONITORING LA English DT Article ID AEROSOL SAMPLER AB Accurate measurement of workplace respirable dust concentration is an essential step in eliminating lung disease in any occupational setting. In the United States (U. S.) coal mining industry, this measurement process has relied upon a personal sampler that includes a 10 mm Dorr-Oliver (DO) nylon cyclone operated at a flow rate of 2.0 L min(-1) to collect a respirable dust sample. Dust concentrations measured with this sampler are multiplied by 1.38, which was empirically derived, to convert them to measurements approximating the United Kingdom British Medical Research Council (BMRC) definition of respirable dust upon which the health effects of coal mine dust are based. The International Organization for Standardization (ISO) subsequently refined the respirable dust definition and the U. S. National Institute for Occupational Safety and Health (NIOSH) 1995 Criteria for a Recommended Standard presented a conversion multiplier of 0.857 to apply to the 2.0 L min(-1) DO (in addition to the 1.38 multiplier) to obtain equivalent ISO concentrations, as approximated by the 1.7 L min(-1) DO. However, the conversion multiplier 0.857 was derived indirectly from a limited size distribution data set rather than a direct comparison of the DO samplers. The present analysis focuses on providing a more accurate conversion multiplier derived from direct comparisons of the 2.0 L min(-1) (with 1.38 BMRC equivalency multiplier) and 1.7 L min(-1) DO cyclones. A weighted linear regression analysis of this database suggests that a more accurate estimate of the conversion multiplier is 0.815. C1 [Page, Steven J.; Volkwein, Jon C.] NIOSH, US Dept HHS, Publ Hlth Serv, Ctr Dis Control & Prevent,Pittsburgh Res Lab, Pittsburgh, PA 15236 USA. RP Page, SJ (reprint author), NIOSH, US Dept HHS, Publ Hlth Serv, Ctr Dis Control & Prevent,Pittsburgh Res Lab, 626 Cochrans Mill Rd, Pittsburgh, PA 15236 USA. NR 18 TC 3 Z9 3 U1 1 U2 2 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1464-0325 J9 J ENVIRON MONITOR JI J. Environ. Monit. PY 2009 VL 11 IS 3 BP 684 EP 689 DI 10.1039/b817922k PG 6 WC Chemistry, Analytical; Environmental Sciences SC Chemistry; Environmental Sciences & Ecology GA 417SO UT WOS:000264098400024 PM 19280048 ER PT J AU Weerasekera, G Smith, KD Quiros-Alcala, L Fernandez, C Bradman, A Eskenazi, B Needham, LL Barr, DB AF Weerasekera, Gayanga Smith, Kimberly D. Quiros-Alcala, Lesliam Fernandez, Carolina Bradman, Asa Eskenazi, Brenda Needham, Larry L. Barr, Dana B. TI A mass spectrometry-based method to measure dialkylphosphate degradation products of organophosphorous insecticides in dust and orange juice SO JOURNAL OF ENVIRONMENTAL MONITORING LA English DT Article ID DIALKYL PHOSPHATE METABOLITES; PESTICIDE EXPOSURE; PRESCHOOL-CHILDREN; AGRICULTURAL COMMUNITY; WASHINGTON-STATE; RISK-ASSESSMENT; URINE; 3,5,6-TRICHLORO-2-PYRIDINOL; CHLORPYRIFOS; POPULATIONS AB Dialkylphosphates (DAPs) are urinary metabolites and breakdown products of organophosphorous (OP) pesticides. Urinary DAPs are widely used to assess exposure to OP pesticides in epidemiologic studies. Recent evidence suggests that preformed DAPs are present in food and that they may also be present in other parts of the environment. Thus, DAP concentrations observed in urine may reflect a person's exposure to both parent OP pesticides and preformed DAPs in food and other environmental media. The presence of preformed DAPs in multiple media may indicate that previous studies have overestimated exposure to OP pesticides and that the use of urinary DAPs as biomarkers of exposure for OP pesticides may not accurately characterize exposure in non-acute settings. To establish the presence of DAPs in environmental and food media, we developed analytical methods to measure six DAPs in dust and orange juice. The limits of detection (LOD) for the dimethyl phosphates (dimethylphosphate (DMP), dimethylthiophosphate, and dimethyldithiophosphate) ranged from 2.8-9.9 ng g(-1) and 0.2-0.4 ng mL(-1) in dust and juice, respectively. The LODs for the diethyl phosphates (diethylphosphate (DEP), diethylthiophosphate, diethyldithiophosphate) ranged from 5.2-10.4 ng g(-1) and 0.5-3.0 ng mL(-1) in dust and juice, respectively. The extraction efficiencies for the analytes ranged from 23% to 91% and from 41% to 85% in dust and orange juice, respectively. DMP was detected in about half of the dust samples whereas DEP was detected in 80% of the dust samples tested. Other DAPs were less frequently detected in dust. Less than 3% of intact pesticide present in the matrices was converted to their respective DAPs during the pre-analytic and analytic process. Evaluation of the conversion of intact pesticides in the samples to DAPs will help us to better understand the contribution of preformed DAPs to urinary DAP concentrations. C1 [Weerasekera, Gayanga; Smith, Kimberly D.; Fernandez, Carolina; Needham, Larry L.; Barr, Dana B.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA. [Quiros-Alcala, Lesliam; Bradman, Asa; Eskenazi, Brenda] Univ Calif Berkeley, Sch Publ Hlth, Ctr Childrens Environm Hlth Res, Berkeley, CA 94720 USA. RP Barr, DB (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, 4770 Buford Highway NE,Mailstop F-17, Atlanta, GA 30333 USA. EM dbarr@cdc.gov RI Needham, Larry/E-4930-2011; Barr, Dana/E-6369-2011; Barr, Dana/E-2276-2013; Quiros-Alcala, Lesliam /Q-4928-2016 OI Quiros-Alcala, Lesliam /0000-0002-6600-7227 NR 31 TC 12 Z9 12 U1 1 U2 12 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1464-0325 EI 1464-0333 J9 J ENVIRON MONITOR JI J. Environ. Monit. PY 2009 VL 11 IS 7 BP 1345 EP 1351 DI 10.1039/b821841b PG 7 WC Chemistry, Analytical; Environmental Sciences SC Chemistry; Environmental Sciences & Ecology GA 468HR UT WOS:000267808500004 PM 20449223 ER PT J AU Ozkaynak, H Glenn, B Qualters, JR Strosnider, H McGeehin, MA Zenick, H AF Oezkaynak, Haluk Glenn, Barbara Qualters, Judith R. Strosnider, Heather McGeehin, Michael A. Zenick, Harold TI Summary and findings of the EPA and CDC symposium on air pollution exposure and health SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY LA English DT Article DE air pollution; exposure; health information; surveillance; tracking; accountability ID DAILY MORTALITY; PARTICULATE; ASSOCIATIONS; TRACKING; DISEASE; COUNTY; OZONE AB The U. S. Environmental Protection Agency (EPA) and the U. S. Centers for Disease Control (CDC) co-organized a symposium on "Air Pollution Exposure and Health" at Research Triangle Park, North Carolina on September 19-20, 2006. The symposium brought together health and environmental scientists to discuss the state of the science and the cross-jurisdictional and methodological challenges in conducting air pollution epidemiology, environmental public health tracking and accountability research. The symposium was held over 2 days and consisted of technical presentations and breakout group discussions on each of the three principal themes of this meeting: (1) monitoring and exposure modeling information, (2) health effects data and (3) linkage of air quality and health data for research, tracking and accountability. This paper summarizes the symposium presentations and the conclusions and recommendations developed during the meeting. The accompanying two papers, which appear in this issue of the Journal, provide more in-depth discussion of issues pertinent to obtaining and analyzing air pollution exposure and health information. The symposium succeeded in identifying areas where there are critical gaps of knowledge in existing air pollution exposure and health information and in discovering institutional or programmatic barriers, which impede accessing and linking disparate data sets. Several suggestions and recommendations emerged from this meeting, directed toward (1) improving the utility of air monitoring data for exposure quanti. cation, (2) improving access to and the quality of health data, (3) studying emerging air quality and health issues, (4) exploring improved or novel methods for linking data and (5) developing partnerships, building capacity and facilitating interdisciplinary communication. The meeting was successful in promoting an interdisciplinary dialogue around these issues and in formulating strategies to support these recommended activities. Finally, this symposium subsequently led to strengthening and initiating new partnerships or interactions between the EPA, CDC, States, academia and the research community at large. C1 [Glenn, Barbara] US EPA, Natl Ctr Environm Res, Washington, DC 20460 USA. [Qualters, Judith R.; Strosnider, Heather; McGeehin, Michael A.] US Ctr Dis Control & Prevent, Div Environm Hazards & Hlth Effects, Atlanta, GA USA. [Oezkaynak, Haluk] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Zenick, Harold] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. RP Ozkaynak, H (reprint author), US EPA, Natl Exposure Res Lab E205 01, Res Triangle Pk, NC 27711 USA. EM ozkaynak.haluk@epa.gov FU The United States Environmental Protection Agency through its Office of Research and Development; United States Centers for Disease Control through its Division of Environmental Hazards and Health Effects [EP-C-05-015]; SCG Inc. [200-2004-03409/0491] FX The United States Environmental Protection Agency through its Office of Research and Development and the United States Centers for Disease Control through its Division of Environmental Hazards and Health Effects have partially funded and collaborated in the research described here under EPA contract no. EP-C-05-015 to SCG Inc. and under CDC contract no. 200-2004-03409/0491 to Northrop Grumman to provide the services of Nancy Tosta (Ross Associates). This manuscript has been subjected to both EPA and CDC Agency reviews and approved for publication. The findings and conclusions of this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 21 TC 10 Z9 10 U1 1 U2 11 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1559-0631 J9 J EXPO SCI ENV EPID JI J. Expo. Sci. Environ. Epidemiol. PD JAN PY 2009 VL 19 IS 1 BP 19 EP 29 DI 10.1038/jes.2008.34 PG 11 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 384YF UT WOS:000261779400002 PM 18560447 ER PT J AU Caldwell, KL Jones, RL Verdon, CP Jarrett, JM Caudill, SP Osterloh, JD AF Caldwell, Kathleen L. Jones, Robert L. Verdon, Carl P. Jarrett, Jeffery M. Caudill, Samuel P. Osterloh, John D. TI Levels of urinary total and speciated arsenic in the US population: National Health and Nutrition Examination Survey 2003-2004 SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY LA English DT Article DE speciated arsenic; human; urine; biomonitoring; NHANES ID DRINKING-WATER; METHYLATED METABOLITES; EXPOSURE; EXCRETION; ADULTS; BANGLADESH; CHILDREN AB Objective: To provide levels of total and speciated urinary arsenic in a representative sample of the US population. Methods: For the first time, total arsenic and seven inorganic and organic arsenic species were measured in the urine of participants (n = 2557) for the 2003-2004 National Health and Nutrition Examination Survey (NHANES). Data were compiled as geometric means and selected percentiles of urinary arsenic concentrations (mu g/l) and creatinine-corrected urinary arsenic (mu g/g creatinine) for total arsenic, dimethylarsinic acid, arsenobetaine, and a sum of the inorganic related species. Results: Arsenic acid, arsenous acid, arsenocholine, and trimethylarsine oxide were detected in 7.6%, 4.6%, 1.8%, and 0.3% of the participants, respectively (the limits of detection of 0.6-1.2 mu g/l). Monomethylarsonic acid was detected in 35% of the overall population. For all participants aged >= 6 years, dimethylarsinic acid (geometric mean of 3.71 mu g/l) and arsenobetaine (geometric mean of 1.55 mu g/l) had the greatest contribution to the total urinary arsenic levels. A relatively greater percentage contribution from arsenobetaine is seen at higher total urinary arsenic levels and from dimethylarsinic acid at lower total urinary arsenic levels. For all participants aged >= 6 years, the 95th percentiles for total urinary arsenic and the sum of inorganic-related arsenic (arsenic acid, arsenous acid, dimethylarsinic acid, and monomethylarsonic acid) were 65.4 and 18.9 mu g/l, respectively. For total arsenic and dimethylarsinic acid, covariate-adjusted geometric means demonstrated several slight differences due to age, gender, and race/ethnicity. Conclusions: The data reflect relative background contributions of inorganic and seafood-related arsenic exposures in the US population. Arsenobetaine and dimethylarsinic acid are the major arsenic species present with arsenobetaine, accounting for a greater proportion of total arsenic as total arsenic levels increase. C1 [Caldwell, Kathleen L.; Jones, Robert L.; Verdon, Carl P.; Jarrett, Jeffery M.; Caudill, Samuel P.; Osterloh, John D.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30341 USA. RP Caldwell, KL (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, 4770 Buford Hwy NE,Mailstop F-18, Atlanta, GA 30341 USA. EM kcaldwell@cdc.gov RI Caldwell, Kathleen/B-1595-2009; OI Jarrett, Jeffery/0000-0001-5755-3552 NR 35 TC 88 Z9 88 U1 2 U2 26 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1559-0631 J9 J EXPO SCI ENV EPID JI J. Expo. Sci. Environ. Epidemiol. PD JAN PY 2009 VL 19 IS 1 BP 59 EP 68 DI 10.1038/jes.2008.32 PG 10 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 384YF UT WOS:000261779400005 PM 18523458 ER PT J AU Lu, CS Barr, DB Pearson, MA Walker, LA Bravo, R AF Lu, Chensheng Barr, Dana B. Pearson, Melanie A. Walker, Lance A. Bravo, Roberto TI The attribution of urban and suburban children's exposure to synthetic pyrethroid insecticides: a longitudinal assessment SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY LA English DT Article DE children's pesticide exposure; longitudinal exposure; PBA; pyrethroid insecticides; pyrethroid metabolites; urinary biomarker ID ORGANOPHOSPHORUS PESTICIDE EXPOSURE; PRESCHOOL-CHILDREN; PERMETHRIN; DIETARY; RATS; TOXICOKINETICS; DELTAMETHRIN; METABOLITES; POPULATION; URINE AB Despite the widespread use of synthetic pyrethroid insecticides that led to common exposure in the population, very few studies have been conducted to quantitatively assess human, particularly, children's, long-term exposures to pyrethroid insecticides. The objective of the Children Pesticide Exposure Study-Washington (CPES-WA) was to establish the longitudinal exposure profiles for pyrethroid insecticides in a cohort of children living in an urban and suburban community using urinary pyrethroid metabolites as exposure biomarkers. The results from this analysis will allow us to examine potential risk factors in relation to the elevated pyrethroid insecticide exposure in children. A total of 23 children, aged 3-11 years, who only consumed conventional diets were enrolled in this 1-year study. We provided organic food items to children for 5 consecutive days in the summer and fall sampling seasons. We measured urinary metabolites for the synthetic pyrethroid insecticides in urine samples that were collected twice daily during each of the four sampling seasons. 3-phenoxybenzoic acid was frequently detected in the urine samples with mean and median daily volume-weighted average levels of 1.5 and 1.2 mg/l, followed by trans-2,2-(dichloro)-2-dimethylvinylcyclopropane carboxylic acid (1.4 and 1.0 mg/l) and cis-2,2-(dichloro)-2-dimethylvinylcyclopropane carboxylic acid (0.5 mg/l, and non-detected). When we took into account season, age, sex, diet, and self-reported residential use of pyrethroid insecticides in a linear mixed-effects model, the results suggested that the combination of the use of pyrethroid insecticides in the household, dietary intake, and seasonal differences play a significant role in predicting children's exposure to synthetic pyrethroid insecticides. We found CPES-WA children were continuously exposed to pyrethroid insecticides through their diets all year long, and this chronic exposure pattern was periodically modified by episodes of relatively high exposures from residential uses. Future research should be devoted to enhancing our understanding of the complexity of pyrethroid insecticide exposure patterns. C1 [Lu, Chensheng; Pearson, Melanie A.] Emory Clin, Rollins Sch Publ Hlth, Dept Environm & Occupat Hlth, Atlanta, GA 30322 USA. [Barr, Dana B.; Bravo, Roberto] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. [Walker, Lance A.] Emory Clin, Rollins Sch Publ Hlth, Dept Biostat, Atlanta, GA 30322 USA. RP Lu, CS (reprint author), Emory Clin, Rollins Sch Publ Hlth, Dept Environm & Occupat Hlth, 1518 Clifton Rd NE, Atlanta, GA 30322 USA. EM clu2@sph.emory.edu RI Barr, Dana/E-6369-2011; Barr, Dana/E-2276-2013 FU US Environmental Protection Agency [RD-829364]; National Center for Environmental Health in the Centers for Disease Control and Prevention, Atlanta, GA FX This study was supported by the US Environmental Protection Agency, Science to Achieve Results program (RD-829364) and the National Center for Environmental Health in the Centers for Disease Control and Prevention, Atlanta, GA. Its contents are solely the responsibility of the authors and do not necessarily represent the official view of US EPA or CDC. We express our sincere appreciation to the children who participated and to their parents who greatly assisted in this study. We also thank Rene Irish, Kathryn Toepel, Patrick Sande, and Richard Fenske at the University of Washington, Seattle, WA, for their assistance in conducting this study, and Paula Restrepo, Jessica Norrgran, Robert Walker, and Charles Chambers at the NCEH/CDC for their help with sample analysis and data management. NR 29 TC 37 Z9 38 U1 3 U2 9 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1559-0631 EI 1559-064X J9 J EXPO SCI ENV EPID JI J. Expo. Sci. Environ. Epidemiol. PD JAN PY 2009 VL 19 IS 1 BP 69 EP 78 DI 10.1038/jes.2008.49 PG 10 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 384YF UT WOS:000261779400006 PM 18766203 ER PT J AU Bradman, A Salvatore, AL Boeniger, M Castorina, R Snyder, J Barr, DB Jewell, NP Kavanagh-Baird, G Striley, C Eskenazi, B AF Bradman, Asa Salvatore, Alicia L. Boeniger, Mark Castorina, Rosemary Snyder, John Barr, Dana B. Jewell, Nicholas P. Kavanagh-Baird, Geri Striley, Cynthia Eskenazi, Brenda TI Community-based intervention to reduce pesticide exposure to farmworkers and potential take-home exposure to their families SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY LA English DT Article DE pesticides; malathion; farmworkers; agriculture; transfer coefficients; biomarkers ID DIALKYL PHOSPHATE METABOLITES; TANDEM MASS-SPECTROMETRY; ORGANOPHOSPHORUS PESTICIDES; PERSONAL PROTECTION; HUMAN URINE; CALIFORNIA; HARVESTERS; CHILDREN; WORKERS; QUANTIFICATION AB The US EPA Worker Protection Standard requires pesticide safety training for farmworkers. Combined with re-entry intervals, these regulations are designed to reduce pesticide exposure. Little research has been conducted on whether additional steps may reduce farmworker exposure and the potential for take-home exposure to their families. We conducted an intervention with 44 strawberry harvesters (15 control and 29 intervention group members) to determine whether education, encouragement of handwashing, and the use of gloves and removable coveralls reduced exposure. Post-intervention, we collected foliage and urine samples, as well as hand rinse, lower-leg skin patch, and clothing patch samples. Post-intervention loading of malathion on hands was lower among workers who wore gloves compared to those who did not (median = 8.2 vs. 777.2 mu g per pair, respectively (P < 0.001)); similarly, median MDA levels in urine were lower among workers who wore gloves (45.3 vs. 131.2 mu g/g creatinine, P < 0.05). Malathion was detected on clothing (median 0.13 mu g/cm(2)), but not on skin. Workers who ate strawberries had higher malathion dicarboxylic acid levels in urine (median = 114.5 vs. 39.4 mu g/g creatinine, P < 0.01). These findings suggest that wearing gloves reduces pesticide exposure to workers contacting strawberry foliage containing dislodgeable residues. Additionally, wearing gloves and removing work clothes before returning home could reduce transport of pesticides to worker homes. Behavioral interventions are needed to reduce consumption of strawberries in the field. C1 [Bradman, Asa; Salvatore, Alicia L.; Castorina, Rosemary; Jewell, Nicholas P.; Eskenazi, Brenda] Univ Calif Berkeley, Sch Publ Hlth, Ctr Childrens Environm Hlth Res, Berkeley, CA 94720 USA. [Boeniger, Mark; Striley, Cynthia] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH 45226 USA. [Snyder, John] Univ Kentucky, Dept Hort, Lexington, KY 40546 USA. [Barr, Dana B.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. [Kavanagh-Baird, Geri] Clin Salud Valle Salinas, CHAMACOS, Salinas, CA USA. RP Bradman, A (reprint author), Univ Calif Berkeley, Sch Publ Hlth, Ctr Childrens Environm Hlth Res, 2150 Shattuck Ave,Suite 600, Berkeley, CA 94720 USA. EM abradman@socrates.berkeley.edu RI Barr, Dana/E-6369-2011; Barr, Dana/E-2276-2013 FU NIEHS CBPR [RO1ES11352]; US EPA [RD 83171001]; NIEHS [PO1 ES009605] FX This research was funded by NIEHS CBPR Grant RO1ES11352. Additional support was provided by US EPA Grant RD 83171001 and NIEHS Grant PO1 ES009605. Analysis for hand rinse, clothing patch, and DFR samples was supported by NIOSH. Additional support for environmental sample collection analysis and M Boeniger's time was provided by NIOSH. The contents of this paper are the responsibility of the authors and do not necessarily represent the official views of the funding agencies. The authors declare they have no competing financial interests. We thank the field staff and the farm-workers and farmers who participated in this study for their valuable time and commitment. We also thank Natividad Medical Center for hosting our field office in Salinas, CA. NR 43 TC 22 Z9 23 U1 2 U2 19 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1559-0631 J9 J EXPO SCI ENV EPID JI J. Expo. Sci. Environ. Epidemiol. PD JAN PY 2009 VL 19 IS 1 BP 79 EP 89 DI 10.1038/jes.2008.18 PG 11 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 384YF UT WOS:000261779400007 PM 18368011 ER PT J AU French, RS Mercer, CH Johnson, AM Fenton, KA Erens, B Wellings, K AF French, Rebecca S. Mercer, Catherine H. Johnson, Anne M. Fenton, Kevin A. Erens, Bob Wellings, Kaye TI Use of contraceptive services in Britain: findings from the second National Survey of Sexual Attitudes and Lifestyles (Natsal-2) SO JOURNAL OF FAMILY PLANNING AND REPRODUCTIVE HEALTH CARE LA English DT Article DE contraceptive service use; Natsal-2; sexual behaviour; sexual health ID TEENAGE PREGNANCY STRATEGY; HEALTH-SERVICES; ENGLAND AB Objective To describe contraceptive service use and identify demographic and sexual behavioural characteristics associated with use (and non-use) of different services. Methods Probability survey sample of men and women aged 16-44 years, resident in Britain. Participants comprised 3369 men and 4375 women reporting vaginal intercourse in the last year (excluding those reporting exclusive use of sterilisation or medical investigations for infertility). Main outcome measures were use of contraceptive services, grouped as: general practice, community contraceptive clinics, retail services and non-use of services. Results General practice was the most commonly reported source of contraceptive supplies for women (59.2%), while retail services were most frequently reported by men (42.7%). 16.3% of women and 7.3% of men reported using more than one type of service. 20.7% of women and 45.1% of men had used no service in the last year, and amongst 16-17-year-olds the proportions reporting non-use of services was 13.8% and 31.2%, respectively. Use of community contraceptive clinics was associated with being younger, childless, single and reporting more heterosexual partners in the last year. Conclusions There was relatively little 'shopping around' between different services, suggesting that choice of contraceptive providers ensures a range of needs is met for most people. While general practice is the most commonly used source of supplies, community contraceptive clinics are seeing those potentially at higher sexual health risk, particularly the young and those with multiple partners. Ways of improving young people's access to services for contraceptive supplies need to be addressed. C1 [French, Rebecca S.] UCL, Ctr Sexual Hlth & HIV Res, Margaret Pyke Ctr, Res Dept Infect & Populat Hlth, London W1T 4PL, England. [Fenton, Kevin A.] Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV STD & TB Prevent, Atlanta, GA USA. [Erens, Bob] Natl Ctr Social Res, London, England. [Wellings, Kaye] London Sch Hyg & Trop Med, Dept Publ Hlth & Policy, Ctr Sexual & Reprod Hlth Res, London WC1, England. RP French, RS (reprint author), UCL, Ctr Sexual Hlth & HIV Res, Margaret Pyke Ctr, Res Dept Infect & Populat Hlth, 73 Charlotte St, London W1T 4PL, England. EM rfrench@gum.ucl.ac.uk OI Erens, Robert/0000-0002-3054-504X; Erens, Bob/0000-0002-4430-954X FU Department of Health; Medical Research Council [, G0701757] NR 20 TC 9 Z9 9 U1 1 U2 2 PU PROFESSIONAL, MANAGERIAL & HEALTHCARE PUBLICATIONS LTD PI CHICHESTER PA PO BOX 100, CHICHESTER PO18 8HD, W SUSSEX, ENGLAND SN 1471-1893 J9 J FAM PLAN REPROD H JI J. Fam. Plan. Reprod. Health Care PD JAN PY 2009 VL 35 IS 1 BP 9 EP 14 PG 6 WC Family Studies; Obstetrics & Gynecology; Social Sciences, Biomedical SC Family Studies; Obstetrics & Gynecology; Biomedical Social Sciences GA 394OW UT WOS:000262457100003 PM 19126310 ER PT J AU Lindsey, LLM Silk, KJ Von Friederichs-Fitzwater, MM Hamner, HC Prue, CE Boster, FJ AF Lindsey, Lisa L. Massi Silk, Kami J. Von Friederichs-Fitzwater, Marlene M. Hamner, Heather C. Prue, Christine E. Boster, Franklin J. TI Developing Effective Campaign Messages to Prevent Neural Tube Defects: A Qualitative Assessment of Women's Reactions to Advertising Concepts SO JOURNAL OF HEALTH COMMUNICATION LA English DT Article ID UNITED-STATES; CHILDBEARING AGE; UNINTENDED PREGNANCY; PLANNED BEHAVIOR; BIRTH-DEFECTS; NUTRITION; STUDENTS; RATES AB The incidence of neural tube defects (NTDs), serious birth defects of the brain and spine that affect approximately 3,000 pregnancies in the United States each year, can be reduced by 50-70% with daily periconceptional consumption of the B vitamin folic acid. Two studies were designed to assess college women's reactions to and perceptions of potential campaign advertising concepts derived from preproduction formative research to increase folic acid consumption through the use of a daily multivitamin. Study one assessed draft advertising concepts in eight focus groups (N=71) composed of college-enrolled women in four cities geographically dispersed across the United States. Based on study one results, the concepts were revised and reassessed in study two with a different sample (eight focus groups; N=73) of college women in the same four cities. Results indicated that participants generally responded favorably to concepts in each of the two studies, and provided insight into individual concepts to increase their overall appeal and effectiveness. The specific findings and implications of these results are discussed. C1 [Lindsey, Lisa L. Massi] Michigan State Univ, Coll Commun Arts & Sci, Dept Commun, E Lansing, MI 48824 USA. [Von Friederichs-Fitzwater, Marlene M.] Calif State Univ Sacramento, Davis Sch Med, UC Davis Canc Ctr, Sacramento, CA 95819 USA. [Hamner, Heather C.; Prue, Christine E.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Prevent Res Branch, Atlanta, GA USA. [Boster, Franklin J.] Cometrika, Mason, MI USA. RP Lindsey, LLM (reprint author), Michigan State Univ, Coll Commun Arts & Sci, Dept Commun, E Lansing, MI 48824 USA. EM lindsey@msu.edu NR 36 TC 4 Z9 4 U1 0 U2 8 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 520 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1081-0730 EI 1087-0415 J9 J HEALTH COMMUN JI J. Health Commun. PY 2009 VL 14 IS 2 BP 131 EP 159 AR PII 909487533 DI 10.1080/10810730802659137 PG 29 WC Communication; Information Science & Library Science SC Communication; Information Science & Library Science GA 418GY UT WOS:000264137900004 ER PT J AU Eheman, CR Berkowitz, Z Lee, J Mohile, S Purnell, J Rodriguez, EM Roscoe, J Johnson, D Kirshner, J Morrow, G AF Eheman, Christie R. Berkowitz, Zahava Lee, Judith Mohile, Supriya Purnell, Jason Rodriguez, Elisa Marie Roscoe, Joseph Johnson, David Kirshner, Jeffrey Morrow, Gary TI Information-Seeking Styles Among Cancer Patients Before and After Treatment by Demographics and Use of Information Sources SO JOURNAL OF HEALTH COMMUNICATION LA English DT Article ID STAGE BREAST-CANCER; RADIATION-THERAPY; DECISION-MAKING; HEALTH; NEEDS; PREFERENCES; CARE; INVOLVEMENT; BEHAVIOR; SURGERY AB The type and quantity of information needed varies between patients who actively seek information and those who tend to avoid information.We analyzed data from a longitudinal study of adult cancer patients from outpatient clinics for whom information needs and behaviors were assessed by survey before and after treatment. We evaluated the relationships between information-seeking style (active, moderately active, and passive styles) and demographics, cancer type, and health status for the pretreatment and posttreatment periods and overall. The generalized estimating equations (GEE) approach was used to model the log odds of more active to more passive information-seeking preferences taking into consideration both the pretreatment and posttreatment periods. Analyses included 731 case participants, including female breast cancer patients (51%), male genitourinary cancer patients (18%), and lung cancer patients of both sexes (10%). At pretreatment, 17% reported an active information-seeking style, 69% were moderately active, and 14% were passive. During this period, 19% of those with at least some college education reported being very active compared with 14% of those with less education. With adjustment for all other covariates, male genitourinary and lung cancer patients had a higher odds of having a more active information-seeking style in the pretreatment than in the posttreatment period, with an odds of 4.5 (95% confidence interval [CI]: 2.4-8.4) and 5.4 (95% CI: 2.7-10.6), respectively. Controlling for all covariates, breast cancer patients had 1.5 (95% CI: 1.0-2.1) times higher odds of being more active in seeking information than other patients. Public health researchers and clinicians must work together to develop the most effective strategy for meeting the informational needs of these patients before and after treatment. C1 [Eheman, Christie R.; Berkowitz, Zahava; Lee, Judith] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Mohile, Supriya; Purnell, Jason; Roscoe, Joseph; Morrow, Gary] Univ Rochester, Ctr Canc, Rochester, NY USA. [Rodriguez, Elisa Marie] SUNY Buffalo, Buffalo, NY 14260 USA. [Johnson, David] Wichita Community Clin Oncol Program, Wichita, KS USA. [Kirshner, Jeffrey] Hematol Oncol Associates Cent New York, Syracuse, NY USA. RP Eheman, CR (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway NE, Atlanta, GA 30341 USA. EM cre1@cdc.gov FU NCI NIH HHS [U10 CA037420, R25 CA102618, U10 CA037420-24] NR 41 TC 42 Z9 42 U1 0 U2 13 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1081-0730 J9 J HEALTH COMMUN JI J. Health Commun. PY 2009 VL 14 IS 5 BP 487 EP 502 AR PII 913642820 DI 10.1080/10810730903032945 PG 16 WC Communication; Information Science & Library Science SC Communication; Information Science & Library Science GA 480GC UT WOS:000268719300008 PM 19657928 ER PT J AU Chen, Z Roy, K AF Chen, Zhuo Roy, Kakoli TI Calculating concentration index with repetitive values of indicators of economic welfare SO JOURNAL OF HEALTH ECONOMICS LA English DT Article DE Categorical variable; Concentration index; Health inequalities; Repetitive values ID INCOME-RELATED INEQUALITY; SOCIOECONOMIC INEQUALITY; HEALTH; DENMARK; MATTER; CARE; US AB Repetitive values of the ranking indicators of economic welfare are often introduced due to incidental tier or censoring in the welfare variable, or the categorical nature of welfare variables used in numerous national surveys. In Calculating concentration index (CI), assigning different fractional ranks to observations that have same values of the welfare measure leads to unstable and inconsistent CI estimates when the welfare variable is categorical or censored. In this paper, we establish an interval within which the Cl estimates lie, and propose a solution, which is an extension of (Kakwani, N.C., Wagstaff, A., van Doorslaer, E., 1997. Socioeconomic inequalities in health: measurement, computation, and statistical inference. journal of Econometrics 77, 87-103), for consistent and replicable estimates of CI when there are a substantial number of ties of the welfare indicator. Published by Elsevier B.V. C1 [Chen, Zhuo; Roy, Kakoli] Ctr Dis Control & Prevent, Off Workforce & Career Dev, Atlanta, GA 30333 USA. RP Chen, Z (reprint author), Ctr Dis Control & Prevent, Off Workforce & Career Dev, 1600 Clifton Rd NE,MS-F94, Atlanta, GA 30333 USA. EM chenzhuo@gmail.com OI Chen, Zhuo/0000-0002-5351-3489 NR 32 TC 25 Z9 25 U1 3 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-6296 J9 J HEALTH ECON JI J. Health Econ. PD JAN PY 2009 VL 28 IS 1 BP 169 EP 175 DI 10.1016/j.jhealeco.2008.09.004 PG 7 WC Economics; Health Care Sciences & Services; Health Policy & Services SC Business & Economics; Health Care Sciences & Services GA 404ZE UT WOS:000263190800011 PM 18996608 ER PT J AU Ulanova, TI Obriadina, AP Talekar, G Burkov, AN Fields, HA Khudyakov, YE AF Ulanova, T. I. Obriadina, A. P. Talekar, G. Burkov, A. N. Fields, H. A. Khudyakov, Y. E. TI A New Artificial Antigen of the Hepatitis E Virus SO JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY LA English DT Article DE Artificial antigen; Enzyme immunoassay; Hepatitis E ID LINKED-IMMUNOSORBENT-ASSAY; GLUTATHIONE-S-TRANSFERASE; ESCHERICHIA-COLI; CAPSID PROTEIN; MOSAIC PROTEIN; C VIRUS; NON-A; NON-B; EPITOPES; IMMUNODOMINANT AB An artificial antigen composed of 12 small antigenic regions derived from the ORF2 and ORF3 HEV proteins was designed. The gene encoding for this artificial antigen was assembled from synthetic oligonucleotides by a new method called Restriction Enzyme-Assisted Ligation (REAL). The diagnostic relevance of this second generation HEV mosaic protein (HEV MA-II) was demonstrated by testing this antigen against a panel of 142 well defined anti-HEV positive and anti-HEV negative serum samples. The data obtained in this study support the substantial diagnostic potential of this HEV mosaic antigen. C1 [Talekar, G.; Fields, H. A.; Khudyakov, Y. E.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Ulanova, T. I.; Obriadina, A. P.; Burkov, A. N.] RPC Diagnost Syst, Nizhnii Novgorod, Russia. RP Khudyakov, YE (reprint author), CDC, Div Viral Hepatitis, Atlanta, GA 30333 USA. EM ykhudyakov@cdc.gov NR 50 TC 5 Z9 5 U1 0 U2 1 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1532-1819 J9 J IMMUNOASS IMMUNOCH JI J. Immunoass. Immunoch. PY 2009 VL 30 IS 1 BP 18 EP 39 AR PII 907309269 DI 10.1080/15321810802570269 PG 22 WC Biochemical Research Methods; Immunology; Medical Laboratory Technology SC Biochemistry & Molecular Biology; Immunology; Medical Laboratory Technology GA 389ZH UT WOS:000262133600002 PM 19117200 ER PT J AU Anderson, SE Brown, KK Butterworth, LF Fedorowicz, A Jackson, LG Frasch, HF Beezhold, D Munson, AE Meade, BJ AF Anderson, Stacey E. Brown, Kenneth K. Butterworth, Leon F. Fedorowicz, Adam Jackson, Laurel G. Frasch, H. Fred Beezhold, Don Munson, Albert E. Meade, B. J. TI Evaluation of irritancy and sensitization potential of metalworking fluid mixtures and components SO JOURNAL OF IMMUNOTOXICOLOGY LA English DT Article DE metalworking fluids; LLNA; contact dermatitis; irritancy ID LOCAL LYMPH-NODE; SOLUBLE OIL DERMATITIS; METAL-WORKING FLUIDS; OCCUPATIONAL-EXPOSURE; CONTACT-DERMATITIS; ASSAY; DERMATOSES; RESPONSES; WORKERS; CANCER AB There are approximately 1.2 million workers exposed to metalworking fluids (MWF), which are used to reduce the heat and friction associated with industrial machining and grinding operations. Irritancy and sensitization potential of 9 National Toxicology Program (NTP) nominated MWFs (TRIM 229, TRIM VX, TRIM SC210, CIMTECH 310, CIMPERIAL 1070, CIMSTAR 3800, SYNTILO 1023, SUPEREDGE 6768, and CLEAREDGE 6584) were examined in a combined local lymph node assay ( LLNA). BALB/c mice were dermally exposed to each MWF at concentrations up to 50%. Significant irritation was observed after dermal exposure to all MWFs except CIMTECH 310 and SYNTILO 1023. Of the 9 MWFs, 6 induced greater than a 3-fold increase in lymphocyte proliferation and 7 tested positive in the irritancy assay. TRIM VX yielded the lowest EC3 value (6.9%) with respect to lymphocyte proliferation. Chemical components of TRIM VX identified using HPLC were screened for sensitization potential using structural activity relationship (SAR) modeling and the LLNA. TOPKAT predicted triethanolamine (TEA) as a sensitizer while Derek for Windows predicted only 4-chloro-3-methylphenol (CMP) to be positive for sensitization. When tested in the LLNA only CMP (EC3 = 11.6%) and oleic acid (OA) (EC3 = 29.7%) were identified as sensitizers. Exposure to all tested TRIM VX components resulted in statistically significant irritation. An additive proliferative response was observed when mixtures of the two identified sensitizing TRIM VX components, OA and CMP, were tested in the LLNA. This is one explanation of why the EC3 value of TRIM VX, with respect to lymphocyte proliferation, is lower than those assigned to its sensitizing components. C1 [Anderson, Stacey E.; Butterworth, Leon F.; Fedorowicz, Adam; Jackson, Laurel G.; Frasch, H. Fred; Beezhold, Don; Munson, Albert E.; Meade, B. J.] NIOSH, Morgantown, WV 26505 USA. [Brown, Kenneth K.] NIOSH, Cincinnati, OH 45226 USA. RP Anderson, SE (reprint author), NIOSH, 1095 Willowdale Dr, Morgantown, WV 26505 USA. EM sanderson4@cdc.gov FU National Institute of Environmental Health Services-National Institute for Occupational Safety and Health Interagency Agreement [Y1-ES-0001]; Immunotoxicity of Workplace Xenobiotics FX Funding was received from National Institute of Environmental Health Services-National Institute for Occupational Safety and Health Interagency Agreement (Y1-ES-0001), Immunotoxicity of Workplace Xenobiotics. "The findings and conclusions in this report are those of the Author(s) and do not necessarily represent the views of the National Institute for Occupational Safety and Health." NR 29 TC 9 Z9 9 U1 1 U2 5 PU INFORMA HEALTHCARE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 1547-691X J9 J IMMUNOTOXICOL JI J. Immunotoxicol. PY 2009 VL 6 IS 1 BP 19 EP 29 DI 10.1080/15476910802604291 PG 11 WC Toxicology SC Toxicology GA 481HE UT WOS:000268797500003 PM 19519159 ER PT J AU Nielson, CM Schiaffino, MK Dunne, EF Salemi, JL Giuliano, AR AF Nielson, Carrie M. Schiaffino, Melody K. Dunne, Eileen F. Salemi, Jason L. Giuliano, Anna R. TI Associations between Male Anogenital Human Papillomavirus Infection and Circumcision by Anatomic Site Sampled and Lifetime Number of Female Sex Partners SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID CERVICAL-CANCER; PENILE CANCER; UNITED-STATES; RISK-FACTORS; MEN; PREVALENCE; DETERMINANTS; METAANALYSIS; DISEASE; WOMEN AB Background. Male circumcision may lower men's risk of human papillomavirus (HPV) infection and reduce transmission to sex partners. Reported associations between circumcision and HPV infection in men have been inconsistent. Methods. Four hundred sixty-three men in 2 US cities were tested at 6 anogenital sites and in semen for 37 types of HPV. Men were eligible if they reported sex with a woman within the past year, no history of genital warts or penile or anal cancer, and no current diagnosis of a sexually transmitted infection. Participants completed a self-administered questionnaire. Circumcision status was assessed by the study clinician. Logistic regression was used to examine associations between circumcision and HPV detection at each site and in semen, with adjustment for potential confounders. Results. Seventy-four men (16.0%) were uncircumcised. Adjusted odds ratios (AORs) for any HPV genotype and circumcision were 0.53 (95% confidence interval [CI], 0.28-0.99) for any anatomic site/specimen, 0.17 ( 95% CI, 0.05-0.56) for the urethra, 0.44 (95% CI, 0.23-0.82) for the glans/corona, and 0.53 ( 95% CI, 0.28-0.99) for the penile shaft. AORs were <1.0 but not statistically significant for the scrotum, semen, anal canal, and perianal area. Conclusions. Circumcision may be protective against HPV infection of the urethra, glans/corona, and penile shaft. C1 [Giuliano, Anna R.] H Lee Moffitt Canc Ctr & Res Inst, Risk Assessment Detect & Intervent Program, MRC CANCONT, Tampa, FL 33612 USA. [Nielson, Carrie M.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Dunne, Eileen F.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA USA. RP Giuliano, AR (reprint author), H Lee Moffitt Canc Ctr & Res Inst, Risk Assessment Detect & Intervent Program, MRC CANCONT, 12902 Magnolia Dr, Tampa, FL 33612 USA. EM anna.giuliano@moffitt.org OI Salemi, Jason/0000-0002-0077-6023 FU Centers for Disease Control and Prevention; Association of American Medical Colleges [U36/CCU319276, MM-0579-03/ 03]; National Cancer Institute [R25 CA078447] FX Financial support: This project was supported under a cooperative agreement from the Centers for Disease Control and Prevention through the Association of American Medical Colleges (grant U36/CCU319276; AAMC ID no. MM-0579-03/ 03). C. M. N. was supported by the National Cancer Institute (grant R25 CA078447). NR 24 TC 47 Z9 51 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JAN 1 PY 2009 VL 199 IS 1 BP 7 EP 13 DI 10.1086/595567 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 384OP UT WOS:000261754400003 PM 19086813 ER PT J AU Warner, L Ghanem, KG Newman, DR Macaluso, M Sullivan, PS Erbelding, EJ AF Warner, Lee Ghanem, Khalil G. Newman, Daniel R. Macaluso, Maurizio Sullivan, Patrick S. Erbelding, Emily J. TI Male Circumcision and Risk of HIV Infection among Heterosexual African American Men Attending Baltimore Sexually Transmitted Disease Clinics SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT 39th Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 21-24, 2006 CL Seattle, WA SP Soc Epidemiol Res ID LONGITUDINAL DATA-ANALYSIS; SIMPLEX-VIRUS TYPE-2; CONDOM EFFECTIVENESS; UNITED-STATES; NATIONAL-HEALTH; TARGET-CELLS; TRANSMISSION; SEROCONVERSION; PREVALENCE; PREVENTION AB Background. Male circumcision has received international attention as an intervention for reducing HIV infection among high-risk heterosexual men; however, few US studies have evaluated its association with the risk of HIV infection. Methods. We analyzed visit records for heterosexual African American men who underwent HIV testing while attending sexually transmitted disease (STD) clinics in Baltimore, Maryland, from 1993 to 2000. We used multivariable binomial regression to evaluate associations between circumcision and the risk of HIV infection among visits by patients with known and unknown HIV exposure. Results. Overall, 1096 (2.7%) of 40,571 clinic visits yielded positive HIV test results. Among 394 visits by patients with known HIV exposure, circumcision was significantly associated with lower HIV prevalence (10.2% vs. 22.0%; adjusted prevalence rate ratio [PRR], 0.49 [95% confidence interval [CI], 0.26-0.93]). Conversely, among 40,177 visits by patients with unknown HIV exposure, circumcision was not associated with reduced HIV prevalence (2.5% vs. 3.3%; adjusted PRR, 1.00 [95% CI, 0.86-1.15]), and age >= 25 years old and diagnosis of ulcerative STD were associated with increased prevalence. Conclusions. Circumcision was associated with substantially reduced HIV risk in patients with known HIV exposure, suggesting that results of other studies demonstrating reduced HIV risk for circumcision among heterosexual men likely can be generalized to the US context. C1 [Warner, Lee; Newman, Daniel R.; Macaluso, Maurizio] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA. [Newman, Daniel R.] Ctr Dis Control & Prevent, Div Sexually Transmitted Dis Prevent, Atlanta, GA 30341 USA. [Sullivan, Patrick S.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent Surveillance & Epidemiol, Atlanta, GA 30341 USA. [Ghanem, Khalil G.; Erbelding, Emily J.] Johns Hopkins Univ, Sch Med, Div Infect Dis, Baltimore, MD 21205 USA. [Erbelding, Emily J.] Baltimore City Dept Hlth, Baltimore, MD USA. RP Warner, L (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, 4770 Buford Hwy NE,Mail Stop K-34, Atlanta, GA 30341 USA. EM dlw7@cdc.gov RI Macaluso, Maurizio/J-2076-2015; OI Macaluso, Maurizio/0000-0002-2977-9690; Sullivan, Patrick/0000-0002-7728-0587 NR 38 TC 40 Z9 41 U1 0 U2 4 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JAN 1 PY 2009 VL 199 IS 1 BP 59 EP 65 DI 10.1086/595569 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 384OP UT WOS:000261754400009 PM 19086815 ER PT J AU Lauth, X von Kockritz-Blickwede, M McNamara, CW Myskowski, S Zinkernagel, AS Beall, B Ghosh, P Gallo, RL Nizet, V AF Lauth, Xavier von Koeckritz-Blickwede, Maren McNamara, Case W. Myskowski, Sandra Zinkernagel, Annelies S. Beall, Bernard Ghosh, Partho Gallo, Richard L. Nizet, Victor TI M1 Protein Allows Group A Streptococcal Survival in Phagocyte Extracellular Traps through Cathelicidin Inhibition SO JOURNAL OF INNATE IMMUNITY LA English DT Article DE Group A Streptococcus; Streptococcus pyogenes; Virulence factor; Innate immunity; M protein; Neutrophil; Mast cell; Extracellular traps; Antimicrobial peptide; Cathelicidin ID SERUM OPACITY FACTOR; ANTIMICROBIAL PEPTIDES; FIBRONECTIN-BINDING; HUMAN NEUTROPHILS; SURFACE-PROTEINS; MOLECULAR-BASIS; PYOGENES; INFECTION; RESISTANCE; VIRULENCE AB M1 protein contributes to Group A Streptococcus (GAS) systemic virulence by interfering with phagocytosis and through proinflammatory activities when released from the cell surface. Here we identify a novel role of Mill protein in the stimulation of neutrophil and mast cell extracellular trap formation, yet also subsequent survival of the pathogen within these DNA-based innate defense structures. Targeted mutagenesis and heterologous expression studies demonstrate M1 protein promotes resistance to the human cathelicidin antimicrobial peptide LL-37, an important effector of bacterial killing within such phagocyte extracellular traps. Studies with purified recombinant protein fragments mapped the inhibition of cathelicidin killing to the M1 hypervariable N-terminal domain. A survey of GAS clinical isolates found that strains from patients with necrotizing fasciitis or toxic shock syndrome were significantly more likely to be resistant to cathelicidin than GAS M types not associated with invasive disease; M1 isolates were uniformly resistant. We conclude increased resistance to host cathelicidin and killing within phagocyte extracellular traps contribute to the propensity of M1 GAS strains to produce invasive infections. Copyright (C) 2009 S. Karger AG, Basel C1 [Lauth, Xavier; von Koeckritz-Blickwede, Maren; Myskowski, Sandra; Zinkernagel, Annelies S.; Gallo, Richard L.; Nizet, Victor] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA. [McNamara, Case W.; Ghosh, Partho] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA. [Gallo, Richard L.] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA. [Nizet, Victor] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA. [Beall, Bernard] Ctr Dis Control & Prevent, Resp Dis Branch, Div Bacterial Dis, Atlanta, GA USA. [Gallo, Richard L.] Vet Affairs San Diego Healthcare Ctr, San Diego, CA USA. [Nizet, Victor] Rady Childrens Hosp, San Diego, CA USA. RP Nizet, V (reprint author), Univ Calif San Diego, Dept Pediat, 9500 Gilman Dr,MC 0687, La Jolla, CA 92093 USA. EM vnizet@ucsd.edu RI Zinkernagel, Annelies/F-1780-2017; OI Gallo, Richard/0000-0002-1401-7861 FU NIH [A1048694, A1077780, AR45676, A148176, A1071167]; Wound Healing Foundation; Deutsche Akademie der Naturforscher Leopoldina [BMBF-LPD 9901/8-187] FX This work was Supported by NIH grants A1048694 and A1077780 (V.N.), AR45676 and A148176 (R.L.G.), and A1071167 (P.G.). X.L. was supported by a Wound Healing Foundation fellowship Award and M.v.K.-B. was supported through a fellowship from the Deutsche Akademie der Naturforscher Leopoldina (BMBF-LPD 9901/8-187). NR 54 TC 85 Z9 86 U1 0 U2 8 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1662-811X EI 1662-8128 J9 J INNATE IMMUN JI J. Innate Immun. PY 2009 VL 1 IS 3 BP 202 EP 214 DI 10.1159/000203645 PG 13 WC Immunology SC Immunology GA 471XI UT WOS:000268091300005 PM 20375578 ER PT J AU Goodman, RA AF Goodman, Richard A. TI The Dangerous Infected Patient SO JOURNAL OF LEGAL MEDICINE LA English DT Article; Proceedings Paper CT 10th Annual Southern Illinois Healthcare Conference CY MAY 16, 2008 CL Carbondale, IL SP So Illinois Univ Hlth Policy Inst ID HEPATITIS-B; CARRIER STATE; MICHIGAN; AGE C1 Ctr Dis Control & Prevent, Off Strategy & Innovat, Publ Hlth Law Program, Atlanta, GA 30333 USA. RP Goodman, RA (reprint author), Ctr Dis Control & Prevent, Off Strategy & Innovat, Publ Hlth Law Program, Mailstop D-30,1600 Clifton Rd, Atlanta, GA 30333 USA. EM rag4@cdc.gov NR 21 TC 1 Z9 1 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0194-7648 J9 J LEGAL MED JI J. Legal Med. PY 2009 VL 30 IS 1 BP 13 EP 26 AR PII 909036344 DI 10.1080/01947640802694544 PG 14 WC Law; Social Sciences, Biomedical SC Government & Law; Biomedical Social Sciences GA 412HO UT WOS:000263716100002 PM 19241271 ER PT J AU Hoover, K Koumans, EH Montano, D Kasprzyk, D Freeman, C Greek, A Jain, N Irwin, K AF Hoover, Karen Koumans, Emilia H. Montano, Daniel Kasprzyk, Danuta Freeman, Crystal Greek, Apird Jain, Nidhi Irwin, Kathleen TI Access of Black, Hispanic, and Nonprivately Insured Women to Liquid-Based Cytology, Human Papillomavirus DNA Testing, and On-Site Colposcopy in the United States SO JOURNAL OF LOWER GENITAL TRACT DISEASE LA English DT Article DE access; Pap test; liquid-based cytology; HPV test; colposcopy ID ATYPICAL SQUAMOUS-CELLS; EARLY-DETECTION PROGRAM; CANCER SCREENING-TESTS; CERVICAL-CANCER; COST-EFFECTIVENESS; ETHNIC-DIFFERENCES; NATIONAL BREAST; HEALTH-CARE; FOLLOW-UP; MANAGEMENT AB Objective. To determine whether patient race, ethnicity, or insurance status was associated with access to cervical cancer screening with liquid-based cytology (LBC) and with human papillomavirus (HPV) DNA testing and with access to on-site colposcopy at the provider's principal practice site. Materials and Methods. We conducted a nationally representative survey of clinicians in specialties that provide cervical cancer screening. Adjusted odds ratios (OR) were estimated for the associations between race, ethnicity, and insurance status of patients and provider use of LBC, HPV DNA testing, and on-site colposcopy. Results. Providers who cared for >= 20% Hispanic patients were less likely to use LBC (OR 0.60, 95% CI = 0.42-0.84). Providers who cared for >= 25% black women (OR 0.71, 95% CI = 0.51-0.98) and providers who cared for <75% privately insured patients (OR 0.66, 95% Cl = 0.46-0.95) were less likely to use HPV DNA testing. Providers who cared for <75% privately insured patients were less likely to have on-site colposcopy (OR 0.57, 95% CI = 0.37-0.89), but those who cared for >= 20% Medicaid patients were more likely to have on-site colposcopy (OR 1,86, 95% CI = 1.26-2.73). Conclusions. Given the high rates of cervical cancer in minority women, access to cervical cancer screening and diagnostic follow-up must be ensured. It may also be beneficial to ensure affordable access to technologies such HPV DNA testing that increases the sensitivity of disease detection and to on-site colposcopy that facilitates follow-up of abnormal cytology. C1 [Hoover, Karen] Ctr Dis Control & Prevent, Div Sexually Transmitted Dis Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preve, Atlanta, GA 30333 USA. [Montano, Daniel; Kasprzyk, Danuta; Freeman, Crystal; Greek, Apird] Battelle Ctr Publ Hlth Res & Evaluat, Seattle, WA USA. RP Hoover, K (reprint author), Ctr Dis Control & Prevent, Div Sexually Transmitted Dis Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preve, 1600 Clifton Rd NE,MS E-80, Atlanta, GA 30333 USA. EM khoover@cdc.gov FU NICHD NIH HHS [R24 HD042828, R24 HD042828-10] NR 46 TC 2 Z9 2 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1089-2591 J9 J LOW GENIT TRACT DI JI J. Low. Genit. Tract. Dis. PD JAN PY 2009 VL 13 IS 1 BP 17 EP 27 PG 11 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 390MX UT WOS:000262169500005 PM 19098602 ER PT J AU Dauphin, LA Moser, BD Bowen, MD AF Dauphin, Leslie A. Moser, Benjamin D. Bowen, Michael D. TI Evaluation of five commercial nucleic acid extraction kits for their ability to inactivate Bacillus anthracis spores and comparison of DNA yields from spores and spiked environmental samples SO JOURNAL OF MICROBIOLOGICAL METHODS LA English DT Article DE Bacillus anthracis; Bacillus anthracis spores; DNA extraction; Bioterrorism ID REAL-TIME PCR; BIOLOGICAL TERRORISM; SUBTILIS SPORES; RAPID DETECTION; NASAL SWABS; BIOTERRORISM; RECOVERY; AGENTS; ASSAY; PURITY AB This study evaluated five commercial extraction kits for their ability to recover DNA from Bacillus anthracis spores and spiked environmental samples. The kits evaluated represent the major types of methodologies which are commercially available for DNA or total nucleic acid extraction, and included the ChargeSwitch gDNA Mini Bacteria Kit, NucliSens Isolation Kit, Puregene Genomic DNA Purification Kit, QIAamp DNA Blood Mini Kit, and the UltraClean Microbial DNA Isolation Kit. Extraction methods were performed using the spores of eight virulent strains of B. anthracis. Viability testing of nucleic acid extracts showed that the UltraClean kit was the most efficient at depleting samples of live B. anthracis spores. TaqMan real-time PCR analysis revealed that the NucliSens, QIAamp and Ultraclean kits yielded the best level of detection from spore suspensions. Comparisons of processed samples from spiked swabs and three powder types indicated that DNA extraction using the UltraClean kit resulted in the most consistently positive results and the lowest limit of detection. This study demonstrated that different nucleic extraction methodologies, represented here by various commercial extraction kits, differ in their ability to inactivate live B. anthracis spores as well as DNA yield and purity. In addition, the extraction method used can influence the sensitivity of real-time PCR assays for B. anthracis. Published by Elsevier B.V. C1 [Dauphin, Leslie A.; Moser, Benjamin D.; Bowen, Michael D.] CDC, BRRAT Lab, DBPR, NCPDCID, Atlanta, GA 30333 USA. RP Dauphin, LA (reprint author), CDC, BRRAT Lab, DBPR, NCPDCID, Mail Stop G-42,1600 Clifton Rd, Atlanta, GA 30333 USA. EM Ldauphin@CDC.GOV NR 31 TC 38 Z9 39 U1 0 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-7012 J9 J MICROBIOL METH JI J. Microbiol. Methods PD JAN PY 2009 VL 76 IS 1 BP 30 EP 37 DI 10.1016/j.mimet.2008.09.004 PG 8 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA 396DN UT WOS:000262572500006 PM 18824041 ER PT J AU Biernath, K Holstrum, J Eichwald, J AF Biernath, Krista Holstrum, June Eichwald, John TI Hearing Screening for Newborns: The Midwife's Role in Early Hearing Detection and Intervention SO JOURNAL OF MIDWIFERY & WOMENS HEALTH LA English DT Article DE hearing; midwifery; neonatal screening; newborn ID POSITION STATEMENT; IMPAIRMENT; PRINCIPLES; GUIDELINES; INFECTION; PROGRAMS; CHILDREN AB Universal newborn hearing screening is becoming the standard of care in the United States. However, there has been some controversy around this pediatric preventive health care practice. In 2001, the US Preventative Services Task Force (USPSTF), the leading independent panel of experts on prevention and primary care in the United States, reviewed the scientific literature and found inconclusive evidence to recommend for or against universal newborn hearing screening. As a result of this lack of recommendation, some pediatric providers were not screening the hearing of all newborn infants. The USPSTF released an update in July 2008 concluding there is scientific evidence to recommend newborn hearing screening for all infants. Universal newborn hearing screening is the first step in the national Early Hearing Detection and Intervention (EHDI) program. EHDI includes not only universal newborn hearing screening but also diagnostic evaluation for any infant failing the initial hearing screen and intervention services for any infant diagnosed with hearing loss. During the prenatal and postnatal periods, obstetric care providers can play a vital role in the EHDI process through education, screening, referral, and assistance with follow-up. Through these services, clinicians can work with parents and pediatric care providers to help newborns and infants develop communication and language skills that will last a lifetime. J Midwifery Womens Health 2009;54:18-26 (C) 2009 by the American College of Nurse-Midwives. C1 [Biernath, Krista] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Early Hearing Detect & Intervent Team, Early Hearing Detect & Intervent Program, Atlanta, GA 30333 USA. RP Biernath, K (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Early Hearing Detect & Intervent Team, Early Hearing Detect & Intervent Program, Mailstop E-88,1600 Clifton Rd, Atlanta, GA 30333 USA. EM kbiernath@cdc.gov RI Sandall, Jane/D-4146-2009 OI Sandall, Jane/0000-0003-2000-743X NR 37 TC 4 Z9 5 U1 1 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1526-9523 J9 J MIDWIFERY WOM HEAL JI J. Midwifery Women Health PD JAN-FEB PY 2009 VL 54 IS 1 BP 18 EP 26 DI 10.1016/j.jmwh.2008.07.019 PG 9 WC Nursing SC Nursing GA 392HG UT WOS:000262293200004 PM 19114235 ER PT J AU He, XQ Kan, H Cai, L Ma, Q AF He, Xiaoqing Kan, Hong Cai, Lu Ma, Qiang TI Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes SO JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY LA English DT Article DE Nrf2; Diabetic cardiomyopathy; Reactive oxygen species; Oxidative stress; Antioxidant; Glucose ID TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT RESPONSE ELEMENT; MITOCHONDRIAL ROS PRODUCTION; GLYCATION END-PRODUCTS; INSULIN-RESISTANCE; NAD(P)H-QUINONE OXIDOREDUCTASE; GENE-EXPRESSION; MICE LACKING; STRESS; RECEPTOR AB Exposure to high levels of glucose induces the production of reactive oxygen species (ROS) in cardiomyocytes that may contribute to the development of cardiomyopathy in diabetes. Nuclear factor erythroid 2-related factor 2 (Nrf2) controls the antioxidant response element (ARE)-dependent gene regulation in response to oxidative stress. The role of Nrf2 in defense against high glucose-induced oxidative damage in cardiomyocytes was investigated. Glucose at high concentrations induced ROS production in both primary neonatal and adult cardiomyocytes from the Nrf2 wild type (WT) mouse heart, whereas, in Nrf2 knockout (KO) cells, ROS was significantly higher under basal conditions and high glucose markedly further increased ROS production in concentration and time-dependent manners. Concomitantly, high glucose induced significantly higher levels of apoptosis at lower concentrations and in shorter time in Nrf2 KO cells than in WT cells. Primary adult cardiomyocytes from control and diabetic mice also showed dependence on Nrf2 function for isoproterenol-stimulated contraction. Additionally, cardiomyocytes from Nrf2 KO mice exhibited increased sensitivity to 3-nitropropionic acid, an inhibitor of mitochondrial respiratory complex 11, for both ROS production and apoptosis compared with Nrf2 WT cells, further emphasizing the role of Nrf2 in ROS defense in the cells. Mechanistically, Nrf2 was shown to mediate the basal expression and induction of ARE-controlled cytoprotective genes, Nqo1 and Ho1, at both mRNA and protein levels in cardiomyocytes, as both the basal and inducible expressions of the genes were lost in Nrf2 KO cells or largely reduced by Nrf2 SiRNA. The findings, for the first time, established Nrf2 as a critical regulator of defense against ROS in normal and diabetic hearts. Published by Elsevier Inc. C1 [He, Xiaoqing; Ma, Qiang] Ctr Dis Control & Prevent, Receptor Biol Lab, Toxicol & Mol Biol Branch, Hlth Effects Lab Div,Natl Inst Occupat Safety & H, Morgantown, WV 26505 USA. [Kan, Hong] W Virginia Univ, Dept Med, Sch Med, Morgantown, WV 26506 USA. [Cai, Lu] Univ Louisville, Sch Med, Dept Med, Louisville, KY 40292 USA. RP Ma, Q (reprint author), Ctr Dis Control & Prevent, Receptor Biol Lab, Toxicol & Mol Biol Branch, Hlth Effects Lab Div,Natl Inst Occupat Safety & H, Mailstop 3014,1095 Willowdale Rd, Morgantown, WV 26505 USA. EM 10cai001@louisville.edu; qam1@cdc.gov NR 43 TC 104 Z9 117 U1 1 U2 15 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0022-2828 EI 1095-8584 J9 J MOL CELL CARDIOL JI J. Mol. Cell. Cardiol. PD JAN PY 2009 VL 46 IS 1 BP 47 EP 58 DI 10.1016/j.yjmcc.2008.10.007 PG 12 WC Cardiac & Cardiovascular Systems; Cell Biology SC Cardiovascular System & Cardiology; Cell Biology GA 394WC UT WOS:000262482800007 PM 19007787 ER PT J AU Strine, TW Kroenke, K Dhingra, S Balluz, LS Gonzalez, O Berry, JT Mokdad, AH AF Strine, Tara W. Kroenke, Kurt Dhingra, Satvinder Balluz, Lina S. Gonzalez, Olinda Berry, Joyce T. Mokdad, Ali H. TI The Associations Between Depression, Health-Related Quality of Life, Social Support, Life Satisfaction, and Disability in Community-Dwelling US Adults SO JOURNAL OF NERVOUS AND MENTAL DISEASE LA English DT Article DE Depression; quality of life; life satisfaction; social support; disability; Patient Health Questionnaire 8 ID PRIMARY-CARE PATIENTS; MENTAL-DISORDERS; PRIME-MD; MAJOR DEPRESSION; UTILITY; QUESTIONNAIRE; VALIDITY; ANXIETY; PHQ-9; OUTPATIENTS AB The purpose of this manuscript is to describe the associations among current depression, as measured by the Patient Health Questionnaire 8, health-related quality of life, social support, life satisfaction, and disability status, using the 2006 Behavioral Risk Factor Surveillance System. A dose-response relationship exists between depression severity and mean number of days in the past 30 days of physical distress, pain, anxiety symptoms, and activity limitations as well as the prevalence of fair/poor general health, life dissatisfaction, inadequate social support, and disability. These profound associations underscore the need for recognition and treatment of depression in all healthcare settings. C1 [Strine, Tara W.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Atlanta, GA 30341 USA. [Kroenke, Kurt] Regenstrief Inst Hlth Care, Dept Med, Indianapolis, IN 46202 USA. [Kroenke, Kurt] Indiana Univ, Sch Med, Indianapolis, IN USA. [Gonzalez, Olinda; Berry, Joyce T.] Substance Abuse & Mental Hlth Serv Adm, Washington, DC USA. RP Strine, TW (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, 4770 Buford Highway NE,Mailstop K-66, Atlanta, GA 30341 USA. EM tws2@edc.gov NR 33 TC 68 Z9 69 U1 3 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-3018 J9 J NERV MENT DIS JI J. Nerv. Ment. Dis. PD JAN PY 2009 VL 197 IS 1 BP 61 EP 64 DI 10.1097/NMD.0b013e3181924ad8 PG 4 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 394KS UT WOS:000262446200010 PM 19155812 ER PT J AU Habib, AA Gilden, D Schmid, DS Safdieh, JE AF Habib, Ali A. Gilden, Don Schmid, D. Scott Safdieh, Joseph E. TI Varicella zoster virus meningitis with hypoglycorrhachia in the absence of rash in an immunocompetent woman SO JOURNAL OF NEUROVIROLOGY LA English DT Article DE varicella zoster; meningitis; hypoglycorrhachia; PCR; immunocompetent ID ACUTE ASEPTIC-MENINGITIS; HERPES-ZOSTER; CEREBROSPINAL-FLUID; IMMUNOFLUORESCENT DEMONSTRATION; ADULT-POPULATION; NERVOUS-SYSTEM; CSF CELLS; PATIENT; MENINGOENCEPHALITIS; ENCEPHALITIS AB We report varicella-zoster virus (VZV) meningitis in a healthy adult woman with no antecedent rash and with hypoglycorrhachia. Cerebrospinal fluid (CSF) examination revealed the presence of VZV DNA, anti-VZV immunoglobulin G (IgG) antibody, and intrathecal production of anti-VZV IgG antibody. C1 [Gilden, Don] Univ Colorado, Denver Sch Med, Dept Neurol, Aurora, CO 80045 USA. [Gilden, Don] Univ Colorado, Denver Sch Med, Dept Microbiol, Aurora, CO 80045 USA. [Habib, Ali A.; Safdieh, Joseph E.] New York Presbyterian Hosp, Weill Cornell Med Coll, Dept Neurol, New York, NY USA. [Schmid, D. Scott] Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Atlanta, GA USA. RP Gilden, D (reprint author), Univ Colorado, Denver Sch Med, Dept Neurol, Mail Stop B182,12700 E 19th Ave, Aurora, CO 80045 USA. EM don.gilden@ucdenver.edu FU National Institutes of Health [AG 006127, NS 32623] FX This work was supported in part by Public Health Service grants AG 006127 and NS 32623 from the National Institutes of Health. The authors thank Cathy Allen for preparing the manuscript. NR 31 TC 14 Z9 14 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1355-0284 J9 J NEUROVIROL JI J. Neurovirol. PY 2009 VL 15 IS 2 BP 206 EP 208 AR PII 909167464 DI 10.1080/13550280902725550 PG 3 WC Neurosciences; Virology SC Neurosciences & Neurology; Virology GA 444IO UT WOS:000265974400011 PM 19255900 ER PT J AU Hunsperger, EA Roehrig, JT AF Hunsperger, E. A. Roehrig, J. T. TI Nocodazole delays viral entry into the brain following footpad inoculation with West Nile virus in mice SO JOURNAL OF NEUROVIROLOGY LA English DT Article DE flavivirus; mice; nocodazole; West Nile virus ID CENTRAL-NERVOUS-SYSTEM; NEW-YORK-CITY; UNITED-STATES; BLOOD-TRANSFUSION; AXONAL-TRANSPORT; INFECTION; ENCEPHALITIS; STRAINS; POLIOMYELITIS; TRANSMISSION AB West Nile virus (WNV) infection in humans can cause neurological deficits, including flaccid paralysis, encephalitis, meningitis, and mental status change. To better understand the neuropathogenesis of WNV in the peripheral and the central nervous systems (PNS and CNS), we used a mouse footpad inoculation model to simulate a natural peripheral infection. Localization of WNV in the nervous system using this model has suggested two routes of viral invasion of the CNS: axonal retrograde transport (ART) from the PNS and hematogenous diffusion via a breakdown in the blood-choroid-plexus barrier. C57BL/6J mice were treated with nocodazole, a microtubule inhibitor that blocks ART, prior to infection with WNV. Nocodazole-treated WNV-infected mice developed a viremia 1.5 log(10) greater than untreated WNV-infected control mice at days 3 to 4 post infection ( PI). Although viremia was greater in nocodazole-treated mice, detection of virus in brain tissue (spinal cord, cortex, brainstem, and cerebellum), as measured by real-time reverse transcriptase-polymerase chain reaction (RT-PCR), did not occur until day 7. At these later time points (7 and 9 days PI), nocodazole-treated WNV-infected animals attained viral titers in these tissues similar to titers in the untreated WNV-infected control animals. These results demonstrate that a single dose of nocodazole delays, but does not block, WNV infection of the brain. Journal of NeuroVirology (2009) 15, 211-218. C1 [Hunsperger, E. A.] Ctr Dis Control & Prevent, Dengue Branch, San Juan, PR USA. [Roehrig, J. T.] Ctr Dis Control & Prevent, Ft Collins, CO USA. RP Hunsperger, EA (reprint author), Natl Ctr Infect Dis, Ctr Dis Control & Prevent CDC, Div Vector Borne Infect Dis, 1324 Calle Canada, San Juan, PR 00920 USA. EM enh4@cdc.gov OI Roehrig, John/0000-0001-7581-0479 NR 31 TC 5 Z9 5 U1 0 U2 1 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1355-0284 J9 J NEUROVIROL JI J. Neurovirol. PY 2009 VL 15 IS 3 BP 211 EP 218 DI 10.1080/13550280902913255 PG 8 WC Neurosciences; Virology SC Neurosciences & Neurology; Virology GA 479SJ UT WOS:000268680900001 PM 19444694 ER PT J AU Ned, RM Dotson, WD Dowling, NF AF Ned, Renee M. Dotson, W. David Dowling, Nicole F. TI The Assessment of Diet-Genome Interactions and Their Translation for Public Health Impact: Opportunites and Challenges for the Centers for Disease Control and Prevention SO JOURNAL OF NUTRIGENETICS AND NUTRIGENOMICS LA English DT Meeting Abstract C1 [Ned, Renee M.; Dotson, W. David; Dowling, Nicole F.] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Natl Ctr Chron Dis Prevent & Hlth Promot, US Dept Hlth & Human Serv, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1661-6499 J9 J NUTRIGENET NUTRIGE JI J. Nutrigenet. Nutrigenomics PY 2009 VL 2 IS 4-5 BP 204 EP 204 PG 1 WC Genetics & Heredity; Nutrition & Dietetics SC Genetics & Heredity; Nutrition & Dietetics GA 610BD UT WOS:000278703300037 ER PT J AU Williams, CL Carter, BJ Kibbe, DL Dennison, D AF Williams, Christine L. Carter, Betty Jean Kibbe, Debra L. Dennison, David TI Increasing Physical Activity in Preschool: A Pilot Study to Evaluate Animal Trackers SO JOURNAL OF NUTRITION EDUCATION AND BEHAVIOR LA English DT Article DE children; physical activity; preschool; curriculum; school health ID FASTING PLASMA-INSULIN; HEALTHY-START; CHILDREN; CHILDHOOD; OBESITY; INTERVENTION; ADOLESCENCE; PREVALENCE; OVERWEIGHT; DIET AB Objective: This report describes a pilot study to evaluate Animal Trackers (AT), a preschool program designed to (1) increase Structured physical activity (PA) during the preschool day; (2) increase practice of gross motor skills; (3) provide teachers with an easy-to-use PA program regardless of teacher experience; and (4) implement a teacher walking intervention. Design: Pilot observational Study in volunteer preschools. Setting: Nine preschools in New Mexico. Participants: Two-hundred seventy 3- to 5-year-old children and 32 teachers. Intervention: Daily 10-minute classroom activities for children. Main Outcome Measure: Implementation and duration of AT activities, teacher preparation time, and added weekly time spent in Structured PA. Analysis: Process evaluation to track program implementation, and pre-post measures to assess outcomes. Results: AT activities were implemented 4.1 times per week (11.4 minutes/activity), with 7 minutes teacher preparation time. Overall, AT added 47 minutes of structured PA per week for children. Conclusions and Implications: The AT program increased structured PA time in preschools. Teachers felt that AT was developmentally appropriate; that children enjoyed the activities; and that the children's motor skills improved. Results of the pilot study are encouraging, since research suggests that even small increases in PA could help prevent obesity. C1 [Williams, Christine L.] Columbia Univ, Coll Phys & Surg, New York, NY USA. [Carter, Betty Jean] Strang Canc Prevent Ctr, New York, NY USA. [Kibbe, Debra L.] Int Life Sci Inst, Atlanta, GA USA. [Dennison, David] Ctr Dis Control, Atlanta, GA 30333 USA. RP Williams, CL (reprint author), Healthy Direct Inc, 428 E 72nd St,Ste 700, New York, NY 10021 USA. EM chrisw320@aol.com FU General Mills Champions Youth Nutrition and Fitness; HELP Head Start Program FX Funded by a General Mills Champions Youth Nutrition and Fitness Grant to the International Life Sciences Institute Center for Health Promotion (ILSI CHP) and the HELP Head Start Program (NM). NR 32 TC 19 Z9 19 U1 3 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1499-4046 J9 J NUTR EDUC BEHAV JI J. Nutr. Educ. Behav. PD JAN-FEB PY 2009 VL 41 IS 1 BP 47 EP 52 DI 10.1016/j.jneb.2008.03.004 PG 6 WC Education, Scientific Disciplines; Nutrition & Dietetics SC Education & Educational Research; Nutrition & Dietetics GA 400YC UT WOS:000262904300009 PM 19161920 ER PT J AU Power, ML Cogswell, ME Schulkin, J AF Power, M. L. Cogswell, M. E. Schulkin, J. TI US obstetrician-gynaecologist's prevention and management of obesity in pregnancy SO JOURNAL OF OBSTETRICS AND GYNAECOLOGY LA English DT Article DE Maternal obesity; BMI; caesarean birth; clinical practice guidelines ID AMBULATORY RESEARCH NETWORK; OUTPATIENT OBSTETRICS AB A survey regarding management of obesity in pregnancy was mailed to 787 practising members of the American College of Obstetricians and Gynecologists (ACOG); 433 responded of whom 353 practised obstetrics. Most (79.2%) had read ACOG Committee Opinion, 'Obesity in Pregnancy,' and rated it helpful (68.6%) or very helpful (17.2%). Most responding physicians (91.2%) use BMI to assess their patients weight status; fewer (63.4%) use pre-pregnancy BMI to modify their pregnancy weight gain recommendation. Having read the Committee Opinion and being a woman were independent factors associated with using pre-pregnancy BMI. Responding physicians that had read the Committee Opinion were more knowledgeable about obesity-related pregnancy complications; but even among those physicians, only 32.2% were aware that maternal obesity is a risk factor for fetal neural tube defects. The responding physicians appeared well-versed on appropriate practice for caesarean delivery for obese patients whether they had read the Committee Opinion or not. C1 [Power, M. L.; Schulkin, J.] Amer Coll Obstetricians & Gynecologists, Res Dept, Washington, DC 20024 USA. [Cogswell, M. E.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Power, ML (reprint author), Amer Coll Obstetricians & Gynecologists, Res Dept, 409 12th St SW, Washington, DC 20024 USA. EM mpower@acog.org OI Power, Michael/0000-0002-6120-3528 FU Maternal and Child Health Bureau [R60 MC 05674]; Health Resources and Services Administration; Department of Health and Human Services; Centers for Disease Control and Prevention, Atlanta GA FX Supported by Grant R60 MC 05674 from Maternal and Child Health Bureau (Title V, Social Security Act), Health Resources and Services Administration, Department of Health and Human Services and grant support from the Centers for Disease Control and Prevention, Atlanta GA. NR 10 TC 15 Z9 15 U1 0 U2 1 PU INFORMA HEALTHCARE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 0144-3615 J9 J OBSTET GYNAECOL JI J. Obstet. Gynaecol. PY 2009 VL 29 IS 5 BP 373 EP 377 AR PII 913140768 DI 10.1080/01443610902946911 PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 470MS UT WOS:000267979400002 PM 19603311 ER PT J AU Coffey, CC Pearce, TA Lawrence, RB Hudnall, JB Slaven, JE Martin, SB AF Coffey, Christopher C. Pearce, Terri A. Lawrence, Robert B. Hudnall, Judith B. Slaven, James E. Martin, Stephen B., Jr. TI Measurement Capability of Field Portable Organic Vapor Monitoring Instruments Under Different Experimental Conditions SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE direct-reading organic vapor monitors; gases; performance ID PHOTOIONIZATION DETECTORS; EXPOSURE AB The performance of field portable direct-reading organic vapor monitors (DROVMs) was evaluated under a variety of experimental conditions. Four of the DROVMs had photoionization detectors (ppbRAE, IAQRAE, MultiRAE, and Century Toxic Vapor Analyzer), one had a flame ionization detector ( Century Toxic Vapor Analyzer), and one was a single-beam infrared spectrophotometer (SapphIRe). Four of each DROVM (two Century Toxic Vapor Analyzers and SapphIRes) were tested. The DROVMs were evaluated at three temperatures (4 degrees C, 21 degrees C, and 38 degrees C), three relative humidities (30%, 60%, and 90%), and two hexane concentrations (5 ppm and 100 ppm). These conditions were selected to provide a range within the operational parameters of all the instruments. At least four replicate trials were performed across the 18 experimental conditions ( 3 temperatures x 3 relative humidities x 2 concentrations). To evaluate performance, the 4-hr time-weighted average readings from the DROVMs in a given trial were compared with the average of two charcoal tube concentrations using pairwise comparison. The pairwise comparison criterion was +/- 25% measurement agreement between each individual DROVM and the DROVMs as a group and the average charcoal tube concentration. The ppbRAE group performed the best with 40% of all readings meeting the comparison criterion followed by the SapphIRe group at 39%. Among individual DROVMs, the best performer was a SapphIRe, with 57% of its readings meeting the criterion. The data was further analyzed by temperature, humidity, and concentration. The results indicated the performance of some DROVMs may be affected by temperature, humidity, and/or concentration. The ppbRAE group performed best at 21 degrees C with the percentage of readings meeting the criterion increasing to 63%. At the 5 ppm concentration, 44% of the ppbRAE group readings met the criterion, while at 100 ppm, only 35% did. The results indicate that monitors can be used as survey tools. Based on the data, the inconsistent performance of these DROVMs may not allow them to be used for determining compliance with occupational exposure limits. C1 [Coffey, Christopher C.; Pearce, Terri A.; Lawrence, Robert B.; Hudnall, Judith B.; Slaven, James E.; Martin, Stephen B., Jr.] NIOSH, Dept Hlth & Human Serv Publ Hlth Serv, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. RP Coffey, CC (reprint author), NIOSH, Dept Hlth & Human Serv Publ Hlth Serv, Ctr Dis Control & Prevent, 1095 Willowdale Rd, Morgantown, WV 26505 USA. EM ccoffey@cdc.gov RI Coffey, Christopher/I-2471-2012 FU Deborah Sbarra FX The authors acknowledge Deborah Sbarra for her assistance in collecting the data. NR 7 TC 10 Z9 10 U1 3 U2 11 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1545-9624 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2009 VL 6 IS 1 BP 1 EP 8 DI 10.1080/15459620802514728 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 381BC UT WOS:000261508800001 PM 18949604 ER PT J AU Heitbrink, WA Evans, DE Ku, BK Maynard, AD Slavin, TJ Peters, TM AF Heitbrink, William A. Evans, Douglas E. Ku, Bon Ki Maynard, Andrew D. Slavin, Thomas J. Peters, Thomas M. TI Relationships Among Particle Number, Surface Area, and Respirable Mass Concentrations in Automotive Engine Manufacturing SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE active surface area concentration; comparison between exposure metrics; respirable mass concentration; ultrafine number concentration ID LOW-PRESSURE IMPACTOR; ULTRAFINE PARTICLES; ASSEMBLY FACILITY; MOBILITY ANALYSIS; MACHINING CENTER; AEROSOL; EXPOSURE; FINE; GAS; ELPI AB This study investigated the relationships between particle number, surface area, and respirable mass concentration measured simultaneously in a foundry and an automotive engine machining and assembly center. Aerosol concentrations were measured throughout each plant with a condensation particle counter for number concentration, a diffusion charger for active surface area concentration, and an optical particle counter for respirable mass concentration. At selected locations, particle size distributions were characterized with the optical particle counter and an electrical low pressure impactor. Statistical analyses showed that active surface area concentration was correlated with ultrafine particle number concentration and weakly correlated with respirable mass concentration. Correlation between number and active surface area concentration was stronger during winter (R(2) = 0.6 for both plants) than in the summer (R(2) = 0.38 and 0.36 for the foundry and engine plant respectively). The stronger correlation in winter was attributed to use of direct-fire gas fired heaters that produced substantial numbers of ultrafine particles with a modal diameter between 0.007 and 0.023 mu m. These correlations support findings obtained through theoretical analysis. Such analysis predicts that active surface area increasingly underestimates geometric surface area with increasing particle size, particularly for particles larger than 100 nm. Thus, a stronger correlation between particle number concentration and active surface area concentration is expected in the presence of high concentrations of ultrafine particles. In general, active surface area concentration may be a concentration metric that is distinct from particle number concentration and respirable mass concentration. For future health effects or toxicological studies involving nano-materials or ultrafine aerosols, this finding needs to be considered, as exposure metrics may influence data interpretation. C1 [Heitbrink, William A.; Peters, Thomas M.] Univ Iowa, Dept Occupat & Environm Hlth, Iowa City, IA 52242 USA. [Evans, Douglas E.; Ku, Bon Ki] NIOSH, Div Appl Res & Technol, Cincinnati, OH 45226 USA. [Maynard, Andrew D.] Woodrow Wilson Int Ctr Scholars, Washington, DC 20560 USA. [Slavin, Thomas J.] Int Truck & Engine Corp, Warrenville, IL USA. RP Heitbrink, WA (reprint author), Univ Iowa, Dept Occupat & Environm Hlth, 102 IREH,100 Oakdale Campus, Iowa City, IA 52242 USA. EM william-heitbrink@uiowa.edu RI Maynard, Andrew/D-1076-2010; OI Maynard, Andrew/0000-0003-2117-5128 NR 40 TC 56 Z9 56 U1 0 U2 20 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1545-9624 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2009 VL 6 IS 1 BP 19 EP 31 DI 10.1080/15459620802530096 PG 13 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 381BC UT WOS:000261508800003 PM 18982535 ER PT J AU Ashley, K Ekechukwu, A AF Ashley, Kevin Ekechukwu, Amy TI Proceedings of the Third International Symposium on Beryllium Particulates and Their Detection November 17-19, 2008, Albuquerque, New Mexico SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Editorial Material C1 [Ashley, Kevin] NIOSH, Cincinnati, OH 45226 USA. [Ekechukwu, Amy] Savannah River Natl Lab, Aiken, SC USA. RP Ashley, K (reprint author), NIOSH, Cincinnati, OH 45226 USA. RI Ashley, Kevin/C-9005-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1545-9624 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2009 VL 6 IS 12 BP 89 EP 90 AR PII 916671120 DI 10.1080/15459620903158607 PG 2 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 517WQ UT WOS:000271650100001 PM 28125333 ER PT J AU Ashley, K Braybrooke, G Jahn, SD Brisson, MJ White, KT AF Ashley, Kevin Braybrooke, Geoffrey Jahn, Steven D. Brisson, Michael J. White, Kenneth T. TI Analytical Performance Criteria SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article; Proceedings Paper CT 3rd Symposium on Beryllium Particulates and their Detection CY NOV 17-19, 2008 CL Univ New Mexico, Albuquerque, NM HO Univ New Mexico ID SURFACE CONTAMINATION; COLLECTION; EXPOSURE; DUST; SKIN; LEAD C1 [Ashley, Kevin] Ctr Dis Control & Prevent, US Dept Hlth & Human Serv, NIOSH, Cincinnati, OH USA. [Braybrooke, Geoffrey] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. [Jahn, Steven D.; Brisson, Michael J.] Savannah River Nucl Solut, Aiken, SC USA. [White, Kenneth T.] Consult Serv, Virginia Beach, VA USA. RP Ashley, K (reprint author), Ctr Dis Control & Prevent, US Dept Hlth & Human Serv, NIOSH, Cincinnati, OH USA. RI Ashley, Kevin/C-9005-2011 NR 24 TC 3 Z9 3 U1 1 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1545-9624 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2009 VL 6 IS 12 BP 97 EP 100 AR PII 916670748 DI 10.1080/15459620903022597 PG 4 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 517WQ UT WOS:000271650100003 ER PT J AU Tak, S Paquet, V Woskie, S Buchholz, B Punnett, L AF Tak, SangWoo Paquet, Victor Woskie, Susan Buchholz, Bryan Punnett, Laura TI Variability in Risk Factors for Knee Injury in Construction SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE kneeling; manual material handling; random effect models; squatting; variance ratio ID EXPOSURE ASSESSMENT STRATEGIES; OCCUPATIONAL-EXPOSURE; HIGHWAY CONSTRUCTION; PHYSICAL DEMANDS; POSTURAL LOAD; FLOOR LAYERS; WORK; OSTEOARTHRITIS; DISORDERS; HIP AB This study investigated sources of variance in exposure to risk factors for knee pain in a variety of highway construction trades, operations, and tasks. Over 15,000 discrete observations of leg postures and weights handled were made on 120 construction workers in five construction trades, in nine operations over 79 days. The contributions of trade, operation, task, and worker to the variability in work time spent kneeling, squatting, and carrying loads were evaluated with multilevel random effects models. Construction operation and task explained about 20% to 30% of total variation in kneeling, squatting, and carrying loads. There was a large unexplained component of variance thought to represent day-to-day variability of exposure within task. Reliable assessments of knee exposures require multiple days to accommodate the high variability of exposures among operations and tasks and over time. These sources of variability should be carefully considered in efforts to estimate exposures to knee loading for epidemiologic or intervention studies. Homogenous exposure groups are not easily defined from the readily available organizational features of construction work. C1 [Paquet, Victor] SUNY Buffalo, Dept Ind & Syst Engn, Buffalo, NY 14260 USA. [Tak, SangWoo; Woskie, Susan; Buchholz, Bryan; Punnett, Laura] Univ Massachusetts Lowell, Dept Work Environm, Lowell, MA USA. RP Tak, S (reprint author), NIOSH, Div Surveillance Hazard Evaluat & Field Studies, 4676 Columbia Pkwy,R-17, Cincinnati, OH 45226 USA. EM stak@cdc.gov FU National Institute for Occupational Safety and Health [UO2/CCU30877103]; Harvard-NIOSH Education and Research Center [T42 CCT 122961-02] FX T he Center to Protect Workers' Rights supported this research with a grant provided by the National Institute for Occupational Safety and Health ( grant # UO2/CCU30877103). Research support was also provided by a pilot project grant awarded by the Harvard-NIOSH Education and Research Center under grant T42 CCT 122961-02. The authors are grateful for the cooperation of the construction workers who participated in the study. NR 36 TC 7 Z9 7 U1 1 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1545-9624 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2009 VL 6 IS 2 BP 113 EP 120 DI 10.1080/15459620802615822 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 398ID UT WOS:000262724900001 PM 19085603 ER PT J AU Zaebst, DD Seel, EA Yiin, JH Nowlin, SJ Chen, P AF Zaebst, D. D. Seel, E. A. Yiin, J. H. Nowlin, S. J. Chen, P. TI Summary of Retrospective Asbestos and Welding Fume Exposure Estimates for a Nuclear Naval Shipyard and Their Correlation with Radiation Exposure Estimates SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE confounding; exposure assessment; lung cancer ID LOCALLY WEIGHTED REGRESSION; IONIZING-RADIATION; LUNG-CANCER; WORKERS; MORTALITY; LEUKEMIA; HEALTH; RISK AB In support of a nested case-control study at a U. S. naval shipyard, the results of the reconstruction of historical exposures were summarized, and an analysis was undertaken to determine the impact of historical exposures to potential chemical confounders. The nested case-control study (N = 4388) primarily assessed the relationship between lung cancer and external ionizing radiation. Chemical confounders considered important were asbestos and welding fume (as iron oxide fume), and the chromium and nickel content of welding fume. Exposures to the potential confounders were estimated by an expert panel based on a set of quantitatively defined categories of exposure. Distributions of the estimated exposures and trends in exposures over time were examined for the study population. Scatter plots and Spearman rank correlation coefficients were used to assess the degree of association between the estimates of exposure to asbestos, welding fume, and ionizing radiation. Correlation coefficients were calculated separately for 0-, 15-, 20-, and 25-year time-lagged cumulative exposures, total radiation dose (which included medical X-ray dose) and occupational radiation dose. Exposed workers' estimated cumulative exposures to asbestos ranged from 0.01 fiber-days/cm(3) to just under 20,000 fiber-days/cm(3), with a median of 29.0 fiber-days/cm(3). Estimated cumulative exposures to welding fume ranged from 0.16 mgdays/m(3) to just over 30,000 mg-days/m(3), with a median of 603 mg-days/m(3). Spearman correlation coefficients between cumulative radiation dose and cumulative asbestos exposures ranged from 0.09 (occupational dose) to 0.47 (total radiation dose), and those between radiation and welding fume from 0.14 to 0.47. The estimates of relative risk for ionizing radiation and lung cancer were unchanged when lowest and highest estimates of asbestos and welding fumewere considered. These results suggest a fairly large proportion of study population workers were exposed to asbestos and welding fume, that the absolute level of confounding exposure did not affect the risk estimates, and that weak relationships existed between monitored lifetime cumulative occupational radiation dose and asbestos or welding fume. C1 [Zaebst, D. D.; Seel, E. A.; Yiin, J. H.; Nowlin, S. J.; Chen, P.] NIOSH, Cincinnati, OH 45226 USA. RP Zaebst, DD (reprint author), NIOSH, 4676 Columbia Pkwy, Cincinnati, OH 45226 USA. EM ddz1@cdc.gov NR 20 TC 4 Z9 4 U1 1 U2 5 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1545-9624 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2009 VL 6 IS 7 BP 404 EP 414 DI 10.1080/15459620902922573 PG 11 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 447DG UT WOS:000266171200004 PM 19378213 ER PT J AU Lawryk, NJ Feng, HA Chen, BT AF Lawryk, Nicholas J. Feng, H. Amy Chen, Bean T. TI Laboratory Evaluation of a Field-Portable Sealed Source X-Ray Fluorescence Spectrometer for Determination of Metals in Air Filter Samples SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE accuracy; bias; metalworking; precision; welding ID WET CHEMICAL-ANALYSIS; STAINLESS-STEEL; MILD-STEEL; LEAD; CONTAMINATION; PNEUMONITIS; INSTRUMENT; EXPOSURE; WELDERS; SITE AB 5 Recent advances in field-portable X-ray fluorescence (FP XRF) spectrometer technology have made it a potentially valuable screening tool for the industrial hygienist to estimate worker exposures to airborne metals. Although recent studies have shown that FP XRF technology may be better suited for qualitative or semiquantitative analysis of airborne lead in the workplace, these studies have not extensively addressed its ability to measure other elements. This study involved a laboratory-based evaluation of a representative model FP XRF spectrometer to measure elements commonly encountered in workplace settings that may be collected on air sample filter media, including chromium, copper, iron, manganese, nickel, lead, and zinc. The evaluation included assessments of (1) response intensity with respect to location on the probe window, (2) limits of detection for five different filter media, (3) limits of detection as a function of analysis time, and (4) bias, precision, and accuracy estimates. Teflon, polyvinyl chloride, polypropylene, and mixed cellulose ester filter media all had similarly low limits of detection for the set of elements examined. Limits of detection, bias, and precision generally improved with increasing analysis time. Bias, precision, and accuracy estimates generally improved with increasing element concentration. Accuracy estimates met the National Institute for Occupational Safety and Health criterion for nearly all the element and concentration combinations. Based on these results, FP XRF spectrometry shows potential to be useful in the assessment of worker inhalation exposures to other metals in addition to lead. C1 [Lawryk, Nicholas J.] NIOSH, CDC, Hlth Effects Lab Div, Morgantown, WV 26505 USA. [Feng, H. Amy] NIOSH, Commun & Stat Team, Cincinnati, OH 45226 USA. RP Lawryk, NJ (reprint author), NIOSH, CDC, Hlth Effects Lab Div, 1095 Willowdale Rd,M-S G9002, Morgantown, WV 26505 USA. EM NLawryk@cdc.gov NR 49 TC 10 Z9 10 U1 0 U2 7 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1545-9624 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2009 VL 6 IS 7 BP 433 EP 445 DI 10.1080/15459620902932119 PG 13 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 447DG UT WOS:000266171200006 PM 19387888 ER PT J AU Schulte, PA Chun, H AF Schulte, Paul A. Chun, HeeKyoung TI Climate Change and Occupational Safety and Health: Establishing a Preliminary Framework SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Review DE biological hazards; climate change; heat stress; UV radiation; worker health ID PARTICULATE AIR-POLLUTION; WATERBORNE DISEASE OUTBREAKS; UNITED-STATES; ULTRAVIOLET-RADIATION; POTENTIAL IMPACTS; PUBLIC-HEALTH; SKIN-CANCER; US CITIES; EPIDEMIOLOGIC EVIDENCE; HURRICANE-KATRINA AB The relationship between global climate change and occupational safety and health has not been extensively characterized. To begin such an effort, it may be useful to develop a framework for identifying how climate change could affect the workplace; workers; and occupational morbidity, mortality, and injury. This article develops such a framework based on a review of the published scientific literature from 1988-2008 that includes climatic effects, their interaction with occupational hazards, and their manifestation in the working population. Seven categories of climate-related hazards are identified: (1) increased ambient temperature, (2) air pollution, (3) ultraviolet exposure, (4) extreme weather, (5) vector-borne diseases and expanded habitats, (6) industrial transitions and emerging industries; and (7) changes in the built environment. This review indicates that while climate change may result in increasing the prevalence, distribution, and severity of known occupational hazards, there is no evidence of unique or previously unknown hazards. However, such a possibility should not be excluded, since there is potential for interactions of known hazards and new conditions leading to new hazards and risks. C1 [Schulte, Paul A.; Chun, HeeKyoung] NIOSH, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. RP Schulte, PA (reprint author), NIOSH, Ctr Dis Control & Prevent, 4676 Columbia Pkwy,MS C-14, Cincinnati, OH 45226 USA. EM PSchulte@cdc.gov NR 136 TC 41 Z9 41 U1 4 U2 20 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1545-9624 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2009 VL 6 IS 9 BP 542 EP 554 DI 10.1080/15459620903066008 PG 13 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 470KU UT WOS:000267974400005 PM 19551548 ER PT J AU Hall, JC Bernert, JT Hall, DB StHelen, G Kudon, LH Naeher, LP AF Hall, J. C. Bernert, J. T. Hall, D. B. StHelen, G. Kudon, L. H. Naeher, L. P. TI Assessment of Exposure to Secondhand Smoke at Outdoor Bars and Family Restaurants in Athens, Georgia, Using Salivary Cotinine SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE biomarker; outdoors; salivary cotinine; secondhand smoke ID ENVIRONMENTAL TOBACCO-SMOKE; HOSPITALITY WORKERS; FREE LEGISLATION; PASSIVE SMOKING; AIR NICOTINE; IMPLEMENTATION; HEALTH; NONSMOKERS; RISK; BAN AB Exposure to secondhand smoke (SHS) in outdoor settings is a growing public health concern due to recent indoor smoking bans. The objective of this study was to measure salivary cotinine, a metabolite of nicotine, in subjects aged 21-30 exposed to SHS outside bars and restaurants in Athens, Georgia. Nonsmokers participated during 6-hr periods in outdoor standing or seating areas of bars and restaurants where indoor smoking was banned, as well as a control outdoor location with no smokers over six weekends during the summer and early fall of 2007. Pre- and post-exposure saliva samples (N = 25 person-days at the bar site, N = 28 person-days at the restaurant site, and N = 11 person-days at the control) were collected and analyzed for cotinine. The mean change in the response, (ln(post) - ln(pre)) salivary cotinine levels, was significantly impacted by the type of site (bar, restaurant, control) (F = 5.09; d.f. = 2, 6.7; p = 0.0455). The median percent increase in salivary cotinine from pre- test to post-test was estimated to be 162%, 102%, and 16% at the bar, restaurant, and control sites, respectively, values that were significant increases at bars (t = 4.63; d.f. = 9.24; p = 0.0011) and restaurants (t = 4.33; d.f. = 4.47; p = 0.0097) but not at the control sites. On average, these pre- test to post-test increases in salivary cotinine were significantly higher at bar sites than control sites (t = 3.05; d.f. = 9.85; p = 0.0176) and at restaurant sites compared with control sites (t = 2.35; d.f. = 5.09; p = 0.0461). Nonsmokers outside restaurants and bars in Athens, Georgia, have significantly elevated salivary cotinine levels indicative of secondhand smoke exposure. C1 [Hall, J. C.; StHelen, G.; Naeher, L. P.] Univ Georgia, Dept Environm Hlth Sci, Coll Publ Hlth, Athens, GA 30602 USA. [Bernert, J. T.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Hall, D. B.] Univ Georgia, Dept Stat, Athens, GA 30602 USA. [Kudon, L. H.] NE Hlth Dist, Athens, GA USA. RP Naeher, LP (reprint author), Univ Georgia, Dept Environm Hlth Sci, Coll Publ Hlth, EHS Bldg, Athens, GA 30602 USA. EM lnaeher@gmail.com FU Northeast Health District; Athens Community Wellness Council; Athens Tobacco Prevention Coalition FX The authors wish to thank all the participating establishments and study participants. The contributions of Connie Sosnoff, Rick Alexander, and LaQuasha Gaddis to the cotinine analyses are also gratefully acknowledged. This work was funded in part by the Northeast Health District, Athens Community Wellness Council, and the Athens Tobacco Prevention Coalition. NR 31 TC 16 Z9 16 U1 0 U2 5 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1545-9624 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2009 VL 6 IS 11 BP 698 EP 704 DI 10.1080/15459620903249893 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 515XM UT WOS:000271506200008 PM 19757294 ER PT J AU Goldcamp, MJ Goldcamp, DM Ashley, K Fernback, JE Agrawal, A Millson, M Marlow, D Harrison, K AF Goldcamp, Michael J. Goldcamp, Diane M. Ashley, Kevin Fernback, Joseph E. Agrawal, Anoop Millson, Mark Marlow, David Harrison, Kenneth TI Extraction of Beryllium from Refractory Beryllium Oxide with Dilute Ammonium Bifluoride and Determination by Fluorescence: A Multiparameter Performance Evaluation SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article; Proceedings Paper CT 3rd Symposium on Beryllium Particulates and their Detection CY NOV 17-19, 2008 CL Univ New Mexico, Albuquerque, NM HO Univ New Mexico DE beryllium oxide; dissolution; extraction; fluorescence analysis; surface samples ID TRACE BERYLLIUM; ALLOY FACILITY; SENSITIZATION; DISEASE; EXPOSURE; SAMPLES AB Beryllium exposure can cause a number of deleterious health effects, including beryllium sensitization and the potentially fatal chronic beryllium disease. Efficient methods for monitoring beryllium contamination in workplaces are valuable to help prevent dangerous exposures to this element. In this work, performance data on the extraction of beryllium from various size fractions of high-fired beryllium oxide (BeO) particles (from 32 m up to 212 m) using dilute aqueous ammonium bifluoride (ABF) solution were obtained under various conditions. Beryllium concentrations were determined by fluorescence using a hydroxybenzoquinoline fluorophore. The effects of ABF concentration and volume, extraction temperature, sample tube types, and presence of filter or wipe media were examined. Three percent ABF extracts beryllium nearly twice as quickly as 1% ABF; extraction solution volume has minimal influence. Elevated temperatures increase the rate of extraction dramatically compared with room temperature extraction. Sample tubes with constricted tips yield poor extraction rates owing to the inability of the extraction medium to access the undissolved particles. The relative rates of extraction of Be from BeO of varying particle sizes were examined. Beryllium from BeO particles in fractions ranging from less than 32 m up to 212 m were subjected to various extraction schemes. The smallest BeO particles are extracted more quickly than the largest particles, although at 90 degrees C even the largest BeO particles reach nearly quantitative extraction within 4 hr in 3% ABF. Extraction from mixed cellulosic-ester filters, cellulosic surface-sampling filters, wetted cellulosic dust wipes, and cotton gloves yielded 90% or greater recoveries. Scanning electron microscopy of BeO particles, including partially dissolved particles, shows that dissolution in dilute ABF occurs not just on the exterior surface but also via accessing particles' interiors due to porosity of the BeO material. Comparison of dissolution kinetics data shows that as particle diameter approximately doubles, extraction time is increased by a factor of about 1.5, which is consistent with the influence of porosity on dissolution. C1 [Goldcamp, Michael J.; Goldcamp, Diane M.] Wilmington Coll, Wilmington, OH 45177 USA. [Harrison, Kenneth] Brush Ceram, Tucson, AZ USA. [Agrawal, Anoop] Berylliant Inc, Tucson, AZ USA. [Ashley, Kevin; Fernback, Joseph E.; Millson, Mark; Marlow, David] Ctr Dis Control & Prevent, US Dept Hlth & Human Serv, NIOSH, Cincinnati, OH USA. [Goldcamp, Diane M.] Notre Dame Acad, Park Hills, KY USA. RP Goldcamp, MJ (reprint author), Wilmington Coll, 1870 Quaker Way, Wilmington, OH 45177 USA. EM michael_goldcamp@wilmington.edu RI Ashley, Kevin/C-9005-2011 NR 22 TC 6 Z9 6 U1 1 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1545-9624 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2009 VL 6 IS 12 BP 735 EP 744 AR PII 916671055 DI 10.1080/15459620903012044 PG 10 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 517WQ UT WOS:000271650100006 PM 19894174 ER PT J AU Ashley, K Brisson, MJ Howe, AM Bartley, DL AF Ashley, Kevin Brisson, Michael J. Howe, Alan M. Bartley, David L. TI Interlaboratory Evaluation of a Standardized Inductively Coupled Plasma Mass Spectrometry Method for the Determination of Trace Beryllium in Air Filter Samples SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article; Proceedings Paper CT 3rd Symposium on Beryllium Particulates and their Detection CY NOV 17-19, 2008 CL Univ New Mexico, Albuquerque, NM HO Univ New Mexico DE beryllium; consensus standards; inductively coupled plasma-mass spectrometry; interlaboratory analysis; workplace air ID FLUORESCENCE METHOD; EXTRACTION AB A collaborative interlaboratory evaluation of a newly standardized inductively coupled plasma mass spectrometry (ICP-MS) method for determining trace beryllium in workplace air samples was carried out toward fulfillment of method validation requirements for ASTM International voluntary consensus standard test methods. The interlaboratory study (ILS) was performed in accordance with an applicable ASTM International standard practice, ASTM E691, which describes statistical procedures for investigating interlaboratory precision. Uncertainty was also estimated in accordance with ASTM D7440, which applies the International Organization for Standardization Guide to the Expression of Uncertainty in Measurement to air quality measurements. Performance evaluation materials (PEMs) used consisted of 37 mm diameter mixed cellulose ester filters that were spiked with beryllium at levels of 0.025 (low loading), 0.5 (medium loading), and 10 (high loading) g Be/filter; these spiked filters were prepared by a contract laboratory. Participating laboratories were recruited from a pool of over 50 invitees; ultimately, 20 laboratories from Europe, North America, and Asia submitted ILS results. Triplicates of each PEM (blanks plus the three different loading levels) were conveyed to each volunteer laboratory, along with a copy of the draft standard test method that each participant was asked to follow; spiking levels were unknown to the participants. The laboratories were requested to prepare the PEMs by one of three sample preparation procedures (hotplate or microwave digestion or hotblock extraction) that were described in the draft standard. Participants were then asked to analyze aliquots of the prepared samples by ICP-MS and to report their data in units of g Be/filter sample. Interlaboratory precision estimates from participating laboratories, computed in accordance with ASTM E691, were 0.165, 0.108, and 0.151 (relative standard deviation) for the PEMs spiked at 0.025, 0.5, and 10 g Be/filter, respectively. Overall recoveries were 93.2%, 102%, and 80.6% for the low, medium, and high beryllium loadings, respectively. Expanded uncertainty estimates for interlaboratory analysis of low, medium, and high beryllium loadings, calculated in accordance with ASTM D7440, were 18.8%, 19.8%, and 24.4%, respectively. These figures of merit support promulgation of the analytical procedure as an ASTM International standard test method, ASTM D7439. C1 [Ashley, Kevin] Ctr Dis Control & Prevent, US Dept Hlth & Human Serv, NIOSH, Cincinnati, OH USA. [Brisson, Michael J.] Savannah River Nucl Solut, Aiken, SC USA. [Howe, Alan M.] Hlth & Safety Lab, Buxton, Derbyshire, England. [Bartley, David L.] BartlEquations, Cincinnati, OH USA. RP Ashley, K (reprint author), CDC, NIOSH, 4676 Columbia Pkwy,Mail Stop R-7, Cincinnati, OH 45226 USA. EM KAshley@cdc.gov RI Ashley, Kevin/C-9005-2011 NR 26 TC 5 Z9 6 U1 1 U2 6 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1545-9624 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2009 VL 6 IS 12 BP 745 EP 750 AR PII 916670824 DI 10.1080/15459620903022605 PG 6 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 517WQ UT WOS:000271650100007 PM 19894175 ER PT J AU Ekechukwu, A Hendricks, W White, KT Liabastre, A Archuleta, M Hoover, MD AF Ekechukwu, Amy Hendricks, Warren White, Kenneth T. Liabastre, Albert Archuleta, Melecita Hoover, Mark D. TI Validation of Analytical Methods and Instrumentation for Beryllium Measurement: Review and Summary of Available Guides, Procedures, and Protocols SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article; Proceedings Paper CT 3rd Symposium on Beryllium Particulates and their Detection CY NOV 17-19, 2008 CL Univ New Mexico, Albuquerque, NM HO Univ New Mexico DE analytical method development; beryllium; validation; protocol AB This document provides a listing of available sources that can be used to validate analytical methods and/or instrumentation for beryllium determination. A literature review was conducted of available standard methods and publications used for method validation and/or quality control. An annotated listing of the articles, papers, and books reviewed is given in the Appendix. Available validation documents and guides are listed therein; each has a brief description of application and use. In the referenced sources, there are varying approaches to validation and varying descriptions of the validation process at different stages in method development. This discussion focuses on validation and verification of fully developed methods and instrumentation that have been offered for use or approval by other laboratories or official consensus bodies such as ASTM International, the International Standards Organization, the International Electrotechnical Commission, and the Association of Official Analytical Chemists. This review was conducted as part of a collaborative effort to investigate and improve the state of validation for measuring beryllium in the workplace and the environment. Documents and publications from the United States and Europe are included. C1 [Ekechukwu, Amy] Savannah River Natl Lab, Aiken, SC 29808 USA. [Archuleta, Melecita] Sandia Natl Labs, Albuquerque, NM 87185 USA. [Hoover, Mark D.] Ctr Dis Control & Prevent, NIOSH, Morgantown, WV USA. [Hendricks, Warren] Occupat Safety & Hlth Adm, Sandy, UT USA. [White, Kenneth T.] Consult Serv, Virginia Beach, VA USA. [Liabastre, Albert] USA, Ctr Hlth Promot & Prevent Med, Ft Mcpherson, GA USA. RP Ekechukwu, A (reprint author), Savannah River Natl Lab, Analyt Dev Bldg 773-41A, Aiken, SC 29808 USA. EM amy.ekechukwu@srnl.doe.gov RI Hoover, Mark/I-4201-2012 OI Hoover, Mark/0000-0002-8726-8127 NR 0 TC 0 Z9 0 U1 0 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1545-9624 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2009 VL 6 IS 12 BP 766 EP 774 AR PII 916671099 DI 10.1080/15459620903260536 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 517WQ UT WOS:000271650100011 PM 19894179 ER PT J AU Redlich, CA Bello, D Woskie, SR Streicher, RP AF Redlich, Carrie A. Bello, Dhimiter Woskie, Susan R. Streicher, Robert P. TI MEASUREMENTS OF AIRBORNE METHYLENE DIPHENYL DIISOCYANATE CONCENTRATION IN THE US WORKPLACE - COMMENT SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Letter ID OCCUPATIONAL ASTHMA; EXPOSURE; MDI; ISOCYANATES C1 [Redlich, Carrie A.] Yale Univ, Sch Med, Dept Med, Yale Occupat & Environm Med Program, New Haven, CT 06510 USA. [Bello, Dhimiter; Woskie, Susan R.] Univ Massachusetts, Dept Work Environm, Sch Hlth & Environm, Lowell, MA USA. [Streicher, Robert P.] NIOSH, Chem Exposure & Monitoring Branch, Div Appl Res & Technol, Cincinnati, OH 45226 USA. RP Redlich, CA (reprint author), Yale Univ, Sch Med, Dept Med, Yale Occupat & Environm Med Program, New Haven, CT 06510 USA. NR 16 TC 1 Z9 1 U1 1 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1545-9624 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2009 VL 6 IS 11 BP D82 EP D83 DI 10.1080/15459620903256427 PG 2 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 515XM UT WOS:000271506200002 PM 19757291 ER PT J AU Sievers, RE Sievers, EL Searles, JA Cape, SP McAdams, DH Burger, JL Manion, JR Griffin, D Lin, WH Rota, P Papania, M Winston, S Quinn, BP Krank, DM Pathak, P Bhagwat, PA Rebits, LG Evans, S AF Sievers, R. E. Sievers, E. L. Searles, J. A. Cape, S. P. McAdams, D. H. Burger, J. L. Manion, J. R. Griffin, D. Lin, W-H. Rota, P. Papania, M. Winston, S. Quinn, B. P. Krank, D. M. Pathak, P. Bhagwat, P. A. Rebits, L. G. Evans, S. TI Are unit-dose dry powder vaccines intrinsically safer than liquid vaccines? SO JOURNAL OF PHARMACY AND PHARMACOLOGY LA English DT Meeting Abstract C1 [Sievers, R. E.; Searles, J. A.; Cape, S. P.; Quinn, B. P.; Krank, D. M.; Pathak, P.; Bhagwat, P. A.; Rebits, L. G.; Evans, S.] Aktiv Dry LLC, Boulder, CO USA. [Sievers, R. E.; Cape, S. P.; McAdams, D. H.; Burger, J. L.; Manion, J. R.] Univ Colorado, Dept Chem & Biochem, Ctr Pharmaceut Biotechnol, Boulder, CO 80309 USA. [Sievers, R. E.; Cape, S. P.; McAdams, D. H.; Burger, J. L.; Manion, J. R.] Univ Colorado, CIRES, Boulder, CO 80309 USA. [Sievers, E. L.] Seattle Genet, Seattle, WA USA. [Griffin, D.; Lin, W-H.] Johns Hopkins Bloomberg Sch Publ Hlth, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD USA. [Rota, P.; Papania, M.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Winston, S.] Winston Consulting, Boulder, CO USA. EM bobsculpt@aol.com NR 1 TC 0 Z9 0 U1 0 U2 1 PU PHARMACEUTICAL PRESS-ROYAL PHARMACEUTICAL SOC GREAT BRITIAN PI LONDON PA 1 LAMBETH HIGH ST, LONDON SE1 7JN, ENGLAND SN 0022-3573 J9 J PHARM PHARMACOL JI J. Pharm. Pharmacol. PY 2009 VL 61 MA 235 BP A163 EP A163 PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 496ID UT WOS:000269962900236 ER PT J AU Ham, SA Kruger, J Tudor-Locke, C AF Ham, Sandra A. Kruger, Judy Tudor-Locke, Catrine TI Participation by US Adults in Sports, Exercise, and Recreational Physical Activities SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH LA English DT Article DE leisure; walking; time estimation; sports; exercise; recreation ID DIGIT PREFERENCE; DURATION; HEALTH AB Background: Given the evidence that regular physical activity produces substantial health benefits, participation in sports, exercise, and recreation is widely encouraged. The objective of this study was to describe participation in sports, exercise, and recreational physical activities among US adults. Methods: Data from 2 national surveys of respondents age 18 years and older were analyzed. Respondents to the American Time Use Survey (ATUS) from 2003 through 2005 (N = 45,246) reported all activities on 1 randomly selected survey day. Respondents to the National Health and Nutrition Examination Survey (NHANES) from 1999 through 2004 (N = 17,061) reported leisure-time physical activities in the 30 days before the interview. Results: One-quarter of adults participated in any sport, exercise, or recreational activity on a random day, and 60.9% of adults participated in any leisure-time activity in the previous 30 days. The most common types of activities were walking, gardening and yard work, and other forms of exercise. The sports and recreational activities had typical durations of 1/2 to 3 hours per session, and the exercise activities typically lasted 1 hour or less. Conclusions: The prevalence of sports, exercise, and recreational physical activities is generally low among US adults; exercise is the most commonly reported type of activity. C1 [Ham, Sandra A.] Univ Chicago, Sch Divin, Chicago, IL 60637 USA. [Kruger, Judy] Ctr Dis Control & Prevent, Div Nutr Phys Activ & Obes, Atlanta, GA 30341 USA. [Tudor-Locke, Catrine] Pennington Biomed Res Ctr, Walking Behav Lab, Baton Rouge, LA 70808 USA. RP Ham, SA (reprint author), Univ Chicago, Sch Divin, Chicago, IL 60637 USA. NR 27 TC 45 Z9 45 U1 1 U2 16 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1543-3080 J9 J PHYS ACT HEALTH JI J. Phys. Act. Health PD JAN PY 2009 VL 6 IS 1 BP 6 EP 14 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 625XP UT WOS:000279930400002 PM 19211953 ER PT J AU Martin, R AF Martin, Robert TI Examining the Impact of Public Health Assessments SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Editorial Material RP Martin, R (reprint author), Ctr Dis Control & Prevent, Off Global Hlth, Lab Sci, Atlanta, GA 30333 USA. NR 6 TC 2 Z9 2 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD JAN-FEB PY 2009 VL 15 IS 1 BP 1 EP 2 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 384MQ UT WOS:000261749300001 PM 19077587 ER PT J AU Turner, AM Petrochilos, D Nelson, DE Allen, E Liddy, ED AF Turner, Anne M. Petrochilos, Deanna Nelson, David E. Allen, Eileen Liddy, Elizabeth D. TI Access and Use of the Internet for Health Information Seeking: A Survey of Local Public Health Professionals in the Northwest SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE Internet; local health departments AB We conducted an on-line survey of 164 local health departments' staff in five Northwestern states in 2006-2007 to assess Internet access and use by staff. Most (96%) respondents had full-time access to their own worksite computer. The most important selection criterion for selecting Web sites was credibility of the sponsoring organization (55%). Accuracy (46%), reputable source (30%), and currency of information (19%) were considered most critical for assessing information quality. Centers for Disease Control and Prevention (80%) and state health department (60%) sites were used most commonly. These findings can be used to improve public health Web sites and support decision making in practice. C1 [Turner, Anne M.] Univ Washington, Ctr Publ Hlth Informat, Seattle, WA 98195 USA. [Nelson, David E.] Ctr Dis Control & Prevent, Alcohol Team, Atlanta, GA USA. [Allen, Eileen] Syracuse Univ, Sch Informat Studies, Ctr Nat Language Proc, Syracuse, NY USA. RP Turner, AM (reprint author), Univ Washington, Ctr Publ Hlth Informat, Box 354943, Seattle, WA 98195 USA. EM amturner@u.washington.edu FU AHRQ HHS [R01 HS022106]; NLM NIH HHS [1 G08 LM008983-01, T15 LM07442] NR 4 TC 5 Z9 5 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD JAN-FEB PY 2009 VL 15 IS 1 BP 67 EP 69 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 384MQ UT WOS:000261749300011 PM 19077597 ER PT J AU Schier, JG Rubin, CS Miller, D Barr, D McGeehin, MA AF Schier, Joshua G. Rubin, Carol S. Miller, Dorothy Barr, Dana McGeehin, Michael A. TI Medication-associated diethylene glycol mass poisoning: A review and discussion on the origin of contamination SO JOURNAL OF PUBLIC HEALTH POLICY LA English DT Article DE diethylene glycol; mass poisoning; poisoning ID SACCHAROMYCES-CEREVISIAE; GLYCEROL PRODUCTION; FERMENTATION; INTOXICATION; EPIDEMIC; CHILDREN; DEATHS AB Diethylene glycol (DEG), an extremely toxic chemical, has been implicated as the etiologic agent in at least 12 medication-associated mass poisonings over the last 70 years. Why DEG mass poisonings occur remains unclear. Most reports do not contain detailed reports of trace-back investigations into the etiology. The authors, therefore, conducted a systematic literature review on potential etiologies of these mass poisonings. The current available evidence suggests that substitution of DEG or DEG-containing compounds for pharmaceutical ingredients results from: (1) deception as to the true nature of certain ingredients by persons at some point in the pharmaceutical manufacturing process, and (2) failure to adhere to standardized quality control procedures in manufacturing pharmaceutical products intended for consumers. We discuss existing guidelines and new recommendations for prevention of these incidents. Journal of Public Health Policy (2009) 30, 127-143. doi:10.1057/jphp.2009.2 C1 [Schier, Joshua G.; Rubin, Carol S.] Ctr Dis Control & Prevent, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Hlth Studies Branch, Atlanta, GA 30333 USA. [Miller, Dorothy] US FDA, Off Crisis Management, Rockville, MD 20857 USA. [Barr, Dana] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Pesticide Lab, Atlanta, GA USA. RP Schier, JG (reprint author), Ctr Dis Control & Prevent, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Hlth Studies Branch, Atlanta, GA 30333 USA. EM jschier@cdc.gov RI Schier, Joshua/F-9861-2013 NR 47 TC 15 Z9 16 U1 0 U2 6 PU PALGRAVE MACMILLAN LTD PI BASINGSTOKE PA BRUNEL RD BLDG, HOUNDMILLS, BASINGSTOKE RG21 6XS, HANTS, ENGLAND SN 0197-5897 J9 J PUBLIC HEALTH POL JI J. Public Health Policy PY 2009 VL 30 IS 2 BP 127 EP 143 DI 10.1057/jphp.2009.2 PG 17 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA 469OK UT WOS:000267909000001 PM 19597445 ER PT J AU Dodson, EA Fleming, C Boehmer, TK Haire-Joshu, D Luke, DA Brownson, RC AF Dodson, Elizabeth A. Fleming, Chris Boehmer, Tegan K. Haire-Joshu, Debra Luke, Douglas A. Brownson, Ross C. TI Preventing Childhood Obesity through State Policy: Qualitative Assessment of Enablers and Barriers SO JOURNAL OF PUBLIC HEALTH POLICY LA English DT Article DE children; legislators; obesity; policy ID HEALTH-POLICY; LESSONS; PREVALENCE; LAW AB As the prevalence of obesity rapidly climbs among youth in the United States, public health practitioners and policymakers seek effective means of slowing and reversing these trends. Recently, many state laws and regulations addressing childhood obesity have been introduced and enacted. Understanding determinants of such legislation may inform the development and passage of future policies. For this study, key-informant interviews were conducted with 16 legislators and staffers from 11 states in 2005-2006 to examine qualitative factors that enable and impede state-level childhood obesity prevention legislation. Commonly cited factors positively influencing the passage of childhood obesity prevention legislation included national media exposure, introduction of the policy by senior legislators, and gaining the support of key players including parents, physicians, and schools. Noteworthy barriers included powerful lobbyists of companies that produce unhealthy foods and misconceptions about legislating foods at schools. Although the total number of informants was modest, their valuable insights provide policymakers and practitioners with a set of enablers and barriers to be considered when pursuing state-level policy. C1 [Dodson, Elizabeth A.] Washington Univ, George Warren Brown Sch Social Work, Prevent Res Ctr St Louis, St Louis, MO 63110 USA. [Dodson, Elizabeth A.; Fleming, Chris; Boehmer, Tegan K.; Haire-Joshu, Debra; Luke, Douglas A.; Brownson, Ross C.] St Louis Univ, Sch Publ Hlth, St Louis, MO 63103 USA. [Fleming, Chris] Math Policy Res Inc, Washington, DC USA. [Boehmer, Tegan K.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. [Haire-Joshu, Debra] Washington Univ, George Warren Brown Sch Social Work, Ctr Obes Prevent & Policy Res, St Louis, MO 63110 USA. [Haire-Joshu, Debra] Washington Univ, Sch Med, St Louis, MO 63110 USA. [Luke, Douglas A.] Washington Univ, George Warren Brown Sch Social Work, Ctr Tobacco Policy Res, St Louis, MO 63110 USA. [Brownson, Ross C.] Washington Univ, Sch Med, Siteman Canc Ctr, Dept Surg, St Louis, MO 63110 USA. RP Dodson, EA (reprint author), Washington Univ, George Warren Brown Sch Social Work, Prevent Res Ctr St Louis, 660 S Euclid Ave,Campus Box 8109, St Louis, MO 63110 USA. EM edodson@wustl.edu; cflem17@yahoo.com; tboehmer@cdc.gov; djoshu@wustl.edu; dluke@wustl.edu; rbrownson@wustl.edu OI Luke, Douglas/0000-0003-1332-8569 FU Robert Wood Johnson Foundation [053630]; Centers for Disease Control and Prevention [U48/DP000060] FX We are grateful for the contributions of Mariah Dreisinger and Hannalori Bates from St. Louis University School of Public Health and Dr. Tracy Orleans from the Robert Wood Johnson Foundation. Funding for this project was provided by the Robert Wood Johnson Foundation ( Grant #053630) and the Centers for Disease Control and Prevention contract U48/DP000060 ( Prevention Research Centers Program). Research was conducted at St. Louis University School of Public Health, St. Louis, Missouri, United States. NR 28 TC 35 Z9 35 U1 2 U2 6 PU PALGRAVE MACMILLAN LTD PI BASINGSTOKE PA BRUNEL RD BLDG, HOUNDMILLS, BASINGSTOKE RG21 6XS, HANTS, ENGLAND SN 0197-5897 J9 J PUBLIC HEALTH POL JI J. Public Health Policy PY 2009 VL 30 BP S161 EP S176 DI 10.1057/jphp.2008.57 PG 16 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA 405QQ UT WOS:000263239700012 PM 19190572 ER PT J AU Borse, NN Gilchrist, J Dellinger, AM Rudd, RA Ballesteros, MF Sleet, DA AF Borse, Nagesh N. Gilchrist, Julie Dellinger, Ann M. Rudd, Rose A. Ballesteros, Michael F. Sleet, David A. TI Unintentional childhood injuries in the United States: Key findings from the CDC childhood injury report SO JOURNAL OF SAFETY RESEARCH LA English DT Article C1 [Borse, Nagesh N.; Gilchrist, Julie; Dellinger, Ann M.; Rudd, Rose A.; Ballesteros, Michael F.; Sleet, David A.] Ctr Dis Control & Prevent, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA. RP Borse, NN (reprint author), Ctr Dis Control & Prevent, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, 4770 Buford Highway NE,MS F-62, Atlanta, GA 30341 USA. EM nborse@cdc.gov RI Borse, Nagesh/A-9276-2009 NR 4 TC 12 Z9 14 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4375 J9 J SAFETY RES JI J. Saf. Res. PY 2009 VL 40 IS 1 BP 71 EP 74 DI 10.1016/j.jsr.2009.01.002 PG 4 WC Ergonomics; Public, Environmental & Occupational Health; Social Sciences, Interdisciplinary; Transportation SC Engineering; Public, Environmental & Occupational Health; Social Sciences - Other Topics; Transportation GA 429FA UT WOS:000264905100011 PM 19285589 ER PT J AU Shults, RA Elder, RW Hungerford, DW Strife, BJ Ryan, GW AF Shults, Ruth A. Elder, Randy W. Hungerford, Daniel W. Strife, Brian J. Ryan, George W. TI Emergency department visits for alcohol-related unintentional traumatic injuries, United States, 2001 SO JOURNAL OF SAFETY RESEARCH LA English DT Article ID BRIEF INTERVENTION; FEASIBILITY C1 [Shults, Ruth A.] Ctr Dis Control & Prevent, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA. [Elder, Randy W.; Strife, Brian J.] Virginia Commonwealth Univ, Sch Med, Richmond, VA 23298 USA. RP Shults, RA (reprint author), Ctr Dis Control & Prevent, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, 4770 Buford Highway NE,Mailstop F-62, Atlanta, GA 30341 USA. EM rshults@cdc.gov NR 14 TC 6 Z9 6 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4375 J9 J SAFETY RES JI J. Saf. Res. PY 2009 VL 40 IS 4 BP 329 EP 331 DI 10.1016/j.jsr.2009.06.001 PG 3 WC Ergonomics; Public, Environmental & Occupational Health; Social Sciences, Interdisciplinary; Transportation SC Engineering; Public, Environmental & Occupational Health; Social Sciences - Other Topics; Transportation GA 513VS UT WOS:000271352800011 PM 19778657 ER PT J AU Beck, LF Shults, RA AF Beck, Laurie F. Shults, Ruth A. TI Seat Belt Use in States and Territories with Primary and Secondary Laws - United States, 2006 SO JOURNAL OF SAFETY RESEARCH LA English DT Article DE Seat belt; Injury; Motor vehicle crash; Motor vehicle; Surveillance ID ENFORCEMENT AB Problem: Motor-vehicle crashes are a leading cause of death in the United States. In the event of a crash, seat belts are highly effective in preventing serious injury and death. Methods: Data from the 2006 Behavioral Risk Factor Surveillance System were used to calculate prevalence of seat belt use by state and territory and by type of state seat belt law (primary vs. secondary enforcement). Results: In 2006, seat belt use among adults ranged from 58.3% to 91.9% in the states and territories. Seat belt use was 86.0% in states and territories with primary enforcement laws and 75.9% in states with secondary enforcement laws. Discussion: Seat belt use continues to increase in the United States. Primary enforcement laws remain a more effective strategy than secondary enforcement laws in getting motor-vehicle occupants to wear their seat belts. National Safety Council and Elsevier Ltd. All rights reserved. C1 [Beck, Laurie F.; Shults, Ruth A.] Natl Ctr Injury Prevent & Control, Div Unintent Injury Prevent, Atlanta, GA 30341 USA. RP Beck, LF (reprint author), Natl Ctr Injury Prevent & Control, Div Unintent Injury Prevent, 4770 Buford Highway NE,MS F-62, Atlanta, GA 30341 USA. EM LBeck@cdc.gov NR 12 TC 18 Z9 20 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4375 J9 J SAFETY RES JI J. Saf. Res. PY 2009 VL 40 IS 6 BP 469 EP 472 DI 10.1016/j.jsr.2009.09.004 PG 4 WC Ergonomics; Public, Environmental & Occupational Health; Social Sciences, Interdisciplinary; Transportation SC Engineering; Public, Environmental & Occupational Health; Social Sciences - Other Topics; Transportation GA 534LT UT WOS:000272899300010 PM 19945561 ER PT J AU Gray, SK Griffin, SO Malvitz, DM Gooch, BF AF Gray, Shellie Kolavic Griffin, Susan O. Malvitz, Dolores M. Gooch, Barbara F. TI A Comparison of the effects of toothbrushing and handpiece prophylaxis on retention of sealants SO JOURNAL OF THE AMERICAN DENTAL ASSOCIATION LA English DT Review DE Dental sealants; pit-and-fissure sealants; acid etching; dental prophylaxis; toothbrush cleaning; dental cleaning ID GLASS-IONOMER CEMENT; RESIN-BASED PIT; FISSURE SEALANT; CLINICAL-EVALUATION; CARIES PREVENTION; OCCLUSAL CARIES; ENAMEL SURFACES; PERMANENT TEETH; DENTAL-CARIES; FLUORIDE AB Background. Tooth surface cleaning before acid etching is considered to be an important step in the retention of resin-based pit-and-fissure sealants. Methods. The authors reviewed and summarized instructions for cleaning tooth surfaces from five manufacturers of 10 unfilled resin-based sealants marketed in the United States. The authors also searched electronic databases for studies that directly compared the effects of different surface-cleaning methods on sealant retention and for systematic reviews of the effectiveness of sealants. They explored the association between surface-cleaning methods and sealant retention in the studies included in the systematic reviews. They calculated the summary weighted retention rates for studies that used either a handpiece or toothbrush prophylaxis. Results. All of the sealant manufacturers' instructions for use (IFU) recommended cleaning the tooth before acid etching. None of the IFU directly stated that a handpiece was required to perform the cleaning, but five IFU implied the use of handpiece prophylaxis. None of the IFU recommended surface-altering procedures in caries-free teeth. Direct evidence from two clinical trials showed no difference in complete sealant retention between surfaces cleaned mechanically with pumice or prophylaxis paste and those cleaned with air-water syringe or dry toothbrushing. Indirect evidence from 10 studies found that weighted summary retention by year after sealant placement in studies that used toothbrush prophylaxis was greater than or equivalent to values for studies that used handpiece prophylaxis. Conclusions. Levels of sealant retention after surface cleaning with toothbrush prophylaxis were at least as high as those associated with handpiece prophylaxis. Clinical Implications. This finding may translate into lower resource costs for sealant placement. C1 [Griffin, Susan O.; Gooch, Barbara F.] Ctr Dis Control & Prevent, Surveillance Invest & Res Branch, Div Oral Hlth, Chamblee, GA 30341 USA. [Gray, Shellie Kolavic] Northrop Grumman, Publ Hlth Div, Atlanta, GA USA. [Malvitz, Dolores M.] Palladian Partners, Silver Spring, MD USA. RP Gooch, BF (reprint author), Ctr Dis Control & Prevent, Surveillance Invest & Res Branch, Div Oral Hlth, 4770 Buford Highway,Mailstop F10, Chamblee, GA 30341 USA. EM bfg1@cdc.gov NR 88 TC 12 Z9 14 U1 0 U2 3 PU AMER DENTAL ASSOC PI CHICAGO PA 211 E CHICAGO AVE, CHICAGO, IL 60611 USA SN 0002-8177 J9 J AM DENT ASSOC JI J. Am. Dent. Assoc. PD JAN PY 2009 VL 140 IS 1 BP 38 EP 46 PG 9 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 392SV UT WOS:000262323400012 ER PT J AU Tessema, J Jefferds, ME Cogswell, M Carlton, E AF Tessema, Judith Jefferds, Maria Elena Cogswell, Mary Carlton, Ewa TI Motivators and Barriers to Prenatal Supplement Use among Minority Women in the United States SO JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION LA English DT Article ID IRON-DEFICIENCY; ADHERENCE; CARE; WEIGHT; ANEMIA; BIRTH AB Minority women in the United States are at a higher risk of iron deficiency and less likely to report use of prenatal supplements compared with non-Hispanic white women. Little information exists on the perceived benefits and barriers to prenatal supplement use. We analyzed the results of 12 focus groups conducted with African-American and Hispanic women (n=104). Groups were equally divided into consistent (five to seven times per week for 3 or more months) and inconsistent (zero to four times per week for 0 to 2 months) users and by race/ethnicity. We examined motivators and barriers to prenatal supplement use and identified common themes; we also compared responses between consistent and inconsistent users, and between African American and Hispanic women. For all groups, positive effects, convenient supply, affordability, and reinforcement by health care providers enhanced adherence. Common barriers were prenatal supplement qualities, adverse effects, and poor communication from health care providers about the benefits of use. Common motivators among consistent users included social network reinforcement of daily intake and fear of adverse effects to the fetus if prenatal supplements were not taken. Common barriers among inconsistent users included skepticism toward the efficacy and necessity of prenatal supplements and the health care provider assenting to nonadherence. Prenatal supplement use was influenced by multiple factors in women's daily lives. Adherence will likely be enhanced by reducing barriers related to prenatal supplement qualities and adverse effects, improving social network support, and improving health care provider interactions. C1 [Tessema, Judith; Jefferds, Maria Elena] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA 30341 USA. [Cogswell, Mary] Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Atlanta, GA 30341 USA. [Carlton, Ewa] Macro Int, Div Appl Human Technol, Calverton, MD USA. RP Tessema, J (reprint author), Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, 4770 Buford Hwy NE,MS,K-25, Atlanta, GA 30341 USA. EM jtessem@sph.emory.edu NR 22 TC 11 Z9 11 U1 1 U2 9 PU AMER DIETETIC ASSOC PI CHICAGO PA 216 W JACKSON BLVD #800, CHICAGO, IL 60606-6995 USA SN 0002-8223 J9 J AM DIET ASSOC JI J. Am. Diet. Assoc. PD JAN PY 2009 VL 109 IS 1 BP 102 EP 108 DI 10.1016/j.jada.2008.10.013 PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 394ZY UT WOS:000262492900018 PM 19103329 ER PT J AU Reti, SR Feldman, HJ Safran, C AF Reti, Shane R. Feldman, Henry J. Safran, Charles TI Governance for Personal Health Records SO JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION LA English DT Article; Proceedings Paper CT Spring Congress of the American-Medical-Informatics-Association CT AMIA Annual Spring Conference 2008 CY MAY 29-31, 2008 CY MAY 29-31, 2008 CL Phoenix, AZ CL Phoenix, AZ SP Amer Med Informat Assoc SP AMIA ID MEDICAL-RECORDS; EXPERIENCE; ACCESS AB Personal health records (PHR) are a modern health technology with the ability to engage patients more fully in their healthcare. Despite widespread interest, there has been little discussion around PHR governance at an organizational level. We develop a governance model and compare it to the practices of some of the early PHR adopters, including hospitals and ambulatory care settings, insurers and health plans, government departments, and commercial sectors. Decision-making structures varied between organizations. Business operations were present in all groups, but patients were not represented in any of the governance structures surveyed. To improve patient-centered care, policy making for PHRs needs to include patient representation at a governance level. C1 [Reti, Shane R.; Feldman, Henry J.; Safran, Charles] Beth Israel Deaconess Med Ctr, Div Clin Informat, Dept Med, Boston, MA 02215 USA. [Reti, Shane R.] Univ Auckland, Dept Gen Practice & Primary Hlth Care, Auckland 1, New Zealand. [Safran, Charles] Ctr Dis Control & Prevent, Natl Ctr Publ Hlth Informat, Atlanta, GA USA. RP Reti, SR (reprint author), Beth Israel Deaconess Med Ctr, Div Clin Informat, 1330 Beacon St,Suite 400, Brookline, MA 02446 USA. EM sreti@bidmc.harvard.edu NR 23 TC 20 Z9 21 U1 1 U2 10 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1067-5027 EI 1527-974X J9 J AM MED INFORM ASSN JI J. Am. Med. Inf. Assoc. PD JAN-FEB PY 2009 VL 16 IS 1 BP 14 EP 17 DI 10.1197/jamia.M2854 PG 4 WC Computer Science, Information Systems; Computer Science, Interdisciplinary Applications; Health Care Sciences & Services; Information Science & Library Science; Medical Informatics SC Computer Science; Health Care Sciences & Services; Information Science & Library Science; Medical Informatics GA 396UB UT WOS:000262615600003 PM 18952939 ER PT J AU Lazarus, R Klompas, M Campion, FX McNabb, SJN Hou, XL Daniel, J Haney, G DeMaria, A Lenert, L Platt, R AF Lazarus, Ross Klompas, Michael Campion, Francis X. McNabb, Scott J. N. Hou, Xuanlin Daniel, James Haney, Gillian DeMaria, Alfred Lenert, Leslie Platt, Richard TI Electronic Support for Public Health: Validated Case Finding and Reporting for Notifiable Diseases Using Electronic Medical Data SO JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION LA English DT Article ID INFECTIOUS-DISEASES; SYSTEM; SURVEILLANCE; TIMELINESS; LABORATORIES; RECORDS AB Health care providers are legally obliged to report cases of specified diseases to public health authorities but existing manual, provider-initiated reporting systems generally result in incomplete, error-prone, and tardy information flow. Automated laboratory-based reports are more likely accurate and timely, but lack clinical information and treatment details. Here, we describe the Electronic Support for Public Health (ESP) application, a robust, automated, secure, portable public health detection and messaging system for cases of notifiable diseases. The ESP application applies disease specific logic to any complete source of electronic medical data in a fully automated process, and supports an optional case management workflow system for case notification control. All relevant clinical, laboratory and demographic details are securely transferred to the local health authority as an HL7 message. The ESP application has operated continuously in production mode since January 2007, applying rigorously validated case identification logic to ambulatory EMR data from more than 600,000 patients. Source code for this highly interoperable application is freely available under an approved open-source license at http://esphealth.org. C1 [Lazarus, Ross; Klompas, Michael; Hou, Xuanlin; Platt, Richard] Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA. [Lazarus, Ross; Klompas, Michael; Hou, Xuanlin; Platt, Richard] Harvard Univ, Sch Med, Dept Ambulatory Care & Prevent, Boston, MA USA. [Lazarus, Ross; Klompas, Michael; Hou, Xuanlin; Platt, Richard] Harvard Pilgrim Hlth Care, Boston, MA USA. [Campion, Francis X.] Atrius Hlth, Boston, MA USA. [McNabb, Scott J. N.; Lenert, Leslie] Ctr Dis Control & Prevent, Natl Ctr Publ Hlth Informat, Atlanta, GA USA. [Daniel, James; Haney, Gillian; DeMaria, Alfred] Massachusetts Dept Publ Hlth, Boston, MA USA. RP Lazarus, R (reprint author), Brigham & Womens Hosp, Channing Lab, 181 Longwood Ave, Boston, MA 02115 USA. EM ross.lazarus@gmail.com OI lazarus, ross/0000-0003-3939-1961 FU Centers for Disease Control [PH000238D]; Agency for Healthcare Research and Quality [HS 17045] FX Supported by grants from the Centers for Disease Control (PH000238D) and from the Agency for Healthcare Research and Quality (HS 17045). NR 22 TC 41 Z9 42 U1 0 U2 7 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1067-5027 J9 J AM MED INFORM ASSN JI J. Am. Med. Inf. Assoc. PD JAN-FEB PY 2009 VL 16 IS 1 BP 18 EP 24 DI 10.1197/jamia.M2848 PG 7 WC Computer Science, Information Systems; Computer Science, Interdisciplinary Applications; Information Science & Library Science; Medical Informatics SC Computer Science; Information Science & Library Science; Medical Informatics GA 396UB UT WOS:000262615600004 PM 18952940 ER PT J AU Taffa, N Will, JC Bodika, S Packel, L Motlapele, D Stein, E Roels, TH Kennedy, G Shenaaz, EH AF Taffa, Negussie Will, Julie C. Bodika, Stephane Packel, Laura Motlapele, Diemo Stein, Ellen Roels, Thierry H. Kennedy, Gail Shenaaz, El-Halabi TI Validation of AIDS-related mortality in Botswana SO JOURNAL OF THE INTERNATIONAL AIDS SOCIETY LA English DT Article AB Background: Mortality data are used to conduct disease surveillance, describe health status and inform planning processes for health service provision and resource allocation. In many countries, HIV- and AIDS-related deaths are believed to be under-reported in government statistics. Methods: To estimate the extent of under-reporting of HIV- and AIDS-related deaths in Botswana, we conducted a retrospective study of a sample of deaths reported in the government vital registration database from eight hospitals, where more than 40% of deaths in the country in 2005 occurred. We used the consensus of three physicians conducting independent reviews of medical records as the gold standard comparison. We examined the sensitivity, specificity and other validity statistics. Results: Of the 5276 deaths registered in the eight hospitals, 29% were HIV- and AIDS-related. The percentage of HIV-and AIDS-related deaths confirmed by physician consensus (positive predictive value) was 95.4%; however, the percentage of non-HIV- and non-AIDS-related deaths confirmed (negative predictive value) was only 69.1%. The sensitivity and specificity of the vital registration system was 55.7% and 97.3%, respectively. After correcting for misclassification, the percentage of HIV- and AIDS--related deaths was estimated to be in the range of 48.8% to 54.4%, depending on the definition. Conclusion: Improvements in hospitals and within government offices are necessary to strengthen the vital registration system. These should include such strategies as training physicians and coders in accurate reporting and recording of death statistics, implementing continuous quality assurance methods, and working with the government to underscore the importance of using mortality statistics in future evidence-based planning. C1 [Taffa, Negussie; Bodika, Stephane; Roels, Thierry H.] Ctr Dis Control & Prevent, BOTUSA Botswana USA, Gaborone, Botswana. [Will, Julie C.] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA USA. [Packel, Laura; Stein, Ellen; Kennedy, Gail] Univ Calif San Francisco, Dept Epidemiol, San Francisco, CA 94143 USA. [Packel, Laura; Stein, Ellen; Kennedy, Gail] Univ Calif San Francisco, Inst Global Hlth, San Francisco, CA 94143 USA. [Motlapele, Diemo] Minist Hlth, Dept Policy Planning Monitoring & Evaluat, Gaborone, Botswana. [Shenaaz, El-Halabi] Minist Hlth, Dept Primary Hlth Care, Gaborone, Botswana. RP Taffa, N (reprint author), Ctr Dis Control & Prevent, BOTUSA Botswana USA, Gaborone, Botswana. EM TaffaN@bw.cdc.gov; JXW6@cdc.gov; BodikaS@bw.cdc.gov; LPackel@psg.ucsf.edu; Dmotlapele@gov.bw; EStein@psg.ucsf.edu; RoelsT@bw.cdc.gov; GKennedy@psg.ucsf.edu; sel-halabi@gov.bw NR 16 TC 2 Z9 2 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1758-2652 J9 J INT AIDS SOC JI J. Int. AIDS Soc. PY 2009 VL 12 AR 24 DI 10.1186/1758-2652-12-24 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA V19YA UT WOS:000208106500024 PM 19852854 ER PT J AU Harris, CA Fisher, JW Rollor, EA Ferguson, DC Blount, BC Valentin-Blasini, L Taylor, MA Dallas, CE AF Harris, C. A. Fisher, J. W. Rollor, E. A., III Ferguson, D. C. Blount, B. C. Valentin-Blasini, L. Taylor, M. A. Dallas, C. E. TI Evaluation of Potassium Iodide (KI) and Ammonium Perchlorate (NH4ClO4) to Ameliorate 131I-Exposure in the Rat SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES LA English DT Article ID THYROID IRRADIATION; CHERNOBYL ACCIDENT; STABLE IODINE; I-131; PROPHYLAXIS; BLOCKING; CANCER; GLAND AB Nuclear reactor accidents and the threat of nuclear terrorism have heightened the concern for adverse health risks associated with radiation poisoning. Potassium iodide (KI) is the only pharmaceutical intervention that is currently approved by the Food and Drug Administration for treating 131I- exposure, a common radioactive fission product. Though effective, KI administration needs to occur prior to or as soon as possible (within a few hours) after radioactive exposure to maximize the radioprotective benefits of KI. During the Chernobyl nuclear reactor accident, KI was not administered soon enough after radiation poisoning occurred to thousands of people. The delay in administration of KI resulted in an increased incidence of childhood thyroid cancer. Perchlorate (ClO4-) was suggested as another pharmaceutical radioprotectant for 131I- poisoning because of its ability to block thyroidal uptake of iodide and discharge free iodide from the thyroid gland. The objective of this study was to compare the ability of KI and ammonium perchlorate to reduce thyroid gland exposure to radioactive iodide (131I-). Rats were dosed with 131I- tracer and 0.5 and 3 h later dosed orally with 30 mg/kg of either ammonium perchlorate or KI. Compared to controls, both anion treatments reduced thyroid gland exposure to 131I- equally, with a reduction ranging from 65 to 77%. Ammonium perchlorate was more effective than stable iodide for whole-body radioprotectant effectiveness. KI-treated animals excreted only 30% of the 131I- in urine after 15 h, compared to 47% in ammonium perchlorate-treated rats. Taken together, data suggest that KI and ammonium perchlorate are both able to reduce thyroid gland exposure to 131I- up to 3 h after exposure to 131I-. Ammonium perchlorate may offer an advantage over KI because of its ability to clear 131I- from the body. C1 [Harris, C. A.] Univ Georgia, Inst Hlth Management & Mass Destruct Def, Interdisciplinary Toxicol Program, Athens, GA 30602 USA. [Blount, B. C.; Valentin-Blasini, L.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Harris, CA (reprint author), Univ Georgia, Inst Hlth Management & Mass Destruct Def, Interdisciplinary Toxicol Program, Barrow Hall 001, Athens, GA 30602 USA. EM charris@ihmd.uga.edu NR 26 TC 1 Z9 1 U1 0 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1528-7394 EI 1087-2620 J9 J TOXICOL ENV HEAL A JI J. Toxicol. Env. Health Part A PY 2009 VL 72 IS 14 BP 909 EP 914 AR PII 912659121 DI 10.1080/15287390902959672 PG 6 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 462QU UT WOS:000267371500007 PM 19557619 ER PT J AU Habash, RWY Elwood, JM Krewski, D Lotz, WG McNamee, JP Prato, FS AF Habash, Riadh W. Y. Elwood, J. Mark Krewski, Daniel Lotz, W. Gregory McNamee, James P. Prato, Frank S. TI RECENT ADVANCES IN RESEARCH ON RADIOFREQUENCY FIELDS AND HEALTH: 2004-2007 SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS LA English DT Review ID MOBILE PHONE USE; RAT-BRAIN CELLS; IN-VITRO EXPOSURE; MHZ ELECTROMAGNETIC-FIELDS; GSM-MODULATED RADIOFREQUENCY; CENTRAL-NERVOUS-SYSTEM; HEART-RATE-VARIABILITY; INTERPHONE-STUDY-GROUP; DNA STRAND BREAKS; WIRELESS COMMUNICATION SIGNALS AB The widespread use of wireless telecommunications devices, particularly mobile phones and wireless networks, has resulted in increased human exposure to radiofrequency (RF) fields. Although national and international agencies have established safety guidelines for exposure to RF fields, concerns remain about the potential for adverse health outcomes to occur in relation to RF field exposure. The extensive literature on RF fields and health was reviewed by a number of authorities, including the Royal Society of Canada (1999). This report is the third in a series of updates to the original report of the Royal Society of Canada, covering the period 2004-2007. In particular, the present study examined new data on (1) dosimetry and exposure assessment, (2) biological effects of RF fields such as enzyme induction, and (3) toxicological effects, including genotoxicity and carcinogenicity. Epidemiological studies of the potential health effects of RF exposure, particularly from mobile phones, were determined, along with human and animal studies of neurological and behavioural effects. Within the last 4 yrs investigators concluded that there is no clear evidence of adverse health effects associated with RF fields, although continued research is recommended to address specific areas of concern, including exposure to RF fields among children using mobile phones. The results of the ongoing 13-country World Health Organization INTERPHONE study of mobile phones may provide important new information on the potential cancer risks associated with mobile phone use. C1 [Habash, Riadh W. Y.; Krewski, Daniel] Univ Ottawa, R Samuel McLaughlin Ctr Populat Hlth Risk Assessm, Ottawa, ON K1N 6N5, Canada. [Habash, Riadh W. Y.] Univ Ottawa, Sch Informat Technol & Engn, Ottawa, ON K1N 6N5, Canada. [Elwood, J. Mark] British Columbia Canc Agcy, Vancouver, BC V5Z 4E6, Canada. [Lotz, W. Gregory] NIOSH, Div Biomed & Behav Sci, Cincinnati, OH 45226 USA. [McNamee, James P.] Hlth Canada, Consumer & Clin Radiat Protect Bur, Ottawa, ON K1A 0L2, Canada. [Prato, Frank S.] Univ Western Ontario, Dept Diagnost Radiol & Nucl Med, London, ON, Canada. [Prato, Frank S.] Univ Western Ontario, Lawson Hlth Res Inst, London, ON, Canada. RP Habash, RWY (reprint author), Univ Ottawa, R Samuel McLaughlin Ctr Populat Hlth Risk Assessm, 1 Stewart St,Room 320, Ottawa, ON K1N 6N5, Canada. EM rhabash@site.uottawa.ca RI Prato, Frank/C-9117-2014; OI McNamee, James/0000-0003-2772-3455 NR 265 TC 18 Z9 21 U1 3 U2 17 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1093-7404 EI 1521-6950 J9 J TOXICOL ENV HEAL B JI J. Toxicol. Env. Health-Pt b-Crit. Rev. PY 2009 VL 12 IS 4 BP 250 EP 288 DI 10.1080/10937400903094125 PG 39 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 483GV UT WOS:000268952000002 PM 20183523 ER PT J AU Orloff, K Mistry, K Metcalf, S AF Orloff, Kenneth Mistry, Ketna Metcalf, Susan TI BIOMONITORING FOR ENVIRONMENTAL EXPOSURES TO ARSENIC SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS LA English DT Review ID PLASMA-MASS SPECTROMETRY; PERIPHERAL-BLOOD LYMPHOCYTES; NEUTRON-ACTIVATION ANALYSIS; DRINKING-WATER; SMELTER WORKERS; WEST-BENGAL; HAIR ANALYSIS; WELL WATER; BLACKFOOT-DISEASE; URINARY-EXCRETION AB Arsenic (As) is a widely occurring environmental contaminant. To assess human exposures to As, public health officials and researchers often conduct biomonitoring. Samples of urine, hair, nails, or blood are collected from potentially exposed people and are analyzed for As compounds and their metabolites. When analyzing for As exposure, it is useful to distinguish between As species, since they differ in their origin and toxicity. Urine is the most frequently used biological medium for biomonitoring. Measuring the urinary concentration of As is useful in assessing recent exposure to As, and high-quality reference ranges are available for urinary As concentrations in the U. S. population. Biomonitoring for As in hair and nails has been used in many studies and is particularly useful in evaluating chronic exposures to As. Interpreting the health implications of As concentrations in biological samples is limited by the small number of studies that provide information on the correlation and dose-response relationship between biomonitoring test results and adverse health effects. This study discusses the advantages and limitations of biomonitoring for As in biological samples and provides illustrative case studies. C1 [Orloff, Kenneth; Mistry, Ketna; Metcalf, Susan] Agcy Toxic Subst & Dis Registry, Div Hlth Assessment & Consultat, Atlanta, GA 30341 USA. RP Orloff, K (reprint author), Agcy Toxic Subst & Dis Registry, Div Hlth Assessment & Consultat, Mail Stop F-59,4770 Buford Highway NE, Atlanta, GA 30341 USA. EM keo1@cdc.gov NR 97 TC 55 Z9 58 U1 2 U2 18 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1093-7404 J9 J TOXICOL ENV HEAL B JI J. Toxicol. Env. Health-Pt b-Crit. Rev. PY 2009 VL 12 IS 7 BP 509 EP 524 DI 10.1080/10937400903358934 PG 16 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 540KU UT WOS:000273331200001 PM 20183531 ER PT J AU Hennessey, KA Kim, AA Griffin, V Collins, NT Weinbaum, CM Sabin, K AF Hennessey, Karen A. Kim, Andrea A. Griffin, Vivian Collins, Nicoline T. Weinbaum, Cindy M. Sabin, Keith TI Prevalence of Infection with Hepatitis B and C Viruses and Co-infection with HIV in Three Jails: A Case for Viral Hepatitis Prevention in Jails in the United States SO JOURNAL OF URBAN HEALTH-BULLETIN OF THE NEW YORK ACADEMY OF MEDICINE LA English DT Article DE Viral hepatitis; Co-infections; Correctional facilities ID CORRECTIONAL FACILITIES; INMATES; CALIFORNIA; PRISONS; SYSTEM; SEROEPIDEMIOLOGY; TRANSMISSION; VACCINATION AB Hepatitis B vaccination and targeted testing for hepatitis C virus (HCV) are recommended for jails with medical services available. This study estimates hepatitis B virus (HBV) and HCV infection prevalence among jail inmates, since most previous studies have been conducted among prison inmates. Prison and jail populations differ: jails hold a wide spectrum of persons for an average of 10-20 days, including persons awaiting arraignment, trial, conviction, or sentencing, while prisons typically hold convicted criminals for at least 1 year. A stratified random sample of sera obtained during routine syphilis testing of inmates entering jails in Chicago (March-April 2000), Detroit (March-August 1999), and San Francisco (June 1999-December 2000) was tested for serologic markers of HBV and HCV infection. All sera had been previously tested for antibody to HIV (anti-HIV). A total of 1,292 serum samples (12% of new inmates) was tested. Antibody to HCV (anti-HCV) prevalence was 13%. Antibody to hepatitis B core antigen (anti-HBc) prevalence was 19%, and hepatitis B surface antigen (HBsAg) prevalence was 0.9%; 12% had serologic evidence of hepatitis B vaccination. Hispanics had high rates of chronic HBV infection (3.6% HBsAg positive) along with Asians (4.7% HBsAg positive). Among HIV-infected persons, 38% were anti-HCV positive and 8.2% were HBsAg positive. Anti-HBc positivity was associated with anti-HCV positivity (aOR = 4.58), anti-HIV positivity (aOR = 2.94), syphilis infection (aOR = 2.10), and previous incarceration (aOR = 1.78). Anti-HCV-positivity was associated with anti-HBc positivity (aOR = 4.44), anti-HIV-positivity (aOR = 2.51), and previous incarceration (aOR = 2.90). Jail entrants had high levels of HCV and HBV infection and HIV co-infection; HBV prevalence was comparable to previous prison studies, and HCV prevalence was lower than prison studies. Hispanics had an unexpectedly high rate of chronic hepatitis B infection and had the lowest rate of hepatitis B vaccination. The finding that hepatitis B vaccination coverage among jail entrants is lower than the general population, despite this population's increased risk for infection, highlights the need to support vaccination in jail settings. C1 [Hennessey, Karen A.; Weinbaum, Cindy M.] Ctr Dis Control & Prevent, Div Viral Hepatitis, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, CDC, Atlanta, GA 30333 USA. [Kim, Andrea A.] San Francisco Dept Hlth, San Francisco, CA USA. [Griffin, Vivian] Michigan Dept Community Hlth, Detroit, MI USA. [Collins, Nicoline T.] Chicago Dept Publ Hlth, Chicago, IL USA. [Sabin, Keith] CDC, Global AIDS Program, NCHHSTP, Atlanta, GA 30333 USA. RP Hennessey, KA (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, CDC, 1600 Clifton Rd NE,MS-G37, Atlanta, GA 30333 USA. EM khennessey@cdc.gov OI Sabin, Keith/0000-0002-2290-8621 FU CDC FX CDC funds were used to conduct this study. NR 33 TC 34 Z9 34 U1 1 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1099-3460 J9 J URBAN HEALTH JI J. Urban Health PD JAN PY 2009 VL 86 IS 1 BP 93 EP 105 DI 10.1007/s11524-008-9305-8 PG 13 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 397PK UT WOS:000262674400010 PM 18622707 ER PT J AU Carmichael, SL Yang, W Correa, A Olney, RS Shaw, GM AF Carmichael, Suzan L. Yang, Wei Correa, Adolfo Olney, Richard S. Shaw, Gary M. CA Natl Birth Defects Prevention Stud TI Hypospadias and Intake of Nutrients Related to One-Carbon Metabolism SO JOURNAL OF UROLOGY LA English DT Article DE folic acid; hypospadias; maternal nutrition physiology ID BIRTH-DEFECTS PREVENTION; MINERAL SUPPLEMENT USE; NEURAL-TUBE DEFECTS; ANTIEPILEPTIC DRUGS; FOLIC-ACID; VALPROIC ACID; MALFORMATIONS; VITAMIN; DIET; CRYPTORCHIDISM AB Purpose: We examined whether hypospadias is associated with maternal intake of folic acid containing vitamin/mineral supplements or dietary intake of nutrients related to one-carbon metabolism (folate, choline, vitamins B12 and B6, thiamine, riboflavin, methionine and zinc). Materials and Methods: The study included births from October 1997 to December 2003 that were part of the National Birth Defects Prevention Study. Diet was assessed by food frequency questionnaire during maternal telephone interviews. Analyses included 915 cases with second or third degree hypospadias (urethra opened at the penile shaft, scrotum or perineum) and 2,266 male, liveborn, nonmalformed controls. All ORs and 95% CIs were estimated from logistic regression models that included several potential confounders. Nutrient based analyses also included energy intake. Results: Hypospadias risk was not associated with supplement use (adjusted ORs were 1.2, 95% Cl 0.9-1.6 for intake beginning in the month before or the first month of pregnancy and 1.1, 95% Cl 0.8-1.4 for intake beginning in the second or third month, relative to no intake). Among women who took supplements reduced hypospadias risk was associated with higher dietary intakes of choline, methionine and vitamin B12. The respective ORs (CIS) for the highest vs lowest quartiles were 0.7 (0.5-1.1), 0.6 (0.4-0.9) and 0.7 (0.5-1.0). Among women who did not take supplements increased risk of hypospadias was associated with higher vitamin B12 intake. The OR (101) for the highest vs lowest quartile was 3.1 (1.1-9.0). Conclusions: This study suggests an association of hypospadias with intake of certain nutrients related to one-carbon metabolism. C1 [Carmichael, Suzan L.; Yang, Wei; Shaw, Gary M.] March Dimes Fdn, Calif Res Div, Oakland, CA USA. [Correa, Adolfo; Olney, Richard S.] CDC, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Carmichael, SL (reprint author), Childrens Hosp Oakland, Res Inst, 5700 Martin Luther King Jr Way, Oakland, CA 94609 USA. EM scarmichael@marchofdimes.com RI Publications, NBDPS/B-7692-2013 FU NIDDK NIH HHS [DK56350]; PHS HHS [U50/CCU925286] NR 27 TC 11 Z9 12 U1 2 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD JAN PY 2009 VL 181 IS 1 BP 315 EP 321 DI 10.1016/j.juro.2008.09.041 PG 7 WC Urology & Nephrology SC Urology & Nephrology GA 383WU UT WOS:000261705900175 PM 19013591 ER PT J AU Kotlarz, N Lantagne, D Preston, K Jellison, K AF Kotlarz, Nadine Lantagne, Daniele Preston, Kelsey Jellison, Kristen TI Turbidity and chlorine demand reduction using locally available physical water clarification mechanisms before household chlorination in developing countries SO JOURNAL OF WATER AND HEALTH LA English DT Article DE developing countries; drinking water; household water treatment; point-of-use chlorination; safe water system; water clarification ID RANDOMIZED CONTROLLED-TRIAL; DRINKING-WATER; FLOCCULANT-DISINFECTANT; DIARRHEA PREVENTION; CHILDHOOD DIARRHEA; WESTERN KENYA; SAFE STORAGE; STRATEGIES; COMMUNITY; CHILDREN AB Over 1.1 billion people in the world lack access to improved drinking water. Diarrhoeal and other waterborne diseases cause an estimated 1.9 million deaths per year. The Safe Water System (SWS) is a proven household water treatment intervention that reduces diarrhoeal disease incidence among users in developing countries. Turbid waters pose a particular challenge to implementation of SWS programmes; although research shows that a 3.75mgl(-1) sodium hypochlorite dose effectively treats turbid waters, users sometimes object to the strong chlorine taste and prefer to drink water that is more aesthetically pleasing. This study investigated the efficacy of three locally available water clarification mechanisms-cloth filtration, settling/decanting and sand filtration-to reduce turbidity and chlorine demand at turbidities of 10, 30, 70, 100 and 300 NTU. All three mechanisms reduced turbidity (cloth filtration 21-60%, settling/decanting 78-88% and sand filtration 57-99%). Sand filtration (P = 0.002) and settling/decanting (P = 0.004), but not cloth filtration (P = 0.30), were effective at reducing chlorine demand compared with controls. Recommendations for implementing organizations based on these results are discussed. C1 [Lantagne, Daniele] US Ctr Dis Control & Prevent, Enter Dis Epidemiol Branch, Atlanta, GA 30333 USA. [Kotlarz, Nadine; Preston, Kelsey; Jellison, Kristen] Lehigh Univ, Dept Civil & Environm Engn, Bethlehem, PA 18015 USA. RP Lantagne, D (reprint author), US Ctr Dis Control & Prevent, Enter Dis Epidemiol Branch, 1600 Clifton Rd,MS A38, Atlanta, GA 30333 USA. EM dlantagne@cdc.gov FU National Science Foundation CAREER [0545687] FX This work was partially supported by a National Science Foundation CAREER grant to co-author Jellison (Award # 0545687). NR 23 TC 6 Z9 6 U1 0 U2 9 PU I W A PUBLISHING PI LONDON PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND SN 1477-8920 J9 J WATER HEALTH JI J. Water Health PY 2009 VL 7 IS 3 BP 497 EP 506 DI 10.2166/wh.2009.071 PG 10 WC Environmental Sciences; Public, Environmental & Occupational Health; Microbiology; Water Resources SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Microbiology; Water Resources GA 492BM UT WOS:000269629100013 PM 19491500 ER PT J AU Freeman, MC Quick, RE Abbott, DP Ogutu, P Rheingans, R AF Freeman, Matthew C. Quick, Robert E. Abbott, Daniel P. Ogutu, Paul Rheingans, Richard TI Increasing equity of access to point-of-use water treatment products through social marketing and entrepreneurship: a case study in western Kenya SO JOURNAL OF WATER AND HEALTH LA English DT Article DE equity; point-of-use water treatment; social marketing; water quality ID INSECTICIDE-TREATED NETS; SAFE STORAGE; DIARRHEA PREVENTION; DRINKING-WATER; QUALITY; CONTAMINATION; INTERVENTIONS; CHLORINATION; CHALLENGES; CHILDREN AB Point-of-use water chlorination reduces diarrhoea risk by 25-85%. Social marketing has expanded access to inexpensive sodium hypochlorite for water treatment, at a cost of less than US$0.01 per day, in Kenya. To increase product access, women's groups in western Kenya were trained to educate neighbours and sell health products to generate income. We evaluated this programme's impact on equity of access to water treatment products in a cross-sectional survey. We surveyed 487 randomly selected households in eight communities served by the women's groups. Overall, 20% (range 5-39%) of households in eight communities purchased and used chlorine, as confirmed by residual chlorine observed in stored water. Multivariate models using illiteracy and the poorest socioeconomic status as a referent showed that persons with at least some primary education (OR 2.5, 95% CI 1.8, 3.5) or secondary education (OR 5.4, 95% CI 1.6, 17.5) and persons in the four wealthiest quintiles (OR 2.5, 95% CI 1.0, 6.0) were more likely to chlorinate stored water. While this implementation model was associated with good product penetration and use, barriers to access to inexpensive water treatment remained among the very poor and less educated. C1 [Freeman, Matthew C.; Rheingans, Richard] Emory Univ, Ctr Global Safe Water, Hubert Dept Global Hlth, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Quick, Robert E.] Ctr Dis Control & Prevent, Enter Dis Epidemiol Branch, Div Foodborne Bacterial & Mycot Dis, Atlanta, GA 30333 USA. [Abbott, Daniel P.] Save Children USA, Dept Educ & Child Dev, Washington, DC 20009 USA. [Ogutu, Paul] Great Lakes Univ Kenya, Kisumu 40100, Kenya. RP Freeman, MC (reprint author), Emory Univ, Ctr Global Safe Water, Hubert Dept Global Hlth, Rollins Sch Publ Hlth, 1518 Clifton Rd NE,GCR 767, Atlanta, GA 30322 USA. EM mcfreem@sph.emory.edu FU Emory University Center for Global Safe Water and the United States Agency for International Development FX Financial support for this project was provided by the Eugene J. Gangarosa Fund, the Emory University Center for Global Safe Water and the United States Agency for International Development. We appreciate the logistical support from the CARE Kenya Safe Water Team: Sam Ombeki, John Migele, Alex Mwaki and Mary Ayalo. We thank the members of the communities who graciously agreed to participate in this programme evaluation. NR 25 TC 17 Z9 17 U1 1 U2 13 PU IWA PUBLISHING PI LONDON PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND SN 1477-8920 J9 J WATER HEALTH JI J. Water Health PY 2009 VL 7 IS 3 BP 527 EP 534 DI 10.2166/wh.2009.063 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health; Microbiology; Water Resources SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Microbiology; Water Resources GA 492BM UT WOS:000269629100016 PM 19491503 ER PT J AU Roland, KB Benard, VB Saraiya, M Hawkins, NA Brandt, H Friedman, AL AF Roland, Katherine B. Benard, Vicki B. Saraiya, Mona Hawkins, Nikki A. Brandt, Heather Friedman, Allison L. TI Assessing Cervical Cancer Screening Guidelines in Patient Education Materials SO JOURNAL OF WOMENS HEALTH LA English DT Article ID HUMAN-PAPILLOMAVIRUS INFECTION; HPV VACCINATION; PSYCHOLOGICAL IMPACT; HEALTH INFORMATION; UNITED-STATES; KNOWLEDGE; WOMEN; READABILITY; ATTITUDES; INTERNET AB Background: Adjunct human papillomavirus (HPV) testing with cervical cytology (Pap test) is one option that can increase screening intervals for women aged >= 30 years who have concurrent negative (normal) test results. Previous research suggests that most women are unaware of the relationship between HPV and cervical cancer. In addition, patients often do not understand the significance of their HPV test results, let alone the implications of negative results for future cervical cancer risk or screening options. Patient education materials that explain new screening methods and guidelines for cervical cancer screening with HPV testing can improve resource utilization and support patients making screening decisions. Methods: We identified cervical cancer screening materials published from 2004 through 2006 by U. S. government and nonprofit agencies, pharmaceutical companies, and professional associations via a web-based search. We reviewed those materials for content relating to HPV and HPV testing, screening guidelines, and reading grade level. Results: Eleven patient education materials met selection criteria for this review. Seven materials (five of which were industry sponsored or produced) promoted updated guidelines for women with concurrent negative HPV and cytology test results. The mean reading grade level of materials was found to be approximately ninth grade. Conclusions: This review highlights the need for more comprehensive, plainer language patient education materials that explain new technologies in cervical cancer screening. C1 [Roland, Katherine B.; Benard, Vicki B.; Saraiya, Mona; Hawkins, Nikki A.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Canc Prevent & Control, Atlanta, GA USA. [Brandt, Heather] Univ S Carolina, Arnold Sch Publ Hlth, Dept Hlth Promot Educ & Behav, Columbia, SC 29208 USA. [Friedman, Allison L.] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitus STD & TB Preven, Div Sexually Transmitted Dis Prevent, Atlanta, GA USA. RP Roland, KB (reprint author), 4770 Buford Highway,NE MS K-55, Atlanta, GA 30341 USA. EM kroland@cdc.gov NR 60 TC 6 Z9 6 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 J9 J WOMENS HEALTH JI J. Womens Health PD JAN PY 2009 VL 18 IS 1 BP 5 EP 12 DI 10.1089/jwh.2008.1211 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA 395AX UT WOS:000262495500001 ER PT J AU Penninx, BWJH Nicklas, BJ Newman, AB Harris, TB Goodpaster, BH Satterfield, S de Rekeneire, N Yaffe, K Pahor, M Kritchevsky, SB AF Penninx, Brenda W. J. H. Nicklas, Barbara J. Newman, Anne B. Harris, Tamara B. Goodpaster, Bret H. Satterfield, Suzanne de Rekeneire, Nathalie Yaffe, Kristine Pahor, Marco Kritchevsky, Stephen B. CA Hlth ABC Study TI Metabolic Syndrome and Physical Decline in Older Persons: Results from the Health, Aging and Body Composition Study SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES LA English DT Article DE Metabolic syndrome; Obesity; Glucose; Mobility limitation; Older; Diabetes; Cerebrovascular disease ID C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; ASSOCIATION; OBESITY; RISK; COHORT; WOMEN; MEN; STRENGTH AB Background. The metabolic syndrome includes dyslipidemia, abdominal obesity, insulin resistance, and hypertension and is associated with an increased risk of diabetes and cerebrovascular disease (CVD), but consequences beyond these outcomes have not been examined extensively. We investigated whether metabolic abnormalities have independent consequences on loss of mobility function of older persons. Methods. Data are from 2,920 men and women, 70-79 years, participating in the Health ABC study without mobility limitations at baseline. Metabolic syndrome was defined as >= 3 of the following: (a) waist circumference >102 (men) or >88 cm (women); (b) triglycerides >= 150 mg/dL; (c) high-density lipoprotein cholesterol <40 mg/dL (men) or <50 mg/dL (women); (d) blood pressure >= 130/85 mm Hg or antihypertensive medication; and (d) fasting glucose >= 110 mg/dL or antidiabetic medication. Mobility limitation was defined as difficulty or inability walking mile or climbing 10 steps during two consecutive semiannual assessments over 4.5 years. Results. The prevalence of metabolic syndrome was 38.6%. The metabolic syndrome was associated with an adjusted relative risk (RR) of 1.46 (95% confidence interval [CI] = 1.30-1.63) for developing mobility limitations. The risk increased when more metabolic syndrome components were present (p trend > .001). All metabolic syndrome components were significantly associated with incident mobility limitations with the highest RRs for abdominal obesity (RR = 1.54, 95% CI = 1.35-1.75) and hyperglycemia (RR = 1.44, 95% CI = 1.27-1.63). Findings were unchanged when persons with baseline, or incident, CVD, stroke, or diabetes were excluded. Conclusions. Metabolic syndrome abnormalities, especially abdominal obesity and hyperglycemia, are predictive of mobility limitations in the elderly, independent of CVD or diabetes. C1 [Penninx, Brenda W. J. H.] Vrije Univ Amsterdam Med Ctr, EMGO Inst, Dept Psychiat, NL-1081 HL Amsterdam, Netherlands. [Nicklas, Barbara J.; Kritchevsky, Stephen B.] Wake Forest Univ, Bowman Gray Sch Med, Sticht Ctr Aging, Winston Salem, NC USA. [Newman, Anne B.; Goodpaster, Bret H.] Univ Pittsburgh, Pittsburgh, PA 15260 USA. [Harris, Tamara B.] NIA, Bethesda, MD 20892 USA. [Satterfield, Suzanne] Univ Tennessee, Memphis, TN USA. [de Rekeneire, Nathalie] Ctr Dis Control, Atlanta, GA 30333 USA. [Yaffe, Kristine] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Pahor, Marco] Univ Florida, Gainesville, FL USA. RP Penninx, BWJH (reprint author), Vrije Univ Amsterdam Med Ctr, EMGO Inst, Dept Psychiat, AJ Ernststr 887, NL-1081 HL Amsterdam, Netherlands. EM b.penninx@vumc.nl RI Newman, Anne/C-6408-2013; OI Newman, Anne/0000-0002-0106-1150; Kritchevsky, Stephen/0000-0003-3336-6781 FU Intramural NIH HHS; NHLBI NIH HHS [R01 HL072972, 1R01-HL72972]; NIA NIH HHS [N01-AG-6-2106, P30 AG021332, P30 AG028740, N01-AG-6-2103, N01-AG-6-2101] NR 30 TC 35 Z9 36 U1 0 U2 2 PU GERONTOLOGICAL SOC AMER PI WASHINGTON PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA SN 1079-5006 J9 J GERONTOL A-BIOL JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci. PD JAN PY 2009 VL 64 IS 1 BP 96 EP 102 DI 10.1093/gerona/gln005 PG 7 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 418ZY UT WOS:000264190100011 PM 19164274 ER PT J AU Guarner, J Bhatnagar, J Jones, T Schemankewitz, E Zaki, SR AF Guarner, J. Bhatnagar, J. Jones, T. Schemankewitz, E. Zaki, S. R. TI Detection of Clostridium difficile Toxins in Stools and Presence of the Bacteria in Tissues in a Pediatric Population SO LABORATORY INVESTIGATION LA English DT Meeting Abstract CT 98th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology CY MAR 07-13, 2009 CL Boston, MA SP US & Canadian Acad Pathol C1 Emory Univ, Atlanta, GA 30322 USA. Ctr Dis Control & Prevent, Atlanta, GA USA. Childrens Healthcare Atlanta, Atlanta, GA USA. RI Guarner, Jeannette/B-8273-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD JAN PY 2009 VL 89 MA 1333 BP 294A EP 295A PG 2 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA 394XK UT WOS:000262486301333 ER PT J AU Shieh, WJ Chris, P Guarner, J Zaki, SR AF Shieh, W-J Chris, P. Guarner, J. Zaki, S. R. TI Pathologic Studies of Leptospirosis, Ten-Years Experience at Centers for Disease Control and Prevention SO LABORATORY INVESTIGATION LA English DT Meeting Abstract CT 98th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology CY MAR 07-13, 2009 CL Boston, MA SP US & Canadian Acad Pathol C1 Ctr Dis Control & Prevent, Atlanta, GA USA. Emory Univ, Childrens Hosp Atlanta, Atlanta, GA 30322 USA. RI Guarner, Jeannette/B-8273-2013 NR 0 TC 0 Z9 0 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD JAN PY 2009 VL 89 MA 1347 BP 298A EP 298A PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA 394XK UT WOS:000262486301347 ER PT J AU Elias, C Okwo-Bele, JM Fischer, M AF Elias, Chris Okwo-Bele, Jean Marie Fischer, Marc TI A strategic plan for Japanese encephalitis control by 2015 SO LANCET INFECTIOUS DISEASES LA English DT Letter C1 [Elias, Chris] PATH, Seattle, WA USA. WHO, CH-1211 Geneva, Switzerland. Ctr Dis Control & Prevent, Arboviral Dis Branch, Div Vector Borne Infect Dis, Atlanta, GA USA. RP Elias, C (reprint author), PATH, Seattle, WA USA. EM celias@path.org NR 1 TC 11 Z9 14 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1473-3099 J9 LANCET INFECT DIS JI Lancet Infect. Dis. PD JAN PY 2009 VL 9 IS 1 BP 7 EP 7 PG 1 WC Infectious Diseases SC Infectious Diseases GA 387IH UT WOS:000261944400006 PM 19095192 ER PT J AU Friese, CR Abel, GA Magazu, LS Neville, BA Richardson, LC Earle, CC AF Friese, Christopher R. Abel, Gregory A. Magazu, Lysa S. Neville, Bridget A. Richardson, Lisa C. Earle, Craig C. TI Diagnostic delay and complications for older adults with multiple myeloma SO LEUKEMIA & LYMPHOMA LA English DT Article CT 49th Annual Meeting of the American-Society-of-Hematology CY DEC 08-11, 2007 CL Atlanta, GA SP Amer Soc Hematol DE Multiple myeloma; diagnostic delay; health services research; quality of care ID ACUTE MYOCARDIAL-INFARCTION; FAMILY PHYSICIANS KNOWLEDGE; CANCER REFERRAL GUIDELINES; GENDER-DIFFERENCES; NATIONAL-SURVEY; BREAST-CANCER; NHS-PATIENTS; PRIMARY-CARE; SYMPTOMS; STAGE AB Increased attention to timely diagnosis motivated us to study 5483 patients diagnosed with multiple myeloma using Medicare claims linked to tumor registries in the Surveillance, Epidemiology and End Results programme. We calculated the time between initial visits for anemia or back pain and for myeloma diagnosis, and used logistic regression to predict the likelihood of diagnostic delay, and also the likelihood of renal or skeletal complications. The median time between sign or symptom and myeloma diagnosis was 99 days. Patients with anemia, back pain and comorbidities were more likely to experience diagnostic delay (OR 1.6, 95% CI 1.3-2.0). Diagnosis while hospitalised (OR 2.5, 95% CI 2.2-2.9) and chemotherapy treatment within 6 months of diagnosis (OR 1.4, 95% CI 1.2-1.6) significantly predicted complications; diagnostic delay did not (OR 0.9, 95% CI 0.8-1.1). Our data suggest that complications are more strongly associated with health status and myeloma severity than with diagnostic delays. C1 [Earle, Craig C.] Sunnybrook Hlth Sci Ctr, Inst Clin Evaluat Sci, Toronto, ON M4N 3M5, Canada. [Friese, Christopher R.] Univ Michigan, Sch Nursing, Ann Arbor, MI 48109 USA. [Abel, Gregory A.; Magazu, Lysa S.; Neville, Bridget A.] Dana Farber Canc Inst, Ctr Outcomes & Policy Res, Boston, MA 02115 USA. [Abel, Gregory A.] Harvard Univ, Sch Med, Dept Med, Div Med Oncol, Boston, MA USA. [Richardson, Lisa C.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA USA. RP Earle, CC (reprint author), Sunnybrook Hlth Sci Ctr, Inst Clin Evaluat Sci, 2075 Bayview Ave,Room G-106, Toronto, ON M4N 3M5, Canada. EM craig.earle@ices.on.ca RI Friese, Christopher/D-2097-2013 OI Friese, Christopher/0000-0002-2281-2056 FU NCI NIH HHS [R25 CA 057711-12, R25 CA057711, T32 CA009172]; NINR NIH HHS [K99 NR010750, K99 NR010750-02, R00 NR010750]; PHS HHS [200-2002-00575] NR 48 TC 17 Z9 17 U1 0 U2 5 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1042-8194 J9 LEUKEMIA LYMPHOMA JI Leuk. Lymphoma PY 2009 VL 50 IS 3 BP 392 EP 400 AR PII 909597695 DI 10.1080/10428190902741471 PG 9 WC Oncology; Hematology SC Oncology; Hematology GA 435RN UT WOS:000265361100018 PM 19294556 ER PT J AU Benedict, MQ Knols, BGJ Bossin, HC Howell, PI Mialhe, E Caceres, C Robinson, AS AF Benedict, Mark Q. Knols, Bart G. J. Bossin, Herve C. Howell, Paul I. Mialhe, Eric Caceres, Carlos Robinson, Alan S. TI Colonisation and mass rearing: learning from others SO MALARIA JOURNAL LA English DT Review ID ANOPHELES-STEPHENSI DIPTERA; STERILE INSECT TECHNIQUE; DEFINED DIETARY MEDIA; MATING COMPETITIVENESS; MOSQUITO LARVAE; AEDES-AEGYPTI; CULICIDAE; GAMBIAE; FIELD; STRAIN AB Mosquitoes, just as other insects produced for the sterile insect technique (SIT), are subjected to several unnatural processes including laboratory colonisation and large-scale factory production. After these processes, sterile male mosquitoes must perform the natural task of locating and mating with wild females. Therefore, the colonisation and production processes must preserve characters necessary for these functions. Fortunately, in contrast to natural selection which favours a suite of characteristics that improve overall fitness, colonisation and production practices for SIT strive to maximize only the few qualities that are necessary to effectively control populations. However, there is considerable uncertainty about some of the appropriate characteristics due to the lack of data. Development of biological products for other applications suggest that it is possible to identify and modify competitiveness characteristics in order to produce competitive mass produced sterile mosquitoes. This goal has been pursued - and sometimes achieved - by mosquito colonisation, production, and studies that have linked these characteristics to field performance. Parallels are drawn to studies in other insect SIT programmes and aquaculture which serve as vital technical reference points for mass-production of mosquitoes, most of whose development occurs - and characteristics of which are determined - in an aquatic environment. Poorly understood areas that require further study are numerous: diet, mass handling and genetic and physiological factors that influence mating competitiveness. Compromises in such traits due to demands to increase numbers or reduce costs, should be carefully considered in light of the desired field performance. C1 [Benedict, Mark Q.; Robinson, Alan S.] IAEA, FAO IAEA Agr & Biotechnol Lab, Entomol Unit, A-2444 Seibersdorf, Austria. [Knols, Bart G. J.] Univ Amsterdam, Acad Med Ctr, Div Infect Dis Trop Med & AIDS, NL-1105 AZ Amsterdam, Netherlands. [Knols, Bart G. J.] K&S Consulting, NL-6669 CP Dodewaard, Netherlands. [Bossin, Herve C.] Inst Louis Malard, F-98713 Papeete, Tahiti, Fr Polynesia. [Howell, Paul I.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Howell, Paul I.] Atlanta Res & Educ Fdn, Atlanta, GA 30341 USA. [Mialhe, Eric] Concepto Azul SA, Guayaquil, Ecuador. [Mialhe, Eric] Univ Guayaquil, Guayaquil, Ecuador. [Caceres, Carlos] USDA, APHIS, Guatemala City 01010, Guatemala. RP Benedict, MQ (reprint author), IAEA, FAO IAEA Agr & Biotechnol Lab, Entomol Unit, A-2444 Seibersdorf, Austria. EM mqbenedict@yahoo.com; bart@malaria-world.com; hbossin-ilm@mail.pf; PHowell1@cdc.gov; Ericmialhe@yahoo.fr; carlos.e.caceres@usda.aphis.gov; A.S.Robinson@iaea.org RI Knols, Bart/C-5765-2017; OI BOSSIN, Herve/0000-0002-3655-0923 NR 58 TC 41 Z9 41 U1 3 U2 16 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PY 2009 VL 8 SU 2 AR S4 DI 10.1186/1475-2875-8-S2-S4 PG 11 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 602UP UT WOS:000278164700005 PM 19917074 ER PT J AU Howell, PI Knols, BGJ AF Howell, Paul I. Knols, Bart G. J. TI Male mating biology SO MALARIA JOURNAL LA English DT Review ID ANOPHELES-GAMBIAE MOSQUITOS; STERILE INSECT TECHNIQUE; ANTENNAL HAIR ERECTION; CULEX-TARSALIS DIPTERA; MALARIA VECTOR CONTROL; MOLECULAR M-FORM; CULICIFACIES GILES; COMPLEX DIPTERA; CHEMOSTERILIZED MALES; BACTROCERA-CUCURBITAE AB Before sterile mass-reared mosquitoes are released in an attempt to control local populations, many facets of male mating biology need to be elucidated. Large knowledge gaps exist in how both sexes meet in space and time, the correlation of male size and mating success and in which arenas matings are successful. Previous failures in mosquito sterile insect technique (SIT) projects have been linked to poor knowledge of local mating behaviours or the selection of deleterious phenotypes during colonisation and long-term mass rearing. Careful selection of mating characteristics must be combined with intensive field trials to ensure phenotypic characters are not antagonistic to longevity, dispersal, or mating behaviours in released males. Success has been achieved, even when colonised vectors were less competitive, due in part to extensive field trials to ensure mating compatibility and effective dispersal. The study of male mating biology in other dipterans has improved the success of operational SIT programmes. Contributing factors include inter-sexual selection, pheromone based attraction, the ability to detect alterations in local mating behaviours, and the effects of long-term colonisation on mating competitiveness. Although great strides have been made in other SIT programmes, this knowledge may not be germane to anophelines, and this has led to a recent increase in research in this area. C1 [Howell, Paul I.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Howell, Paul I.] Malaria Res & Reference Reagent Resource Ctr MR4, Decatur, GA 30033 USA. [Howell, Paul I.] Atlanta Res & Educ Fdn AREF, Decatur, GA 30033 USA. [Howell, Paul I.; Knols, Bart G. J.] Univ Amsterdam, Acad Med Ctr, Div Infect Dis Trop Med & AIDS, NL-1105 AZ Amsterdam, Netherlands. [Howell, Paul I.; Knols, Bart G. J.] K&S Consulting, NL-6669 CP Dodewaard, Netherlands. RP Howell, PI (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy, Atlanta, GA 30341 USA. EM bsr7@cdc.gov; bart@malaria-world.com RI Knols, Bart/C-5765-2017 NR 98 TC 36 Z9 36 U1 0 U2 19 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PY 2009 VL 8 SU 2 AR S8 DI 10.1186/1475-2875-8-S2-S8 PG 10 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 602UP UT WOS:000278164700009 PM 19917078 ER PT J AU Nuru-Jeter, A Dominguez, T Hammond, W Leu, JX Skaff, M Egerter, S Jones, C Braveman, P AF Nuru-Jeter, Amani Dominguez, Tyan Parker Hammond, Wizdom Powell Leu, Janxin Skaff, Marilyn Egerter, Susan Jones, Camara P. Braveman, Paula TI "It's The Skin You're In": African-American Women Talk About Their Experiences of Racism. An Exploratory Study to Develop Measures of Racism for Birth Outcome Studies SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Race; Racism; Birth outcomes; African-American women ID BORN BLACK-WOMEN; PRETERM BIRTH; UNITED-STATES; RISK-FACTORS; CARDIOVASCULAR-DISEASE; SOCIOECONOMIC-STATUS; ALLOSTATIC LOAD; LIFE EVENTS; WEIGHT; DISCRIMINATION AB Objectives Stress due to experiences of racism could contribute to African-American women's adverse birth outcomes, but systematic efforts to measure relevant experiences among childbearing women have been limited. We explored the racism experiences of childbearing African-American women to inform subsequent development of improved measures for birth outcomes research. Methods Six focus groups were conducted with a total of 40 socioeconomically diverse African-American women of childbearing age in four northern California cities. Results Women reported experiencing racism (1) throughout the lifecourse, with childhood experiences seeming particularly salient and to have especially enduring effects (2) directly and vicariously, particularly in relation to their children; (3) in interpersonal, institutional, and internalized forms; (4) across different life domains; (5) with active and passive responses; and (6) with pervasive vigilance, anticipating threats to themselves and their children. Conclusions This exploratory study's findings support the need for measures reflecting the complexity of childbearing African-American women's racism experiences. In addition to discrete, interpersonal experiences across multiple domains and active/passive responses, which have been measured, birth outcomes research should also measure women's childhood experiences and their potentially enduring impact, perceptions of institutionalized racism and internalized negative stereotypes, vicarious experiences related to their children, vigilance in anticipating future racism events, as well as the pervasiveness and chronicity of racism exposure, all of which could be sources of ongoing stress with potentially serious implications for birth outcomes. Measures of racism addressing these issues should be developed and formally tested. C1 [Egerter, Susan; Braveman, Paula] Univ Calif San Francisco, Dept Family & Commun, San Francisco, CA 94118 USA. [Egerter, Susan; Braveman, Paula] Univ Calif San Francisco, Ctr Social Dispar Hlth, San Francisco, CA 94118 USA. [Nuru-Jeter, Amani] Univ Calif Berkeley, Div Commun Hlth & Human Dev, Berkeley, CA 94720 USA. [Nuru-Jeter, Amani] Univ Calif Berkeley, Div Epidemiol, Sch Publ Hlth, Berkeley, CA 94720 USA. [Dominguez, Tyan Parker] Univ So Calif, Sch Social Work, Los Angeles, CA 90089 USA. [Hammond, Wizdom Powell] Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC 27599 USA. [Leu, Janxin] Univ Washington, Dept Psychol, Seattle, WA 98195 USA. [Skaff, Marilyn] Univ Calif San Francisco, Dept Family & Community Med, San Francisco, CA 94118 USA. [Jones, Camara P.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Adult & Community Hlth, Atlanta, GA 30341 USA. RP Braveman, P (reprint author), Univ Calif San Francisco, Dept Family & Commun, 3333 Calif St,Suite 365,Box 0943, San Francisco, CA 94118 USA. EM anjeter@berkeley.edu; tyanpark@usc.edu; wizdomp@email.unc.edu; janleu@uwashington.edu; skaffm@fcm.ucsf.edu; egerters@fcm.ucsf.edu; cdj9@cdc.gov; Braveman@fcm.ucsf.edu FU ATSDR CDC HHS [TS-842]; NICHD NIH HHS [R24 HD042828, R24 HD042828-10]; NIMHD NIH HHS [L60 MD002605-01] NR 72 TC 47 Z9 47 U1 2 U2 18 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD JAN PY 2009 VL 13 IS 1 BP 29 EP 39 DI 10.1007/s10995-008-0357-x PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 385RV UT WOS:000261832200004 PM 18463971 ER PT J AU Raymond, JS Anderson, R Feingold, M Homa, D Brown, MJ AF Raymond, Jaime S. Anderson, Roberta Feingold, Mark Homa, David Brown, Mary Jean TI Risk for Elevated Blood Lead Levels in 3-and 4-Year-Old Children SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Childhood lead poisoning; Late onset lead poisoning; Case control study; Clinical risk factors ID IRON-DEFICIENCY; NATIONAL-HEALTH; EXPOSURE; ACHIEVEMENT; NHANES; AGE AB Objective We conducted a study to evaluate the relation between environmental, demographic, and medical risk factors and late-onset childhood lead poisoning, defined as children who were poisoned at age 3 or older. Methods We performed a retrospective case-control study of 262 children whose test results showed non-elevated (< 10 mu g/dl) blood lead levels (BLLs) before age 2 but levels a parts per thousand yen10 mu g/dl after age 3 and of 300 control children who had non-elevated BLL test results before age 2 and also after age 3. The target population was children receiving care at MetroHealth Medical Center in Cleveland, OH. We modeled the association between demographic and clinical risk factors and BLLs a parts per thousand yen10 mu g/dl after age 3. Covariates considered were race, gender, body mass index, immunization status, mean corpuscular volume, hematocrit, red cell volume distribution width (RDW), red blood count, hemoglobin, baseline BLL result, and time between the baseline and second BLL test. Results Case children were more likely to be male (P < 0.0001), black (P = 0.0189) and to have a high RDW defined as a parts per thousand yen14.5 % (P = 0.0083). On the basis of the final model, children with BLLs 7-9 mu g/dl before age 2 and again after a follow-up BLL test (< 21 months) were more likely to become lead poisoned than were control children. The risk of black children developing lead poisoning increased over time, regardless of the child's first BLL test result. Conclusions Although national recommendations are to test children's blood lead levels at ages 1 and 2, children living in high-risk areas with such risk factors should have a blood lead test at these older ages. C1 [Raymond, Jaime S.; Homa, David; Brown, Mary Jean] Div Emergency & Environm Hlth Services, Lead Poisoning Prevent Branch, Natl Ctr Environm Hlth, Centers Dis Control & Prevent, Atlanta, GA 30341 USA. [Anderson, Roberta; Feingold, Mark] MetroHealth Med Ctr, Cleveland, OH 44109 USA. [Raymond, Jaime S.; Homa, David; Brown, Mary Jean] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Emergency & Environm Hlth Serv, Lead Poisoning Prevent Branch, Atlanta, GA 30341 USA. [Anderson, Roberta; Feingold, Mark] Metrohlth Med Ctr, Cleveland, OH 44109 USA. RP Raymond, JS (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Emergency & Environm Hlth Serv, Lead Poisoning Prevent Branch, 4770 Buford Hwy,MS F-40, Atlanta, GA 30341 USA. EM zvu0@cdc.gov NR 32 TC 10 Z9 10 U1 0 U2 4 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 EI 1573-6628 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD JAN PY 2009 VL 13 IS 1 BP 40 EP 47 DI 10.1007/s10995-007-0297-x PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 385RV UT WOS:000261832200005 PM 17963029 ER PT S AU Rota, PA Featherstone, DA Bellini, WJ AF Rota, P. A. Featherstone, D. A. Bellini, W. J. BE Griffin, DE Oldstone, MBA TI Molecular Epidemiology of Measles Virus SO MEASLES: PATHOGENESIS AND CONTROL SE Current Topics in Microbiology and Immunology LA English DT Review ID SUBACUTE SCLEROSING-PANENCEPHALITIS; EDMONSTON VACCINE LINEAGE; REPUBLIC-OF-CHINA; CURRENT WILD-TYPE; SEQUENCE-ANALYSIS; GENETIC-CHARACTERIZATION; ANTIGENIC ANALYSIS; UNITED-STATES; GEOGRAPHICAL-DISTRIBUTION; CLINICAL SPECIMENS AB Genetic characterization of wild-type measles viruses provides a means to study the transmission pathways of the virus and is an essential component of laboratory-based surveillance. Laboratory-based surveillance for measles and rubella, including genetic characterization of wild-type viruses, is performed throughout the world by the WHO Measles and Rubella Laboratory Network, which serves 166 countries in all WHO regions. In particular, the genetic data can help confirm the sources of virus or suggest a source for unknown-source cases as well as to establish links, or lack thereof, between various cases and outbreaks. Virologic surveillance has helped to document the interruption of transmission of endemic measles in some regions. Thus, molecular characterization of measles viruses has provided a valuable tool for measuring the effectiveness of measles control programs, and virologic surveillance needs to be expanded in all areas of the world and conducted during all phases of measles control. C1 [Rota, P. A.] Ctr Dis Control & Prevent, Rubella & Herpesvirus Lab Branch, Atlanta, GA 30333 USA. RP Rota, PA (reprint author), Ctr Dis Control & Prevent, Rubella & Herpesvirus Lab Branch, Atlanta, GA 30333 USA. EM prota@cdc.gov NR 111 TC 68 Z9 72 U1 1 U2 8 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0070-217X BN 978-3-540-70616-8 J9 CURR TOP MICROBIOL JI Curr.Top.Microbiol.Immunol. PY 2009 VL 330 BP 129 EP 150 PG 22 WC Immunology; Microbiology SC Immunology; Microbiology GA BIR26 UT WOS:000262126800007 PM 19203108 ER PT J AU Tilford, JM Grosse, SD Goodman, AC Li, KM AF Tilford, John M. Grosse, Scott D. Goodman, Allen C. Li, Kemeng TI Labor Market Productivity Costs for Caregivers of Children with Spina Bifida: A Population-Based Analysis SO MEDICAL DECISION MAKING LA English DT Article DE lifetime costs; productivity; cost-effectiveness analysis; disability; children ID NEURAL-TUBE DEFECTS; FOLIC-ACID FORTIFICATION; OF-THE-LITERATURE; TIME USE SURVEY; ECONOMIC-ANALYSIS; BREAST-CANCER; UNITED-STATES; HEALTH; CARE; PREVENTION AB Background. Caregiver productivity costs are an important component of the overall cost of care for individuals with birth defects and developmental disabilities, yet few studies provide estimates for use in economic evaluations. Objective. This study estimates labor market productivity costs for caregivers of children and adolescents with spina bifida. Methods. Case families were recruited from a state birth defects registry in Arkansas. Primary caregivers of children with spina bifida (N=98) reported their employment status in the past year and demographic characteristics. Controls were abstracted from the Current Population Survey covering the state of Arkansas for the same time period (N=416). Estimates from regression analyses of labor market outcomes were used to calculate differences in hours worked per week and lifetime costs. Results. Caregivers of children with spina bifida worked an annual average of 7.5 to 11.3 hours less per week depending on the disability severity. Differences in work hours by caregivers of children with spina bifida translated into lifetime costs of $133,755 in 2002 dollars using a 3% discount rate and an age-and sex-adjusted earnings profile. Including caregivers' labor market productivity costs in prevention effectiveness estimates raises the net cost savings per averted case of spina bifida by 48% over the medical care costs alone. Conclusions. Information on labor market productivity costs for caregivers can be used to better inform economic evaluations of prevention and treatment strategies for spina bifida. Cost-effectiveness calculations that omit caregiver productivity costs substantially overstate the net costs of the intervention and underestimate societal value. C1 [Tilford, John M.] Univ Arkansas Med Sci, Coll Med, Ctr Appl Res & Evaluat, Little Rock, AR 72202 USA. [Tilford, John M.] Arkansas Childrens Hosp, Little Rock, AR 72202 USA. [Grosse, Scott D.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Goodman, Allen C.; Li, Kemeng] Wayne State Univ, Dept Econ, Detroit, MI USA. RP Tilford, JM (reprint author), Univ Arkansas Med Sci, Coll Med, Ctr Appl Res & Evaluat, 800 Marshall St, Little Rock, AR 72202 USA. EM tilfordmickj@uams.edu FU Centers for Disease Control and Prevention (CDC) [U50/CCU613236]; Dean's Research and Development Fund at the University of Arkansas for Medical Sciences FX Financial support for this study was provided in part by a cooperative agreement No. U50/CCU613236 from the Centers for Disease Control and Prevention (CDC) and a grant from the Dean's Research and Development Fund at the University of Arkansas for Medical Sciences. The contents are solely the responsibility of the authors and do not represent the official views of the CDC. The funding agreements ensured the authors' independence in designing the study, interpreting the data, writing, and publishing the report. The following authors are employed by the funding sources: John M. Tilford and Scott D. Grosse. Revision accepted for publication 19 May 2008. NR 45 TC 13 Z9 13 U1 1 U2 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0272-989X J9 MED DECIS MAKING JI Med. Decis. Mak. PD JAN-FEB PY 2009 VL 29 IS 1 BP 23 EP 32 DI 10.1177/0272989X08322014 PG 10 WC Health Care Sciences & Services; Medical Informatics SC Health Care Sciences & Services; Medical Informatics GA 421KD UT WOS:000264356900003 PM 18725406 ER PT J AU Balajee, SA AF Balajee, S. Arunmozhi TI Aspergillus terreus complex SO MEDICAL MYCOLOGY LA English DT Article DE Aspergillus terreus; accessory conidia; cryptic species ID AMPHOTERICIN-B; FUNGICIDAL ACTIVITIES; A-FUMIGATUS; VORICONAZOLE; STRAINS; PCR; IDENTIFICATION; EPIDEMIOLOGY; ITRACONAZOLE; INFECTIONS AB Aspergillus terreus can cause invasive infections in humans, which are often refractory to therapy with the antifungal drug amphotericin B and have a propensity to dissemination. The organism has diverse colony morphology, and sub-typing studies have demonstrated that isolates of A. terreus are diverse in their genotypes. However, detailed phylogenetic studies of section Terrei employing sequence information from protein coding regions have not been thus far attempted. Interestingly, A. terreus produces unicellular forms called accessory conidia in vitro and during infection; the clinical relevance of these structures are not well understood. This paper presents an overview of the morphology, species identification strategies, and molecular epidemiology of A. terreus. C1 [Balajee, S. Arunmozhi] Ctr Dis Coent Atlanta, Mycot Dis Branch, Atlanta, GA USA. RP Balajee, SA (reprint author), Ctr Dis Control & Prevent, Mycot Dis Branch, Mail Stop G 11 1600,Clifton Rd, Atlanta, GA 30333 USA. EM fir3@cdc.gov NR 27 TC 24 Z9 25 U1 0 U2 3 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1369-3786 J9 MED MYCOL JI Med. Mycol. PY 2009 VL 47 BP S42 EP S46 AR PII 909588763 DI 10.1080/13693780802562092 PG 5 WC Infectious Diseases; Mycology; Veterinary Sciences SC Infectious Diseases; Mycology; Veterinary Sciences GA 435RZ UT WOS:000265362300007 PM 19291598 ER PT J AU Bearden, SW Sexton, C Pare, J Fowler, JM Arvidson, CG Yerman, L Viola, RE Brubaker, RR AF Bearden, Scott W. Sexton, Christopher Pare, Joshua Fowler, Janet M. Arvidson, Cindy G. Yerman, Lyudmyla Viola, Ronald E. Brubaker, Robert R. TI Attenuated enzootic (pestoides) isolates of Yersinia pestis express active aspartase SO MICROBIOLOGY-SGM LA English DT Article ID COMPLETE GENOME SEQUENCE; PASTEURELLA-PESTIS; GLUCOSE-6-PHOSPHATE DEHYDROGENASE; PLASMINOGEN-ACTIVATOR; PIGMENTATION LOCUS; CAUSATIVE AGENT; PLATING MEDIUM; MUTATION RATE; PLAGUE; PSEUDOTUBERCULOSIS AB It is established that Yersinia pestis, the causative agent of bubonic plague, recently evolved from enteropathogenic Yersinia pseudotuberculosis by undergoing chromosomal degeneration while acquiring two unique plasmids that facilitate tissue invasion (pPCP) and dissemination by fleabite (pMT). Thereafter, plague bacilli spread from central Asia to sylvatic foci throughout the world. These epidemic isolates exhibit a broad host range including man as opposed to enzootic (pestoides) variants that remain in ancient reservoirs where infection is limited to muroid rodents. Cells of Y. pseudotuberculosis are known to express glucose-6-phosphate dehydrogenase (Zwf) and aspartase (AspA); these activities are not detectable in epidemic Y. pestis due to missense mutations (substitution of proline for serine at amino position 155 of Zwf and leucine for valine at position 363 of AspA). In this study, functional Zwf was found in pestoides strains E, F and G but not seven other enzootic isolates; enzymic activity was associated with retention of serine at amino acid position 155. Essentially, full AspA activity occurred in pestoides isolates where valine (pestoides A, B, C and D) or serine (pestoides E, F, G and 1) occupied position 363. Reduced activity occurred in strains Angola and A16, which contained phenylalanine at this position. The k(cat) but not K-m of purified AspA from strain Angola was significantly reduced. In this context, aspA of the recently described attenuated enzootic microtus biovar encodes active valine at position 363, further indicating that functional AspA is a biomarker for avirulence of Y. pestis in man. C1 [Brubaker, Robert R.] Univ Chicago, Dept Microbiol, Chicago, IL 60637 USA. [Bearden, Scott W.; Sexton, Christopher] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Bacterial Dis Branch, Ft Collins, CO 80521 USA. [Pare, Joshua; Fowler, Janet M.; Arvidson, Cindy G.] Michigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA. [Yerman, Lyudmyla; Viola, Ronald E.] Univ Toledo, Dept Chem, Toledo, OH 43606 USA. RP Brubaker, RR (reprint author), Univ Chicago, Dept Microbiol, 920 E 58th St, Chicago, IL 60637 USA. EM t-rbruba@bsd.uchicago.edu RI Viola, Ronald/C-5904-2011 FU NIH [IU54-AI-057153] FX This work was sponsored by the NIH/NIAID Regional Center of Excellence for Bio-defense and Emerging Infectious Diseases Research (RCE) Program. R. R. B. wishes to acknowledge membership within and support from the Region V 'Great Likes' RCE (NIH award IU54-AI-057153). NR 81 TC 21 Z9 25 U1 1 U2 1 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 1350-0872 J9 MICROBIOL-SGM JI Microbiology-(UK) PD JAN PY 2009 VL 155 BP 198 EP 209 DI 10.1099/mic.0.021170-0 PN 1 PG 12 WC Microbiology SC Microbiology GA 398KG UT WOS:000262730400021 PM 19118360 ER PT J AU Guarner, J Bhatnagar, J Jones, T Schemankewitz, E Zaki, SR AF Guarner, J. Bhatnagar, J. Jones, T. Schemankewitz, E. Zaki, S. R. TI Detection of Clostridium difficile Toxins in Stools and Presence of the Bacteria in Tissues in a Pediatric Population SO MODERN PATHOLOGY LA English DT Meeting Abstract CT 98th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology CY MAR 07-13, 2009 CL Boston, MA SP US & Canadian Acad Pathol C1 Emory Univ, Atlanta, GA 30322 USA. Ctr Dis Control & Prevent, Atlanta, GA USA. Childrens Healthcare Atlanta, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0893-3952 J9 MODERN PATHOL JI Mod. Pathol. PD JAN PY 2009 VL 22 MA 1333 BP 294A EP 295A PG 2 WC Pathology SC Pathology GA 393KF UT WOS:000262371501333 ER PT J AU Shieh, WJ Chris, P Guarner, J Zaki, SR AF Shieh, W-J Chris, P. Guarner, J. Zaki, S. R. TI Pathologic Studies of Leptospirosis, Ten-Years Experience at Centers for Disease Control and Prevention SO MODERN PATHOLOGY LA English DT Meeting Abstract CT 98th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology CY MAR 07-13, 2009 CL Boston, MA SP US & Canadian Acad Pathol C1 Ctr Dis Control & Prevent, Atlanta, GA USA. Emory Univ, Childrens Hosp Atlanta, Atlanta, GA 30322 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0893-3952 J9 MODERN PATHOL JI Mod. Pathol. PD JAN PY 2009 VL 22 MA 1347 BP 298A EP 298A PG 1 WC Pathology SC Pathology GA 393KF UT WOS:000262371501347 ER PT J AU Kent, RJ AF Kent, Rebekah J. TI Molecular methods for arthropod bloodmeal identification and applications to ecological and vector-borne disease studies SO MOLECULAR ECOLOGY RESOURCES LA English DT Review DE bloodmeal; DNA barcoding; heteroduplex analysis; microsatellites; PCR; RFLP ID WEST-NILE-VIRUS; HOST-FEEDING PATTERNS; EQUINE ENCEPHALOMYELITIS VIRUS; AEDES-AEGYPTI DIPTERA; IXODES-RICINUS TICKS; CHAIN-REACTION PCR; CYTOCHROME-B GENE; HETERODUPLEX ANALYSIS; MOSQUITO BLOODMEALS; MITOCHONDRIAL-DNA AB DNA-based methods have greatly enhanced the sensitivity and specificity of hematophagous arthropod bloodmeal identification. A variety of methods have been applied to study the blood-feeding behaviour of mosquitoes, ticks, black flies and other blood-feeding arthropods as it relates to host-parasite interactions and pathogen transmission. Overviews of the molecular techniques used for bloodmeal identification, their advantages, disadvantages and applications are presented for DNA sequencing, group-specific polymerase chain reaction primers, restriction fragment length polymorphism, real-time polymerase chain reaction, heteroduplex analysis, reverse line-blot hybridization and DNA profiling. Technical challenges to bloodmeal identification including digestion and analysis of mixed bloodmeals are discussed. Analysis of bloodmeal identification results remains a challenge to the field, particularly with regard to incorporation of vertebrate census and ecology data. Future research directions for molecular analysis of arthropod bloodmeals are proposed. C1 Ctr Dis Control & Prevent, Arbovirus Dis Branch, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA. RP Kent, RJ (reprint author), Ctr Dis Control & Prevent, Arbovirus Dis Branch, Div Vector Borne Infect Dis, 3150 Rampart Rd, Ft Collins, CO 80521 USA. EM fxk7@cdc.gov RI Kading, Rebekah/E-5633-2017 OI Kading, Rebekah/0000-0002-4996-915X FU American Society for Microbiology post-doctoral fellowship; Centers for Disease Control and Prevention; Robert E. Shope International Fellowship in Infectious Diseases FX Thanks are due to Dr Nicholas Komar of the Centers for Disease Control and Prevention for supporting my recent research on mosquito blood-feeding behaviour. R.J.K. is currently supported by an American Society for Microbiology post-doctoral fellowship, the Centers for Disease Control and Prevention and The Robert E. Shope International Fellowship in Infectious Diseases. NR 111 TC 83 Z9 85 U1 6 U2 56 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1755-098X EI 1755-0998 J9 MOL ECOL RESOUR JI Mol. Ecol. Resour. PD JAN PY 2009 VL 9 IS 1 BP 4 EP 18 DI 10.1111/j.1755-0998.2008.02469.x PG 15 WC Biochemistry & Molecular Biology; Ecology; Evolutionary Biology SC Biochemistry & Molecular Biology; Environmental Sciences & Ecology; Evolutionary Biology GA 397RD UT WOS:000262678900001 PM 21564560 ER PT S AU Driscoll, JR AF Driscoll, Jeffrey R. BE Caugant, DA TI Spoligotyping for Molecular Epidemiology of the Mycobacterium tuberculosis Complex SO MOLECULAR EPIDEMIOLOGY OF MICROORGANISMS SE Methods in Molecular Biology LA English DT Article; Book Chapter DE Epidemiology; genotyping; mycobacteria; spoligotyping; tuberculosis ID STRAIN; DIFFERENTIATION; RECOMMENDATIONS; IMPROVEMENT; POPULATION; BACTERIA AB Spacer oligonucleotide typing, or spoligotyping, is a rapid, polymerase chain reaction (PCR)-based method for genotyping strains of the Mycobacterium tuberculosis complex (MTB). Spoligotyping data can be represented in absolute terms (digitally), and the results can be readily shared among laboratories, thereby enabling the creation of large international databases. Since the spoligotype assay was standardized more than 10 yr ago, tens of thousands of isolates have been analyzed, giving a global picture of MTB strain diversity The method is highly reproducible and has been developed into a high-throughput assay for large molecular epidemiology projects. In the United States, spoligotyping is employed oil nearly all newly identified culture-positive cases of tuberculosis as part of a national genotyping program. The strengths of this method include its low cost, its digital data results, the good correlation of its results with other genetics markers, its fair level of overall differentiation of strains, its high-throughput capacity, and its ability to provide species information. However, the method's weaknesses include the inability of spoligotyping to differentiate well within large strain families such as the Beijing family, the potential for convergent evolution of patterns, the limited success in improving the assay through expansion, and the difficulty in obtaining the specialized membranes and instrumentation. C1 Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA. RP Driscoll, JR (reprint author), Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA. NR 26 TC 35 Z9 37 U1 1 U2 8 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 1064-3745 BN 978-1-60327-998-7 J9 METHODS MOL BIOL JI Methods Mol. Biol. PY 2009 VL 551 BP 117 EP 128 DI 10.1007/978-1-60327-999-4_10 D2 10.1007/978-1-60327-999-4 PG 12 WC Biochemical Research Methods SC Biochemistry & Molecular Biology GA BKJ96 UT WOS:000268335900010 PM 19521871 ER PT J AU Sorensen, B Jones, JF Vernon, SD Rajeevan, MS AF Sorensen, Bristol Jones, James F. Vernon, Suzanne D. Rajeevan, Mangalathu S. TI Transcriptional Control of Complement Activation in an Exercise Model of Chronic Fatigue Syndrome SO MOLECULAR MEDICINE LA English DT Article ID RHEUMATOID-ARTHRITIS; PHYSICAL-EXERCISE; GENE-EXPRESSION; MESSENGER-RNA; MONOCYTES; PCR; PROTEIN; CELLS; C1Q; C4 AB Complement activation resulting in significant increases of C4a split product may be a marker of postexertional malaise in individuals with chronic fatigue syndrome (CFS). This study focused on identification of the transcriptional control that may contribute to the increased C4a in CFS subjects after exercise. We used quantitative reverse-transcription polymerase chain reaction to evaluate differential expression of genes in the classical and lectin pathways in peripheral blood mononuclear cells (PBMCs). Calibrated expression values were normalized to the internal reference gene peptidylpropyl isomerase B (PPIB), the external reference gene ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit (rbcL), or the geometric mean (GM) of the genes ribosomal protein, large, PO(RPLPO) and phosphoglycerate kinase 1 (PGK1). All nine genes tested, except mannose-binding lectin 2 (MBL2), were expressed in PBMCs. At 1 hour postexercise, C4, mannan-binding lectin serine protease 2 (MASP2) and ficolin 1 (FCN1) transcripts were detected at higher levels (>= 2-fold) in at least 50% (4 of 8) of CFS subjects and were detected in 88% (7 of 8) CFS subjects when subjects with overexpression of either C4 or MASP2 were combined. Only an increase in the MASP2 transcript was statistically significant (PPIB, P = 0.001; GM, P = 0.047; rbcL, P = 0.045). This result may be due to the significant but transient downregulation of MASP2 in control subjects (PP/B, P = 0.023; rbcL, P = 0.027). By 6 hours postexercise, MASP2 expression was similar in both groups. In conclusion, lectin pathway responded to exercise differentially in CFS than in control subjects. MASP2 downregulation may act as an antiinflammatory acute-phase response in healthy subjects, whereas its elevated level may account for increased C4a and inflammation-mediated postexertional malaise in CFS subjects. (C) 2009 The Feinstein Institute for Medical Research, www.feinsteininstitute.org C1 [Sorensen, Bristol; Jones, James F.; Vernon, Suzanne D.; Rajeevan, Mangalathu S.] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30333 USA. RP Rajeevan, MS (reprint author), Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, 1600 Clifton Rd,MSG 41, Atlanta, GA 30333 USA. EM mor4@cdc.gov FU Centers for Disease Control and Prevention (CDC); U.S. Department of Energy; National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Division of Viral and Rickettsial Diseases FX Support for B Sorensen was provided by the research participation program at the Centers for Disease Control and Prevention (CDC), National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Division of Viral and Rickettsial Diseases, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the CDC. The authors wish to acknowledge the laboratory support of 1 Dimulescu, bioinformatics support of V Falkenberg, and the valuable comments and critical reading of the manuscript by ER Unger. NR 56 TC 19 Z9 19 U1 2 U2 4 PU FEINSTEIN INST MED RES PI MANHASSET PA 350 COMMUNITY DR, MANHASSET, NY 11030 USA SN 1076-1551 J9 MOL MED JI Mol. Med. PD JAN-FEB PY 2009 VL 15 IS 1-2 BP 34 EP 42 DI 10.2119/molmed.2008.00098 PG 9 WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental Medicine GA 604FI UT WOS:000278262300005 PM 19015737 ER PT J AU Munoz-Cadavid, CO Rudd, SK Gomez, BL AF Munoz-Cadavid, C. O. Rudd, S. K. Gomez, B. L. TI Improving molecular detection of fungal DNA in FFPE tissues: comparison of five tissue DNA extraction methods using panfungal PCR SO MYCOSES LA English DT Meeting Abstract C1 [Munoz-Cadavid, C. O.; Rudd, S. K.; Gomez, B. L.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0933-7407 J9 MYCOSES JI Mycoses PY 2009 VL 52 BP 20 EP 20 PG 1 WC Dermatology; Mycology SC Dermatology; Mycology GA 514UU UT WOS:000271422000056 ER PT S AU Elder, A Lynch, I Grieger, K Chan-Remillard, S Gatti, A Gnewuch, H Kenawy, E Korenstein, R Kuhlbusch, T Linker, F Matias, S Monteiro-Riviere, N Pinto, VRS Rudnitsky, R Savolainen, K Shvedova, A AF Elder, A. Lynch, I. Grieger, K. Chan-Remillard, S. Gatti, A. Gnewuch, H. Kenawy, E. Korenstein, R. Kuhlbusch, T. Linker, F. Matias, S. Monteiro-Riviere, N. Pinto, V. R. S. Rudnitsky, R. Savolainen, K. Shvedova, A. BE Linkov, I Steevens, J TI HUMAN HEALTH RISKS OF ENGINEERED NANOMATERIALS Critical Knowledge Gaps in Nanomaterials Risk Assessment SO NANOMATERIALS: RISKS AND BENEFITS SE NATO Science for Peace and Security Series C-Environmental Security LA English DT Proceedings Paper CT NATO Advanced Research Workshop on Nanomaterials - Environmental Risk and Benefits CY APR 27-30, 2008 CL Faro, PORTUGAL SP NATO ID WALLED-CARBON-NANOTUBES; INSOLUBLE IRIDIUM PARTICLES; QUANTUM-DOT NANOPARTICLES; IN-VITRO; COPOLYMER NANOPARTICLES; PHYSICOCHEMICAL PROPERTIES; EPIDERMAL-KERATINOCYTES; ULTRAFINE PARTICLES; OCCUPATIONAL-HEALTH; TITANIUM-DIOXIDE AB There are currently hundreds of available consumer products that contain nanoscale materials. Human exposure is, therefore, likely to occur in occupational and environmental settings. Mounting evidence suggests that some nanomaterials exert toxicity in cultured cells or following in vivo exposures, but this is dependent on the physicochemical characteristics of the materials and the dose. This Working Group report summarizes the discussions of an expert scientific panel regarding the gaps in knowledge that impede effective human health risk assessment for nanomaterials, particularly those that are suspended in a gas or liquid and, thus, deposit on skin or in the respiratory tract. In addition to extensive descriptions of material properties, the Group identified critical research areas: external and internal dose characterization, mechanisms of response, identification of sensitive subpopulations, and the development of screening strategies and technology to support these investigations. Important concepts in defining health risk are reviewed, as are the specific kinds of studies that will quickly reduce the uncertainties in the risk assessment process.(1) C1 [Elder, A.] Univ Rochester, Dept Environm Med, 575 Elmwood Ave,Box 850, Rochester, NY 14642 USA. [Lynch, I.] Univ Coll Dublin, Sch Chem & Chem Biol, Ctr BioNanoInteract, Dublin 2, Ireland. [Grieger, K.] Tech Univ Denmark, Dept Environm Engn, DK-2800 Lyngby, Denmark. [Chan-Remillard, S.] Golder Assoc Ltd HydroQual Lab Ltd, Calgary T2H 2K1, AB, Canada. [Gatti, A.] Univ Modena & Reggio Emilia, Biomat Lab, I-41100 Modena, Italy. [Gnewuch, H.] Naneum Ltd, Canterbury Enterprise Hub, Canterbury CT2 7NJ, Kent, England. [Kenawy, E.] Tanta Univ, Fac Sci, Dept Chem, Polymer Res Grp, Tanta, Egypt. [Korenstein, R.] Tel Aviv Univ, Marian Gertner Inst Med Nanosyst, Fac Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel. [Kuhlbusch, T.] Inst Energy & Environm Technol, D-47229 Duisburg, Germany. [Linker, F.] Alert & Case Ctr, ARBODienst DSM, Occupat Hlth Care Serv, NL-6167 AE Geleen, Netherlands. [Matias, S.] Univ Tecn Lisboa, Inst Super Tecn, P-1049001 Lisbon, Portugal. [Monteiro-Riviere, N.] North Carolina State Univ, Coll Vet Med, Ctr Chem Toxicol Res & Pharmacokinet, Dept Clin Sci, Raleigh, NC 27606 USA. [Rudnitsky, R.] US Dept State OES SAT, Off Space & Adv Technol, Washington, DC 20006 USA. [Savolainen, K.] New Technol & Risks Topeliuksenkatu 41 aA, Finnish Inst Occupat Hlth, GI-00250 Helsinki, Finland. [Shvedova, A.] CDC, NIOSH, Morgantown, WV 26505 USA. RP Elder, A (reprint author), Univ Rochester, Dept Environm Med, 575 Elmwood Ave,Box 850, Rochester, NY 14642 USA. EM Alison_Elder@urmc.rochester.edu RI Kuhlbusch, Thomas/G-8920-2011; Lynch, Iseult/I-3915-2014 OI Lynch, Iseult/0000-0003-4250-4584 NR 115 TC 12 Z9 13 U1 0 U2 9 PU SPRINGER PI DORDRECHT PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 1871-4668 BN 978-1-4020-9489-7 J9 NATO SCI PEACE SECUR JI NATO Sci. Peace Secur. Ser. C- Environ. Secur. PY 2009 BP 3 EP + DI 10.1007/978-1-4020-9491-0_1 PG 11 WC Environmental Sciences; Nanoscience & Nanotechnology SC Environmental Sciences & Ecology; Science & Technology - Other Topics GA BIV12 UT WOS:000262985800001 ER PT B AU Methner, M Hodson, L Geraci, C AF Methner, M. Hodson, L. Geraci, C. BE Laudon, M Romanowicz, B TI Evaluating nanoparticle emissions in the workplace: A description of the approach used by NIOSH and a summary of findings from 12 site visits SO NANOTECH CONFERENCE & EXPO 2009, VOL 2, TECHNICAL PROCEEDINGS LA English DT Proceedings Paper CT Nanotech 2009 Conference CY MAY 03-07, 2009 CL Houston, TX SP Acctron AG, Adv Energy Consortium, Alliance NanoHealth, Appl Mat, Bayer MaterialScience, Buchanan Ingersoll & Rooney PC, Buhler PARTEC GmbH, Ctr Appl Nanotechnol GmbH, Ctr Biol & Environm Nanotechnol, Clean Technol & Sustainable Ind Org, CMP, CTC Nanotechnol GmbH, DREEBIT GmbH, ETH Zurich, ETH Transfer, ETH Zurich, MNSP, Folcy & Lardner LLP, FDA, Goodwin Procter LLC, HiNanoAnalytics, Houston Technol Ctr, Inno X GmbH, Innovat Alliance Carbon Nanotubes, Italian Tradde Commiss, Jackson Walket LLP, JENOPTIK, Lockheed Martin, Nano Sci & Technol Inst, nano tech 2009 Japan, NanoEurope Fair & Conf, Nanograde Llc, NanoInk, NANOSENSORS, NanoSPRINT, NanoWorld AG, NCI, NIH, Opportun Houston, OSEC, Pearland Econ Dev Corp, Res Germany Land Ideas, Richard Smalley Inst Nanoscale Sci & Technol, Taylor & Francis Grp LLC, CRC Press, TechConnect, Texas Nanotechnol Initiat, IEEE Stand Assoc, Russian Corp Nanotechnologies, TurboBeads Llc, Weidmann Plast Technol AG DE emission assessment; measurement; identification AB NIOSH created a field team to assess potential workplace exposures to engineered nanoparticles. After exploratory field research efforts aimed at characterizing potential emissions and worker exposure using complex, not easily portable instrumentation, the field team subsequently developed a portable procedure that could be adopted by other health and safety professionals interested in determining potential releases of engineered nanoparticles from various processes. The nanoparticle emission assessment technique (NEAT) used by the NIOSH field team includes portable, direct-reading instrumentation (condensation and optical particle counters) supplemented by filter-based air samples (source-specific and personal breathing zone [PBZ]). This technique was used at 12 facilities to assess workplace emissions and potential worker exposures. C1 [Methner, M.; Hodson, L.; Geraci, C.] NIOSH, Cincinnati, OH 45226 USA. RP Methner, M (reprint author), NIOSH, 4676 Columbia Pkwy, Cincinnati, OH 45226 USA. EM mmethner@cdc.gov; lhodson@cdc.gov; cgeraci@cdc.gov NR 4 TC 0 Z9 0 U1 0 U2 1 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-1783-4 PY 2009 BP 352 EP 355 PG 4 WC Biotechnology & Applied Microbiology; Engineering, Biomedical; Nanoscience & Nanotechnology SC Biotechnology & Applied Microbiology; Engineering; Science & Technology - Other Topics GA BMQ02 UT WOS:000273330500095 ER PT J AU Villaran, MV Montano, SM Gonzalvez, G Moyano, LM Chero, JC Rodriguez, S Gonzalez, AE Pan, W Tsang, VCW Gilman, RH Garcia, HH AF Villaran, Manuel V. Montano, Silvia M. Gonzalvez, Guillermo Moyano, Luz M. Chero, Juan C. Rodriguez, Silvia Gonzalez, Armando E. Pan, William Tsang, Victor C. W. Gilman, Robert H. Garcia, Hector H. CA Cysticercosis Working Grp Peru TI Epilepsy and Neurocysticercosis: An Incidence Study in a Peruvian Rural Population SO NEUROEPIDEMIOLOGY LA English DT Article DE Epilepsy; Parasitic infection; Neurocysticercosis; Incidence study ID TAENIA-SOLIUM INFECTION; DEVELOPING-COUNTRIES; HIGH PREVALENCE; CYSTICERCOSIS; SEIZURES; EPIDEMIOLOGY; CLASSIFICATION; DIAGNOSIS; CT; MANAGEMENT AB Background: Epilepsy is a serious neurological disorder and neurocysticercosis (NCC), the central nervous system infection by the larvae of Taenia solium, is the main cause of acquired epilepsy in developing countries. NCC is becoming more frequent in industrialized countries due to immigration from endemic areas. Previously reported epilepsy incidences range from 30 to 50/100,000 people in industrialized countries and 90 to 122/100,000 people in developing countries. Objectives: To determine the incidence of epilepsy in a cysticercosis endemic area of Peru. Methods: A screening survey for possible seizure cases was repeated biannually in this cohort for a period of 5 years (1999-2004) using a previously validated questionnaire. All positive respondents throughout the study were examined by a trained neurologist in the field to confirm the seizure. If confirmed, they were offered treatment, serological testing, neuroimaging (CT scans and MRI) and clinical follow-up. Results: The cohort study comprised 817 individuals. The overall epilepsy incidence rate was 162.3/100,000 person-years, and for epileptic seizures, 216.6/100,000 person-years. Out of the 8 individuals who had epileptic seizures, 4 had markers for NCC (neuroimaging and/or serology). Conclusion: The incidence of epilepsy in this area endemic for cysticercosis is one of the highest reported worldwide. Copyright (C) 2009 S. Karger AG, Basel C1 [Garcia, Hector H.] Univ Nacl Mayor San Marcos, Cysticercosis Unit, SMP, Inst Ciencias Neurol, Lima 31, Peru. [Villaran, Manuel V.; Gilman, Robert H.; Garcia, Hector H.] Univ Peruana Cayetano Heredia, Dept Microbiol, Sch Sci, Lima, Peru. [Gonzalvez, Guillermo; Moyano, Luz M.; Chero, Juan C.] Univ Peruana Cayetano Heredia, Lima, Peru. [Villaran, Manuel V.; Montano, Silvia M.] Univ Nacl Mayor San Marcos, US Naval Med Res Ctr Detachment, Lima 31, Peru. [Gonzalez, Armando E.] Univ Nacl Mayor San Marcos, Sch Vet Med, Lima 31, Peru. [Gonzalez, Armando E.; Pan, William; Gilman, Robert H.; Garcia, Hector H.] Johns Hopkins Univ, Dept Int Hlth, Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Tsang, Victor C. W.] Ctr Dis Control, Immunol Branch, Div Parasit Dis, Natl Ctr Infect Dis, Atlanta, GA 30333 USA. RP Garcia, HH (reprint author), Univ Nacl Mayor San Marcos, Cysticercosis Unit, SMP, Inst Ciencias Neurol, Av H Delgado 430, Lima 31, Peru. EM hgarcia@jhsph.edu FU National Institute of Allergy and Infectious Diseases, NIH, USA [P01 AI51976, U01 AI35894, D43 TW001140]; Wellcome Trust; Bill and Melinda Gates Foundation; National Institute of Neurological Diseases and Stroke; Fogarty Center, NIH, USA FX This study was partially funded by research grants numbers P01 AI51976, U01 AI35894 and D43 TW001140 from the National Institute of Allergy and Infectious Diseases, NIH, USA. Research grants from the Wellcome Trust, the Bill and Melinda Gates Foundation, the National Institute of Neurological Diseases and Stroke, and the Fogarty Center, NIH, USA, support other research by the authors. NR 33 TC 15 Z9 15 U1 0 U2 4 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0251-5350 J9 NEUROEPIDEMIOLOGY JI Neuroepidemiology PY 2009 VL 33 IS 1 BP 25 EP 31 DI 10.1159/000210019 PG 7 WC Public, Environmental & Occupational Health; Clinical Neurology SC Public, Environmental & Occupational Health; Neurosciences & Neurology GA 442SS UT WOS:000265861500005 PM 19325247 ER PT J AU Caraballo, RS Novak, SP Asman, K AF Caraballo, Ralph S. Novak, Scott P. Asman, Katherine TI Linking quantity and frequency profiles of cigarette smoking to the presence of nicotine dependence symptoms among adolescent smokers: Findings from the 2004 National Youth Tobacco Survey SO NICOTINE & TOBACCO RESEARCH LA English DT Article ID MULTIDIMENSIONAL MEASURE; SCALE AB Identifying trajectories of cigarette smoking based on usage patterns is important in elucidating the pathway from initiation to nicotine dependence. Various methods have been used to identify different smoking patterns based on either quantity or frequency smoked. This paper examines the link between smoking exposure and nicotine dependence symptoms while looking at both daily and less-than-daily smokers in a nationally representative sample. Our study found a distinct pattern of cigarette smoking among adolescents aged 12-18 years, suggesting a trajectory in which smokers typically progressed through the following steps: smoking less than 1 cigarette on 1-5 days per month; smoking 1-5 cigarettes on 1-5, 6-9, 10-19, 20-29, and 30 days; and then smoking 6-10 cigarettes on 30 days, 11-20 on 30 days, and more than 20 on 30 days. Few smokers deviated from this pattern. A dose-response relationship was observed between this smoking pattern and having any of the four nicotine dependence symptoms and also with the number of reported nicotine dependence symptoms. The relationship we found between smoking exposure and nicotine dependence symptoms is consistent with the homeostasis-sensitization theory: according to which sensitization involves periods in which a person is increasing the number of cigarettes smoked per day and homeostasis occurs when the number of cigarettes smoked per day remains stable. We provide data that can be used in future studies to update and expand the work on trajectories. C1 [Caraballo, Ralph S.] Ctr Dis Control & Prevent, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Novak, Scott P.] RTI Int, Res Triangle Pk, NC USA. [Asman, Katherine] RTI Int, MSPH, Atlanta, GA USA. RP Caraballo, RS (reprint author), Ctr Dis Control & Prevent, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway,NE Mail Stop K 50, Atlanta, GA 30341 USA. EM rfc8@cdc.gov NR 31 TC 27 Z9 27 U1 0 U2 6 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1462-2203 J9 NICOTINE TOB RES JI Nicotine Tob. Res. PD JAN PY 2009 VL 11 IS 1 BP 49 EP 57 DI 10.1093/ntr/ntn008 PG 9 WC Substance Abuse; Public, Environmental & Occupational Health SC Substance Abuse; Public, Environmental & Occupational Health GA 418ZM UT WOS:000264188900007 PM 19246441 ER PT J AU Paramsothy, P Jamieson, DJ Heilig, CM Schuman, PC Klein, RS Shah, KV Rompalo, AM Cu-Uvin, S Duerr, A AF Paramsothy, Pangaja Jamieson, Denise J. Heilig, Charles M. Schuman, Paula C. Klein, Robert S. Shah, Keerti V. Rompalo, Anne M. Cu-Uvin, Susan Duerr, Ann TI The Effect of Highly Active Antiretroviral Therapy on Human Papillomavirus Clearance and Cervical Cytology SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; SQUAMOUS INTRAEPITHELIAL LESIONS; HIV-INFECTED WOMEN; POSITIVE WOMEN; SEROPOSITIVE WOMEN; NEOPLASIA; RISK; PREVALENCE; REGRESSION; COHORT AB OBJECTIVE: To examine the association of highly active antiretroviral therapy (HAART) with human papillomavirus (HPV) clearance and progression or regression of cervical cytological abnormalities in women with human immunodeficiency virus (HIV). METHODS: Five hundred thirty-seven women with HIV participating in the HIV Epidemiology Research Study, an observational, multisite cohort study, were evaluated semiannually from 1996 to 2000. Cervical Pap tests were collected for cervical cytology. Testing for HPV was conducted by polymerase chain reaction. Cox proportional hazard models were used to calculate hazard ratios and 95% confidence intervals (CIs). Number needed to treat (NNT) at 2 years was calculated for HAART. RESULTS: Among women with cervical squamous intra-epithelial lesions, HAART was associated with an increased likelihood of HPV clearance (hazard ratio 4.5, 95% CI 1.2-16.3, NNT 22.4). Use of HAART was not associated with an increased likelihood of HPV clearance among women with normal cervical cytology (hazard ratio 1.7, 95% CI 0.9-3.1, NNT 6.5) or atypical squamous cells of undetermined significance cytology (hazard ratio 1.0, 95% CI 0.4-2.5, NNT 174.0). Use of HAART was not significantly associated with an increased likelihood of cervical cytologic regression (hazard ratio 1.3, 95% CI 1.0-1.7, NNT 10.9) or cervical cytologic progression (hazard ratio 0.7, 95% CI 0.6-1.0, NNT 12.8). CONCLUSION: Among women with preexisting abnormal cervical cytology, HAART was associated with enhanced HPV clearance but not with Pap test regression. Close monitoring of women with HIV for cervical cytologic abnormalities, regardless of HAART treatment status, is warranted. C1 [Paramsothy, Pangaja] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. CONRAD, Arlington, VA USA. Wayne State Univ, Sch Med, Detroit, MI USA. Mt Sinai Sch Med, New York, NY USA. Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. Johns Hopkins Univ, Sch Med, Baltimore, MD USA. Brown Med Sch, Providence, RI USA. Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. RP Paramsothy, P (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway,Mailstop K-34, Atlanta, GA 30341 USA. EM pparaimothy@cdc.gov RI Heilig, Charles/C-2753-2008 OI Heilig, Charles/0000-0003-1075-1310 FU Centers for Disease Control and Prevention [U64/CCU106795, U64/CCU206798, U64/CCU306802, U64/CCU506831] FX Supported by the Centers for Disease Control and Prevention (cooperative agreements U64/CCU106795, U64/CCU206798, U64/CCU306802, and U64/CCU506831). NR 20 TC 48 Z9 48 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD JAN PY 2009 VL 113 IS 1 BP 26 EP 31 PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 388KG UT WOS:000262018100006 PM 19104356 ER PT J AU Kahn, EB Berg, C Callaghan, WM AF Kahn, Emily B. Berg, Cynthia J. Callaghan, William M. TI Cesarean Delivery Among Women With Low-Risk Pregnancies A Comparison of Birth Certificates and Hospital Discharge Data SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID NEW-JERSEY; STATE; RELIABILITY; VALIDATION; RECORDS; TRENDS; BRAZIL AB OBJECTIVE: To examine the effect of data source (birth certificate compared with hospital discharge records) and the definition of risk on the prevalence of cesarean deliveries thought to have "no indicated risk"; eg, the fetus is full-term, singleton, and in the vertex position, and the mother has no reported medical risk factors or complications of labor and/or delivery identified on the birth certificate. METHODS: The study is based on data from 565,767 women who delivered singleton, vertex neonates with gestational ages of 37-41 weeks in Georgia hospitals between 1999 and 2004 and for whom data from birth certificates and hospital discharge records could be linked. The percentages of women with primary cesarean deliveries who did not have risk indicated on the birth certificate and on the hospital discharge record were compared. We also calculated the agreement between data sources overall and for each risk indicator. RESULTS: Among 40,932 women with primary cesarean deliveries and no risk indicated on the birth certificate, 35,761 (87.4%) had a risk identified in the hospital discharge data. The overall agreement between data sources on the presence of any risk indicator was low (kappa=0.18). Among primary cesarean deliveries, the percentage without indicated risk was 58.3% when using birth certificate data alone and 3.9% when using hospital discharge data in combination with the birth certificate. CONCLUSION: Using birth certificate information alone overestimated the proportion of women who had no-indicated-risk cesarean deliveries in Georgia. Evidence of many indications for cesarean delivery can be found only in the hospital discharge data. The construct of no indicated risk as determined from birth certificates should be interpreted with caution, and the use of linked data should be considered whenever possible. C1 [Kahn, Emily B.] Ctr Dis Control & Prevent, Mat & Infant Hlth Branch, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Kahn, EB (reprint author), Ctr Dis Control & Prevent, Mat & Infant Hlth Branch, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Mailstop K-23,4770 Buford Highway, Atlanta, GA 30341 USA. EM ebk9@cdc.gov OI Kahn, Emily/0000-0001-7812-7958 NR 23 TC 24 Z9 24 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD JAN PY 2009 VL 113 IS 1 BP 33 EP 40 PG 8 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 388KG UT WOS:000262018100007 PM 19104357 ER PT J AU Yong, LC Sigurdson, AJ Ward, EM Waters, MA Whelan, EA Petersen, MR Bhatti, P Ramsey, MJ Ron, E Tucker, JD AF Yong, L. C. Sigurdson, A. J. Ward, E. M. Waters, M. A. Whelan, E. A. Petersen, M. R. Bhatti, P. Ramsey, M. J. Ron, E. Tucker, J. D. TI Increased frequency of chromosome translocations in airline pilots with long-term flying experience SO OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID COSMIC-RADIATION EXPOSURE; AIR CREW MEMBERS; IONIZING-RADIATION; CANCER-RISK; ABERRATION ANALYSIS; LYMPHOCYTES; WORKERS; DAMAGE; FISH; BIODOSIMETRY AB Background: Chromosome translocations are an established biomarker of cumulative exposure to external ionising radiation. Airline pilots are exposed to cosmic ionising radiation, but few flight crew studies have examined translocations in relation to flight experience. Methods: We determined the frequency of translocations in the peripheral blood lymphocytes of 83 airline pilots and 50 comparison subjects (mean age 47 and 46 years, respectively). Translocations were scored in an average of 1039 cell equivalents (CE) per subject using fluorescence in situ hybridisation (FISH) whole chromosome painting and expressed per 100 CE. Negative binomial regression models were used to assess the relationship between translocation frequency and exposure status and flight years, adjusting for age, diagnostic x ray procedures, and military flying. Results: There was no significant difference in the adjusted mean translocation frequency of pilots and comparison subjects (0.37 (SE 0.04) vs 0.38 (SE 0.06) translocations/100 CE, respectively). However, among pilots, the adjusted translocation frequency was significantly associated with flight years (p = 0.01) with rate ratios of 1.06 (95% CI 1.01 to 1.11) and 1.81 (95% CI 1.16 to 2.82) for a 1- and 10-year incremental increase in flight years, respectively. The adjusted rate ratio for pilots in the highest compared to the lowest quartile of flight years was 2.59 (95% CI 1.26 to 5.33). Conclusions: Our data suggests that pilots with long-term flying experience may be exposed to biologically significant doses of ionising radiation. Epidemiological studies with longer follow-up of larger cohorts of pilots with a wide range of radiation exposure levels are needed to clarify the relationship between cosmic radiation exposure and cancer risk. C1 [Yong, L. C.; Waters, M. A.; Whelan, E. A.; Petersen, M. R.] NIOSH, Industrywide Studies Branch, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH 45226 USA. [Sigurdson, A. J.; Bhatti, P.; Ron, E.] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Ward, E. M.] Amer Canc Soc, Dept Epidemiol & Surveillance Res, Atlanta, GA 30329 USA. [Ramsey, M. J.] Lawrence Livermore Natl Lab, Livermore, CA USA. [Tucker, J. D.] Wayne State Univ, Dept Biol Sci, Detroit, MI 48202 USA. RP Yong, LC (reprint author), NIOSH, Industrywide Studies Branch, Div Surveillance Hazard Evaluat & Field Studies, 4676 Columbia Pkwy,R-15, Cincinnati, OH 45226 USA. EM LAY7@CDC.GOV RI Waters, Martha/B-7441-2011 FU National Institute for Occupational Safety and Health and the National Cancer Institute [Y1CP802904]; Intramural Research Program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute FX This research was supported in part by an interagency agreement between the National Institute for Occupational Safety and Health and the National Cancer Institute contract Y1CP802904 and by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute. Work was performed in part under the auspices of the U. S. DOE by the Lawrence Livermore National Laboratory under contract no. W-7405-ENG-48. NR 40 TC 27 Z9 28 U1 2 U2 13 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1351-0711 J9 OCCUP ENVIRON MED JI Occup. Environ. Med. PD JAN PY 2009 VL 66 IS 1 BP 56 EP 62 DI 10.1136/oem.2008.038901 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 385SH UT WOS:000261833400011 PM 19074211 ER PT J AU Miller, EA Manning, SE Rasmussen, SA Reefhuis, J Honein, MA AF Miller, Eric A. Manning, Susan E. Rasmussen, Sonja A. Reefhuis, Jennita Honein, Margaret A. CA Natl Birth Defects Prevention TI Maternal exposure to tobacco smoke, alcohol and caffeine, and risk of anorectal atresia: National Birth Defects Prevention Study 1997-2003 SO PAEDIATRIC AND PERINATAL EPIDEMIOLOGY LA English DT Article DE maternal caffeine; maternal alcohol; maternal smoking; maternal ETS; imperforate anus; congenital malformations ID CONGENITAL-ANOMALIES; ANAL ATRESIA; PREGNANCY; MALFORMATIONS; CONSUMPTION; OUTCOMES; HEALTH; COFFEE; MOUSE AB Anorectal atresia is a congenital anomaly with mostly unknown risk factors. Studies have provided evidence of teratogenic effects of alcohol and tobacco, and animal studies have suggested that caffeine may potentiate their teratogenicity. However, it is unclear how these factors affect the risk of anorectal atresia. We analysed data from maternal telephone interviews in a multistate case-control study with 464 infants with anorectal atresia and 4940 infants with no major birth defects. We used unconditional logistic regression to determine the association of exposure to smoking, environmental tobacco smoke (ETS), alcohol or caffeine with anorectal atresia. Effect modification by caffeine intake was assessed on additive and multiplicative scales. There was no association with alcohol intake in this analysis. However, there was some evidence of an association between anorectal atresia and maternal exposure to tobacco smoke and caffeine. Compared with non-smokers not exposed to ETS, the crude odds ratio (OR) and 95% confidence interval [CI] for cigarette smoking was 1.2 [95% CI 1.0, 1.5]. The association with anorectal atresia for non-smokers exposed to ETS at home and work was OR = 2.3 [95% CI 1.2, 4.1]. Compared with the lowest level of caffeine intake (< 10 mg/day), the association for the highest caffeine intake (>= 300 mg/day) was OR = 1.5 [95% CI 1.0, 2.2]. Results did not change after adjustment for covariates. This study found evidence of associations between anorectal atresia and caffeine intake, cigarette smoking and exposure to ETS. Because there are currently few additional data to support these results, further study is needed. C1 [Miller, Eric A.; Rasmussen, Sonja A.; Reefhuis, Jennita; Honein, Margaret A.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Manning, Susan E.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Manning, Susan E.] Massachusetts Dept Publ Hlth, Boston, MA USA. RP Miller, EA (reprint author), Texas Dept State Hlth Serv, 1100 W 49th St,M-342, Austin, TX 78756 USA. EM eric.miller@dshs.state.tx.us RI Reefhuis, Jennita/E-1793-2011; Publications, NBDPS/B-7692-2013 OI Reefhuis, Jennita/0000-0002-4747-4831; FU Centers for Disease Control and Prevention FX Supported by the Centers for Disease Control and Prevention. NR 33 TC 23 Z9 26 U1 2 U2 6 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0269-5022 J9 PAEDIATR PERINAT EP JI Paediatr. Perinat. Epidemiol. PD JAN PY 2009 VL 23 IS 1 BP 9 EP 17 DI 10.1111/j.1365-3016.2008.00976.x PG 9 WC Public, Environmental & Occupational Health; Obstetrics & Gynecology; Pediatrics SC Public, Environmental & Occupational Health; Obstetrics & Gynecology; Pediatrics GA 377TH UT WOS:000261273000003 PM 19228309 ER PT J AU Siega-Riz, AM Herring, AH Olshan, AF Smith, J Moore, C AF Siega-Riz, Anna Maria Herring, Amy H. Olshan, Andrew F. Smith, Joanna Moore, Cynthia CA Natl Birth Defects Prevention TI The joint effects of maternal prepregnancy body mass index and age on the risk of gastroschisis SO PAEDIATRIC AND PERINATAL EPIDEMIOLOGY LA English DT Article DE prepregnancy weight; BMI; maternal age; gastroschisis; congenital abnormalities ID BIRTH-DEFECTS PREVENTION; OMPHALOCELE; PREVALENCE; OBESITY; WEIGHT; PATHOGENESIS; ASSOCIATION; OVERWEIGHT; PREGNANCY; EXPOSURES AB Young maternal age has been associated with an increased risk of gastroschisis, while high maternal weight status has been associated with a decreased risk. We were interested in investigating the joint effect of these two risk factors to identify thresholds in risk associated with body mass index (BMI) for a given age. Data from the National Birth Defects Prevention Study included 464 case infants with gastroschisis and 4842 healthy controls. A generalised additive model with a bivariate spline for continuous maternal age and prepregnancy BMI was used to model the probability of gastroschisis. The bivariate spline in BMI and maternal age was significantly associated with gastroschisis (P = 0.0001) after adjustment for study centre, maternal race/ethnicity, education, income and number of persons supported by income, smoking, alcohol use, vitamin use, vasoconstrictor medication use and gestational diabetes. The data indicate that women who are younger and who have lower BMI are at the greatest risk; a woman with a BMI of 17 who gives birth at age 15 has 7 times the odds (adjusted odds ratio = 7.0 [95% CI 4.2, 11.5]) of having an offspring with gastroschisis compared with a woman of age 24 with a BMI of 23. Furthermore, there was an interaction between maternal age and BMI for this risk. The increased risk of low maternal age and prepregnancy BMI associated with gastroschisis appears to suggest an aetiological role related to biological immaturity for this particular birth defect. C1 [Siega-Riz, Anna Maria] Univ N Carolina, Carolina Populat Ctr, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27516 USA. [Siega-Riz, Anna Maria] Univ N Carolina, Sch Publ Hlth, Dept Nutr, Chapel Hill, NC 27516 USA. [Herring, Amy H.] Univ N Carolina, Sch Publ Hlth, Dept Biostat, Chapel Hill, NC 27516 USA. [Moore, Cynthia] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Siega-Riz, AM (reprint author), Univ N Carolina, Carolina Populat Ctr, Sch Publ Hlth, Dept Epidemiol, CB 8120 Univ Square, Chapel Hill, NC 27516 USA. EM am_siegariz@unc.edu RI Publications, NBDPS/B-7692-2013 FU Centers for Disease Control [U50/CCU422096]; National Institute of Environmental Health Sciences [P30ES10126] FX Research Support: Supported in part by grants from the Centers for Disease Control (U50/CCU422096) and National Institute of Environmental Health Sciences (P30ES10126).; The findings and conclusions in this article are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 30 TC 33 Z9 33 U1 0 U2 5 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0269-5022 J9 PAEDIATR PERINAT EP JI Paediatr. Perinat. Epidemiol. PD JAN PY 2009 VL 23 IS 1 BP 51 EP 57 DI 10.1111/j.1365-3016.2008.00990.x PG 7 WC Public, Environmental & Occupational Health; Obstetrics & Gynecology; Pediatrics SC Public, Environmental & Occupational Health; Obstetrics & Gynecology; Pediatrics GA 377TH UT WOS:000261273000008 PM 19228314 ER PT J AU Peacock, G Allsopp, MY AF Peacock, Georgina Allsopp, Marshalyn Yeargin TI Autism Spectrum Disorders: Prevalence and Vaccines SO PEDIATRIC ANNALS LA English DT Article ID RUBELLA VACCINATION; MMR VACCINATION; MEASLES; CHILDREN; MUMPS; IMMUNIZATION; MERCURY C1 [Peacock, Georgina; Allsopp, Marshalyn Yeargin] Ctr Dis Control, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Peacock, G (reprint author), Ctr Dis Control, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS E-86, Atlanta, GA 30333 USA. EM gpeacock@cdc.gov NR 27 TC 1 Z9 1 U1 2 U2 22 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0090-4481 J9 PEDIATR ANN JI Pediatr. Annu. PD JAN PY 2009 VL 38 IS 1 BP 22 EP 25 PG 4 WC Pediatrics SC Pediatrics GA 394ZI UT WOS:000262491300005 PM 19213289 ER PT J AU Cordovado, SK Earley, M Hendrix, M Farrell, P Greene, C Hannon, WH Mueller, P AF Cordovado, S. K. Earley, M. Hendrix, M. Farrell, P. Greene, C. Hannon, W. H. Mueller, P. TI MOLECULAR CHARACTERIZATION OF CFTR IN CF SPECIMENS USED FOR NEWBORN SCREENING PROFICIENCY TESTING SO PEDIATRIC PULMONOLOGY LA English DT Meeting Abstract C1 [Cordovado, S. K.; Earley, M.; Hendrix, M.; Greene, C.; Hannon, W. H.; Mueller, P.] Ctr Dis Control & Prevent, Newborn Screening & Mol Biol Branch, Atlanta, GA USA. [Farrell, P.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Populat Hlth Sci, Madison, WI USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 8755-6863 J9 PEDIATR PULM JI Pediatr. Pulmonol. PY 2009 MA 169 BP 270 EP 270 PG 1 WC Pediatrics; Respiratory System SC Pediatrics; Respiratory System GA 505OL UT WOS:000270703400248 ER PT J AU Earley, MC Li, L Driscoll-Dunn, R Mei, JV Hannon, WH AF Earley, M. C. Li, L. Driscoll-Dunn, R. Mei, J., V Hannon, W. H. TI PROFICIENCY TESTING FOR CYSTIC FIBROSIS NEWBORN SCREENING WORLDWIDE SO PEDIATRIC PULMONOLOGY LA English DT Meeting Abstract C1 [Earley, M. C.; Li, L.; Driscoll-Dunn, R.; Mei, J., V; Hannon, W. H.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 8755-6863 J9 PEDIATR PULM JI Pediatr. Pulmonol. PY 2009 MA 474 BP 380 EP 380 PG 1 WC Pediatrics; Respiratory System SC Pediatrics; Respiratory System GA 505OL UT WOS:000270703400553 ER PT J AU Grosse, SD Schechter, MS Kulkarni, R Lloyd-Puryear, MA Strickland, B Trevathan, E AF Grosse, Scott D. Schechter, Michael S. Kulkarni, Roshni Lloyd-Puryear, Michele A. Strickland, Bonnie Trevathan, Edwin TI Models of Comprehensive Multidisciplinary Care for Individuals in the United States With Genetic Disorders SO PEDIATRICS LA English DT Article DE genetic services; care coordination; health care disparities; health care utilization ID SICKLE-CELL-DISEASE; HEALTH-CARE; CYSTIC-FIBROSIS; MEDICAL HOME; HEMOPHILIA-CARE; CHILDREN; SERVICES; PEOPLE; MALES; NEEDS AB Approaches to providing comprehensive coordinated care for individuals with complex diseases include the medical home approach, the chronic care model in primary care, and disease-specific, multidisciplinary specialty clinics. There is uneven availability and utilization of multidisciplinary specialty clinics for different genetic diseases. For 2 disorders (ie, hemophilia and cystic fibrosis), effective national networks of specialty clinics exist and reach large proportions of the target populations. For other disorders, notably, sickle cell disease, fewer such centers are available, centers are less likely to be networked, and centers are used less widely. Models of comanagement are essential for promoting ongoing communication and coordination between primary care and subspecialty services, particularly during the transition from pediatric care to adult care. Evaluation of the effectiveness of different models in improving outcomes for individuals with genetic diseases is essential. Pediatrics 2009;123:407-412 C1 [Trevathan, Edwin] CDC, Natl Ctr Birth Defects & Dev Disabil, Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Schechter, Michael S.] Emory Univ, Dept Pediat, Atlanta, GA 30322 USA. [Lloyd-Puryear, Michele A.; Strickland, Bonnie] US Hlth Resources & Serv Adm, Maternal & Child Hlth Bur, Rockville, MD 20857 USA. RP Trevathan, E (reprint author), CDC, Natl Ctr Birth Defects & Dev Disabil, Ctr Dis Control & Prevent, Mail Stop E-87,1600 Clifton Rd, Atlanta, GA 30333 USA. EM net1@cdc.gov NR 50 TC 71 Z9 73 U1 3 U2 12 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD JAN PY 2009 VL 123 IS 1 BP 407 EP 412 DI 10.1542/peds.2007-2875 PG 6 WC Pediatrics SC Pediatrics GA 388UZ UT WOS:000262046400059 PM 19117908 ER PT J AU Lieu, TA Ray, GT Ortega-Sanchez, IR Kleinman, K Rusinak, D Prosser, LA AF Lieu, Tracy A. Ray, G. Thomas Ortega-Sanchez, Ismael R. Kleinman, Ken Rusinak, Donna Prosser, Lisa A. TI Willingness to Pay for a QALY Based on Community Member and Patient Preferences for Temporary Health States Associated with Herpes Zoster SO PHARMACOECONOMICS LA English DT Article ID ADJUSTED LIFE-YEAR; POSTHERPETIC NEURALGIA; COST-EFFECTIVENESS; OLDER-ADULTS; VACCINE; SENSITIVITY; ISSUES AB Background and Objectives: A clear sense of what society is willing to pay for a QALY could enhance the usefulness of cost-effectiveness analysis as a field. Scant information exists on willingness to pay (WTP) for a QALY based oil direct elicitation of preferences from community members or patients. We had the opportunity to evaluate WTP per QALY using data from a survey on temporary health outcomes related to herpes zoster. Our aims were to (i) describe how much Community members are willing to pay to save a QALY based on scenarios describing temporary health states; (ii) evaluate how WTP per QALY varies based on experience with the disease being described and with demographic variables; and (iii) evaluate how the duration and intensity of pain in a scenario influences WTP per QALY. Methods: Community members drawn from a nationally representative survey research panel (n = 478) completed an Internet-based survey using time trade-off (TTO) and WTP questions to value a series of scenarios that described herpes zoster cases of varying pain intensity (on a scale of 0-10) and duration (30 days to I year). Patients with shingles (n = 354) or postherpetic neuralgia (PHN; n = 120) [defined as having symptoms for 90 days or more] from two large healthcare systems completed telephone interviews with similar questions. Mean and median WTP per QALY values were calculated by dividing the WTP amount by the discounted time traded for each scenario. Responses with a WTP value of more than zero and a TTO Value of zero (which would have resulted in an undefined value) were excluded. TTO values were discounted by 3% per year. WTP per QALY means were calculated after trimming the top and bottom 2.5% of responses. Multivariate analyses were conducted using generalized linear mixed models that assumed a negative binomial distribution. Results: Among all respondents, the WTP per QALY ranged from a median of $US7000 to $US11000 and a trimmed mean of $US26 000 to $US45 000 (year 2005 values), depending on the scenario described. WTP per QALY values varied significantly with respondent characteristics, as well as among respondents with similar characteristics. In multivariate analyses, the mean WTP per QALY was higher among respondents who were younger, male or had higher educational or income levels. After adjusting for these demographic variables, patients who had experienced shingles gave responses with the highest WTP per QALY values. Patients who had experienced PHN gave the lowest values, and community members gave values intermediate to the shingles and PHN groups. In multivariate models that evaluated the effects of pain and duration of the hypothetical zoster scenario, lower duration was associated with higher WTP per QALY. This effect appeared to be due to people increasing the amounts of time they would be willing to trade as duration increased, without proportional increases in the amounts of money they would be willing to pay. Conclusions: Community members and patients gave mean WTP per QALY values that varied significantly based on age, sex, socioeconomic status, experience with shingles and duration of the health state evaluated. The variability in WTP per QALY suggests that it may be difficult to define a unitary threshold of dollars per QALY for policy making based on cost-effectiveness analyses. C1 [Lieu, Tracy A.; Kleinman, Ken; Rusinak, Donna; Prosser, Lisa A.] Harvard Pilgrim Hlth Care, Dept Ambulatory Care & Prevent, Boston, MA 02215 USA. [Lieu, Tracy A.; Kleinman, Ken; Rusinak, Donna; Prosser, Lisa A.] Harvard Univ, Sch Med, Boston, MA USA. [Lieu, Tracy A.] Childrens Hosp, Div Gen Pediat, Boston, MA 02115 USA. [Ray, G. Thomas] Kaiser Permanente, Div Res, Oakland, CA USA. [Ortega-Sanchez, Ismael R.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Lieu, TA (reprint author), Harvard Pilgrim Hlth Care, Dept Ambulatory Care & Prevent, 133 Brookline Ave,6th Floor, Boston, MA 02215 USA. EM tracy_lieu@harvardpilgrim.org FU Centers for Disease Control and Prevention (CDC) [U01IP000029, U01 IP000143]; Wyeth; Merck FX The findings and conclusions expressed are those of the authors and do not necessarily represent tire views of the CDC or Department of Health and Human Services. G. Thomas Ray has received research funding from Wyeth for an unrelated study and from Merck for a study related to the epidemiology of herpes zoster. All other authors have no conflicts of interest that are directly relevant to the content of this study. NR 34 TC 14 Z9 14 U1 1 U2 7 PU ADIS INT LTD PI AUCKLAND PA 41 CENTORIAN DR, PRIVATE BAG 65901, MAIRANGI BAY, AUCKLAND 1311, NEW ZEALAND SN 1170-7690 J9 PHARMACOECONOMICS JI Pharmacoeconomics PY 2009 VL 27 IS 12 BP 1005 EP 1016 PG 12 WC Economics; Health Care Sciences & Services; Health Policy & Services; Pharmacology & Pharmacy SC Business & Economics; Health Care Sciences & Services; Pharmacology & Pharmacy GA 539QN UT WOS:000273272400004 PM 19908925 ER PT J AU Bhalla, K Harrison, J Abraham, J Borse, NN Lyons, R Boufous, S Aharonson-Daniel, L AF Bhalla, Kavi Harrison, James Abraham, Jerry Borse, Nagesh N. Lyons, Ronan Boufous, Soufiane Aharonson-Daniel, Limor CA Global Burden Dis Injury Expert Gr TI Data Sources for Improving Estimates of the Global Burden of Injuries: Call for Contributors SO PLOS MEDICINE LA English DT Editorial Material C1 [Bhalla, Kavi; Abraham, Jerry] Harvard Univ, Harvard Initiat Global Hlth, Cambridge, MA 02138 USA. [Harrison, James] Flinders Univ S Australia, Res Ctr Injury Studies, Adelaide, SA, Australia. [Borse, Nagesh N.] Ctr Dis Control & Prevent, Off Workforce & Career Dev, Atlanta, GA USA. [Borse, Nagesh N.] Ctr Dis Control & Prevent, Home & Recreat Team, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA. [Lyons, Ronan] Swansea Univ, Ctr Hlth Informat, Swansea, W Glam, Wales. [Boufous, Soufiane] Univ Sydney, Injury Div, George Inst Int Hlth, Sydney, NSW 2006, Australia. [Boufous, Soufiane] Univ Sydney, Sch Publ Hlth, Sydney, NSW 2006, Australia. [Aharonson-Daniel, Limor] Ben Gurion Univ Negev, Dept Emergency Med, IL-84105 Beer Sheva, Israel. RP Bhalla, K (reprint author), Harvard Univ, Harvard Initiat Global Hlth, Cambridge, MA 02138 USA. EM kavi_bhalla@harvard.edu RI Borse, Nagesh/A-9276-2009; Harrison, James/B-8958-2009; AHARONSON-DANIEL, LIMOR/F-1998-2012; Lyons, Ronan/G-7741-2012 OI Harrison, James/0000-0001-9893-8491; AHARONSON-DANIEL, LIMOR/0000-0003-4585-6892; Lyons, Ronan/0000-0001-5225-000X NR 3 TC 18 Z9 19 U1 0 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1549-1277 J9 PLOS MED JI PLos Med. PD JAN PY 2009 VL 6 IS 1 BP 22 EP 24 AR e1000001 DI 10.1371/journal.pmed.1000001 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 399PF UT WOS:000262811100008 PM 19166263 ER PT J AU Lescano, AG Garcia, HH Gilman, RH Gavidia, CM Tsang, VCW Rodriguez, S Moulton, LH Villaran, MV Montano, SM Gonzalez, AE AF Lescano, Andres G. Garcia, Hector H. Gilman, Robert H. Gavidia, Cesar M. Tsang, Victor C. W. Rodriguez, Silvia Moulton, Lawrence H. Villaran, Manuel V. Montano, Silvia M. Gonzalez, Armando E. CA Cysticercosis Working Grp Peru TI Taenia solium Cysticercosis Hotspots Surrounding Tapeworm Carriers: Clustering on Human Seroprevalence but Not on Seizures SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID LINKED IMMUNOELECTROTRANSFER BLOT; EPILEPTIC SEIZURES; FILTER-PAPER; WHOLE-BLOOD; FIELD TRIAL; NEUROCYSTICERCOSIS; INFECTION; ELISA; PERU; POPULATIONS AB Background: Neurocysticercosis accounts for 30%-50% of all late-onset epilepsy in endemic countries. We assessed the clustering patterns of Taenia solium human cysticercosis seropositivity and seizures around tapeworm carriers in seven rural communities in Peru. Methodology: The presence of T. solium-specific antibodies was defined as one or more positive bands in the enzyme-linked immunoelectrotransfer blot (EITB). Neurocysticercosis-related seizures cases were diagnosed clinically and had positive neuroimaging or EITB. Principal Findings: Eleven tapeworm carriers were identified by stool microscopy. The seroprevalence of human cysticercosis was 24% (196/803). Seroprevalence was 21%>50 m from a carrier and increased to 32% at 1-50 m (p = 0.047), and from that distance seroprevalence had another significant increase to 64% at the homes of carriers (p = 0.004). Seizure prevalence was 3.0% (25/837) but there were no differences between any pair of distance ranges (p = 0.629, Wald test 2 degrees of freedom). Conclusion/Significance: We observed a significant human cysticercosis seroprevalence gradient surrounding current tapeworm carriers, although cysticercosis-related seizures did not cluster around carriers. Due to differences in the timing of the two outcomes, seroprevalence may reflect recent T. solium exposure more accurately than seizure frequency. C1 [Lescano, Andres G.; Montano, Silvia M.] US Naval Med Res Ctr Detachment, Publ Hlth Training Program AGL, Lima, Peru. [Lescano, Andres G.; Montano, Silvia M.] Virol Program SMM, Lima, Peru. [Lescano, Andres G.; Garcia, Hector H.; Gilman, Robert H.; Gavidia, Cesar M.; Moulton, Lawrence H.; Gonzalez, Armando E.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA. [Lescano, Andres G.; Garcia, Hector H.; Gilman, Robert H.; Montano, Silvia M.] Univ Peruana Cayetano Heredia, Sch Publ Hlth & Adm AGL & SMM, Lima, Peru. [Lescano, Andres G.; Garcia, Hector H.; Gilman, Robert H.; Montano, Silvia M.] Univ Peruana Cayetano Heredia, Sch Sci, Dept Microbiol, HHG,RHG, Lima, Peru. [Gilman, Robert H.] Asoc Benef PRISMA Proyectos Informat Salud Med &, Res Dept, Lima, Peru. [Gavidia, Cesar M.; Gonzalez, Armando E.] Univ Nacl Mayor San Marcos, Sch Vet Med, Lima 14, Peru. [Tsang, Victor C. W.] US Ctr Dis Control & Prevent, Atlanta, GA USA. RP Lescano, AG (reprint author), US Naval Med Res Ctr Detachment, Publ Hlth Training Program AGL, Lima, Peru. EM hgarcia@jhsph.edu RI Lescano, Andres/B-8479-2008; OI Lescano, Andres/0000-0001-9779-633X; Moulton, Lawrence/0000-0001-7041-7387; Gavidia, Cesar Miguel/0000-0003-3936-5077 FU National Institute of Allergy and Infectious Diseases, NIH, USA [P01 AI51976, U01 AI35894]; Wellcome Trust [063109]; Food and Drug Administration [002309]; Bill & Melinda Gates Foundation [23981] FX This study was partially funded by research grant numbers P01 AI51976 and U01 AI35894 from the National Institute of Allergy and Infectious Diseases, NIH, USA. Research grants from the Wellcome Trust ( 063109), the Food and Drug Administration ( 002309) and the Bill & Melinda Gates Foundation ( 23981) fund ongoing cysticercosis research by the authors. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 35 TC 42 Z9 42 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD JAN PY 2009 VL 3 IS 1 AR e371 DI 10.1371/journal.pntd.0000371 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 406NB UT WOS:000263301100019 PM 19172178 ER PT J AU van Eijk, AM Lindblade, KA Odhiambo, F Peterson, E Rosen, DH Karanja, D Ayisi, JG Shi, YP Adazu, K Slutsker, L AF van Eijk, Anna M. Lindblade, Kim A. Odhiambo, Frank Peterson, Elizabeth Rosen, Daniel H. Karanja, Diana Ayisi, John G. Shi, Ya Ping Adazu, Kubaje Slutsker, Laurence TI Geohelminth Infections among Pregnant Women in Rural Western Kenya; a Cross-Sectional Study SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID ASCARIS-LUMBRICOIDES INFECTION; HELMINTH INFECTIONS; ANTHELMINTIC TREATMENT; MALARIA TRANSMISSION; CYTOKINE RESPONSES; CEREBRAL MALARIA; ANEMIA; PLASMODIUM; EPIDEMIOLOGY; PREVALENCE AB Background: Geohelminth infections are common in rural western Kenya, but risk factors and effects among pregnant women are not clear. Methodology: During a community-based cross-sectional survey, pregnant women were interviewed and asked to provide a blood sample and a single fecal sample. Hemoglobin was measured and a blood slide examined for malaria. Geohelminth infections were identified using the concentration and Kato-Katz method. Results: Among 390 participants who provided a stool sample, 76.2% were infected with at least one geohelminth: 52.3% with Ascaris lumbricoides, 39.5% with hookworm, and 29.0% with Trichuris trichiura. Infection with at least one geohelminth species was associated with the use of an unprotected water source (adjusted odds ratio [AOR] 1.8, 95% confidence interval [CI] 1.1-3.0) and the lack of treatment of drinking water (AOR 1.8, 95% CI 1.1-3.1). Geohelminth infections were not associated with clinical symptoms, or low body mass index. A hookworm infection was associated with a lower mid upper arm circumference (adjusted mean decrease 0.7 cm, 95% CI 0.3-1.2 cm). Hookworm infections with an egg count >= 1000/gram feces (11 women) were associated with lower hemoglobin (adjusted mean decrease 1.5 g/dl, 95% CI 0.3-2.7). Among gravidae 2 and 3, women with A. lumbricoides were less likely to have malaria parasitemia (OR 0.4, 95% CI 0.2-0.8) compared to women without A. lumbricoides, unlike other gravidity groups. Conclusion: Geohelminth infections are common in this pregnant population; however, there were few observed detrimental effects. Routine provision of antihelminth treatment during an antenatal clinic visit is recommended, but in this area an evaluation of the impact on pregnancy, malaria, and birth outcome is useful. C1 [van Eijk, Anna M.] Univ Amsterdam, Acad Med Ctr, Dept Infect Dis Trop Med & AIDS, NL-1105 AZ Amsterdam, Netherlands. [Lindblade, Kim A.; Shi, Ya Ping; Slutsker, Laurence] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA USA. [Odhiambo, Frank; Karanja, Diana; Ayisi, John G.; Adazu, Kubaje] Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Kisumu, Kenya. [Peterson, Elizabeth] Vermont Dept Hlth, Burlington, VT 05402 USA. [Rosen, Daniel H.] Ctr Dis Control & Prevent, Global AIDS Program, Harare, Zimbabwe. RP van Eijk, AM (reprint author), Univ Amsterdam, Acad Med Ctr, Dept Infect Dis Trop Med & AIDS, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands. EM amvaneijk@gmail.com FU CDC FX This study was funded by CDC. The funders had no role in study design, data collection and analysis, or preparation of the manuscript. The funder was in favor of publication of the manuscript. NR 51 TC 19 Z9 19 U1 0 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD JAN PY 2009 VL 3 IS 1 AR e370 DI 10.1371/journal.pntd.0000370 PG 9 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 406NB UT WOS:000263301100018 PM 19172184 ER PT J AU Botosso, VF Zanotto, PMDA Ueda, M Arruda, E Gilio, AE Vieira, SE Stewien, KE Peret, TCT Jamal, LF Pardini, MIDMC Pinho, JRR Massad, E Sant'Anna, OA Holmes, EC Durigon, EL AF Botosso, Viviane F. Zanotto, Paolo M. de A. Ueda, Mirthes Arruda, Eurico Gilio, Alfredo E. Vieira, Sandra E. Stewien, Klaus E. Peret, Teresa C. T. Jamal, Leda F. Pardini, Maria I. de M. C. Pinho, Joao R. R. Massad, Eduardo Sant'Anna, Osvaldo A. Holmes, Eddie C. Durigon, Edison L. CA VGDN Consortium TI Positive Selection Results in Frequent Reversible Amino Acid Replacements in the G Protein Gene of Human Respiratory Syncytial Virus SO PLOS PATHOGENS LA English DT Article ID ATTACHMENT G-GLYCOPROTEIN; CARBOHYDRATE SIDE-CHAINS; SUBGROUP-A; MOLECULAR EPIDEMIOLOGY; GROUP-B; CIRCULATION PATTERNS; SOUTH-AFRICA; MONOCLONAL-ANTIBODIES; EVOLUTIONARY PATTERN; CONSECUTIVE SEASONS AB Human respiratory syncytial virus (HRSV) is the major cause of lower respiratory tract infections in children under 5 years of age and the elderly, causing annual disease outbreaks during the fall and winter. Multiple lineages of the HRSVA and HRSVB serotypes co-circulate within a single outbreak and display a strongly temporal pattern of genetic variation, with a replacement of dominant genotypes occurring during consecutive years. In the present study we utilized phylogenetic methods to detect and map sites subject to adaptive evolution in the G protein of HRSVA and HRSVB. A total of 29 and 23 amino acid sites were found to be putatively positively selected in HRSVA and HRSVB, respectively. Several of these sites defined genotypes and lineages within genotypes in both groups, and correlated well with epitopes previously described in group A. Remarkably, 18 of these positively selected tended to revert in time to a previous codon state, producing a "flipflop'' phylogenetic pattern. Such frequent evolutionary reversals in HRSV are indicative of a combination of frequent positive selection, reflecting the changing immune status of the human population, and a limited repertoire of functionally viable amino acids at specific amino acid sites. C1 [Botosso, Viviane F.; Sant'Anna, Osvaldo A.] Butantan Inst, Virol Branch, Sao Paulo, Brazil. [Zanotto, Paolo M. de A.; Stewien, Klaus E.] Univ Sao Paulo, Dept Microbiol, Inst Biomed Sci, Lab Mol Evolut & Bioinformat, Sao Paulo, Brazil. [Ueda, Mirthes] Adolfo Lutz Inst, Div Med Biol, Sao Paulo, Brazil. [Arruda, Eurico] Univ Sao Paulo, Dept Cell Biol, Fac Med Ribeirao Preto, Sao Paulo, Brazil. [Gilio, Alfredo E.; Vieira, Sandra E.] Univ Sao Paulo, Univ Hosp, Div Pediat, Sao Paulo, Brazil. [Peret, Teresa C. T.] Ctr Dis Control & Prevent, Coordinating Ctr Infect Dis, Natl Ctr Immunizat & Resp Dis, Gastroenteritis & Resp Viruses Lab Branch,Div Vir, Atlanta, GA USA. [Jamal, Leda F.] STD AIDS Reference & Training Ctr, Sao Paulo, Brazil. [Pardini, Maria I. de M. C.] State Univ Sao Paulo, Sao Paulo, Brazil. [Pinho, Joao R. R.] Univ Sao Paulo, Inst Trop Med, Sao Paulo, Brazil. [Massad, Eduardo] Univ Sao Paulo, Sch Med, Dept Legal Med, Sao Paulo, Brazil. [Holmes, Eddie C.] Penn State Univ, Dept Biol, Ctr Infect Dis Dynam, Mueller Lab, University Pk, PA 16802 USA. [Holmes, Eddie C.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Durigon, Edison L.] Univ Sao Paulo, Dept Microbiol, Inst Biomed Sci, Lab Clin Virol, Sao Paulo, Brazil. RP Botosso, VF (reprint author), Butantan Inst, Virol Branch, Sao Paulo, Brazil. EM pzanotto@usp.br RI Gilio, Alfredo/A-8819-2010; Massad, Eduardo/H-6143-2011; Arruda, Eurico/E-4101-2012; vieira, sandra/I-9456-2012; Massad, Eduardo/B-1169-2012; Toxinas, Inct/I-1933-2013; Pinho, Joao/G-2850-2012; Proenca-Modena, Jose/C-8231-2014; Gilio, Alfredo/J-4229-2014; Botosso, Viviane/I-5591-2014; Schvartsman, Claudio/M-8706-2015; Moraes, Claudia/K-4708-2016 OI Durigon, Edison/0000-0003-4898-6553; Grisi Candeias, Joao Manuel/0000-0003-1515-702X; Holmes, Edward/0000-0001-9596-3552; vieira, sandra/0000-0001-5100-8713; Massad, Eduardo/0000-0002-7200-2916; Pinho, Joao/0000-0003-3999-0489; Botosso, Viviane/0000-0002-7876-3687; Schvartsman, Claudio/0000-0001-5695-9331; Moraes, Claudia/0000-0001-6782-4790 FU FAPESP [00/04205-6]; CNPq, Brazil FX This project was made possible by the VGDN program funded by FAPESP project #00/04205-6 and by CNPq, Brazil. NR 55 TC 62 Z9 64 U1 1 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1553-7366 J9 PLOS PATHOG JI PLoS Pathog. PD JAN PY 2009 VL 5 IS 1 AR e1000254 DI 10.1371/journal.ppat.1000254 PG 11 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA 415IP UT WOS:000263927800031 PM 19119418 ER PT J AU Myjak, P Szulta, J de Almeida, ME da Silva, AJ Steurer, F Lass, A Pietkiewicz, H Nahorski, WL Goljan, J Knap, J Szostakowska, B AF Myjak, Przemyslaw Szulta, Joanna de Almeida, Marcos E. da Silva, Alexandre J. Steurer, Francis Lass, Anna Pietkiewicz, Halina Nahorski, Waclaw L. Goljan, Jolanta Knap, Jozef Szostakowska, Beata TI Usefulness of PCR Method for Detection of Leishmania in Poland SO POLISH JOURNAL OF MICROBIOLOGY LA English DT Article DE leishmaniosis in Poland; molecular diagnosis (PCR) ID POLYMERASE-CHAIN-REACTION; CUTANEOUS LEISHMANIASIS; DIAGNOSIS AB Leishmania parasites are the etiological agents of leishmaniosis, with severe course and often fatal prognosis, and the global number of cases has increased in recent decades. The gold standards for the diagnosis of leishmaniosis are microscopic examinations and culture in vitro of the different clinical specimens. The sensitivity of these methods is insufficient. Recent development in specific and sensitive molecular methods (PCR) allows for detection as well as identification of the parasite species (subspecies). The aim of the study was to estimate the usefulness of molecular methods (PCR) for detection of Leishmania species and consequently for the implementation of such methods in routine diagnostics of leishmaniosis in Polish patients returning from endemic areas of the disease. In our investigations we used 54 known Leishmania positive DNA templates (from culture and clinical specimens) received from the CDC (Atlanta, GA, USA). Moreover, 25 samples of bone marrow, blood or other tissues obtained from 18 Polish individuals suspected of leishmaniosis were also examined. In PCR we used two pairs of primers specific to the conserved region of Leishmania kinetoplast DNA (kDNA) minicircle (13A/13B and F/R). Using these primers we obtained amplicons in all DNA templates from the CDC and in three Polish patients suspected for Leishmania infection. In one sample from among these cases we also obtained positive results with DNA isolated from a blood specimen which was previously negative in microscopic examinations. C1 [Myjak, Przemyslaw] Med Univ Gdansk, Interfac Inst Maritime & Trop Med, Dept Trop Parasitol, Chair Trop Med & Parasitol, PL-81519 Gdynia, Poland. [de Almeida, Marcos E.; da Silva, Alexandre J.; Steurer, Francis] Ctr Dis Control & Prevent, Parasit Dis Branch, Div Parasit Dis, Atlanta, GA USA. [Knap, Jozef] Inst Agr Med, Dept Environm Hyg & Parasitol, Lublin, Poland. RP Myjak, P (reprint author), Med Univ Gdansk, Interfac Inst Maritime & Trop Med, Dept Trop Parasitol, Chair Trop Med & Parasitol, Powstania Styczniowego 9B, PL-81519 Gdynia, Poland. EM pemyjak@gumed.edu.pl NR 14 TC 2 Z9 2 U1 0 U2 5 PU POLSKIE TOWARZYSTWO MIKROBIOLOGOW PI WARSAW PA UL CHOCIMSKA 24, WARSAW, 00000, POLAND SN 1733-1331 J9 POL J MICROBIOL JI Pol. J. Microbiol. PY 2009 VL 58 IS 3 BP 219 EP 222 PG 4 WC Microbiology SC Microbiology GA 499IK UT WOS:000270212300005 PM 19899614 ER PT B AU Gibbons, DE AF Gibbons, Deborah E. BE Graen, GB Graen, JA TI STRATEGIC DEVELOPMENT OF NETWORK STRUCTURES THAT SUPPORT LEARNING AND ADAPTATION SO PREDATOR'S GAME-CHANGING DESIGNS: RESEARCH-BASED TOOLS SE LMX Leadership Series LA English DT Article; Book Chapter ID INFORMATION OVERLOAD; ORGANIZATION; COMMUNICATION AB As organizations' environments become more complex and dynamic, rapid responses that are increasingly needed can become decreasingly manageable by formal leaders alone. Many businesses, nonprofit organizations, and government agencies manage everyday activities through long-standing structures and policies that are not conducive to learning and adaptation. Even in organizations that regularly review and update their formal designs, prescribed structures cannot equal the adaptive and responsive capabilities of informal ties among organization members and between members and external entities. The informal networks change and grow as information and opportunities present themselves, creating fluid and adaptive conduits for subsequent diffusion of ideas and coordination of action. In this chapter; I describe research-based strategies to help emergent leaders develop effective informal networks that benefit participating individuals and the organizations that they support. C1 [Gibbons, Deborah E.] USN, Postgrad Sch, Monterey, CA USA. [Gibbons, Deborah E.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Gibbons, Deborah E.] CDC, Atlanta, GA 30333 USA. NR 25 TC 0 Z9 0 U1 0 U2 1 PU INFORMATION AGE PUBLISHING-IAP PI CHARLOTTE PA PO BOX 79049, CHARLOTTE, NC 28271-7047 USA BN 978-1-60752-150-1 J9 LMX LEADERSH SER PY 2009 BP 19 EP 42 PG 24 WC Management SC Business & Economics GA BLI21 UT WOS:000270228800002 ER PT J AU Collins, JL Lehnherr, J Posner, SF Toomey, KE AF Collins, Janet L. Lehnherr, John Posner, Samuel F. Toomey, Kathleen E. TI Ties That Bind: Maternal and Child Health and Chronic Disease Prevention at the Centers for Disease Control and Prevention SO PREVENTING CHRONIC DISEASE LA English DT Editorial Material C1 [Collins, Janet L.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Off Director, Atlanta, GA 30341 USA. RP Collins, JL (reprint author), Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Off Director, 4770 Buford Hwy NE,MS K-40, Atlanta, GA 30341 USA. EM jlc1@cdc.gov NR 18 TC 7 Z9 7 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD JAN PY 2009 VL 6 IS 1 AR A01 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA V20RU UT WOS:000208157900001 PM 19080007 ER PT J AU Dilorio, C Escoffery, C Yeager, KA McCarty, F Henry, TR Koganti, A Reisinger, E Robinson, E Kobau, R Price, P AF Dilorio, Colleen Escoffery, Cam Yeager, Katherine A. McCarty, Frances Henry, Thomas R. Koganti, Archana Reisinger, Elizabeth Robinson, Elise Kobau, Rosemarie Price, Patricia TI WebEase: Development of a Web-Based Epilepsy Self-Management Intervention SO PREVENTING CHRONIC DISEASE LA English DT Article AB People with epilepsy must adopt many self-management behaviors, especially regarding medication adherence, stress management, and sleep quality. In response to the need for theory-based self-management programs that people with epilepsy can easily access, the WebEase Web site was created and tested for feasibility, acceptability, and usability. This article discusses the theoretical background and developmental phases of WebEase and lessons learned throughout the development process. The WebEase research team developed content for the Web site on the basis of social cognitive theory, the transtheoretical model of behavior change, and motivational interviewing. Formative research and development of the WebEase program included a literature search, computer use survey, a focus group, and review by content experts and consumers. The program has 2 main components: 1) the modules, which provide a tailored opportunity for learning, reflection, and goal setting, and 2) MyLog, a place to enter daily information. C1 [Dilorio, Colleen] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Koganti, Archana] Grady Mem Hosp, Atlanta, GA USA. [McCarty, Frances] Georgia State Univ, Atlanta, GA 30303 USA. [Henry, Thomas R.] Univ Minnesota, Minneapolis, MN USA. [Robinson, Elise] Harvard Univ, Boston, MA 02115 USA. [Kobau, Rosemarie; Price, Patricia] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Dilorio, C (reprint author), Emory Univ, Rollins Sch Publ Hlth, 1518 Clifton Rd,5th Floor, Atlanta, GA 30322 USA. EM cdiiori@sph.emory.edu FU Centers for Disease Control and Prevention [U48 DP000043, 2-05] FX This study was supported by a grant from the Centers for Disease Control and Prevention cooperative agreement no. U48 DP000043, Special Interest Project 2-05. Special thanks to Padraic McGovern and Edward Jahns for their programming services. We also thank our consumer panel, study participants, recruiters at the clinic, and the following members of the content expert panel: Joan K. Austin, Janice Buelow, Mimi Callanan, and Patricia Osborne Shafer. NR 39 TC 14 Z9 15 U1 0 U2 5 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD JAN PY 2009 VL 6 IS 1 AR A28 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA V20RU UT WOS:000208157900028 ER PT J AU Fan, AZ Strine, TW Huang, YJ Murray, MR Musingo, S Jiles, R Mokdad, AH AF Fan, Amy Z. Strine, Tara W. Huang, Youjie Murray, Melissa R. Musingo, Senyoni Jiles, Ruth Mokdad, Ali H. TI Self-Rated Depression and Physician-Diagnosed Depression and Anxiety in Florida Adults: Behavioral Risk Factor Surveillance System, 2006 SO PREVENTING CHRONIC DISEASE LA English DT Article AB Introduction Our purpose was to determine the prevalence and correlates of self-reported symptoms of depression and physician-diagnosed depression and anxiety in Florida adults by using the 2006 Florida Behavioral Risk Factor Surveillance System (BRFSS). Methods The BRFSS is an ongoing, state-based telephone health survey of noninstitutionalized adults that uses random-digit dialing. In 2006, an Anxiety and Depression Module was administered in Florida. Eight questions were used to examine current depression. Two additional questions assessed health care provider diagnosis of depressive and anxiety disorders. We used SUDAAN version 9.0 to evaluate the data to accommodate the complex sampling design. Results Approximately 9% of Florida adults experienced current depression; about 13% had had a diagnosis of depression in their lifetime and 11% had a diagnosis of anxiety in their lifetime. Approximately 44% of respondents with current depression had not had a diagnosis of depression. Current depression and lifetime diagnosis of depression and anxiety were independently associated with sociodemographic variables (being a woman, young, previously married or never married, or unemployed or unable to work), adverse health behaviors (current or former smoking, physical inactivity, or obesity), and chronic health conditions (history of a stroke, diabetes, or asthma). Although the prevalence of depression among non-Hispanic blacks and people with low education levels is higher, members of these groups are less likely than members of other sociodemographic groups to have had depression diagnosed by a physician. Conclusion Depression and anxiety are associated with sociodemographic disadvantages and chronic conditions and risk factors. Knowing the prevalence of depression and anxiety, both self-rated and physician-diagnosed, is useful in identifying unmet mental health needs among subpopulations. C1 [Fan, Amy Z.; Strine, Tara W.; Jiles, Ruth; Mokdad, Ali H.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Huang, Youjie; Murray, Melissa R.] Florida Dept Hlth, Tallahassee, FL USA. [Musingo, Senyoni] Dept Children & Families, Tallahassee, FL USA. RP Fan, AZ (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway NE,Mailstop K-66, Atlanta, GA 30341 USA. EM afan@cdc.gov NR 29 TC 9 Z9 10 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD JAN PY 2009 VL 6 IS 1 AR A10 PG 14 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA V20RU UT WOS:000208157900010 PM 19080016 ER PT J AU Kruger, J Ham, SA Prohaska, TR AF Kruger, Judy Ham, Sandra A. Prohaska, Thomas R. TI Behavioral Risk Factors Associated With Overweight and Obesity Among Older Adults: the 2005 National Health Interview Survey SO PREVENTING CHRONIC DISEASE LA English DT Article AB Introduction Obesity is associated with coronary heart disease, stroke, certain cancers, hypertension, and type 2 diabetes. Concern about obesity among older adults is growing, and research to examine behaviors associated with risk for increased weight in this population is needed. We examined differences by sex in behaviors associated with overweight and obesity among older adults (aged >= 50 years). Methods We analyzed data from the 2005 National Health Interview Survey using logistic regression to predict the likelihood of overweight (body mass index [BMI], 25.0-29.9 kg/m(2)) and obesity (BMI >= 30.0 kg/m(2)) relative to healthy weight (BMI, 18.5-24.9 kg/m(2)) among older adults. We used self-reported weights and heights. Correlates were risk behaviors for chronic disease (smoking status, alcohol intake, consumption of fruits and vegetables, leisure-time physical activity, walking for leisure, walking for transportation, and strength training). Results Among older men, the prevalence of overweight was 46.3%, and the prevalence of obesity was 25.1%. Among older women, the prevalence of overweight was 33.4%, and the prevalence of obesity was 28.8%. In adjusted logistic regression models, sex differences were observed in the significance of most risk factors for overweight and obesity. Men who were occasional, light, or moderate drinkers were 28% more likely to be obese than men who were nondrinkers; women who were heavy drinkers were 55% less likely to be obese than women who were nondrinkers. Compared with men and women who were regularly active during leisure time, inactive men were 39% more likely to be obese, and inactive women were 28% more likely to be obese. Conclusion Several risk behaviors for chronic disease appear to be associated with overweight and obesity among older adults. Modification of these behaviors has the potential to reduce weight. C1 [Kruger, Judy] Ctr Dis Control & Prevent, Div Nutr & Phys Act, Atlanta, GA 30341 USA. [Prohaska, Thomas R.] Univ Illinois, Chicago, IL USA. RP Kruger, J (reprint author), Ctr Dis Control & Prevent, Div Nutr & Phys Act, 4770 Buford Hwy NE,Mail Stop K-46, Atlanta, GA 30341 USA. EM ezk0@cdc.gov NR 43 TC 28 Z9 28 U1 2 U2 6 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD JAN PY 2009 VL 6 IS 1 AR A14 PG 17 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA V20RU UT WOS:000208157900014 PM 19080020 ER PT J AU Yoon, PW Scheuner, MT Jorgensen, C Khoury, MJ AF Yoon, Paula W. Scheuner, Maren T. Jorgensen, Cynthia Khoury, Muin J. TI Developing Family Healthware, a Family History Screening Tool to Prevent Common Chronic Diseases SO PREVENTING CHRONIC DISEASE LA English DT Article AB Family health history reflects the effects of genetic, environmental, and behavioral factors and is an important risk factor for a variety of disorders including coronary heart disease, cancer, and diabetes. In 2004, the Centers for Disease Control and Prevention developed Family Healthware, a new interactive, Web-based tool that assesses familial risk for 6 diseases (coronary heart disease, stroke, diabetes, and colorectal, breast, and ovarian cancer) and provides a "prevention plan" with personalized recommendations for lifestyle changes and screening. The tool collects data on health behaviors, screening tests, and disease history of a person's first-and second-degree relatives. Algorithms in the software analyze the family history data and assess familial risk based on the number of relatives affected, their age at disease onset, their sex, how closely related the relatives are to each other and to the user, and the combinations of diseases in the family. A second set of algorithms uses the data on familial risk level, health behaviors, and screening to generate personalized prevention messages. Qualitative and quantitative formative research on lay understanding of family history and genetics helped shape the tool's content, labels, and messages. Lab-based usability testing helped refine messages and tool navigation. The tool is being evaluated by 3 academic centers by using a network of primary care practices to determine whether personalized prevention messages tailored to familial risk will motivate people at risk to change their lifestyles or screening behaviors. C1 [Yoon, Paula W.; Jorgensen, Cynthia; Khoury, Muin J.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Scheuner, Maren T.] RAND Corp, Santa Monica, CA USA. RP Yoon, PW (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy NE,Mailstop K47, Atlanta, GA 30341 USA. EM pyoon@cdc.gov NR 50 TC 64 Z9 64 U1 1 U2 5 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD JAN PY 2009 VL 6 IS 1 AR A33 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA V20RU UT WOS:000208157900033 PM 19080039 ER PT J AU Brown, DW AF Brown, David W. TI The dawn of Healthy People 2020: A brief look back at its beginnings SO PREVENTIVE MEDICINE LA English DT Letter DE Healthy People programs; Historical notes C1 Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. RP Brown, DW (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway NE MS K67, Atlanta, GA 30341 USA. EM dbrown6@cdc.gov NR 5 TC 4 Z9 4 U1 1 U2 5 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0091-7435 J9 PREV MED JI Prev. Med. PD JAN PY 2009 VL 48 IS 1 BP 94 EP 95 DI 10.1016/j.ypmed.2008.10.007 PG 2 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 401DE UT WOS:000262918000017 PM 19007805 ER PT S AU Wolfe, ND Switzer, WM AF Wolfe, Nathan D. Switzer, William M. BE Huffman, MA Chapman, CA TI Primate exposure and the emergence of novel retroviruses SO PRIMATE PARASITE ECOLOGY: THE DYNAMICS AND STUDY OF HOST-PARASITE RELATIONSHIPS SE Cambridge Studies in Biological and Evolutionary Anthropology LA English DT Article; Book Chapter ID CELL LYMPHOTROPIC VIRUS; SIMIAN IMMUNODEFICIENCY VIRUS; GORILLA-GORILLA-BERINGEI; FOAMY VIRUS; NONHUMAN-PRIMATES; INTERSPECIES TRANSMISSION; CERCOCEBUS-TORQUATUS; WILD CHIMPANZEES; PAPIO-HAMADRYAS; WORLD PRIMATES C1 [Wolfe, Nathan D.] Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90095 USA. [Switzer, William M.] Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, Natl Ctr HIV Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA. RP Wolfe, ND (reprint author), Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, 650 Charles E Young Dr S,CHS 71-279B,Box 177220, Los Angeles, CA 90095 USA. NR 75 TC 4 Z9 4 U1 0 U2 2 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA THE PITT BUILDING, TRUMPINGTON ST, CAMBRIDGE CB2 1RP, CAMBS, ENGLAND SN 1746-2266 BN 978-0-521-87246-1 J9 CAM S BIO EVOL ANTHR JI CAMBR STUD BIO EVOL ANTHROPOL PY 2009 VL 57 BP 353 EP 370 PG 18 WC Ecology; Parasitology; Zoology SC Environmental Sciences & Ecology; Parasitology; Zoology GA BDP12 UT WOS:000314288200018 ER PT J AU Li, JC Snyder, DP Damiano, NW AF Li, Jingcheng Snyder, David P. Damiano, Nicholas W. GP ION TI Exploration of Two Position Adjustment Methods for Underground Mine Tracking Systems SO PROCEEDINGS OF THE 2009 INTERNATIONAL TECHNICAL MEETING OF THE INSTITUTE OF NAVIGATION - ITM 2009 LA English DT Proceedings Paper CT 2009 International Technical Meeting of the Institute-of-Navigation CY JAN 26-28, 2009 CL Anaheim, CA AB Currently many underground coal mines worldwide have installed or been planning to install a tracking system to trace miners mainly for their safety. Although many systems have been reported functional, a lack of sophisticated and systematic error correction methods apparently is still an issue for them; often it results in a low system resolution. To improve the system resolutions, this paper introduces two position adjustment methods for mine tracking systems. The first is an entry-matching method that optimally adjusts an off-course tracking device to the closest tunnel (entry). The second is a distance measurement adjustment method that accurately adjusts the position of a tracking device along an entry according to a measured distance from the device to a reference point. The coplanar node-path network mine model is used as the foundation for the development of these two methods. C1 [Li, Jingcheng; Damiano, Nicholas W.] NIOSH, Pittsburgh Res Lab, CDC, Washington, DC USA. RP Li, JC (reprint author), NIOSH, Pittsburgh Res Lab, CDC, Washington, DC USA. NR 11 TC 0 Z9 0 U1 0 U2 0 PU INST NAVIGATION PI WASHINGTON PA 815 15TH ST NW, STE 832, WASHINGTON, DC 20005 USA PY 2009 BP 814 EP 821 PG 8 WC Computer Science, Artificial Intelligence; Remote Sensing; Telecommunications SC Computer Science; Remote Sensing; Telecommunications GA BPT37 UT WOS:000279863400080 ER PT J AU Khoury, MJ Bowen, S Bradley, LA Coates, R Dowling, NF Gwinn, M Kolor, K Moore, CA St Pierre, J Valdez, R Yoon, PW AF Khoury, M. J. Bowen, S. Bradley, L. A. Coates, R. Dowling, N. F. Gwinn, M. Kolor, K. Moore, C. A. St Pierre, J. Valdez, R. Yoon, P. W. TI A Decade of Public Health Genomics in the United States: Centers for Disease Control and Prevention 1997-2007 SO PUBLIC HEALTH GENOMICS LA English DT Review DE Epidemiology; Genetics; Genomics; Public health ID COMMON DISEASES; EPIDEMIOLOGY; CONTRIBUTE; MEDICINE; NETWORK; WILL AB Since 1997, the Centers for Disease Control and Prevention (CDC) has collaborated with numerous partners to develop and chart the course of the multidisciplinary field of public health genomics in the USA and globally. During this period, CDC has developed major initiatives for the appropriate integration of genomics into public health research, policy and programs. In this paper, we review briefly the progress in public health genomics made over the past decade in the USA, including population research, the human genome epidemiology network (HuGENet (TM)), the evaluation of genomic applications in practice and prevention (EGAPP), the family history public health initiative, and efforts in building the public health genomics capacity. We also outline a vision for public health genomics for the next decade. Copyright (C) 2008 S. Karger AG, Basel C1 [Khoury, M. J.; Bowen, S.; Bradley, L. A.; Coates, R.; Dowling, N. F.; Gwinn, M.; Kolor, K.; Moore, C. A.; St Pierre, J.; Valdez, R.; Yoon, P. W.] Ctr Dis Control & Prevent, Natl Off Publ Hlth Genom, Atlanta, GA 30341 USA. RP Khoury, MJ (reprint author), Ctr Dis Control & Prevent, Natl Off Publ Hlth Genom, 4770 Buford Hwy,MS K-89, Atlanta, GA 30341 USA. EM muk1@cdc.gov NR 29 TC 11 Z9 12 U1 1 U2 3 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1662-4246 J9 PUBLIC HEALTH GENOMI JI Pub. Health Genomics PY 2009 VL 12 IS 1 BP 20 EP 29 DI 10.1159/000153427 PG 10 WC Genetics & Heredity; Public, Environmental & Occupational Health SC Genetics & Heredity; Public, Environmental & Occupational Health GA 400ZW UT WOS:000262908900004 PM 19023187 ER PT J AU Yoo, BK Grosse, SD AF Yoo, B. K. Grosse, S. D. TI The Cost Effectiveness of Screening Newborns for Congenital Adrenal Hyperplasia SO PUBLIC HEALTH GENOMICS LA English DT Article DE Congenital adrenal hyperplasia; Cost effectiveness; Newborn screening ID 21-HYDROXYLASE DEFICIENCY; DIAGNOSIS; PREVALENCE; SWEDEN; TEXAS; LIFE AB Objective: To assess the cost effectiveness of newborn screening for congenital adrenal hyperplasia (CAH) in the U.S. newborn population. Methods: We constructed a decision model to estimate the incremental cost-effectiveness ratio (ICER) of CAH screening compared to a strategy of no screening. Two types of cost effectiveness analyses (CEA) were conducted to measure ICER as net cost per life year (LY): (1) traditional CEA with sensitivity and scenario analyses, and (2) probabilistic CEA. Results: ICERs for (1) base-case analysis in traditional CEA and (2) probabilistic CEA were USD 292,000 and USD 255,700 per LY saved in 2005 USD, respectively. ICERs were particularly sensitive to assumptions regarding the mortality rate for the salt wasting type of CAH, in a range from 2 to 9%. The ICERs for best-case and worst-case scenarios were USD 30,900 and USD 2.9 million per LY saved, respectively. Conclusions: Using common benchmarks for cost effectiveness, our results indicate that CAH screening would be unlikely to be considered cost effective unless assumptions favorable to screening were adopted, although it could meet economic criteria used to assess U.S. regulatory policies. A limitation is that the analysis excludes outcomes such as correct assignment of gender and quality of life. Copyright (C) 2008 S. Karger AG, Basel C1 [Yoo, B. K.] Univ Rochester, Dept Community & Prevent Med, Sch Med & Dent, Div Hlth Serv Res & Policy, Rochester, NY 14642 USA. [Grosse, S. D.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. RP Yoo, BK (reprint author), Univ Rochester, Dept Community & Prevent Med, Sch Med & Dent, Div Hlth Serv Res & Policy, 601 Elmwood Ave,Box 644, Rochester, NY 14642 USA. EM Byung-Kwang_Yoo@urmc.rochester.edu NR 28 TC 14 Z9 15 U1 0 U2 1 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1662-4246 J9 PUBLIC HEALTH GENOMI JI Pub. Health Genomics PY 2009 VL 12 IS 2 BP 67 EP 72 DI 10.1159/000156115 PG 6 WC Genetics & Heredity; Public, Environmental & Occupational Health SC Genetics & Heredity; Public, Environmental & Occupational Health GA 402EK UT WOS:000262996800001 PM 19039250 ER PT J AU Goddard, KAB Robitaille, J Dowling, NF Parrado, AR Fishman, J Bradley, LA Moored, CA Khoury, MJ AF Goddard, K. A. B. Robitaille, J. Dowling, N. F. Parrado, A. R. Fishman, J. Bradley, L. A. Moored, C. A. Khoury, M. J. TI Health-Related Direct-to-Consumer Genetic Tests: A Public Health Assessment and Analysis of Practices Related to Internet-Based Tests for Risk of Thrombosis SO PUBLIC HEALTH GENOMICS LA English DT Article DE Direct access testing; Factor V Leiden; Nutrigenomics; Pharmacogenomics ID FACTOR-V-LEIDEN; CYSTIC-FIBROSIS DELTA-F508; ACTIVATED PROTEIN-C; VENOUS THROMBOSIS; THROMBOPHILIA; LABORATORIES AB Background: Recent years have seen increased concern about direct-to-consumer (DTC) genetic testing (i.e., the sale and use of genetic tests without involving a health care provider). Numerous professional organizations have developed policies in this area. However, little systematic evidence exists to inform public policy about these tests. Methods: We conducted a systematic search to identify genetic tests that are sold DTC without involving a health care provider. We evaluated the practices of companies offering DTC genetic tests for risk of thrombosis using criteria from multiple sources and a minimal set of key practices. Results: We identified 84 instances of currently available health-related DTC genetic tests sold on 27 Web sites; the most common were for pharmacogenomics (12), risk of thrombosis (10), and nutrigenomics (10). For the DTC genetic tests for risk of thrombosis, we found low adherence to recommendations. Online information was frequently incomplete and had low agreement with professional recommendations. Conclusion: Our findings document the rapid growth in the availability of health-related DTC genetic tests and highlight the need to improve the delivery of DTC genetic tests. A major implication of this study is the need for the scientific and medical community to develop Consistent recommendations to increase their impact. Copyright (C) 2008 S. Karger AG, Basel C1 [Goddard, K. A. B.] Kaiser Permanente NW, Ctr Hlth Res, Portland, OR 97227 USA. [Goddard, K. A. B.; Parrado, A. R.] Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA. [Goddard, K. A. B.; Dowling, N. F.; Bradley, L. A.; Khoury, M. J.] Ctr Dis Control & Prevent, Natl Off Publ Hlth Genom, Atlanta, GA USA. [Robitaille, J.; Moored, C. A.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Robitaille, J.] Univ Laval, Inst Neutraceut & Funct Foods, Quebec City, PQ, Canada. [Fishman, J.] Case Western Reserve Univ, Dept Bioeth, Cleveland, OH 44106 USA. [Fishman, J.] McGill Univ, Biomed Eth Unit, Montreal, PQ, Canada. RP Goddard, KAB (reprint author), Kaiser Permanente NW, Ctr Hlth Res, 3800 N Interstate Ave, Portland, OR 97227 USA. EM katrina.ab.goddard@kpchr.org RI Robitaille, Julie/O-4892-2016 OI Robitaille, Julie/0000-0001-7035-0477 FU Centers for Disease Control and Prevention and the American Society of Human Genetics in Public Health Genomics Research and Practice FX This work was supported, in part, by fellowships (to K.G. and J.R.) jointly sponsored by the Centers for Disease Control and Prevention and the American Society of Human Genetics in Public Health Genomics Research and Practice. We have no conflicts of interest to report. NR 34 TC 28 Z9 30 U1 1 U2 2 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1662-4246 J9 PUBLIC HEALTH GENOMI JI Pub. Health Genomics PY 2009 VL 12 IS 2 BP 92 EP 104 DI 10.1159/000176794 PG 13 WC Genetics & Heredity; Public, Environmental & Occupational Health SC Genetics & Heredity; Public, Environmental & Occupational Health GA 402EK UT WOS:000262996800004 PM 19039253 ER PT J AU Guessous, I Gwinn, M Yu, W Yeh, J Clyne, M Khoury, MJ AF Guessous, I. Gwinn, M. Yu, W. Yeh, J. Clyne, M. Khoury, M. J. TI Trends in Pharmacogenomic Epidemiology: 2001-2007 SO PUBLIC HEALTH GENOMICS LA English DT Article DE Epidemiology; Genomics; Pharmacogenomics ID ADVERSE DRUG-REACTIONS; ASSOCIATION; POLYMORPHISM; WARFARIN; PHARMACOEPIDEMIOLOGY; RECOMMENDATIONS; CYP2C9; GENE AB Background: Pharmacogenomic epidemiology (PGxE) assesses the range of responses to pharmacologic agents in relation to genetic variation in population groups. We analyzed publication trends to describe the emerging field of PGxE. Methods: We analyzed PGxE literature published from 2001 to 2007 by using the HuGE Navigator, a curated database of abstracts on human genome epidemiology extracted from PubMed. We summarized trends by gene and study design and, for the 4 most cited genes, by associated health outcomes and drugs. Results: In all, 1,855 PGxE articles were indexed from 2001 through 2007, with annual publications increasing more than 15-fold during this period. Observational studies outnumbered clinical trials by a ratio of 10 to 1 (1,660 vs. 178). Just 4 genes together accounted for nearly one-fifth of all publications: ABCB1, CYP2C9, CYP2C19, and CYP2D6. For these 4 genes, the most frequently cited therapeutic category was antineoplastic agent, followed by anticoagulant, antiulcer, and antidepressant. Warfarin was the single most frequently cited drug. Conclusions: The field of PGxE is growing rapidly, encompassing a large spectrum of diseases and drugs important in clinical practice. Systematic tracking and synthesis of the published literature in PGxE can help identify promising applications and guide translation research. Copyright (C) 2009 S. Karger AG, Basel C1 [Guessous, I.; Gwinn, M.; Yu, W.; Yeh, J.; Clyne, M.; Khoury, M. J.] CDC, Natl Off Publ Hlth Genom, Atlanta, GA 30341 USA. [Guessous, I.] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA. RP Guessous, I (reprint author), CDC, Natl Off Publ Hlth Genom, 4770 Buford Highway Mailstop K-89, Atlanta, GA 30341 USA. EM goq3@cdc.gov FU Research Participation Program at the Centers for Disease Control and Prevention; U.S. Department of Energy; CDC FX This research was supported in part by the appointment of ldris Guessous to the Research Participation Program at the Centers for Disease Control and Prevention administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the CDC. NR 47 TC 5 Z9 7 U1 0 U2 1 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1662-4246 J9 PUBLIC HEALTH GENOMI JI Pub. Health Genomics PY 2009 VL 12 IS 3 BP 142 EP 148 DI 10.1159/000189626 PG 7 WC Genetics & Heredity; Public, Environmental & Occupational Health SC Genetics & Heredity; Public, Environmental & Occupational Health GA 410NX UT WOS:000263585600003 PM 19204416 ER PT J AU Wideroff, L Phillips, KA Randhawa, G Ambs, A Armstrong, K Bennett, CL Brown, ML Donaldson, MS Follen, M Goldie, SJ Hiatt, RA Khoury, MJ Lewis, G McLeod, HL Piper, M Powell, I Schrag, D Schulman, KA Scott, J AF Wideroff, Louise Phillips, Kathryn A. Randhawa, Gurvaneet Ambs, Anita Armstrong, Katrina Bennett, Charles L. Brown, Martin L. Donaldson, Molla S. Follen, Michele Goldie, Sue J. Hiatt, Robert A. Khoury, Muin J. Lewis, Graham McLeod, Howard L. Piper, Margaret Powell, Isaac Schrag, Deborah Schulman, Kevin A. Scott, Joan TI A Health Services Research Agenda for Cellular, Molecular and Genomic Technologies in Cancer Care SO PUBLIC HEALTH GENOMICS LA English DT Review DE Genomics; Health services research; Emerging technologies; Translational research ID COST-EFFECTIVENESS ANALYSIS; METASTATIC BREAST-CANCER; REPORTS RADAR PROJECT; ADVERSE DRUG EVENTS; CLINICAL-PRACTICE; RACIAL-DIFFERENCES; CERVICAL-CANCER; PUBLIC-HEALTH; PROPHYLACTIC VACCINES; PROSTATE-CANCER AB Background: In recent decades, extensive resources have been invested to develop cellular, molecular and genomic technologies with clinical applications that span the continuum of cancer care. Methods: In December 2006, the National Cancer Institute sponsored the first workshop to uniquely examine the state of health services research on cancer-related cellular, molecular and genomic technologies and identify challenges and priorities for expanding the evidence base on their effectiveness in routine care. Results: This article summarizes the workshop outcomes, which included development of a comprehensive research agenda that incorporates health and safety endpoints, utilization patterns, patient and provider preferences, quality of care and access, disparities, economics and decision modeling, trends in cancer outcomes, and health-related quality of life among target populations. Conclusions: Ultimately, the successful adoption of useful technologies will depend on understanding and influencing the patient, provider, health care system and societal factors that contribute to their uptake and effectiveness in 'real-world' settings. Copyright (C) 2009 S. Karger AG, Basel C1 [Wideroff, Louise; Ambs, Anita; Brown, Martin L.] NCI, Bethesda, MD 20892 USA. [Phillips, Kathryn A.; Hiatt, Robert A.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Randhawa, Gurvaneet] Agcy Healthcare Res & Qual, Rockville, MD USA. [Armstrong, Katrina] Univ Penn, Philadelphia, PA 19104 USA. [Bennett, Charles L.] Northwestern Univ, Evanston, IL USA. [Donaldson, Molla S.] George Washington Univ, Washington, DC USA. [Follen, Michele] Univ Texas Houston, MD Anderson Canc Ctr, Houston, TX 77030 USA. [Goldie, Sue J.] Harvard Univ, Boston, MA 02115 USA. [Schrag, Deborah] Dana Farber Canc Inst, Boston, MA 02115 USA. [Khoury, Muin J.] Ctr Dis Control & Prevent, Atlanta, GA USA. [McLeod, Howard L.] Univ N Carolina, Chapel Hill, NC USA. [Piper, Margaret] Blue Cross Blue Shield Assoc Technol Evaluat Ctr, Chicago, IL USA. [Powell, Isaac] Wayne State Univ, Detroit, MI USA. [Schulman, Kevin A.] Duke Univ, Durham, NC USA. [Scott, Joan] Johns Hopkins Univ, Baltimore, MD USA. [Lewis, Graham] Univ York, Heslington, England. RP Wideroff, L (reprint author), Natl Inst Drug Abuse, Epidemiol Res Branch, Div Epidemiol Serv & Prevent Res, 6001 Executive Blvd,Suite 5153 MSC 9589, Bethesda, MD 20892 USA. EM Wideroff@nih.gov RI Hernandez, Jessica/G-6527-2011; OI Piper, Margaret/0000-0002-6231-9653 FU NCI [263-MQ-610769, 263-MQ-612315, 263-MQ-612317, 263MQ-700870, 263-MQ-701381, 263-MQ612321, 263-MQ-611969, 263-MQ-612316, 263-MQ-612323, 263-MQ-611964, 263MQ-612324, 263-MQ-611967]; [HHSN261200700005C] FX The study was funded by the NCI (263-MQ-610769 to K. A. P.; 263-MQ-612315 to K. A.; 263-MQ-612317 to C. L. B.; 263MQ-700870 to M. S. D.; 263-MQ-701381 to M. F.; 263-MQ612321 to S. J. G.; 263-MQ-611969 to R. A. H.; 263-MQ-612316 to H. L. M.; 263-MQ-612323 to I. P.; 263-MQ-611964 to D. S.; 263MQ-612324 to K. A. S.; 263-MQ-611967 to the University of York; HHSN261200700005C to Scientific Consulting Group for organizational and editorial assistance). NR 83 TC 12 Z9 12 U1 2 U2 2 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1662-4246 J9 PUBLIC HEALTH GENOMI JI Pub. Health Genomics PY 2009 VL 12 IS 4 BP 233 EP 244 DI 10.1159/000203779 PG 12 WC Genetics & Heredity; Public, Environmental & Occupational Health SC Genetics & Heredity; Public, Environmental & Occupational Health GA 432LX UT WOS:000265136600004 PM 19367091 ER PT J AU Frumkin, H Hess, J Vindigni, S AF Frumkin, Howard Hess, Jeremy Vindigni, Stephen TI Energy and Public Health: The Challenge of Peak Petroleum SO PUBLIC HEALTH REPORTS LA English DT Review ID PSYCHIATRIC IMPLICATIONS; MENTAL-HEALTH; IMPACT; FOOD; TRANSPORTATION; DISPARITIES; DISASTERS; DISTANCE; CRISIS; ASTHMA AB Petroleum is a unique and essential energy source, used as the principal fuel for transportation, in producing many chemicals, and for numerous other purposes. Global petroleum production is expected to reach a maximum in the near future and to decline thereafter, a phenomenon known as "peak petroleum." This article reviews petroleum geology and uses, describes the phenomenon of peak petroleum, and reviews the scientific literature on the timing of this transition. It then discusses how peak petroleum may affect public health and health care, by reference to four areas: medical supplies and equipment, transportation, energy generation, and food production. Finally, it suggests strategies for anticipating and preparing for peak petroleum, both general public health preparedness strategies and actions specific to the four expected health system impacts. C1 [Frumkin, Howard; Hess, Jeremy; Vindigni, Stephen] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Frumkin, Howard; Hess, Jeremy; Vindigni, Stephen] Ctr Dis Control & Prevent, Agcy Toxic Subst & Dis Registry, Atlanta, GA 30341 USA. [Hess, Jeremy; Vindigni, Stephen] Emory Med Sch, Atlanta, GA USA. RP Frumkin, H (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, 4770 Buford Hwy,MS F-61, Atlanta, GA 30341 USA. EM hfrmnkin@cdc.gov OI Frumkin, Howard/0000-0001-7079-3534 NR 125 TC 18 Z9 18 U1 2 U2 9 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD JAN-FEB PY 2009 VL 124 IS 1 BP 5 EP 19 PG 15 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 385NI UT WOS:000261820500004 PM 19413022 ER PT J AU Allen, DR Finlayson, T Abdul-Quader, A Lansky, A AF Allen, Denise Roth Finlayson, Teresa Abdul-Quader, Abu Lansky, Amy TI The Role of Formative Research in the National HIV Behavioral Surveillance System SO PUBLIC HEALTH REPORTS LA English DT Article ID QUALITATIVE RESEARCH; PREVENTION PROGRAMS; RISK; INTERVENTIONS; ANTHROPOLOGY; COMMUNITIES; HIV/AIDS; AIDS; MEN; SEX AB The National Human Immunodeficiency Virus (HIV) Behavioral Surveillance System (NHBS) is the Centers for Disease Control and Prevention's (CDC's) newest system for measuring HIV risk behaviors among three adult populations at highest risk for HIV infection in the U.S.: men who have sex with men, injecting drug users, and heterosexuals at risk of HIV infection. The system is implemented by state and local health departments in designated metropolitan statistical areas with the highest HIV/acquired immunodeficiency syndrome (AIDS) prevalence in the U.S. Prior to implementing the behavioral surveillance survey, project sites conduct a series of formative research activities. The data collected during this preparatory phase provide contextual information about HIV risk behaviors within the study population of interest and help project sites make decisions about field operations and other logistical issues. This article describes the activities undertaken in preparation for the first round of NHBS (2003-2007) and how those activities enhanced data collection for each behavioral surveillance cycle. C1 [Allen, Denise Roth; Finlayson, Teresa; Abdul-Quader, Abu; Lansky, Amy] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA 30341 USA. RP Allen, DR (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis, 4770 Buford Hwy,MS F-22, Atlanta, GA 30341 USA. EM drothallen@cdc.gov NR 36 TC 21 Z9 24 U1 1 U2 1 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD JAN-FEB PY 2009 VL 124 IS 1 BP 26 EP 33 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 385NI UT WOS:000261820500007 PM 19413025 ER PT J AU Ahluwalia, IB Bolen, J Pearson, WS Link, M Garvin, W Mokdad, A AF Ahluwalia, Indu B. Bolen, Julie Pearson, William S. Link, Michael Garvin, William Mokdad, Ali TI State and Metropolitan Variation in Lack of Health Insurance Among Working-Age Adults, Behavioral Risk Factor Surveillance System, 2006 SO PUBLIC HEALTH REPORTS LA English DT Article ID EMPLOYER-SPONSORED INSURANCE; PREVENTIVE SERVICES; UNITED-STATES; COVERAGE; REFORM; CARE; INDIVIDUALS; UNINSURANCE; AMERICANS; LESSONS AB Objective. Lack of health insurance coverage for working-age adults is one of the most pressing issues facing the U.S. population, and it continues to be a concern for a large number of people. In the absence of a national solution, the states and municipalities are left to address this need. We examined the disparities in uninsurance prevalence by state and metropolitan areas in the U.S. and among racial/ethnic groups. Method. Data from the 2006 Behavioral Risk Factor Surveillance System (BRFSS) were analyzed for working-age adults 18 to 64 years of age. Results. In 2006, according to the BRFSS data, overall 18.6% (standard error = 0.20) of working-age adults were without health insurance coverage; by state, this proportion ranged from 9.7% to 29.0%. Health insurance coverage varied by state and metropolitan area and racial/ethnic group, and a higher age-adjusted prevalence of uninsurance was observed for non-Hispanic black and Hispanic respondents. Conclusions. A substantial proportion of working-age Americans remain without health insurance coverage. Disparities in health insurance coverage were observed by population and geographic groups. Overall, black and Hispanic populations fared far worse in terms of lack of health-care coverage than working-age white Americans. C1 [Ahluwalia, Indu B.; Bolen, Julie; Pearson, William S.; Link, Michael; Garvin, William; Mokdad, Ali] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Ahluwalia, IB (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy NE,MS K-66, Atlanta, GA 30341 USA. EM iaa2@cdc.gov NR 39 TC 4 Z9 4 U1 1 U2 1 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD JAN-FEB PY 2009 VL 124 IS 1 BP 34 EP 41 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 385NI UT WOS:000261820500008 PM 19413026 ER PT J AU Braun, KVN Yeargin-Allsopp, M Lollar, D AF Braun, Kim Van Naarden Yeargin-Allsopp, Marshalyn Lollar, Donald TI Activity limitations among young adults with developmental disabilities: A population-based follow-up study SO RESEARCH IN DEVELOPMENTAL DISABILITIES LA English DT Article DE Developmental disabilities; Activity limitations; Functioning; Childhood impairment; Intellectual disabilities; Cerebral palsy; Hearing loss; Vision impairment; Epilepsy; Population-based; Follow-up; Young adulthood ID CEREBRAL-PALSY; MENTAL-RETARDATION; CHILDREN; ADL AB Developmental disabilities are a heterogeneous group of chronic conditions that may result in Substantial activity limitations. The type and number of limitations may vary by impairment characteristics, Economic and social constraints may impact activity limitations beyond those attributable to their impairment. Using the International Classification of Functioning (ICF), Disability, and Health conceptual framework, this study tests the hypothesis that activity limitations in young adulthood are not inevitable consequences of childhood impairment. The Metropolitan Atlanta Developmental Disabilities Follow-Lip Study of Young Adults, a cohort of young adults ages 21-25, is used to examine the relationship between childhood impairment and activity limitations in young adulthood. For young adults with isolated impairment, activity limitations are not probable outcomes. This Situation is not the case for those with severe intellectual disability and/or multiple impairments. The type and extent of activity limitations vary by impairment characteristics. With the goal of improving and preventing activity limitations in Young adults with various types and severities of childhood impairment, additional research is needed to further identify areas for secondary and tertiary prevention of the consequences of childhood impairment. The conceptual framework of the ICF provides a useful tool for testing hypotheses to pinpoint areas of intervention. Published by Elsevier B.V. C1 [Braun, Kim Van Naarden; Yeargin-Allsopp, Marshalyn] Ctr Dis Control & Prevent, Dev Disabil Branch, Natl Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Lollar, Donald] Ctr Dis Control & Prevent, Off Director, Natl Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Braun, KVN (reprint author), Ctr Dis Control & Prevent, Dev Disabil Branch, Natl Birth Defects & Dev Disabil, 1600 Clifton Rd MS E-86, Atlanta, GA 30333 USA. EM kbn5@cdc.gov; mxy1@cdc.gov; dcl5@cdc.gov NR 23 TC 11 Z9 11 U1 5 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0891-4222 J9 RES DEV DISABIL JI Res. Dev. Disabil. PD JAN-FEB PY 2009 VL 30 IS 1 BP 179 EP 191 DI 10.1016/j.ridd.2008.02.004 PG 13 WC Education, Special; Rehabilitation SC Education & Educational Research; Rehabilitation GA 386PW UT WOS:000261896100013 ER PT J AU Chen, RT Excler, J Laderoute, MP Mahy, BW Hendry, MP Via, CM Compingbutra, AA Gidudu, J AF Chen, R. T. Excler, J. Laderoute, M. P. Mahy, B. W. Hendry, M. P. Via, C. M. Compingbutra, A. A. Gidudu, J. TI Brighton collaboration viral vector vaccines safety working group (V3SWG): maximizing the comparability and value of safety data from HIV vaccine trials SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Chen, R. T.; Mahy, B. W.; Hendry, M. P.; Via, C. M.; Compingbutra, A. A.; Gidudu, J.] CDC, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. [Excler, J.] IAVI, New York, NY USA. [Laderoute, M. P.] Publ Hlth Agcy Canada, Ottawa, ON, Canada. NR 0 TC 0 Z9 0 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PY 2009 VL 6 AR P207 PG 2 WC Virology SC Virology GA 509KL UT WOS:000271015300258 ER PT J AU Curlin, M Celum, C Sanchez, J Selke, S Baeten, J Huang, M Zuckerman, R Lu, X Erdman, D Corey, L AF Curlin, M. Celum, C. Sanchez, J. Selke, S. Baeten, J. Huang, M. Zuckerman, R. Lu, X. Erdman, D. Corey, L. TI Intermittent rectal shedding of multiple human adenovirus serotypes among HIV-positive MSM SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Curlin, M.; Corey, L.] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Inst, Seattle, WA 98104 USA. [Celum, C.; Selke, S.; Baeten, J.; Huang, M.] Univ Washington, Sch Med, Seattle, WA USA. [Sanchez, J.] Asociac Civil Impacta Salud & Educ, Lima, Peru. [Zuckerman, R.] Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA. [Lu, X.; Erdman, D.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PY 2009 VL 6 AR P162 PG 2 WC Virology SC Virology GA 509KL UT WOS:000271015300213 ER PT J AU Heneine, W AF Heneine, Walid TI Emergence of novel retroviruses SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Heneine, Walid] Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, Atlanta, GA USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PY 2009 VL 6 AR I5 PG 1 WC Virology SC Virology GA 498MX UT WOS:000270146200006 ER PT J AU Rong, R Li, B Haaland, RE Murphy, MK Mulenga, J Allen, SA Blackwell, JL Pinter, A Shaw, GM Gnanakaran, S Hunter, E Robinson, JE Derdeyn, CA AF Rong, R. Li, B. Haaland, R. E. Murphy, M. K. Mulenga, J. Allen, S. A. Blackwell, J. L. Pinter, A. Shaw, G. M. Gnanakaran, S. Hunter, E. Robinson, J. E. Derdeyn, C. A. TI Autologous neutralizing antibodies in early subtype C HIV-1 infection target variable regions of envelope and drive multiple pathways of viral escape SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Haaland, R. E.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Mulenga, J.] Zambia Blood Transfus Serv, Lusaka, Zambia. [Pinter, A.] Univ Med & Dent New Jersey, New Jersey Med Sch, Publ Hlth Res Inst, Newark, NJ 07103 USA. [Shaw, G. M.] Univ Alabama, Birmingham, AL USA. [Gnanakaran, S.] Los Alamos Natl Lab, Los Alamos, NM USA. [Robinson, J. E.] Tulane Univ, New Orleans, LA 70118 USA. [Rong, R.; Li, B.; Murphy, M. K.; Allen, S. A.; Blackwell, J. L.; Hunter, E.; Derdeyn, C. A.] Emory Univ, Atlanta, GA 30322 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PY 2009 VL 6 AR P125 PG 1 WC Virology SC Virology GA 509KL UT WOS:000271015300177 ER PT J AU Sitbon, M Abe, H Courgnaud, V Giovannini, D Kim, F Lavanya, M Manel, N Touhami, J Switzer, WM Castelnau, P Lagrue, E Nadal-Desbarats, L de Guillen, K Roumestand, C Battini, JL AF Sitbon, Marc Abe, Hiroyuki Courgnaud, Valerie Giovannini, Donatella Kim, Felix Lavanya, Madakasira Manel, Nicolas Touhami, Jawida Switzer, Wiliam M. Castelnau, Pierre Lagrue, Emmanuelle Nadal-Desbarats, Lydie de Guillen, Karine Roumestand, Christian Battini, Jean-Luc TI Capture in the metabolic arena: co-selection of gamma and deltaretrovirus envelope glycoproteins and their receptors SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Sitbon, Marc; Abe, Hiroyuki; Courgnaud, Valerie; Giovannini, Donatella; Kim, Felix; Lavanya, Madakasira; Manel, Nicolas; Touhami, Jawida; Battini, Jean-Luc] Univ Montpellier 1, CNRS, IGMM, UMR 5535, F-34293 Montpellier 5, France. [Sitbon, Marc; Abe, Hiroyuki; Courgnaud, Valerie; Giovannini, Donatella; Kim, Felix; Lavanya, Madakasira; Manel, Nicolas; Touhami, Jawida; Battini, Jean-Luc] Univ Montpellier 2, IFR 122, F-34293 Montpellier, France. [Switzer, Wiliam M.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Castelnau, Pierre; Lagrue, Emmanuelle] CHRU Tours, Ctr Pediat Gatien de Clocheville, Serv Neurol & Neurochirurg Pediat, F-37044 Tours 01, France. [Nadal-Desbarats, Lydie] Univ Tours, INSERM, U930, F-37032 Tours, France. [de Guillen, Karine; Roumestand, Christian] Univ Montpellier 1, INSERM, CNRS 554, CBS,UMR 5048, F-34090 Montpellier, France. RI Sitbon, Marc/A-6771-2010 OI Sitbon, Marc/0000-0003-3616-2338 NR 0 TC 0 Z9 0 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PY 2009 VL 6 AR I20 PG 2 WC Virology SC Virology GA 498MX UT WOS:000270146200021 ER PT J AU Aldoory, L AF Aldoory, Linda BE Heath, RL Toth, EL Waymer, D TI FEMINIST CRITICISM IN PUBLIC RELATIONS How Gender Can Impact Public Relations Texts and Contexts SO RHETORICAL AND CRITICAL APPROACHES TO PUBLIC RELATIONS SE Communication Series Routledge LA English DT Article; Book Chapter ID WOMEN; PARADIGM; IDENTITY; MEDIA C1 [Aldoory, Linda] Univ Maryland, Commun & Affiliate Fac Womens Studies, College Pk, MD 20742 USA. [Aldoory, Linda] US Ctr Dis Control & Prevent, Atlanta, GA USA. RP Aldoory, L (reprint author), Univ Maryland, Commun & Affiliate Fac Womens Studies, College Pk, MD 20742 USA. NR 60 TC 9 Z9 9 U1 0 U2 0 PU ROUTLEDGE PI LONDON PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND BN 978-0-203-87492-9 J9 COMMUN SER PY 2009 BP 110 EP 123 PG 14 WC Communication SC Communication GA BNC00 UT WOS:000274104900008 ER PT S AU Eremeeva, ME Dasch, GA AF Eremeeva, Marina E. Dasch, Gregory A. BE Hechemy, KE Brouqui, P Samuel, JE Raoult, DA TI Closing the Gaps between Genotype and Phenotype in Rickettsia rickettsii SO RICKETTSIOLOGY AND RICKETTSIAL DISEASES SE Annals of the New York Academy of Sciences LA English DT Article; Proceedings Paper CT 5th International Conference on Rickettsiae and Rickettsial Diseases CY MAY 18-20, 2008 CL Marseilles, FRANCE SP European Study Grp, Amer Soc Rickettisol DE Rickettsia rickettsii; genotyping; VNTR; INDEL; intergenic region ID MOUNTAIN-SPOTTED-FEVER; GENE REPEAT REGION; DERMACENTOR-ANDERSONI; UNITED-STATES; MONOCLONAL-ANTIBODIES; MINAS-GERAIS; TICK VECTOR; WOOD TICK; INFECTION; IDENTIFICATION AB Rocky Mountain spotted fever (RMSF) caused by Rickettsia rickettsii is a severe rickettsiosis that occurs in nearly every state of the continental USA. RMSF is endemic in Central and Southern America, with recent well-documented cases in Mexico, Costa Rica, Panama, Colombia, Brazil, and Argentina. RMSF is the most malignant among known rickettsioses causing severe multiorgan dysfunction and high case fatality rates, which can reach 73% in untreated cases. Variations in pathogenic biotypes of R. rickettsii isolates have been described, and potential correlations of these differences to various clinical manifestations of RMSF have been suggested. We have recently reported on a method of genetic comparison employing sequence differences in intergenic regions (IGR typing) in isolates of R. rickettsii of human, tick, and animal origin. The grouping obtained correlated well with 2 other genotyping systems we have developed, which target the presence and distribution of variable numbers of tandem repeats (TR) and insertion/deletion (INDEL) events. Twenty-five total genotypes of R. rickettsii in 4 primary groups could be distinguished: isolates from Montana, isolates associated with Rhipicephalus sanguineus ticks and human infections in Arizona, other isolates from the USA where Dermacentor variabilis is thought to be the primary vector, and the isolates primarily associated with Amblyomma ticks from Central and South America. In addition, isolate Hlp#2, which is often considered to be a nonpathogenic isolate of R. rickettsii and closely related serotype 364D, exhibited the most diversity from the other isolates compared, and they differ significantly from each other. Because complex interactions underlie the pathogenesis of R. rickettsii in vivo, it is difficult to define the causality of individual events that occur in infected vertebrate hosts and humans. Many microbial factors are likely to contribute to the varied ability of R. rickettsii to cause cellular injury; some of them may also contribute importantly to its virulence for vertebrate hosts and may be linked to the variable genetic markers we have identified. Since circulation of R. rickettsii in nature includes vertical transstadial and transovarial transmission within tick vectors and horizontal passages through vertebrate hosts, it is plausible that isolates of different virulence arose when they became isolated during adaptation to novel vertebrate and tick hosts. Characterization of the physiologically important changes in rickettsial gene expression that occur immediately after tick-to-human or tick-to-animal transitions may require development of new experimental systems. C1 [Eremeeva, Marina E.] Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Natl Ctr Zoonot Vectorborne & Enter Dis, Div Viral & Rickettsial Dis, Atlanta, GA 30333 USA. RP Eremeeva, ME (reprint author), Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Natl Ctr Zoonot Vectorborne & Enter Dis, Div Viral & Rickettsial Dis, Mail Stop G-13,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM MEremeeva@cdc.gov OI Dasch, Gregory/0000-0001-6090-1810 NR 72 TC 14 Z9 14 U1 0 U2 7 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA SN 0077-8923 BN 978-1-57331-750-4 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 2009 VL 1166 BP 12 EP 26 DI 10.1111/j.1749-6632.2009.04526.x PG 15 WC Infectious Diseases; Multidisciplinary Sciences; Parasitology SC Infectious Diseases; Science & Technology - Other Topics; Parasitology GA BJV56 UT WOS:000267264400002 PM 19538260 ER PT S AU Chao, CC Garland, DL Dasch, GA Ching, WM AF Chao, Chien-Chung Garland, Donita L. Dasch, Gregory A. Ching, Wei-Mei BE Hechemy, KE Brouqui, P Samuel, JE Raoult, DA TI Comparative Proteomic Analysis of Antibiotic-Sensitive and Insensitive Isolates of Orientia tsutsugamushi SO RICKETTSIOLOGY AND RICKETTSIAL DISEASES SE ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article; Proceedings Paper CT 5th International Conference on Rickettsiae and Rickettsial Diseases CY MAY 18-20, 2008 CL Marseilles, FRANCE DE Orientia tsutsugamushi; Proteomic; antibiotic sensitive ID SCRUB TYPHUS; RESISTANCE AB Scrub typhus, caused by infection with Orientia tsutsugamushi, is probably the most common severe rickettsial disease. Early diagnosis followed by treatment with antibiotics such as doxycycline or chloramphenicol usually quickly decreases fever in patients, and they often recover well from other symptoms of the disease. However, poorly responsive cases have been reported from northern Thailand and southern India. In order to identify protein factors that may be partially responsible for differential drug sensitivity of isolates of Orientia, we compared the protein profiles of doxycycline sensitive (Karp) versus (vs.) insensitive (AFSC4 and AFSC7) isolates. Tryptic peptides from both total water-soluble proteins and from protein spots separated by 2D-PAGE were analyzed using LC-MS/MS. The identity of each protein was established using the published genomic sequence of Boryong strain O. tsutsugamushi. The profiles of protein released into water from these isolates were quite different. There were 10 proteins detected only in AFSC4, 3 only in Karp, and I only in AFSC7. Additionally, there were 2 proteins not detected only in AFSC4,4 not found only in Karp, and 3 not found only in AFSC-7. A comparison of 2D-PAGE protein profiles of drug sensitive strain versus (vs.) insensitive isolates has led to the identification of 14 differentially expressed or localized proteins, including elongation factor Ts and Tu, DNA-directed RNA polymerase alpha-subunit, ATP synthase beta-subunit, and several hypothetical proteins. These data confirm the tremendous proteomic diversity of isolates of Orientia and suggest that drug insensitivity in this species may arise from multiple mechanisms. C1 [Chao, Chien-Chung; Ching, Wei-Mei] USN, VRDD, IDD, Med Res Ctr, Silver Spring, MD 20910 USA. [Garland, Donita L.] NEI, NIH, Bethesda, MD 20892 USA. [Dasch, Gregory A.] Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Atlanta, GA 30333 USA. [Ching, Wei-Mei] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Chao, CC (reprint author), USN, VRDD, IDD, Med Res Ctr, 503 Robert Grant Ave,RM3N71, Silver Spring, MD 20910 USA. EM chien-chung.chao@med.navy.mil RI Chao, Chien-Chung/A-8017-2011; OI Dasch, Gregory/0000-0001-6090-1810 FU Work Unit Number (WUN [6000.RAD1.J.A0310] FX The authors wish to thank Ms. Kynita Winn for her help in 2D-PAGE analysis and Dr. Paul Graf for his review of the manuscript. This work was Supported by Work Unit Number (WUN) 6000.RAD1.J.A0310. The opinions and assertions contained herein are the private ones of the authors and are not to be construed as official or as reflecting the views of the Department of the Navy, the naval service at large, the Department of Defense, the Centers for Disease Control and Prevention, the Department of Health and Human Services, or the U. S. Government. Authors C. C. Chao, G. A. Dasch, and W M. Ching are employees of the U. S. Government. This work was prepared as part of official duties. NR 18 TC 4 Z9 4 U1 1 U2 3 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXEN, ENGLAND SN 0077-8923 BN 978-1-57331-750-4 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 2009 VL 1166 BP 27 EP 37 DI 10.1111/j.1749-6632.2009.04525.x PG 11 WC Infectious Diseases; Multidisciplinary Sciences; Parasitology SC Infectious Diseases; Science & Technology - Other Topics; Parasitology GA BJV56 UT WOS:000267264400003 PM 19538261 ER PT S AU Paddock, CD AF Paddock, Christopher D. BE Hechemy, KE Brouqui, P Samuel, JE Raoult, DA TI The Science and Fiction of Emerging Rickettsioses SO RICKETTSIOLOGY AND RICKETTSIAL DISEASES SE ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article; Proceedings Paper CT 5th International Conference on Rickettsiae and Rickettsial Diseases CY MAY 18-20, 2008 CL Marseilles, FRANCE DE rickettsiosis; Rickettsia; emerging infections ID SPOTTED-FEVER GROUP; MOUNTAIN WOOD TICK; UNITED-STATES; DERMACENTOR-ANDERSONI; CELL-LINE; RHIPICEPHALUS-SANGUINEUS; WESTERN MONTANA; INFECTED TICKS; TYPHUS GROUP; CAT FLEAS AB As newly recognized rickettsial diseases and rickettsial pathogens increase in scope and magnitude, several elements related to the concept of emerging rickettsioses deserve consideration. Newly identified rickettsiae may be mildly pathogenic, or perhaps even nonpathogenic, and have little direct impact on human or animal health, yet nonetheless wield considerable influence on the epidemiology and ecology of historically recognized diseases. In this context "new" rickettsioses provide a lens through which "old" rickettsioses are more accurately represented. Predicting pathogen from nonpathogen is not an exact science, particularly as so few rickettsiae have been broadly accepted as nonpathogenic by contemporary rickettsiologists. However, various factors relating to specific physiologic requirements and molecular machinery of the particular rickettsia, as well as characteristics of its invertebrate host that either position or exclude the rickettsia from infecting a human host, must be considered. Close inspection of mild or atypical forms of historically recognized rickettsioses and a greater emphasis on culture- and molecular-based diagnostic techniques are the keys to identifying future rickettsial agents of disease. C1 Ctr Dis Control & Prevent, Infect Dis Pathol Branch, Div Viral & Rickettsial Dis, Atlanta, GA 30333 USA. RP Paddock, CD (reprint author), Ctr Dis Control & Prevent, Infect Dis Pathol Branch, Div Viral & Rickettsial Dis, Mailstop G-32,1600 Clifton Rd, Atlanta, GA 30333 USA. EM CPaddock@cdc.gov NR 91 TC 15 Z9 15 U1 0 U2 5 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXEN, ENGLAND SN 0077-8923 BN 978-1-57331-750-4 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 2009 VL 1166 BP 133 EP 143 DI 10.1111/j.1749-6632.2009.04529.x PG 11 WC Infectious Diseases; Multidisciplinary Sciences; Parasitology SC Infectious Diseases; Science & Technology - Other Topics; Parasitology GA BJV56 UT WOS:000267264400015 PM 19538273 ER PT J AU Smith, B Kemp, M Ethelberg, S Schiellerup, P Bruun, B Gerner-Smidt, P Christensen, J AF Smith, Birgitte Kemp, Michael Ethelberg, Steen Schiellerup, Peter Bruun, Brita G. Gerner-Smidt, Peter Christensen, Jens J. TI Listeria monocytogenes: Maternal-foetal infections in Denmark 1994-2005 SO SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID PERINATAL LISTERIOSIS; PREGNANCY AB Maternal-foetal infection by Listeria monocytogenes is a rare complication in pregnancy. In the period 1994-2005, 37 culture-confirmed cases of maternal-foetal Listeria monocytogenes infections were reported in Denmark. We examined 36 patients' files in order to evaluate risk factors, clinical and laboratory findings, response to therapy, and outcome for maternal-foetal listeriosis. Patient data and bacteriological findings were divided into 2 groups for comparison: 1 group with children born alive (n = 24) and another group with abortion or stillbirth (n = 12). 23 of the 36 children survived the acute infection, as did all the mothers. The mothers were generally only mildly affected by the infection. In contrast, among the children born alive, 15 were diagnosed with bacteraemia/septicaemia, 3 children with pneumonia, 3 with neonatal meningitis, and 3 were unaffected. Despite the high frequency of illness only 1 of the live-born children died from the infection and none of the surviving children showed signs of permanent damage at the time they were discharged from hospital. Listeriosis during pregnancy is a serious threat to the unborn child. One-third of culture-confirmed cases of maternal-foetal infections resulted in abortion or stillbirth; however, the prognosis for live-born children is good, even in severely ill newborns. C1 [Smith, Birgitte; Kemp, Michael; Ethelberg, Steen; Christensen, Jens J.] Statens Serum Inst, Dept Bacteriol Mycol & Parasitol, DK-2300 Copenhagen S, Denmark. [Schiellerup, Peter] Herlev Hosp, Dept Gastroenterol, DK-2730 Herlev, Denmark. [Bruun, Brita G.] Cent Hosp Hillerod, Dept Clin Microbiol, Hillerod, Denmark. [Gerner-Smidt, Peter] Ctr Dis Control & Prevent, Enter Dis Lab Branch, Atlanta, GA USA. RP Smith, B (reprint author), Statens Serum Inst, Dept Bacteriol Mycol & Parasitol, Artillerivej 5, DK-2300 Copenhagen S, Denmark. EM BGS@SSI.dk OI Kemp, Michael/0000-0001-5989-0421; Ethelberg, Steen/0000-0002-9709-356X NR 15 TC 32 Z9 35 U1 0 U2 9 PU TAYLOR & FRANCIS AS PI OSLO PA KARL JOHANS GATE 5, NO-0154 OSLO, NORWAY SN 0036-5548 J9 SCAND J INFECT DIS JI Scand. J. Infect. Dis. PY 2009 VL 41 IS 1 BP 21 EP 25 DI 10.1080/00365540802468094 PG 5 WC Infectious Diseases SC Infectious Diseases GA 386HU UT WOS:000261874000004 PM 18855227 ER PT J AU Rubin, J David, D Willoughby, RE Rupprecht, CE Garcia, C Guarda, DC Zohar, Z Stamler, A AF Rubin, Joshua David, Dan Willoughby, Rodney E., Jr. Rupprecht, Charles E. Garcia, Cecilia Guarda, Dario C. Zohar, Zmora Stamler, Alon TI Applying the Milwaukee Protocol to treat canine rabies in Equatorial Guinea SO SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES LA English DT Editorial Material ID INFECTION; VIRUS; COMA AB In this first report of rabies in Equatorial Guinea, problems accompanying the application of the Milwaukee Protocol are described. With its apparent success, and despite a subsequent death from complications of malnutrition, we sound a note of optimism that canine as well as bat rabies may be treatable. C1 [Rubin, Joshua; Garcia, Cecilia; Guarda, Dario C.; Zohar, Zmora; Stamler, Alon] Ctr Med La Paz, Bata, Equat Guinea. [David, Dan] Kimron Vet Inst, IL-50250 Bet Dagan, Israel. [Willoughby, Rodney E., Jr.] Med Coll Wisconsin, Milwaukee, WI 53226 USA. [Rupprecht, Charles E.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Rubin, J (reprint author), Ctr Med La Paz, Bata, Equat Guinea. EM jsh.rbn@gmail.com NR 13 TC 25 Z9 29 U1 2 U2 9 PU TAYLOR & FRANCIS AS PI OSLO PA KARL JOHANS GATE 5, NO-0154 OSLO, NORWAY SN 0036-5548 J9 SCAND J INFECT DIS JI Scand. J. Infect. Dis. PY 2009 VL 41 IS 5 BP 372 EP 375 AR PII 909231061 DI 10.1080/00365540902798333 PG 4 WC Infectious Diseases SC Infectious Diseases GA 434VL UT WOS:000265302100008 PM 19263274 ER PT J AU Fasula, AM Miller, KS Sutton, MY AF Fasula, Amy M. Miller, Kim S. Sutton, Madeline Y. TI An early warning sign: sexually transmissible infections among young African American women and the need for preemptive, combination HIV prevention SO SEXUAL HEALTH LA English DT Editorial Material ID TRANSMITTED-DISEASES; RISK; DISPARITIES; COMMUNITIES; PATTERNS; BEHAVIOR C1 [Fasula, Amy M.; Miller, Kim S.; Sutton, Madeline Y.] US Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. RP Fasula, AM (reprint author), US Ctr Dis Control & Prevent, Div HIV AIDS Prevent, 1600 Clifton Rd NE,Mail Stop E-37, Atlanta, GA 30333 USA. EM afasula@cdc.gov NR 26 TC 1 Z9 1 U1 1 U2 2 PU CSIRO PUBLISHING PI COLLINGWOOD PA 150 OXFORD ST, PO BOX 1139, COLLINGWOOD, VICTORIA 3066, AUSTRALIA SN 1448-5028 J9 SEX HEALTH JI Sex Health PY 2009 VL 6 IS 4 BP 261 EP 263 DI 10.1071/SH09084 PG 3 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 518QK UT WOS:000271708000001 PM 20157941 ER PT J AU Leichliter, JS Aral, S AF Leichliter, Jami S. Aral, Sevgi TI Black Women in the United States Decrease Their Number of Recent Sex Partners: Temporal Trends From the National Survey of Family Growth SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID SOCIAL-CONTEXT; HIV/AIDS; HIV; DISPARITIES; PREVALENCE; BEHAVIORS C1 [Leichliter, Jami S.; Aral, Sevgi] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30333 USA. RP Leichliter, JS (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, 1600 Clifton Rd,MS E-44, Atlanta, GA 30333 USA. EM JLeichliter@cdc.gov NR 26 TC 6 Z9 6 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JAN PY 2009 VL 36 IS 1 BP 1 EP 3 DI 10.1097/OLQ.0b013e3181845b84 PG 3 WC Infectious Diseases SC Infectious Diseases GA 389FM UT WOS:000262076600001 PM 18724269 ER PT J AU Anschuetz, GL Beck, JN Asbel, L Goldberg, M Salmon, ME Spain, CV AF Anschuetz, Greta L. Beck, Jennifer N. Asbel, Lenore Goldberg, Martin Salmon, Melinda E. Spain, C. Victor TI Determining Risk Markers for Gonorrhea and Chlamydial Infection and Reinfection Among Adolescents in Public High Schools SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID NEISSERIA-GONORRHOEAE; TRACHOMATIS INFECTION; YOUNG-ADULTS; WOMEN; SETTINGS; AZITHROMYCIN; RECURRENCE; DETENTION; CENTERS; COHORT AB Background: In response to high adolescent rates of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (G. C), Philadelphia began screening in all public high schools in 2003. Methods: Data from 14,862 students who tested more than once in the Philadelphia High School STD Screening Program (PHSSSP) during the 2002-2006 school years were analyzed for factors associated with CT and GC infection. Multivariable Cox proportional hazards models and logistic regression models were constructed to identify characteristics associated with measured STD rates. A secondary analysis assessed short-term reinfection rates among participants retesting within the same school year. Results: In the primary analysis, over multiple years, the unadjusted female CT/GC rate was more than double that in males (6.0 vs. 2.4 cases per 100 person-years, respectively). Among students with a baseline positive, males had a higher rate than females (19.9 vs. 17.7 cases per 100 person-years, respectively). Among students with a positive test result, 13.6% were reinfected within the same school year. Females with named partners, not treated had a higher reinfection rate than all others (85.5 vs. 40.1-45.2 cases per 100 person-years, respectively). Conclusions: Clinicians and screening programs that offer STD testing to urban high school students, regardless of gender, should encourage those with a prior STD history to test more frequently. Clinicians should work with infected patients, especially females, to ensure their partners are treated. C1 [Anschuetz, Greta L.] Philadelphia Dept Publ Hlth, Div Dis Control, Philadelphia, PA 19146 USA. [Beck, Jennifer N.] Drexel Univ, Sch Publ Hlth, Philadelphia, PA 19104 USA. [Asbel, Lenore] Drexel Univ, Coll Med, Philadelphia, PA 19104 USA. [Salmon, Melinda E.] Ctr Dis Control & Prevent, NCHHSTP, Philadelphia, PA USA. RP Anschuetz, GL (reprint author), Philadelphia Dept Publ Hlth, Div Dis Control, 500 S Broad St, Philadelphia, PA 19146 USA. EM greta.anschuetz@phila.gov NR 23 TC 21 Z9 21 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JAN PY 2009 VL 36 IS 1 BP 4 EP 8 DI 10.1097/OLQ.0b013e3181860108 PG 5 WC Infectious Diseases SC Infectious Diseases GA 389FM UT WOS:000262076600002 PM 18813031 ER PT J AU Habel, MA Hogben, M AF Habel, Melissa A. Hogben, Matthew TI Public Health Guidance Dissemination via the Internet: Expedited Partner Therapy SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID SEXUALLY-TRANSMITTED-DISEASE; CONTROLLED-TRIAL; CHLAMYDIA-TRACHOMATIS; INFECTION; MEDICATION; RECURRENT C1 [Habel, Melissa A.; Hogben, Matthew] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30333 USA. RP Habel, MA (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, Mail Stop E-44, Atlanta, GA 30333 USA. EM rnhabel@cdc.gov NR 18 TC 1 Z9 1 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JAN PY 2009 VL 36 IS 1 BP 22 EP 24 DI 10.1097/OLQ.0b013e318188673c PG 3 WC Infectious Diseases SC Infectious Diseases GA 389FM UT WOS:000262076600006 PM 19008774 ER PT J AU Person, B Bartholomew, LK Gyapong, M Addiss, DG van den Borne, B AF Person, Bobbie Bartholomew, L. Kay Gyapong, Margaret Addiss, David G. van den Borne, Bart TI Health-related stigma among women with lymphatic filariasis from the Dominican Republic and Ghana SO SOCIAL SCIENCE & MEDICINE LA English DT Article DE Dominican Republic; Ghana; Lymphatic filariasis; Women; Stigma; Coping; Chronic illness ID MORAL EXPERIENCE; SOUTH-INDIA; RURAL-AREAS; BELIEFS; PEOPLE; ATTITUDES; CULTURE; DISEASE; LEPROSY AB People fearful of being stigmatized by a health-related condition often do not embrace prevention behaviors or seek medical help. They may adhere poorly to treatment regimes for disease and abruptly terminate much needed treatment. Globally, 120 million-many poor women-suffer consequences of lymphatic filariasis that include stigmatizing lymphedema or elephantiasis of the leg. We investigated how women with lymphedema from two different cultures experience stigma and its consequences. Our qualitative data were collected from 56 Dominican women and 48 Ghanaian women with lymphedema. A lymphedema-related stigma framework was developed from constructs derived from the literature and emergent themes from the data. Women described a spectrum of enacted, perceived, and internalized stigma experiences, such as being criticized and isolated by the community, health providers, and even by friends and relatives; they were often denied access to education and meaningful work roles. Some antecedents, consequences, coping strategies, and outcomes of these experiences varied across cultures, with Dominican women faring somewhat better than Ghanaians. Poverty, poor access to health care resources, limited education, and diminished social support challenged the coping strategies of many women and exacerbated negative consequences of lymph edema-related stigma. Published by Elsevier Ltd. C1 [Person, Bobbie] Ctr Dis Control & Prevent, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA 30333 USA. [Bartholomew, L. Kay] Univ Texas Hlth Sci Ctr Houston, Houston, TX USA. [Gyapong, Margaret] Dodowa Hlth Res Ctr, Dodowa, Ghana. [Addiss, David G.] Fetzer Inst, Kalamazoo, MI USA. [van den Borne, Bart] Univ Maastricht, NL-5071 CL Undenhout, Netherlands. RP Person, B (reprint author), Ctr Dis Control & Prevent, Natl Ctr Preparedness Detect & Control Infect Dis, 1600 Clifton Rd,Mailstop C-14, Atlanta, GA 30333 USA. EM bobbieperson@gmail.com; leona.k.bartholomew@uth.tmc.edu; margaret.gyapong@hru-ghs.org; daddiss@fetzer.org; b.vdborne@gvo.unimaas.nl NR 38 TC 29 Z9 30 U1 1 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0277-9536 J9 SOC SCI MED JI Soc. Sci. Med. PD JAN PY 2009 VL 68 IS 1 BP 30 EP 38 DI 10.1016/j.socscimed.2008.09.040 PG 9 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA 399JL UT WOS:000262796100005 PM 18992982 ER PT S AU Cardarelli, KM Low, MD Vernon, SW Preacely, N Baumler, ER Tortolero, S AF Cardarelli, Kathryn M. Low, M. David Vernon, Sally W. Preacely, Nykiconia Baumler, Elizabeth R. Tortolero, Susan BE Ronenfeld, JJ TI CRITICAL REVIEW OF THE EVIDENCE FOR THE CONNECTION BETWEEN EDUCATION AND HEALTH: A GUIDE FOR EXPLORATION OF THE CAUSAL PATHWAYS SO SOCIAL SOURCES OF DISPARITIES IN HEALTH AND HEALTH CARE AND LINKAGES TO POLICY, POPULATION CONCERNS AND PROVIDERS OF CARE SE Research in the Sociology of Health Care LA English DT Review; Book Chapter ID CORONARY-HEART-DISEASE; CAUSE-SPECIFIC MORTALITY; ALL-CAUSE MORTALITY; MIDDLE-AGED MEN; RISK-FACTORS; SOCIOECONOMIC-STATUS; SOCIAL-CLASS; CARDIOVASCULAR-DISEASE; UNITED-STATES; LIFE-COURSE AB The association between education and health is one of the most robust empiric findings over the past several decades. At each higher level of education, prevalence of most types of chronic disease decreases. However, understanding of the mechanisms through which education is related to chronic disease is limited. Specifically, the literature provides little and health. Better scientific understanding of the pathways through which education influences health may help to explain the well-documented association between socioeconomic position (SEP) and health and could lead to improved intervention strategies for health disparities. We review the potential pathways through which education may influence health and the evidence that explicitly tests these hypothesized pathways and provide direction for future research in this field. C1 [Cardarelli, Kathryn M.] Univ N Texas, Hlth Sci Ctr, Sch Publ Hlth, Ctr Community Hlth, Ft Worth, TX USA. [Vernon, Sally W.; Baumler, Elizabeth R.; Tortolero, Susan] Univ Texas Houston, Sch Publ Hlth, Div Hlth Promot & Behav Sci, Houston, TX USA. [Low, M. David] Univ Texas Houston, Sch Publ Hlth, Dept Management & Policy Sci, Houston, TX USA. [Preacely, Nykiconia] Ctr Dis Control & Prevent, Epidemiol Program Off, Atlanta, GA USA. RP Cardarelli, KM (reprint author), Univ N Texas, Hlth Sci Ctr, Sch Publ Hlth, Ctr Community Hlth, Ft Worth, TX USA. NR 146 TC 0 Z9 0 U1 2 U2 8 PU EMERALD GROUP PUBLISHING LIMITED PI BINGLEY PA HOWARD HOUSE, WAGON LANE, BINGLEY, W YORKSHIRE BD16 1WA, ENGLAND SN 0275-4959 BN 978-1-84855-834-2 J9 RES SOCIOL HEALTH CA PY 2009 VL 27 BP 137 EP 159 DI 10.1108/S0275-4959(2009)0000027009 PG 23 WC Health Policy & Services; Public, Environmental & Occupational Health; Sociology SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Sociology GA BOM21 UT WOS:000276983500007 ER PT J AU Eng, B Cain, KP Nong, K Chhum, V Sin, E Roeun, S Kim, S Keo, S Heller, TA Varma, JK AF Eng, Bunthoeun Cain, Kevin P. Nong, Kanara Chhum, Vannarith Sin, Eap Roeun, Sothy Kim, Sameourn Keo, Samnang Heller, Thomas A. Varma, Jay K. TI IMPACT OF A PUBLIC ANTIRETROVIRAL PROGRAM ON TB/HIV MORTALITY: BANTEAY MEANCHEY, CAMBODIA SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH LA English DT Article AB The WHO recommends antiretroviral therapy (ART) for most HIV-infected tuberculosis patients. To assess the impact of ART on tuberculosis case-fatality rates in Cambodia, we compared treatment outcomes of patients newly diagnosed with tuberculosis in 2004 (before implementation of ART clinics) with outcomes of patients diagnosed in 2005 (after these clinics opened). In 2004, 37% of HIV-infected tuberculosis patients died during TB treatment compared with 5% of HIV-uninfected tuberculosis patients. In 2005, 18% of HIV-infected tuberculosis patients died compared with 51% of HIV-uninfected tuberculosis patients. The case-fatality rate for HIV-associated tuberculosis decreased from 2004 to 2005, coincident with the introduction of ART. C1 [Cain, Kevin P.; Varma, Jay K.] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Eng, Bunthoeun; Nong, Kanara; Heller, Thomas A.] CDC Global AIDS Program Cambodia, Phnom Penh, Cambodia. [Varma, Jay K.] US CDC Collaborat, Thailand Minist Publ Hlth, Nonthaburi, Thailand. RP Cain, KP (reprint author), 1600 Clifton Rd,MS E-10, Atlanta, GA 30333 USA. EM kcain@cdc.gov FU United States Agency for International Development (USAID) FX The authors thank the United States Agency for International Development (USAID) for funding the TB/HIV project in Banteay Meanchey. They also acknowledge Banteay Meanchey TB/HIV and VCCT staff and staff of the Banteay Meanchey Provincial Health Department for providing valuable information. NR 10 TC 4 Z9 4 U1 0 U2 0 PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION PI BANGKOK PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND SN 0125-1562 J9 SE ASIAN J TROP MED JI Southeast Asian J. Trop. Med. Public Health PD JAN PY 2009 VL 40 IS 1 BP 89 EP 92 PG 4 WC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine SC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine GA 430NC UT WOS:000264994800013 PM 19323039 ER PT J AU Mankatittham, W Likanonsakul, S Thawornwan, U Kongsanan, P Kittikraisak, W Burapat, C Akksilp, S Sattayawuthipong, W Srinak, C Nateniyom, S Tasaneeyapan, T Varma, JK AF Mankatittham, Wiroj Likanonsakul, Sirirat Thawornwan, Unchana Kongsanan, Paweena Kittikraisak, Wanitchaya Burapat, Channawong Akksilp, Somsak Sattayawuthipong, Wanchai Srinak, Chawin Nateniyom, Sriprapa Tasaneeyapan, Theerawit Varma, Jay K. TI CHARACTERISTICS OF HIV-INFECTED TUBERCULOSIS PATIENTS IN THAILAND SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH LA English DT Article AB To improve understanding about the epidemiology and clinical features of HIV-associated tuberculosis (TB) infection we conducted a prospective, multi-center observational Study of HIV-infected TB patients in Thailand. We enrolled HIV-infected patients diagnosed with TB at public health facilities from three provinces and the national infectious diseases referral hospital in Thailand. Patients underwent standardized interviews, evaluations, and laboratory testing at the beginning of TB treatment. We analyzed demographic and clinical characteristics of patients and stratified Our findings by level of immune-suppression and whether antiretroviral therapy (ART) was used before TB diagnosis. Of 769 patients analyzed, pulmonary TB was diagnosed in 461 (60%). The median CD4+ T-lymphocyte (CD4) count was 63 cells/mu l [interquartile range (IQR), 23-163.5] and the median HIV RNA viral load was 308,000 copies/ml (IQR, 51,900-759,000) at the time of TB diagnosis. Methamphetamine use was reported by 304 patients (40%), marijuana by 267 patients (35%), and injection drug use by 199 patients (26%). Three hundred three patients (40%) reported having been previously incarcerated. Among sexually active patients, 142 (42%) reported never using condoms at all. Patients with CD4 counts <200 cells/mu l were significantly more likely than patients with CD4 counts >= 200 cells/mu l to have extra-pulmonary TB, fever, fatigue, muscle weakness, no hemoptysis, tachycardia, low body mass index, jaundice or no pleural effusion. Of the 94 patients that received ART before TB diagnosis, the median time from ART initiation to TB diagnosis was 105 days (IQR, 31-468). HIV-infected patients who developed TB after ART initiation were more likely than other HIV-infected TB patients to have extra-pulmonary TB, a normal chest radiograph, low HIV RNA viral load, or a history of previous TB treatment. C1 [Kittikraisak, Wanitchaya; Burapat, Channawong; Tasaneeyapan, Theerawit; Varma, Jay K.] US Ctr Dis Control & Prevent Collaborat, Thailand Minist Publ Hlth, Nonthaburi, Thailand. [Akksilp, Somsak] Off Dis Prevent & Control 7, Ubon Ratchathani, Thailand. [Sattayawuthipong, Wanchai] Phuket Prov Hlth Off, Phuket, Thailand. [Srinak, Chawin] Bangkok Metropolitan Adm, Bangkok, Thailand. [Nateniyom, Sriprapa] Thailand Minist Publ Hlth, Nonthaburi, Thailand. [Varma, Jay K.] US Ctr Dis Control & Prevent, Atlanta, GA USA. RP Varma, JK (reprint author), US Embassy Beijing, CDC Sect, 3 Xiu Shui Bei Jie, Beijing 100600, Peoples R China. EM jvarma@cdc.gov FU US Agency for International Development FX This project was funded by the US Agency for International Development. The funding agency had no role in the study design, conduct, data analysis, or manuscript preparation. NR 19 TC 13 Z9 13 U1 0 U2 1 PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION PI BANGKOK PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND SN 0125-1562 J9 SE ASIAN J TROP MED JI Southeast Asian J. Trop. Med. Public Health PD JAN PY 2009 VL 40 IS 1 BP 93 EP 103 PG 11 WC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine SC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine GA 430NC UT WOS:000264994800014 PM 19323040 ER PT J AU Smith, JP Martin, A Sammons, DL Striley, C Biagini, R Quinn, J Cope, R Snawder, JE AF Smith, Jerome P. Martin, Aaron Sammons, Deborah L. Striley, Cynthia Biagini, Raymond Quinn, John Cope, Rick Snawder, John E. TI Measurement of methamphetamine on surfaces using surface plasmon resonance SO TOXICOLOGY MECHANISMS AND METHODS LA English DT Article DE Competitive immunoassay; methamphetamine surface measurement; surface plasmon resonance (SPR) AB Field methods are needed to assess the contamination of surfaces by methamphetamine from illicit drug manu facturing. This study performed a feasibility study on the use of a surface plasmon resonance (SPR) based instrument (SensiQ Discovery) in the evaluation of surface contamination by methamphetamine. The main goal was to see if the method could be sensitive enough for field measurements. A competitive immunochemical assay was developed for the instrument which was able to measure methamphetamine at 9 ng/ml with a range of 9-250 ng/ml. Methamphetamine was spiked onto ceramic tiles and the assay was able to detect methamphet amine contamination at 25 ng/100 cm(2), which is below the 50 ng/100 cm(2) standard used for surface cleanup assessment. The instrument is compact and mobile and is sensitive enough for use for measurement of meth amphetamine on surfaces, so it is a candidate for a field method for methamphetamine surface contamination. Its use for this application will require further development of the instrument to make it more convenient to use. Also further evaluation of ruggedness and use of the instrument under various environmental conditions such as temperature and humidity are needed to define conditions under which the instrument can be employed in field measurements. C1 [Smith, Jerome P.; Sammons, Deborah L.; Striley, Cynthia; Biagini, Raymond; Snawder, John E.] NIOSH, Biomonitoring Res Team, Biomonitoring & Hlth Assessment Branch, Cincinnati, OH 45226 USA. [Martin, Aaron; Quinn, John; Cope, Rick] ICX Nomad, Oklahoma City, OK USA. RP Smith, JP (reprint author), NIOSH, Biomonitoring Res Team, Biomonitoring & Hlth Assessment Branch, Cincinnati, OH 45226 USA. EM jps3@cdc.gov FU NIOSH and NIEHS [Y1-ES-0001] FX This work was supported in part by an interagency agreement between NIOSH and NIEHS (Y1-ES-0001-Clinical Immunotoxicity). NR 7 TC 7 Z9 7 U1 0 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1537-6524 J9 TOXICOL MECH METHOD JI Toxicol. Mech. Methods PY 2009 VL 19 IS 6-7 BP 416 EP 421 DI 10.1080/15376510903114959 PG 6 WC Toxicology SC Toxicology GA 502JW UT WOS:000270456100005 PM 19778242 ER PT J AU Wiegand, DM Hanowski, RJ McDonald, SE AF Wiegand, Douglas M. Hanowski, Richard J. McDonald, Shelby E. TI Commercial Drivers' Health: A Naturalistic Study of Body Mass Index, Fatigue, and Involvement in Safety-Critical Events SO TRAFFIC INJURY PREVENTION LA English DT Article DE Body mass index; Fatigue; Naturalistic methods; Commercial drivers; Safety-critical events; Health AB Objective: To explore the relation of commercial truck drivers' body mass indexex (BMI) to fatigued driving episodes and involvement in safety-critical events. Methods: One hundred and three professional truck drivers participated in a long-term naturalistic (on-road) driving study whereby vehicle motion data as well as video of the driver and driving environment were gathered continuously. This data set was analyzed to identify safety-critical events as well as fatigued driving episodes using two independent measures of fatigue. Odds ratio analyses were then performed to explore the relative risk of driving while fatigued and involvement in safety-critical events based on driver's BMI classification (obese versus non-obese). Results: Results indicated that of the 103 participating truck drivers, 53.4 percent were obese based on BMI. Odds ratio calculations revealed that obese individuals were between 1.22 (CI = 1.03-1.45) and 1.69 times (CI = 1.32-2.18) more likely than non-obese individuals to be rated as fatigued based on the two measures of fatigue. Other analyses showed that obese individuals were at 1.37 times (CI = 1.19-1.59) greater risk for involvement in a safety-critical event than non-obese individuals. Finally, one of the fatigue measures showed that obese individuals were 1.99 times (CI = 1.02-3.88) more likely than non-obese individuals to be fatigued while involved in an at-fault safety-critical incident. Conclusion: The results of this study support other research in the field of health and well-being that indicate a link between obesity and fatigue, which is a major safety issue surrounding commercial motor vehicle operations given the long hours these drivers spend on the road. C1 [Wiegand, Douglas M.] NIOSH, Cincinnati, OH 45226 USA. [Hanowski, Richard J.; McDonald, Shelby E.] Virginia Tech, Transportat Inst, Ctr Truck & Bus Safety, Blacksburg, VA USA. RP Wiegand, DM (reprint author), NIOSH, 4676 Columbia Pkwy R-10, Cincinnati, OH 45226 USA. EM dwiegand@cdc.gov OI McDonald, Shelby/0000-0001-6094-6234 FU National Surface Transportation Safety Center for Excellence (NSTSCE) FX The analyses described in this report were supported under the sponsorship of the National Surface Transportation Safety Center for Excellence (NSTSCE). The NSTSCE at VTTI was established by the Federal Public Transportation Act of 2005 to develop and disseminate advanced transportation safety techniques and innovations in both rural and urban communities. NR 23 TC 29 Z9 30 U1 0 U2 5 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1538-9588 J9 TRAFFIC INJ PREV JI Traffic Inj. Prev. PY 2009 VL 10 IS 6 BP 573 EP 579 AR PII 916865759 DI 10.1080/15389580903295277 PG 7 WC Public, Environmental & Occupational Health; Transportation SC Public, Environmental & Occupational Health; Transportation GA 525FS UT WOS:000272200500010 PM 19916128 ER PT J AU Kittikraisak, W Burapat, C Kaewsa-ard, S Watthanaamornkiet, W Sirinak, C Sattayawuthipong, W Jittimanee, S Pobkeeree, V Varma, JK AF Kittikraisak, Wanitchaya Burapat, Channawong Kaewsa-ard, Samroui Watthanaamornkiet, Wanpen Sirinak, Chawin Sattayawuthipong, Wanchai Jittimanee, Suksont Pobkeeree, Vallerut Varma, Jay K. TI Factors associated with tuberculosis treatment default among HIV-infected tuberculosis patients in Thailand SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article DE Tuberculosis; HIV; AIDS; Treatment default; Directly observed therapy; Thailand ID RISK-FACTORS; ANTIRETROVIRAL THERAPY; DEATH; INDIA AB Ensuring completion of tuberculosis (TB) treatment remains a major public health problem. In HIV-infected patients, TB is the most common severe opportunistic infection. Few studies have evaluated risk factors for TB treatment default in HIV-infected patients. We conducted a prospective, observational study of HIV-infected TB patients in Thailand. Patients underwent standardised evaluations at the beginning of TB treatment, at the end of the intensive phase and at the end of TB treatment. TB treatment outcomes were assessed according to WHO guidelines. The analysis was limited to patients who defaulted or who had treatment success. Of the 554 patients analysed, 61 (11%) defaulted. In multivariate analysis, factors associated with TB treatment default included incarceration history [adjusted odds ratio (AOR) 2.0, 95% CI 1.1-3.7), smoking (AOR 2.3, 95% CI 1.3-4.1) and having a symptom complaint score >15 (AOR 3.4, 95% CI 1.4-8.0); one marker of wealth, namely owning a refrigerator, was protective (AOR 0.4, 95% CI 0.2-0.8). Default during TB treatment was a significant problem in HIV-infected patients. Reducing default may require enhancing services for patients with a history of incarceration or smoking and designing patient-centred systems to address poverty and patient wellness. Published by Elsevier Ltd on behalf of Royal Society of Tropical Medicine and Hygiene. C1 [Kittikraisak, Wanitchaya; Burapat, Channawong; Varma, Jay K.] US Ctr Dis Control & Prevent Collaborat, Thailand Minist Publ Hlth, Nonthaburi, Thailand. [Kaewsa-ard, Samroui] Bamrasnaradura Infect Dis Inst, Nonthaburi, Thailand. [Watthanaamornkiet, Wanpen] Off Dis Prevent & Control 7, Ubon Ratchathani, Thailand. [Sirinak, Chawin] Bangkok Metropolitan Adm, Dept Hlth, Bangkok, Thailand. [Sattayawuthipong, Wanchai] Phuket Prov Hlth Off, Phuket, Thailand. [Varma, Jay K.] US Ctr Dis Control & Prevent, Atlanta, GA USA. RP Varma, JK (reprint author), US Embassy Beijing, CDC Sect, PSC 461,Box 50, FPO, AP 96521 USA. EM jvarma@cdc.gov FU US Agency for International Development FX This project was funded by the US Agency for International Development. The funding agency had no rote in study design, conduct, data analysis or manuscript preparation. NR 24 TC 11 Z9 13 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD JAN PY 2009 VL 103 IS 1 BP 59 EP 66 DI 10.1016/j.trstmh.2008.09.003 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 386YO UT WOS:000261918700011 PM 18937958 ER PT J AU Miller, CH AF Miller, Connie H. BE Hillyer, CD Shaz, BH Zimring, JC Abshire, TC TI Global Tests of Primary Hemostasis SO TRANSFUSION MEDICINE AND HEMOSTASIS: CLINICAL AND LABORATORY ASPECTS LA English DT Article; Book Chapter ID TIME C1 Ctr Dis Control & Prevent, Clin Hemostasis Lab, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Miller, CH (reprint author), Ctr Dis Control & Prevent, Clin Hemostasis Lab, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. OI Miller, Connie H/0000-0002-3989-7973 NR 3 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-0-08-092230-0 PY 2009 BP 615 EP 616 DI 10.1016/B978-0-12-374432-6.00115-9 PG 2 WC Hematology; Medical Laboratory Technology SC Hematology; Medical Laboratory Technology GA BCT50 UT WOS:000311357600116 ER PT J AU Miller, CH AF Miller, Connie H. BE Hillyer, CD Shaz, BH Zimring, JC Abshire, TC TI Platelet Aggregation Studies SO TRANSFUSION MEDICINE AND HEMOSTASIS: CLINICAL AND LABORATORY ASPECTS LA English DT Article; Book Chapter C1 Ctr Dis Control & Prevent, Clin Hemostasis Lab, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Miller, CH (reprint author), Ctr Dis Control & Prevent, Clin Hemostasis Lab, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. OI Miller, Connie H/0000-0002-3989-7973 NR 7 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-0-08-092230-0 PY 2009 BP 617 EP 621 DI 10.1016/B978-0-12-374432-6.00116-0 PG 5 WC Hematology; Medical Laboratory Technology SC Hematology; Medical Laboratory Technology GA BCT50 UT WOS:000311357600117 ER PT J AU Miller, CH AF Miller, Connie H. BE Hillyer, CD Shaz, BH Zimring, JC Abshire, TC TI Laboratory Diagnosis of Genetic Platelet Function Defects SO TRANSFUSION MEDICINE AND HEMOSTASIS: CLINICAL AND LABORATORY ASPECTS LA English DT Article; Book Chapter C1 Ctr Dis Control & Prevent, Clin Hemostasis Lab, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Miller, CH (reprint author), Ctr Dis Control & Prevent, Clin Hemostasis Lab, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. OI Miller, Connie H/0000-0002-3989-7973 NR 1 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-0-08-092230-0 PY 2009 BP 623 EP 626 DI 10.1016/B978-0-12-374432-6.00117-2 PG 4 WC Hematology; Medical Laboratory Technology SC Hematology; Medical Laboratory Technology GA BCT50 UT WOS:000311357600118 ER PT J AU Miller, CH AF Miller, Connie H. BE Hillyer, CD Shaz, BH Zimring, JC Abshire, TC TI Laboratory Diagnosis of Acquired Platelet Function Defects SO TRANSFUSION MEDICINE AND HEMOSTASIS: CLINICAL AND LABORATORY ASPECTS LA English DT Article; Book Chapter C1 Ctr Dis Control & Prevent, Clin Hemostasis Lab, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Miller, CH (reprint author), Ctr Dis Control & Prevent, Clin Hemostasis Lab, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. OI Miller, Connie H/0000-0002-3989-7973 NR 3 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-0-08-092230-0 PY 2009 BP 627 EP 629 DI 10.1016/B978-0-12-374432-6.00118-4 PG 3 WC Hematology; Medical Laboratory Technology SC Hematology; Medical Laboratory Technology GA BCT50 UT WOS:000311357600119 ER PT J AU Miller, CH AF Miller, Connie H. BE Hillyer, CD Shaz, BH Zimring, JC Abshire, TC TI Molecular Biology of von Willebrand Disease SO TRANSFUSION MEDICINE AND HEMOSTASIS: CLINICAL AND LABORATORY ASPECTS LA English DT Article; Book Chapter C1 Ctr Dis Control & Prevent, Clin Hemostasis Lab, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Miller, CH (reprint author), Ctr Dis Control & Prevent, Clin Hemostasis Lab, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. OI Miller, Connie H/0000-0002-3989-7973 NR 2 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-0-08-092230-0 PY 2009 BP 645 EP 647 DI 10.1016/B978-0-12-374432-6.00122-6 PG 3 WC Hematology; Medical Laboratory Technology SC Hematology; Medical Laboratory Technology GA BCT50 UT WOS:000311357600123 ER PT J AU Miller, CH AF Miller, Connie H. BE Hillyer, CD Shaz, BH Zimring, JC Abshire, TC TI Laboratory Diagnosis of Inherited von Willebrand Disease SO TRANSFUSION MEDICINE AND HEMOSTASIS: CLINICAL AND LABORATORY ASPECTS LA English DT Article; Book Chapter C1 Ctr Dis Control & Prevent, Clin Hemostasis Lab, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Miller, CH (reprint author), Ctr Dis Control & Prevent, Clin Hemostasis Lab, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. OI Miller, Connie H/0000-0002-3989-7973 NR 4 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-0-08-092230-0 PY 2009 BP 649 EP 652 DI 10.1016/B978-0-12-374432-6.00123-8 PG 4 WC Hematology; Medical Laboratory Technology SC Hematology; Medical Laboratory Technology GA BCT50 UT WOS:000311357600124 ER PT J AU Miller, CH AF Miller, Connie H. BE Hillyer, CD Shaz, BH Zimring, JC Abshire, TC TI Laboratory Diagnosis of Acquired von Willebrand Syndrome SO TRANSFUSION MEDICINE AND HEMOSTASIS: CLINICAL AND LABORATORY ASPECTS LA English DT Article; Book Chapter C1 Ctr Dis Control & Prevent, Clin Hemostasis Lab, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Miller, CH (reprint author), Ctr Dis Control & Prevent, Clin Hemostasis Lab, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. OI Miller, Connie H/0000-0002-3989-7973 NR 2 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-0-08-092230-0 PY 2009 BP 653 EP 654 DI 10.1016/B978-0-12-374432-6.00124-X PG 2 WC Hematology; Medical Laboratory Technology SC Hematology; Medical Laboratory Technology GA BCT50 UT WOS:000311357600125 ER PT J AU Miller, CH AF Miller, Connie H. BE Hillyer, CD Shaz, BH Zimring, JC Abshire, TC TI Laboratory Assessment of Treatment of von Willebrand Disease SO TRANSFUSION MEDICINE AND HEMOSTASIS: CLINICAL AND LABORATORY ASPECTS LA English DT Article; Book Chapter ID DIAGNOSIS C1 Ctr Dis Control & Prevent, Clin Hemostasis Lab, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Miller, CH (reprint author), Ctr Dis Control & Prevent, Clin Hemostasis Lab, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. OI Miller, Connie H/0000-0002-3989-7973 NR 4 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-0-08-092230-0 PY 2009 BP 655 EP 656 DI 10.1016/B978-0-12-374432-6.00125-1 PG 2 WC Hematology; Medical Laboratory Technology SC Hematology; Medical Laboratory Technology GA BCT50 UT WOS:000311357600126 ER PT J AU Miller, CH AF Miller, Connie H. BE Hillyer, CD Shaz, BH Zimring, JC Abshire, TC TI Coagulation Factor Testing SO TRANSFUSION MEDICINE AND HEMOSTASIS: CLINICAL AND LABORATORY ASPECTS LA English DT Article; Book Chapter ID HEMOSTATIC SYSTEM C1 Ctr Dis Control & Prevent, Clin Hemostasis Lab, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Miller, CH (reprint author), Ctr Dis Control & Prevent, Clin Hemostasis Lab, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. OI Miller, Connie H/0000-0002-3989-7973 NR 4 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-0-08-092230-0 PY 2009 BP 657 EP 660 DI 10.1016/B978-0-12-374432-6.00126-3 PG 4 WC Hematology; Medical Laboratory Technology SC Hematology; Medical Laboratory Technology GA BCT50 UT WOS:000311357600127 ER PT J AU Miller, CH AF Miller, Connie H. BE Hillyer, CD Shaz, BH Zimring, JC Abshire, TC TI Mixing Studies SO TRANSFUSION MEDICINE AND HEMOSTASIS: CLINICAL AND LABORATORY ASPECTS LA English DT Article; Book Chapter C1 Ctr Dis Control & Prevent, Clin Hemostasis Lab, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Miller, CH (reprint author), Ctr Dis Control & Prevent, Clin Hemostasis Lab, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. OI Miller, Connie H/0000-0002-3989-7973 NR 2 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-0-08-092230-0 PY 2009 BP 661 EP 662 DI 10.1016/B978-0-12-374432-6.00127-5 PG 2 WC Hematology; Medical Laboratory Technology SC Hematology; Medical Laboratory Technology GA BCT50 UT WOS:000311357600128 ER PT J AU Miller, CH AF Miller, Connie H. BE Hillyer, CD Shaz, BH Zimring, JC Abshire, TC TI Specific Factor Inhibitor Testing SO TRANSFUSION MEDICINE AND HEMOSTASIS: CLINICAL AND LABORATORY ASPECTS LA English DT Article; Book Chapter C1 Ctr Dis Control & Prevent, Clin Hemostasis Lab, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Miller, CH (reprint author), Ctr Dis Control & Prevent, Clin Hemostasis Lab, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. OI Miller, Connie H/0000-0002-3989-7973 NR 5 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-0-08-092230-0 PY 2009 BP 663 EP 665 DI 10.1016/B978-0-12-374432-6.00128-7 PG 3 WC Hematology; Medical Laboratory Technology SC Hematology; Medical Laboratory Technology GA BCT50 UT WOS:000311357600129 ER PT J AU Wallace, A Dietz, V Cairns, KL AF Wallace, A. Dietz, V. Cairns, K. L. TI Integration of immunization services with other health interventions in the developing world: what works and why? Systematic literature review SO TROPICAL MEDICINE & INTERNATIONAL HEALTH LA English DT Article DE immunization; vaccination; integration; review ID VITAMIN-A SUPPLEMENTATION; PLACEBO-CONTROLLED TRIAL; DISEASE-CONTROL PROGRAMS; EXPANDED PROGRAM; INTERMITTENT TREATMENT; DEVELOPING-COUNTRIES; TANZANIAN INFANTS; ANTIBODY-RESPONSE; RANDOMIZED-TRIAL; MALARIA VACCINE AB To assess benefits, challenges and characteristics of integrating child and maternal health services with immunization programmes. Literature review using journal databases and grey literature. Papers meeting the inclusion criteria were rated for the quality of methodology and relevant information was systematically abstracted. Integrated services were vitamin A supplementation, bednet distribution, deworming tablet distribution, Intermittent Preventive Therapy for infants and referrals for family planning services. Two key characteristics of success were compatibility between interventions and presence of a strong immunization service prior to integration. Overburdened staff, unequal resource allocation and logistical difficulties were mentioned as risks of integration, whereas rapid uptake of the linked intervention and less competition for resources were listed as two key benefits of integration. The theoretical strengths of integrating other health services with immunization services remain to be rigorously proved in practice. When additional interventions are carefully selected for compatibility and when they receive adequate support, coverage of these interventions may improve, provided immunization coverage is already high. Evidence for the effectiveness of integration in increasing efficiency of resource use was insufficient and most benefits and challenges were not statistically quantified. More substantive information about the costs of integrated vs. vertical programmes and full documentation of the impacts of integration on immunization services should be published. C1 [Wallace, A.; Dietz, V.; Cairns, K. L.] Ctr Dis Control & Prevent, Global Immunizat Div, Atlanta, GA USA. RP Wallace, A (reprint author), 1600 Clifton Rd MS-E05, Atlanta, GA 30333 USA. EM awallace@cdc.gov NR 33 TC 38 Z9 38 U1 0 U2 1 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1360-2276 J9 TROP MED INT HEALTH JI Trop. Med. Int. Health PD JAN PY 2009 VL 14 IS 1 BP 11 EP 19 DI 10.1111/j.1365-3156.2008.02196.x PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 395IN UT WOS:000262517900003 PM 19017307 ER PT J AU Feikin, DR Nguyen, LM Adazu, K Ombok, M Audi, A Slutsker, L Lindblade, KA AF Feikin, Daniel R. Nguyen, Ly Minh Adazu, Kubaje Ombok, Maurice Audi, Allan Slutsker, Laurence Lindblade, Kim A. TI The impact of distance of residence from a peripheral health facility on pediatric health utilisation in rural western Kenya SO TROPICAL MEDICINE & INTERNATIONAL HEALTH LA English DT Article DE health care utilisation; access to care; distance; Kenya ID MORTALITY; CHILDREN; MALARIA; ATTENDANCE; SERVICES; DISTRICT; FEVERS AB To explore the impact of distance on utilisation of peripheral health facilities for sick child visits in Asembo, rural western Kenya. As part of a demographic surveillance system (DSS), censuses of all households in the Asembo population of 55 000 are conducted three times a year, data are collected at all outpatient pediatric visits in seven DSS clinics in Asembo, and all households are GIS-mapped and linkable to a child's unique DSS identification number. Between May 1, 2003 and April 30, 2004, 3501 clinic visits were linked to 2432 children among 10 973 DSS-resident children < 5 years of age. Younger children and children with more severe illnesses travelled further for clinic visits. The median distance travelled varied by clinic. The rate of clinic visits decreased linearly at 0.5 km intervals up to 4 km, after which the rate stabilised. Using Poisson regression, controlling for the nearest DSS clinic for each child, socio-economic status and maternal education, and accounting for household clustering of children, for every 1 km increase in distance of residence from a DSS clinic, the rate of clinic visits decreased by 34% (95% CI, 31-37%) from the previous kilometer. Achieving equity in access to health care for children in rural Kenya will require creative strategies to address a significant distance-decay effect in health care utilisation. C1 [Feikin, Daniel R.; Nguyen, Ly Minh; Audi, Allan] Ctr Dis Control & Prevent, Internal Emerging Infect Program, Div Emerging Infect & Surveillance Serv,CDC, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA 30333 USA. [Feikin, Daniel R.; Adazu, Kubaje; Ombok, Maurice; Audi, Allan; Slutsker, Laurence; Lindblade, Kim A.] Kenya Govt Med Res Ctr, Kisumu, Kenya. [Slutsker, Laurence; Lindblade, Kim A.] CDC, Malaria Branch, Div Parasit Dis, Natl Ctr Zoonoses Vector Borne & Enter Dis, Atlanta, GA 30333 USA. RP Feikin, DR (reprint author), Ctr Dis Control & Prevent, Internal Emerging Infect Program, Div Emerging Infect & Surveillance Serv,CDC, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA 30333 USA. EM dfeikin@ke.cdc.gov NR 22 TC 61 Z9 61 U1 3 U2 12 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1360-2276 J9 TROP MED INT HEALTH JI Trop. Med. Int. Health PD JAN PY 2009 VL 14 IS 1 BP 54 EP 61 DI 10.1111/j.1365-3156.2008.02193.x PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 395IN UT WOS:000262517900008 PM 19021892 ER PT J AU Van Hemelrijck, MJJ Lindblade, KA Kubaje, A Hamel, MJ Odhiambo, F Phillips-Howard, PA Laserson, KF Slutsker, L Feikin, DR AF Van Hemelrijck, Mieke J. J. Lindblade, Kim A. Kubaje, Adazu Hamel, Mary J. Odhiambo, Frank Phillips-Howard, Penelope A. Laserson, Kayla F. Slutsker, Laurence Feikin, Daniel R. TI Trends observed during a decade of paediatric sick visits to peripheral health facilities in rural western Kenya, 1997-2006 SO TROPICAL MEDICINE & INTERNATIONAL HEALTH LA English DT Article DE sick child visit; surveillance; malaria; upper respiratory tract infection; Kenya ID TREATED BED NETS; PERENNIAL MALARIA TRANSMISSION; YOUNG-CHILDREN; INTEGRATED MANAGEMENT; CHILDHOOD ILLNESS; MORTALITY; TANZANIA; IMPACT; SURVEILLANCE; MORBIDITY AB To assess whether longitudinal surveillance in peripheral health facilities could document trends in disease burden, healthcare practice and utilization resulting from large-scale public health interventions made in the decade 1997-2006. Data were collected from sick child visits (SCVs) among children < 5 years attending 14 outpatient facilities in Asembo, rural western Kenya, during 1997-2006. Changes in proportions, and counts and rates were evaluated using chi-square and Poisson regression respectively. During the decade, 64 394 SCVs were made, yielding an average rate of 0.70 SCVs per child-year. The annual number of SCVs stayed constant during 1997-2003, then increased by 74% between 2003 and 2006 (P < 0.01). The time between symptom onset and SCV shortened from 5.6 days in 1997 to 4.4 days in 2006 (P < 0.01). Malaria and upper respiratory tract infection (URTI) were most commonly diagnosed (69% and 36% of SCVs respectively). Between 2003 and 2006, the proportion of SCVs with a malaria diagnosis fell from 77% to 48%, although the rate of malaria SCVs did not. URTI visits increased in 2004-2006. The most frequently prescribed antimalarials changed three times, lagging 1-2 years behind changes in national policy. Treatment of pneumonia with antibiotics varied by year, ranging from 19% to 89%. Surveillance of paediatric SCVs at peripheral health facilities was useful in documenting the timing and penetration of changes in national policies and clinical patterns of drug use for common infections. The surveillance data suggested that improved access to care, rather than disease burden changes, likely led to greater healthcare utilization after 2003. C1 [Van Hemelrijck, Mieke J. J.] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. [Lindblade, Kim A.; Kubaje, Adazu; Hamel, Mary J.; Odhiambo, Frank; Phillips-Howard, Penelope A.; Laserson, Kayla F.; Slutsker, Laurence; Feikin, Daniel R.] Kenya Govt Med Res Ctr, Kisumu, Kenya. [Lindblade, Kim A.; Hamel, Mary J.; Phillips-Howard, Penelope A.; Slutsker, Laurence] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis, Natl Ctr Zoonoses Vector Borne & Enter Dis,CDC, Atlanta, GA USA. [Laserson, Kayla F.] CDC, Coordinating Off Global Hlth, Atlanta, GA 30333 USA. [Feikin, Daniel R.] CDC, Natl Ctr Preparedness Detect & Control Infect Dis, Div Emerging Infect & Surveillance Serv, Int Emerging Infect Program, Atlanta, GA 30333 USA. RP Van Hemelrijck, MJJ (reprint author), Harvard Univ, Sch Publ Hlth, 665 Huntington Ave, Boston, MA 02115 USA. EM mvanheme@post.harvard.edu OI Phillips-Howard, Penelope A/0000-0003-1018-116X; Van Hemelrijck, Mieke/0000-0002-7317-0858 NR 23 TC 7 Z9 7 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1360-2276 J9 TROP MED INT HEALTH JI Trop. Med. Int. Health PD JAN PY 2009 VL 14 IS 1 BP 62 EP 69 DI 10.1111/j.1365-3156.2008.02184.x PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 395IN UT WOS:000262517900009 PM 19017311 ER PT J AU Lowther, SA Curriero, FC Shields, T Ahmed, S Monze, M Moss, WJ AF Lowther, Sara A. Curriero, Frank C. Shields, Timothy Ahmed, Saifuddin Monze, Mwaka Moss, William J. TI Feasibility of satellite image-based sampling for a health survey among urban townships of Lusaka, Zambia SO TROPICAL MEDICINE & INTERNATIONAL HEALTH LA English DT Article DE satellite imagery; geographic information systems; sampling; health survey; Zambia ID IMMUNIZATION COVERAGE AB To describe our experience using satellite image-based sampling to conduct a health survey of children in an urban area of Lusaka, Zambia, as an approach to sampling when the population is poorly characterized by existing census data or maps. Using a publicly available Quickbird (TM) image of several townships, we created digital records of structures within the residential urban study area using ArcGIS 9.2. Boundaries were drawn to create geographic subdivisions based on natural and man-made barriers (e.g. roads). Survey teams of biomedical research students and local community health workers followed a standard protocol to enrol children within the selected structure, or to move to the neighbouring structure if the selected structure was ineligible or refused enrolment. Spatial clustering was assessed using the K-difference function. Digital records of 16 105 structures within the study area were created. Of the 750 randomly selected structures, six (1%) were not found by the survey teams. A total of 1247 structures were assessed for eligibility, of which 691 eligible households were enroled. The majority of enroled households were the initially selected structures (51%) or the first selected neighbour (42%). Households that refused enrolment tended to cluster more than those which enroled. Sampling from a satellite image was feasible in this urban African setting. Satellite images may be useful for public health surveillance in populations with inaccurate census data or maps and allow for spatial analyses such as identification of clustering among refusing households. C1 [Lowther, Sara A.; Moss, William J.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. [Curriero, Frank C.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD USA. [Curriero, Frank C.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD USA. [Shields, Timothy; Moss, William J.] Johns Hopkins Bloomberg Sch Publ Hlth, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD USA. [Ahmed, Saifuddin] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Populat Family & Reprod Hlth, Baltimore, MD USA. [Monze, Mwaka] Univ Teaching Hosp, Virol Lab, Lusaka, Zambia. RP Lowther, SA (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv Assigned Minnesota, Dept Hlth, Atlanta, GA 30333 USA. EM SGL6@cdc.gov FU Thrasher Research Fund [02818-9]; National Eye Institute Training Grant [EY 07127]; Clinical Trials Training Program in Vision Research; National Institutes of Health; Department of Health and Human Services FX This work was supported by a grant from the Thrasher Research Fund (02818-9) to W.J.M. S.A.L was supported by the National Eye Institute Training Grant (EY 07127), pre-doctoral Clinical Trials Training Program in Vision Research, National Institutes of Health, Department of Health and Human Services. We thank Dr Greg Glass for his expertise and support. We thank Mr. Peter Musonda, Ms Chansa Mawonde and Mr David Muonde for their logistical expertise in conducting the survey. We thank the Tianjane Community Theater Group for their creative and motivational performances as part of the community sensitization activities. NR 18 TC 9 Z9 9 U1 0 U2 3 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1360-2276 J9 TROP MED INT HEALTH JI Trop. Med. Int. Health PD JAN PY 2009 VL 14 IS 1 BP 70 EP 78 DI 10.1111/j.1365-3156.2008.02185.x PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 395IN UT WOS:000262517900010 PM 19121149 ER PT J AU Powers, AM Brault, AC AF Powers, Ann M. Brault, Aaron C. BE Barrett, ADT Stanberry, LR TI O'nyong-nyong and Chikungunya SO VACCINES FOR BIODEFENSE AND EMERGING AND NEGLECTED DISEASES LA English DT Article; Book Chapter ID ROSS-RIVER-VIRUS; ARTHROPOD-BORNE VIRUSES; AEDES-AEGYPTI MOSQUITOS; SEMLIKI-FOREST-VIRUS; SOUTH-CENTRAL UGANDA; IGBO-ORA VIRUS; ANTIBODY-DEPENDENT ENHANCEMENT; STRAND RNA-SYNTHESIS; SINDBIS VIRUS; IN-VITRO AB At the individual level, vaccines have the potential to modulate the severity of illness as well as eliminate or reduce the likelihood of transmission of the pathogen to others making vaccination one of the most effective disease intervention tools available. Several vaccines against arthropod-borne viruses (arboviruses), including yellow fever virus and Japanese encephalitis virus, have been developed and are in widespread use. As there are approximately 600 known arboviruses, many of which cause severe human disease, additional vaccine development is warranted. Among the arboviruses pathogenic to humans are chikungunya (CHIKV) and o'nyong-nyong (ONNV) viruses. These viruses cause explosive outbreaks and induce a prolonged, debilitating arthralgic illness that can have a dramatic impact on the affected communities. "Despite these facts, there are no therapeutics or vaccines commercially available for either virus". Preliminary vaccine development and characterization has been initiated for CHIKV leading to Phase 2 human clinical trials. Results from these studies have been promising to date. Unfortunately, the marketability of a vaccine against this virus is uncertain thus limiting the rapid development of a commercial product. As epidemics of illness caused by both CHIKV and ONNV continue to occur with greater intensity and frequency, the possibility of producing a vaccine for widespread distribution may also be more likely. This chapter describes the biology, ecology, and epidemiology of these viruses providing a framework from which to propose and support alphavirus vaccine development. C1 [Powers, Ann M.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO USA. [Brault, Aaron C.] Univ Calif Davis, Dept Pathol & Microbiol, Ctr Vector Borne Dis, Sch Vet Med, Davis, CA 95616 USA. [Brault, Aaron C.] Univ Calif Davis, Dept Immunol, Ctr Vector Borne Dis, Sch Vet Med, Davis, CA 95616 USA. RP Powers, AM (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Rampart Rd, Ft Collins, CO USA. NR 189 TC 0 Z9 0 U1 0 U2 2 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA BN 978-0-08-091902-7 PY 2009 BP 589 EP 607 DI 10.1016/B978-0-12-369408-9.00032-9 PG 19 WC Public, Environmental & Occupational Health; Immunology; Infectious Diseases SC Public, Environmental & Occupational Health; Immunology; Infectious Diseases GA BCR60 UT WOS:000311106000034 ER PT J AU Fooks, AR Johnson, N Rupprecht, CE AF Fooks, Anthony R. Johnson, Nicholas Rupprecht, Charles E. BE Barrett, ADT Stanberry, LR TI Rabies SO VACCINES FOR BIODEFENSE AND EMERGING AND NEGLECTED DISEASES LA English DT Article; Book Chapter ID CENTRAL-NERVOUS-SYSTEM; VIRUS-NEUTRALIZING EPITOPE; MOLECULAR EPIDEMIOLOGY; IMMUNE-RESPONSES; UNITED-STATES; BAT LYSSAVIRUSES; PHYLOGENETIC-RELATIONSHIPS; POSTEXPOSURE PROPHYLAXIS; ACETYLCHOLINE-RECEPTOR; INTERFERON-PRODUCTION AB Rabies is unique among the viral diseases of man in that it kills virtually every individual it infects. The illness associated with the disease, in previous times referred to as hydrophobia, is particularly unpleasant for the victim but also for health care workers and relatives who have to witness it. Global estimates of death from rabies suggest that one person dies from the disease every 10 min, and more than 300 others are exposed. This claim is supported by a study of Malawian children with viral encephalitis, where 3 (11.5%) of 26 children originally clinically diagnosed with cerebral malaria were later laboratory-confirmed as having rabies suggesting that human disease is underreported in some rabies-endemic countries. The disease is distributed worldwide and is endemic in many countries causing an estimated 50,000-70,000 human deaths each year, although the true burden of the disease is unknown due to underreporting and poor surveillance systems in many areas of the world (Meltzer and Rupprecht, 1998; Fooks, 2005). Following exposure, the virus invades the peripheral nervous system before entering the CNS leading to malfunction, organ failure, and ultimately death. Two clinical manifestations, "furious" and "dumb" (paralytic) rabies are observed following infection although the mechanisms of both syndromes are still not well understood. Rabies virus belongs to the Lyssavirus genus, which contains seven recognized genotypes. The genus can be divided into two broad groups or phylogroups. Genotype 1 ("classical" rabies virus), 4, 5, 6, and 7 belong to phylogroup I, while genotypes 2 and 3 have been placed in phylogroup II on the basis of glycoprotein sequence, pathogenicity, and immunogenicity. Additionally, there are four newly described lyssavirus species: Aravan, Khujand, Irkut, and West Caucasian Bat Virus that have been recently isolated from bats in Eurasia. All lyssaviruses are capable of causing clinical "rabies" in mammals. Throughout the world, greater than 10 million people, many of whom are unvaccinated, have to endure extreme anxiety of "suspect" rabies following exposure from a rabid animal. Although preexposure vaccination and postexposure prophylaxis (PEP) for rabies is highly effective, ignorance about the disease, especially in developing countries, impedes timely intervention. In rare circumstances, vaccine failures have been reported. Highly effective vaccines have been developed for both animal and human use that induce long-term immunity against virus challenge; however the rabies virus vaccines were derived from isolates obtained between 50 and 100 years ago. Such strains are unlikely to take into account the genetic variation of the virus in the field accompanying the spatiotemporal fluctuation of reservoir species. Current evidence suggests that human vaccines, based on inactivated rabies virus, are not fully protective against all of the lyssavirus genotypes. The ease of obtaining live virus from an animal reservoir is straightforward although propagating the virus requires specific skills and specialist laboratory facilities. Rabies virus is poorly transmitted by the airborne route, but does present a substantial hazard to personnel exposed to aerosols of rabies virus. The virus is unlikely to be an effective bioweapon if the aim of any terrorist act is to achieve rapid dissemination of the agent with maximum human exposure, largely due to the unpredictability of transmission and long incubation periods. However, the ability of the disease to provoke fear makes the virus a biothreat agent that could result in considerable public concern if deliberately reintroduced into a rabies-free region, i.e., Western Europe. In addition, governments confronted with a deliberate reintroduction would be obliged to instigate costly elimination strategies, protection of domestic livestock, and public information programs suggesting that the virus could be used as a means of "agroterroism." As a result the virus is classified as a "category C emerging infectious disease threat." Future candidate vaccines need to be designed with broad-spectrum activity against all lyssaviruses, and ease of delivery using either oral or parenteral routes focusing on the creation of herd immunity among species. Furthermore, they must elicit long-term immunity, inducing both adaptive and innate immunity in a single-dose and produced at a cost that will allow widespread use throughout the world but especially in developing countries where rabies is still endemic. No antiviral agents are effective against the rabies virus and there is an urgent need for biologicals that inhibit the virus and provide relief from this devastating disease. C1 [Fooks, Anthony R.; Johnson, Nicholas] Vet Labs Agcy Weybridge, Rabies & Wildlife Zoonoses Grp, Addlestone, Surrey, England. [Rupprecht, Charles E.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Fooks, AR (reprint author), Vet Labs Agcy Weybridge, Rabies & Wildlife Zoonoses Grp, Addlestone, Surrey, England. NR 156 TC 4 Z9 4 U1 0 U2 8 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA BN 978-0-08-091902-7 PY 2009 BP 609 EP 630 DI 10.1016/B978-0-12-369408-9.00033-0 PG 22 WC Public, Environmental & Occupational Health; Immunology; Infectious Diseases SC Public, Environmental & Occupational Health; Immunology; Infectious Diseases GA BCR60 UT WOS:000311106000035 ER PT J AU Roehrig, JT AF Roehrig, John T. BE Barrett, ADT Stanberry, LR TI West Nile SO VACCINES FOR BIODEFENSE AND EMERGING AND NEGLECTED DISEASES LA English DT Article; Book Chapter ID BORNE ENCEPHALITIS-VIRUS; YELLOW-FEVER VIRUS; NONSTRUCTURAL PROTEIN NS1; HUMAN DENDRITIC CELLS; T-LYMPHOCYTE CLONES; HUMANIZED MONOCLONAL-ANTIBODY; MICROSPHERE-BASED IMMUNOASSAY; IMMUNOGLOBULIN-M ANTIBODIES; CROWS CORVUS-OSSIFRAGUS; VIREMIC BLOOD-DONORS AB West Nile virus (WNV) is an emerging flavivirus throughout the western hemisphere. Originally isolated in Africa in 1937, WNV jumped continents, first to Europe, and later to North America in 1999. Since its original discovery in the New York City area in 1999, WNV has been on an inexorable march west and south through North, Central, and South America, demonstrating a 20% human morbidity rate and a 30% equine case-fatality rate. By the end of 2007, there have been over 27,000 human cases of WNV with 1086 human case fatalities in the United States alone. The unexpected introduction of WNV into the United States continues to serve as an excellent example of the effects an emerging infectious disease can have on the public health infrastructure of a country, and the subsequent steps taken to track, prevent, and control such events. C1 US PHS, Arboviral Dis Branch, Div Vector Borne Infect Dis, Ctr Dis Control & Prevent,Dept Hlth & Human Serv, Ft Collins, CO USA. RP Roehrig, JT (reprint author), US PHS, Arboviral Dis Branch, Div Vector Borne Infect Dis, Ctr Dis Control & Prevent,Dept Hlth & Human Serv, Ft Collins, CO USA. NR 195 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA BN 978-0-08-091902-7 PY 2009 BP 735 EP 751 DI 10.1016/B978-0-12-369408-9.00039-1 PG 17 WC Public, Environmental & Occupational Health; Immunology; Infectious Diseases SC Public, Environmental & Occupational Health; Immunology; Infectious Diseases GA BCR60 UT WOS:000311106000041 ER PT S AU Fiore, AE Bridges, CB Cox, NJ AF Fiore, Anthony E. Bridges, Carolyn B. Cox, Nancy J. BE Compans, RW Orenstein, WA TI Seasonal Influenza Vaccines SO VACCINES FOR PANDEMIC INFLUENZA SE Current Topics in Microbiology and Immunology LA English DT Article; Book Chapter ID GUILLAIN-BARRE-SYNDROME; RANDOMIZED CONTROLLED-TRIAL; HEALTH-CARE WORKERS; A H3N2 EPIDEMIC; VACCINATING JAPANESE SCHOOLCHILDREN; HUMAN-IMMUNODEFICIENCY-VIRUS; NURSING-HOME RESIDENTS; ACUTE OTITIS-MEDIA; LONG-TERM-CARE; ANTIGENICALLY DRIFTED INFLUENZA AB Influenza vaccines are the mainstay of efforts to reduce the substantial health burden from seasonal influenza. Inactivated influenza vaccines have been available since the 1940s and are administered via intramuscular injection. Inactivated vaccines can be given to anyone six months of age or older. Live attenuated, cold-adapted influenza vaccines (LAIV) were developed in the 1960s but were not licensed in the United States until 2003, and are administered via nasal spray. Both vaccines are trivalent preparations grown in eggs and do not contain adjuvants. LAW is licensed for use in the United States for healthy nonpregnant persons 2-49 years of age. C1 [Fiore, Anthony E.; Bridges, Carolyn B.; Cox, Nancy J.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Cox, NJ (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE, Atlanta, GA 30333 USA. NR 255 TC 105 Z9 106 U1 0 U2 10 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0070-217X BN 978-3-540-92164-6 J9 CURR TOP MICROBIOL JI Curr.Top.Microbiol.Immunol. PY 2009 VL 333 BP 43 EP 82 DI 10.1007/978-3-540-92165-3_3 D2 10.1007/978-3-540-92165-3 PG 40 WC Biotechnology & Applied Microbiology; Immunology; Microbiology SC Biotechnology & Applied Microbiology; Immunology; Microbiology GA BKY26 UT WOS:000269608300003 PM 19768400 ER PT S AU O'Neill, E Donis, RO AF O'Neill, Eduardo Donis, Ruben O. BE Compans, RW Orenstein, WA TI Generation and Characterization of Candidate Vaccine Viruses for Prepandemic Influenza Vaccines SO VACCINES FOR PANDEMIC INFLUENZA SE Current Topics in Microbiology and Immunology LA English DT Article; Book Chapter ID A/VIETNAM/1194/2004 H5N1 VACCINE; RECEPTOR-BINDING SPECIFICITY; AVIAN INFLUENZA; A VIRUS; PANDEMIC INFLUENZA; SOUTHEASTERN CHINA; REVERSE GENETICS; SOUTHERN CHINA; UNITED-STATES; HONG-KONG AB Vaccination will be a critical public health intervention to mitigate the next influenza pandemic. Its effectiveness will depend on preparedness at multiple levels, from the laboratory bench to the population. Here we describe a global approach to ensure that appropriate candidate vaccine viruses are produced, evaluated, and made available to vaccine manufacturers in a timely fashion. This is an integrated activity involving global virologic and epidemiologic surveillance, genetic and antigenic characterization of influenza viruses, pandemic risk assessments, selection of appropriate virus strains for vaccines, production of reassortant viruses by reverse genetics, and finally, analysis of their safety and growth characteristics prior to distribution. These procedures must comply with national and international regulations governing vaccine and environmental safety. C1 [O'Neill, Eduardo; Donis, Ruben O.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Coordinating Ctr Infect Dis, Atlanta, GA 30333 USA. RP Donis, RO (reprint author), Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Coordinating Ctr Infect Dis, 1600 Clifton Rd,Mail Stop G-16, Atlanta, GA 30333 USA. EM eoneill@cdc.gov; rdonis@cdc.gov NR 142 TC 17 Z9 17 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0070-217X BN 978-3-540-92164-6 J9 CURR TOP MICROBIOL JI Curr.Top.Microbiol.Immunol. PY 2009 VL 333 BP 83 EP 108 DI 10.1007/978-3-540-92165-3_4 D2 10.1007/978-3-540-92165-3 PG 26 WC Biotechnology & Applied Microbiology; Immunology; Microbiology SC Biotechnology & Applied Microbiology; Immunology; Microbiology GA BKY26 UT WOS:000269608300004 PM 19768401 ER PT S AU Sambhara, S McElhaney, JE AF Sambhara, Suryaprakash McElhaney, Janet E. BE Compans, RW Orenstein, WA TI Immunosenescence and Influenza Vaccine Efficacy SO VACCINES FOR PANDEMIC INFLUENZA SE Current Topics in Microbiology and Immunology LA English DT Article; Book Chapter ID T-CELL RESPONSES; HUMAN MONOCLONAL-ANTIBODIES; RANDOMIZED CONTROLLED-TRIAL; HEALTHY ELDERLY POPULATION; AGE-RELATED-CHANGES; MEMORY B-CELLS; INNATE IMMUNITY; HEMATOPOIETIC STEM; UNITED-STATES; RNA HELICASE AB A number of protective immune functions decline with age along with physiological and anatomical changes, contributing to the increased susceptibility of older adults to infectious diseases and suboptimal protective immune responses to vaccination. Influenza vaccination is the most cost-effective strategy to prevent complications from influenza viral infections; however, the immunogenicity and effectiveness of currently licensed vaccines in the United States is about 30-50% in preventing complications arising from influenza and preventing death from all causes during winter months in older adults. Hence, it is crucial to understand the molecular mechanisms that lead to immune dysfunction as a function of age so that appropriate strategies can be developed to enhance the disease resistance and immunogenicity of preventive vaccines, including influenza vaccines, for the older adult population. C1 [Sambhara, Suryaprakash] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA. [McElhaney, Janet E.] Univ British Columbia, Dept Med, Vancouver, BC V6Y 1Y6, Canada. RP Sambhara, S (reprint author), Ctr Dis Control & Prevent, Influenza Div, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM ssambhara@cdc.gov; JMcElhaney@providencehealth.bc.ca NR 109 TC 49 Z9 51 U1 0 U2 3 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0070-217X BN 978-3-540-92164-6 J9 CURR TOP MICROBIOL JI Curr.Top.Microbiol.Immunol. PY 2009 VL 333 BP 413 EP 429 DI 10.1007/978-3-540-92165-3_20 D2 10.1007/978-3-540-92165-3 PG 17 WC Biotechnology & Applied Microbiology; Immunology; Microbiology SC Biotechnology & Applied Microbiology; Immunology; Microbiology GA BKY26 UT WOS:000269608300020 PM 19768417 ER PT S AU Schwartz, B Orenstein, WA AF Schwartz, Benjamin Orenstein, Walter A. BE Compans, RW Orenstein, WA TI Prioritization of Pandemic Influenza Vaccine: Rationale and Strategy for Decision Making SO VACCINES FOR PANDEMIC INFLUENZA SE Current Topics in Microbiology and Immunology LA English DT Article; Book Chapter ID MASS VACCINATION; H5N1 VACCINE; IMMUNOGENICITY; EPIDEMIC; IMMUNITY; SAFETY; TRIAL C1 [Schwartz, Benjamin] Ctr Dis Control & Prevent, Natl Vaccine Program Off, US Dept HHS, Atlanta, GA 30333 USA. [Orenstein, Walter A.] Emory Univ, Sch Med, Dept Med, Atlanta, GA 30322 USA. [Orenstein, Walter A.] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA. RP Schwartz, B (reprint author), Ctr Dis Control & Prevent, Natl Vaccine Program Off, US Dept HHS, 1600 Clifton Rd NE,Mailstop E-05, Atlanta, GA 30333 USA. EM bxs1@cdc.gov; walter.orenstein@gatesfoundation.org; walter.orenstein@gatesfoundation.org NR 21 TC 8 Z9 8 U1 0 U2 1 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0070-217X BN 978-3-540-92164-6 J9 CURR TOP MICROBIOL JI Curr.Top.Microbiol.Immunol. PY 2009 VL 333 BP 495 EP 507 DI 10.1007/978-3-540-92165-3_24 D2 10.1007/978-3-540-92165-3 PG 13 WC Biotechnology & Applied Microbiology; Immunology; Microbiology SC Biotechnology & Applied Microbiology; Immunology; Microbiology GA BKY26 UT WOS:000269608300024 PM 19768421 ER PT J AU Bhatnagar, V Frosch, DL Tally, SR Hamori, CJ Lenert, L Kaplan, RM AF Bhatnagar, Vibha Frosch, Dominick L. Tally, Steven R. Hamori, Charles J. Lenert, Leslie Kaplan, Robert M. TI Evaluation of an Internet-Based Disease Trajectory Decision Tool for Prostate Cancer Screening SO VALUE IN HEALTH LA English DT Article DE decision aids; patient preferences; prostate cancer; prostate cancer screening; utility weights ID QUALITY-OF-LIFE; EXTERNAL-BEAM RADIATION; RADICAL PROSTATECTOMY; RANDOMIZED-TRIAL; TREATMENT PREFERENCES; DEFERRED TREATMENT; TREATMENT OPTIONS; ANTIGEN; CARCINOMA; OUTCOMES AB To evaluate the application of a chronic disease model (CDM) for prostate cancer to visual analog scale (VAS) and time trade-off (TTO) decision tools. A total of 138 men (mean age 58 years) viewed a CDM module for prostate cancer with and without prostate specific antigen (PSA) screening. Participants rated their hypothetical quality of life with potential prostate cancer treatment complications using a CDM-based VAS decision tool. They were then asked to estimate how many years they would be willing to trade to be free of treatment complications using a CDM-based TTO decision tool. The consistency between VAS and TTO scores and the relationship between scores and preferences for PSA screening test and hypothetical treatment choice for prostate cancer were then evaluated. There was a significant relationship between the VAS and TTO ratings (regression P < 0.001). The TTO tool was sensitive to age. Mean scores with standard deviations for those less than 58 years compared to those 58 years and more were 7.78 (1.75) and 8.41 (1.52), respectively (P = 0.04). Using the VAS tool, men who chose PSA screening had higher quality of life ratings compared to men who did not choose PSA screening: 7.73 (1.78) and 6.59 (2.39), respectively (P = 0.01). Similar results were found with the TTO decision tool: 8.33 (1.45) and 7.04 (2.00), respectively (P = 0.005). Men who would hypothetically prefer treatment for moderately differentiated prostate cancer also had higher TTO scores compared to men who preferred watchful waiting: 8.54 (1.39) and 7.85 (1.73), respectively (P = 0.04). CDM-based for prostate cancer, VAS and TTO ratings were consistent and were concordant with patient preferences for screening; TTO ratings were also concordant with treatment choice. The use of the CDM-based TTO ratings to adjust for quality of life in decision analytic modeling needs to be explored. C1 [Bhatnagar, Vibha] Univ Calif San Diego, VA Med Ctr San Diego, Dept Family & Prevent Med, Sch Med, San Diego, CA 92131 USA. [Bhatnagar, Vibha] Dept Vet Affairs, Hlth Serv Res & Dev, San Diego, CA USA. [Frosch, Dominick L.] Univ Calif Los Angeles, Dept Med, Div Gen Internal Med, Los Angeles, CA 90024 USA. [Frosch, Dominick L.] Univ Calif Los Angeles, Hlth Serv Res, Los Angeles, CA 90024 USA. [Hamori, Charles J.] Kaiser Permanente, Dept Prevent Med, San Diego, CA USA. [Lenert, Leslie] Ctr Dis Control, Natl Ctr Hlth Informat, Atlanta, GA 30333 USA. [Kaplan, Robert M.] Univ Calif Los Angeles, Sch Publ Hlth, Dept Hlth Serv, Los Angeles, CA 90024 USA. RP Bhatnagar, V (reprint author), Univ Calif San Diego, VA Med Ctr San Diego, Dept Family & Prevent Med, Sch Med, 3350 La Jolla Village Dr,111N-1, San Diego, CA 92131 USA. EM vbhatnag@ucsd.edu FU CDC, Department for Veterans Affairs [U57/CCU920678-04-1] FX Source of financial support: CDC U57/CCU920678-04-1, Department for Veterans Affairs. NR 59 TC 4 Z9 4 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1098-3015 J9 VALUE HEALTH JI Value Health PD JAN-FEB PY 2009 VL 12 IS 1 BP 101 EP 108 DI 10.1111/j.1524-4733.2008.00407.x PG 8 WC Economics; Health Care Sciences & Services; Health Policy & Services SC Business & Economics; Health Care Sciences & Services GA 397XX UT WOS:000262696800016 PM 18637139 ER PT J AU Thoen, CO Lobue, PA Enarson, DA Kaneene, JB de Kantor, IN AF Thoen, Charles O. LoBue, Philip A. Enarson, Donald A. Kaneene, John B. de Kantor, Isabel N. TI Tuberculosis: a re-emerging disease in animals and humans SO VETERINARIA ITALIANA LA English DT Review DE Health; Mycobacterium; Mycobacterium bovis; Mycobacterium tuberculosis; One Health; Public health; Tuberculosis ID MYCOBACTERIUM-BOVIS INFECTION; KRUGER-NATIONAL-PARK; WHITE-TAILED DEER; MULTIDRUG-RESISTANT TUBERCULOSIS; IMMUNODEFICIENCY-VIRUS-INFECTION; FERRETS MUSTELA-FURO; SAN-DIEGO COUNTY; HEDGEHOGS ERINACEUS-EUROPAEUS; LENGTH-POLYMORPHISM ANALYSIS; POLYMERASE-CHAIN-REACTION AB Tuberculosis continues to be an important disease both in humans and animals. It causes morbidity, mortality and economic loss worldwide. The occurrence of Mycobacterium bovis disease in human,.;, domesticated and wild animals confirms the relevance of this zoonosis. M. bovis in humans continues to be reported in industrialised countries and in immigrants from regions of the world where tuberculosis in cattle is endemic. The real incidence of M. bovis in humans in developing countries continues to be roughly underestimated due to the scarcity of appropriate laboratory facilities to isolate and to differentiate M. bovis strains. In Latin America, less than 1% of tuberculosis cases are reported as being due to M. bovis. However, the economic relevance that meat and dairy industries play in these Countries stimulates the promotion of bovine tuberculosis eradication programmes. Human-to-human airborne transmission of M. bovis does occur and it may be important where human immunodeficiency virus (HIV) infection in humans is prevalent, M. bovis infection in cattle is enzootic and pasteurisation of dairy products is not routinely practised. Eradication of M. bovis in cattle and pasteurisation of dairy products are the cornerstones of prevention of human disease. Measures should be developed to identify and control M. bovis infection in wild animals as these may be important reservoirs of infection for domesticated food-producing animals. There is a need for medical and veterinary professionals to cooperate on disease Outbreaks. The information presented herein strongly Supports the 'One World/One Health/one Medicine' concept. C1 [Thoen, Charles O.] Iowa State Univ, Coll Vet Med, Dept Vet Microbiol & Prevent Med, Ames, IA 50011 USA. [LoBue, Philip A.] Ctr Dis Control & Prevent, TB Eliminat Div, Med Consultat Team, Atlanta, GA 30333 USA. [Enarson, Donald A.] Int Union TB & Lung Dis, F-75006 Paris, France. [Kaneene, John B.] Michigan State Univ, Coll Vet Med, Ctr Comparat Epidemiol, E Lansing, MI 48824 USA. [de Kantor, Isabel N.] WHO, RA-1429 Buenos Aires, DF, Argentina. RP Thoen, CO (reprint author), Iowa State Univ, Coll Vet Med, Dept Vet Microbiol & Prevent Med, Ames, IA 50011 USA. EM cthoen@iastate.edu NR 287 TC 39 Z9 41 U1 2 U2 18 PU IST ZOOPROFILATTICO SPERIMENTALE ABRUZZO & MOLISE G CAPORALE-IZS A&M PI TERAMO PA CAMPO BOARIO, TERAMO, 64100, ITALY SN 0505-401X J9 VET ITAL JI Vet. Ital. PD JAN-MAR PY 2009 VL 45 IS 1 BP 135 EP 181 PG 47 WC Veterinary Sciences SC Veterinary Sciences GA 476JQ UT WOS:000268436700012 PM 20391396 ER PT J AU Williams, CM Brett, KM Abma, JC AF Williams, Corrine M. Brett, Kate M. Abma, Joyce C. TI Coercive First Intercourse and Unintended First Births SO VIOLENCE AND VICTIMS LA English DT Article DE unwanted pregnancy; reproductive behavior; sexual violence; rape AB Since research has shown that victims of violence are more likely to be involved in subsequent risky sexual behaviors, we hypothesized that coercive first intercourse would be associated with unintended first births. Using nationally representative data from the 2002 National Survey of Family Growth, we analyzed female respondents aged 18-44 years who reported a live birth (n = 4,136). Coercion was classified as none/minimal, mild, or significant based on self-report. In 2002, 13.7% of U. S. women aged 18-44 who had at least one live birth experienced mild coercion and 9.8% experienced significant coercion at first intercourse. Compared with women who experienced no coercion, the odds of reporting an unintended first birth was greater for women who experienced mild (OR: 1.9, 95% CI: 1.4-2.6) or significant coercion (OR: 2.3, 95% CI: 1.6-3.4). C1 [Williams, Corrine M.; Brett, Kate M.; Abma, Joyce C.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Williams, CM (reprint author), Univ Kentucky, Chandler Hosp C 347, Dept Obstet & Gynecol, 800 Rose St, Lexington, KY 40536 USA. EM corrine.williams@uky.edu NR 26 TC 4 Z9 4 U1 1 U2 1 PU SPRINGER PUBLISHING CO PI NEW YORK PA 11 WEST 42ND STREET, NEW YORK, NY 10036 USA SN 0886-6708 J9 VIOLENCE VICTIMS JI Violence Vict. PY 2009 VL 24 IS 3 BP 351 EP 363 DI 10.1891/0886-6708.24.3.351 PG 13 WC Criminology & Penology SC Criminology & Penology GA V18EU UT WOS:000207988900005 PM 19634361 ER PT B AU Kuno, G Chang, GJJ Chien, LJ AF Kuno, Goro Chang, Gwong-Jen J. Chien, Li-Jung BE Feng, Z Long, M TI Correlations of Phylogenetic Relation with Host Range, Length of ORF or Genes, Organization of Conserved Sequences in the 3 ' Noncoding Region, and Viral Classification among the Members of the Genus Flavivirus SO VIRAL GENOMES: DIVERSITY, PROPERTIES AND PARAMETERS LA English DT Article; Book Chapter ID YELLOW-FEVER VIRUS; TICK-BORNE FLAVIVIRUS; ANTIGENIC RELATIONSHIPS; NUCLEOTIDE-SEQUENCE; SIZE HETEROGENEITY; ENCEPHALITIS-VIRUS; INSECT FLAVIVIRUS; EVOLUTION; ADAPTATION; TRANSMISSION AB The genus Flavivirus of the family Flaviviridae is a diverse group of RNA viruses comprising more than 60 viruses, including many medically important viruses such as yellow fever virus, dengue virus, and West Nile virus. The members of the genus are phylogenetically and biologically classified into four subgroups, each with a clear demarcation of host range, including insects, vertebrates, and two vector-borne subgroups transmitted between vertebrates and ticks or between vertebrates and mosquitoes. Thus, this group is ideal for determining the history of and the mechanisms involved in adaptation of animal RNA viruses to two disparate phyla of hosts. In the past, in the absence of fossil records, evolutionary studies of nearly all RNA viruses have relied only on phylogenetic inference based on sequences of a limited number of genes. Ideally, in addition to phylogenetic inference based on sequence data, holistic approaches incorporating multiple viral traits including other useful genomic and phenotypic traits should be used to determine the evolutionary history of the viruses. Flaviviruses are exceptionally suitable for such studies because of distinct host range among subgroups within one genus. This phenotypic expression provides a unique opportunity to investigate the correlations among full-length genome sequence, other genomic and organizational traits, phylogenetic relationship, host range shift, and taxonomic relation. The recent rapid increase in the number of flaviviruses with known full-genome sequence and other recent progress in sequence analyses of flaviviruses representing the four subgroups, as well as in vitro host range study, made it possible to undertake a holistic approach for the study of these viruses. Our most recent studies presented in this article reveal that open reading frame (ORF) length range increased in the four subgroups, exactly correlating to the branching order depicted in the NS5 gene tree. Furthermore, an incremental increase in the length range of several genes, increasing trend of the complexity of conserved sequence organization in the 3' noncoding region, and host range specificity, are, in combination, more compatible with the branching order illustrated in the phylogeny based on the NS5 gene than with the phylogeny based on the NS3 gene or ORE Also, host range specificities based on in vitro laboratory tests correlate very well with the data based on field observations and in vivo laboratory experiments. When in-depth analyses are focused on the mosquito-borne subgroup, the largest subgroup with the most diverse host range in the genus, similar correlations are again observed. Furthermore, in this subgroup, significant correlations are observed among branching order of the viral lineages characterized by unique arthropod and vertebrate hosts, gene length, and unique organization of the conserved sequences in the 3' noncoding region to each viral lineage. Collectively, multiple correlations among viral traits corroborate the validity of the phylogenetic tree based on the NS5 gene. Accordingly, our studies demonstrate the utility of a holistic approach to evaluate the soundness of phylogenetic tree proposed for flaviviruses and to better understand how two vector-borne subgroups with their host ranges in two phyla of animals evolved. Understanding this adaptive mechanism may provide insight into the molecular bases of the emergence of new zoonotic viral diseases of humans. Furthermore, the inconsistencies of the current taxonomy of flaviviruses revealed in this study should be seriously considred for taxonomic revision in the future. C1 [Kuno, Goro; Chang, Gwong-Jen J.] Ctr Dis Control & Prevent, Arboviral Dis Branch, Div Vector Borne Infect Dis, Ft Collins, CO USA. [Chien, Li-Jung] Ctr Dis Control, Taipei, Taiwan. RP Kuno, G (reprint author), Ctr Dis Control & Prevent, Arboviral Dis Branch, Div Vector Borne Infect Dis, Ft Collins, CO USA. EM gok1@cdc.gov NR 56 TC 3 Z9 3 U1 0 U2 1 PU NOVA SCIENCE PUBLISHERS, INC PI HAUPPAUGE PA 400 OSER AVE, STE 1600, HAUPPAUGE, NY 11788-3635 USA BN 978-1-60741-067-6 PY 2009 BP 1 EP 33 PG 33 WC Virology SC Virology GA BLV51 UT WOS:000271172700001 ER PT B AU Wu, XF Kuzmin, I Tang, K Rupprecht, CE AF Wu, Xianfu Kuzmin, Ivan Tang, Kelvin Rupprecht, Charles E. BE Feng, Z Long, M TI Lyssavirus Genome SO VIRAL GENOMES: DIVERSITY, PROPERTIES AND PARAMETERS LA English DT Article; Book Chapter DE Lyssavirus; Viral genome sequence; Genotyping; Phylogeny; Evolutionary driving force; Purifying selection; Point mutation; Recombination; Protein-protein interaction; Protein-RNA interaction; Trans- acting signal; Cis-acting signal ID VESICULAR STOMATITIS-VIRUS; AUSTRALIAN BAT LYSSAVIRUS; NUCLEOPROTEIN-RNA COMPLEX; FORMER SOVIET-UNION; RABIES-VIRUS; MATRIX PROTEIN; PHYLOGENETIC-RELATIONSHIPS; NUCLEOTIDE-SEQUENCE; PHOSPHOPROTEIN-P; LEADER RNA AB Despite obvious phylogenetic diversity within the Lyssavirus genus, generally, the viral genome has the same organization. Albeit 7 recognized and 4 putative genotypes have been proposed in lyssaviruses, more genotypes are seemingly being suggested. The Lagos bat virus (genotype 2) is being divided into novel or subgenotypes. Since viral full genome sequences provide rich information for various phylogenetic purposes, the partial single gene sequence once applied in phylogeny should be reevaluated. However, the available database for lyssavirus full genomes is very limited. After comparison of previous methodology in sequencing lyssavirus full genomes, a novel, simple and universal method was developed in our laboratory, which helped generate 4 full genome sequences for the putative lyssavirus genotypes: Aravan (ARAV), Khujand (KHUV), Irkut (IRV), and West Caucasian bat virus (WCBV). Lyssavirus is a single negative stranded RNA virus with a genome between 11 k and 12 k nucleotides (nts). Currently, the WCBV has the longest genome of 12278 nts in the genus. In gene organization, from the 3' to 5' extremity, the viral genome contains sequentially leader sequence, nucleoprotein (N), phosphoprotein (P), matrix (M), glycoprotein (G), RNA dependent RNA polymerase (L), psi (or G-L 3' non-translated region), and trailer region. The psi is between 400 and 700 nts long with no coding capacity or functionality. This redundancy is unique in the Lyssavirus genus. The relative conservativeness has revealed the gene order of N >L >M>G>P in the genome. No overall positive selection has been detected in lyssaviruses. The overwhelming evolutionary driving force is point mutation and purifying (deleterious) selection. Synonymous mutations are dominant while nonsynonymous sites are constrained. The few suggested recombinant events are probably due to subquality of the sequence database for the extrapolation. No solid biochemical model for explanation of recombination has been hypothesized in lyssaviruses. In contrast to the expanding diversity trend in genotypes, viral protein structures and functions are conserved in lyssaviruses. Extensive viral protein-protein, protein-RNA interactions have been investigated. Intensified co-variation sites have been detected within and among individual viral structural proteins. In addition, both trans- and cis- acting signals for viral transcription and replication are strictly conserved in lyssaviruses. C1 [Wu, Xianfu; Kuzmin, Ivan; Rupprecht, Charles E.] CDC, Ctr Dis Control & Prevent, Rabies Program, PRB,DVRD, Atlanta, GA 30333 USA. [Tang, Kelvin] Ctr Dis Control & Prevent, Biotechnol Core Facil Branch, Div Sci Resources, Atlanta, GA USA. RP Wu, XF (reprint author), CDC, Ctr Dis Control & Prevent, Rabies Program, PRB,DVRD, Bldg 17,Room 6045,MS-G33,1600 Clifton Rd, Atlanta, GA 30333 USA. EM XAW6@cdc.gov NR 150 TC 0 Z9 0 U1 0 U2 0 PU NOVA SCIENCE PUBLISHERS, INC PI HAUPPAUGE PA 400 OSER AVE, STE 1600, HAUPPAUGE, NY 11788-3635 USA BN 978-1-60741-067-6 PY 2009 BP 201 EP 248 PG 48 WC Virology SC Virology GA BLV51 UT WOS:000271172700010 ER PT J AU Charles, LE Loomis, D Demissie, Z AF Charles, Luenda E. Loomis, Dana Demissie, Zewditu TI Occupational hazards experienced by cleaning workers and janitors: A review of the epidemiologic literature SO WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION LA English DT Review DE Occupational exposures; cleaning; housekeeping; respiratory disease; low back pain ID HOTEL ROOM CLEANERS; FEMALE CLEANERS; RESPIRATORY SYMPTOMS; CHRONIC-BRONCHITIS; SKIN-DISEASE; BACK-PAIN; LAS-VEGAS; ASTHMA; RISK; WOMEN AB Building cleaners are an important group of workers who experience diverse occupational hazards resulting in health problems. A review of epidemiologic studies conducted between 1981 and 2005 was performed using PubMed and PsychLit, to identify health outcomes and the associated hazards in the work environment of cleaners. Among 35 studies, respiratory diseases (n = 17) and dermatologic diseases (n = 9) were the most common and were associated with exposure to cleaning agents, wet work, and rubber latex. The potential for infectious diseases (n = 3) was identified among cleaners in medical laboratories and was associated with exposure to broken glass and uncapped needles in the trash. Musculoskeletal disorders (n = 5) were associated with several physical stressors (e.g., awkward postures, prolonged standing) and psychosocial stressors (e.g., monotonous job, low potential for promotion). Mental disorders (n = 1) were also associated with psychosocial stressors and societal stigma. Future studies may be enhanced by better assessment of the specific job exposures of cleaners and implementation of a prospective design. C1 [Charles, Luenda E.] NIOSH, Hlth Effects Lab Div, Biostat & Epidemiol Branch, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. [Loomis, Dana] Univ Nevada, Sch Publ Hlth, Reno, NE USA. [Demissie, Zewditu] Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA. RP Charles, LE (reprint author), NIOSH, Hlth Effects Lab Div, Biostat & Epidemiol Branch, Ctr Dis Control & Prevent, 1095 Willowdale Rd,Mail Stop L-4050, Morgantown, WV 26505 USA. EM lcharles@cdc.gov RI Charles, Luenda/H-6008-2011 FU PHS HHS [T42/CCT422952] NR 59 TC 19 Z9 21 U1 1 U2 15 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1051-9815 J9 WORK JI Work PY 2009 VL 34 IS 1 BP 105 EP 116 DI 10.3233/WOR-2009-0907 PG 12 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 534AN UT WOS:000272868000012 PM 19923681 ER PT J AU Kirtland, KA Li, YF Geiss, LS Thompson, TJ AF Kirtland, K. A. Li, Y. F. Geiss, L. S. Thompson, T. J. TI State-Specific Incidence of Diabetes Among Adults Participating States, 1995-1997 and 2005-2007 (Reprinted from MMWR, vol 57, pg 1169-1173, 2008) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Kirtland, K. A.; Li, Y. F.; Geiss, L. S.; Thompson, T. J.] CDC, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. RP Kirtland, KA (reprint author), CDC, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. NR 1 TC 2 Z9 2 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 24 PY 2008 VL 300 IS 24 BP 2847 EP 2849 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 386ZG UT WOS:000261920900010 ER PT J AU Wattigney, WA Orr, MF Williamson, GD Jones, SE AF Wattigney, W. A. Orr, M. F. Williamson, G. D. Jones, S. Everett TI Hazardous Chemical Incidents in Schools-United States, 2002-2007 (Reprinted from MMWR, vol 57, pg 1197, 2008) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Wattigney, W. A.; Orr, M. F.; Williamson, G. D.] CDC, Div Hlth Studies, Agcy Tox Substances & Dis Registry, Atlanta, GA 30333 USA. [Jones, S. Everett] CDC, Div Adolescent & Sch Hlth, Atlanta, GA 30333 USA. RP Wattigney, WA (reprint author), CDC, Div Hlth Studies, Agcy Tox Substances & Dis Registry, Atlanta, GA 30333 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 24 PY 2008 VL 300 IS 24 BP 2849 EP 2850 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 386ZG UT WOS:000261920900011 ER PT J AU Artz, JD Dunford, JE Arrowood, MJ Dong, AP Chruszcz, M Kavanagh, KL Minor, W Russell, RGG Ebetino, FH Oppermann, U Hui, R AF Artz, Jennifer D. Dunford, James E. Arrowood, Michael J. Dong, Aiping Chruszcz, Maksymilian Kavanagh, Kathryn L. Minor, Wladek Russell, R. Graham G. Ebetino, F. Hal Oppermann, Udo Hui, Raymond TI Targeting a Uniquely Nonspecific Prenyl Synthase with Bisphosphonates to Combat Cryptosporidiosis SO CHEMISTRY & BIOLOGY LA English DT Article ID GERANYLGERANYL-DIPHOSPHATE SYNTHASE; NITROGEN-CONTAINING BISPHOSPHONATES; CHAIN-LENGTH DETERMINATION; OCTAPRENYL PYROPHOSPHATE SYNTHASE; IN-VITRO; CRYSTAL-STRUCTURE; ISOPENTENYL PYROPHOSPHATE; ISOPRENOID BIOSYNTHESIS; PLASMODIUM-FALCIPARUM; PRODUCT SPECIFICITY AB Cryptosporidiosis is a neglected disease without a wholly effective drug. We present a study demonstrating nitrogen-containing bisphosphonates (N-BPs) to be capable of inhibiting Cryptosporidium parvum at low micromolar concentrations in infected MDCK cells. Predictably, the mechanism of action is based on inhibition of biosynthesis of isoprenoids but the target enzyme is unexpectedly a distinctive C. parvum enzyme dubbed nonspecific polyprenyl pyrophosphate synthase (CpNPPPS). This enzyme produces various isoprenoid products larger than FPP and is inhibited by N-BPs at subnanomolar concentrations. It is part of an isoprenoid pathway in Cryptosporidium distinctly different from other organisms. The proposed mechanism of action is corroborated by crystal structures of the enzyme with risedronate and zoledronate bound showing how this enzyme's unique chain length determinant region enables it to accommodate larger substrates and products. These results, combined with existing data on their clinical use, demonstrate that N-BPs are very promising anticryptosporidial drug candidates. C1 [Artz, Jennifer D.; Dong, Aiping; Hui, Raymond] Univ Toronto, Struct Genom Consortium, Toronto, ON M5G 1L7, Canada. [Dunford, James E.; Kavanagh, Kathryn L.; Oppermann, Udo] Univ Oxford, Struct Genom Consortium, Oxford OX3 7DQ, England. [Dunford, James E.; Russell, R. Graham G.; Oppermann, Udo] Univ Oxford, Inst Musculoskeletal Sci, Nuffield Dept Orthopaed Surg, Botnar Res Ctr, Oxford OX3 7LD, England. [Arrowood, Michael J.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Chruszcz, Maksymilian; Minor, Wladek] Univ Virginia, Dept Mol Physiol & Biol Phys, Charlottesville, VA 22908 USA. [Ebetino, F. Hal] Procter & Gamble Pharmaceut Inc, Mason, OH 45040 USA. RP Hui, R (reprint author), Univ Toronto, Struct Genom Consortium, 101 Coll St, Toronto, ON M5G 1L7, Canada. EM Raymond.hui@utoronto.ca RI Chruszcz, Maksymilian/E-6407-2011; Minor, Wladek/F-3096-2014; OI Chruszcz, Maksymilian/0000-0001-7521-5485; Minor, Wladek/0000-0001-7075-7090; Artz, Jennifer/0000-0003-0500-6156 FU Canadian Institutes for Health Research; Canadian Foundation for Innovation; Genome Canada through the Ontario Genomics Institute, GIaxoSmithKline; Knut and Alice Wallenberg Foundation; Ontario Innovation Trust; Ontario Ministry for Research and Innovation; Merck Co. Inc.; Novartis Research Foundation; Petrus and Augusta Hedlund's Foundation; Swedish Agency for Innovation Systems; Swedish Foundation for Strategic Research; Wellcome Trust; McLaughlin Centre of Molecular Medicine; US NIH [GM074942] FX The authors would like to acknowledge the Structural Genomics Consortium (SGC), Jocelyne Lew for the cloning of CpNPPPS, Helen Ren for large scale expression, and Helping Zheng for correcting the Ramachandran outliers of CpNPPPS-ZOL. The BL21(DE3)R3-pRARE2 strain of Escherichia coli used came from Opher Gileadi of the SGC at the University of Oxford. The SGC is a registered charity (# 1097737) that receives funds from the Canadian Institutes for Health Research, the Canadian Foundation for Innovation, Genome Canada through the Ontario Genomics Institute, GIaxoSmithKline, the Knut and Alice Wallenberg Foundation, the Ontario Innovation Trust, the Ontario Ministry for Research and Innovation, Merck & Co. Inc., the Novartis Research Foundation, the Petrus and Augusta Hedlund's Foundation, the Swedish Agency for Innovation Systems, the Swedish Foundation for Strategic Research, and the Wellcome Trust. This research was also supported by funds from the McLaughlin Centre of Molecular Medicine. The methodological part of this work was also supported in part by US NIH grant GM074942. NR 55 TC 28 Z9 28 U1 0 U2 4 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1074-5521 J9 CHEM BIOL JI Chem. Biol. PD DEC 22 PY 2008 VL 15 IS 12 BP 1296 EP 1306 DI 10.1016/j.chembiol.2008.10.017 PG 11 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 389JV UT WOS:000262089600008 PM 19101474 ER PT J AU Biggerstaff, BJ Jackson, D AF Biggerstaff, Brad J. Jackson, Dan TI The exact distribution of Cochran's heterogeneity statistic in one-way random effects meta-analysis SO STATISTICS IN MEDICINE LA English DT Article DE normal quadratic form; DerSimonian-Laird estimator; saddlepoint approximation; homogeneity test ID TRIALS; POWER; VARIANCE; MODELS; TESTS AB The presence and impact of heterogeneity in the standard one-way random effects model in meta-analysis are often assessed using the Q statistic due to Cochran. We derive the exact distribution of this statistic under the assumptions of the random effects model, and also suggest two moment-based approximations and a saddlepoint approximation for Q. The exact and approximate distributions are then applied to obtain the corresponding distributions of the recently proposed heterogeneity Measures I(2) and H(M)(2), the power the standard test for the presence of heterogeneity and confidence intervals for the between-study variance parameter when the DerSimonian-Laird or the Hartung-Makambi estimator is used. The methodology is illustrated by revisiting a recent simulation study concerning the heterogeneity Measures and applying all the proposed methods to four published meta-analyses. Published in 2008 by John Wiley & Sons, Ltd. C1 [Biggerstaff, Brad J.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Ft Collins, CO 80521 USA. [Jackson, Dan] Inst Publ Hlth, MRC Biostat Unit, Cambridge CB2 0SR, England. RP Biggerstaff, BJ (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Ft Collins, CO 80521 USA. EM BBiggerstaff@cdc.gov FU Medical Research Council [MC_U105260558] NR 28 TC 42 Z9 43 U1 0 U2 7 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0277-6715 J9 STAT MED JI Stat. Med. PD DEC 20 PY 2008 VL 27 IS 29 BP 6093 EP 6110 DI 10.1002/sim.3428 PG 18 WC Mathematical & Computational Biology; Public, Environmental & Occupational Health; Medical Informatics; Medicine, Research & Experimental; Statistics & Probability SC Mathematical & Computational Biology; Public, Environmental & Occupational Health; Medical Informatics; Research & Experimental Medicine; Mathematics GA 383AS UT WOS:000261647100004 PM 18781561 ER PT J AU Blossom, DB Kallen, AJ Patel, PR Elward, A Robinson, L Gao, GP Langer, R Perkins, KM Jaeger, JL Kurkjian, KM Jones, M Schillie, SF Shehab, N Ketterer, D Venkataraman, G Kishimoto, TK Shriver, Z McMahon, AW Austen, KF Kozlowski, S Srinivasan, A Turabelidze, G Gould, CV Arduino, MJ Sasisekharan, R AF Blossom, David B. Kallen, Alexander J. Patel, Priti R. Elward, Alexis Robinson, Luke Gao, Ganpan Langer, Robert Perkins, Kiran M. Jaeger, Jennifer L. Kurkjian, Katie M. Jones, Marilyn Schillie, Sarah F. Shehab, Nadine Ketterer, Daniel Venkataraman, Ganesh Kishimoto, Takashi Kei Shriver, Zachary McMahon, Ann W. Austen, K. Frank Kozlowski, Steven Srinivasan, Arjun Turabelidze, George Gould, Carolyn V. Arduino, Matthew J. Sasisekharan, Ram TI Outbreak of Adverse Reactions Associated with Contaminated Heparin SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID ANAPHYLACTOID REACTIONS; CLINICAL EVENTS; HEMODIALYSIS AB Background: In January 2008, the Centers for Disease Control and Prevention began a nationwide investigation of severe adverse reactions that were first detected in a single hemodialysis facility. Preliminary findings suggested that heparin was a possible cause of the reactions. Methods: Information on clinical manifestations and on exposure was collected for patients who had signs and symptoms that were consistent with an allergic-type reaction after November 1, 2007. Twenty-one dialysis facilities that reported reactions and 23 facilities that reported no reactions were included in a case-control study to identify facility-level risk factors. Unopened heparin vials from facilities that reported reactions were tested for contaminants. Results: A total of 152 adverse reactions associated with heparin were identified in 113 patients from 13 states from November 19, 2007, through January 31, 2008. The use of heparin manufactured by Baxter Healthcare was the factor most strongly associated with reactions (present in 100.0% of case facilities vs. 4.3% of control facilities, P<0.001). Vials of heparin manufactured by Baxter from facilities that reported reactions contained a contaminant identified as oversulfated chondroitin sulfate (OSCS). Adverse reactions to the OSCS-contaminated heparin were often characterized by hypotension, nausea, and shortness of breath occurring within 30 minutes after administration. Of 130 reactions for which information on the heparin lot was available, 128 (98.5%) occurred in a facility that had OSCS-contaminated heparin on the premises. Of 54 reactions for which the lot number of administered heparin was known, 52 (96.3%) occurred after the administration of OSCS-contaminated heparin. Conclusions: Heparin contaminated with OSCS was epidemiologically linked to adverse reactions in this nationwide outbreak. The reported clinical features of many of the cases further support the conclusion that contamination of heparin with OSCS was the cause of the outbreak. C1 [Blossom, David B.; Kallen, Alexander J.; Patel, Priti R.; Schillie, Sarah F.; Shehab, Nadine; Srinivasan, Arjun; Gould, Carolyn V.; Arduino, Matthew J.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. [Blossom, David B.; Kallen, Alexander J.; Jaeger, Jennifer L.; Kurkjian, Katie M.; Schillie, Sarah F.] Ctr Dis Control & Prevent, Epidem Intelligence Serv Program, Atlanta, GA 30333 USA. [Blossom, David B.; Kallen, Alexander J.; Perkins, Kiran M.; Jaeger, Jennifer L.; Kurkjian, Katie M.; Schillie, Sarah F.; Ketterer, Daniel] Ctr Dis Control & Prevent, Off Workforce & Career Dev, Atlanta, GA 30333 USA. [Elward, Alexis] St Louis Childrens Hosp, St Louis, MO 63178 USA. [Jones, Marilyn] BJC Healthcare, St Louis, MO USA. [Turabelidze, George] Missouri Dept Hlth & Senior Serv, St Louis, MO USA. [Robinson, Luke; Gao, Ganpan; Langer, Robert; Sasisekharan, Ram] MIT, Dept Biol Engn, Cambridge, MA 02139 USA. [Langer, Robert] MIT, Dept Chem Engn, Cambridge, MA 02139 USA. [Langer, Robert; Sasisekharan, Ram] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA. [Robinson, Luke; Gao, Ganpan; Langer, Robert; Sasisekharan, Ram] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA. [Venkataraman, Ganesh; Kishimoto, Takashi Kei; Shriver, Zachary] Momenta Pharmaceut, Cambridge, MA USA. [McMahon, Ann W.; Kozlowski, Steven] US FDA, Ctr Drug Evaluat & Res, Silver Spring, MD USA. [Austen, K. Frank] Brigham & Womens Hosp, Boston, MA 02115 USA. [Austen, K. Frank] Harvard Univ, Sch Med, Boston, MA 02115 USA. RP Patel, PR (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, 1600 Clifton Rd,MS-A31, Atlanta, GA 30333 USA. EM ppatel@cdc.gov RI Arduino, Matthew/C-1461-2012 OI Arduino, Matthew/0000-0001-7072-538X FU National Institutes of Health [GM57073, HL080279]; Momenta Pharmaceuticals and Scientific Protein; Momenta Pharmaceuticals; SAGE Products; Pfizer; Lilly; Monsanto; Walgreens; General Electric; Abbott FX The CDC investigation had no external funding. The laboratory analysis was supported in part by grants from the National Institutes of Health (GM57073 and HL080279, to Dr. Sasisekharan).; Dr. Venkataraman reports being an employee of Momenta Pharmaceuticals and holding equity in the company, which performs the analysis and characterization of complex mixtures, including heparin, and being an inventor on patent applications for Momenta Pharmaceuticals; Dr. Kishimoto, being an employee of, holding equity in, and being an inventor on patent applications for Momenta Pharmaceuticals; Dr. Langer, receiving consulting fees from Momenta Pharmaceuticals and Scientific Protein, having equity in Momenta Pharmaceuticals, and serving on a paid board of Momenta Pharmaceuticals; Dr. Shriver, being an employee of Momenta Pharmaceuticals and holding equity in the company; Dr. Sasisekharan, holding equity in Momenta Pharmaceuticals and receiving consulting fees or serving on a paid board of Momenta Pharmaceuticals and Scientific Protein Labs; Dr. Austen, receiving consulting fees from Momenta Pharmaceuticals; Dr. Elward, receiving consulting fees or serving on a paid advisory board for Trinity and receiving grant support from SAGE Products; and Dr. Schillie, holding equity in Pfizer, Lilly, Monsanto, Walgreens, General Electric, and Abbott. No other potential conflict of interest relevant to this article was reported.; The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. Use of trade names and commercial sources is for identification only and does not imply endorsement by the U. S. Department of Health and Human Services.; We thank the many health care professionals at facilities at which adverse events occurred for reporting to public health authorities and for sending heparin vials for laboratory testing; the state epidemiologists and representatives of the End Stage Renal Disease Network for their assistance in facilitating contact between facilities with adverse events and the CDC; Laura Governale ( IMS Health), Gary Warns ( Gambro), and Bill Singley ( Minntech) for the timely information they provided; and representatives of the FDA for their close collaboration, especially in the early stages of this outbreak investigation, in particular, Karen Deasy and Tarun Mallick, who served as important links between the FDA and the CDC and furthered our collective efforts. NR 22 TC 134 Z9 138 U1 3 U2 7 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD DEC 18 PY 2008 VL 359 IS 25 BP 2674 EP 2684 DI 10.1056/NEJMoa0806450 PG 11 WC Medicine, General & Internal SC General & Internal Medicine GA 384PS UT WOS:000261757300007 PM 19052120 ER PT J AU Kemperman, M Neitzel, D Jensen, K Gorlin, J Perry, E Myers, T Miley, T McQuiston, J Eremeeva, ME Nicholson, W Singleton, J Adjemian, J AF Kemperman, M. Neitzel, D. Jensen, K. Gorlin, J. Perry, E. Myers, T. Miley, T. McQuiston, J. Eremeeva, M. E. Nicholson, W. Singleton, J. Adjemian, J. TI Anaplasma phagocytophilum Transmitted Through Blood Transfusion-Minnesota, 2007 (Reprinted from MMWR, vol 57, pg 1145-1148, 2008) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint ID HUMAN GRANULOCYTIC EHRLICHIOSIS; TRANSMISSION; SURVIVAL; DISEASE C1 [Kemperman, M.; Neitzel, D.] Minnesota Dept Hlth, St Paul, MN 55164 USA. [Jensen, K.; Gorlin, J.; Perry, E.] Mem Blood Ctr, St Paul, MN USA. [Myers, T.; Miley, T.] Park Nicollet Methodist Hosp, St Louis, MO USA. [McQuiston, J.; Eremeeva, M. E.; Nicholson, W.; Singleton, J.] Natl Ctr Zoonot Vectorborne & Enter Dis, Atlanta, GA USA. [Adjemian, J.] CDC, Atlanta, GA 30333 USA. RP Kemperman, M (reprint author), Minnesota Dept Hlth, St Paul, MN 55164 USA. NR 11 TC 0 Z9 0 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 17 PY 2008 VL 300 IS 23 BP 2718 EP 2720 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 384FJ UT WOS:000261730400006 ER PT J AU Penfield, S Flood, J Lang, W Zanker, M Haddad, MB Alvarado-Ramy, F Leidel, L Fowler, G Modi, S Brown, C Averhoff, F Cetron, MS AF Penfield, S. Flood, J. Lang, W. Zanker, M. Haddad, M. B. Alvarado-Ramy, F. Leidel, L. Fowler, G. Modi, S. Brown, C. Averhoff, F. Cetron, M. S. TI Federal Air Travel Restrictions for Public Health Purposes United States, June 2007-May 2008 (Reprinted from MMWR, vol 57, pg 1009-1012, 2008) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint ID MYCOBACTERIUM-TUBERCULOSIS; TRANSMISSION C1 [Penfield, S.] Texas Dept State Hlth Svcs, Austin, TX 78756 USA. [Flood, J.] Calif Dept Publ Hlth, Ctr Infect Dis, Berkeley, CA USA. [Lang, W.; Zanker, M.] US Dept Homeland Secur, Off Hlth Affairs, New York, NY USA. [Haddad, M. B.] Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div TB Eliminat, Atlanta, GA USA. [Alvarado-Ramy, F.; Leidel, L.; Fowler, G.; Modi, S.; Brown, C.; Averhoff, F.; Cetron, M. S.] CDC, Div Global Migrat & Quarantine, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA 30333 USA. RP Penfield, S (reprint author), Texas Dept State Hlth Svcs, Austin, TX 78756 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 17 PY 2008 VL 300 IS 23 BP 2720 EP 2722 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 384FJ UT WOS:000261730400007 ER PT J AU Lopez, A Caceres, VM AF Lopez, Augusto Caceres, Victor M. TI Central America Field Epidemiology Training Program (CA FETP): a pathway to sustainable public health capacity development SO HUMAN RESOURCES FOR HEALTH LA English DT Review ID SERVICE AB The Central America Field Epidemiology Training Program (CA FETP) is a public health capacity-building training programme aimed at developing high-caliber field epidemiologists at various levels of the public health system. It began in 2000 as part of the effort to rebuild public health infrastructure in six Central American and Caribbean countries following the devastation of Hurricanes Mitch and Georges in late 1998. Since then, the CA FETP has evolved from one regional training programme managed by CDC to several national FETPs with each country assuming ownership of its domestic programme. The curriculum is competency-based, and is divided into a three-tiered training pyramid that corresponds to the needs at the local, district and central levels of the health system. Trainees at each tier spend about 20% of their time in the classroom and 80% in the field implementing what they have learned while being mentored by graduates of the programme. FETP trainees have responded to multiple natural disasters and conducted hundreds of investigations including surveillance evaluations, outbreak responses and planned studies. Also graduates of the CA FETP are assuming influential positions in their respective ministries. As countries meet the challenge of institutionalizing their programmes, the CA FETP concept will increasingly be recognized as a model for sustainable public health capacity development. C1 [Lopez, Augusto; Caceres, Victor M.] Ctr Dis Control & Prevent, Coordinating Off Global Hlth, Div Global Publ Hlth Capac Dev, Atlanta, GA 30333 USA. RP Caceres, VM (reprint author), Ctr Dis Control & Prevent, Coordinating Off Global Hlth, Div Global Publ Hlth Capac Dev, 1600 Clifton Rd MS E-93, Atlanta, GA 30333 USA. EM alopez@gt.cdc.gov; vac5@cdc.gov NR 3 TC 14 Z9 14 U1 1 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA CURRENT SCIENCE GROUP, MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1478-4491 J9 HUM RESOUR HEALTH JI Hum. Resour. Health PD DEC 16 PY 2008 VL 6 AR 27 DI 10.1186/1478-4491-6-27 PG 6 WC Health Policy & Services; Industrial Relations & Labor SC Health Care Sciences & Services; Business & Economics GA 432GH UT WOS:000265121000001 PM 19087253 ER PT J AU Omer, SB Enger, KS Moulton, LH Halsey, NA Stokley, S Salmon, DA AF Omer, Saad B. Enger, Kyle S. Moulton, Lawrence H. Halsey, Neal A. Stokley, Shannon Salmon, Daniel A. TI Geographic Clustering of Nonmedical Exemptions to School Immunization Requirements and Associations With Geographic Clustering of Pertussis SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article DE cluster analysis; geographic information systems; immunization; space-time clustering; vaccines; whooping cough ID VACCINE SAFETY; UNITED-STATES; MEASLES; POLICIES; LAWS AB School immunization requirements are important in controlling vaccine-preventable diseases in the United States. Forty-eight states offer nonmedical exemptions to school immunization requirements. Children with exemptions are at increased risk of contracting and transmitting vaccine-preventable diseases. The clustering of nonmedical exemptions can affect community risk of vaccine-preventable diseases. The authors evaluated spatial clustering of nonmedical exemptions in Michigan and geographic overlap between exemptions clusters and clusters of reported pertussis cases. Kulldorf's scan statistic identified 23 statistically significant census tract clusters for exemption rates and 6 significant census tract clusters for reported pertussis cases between 1993 and 2004. The time frames for significant space-time pertussis clusters were August 1993-September 1993, August 1994-February 1995, May 1998-June 1998, April 2002, May 2003-July 2003, and June 2004-November 2004. Census tracts in exemptions clusters were more likely to be in pertussis clusters (odds ratio = 3.0, 95% confidence interval: 2.5, 3.6). The overlap of exemptions clusters and pertussis clusters remained significant after adjustment for population density, proportion of racial/ethnic minorities, proportion of children aged 5 years or younger, percentage of persons below the poverty level, and average family size (odds ratio = 2.7, 95% confidence interval: 2.2, 3.3). Geographic pockets of vaccine exemptors pose a risk to the whole community. In addition to monitoring state-level exemption rates, health authorities should be mindful of within-state heterogeneity. C1 [Omer, Saad B.; Moulton, Lawrence H.; Halsey, Neal A.; Salmon, Daniel A.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA. [Omer, Saad B.; Moulton, Lawrence H.; Halsey, Neal A.; Salmon, Daniel A.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Inst Vaccine Safety, Baltimore, MD USA. [Enger, Kyle S.] Michigan Dept Community Hlth, Div Immunizat, Lansing, MI USA. [Stokley, Shannon] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Omer, SB (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, 615 N Wolfe St,Room E5537, Baltimore, MD 21205 USA. EM somer@jhsph.edu RI Omer, Saad/K-1182-2012; OI Omer, Saad/0000-0002-5383-3474; Moulton, Lawrence/0000-0001-7041-7387 FU Centers for Disease Control and Prevention (CDC) [UlPOO0032A]; CDC's IIS [Immunization Information Systems] [522556] FX This research was funded by grant UlPOO0032A from the Centers for Disease Control and Prevention (CDC). Kyle S. Enger's salary is funded by the CDC's IIS [Immunization Information Systems] Sentinel Site Project (grant 522556). NR 29 TC 115 Z9 118 U1 3 U2 17 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD DEC 15 PY 2008 VL 168 IS 12 BP 1389 EP 1396 DI 10.1093/aje/kwn263 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 383OO UT WOS:000261683100007 PM 18922998 ER PT J AU Erguder, T Cakir, B Aslan, D Warren, CW Jones, NR Asma, S AF Erguder, Toker Cakir, Banu Aslan, Dilek Warren, Charles W. Jones, Nathan R. Asma, Samira TI Evaluation of the use of Global Youth Tobacco Survey (GYTS) data for developing evidence-based tobacco control policies in Turkey SO BMC PUBLIC HEALTH LA English DT Article ID ADOLESCENTS; SMOKING AB Introduction: The tobacco control effort in Turkey has made significant progress in recent years. Turkey initiated its tobacco control effort with the passing of Law 4207 (The Prevention of Harmful Effects of Tobacco Products) in 1996 and ratified the World Health Organization (WHO) Framework Convention on Tobacco Control (FCTC) in 2004. It is important to base policy decisions on valid and reliable evidence from population-based, representative studies that are periodically repeated to enable policy makers to monitor the results of their interventions and to appropriately tailor anti-tobacco activities towards future needs. Methods: The Global Youth Tobacco Survey (GYTS) was developed to track tobacco use among young people and enhance the capacity of countries to design, implement, and evaluate tobacco control and prevention programs. Turkey conducted the GYTS in 2003 and data from this survey can be used as baseline measures for evaluation of the tobacco control programs implemented by the Ministry of Health (MOH) of the Turkish government. Results: The GYTS was conducted in 2003 on a representative sample of students aged 13 to 15 years. It indicated that almost 3 in 10 students in Turkey had ever smoked cigarettes, with significantly higher rates among boys. Current cigarette smoking rates were lower, at 9% for boys and 4% for girls. The prevalence of current use of other tobacco products was about half these figures for each gender. About 80% were exposed to secondhand smoke. Exposure to pro-smoking media messages was not rare. Almost half of the smokers 'usually' bought their tobacco from a store, despite the law prohibiting this. Exposure to teaching against smoking in schools was not universal. Conclusion: Findings from the GYTS, with periodic repeats of the survey, can be used to monitor the impact of enforcing various provisions of the present law (No: 4207), the progress made in achieving the goals of the WHO FCTC, and the effectiveness of various preventive interventions against smoking. Such data would inform and help in the development of public health strategy. C1 [Erguder, Toker] World Hlth Org Country Off, TR-06610 Ankara, Turkey. [Cakir, Banu; Aslan, Dilek] Hacettepe Univ, Fac Med, Dept Publ Hlth, TR-06100 Ankara, Turkey. [Warren, Charles W.; Jones, Nathan R.; Asma, Samira] Ctr Dis Control & Prevent, Off Smoking & Hlth, Atlanta, GA 30341 USA. RP Erguder, T (reprint author), World Hlth Org Country Off, Birlik Mahallesi 2,Cadde 11, TR-06610 Ankara, Turkey. EM ergudert@euro.who.int; cakir@tr.net; daslan@hacettepe.edu.tr; wcw1@cdc.gov; njones@uwccc.wisc.edu; sea5@cdc.gov FU World Health Organization-Tobacco Free Initiative; US Centers for Disease Control and Prevention; Turkish Ministry of Health, Primary Health Care General Directorate, Mental Health Department of Primary Health General Directorate, Substance Dependence Section of Mental Health Department; Ministry of Education, Turkey FX This survey was supported financially and technically by the World Health Organization-Tobacco Free Initiative and the US Centers for Disease Control and Prevention; the Turkish Ministry of Health, Primary Health Care General Directorate, Mental Health Department of Primary Health General Directorate, Substance Dependence Section of Mental Health Department; and the Ministry of Education, Turkey. The authors would like to acknowledge the directors, school personnel and students of schools that participated in the study; the Ministry of Education for giving permission for this survey; Ms Ionela Petrea (Technical Officer, Tobacco Free Initiative-WHO Regional Office for Europe), Dr Mark Tabladillo, Ms Juliette Lee and Ms Veronica Lea (Epidemiologists, CDC-office on Smoking and Health) for their help in the organization and implementation of this survey and the completion of this report; and Turkish colleagues at Provincial Mental Health Departments who contributed to the successful implementation and field work of this study. NR 17 TC 13 Z9 13 U1 1 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD DEC 15 PY 2008 VL 8 SU 1 AR S4 DI 10.1186/1471-2458-8-S1-S4 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 604BA UT WOS:000278251100004 PM 19091047 ER PT J AU Sirichotiratana, N Techatraisakdi, C Rahman, K Warren, CW Jones, NR Asma, S Lee, J AF Sirichotiratana, Nithat Techatraisakdi, Chairat Rahman, Khalillur Warren, Charles W. Jones, Nathan R. Asma, Samira Lee, Juliette TI Prevalence of smoking and other smoking-related behaviors reported by the Global Youth Tobacco Survey (GYTS) in Thailand SO BMC PUBLIC HEALTH LA English DT Article AB Introduction: Thailand ratified the World Health Organization (WHO) Framework Convention on Tobacco Control (FCTC) on November 8, 2004. The WHO FCTC requires all parties to inform all persons of the health consequences of tobacco consumption and exposure to tobacco smoke. Each party has agreed to develop, implement and evaluate effective tobacco control programs to measure progress in reaching the goals of the WHO FCTC. Methods: The Global Youth Tobacco Survey (GYTS) was developed to provide data on youth tobacco use to countries for their development of youth-based tobacco control programs. Data in this report can be used as baseline measures for future evaluation of the tobacco control programs implemented by the Ministry of Public Health. Results: Overall, about 1 in 10 Thai students are current smokers, this number including 4 times more boys than girls (17% versus 3.9%). Almost 2 in 10 Thai students start smoking before the age of 10, and almost 7 in 10 students are reported to have been exposed to smoke from others in public places. About 4 in 10 students are reported to have an object with a cigarette brand logo on it. Conclusion: The key for Thailand is to implement and enforce the provisions on indirect tobacco advertising, smoking in public places, selling tobacco to youths under 18 years of age, and to use the data from the GYTS to monitor progress toward achieving the goals of the WHO FCTC. When these goals are met, tobacco consumption and exposure in Thailand will have declined substantially. C1 [Sirichotiratana, Nithat] Mahidol Univ, Fac Publ Hlth, Dept Hlth Adm, Bangkok 10400, Thailand. [Techatraisakdi, Chairat] Minist Publ Hlth, Dis Control Dept, Nonthaburi 11000, Thailand. [Rahman, Khalillur] WHO SE Asia Reg Off, Tobacco Free Initiat, New Delhi 110002, India. [Warren, Charles W.; Jones, Nathan R.; Asma, Samira; Lee, Juliette] Ctr Dis Control & Prevent, Off Smoking & Hlth, Atlanta, GA 30341 USA. RP Sirichotiratana, N (reprint author), Mahidol Univ, Fac Publ Hlth, Dept Hlth Adm, 420-1 Rajvithi Rd, Bangkok 10400, Thailand. EM nithats@hotmail.com; chairat_sk@yahoo.com; rahmank@searo.who.int; wcw1@cdc.gov; njones@uwccc.wisc.edu; sea5@cdc.gov; jpa7@cdc.gov FU Office on Smoking and Health of the US Centers for Disease Control and Prevention; WHO-SEARO; Ministry of Education; Thailand Health Promotion Institute FX We sincerely thank the Office on Smoking and Health of the US Centers for Disease Control and Prevention for providing technical assistance and support throughout the project. We gratefully acknowledge the help in coordinating this study, and the cooperation and funding support from WHO-SEARO for the project. We are thankful to the staff of Tobacco Free Initiative, WHO SEARO for their energy, encouragement, and expert advice. This project would not be successful without the cooperation, coordination and assistance in data collection received from Dr Chairat Techatraisakdi and his staff at Tobacco Control Section, Diseases Control Department, Thai Ministry of Public Health, and various other personnel at the Regional Diseases Control Centers around the country. We also gratefully acknowledge the help and assistance from the Ministry of Education, various school principals, personnel, staff and students around the country who participated in this project. Without their full support, we could not have accomplished what we have. Special thanks to Dr Hatai Chitanondh, President of Thailand Health Promotion Institute, for his vision, encouragement, advice, recommendations and support for the project. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 16 TC 6 Z9 7 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD DEC 15 PY 2008 VL 8 SU 1 AR S3 DI 10.1186/1471-2458-8-S1-S3 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 604BA UT WOS:000278251100003 PM 19091046 ER PT J AU Warren, CW AF Warren, Charles W. TI The Global Youth Tobacco Survey (GYTS): linking data to the implementation of the WHO Framework Convention on Tobacco Control Introduction SO BMC PUBLIC HEALTH LA English DT Editorial Material C1 Ctr Dis Control & Prevent, Off Smoking & Hlth, Global Tobacco Control Program, Atlanta, GA 30341 USA. RP Warren, CW (reprint author), Ctr Dis Control & Prevent, Off Smoking & Hlth, Global Tobacco Control Program, 3005 Chamblee Tucker Rd, Atlanta, GA 30341 USA. EM wcw1@cdc.gov NR 0 TC 3 Z9 3 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD DEC 15 PY 2008 VL 8 SU 1 AR S1 DI 10.1186/1471-2458-8-S1-S1 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 604BA UT WOS:000278251100001 PM 19091044 ER PT J AU Zavaleta, A Salas, M Peruga, A Hallal, ALC Warren, CW Jones, NR Asma, S AF Zavaleta, Alfonso Salas, Maria Peruga, Armando Hallal, Ana Luiza Curi Warren, Charles W. Jones, Nathan R. Asma, Samira TI Prevalence of smoking and other smoking related behaviors reported by the Global Youth Tobacco Survey (GYTS) in four Peruvian cities SO BMC PUBLIC HEALTH LA English DT Article AB Introduction: In 2004, Peru ratified the Health Organization (WHO) Framework Convention on Tobacco Control (FCTC) and in 2006 passed Law 28705 for tobacco consumption and exposure reduction. The Global Youth Tobacco Survey (GYTS) provides data on youth tobacco use for development of tobacco control programs. Findings from the GYTS conducted in four main cities in Peru in 2000 and 2003 are reported in this paper and can be used to monitor provisions of the WHO FCTC. Methods: The GYTS is a school-based survey that uses a standardized methodology for sampling, questionnaire construction, field procedures, and data management. In total, 5,332 and 7,824 students aged 13 to 15 years participated in the 2000 and 2003 surveys conducted in Huancayo, Lima, Tarapoto and Trujillo. Results: In both years, Lima had the highest lifetime (54.6% and 59.6%) and current use of tobacco (18.6% and 19.2%) of the four cities. According to gender, boys smoked more than girls and less than 20% of students initiated smoking before the age of 10. Among smokers, more than 60% bought their cigarettes in a store with no restriction for their age, and approximately 12% had ever been offered "free cigarettes". Around 90% of students were in favor of banning smoking in public places. Changes between 2000 and 2003 included an increase in the percentage of smokers who wanted to have a cigarette first thing in the morning in Tarapoto (from 0% to 1.2%) and a decrease in exposure to tobacco at home in Huancayo (from 23.7% to 17.8%) and Trujillo (from 27.8% to 19.8%) Conclusion: While few changes in tobacco use among youth have been observed in the GYTS in Peru, the data in this report can be used as baseline measures for future evaluation efforts. At this time, tobacco control efforts in Peru need to focus on enhancing Law 28705 to include enforcement of existing provisions and inclusion of new laws and regulations. Most of these provisions are required of all countries, such as Peru, that have ratified the WHO FCTC. C1 [Zavaleta, Alfonso] Ctr Informac & Educ Prevenc Abuso Drogas Cedro, Lima 18, Peru. [Zavaleta, Alfonso; Salas, Maria] Peruvian Univ Cayetano Heredia, Fac Sci & Philosophy, Dept Biochem Mol Biol & Pharmacol, Lima 30, Peru. [Peruga, Armando] WHO, Tobacco Free Initiat, CH-1211 Geneva, Switzerland. [Hallal, Ana Luiza Curi] Pan Amer Hlth Org, Tobacco Control & Consumers Hlth Team, Washington, DC 20037 USA. [Warren, Charles W.; Jones, Nathan R.; Asma, Samira] Ctr Dis Control & Prevent, Off Smoking & Hlth, Atlanta, GA 30341 USA. RP Zavaleta, A (reprint author), Ctr Informac & Educ Prevenc Abuso Drogas Cedro, Av Roca & Bolona 271, Lima 18, Peru. EM azavale@terra.com.pe; cleofe@viabcp.com; PerugaA@who.int; curihala@gmail.com; wcw1@cdc.gov; njones@uwccc.wisc.edu; sea5@cdc.gov FU PAHO FX We sincerely thank Eduardo Romero and Viviana Maldonado from Cedro Research Area and Eva Chaname from Nursing Faculty of Cayetano Heredia Peruvian University for their collaboration in the survey. We wish to thank PAHO for their financial support. NR 26 TC 2 Z9 2 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD DEC 15 PY 2008 VL 8 SU 1 AR S2 DI 10.1186/1471-2458-8-S1-S2 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 604BA UT WOS:000278251100002 PM 19091045 ER PT J AU Hlavsa, MC Kammerer, JS Moonan, PK AF Hlavsa, Michele C. Kammerer, J. Steve Moonan, Patrick K. TI Reply to Lin SO CLINICAL INFECTIOUS DISEASES LA English DT Letter C1 [Hlavsa, Michele C.] Ctr Dis Control & Prevent, Div Parasit Dis, Off Workforce & Career Dev, Epidem Intelligence Serv, Atlanta, GA 30341 USA. [Hlavsa, Michele C.; Kammerer, J. Steve; Moonan, Patrick K.] CDC, Natl Ctr HIV AIDS Viral Hepatitis Sexually Transm, Div Tuberculosis, Atlanta, GA 30333 USA. [Kammerer, J. Steve] Northup Grumman, Atlanta, GA USA. RP Hlavsa, MC (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis, Off Workforce & Career Dev, Epidem Intelligence Serv, 4770 Buford Hwy,MS F-22, Atlanta, GA 30341 USA. EM acz3@cdc.gov RI Moonan, Patrick/F-4307-2014; OI Moonan, Patrick/0000-0002-3550-2065 NR 2 TC 0 Z9 0 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD DEC 15 PY 2008 VL 47 IS 12 BP 1609 EP 1609 DI 10.1086/593364 PG 1 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 376DO UT WOS:000261163600029 ER PT J AU Moore, DM Awor, A Downing, R Kaplan, J Montaner, JSG Hancock, J Were, W Mermin, J AF Moore, David M. Awor, Anna Downing, Robert Kaplan, Jonathan Montaner, Julio S. G. Hancock, John Were, Willy Mermin, Jonathan TI CD4(+) T-Cell Count Monitoring Does Not Accurately Identify HIV-Infected Adults With Virologic Failure Receiving Antiretroviral Therapy SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE Africa; antiretroviral therapy; CD4 cell count; virologic suppression ID RESOURCE-LIMITED SETTINGS; RESPONSES; UGANDA; ADHERENCE; PROGRAM AB Background: CD4(+) T-lymphocyte (CD4) counts are widely used to monitor response to antiretroviral therapy (ART) in resource-limited settings. However, the utility of such monitoring in terms of predicting virologic response to therapy has been little studied. Methods: We studied participants aged 18 years and older who initiated ART in Tororo, Uganda. CD4 counts, CD4 percentages, and viral load (VL) were examined at 6-monthly intervals. Various definitions of immunologic failure were examined to identify individuals with VLs >= 50, >= 500, >= 1000, or >= 5000 copies per milliliter at 6, 12, and 18 months after treatment initiation. Results: One thousand sixty-three ART-naive persons initiated ART. The proportion of individuals with virologic failure ranged between 1.5% and 16.4% for each time point. The proportion with no increase in CD4 Count front baseline did not differ between those with Suppressed or unsuppressed VLs at 6, 18, and 24 months after ART initiation. No increase in CD4 Cell Counts at 6 months had a sensitivity of 0.04 [95% confidence interval (CI) 0.00 to 0.10] and a positive predictive value of 0.03 (95% CI 0.00 to 0.09) for identifying individuals with VL >= 500 copies per milliliter at 6 months. The best measure identified was an absolute CD4 cell count <125 cells per microliter at 21 months for predicting VL >= 500 copies per milliliter at 18 months which had a sensitivity of 0.13 (95% CI 0.01 to 0.21) and a positive predictive value of 0.29 (95% CI 0.10 to 0.44). Conclusions: CD4 cell count monitoring does not accurately identify individuals with virologic failure among patients taking ART. C1 [Moore, David M.; Montaner, Julio S. G.] British Columbia Ctr Excellence HIV AIDS, Vancouver, BC V6T 1Y6, Canada. [Moore, David M.; Awor, Anna; Downing, Robert; Hancock, John; Were, Willy; Mermin, Jonathan] US Ctr Dis Control & Prevent, Global AIDS Program, Entebbe, Uganda. [Moore, David M.; Montaner, Julio S. G.] Univ British Columbia, Fac Med, Dept Med, Vancouver, BC, Canada. [Kaplan, Jonathan] US Ctr Dis Control & Prevent, Global AIDS Program, Atlanta, GA USA. RP Moore, DM (reprint author), British Columbia Ctr Excellence HIV AIDS, 608-1081 Burrard St, Vancouver, BC V6T 1Y6, Canada. EM dmoore@cfenet.ubc.ca RI Mermin, Jonathan/J-9847-2012 NR 18 TC 72 Z9 74 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD DEC 15 PY 2008 VL 49 IS 5 BP 477 EP 484 DI 10.1097/QAI.0b013e318186eb18 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 376YN UT WOS:000261219000003 PM 18989232 ER PT J AU Park, IH Moore, MR Treanor, JJ Pelton, SI Pilishvili, T Beall, B Shelly, MA Mahon, BE Nahm, MH AF Park, In H. Moore, Matthew R. Treanor, John J. Pelton, Stephen I. Pilishvili, Tamara Beall, Bernard Shelly, Mark A. Mahon, Barbara E. Nahm, Moon H. CA Active Bacterial Core Surveillance TI Differential Effects of Pneumococcal Vaccines against Serotypes 6A and 6C SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID CONJUGATE VACCINE; STREPTOCOCCUS-PNEUMONIAE; UNITED-STATES; NASOPHARYNGEAL CARRIAGE; 7-VALENT CONJUGATE; DISEASE; CHILDREN; 19A; VALIDATION; REDUCTION AB Background. Because classic pneumococcal serotyping methods cannot distinguish between serotypes 6A and 6C, the effects of pneumococcal vaccines against serotype 6C are unknown. Pneumococcal vaccines contain serotype 6B but not serotypes 6A and 6C. Methods. We used a phagocytic killing assay to estimate the immunogenicity of the 7-valent conjugate vaccine (PCV7) in children and the 23-valent polysaccharide vaccine (PPV23) in adults against serotypes 6A and 6C. We evaluated trends in invasive pneumococcal disease (IPD) caused by serotypes 6A and 6C in the United States, using active surveillance. Results. Serum specimens from PCV7-immunized children had median opsonization indices of 150 and < 20 for serotypes 6A and 6C, respectively. Similarly, only 52% of adults (25 of 48) vaccinated with PPV23 showed opsonic indices of > 20 against serotype 6C. During 1999-2006, the incidence of serotype 6A IPD decreased by 91% (from 4.9 to 0.46 cases per 100,000 persons; P < .05) among individuals aged < 5 years and by 58% (from 0.86 to 0.36 cases per 100,000 persons; P < .05) among those aged >= 5 years. Although the incidence of 6C IPD showed no consistent trend (range, 0-0.6 cases per 100,000 persons) among individuals aged < 5 years, it increased from 0.25 to 0.62 cases per 100,000 persons (P < .05) among those aged >= 5 years. Conclusions. PCV7 introduction has led to reductions in serotype 6A IPD but not serotype 6C IPD in the United States. C1 [Park, In H.; Nahm, Moon H.] Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA. [Nahm, Moon H.] Univ Alabama, Dept Microbiol, Birmingham, AL 35294 USA. [Moore, Matthew R.; Pilishvili, Tamara; Beall, Bernard] Ctr Dis Control & Prevent, Resp Dis Branch, Atlanta, GA USA. [Treanor, John J.; Shelly, Mark A.] Univ Rochester, Dept Med, Rochester, NY USA. [Pelton, Stephen I.; Mahon, Barbara E.] Boston Univ, Dept Pediat, Boston, MA 02215 USA. [Mahon, Barbara E.] Novartis Vaccines & Diagnost, Cambridge, MA USA. RP Nahm, MH (reprint author), Univ Alabama, Dept Pathol, Bevill Biomed Res Bldg,Rm 614,845 19th St S, Birmingham, AL 35294 USA. EM nahm@UAB.edu OI Nahm, Moon/0000-0002-6922-1042; Pelton, Stephen/0000-0003-4862-5344 FU National Institutes of Health [AI-30021, N01-AI-45248, AI-31473]; Emerging Infections Program and Antimicrobial Resistance Working Group; Centers for Disease Control and Prevention [K01 CI000301-01] FX Financial support: National Institutes of Health (grants AI-30021 to M.H.N., N01-AI-45248 to J.J.T., and AI-31473 to M.H.N.); Emerging Infections Program and Antimicrobial Resistance Working Group, Centers for Disease Control and Prevention (grant K01 CI000301-01 to B.E.M.). NR 30 TC 99 Z9 101 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 15 PY 2008 VL 198 IS 12 BP 1818 EP 1822 DI 10.1086/593339 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 376QB UT WOS:000261197000009 PM 18983249 ER PT J AU Panuwet, P Prapamontol, T Chantara, S Thavornyuthikarn, P Montesano, MA Whitehead, RD Barr, DB AF Panuwet, Parinya Prapamontol, Tippawan Chantara, Somporn Thavornyuthikarn, Prasak Montesano, M. Angela Whitehead, Ralph D., Jr. Barr, Dana B. TI Concentrations of urinary pesticide metabolites in small-scale farmers in Chiang Mai Province, Thailand SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Pesticides; Biomonitoring; Farmers; Exposure assessment; Urinary metabolites ID TANDEM MASS-SPECTROMETRY; ORGANOPHOSPHORUS PESTICIDES; EXPOSURE; ETHYLENETHIOUREA; QUANTIFICATION; FARMWORKER; DIMETHOATE AB Our research goal was to assess exposure to currently used pesticides among small-scale male farmers residing in two topographically different areas in Chiang Mai Province, Thailand. Farmers (N=136) were recruited from Pong Yaeng subdistrict (N=67) and Inthakhin subdistrict (N=69). Each fanner provided a morning urine void for the analysis of 30 urinary metabolites of insecticides, herbicides, and fungicides. Fanners in Pong Yaeng had significantly higher urinary concentrations of metabolites of organophosphorus insecticides and ethylene bisdithiocarbamates, while farmers from Inthakhin had significantly higher concentrations of malathion, 2,4-D, alachlor, and parathion or EPN metabolites. Based upon the metabolites measured in the urine of the farmers, chlorpyrifos and pyrethroid insecticides seemed to be commonly used across both communities; no significant differences in metabolite concentrations of these insecticides were observed between the two farmer groups. The presence of methamidaphos in the urine of farmers suggests that, despite a ban on its use, methamidaphos continues to be used in the communities. A similar finding with metabolites of methyl parathion must be further investigated. Overall, our results suggest that while each community may use different pesticides, Thai farmers are exposed to a wide variety of pesticides with a broad range in exposure magnitude. Furthermore, age, field size, crop production type, and the use of protective equipment were found to be potential factors influencing the degree of exposure. (C) 2008 Elsevier B.V. All rights reserved. C1 [Prapamontol, Tippawan] Chiang Mai Univ, Res Inst Hlth Sci RIHES, Pollut & Environm Hlth Res Program, Chiang Mai 50200, Thailand. [Panuwet, Parinya] Chiang Mai Univ, Fac Sci, Environm Sci PhD Program, Chiang Mai 50200, Thailand. [Panuwet, Parinya; Montesano, M. Angela; Whitehead, Ralph D., Jr.; Barr, Dana B.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Chantara, Somporn; Thavornyuthikarn, Prasak] Chiang Mai Univ, Fac Sci, Dept Chem, Chiang Mai 50200, Thailand. RP Prapamontol, T (reprint author), Chiang Mai Univ, Res Inst Hlth Sci RIHES, Pollut & Environm Hlth Res Program, POB 80, Chiang Mai 50200, Thailand. EM rhxxo005@chiangmai.ac.th RI Chantara, Somporn/A-1231-2009; Barr, Dana/E-6369-2011; Barr, Dana/E-2276-2013 NR 27 TC 35 Z9 38 U1 0 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD DEC 15 PY 2008 VL 407 IS 1 BP 655 EP 668 DI 10.1016/j.scitotenv.2008.08.044 PG 14 WC Environmental Sciences SC Environmental Sciences & Ecology GA 386IW UT WOS:000261877900062 PM 18954893 ER PT J AU Ford, ES Schulze, MB Pischon, T Bergmann, MM Joost, HG Boeing, H AF Ford, Earl S. Schulze, Matthias B. Pischon, Tobias Bergmann, Manuela M. Joost, Hans-Georg Boeing, Heiner TI Metabolic syndrome and risk of incident diabetes: findings from the European Prospective Investigation into Cancer and Nutrition-Potsdam Study SO CARDIOVASCULAR DIABETOLOGY LA English DT Article ID CORONARY-HEART-DISEASE; CHOLESTEROL EDUCATION-PROGRAM; CARDIOVASCULAR-DISEASE; ALTERNATIVE DEFINITIONS; INSULIN-RESISTANCE; CHINESE POPULATION; EPIC-GERMANY; MELLITUS; FEDERATION; PREDICTION AB Background: Several aspects concerning the relationship between the metabolic syndrome and incident diabetes are incompletely understood including the magnitude of the risk estimate, potential gender differences in the associations between the metabolic syndrome and incident diabetes, the associations between the components of the metabolic syndrome and incident diabetes, and whether the metabolic syndrome provides additional prediction beyond its components. To shed light on these issues, we examined the prospective association between the metabolic syndrome defined by the National Cholesterol Education Program (NCEP) and International Diabetes Federation (IDF) and diabetes. Methods: We used data for 2796 men and women aged 35-65 years from the European Prospective Investigation into Cancer and Nutrition-Potsdam Study followed for an average of 6.9 years. This analysis employed a case-cohort design that included 697 participants who developed diabetes and 2099 participants who did not. Incident diabetes was identified on the basis of self-reports and verified by contacting the patient's attending physician. Results: The adjusted hazard ratio for the NCEP definition was 4.62 (95% confidence interval [CI]: 3.90-5.48) and that for the IDF definition was 4.59 (95% CI: 3.84-5.50). The adjusted hazard ratios for the NCEP but not IDF definition were higher for women than men. When participants who had no cardiometabolic abnormalities were used as the reference group for the NCEP definition, the adjusted hazard ratio for having 3 or more abnormalities increased to 22.50 (95% CI: 11.21-45.19). Of the five components, abdominal obesity and hyperglycemia were most strongly associated with incident diabetes. Conclusion: In this study population, both definitions of the metabolic syndrome provided similar estimates of relative risk for incident diabetes. The increase in risk for participants with the metabolic syndrome according to the NCEP definition was very large when contrasted with the risk among those who had no cardiometabolic abnormalities. C1 [Ford, Earl S.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Schulze, Matthias B.] Tech Univ Munich, Publ Hlth Nutr Unit, Ctr Life & Food Sci, D-8050 Freising Weihenstephan, Germany. [Pischon, Tobias; Bergmann, Manuela M.; Boeing, Heiner] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Potsdam, Nuthetal, Germany. [Joost, Hans-Georg] German Inst Human Nutr Potsdam Rehbrucke, Dept Pharmacol, Potsdam, Nuthetal, Germany. RP Ford, ES (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. EM eford@cdc.gov; matthias.schulze@wzw.tum.de; pischon@dife.de; bergmann@dife.de; joost@dife.de; boeing@dife.de RI Joost, Hans-Georg/J-4462-2013; OI Joost, Hans-Georg/0000-0002-5860-606X; Schulze, Matthias B./0000-0002-0830-5277; Pischon, Tobias/0000-0003-1568-767X NR 30 TC 49 Z9 50 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2840 J9 CARDIOVASC DIABETOL JI Cardiovasc. Diabetol. PD DEC 12 PY 2008 VL 7 AR 35 DI 10.1186/1475-2840-7-35 PG 8 WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism SC Cardiovascular System & Cardiology; Endocrinology & Metabolism GA 407ES UT WOS:000263347000001 PM 19077281 ER PT J AU Rosner, W Vesper, H AF Rosner, William Vesper, Hubert TI CDC workshop report improving steroid hormone measurements in patient care and research translation Preface SO STEROIDS LA English DT Editorial Material C1 [Rosner, William] Columbia Univ, St Lukes Roosevelt Hosp, Dept Med, New York, NY 10019 USA. [Vesper, Hubert] Ctr Dis Control & Prevent, Prot Biomarker Lab, Clin Chem Branch, NCEH DLS, Atlanta, GA 30341 USA. RP Rosner, W (reprint author), Columbia Univ, St Lukes Roosevelt Hosp, Dept Med, 1000 10th Ave, New York, NY 10019 USA. EM wr7@columbia.edu; hav2@cdc.gov NR 0 TC 17 Z9 17 U1 2 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0039-128X J9 STEROIDS JI Steroids PD DEC 12 PY 2008 VL 73 IS 13 SI SI BP 1285 EP 1285 DI 10.1016/j.steroids.2008.08.001 PG 1 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism SC Biochemistry & Molecular Biology; Endocrinology & Metabolism GA 377JJ UT WOS:000261247200001 PM 18755204 ER PT J AU Vesper, HW Botelho, JC Shacklady, C Smith, A Myers, GL AF Vesper, Hubert W. Botelho, Julianne C. Shacklady, Christopher Smith, Antoinette Myers, Gary L. TI CDC project on standardizing steroid hormone measurements SO STEROIDS LA English DT Article; Proceedings Paper CT CDC Workshop on Improving Steroid Hormone Measurements in Patient Care and Research Translation CY MAR 17-18, 2008 CL Atlanta, GA SP Ctr Dis Control, Div Lab Sci DE Estradiol; Testosterone; Standardization; Traceability; Preanalytical component; Postanalytical component ID TANDEM MASS-SPECTROMETRY; CLINICAL-PRACTICE GUIDELINE; SERUM TESTOSTERONE; ADULT MEN; WOMEN; ASSAYS; IMMUNOASSAYS; THERAPY AB Estradiol and testosterone measurements are widely used to assess steroid hormone status and to monitor stimulative, suppressive, or replacement therapy among children and adults of both sexes. Despite their common application, these measurements - particularly at low concentrations - show only limited comparability among assays, such as those observed for testosterone among women or for estradiol among postmenopausal women. This shortcoming hampers progress in research and in research translation. To overcome this, the Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences (CDC/NCEH/DLS) initiated a project to standardize and to improve steroid hormone measurements. The project is a collaborative effort between institutions, organizations, and groups involved in estradiol and testosterone testing, test interpretation, and use. Specific activities are scheduled based on needs assessments conducted with the clinical, research, and public health communities. The initial focus of this standardization project is to improve analytical measurements through reference laboratory activities. As part of the project's translational activities, CDC/NCEH/DLS will work further with professional societies and organizations to improve pre- and postanalytical issues that affect results from these measurements and their interpretation. Published by Elsevier Inc. C1 [Vesper, Hubert W.; Botelho, Julianne C.; Shacklady, Christopher; Smith, Antoinette; Myers, Gary L.] Ctr Dis Control & Prevent, Div Sci Lab, Atlanta, GA 30341 USA. RP Vesper, HW (reprint author), Ctr Dis Control & Prevent, Div Sci Lab, 4770 Buford Hwy NE MS F25, Atlanta, GA 30341 USA. EM HVesper@cdc.gov NR 32 TC 25 Z9 25 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0039-128X J9 STEROIDS JI Steroids PD DEC 12 PY 2008 VL 73 IS 13 SI SI BP 1286 EP 1292 DI 10.1016/j.steroids.2008.09.008 PG 7 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism SC Biochemistry & Molecular Biology; Endocrinology & Metabolism GA 377JJ UT WOS:000261247200002 PM 18834895 ER PT J AU Myers, GL AF Myers, Gary L. TI Introduction to standardization of laboratory results SO STEROIDS LA English DT Article; Proceedings Paper CT CDC Workshop on Improving Steroid Hormone Measurements in Patient Care and Research Translation CY MAR 17-18, 2008 CL Atlanta, GA SP Ctr Dis Control, Div Lab Sci DE Traceability; Standardization; Laboratory improvement ID CREATININE MEASUREMENT; EDUCATION-PROGRAM; SERUM CREATININE; CHOLESTEROL; COMMUTABILITY; IMMUNOASSAYS AB A fundamental goal of laboratory medicine is that laboratory results will be comparable or standardized and be independent of the laboratory where the testing was performed. Routine measurement procedures that are traceable to the same system of reference standards should produce numerical values for clinical samples that are comparable regardless of time, place, or laboratory generating the result. Standardization of laboratory measurements is key to providing accurate and reliable results from investigational studies and for optimal patient care. Published by Elsevier Inc. C1 Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. RP Myers, GL (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway NE F25, Atlanta, GA 30341 USA. EM glm1@cdc.gov NR 17 TC 2 Z9 2 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0039-128X J9 STEROIDS JI Steroids PD DEC 12 PY 2008 VL 73 IS 13 SI SI BP 1293 EP 1296 DI 10.1016/j.steroids.2008.06.012 PG 4 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism SC Biochemistry & Molecular Biology; Endocrinology & Metabolism GA 377JJ UT WOS:000261247200003 PM 18652837 ER PT J AU Bhasin, S Zhang, A Coviello, A Jasuja, R Ulloor, J Singh, R Vesper, H Vasan, RS AF Bhasin, Shalender Zhang, Anqi Coviello, Andrea Jasuja, Ravi Ulloor, Jagadish Singh, Ravinder Vesper, Hubert Vasan, Ramachandran S. TI The impact of assay quality and reference ranges on clinical decision making in the diagnosis of androgen disorders SO STEROIDS LA English DT Article; Proceedings Paper CT CDC Workshop on Improving Steroid Hormone Measurements in Patient Care and Research Translation CY MAR 17-18, 2008 CL Atlanta, GA SP Ctr Dis Control, Div Lab Sci DE Testosterone; Estradiol; Reference limits; Androgen deficiency; Hormone assays ID TANDEM MASS-SPECTROMETRY; FREE TESTOSTERONE; SERUM TESTOSTERONE; ADULT MEN; FUNCTIONAL SENSITIVITY; BOUND TESTOSTERONE; PRACTICE GUIDELINE; REFERENCE VALUES; WOMEN; DEFICIENCY AB The Endocrine Society guideline on Androgen Deficiency in Men emphasized that accurate measurement of testosterone (T) levels is central to the diagnosis of androgen deficiency. Similarly, accurate measurements of testosterone levels are important in the diagnosis of androgen disorders in women and children. However, the accuracy of direct radioimmunoassays for the measurement of total T levels has been questioned, especially ill the low range prevalent in women, children, and androgen deficient men. Furthermore, reference limits for total and free T levels generated in a population-based sample of community dwelling men, women, and children are not available. In the absence of standardized reference limits, the partitioning of total and free T levels into normal, low, or high values is fraught with substantial risk of misclassification. The recommendations for partitioning of individuals into those with low, normal, or high levels should be based on considerations of statistical distribution of total and free T values and the association Of Outcomes with varying degree of deviations from the reference limits. Ongoing efforts to generate population-based reference ranges for total and free testosterone levels ill men and women will provide a framework for the interpretation of serum T levels and enhance the comprehensibility of circulating T values to practicing clinicians. These steps will facilitate the development of rational criteria for the diagnosis of androgen disorders in men, women, and children. (C) 2008 Published by Elsevier Inc. C1 [Bhasin, Shalender] Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston Med Ctr, Boston, MA 02118 USA. [Singh, Ravinder] Mayo Clin, Rochester, MN USA. [Vesper, Hubert] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Bhasin, S (reprint author), Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Boston Med Ctr, 670 Albany St,2nd Floor, Boston, MA 02118 USA. EM bhasin@bu.edu OI Ramachandran, Vasan/0000-0001-7357-5970 FU NIA NIH HHS [1R01AG22356, 1U01AG14369] NR 60 TC 38 Z9 40 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0039-128X J9 STEROIDS JI Steroids PD DEC 12 PY 2008 VL 73 IS 13 SI SI BP 1311 EP 1317 DI 10.1016/j.steroids.2008.07.003 PG 7 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism SC Biochemistry & Molecular Biology; Endocrinology & Metabolism GA 377JJ UT WOS:000261247200006 PM 18687348 ER PT J AU Collins, WE Barnwell, JW AF Collins, William E. Barnwell, John W. TI A Hopeful Beginning for Malaria Vaccines SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Editorial Material ID CIRCUMSPOROZOITE PROTEIN VACCINE; PLASMODIUM-FALCIPARUM INFECTION; EFFICACY; TRIAL; SAFETY; GAMBIA C1 [Collins, William E.; Barnwell, John W.] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis, Atlanta, GA 30333 USA. RP Collins, WE (reprint author), Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis, Atlanta, GA 30333 USA. NR 12 TC 7 Z9 8 U1 0 U2 0 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD DEC 11 PY 2008 VL 359 IS 24 BP 2599 EP 2601 DI 10.1056/NEJMe0808983 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 381KG UT WOS:000261534200013 PM 19064626 ER PT J AU Wheeler, K Kass, D Hoffman, RS Lackovic, M Mitchell, Y Barrett, R Morrissey, B Mehler, L Diebolt-Brown, B Waltz, J Schwartz, A Calvert, GM Luckhaupt, SE AF Wheeler, K. Kass, D. Hoffman, R. S. Lackovic, M. Mitchell, Y. Barrett, R. Morrissey, B. Mehler, L. Diebolt-Brown, B. Waltz, J. Schwartz, A. Calvert, G. M. Luckhaupt, S. E. TI Illnesses and Injuries Related to Total Release Foggers Eight States, 2001-2006 (Reprinted from MMWR, vol 57, pg 1125-1129, 2008) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Wheeler, K.; Kass, D.] New York City Dept Hlth & Mental Hyg, New York, NY 10013 USA. [Hoffman, R. S.] New York City Poison Control Ctr, New York, NY USA. [Lackovic, M.] Louisiana Dept Hlth & Hosp, Baton Rouge, LA 70821 USA. [Mitchell, Y.] New York State Dept Hlth, New York, NY USA. [Barrett, R.] Florida Dept Hlth, Tallahassee, FL 32399 USA. [Morrissey, B.] Washington State Dept Hlth, Olympia, WA USA. [Mehler, L.] Calif Dept Pesticide Regulat, Sacramento, CA USA. [Diebolt-Brown, B.] Texas Dept State Hlth Svcs, Austin, TX USA. [Waltz, J.] Oregon Dept Human Svcs, Salem, OR USA. [Schwartz, A.] Michigan Dept Community Hlth, Lansing, MI USA. [Calvert, G. M.] NIOSH, Div Surveillance Hazard Evaluat & Field Studi, Cincinnati, OH 45226 USA. [Luckhaupt, S. E.] CDC, Atlanta, GA 30333 USA. RP Wheeler, K (reprint author), New York City Dept Hlth & Mental Hyg, New York, NY 10013 USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 10 PY 2008 VL 300 IS 22 BP 2600 EP 2602 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 380YW UT WOS:000261503000009 ER PT J AU Duchin, JS Kwan-Gett, TS McKeirnan, S Grandjean, M Ohrt, M Randels, S Arguin, PM Phares, CR Hanson, MP AF Duchin, J. S. Kwan-Gett, T. S. McKeirnan, S. Grandjean, M. Ohrt, M. Randels, S. Arguin, P. M. Phares, C. R. Hanson, M. P. TI Malaria in Refugees From Tanzania-King County, Washington, 2007 (Reprinted from MMWR, vol 57, pg 869-872, 2008) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint ID PRIMAQUINE C1 [Duchin, J. S.; Kwan-Gett, T. S.; McKeirnan, S.; Grandjean, M.; Ohrt, M.; Randels, S.] Seattle King Cty Dept Publ Hlth, Communicable Dis Epidemiol & Immunizat Sect, Seattle, WA 98104 USA. [Arguin, P. M.] Natl Ctr Zoonot Vectorborne & Enter Dis, Malaria Branch, Div Parasit Dis, Atlanta, GA USA. [Phares, C. R.] Natl Ctr Preparedness Detect & Control Infect Dis, Immigrant Refugee & Migrant Hlth Branch, Div Global Migrat & Quarantine, Atlanta, GA USA. [Hanson, M. P.] CDC, Atlanta, GA 30333 USA. RP Duchin, JS (reprint author), Seattle King Cty Dept Publ Hlth, Communicable Dis Epidemiol & Immunizat Sect, Seattle, WA 98104 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 10 PY 2008 VL 300 IS 22 BP 2602 EP 2604 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 380YW UT WOS:000261503000010 ER PT J AU Hall, AJ Logan, JE Toblin, RL Kaplan, JA Kraner, JC Bixler, D Crosby, AE Paulozzi, LJ AF Hall, Aron J. Logan, Joseph E. Toblin, Robin L. Kaplan, James A. Kraner, James C. Bixler, Danae Crosby, Alex E. Paulozzi, Leonard J. TI Patterns of Abuse Among Unintentional Pharmaceutical Overdose Fatalities SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID UNITED-STATES; OPIOID ANALGESICS; CHRONIC PAIN; DEATHS AB Context Use and abuse of prescription narcotic analgesics have increased dramatically in the United States since 1990. The effect of this pharmacoepidemic has been most pronounced in rural states, including West Virginia, which experienced the nation's largest increase in drug overdose mortality rates during 1999- 2004. Objective To evaluate the risk characteristics of persons dying of unintentional pharmaceutical overdose in West Virginia, the types of drugs involved, and the role of drug abuse in the deaths. Design, Setting, and Participants Population- based, observational study using data from medical examiner, prescription drug monitoring program, and opiate treatment program records. The study population was all state residents who died of unintentional pharmaceutical overdoses in West Virginia in 2006. Main Outcome Measures Rates and rate ratios for selected demographic variables. Prevalence of specific drugs among decedents and proportion that had been prescribed to decedents. Associations between demographics and substance abuse indicators and evidence of pharmaceutical diversion, defined as a death involving a prescription drug without a documented prescription and having received prescriptions for controlled substances from 5 or more clinicians during the year prior to death ( ie, doctor shopping). Results Of 295 decedents, 198 ( 67.1%) were men and 271 ( 91.9%) were aged 18 through 54 years. Pharmaceutical diversion was associated with 186 ( 63.1%) deaths, while 63 ( 21.4%) were accompanied by evidence of doctor shopping. Prevalence of diversion was greatest among decedents aged 18 through 24 years and decreased across each successive age group. Having prescriptions for a controlled substance from 5 or more clinicians in the year prior to death was more common among women (30 [ 30.9%]) and decedents aged 35 through 44 years ( 23 [ 30.7%]) compared with men ( 33 [ 16.7%]) and other age groups ( 40 [ 18.2%]). Substance abuse indicators were identified in 279 decedents ( 94.6%), with nonmedical routes of exposure and illicit contributory drugs particularly prevalent among drug diverters. Multiple contributory substances were implicated in 234 deaths ( 79.3%). Opioid analgesics were taken by 275 decedents (93.2%), of whom only 122 ( 44.4%) had ever been prescribed these drugs. Conclusion The majority of overdose deaths in West Virginia in 2006 were associated with nonmedical use and diversion of pharmaceuticals, primarily opioid analgesics. C1 [Hall, Aron J.; Logan, Joseph E.; Toblin, Robin L.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Logan, Joseph E.; Toblin, Robin L.; Crosby, Alex E.; Paulozzi, Leonard J.] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA. [Hall, Aron J.; Bixler, Danae] W Virginia Dept Hlth & Human Resources, Div Surveillance & Dis Control, Charleston, WV USA. [Kaplan, James A.; Kraner, James C.] W Virginia Dept Hlth & Human Resources, Off Chief Med Examiner, Charleston, WV USA. RP Hall, AJ (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv, 1600 Clifton Rd NE,Mailstop A-47, Atlanta, GA 30333 USA. EM ajhall@cdc.gov NR 29 TC 384 Z9 389 U1 6 U2 16 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 10 PY 2008 VL 300 IS 22 BP 2613 EP 2620 DI 10.1001/jama.2008.802 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 380YW UT WOS:000261503000020 PM 19066381 ER PT J AU Jiang, BM Gentsch, JR Glass, RI AF Jiang, Baoming Gentsch, Jon R. Glass, Roger I. TI Inactivated rotavirus vaccines: A priority for accelerated vaccine development SO VACCINE LA English DT Review DE Rotavirus; Vaccine; Parenteral; Intussusception ID VIRUS-LIKE PARTICLES; PROTECTIVE IMMUNITY; GNOTOBIOTIC PIGS; INTRAMUSCULAR IMMUNIZATION; ANTIBODIES; MICE; GASTROENTERITIS; IMMUNOGENICITY; EFFICACY; SAFETY AB Live oral rotavirus vaccines have proven to be generally safe and effective to prevent severe dehydrating diarrhea among children in high and some middle income countries. However, concerns linger about rare but severe adverse events, Such as intussusception and their efficacy against the full range of rotavirus serotypes. More importantly, live oral vaccines have been less immunogenic and results of trails to assess their efficacy in poor children of both Africa and Asia will not be available for 2-3 years. This review describes the rationale for developing an inactivated rotavirus vaccine (IRV) as ail alternative approach should live oral vaccines not work well in these challenging populations. Studies have demonstrated the protective role of serum antibody in animals and children and the robust serum antibody response and protection against rotavirus infection in animal models following parenteral immunization with IRV. Four years after licensing the first new generation of rotavirus vaccine, we still remain several years away from knowing how well they work in the target populations. Research to develop alternative approaches should be fostered as an insurance policy to protect against suboptimal efficacy of Unanticipated adverse events that Could hinder global immunization and protection of all children. Published by Elsevier Ltd. C1 [Jiang, Baoming; Gentsch, Jon R.; Glass, Roger I.] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA. [Glass, Roger I.] NIH, Fogarty Int Ctr, Bethesda, MD USA. RP Jiang, BM (reprint author), Natl Ctr Immunizat & Resp Dis, Gastroenteritis & Resp Viruses Lab Branch, Mailstop G04,1600 Clifton Rd, Atlanta, GA 30333 USA. EM bxj4@cdc.gov NR 38 TC 32 Z9 36 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD DEC 9 PY 2008 VL 26 IS 52 BP 6754 EP 6758 DI 10.1016/j.vaccine.2008.10.008 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 386QT UT WOS:000261898400007 PM 18951937 ER PT J AU Gidudu, J Kohl, KS Halperin, S Harnmer, SJ Heath, PT Hennig, R Hoet, B Rothstein, E Schuind, A Varricchioi, F Walop, W AF Gidudu, Jane Kohl, Katrin S. Halperin, Scott Harnmer, Sandra Jo Heath, Paul T. Hennig, Renald Hoet, Bernard Rothstein, Edward Schuind, Anne Varricchioi, Frederick Walop, Wikke CA A Local Reaction near Injection TI A local reaction at or near injection site: Case definition and guidelines for collection, analysis, and presentation of immunization safety data SO VACCINE LA English DT Article DE A local reaction; Adverse event; Immunization; Guidelines; Case definition ID ACELLULAR PERTUSSIS-VACCINE; BCG VACCINATION; CONJUGATE VACCINE; DIPHTHERIA; TETANUS; INFANTS; IMMUNOGENICITY; REACTOGENICITY; METAANALYSIS; STATEMENT AB The need for developing a case definition and guidelines for a local reaction at or near the injection site, methods for the development of the case definition and guidelines as an adverse event following immunization as well as the rationale for selected decisions about the case definition for a local reaction at or near the injection site are explained in the Preamble section. The case definition is structured in 2 levels of diagnostic certainty: level I includes any description of morphological OF physiological change at OF near the injection site that is described or identified by a healthcare provider. Level 2 is any description of morphological or physiological change at or near injection site that is described by any other person. In Guidelines section, the working group recommends to enable meaningful and standardized data collection, analysis, and presentation of information about a local reaction at or near the injection site. However, implementation of all guidelines might not be possible in all settings. The availability of information may vary depending upon resources, geographic region, and whether the Source of information is a prospectively designed clinical trial, a post-marketing surveillance or epidemiologic study, or ail individual report of a local reaction at injection site. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Gidudu, Jane; Kohl, Katrin S.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Halperin, Scott] Dalhousie Univ, Halifax, NS, Canada. [Harnmer, Sandra Jo] Calif Dept Publ Hlth, Richmond, CA USA. [Heath, Paul T.] St Georges Univ, London, England. [Hennig, Renald] Scratch GbR, Pharmacovigilance Serv, Butzbach, Germany. [Hoet, Bernard] GlaxoSmithKline Biol, Rixensart, Belgium. [Rothstein, Edward] Pennridge Pediat Associates, Sellersville, PA USA. [Schuind, Anne] GlaxoSmithKline Inc, King Of Prussia, PA USA. [Varricchioi, Frederick] US FDA, Rockville, MD 20857 USA. [Walop, Wikke] Publ Hlth Agcy Canada, Ottawa, ON, Canada. RP Gidudu, J (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop D-26, Atlanta, GA 30333 USA. EM secretariat@brightoncollaboration.org FU Brighton Collaboration Steering Committee FX The authors are grateful for the support and helpful comments from members of the Brighton Collaboration Steering Committee (S. Michael Marcy, Ulrich Heininger, Miles Braun, Brigitte Keller Stanislawski, Michael Blum, and Odile Leroy), and participants in the Reference Group: Jose-Maria Bayas, Silvia Berardi, Arthur Brown, Gayle Burns, Daniela Burroni, Arani Chatterjee, Christopher da Costa, Iris de Bruijn, Jean-Luc Grenier, Mathew Hohenboken, John Iskander, Lisajackson, Ali Khamesipour, Alasdair King, Andrew Kroger, Dale N Lawrence, David Nalin, Thomas Nisslein, Hanne Nokleby,James M Oleske, Francoise Sillan, Robert Sparks, Lina Tao, Anna Vilella, Beverly Warden, Virginia Wong, Giovanna Zanoni, and juergen Zorn as well as the medical illustrator Patty Chen, the Brighton General Manager April Compingbutra for her help with the working group, and Onnalee Gomez for conducting the literature searches. NR 46 TC 22 Z9 22 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD DEC 9 PY 2008 VL 26 IS 52 BP 6800 EP 6813 DI 10.1016/j.vaccine.2008.10.006 PG 14 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 386QT UT WOS:000261898400013 PM 18950670 ER PT J AU Engler, RJM Nelson, MR Klote, MM VanRaden, MJ Huang, CY Cox, NJ Klimov, A Keitel, WA Nichol, KL Carr, WW Treanor, JJ AF Engler, Renata J. M. Nelson, Michael R. Klote, Mary M. VanRaden, Mark J. Huang, Chiung-Yu Cox, Nancy J. Klimov, Alexander Keitel, Wendy A. Nichol, Kristin L. Carr, Warner W. Treanor, John J. CA Walter Reed Hlth Care Syst Influen TI Half- vs Full-Dose Trivalent Inactivated Influenza Vaccine (2004-2005) Age, Dose, and Sex Effects on Immune Responses SO ARCHIVES OF INTERNAL MEDICINE LA English DT Article ID HEALTH-CARE WORKERS; RANDOMIZED CONTROLLED-TRIAL; LONG-TERM-CARE; ANTIBODY-RESPONSES; COST-EFFECTIVENESS; ELDERLY PERSONS; WORKING ADULTS; VIRUS; SERUM; MORTALITY AB Background: Optimal public health strategies for managing influenza vaccine shortages are not yet defined. Our objective was to determine the effects of age, sex, and dose on the immunogenicity of intramuscular trivalent inactivated vaccine (TIV). Methods: Healthy adults aged 18 to 64 years, stratified by age (18-49 and 50-64 years) and sex, were randomized to receive full- or half-dose TIV. Hemagglutination inhibition titers against vaccine antigens were measured before and 21 days after immunization. A primary outcome of noninferiority was defined as a difference of less than 20% in the upper 95% confidence interval (CI) of the proportion of subjects with strain-specific hemagglutination inhibition antibody titers of 1:40 or higher after vaccination. Secondary outcomes included geometric mean titers, after vaccination side effects, and occurrences of influenza-like illnesses. Results: Among previously immunized subjects (N=1114) receiving half- vs full-dose TIV (age, 18-49 years, n=284 [half] and n=274 [full]; and age 50-64 years, n=276 [half] and n=280 [full]), CIs for proportions of subjects with hemagglutination inhibition antibody titers of 1:40 or higher excluded substantial reduction for all antigens in the 18- to 49-year age group and for B/Shanghai/361/2002 (B) and A/Fujian/411/2002 (A/H3N2) in the 50- to 64-year age group. Geometric mean titer in the female 18- to 49-year age group exceeded male responses for all strains: responses to half- dose TIV that were comparable with male full- dose responses for A/ New Caledonia/20/99 (A/H1N1) antigen, 25.4 (95% CI, 20.9-30.9) vs 25.6 (95% CI, 21.3-30.9); A/H3N2 antigen, 60.8 (95% CI, 50.8-72.7) vs 44.1 (95% CI, 37.6-51.8); and B antigen, 64.4 (95% CI, 53.9-76.9) vs 60.7 (95% CI, 51.4-71.7) (findings were similar for the 50- to 64- year age group). Some injection site and systemic reactions (myalgias and/or arthralgias [P<.05], headache [P<.001], and impact of fatigue [P<.05]) were significantly lower in men. The relative risk of medical visits and hospitalizations for influenza-like illnesses were similar in the half- and full- dose groups regardless of age. Conclusions: Antibody responses to intramuscular half-dose TIV in healthy, previously immunized adults were not substantially inferior to the full- dose vaccine, particularly for ages 18 to 49 years. Significantly higher geometric mean titer responses in women were identified for all ages, regardless of dose or influenza strain. Half-dose vaccination may be an effective strategy for healthy adults younger than 50 years in the setting of an influenza vaccine shortage. Trial Registration: clinicaltrials.gov Identifier: NCT00283283 C1 [Engler, Renata J. M.] Walter Reed Army Med Ctr, Vaccine Healthcare Ctr Network, Allergy Immunol Dept, Washington, DC 20307 USA. [VanRaden, Mark J.; Huang, Chiung-Yu] NIAID, NIH, Bethesda, MD 20892 USA. [Cox, Nancy J.; Klimov, Alexander] Ctr Dis Control & Prevent, Influenza Branch, Atlanta, GA USA. [Keitel, Wendy A.] Baylor Coll Med, Houston, TX 77030 USA. [Nichol, Kristin L.] Univ Minnesota, Sch Med, VA Med Ctr, Minneapolis, MN 55455 USA. [Nichol, Kristin L.] Univ Minnesota, Sch Med, Dept Med, Minneapolis, MN 55455 USA. [Treanor, John J.] Univ Rochester, Dept Med, Infect Dis Unit, Rochester, NY USA. RP Engler, RJM (reprint author), Walter Reed Army Med Ctr, Vaccine Healthcare Ctr Network, Allergy Immunol Dept, 6900 Georgia Ave NW,Bldg 41,Ste 21, Washington, DC 20307 USA. EM renata.engler@gmail.com FU Office of the Army Surgeon General in collaboration with Walter Reed Army Medical Center(WRAMC); Healthcare System; North Atlantic Regional Medical Command; US Army Medical Research and Materiel Command; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Influenza Branch of the Centers for Disease Control and Prevention FX This study was supported by the Office of the Army Surgeon General in collaboration with Walter Reed Army Medical Center(WRAMC) and Healthcare System; the North Atlantic Regional Medical Command; the US Army Medical Research and Materiel Command; the National Institute of Allergy and Infectious Diseases, National Institutes of Health; and the Influenza Branch of the Centers for Disease Control and Prevention. NR 34 TC 69 Z9 69 U1 0 U2 6 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD DEC 8 PY 2008 VL 168 IS 22 BP 2405 EP 2414 DI 10.1001/archinternmed.2008.513 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA 380SX UT WOS:000261486600004 PM 19064822 ER PT J AU Yu, W Wulf, A Liu, TB Khoury, MJ Gwinn, M AF Yu, Wei Wulf, Anja Liu, Tiebin Khoury, Muin J. Gwinn, Marta TI Gene Prospector: An evidence gateway for evaluating potential susceptibility genes and interacting risk factors for human diseases SO BMC BIOINFORMATICS LA English DT Article ID HUMAN GENOME EPIDEMIOLOGY; CANDIDATE GENE; ASSOCIATION; DATABASE; SUPPORT AB Background: Millions of single nucleotide polymorphisms have been identified as a result of the human genome project and the rapid advance of high throughput genotyping technology. Genetic association studies, such as recent genome-wide association studies (GWAS), have provided a springboard for exploring the contribution of inherited genetic variation and gene/environment interactions in relation to disease. Given the capacity of such studies to produce a plethora of information that may then be described in a number of publications, selecting possible disease susceptibility genes and identifying related modifiable risk factors is a major challenge. A Web-based application for finding evidence of such relationships is key to the development of follow-up studies and evidence for translational research. We developed a Web-based application that selects and prioritizes potential disease-related genes by using a highly curated and updated literature database of genetic association studies. The application, called Gene Prospector, also provides a comprehensive set of links to additional data sources. Results: We compared Gene Prospector results for the query "Parkinson" with a list of 13 leading candidate genes ( Top Results) from a curated, specialty database for genetic associations with Parkinson disease (PDGene). Nine of the thirteen leading candidate genes from PDGene were in the top 10th percentile of the ranked list from Gene Prospector. In fact, Gene Prospector included more published genetic association studies for the 13 leading candidate genes than PDGene did. Conclusion: Gene Prospector provides an online gateway for searching for evidence about human genes in relation to diseases, other phenotypes, and risk factors, and provides links to published literature and other online data sources. Gene Prospector can be accessed via http://www.hugenavigator.net/HuGENavigator/geneProspectorStartPage.do. C1 [Yu, Wei; Wulf, Anja; Liu, Tiebin; Khoury, Muin J.; Gwinn, Marta] Ctr Dis Control & Prevent, Natl Off Publ Hlth, Coordinating Ctr Hlth Promot, Atlanta, GA USA. RP Yu, W (reprint author), Ctr Dis Control & Prevent, Natl Off Publ Hlth, Coordinating Ctr Hlth Promot, Atlanta, GA USA. EM WYu@cdc.gov; AWulf@cdc.gov; TLiu@cdc.gov; MKhoury@cdc.gov; MGwinn@cdc.gov NR 27 TC 39 Z9 40 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2105 J9 BMC BIOINFORMATICS JI BMC Bioinformatics PD DEC 8 PY 2008 VL 9 AR 528 DI 10.1186/1471-2105-9-528 PG 8 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Mathematical & Computational Biology GA 402FH UT WOS:000262999100003 PM 19063745 ER PT J AU Glaser, C Schuster, F Yagi, S Gavali, S Bollen, A Glastonbury, C Raghavan, R Michelson, D Blomquist, I Scharnhorst, D Kuriyama, S Reed, S Ginsberg, M Visvesvara, G Wilkins, P Anderson, L Khetsuriani, N Fowlkes, AL AF Glaser, C. Schuster, F. Yagi, S. Gavali, S. Bollen, A. Glastonbury, C. Raghavan, R. Michelson, D. Blomquist, I. Scharnhorst, D. Kuriyama, S. Reed, S. Ginsberg, M. Visvesvara, G. Wilkins, P. Anderson, L. Khetsuriani, N. Fowlkes, A. L. TI Balamuthia Amebic Encephalitis-California, 1999-2007 (Reprinted from MMWR, vol 57, pg 768-771, 2008) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint ID MENINGOENCEPHALITIS; MANDRILLARIS; AGENT; ANIMALS; HUMANS C1 [Glaser, C.; Schuster, F.; Yagi, S.; Gavali, S.] Calif Dept Publ Hlth, Viral & Rickettsial Dis Lab, San Francisco, CA USA. [Bollen, A.] Univ Calif San Francisco, Med Ctr, Dept Pathol, San Francisco, CA 94143 USA. [Glastonbury, C.] Univ Calif San Francisco, Med Ctr, Dept Radiol, San Francisco, CA 94143 USA. [Raghavan, R.; Michelson, D.; Blomquist, I.] Loma Linda Childrens Hosp, Loma Linda, CA USA. [Scharnhorst, D.; Fowlkes, A. L.] Childrens Hosp Cent Calif, Madera, CA USA. [Kuriyama, S.; Reed, S.] Univ Calif San Diego, Med Ctr, San Diego, CA 92103 USA. [Ginsberg, M.] San Diego Cty Hlth Dept, San Diego, CA USA. [Visvesvara, G.; Wilkins, P.] CDC, Div Parasit Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Anderson, L.; Khetsuriani, N.; Fowlkes, A. L.] CDC, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Glaser, C (reprint author), Calif Dept Publ Hlth, Viral & Rickettsial Dis Lab, San Francisco, CA USA. NR 11 TC 0 Z9 0 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 3 PY 2008 VL 300 IS 21 BP 2477 EP 2479 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 377XR UT WOS:000261286200006 ER PT J AU Cierpich, H Styles, L Harrison, R Davis, L Chester, D Lefkowitz, D Valiante, D Richardson, S Castillo, D Romano, N Baron, S AF Cierpich, H. Styles, L. Harrison, R. Davis, L. Chester, D. Lefkowitz, D. Valiante, D. Richardson, S. Castillo, D. Romano, N. Baron, S. TI Work-Related Injury Deaths Among Hispanics-United States, 1992-2006 (Reprinted from MMWR, vol 57, pg 597-600, 2008) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Cierpich, H.; Styles, L.] Inst Publ Hlth, Oakland, CA USA. [Harrison, R.] Calif Dept Publ Hlth, Occupat Hlth Br, San Francisco, CA USA. [Davis, L.] Massachusetts Dept Publ Hlth, Occupat Surveillance Program, Boston, MA 02111 USA. [Chester, D.] Michigan State Univ, E Lansing, MI 48824 USA. [Lefkowitz, D.; Valiante, D.] New Jersey Dept Hlth & Sr Svcs, Trenton, NJ USA. [Richardson, S.] US Bur Labor Stat, US Dept Labor, Washington, DC 20212 USA. [Castillo, D.; Romano, N.; Baron, S.] NIOSH, CDC, Atlanta, GA 30333 USA. RP Cierpich, H (reprint author), Inst Publ Hlth, Oakland, CA USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 3 PY 2008 VL 300 IS 21 BP 2479 EP 2480 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 377XR UT WOS:000261286200007 ER PT J AU Yeung, L Yang, QH Berry, RJ AF Yeung, Lorraine Yang, Quanhe Berry, R. J. TI Contributions of Total Daily Intake of Folic Acid to Serum Folate Concentrations SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter ID FORTIFICATION; AGE C1 [Yeung, Lorraine; Berry, R. J.] Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Yang, Quanhe] Ctr Dis Control & Prevent, Natl Off Publ Hlth Genom, Atlanta, GA USA. RP Yeung, L (reprint author), Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. EM rjberry@cdc.gov OI Berry, Robert/0000-0002-7162-5046 NR 6 TC 25 Z9 25 U1 0 U2 4 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 3 PY 2008 VL 300 IS 21 BP 2486 EP 2487 DI 10.1001/jama.2008.742 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 377XR UT WOS:000261286200016 PM 19050191 ER PT J AU Choi, H Sell, RL Lenert, L Muennig, P Goodman, RR Gilliam, FG Wong, JB AF Choi, Hyunmi Sell, Randall L. Lenert, Leslie Muennig, Peter Goodman, Robert R. Gilliam, Frank G. Wong, John B. TI Epilepsy Surgery for Pharmacoresistant Temporal Lobe Epilepsy A Decision Analysis SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID MEDICALLY REFRACTORY EPILEPSY; SUDDEN UNEXPECTED DEATH; QUALITY-OF-LIFE; SURGICAL INTERVENTION; INTRACTABLE EPILEPSY; NERVE-STIMULATION; CONTROLLED-TRIAL; SEIZURE CONTROL; RISK-FACTOR; LOBECTOMY AB Context Patients with pharmacoresistant epilepsy have increased mortality compared with the general population, but patients with pharmacoresistant temporal lobe epilepsy who meet criteria for surgery and who become seizure- free after anterior temporal lobe resection have reduced excess mortality vs those with persistent seizures. Objective To quantify the potential survival benefit of anterior temporal lobe resection for patients with pharmacoresistant temporal lobe epilepsy vs continued medical management. Design Monte Carlo simulation model that incorporates possible surgical complications and seizure status, with 10 000 runs. The model was populated with health-related quality- of- life data obtained directly from patients and data from the medical literature. Insufficient data were available to assess gamma- knife radiosurgery or vagal nerve stimulation. Main Outcome Measures Life expectancy and quality- adjusted life expectancy. Results Compared with medical management, anterior temporal lobe resection for a 35- year- old patient with an epileptogenic zone identified in the anterior temporal lobe would increase survival by 5.0 years ( 95% CI, 2.1- 9.2) with surgery preferred in 100% of the simulations. Anterior temporal lobe resection would increase qualityadjusted life expectancy by 7.5 quality- adjusted life- years ( 95%, CI, - 0.8 to 17.4) with surgery preferred in 96.5% of the simulations, primarily due to increased years spent without disabling seizures, thereby reducing seizure- related excess mortality and improving quality of life. The results were robust to sensitivity analyses. Conclusion The decision analysis model suggests that on average anterior temporal lobe resection should provide substantial gains in life expectancy and qualityadjusted life expectancy for surgically eligible patients with pharmacoresistant temporal lobe epilepsy compared with medical management. C1 [Choi, Hyunmi; Gilliam, Frank G.] Columbia Univ, Dept Neurol, New York, NY USA. [Goodman, Robert R.] Columbia Univ, Dept Neurol Surg, New York, NY USA. [Muennig, Peter] Columbia Univ, Mailman Sch Publ Hlth, Dept Hlth Policy & Management, New York, NY USA. [Sell, Randall L.] Drexel Univ, Sch Publ Hlth, Dept Community Hlth & Prevent, Philadelphia, PA 19104 USA. [Lenert, Leslie] Ctr Dis Control & Prevent, Natl Ctr Publ Hlth Informat, Atlanta, GA USA. [Wong, John B.] Tufts Univ, Sch Med, Dept Med, Div Clin Decis Making,Tufts Med Ctr, Boston, MA 02111 USA. RP Choi, H (reprint author), Neurol Inst, Columbia Comprehens Epilepsy Ctr, 710 W 168Th St,Box 210, New York, NY 10032 USA. EM hc323@columbia.edu OI Muennig, Peter/0000-0002-4234-0498 FU National Center for Research Resources [KL2 RR024157] FX This publication was made possible by grant KL2 RR024157 (Dr Choi) from the National Center for Research Resources, a component of the National Institutes of Health, and NIH Roadmap for Medical Research. NR 68 TC 73 Z9 77 U1 0 U2 4 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 3 PY 2008 VL 300 IS 21 BP 2497 EP 2505 DI 10.1001/jama.2008.771 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 377XR UT WOS:000261286200018 PM 19050193 ER PT J AU Jemal, A Thun, MJ Ries, LAG Howe, HL Weir, HK Center, MM Ward, E Wu, XC Eheman, C Anderson, R Ajani, UA Kohler, B Edwards, BK AF Jemal, Ahmedin Thun, Michael J. Ries, Lynn A. G. Howe, Holly L. Weir, Hannah K. Center, Melissa M. Ward, Elizabeth Wu, Xiao-Cheng Eheman, Christie Anderson, Robert Ajani, Umed A. Kohler, Betsy Edwards, Brenda K. TI Annual Report to the Nation on the Status of Cancer, 1975-2005, Featuring Trends in Lung Cancer, Tobacco Use, and Tobacco Control SO JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Review ID RANDOMIZED CONTROLLED-TRIAL; UNITED-STATES; BREAST-CANCER; COLORECTAL-CANCER; CONTROL PROGRAMS; SMOKING-CESSATION; INCIDENCE RATES; ADULT SMOKERS; SCREENING MAMMOGRAPHY; ENDOMETRIAL CANCER AB The American Cancer Society, the Centers for Disease Control and Prevention (CDC), the National Cancer Institute (NCI), and the North American Association of Central Cancer Registries (NAACCR) collaborate annually to provide updated information on cancer occurrence and trends in the United States. This year's report includes trends in lung cancer incidence and death rates, tobacco use, and tobacco control by state of residence. Information on invasive cancers was obtained from the NCI, CDC, and NAACCR and information on mortality from the CDC's National Center for Health Statistics. Annual percentage changes in the age-standardized incidence and death rates (2000 US population standard) for all cancers combined and for the top 15 cancers were estimated by joinpoint analysis of long-term (1975-2005) trends and by least squares linear regression of short-term (1996-2005) trends. All statistical tests were two-sided. Both incidence and death rates from all cancers combined decreased statistically significantly (P < .05) in men and women overall and in most racial and ethnic populations. These decreases were driven largely by declines in both incidence and death rates for the three most common cancers in men (lung, colorectum, and prostate) and for two of the three leading cancers in women (breast and colorectum), combined with a leveling off of lung cancer death rates in women. Although the national trend in female lung cancer death rates has stabilized since 2003, after increasing for several decades, there is prominent state and regional variation. Lung cancer incidence and/or death rates among women increased in 18 states, 16 of them in the South or Midwest, where, on average, the prevalence of smoking was higher and the annual percentage decrease in current smoking among adult women was lower than in the West and Northeast. California was the only state with decreasing lung cancer incidence and death rates in women. Although the decrease in overall cancer incidence and death rates is encouraging, large state and regional differences in lung cancer trends among women underscore the need to maintain and strengthen many state tobacco control programs. C1 [Jemal, Ahmedin; Thun, Michael J.; Center, Melissa M.; Ward, Elizabeth] Amer Canc Soc, Epidemiol & Surveillance Res Dept, Atlanta, GA 30303 USA. [Weir, Hannah K.; Eheman, Christie; Ajani, Umed A.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Canc Prevent & Control, Atlanta, GA USA. [Anderson, Robert] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Div Vital Stat, Hyattsville, MD 20782 USA. [Ries, Lynn A. G.; Edwards, Brenda K.] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. [Howe, Holly L.; Wu, Xiao-Cheng; Kohler, Betsy] N Amer Assoc Cent Canc Registries, Springfield, IL USA. [Wu, Xiao-Cheng] Louisiana State Univ, Hlth Sci Ctr, New Orleans, LA USA. [Kohler, Betsy] Canc Epidemiol Serv, New Jersey Dept Hlth & Senior Serv, Trenton, NJ USA. RP Jemal, A (reprint author), Amer Canc Soc, Epidemiol & Surveillance Res Dept, 250 Williams St,NW,6D 206, Atlanta, GA 30303 USA. EM ajemal@cancer.org FU American Cancer Society FX The American Cancer Society, the National Cancer Institute, the centers for Disease control and prevention and the North American Association of Central Cancer registries. Funding to pay for the open Access publication charges for the article - was provided by the American Cancer Society. NR 108 TC 523 Z9 551 U1 4 U2 54 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0027-8874 J9 J NATL CANCER I JI J. Natl. Cancer Inst. PD DEC 3 PY 2008 VL 100 IS 23 BP 1672 EP 1694 DI 10.1093/jnci/djn389 PG 23 WC Oncology SC Oncology GA 380JQ UT WOS:000261462400008 PM 19033571 ER PT J AU Lima-Junior, JC Tran, TM Meyer, EVS Singh, B De-Simone, SG Santos, F Daniel-Ribeiro, CT Moreno, A Barnwell, JW Galinski, MR Oliveira-Ferreira, J AF Lima-Junior, J. C. Tran, T. M. Meyer, E. V. S. Singh, B. De-Simone, S. G. Santos, F. Daniel-Ribeiro, C. T. Moreno, A. Barnwell, J. W. Galinski, M. R. Oliveira-Ferreira, J. TI Naturally acquired humoral and cellular immune responses to Plasmodium vivax merozoite surface protein 9 in Northwestern Amazon individuals SO VACCINE LA English DT Article DE Plasmodium vivax; Malaria; Vaccine; Merozoite surface protein 9 ID DUFFY-BINDING-PROTEIN; UNSTABLE MALARIA TRANSMISSION; APICAL MEMBRANE ANTIGEN-1; C-TERMINAL REGIONS; ANTIBODY-RESPONSE; BRAZILIAN AMAZON; T-CELLS; SERUM ANTIBODIES; FALCIPARUM; INFECTION AB Antibody and T-cell reactivities to Plasmodium vivax merozoite Surface protein 9 (PvMSP9) were evaluated in a cross-sectional study of individuals naturally exposed to malaria infections living in Ribeirinha, a native riverine community and in Colina, a transmigrant community, Rondonia, Brazil. I-lie antibody responses to PvMSP9-RlRII and PvMSP9-Nt domains in Ribeirinha were higher compared with Colina and correlated with age and time of malaria exposure. IgG2 was most prevalent for PvMSP9-RII in both communities, and IgGl was the predominant isotype For PvMSP9-Nt and PvMSP9-RlRII in Ribeirinha. IFN-gamma and IL-4 predominated in Ribeirinha, while IFN-gamma predominated ill Colina. Variation ill exposure to 11 vivax likely accounts for the differences observed in cytokine and antibody levels between the two population Studied. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Lima-Junior, J. C.; Daniel-Ribeiro, C. T.; Oliveira-Ferreira, J.] Fiocruz MS, Inst Oswaldo Cruz, Malaria Res Lab, BR-21045900 Rio De Janeiro, Brazil. [Tran, T. M.; Meyer, E. V. S.; Singh, B.; Moreno, A.; Galinski, M. R.] Emory Univ, Emory Vaccine Ctr, Yerkes Natl Primate Res Ctr, Atlanta, GA 30322 USA. [De-Simone, S. G.] Fiocruz MS, Inst Oswaldo Cruz, Lab Biochem Prot & Peptides, BR-21045900 Rio De Janeiro, Brazil. [De-Simone, S. G.] Univ Fed Fluminense, Inst Biol, Dept Biochem & Mol Biol, Rio De Janeiro, Brazil. [Santos, F.] LACEN, Dept Entomol, Porto Velho, RO, Brazil. [Barnwell, J. W.] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA. [Moreno, A.; Galinski, M. R.] Emory Univ, Sch Med, Div Infect Dis, Atlanta, GA USA. RP Oliveira-Ferreira, J (reprint author), Fiocruz MS, Inst Oswaldo Cruz, Malaria Res Lab, 5th Floor,Av Brasil 4365, BR-21045900 Rio De Janeiro, Brazil. EM lila@ioc.fiocruz.br RI Lima-Junior, Josue /B-1361-2014; Oliveira-Ferreira, Joseli/E-7942-2014; OI Lima-Junior, Josue /0000-0002-5848-404X; Oliveira-Ferreira, Joseli/0000-0002-6063-465X; De-Simone, Salvatore/0000-0002-2172-656X FU Brazilian National Research Council - CNPq; Fiocruz; National Institute of Health [RO1 AI0555994]; Yerkes Regional Primate Research Center Base FX This work was supported by Brazilian National Research Council - CNPq, Fiocruz, National Institute of Health, Grant RO1 AI0555994 and the Yerkes Regional Primate Research Center Base Grant. Josue da Costa Lima junior was the recipient of a CNPq Fellowship. NR 53 TC 22 Z9 22 U1 1 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD DEC 2 PY 2008 VL 26 IS 51 BP 6645 EP 6654 DI 10.1016/j.vaccine.2008.09.029 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 386GI UT WOS:000261869900022 PM 18832003 ER PT J AU Pappas-DeLuca, KA Kraft, JM Galavotti, C Warner, L Mooki, M Hastings, P Koppenhaver, T Roels, TH Kilmarx, PH AF Pappas-DeLuca, Katina A. Kraft, Joan Marie Galavotti, Christine Warner, Lee Mooki, Maungo Hastings, Phil Koppenhaver, Todd Roels, Thierry H. Kilmarx, Peter H. TI ENTERTAINMENT-EDUCATION RADIO SERIAL DRAMA AND OUTCOMES RELATED TO HIV TESTING IN BOTSWANA SO AIDS EDUCATION AND PREVENTION LA English DT Article ID TO-CHILD TRANSMISSION; PARASOCIAL INTERACTION; DISCORDANT COUPLES; SEXUAL-BEHAVIOR; PREGNANT-WOMEN; ROLE-MODELS; HIV/AIDS; ATTITUDES; AFRICA; HEALTH AB Makgabaneng is an entertainment-education radio serial drama written and produced in Botswana to promote prevention of HIV. This effort is part of the national response to HIV/AIDS. Broadcast of the serial drama began in August 2001, and two new 15-minute episodes air each week. We examined associations between exposure to Makgabaneng and outcomes related to HIV testing, including stigmatizing attitudes, intention to be tested, talking with a partner about testing, and testing for HIV, among 555 sexually active respondents. The four measures of exposure to Makgabaneng were frequency of listening, duration of listening, talking about the program, and attentiveness to and identification with relevant characters. Data were collected approximately IS months after the drama began airing. We found positive associations between exposure to the program and intermediate Outcomes, including lower level of stigmatizing attitudes, stronger intention to have HIV testing, and talking to a partner about testing. Although associations were identified with all four measures of exposure, increased duration of listening was associated with more positive outcomes than the other measures. This finding Suggests that longer term exposure to entertainment-education programming may be important for behavior change. C1 [Pappas-DeLuca, Katina A.] Ctr Dis Control & Prevent, Div Reprod Hlth, Womens Hlth & Fertil Branch, CDC, Atlanta, GA 30333 USA. [Hastings, Phil] Far Harbor LLC, Austin, TX USA. [Mooki, Maungo] Nesswana, Gaborone, Botswana. [Koppenhaver, Todd] Axiom Resource Management, Falls Church, VA USA. [Koppenhaver, Todd; Roels, Thierry H.; Kilmarx, Peter H.] BOTUSA Project, Gaborone, Botswana. RP Pappas-DeLuca, KA (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Womens Hlth & Fertil Branch, CDC, 4770 Buford Hwy NE,Mailstop K-34, Atlanta, GA 30333 USA. EM kpdeluca@gmail.com NR 47 TC 14 Z9 14 U1 0 U2 7 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 0899-9546 J9 AIDS EDUC PREV JI Aids Educ. Prev. PD DEC PY 2008 VL 20 IS 6 BP 486 EP 503 DI 10.1521/aeap.2008.20.6.486 PG 18 WC Education & Educational Research; Public, Environmental & Occupational Health SC Education & Educational Research; Public, Environmental & Occupational Health GA 382CU UT WOS:000261583400002 PM 19072525 ER PT J AU Duong, YT Jia, H Lust, JA Garcia, AD Tiffany, AJ Heneine, W Switzer, WM AF Duong, Yen T. Jia, Hongwei Lust, John A. Garcia, Albert D. Tiffany, Amanda J. Heneine, Walid Switzer, William M. TI Short Communication Absence of Evidence of HTLV-3 and HTLV-4 in Patients with Large Granular Lymphocyte (LGL) Leukemia SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID LYMPHOPROLIFERATIVE DISEASE; LYMPHOTROPIC VIRUSES; SEROREACTIVITY AB Clonal disorders of large granular lymphocytes (LGL) result in leukemia due to the expansion of a discrete subset of either CD3(+) T cells or natural killer (NK) cells. It has been hypothesized that a viral antigen acts as the initial stimulus causing the expansion of these cells. The possible involvement of human T cell lymphotropic virus types 1 and 2 ( HTLV-1 and HTLV-2) in this disease has been studied but no conclusive evidence has linked either virus with LGL leukemia. In this study, we examined whether HTLV-3 or HTLV-4, two newly identified HTLV groups discovered in Central Africa in primate hunters, is involved in LGL leukemia. We developed two specific real-time PCR quantitative assays that are highly sensitive, capable of detecting 10 copies of HTLV-3 or HTLV-4 pol sequences in a background of 1 mu g of DNA from human peripheral blood lymphocytes (PBL). We tested PBL DNA samples from 40 LGL leukemia patients in the United States and found that all samples were negative for HTLV-3 or HTLV-4 infection. These results suggest that HTLV- 3 and HTLV- 4 are not the causative agent of LGL leukemia. C1 [Duong, Yen T.; Jia, Hongwei; Garcia, Albert D.; Tiffany, Amanda J.; Heneine, Walid; Switzer, William M.] Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA. [Lust, John A.] Mayo Clin Med, Rochester, MN 55905 USA. RP Switzer, WM (reprint author), Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, 1600 Clifton Rd,MS G-45, Atlanta, GA 30333 USA. EM bis3@cdc.gov NR 13 TC 12 Z9 12 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD DEC PY 2008 VL 24 IS 12 BP 1503 EP 1505 DI 10.1089/aid.2008.0128 PG 3 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 386UG UT WOS:000261907500004 PM 19102684 ER PT J AU Looker, AC Pfeiffer, CM Lacher, DA Schleicher, RL Picciano, MF Yetley, EA AF Looker, Anne C. Pfeiffer, Christine M. Lacher, David A. Schleicher, Rosemary L. Picciano, Mary Frances Yetley, Elizabeth A. TI Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004 SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article ID VITAMIN-D DEFICIENCY; UNITED-STATES; PREVALENCE; ADOLESCENTS; CHILDREN; INFANTS; OBESITY; FUTURE; CANCER; ADULTS AB Background: Changes in serum 25-hydroxyvitamin D [ 25(OH) D] concentrations in the US population have not been described. Objective: We used data from the National Health and Nutrition Examination Surveys (NHANES) to compare serum 25(OH) D concentrations in the US population in 2000-2004 with those in 1988-1994 and to identify contributing factors. Design: Serum 25(OH) D was measured with a radioimmunoassay kit in 20 289 participants in NHANES 2000-2004 and in 18 158 participants in NHANES III (1988-1994). Body mass index (BMI) was calculated from measured height and weight. Milk intake and sun protection were assessed by questionnaire. Assay differences were assessed by re-analyzing 150 stored serum specimens from NHANES III with the current assay. Results: Age-adjusted mean serum 25(OH) D concentrations were 5-20 nmol/L lower in NHANES 2000-2004 than in NHANES III. After adjustment for assay shifts, age-adjusted means in NHANES 2000-2004 remained significantly lower (by 5-9 nmol/L) in most males, but not in most females. In a study subsample, adjustment for the confounding effects of assay differences changed mean serum 25(OH) D concentrations by approximate to 10 nmol/L, and adjustment for changes in the factors likely related to real changes in vitamin D status (ie, BMI, milk intake, and sun protection) changed mean serum 25(OH) D concentrations by 1-1.6 nmol/L. Conclusions: Overall, mean serum 25(OH) D was lower in 2000-2004 than 1988-1994. Assay changes unrelated to changes in vitaminD status accounted for much of the difference in most population groups. In an adult subgroup, combined changes in BMI, milk intake, and sun protection appeared to contribute to a real decline in vitamin D status. Am J Clin Nutr 2008; 88: 1519-27. C1 [Looker, Anne C.; Lacher, David A.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Pfeiffer, Christine M.; Schleicher, Rosemary L.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. [Picciano, Mary Frances; Yetley, Elizabeth A.] NIH, Off Dietary Supplements, Bethesda, MD 20892 USA. RP Looker, AC (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Room 4310,3311 Belcrest Rd, Hyattsville, MD 20782 USA. EM acl1@cdc.gov FU NIH HHS [Y01 OD4322-01] NR 22 TC 352 Z9 367 U1 2 U2 13 PU AMER SOC CLINICAL NUTRITION PI BETHESDA PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998 USA SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD DEC 1 PY 2008 VL 88 IS 6 BP 1519 EP 1527 DI 10.3945/ajcn.2008.26182 PG 9 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 380EO UT WOS:000261449200010 PM 19064511 ER PT J AU Cusick, SE Mei, ZG Freedman, DS Looker, AC Ogden, CL Gunter, E Cogswell, ME AF Cusick, Sarah E. Mei, Zuguo Freedman, David S. Looker, Anne C. Ogden, Cynthia L. Gunter, Elaine Cogswell, Mary E. TI Unexplained decline in the prevalence of anemia among US children and women between 1988-1994 and 1999-2002 SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article ID IRON-DEFICIENCY ANEMIA; TOTAL HOMOCYSTEINE CONCENTRATIONS; NUTRITION EXAMINATION SURVEYS; NEURAL-TUBE DEFECTS; UNITED-STATES; NATIONAL-HEALTH; CAUSAL RELATIONSHIP; CHILDHOOD ANEMIA; FOLIC-ACID; FOLATE AB Background: The current anemia burden among US preschool children and women of childbearing age has not been documented. Objective: We used data from National Health and Nutrition Examination Surveys 1988-1994 and 1999-2002 to examine recent anemia changes. Design: We calculated the prevalence of anemia (hemoglobin < 11.0 g/dL at < 24 mo, < 11.1 g/dL at 24-59 mo, and < 12.0 g/dL for women), iron deficiency anemia (anemia plus abnormal value >= 2: serum ferritin, transferrin saturation, and erythrocyte protoporphyrin), and high blood lead (>= 10 mu g/dL) with anemia among children 12-59 mo and women 20-49 y in both surveys. Among women, we also calculated the prevalence of folate deficiency (erythrocyte folate < 317.2 nmol/L) with anemia and high C-reactive protein (> 10 mg/L) with anemia. Multiple logistic regression was used to compare anemia prevalence between surveys, with control for race and age. Results: Anemia declined significantly in children (from 8.0% to 3.6%; OR: 0.4; 95% CI: 0.3, 0.7) and women (10.8% to 6.9%; OR: 0.6; CI: 0.4, 0.7), but the prevalence of iron deficiency anemia did not change significantly in children (1.5% compared with 1.2%; OR: 0.7; 95% CI: 0.4, 1.5) or women (4.9% compared with 4.1%; OR: 0.8; 95% CI: 0.6, 1.1). Folate deficiency with anemia declined significantly in women (from 4.1% to 0.5%; OR: 0.1; 95% CI: 0.1, 0.2), but logistic regression models and standardization indicated that none of the known possible anemia causes could account for the decline in total anemia in children or women. Conclusions: The prevalence of anemia declined significantly among US women and children between 1988-1994 and 1999-2002, but this decline was not associated with changes in iron or folate deficiency, inflammation, or high blood lead. Am J Clin Nutr 2008; 88: 1611-7. C1 [Cusick, Sarah E.; Mei, Zuguo; Freedman, David S.; Cogswell, Mary E.] US Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Nutr Phys Activ & Obes, Atlanta, GA USA. [Looker, Anne C.; Ogden, Cynthia L.] Natl Ctr Hlth Stat, Atlanta, GA USA. [Gunter, Elaine] Natl Ctr Environm Hlth, Atlanta, GA USA. RP Cusick, SE (reprint author), 4770 Buford Highway,MS K-25, Atlanta, GA 30341 USA. EM scusick@cdc.gov NR 55 TC 35 Z9 35 U1 0 U2 0 PU AMER SOC CLINICAL NUTRITION PI BETHESDA PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998 USA SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD DEC 1 PY 2008 VL 88 IS 6 BP 1611 EP 1617 DI 10.3945/ajcn.2008.25926 PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 380EO UT WOS:000261449200021 PM 19064522 ER PT J AU La'ulu, SL Rawlins, ML Pfeiffer, CM Zhang, MD Roberts, WL AF La'ulu, Sonia L. Rawlins, Mindy L. Pfeiffer, Christine M. Zhang, Mindy Roberts, William L. TI Performance Characteristics of Six Homocysteine Assays SO AMERICAN JOURNAL OF CLINICAL PATHOLOGY LA English DT Article DE Homocysteine; Method comparison; Imprecision ID PLASMA TOTAL HOMOCYSTEINE; FLUORESCENCE POLARIZATION IMMUNOASSAY; MULTICENTER ANALYTICAL EVALUATION; LIQUID-CHROMATOGRAPHY METHOD; ENZYME-IMMUNOASSAY; DPC IMMULITE-2000; SERUM; QUANTIFICATION; VALIDATION; CHEMISTRY AB Elevated concentrations of homocysteine (Hcy) are associated with a range of disorders. Linearity, imprecision, interference, method comparison, and accuracy were evaluated on the ADVIA Centaur (Siemens Healthcare Diagnostics, Deerfield, IL), ARCHITECT i2000(SR) (Abbott Diagnostics, Abbott Park, IL), AxSYM (Abbott Diagnostics), and IMMULITE 2000 (Siemens Healthcare Diagnostics) methods and analyzers and the Catch (Equal Diagnostics, Exton, PA) and Diazyme (Diazyme Laboratories, San Diego, CA) methods, both on the Modular P analyzer (Roche Diagnostics, Indianapolis, IN). All methods were linear with maximum deviations from target recoveries of less than 10%. Total coefficients of variation ranged from 1.7% to 9.4%. The effects of hemolysis, icterus, and lipemia were assessed. Method comparisons were performed using high-performance liquid chromatography as the comparison method. Correlation coefficients were 0.95 to 0.99. Bland-Altman plots demonstrated percentage bias of -29.3% (IMMULITE) to 7.2% (Centaur). Accuracy using the National Institute of Standards and Technology Standard Reference Material 1955 showed varying results with only 1 method within the certified range for all 3 levels. All methods demonstrated acceptable performance except the IMMULITE, which is less precise and accurate. Standardization of most methods seems acceptable, although continuing efforts are warranted. C1 [La'ulu, Sonia L.; Rawlins, Mindy L.] ARUP Inst Clin & Expt Pathol, Salt Lake City, UT USA. [Pfeiffer, Christine M.; Zhang, Mindy] Ctr Dis Control & Prevent, Atlanta, GA USA. [Roberts, William L.] Univ Utah, Hlth Sci Ctr, Dept Pathol, Salt Lake City, UT 84132 USA. RP Roberts, WL (reprint author), ARUP Labs, 500 Chipeta Way, Salt Lake City, UT 84108 USA. FU Abbott Diagnostics; ARUP Institute for Clinical and Experimental Pathology FX Supported by Abbott Diagnostics and the ARUP Institute for Clinical and Experimental Pathology. NR 36 TC 9 Z9 10 U1 0 U2 4 PU AMER SOC CLINICAL PATHOLOGY PI CHICAGO PA 2100 W HARRISON ST, CHICAGO, IL 60612 USA SN 0002-9173 J9 AM J CLIN PATHOL JI Am. J. Clin. Pathol. PD DEC PY 2008 VL 130 IS 6 BP 969 EP 975 DI 10.1309/AJCP64BJIPNPSQDJ PG 7 WC Pathology SC Pathology GA 373UV UT WOS:000260999900019 PM 19019776 ER PT J AU Slickers, JE Olshan, AF Siega-Riz, AM Honein, MA Aylsworth, AS AF Slickers, Jennifer E. Olshan, Andrew F. Siega-Riz, Anna Maria Honein, Margaret A. Aylsworth, Arthur S. CA Natl Birth Defects Prevention Stud TI Maternal Body Mass Index and Lifestyle Exposures and the Risk of Bilateral Renal Agenesis or Hypoplasia SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article ID BONE MORPHOGENETIC PROTEIN-4; BIRTH-DEFECTS PREVENTION; CONGENITAL-MALFORMATIONS; DIABETES-MELLITUS; COCAINE ABUSE; ANOMALIES; PREGNANCY; ALCOHOL; OBESITY; CONSUMPTION AB Increased maternal body mass index, maternal smoking, and alcohol exposure during pregnancy have been inconsistently reported as potential risk factors for renal birth defects. The low incidence of the most severe renal anomaly, bilateral renal agenesis or hypoplasia (RA/H), has limited the ability to study this fatal defect. Using data from the National Birth Defects Prevention Study, a multicenter case-control study, the authors explored potential relations between RA/H and maternal body mass index, smoking, alcohol, and caffeine exposures. Data available for 75 infants with RA/H born between 1997 and 2003 and for randomly selected control infants without known birth defects (n = 868) were assessed by a model adjusted for folic acid use, all four exposures of interest, and study center. Bilateral RA/H was associated with a body mass index of greater than 30 kg/m(2) prior to pregnancy (adjusted odds ratio (aOR) = 1.92, 95% confidence interval (CI): 1.00, 3.67), smoking during the periconceptional period (aOR = 2.09, 95% CI: 1.08, 4.03), and binge drinking during the second month of pregnancy (aOR = 3.64, 95% CI: 1.19, 11.1). These results support the need for further exploration into the potential mechanisms by which such exposures could interfere with early fetal kidney formation resulting in RA/H. C1 [Slickers, Jennifer E.; Olshan, Andrew F.; Siega-Riz, Anna Maria] Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27599 USA. [Slickers, Jennifer E.] Univ N Carolina, UNC Kidney Ctr, Chapel Hill, NC 27599 USA. [Siega-Riz, Anna Maria] Univ N Carolina, Sch Publ Hlth, Dept Nutr, Chapel Hill, NC 27599 USA. [Honein, Margaret A.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Aylsworth, Arthur S.] Univ N Carolina, Sch Med, Dept Pediat & Genet, Chapel Hill, NC 27599 USA. RP Olshan, AF (reprint author), Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Campus Box 7435, Chapel Hill, NC 27599 USA. EM andy_olshan@unc.edu RI Publications, NBDPS/B-7692-2013 NR 46 TC 24 Z9 24 U1 1 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD DEC 1 PY 2008 VL 168 IS 11 BP 1259 EP 1267 DI 10.1093/aje/kwn248 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 377VK UT WOS:000261279600005 PM 18835865 ER PT J AU Durkin, MS Maenner, MJ Newschaffer, CJ Lee, LC Cunniff, CM Daniels, JL Kirby, RS Leavitt, L Miller, L Zahorodny, W Schieve, LA AF Durkin, Maureen S. Maenner, Matthew J. Newschaffer, Craig J. Lee, Li-Ching Cunniff, Christopher M. Daniels, Julie L. Kirby, Russell S. Leavitt, Lewis Miller, Lisa Zahorodny, Walter Schieve, Laura A. TI Advanced Parental Age and the Risk of Autism Spectrum Disorder SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article ID ASSISTED REPRODUCTIVE TECHNOLOGY; PATERNAL AGE; INFANTILE-AUTISM; PERINATAL FACTORS; BIRTH; EPIDEMIOLOGY; SURVEILLANCE; POPULATION; PREVALENCE; CHILDREN AB This study evaluated independent effects of maternal and paternal age on risk of autism spectrum disorder. A case-cohort design was implemented using data from 10 US study sites participating in the Centers for Disease Control and Prevention's Autism and Developmental Disabilities Monitoring Network. The 1994 birth cohort included 253,347 study-site births with complete parental age information. Cases included 1,251 children aged 8 years with complete parental age information from the same birth cohort and identified as having an autism spectrum disorder based on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria. After adjustment for the other parent's age, birth order, maternal education, and other covariates, both maternal and paternal age were independently associated with autism (adjusted odds ratio for maternal age >= 35 vs. 25-29 years = 1.3, 95% confidence interval: 1.1, 1.6; adjusted odds ratio for paternal age >= 40 years vs. 25-29 years = 1.4, 95% confidence interval: 1.1, 1.8). Firstborn offspring of 2 older parents were 3 times more likely to develop autism than were third- or later-born offspring of mothers aged 20-34 years and fathers aged < 40 years (odds ratio = 3.1, 95% confidence interval: 2.0, 4.7). The increase in autism risk with both maternal and paternal age has potential implications for public health planning and investigations of autism etiology. C1 [Durkin, Maureen S.] Univ Wisconsin, Sch Med & Publ Hlth, Waisman Ctr, Dept Populat Hlth Sci, Madison, WI 53726 USA. [Durkin, Maureen S.; Leavitt, Lewis] Univ Wisconsin, Sch Med & Publ Hlth, Dept Pediat, Madison, WI 53726 USA. [Newschaffer, Craig J.] Drexel Univ, Dept Epidemiol, Philadelphia, PA 19104 USA. [Lee, Li-Ching] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. [Cunniff, Christopher M.] Univ Arizona, Coll Med, Dept Pediat, Tucson, AZ USA. [Daniels, Julie L.] Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA. [Kirby, Russell S.] Univ Alabama, Sch Publ Hlth, Dept Maternal & Child Hlth, Birmingham, AL 35294 USA. [Miller, Lisa] Dept Publ Hlth & Environm, Denver, CO USA. [Zahorodny, Walter] Univ Med & Dent New Jersey, Dept Pediat, New Jersey Med Sch, Trenton, NJ USA. [Schieve, Laura A.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. RP Durkin, MS (reprint author), Univ Wisconsin, Sch Med & Publ Hlth, Waisman Ctr, Dept Populat Hlth Sci, 789 WARF,610 Walnut St, Madison, WI 53726 USA. EM mdurkin@wisc.edu RI Durkin, Maureen/B-7834-2015 FU Centers for Disease Control and Prevention, Cooperative [UR3/CCU523235, UR3/DD000078]; University of Wisconsin FX This work was funded by the Centers for Disease Control and Prevention, Cooperative Agreements UR3/CCU523235 and UR3/DD000078. Additional funding for graduate student support for data analysis was provided by the University of Wisconsin.; The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 31 TC 166 Z9 172 U1 7 U2 33 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD DEC 1 PY 2008 VL 168 IS 11 BP 1268 EP 1276 DI 10.1093/aje/kwn250 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 377VK UT WOS:000261279600006 PM 18945690 ER PT J AU Hanssen, CE Lawrenz, F Dunet, DO AF Hanssen, Carl E. Lawrenz, Frances Dunet, Diane O. TI Concurrent Meta-Evaluation A Critique SO AMERICAN JOURNAL OF EVALUATION LA English DT Article DE evaluation methodology; meta-evaluation; site visits; evaluation standards; public health AB Meta-evaluations reported in the literature, although rare, often have focused on retrospective assessment of completed evaluations. Conducting a meta-evaluation concurrently with the evaluation modifies this approach. This method provides the opportunity for the meta-evaluators to advise the evaluators and provides the basis for a summative judgment about the quality of the evaluation. The authors conducted a concurrent meta-evaluation of a new evaluation technique being developed by a federal governmental agency; the new evaluation technique was expected to be highly visible and widely applied. The differences between concurrent meta-evaluation and other meta-evaluations were continuous involvement, attendance at data collection events, and external verification of the evaluation data. The authors' experience conducting the concurrent meta-evaluation is described and challenges are discussed in this critique. The authors conclude that concurrent meta-evaluation holds promise for improving the practice of evaluation and of meta-evaluation. C1 [Hanssen, Carl E.] Hanssen Consulting LLC, Grand Rapids, MI 49506 USA. [Lawrenz, Frances] Univ Minnesota, Minneapolis, MN 55455 USA. [Dunet, Diane O.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Hanssen, CE (reprint author), Hanssen Consulting LLC, 1324 Lake Dr SE,Suite 6, Grand Rapids, MI 49506 USA. EM carlh@hanssenconsulting.com NR 29 TC 9 Z9 9 U1 0 U2 4 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1098-2140 J9 AM J EVAL JI Am. J. Eval. PD DEC PY 2008 VL 29 IS 4 BP 572 EP 582 DI 10.1177/1098214008320462 PG 11 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA 373KX UT WOS:000260971600020 ER PT J AU Chatters, LM Bullard, KM Taylor, RJ Woodward, AT Neighbors, HW Jackson, JS AF Chatters, Linda M. Bullard, Kai McKeever Taylor, Robert Joseph Woodward, Amanda Toler Neighbors, Harold W. Jackson, James S. TI Religious Participation and DSM-IV Disorders Among Older African Americans: Findings From the National Survey of American Life SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY LA English DT Article DE Church attendance; depression; mood disorder ID WORLD-HEALTH-ORGANIZATION; MENTAL-HEALTH; PHYSICAL HEALTH; DEPRESSIVE SYMPTOMS; BLACK ADULTS; PREVALENCE; PRAYER; INVOLVEMENT; ATTENDANCE; RACE AB Objectives: This study examined the religious correlates of psychiatric disorders. Design: The analysis is based on the National Survey of American Life (NSAL). The African American sample of the NSAL is a national representative sample of households with at least one African American adult 18 years or over. This study uses the older African American subsample (N = 837). Methods: Religious correlates of selected measures of lifetime Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) psychiatric disorders (i.e., panic disorder, agoraphobia, social phobia, generalized anxiety disorder, obsessive compulsive disorder, posttraumatic stress, major depressive disorder, dysthymia, bipolar I & II disorders, alcohol abuse/dependence, and drug abuse/dependence) were examined. Participants: Data from 837 African Americans aged 55 years or older are used in this analysis. Measurement: The DSM-IV World Mental Health Composite International Diagnostic Interview was used to assess mental disorders. Measures of functional status (i.e., mobility and self-care) were assessed using the World Health Organization Disability Assessment Schedule-Second Version. Measures of organizational, nonorganizational and subjective religious involvement, number of doctor diagnosed physical health conditions, and demographic factors were assessed. Results: Multivariate analysis found that religious service attendance was significantly and inversely associated with the odds of having a lifetimemood disorder. Conclusions: This is the first study to investigate the relationship between religious participation and serious mental disorders among a national sample of older African Americans. The inverse relationship between religious service attendance and mood disorders is discussed. Implications for mental health treatment underscore the importance of assessing religious orientations to render more culturally sensitive care. (Am J Geriatr Psychiatry 2008; 16: 957-965) C1 [Chatters, Linda M.; Taylor, Robert Joseph] Univ Michigan, Sch Social Work, Ann Arbor, MI 48109 USA. [Chatters, Linda M.; Taylor, Robert Joseph; Jackson, James S.] Univ Michigan, Inst Social Res, Ann Arbor, MI 48109 USA. [Chatters, Linda M.; Neighbors, Harold W.] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA. [Chatters, Linda M.; Taylor, Robert Joseph; Neighbors, Harold W.; Jackson, James S.] Univ Michigan, Program Res Black Amer, Ann Arbor, MI 48109 USA. [Bullard, Kai McKeever] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA USA. [Woodward, Amanda Toler] Michigan State Univ, Sch Social Work, E Lansing, MI 48824 USA. RP Chatters, LM (reprint author), Univ Michigan, Sch Social Work, 1080 S Univ Ave,Room 3852, Ann Arbor, MI 48109 USA. EM chatters@umich.edu FU National Institute of Mental Health (NIMH) [U01MH57716]; University of Michigan; National Institute on Aging [R01 AG18782, P30AG1528] FX This work was supported by the National Institute of Mental Health (NIMH) for data collection (U01MH57716) with supplemental support from the Office of Behavioral and Social Science Research at the National Institutes of Health (NIH) and the University of Michigan. The preparation of this manuscript was supported by grants from the National Institute on Aging (R01 AG18782) (to LMC, RJT) and (P30AG1528) (to RJT, JSJ). NR 35 TC 37 Z9 37 U1 2 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1064-7481 J9 AM J GERIAT PSYCHIAT JI Am. J. Geriatr. Psychiatr. PD DEC PY 2008 VL 16 IS 12 BP 957 EP 965 DI 10.1097/JGP.0b013e3181898081 PG 9 WC Geriatrics & Gerontology; Gerontology; Psychiatry SC Geriatrics & Gerontology; Psychiatry GA 376PJ UT WOS:000261195200003 PM 19038894 ER PT J AU Calvert, GM Karnik, J Mehler, L Beckman, J Morrissey, B Sievert, J Barrett, R Lackovic, M Mabee, L Schwartz, A Mitchell, Y Moraga-McHaley, S AF Calvert, Geoffrey M. Karnik, Jennifer Mehler, Louise Beckman, John Morrissey, Barbara Sievert, Jennifer Barrett, Rosanna Lackovic, Michelle Mabee, Laura Schwartz, Abby Mitchell, Yvette Moraga-McHaley, Stephanie TI Acute Pesticide Poisoning Among Agricultural Workers in the United States, 1998-2005 SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE LA English DT Article DE pesticides; surveillance; poisoning; agriculture; farmworkers ID HEALTH; FARMWORKERS; ILLNESS; MIGRANT; US AB Background Approximotely 75% of pesticide usage in the United States occurs in agriculture. As such, agricultural workers are at greater risk of pesticide exposure than non-agricultural workers. However the magnitude, characteristics and trend of acute pesticide poisoning among agricultural workers are unknown. Methods We identified acute pesticide poisoning cases in agricultural workers between the ages of 15 and 64 years that occurred from 1998 to 2005. The California Department of Pesticide Regulation and the SENSOR-pesticides program provided the cases. Acute occupational pesticide poisoning incidence rates (IR)for those employed in agriculture were calculated, as were incidence rate ratios (IRR) among agricultural workers relative to non-agricultural workers. Results Of the 3,271 cases included in the analysis, 2,334 (71%) were employed as farmworkers. The remaining cases were employed as processing/packing plant workers (12%), farmers (3%), and other miscellaneous agricultural workers (19%). The majority of cases had low severity illness (N = 2,848, 87%), while 402 (12%) were of medium severity and 20 (0.6%) were of high severity. One case was fatal. Rates of illness among various agricultural worker categories were highly variable but all, except farmers, Showed risk for agricultural workers greater than risk for non-agricultural workers by an order of magnitude or more. Also, the rate among female agricultural workers was almost twofold higher compared to males. Conclusion The findings from this study suggest that acute pesticide poisoning in the agricultural industry continues to be an important problem. These findings reinforce the need for heightened efforts to better protect farmworkers from pesticide exposure. Am. J. Ind. Med. 51:883-898, 2008. Published 2008 Wiley-Liss, Inc.dagger C1 [Calvert, Geoffrey M.; Karnik, Jennifer] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Mehler, Louise] Calif Environm Protect Agcy, Dept Pesticide Regulat, Sacramento, CA USA. [Beckman, John] Inst Publ Hlth, Oakland, CA USA. [Morrissey, Barbara] Washington State Dept Hlth, Off Environm Assessments, Olympia, WA USA. [Sievert, Jennifer] Texas Dept State Hlth Serv, Environm & Injury Epidemiol & Toxicol Branch, Austin, TX USA. [Barrett, Rosanna] Florida Dept Hlth, Tallahassee, FL USA. [Lackovic, Michelle] Louisiana Dept Hlth & Hosp, New Orleans, LA USA. [Mabee, Laura] Oregon Dept Human Serv, Off Environm Publ Hlth, Portland, OR USA. [Schwartz, Abby] Michigan Dept Community Hlth, Div Environm Hlth, Lansing, MI USA. [Mitchell, Yvette] New York State Dept Hlth, Bur Occupat Hlth, Troy, NY USA. [Moraga-McHaley, Stephanie] Univ New Mexico, New Mexico Occupat Hlth Registry, Albuquerque, NM 87131 USA. RP Calvert, GM (reprint author), NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Ctr Dis Control & Prevent, 4676 Columbia Pkwy,R-17, Cincinnati, OH 45226 USA. EM jac6@cdc.gov FU NIOSH; EPA FX Funding to support this study was provided by NIOSH, EPA, and the state agencies that contributed data. NR 39 TC 58 Z9 62 U1 4 U2 18 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0271-3586 J9 AM J IND MED JI Am. J. Ind. Med. PD DEC PY 2008 VL 51 IS 12 BP 883 EP 898 DI 10.1002/ajim.20623 PG 16 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 376QP UT WOS:000261198400001 PM 18666136 ER PT J AU Lehman, EJ Hein, MJ Estill, CF AF Lehman, Everett J. Hein, Misty J. Estill, Cheryl F. TI Proportionate Mortality Study of the United Association of journeymen and Apprentices of the Plumbing and Pipe Fitting Industry SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE LA English DT Article DE construction; plumber; pipe-fitter; sprinkler-fitter; asbestos ID SAFETY-AND-HEALTH; STATES; WORKER; COHORT; OCCUPATION; PATTERNS; CANCER; RATIO; CONSTRUCTION; PIPEFITTERS AB Background This study examined causes of deaths among unionized plumbers, pipefitters and allied trades. Methods Deaths of union members from. the years 1971, 1979, 1987, and 1995 were selected as a representative sample from a computer file provided by the union. These years provided 15,411 deaths for proportionate mortality ratio (PAIR) analysis. Results PMRs for lung cancer and asbestosis were significantly elevated compared to U.S. white males. PMRs for chronic disease of the endocardium and cardiomyopathy were also elevated. Elevations were not observed in other a priori causes: laryngeal cancer lymphatic cancer and neurological disorders. PMRs.for transportation accidents for pipe/steam-fitters were elevated in 1971 and 1979, but not in 1987 or 1995. Conclusion Despite the limitations of a PMR analysis, study results indicate mortality related to asbestos exposure is, and will continue to be, an area of concern for members of the union. Am. J. Ind. Med. 51:950-963, 2008. Published 2008 Wiley-Liss, Inc.(dagger) C1 [Lehman, Everett J.; Hein, Misty J.; Estill, Cheryl F.] NIOSH, Cincinnati, OH 45226 USA. RP Lehman, EJ (reprint author), 4676 Columbia Pkwy,M-S-R13, Cincinnati, OH 45226 USA. EM elehman@cdc.gov FU National Institute for Occupational Safety and Health; U.S. Government FX The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institute for Occupational Safety and Health. All funds supporting this project were provided by the U.S. Government. NR 48 TC 6 Z9 6 U1 2 U2 2 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0271-3586 J9 AM J IND MED JI Am. J. Ind. Med. PD DEC PY 2008 VL 51 IS 12 BP 950 EP 963 DI 10.1002/ajim.20640 PG 14 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 376QP UT WOS:000261198400007 PM 18942099 ER PT J AU Patel, PR Srinivasan, A Perz, JF AF Patel, Priti R. Srinivasan, Arjun Perz, Joseph F. TI Developing a broader approach to management of infection control breaches in health care settings SO AMERICAN JOURNAL OF INFECTION CONTROL LA English DT Editorial Material ID HEPATITIS-C VIRUS; DISEASE TRANSMISSION; RISK; DISINFECTION; ENDOSCOPY AB Our experiences with health departments and health care facilities suggest that questions Surrounding instrument reprocessing errors and other infection control breaches are becoming increasingly common. We describe an approach to management of these incidents that focuses on risk of bloodborne pathogen transmission and the role of public health and other stakeholders to inform patient notification and testing decisions, (Am J Infect Control 2008:36:685-90.) C1 [Patel, Priti R.; Srinivasan, Arjun; Perz, Joseph F.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. [Perz, Joseph F.] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30333 USA. RP Patel, PR (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, 1600 Clifton Rd,MS A-31, Atlanta, GA 30333 USA. EM ppatel@cdc.gov NR 17 TC 12 Z9 12 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-6553 J9 AM J INFECT CONTROL JI Am. J. Infect. Control PD DEC PY 2008 VL 36 IS 10 BP 685 EP 690 DI 10.1016/j.ajic.2008.04.255 PG 6 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 385FY UT WOS:000261801300002 PM 19084163 ER PT J AU Knapp, MB McIntyre, R Sinkowitz-Cochran, RL Pearson, ML AF Knapp, Megan Bush McIntyre, Rosemarie Sinkowitz-Cochran, Ronda L. Pearson, Michele L. TI Assessment of health care personnel needs for training in infection control: One size does not fit SO AMERICAN JOURNAL OF INFECTION CONTROL LA English DT Article ID RESISTANCE; PERCEPTIONS; PHYSICIANS AB To guide development of infection control education, we conducted a pilot needs assessment to determine Current infection control knowledge, identify potential gaps between knowledge and practice, and identify perceived training needs among a varied group of health care personnel. A total of 23 health care personnel from various disciplines and health care settings completed the self-administered Web-based survey Differences in knowledge and self-identified training needs were found among disciplines. Future research may well focus on further exploring specific needs of different disciplines. These results will be used to inform topics to cover in infection control curricula for clinicians, public health professionals, and allied health personnel. (Am J Infect Control 2008:36:757-60.) C1 [Knapp, Megan Bush; McIntyre, Rosemarie; Sinkowitz-Cochran, Ronda L.; Pearson, Michele L.] Ctr Dis Control & Prevent, Prevent & Evaluat Branch, Div Healthcare Qual Promot, Natl Ctr Infect Dis,US Dept HHS, Atlanta, GA 30333 USA. RP Sinkowitz-Cochran, RL (reprint author), Ctr Dis Control & Prevent, Prevent & Evaluat Branch, Div Healthcare Qual Promot, Natl Ctr Infect Dis,US Dept HHS, 1600 Clifton Rd,MS A-31, Atlanta, GA 30333 USA. EM rls7@cdc.gov NR 10 TC 5 Z9 5 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-6553 J9 AM J INFECT CONTROL JI Am. J. Infect. Control PD DEC PY 2008 VL 36 IS 10 BP 757 EP 760 DI 10.1016/j.ajic.2008.01.005 PG 4 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 385FY UT WOS:000261801300014 PM 18834737 ER PT J AU Rasmussen, SA Whitehead, N Cottier, SA Frias, JL AF Rasmussen, Sonja A. Whitehead, Nedra Cottier, Sarah A. Frias, Jaime L. TI Setting a Public Health Research Agenda for Down Syndrome: Summary of a Meeting Sponsored by the Centers for Disease Control and Prevention and the National Down Syndrome Society SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A LA English DT Editorial Material ID FRAGILE-X-SYNDROME; TYPICALLY DEVELOPING-CHILDREN; SHORT-TERM-MEMORY; PRADER-WILLI-SYNDROME; ATHEROMA-FREE MODEL; MENTAL-RETARDATION; YOUNG-CHILDREN; DEVELOPMENTAL-DISABILITIES; BEHAVIOR PROBLEMS; INTELLECTUAL DISABILITY C1 [Rasmussen, Sonja A.; Cottier, Sarah A.; Frias, Jaime L.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Whitehead, Nedra] RTI Int, Atlanta, GA USA. [Cottier, Sarah A.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Frias, Jaime L.] McKing Consulting Corp, Atlanta, GA USA. RP Rasmussen, SA (reprint author), 1600 Clifton Rd,MS E-86, Atlanta, GA 30333 USA. EM skr9@edc.gov NR 126 TC 29 Z9 29 U1 1 U2 2 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1552-4825 J9 AM J MED GENET A JI Am. J. Med. Genet. A PD DEC 1 PY 2008 VL 146A IS 23 BP 2998 EP 3010 DI 10.1002/ajmg.a.32581 PG 13 WC Genetics & Heredity SC Genetics & Heredity GA 382WM UT WOS:000261636100003 PM 19006076 ER PT J AU Atrash, H Jack, BW Johnson, K Coonrod, DV Moos, MK Stubblefield, PG Cefalo, R Damus, K Reddy, UM AF Atrash, Hani Jack, Brian W. Johnson, Kay Coonrod, Dean V. Moos, Merry-K Stubblefield, Phillip G. Cefalo, Robert Damus, Karla Reddy, Uma M. TI Where is the "W"oman in MCH? SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE maternal and child health; preconception; woman ID PRECONCEPTIONAL HEALTH-PROMOTION; UNITED-STATES; EISENMENGER-SYNDROME; FOLIC-ACID; CARE; PREGNANCY; WOMEN; PROVIDER; MANAGEMENT; WELLNESS AB Scientific evidence indicates that improving a woman's health before pregnancy will improve pregnancy outcomes. However, for many years, our efforts have focused primarily on prenatal care and on caring for infants after birth. The concept of preconception care has been identified repeatedly as a priority for improving maternal and infant health. Preconception care is not something new that is being added to the already overburdened healthcare provider, but it is a part of routine primary care for women of reproductive age. Many opportunities exist for preconception intervention, and much of preconception care involves merely the provider reframing his or her thinking, counseling, and decisions in light of the reproductive plans and sexual and contraceptive practices of the patient. With existing scientific evidence that improving the health of "W"omen will improve the health of mothers and children, we must focus on improving the health of "W"omen before pregnancy and put the "W" in Maternal and Child Health. C1 [Atrash, Hani] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Jack, Brian W.] Boston Univ, Sch Med, Dept Family Med, Boston, MA 02118 USA. [Stubblefield, Phillip G.] Boston Univ, Sch Med, Dept Obstet & Gynecol, Boston, MA 02118 USA. [Johnson, Kay] Dartmouth Med Sch, Dept Pediat, Lebanon, NH USA. [Coonrod, Dean V.] Maricopa Cty Gen Hosp, Dept Obstet & Gynecol, Phoenix, AZ USA. [Moos, Merry-K; Cefalo, Robert] Univ N Carolina, Sch Med, Dept Obstet & Gynecol, Chapel Hill, NC USA. [Damus, Karla] Albert Einstein Coll Med & Natl March Dimes, Dept Obstet & Gynecol & Womens Hlth, White Plains, NY USA. [Reddy, Uma M.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USA. RP Atrash, H (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. OI Jack, Brian/0000-0002-6497-2437 FU CMS [# 1HOCMS030207 101] FX Hani Atrash, MD, MPH; Brian W. Jack, MD; Kay Johnson, MPH, EdM; Merry- K Moos, BSN, FNP, MPH; Phillip G. Stubblefield, MD; Robert Cefalo, MD, PhD; Karla Damus, MSPH, PhD, RN; and Uma M. Reddy, MD, MPH have no conflict of interest including grants, honoraria, advisory board membership, or share holdings. Dean V. Coonrod, MD, MPH is a Grant Recipient from the March of Dimes Arizona Chapter to develop an internatal Care Clinic and has funding from CMS (# 1HOCMS030207 101) working on compliance with the 6 week postpartum visit as a strategy to improve preconception care. NR 64 TC 25 Z9 27 U1 2 U2 8 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD DEC PY 2008 VL 199 IS 6 SU 2 BP S259 EP S265 DI 10.1016/j.ajog.2008.08.059 PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 382BP UT WOS:000261580200002 PM 19081420 ER PT J AU Coonrod, DV Jack, BW Stubblefield, PG Hollier, LM Boggess, KA Cefalo, R Cox, SN Dunlop, AL Hunter, KD Prasad, MR Lu, MC Conry, JA Gibbs, RS Hogan, VK AF Coonrod, Dean V. Jack, Brian W. Stubblefield, Phillip G. Hollier, Lisa M. Boggess, Kim A. Cefalo, Robert Cox, Shanna N. Dunlop, Anne L. Hunter, Kam D. Prasad, Mona R. Lu, Michael C. Conry, Jeanne A. Gibbs, Ronald S. Hogan, Vijaya K. TI The clinical content of preconception care: infectious diseases in preconception care SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Review DE infectious disease; preconception; screening ID RANDOMIZED CONTROLLED-TRIAL; HEPATITIS-C VIRUS; PARVOVIRUS B19 INFECTION; LOW-BIRTH-WEIGHT; ASYMPTOMATIC BACTERIAL VAGINOSIS; LISTERIA-MONOCYTOGENES INFECTION; PREVENT PRETERM DELIVERY; HERPES-SIMPLEX-VIRUS; PREGNANT-WOMEN; GENITAL-TRACT AB A number of infectious diseases should be considered for inclusion as part of clinical preconception care. Those infections strongly recommended for health promotion messages and risk assessment or for the initiation of interventions include Chlamydia infection, syphilis, and HIV. For selected populations, the inclusion of interventions for tuberculosis, gonorrheal infection, and herpes simplex virus are recommended. No clear evidence exists for the specific inclusion in preconception care of hepatitis C, toxoplasmosis, cytomegalovirus, listeriosis, malaria, periodontal disease, and bacterial vaginosis ( in those with a previous preterm birth). Some infections that have important consequences during pregnancy, such as bacterial vaginosis ( in those with no history of preterm birth), asymptomatic bacteriuria, parvovirus, and group B streptococcus infection, most likely would not be improved through intervention in the preconception time frame. C1 [Coonrod, Dean V.] Maricopa Cty Gen Hosp, Dept Obstet & Gynecol, OBGYN Dept, Phoenix, AZ 85008 USA. [Hunter, Kam D.] Maricopa Cty Gen Hosp, Dept Family & Community Med, Phoenix, AZ 85008 USA. [Jack, Brian W.] Boston Univ, Med Ctr, Dept Family Med, Boston, MA USA. [Stubblefield, Phillip G.] Boston Univ, Med Ctr, Dept Obstet & Gynecol, Boston, MA USA. [Hollier, Lisa M.] Univ Texas Houston, Sch Med, Dept Obstet Gynecol & Reprod Sci, Houston, TX USA. [Boggess, Kim A.; Cefalo, Robert] Univ N Carolina, Sch Publ Hlth, Dept Obstet & Gynecol, Chapel Hill, NC USA. [Hogan, Vijaya K.] Univ N Carolina, Sch Publ Hlth, Dept Maternal & Child Hlth, Chapel Hill, NC USA. [Cox, Shanna N.] NCCDPHP, Ctr Dis Control, Div Reprod Hlth, Atlanta, GA USA. [Dunlop, Anne L.] Emory Univ, Sch Med, Dept Family & Prevent Med, Atlanta, GA USA. [Prasad, Mona R.] Ohio State Univ, Dept Obstet & Gynecol, Columbus, OH 43210 USA. [Lu, Michael C.] Univ Calif Los Angeles, Sch Med, Dept Obstet & Gynecol, Los Angeles, CA 90024 USA. [Lu, Michael C.] Univ Calif Los Angeles, Sch Med, Dept Community Hlth Sci, Los Angeles, CA 90024 USA. [Lu, Michael C.] Univ Calif Los Angeles, Dept Obstet & Gynecol, Sch Publ Hlth, Los Angeles, CA 90024 USA. [Lu, Michael C.] Univ Calif Los Angeles, Sch Publ Hlth, Dept Community Hlth Sci, Los Angeles, CA 90024 USA. [Conry, Jeanne A.] Kaiser Permanente, Dept Womens Hlth, Roseville, CA USA. [Gibbs, Ronald S.] Univ Colorado, Hlth Sci Ctr, Dept Obstet & Gynecol, Denver, CO 80262 USA. RP Coonrod, DV (reprint author), Maricopa Cty Gen Hosp, Dept Obstet & Gynecol, OBGYN Dept, 2nd Floor Admin,2601 E Roosevelt St, Phoenix, AZ 85008 USA. EM dean_coonrod@MedProDoctors.com OI Jack, Brian/0000-0002-6497-2437 NR 119 TC 19 Z9 21 U1 0 U2 4 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD DEC PY 2008 VL 199 IS 6 SU 2 BP S296 EP S309 DI 10.1016/j.ajog.2008.08.062 PG 14 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 382BP UT WOS:000261580200006 PM 19081424 ER PT J AU Coonrod, DV Jack, BW Boggess, KA Long, R Conry, JA Cox, SN Cefalo, R Hunter, KD Pizzica, A Dunlop, AL AF Coonrod, Dean V. Jack, Brian W. Boggess, Kim A. Long, Richard Conry, Jeanne A. Cox, Shanna N. Cefalo, Robert Hunter, Kam D. Pizzica, Albert Dunlop, Anne L. TI The clinical content of preconception care: immunizations as part of preconception care SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE immunization; preconception care; vaccine ID CANCER-SOCIETY GUIDELINE; ADVISORY-COMMITTEE; PRACTICES ACIP; HUMAN-PAPILLOMAVIRUS; PREGNANT-WOMEN; INFLUENZA-A; RECOMMENDATIONS; VACCINE; VARICELLA; ANTIBODY AB Many vaccine-preventable diseases have serious consequences for the pregnant mother, the fetus, and the neonate. This article reviews the rationale and impact of including vaccinations as part of preconception care and provides recommendations for clinical care. Vaccinations that are recommended highly in preconception care include the hepatitis B and the measles, mumps, and rubella vaccines. The role of human papillomavirus, varicella, diphtheria, tetanus, and pertussis vaccinations as part of preconception care is also discussed. C1 [Coonrod, Dean V.] Maricopa Cty Gen Hosp, Dept Obstet & Gynecol, OBGYN Dept, Phoenix, AZ 85008 USA. [Hunter, Kam D.] Maricopa Cty Gen Hosp, Dept Family & Community Med, Phoenix, AZ 85008 USA. [Jack, Brian W.; Long, Richard] Boston Univ, Sch Med, Dept Family Med, Boston, MA 02118 USA. [Boggess, Kim A.; Cefalo, Robert] Univ N Carolina, Dept Obstet & Gynecol, Chapel Hill, NC USA. [Conry, Jeanne A.] Kaiser Permanente, Dept Womens Hlth, Roseville, CA USA. [Cox, Shanna N.] NCCDPHP, Div Reprod Hlth, Ctr Dis Control, Atlanta, GA USA. [Pizzica, Albert] Natl Perinatal Assoc, Harrisburg, PA USA. [Dunlop, Anne L.] Emory Univ, Sch Med, Dept Family & Prevent Med, Atlanta, GA USA. RP Coonrod, DV (reprint author), Maricopa Cty Gen Hosp, Dept Obstet & Gynecol, OBGYN Dept, 2nd Floor Admin,2601 E Roosevelt St, Phoenix, AZ 85008 USA. EM dean_coonrod@MedProDoctors.com OI Long, Richard/0000-0001-7521-4423; Jack, Brian/0000-0002-6497-2437 FU CMS [#1HOCMS030207 101] FX Dean V. Coonrod, MD, MPH, is a Grant Recipient from the March of Dimes Arizona Chapter to develop an internatal Care Clinic and has funding from CMS (#1HOCMS030207 101) working on compliance with the 6 week postpartum visit as a strategy to improve preconception care. Brian W. Jack, MD; Kim A. Boggess, MD; Richard Long, MD; Jeanne A. Conry, MD, PhD, Shanna N. Cox, MSPH; Robert Cefalo, MD, PhD; Kam D. Hunter, MD, PhD; Albert Pizzica, DO; and Anne L. Dunlop, MD, MPH have no conflict of interest including grants, honoraria, advisory board membership, or share holdings. NR 38 TC 10 Z9 12 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD DEC PY 2008 VL 199 IS 6 SU 2 BP S290 EP S295 DI 10.1016/j.ajog.2008.08.061 PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 382BP UT WOS:000261580200005 PM 19081423 ER PT J AU Floyd, RL Jack, BW Cefalo, R Atrash, H Mahoney, J Herron, A Husten, C Sokol, RJ AF Floyd, R. Louise Jack, Brian W. Cefalo, Robert Atrash, Hani Mahoney, Jeanne Herron, Anne Husten, Corinne Sokol, Robert J. TI The clinical content of preconception care: alcohol, tobacco, and illicit drug exposures SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE alcohol; preconception; substance abuse; women ID LOW-BIRTH-WEIGHT; BEHAVIORAL-COUNSELING INTERVENTIONS; SUBSTANCE USE DISORDERS; SPONTANEOUS-ABORTION; COCAINE DEPENDENCE; CIGARETTE-SMOKING; MATERNAL SMOKING; PREGNANT-WOMEN; UNITED-STATES; RISK AB Substance abuse poses significant health risks to childbearing-aged women in the United States and, for those who become pregnant, to their children. Alcohol is the most prevalent substance consumed by childbearing-aged women, followed by tobacco, and a variety of illicit drugs. Substance use in the preconception period predicts substance use during the prenatal period. Evidence-based methods for screening and intervening on harmful consumption patterns of these substances have been developed and are recommended for use in primary care settings for women who are pregnant, planning a pregnancy, or at risk for becoming pregnant. This report describes the scope of substance abuse in the target population and provides recommendations from the Clinical Working Group of the Select Panel on Preconception Care, Centers for Disease Control and Prevention, for addressing alcohol, tobacco, and illicit drug use among childbearing-aged women. C1 [Floyd, R. Louise] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Fetal Alcohol Prevent Team, Atlanta, GA 30345 USA. [Jack, Brian W.] Boston Med Ctr, Boston, MA USA. [Cefalo, Robert] Univ N Carolina, Sch Med, Chapel Hill, NC USA. [Mahoney, Jeanne] Amer Coll Obstetricians & Gynecologists, Washington, DC USA. [Herron, Anne] Substance Abuse & Mental Hlth Serv Adm, Rockville, MD USA. [Husten, Corinne] Partnership Prevent, Washington, DC USA. [Sokol, Robert J.] Wayne State Univ, Sch Med, Detroit, MI USA. RP Floyd, RL (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Fetal Alcohol Prevent Team, 1825 Century Ctr,E86, Atlanta, GA 30345 USA. EM rlf3@cdc.gov OI Jack, Brian/0000-0002-6497-2437 NR 70 TC 37 Z9 38 U1 4 U2 9 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD DEC PY 2008 VL 199 IS 6 SU 2 BP S333 EP S339 DI 10.1016/j.ajog.2008.09.018 PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 382BP UT WOS:000261580200009 PM 19081427 ER PT J AU Jack, BW Atrash, H Coonrod, DV Moos, MK O'Donnell, J Johnson, K AF Jack, Brian W. Atrash, Hani Coonrod, Dean V. Moos, Merry-K O'Donnell, Julie Johnson, Kay TI The clinical content of preconception care: an overview and preparation of this supplement SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE preconception care; pregnancy care AB In June 2005, the Select Panel on Preconception Care established implementation workgroups in 5 areas ( clinical, public health, consumer, policy and finance, and research and surveillance) to develop strategies for the implementation of the Centers for Disease Control and Prevention recommendations on preconception health and healthcare. In June 2006, members of the clinical workgroup asked the following questions: what are the clinical components of preconception care? What is the evidence for inclusion of each component in clinical activities? What health promotion package should be delivered as part of preconception care? Over the next 2 years, the 29 members of the clinical workgroup and > 30 expert consultants reviewed in depth > 80 topics that make up the content of the articles that are contained in this supplement. Topics were selected on the basis of the effect of preconception care on the health of the mother and/or infant, prevalence, and detectability. For each topic, the workgroup assigned a score for the strength of the evidence that supported its inclusion in preconception care and assigned a strength of the recommendation. This article summarizes the methods that were used to select and review each topic and provides a summary table of the recommendations. C1 [Jack, Brian W.; O'Donnell, Julie] Boston Univ, Sch Med, Dept Family Med, Boston, MA 02118 USA. [Atrash, Hani] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Coonrod, Dean V.] Maricopa Cty Gen Hosp, Dept Obstet & Gynecol, Phoenix, AZ USA. [Moos, Merry-K] Univ N Carolina, Sch Med, Dept Obstet & Gynecol, Chapel Hill, NC USA. [Johnson, Kay] Dartmouth Med Sch, Dept Pediat, Lebanon, NH USA. RP Jack, BW (reprint author), Boston Med Ctr, Dowling 5,Room 5309,1 BMC Pl, Boston, MA 02118 USA. EM brian.jack@bmc.org OI Jack, Brian/0000-0002-6497-2437 FU CMS [#1HOCMS030207 101] FX Brian W. Jack, MD; Hani Atrash, MD, MPH; Merry-K Moos, BSN, FNP, MPH; Julie O'Donnell, MPH; and Kay Johnson, MPH, EdM have no conflict of interest including grants, honoraria, advisory board membership, or share holdings. Dean V. Coonrod, MD, MPH, is a Grant Recipient from the March of Dimes Arizona Chapter to develop an internatal Care Clinic and has funding from CMS (#1HOCMS030207 101) working on compliance with the 6 week postpartum visit as a strategy to improve preconception care. NR 5 TC 73 Z9 76 U1 1 U2 6 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD DEC PY 2008 VL 199 IS 6 SU 2 BP S266 EP S279 DI 10.1016/j.ajog.2008.07.067 PG 14 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 382BP UT WOS:000261580200003 PM 19081421 ER PT J AU Vesco, K Stevens, V Rizzo, J Dietz, P Callaghan, W Bruce, C Bachman, D Hillier, T Hornbrook, M AF Vesco, Kimberly Stevens, Victor Rizzo, Joanne Dietz, Patricia Callaghan, William Bruce, Carol Bachman, Donald Hillier, Teresa Hornbrook, Mark TI NEONATAL AND MATERNAL OUTCOMES ASSOCIATED WITH LIMITED GESTATIONAL WEIGHT GAIN AMONG OBESE PREGNANT WOMEN SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 29th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY JAN 26-31, 2009 CL San Diego, CA SP Soc Mat Fetal Med C1 [Vesco, Kimberly; Stevens, Victor; Rizzo, Joanne; Bachman, Donald; Hillier, Teresa; Hornbrook, Mark] Kaiser Permanente Ctr Hlth Res, Portland, OR USA. [Dietz, Patricia; Callaghan, William; Bruce, Carol] Ctr Dis Control & Prevent, Atlanta, GA USA. RI Kattelmann, Kendra/E-8225-2013 NR 0 TC 0 Z9 0 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD DEC PY 2008 VL 199 IS 6 MA 185 BP S63 EP S63 DI 10.1016/j.ajog.2008.09.212 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 391AV UT WOS:000262205700185 ER PT J AU Grosse, SD Ouyang, L Collins, JS Green, D Dean, JH Stevenson, RE AF Grosse, Scott D. Ouyang, Lijing Collins, Julianne S. Green, Denise Dean, Jane H. Stevenson, Roger E. TI Economic Evaluation of a Neural Tube Defect Recurrence-Prevention Program SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID FOLIC-ACID SUPPLEMENTATION; ADJUSTED LIFE-YEAR; UNITED-STATES; COST-EFFECTIVENESS; PUBLIC-HEALTH; SPINA-BIFIDA; FORTIFICATION; WOMEN; INFANTS; RISK AB Background: Women with a pregnancy affected by a neural tube defect (NTD) are encouraged to take folic acid prior to a subsequent pregnancy, but it is unknown whether organized attempts to identify and counsel such women to prevent recurrent NTDs are cost effective. Methods: Data from the South Carolina recurrence-prevention program for October 2001-September 2002 were analyzed between October 2002 and December 2003 to calculate costs. Cost-effectiveness modeling of the program during 1992-2006 was conducted during 2007. Results were calculated for three scenarios based on recurrence risk, supplement use, and the effectiveness of folic acid in preventing recurrences. For each scenario, quality-adjusted life years (QALYs) were calculated separately using prevented NTD-affected live births; prevented NTD-affected births (including fetal deaths); and all prevented NTD-affected pregnancies. Results: The prevention program cost approximately $155,000 per year in 2003 dollars to protect 35 pregnancies and prevent approximately one NTD. The direct costs associated with all NTD depend on type and outcome, but are approximately $560,000 in 2003 dollars for a live birth with spina bifida. The base-case cost-effectiveness ratio was $39,600 per QALY gained front avoided NTD-affected live births and stillbirths, and $14,700 per QALY gained from the avoidance of all NTD-affected pregnancies. The baseline NTD recurrence risk and the use of folic acid Supplements by women who are at high risk for all NTD-affected pregnancy were influential parameters. Conclusions: The South Carolina NTD recurrence-prevention program appears comparable in cost effectiveness to other preventive services. Other states might consider including NTD recurrence prevention in birth defect-prevention programs. C1 [Grosse, Scott D.; Ouyang, Lijing; Green, Denise] CDC, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Collins, Julianne S.; Dean, Jane H.; Stevenson, Roger E.] Greenwood Genet Ctr, Greenwood, SC 29646 USA. RP Grosse, SD (reprint author), CDC, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS E-87, Atlanta, GA 30333 USA. EM sgrosse@cdc.gov FU CDC; South Carolina state agencies; Department of Disabilities and Special Needs; Department of Health and Human Services; Developmental Disability Council FX Initial funding for the NTD reccurence-prevention program in South Carolina came from the CDC. After CDC funding ended, the GGC obtained funding from various Sources, including three South Carolina state agencies: the Department of Disabilities and Special Needs, the Department of Health and Human Services, and the Developmental Disability Council. More recently, the South Carolina Blue Cross Blue Shield Foundation has provided operational Support. The authors thank Nancy Clary and Renee Betros, both of whom currently work for the South Carolina Birth Defects Program, for their help during this project. Also, they thank Bernadette Modell and Christopher Howson for calling attention to the issue of valuing all healthy births in economic evaluations of NTD prevention. NR 40 TC 25 Z9 28 U1 0 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD DEC PY 2008 VL 35 IS 6 BP 572 EP 577 DI 10.1016/j.amepre.2008.07.008 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 375ON UT WOS:000261123300006 PM 18845415 ER PT J AU Roux, L Pratt, M Tengs, TO Yore, MM Yanagawa, TL Van Den Bos, J Rutt, C Brownson, RC Powell, KE Heath, G Kohl, HW Teutsch, S Cawley, J Lee, IM West, L Buchner, DM AF Roux, Larissa Pratt, Michael Tengs, Tammy O. Yore, Michelle M. Yanagawa, Teri L. Van Den Bos, Jill Rutt, Candace Brownson, Ross C. Powell, Kenneth E. Heath, Gregory Kohl, Harold W., III Teutsch, Steven Cawley, John Lee, I-Min West, Linda Buchner, David M. TI Cost Effectiveness of Community-Based Physical Activity Interventions SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID CORONARY-HEART-DISEASE; ALL-CAUSE MORTALITY; PREVENTIVE-SERVICES; ECONOMIC COSTS; PUBLIC-HEALTH; OLDER-ADULTS; INACTIVITY; STROKE; QUALITY; ISSUES AB Background: Physical inactivity is associated with the increased risk of many chronic diseases. Such risks decrease with increases in physical activity. This study assessed the cost-effectiveness of population-wide strategies to promote physical activity in adults and followed disease incidence over a lifetime. Methods: A lifetime cost-effectiveness analysis from a societal perspective was conducted to estimate the costs, health gains, and cost-effectiveness (dollars per quality-adjusted life year [QALY] gained, relative to no intervention) of seven public health interventions to promote physical activity in a simulated cohort of healthy U.S. adults stratified by age, gender, and physical activity level. Interventions exemplifying each of four strategies strongly recommended by the Task Force on Community Preventive Services were evaluated: community-wide campaigns, individually adapted health behavior change, community social-support interventions, and the creation of or enhanced access to physical activity information and opportunities. Each intervention was compared to a no-intervention alternative. A systematic review of disease burden by physical activity status was used to assess the relative risk of five diseases (coronary heart disease, ischemic stroke, type 2 diabetes, breast cancer, and colorectal cancer) across a spectrum of physical activity levels. Other data were obtained from clinical trials, population-based surveys, and other published literature. Results: Cost-effectiveness ratios ranged between $14,000 and $69,000 per QALY gained, relative to no intervention. Results were sensitive to intervention-related costs and effect size. Conclusions: All of the evaluated physical activity interventions appeared to reduce disease incidence, to be cost-effective, and-compared with other well-accepted preventive strategies-to offer good value for money. The results Support using any of the seven evaluated interventions as part of public health efforts to promote physical activity. C1 [Lee, I-Min] Harvard Univ, Sch Med, Boston, MA USA. [Lee, I-Min] Harvard Univ, Brigham & Womens Hosp, Sch Publ Hlth, Boston, MA 02115 USA. [Brownson, Ross C.] St Louis Univ, Sch Publ Hlth, Prevent Res Ctr, St Louis, MO 63103 USA. [Heath, Gregory] Univ Tennessee Coll, Chattanooga, TN USA. [Teutsch, Steven] Merck & Co Inc, Outcomes Res & Management, W Point, VA USA. [Cawley, John] Cornell Univ, Dept Policy Anal & Management, Ithaca, NY USA. [Yanagawa, Teri L.] Stryker Instruments Mfg, Freiburg, Germany. [Tengs, Tammy O.; Van Den Bos, Jill] Milliman, Denver, CO USA. [Powell, Kenneth E.] Georgia Dept Human Resources, Div Publ Hlth, Epidemiol Branch, Chron Dis Injury & Environm Epidemiol Sect, Atlanta, GA USA. [Roux, Larissa; Pratt, Michael; Yore, Michelle M.; Yanagawa, Teri L.; Rutt, Candace; Heath, Gregory; Kohl, Harold W., III; West, Linda; Buchner, David M.] CDC, Div Nutr Phys Activ & Obes, Phys Activ & Hlth Branch, Atlanta, GA 30333 USA. RP Roux, L (reprint author), 5612 Elm St, Vancouver, BC V6N 1A4, Canada. EM lroux@ucalgary.ca RI Cawley, John/E-6734-2010 OI Cawley, John/0000-0002-4805-9883 FU Robert Wood Johnson Foundation; CDC Foundation FX This project integrated the expertise and dedication of both a large multidisciplinary team of accomplished investigators and policy leaders from academic centers across the U.S. and colleagues in the Physical Activity and Health Branch at the CDC. The authors acknowledge the work of The Robert Wood Johnson Foundation: Terry L. Bazzarre, Pamela G. Russo, Lori Melichar, Kathryn A. Thomas; CDC Foundation: C. Adam Brush, Connie L. Carmack, John R. Moore; UCLA School of Public Health, Los Angeles County, Department of Health Services: Brian Cole, Jonathan E. Fielding, Robert M. Kaplan; Research Triangle Institute/University of North Carolina Center of Excellence in Health Promotion Economics: Eric Finkelstein; Stanford Prevention Research Center at the Stanford University School of Medicine: William L. Haskell; University of Chicago: David Meltzer; The Physical Activity and Health Branch in the Division of Nutrition, Physical Activity and Obesity at the CDC: Chantelle Avery, Laura Biazzo, Mario Bracco, Casey J. Hannan, Carrie Heitzler, Diana Parra, and Guijing Wang; and Milliman Inc.; This scale of collaboration was made possible by the commitment and support of the Robert Wood Johnson Foundation and the CDC: Foundation and their project officers. The principal investigators of this study, Larissa Roux and Michael Pratt, had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. The views expressed in this paper are those of the authors, not the funder, and no conflicts of interest, financial or other, have been identified in the scope of this work. NR 65 TC 117 Z9 122 U1 6 U2 42 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD DEC PY 2008 VL 35 IS 6 BP 578 EP 588 DI 10.1016/j.amepre.2008.06.040 PG 11 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 375ON UT WOS:000261123300007 PM 19000846 ER PT J AU Wray, RJ Becker, SM Henderson, N Glik, D Jupka, K Middleton, S Henderson, C Drury, A Mitchell, EW AF Wray, Ricardo J. Becker, Steven M. Henderson, Neil Glik, Deborah Jupka, Keri Middleton, Sarah Henderson, Carson Drury, Allison Mitchell, Elizabeth W. TI Communicating With the Public About Emerging Health Threats: Lessons From the Pre-Event Message Development Project SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID RISK COMMUNICATION; TERRORIST ATTACK; ANTHRAX ATTACKS; BIOTERRORISM; RESPONSES; CONSEQUENCES; PERCEPTIONS; OUTBREAK; MEDIA AB Objectives. We sought to better understand the challenges of communicating with the public about emerging health threats, particularly threats involving toxic chemicals, biological agents, and radioactive materials. Methods. At the request of the Centers for Disease Control and Prevention, we formed an interdisciplinary consortium of investigative teams from 4 schools of public health. Over 2 years, the investigative teams conducted 79 focus group interviews with 884 participants and individual cognitive response interviews with 129 respondents, for a total sample of 1013 individuals. The investigative teams systematically compared their results with other published research in public health, risk communication, and emergency preparedness. Results. We found limited public understanding of emerging biological, chemical, and radioactive materials threats and of the differences between them; demand for concrete, accurate, and consistent information about actions needed for protection of self and family; active information seeking from media, local authorities, and selected national sources; and areas in which current emergency messaging can be improved. Conclusions. The public will respond to a threat situation by seeking protective information and taking self-protective action, underlining the critical role of effective communication in public health emergencies. (Am J Public Health. 2008; 98:2214-2222. doi:10.2105/AJPH.2006.107102) C1 [Wray, Ricardo J.; Jupka, Keri] St Louis Univ, Sch Publ Hlth, Hlth Commun Res Lab, St Louis, MO 63104 USA. [Becker, Steven M.; Middleton, Sarah] Univ Alabama, Sch Publ Hlth, Dept Environm Hlth Sci, Birmingham, AL 35294 USA. [Henderson, Neil; Henderson, Carson] Univ Oklahoma, Hlth Sci Ctr, Dept Hlth Promot Sci, Oklahoma City, OK USA. [Glik, Deborah; Drury, Allison] Univ Calif Los Angeles, Hlth & Media Res Grp, Sch Publ Hlth, Los Angeles, CA USA. [Mitchell, Elizabeth W.] CDC, Natl Ctr Hlth Marketing, Div Emergency Commun, Atlanta, GA 30333 USA. RP Wray, RJ (reprint author), St Louis Univ, Sch Publ Hlth, Hlth Commun Res Lab, 3545 Lafayette Ave,Room 411, St Louis, MO 63104 USA. EM wray@slu.edu FU CDC [A1104-21/21, A1104-21/23] FX Thus study was supported by the CDC (grants A1104-21/21 and A1104-21/23). NR 69 TC 49 Z9 50 U1 5 U2 13 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD DEC PY 2008 VL 98 IS 12 BP 2214 EP 2222 DI 10.2105/AJPH.2006.107102 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 378GP UT WOS:000261309500024 PM 18382011 ER PT J AU Sheth, AN Russo, ET Menon, M Kudzala, AC Kelly, JD Weinger, M Sebunya, K Masuku, H Wannemuehler, K Quick, R AF Sheth, Anandi N. Russo, Elizabeth T. Menon, Manoj Kudzala, Amose C. Kelly, John D. Weinger, Merri Sebunya, Kiwe Masuku, Humphreys Wannemuehler, Kathleen Quick, Rob TI SUCCESSFUL PROMOTION OF WATER TREATMENT AND HAND HYGIENE THROUGH A PILOT CLINIC-BASED INTERVENTION FOR PREGNANT WOMEN SEEKING ANTENATAL CARE: MALAWI, MAY 2007-MARCH 2008 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Sheth, Anandi N.; Russo, Elizabeth T.; Menon, Manoj; Kelly, John D.; Wannemuehler, Kathleen; Quick, Rob] Ctr Dis Control & Prevent, Atlanta, GA USA. [Kudzala, Amose C.; Sebunya, Kiwe] United Nations Childrens Fund, Lilongwe, Malawi. [Weinger, Merri] US Agcy Int Dev, Washington, DC 20523 USA. [Masuku, Humphreys] Govt Malawi Minist Hlth, Lilongwe, Malawi. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 16 BP 5 EP 6 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600017 ER PT J AU Luby, SP Agboatwalla, M Bowen, A Hoekstra, RM AF Luby, Stephen P. Agboatwalla, Mubina Bowen, Anna Hoekstra, Robert M. TI DIFFICULTIES IN SUSTAINING IMPROVED HANDWASHING BEHAVIOR, KARACHI, PAKISTAN SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Luby, Stephen P.] ICDDRB, Dhaka, Bangladesh. [Agboatwalla, Mubina] HOPE, Karachi, Pakistan. [Bowen, Anna; Hoekstra, Robert M.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 20 BP 7 EP 7 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600021 ER PT J AU Shargie, EB Graves, PM Getachew, A Hwang, J Richards, FO Emerson, PM Gebre, T Mosher, AW Encleshaw, T Ejigsemahu, Y Hailemariam, A Tenaw, E Miller, J Yohannes, AM Ngondi, J Jima, D Tadesse, Z Ghebreyesus, TA AF Shargie, Estifanos Biru Graves, Patricia M. Getachew, Asefaw Hwang, Jimee Richards, Frank O. Emerson, Paul M. Gebre, Teshome Mosher, Aryc W. Encleshaw, Tekola Ejigsemahu, Yeshewamebrat Hailemariam, Afework Tenaw, Eskinder Miller, John Yohannes, Ambachew Medhin Ngondi, Jeremiah Jima, Daddi Tadesse, Zerihun Ghebreyesus, Tedros Adhanom TI RAPID INCREASE IN COVERAGE WITH LONG-LASTING INSECTICIDAL NETS IN AMHARA, OROMIA AND SNNP REGIONS OF ETHIOPIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Shargie, Estifanos Biru; Getachew, Asefaw; Gebre, Teshome; Encleshaw, Tekola; Ejigsemahu, Yeshewamebrat] Carter Ctr, Addis Ababa, Ethiopia. [Graves, Patricia M.; Richards, Frank O.; Emerson, Paul M.; Mosher, Aryc W.] Emory Univ, Carter Ctr, Atlanta, GA 30322 USA. [Hwang, Jimee] Ctr Dis Control & Prevent, Atlanta, GA USA. [Hailemariam, Afework; Jima, Daddi; Tadesse, Zerihun; Ghebreyesus, Tedros Adhanom] Minist Hlth, Addis Ababa, Ethiopia. [Tenaw, Eskinder] Cent Stat Agcy, Addis Ababa, Ethiopia. [Miller, John] Malaria Control & Evaluat Partnership Africa, Lusaka, Zambia. [Yohannes, Ambachew Medhin] WHO, Addis Ababa, Ethiopia. [Ngondi, Jeremiah] Univ Cambridge, Cambridge, England. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 35 BP 11 EP 11 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600036 ER PT J AU Hayden, MH Zielinski-Gutierrez, E Uejio, C Barrera, R Lopez, JLR Ramirez, J Amador, M Diaz, A Waterman, S AF Hayden, Mary H. Zielinski-Gutierrez, Emily Uejio, Christopher Barrera, Roberto Lopez, Jose Luis Robles Ramirez, Josue Amador, Manuel Diaz, Annette Waterman, Stephen TI WASTE TIRES AND RISK FOR DENGUE FEVER INFECTION IN BROWNSVILLE, TEXAS AND MATAMOROS, TAMAULIPAS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Hayden, Mary H.] Natl Ctr Atmospher Res, Boulder, CO 80307 USA. [Zielinski-Gutierrez, Emily] Ctr Dis Control & Prevent, DVBID, Ft Collins, CO USA. [Uejio, Christopher] Univ Wisconsin, Madison, WI USA. [Barrera, Roberto; Amador, Manuel; Diaz, Annette] Ctr Dis Control & Prevent, DVBID, San Juan, PR USA. [Lopez, Jose Luis Robles] Jurisdicc Sanitaria III, Matamoros, Mexico. [Ramirez, Josue] Brownsville Dept Hlth, Brownsville, TX USA. [Waterman, Stephen] Ctr Dis Control & Prevent, DGMQ, San Diego, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 57 BP 18 EP 18 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600058 ER PT J AU Thwing, JI Mihigo, J Pataca, AF Saute, F Ferreira, C Fortes, F Ponce-de-Leon, G de Oliveira, AM Newman, R AF Thwing, Julie I. Mihigo, Jules Pataca, Alexandra F. Saute, Francisco Ferreira, Carolina Fortes, Filomeno Ponce-de-Leon, Gabriel Macedo de Oliveira, Alexandre Newman, Robert TI HEALTH FACILITY-BASED ASSESSMENT OF THE BURDEN OF MALARIA IN LUANDA, ANGOLA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Thwing, Julie I.; Mihigo, Jules; Ponce-de-Leon, Gabriel; Macedo de Oliveira, Alexandre; Newman, Robert] Ctr Dis Control & Prevent, Atlanta, GA USA. [Pataca, Alexandra F.] Direccao Prov Saude, Luanda, Angola. [Saute, Francisco] US Agcy Int Dev, Luanda, Angola. [Ferreira, Carolina] Inst Nacl Saude Publ, Luanda, Angola. [Fortes, Filomeno] Natl Malaria Control Program, Luanda, Angola. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 SU S MA 71 BP 21 EP 21 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600072 ER PT J AU Thwing, JI Odero, C Odhiambo, F Kariuki, S Roper, C Ord, R McMorrow, M Kachur, SP Slutsker, L Vulule, J Newman, R Hamel, M Desai, M AF Thwing, Julie I. Odero, Christopher Odhiambo, Frank Kariuki, Simon Roper, Cally Ord, Rosalyn McMorrow, Meredith Kachur, S. Patrick Slutsker, Lawrence Vulule, John Newman, Robert Hamel, Mary Desai, Meghna TI IN-VIVO EFFICACY OF AMODIAQUINE-ARTESUNATE FOR TREATMENT OF UNCOMPLICATED PLASMODIUM FALCIPARUM MALARIA IN CHILDREN IN WESTERN KENYA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Thwing, Julie I.; McMorrow, Meredith; Kachur, S. Patrick; Slutsker, Lawrence; Newman, Robert; Desai, Meghna] Ctr Dis Control & Prevent, Atlanta, GA USA. [Odero, Christopher; Odhiambo, Frank; Kariuki, Simon; Hamel, Mary] Kenya Govt Med Res Ctr, Ctr Dis Control & Prevent, Kisumu, Kenya. [Roper, Cally; Ord, Rosalyn] London Sch Hyg & Trop Med, London WC1, England. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 SU S MA 72 BP 22 EP 22 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600073 ER PT J AU Thwing, JI Odero, C Odhiambo, F Kariuki, S Roper, C Ord, R McMorrow, M Kachur, SP Slutsker, L Vulule, J Newman, R Hamel, M Desai, M AF Thwing, Julie I. Odero, Christopher Odhiambo, Frank Kariuki, Simon Roper, Cally Ord, Rosalyn McMorrow, Meredith Kachur, S. Patrick Slutsker, Lawrence Vulule, John Newman, Robert Hamel, Mary Desai, Meghna TI HIV, GRAVIDITY AND MALARIA DURING PREGNANCY IN SOUTHERN MALAWI: ANTAGONISTIC INTERACTION? SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Thwing, Julie I.; McMorrow, Meredith; Kachur, S. Patrick; Slutsker, Lawrence; Newman, Robert; Desai, Meghna] Ctr Dis Control & Prevent, Atlanta, GA USA. [Odero, Christopher; Odhiambo, Frank; Kariuki, Simon; Hamel, Mary] Kenya Govt Med Res Ctr, Ctr Dis Control & Prevent, Kisumu, Kenya. [Roper, Cally; Ord, Rosalyn] London Sch Hyg & Trop Med, London WC1, England. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 SU S MA 75 BP 22 EP 23 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600076 ER PT J AU Mpimbaza, A Katureebe, A Odiit, A Quick, L Ratcliffe, A Filler, S Kamya, MR Staedke, SG AF Mpimbaza, Arthur Katureebe, Agaba Odiit, Amos Quick, Linda Ratcliffe, Amy Filler, Scott Kamya, Moses R. Staedke, Sarah G. TI QUALITY OF MEDICAL RECORDS: RESULTS FROM AN AUDIT OF SIX HOSPITALS IN UGANDA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Mpimbaza, Arthur; Katureebe, Agaba] Uganda Malaria Surveillance Project, Kampala, Uganda. [Odiit, Amos] Mulago Hosp, Kampala, Uganda. [Quick, Linda; Ratcliffe, Amy; Filler, Scott] Ctr Dis Control & Prevent, Atlanta, GA USA. [Kamya, Moses R.] Makerere Univ, Kampala, Uganda. [Staedke, Sarah G.] London Sch Hyg & Trop Med, London WC1, England. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 93 BP 27 EP 28 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600094 ER PT J AU Arvelo, W Reyes, L Lopez, B Parsons, M Kerin, T Widdowson, MA Pezzarossi, N Mintz, E Lindblade, K AF Arvelo, Wences Reyes, Lissette Lopez, Beatriz Parsons, Michele Kerin, Tara Widdowson, Marc-Alain Pezzarossi, Nancy Mintz, Eric Lindblade, Kimberly TI MANAGEMENT OF CHILDHOOD DIARRHEAL DISEASE IN GONDAR, ETHIOPIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Arvelo, Wences; Reyes, Lissette; Lopez, Beatriz] Univ Valle Guatemala, Guatemala City, Guatemala. [Parsons, Michele; Kerin, Tara; Widdowson, Marc-Alain; Mintz, Eric; Lindblade, Kimberly] Ctr Dis Control & Prevent, Atlanta, GA USA. [Pezzarossi, Nancy] Minist Publ Hlth & Social Welfare Guatemala, Guatemala City, Guatemala. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 SU S MA 97 BP 29 EP 29 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600098 ER PT J AU Arvelo, W Reyes, L Lopez, B Parsons, M Kerin, T Widdowson, MA Pezzarossi, N Mintz, E Lindblade, K AF Arvelo, Wences Reyes, Lissette Lopez, Beatriz Parsons, Michele Kerin, Tara Widdowson, Marc-Alain Pezzarossi, Nancy Mintz, Eric Lindblade, Kimberly TI DIARRHEA OUTBREAK WITH HIGH MORTALITY AMONG YOUNG CHILDREN IN SANTA ROSA, GUATEMALA-2008 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Arvelo, Wences; Reyes, Lissette; Lopez, Beatriz] Univ Valle Guatemala, Guatemala City, Guatemala. [Parsons, Michele; Kerin, Tara; Widdowson, Marc-Alain; Mintz, Eric; Lindblade, Kimberly] Ctr Dis Control & Prevent, Atlanta, GA USA. [Pezzarossi, Nancy] Minist Publ Hlth & Social Welfare Guatemala, Guatemala City, Guatemala. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 SU S MA 98 BP 29 EP 29 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600099 ER PT J AU Sodha, SV Menon, M Trivedi, K Ati, A Figueroa, ME Ainslie, R Wannemuehler, K Quick, R AF Sodha, Samir V. Menon, Manoj Trivedi, Kavita Ati, Abigael Figueroa, Maria Elena Ainslie, Robert Wannemuehler, Kathleen Quick, Rob TI BARRIERS TO MAINTAINING THE MICROBIOLOGIC QUALITY OF DRINKING WATER, SOUTH SULAWESI, INDONESIA: BANTAENG AND MAROS DISTRICTS, 2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Sodha, Samir V.; Menon, Manoj; Trivedi, Kavita; Wannemuehler, Kathleen; Quick, Rob] Ctr Dis Control & Prevent, Atlanta, GA USA. [Ati, Abigael; Figueroa, Maria Elena; Ainslie, Robert] Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Commun Program, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 99 BP 29 EP 29 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600100 ER PT J AU Bolas, S Olson, CK Naik, K Mathingau, A Odidi, B Blum, LS Feikin, DR Laserson, KF Wamae, AW Breiman, RF Ram, PK AF Bolas, Stefanie Olson, Christine K. Naik, Kinnery Mathingau, Alice Odidi, Beatrice Blum, Lauren S. Feikin, Daniel R. Laserson, Kayla F. Wamae, Annah W. Breiman, Robert F. Ram, Pavani Kalluri TI AVAILABILITY OF ORAL REHYDRATION SOLUTION PACKETS AT SMALL SHOPS IN TWO AREAS OF KENYA, 2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Bolas, Stefanie; Ram, Pavani Kalluri] SUNY Buffalo, Buffalo, NY 14260 USA. [Olson, Christine K.; Naik, Kinnery] Ctr Dis Control & Prevent, Atlanta, GA USA. [Mathingau, Alice; Odidi, Beatrice; Blum, Lauren S.; Feikin, Daniel R.; Breiman, Robert F.] CDC KEMRI, Int Emerging Infect Program, Kisumu, Kenya. [Laserson, Kayla F.] CDC KEMRI, Ctr Global Hlth Res, Kisumu, Kenya. [Wamae, Annah W.] Republ Kenya Minist Hlth, Nairobi, Kenya. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 100 BP 30 EP 30 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600101 ER PT J AU Boore, AL Naik, K Olson, CK Blum, LS Mathingau, A Odidi, B Feikin, DR Laserson, KF Wamae, AW Breiman, RF Ram, PK AF Boore, Amy L. Naik, Kinnery Olson, Christine K. Blum, Lauren S. Mathingau, Alice Odidi, Beatrice Feikin, Daniel R. Laserson, Kayla F. Wamae, Annah W. Breiman, Robert F. Ram, Pavani Kalluri TI INAPPROPRIATE RECOMMENDATION OF ANTIMICROBIAL AGENTS FOR TREATMENT OF WATERY DIARRHEA BY HEALTH WORKERS IN KENYA, 2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Boore, Amy L.; Naik, Kinnery; Olson, Christine K.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Blum, Lauren S.; Mathingau, Alice; Odidi, Beatrice; Feikin, Daniel R.; Breiman, Robert F.] Kenya Govt Med Res Ctr, Ctr Dis Control & Prevent, Int Emerging Infect Program, Kisumu, Kenya. [Laserson, Kayla F.] Ctr Global Hlth Res, Kenya Med Res Inst, Ctr Dis Control & Prevent, Kisumu, Kenya. [Wamae, Annah W.] Republ Kenya Minist Hlth, Nairobi, Kenya. [Ram, Pavani Kalluri] SUNY Buffalo, Buffalo, NY 14260 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 102 BP 30 EP 30 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600103 ER PT J AU Ram, PK Olson, CK Naik, K Blum, LS Boore, AL Mathingau, A Odidi, B Feikin, DR Laserson, KF Wamae, AW Breiman, RF AF Ram, Pavani Kalluri Olson, Christine K. Naik, Kinnery Blum, Lauren S. Boore, Amy L. Mathingau, Alice Odidi, Beatrice Feikin, Daniel R. Laserson, Kayla F. Wamae, Annah W. Breiman, Robert F. TI RECOMMENDATION OF ORAL REHYDRATION SOLUTION FOR DIARRHEA CASE MANAGEMENT BY PHARMACY WORKERS IN KENYA, 2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Ram, Pavani Kalluri] SUNY Buffalo, Buffalo, NY 14260 USA. [Olson, Christine K.; Naik, Kinnery; Boore, Amy L.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Blum, Lauren S.; Mathingau, Alice; Odidi, Beatrice; Feikin, Daniel R.] CDC KEMRI, Int Emerging Infect Program, Kisumu, Kenya. [Laserson, Kayla F.] CDC KEMRI, Ctr Global Hlth Res, Kisumu, Kenya. [Wamae, Annah W.] Republ Kenya Minist Hlth, Nairobi, Kenya. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 101 BP 30 EP 30 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600102 ER PT J AU Juliao, PC Teates, K Liang, A Were, V Obure, A Suchdev, P Ruth, L Hoekstra, M Quick, R AF Juliao, Patricia C. Teates, Kathryn Liang, Alison Were, Vincent Obure, Alfredo Suchdev, Parminder Ruth, Laird Hoekstra, Mike Quick, Rob TI THE IMPACT OF A COMMUNITY-BASED PROGRAM TO PROMOTE POINT-OF USE WATER CHLORINATION PRODUCTS AND REDUCE DIARRHEAL RATES IN RURAL WESTERN KENYA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Juliao, Patricia C.; Teates, Kathryn; Suchdev, Parminder; Ruth, Laird; Hoekstra, Mike; Quick, Rob] Ctr Dis Control & Prevent, Atlanta, GA USA. [Liang, Alison] Emory Univ, Atlanta, GA 30322 USA. [Were, Vincent; Obure, Alfredo] Kenya Govt Med Res Ctr, Kisumu, Kenya. RI Suchdev, Parmi/K-4851-2012 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 106 BP 31 EP 32 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600107 ER PT J AU McElroy, KL Santiago, GA Amador, M Lennon, NJ Henn, MR Sun, W Barrera, R Munoz-Jordan, J AF McElroy, Kate L. Santiago, Gilberto A. Amador, Manuel Lennon, Niall J. Henn, Matthew R. Sun, Wellington Barrera, Roberto Munoz-Jordan, Jorge TI DEFINING THE RELATIONSHIP BETWEEN DENGUE VIRUS TYPE-2 VIRAL GENETICS AND EPIDEMIC POTENTIAL IN PUERTO RICO, 1986-2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Lennon, Niall J.; Henn, Matthew R.] Broad Inst, Cambridge, MA USA. [McElroy, Kate L.; Santiago, Gilberto A.; Amador, Manuel; Sun, Wellington; Barrera, Roberto; Munoz-Jordan, Jorge] Ctr Dis Control & Prevent, San Juan, PR USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 123 BP 36 EP 37 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600124 ER PT J AU Rout, J Rao, G Fox, LM AF Rout, Jonathan Rao, Grace Fox, LeAnne M. TI BURDEN OF LYMPHEDEMA DUE TO LYMPHATIC FILARIASIS - ORISSA STATE, INDIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Rout, Jonathan; Rao, Grace] Churchs Auxiliary Social Act CASA, Bhubaneswar, Orissa, India. [Fox, LeAnne M.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 136 BP 40 EP 41 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600137 ER PT J AU Boyd, A Won, KY Vosswinkel, K Laney, SJ Williams, SA Pilotte, N Streit, T de Rochars, MB Lammie, PJ AF Boyd, Alexis Won, Kimberly Y. Vosswinkel, Katherine Laney, Sandra J. Williams, Steven A. Pilotte, Nils Streit, Thomas de Rochars, Madsen Beau Lammie, Patrick J. TI TRANSMISSION HOTSPOTS AND FACTORS ASSOCIATED WITH CONTINUING TRANSMISSION OF LYMPHATIC FILARIASIS IN LEOGANE, HAITI SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Boyd, Alexis; Won, Kimberly Y.; Lammie, Patrick J.] Ctr Dis Control, Atlanta, GA 30333 USA. [Vosswinkel, Katherine; Streit, Thomas] Univ Notre Dame, Notre Dame, IN 46556 USA. [Laney, Sandra J.; Williams, Steven A.; Pilotte, Nils] Smith Coll, Northampton, MA 01063 USA. [de Rochars, Madsen Beau] Hop Ste Croix, Leogane, Haiti. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 141 BP 42 EP 42 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600142 ER PT J AU Metta, E Mbuyita, S Kimweri, A Kahigwa, E Allen, DR Abdulla, S Kachur, SP AF Metta, Emmy Mbuyita, Seleman Kimweri, Angela Kahigwa, Elizeus Allen, Denise Roth Abdulla, Salim Kachur, S. Patrick TI IMPLEMENTATION OF ARTEMEMTHER LUMEFANTRINE IN TANZANIA: EARLY LESSONS AND EXPERIENCES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Metta, Emmy; Mbuyita, Seleman; Kimweri, Angela; Kahigwa, Elizeus; Abdulla, Salim] IHRDC, Dar Es Salaam, Tanzania. [Allen, Denise Roth; Kachur, S. Patrick] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 175 BP 52 EP 52 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600176 ER PT J AU McCollum, AM Tahar, R Basco, LK Udhayakumar, V Escalante, AA AF McCollum, Andrea M. Tahar, Rachida Basco, Leonardo K. Udhayakumar, Venkatachalam Escalante, Ananias A. TI HITCHHIKING AND SELECTIVE SWEEPS OF PLASMODIUM FALCIPARUM SULFADOXINE AND PYRIMETHAMINE RESISTANT ALLELES IN CAMEROON SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [McCollum, Andrea M.; Udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Atlanta, GA USA. [Tahar, Rachida; Basco, Leonardo K.] IRD, Unite Rech Paludol Afrotrop, Yaounde, Cameroon. [Tahar, Rachida; Basco, Leonardo K.] OCEAC, Lab Rech Paludisme, Yaounde, Cameroon. [Escalante, Ananias A.] Arizona State Univ, Tempe, AZ USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 198 BP 58 EP 59 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600199 ER PT J AU Soberon, VR Salas, CJ Santolalla, ML McCollum, AM Udhayakumar, V Lucas, CM Bacon, DJ AF Soberon, Valeria R. Salas, Carola J. Santolalla, Meddly L. McCollum, Andrea M. Udhayakumar, Venkatachalam Lucas, Carmen M. Bacon, David J. TI IDENTIFICATION OF MOLECULAR MARKERS IN PLASMODIUM FALCIPARUM ISOLATES ASSOCIATED TO MEFLOQUINE AND ARTESUNATE DRUG RESITANCE IN THE PERUVIAN AMAZON BASIN SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Soberon, Valeria R.; Salas, Carola J.; Santolalla, Meddly L.; Lucas, Carmen M.; Bacon, David J.] USN, Naval Med Res Ctr Detachment, Lima, Peru. [McCollum, Andrea M.; Udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 197 BP 58 EP 58 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600198 ER PT J AU Hwang, J Arguin, P Kachur, SP Wolkon, A Greenfield, J Kiptui, R Slutsker, L Akhwale, W Hightower, AW AF Hwang, Jimee Arguin, Paul Kachur, S. Patrick Wolkon, Adam Greenfield, Joann Kiptui, Rebecca Slutsker, Laurence Akhwale, Willis Hightower, Allen W. TI THE NET EFFECT OF NUMBERS: FACTORS ASSOCIATED WITH USE OF INSECTICIDE-TREATED NETS IN KENYA AFTER MASS DISTRIBUTION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Hwang, Jimee; Arguin, Paul; Kachur, S. Patrick; Wolkon, Adam; Slutsker, Laurence] Ctr Dis Control & Prevent, Atlanta, GA USA. [Greenfield, Joann] WHO, Nairobi, Kenya. [Kiptui, Rebecca; Akhwale, Willis] Div Malaria Control, Nairobi, Kenya. [Hightower, Allen W.] Ctr Dis Control & Prevent, Nairobi, Kenya. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 212 BP 62 EP 63 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600213 ER PT J AU Gatei, W Kariuki, S Hawley, W ter Kuile, F Terlouw, D Phillips-Howard, P Nahlen, B Gimnig, J Lindblade, K Walker, E Williamson, J Hamel, M Escalante, A Slutsker, L Shi, YP AF Gatei, Wangeci Kariuki, Simon Hawley, William ter Kuile, Feiko Terlouw, Dianne Phillips-Howard, Penny Nahlen, Bernard Gimnig, John Lindblade, Kim Walker, Edward Williamson, John Hamel, Mary Escalante, Ananias Slutsker, Laurence Shi, Ya Ping TI EFFECTS OF INSECTICIDE TREATED BEDNETS (ITNS) ON THE GENETIC DIVERSITY OF PLASMODIUM FALCIPARUM PARASITES IN A MALARIA HOLOENDEMIC AREA OF WESTERN KENYA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Gatei, Wangeci] Ctr Dis Control, Div Parasit Dis, Malaria Branch, Atlanta, GA 30333 USA. [Gatei, Wangeci] Atlanta Res & Educ Fdn, Atlanta, GA USA. [Kariuki, Simon] Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Kisumu, Kenya. [Hawley, William; Phillips-Howard, Penny; Gimnig, John; Lindblade, Kim; Williamson, John; Hamel, Mary; Slutsker, Laurence; Shi, Ya Ping] Ctr Dis Control & Prevent, Div Parasit Dis, Malaria Branch, Atlanta, GA USA. [Terlouw, Dianne] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England. [Phillips-Howard, Penny; Hamel, Mary] Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Atlanta, GA USA. [Nahlen, Bernard] Presidents Malaria Initiat, Washington, DC USA. [Walker, Edward] Michigan State Univ, E Lansing, MI 48824 USA. [Escalante, Ananias] Arizona State Univ, Tempe, AZ USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 214 BP 63 EP 63 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600215 ER PT J AU Jima, D Hwang, J Getachew, A Bilak, H Shargie, EB Gebre, T Fentie, G Wolkon, A Filler, S Reithinger, R Emerson, PM Encleshaw, T Mosher, AW Richards, FO Tenaw, E Yohannes, AM Gausi, K Miller, J Robb-McCord, J Steketee, R Graves, PM Tadesse, Z Ghebreyesus, TA AF Jima, Daddi Hwang, Jimee Getachew, Asefaw Bilak, Hana Shargie, Estifanos Biru Gebre, Teshome Fentie, Gashu Wolkon, Adam Filler, Scott Reithinger, Richard Emerson, Paul M. Encleshaw, Tekola Mosher, Aryc W. Richards, Frank O. Tenaw, Eskindir Yohannes, Ambachew M. Gausi, Khoti Miller, John Robb-McCord, Judith Steketee, Richard Graves, Patricia M. Tadesse, Zerihun Ghebreyesus, Tedros Adhanom TI ACHIEVEMENTS IN MALARIA CONTROL IN ETHIOPIA: RESULTS FROM MALARIA INDICATOR SURVEY, 2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Jima, Daddi; Tadesse, Zerihun] Minist Hlth, Dis Prevent & Control Dept, Addis Ababa, Ethiopia. [Hwang, Jimee; Wolkon, Adam; Filler, Scott] Ctr Dis Control & Prevent, Atlanta, GA USA. [Getachew, Asefaw; Shargie, Estifanos Biru; Gebre, Teshome; Fentie, Gashu; Encleshaw, Tekola] Carter Ctr, Addis Ababa, Ethiopia. [Bilak, Hana; Miller, John; Robb-McCord, Judith; Steketee, Richard] PATH, Malaria Control & Evaluat Partnership Afr, Seattle, WA USA. [Reithinger, Richard; Emerson, Paul M.] US Agcy Int Dev, Addis Ababa, Ethiopia. [Mosher, Aryc W.; Richards, Frank O.; Graves, Patricia M.] Emory Univ, Carter Ctr, Atlanta, GA 30322 USA. [Tenaw, Eskindir] Cent Stat Agcy, Addis Ababa, Ethiopia. [Yohannes, Ambachew M.] WHO, Addis Ababa, Ethiopia. [Gausi, Khoti] WHO, Harare, Zimbabwe. RI Graves, Patricia/J-8691-2014 OI Graves, Patricia/0000-0002-5215-3901 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 216 BP 64 EP 64 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600217 ER PT J AU Kent, RJ Morales, ME Komar, N AF Kent, Rebekah J. Morales, Maria Eugenia Komar, Nicholas TI HOST PREFERENCE OF POTENTIAL WEST NILE VIRUS VECTORS IN GUATEMALA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Kent, Rebekah J.; Komar, Nicholas] Ctr Dis Control & Prevent, Ft Collins, CO USA. [Morales, Maria Eugenia] Univ Valle Guatemala, Guatemala City, Guatemala. RI Kading, Rebekah/E-5633-2017 OI Kading, Rebekah/0000-0002-4996-915X NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 262 BP 76 EP 76 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600262 ER PT J AU Idoko, OT Okoko, BJ Sow, S Tapia, M Preziosi, MP Marchetti, E Haidara, FC Martellet, L Chaumont, J Parulekar, V Plikaytis, B Borrow, R Carlone, G Adegbola, R Preaud, JM Kulkarni, P Kapre, S Jadhav, S Hassan-King, M LaForce, M Viviani, S Findlow, H Elie, C AF Idoko, Olubukola T. Okoko, Brown J. Sow, Samba Tapia, Milagritos Preziosi, Marie-Pierre Marchetti, Elisa Haidara, Fadima C. Martellet, Lionel Chaumont, Julie Parulekar, Varsha Plikaytis, Brian Borrow, Ray Carlone, George Adegbola, Richard Preaud, Jean-Marie Kulkarni, Prasad Kapre, Subhash Jadhav, Suresh Hassan-King, Musa LaForce, Marc Viviani, Simonetta Findlow, Helen Elie, Cheryl TI A PHASE II, OBSERVER BLIND, RANDOMIZED, CONTROLLED STUDY TO EVALUATE THE SAFETY, IMMUNOGENICITY AND IMMUNOLOGICAL MEMORY OF A BOOSTER DOSE OF A NEW GROUP A MENINGOCOCCAL CONJUGATE VACCINE (MENAFRIVAC (TM)) IN HEALTHY AFRICAN CHILDREN PREVIOUSLY PRIMED AT 12-23 MONTHS OF AGE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Idoko, Olubukola T.; Okoko, Brown J.; Adegbola, Richard] MRC, Banjul, Gambia. [Sow, Samba; Tapia, Milagritos; Haidara, Fadima C.] CVD Mali, Bamako, Mali. [Preziosi, Marie-Pierre] WHO, Initiat Vaccine Res, Meningitis Vaccine Project, CH-1211 Geneva, Switzerland. [Marchetti, Elisa; Martellet, Lionel; Chaumont, Julie; Preaud, Jean-Marie; Hassan-King, Musa; LaForce, Marc; Viviani, Simonetta] PATH, Meningitis Vaccine Project, Ferney Voltaire, France. [Parulekar, Varsha] iGATE Clin Res Unit, Bombay, Maharashtra, India. [Plikaytis, Brian; Carlone, George; Elie, Cheryl] Ctr Dis Control & Prevent, Atlanta, GA USA. [Borrow, Ray; Findlow, Helen] Hlth Protect Agcy, Vaccine Evaluat Unit, Manchester, Lancs, England. [Kulkarni, Prasad; Kapre, Subhash; Jadhav, Suresh] SIIL, Pune, Maharashtra, India. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 264 BP 77 EP 77 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600265 ER PT J AU Adjemian, J Krebs, J Mandel, E McQuiston, J AF Adjemian, Jennifer Krebs, John Mandel, Eric McQuiston, Jennifer TI SPATIAL CLUSTERING BY DISEASE SEVERITY AMONG ROCKY MOUNTAIN SPOTTED FEVER CASES IN THE UNITED STATES, 2001-2005 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Adjemian, Jennifer; Krebs, John; Mandel, Eric; McQuiston, Jennifer] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 268 BP 78 EP 79 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600269 ER PT J AU Kosoy, MY Bai, Y Kuzmin, IV Niezgoda, M Franka, R Agwanda, B Breiman, RF Rupprecht, CE AF Kosoy, Michael Y. Bai, Ying Kuzmin, Ivan V. Niezgoda, Michael Franka, Richard Agwanda, Bernard Breiman, Robert F. Rupprecht, Charles E. TI DISCOVERY OF NEW BARTONELLA SPECIES IN BATS FROM KENYA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Kosoy, Michael Y.; Bai, Ying] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO USA. [Kuzmin, Ivan V.; Niezgoda, Michael; Franka, Richard; Rupprecht, Charles E.] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Atlanta, GA USA. [Agwanda, Bernard] Natl Museums Kenya, Mammal Sect, Nairobi, Kenya. [Breiman, Robert F.] CDC Kenya, Global Dis Detect Div, Nairobi, Kenya. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 265 BP 78 EP 78 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600266 ER PT J AU Murray, CK Pimentel, G Parker, T Beckius, ML Samir, A Rhman, BA Mende, K Galloway, RL Hospenthal, DR AF Murray, Clinton K. Pimentel, Guillermo Parker, Tina Beckius, Miriam L. Samir, Ahmed Rhman, Bassern Abdel Mende, Katrin Galloway, Renee L. Hospenthal, Duane R. TI ANTIMICROBIAL SUSCEPTIBILITIES OF CLINICAL HUMAN ISOLATES OF LEPTOSPIRA FROM EGYPT SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Murray, Clinton K.; Beckius, Miriam L.; Hospenthal, Duane R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Pimentel, Guillermo; Rhman, Bassern Abdel] US NAMRU3, Cairo, Egypt. [Parker, Tina] NIH, Bethesda, MD 20892 USA. [Samir, Ahmed] Cairo Univ, Cairo, Egypt. [Mende, Katrin] Infect Dis Clin Res Program, Ft Sam Houston, TX USA. [Galloway, Renee L.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 266 BP 78 EP 78 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600267 ER PT J AU Stewart, A Morrison, A Forshey, BM Wei-Mei, C Galvez, H Eza, D Montgomery, JM Bentzel, DE Kochel, T AF Stewart, Alison Morrison, Amy Forshey, Brett M. Wei-Mei, Ching Galvez, Hugo Eza, Dominique Montgomery, Joel M. Bentzel, David E. Kochel, Tadeusz TI EPIDEMIOLOGY OF RICKETTSIAL INFECTION IN IQUITOS, PERU SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Stewart, Alison] Univ Michigan, Ann Arbor, MI 48109 USA. [Morrison, Amy; Eza, Dominique] Univ Calif Davis, Davis, CA 95616 USA. [Forshey, Brett M.; Bentzel, David E.; Kochel, Tadeusz] USN, Med Res Ctr Detachment, Lima, Peru. [Wei-Mei, Ching] Naval Med Res Ctr, Bethesda, MD USA. [Galvez, Hugo] Inst Vet Invest Trop & Altura, Iquitos, Peru. [Montgomery, Joel M.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 272 BP 79 EP 80 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600273 ER PT J AU dos Santos, H Bandyopadhyay, K Bandea, R Peralta, RH Peralta, JM Ndubuisi, M Daniell, C DiMiceli, L Park, M da Silva, AJ AF dos Santos, Helena Bandyopadhyay, Kakali Bandea, Rebecca Peralta, Regina H. Peralta, Jose M. Ndubuisi, MacKevin Daniell, Cindy DiMiceli, Lauren Park, Mahin da Silva, Alexandre J. TI DEVELOPMENT OF 18S-BASED IDENTIFICATION OF ENTAMOEBA SPP. IN STOOL SAMPLES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [dos Santos, Helena; Peralta, Regina H.; Peralta, Jose M.] Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil. [Bandyopadhyay, Kakali; Bandea, Rebecca; da Silva, Alexandre J.] Ctr Dis Control & Prevent, Div Parasit Dis, NCZVED, Atlanta, GA USA. [Bandyopadhyay, Kakali; Bandea, Rebecca] Atlanta Res & Educ Fdn, Atlanta, GA USA. [Ndubuisi, MacKevin; Daniell, Cindy; DiMiceli, Lauren; Park, Mahin] Georgia Dept Hlth, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 279 BP 81 EP 82 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600280 ER PT J AU Ross, JM Winthrop, KL Choi, D Gilman, RH Ortega, Y Cabrera, L Xiao, LHH Cama, VA AF Ross, Jennifer M. Winthrop, Kevin L. Choi, Dongseok Gilman, Robert H. Ortega, Ynes Cabrera, Lilia Xiao, Lihua H. Cama, Vitaliano A. TI PARASITIC CO-INFECTION WITH GIARDIA INTESTINALIS AND CYCLOSPORA CAYETANENSIS AMONG CHILDREN IN PERU SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Ross, Jennifer M.; Winthrop, Kevin L.; Choi, Dongseok] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Gilman, Robert H.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Ortega, Ynes] Univ Georgia, Ctr Food Safety, Griffin, GA USA. [Cabrera, Lilia] Asociac Benef PRISMA, Lima, Peru. [Xiao, Lihua H.; Cama, Vitaliano A.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 278 BP 81 EP 81 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600279 ER PT J AU Cama, VA Nundy, S Cabrera, L Cama, R Gilman, RH Xiao, LH AF Cama, Vitaliano A. Nundy, Shantanu Cabrera, Lilia Cama, Rosa Gilman, Robert H. Xiao, Lihua TI USE OF PRINCIPAL COMPONENT ANALYSIS TO EVALUATE WEALTH AND ITS ASSOCIATIONS WITH ENTERIC PARASITIC INFECTIONS IN A LOW-INCOME COMMUNITY SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Cama, Vitaliano A.] CDC, Atlanta Res & Educ Fdn, Atlanta, GA 30333 USA. [Nundy, Shantanu; Gilman, Robert H.] Johns Hopkins Univ, Baltimore, MD USA. [Cabrera, Lilia; Cama, Rosa] AB Prisma, Lima, Peru. [Xiao, Lihua] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 282 BP 82 EP 83 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600283 ER PT J AU Johnston, SP Qvarnstrom, Y Arrowood, M Bishop, HS da Silva, AJ AF Johnston, Stephanie P. Qvarnstrom, Yvonne Arrowood, Michael Bishop, Henry S. da Silva, Alexandre J. TI EVALUATION OF STOOL FIXATIVES FOR MORPHOLOGIC AND MOLECULAR DIAGNOSIS OF CRYPTOSPORIDIOSIS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Johnston, Stephanie P.; Qvarnstrom, Yvonne; Arrowood, Michael; Bishop, Henry S.; da Silva, Alexandre J.] Ctr Dis Control & Prevent, Div Parasit Dis, NCZVED, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 287 BP 84 EP 84 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600288 ER PT J AU Butler, SE Muok, EM Montgomery, SP Mwinzi, PM Karanja, DM Secor, WE AF Butler, Sara E. Muok, Erick M. Montgomery, Susan P. Mwinzi, Pauline M. Karanja, Diana M. Secor, W. Evan TI MECHANISM OF ANEMIA IN SCHISTOSOMA MANSONI-INFECTED SCHOOL CHILDREN IN WESTERN KENYA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Butler, Sara E.; Montgomery, Susan P.; Secor, W. Evan] Ctr Dis Control & Prevent, Atlanta, GA USA. [Muok, Erick M.; Mwinzi, Pauline M.; Karanja, Diana M.] Kenya Govt Med Res Ctr, Kisumu, Kenya. RI Greenberg, Robert/D-1091-2009 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 297 BP 87 EP 87 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600298 ER PT J AU Mwinzi, PNM Mwanje, M Owaga, C Muok, E Laserson, K Kubaje, A Montgomery, S Secor, WE Muchiri, E Karanja, DMS AF Mwinzi, Pauline N. M. Mwanje, Mariam Owaga, Chrispin Muok, Erick Laserson, Kayla Kubaje, Adazu Montgomery, Susan Secor, W. Evan Muchiri, Erick Karanja, Diana M. S. TI COMMUNITY-DIRECTED INTERVENTION FOR SCHISTOSOMIASIS AND SOIL TRANSMITTED HELMINTHES IN WESTERN KENYA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Mwinzi, Pauline N. M.; Owaga, Chrispin; Muok, Erick; Karanja, Diana M. S.] Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Kisumu, Kenya. [Mwanje, Mariam; Muchiri, Erick] Kenya Minist Hlth, Div Vector Borne Dis, Nairobi, Kenya. [Laserson, Kayla; Kubaje, Adazu] KEMRI Ctr Dis Control & Prevent, Kenya Med Res Inst, Ctr Global Hlth Res, Kisumu, Kenya. [Montgomery, Susan; Secor, W. Evan] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 299 BP 87 EP 87 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600300 ER PT J AU Black, CL Mwinzi, PN Secor, WE Karanja, DM Colley, DG AF Black, Carla L. Mwinzi, Pauline N. Secor, W. Evan Karanja, Diana M. Colley, Daniel G. TI A PRINCIPAL COMPONENTS ANALYSIS OF IMMUNE PARAMETERS ASSOCIATED WITH RESISTANCE TO REINFECTION WITH SCHISTOSOMA MANSONI SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Black, Carla L.; Colley, Daniel G.] Univ Georgia, Athens, GA 30602 USA. [Mwinzi, Pauline N.; Karanja, Diana M.] Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Kisumu, Kenya. [Secor, W. Evan] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 302 BP 88 EP 88 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600303 ER PT J AU Logue, CH AF Logue, Christopher H. TI VIRULENCE VARIATION AMONG ISOLATES OF WESTERN EQUINE ENCEPHALITIS VIRUS IN AN OUTBRED MOUSE MODEL SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Logue, Christopher H.] Ctr Dis Control & Prevent, Ft Collins, CO USA. [Logue, Christopher H.] Colorado State Univ, Ft Collins, CO 80523 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 311 BP 91 EP 91 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600311 ER PT J AU Salmon-Mulanovich, G Albujar, C Guevara, C Vasquez, A Laguna, A Salazar, M Zamalloa, H Caceres, M Kochel, T Contreras, C Jackson, FR Rupprecht, CE Montgomery, JM AF Salmon-Mulanovich, Gabriela Albujar, Christian Guevara, Carolina Vasquez, Alicia Laguna, Alberto Salazar, Milagros Zamalloa, Hernan Caceres, Marcia Kochel, Tadeusz Contreras, Carolos Jackson, Felix R. Rupprecht, Charles E. Montgomery, Joel M. TI RABIES IN BATS IN TWO COMMUNITIES IN PERU AFTER AN OUTBREAK IN 2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Salmon-Mulanovich, Gabriela; Albujar, Christian; Guevara, Carolina; Laguna, Alberto; Zamalloa, Hernan; Kochel, Tadeusz; Montgomery, Joel M.] Naval Med Res Ctr Detachment, Lima, Peru. [Vasquez, Alicia] Univ Nacl Mayor San Marcos, Museo Hist Nat, Lima 14, Peru. [Salazar, Milagros] Univ Texas Med Branch, Galveston, TX USA. [Caceres, Marcia; Contreras, Carolos] Direcc Salud, Madre De Dios, Peru. [Jackson, Felix R.; Rupprecht, Charles E.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 312 BP 91 EP 91 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600312 ER PT J AU Rahman, MA Hossain, MJ Sultana, S Sazzad, S Homaira, N Afroze, S Rahman, M Gurley, E Luby, SR AF Rahman, Muhammad Aziz Hossain, M. Jahangir Sultana, Sharmin Sazzad, Shahed Homaira, Nusrat Afroze, Sayma Rahman, Mahmudur Gurley, Emily Luby, Stephen R. TI TRANSMISSION OF NIPAH BY DATE PALM SAP, BANGLADESH 2008 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Rahman, Muhammad Aziz; Hossain, M. Jahangir; Sazzad, Shahed; Homaira, Nusrat; Gurley, Emily; Luby, Stephen R.] Int Ctr Diarrhoeal Dis Res, Dhaka, Bangladesh. [Rahman, Muhammad Aziz; Sultana, Sharmin; Homaira, Nusrat; Afroze, Sayma; Rahman, Mahmudur] IEDCR, Dhaka, Bangladesh. [Luby, Stephen R.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RI Gurley, Emily/B-7903-2010; OI Gurley, Emily/0000-0002-8648-9403; Rahman, Muhammad Aziz/0000-0003-1665-7966 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 319 BP 93 EP 93 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600319 ER PT J AU Black, CL Steinauer, ML Mwinzi, PN Secor, WE Karanja, DM Colley, DG AF Black, Carla L. Steinauer, Michelle L. Mwinzi, Pauline N. Secor, W. Evan Karanja, Diana M. Colley, Daniel G. TI IMPACT OF INTENSE, LONGITUDINAL RETREATMENT WITH PRAZIQUANTEL ON CURE RATES OF SCHISTOSOMIASIS MANSONI IN A COHORT OF OCCUPATIONALLY EXPOSED ADULTS IN WESTERN KENYA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Black, Carla L.; Colley, Daniel G.] Univ Georgia, Athens, GA 30602 USA. [Steinauer, Michelle L.] Univ New Mexico, Albuquerque, NM 87131 USA. [Mwinzi, Pauline N.; Karanja, Diana M.] Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Kisumu, Kenya. [Secor, W. Evan] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 330 BP 97 EP 97 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600330 ER PT J AU Montgomery, SR Muok, EM Mwinzi, PN Williamson, JM Secor, WE Karanja, DM AF Montgomery, Susan R. Muok, Erick M. Mwinzi, Pauline N. Williamson, John M. Secor, W. Evan Karanja, Diana M. TI ESTIMATION OF ATTRIBUTABLE RISK OF ANEMIA DUE TO SCHISTOSOMIASIS IN WESTERN KENYA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Montgomery, Susan R.; Williamson, John M.; Secor, W. Evan] Ctr Dis Control & Prevent, Atlanta, GA USA. [Muok, Erick M.; Mwinzi, Pauline N.; Karanja, Diana M.] Kenya Govt Med Res Ctr, Kisumu, Kenya. NR 0 TC 0 Z9 0 U1 2 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 332 BP 97 EP 98 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600332 ER PT J AU King, JD Richards, F Eigege, A Jip, N Umaru, J Deming, M McFarland, D Miri, E Emerson, PM AF King, Jonathan D. Richards, Frank Eigege, Abel Jip, Nimzing Umaru, John Deming, Michael McFarland, Deborah Miri, Emmanuel Emerson, Paul M. TI INTEGRATING PROTOCOLS FOR MAPPING TRACHOMA AND URINARY SCHISTOSOMIASIS. CAN SURVEYS BE DONE SIMULTANEOUSLY? SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [King, Jonathan D.; Richards, Frank; Emerson, Paul M.] Emory Univ, Carter Ctr, Atlanta, GA 30322 USA. [Eigege, Abel; Jip, Nimzing; Umaru, John; Miri, Emmanuel] Carter Ctr, Jos, Nigeria. [Deming, Michael] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 335 BP 98 EP 99 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600335 ER PT J AU Verani, JR Abudho, B Montgomery, SR Mwinzi, PM Shane, HL Butler, SE Karanja, DM Secor, WE AF Verani, Jennifer R. Abudho, Bernard Montgomery, Susan R. Mwinzi, Pauline M. Shane, Hillary L. Butler, Sara E. Karanja, Diana M. Secor, William E. TI SCHISTOSOMIASIS AMONG YOUNG CHILDREN IN WESTERN KENYA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Verani, Jennifer R.; Montgomery, Susan R.; Shane, Hillary L.; Butler, Sara E.; Secor, William E.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Abudho, Bernard; Mwinzi, Pauline M.; Karanja, Diana M.] Kenya Govt Med Res Ctr, Kisumu, Kenya. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 333 BP 98 EP 98 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600333 ER PT J AU Jain, V Biswas, S Dash, AP Lucchi, N Singh, N AF Jain, Vidhan Biswas, Sukla Dash, A. P. Lucchi, Naomi Singh, Neeru TI CYTOKINE PROFILE IN VARIOUS SEVERE FORMS OF FALCIPARUM MALARIA IN CENTRAL INDIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Jain, Vidhan] ICMR, Natl Inst Malaria Res FS, Jabalpur, India. [Biswas, Sukla; Dash, A. P.] ICMR, Natl Inst Malaria Res, New Delhi, India. [Lucchi, Naomi] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis, Atlanta, GA USA. [Singh, Neeru] ICMR, Reg Med Res Ctr Tribals, Jabalpur, India. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 341 BP 100 EP 101 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600341 ER PT J AU McCollum, AM Udhayakumar, V Escalante, AA AF McCollum, Andrea M. Udhayakumar, Venkatachalam Escalante, Ananias A. TI GENETIC HITCHHIKING, SELECTIVE SWEEPS, AND MULTIPLE ORIGINS OF DRUG RESISTANT PLASMODIUM FALCIPARUM IN THREE DISTINCT POPULATIONS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [McCollum, Andrea M.; Udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Atlanta, GA USA. [Escalante, Ananias A.] Arizona State Univ, Tempe, AZ USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 343 BP 101 EP 101 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600343 ER PT J AU Sridaran, S Syphard, LM Barnwell, JW Udhayakumar, V AF Sridaran, Sankar Syphard, Luke M. Barnwell, John W. Udhayakumar, Venkatachalam TI META-ANALYSIS OF MOLECULAR SURVEILLANCE STUDIES EXAMINING SULPHADOXINE-PYRIMETHAMINE (SP) RESISTANCE MARKERS IN AFRICAN PLASMODIUM FALCIPARUM POPULATIONS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Sridaran, Sankar; Syphard, Luke M.; Barnwell, John W.; Udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 347 BP 102 EP 102 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600347 ER PT J AU Gatlin, MR Black, CL Mwinzi, PN Secor, WE Karanja, DM Colley, DG AF Gatlin, Michael R. Black, Carla L. Mwinzi, Pauline N. Secor, W. Evan Karanja, Diana M. Colley, Daniel G. TI ASSOCIATION OF THE GENE POLYMORPHISMS IFN-gamma+874 AND IL-13-1055 WITH PATTERNS OF REINFECTION WITH SCHISTOSOMA MANSONI SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Gatlin, Michael R.; Black, Carla L.; Colley, Daniel G.] Univ Georgia, Athens, GA 30602 USA. [Mwinzi, Pauline N.; Karanja, Diana M.] Kenya Govt Med Res Ctr, Kisumu, Kenya. [Secor, W. Evan] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 358 BP 105 EP 105 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600358 ER PT J AU Mwinzi, PN Ganley-Leal, LM Black, CL Secor, WE Karanja, DM Colley, DG AF Mwinzi, Pauline N. Ganley-Leal, Lisa M. Black, Carla L. Secor, W. Evan Karanja, Diana M. Colley, Daniel G. TI CIRCULATING CD23+B CELL SUBSET LEVELS IN ADULTS WITH SCHISTOSOMA MANSONI INFECTIONS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Mwinzi, Pauline N.; Karanja, Diana M.] Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Kisumu, Kenya. [Ganley-Leal, Lisa M.] Boston Univ, Sch Med, Boston Med Ctr, Boston, MA 02118 USA. [Black, Carla L.; Colley, Daniel G.] Univ Georgia, Athens, GA 30602 USA. [Secor, W. Evan] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 362 BP 106 EP 106 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600362 ER PT J AU Olson, CK Blum, LS Naik, K Oria, P Mathingau, A Odidi, B Feikin, D Laserson, K Wamae, AW Breiman, RF Ram, PK AF Olson, Christine K. Blum, Lauren S. Naik, Kinnery Oria, Prisca Mathingau, Alice Odidi, Beatrice Feikin, Daniel Laserson, Kayla Wamae, Anna W. Breiman, Robert F. Ram, Pavani K. TI FACTORS ASSOCIATED WITH ORAL REHYDRATION THERAPY UTILIZATION FOR CHILDHOOD DIARRHEA MANAGEMENT AMONG PRIMARY HOUSEHOLD CAREGIVERS - ASEMBO, KENYA 2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Olson, Christine K.; Naik, Kinnery] Ctr Dis Control & Prevent, Atlanta, GA USA. [Blum, Lauren S.; Oria, Prisca; Mathingau, Alice; Odidi, Beatrice; Feikin, Daniel; Breiman, Robert F.] Kenya Govt Med Res Ctr, Ctr Dis Control & Prevent, Int Emerging Infect Program, Kisumu, Kenya. [Laserson, Kayla] Ctr Global Hlth Res, Kenya Med Res Inst, Ctr Dis Control & Prevent, Kisumu, Kenya. [Wamae, Anna W.] Republ Kenya Minist Hlth, Nairobi, Kenya. [Ram, Pavani K.] SUNY Buffalo, Buffalo, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 SU S MA 368 BP 108 EP 108 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600368 ER PT J AU Trivedi, KK Omore, R Blanton, E Adazu, K Vulule, J Laserson, K Crump, JA Levine, MM Kotloff, K van Eijk, A Mintz, ED O'Reilly, CE Breiman, RF AF Trivedi, Kavita K. Omore, Richard Blanton, Elizabeth Adazu, Kubaje Vulule, John Laserson, Kayla Crump, John A. Levine, Myron M. Kotloff, Karen van Eijk, Annemieke Mintz, Eric D. O'Reilly, Ciara E. Breiman, Robert F. TI MANAGEMENT OF DIARRHEAL ILLNESS IN YOUNG CHILDREN OF RURAL WESTERN KENYA - FINDINGS FROM A HEALTH UTILIZATION AND ATTITUDES SURVEY, 2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Trivedi, Kavita K.; Blanton, Elizabeth; Vulule, John; Mintz, Eric D.; O'Reilly, Ciara E.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Omore, Richard; Adazu, Kubaje; Laserson, Kayla] Ctr Dis Control & Prevent, Kenya Med Res Inst, Kisumu, Kenya. [Vulule, John] Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Kisumu, Kenya. [Levine, Myron M.; Kotloff, Karen; van Eijk, Annemieke] Univ Maryland, Sch Med, Ctr Vaccine Dev, Baltimore, MD 21201 USA. [Breiman, Robert F.] Ctr Dis Control & Prevent, Kenya Med Res Inst, Nairobi, Kenya. RI kotloff, karen/E-7768-2012 OI kotloff, karen/0000-0003-1808-6431 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 369 BP 108 EP 109 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600369 ER PT J AU Adazu, K Hamel, M Feikin, D Ofware, P Obor, D Ogwang, S Orimba, V Vulule, J Slutsker, L Laserson, K AF Adazu, Kubaje Hamel, Mary Feikin, Daniel Ofware, Peter Obor, David Ogwang, Sheila Orimba, Vincent Vulule, John Slutsker, Laurence Laserson, Kayla TI MARKED DECLINE IN CHILDHOOD MORTALITY IN THE WESTERN KENYA DSS: EVIDENCE FROM LONGITUDINAL DATA, 2003-2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Adazu, Kubaje; Hamel, Mary; Feikin, Daniel; Ofware, Peter; Obor, David; Ogwang, Sheila; Orimba, Vincent; Laserson, Kayla] KEMRI CDC Field Res Stn, Kisumu, Kenya. [Vulule, John] KEMRI CGHR, Kisumu, Kenya. [Slutsker, Laurence] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 372 BP 109 EP 110 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600372 ER PT J AU Naik, K Olson, CK Boore, AL Blum, LS Mathingau, A Odidi, B Laserson, KF Feikin, DR Wamae, AW Breiman, RF Ram, AK AF Naik, Kinnery Olson, Christine K. Boore, Amy L. Blum, Lauren S. Mathingau, Alice Odidi, Beatrice Laserson, Kayla F. Feikin, Daniel R. Wamae, Annah W. Breiman, Robert F. Ram, Avani Kalluri TI FACTORS ASSOCIATED WITH RECOMMENDATION OF ORAL REHYDRATION THERAPY FOR DIARRHEA TREATMENT AMONG HEALTH WORKERS IN KENYA, 2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Naik, Kinnery; Olson, Christine K.; Boore, Amy L.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Blum, Lauren S.; Mathingau, Alice; Odidi, Beatrice; Feikin, Daniel R.; Breiman, Robert F.] CDC KEMRI, Int Emerging Infect Program, Kisumu, Kenya. [Laserson, Kayla F.] Ctr Global Hlth Res, CDC KEMRI, Kisumu, Kenya. [Wamae, Annah W.] Republ Kenya Minist Hlth, Nairobi, Kenya. [Ram, Avani Kalluri] SUNY Buffalo, Buffalo, NY 14260 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 370 BP 109 EP 109 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600370 ER PT J AU Lucchi, NW Mixon, T Udhayakumar, V AF Lucchi, Naomi W. Mixon, Tonya Udhayakumar, Venkatachalam TI EVALUATION OF THREE DIFFERENT PCR BASED ASSAYS FOR MALARIA DIAGNOSIS AND SPECIATION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Lucchi, Naomi W.; Mixon, Tonya; Udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Chamblee, GA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 392 BP 116 EP 116 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600392 ER PT J AU Griffing, SM Syphard, L Sridaran, S McCollum, A Villegas, L Escalante, AA Barnwell, J Udhayakumar, V AF Griffing, Sean M. Syphard, Luke Sridaran, Sankar McCollum, Andrea Villegas, Leopoldo Escalante, Ananias A. Barnwell, John Udhayakumar, Venkatachalam TI FIXATION OF MUTATIONS AND A SINGLE ORIGIN OF PFCRT AND PFMDR1 HAPLOTYPES IN PLASMODIUM FALCIPARUM FROM VENEZUELA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Griffing, Sean M.] Emory Univ, Ctr Dis Control & Prevent, Atlanta Res & Educ Fdn, Atlanta, GA 30322 USA. [Syphard, Luke] Ctr Dis Control & Prevent, Chamblee, GA USA. [Villegas, Leopoldo] Asociac Vicil Impacto Social, Tumeremo, Venezuela. [Escalante, Ananias A.] Arizona State Univ, Tempe, AZ USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 408 BP 121 EP 121 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600408 ER PT J AU Kosoy, MY Bai, Y Lerdthusnee, K Richardson, JH Boonmar, S Peruski, LF Suttirattana, S Maloney, SA AF Kosoy, Michael Y. Bai, Ying Lerdthusnee, Kriangkrai Richardson, Jason H. Boonmar, Sumalee Peruski, Leonard F. Suttirattana, Saithip Maloney, Susan A. TI PHYLOGENETIC RELATIONS BETWEEN BARTONELLA STRAINS IDENTIFIED IN ANIMALS AND HUMANS FROM THAILAND SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Kosoy, Michael Y.; Bai, Ying] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO USA. [Lerdthusnee, Kriangkrai; Richardson, Jason H.] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Boonmar, Sumalee] Kasetsart Univ, Fac Med Vet, Bangkok, Thailand. [Peruski, Leonard F.; Suttirattana, Saithip; Maloney, Susan A.] Thailand MOPH US CDC Collaborat, Int Emerging Infect Program, Nonthaburi, Thailand. RI Richardson, Jason/A-9441-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 416 BP 123 EP 123 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600416 ER PT J AU Lydy, SL Lascano, M Garcia, J Dasch, GA Grijalva, MJ AF Lydy, Shari L. Lascano, Mauricio Garcia, Josselyn Dasch, Gregory A. Grijalva, Mario J. TI SEROPREVALENCE AND EPIDEMIOLOGY OF BARTONELLA BACILLIFORMIS INFECTION IN ECUADOR SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Lydy, Shari L.; Dasch, Gregory A.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Lascano, Mauricio; Grijalva, Mario J.] Ohio Univ, Athens, OH 45701 USA. [Garcia, Josselyn] Catholic Univ Ecuador, Quito, Ecuador. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 417 BP 123 EP 123 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600417 ER PT J AU Weber, IB Staples, JE Owor, N Borchert, JN Apangu, T Babi, N Griffith, KS Enscore, RE Mbidde, E Mead, PS AF Weber, Ingrid B. Staples, J. Erin Owor, Nicholas Borchert, Jeff N. Apangu, Titus Babi, Nackson Griffith, Kevin S. Enscore, Russell E. Mbidde, Edward Mead, Paul S. TI PLAGUE IN THE WEST NILE REGION, UGANDA, 1999-2008 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Weber, Ingrid B.; Staples, J. Erin; Borchert, Jeff N.; Griffith, Kevin S.; Enscore, Russell E.; Mead, Paul S.] Ctr Dis Control & Prevent, Ft Collins, CO USA. [Owor, Nicholas; Apangu, Titus; Babi, Nackson; Mbidde, Edward] Uganda Virus Res Inst, Entebbe, Uganda. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 419 BP 124 EP 124 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600419 ER PT J AU Freitas, GD Nobrega, A Romano, A Pontes, M Leite, L Costa, E Sobel, J AF Freitas, Gisele Dias Nobrega, Aglaer Romano, Alessandro Pontes, Maria Leite, Liliane Costa, Elenild Sobel, Jeremy TI CLINICAL CHARACTERISTICS OF THREES PATIENTS WITH ACUTE, ORALLY TRANSMITTED CHAGAS DISEASE: THE PROMINENCE OF GASTROINTESTINAL SYMPTOMS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Freitas, Gisele Dias; Nobrega, Aglaer; Romano, Alessandro] Minist Hlth, Brasilia, DF, Brazil. [Sobel, Jeremy] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 423 BP 125 EP 125 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600423 ER PT J AU Weinkopff, TS Crosby, SD Heinz, M Mladonicky, J Lammie, P Williams, S AF Weinkopff, Tiffany S. Crosby, Seth D. Heinz, Mike Mladonicky, Janice Lammie, Patrick Williams, Steve TI MOLECULAR ANALYSIS OF THE EFFECT OF DIETHYLCARBAMAZINE ON BRUGIA MALAYI MICROFILARIAE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Weinkopff, Tiffany S.] Univ Georgia, Dept Cellular Biol, Athens, GA 30602 USA. [Crosby, Seth D.; Heinz, Mike] Washington Univ, Sch Med, Dept Genet, Genome Sequencing Ctr, St Louis, MO 63110 USA. [Mladonicky, Janice; Lammie, Patrick] Ctr Dis Control & Prevent, Atlanta, GA USA. [Williams, Steve] Smith Coll, Dept Biol Sci, Clark Sci Ctr, Northampton, MA 01063 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 432 BP 128 EP 128 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600432 ER PT J AU Noh, J McAuliffe, I Lee, YM Handali, S Silva-Ibanez, M Hancock, K Garcia, HH Gonzalez, AE Gilman, RH Wilkins, P Tsang, VCW AF Noh, John McAuliffe, Isabel Lee, Yeuk-Mui Handali, Sukwan Silva-Ibanez, Maria Hancock, Kathy Garcia, Hector H. Gonzalez, Armando E. Gilman, Robert H. Wilkins, Patricia Tsang, Victor C. W. TI ASSAY DEVELOPMENT AND OPTIMIZATION FOR CYSTICERCOSIS USING RECOMBINANT AND SYNTHETIC DIAGNOSTIC PROTEINS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Noh, John; McAuliffe, Isabel; Lee, Yeuk-Mui; Hancock, Kathy; Wilkins, Patricia] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA. [Handali, Sukwan] Atlanta Res & Educ Fdn, Atlanta, GA USA. [Silva-Ibanez, Maria; Tsang, Victor C. W.] Georgia State Univ, Dept Biol, Atlanta, GA USA. [Garcia, Hector H.; Gonzalez, Armando E.; Gilman, Robert H.] Cysticercosis Working Grp, Lima, Peru. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 440 BP 130 EP 130 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600439 ER PT J AU Salim, L Ang, A Handali, S Tsang, VCW AF Salim, Lidwina Ang, Agnes Handali, Sukwan Tsang, Victor C. W. CA Cysticercosis Working Grp Papua TI CYSTICERCOSIS AND TAENIASIS IN PAPUA, INDONESIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Salim, Lidwina; Ang, Agnes; Handali, Sukwan; Tsang, Victor C. W.; Cysticercosis Working Grp Papua] Ctr Dis Control & Prevent, Chamblee, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 439 BP 130 EP 130 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600438 ER PT J AU Mathison, BA da Silva, AJ Johnston, SF Bishop, HS Long, E Eberhard, M AF Mathison, Blaine A. da Silva, Alexandre J. Johnston, Stephanie F. Bishop, Henry S. Long, Earl Eberhard, Mark TI USEFULNESS OF TELEDIAGNOSIS IN THE IDENTIFICATION OF TISSUE PARASITES: AN EVALUATION BASED ON TWO YEARS (FROM 2006 TO 2008) OF TELEDIAGNOSIS SUBMISSIONS TO THE CDC DPDX PROJECT SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Mathison, Blaine A.; da Silva, Alexandre J.; Johnston, Stephanie F.; Bishop, Henry S.; Long, Earl; Eberhard, Mark] Ctr Dis Control & Prevent, Div Parasit Dis, NCZVED, Atlanta, GA USA. [Mathison, Blaine A.] Atlanta Res & Educ Fdn, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 456 BP 135 EP 135 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600455 ER PT J AU Han, P Yanni, E Davis, XH Pollard, W Maran, N AF Han, Pauline Yanni, Emad Davis, Xiaohong Pollard, William Maran, Nina TI TRAVEL HEALTH ADVICE-SEEKING BEHAVIOR OF US TRAVELERS TO YELLOW FEVER- AND JAPANESE ENCEPHALITIS-ENDEMIC COUNTRIES: FINDINGS FROM THE 2007 HEALTHSTYLES SURVEY SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Han, Pauline] Ctr Dis Control & Prevent, Oak Ridge Inst Sci & Educ, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 461 BP 136 EP 136 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600460 ER PT J AU Tongren, JE Deyrup, L Yartel, A Beckett, G AF Tongren, Jon Eric Deyrup, Leif Yartel, Anthony Beckett, Geoff TI IMPLICATIONS OF A CHANGE IN THE CASE DEFINITION OF LYME DISEASE SURVEILLANCE - MAINE, 2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Tongren, Jon Eric] Ctr Dis Control & Prevent, Atlanta, GA USA. [Deyrup, Leif; Yartel, Anthony; Beckett, Geoff] Maine Ctr Dis Control & Prevent, Augusta, ME USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 477 BP 141 EP 141 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600476 ER PT J AU Sturgeon, MM Beeler, E Krueger, L Hu, R Vangordon, G Rood, M Spano, R Bermudez, S Dasch, GA Eremeeva, ME AF Sturgeon, Michele M. Beeler, Emily Krueger, Laura Hu, Renjie Vangordon, Gail Rood, Michael Spano, Robyn Bermudez, Sergio Dasch, Gregory A. Eremeeva, Marina E. TI DETECTION OF SPOTTED FEVER GROUP RICKETTSIA IN IXODID TICKS COLLECTED IN LOS ANGELES COUNTY, CALIFORNIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Sturgeon, Michele M.; Bermudez, Sergio; Dasch, Gregory A.; Eremeeva, Marina E.] Ctr Dis Control, Atlanta, GA 30333 USA. [Beeler, Emily] Los Angeles Dept Publ Hlth, Vet Publ Hlth & Rabies Control Program, Downey, CA USA. [Krueger, Laura] Orange Cty Vector Control Dist, Garden Grove, CA USA. [Hu, Renjie] Calif Dept Publ Hlth, Vector Borne Dis Sect, Ontario, CA USA. [Vangordon, Gail; Rood, Michael; Spano, Robyn] Los Angeles Cty Dept Publ Hlth, Vector Management Program, Baldwin Pk, CA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 480 BP 142 EP 142 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600479 ER PT J AU Erb, SM Butrapet, S Phillips, A Childers, T Roehrig, J Huang, C Blair, C AF Erb, Steven M. Butrapet, Siritorn Phillips, Aaron Childers, Thomas Roehrig, John Huang, Claire Blair, Carol TI INFECTION OF AEDES AEGYPTI BY DENGUE VIRUS TYPE 2 STRAIN 16681 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Erb, Steven M.; Phillips, Aaron; Blair, Carol] Colorado State Univ, Ft Collins, CO 80523 USA. [Butrapet, Siritorn; Childers, Thomas; Roehrig, John; Huang, Claire] Ctr Dis Control & Prevent, Ft Collins, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 489 BP 144 EP 144 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600488 ER PT J AU Livengood, JA Kinney, RM Huang, CY Silengo, SJ Wiggan, O Luy, BE Moss, KJ Kalanidhi, AP Osorio, J Stinchcomb, DT AF Livengood, Jill A. Kinney, Richard M. Huang, Claire Y. Silengo, Shawn J. Wiggan, O'Neil Luy, Betty E. Moss, Kelley J. Kalanidhi, A. P. Osorio, Jorge Stinchcomb, Dan T. TI CHARACTERIZATION AND GROWTH OF A DEN-2 PDK-53-BASED CHIMERIC TETRAVALENT VACCINE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Livengood, Jill A.; Kinney, Richard M.; Silengo, Shawn J.; Wiggan, O'Neil; Stinchcomb, Dan T.] Inviragen, Ft Collins, CO USA. [Huang, Claire Y.; Luy, Betty E.; Moss, Kelley J.] Ctr Dis Control & Prevent, Ft Collins, CO USA. [Kalanidhi, A. P.] Shantha Biotech, Hyderabad, Andhra Pradesh, India. [Osorio, Jorge] Univ Wisconsin, Madison, WI USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 493 BP 146 EP 146 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600492 ER PT J AU Bessoff, K McElroy, KL Colon, C Amador, M Barrera, R Munoz-Jordan, J Sun, W Hunsperger, E AF Bessoff, Kovi McElroy, Kate L. Colon, Candimar Amador, Manuel Barrera, Roberto Munoz-Jordan, Jorge Sun, Wellington Hunsperger, Elizabeth TI GENETIC AND BIOLOGICAL CHARACTERIZATION OF THE FIRST CARIBBEAN WEST NILE VIRUS ISOLATES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Bessoff, Kovi; McElroy, Kate L.; Colon, Candimar; Amador, Manuel; Barrera, Roberto; Munoz-Jordan, Jorge; Sun, Wellington; Hunsperger, Elizabeth] Ctr Dis Control & Prevent, San Juan, PR USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 502 BP 148 EP 148 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600501 ER PT J AU Johnson, AJ Bowen, R Stark, L Kosoy, O Powers, A Panella, N Nemeth, N AF Johnson, Alison J. Bowen, Richard Stark, Lillian Kosoy, Olga Powers, Ann Panella, Nicholas Nemeth, Nicole TI BIOTINYLATION OF ANTIBODIES IN SERUM SAMPLES ALLEVIATES THE NEED FOR SPECIES-SPECIFIC DETECTION CONJUGATES WHEN ASSAYED FOR IN A MICROSPHERE-BASED SYSTEM SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Johnson, Alison J.; Kosoy, Olga; Powers, Ann; Panella, Nicholas] Ctr Dis Control & Prevent, Ft Collins, CO USA. [Bowen, Richard] Colorado State Univ, Coll Vet Med, Ft Collins, CO 80523 USA. [Stark, Lillian] Florida Dept Hlth, Tampa, FL USA. [Nemeth, Nicole] Natl Wildlife Res Ctr, USDA APHIS WS, Tampa, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 500 BP 148 EP 148 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600499 ER PT J AU Beck, ET Luy, B Huang, CYH AF Beck, Eric T. Luy, Betty Huang, Claire Y. H. TI CREATION OF A CHIMERIC WEST NILE VIRUS CONTAINING DENGUE-2 PRE-MEMBRANE AND ENVELOPE GENES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Beck, Eric T.; Luy, Betty; Huang, Claire Y. H.] Ctr Dis Control & Prevent, Ft Collins, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 507 BP 150 EP 150 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600506 ER PT J AU Huang, CY Kinney, RM Luy, BE Jones, K Marlenee, N Stinchcomb, DT Bowen, R AF Huang, Claire Y. Kinney, Richard M. Luy, Betty E. Jones, Kristin Marlenee, Nicole Stinchcomb, Dan T. Bowen, Richard TI LIVE ATTENUATED WEST NILE VACCINE BASED ON DEN-2 PDK-53 VECTOR PROTECTS HAMSTERS FROM WILD-TYPE WEST NILE VIRUS CHALLENGE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Huang, Claire Y.; Luy, Betty E.] Ctr Dis Control & Prevent, Ft Collins, CO USA. [Kinney, Richard M.; Stinchcomb, Dan T.] Inviragen, Ft Collins, CO USA. [Jones, Kristin; Marlenee, Nicole; Bowen, Richard] Colorado State Univ, Ft Collins, CO 80523 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 511 BP 151 EP 151 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600510 ER PT J AU Laven, JJ Delorey, MJ Kosoy, OL Panella, AJ Lanciotti, RS Johnson, AJ AF Laven, Janeen J. Delorey, Mark J. Kosoy, Olga L. Panella, Amanda J. Lanciotti, Robert S. Johnson, Alison J. TI DUPLEX MICROSPHERE-BASED ASSAY FOR THE DETECTION OF IGG ANTIBODIES TO WEST NILE VIRUS AND ST. LOUIS ENCEPHALITIS VIRUS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Laven, Janeen J.; Delorey, Mark J.; Kosoy, Olga L.; Panella, Amanda J.; Lanciotti, Robert S.; Johnson, Alison J.] Ctr Dis Control & Prevent, Ft Collins, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 512 BP 151 EP 151 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600511 ER PT J AU McAuliffe, I Handali, S Lee, YM Noh, J Gleim, E Wilkins, P AF McAuliffe, I. Handali, S. Lee, Y. M. Noh, J. Gleim, E. Wilkins, P. TI OPTIMIZATION OF AN ELISA ASSAY FOR THE DETECTION OF STRONGYLOIDES STERCORALIS INFECTION IN HUMANS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [McAuliffe, I.; Lee, Y. M.; Noh, J.; Wilkins, P.] Ctr Dis Control & Prevent, Coordinating Ctr Infect Dis, Natl Ctr Zoonot Vectorborne & Enter Dis, Parasit Dis Branch, Atlanta, GA USA. [Handali, S.; Gleim, E.] Atlanta Res & Educ Fdn, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 532 BP 157 EP 157 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600531 ER PT J AU Casandra, DR Umezawa, ES Todd, CW AF Casandra, Debora R. Umezawa, Eufrosina S. Todd, Charles W. TI EVALUATION OF THE IMMUNOBLOT WITH TESA FROM THREE DIFFERENT TRYPANOSOMA CRUZI STRAINS FOR THE SEROLOGICAL DIAGNOSIS OF CHAGAS DISEASE IN THE USA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Casandra, Debora R.; Todd, Charles W.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Umezawa, Eufrosina S.] Inst Med Trop Sao Paulo, Sao Paulo, Brazil. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 535 BP 158 EP 158 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600534 ER PT J AU Bandyopadhyay, K de Almeida, M Steurer, F Koru, O Herwald, BL da Silva, AJ AF Bandyopadhyay, Kakali de Almeida, Marcos Steurer, Francis Koru, Ozgur Herwald, Barbara L. da Silva, Alexandre J. TI A MULTIPLEX APPROACH FOR SIMULTANEOUS IDENTIFICATION OF SIX DISTINCT LEISHMANIA SPP SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Bandyopadhyay, Kakali; de Almeida, Marcos; Steurer, Francis; Koru, Ozgur; Herwald, Barbara L.; da Silva, Alexandre J.] NCZVED, Div Parasit Dis, Ctr Dis Control & Prevent, Atlanta, GA USA. [Bandyopadhyay, Kakali; de Almeida, Marcos; Koru, Ozgur] Atlanta Res & Educ Fdn, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 541 BP 159 EP 159 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600540 ER PT J AU Vinayak, S Rathore, D Kariuki, S Slutsker, L Shi, YP Villegas, L Escalante, A Udhayakumar, V AF Vinayak, Sumiti Rathore, Dharmendar Kariuki, Simon Slutsker, Laurence Shi, Ya Ping Villegas, Leopoldo Escalante, Ananias Udhayakumar, Venkatachalam TI PLASMODIUM FALCIPARUM HEME DETOXIFICATION PROTEIN (HDP) IS NOT LINKED TO CHLOROQUINE RESISTANCE GENOTYPE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Vinayak, Sumiti] Atlanta Res & Educ Fdn, Atlanta, GA USA. [Shi, Ya Ping; Udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis, Atlanta, GA USA. [Rathore, Dharmendar] Virginia Tech, Virginia Bioinformat Inst, Blacksburg, VA USA. [Kariuki, Simon] Kenya Govt Med Res Ctr, Ctr Victor Biol & Control Res, Kisumu, Kenya. [Villegas, Leopoldo] Asociac Civil Impacto Social, Tumeremo, Venezuela. [Escalante, Ananias] Arizona State Univ, Tempe, AZ USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 594 BP 175 EP 176 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600593 ER PT J AU Khatib, RA McMorrow, ML Kahigwa, E Elling, BF Bloland, PB Abdulla, SM Kachur, SP AF Khatib, Rashid A. McMorrow, Meredith L. Kahigwa, Elizeus Elling, Berty F. Bloland, Peter B. Abdulla, Salim M. Kachur, S. Patrick TI DYNAMICS OF MALARIA PARASITE AND ANAEMIA PREVALENCE IN RURAL TANZANIA: COMMUNITY CROSS-SECTIONAL SURVEYS, 2001-2006 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Khatib, Rashid A.; Kahigwa, Elizeus; Elling, Berty F.; Abdulla, Salim M.] Ifakara Hlth Res & Dev Ctr, Dar Es Salaam, Tanzania. [McMorrow, Meredith L.; Bloland, Peter B.; Kachur, S. Patrick] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 614 BP 182 EP 182 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600613 ER PT J AU Tijani, MK Grainger, M Odaibo, AA Anumudu, CI Awobode, HO Morenikeji, OA Omosun, Y Okafor, CM Ngoundou-Landji, J Asuzu, MC Asinobi, A Crabb, BS Anthony, HA Nwuba, RI AF Tijani, Muyideen K. Grainger, Munira Odaibo, Alex A. Anumudu, Chiaka I. Awobode, Henrieta O. Morenikeji, Olajumoke A. Omosun, Yusuf Okafor, Christian M. Ngoundou-Landji, Josiane Asuzu, Micheal C. Asinobi, Adanze Crabb, Brendan S. Anthony, Holder A. Nwuba, Roseangela I. TI SOME CHILDREN THAT LACK MEROZOITE SURFACE PROTEIN-1(MSP1) SECONDARY PROCESSING-INHIBITORY ANTIBODIES STILL POSSESS MSP1(19)-SPECIFIC ERYTHROCYTE INVASION-INHIBITORY ANTIBODIES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Tijani, Muyideen K.; Anumudu, Chiaka I.; Ngoundou-Landji, Josiane; Nwuba, Roseangela I.] Univ Ibadan, Dept Zool, Cellular Parasitol Programme, Ibadan, Nigeria. [Grainger, Munira; Anthony, Holder A.] Natl Inst Med Res, Parasitol Unit, London NW7 1AA, England. [Odaibo, Alex A.; Awobode, Henrieta O.; Morenikeji, Olajumoke A.] Univ Ibadan, Dept Zool, Parasitol Unit, Ibadan, Nigeria. [Omosun, Yusuf] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA. [Okafor, Christian M.] Seattle Biomed Res Inst, Seattle, WA 98109 USA. [Asuzu, Micheal C.] Univ Ibadan, Coll Med, Dept Community Med, Ibadan, Nigeria. [Asinobi, Adanze] Univ Coll Ibadan Hosp, Dept Peadiatr, Ibadan, Nigeria. [Crabb, Brendan S.] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic, Australia. RI Crabb, Brendan/F-5287-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 SU S MA 624 BP 185 EP 185 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600623 ER PT J AU Karunaweera, ND Ferreira, MU Barnwell, JW Munasinghe, A King, C Kawamoto, F Hartl, D Wirth, DF AF Karunaweera, Nadira D. Ferreira, Marcelo U. Barnwell, John W. Munasinghe, Anusha King, Christopher Kawamoto, Fumihiko Hartl, Daniel Wirth, Dyann F. TI EXTENSIVE GENETIC DIVERSITY IN THE HUMAN MALARIA PARASITE PLASMODIUM VIVAX SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Karunaweera, Nadira D.] Univ Colombo, Fac Med, Colmbo 8, Sri Lanka. [Ferreira, Marcelo U.] Univ Sao Paulo, Sao Paulo, Brazil. [Barnwell, John W.] Ctr Dis Control, Atlanta, GA 30333 USA. [Munasinghe, Anusha; Wirth, Dyann F.] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. [King, Christopher] Case Western Reserve Univ, Cleveland, OH 44106 USA. [Kawamoto, Fumihiko] Oita Univ, Oita 87011, Japan. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 634 BP 188 EP 188 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600633 ER PT J AU Ntumngia, FB McHenry, AM Barnwell, JW Cole-Tobian, J King, CL Adams, JH AF Ntumngia, Francis B. McHenry, Amy M. Barnwell, John W. Cole-Tobian, Jennifer King, Christopher L. Adams, John H. TI GENETIC VARIATION AMONG PLASMODIUM VIVAX PRIMATE ISOLATES AND THE IMPLICATION FOR VACCINE DEVELOPMENT SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Ntumngia, Francis B.; Adams, John H.] Univ S Florida, Global Hlth Infect Dis Res, Tampa, FL USA. [McHenry, Amy M.] Univ Notre Dame, Notre Dame, IN 46556 USA. [Barnwell, John W.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Cole-Tobian, Jennifer; King, Christopher L.] Case Western Reserve Univ, Sch Med, Ctr Global Hlth & Dis, Cleveland, OH USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 639 BP 189 EP 189 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601004 ER PT J AU Kent, RJ Aspen, S Williams, M Savage, H AF Kent, Rebekah J. Aspen, Stephen Williams, Martin Savage, Harry TI GENE EXPRESSION IN ADULT MOSQUITOES DURING POST-EMERGENCE DEVELOPMENT SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Kent, Rebekah J.; Aspen, Stephen; Williams, Martin; Savage, Harry] Ctr Dis Control & Prevent, Ft Collins, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 SU S MA 670 BP 198 EP 198 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601035 ER PT J AU Kent, RJ Aspen, S Williams, M Savage, H AF Kent, Rebekah J. Aspen, Stephen Williams, Martin Savage, Harry TI DEVELOPMENT OF A MULTIPLEXED PCR DIAGNOSTIC TO IDENTIFY COMMON MEMBERS OF THE SUBGENERA CULEX (CULEX) AND CULEX (PHENACOMYIA) IN GUATEMALA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Kent, Rebekah J.; Aspen, Stephen; Williams, Martin; Savage, Harry] Ctr Dis Control & Prevent, Ft Collins, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 SU S MA 671 BP 198 EP 198 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601036 ER PT J AU Mutuku, F Bayoh, NM Hightower, AW Vulule, JM Mueke, JM Gimnig, JE Walker, ED AF Mutuku, Francis Bayoh, Nabie M. Hightower, Allen W. Vulule, John M. Mueke, Jones M. Gimnig, John E. Walker, Edward D. TI HABITAT SEGREGATION AND CHARACTERIZATION OF ANOPHELES LARVAE IN LOWLAND WESTERN KENYA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Mutuku, Francis; Bayoh, Nabie M.; Vulule, John M.] Kenya Govt Med Res Ctr, Kisumu, Kenya. [Hightower, Allen W.] Kenya Govt Med Res Ctr, Ctr Dis Control & Prevent, Kisumu, Kenya. [Mueke, Jones M.] Kenyatta Univ, Nairobi, Kenya. [Gimnig, John E.] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA. [Walker, Edward D.] Michigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 SU S MA 689 BP 203 EP 203 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601054 ER PT J AU Mutuku, F Bayoh, NM Hightower, AW Vulule, JM Mueke, JM Gimnig, JE Walker, ED AF Mutuku, Francis Bayoh, Nabie M. Hightower, Allen W. Vulule, John M. Mueke, Jones M. Gimnig, John E. Walker, Edward D. TI LAND COVER ASSOCIATIONS OF IMMATURE ANOPHELES HABITATS IN A WESTERN KENYA LOWLAND ENDEMIC FOR MALARIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Mutuku, Francis; Vulule, John M.] Kenya Govt Med Res Ctr, Kisumu, Kenya. [Bayoh, Nabie M.; Hightower, Allen W.] Kenya Govt Med Res Ctr, Ctr Dis Control & Prevent, Kisumu, Kenya. [Mueke, Jones M.] Kenyatta Univ, Nairobi, Kenya. [Gimnig, John E.] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA. [Walker, Edward D.] Michigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 SU S MA 690 BP 203 EP 203 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601055 ER PT J AU Dedmon, RE Hanlon, CA Tumpey, A Briggs, DJ Costa, PJ AF Dedmon, Robert E. Hanlon, Cathleen A. Tumpey, Abbigail Briggs, Deborah J. Costa, Peter J. TI WORLD RABIES DAY A ONE HEALTH INITIATIVE TO ... MAKE RABIES HISTORY! SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Dedmon, Robert E.] Med Coll Wisconsin, Milwaukee, WI 53226 USA. [Hanlon, Cathleen A.] Kansas State Univ, Manhattan, KS 66506 USA. [Tumpey, Abbigail] Ctr Dis Control & Prevent, Atlanta, GA USA. [Costa, Peter J.] Global Alliance Rabies Control, Manhattan, KS USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 718 BP 212 EP 212 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601083 ER PT J AU Ghersi, BM Blazes, D Icochea, E Gonzalez, RI Kochel, T Tinoco, Y Sovero, M Lindstrom, S Shu, B Klimov, A Gonzalez, AE Montgomery, JM AF Ghersi, Bruno M. Blazes, David Icochea, Eliana Gonzalez, Rosa I. Kochel, Tadeusz Tinoco, Yeny Sovero, Merly Lindstrom, Stephen Shu, Bo Klimov, Alexander Gonzalez, Armando E. Montgomery, Joel M. TI AVIAN INFLUENZA IN WILD BIRDS FROM THE CENTRAL COAST OF PERU SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Ghersi, Bruno M.; Blazes, David; Kochel, Tadeusz; Sovero, Merly; Montgomery, Joel M.] Naval Med Res Ctr Detachment, Lima, Peru. [Icochea, Eliana; Gonzalez, Rosa I.; Gonzalez, Armando E.] Univ Nacl Mayor San Marcos, Lima 14, Peru. [Tinoco, Yeny] Johns Hopkins Univ, Sch Publ Hlth, Baltimore, MD 21218 USA. [Lindstrom, Stephen; Shu, Bo; Klimov, Alexander] Ctr Dis Control & Prevent, Atlanta, GA USA. RI Valle, Ruben/A-7512-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 719 BP 212 EP 212 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601084 ER PT J AU Manivannan, B Jordan, TW Secor, WE LaFlamme, AC AF Manivannan (Uradey), Bhagyashree Jordan, Thomas William Secor, William Evan LaFlamme, Anne Camille TI DIFFERENTIAL PATTERNS OF PROTEIN EXPRESSION IN HEPATOSPLENIC SCHISTOSOMIASIS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Manivannan (Uradey), Bhagyashree; Jordan, Thomas William; LaFlamme, Anne Camille] Victoria Univ Wellington, Wellington, New Zealand. [Secor, William Evan] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 742 BP 219 EP 219 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601107 ER PT J AU Eremeeva, ME Dasch, GA Berganza, E Gobern, L Dueger, E Alonso, C Castillo, L Reyes, L Lindblade, K Suarez, G AF Eremeeva, Marina E. Dasch, Gregory A. Berganza, Elsa Gobern, Lorena Dueger, Erica Alonso, Carlos Castillo, Leticia Reyes, Lissette Lindblade, Kimberly Suarez, Gloria TI INVESTIGATION OF AN OUTBREAK OF A FATAL FEBRILE ILLNESS IN GUATEMALA, 2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Eremeeva, Marina E.; Dasch, Gregory A.] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Atlanta, GA USA. [Berganza, Elsa; Gobern, Lorena; Reyes, Lissette] Minist Publ Hlth & Social Welf, Guatemala City, Guatemala. [Dueger, Erica; Lindblade, Kimberly] Ctr Dis Control & Prevent, Div Emerging Infect & Surveillance Serv, Atlanta, GA USA. [Alonso, Carlos; Suarez, Gloria] Ctr Dis Control & Prevent, Field Epidemiol Training Program, Coordinating Off Global Hlth, Atlanta, GA USA. [Alonso, Carlos; Lindblade, Kimberly; Suarez, Gloria] CDC Reg Off Cent Amer & Panama, Guatemala City, Guatemala. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 777 BP 229 EP 229 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601142 ER PT J AU Muok, EM Mwinzi, PN Black, CL Carter, JM Ng'ang'a, ZW Gicheru, MM Secor, WE Karanja, DM Colley, DG AF Muok, Erick M. Mwinzi, Pauline N. Black, Carla L. Carter, Jennifer M. Ng'ang'a, Zopporah W. Gicheru, Michael M. Secor, W. Evan Karanja, Diana M. Colley, Daniel G. TI T LYMPHOCYTE SUBSETS IN CHILDREN WITH SCHISTOSOMIASIS MANSONI COMPARED TO CHILDREN WITH SCHISTOSOMA MANSONI AND PLASMODIUM FALCIPARUM CO-INFECTIONS IN WESTERN KENYA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Muok, Erick M.; Mwinzi, Pauline N.; Karanja, Diana M.] Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Kisumu, Kenya. [Black, Carla L.; Carter, Jennifer M.; Colley, Daniel G.] Univ Georgia, Athens, GA 30602 USA. [Ng'ang'a, Zopporah W.] Jomo Kenyatta Univ Agr & Technol, Nairobi, Kenya. [Gicheru, Michael M.] Kenyatta Univ, Nairobi, Kenya. [Secor, W. Evan] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 788 BP 232 EP 232 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601153 ER PT J AU Morgan, O Chittaganpitch, M Clague, B Sanasuttipun, W Peret, TC Erdman, DD Baggett, HC Olsen, SJ Fry, A AF Morgan, Oliver Chittaganpitch, Malinee Clague, Birgit Sanasuttipun, Wiwar Peret, Teresa C. Erdman, Dean D. Baggett, Henry C. Olsen, Sonja J. Fry, Alicia TI THE EPIDEMIOLOGY OF HUMAN PARAINFLUENZA VIRUS-ASSOCIATED PNEUMONIA IN THAILAND SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Morgan, Oliver; Olsen, Sonja J.] Ctr Dis Control & Prevent, Div Emerging Infect, Atlanta, GA USA. [Morgan, Oliver; Olsen, Sonja J.] Ctr Dis Control & Prevent, Surveillance Serv, Atlanta, GA USA. [Chittaganpitch, Malinee] Thailand Natl Inst Hlth, Minist Publ Hlth, Nonthaburi, Thailand. [Clague, Birgit; Baggett, Henry C.] CDC Collaborat, Thailand MOPH US, Int Emerging Infect Program, Nonthaburi, Thailand. [Sanasuttipun, Wiwar] Sa Kaeo Prov Hlth Off, Sa Kaeo, Thailand. [Peret, Teresa C.; Erdman, Dean D.; Fry, Alicia] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 800 BP 236 EP 236 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601165 ER PT J AU Blair, PJ Wierzba, TF Touch, S Vonthanak, S Garten, RJ Xu, XX Klimov, AI Putnam, SD AF Blair, Patrick J. Wierzba, Thomas F. Touch, Sok Vonthanak, Saphonn Garten, Rebecca J. Xu, Xiyan X. Klimov, Alexander I. Putnam, Shannon D. TI EPIDEMIOLOGY AND GENETIC CHARACTERIZATION OF INFLUENZA VIRUSES ISOLATED FROM PATIENTS ENROLLED IN A HOSPITAL-BASED FEBRILE SURVEILLANCE STUDY IN CAMBODIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Blair, Patrick J.] Naval Hlth Res Ctr, San Diego, CA USA. [Wierzba, Thomas F.] Naval Med Res Unit 2, Phnom Penh, Cambodia. [Touch, Sok] Communicable Dis Control Dept, Phnom Penh, Cambodia. [Vonthanak, Saphonn] Natl Publ Hlth Inst, Phnom Penh, Cambodia. [Garten, Rebecca J.; Xu, Xiyan X.; Klimov, Alexander I.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Putnam, Shannon D.] Naval Med Res Unit 2, Jakarta, Indonesia. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 802 BP 237 EP 237 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601167 ER PT J AU Feikin, D Audi, A Ndirango, J Polyak, C Bigogo, G Olack, B Williamson, J Burke, H Breiman, R AF Feikin, Daniel Audi, Allen Ndirango, James Polyak, Christina Bigogo, Godfrey Olack, Beatrice Williamson, John Burke, Heather Breiman, Robert TI EVALUATION OF SYMPTOM RECALL DURING A TWO-WEEK INTERVAL IN HOME-BASED MORBIDITY SURVEILLANCE, KISUMU AND NAIROBI, KENYA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Feikin, Daniel; Audi, Allen; Polyak, Christina; Bigogo, Godfrey] Ctr Dis Control & Prevent, Kisumu, Kenya. [Ndirango, James; Olack, Beatrice; Burke, Heather; Breiman, Robert] Ctr Dis Control & Prevent, Nairobi, Kenya. [Williamson, John] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 803 BP 237 EP 237 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601168 ER PT J AU Blitvich, BJ Lorono-Pino, MA Garcia-Rejon, JE Hovav, E Powers, AM Lin, M Dorman, KS Platt, KB Bartholomay, LC Farfan-Ale, JA AF Blitvich, Bradley J. Lorono-Pino, Maria A. Garcia-Rejon, Julian E. Hovav, Einat Powers, Ann M. Lin, Ming Dorman, Karin S. Platt, Kenneth B. Bartholomay, Lyric C. Farfan-Ale, Jose A. TI DETECTION OF RNA FROM A NOVEL WEST NILE-LIKE VIRUS AND HIGH PREVALENCE OF AN INSECT-SPECIFIC FLAVIVIRUS IN MOSQUITOES IN THE YUCATAN PENINSULA OF MEXICO SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Blitvich, Bradley J.; Hovav, Einat; Lin, Ming; Dorman, Karin S.; Platt, Kenneth B.; Bartholomay, Lyric C.] Iowa State Univ, Ames, IA USA. [Lorono-Pino, Maria A.; Garcia-Rejon, Julian E.; Farfan-Ale, Jose A.] Univ Autonoma Yucatan, Merida, Yucatan, Mexico. [Powers, Ann M.] Ctr Dis Control & Prevent, Ft Collins, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 809 BP 239 EP 239 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601174 ER PT J AU Komar, N Morales-Betoulle, ME Panella, N Alvarez, D Cordon-Rosales, C AF Komar, Nicholas Morales-Betoulle, Maria Eugenia Panella, Nicholas Alvarez, Danilo Cordon-Rosales, Celia TI ECOLOGY OF WEST NILE VIRUS IN GUATEMALA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Komar, Nicholas; Panella, Nicholas] Ctr Dis Control & Prevent, Ft Collins, CO USA. [Morales-Betoulle, Maria Eugenia; Alvarez, Danilo; Cordon-Rosales, Celia] Ctr Dis Control & Prevent, Guatemala City, Guatemala. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 808 BP 239 EP 239 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601173 ER PT J AU Bukirwa, HF Yau, V Kigozi, R Quick, L Lugemwa, M Dissanayake, G Staedke, SG Kamya, MR Wabwire-Mangen, F Dorsey, G AF Bukirwa, Hasifa F. Yau, Vincent Kigozi, Ruth Quick, Linda Lugemwa, Myers Dissanayake, Gunawardena Staedke, Sarah G. Kamya, Moses R. Wabwire-Mangen, Fred Dorsey, Grant TI ASSESSING THE IMPACT OF INDOOR RESIDUAL SPRAYING ON MALARIA INDICATORS USING A SENTINEL SITE SURVEILLANCE SYSTEM IN WESTERN UGANDA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Bukirwa, Hasifa F.; Kigozi, Ruth] Uganda Malaria Surveillance Project, Kampala, Uganda. [Yau, Vincent] Univ Calif, Berkeley, CA USA. [Quick, Linda] Ctr Dis Control & Prevent, Atlanta, GA USA. [Lugemwa, Myers] Uganda Minist Hlth, Kampala, Uganda. [Dissanayake, Gunawardena] US Agcy Int Dev, Kampala, Uganda. [Staedke, Sarah G.] London Sch Hyg & Trop Med, London WC1, England. [Wabwire-Mangen, Fred] Makerere Univ, Sch Publ Hlth, Kampala, Uganda. [Dorsey, Grant] Univ Calif San Francisco, San Francisco, CA 94143 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 816 BP 241 EP 241 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601181 ER PT J AU Koru, O Brooks, JT Qvarnstrom, Y Eberhard, M Johnston, SP Wilson, M Slutsker, L Hamel, M Shi, YP Chiller, T da Silva, AJ AF Koru, Ozgur Brooks, John T. Qvarnstrom, Yvonne Eberhard, Mark Johnston, Stephanie P. Wilson, Marianna Slutsker, Laurence Hamel, Mary Shi, Ya Ping Chiller, Tom da Silva, Alexandre J. TI DETECTION AND GENOTYPING OF ENTEROCYTOZOON BIENEUSI IN STOOL SPECIMENS FROM HIV-INFECTED RURAL KENYANS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Koru, Ozgur; Qvarnstrom, Yvonne; Eberhard, Mark; Johnston, Stephanie P.; Wilson, Marianna; Slutsker, Laurence; Hamel, Mary; Shi, Ya Ping; da Silva, Alexandre J.] NCZVED, Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA. [Koru, Ozgur] Atlanta Res & Educ Fdn, Atlanta, GA USA. [Brooks, John T.] NCHHSTP, Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. [Chiller, Tom] NCZVED, Div Fungal Bacterial & Mycot Dis, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 826 BP 244 EP 244 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601191 ER PT J AU Vasanthapuram, R Robinson, JS Russell, B Desai, A Ramamurty, N Featherstone, DA Johnson, BW AF Vasanthapuram, Ravi Robinson, Jamie S. Russell, Brandy Desai, Anita Ramamurty, Nalini Featherstone, David A. Johnson, Barbara W. TI EVALUATION OF IGM CAPTURE ELISA ASSAYS FOR THE DETECTION ANTI-JEV IGM ANTIBODIES IN CEREBROSPINAL FLUID SAMPLES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Vasanthapuram, Ravi; Desai, Anita] Natl Inst Mental Hlth & Neurosci, Dept Neurovirol, Bangalore 560029, Karnataka, India. [Robinson, Jamie S.; Russell, Brandy; Johnson, Barbara W.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO USA. [Ramamurty, Nalini] WHO, SE Asia Reg Off, Immunizat & Vaccine Dev, New Delhi, India. [Featherstone, David A.] WHO, CH-1211 Geneva, Switzerland. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 834 BP 246 EP 246 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601199 ER PT J AU Hoel, DF El-Hossary, SS Hanafi, HA Watany, N Fawaz, EY Furman, BD Obernauer, PJ Szumlas, DE Kline, DL AF Hoel, D. F. El-Hossary, S. S. Hanafi, H. A. Watany, N. Fawaz, E. Y. Furman, B. D. Obernauer, P. J. Szumlas, D. E. Kline, D. L. TI RESPONSE OF PHLEBOTOMUS PAPATASI (DIPTERA: PSYCHODIDAE) TO COMMERCIAL MOSQUITO TRAPS IN SOUTHERN EGYPT SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Hoel, D. F.] USDA, Gainesville, FL USA. [El-Hossary, S. S.; Hanafi, H. A.; Watany, N.; Fawaz, E. Y.; Furman, B. D.] USN, Med Res Unit 3, Cairo, Egypt. [Obernauer, P. J.] Univ Florida, Dept Entomol, Gainesville, FL USA. [Obernauer, P. J.] Univ Florida, Dept Nematol, Gainesville, FL USA. [Szumlas, D. E.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Kline, D. L.] Ctr Med Agr & Vet Entomol, Gainesville, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 847 BP 249 EP 250 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601212 ER PT J AU Lee, YM Noh, J Wilkins, P Tsang, VC AF Lee, Yeuk-Mui Noh, John Wilkins, Patricia Tsang, Victor C. TI DEVELOPMENT OF SCHISTOSOMA JAPONICUM FAST-ELISA ASSAY FOR SCHISTOSOMIASIS DIAGNOSIS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Lee, Yeuk-Mui; Noh, John; Wilkins, Patricia] Ctr Dis Control & Prevent, Atlanta, GA USA. [Tsang, Victor C.] Georgia State Univ, Atlanta, GA 30303 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 864 BP 254 EP 255 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601229 ER PT J AU Haidara, FC Sow, SO Brown, O Dia, A Iosi, MPP Marcheti, E Chaumont, J Tapia, M Agdebola, R Idoko, I Arduin, P Borrow, R Carlone, G Akinsola, A Parulekar, V Plikyatis, B Findlow, J Elie, C Laforce, M Kulkarni, P Viviani, S AF Haidara, Fadima Cheick Sow, Samba O. Brown, Okoko Dia, Aldjouma Iosi, Marie Pierre Prez Marcheti, Elisa Chaumont, Julie Tapia, Milagritos Agdebola, Richard Idoko, Ilubukola Arduin, Pascal Borrow, Ray Carlone, Georges Akinsola, Adebayo Parulekar, Varsha Plikyatis, Brian Findlow, Jamie Elie, Cheryl Laforce, Marc Kulkarni, Prasad Viviani, Simonetta TI SAFETY AND IMMUNOGENICITY OF A NEW MENINGOCOCCAL A CONJUGATE VACCINE IN A HEALTHY AFRICAN POPULATION AGED 2-29 YEARS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Haidara, Fadima Cheick; Sow, Samba O.] Ctr Vaccine Dev Mali, Bamako, Mali. [Brown, Okoko] MRC Gambia, Banjul, Gambia. [Dia, Aldjouma; Arduin, Pascal] IRD Dakar, Dakar, Senegal. [Iosi, Marie Pierre Prez] WHO, MVP, CH-1211 Geneva, Switzerland. [Marcheti, Elisa; Chaumont, Julie; Laforce, Marc; Viviani, Simonetta] MVP France, Ferney, France. [Tapia, Milagritos] Ctr Vaccine Dev Mali, Baltimore, MD USA. [Agdebola, Richard; Idoko, Ilubukola; Akinsola, Adebayo] MRC Gambia, Fajara, Gambia. [Borrow, Ray; Findlow, Jamie] HPA, Manchester, Lancs, England. [Carlone, Georges; Plikyatis, Brian; Elie, Cheryl] Ctr Dis Control & Prevent, Atlanta, GA USA. [Parulekar, Varsha] IGATE, Bombay, Maharashtra, India. [Kulkarni, Prasad] SIIL, Pune, Maharashtra, India. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 883 BP 260 EP 260 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601248 ER PT J AU Mercado, X Rivera, Y Wellington, S Hunsperger, E Martinez, I AF Mercado, Xiomara Rivera, Yisel Wellington, Sun Hunsperger, Elizabeth Martinez, Idali TI PASSIVE IMMUNIZATION WITH SERUM FROM SECONDARY DENV PROVIDES PARTIAL CROSS PROTECTION AGAINST WNV INFECTION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Mercado, Xiomara; Rivera, Yisel; Martinez, Idali] Univ Puerto Rico, Dept Microbiol & Med Zool, San Juan, PR USA. [Wellington, Sun; Hunsperger, Elizabeth] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Dengue Branch, San Juan, PR USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 886 BP 261 EP 261 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601251 ER PT J AU Osorio, JE Brewoo, J Kinney, RM Huang, CY Moss, KJ Luy, BE Bowen, RA Livengood, JA Silengo, SJ Kalanidhi, AP Stinchcomb, DT AF Osorio, Jorge E. Brewoo, Joseph Kinney, Richard M. Huang, Claire Y. Moss, Kelly J. Luy, Betty E. Bowen, Richard A. Livengood, Jill A. Silengo, Shawn J. Kalanidhi, A. P. Stinchcomb, Dan T. TI PRECLINICAL EVALUATION OF DENVAX: A CHIMERIC TETRAVALENT DENGUE VACCINE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Osorio, Jorge E.] Univ Wisconsin, Madison, WI USA. [Brewoo, Joseph; Kinney, Richard M.; Livengood, Jill A.; Silengo, Shawn J.; Stinchcomb, Dan T.] Inviragen Inc, Ft Collins, CO USA. [Huang, Claire Y.; Moss, Kelly J.; Luy, Betty E.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO USA. [Bowen, Richard A.] Colorado State Univ, Ft Collins, CO 80523 USA. [Kalanidhi, A. P.] Shantha Biotech Ltd, Hyderabad, Andhra Pradesh, India. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 892 BP 263 EP 263 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601257 ER PT J AU Tomashek, KM Perez, CL Ramos, M Arguello, DF Biggerstaff, B Garcia, E Sun, W AF Tomashek, Kay M. Perez, Carmen L. Ramos, Mary Arguello, D. Fermin Biggerstaff, Brad Garcia, Enid Sun, Wellington TI DENGUE KNOWLEDGE AND PRACTICE, A PHYSICIAN SURVEY IN AN ENDEMIC AREA OF THE U.S SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Tomashek, Kay M.; Perez, Carmen L.; Ramos, Mary; Arguello, D. Fermin; Biggerstaff, Brad; Sun, Wellington] Ctr Dis Control & Prevent, San Juan, PR USA. [Garcia, Enid] Puerto Rico Hlth Dept, San Juan, PR USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 898 BP 264 EP 265 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601263 ER PT J AU Kosoy, O Velez, J Johnson, BW Johnson, J Panella, A Laven, J Lanciotti, R AF Kosoy, Olga Velez, Jason Johnson, Barbara W. Johnson, Jane Panella, Amanda Laven, Janeen Lanciotti, Robert TI DO WE NEED TO USE LABILE SERUM FACTOR FOR DETECTION OF NEUTRALIZING ANTIBODIES IN ARBOVIRAL DIAGNOSTICS? SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Kosoy, Olga; Velez, Jason; Johnson, Barbara W.; Johnson, Jane; Panella, Amanda; Laven, Janeen; Lanciotti, Robert] Ctr Dis Control & Prevent, Ft Collins, CO USA. NR 0 TC 0 Z9 0 U1 4 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 904 BP 266 EP 267 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601269 ER PT J AU Johnson, BW Robinson, J Fadnis, PR Reddy, V Desai, A Vasanthapuram, R AF Johnson, Barbara W. Robinson, Jaimie Fadnis, Prachi Rahul Reddy, Vijayalakshmi Desai, Anita Vasanthapuram, Ravi TI EVALUATION OF NUCLEIC ACID AMPLIFICATION ASSAYS FOR DETECTION OF JAPANESE ENCEPHALITIS VIRUS RNA IN CEREBRAL SPINAL FLUID FROM ACUTE ENCEPHALITIS PATIENTS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Johnson, Barbara W.; Robinson, Jaimie] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO USA. [Fadnis, Prachi Rahul; Reddy, Vijayalakshmi; Desai, Anita; Vasanthapuram, Ravi] Natl Inst Mental Hlth & Neurosci, Dept Neurovirol, Bangalore 560029, Karnataka, India. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 905 BP 267 EP 267 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601270 ER PT J AU Ramey, KI Eko, FO Wilson, N Kucerova, Z Thompson, W Stiles, JK AF Ramey, Kiantra I. Eko, Francis O. Wilson, Nana Kucerova, Zuzana Thompson, Winston Stiles, Jonathan K. TI IDENTIFICATION, CHARACTERIZATION, AND EVALUATION OF THE TRYPANOSOMA BRUCEI CA(2+) CHANNEL (TBCC1) AS A POTENTIAL DRUG AND VACCINE TARGET SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Ramey, Kiantra I.; Eko, Francis O.; Wilson, Nana; Thompson, Winston; Stiles, Jonathan K.] Morehouse Sch Med, Atlanta, GA 30310 USA. [Kucerova, Zuzana] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 SU S MA 917 BP 270 EP 270 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601282 ER PT J AU Bruxvoort, KJ Khatib, RA Abdulla, SM Kahigwa, E Kachur, SP McMorrow, ML AF Bruxvoort, Katia J. Khatib, Rashid A. Abdulla, Salim M. Kahigwa, Elizeus Kachur, S. Patrick McMorrow, Meredith L. TI VARIABLE SENSITIVITY OF MALARIA RAPID DIAGNOSTIC TESTS IN HOUSEHOLD SURVEYS-TANZANIA, 2006 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Bruxvoort, Katia J.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Khatib, Rashid A.; Abdulla, Salim M.; Kahigwa, Elizeus] Ifakara Hlth Res & Dev Ctr, Ifakara, Tanzania. [Kachur, S. Patrick; McMorrow, Meredith L.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 956 BP 281 EP 281 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601321 ER PT J AU Mixson-Hayden, T McCollum, AM Jain, V Nagpal, AC Dash, AF Stiles, JK Udhayakumar, V Singh, N AF Mixson-Hayden, Tonya McCollum, Andrea M. Jain, Vidhan Nagpal, Avinash C. Dash, Aditya F. Stiles, Jonathan K. Udhayakumar, Venkatachalam Singh, Neeru TI CHLOROQUINE AND SULPHADOXINE-PYRIMETHAMINE RESISTANT GENOTYPES OF PLASMODIUM FALCIPARUM IN MILD MALARIA AND CEREBRAL MALARIA PATIENTS IN INDIA WITH EVIDENCE OF SELECTIVE SWEEPS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Mixson-Hayden, Tonya; McCollum, Andrea M.; Udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Atlanta, GA USA. [Jain, Vidhan; Dash, Aditya F.; Singh, Neeru] Natl Inst Malaria Res, Jabalpur, India. [Nagpal, Avinash C.] Nethaji Subash Chandra Bose Hosp, Jabalpur, India. [Stiles, Jonathan K.] Morehouse Sch Med, Atlanta, GA 30310 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 984 BP 289 EP 289 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601348 ER PT J AU Kayentao, K Maiga, H Newman, RD McMorrow, ML Yattara, O Traore, H Kone, Y Guirou, E Saye, R Traore, B Djimde, A Doumbo, OK AF Kayentao, Kassoum Maiga, Hamma Newman, Robert D. McMorrow, Meredith L. Yattara, Oumar Traore, Hamidou Kone, Younoussou Guirou, Etienne Saye, Reunion Traore, Boubacar Djimde, Abdoulaye Doumbo, Ogobara K. TI ARTEMISININ-BASED COMBINATIONS VERSUS AMODIAQUINE PLUS SULFADOXINE-PYRIMETHAMINE FOR THE TREATMENT OF UNCOMPLICATED MALARIA IN FALADJE, MALI SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Newman, Robert D.; McMorrow, Meredith L.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Kayentao, Kassoum; Maiga, Hamma; Yattara, Oumar; Traore, Hamidou; Kone, Younoussou; Guirou, Etienne; Saye, Reunion; Traore, Boubacar; Djimde, Abdoulaye; Doumbo, Ogobara K.] MRTC FMPOS, Bamako, Mali. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 987 BP 290 EP 290 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601351 ER PT J AU Lima-Junior, JC Tran, T Meyer, EV De-Simone, SG Santos, F Moreno, A Porto, LCS Banic, DM Barnwell, JW Galinski, MR Oliveira-Ferreira, J AF Lima-Junior, Josu C. Tran, Tuan Meyer, Esmeralcla V. De-Simone, Salvatore G. Santos, Fatima Moreno, Alberto Porto, Luiz Cristovao S. Banic, Dalma M. Barnwell, John W. Galinski, Mary R. Oliveira-Ferreira, Joseli TI IFN-gamma AND IL-4 RESPONSES INDUCED BY PROMISCUOUS T-CELL EPITOPES OF PLASMODIUM VIVAX MEROZOITE SURFACE PROTEIN 9 (PVMSP9) IN MALARIA NATURALLY EXPOSED INDIVIDUALS IN BRAZIL SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Barnwell, John W.] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Infect Dis, Atlanta, GA USA. [Moreno, Alberto; Galinski, Mary R.] Emory Univ, Sch Med, Emory Vaccine Ctr, Div Infect Dis, Atlanta, GA USA. [Porto, Luiz Cristovao S.] Univ Estado Rio De Janeiro, Histocompatibil Lab, Rio De Janeiro, Brazil. [Santos, Fatima] FUNASA, Dept Entomol, Rondonia, Brazil. [De-Simone, Salvatore G.] Inst Oswaldo Cruz, Prot & Peptides Lab, BR-20001 Rio De Janeiro, Brazil. [Lima-Junior, Josu C.; Banic, Dalma M.; Oliveira-Ferreira, Joseli] Fiocruz MS, Inst Oswaldo Cruz, Lab Malaria Res, BR-21045900 Rio De Janeiro, Brazil. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 999 BP 293 EP 294 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601363 ER PT J AU Bharti, PK Singh, PP Jain, V Kauth, CW Woehlbier, U Udhayakumar, V Sharma, YD Gautam, SP Dash, AP Singh, N AF Bharti, Praveen Kumar Singh, Puspendra Pal Jain, Vidhan Kauth, Christian W. Woehlbier, Ute Udhayakumar, V Sharma, Yagya D. Gautam, Sant P. Dash, Aditya P. Singh, Neeru TI ANTIBODY RESPONSES TO THE MEROZITE SURFACE PROTEIN (MSP) COMPLEX OF PLASMODIUM FALCIPARUM IN MALARIA PATIENTS FROM CENTRAL INDIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Singh, Neeru] Reg Med Res Ctr Tribal ICMR, Jabalpur, India. [Dash, Aditya P.] Natl Inst Malaria Res ICMR, New Delhi, India. [Gautam, Sant P.] Rani Durgavati Vishwavidyala, Dept Biol Sci, Jabalpur, India. [Sharma, Yagya D.] All India Inst Med Sci, Dept Biotechnol, New Delhi 110029, India. [Udhayakumar, V] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis, Atlanta, GA USA. [Kauth, Christian W.; Woehlbier, Ute] Univ Heidelberg, Zentrum Mol Biol Heidelberg ZMBH, Heidelberg, Germany. [Bharti, Praveen Kumar; Singh, Puspendra Pal; Jain, Vidhan] Natl Inst Malaria Res Field Stn, Jabalpur, India. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 1011 BP 297 EP 297 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601375 ER PT J AU Singh, PP Lucchil, NW Ahmed, R Terlouw, AD ter Kuile, F Udhayakumar, V Singh, N AF Singh, Puspendra Pal Lucchil, Naomi W. Ahmed, Rukshana Terlouw, Anja D. ter Kuile, Feiko Udhayakumar, Venkatachalam Singh, Neeru TI MACROPHAGE MIGRATION INHIBITORY FACTOR IN PLACENTAL INTERVILLOUS BLOOD PLASMA AND ITS ASSOCIATION WITH BIRTH OUTCOMES IN PLASMODIUM FALCIPARUM INFECTED WOMEN IN CENTRAL INDIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Singh, Puspendra Pal] Natl Inst Malaria Res, Field Stn, ICMR, Jabalpur, India. [Lucchil, Naomi W.; Udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis, Atlanta, GA USA. [Ahmed, Rukshana; Terlouw, Anja D.; ter Kuile, Feiko] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England. [Singh, Neeru] Reg Med Res Ctr Tribal ICMR, Jabalpur, India. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 1013 BP 298 EP 298 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601377 ER PT J AU Kariuki, SK Ndanu, AM Njunge, JM Muiuvi, GM Gatei, W ter Kuile, FO Terlouw, DJ Hawley, WA Phillips-Howard, PA Nahlen, BL Gimnig, JE Lindblade, KA Hamel, MJ Williamson, J Escalante, A Slutsker, L Shi, YP AF Kariuki, Simon K. Ndanu, Ann M. Njunge, James M. Muiuvi, Geoffrey M. Gatei, Wangeci ter Kuile, Feiko O. Terlouw, Dianne J. Hawley, William A. Phillips-Howard, Penelope A. Nahlen, Bernard L. Gimnig, John E. Lindblade, Kim A. Hamel, Mary J. Williamson, John Escalante, Ananias Slutsker, Laurence Shi, Ya Ping TI EFFECT OF INSECTICIDE-TREATED BED NETS (ITNS) ON GENE POLYMORPHISMS OF PLASMODIUM FALCIPARUM VACCINE CANDIDATE ANTIGENS IN A MALARIA HOLOENDEMIC AREA OF WESTERN KENYA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Kariuki, Simon K.] Kenya Govt Med Res Ctr, Kisumu, Kenya. [Ndanu, Ann M.; Njunge, James M.; Muiuvi, Geoffrey M.] Kenyatta Univ, Nairobi, Kenya. [Gatei, Wangeci; Hawley, William A.; Phillips-Howard, Penelope A.; Gimnig, John E.; Lindblade, Kim A.; Hamel, Mary J.; Williamson, John; Slutsker, Laurence; Shi, Ya Ping] Ctr Dis Control & Prevent, Atlanta, GA USA. [ter Kuile, Feiko O.; Terlouw, Dianne J.] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England. [Nahlen, Bernard L.] Presidents Malaria Initiat, Washington, DC USA. [Escalante, Ananias] Arizona State Univ, Tempe, AZ USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 1033 BP 303 EP 304 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601397 ER PT J AU Kilian, A Nery, S Casimiro, S Cuamba, N Pigeon, O Gimnig, J AF Kilian, Albert Nery, Susana Casimiro, Sonia Cuamba, Nelson Pigeon, Olivier Gimnig, John TI FIELD PERFORMANCE OF A WASH RESISTANT INSECTICIDE TREATMENT KIT FOR MOSQUITO NETS IN THREE DIFFERENT SETTINGS IN UGANDA AND MOZAMBIQUE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Kilian, Albert] Malaria Consortium, Montagut, Spain. [Nery, Susana] Malaria Consortium, Maputo, Mozambique. [Casimiro, Sonia; Cuamba, Nelson] Natl Inst Hlth, Maputo, Mozambique. [Pigeon, Olivier] Ctr Wallon Rech Agron, Gembloux, Belgium. [Gimnig, John] Ctr Dis Control & Prevent, Atlanta, GA USA. RI Vaz Nery, Susana/P-4518-2014 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 1052 BP 309 EP 309 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601416 ER PT J AU Kyelem, D Biswas, G Bockarie, M Bradley, M EI-Setouhy, MES Fischer, P Henderson, R Kazura, J Lammie, PJ Njenga, SM Ottesen, EA Ramaiah, K Richards, F Weill, G Willliams, S AF Kyelem, Dominique Biswas, Gautam Bockarie, Moses Bradley, Mark EI-Setouhy, Maged El-Setouhy Fischer, Peter Henderson, Ralph Kazura, James Lammie, Patrick J. Njenga, Sammy M. Ottesen, Eric A. Ramaiah, Kapa Richards, Frank Weill, Gary Willliams, Steve TI DETERMINANTS AFFECTING OUTCOMES OF NATIONAL PROGRAMS TO ELIMINATE LYMPHATIC FILARIASIS (LF): DEFINING RESEARCHABLE PRIORITIES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Kyelem, Dominique; Henderson, Ralph; Ottesen, Eric A.] Lymphat Filariasis Support Ctr, Decatur, GA USA. [Biswas, Gautam] WHO, CH-1211 Geneva, Switzerland. [Bockarie, Moses; Kazura, James] Case Western Reserve Univ, Cleveland, OH 44106 USA. [Bradley, Mark] GlaxoSmithKline Inc, London, England. [EI-Setouhy, Maged El-Setouhy] Ain Shams Univ, Cairo, Egypt. [Fischer, Peter; Weill, Gary] Washington Univ, St Louis, MO USA. [Lammie, Patrick J.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Njenga, Sammy M.] Kenya Govt Med Res Ctr, Nairobi, Kenya. [Ramaiah, Kapa] Vector Control Res Ctr, Pondicherry, India. [Richards, Frank] Emory Univ, Carter Ctr, Atlanta, GA 30322 USA. [Willliams, Steve] Smith Coll, Clark Sci Ctr, Northampton, MA 01063 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 1112 BP 325 EP 325 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601475 ER PT J AU Chambers, EW Mladonicky, J King, JD Liang, JL McClintock, SK Schmaedick, MA Pa'au, M Bradley, MH Burkot, TR Lammie, PJ AF Chambers, Eric W. Mladonicky, Janice King, Jonathan D. Liang, Jennifer L. McClintock, Shannon K. Schmaedick, Mark A. Pa'au, Molisamoa Bradley, Mark H. Burkot, Thomas R. Lammie, Patrick J. TI SPATIAL MODELING OF LYMPHATIC FILARIASIS RISK IN AMERICAN SAMOA BASED ON EPIDEMIOLOGICAL AND ENTOMOLOGICAL DATA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Chambers, Eric W.; Mladonicky, Janice; King, Jonathan D.; Liang, Jennifer L.; McClintock, Shannon K.; Burkot, Thomas R.; Lammie, Patrick J.] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA. [Schmaedick, Mark A.] Amer Samoa Community Coll, Div Community & Nat Resources, Pago Pago, AS USA. [Pa'au, Molisamoa] Amer Samoa Dept Hlth, Pago Pago, AS USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 1114 BP 326 EP 326 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601477 ER PT J AU Supali, T Noordin, R Liauw, F Wibowo, H Mohd, TAA Wong, KY Fischer, PU Weil, GJ AF Supali, Taniawati Noordin, Rahmah Liauw, Felix Wibowo, Heri Mohd, Tajul A. Awang Wong, Kimberly Y. Fischer, Peter U. Weil, Gary J. TI EVALUATION OF DIAGNOSTIC TOOLS FOR BRUGIAN FILARIASIS ELIMINATION PROGRAMS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Supali, Taniawati; Liauw, Felix; Wibowo, Heri] Univ Indonesia, Jakarta, Indonesia. [Noordin, Rahmah] Univ Sains Malaysia, George Town, Malaysia. [Mohd, Tajul A. Awang] Sabah Hlth Off, Vector Borne Dis Sect, Kota Kinabalu, Malaysia. [Wong, Kimberly Y.] Ctr Dis Control, Atlanta, GA 30333 USA. [Fischer, Peter U.; Weil, Gary J.] Washington Univ, Sch Med, St Louis, MO USA. RI Noordin, Rahmah/A-8277-2011 OI Noordin, Rahmah/0000-0001-7583-0752 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 1113 BP 326 EP 326 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601476 ER PT J AU Cantey, PT Rout, J Rao, G Dhir, S Fox, L AF Cantey, Paul T. Rout, Jonathan Rao, Grace Dhir, Soumendra Fox, LeAnne TI INCREASING ADHERENCE TO MASS DRUG ADMINISTRATION FOR LYMPHATIC FILARIASIS - ORISSA STATE, INDIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Cantey, Paul T.; Fox, LeAnne] Ctr Dis Control & Prevent, Atlanta, GA USA. [Rout, Jonathan; Rao, Grace; Dhir, Soumendra] Churchs Auxiliary Social Act, Bhubaneswar, Orissa, India. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 1118 BP 327 EP 327 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601481 ER PT J AU Xiao, LH Hlavsa, M Yoder, J Ewers, C Dearen, T Nett, R Harris, S Brend, S Harris, M Onischuk, L Valderrama, AL Cosgrove, S Xiavier, K Hall, N Romero, S Young, S Johnston, SP Arrowood, M Roy, S Beach, MJ AF Xiao, Lihua Hlavsa, Michele Yoder, Jonathan Ewers, Christina Dearen, Theresa Nett, Randall Harris, Stephanie Brend, Sarah Harris, Maghan Onischuk, Lisa Valderrama, Amy L. Cosgrove, Shaun Xiavier, Karen Hall, Nancy Romero, Sylvia Young, Stephen Johnston, Stephanie P. Arrowood, Michael Roy, Sharon Beach, Michael J. TI UNDERSTANDING TRANSMISSION OF CRYPTOSPORIDIOSIS IN THE UNITED STATES, 2007: MOLECULAR ANALYSIS OF SPORADIC CRYPTOSPORIDIUM ISOLATES WITH A CASE REPORT OF A HUMAN INFECTION WITH CRYPTOSPORIDIUM HORSE GENOTYPE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Xiao, Lihua; Hlavsa, Michele; Yoder, Jonathan; Dearen, Theresa; Valderrama, Amy L.; Johnston, Stephanie P.; Arrowood, Michael; Roy, Sharon; Beach, Michael J.] Ctr Dis Control & Prevent, Chamblee, GA USA. [Ewers, Christina; Onischuk, Lisa] New Mexico Dept Hlth, Santa Fe, NM USA. [Nett, Randall] Idaho Dept Hlth & Welf, Boise, ID USA. [Harris, Stephanie] EPA Reg Lab, Port Orchard, WA USA. [Brend, Sarah; Harris, Maghan; Hall, Nancy] Iowa Dept Publ Hlth, Des Moines, IA 50319 USA. [Cosgrove, Shaun; Xiavier, Karen] Colorado Dept Publ Hlth & Environm, Denver, CO USA. [Romero, Sylvia; Young, Stephen] Tricore Reference Labs, Albuquerque, NM USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 1140 BP 334 EP 334 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601503 ER PT J AU Graczyk, T Sunderland, D Rule, A DaSilva, A Moura, L Girouard, A Schwab, K Breyssel, P AF Graczyk, Thaddeus Sunderland, Deirdre Rule, Ana DaSilva, Alexandre Moura, Laci Girouard, Autumn Schwab, Kellogg Breyssel, Patrick TI URBAN FERAL PIGEONS (COLUMBIA LIVIA) AS A SOURCE FOR AIR-AN D-WATER BORNE CONTAMINATION WITH ENTEROCYTOZOON BIENEUSI SPORES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Graczyk, Thaddeus; Sunderland, Deirdre; Rule, Ana; Girouard, Autumn; Schwab, Kellogg; Breyssel, Patrick] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. [DaSilva, Alexandre; Moura, Laci] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 1143 BP 335 EP 335 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601506 ER PT J AU Jones, JL Dargelas, V Roberts, J Press, C Remington, JS Montoya, JG AF Jones, Jeffrey L. Dargelas, Valerie Roberts, Jacquelin Press, Cynthia Remington, Jack S. Montoya, Jose G. TI SOURCES OF TOXOPLASMA GONDII INFECTION IN THE UNITED STATES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Jones, Jeffrey L.; Roberts, Jacquelin] Ctr Dis Control & Prevent, Atlanta, GA USA. [Remington, Jack S.; Montoya, Jose G.] Stanford Univ, Sch Med, Palo Alto Med Fdn, Res Inst, Palo Alto, CA 94304 USA. [Remington, Jack S.; Montoya, Jose G.] Stanford Univ, Sch Med, Div Infect Dis, Dept Med, Palo Alto, CA 94304 USA. [Remington, Jack S.; Montoya, Jose G.] Stanford Univ, Sch Med, Palo Alto Med Fdn, Res Inst, Stanford, CA 94305 USA. [Remington, Jack S.; Montoya, Jose G.] Stanford Univ, Sch Med, Dept Med, Div Infect Dis, Stanford, CA 94305 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 1142 BP 335 EP 335 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601505 ER PT J AU Won, KY de Rochars, MB Kyelem, D Laney, SJ Williams, SA Streit, T Lammie, PJ AF Won, Kimberly Y. de Rochars, Madsen Beau Kyelem, Dominique Laney, Sandra J. Williams, Steven A. Streit, Thomas Lammie, Patrick J. TI ONE STEP FORWARD, TWO STEPS BACK? ASSESSING THE IMPACT OF A MISSED MDA CYCLE IN HAITI SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Won, Kimberly Y.; Lammie, Patrick J.] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA. [de Rochars, Madsen Beau] Hop St Croix, Leogane, Haiti. [Kyelem, Dominique] Emory Univ, Task Force Child Survival & Dev, Decatur, GA USA. [Laney, Sandra J.; Williams, Steven A.] Smith Coll, Dept Biol Sci, Clark Sci Ctr, Northampton, MA USA. [Streit, Thomas] Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 1154 BP 338 EP 339 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601517 ER PT J AU da Silva, ACA Qvarnstrom, Y Bishop, HS Graeff-Teixeira, C da Silva, AJ AF da Silva, Ana Cristina A. Qvarnstrom, Yvonne Bishop, Henry S. Graeff-Teixeira, Carlos da Silva, Alexandre J. TI DEVELOPMENT OF A REAL-TIME PCR ASSAY FOR SPECIFIC DETECTION OF ANGIOSTRONGYLUS CANTONENSIS IN CLINICAL AND ENVIRONMENTAL SAMPLES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [da Silva, Ana Cristina A.; Graeff-Teixeira, Carlos] Pontificia Univ Catolica Rio Grande do Sul, Porto Alegre, RS, Brazil. [Qvarnstrom, Yvonne; Bishop, Henry S.; da Silva, Alexandre J.] NCZVED, Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA. RI Graeff-Teixeira, Carlos/A-5820-2012 OI Graeff-Teixeira, Carlos/0000-0003-2725-0061 NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 1176 BP 345 EP 345 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601539 ER PT J AU Bern, C Calderon, M LaFuente, C Galdos, G Abastorflorl, MD Aparicio, H Brady, M Ferrufino, L Verastegui, M Gilman, RH Naquira, C AF Bern, Caryn Calderon, Maritza LaFuente, Carlos Galdos, Gerson del Carmen Abastorflorl, Maria Aparicio, Hugo Brady, Mark Ferrufino, Lisbeth Verastegui, Manuela Gilman, Robert H. Naquira, Cesar TI CONGENITAL CHAGAS DISEASE TRANSMISSION IN SANTA CRUZ, BOLIVIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Bern, Caryn] Ctr Dis Control & Prevent, Atlanta, GA USA. [Calderon, Maritza; Verastegui, Manuela; Naquira, Cesar] Univ Peruana Cayetano Heredia, Lima, Peru. [LaFuente, Carlos; del Carmen Abastorflorl, Maria; Ferrufino, Lisbeth] Hosp Univ Japones, Santa Cruz, Bolivia. [Galdos, Gerson] Asociac Benef PRISMA, Lima, Philippines. [Aparicio, Hugo; Brady, Mark] Asociac Benef PRISMA, Lima, Peru. [Gilman, Robert H.] Johns Hopkins Univ, Sch Publ Hlth, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 1201 BP 353 EP 353 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601564 ER PT J AU Ssekabira, U Bukirwa, H Hopkins, H Namagembc, A Weaver, MR Scbuyira, LM Quick, L Staedke, S Yeka, A Kiggundu, M Schneider, G McAdam, K Wabwire-Mangen, F Dorsey, G AF Ssekabira, Umaru Bukirwa, Hasifa Hopkins, Heidi Namagembc, Allen Weaver, Marcia R. Scbuyira, Lydia Mpanga Quick, Linda Staedke, Sarah Yeka, Adoke Kiggundu, Moses Schneider, Gisela McAdam, Keith Wabwire-Mangen, Fred Dorsey, Grant TI Improved Malaria Case Management after Integrated Team-based Training of Health Care Workers in Uganda SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PRESUMPTIVE DIAGNOSIS; RANDOMIZED-TRIAL; OVER-DIAGNOSIS; CHILDREN; MICROSCOPY; ZAMBIA; AREA; TANZANIA; DISTRICT AB Malaria case management in Africa is characterized by presumptive treatment and substantial overtreatment. We evaluated all integrated team-based training program on malaria case management. Surveillance data 120 days before and after training were compared at eight health facilities in Uganda. After training, the proportion of patients with suspected malaria referred for blood smears increased from 38.3%, to 54.6% (P = 0.04) in persons < 5 years of age years and front 34.1% to 53.4% (P = 0.02) in those >= 5 years of age. The proportion of patients with negative blood smears prescribed antimalarial drugs decreased from 47.9% to 19.6% (P < 0.001) in persons <5 years of age and from 38.8% to 15.6% (P < 0.001) in those >= 5 years of age. Training did not improve the proportion of patients with positive blood smears prescribed antimalarial drugs, the proportion of patients prescribed appropriate antimalarial drugs or the diagnostic accuracy of microscopy. Integrated team-based training may improve malaria case management and reduce the number of unnecessary antimalarial treatments. C1 Joint Uganda Malaria Training Program, Kampala, Uganda. Uganda Malaria Surveillance Project, Kampala, Uganda. Univ Calif San Francisco, Dept Med, San Francisco Gen Hosp, San Francisco, CA 94143 USA. HIV I TECH, Dept Hlth Serv & Int Training, Seattle, WA USA. HIV I TECH, Educ Ctr, Seattle, WA USA. Makerere Univ, Infect Dis Inst, Kampala, Uganda. Makerere Univ, Sch Publ Hlth, Kampala, Uganda. Ctr Dis Control & Prevent, Atlanta, GA USA. London Sch Hyg & Trop Med, London WC1, England. RP Dorsey, G (reprint author), Univ Calif San Francisco, Box 0811, San Francisco, CA 94143 USA. EM gdorsey@medsfgh.ucsf.edu FU Exxon Mobil Corporation; Centers for Disease Control and Prevention [U50/CCU925122]; National Institutes of Health [AI065457-01]; Doris Duke Charitable Foundation Clinical Scientist Development Award FX The study was supported by the Exxon Mobil Corporation. the Centers for Disease Control and Prevention (U50/CCU925122). and the National Institutes of Health (AI065457-01). Grant Dorsey is it recipient of the Doris Duke Charitable Foundation Clinical Scientist Development Award. NR 25 TC 41 Z9 41 U1 1 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 BP 826 EP 833 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZR UT WOS:000261644400004 PM 19052287 ER PT J AU Reimann, CA Hayes, EB DiGuiseppi, C Hoffman, R Lehman, JA Lindsey, NP Campbell, GL Fischer, M AF Reimann, Carolyn A. Hayes, Edward B. DiGuiseppi, Carolyn Hoffman, Richard Lehman, Jennifer A. Lindsey, Nicole P. Campbell, Grant L. Fischer, Marc TI Epidemiology of Neuroinvasive Arboviral Disease in the United States, 1999-2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID WEST-NILE-VIRUS; ENCEPHALITIS; INFECTION AB From 1999-2007, the most Common causes Of neuroinvasive arboviral disease in the United States, after West Nile Virus (WNV), were California (CAL) serogroup viruses, St. Louis encephalitis Virus (SLEV). and eastern equine encephalitis Virus (EEEV). The CAL serogroup Virus disease was primarily reported from Appalachia and the upper Midwest, SLEV disease from Southern states. and EEEV disease from areas along the Atlantic and Gulf coasts. Children accounted for 88% of CAL serogroup virus disease, whereas 75%, of SLEV disease occurred among older adults. The EEEV disease had the highest case-fatality rate (42%). The incidence of CAL serogroup Virus and EEEV disease remained stable before and after the detection of WNV in the United States in 1999. The SLEV disease declined 3-fold after 1999: however, SLEV disease has Occurred in sporadic epidemics that make trends difficult to interpret. The CAL serogroup Virus, SLEV, and EEEV disease are persistent public health Concerns ill the United States warranting, ongoing! prevention efforts. C1 [Fischer, Marc] CDC, Arboviral Dis Branch, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA. Univ Colorado, Colorado Sch Publ Hlth, Denver, CO 80202 USA. RP Fischer, M (reprint author), CDC, Arboviral Dis Branch, Div Vector Borne Infect Dis, 3150 Rampart Rd, Ft Collins, CO 80521 USA. EM mfischer@cdc.gov FU Centers for Disease Control and Prevention FX This work was funded by the Centers for Disease Control and Prevention. NR 29 TC 61 Z9 65 U1 1 U2 9 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 BP 974 EP 979 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZR UT WOS:000261644400031 PM 19052314 ER PT J AU Jagoda, AS Bazarian, JJ Bruns, JJ Cantrill, SV Gean, AD Howard, PK Ghajar, J Wright, DW Wears, RL Burgess, P Wald, MM Whitson, RR AF Jagoda, Andy S. Bazarian, Jeffrey J. Bruns, John J. Cantrill, Stephen V. Gean, Alisa D. Howard, Patricia Kunz Ghajar, Jamshid Wright, David W. Wears, Robert L. Burgess, Paula Wald, Marlena M. Whitson, Rhonda R. TI Clinical Policy: Neuroimaging and Decisionmaking in Adult Mild Traumatic Brain Injury in the Acute Setting SO ANNALS OF EMERGENCY MEDICINE LA English DT Article ID MINOR HEAD-INJURY; EMERGENCY-DEPARTMENT DISCHARGE; RANDOMIZED CONTROLLED-TRIAL; COMPUTED-TOMOGRAPHY SCAN; DIFFUSE AXONAL INJURY; NEW-ORLEANS CRITERIA; INTRACRANIAL INJURY; BIOCHEMICAL MARKERS; ELDERLY-PATIENTS; BLUNT TRAUMA AB This clinical policy provides evidence-based recommendations on select issues in the management of adult clinical policy are: (1) Which patients with mild TBI should have a noncontrast head computed tomography (CT) scan in the emergency department (ED)? (2) Is there a role for head magnetic resonance imaging over noncontrast CT in the ED evaluation of a patient with acute mild TBI? (3) In patients with mild TBI, are brain specific serum biomarkers predictive of an acute traumatic intracranial injury? (4) Can a patient with an isolated mild TBI and a normal neurologic evaluation result be safely discharged from the ED if a noncontrast head CT scan shows no evidence of intracranial injury? Inclusion criteria for application of this clinical policy's recommendations are nonpenetrating trauma to the head, presentation to the ED within 24 hours of injury a Glasgow Coma Scale score of 14 or 15 on initial evaluation in the ED, and aged 16 years or greater. The primary outcome measure for questions 1, 2, and 3 is the presence of an acute intracranial injury on noncontrast head CT scan; the primary outcome measure for question 4 is the occurrence of neurologic deterioration. C1 [Jagoda, Andy S.; Bazarian, Jeffrey J.; Bruns, John J.; Cantrill, Stephen V.; Gean, Alisa D.; Howard, Patricia Kunz; Ghajar, Jamshid; Wright, David W.; Wears, Robert L.; Burgess, Paula; Wald, Marlena M.] Ctr Dis Control & Prevent, Div Injury Response, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA. RP Jagoda, AS (reprint author), Ctr Dis Control & Prevent, Div Injury Response, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA. RI Wright, David/F-1209-2013; OI Wright, David/0000-0002-7145-9105; Wears, Robert/0000-0001-9826-954X NR 83 TC 150 Z9 152 U1 2 U2 9 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD DEC PY 2008 VL 52 IS 6 BP 714 EP 748 DI 10.1016/j.annemergmed.2008.08.021 PG 35 WC Emergency Medicine SC Emergency Medicine GA 381MJ UT WOS:000261540200017 PM 19027497 ER PT J AU Harrison, KM Ling, Q Song, R Hall, HI AF Harrison, Kathleen McDavid Ling, Qiang Song, Ruiguang Hall, H. Irene TI County-Level Socioeconomic Status and Survival After HIV Diagnosis, United States SO ANNALS OF EPIDEMIOLOGY LA English DT Article DE HIV surveillance; Race/ethnicity; Relative survival; Socioeconomic status; United States ID DISPARITIES GEOCODING PROJECT; ACTIVE ANTIRETROVIRAL THERAPY; INFECTED PATIENTS; RELATIVE SURVIVAL; AIDS INCIDENCE; MEDICAL-CARE; DRUG-USE; WOMEN; HEALTH; MORTALITY AB PURPOSE: To estimate relative survival (RS) after human immunodeficiency virus (HIV) diagnosis, by race/ethnicity and county-level socioeconomic status (SES). METHODS: We estimated 5-year RS by age, race/ethnicity, transmission category, sex, diagnosis year, CD4 count, and by county-level SES variables from the U.S. Census. Data, from the national HIV/AIDS Reporting System, were for HIV-infected persons ages >= 13 years (diagnosis during 1996-2003 and follow-up through 2005). We calculated RS proportions by using a maximum likelihood algorithm and modeled the relative risk of excess death (RR) using generalized linear models, with poverty as a random effect. RESULTS: For men, RS was worse in Counties with larger proportions of people living below the 2000 U.S. poverty level (87.7% for poverty of >= 20% vs. 90.1% for poverty of < 5.0%) and where unemployment was greater (87.8% where unemployment > 7.1% vs. 90.5% where unemployment < 4.0%). The effects of county-level SES on RS of women were similar. In multilevel multivariate models, RR for men and women within 5 years after an HIV diagnosis was significantly worse in counties where 10.0-19.9% (compared with < 5.0%) lived below the poverty level (RR = 1.3 [95% CI 1.2-1.5] and RR = 1.8 [95% CI 1.4-2.2], respectively). CONCLUSIONS: RS was worse in lower SES areas. To help address the impact of county-level SES, resources for HIV testing, care, and proven economic interventions should be directed to areas with concentrations of economically disadvantaged people. C1 [Harrison, Kathleen McDavid; Ling, Qiang; Song, Ruiguang; Hall, H. Irene] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. RP Harrison, KM (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, 1600 Clifton Rd NE,Mailstop E-47, Atlanta, GA 30333 USA. EM KMcDavid@cdc.gov NR 74 TC 28 Z9 28 U1 2 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1047-2797 J9 ANN EPIDEMIOL JI Ann. Epidemiol. PD DEC PY 2008 VL 18 IS 12 BP 919 EP 927 DI 10.1016/j.annepidem.2008.09.003 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 387GI UT WOS:000261939300007 ER PT J AU Saaddine, JB Honeycutt, AA Narayan, KMV Zhang, XZ Klein, R Boyle, JP AF Saaddine, Jinan B. Honeycutt, Amanda A. Narayan, K. M. Venkat Zhang, Xinzhi Klein, Ron Boyle, James P. TI Projection of Diabetic Retinopathy and Other Major Eye Diseases Among People With Diabetes Mellitus United States, 2005-2050 SO ARCHIVES OF OPHTHALMOLOGY LA English DT Article ID OPEN-ANGLE GLAUCOMA; BEAVER DAM EYE; NORTH-DAKOTA; RISK-FACTORS; PREVALENCE; ADULTS; CARE; POPULATION; CATARACT; BURDEN AB Objectives: To estimate the number of people with diabetic retinopathy (DR), vision-threatening DR (VTDR), glaucoma, and cataracts among Americans 40 years or older with diagnosed diabetes mellitus for the years 2005-2050. Methods: Using published prevalence data of DR, VTDR, glaucoma, and cataracts and data from the National Health Interview Survey and the US Census Bureau, we projected the number of Americans with diabetes with these eye conditions. Results: The number of Americans 40 years or older with DR and VTDR will triple in 2050, from 5.5 million in 2005 to 16.0 million for DR and from 1.2 million in 2005 to 3.4 million for VTDR. Increases among those 65 years or older will be more pronounced (2.5 million to 9.9 million for DR and 0.5 million to 1.9 million for VTDR). The number of cataract cases among whites and blacks 40 years or older with diabetes will likely increase 235% by 2050, and the number of glaucoma cases among Hispanics with diabetes 65 years or older will increase 12-fold. Conclusion: Future increases in the number of Americans with diabetes will likely lead to significant increases in the number with DR, glaucoma, and cataracts. Our projections may help policy makers anticipate future demands for health care resources and possibly guide the development of targeted interventions. C1 [Saaddine, Jinan B.; Narayan, K. M. Venkat; Zhang, Xinzhi; Boyle, James P.] Ctr Dis Control & Prevent, Div Diabet Translat, Vis Hlth Initiat, Atlanta, GA 30341 USA. [Honeycutt, Amanda A.] Res Triangle Inst Int, Res Triangle Pk, SC USA. [Klein, Ron] Univ Wisconsin, Sch Med, Dept Ophthalmol & Visual Sci, Madison, WI 53706 USA. RP Saaddine, JB (reprint author), Ctr Dis Control & Prevent, Div Diabet Translat, Vis Hlth Initiat, 4770 Buford Hwy,Mail Stop K10, Atlanta, GA 30341 USA. EM jsaaddine@cdc.gov RI Narayan, K.M. Venkat /J-9819-2012 OI Narayan, K.M. Venkat /0000-0001-8621-5405 NR 31 TC 135 Z9 141 U1 0 U2 9 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0003-9950 J9 ARCH OPHTHALMOL-CHIC JI Arch. Ophthalmol. PD DEC PY 2008 VL 126 IS 12 BP 1740 EP 1747 DI 10.1001/archopht.126.12.1740 PG 8 WC Ophthalmology SC Ophthalmology GA 380RA UT WOS:000261481700018 PM 19064858 ER PT J AU Parner, ET Schendel, DE Thorsen, P AF Parner, Erik T. Schendel, Diana E. Thorsen, Poul TI Autism Prevalence Trends Over Time in Denmark Changes in Prevalence and Age at Diagnosis SO ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE LA English DT Article ID PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDERS; SPECIAL-EDUCATION; POPULATION; CALIFORNIA; MINNESOTA; CHILDREN AB Objective: To examine the effect of changing age at diagnosis on the diagnosed prevalence of autism among different birth cohorts. Design: Population-based cohort study. Setting: Children were identified in the Danish Medical Birth Registry and psychiatric outcomes were obtained via linkage with the Danish National Psychiatric Register. Participants: All children born in Denmark from January 1, 1994, through December 31, 1999 (N = 407 458). Main Outcome Measures: The age-specific prevalence, hazard ratio, and relative risk by age. Results: Statistically significant shifts in age at diagnosis were observed for autism spectrum disorder; children diagnosed before age 9 years in the cohorts born between January 1, 1994, and December 31, 1995, between January 1, 1996, and December 31, 1997, and between January 1, 1998, and December 31, 1999, were on average diagnosed at ages 5.9 (95% confidence interval [CI], 5.8-6.0), 5.8 (95% CI, 5.7-5.9), and 5.3 (95% CI, 5.2-5.4) years, respectively. The relative risk comparing the 1996-1997 birth cohort with the 1994-1995 birth cohort at age 3 years was 1.20 (95% CI, 0.86-1.67), which decreased to 1.10 (95% CI, 1.00-1.20) at age 11 years. Similarly, the relative risk comparing the 1998-1999 birth cohort with the 1994-1995 birth cohort at age 3 years was 1.69 (95% CI, 1.24-2.31), which decreased to 1.23 (95% CI, 1.11-1.37) at age 11 years. Similar results were observed for childhood autism. Conclusions: Shifts in age at diagnosis inflated the observed prevalence of autism in young children in the more recent cohorts compared with the oldest cohort. This study supports the argument that the apparent increase in autism in recent years is at least in part attributable to decreases in the age at diagnosis over time. C1 [Parner, Erik T.] Univ Aarhus, Inst Publ Hlth, Dept Biostat, DK-8000 Aarhus, Denmark. [Parner, Erik T.; Thorsen, Poul] Univ Aarhus, Inst Publ Hlth, N Atlantic Neuro Epidemiol Alliances, Dept Epidemiol, DK-8000 Aarhus, Denmark. [Schendel, Diana E.] Emory Univ, Rollins Sch Publ Hlth, Natl Ctr Birth Defects & Dev Disabil, Ctr Dis Control & Prevent, Atlanta, GA 30322 USA. [Schendel, Diana E.] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA. RP Parner, ET (reprint author), Univ Aarhus, Inst Publ Hlth, Dept Biostat, Vennelyst Blvd 6, DK-8000 Aarhus, Denmark. EM parner@biostat.au.dk RI Parner, Erik/F-5532-2010 NR 24 TC 52 Z9 55 U1 1 U2 7 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 1072-4710 J9 ARCH PEDIAT ADOL MED JI Arch. Pediatr. Adolesc. Med. PD DEC PY 2008 VL 162 IS 12 BP 1150 EP 1156 DI 10.1001/archpedi.162.12.1150 PG 7 WC Pediatrics SC Pediatrics GA 377XS UT WOS:000261286300006 PM 19047542 ER PT J AU Greenburg, DL Rusiecki, J Koutros, S Dosemeci, M Patel, R Hines, CJ Hoppin, JA Alavanja, MCR AF Greenburg, David L. Rusiecki, Jennifer Koutros, Stella Dosemeci, Mustafa Patel, Rahulkumar Hines, Cynthia J. Hoppin, Jane A. Alavanja, Michael C. R. TI Cancer incidence among pesticide applicators exposed to captan in the Agricultural Health Study SO CANCER CAUSES & CONTROL LA English DT Article DE Captan; Cancer; Agricultural Health Study; Cohort; Prospective; Pesticide; Fungicide; CAS number 133-06-2 ID FUNGICIDES CAPTAN; DNA-DAMAGE; MUTAGENICITY; URINE; ASSAY; RAT AB Objective Captan is a widely used antifungal pesticide whose potential to cause cancer in humans is uncertain. Methods We evaluated the incidence of cancer among pesticide applicators exposed to captan in the Agricultural Health Study. Detailed information on pesticide exposure and lifestyle factors was obtained from self-administered enrollment questionnaires completed between 1993 and 1997. Results Of the 48,986 applicators enrolled 4,383 (9%) had applied captan. Median follow-up time was 9.14 years. Poisson regression analysis was used to estimate relative risks (RR) for cancer subtypes by tertiles of captan exposure. We investigated risk for all cancers combined and sites of cancer for which at least 15 cases occurred among captan-exposed applicators. These sites included cancers of the prostate, lung, and colon, blood-related cancers, and colorectal cancers. During follow-up 2,912 incident primary cases of cancer were identified. No association between the highest tertile of captan exposure (>67.375 intensity-weighted days) and development of all cancers (RR = 0.89; 95% CI, 0.71-1.13) or cancer of any specific site was observed. Conclusion Although our study is limited by low numbers of observed cancer cases and follow-up time of 9.14 years, it does not provide evidence of an increased risk for the development of cancer at the investigated sites. C1 [Greenburg, David L.; Rusiecki, Jennifer; Patel, Rahulkumar] Uniformed Serv Univ Hlth Sci, Dept Med, EDP, Bethesda, MD 20814 USA. [Rusiecki, Jennifer; Koutros, Stella; Dosemeci, Mustafa; Alavanja, Michael C. R.] NCI, NIH, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, Rockville, MD USA. [Hines, Cynthia J.] NIOSH, Cincinnati, OH 45226 USA. [Hoppin, Jane A.] NIEHS, NIH, Epidemiol Branch, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA. RP Rusiecki, J (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, EDP, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM jrusiecki@usuhs.mil FU National Institutes of Health; National Institute of Environmental Health Sciences; National Cancer Institute FX This work was supported by the intramural research program of the National Institutes of Health, the National Institute of Environmental Health Sciences, and National Cancer Institute. NR 32 TC 13 Z9 16 U1 1 U2 6 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0957-5243 J9 CANCER CAUSE CONTROL JI Cancer Causes Control PD DEC PY 2008 VL 19 IS 10 BP 1401 EP 1407 DI 10.1007/s10552-008-9187-9 PG 7 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 370MM UT WOS:000260766300042 PM 18587656 ER PT J AU Ding, YS Zhang, LQ Jain, RB Jain, N Wang, RY Ashley, DL Watson, CH AF Ding, Yan S. Zhang, Liqin Jain, Ram B. Jain, Ntasha Wang, Richard Y. Ashley, David L. Watson, Clifford H. TI Levels of Tobacco-Specific Nitrosamines and Polycyclic Aromatic Hydrocarbons in Mainstream Smoke from Different Tobacco Varieties SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Article ID US-BRAND CIGARETTES; PREDICTING RELATIONSHIPS; NITRATE; CARCINOGEN; ORIGIN AB It has been estimated that one in every five cancer deaths worldwide are related to tobacco use. According to the IARC, 10 polycyclic aromatic hydrocarbons (PAH) and 8 tobacco-specific nitrosamines (TSNA), as well as at least 45 other compounds or substances found in tobacco smoke, are potential human carcinogens. The levels of these carcinogens in contents of tobacco and smoke emissions vary between different tobacco products. We evaluated mainstream smoke emissions from cigarettes made with different types of tobacco to examine the relation between their deliveries of TSNAs and PAHs and any possible influence from tobacco nitrate content. To investigate the contribution of tobacco content to mainstream cigarette smoke deliveries without confounders such as filter design, filter ventilation, and paper porosity, we used custom-made, research-grade, unfiltered cigarettes that contained bright, burley, oriental, reconstituted, or mixtures of these tobaccos. Our findings confirm results from other researchers that tobacco type can influence the mainstream smoke delivery of nicotine, TSNAs, and PAHs. However, we found that the effect varies among individual compounds. In addition, we observed a statistically significant relationship between nitrate content and mainstream smoke 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK); nitrate level also influenced the mainstream smoke deliveries of the summed total of the 10 PAHs identified by IARC as potential human carcinogens. The influence of nitrate on mainstream smoke NNK and PAH levels were of different magnitude and direction. Our results tend to indicate an inverse relation exists between NNK and PAH deliveries when considering different tobacco blends. (Cancer Epidemiol Biomarkers Prev 2008; 17(12):3366-71) C1 [Ding, Yan S.; Zhang, Liqin; Jain, Ram B.; Jain, Ntasha; Wang, Richard Y.; Ashley, David L.; Watson, Clifford H.] Natl Ctr Environm Hlth, Emergency Response & Air Toxicants Branch, Div Sci Lab, Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. RP Ding, YS (reprint author), Natl Ctr Environm Hlth, Emergency Response & Air Toxicants Branch, Div Sci Lab, Ctr Dis Control & Prevent, 4770 Buford Highway NE,Mailstop F-47, Atlanta, GA 30341 USA. EM yding@cdc.gov NR 26 TC 40 Z9 42 U1 1 U2 16 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1055-9965 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD DEC PY 2008 VL 17 IS 12 BP 3366 EP 3371 DI 10.1158/1055-9965.EPI-08-0320 PG 6 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 384DH UT WOS:000261724000013 PM 19064552 ER PT J AU Strickland, MJ Riehle-Colarusso, TJ Jacobs, JP Reller, MD Mahle, WT Botto, LD Tolbert, PE Jacobs, ML Lacour-Gayet, FG Tchervenkov, CI Mavroudis, C Correa, A AF Strickland, Matthew J. Riehle-Colarusso, Tiffany J. Jacobs, Jeffrey P. Reller, Mark D. Mahle, William T. Botto, Lorenzo D. Tolbert, Paige E. Jacobs, Marshall L. Lacour-Gayet, Francois G. Tchervenkov, Christo I. Mavroudis, Constantine Correa, Adolfo TI The importance of nomenclature for congenital cardiac disease: implications for research and evaluation SO CARDIOLOGY IN THE YOUNG LA English DT Article DE Tetralogy of Fallot; transposition of the arteries; hypoplastic left heart syndrome ID FUNCTIONALLY UNIVENTRICULAR HEART; OUTLET RIGHT VENTRICLE; SURGEONS PERFORMANCE; HETEROTAXY SYNDROME; MORTALITY-RATES; DATABASE; DEFECTS; CLASSIFICATION; CHILDREN; SOCIETY AB Background: Administrative databases are often used for congenital cardiac disease research and evaluation, with little validation of the accuracy of the diagnostic codes. Methods: Metropolitan Atlanta Congenital Defects Program surveillance records were reviewed and classified using a version of the International Pediatric and Congenital Cardiac Code. Using this clinical nomenclature as the referent, we report the sensitivity and false positive fraction (1 - positive predictive value) of the International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis codes for tetralogy of Fallot, transposition of the great arteries, and hypoplastic left heart syndrome. Results: We identified 4918 infants and foetuses with congenital cardiac disease from the surveillance records. Using only the International Classification of Diseases diagnosis codes, there were 280 records with tetralogy, 317 records with transposition, and 192 records with hypoplastic left heart syndrome. Based on the International Pediatric and Congenital Cardiac Code, 330 records were classified as tetralogy, 163 records as transposition, and 179 records as hypoplastic left heart syndrome. The sensitivity of International Classification of Diseases diagnosis codes was 83% for tetralogy, 100% for transposition, and 95% for hypoplastic left heart syndrome. The false positive fraction was 2% for tetralogy, 49% for transposition, and 1196 for hypoplastic left heart syndrome. Conclusions: Analyses based on International Classification of Diseases diagnosis codes may have substantial misclassification of congenital heart disease. Isolating the major defect is difficult, and certain codes do not differentiate between variants that are clinically and developmentally different. C1 [Strickland, Matthew J.; Riehle-Colarusso, Tiffany J.; Correa, Adolfo] US Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Strickland, Matthew J.; Tolbert, Paige E.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Jacobs, Jeffrey P.] Univ S Florida, All Childrens Hosp, Div Thorac & Cardiovasc Surg, CHIF,CSA,Coll Med, St Petersburg, FL 33701 USA. [Jacobs, Jeffrey P.] Univ S Florida, All Childrens Hosp, Div Thorac & Cardiovasc Surg, CHIF,CSA,Coll Med, Tampa, FL USA. [Jacobs, Jeffrey P.] Univ S Florida, Coll Med, Childrens Hosp Tampa, CSA, St Petersburg, FL 33701 USA. [Jacobs, Jeffrey P.] Univ S Florida, Coll Med, Childrens Hosp Tampa, CSA, Tampa, FL USA. [Reller, Mark D.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Botto, Lorenzo D.] Univ Utah, Dept Pediat, Salt Lake City, UT USA. [Jacobs, Marshall L.] Drexel Univ, St Christophers Hosp Children, Philadelphia, PA 19104 USA. [Lacour-Gayet, Francois G.] Univ Colorado, Denver Childrens Hosp, Denver, CO 80202 USA. [Tchervenkov, Christo I.] McGill Univ, Montreal Childrens Hosp, Montreal, PQ H3H 1P3, Canada. [Mavroudis, Constantine] Northwestern Univ, Childrens Mem Hosp, Chicago, IL 60614 USA. RP Strickland, MJ (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop E-86, Atlanta, GA 30333 USA. EM MStrickland@cdc.gov RI Tolbert, Paige/A-5676-2015 FU The Children's Heart Foundation FX We thank The Children's Heart Foundation (http://www.childrensheartfoundation.org/) for financial Support for the publication of this research. We also thank the Saint Joseph's Children's Hospital of Tampa and Michael D. Aubin, their Administrator and Chief Operating Officer, for financial and intellectual support of this research. NR 37 TC 64 Z9 66 U1 0 U2 1 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 1047-9511 J9 CARDIOL YOUNG JI Cardiol. Young PD DEC PY 2008 VL 18 SU 2 BP 92 EP 100 DI 10.1017/S1047951108002515 PG 9 WC Cardiac & Cardiovascular Systems; Pediatrics SC Cardiovascular System & Cardiology; Pediatrics GA 450DN UT WOS:000266381300006 PM 19063779 ER PT J AU Ford, ES Li, C Pearson, WS Zhao, G Strine, TW Mokdad, AH AF Ford, E. S. Li, C. Pearson, W. S. Zhao, G. Strine, T. W. Mokdad, A. H. TI Body mass index and headaches: findings from a national sample of US adults SO CEPHALALGIA LA English DT Article DE Body mass index; C-reactive protein; epidemiology; headache; migraine ID OBSTRUCTIVE SLEEP-APNEA; GENE-RELATED PEPTIDE; MIGRAINE HEADACHE; CLUSTER HEADACHE; OBESITY; EPIDEMIOLOGY; INFLAMMATION; DEPRESSION; DISABILITY AB The objective was to study the cross-sectional association between body mass index (BMI) and the prevalence of severe headaches or migraines in a national sample of US adults. We used data from 7601 men and women aged >= 20 years who participated in the National Health and Nutrition Examination Survey 1999-2002. The age-adjusted prevalence of severe headaches or migraines during the previous 3 months was 34.0, 18.9, 20.7 and 25.9% among participants with a BMI < 18.5, 18.5 to < 25, 25 to < 30 and >= 30 kg/m(2), respectively. After adjusting for a variety of covariates in a logistic regression model, those with a BMI < 18.5 kg/m(2) [odds ratio (OR) 2.01; 95% confidence interval (CI) 1.34, 3.02] or >= 30 kg/m(2) (OR 1.37; 95% CI 1.09, 1.72) had a significantly elevated OR for having a headache compared with participants with a BMI of 18.5-< 25 kg/m(2). BMI is associated with the prevalence of severe headaches or migraines in a non-linear manner. C1 [Ford, E. S.; Li, C.; Pearson, W. S.; Zhao, G.; Strine, T. W.; Mokdad, A. H.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Ford, ES (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway,MS K66, Atlanta, GA 30341 USA. EM eford@cdc.gov NR 44 TC 53 Z9 54 U1 0 U2 1 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0333-1024 J9 CEPHALALGIA JI Cephalalgia PD DEC PY 2008 VL 28 IS 12 BP 1270 EP 1276 DI 10.1111/j.1468-2982.2008.01671.x PG 7 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 375UJ UT WOS:000261138600005 PM 18727641 ER PT J AU Porter, EN Li, Z Romanoff, LC Trinidad, DA Sjodin, A AF Porter, Erin N. Li, Zheng Romanoff, Lovisa C. Trinidad, Debra A. Sjodin, Andreas TI Variability in Levels of Urinary Hydroxylated Polycyclic Aromatic Hydrocarbon Metabolites SO CHEMICAL RESEARCH IN TOXICOLOGY LA English DT Meeting Abstract CT 236th National Meeting of the Division of Chemical Toxicology of the American-Chemical-Society CY AUG 17-21, 2008 CL Philadelphia, PA SP Amer Chem Soc, Div Chem Toxicol C1 [Porter, Erin N.; Li, Zheng; Romanoff, Lovisa C.; Trinidad, Debra A.; Sjodin, Andreas] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. RI Sjodin, Andreas/F-2464-2010 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0893-228X J9 CHEM RES TOXICOL JI Chem. Res. Toxicol. PD DEC PY 2008 VL 21 IS 12 MA 86 BP 2449 EP 2450 PG 2 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology SC Pharmacology & Pharmacy; Chemistry; Toxicology GA 384HU UT WOS:000261736700104 ER PT J AU Ledue, TB Collins, MF Young, J Schriefer, ME AF Ledue, Thomas B. Collins, Marilyn F. Young, John Schriefer, Martin E. TI Evaluation of the Recombinant VlsE-Based Liaison Chemiluminescence Immunoassay for Detection of Borrelia burgdorferi and Diagnosis of Lyme Disease SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID LINKED-IMMUNOSORBENT-ASSAY; PROFICIENCY TESTING PROGRAM; VARIABLE SURFACE-ANTIGEN; IXODES-RICINUS TICKS; ANTIBODY-RESPONSE; SENSU-LATO; TREATED PATIENTS; LABORATORY EVALUATION; ANTIBIOTIC-TREATMENT; SEROLOGIC DIAGNOSIS AB Recent efforts to improve the serologic diagnosis of Lyme disease have included the use of a synthetic peptide (C6) that reproduces the sequence of invariable region 6 of VlsE, the variable surface antigen of Borrelia burgdorferi. In the present study, the diagnostic performance of DiaSorin's recombinant VlsE-based chemiluminescence immunoassay in 1,947 human serum samples was evaluated. Sensitivity was determined using two serum panels from the CDC. For panel I, we observed sensitivities of 68.4% and 75.6% for subjects with early, localized (n = 19) or disseminated (n = 41) disease, respectively. For panel II, we observed sensitivities of 61.5% and 100% for subjects with early (n = 26) or late-stage (n = 11) disease, respectively. We observed a specificity of 99.5% for healthy donors (n = 600) living either in regions of the United States where the disease is endemic or in regions where it is not endemic. Overall, specificity among 207 potentially cross-reactive sera from subjects who had other spirochetal infections, nonspirochetal infections including bacterial and viral infections, or autoimmune or neurologic disease; who were positive for rheumatoid factor or anti-mouse antibodies; or who had been previously vaccinated for Lyme disease was 93.7%. In a direct comparison of 1,038 prospectively collected samples for Lyme disease testing we observed a relative sensitivity of 70%, a relative specificity of 99.1%, and an overall agreement of 97.1% between the DiaSorin recombinant VlsE chemiluminescence immunoassay and the Immunetics peptide-based C6 enzyme-linked immunosorbent assay. C1 [Ledue, Thomas B.; Collins, Marilyn F.] Fdn Blood Res, Scarborough, ME 04074 USA. [Young, John; Schriefer, Martin E.] Ctr Dis Control & Prevent, Diagnost & Reference Sect, Div Vector Borne Infect Dis, Ft Collins, CO USA. RP Ledue, TB (reprint author), Fdn Blood Res, 8 Sci Pk Rd, Scarborough, ME 04074 USA. EM tledue@fbr.org NR 65 TC 16 Z9 17 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD DEC PY 2008 VL 15 IS 12 BP 1796 EP 1804 DI 10.1128/CVI.00195-08 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 379GN UT WOS:000261384800008 PM 18945880 ER PT J AU Gershman, MD Kennedy, DJ Noble-Wang, J Kim, C Gullion, J Kacica, M Jensen, B Pascoe, N Saiman, L McHale, J Wilkins, M Schoonmaker-Bopp, D Clayton, J Arduino, M Srinivasan, A AF Gershman, Mark D. Kennedy, Donald J. Noble-Wang, Judith Kim, Curi Gullion, Jessica Kacica, Marilyn Jensen, Bette Pascoe, Neil Saiman, Lisa McHale, Jean Wilkins, Melinda Schoonmaker-Bopp, Dianna Clayton, Joshua Arduino, Matthew Srinivasan, Arjun CA Pseudomonas Fluorescens Invest TI Multistate Outbreak of Pseudomonas fluorescens Bloodstream Infection after Exposure to Contaminated Heparinized Saline Flush Prepared by a Compounding Pharmacy SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID TRANSFUSION; BIOFILMS AB Background. Pharmaceutical compounding, the manipulation of ingredients to create a customized medication, is a widespread practice. In January 2005, the Centers for Disease Control and Prevention was notified of 4 cases of Pseudomonas fluorescens bacteremia that were traced to contaminated heparinized saline intravenous flush syringes prepared as a compounded medical product. Patients and Methods. We reviewed medical records of symptomatic patients with P. fluorescens-positive cultures of blood specimens or sections of explanted catheters, reviewed the production process of syringes, performed syringe cultures, compared isolates by pulsed-field gel electrophoresis (PFGE), and examined catheters by scanning electron microscopy. Results. We identified 80 patients in 6 states with P. fluorescens-positive cultures during December 2004-March 2006. Sixty-four patients (80%) had received a diagnosis of cancer. Seventy-four (99%) of 75 patients for whom information about catheter type was available had long-term indwelling catheters. Thirty-three (41%) of 80 cases were diagnosed 84-421 days after the patient's last potential exposure to a contaminated flush (delayed-onset cases). Compared with patients with early infection onset, more patients with delayed infection onset had venous ports (100% versus 50%;). By PFGE, clinical isolates from 50 (98%) of 51 patients were related to isolates P < .001 cultured from unopened syringes. Scanning electron microscopy of explanted catheters revealed biofilms containing organisms morphologically consistent with P. fluorescens. Conclusion. This outbreak underscores important challenges in ensuring the safety of compounded pharmaceuticals and demonstrates the potential for substantially delayed infections after exposures to contaminated infusates. Exposures to compounded products should be considered when investigating outbreaks. Patients exposed to contaminated infusates require careful follow-up, because infections can occur long after exposure. C1 [Gershman, Mark D.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Michigan Dept Community Health, Atlanta, GA 30333 USA. [Noble-Wang, Judith; Jensen, Bette; Arduino, Matthew] Ctr Dis Control & Prevent, Clin & Environm Microbiol Branch, Atlanta, GA USA. [Srinivasan, Arjun] Ctr Dis Control & Prevent, Response Team, Div Healthcare Qual Promot, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA USA. [Kennedy, Donald J.] St Louis Univ, Sch Med, Div Infect Dis & Immunol, St Louis, MO USA. [Kim, Curi] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA. [Wilkins, Melinda] Michigan Dept Community Hlth, Div Communicable Dis, Lansing, MI USA. [Gullion, Jessica] Denton Cty Hlth Dept, Denton, TX USA. [Pascoe, Neil] Texas Dept State Hlth Serv, Austin, TX USA. [Kacica, Marilyn; Schoonmaker-Bopp, Dianna] New York State Dept Hlth, Albany, NY 12237 USA. [Saiman, Lisa] Columbia Univ, Sch Med, Dept Pediat, New York, NY USA. [McHale, Jean] McHale Inst, Sioux Falls, SD USA. [Clayton, Joshua] S Dakota Dept Hlth, Pierre, SD USA. RP Gershman, MD (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv, Michigan Dept Community Health, 1600 Clifton Rd,MS E-03, Atlanta, GA 30333 USA. EM mgershman@cdc.gov RI Arduino, Matthew/C-1461-2012 OI Arduino, Matthew/0000-0001-7072-538X FU US Department of Health and Human Services FX US Department of Health and Human Services and state and local health departments. NR 18 TC 45 Z9 46 U1 2 U2 8 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD DEC 1 PY 2008 VL 47 IS 11 BP 1372 EP 1379 DI 10.1086/592968 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 369UT UT WOS:000260720100002 PM 18937575 ER PT J AU Ferdinands, JM Mannino, DM AF Ferdinands, Jill M. Mannino, David M. TI Obstructive Lung Disease Models: What Is Valid? SO COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE LA English DT Review DE Chronic obstructive lung disease; Asthma; Natural history; Model; Validation ID COST-EFFECTIVENESS; PULMONARY-DISEASE; INHALED CORTICOSTEROIDS; ECONOMIC-MODEL; ASTHMA; IMPACT; INTERVENTIONS; SMOKING; COPD AB Use of disease simulation models has led to scrutiny of model methods and demand for evidence that models credibly simulate health outcomes. We sought to describe recent obstructive lung disease simulation models and their validation. Medline and EMBASE were used to identify obstructive lung disease simulation models published from January 2000 to June 2006. Publications were reviewed to assess model attributes and four types of validation: first-order (verification/debugging), second-order (comparison with studies used in model development), third-order (comparison with studies not used in model development), and predictive validity. Six asthma and seven chronic obstructive pulmonary disease models were identified. Seven (54%) models included second-order validation, typically by comparing observed outcomes to simulations of source study cohorts. Seven (54%) models included third-order validation, in which modeled outcomes were usually compared qualitatively for agreement with studies independent of the model. Validation endpoints included disease prevalence, exacerbation, and all-cause mortality. Validation was typically described as acceptable, despite near-universal absence of criteria for judging adequacy of validation. Although over half of recent obstructive lung disease simulation models report validation, inconsistencies in validation methods and lack of detailed reporting make assessing adequacy of validation difficult. For simulation modeling to be accepted as a tool for evaluating clinical and public health programs, models must be validated to credibly simulate health outcomes of interest. Defining the required level of validation and providing guidance for quantitative assessment and reporting of validation are important future steps in promoting simulation models as practical decision tools. C1 [Ferdinands, Jill M.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA. [Mannino, David M.] Univ Kentucky, Coll Med, Div Pulm & Crit Care Med, Lexington, KY USA. RP Ferdinands, JM (reprint author), Ctr Dis Control & Prevent, Influenza Div, 1600 Clifton Rd,MS A-32, Atlanta, GA 30333 USA. EM zdn5@cdc.gov; Dmannino@uky.edu OI Mannino, David/0000-0003-3646-7828 NR 24 TC 5 Z9 5 U1 0 U2 5 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1541-2555 J9 COPD JI COPD-J. Chronic Obstr. Pulm. Dis. PD DEC PY 2008 VL 5 IS 6 BP 382 EP 393 DI 10.1080/15412550802522304 PG 12 WC Respiratory System SC Respiratory System GA 428HA UT WOS:000264837400008 PM 19353353 ER PT J AU Atrash, H Jack, BW Johnson, K AF Atrash, Hani Jack, Brian W. Johnson, Kay TI Preconception care: a 2008 update SO CURRENT OPINION IN OBSTETRICS & GYNECOLOGY LA English DT Article DE infant; perinatal; preconception; pregnancy; women ID CORONARY-HEART-DISEASE; WOMENS HEALTH-CARE; UNITED-STATES; ADULT LIFE; PREGNANCY; PROMOTION; PREVALENCE; CHILDHOOD; PROVIDER; OUTCOMES AB Purpose of review This study reviews what we know about preconception care, its definition, goals, and content; the science behind the recommended interventions; opportunities for implementing preconception care; and the challenges facing its implementation. Recent findings There is solid scientific evidence that many interventions will improve pregnancy outcomes if delivered before pregnancy or early in pregnancy. Experts continue to explore the most effective means for implementing preconception care, taking into consideration issues related to policy, finance, public health practice, research/surveillance, and consumer and provider education. Summary Over the past 4 years, there has been renewed interest and a great emphasis on preconception health and healthcare as alternative and additional approaches to counter the persistent increasing incidence in adverse pregnancy outcomes in the United States. Following the publication of the 'Recommendations to Improve Preconception Health and Healthcare' in 2006, many state and local health departments initiated programs to implement the recommendations. Several countries such as Canada, Belgium, and the Netherlands have also started to implement preconception care programs. There are many opportunities for promoting preconception health and providing preconception care; however, making preconception care a standard practice continues to face many barriers. C1 [Atrash, Hani] CDC, NCBDDD, Atlanta, GA 30333 USA. [Jack, Brian W.] Boston Univ, Sch Med, Dept Family Med, Boston, MA 02118 USA. [Johnson, Kay] Dartmouth Med Sch, Dept Pediat, Lebanon, NH USA. RP Atrash, H (reprint author), CDC, NCBDDD, 1600 Clifton Rd,NE MS-E87, Atlanta, GA 30333 USA. EM hatrash@cdc.gov OI Jack, Brian/0000-0002-6497-2437 NR 75 TC 29 Z9 32 U1 3 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1040-872X J9 CURR OPIN OBSTET GYN JI Curr. Opin. Obstet. Gynecol. PD DEC PY 2008 VL 20 IS 6 BP 581 EP 589 DI 10.1097/GCO.0b013e328317a27c PG 9 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 394DR UT WOS:000262426300012 PM 18989135 ER PT J AU Lawrence, JM Liese, AD Liu, L Dabelea, D Anderson, A Imperatore, G Bell, R AF Lawrence, Jean M. Liese, Angela D. Liu, Lenna Dabelea, Dana Anderson, Andrea Imperatore, Giuseppina Bell, Ronny TI Weight-Loss Practices and Weight-Related Issues Among Youth With Type 1 or Type 2 Diabetes SO DIABETES CARE LA English DT Article ID EATING-DISORDERS; ADOLESCENT FEMALES; UNITED-STATES; MELLITUS; CHILDREN; PREVALENCE; OBESITY; SEARCH; EPIDEMIOLOGY; PREVENTION AB OBJECTIVE - The purpose of this study was to describe the weight-loss practices and Weight-related issues reported by youth with diabetes, according to sex and diabetes type. RESEARCH DESIGN AND METHODS - A total of 1,742 female and 1,615 Male youth aged 10-21 years with type 1. or type 2 diabetes completed a SEARCH for Diabetes in Youth study Visit during which height, weight, and AlC were measured. A survey assessed Weight-related issues and weight-loss practices. RESULTS - Although more common in youth with type 2 diabetes, youth with type 1, diabetes also reported weight-related concerns and had elevated BMI. Among youth who had ever tried to lose weight (n = 1,646), healthy weight-loss practices (diet [76.5%] and exercise [94.8%]) were the most common, whereas unhealthy practices (fasting [8.6%], using diet aids [7.5%], Vomiting or laxative use [2.3%], and skipping insulin closes [4.2%]) were less common. In sex-specific multivariable models including age, race/ethnicity, diabetes type, BMI category, and glycemic control, obese females and overweight/obese males were more likely to report ever practicing any unhealthy weight-loss practice than normal-weight youth. These practices were associated with poor glycemic control for female but not male subjects. All unhealthy weight-loss practices except fasting were more common in female than in male subjects. Dieting, fasting, and using diet aids were all more common in youth with type 2 diabetes than in those with type 1 diabetes. CONCLUSION - Given the prevalence of over-weight and obesity among youth with type 1. or type 2 diabetes, health care professionals caring for youth with diabetes need to pay particular attention to identifying youth, particularly females, with unhealthy weight-loss practices. C1 [Lawrence, Jean M.] Kaiser Permanente So Calif, Dept Res & Evaluat, Pasadena, CA USA. [Liese, Angela D.] Univ S Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA. [Liese, Angela D.] Univ S Carolina, Arnold Sch Publ Hlth, Ctr Res Nutr & Hlth Dispar, Columbia, SC 29208 USA. [Liu, Lenna] Childrens Hosp & Reg Med Ctr, Seattle, WA USA. [Dabelea, Dana] Univ Colorado, Colorado Sch Publ Hlth, Dept Epidemiol, Denver, CO 80202 USA. [Anderson, Andrea; Bell, Ronny] Wake Forest Univ, Bowman Gray Sch Med, Dept Publ Hlth Sci, Winston Salem, NC 27103 USA. [Imperatore, Giuseppina] Ctr Dis Control & Prevent, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Lawrence, JM (reprint author), Kaiser Permanente So Calif, Dept Res & Evaluat, Pasadena, CA USA. EM jean.m.lawrence@kp.org FU Centers for Disease Control and Prevention [PA 00097, DP-05-069]; National Institutes of Health; Kaiser Permanente Southern California [U01 DP000246]; University Of Colorado Health Sciences Center [U01 DP000247]; Pacific Health Research Institute [U01 DP000245]; Children's Hospital Medical Center (Cincinnati) [U01 DP000248]; University of South Carolina [U01 DP000254]; University of Washington School of Medicine [U01 DP000244]; Wake Forest University School of Medicine [U01 DP000250] FX Preliminary results of this study were presented in poster format at the 66th annual meeting of the American Diabetes Association, Washington, DC, 9-13 June, 2006. NR 25 TC 18 Z9 18 U1 1 U2 8 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 J9 DIABETES CARE JI Diabetes Care PD DEC PY 2008 VL 31 IS 12 BP 2251 EP 2257 DI 10.2337/dc08-0719 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 381RB UT WOS:000261552500004 PM 18809623 ER PT J AU Hageman, JC Patel, J Franklin, P Miscavish, K McDougal, L Lonsway, D Khan, FN AF Hageman, Jeffrey C. Patel, Jean Franklin, Patrick Miscavish, Karen McDougal, Linda Lonsway, David Khan, Fazle N. TI Occurrence of a USA300 vancomycin-intermediate Staphylococcus aureus SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE LA English DT Article DE Staphylococcus aureus; Vancomycin; VISA ID REDUCED SUSCEPTIBILITY; UNITED-STATES; INFECTIONS; DAPTOMYCIN; STRAIN AB A vancomycin-intermediate Staphylococcus aureus (VISA) isolated from the blood of a 46-year-old patient with endocarditis was determined to be pulsed-field type USA300, daptomycin nonsusceptible, and positive for the Panton-Valentine leukocidin genes. Development of the VISA phenotype does not appear limited to traditional health care strains of S. aureus. (C) 2008 Elsevier Inc. All rights reserved. C1 [Hageman, Jeffrey C.; Patel, Jean; McDougal, Linda; Lonsway, David] Ctr Dis Control & Prevent, Atlanta, GA 30033 USA. [Franklin, Patrick; Khan, Fazle N.] Missouri Dept Hlth & Senior Serv, Jefferson City, MO USA. [Miscavish, Karen] Kansas City Hlth Dept, Kansas City, MO USA. RP Hageman, JC (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30033 USA. EM jhageman@cdc.gov NR 12 TC 23 Z9 24 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0732-8893 J9 DIAGN MICR INFEC DIS JI Diagn. Microbiol. Infect. Dis. PD DEC PY 2008 VL 62 IS 4 BP 440 EP 442 DI 10.1016/j.diagmicrobio.2008.08.005 PG 3 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA 381RR UT WOS:000261554100016 PM 18842378 ER PT J AU Brunkard, J Namulanda, G Ratard, R AF Brunkard, Joan Namulanda, Gonza Ratard, Raoult TI Hurricane Katrina Deaths, Louisiana, 2005 SO DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS LA English DT Article DE Hurricane Katrina; Louisiana; mortality; drowning; flooding; disaster preparedness AB Objective: Hurricane Katrina struck the US Gulf Coast on August 29, 2005, causing unprecedented damage to numerous communities in Louisiana and Mississippi. Our objectives were to verify, document, and characterize Katrina-related mortality in Louisiana and help identify strategies to reduce mortality in future disasters. Methods: We assessed Hurricane Katrina mortality data sources received in 2007, including Louisiana and out-of-state death certificates for deaths occurring from August 27 to October 31, 2005, and the Disaster Mortuary Operational Response Team's confirmed victims' database. We calculated age-, race-, and sex-specific mortality rates for Orleans, St Bernard, and Jefferson Parishes, where 95% of Katrina victims resided and conducted stratified analyses by parish of residence to compare differences between observed proportions of victim demographic characteristics and expected values based on 2000 US Census data, using Pearson chi square and Fisher exact tests. Results: We identified 971 Katrina-related deaths in Louisiana and 15 deaths among Katrina evacuees in other states. Drowning (40%), injury and trauma (25%), and heart conditions (11%) were the major causes of death among Louisiana victims. Forty-nine percent of victims were people 75 years old and older. Fifty-three percent of victims were men; 51% were black; and 42% were white. In Orleans Parish, the mortality rate among blacks was 1.7 to 4 times higher than that among whites for all people 18 years old and older. People 75 years old and older were significantly more likely to be storm victims (P < .0001). Conclusions: Hurricane Katrina was the deadliest hurricane to strike the US Gulf Coast since 1928. Drowning was the major cause of death and people 75 years old and older were the most affected population cohort. Future disaster preparedness efforts must focus on evacuating and caring for vulnerable populations, including those in hospitals, long-term care facilities, and personal residences. Improving mortality reporting timeliness will enable response teams to provide appropriate interventions to these populations and to prepare and implement preventive measures before the next disaster. (Disaster Med Public Health Preparedness. 2008; 2: 215-223) C1 [Brunkard, Joan; Namulanda, Gonza] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Ratard, Raoult] Louisiana Off Publ Hlth, Baton Rouge, LA USA. RP Brunkard, J (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy NE,MS F-22, Atlanta, GA 30341 USA. EM jbrunkard@cdc.gov OI Brunkard, Joan/0000-0001-5270-2627 NR 10 TC 53 Z9 53 U1 6 U2 39 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 1935-7893 J9 DISASTER MED PUBLIC JI Dis. Med. Public Health Prep. PD DEC PY 2008 VL 2 IS 4 BP 215 EP 223 DI 10.1097/DMP.0b013e31818aaf55 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA V11GZ UT WOS:000207521400004 PM 18756175 ER PT J AU Barter, ZE Chowdry, JE Harlow, JR Snawder, JE Lipscomb, JC Rostami-Hodjegan, A AF Barter, Z. E. Chowdry, J. E. Harlow, J. R. Snawder, J. E. Lipscomb, J. C. Rostami-Hodjegan, A. TI Covariation of Human Microsomal Protein Per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data Pooling SO DRUG METABOLISM AND DISPOSITION LA English DT Article ID VIVO METABOLIC-CLEARANCE; IN-VITRO DATA; DRUG-METABOLISM; RAT; INVITRO; CYTOCHROME-P-450; PREDICTION; GLUCURONIDATION; HOMOGENATE; IMIPRAMINE AB Scaling of metabolic clearance values from liver microsomal data or recombinantly expressed cytochrome P450 enzymes to predict human hepatic clearance requires knowledge of the amount of microsomal protein per gram of liver (MPPGL). Identification of physiological covariates of MPPGL requires analysis of values from large diverse populations, which necessitates pooling of data from numerous sources. To ensure compatibility between results obtained within and between studies, the impact of interoperator differences and sample storage on values of MPPGL was investigated. With use of triplicate samples from one liver (HL86), no statistically significant difference was detected between values of MPPGL prepared from samples stored at -80 degrees C ( 23.5 +/- 1.2 mg g(-1)) and those determined using fresh tissue ( 21.9 +/- 0.3 mg g(-1)). Although there was a significant difference in the yield of microsomal protein obtained from another liver sample ( HL43) by three different operators ( 17 +/- 1, 19 +/- 2, and 24 +/- 1 mg g(-1); p = 0.004, analysis of variance), no difference was observed in the estimated MPPGL after application of appropriate correction factors for each operator ( 28 +/- 1, 30 +/- 5, and 31 +/- 4 mg g(-1)). The result provided justification for pooling reported values of MPPGL for use in covariate analysis. Investigation of the relationship between age and MPPGL provided preliminary evidence that MPPGL values increase from birth to a maximum of 40 mg g(-1) [ 95% confidence interval for the geometric mean ( 95% CI mean(geo)): 37-43 mg g(-1)] at approximately 28 years followed by a gradual decrease in older age ( mean of 29 mg g(-1) at 65 years; 95% CI meangeo: 27-32 mg g(-1)). Accordingly, appropriate age-adjusted scaling factors should be used in extrapolating in vitro clearance values to clinical studies. C1 [Barter, Z. E.; Chowdry, J. E.; Harlow, J. R.; Rostami-Hodjegan, A.] Univ Sheffield, Royal Hallamshire Hosp, Acad Unit Clin Pharmacol, Sheffield S10 2JF, S Yorkshire, England. [Barter, Z. E.; Rostami-Hodjegan, A.] Simcyp Ltd, Sheffield, S Yorkshire, England. [Snawder, J. E.] NIOSH, US Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Lipscomb, J. C.] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Cincinnati, OH 45268 USA. RP Barter, ZE (reprint author), Univ Sheffield, Royal Hallamshire Hosp, Acad Unit Clin Pharmacol, Sheffield S10 2JF, S Yorkshire, England. FU Simcyp Ltd., (Sheffield, UK) FX Z.E.B. was supported by Simcyp Ltd., (Sheffield, UK) and European Union Framework 6 (BIOSIM). NR 21 TC 47 Z9 47 U1 2 U2 5 PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA SN 0090-9556 EI 1521-009X J9 DRUG METAB DISPOS JI Drug Metab. Dispos. PD DEC PY 2008 VL 36 IS 12 BP 2405 EP 2409 DI 10.1124/dmd.108.021311 PG 5 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 378SU UT WOS:000261345000001 PM 18775982 ER PT J AU Velasco-Villa, A Reeder, SA Orciari, LA Yager, PA Franka, R Blanton, JD Zuckero, L Hunt, P Oertli, EH Robinson, LE Rupprecht, CE AF Velasco-Villa, Andres Reeder, Serena A. Orciari, Lillian A. Yager, Pamela A. Franka, Richard Blanton, Jesse D. Zuckero, Letha Hunt, Patrick Oertli, Ernest H. Robinson, Laura E. Rupprecht, Charles E. TI Enzootic Rabies Elimination from Dogs and Reemergence in Wild Terrestrial Carnivores, United States SO EMERGING INFECTIOUS DISEASES LA English DT Article ID MOLECULAR EPIDEMIOLOGY; VIRUS VARIANTS; IDENTIFICATION; SEQUENCES; COYOTES; HISTORY; ONTARIO; AFRICA; MEXICO; HOST AB To provide molecular and virologic evidence that domestic dog rabies is no longer enzootic to the United States and to identify putative relatives of dog-related rabies viruses (RVs) circulating in other carnivores, we studied RVs associated with recent and historic dog rabies enzootics worldwide. Molecular, phylogenetic, and epizootiologic evidence shows that domestic dog rabies is no longer enzootic to the United States. Nonetheless, our data suggest that independent rabies enzootics are now established in wild terrestrial carnivores (skunks in California and north-central United States, gray foxes in Texas and Arizona, and mongooses in Puerto Rico), as a consequence of different spillover events from long-term rabies enzootics associated with dogs. These preliminary results highlight the key role of dog RVs and human-dog demographics as operative factors for host shifts and disease reemergence into other important carnivore populations and highlight the need for the elimination of dog-related RVs worldwide. C1 [Velasco-Villa, Andres; Reeder, Serena A.; Orciari, Lillian A.; Yager, Pamela A.; Franka, Richard; Blanton, Jesse D.; Rupprecht, Charles E.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Zuckero, Letha; Hunt, Patrick; Oertli, Ernest H.; Robinson, Laura E.] Texas Dept State Hlth Serv, Austin, TX USA. RP Velasco-Villa, A (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop G33, Atlanta, GA 30333 USA. EM dly3@cdc.gov NR 39 TC 43 Z9 45 U1 0 U2 15 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD DEC PY 2008 VL 14 IS 12 BP 1849 EP 1854 DI 10.3201/eid1412.080876 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 401AZ UT WOS:000262911800003 PM 19046506 ER PT J AU Zaidenstein, R Sadik, C Lerner, L Valinsky, L Kopelowitz, J Yishai, R Agmon, V Parsons, M Bopp, C Weinberger, M AF Zaidenstein, Ronit Sadik, Chantal Lerner, Larisa Valinsky, Lea Kopelowitz, June Yishai, Ruth Agmon, Vered Parsons, Michele Bopp, Cheryl Weinberger, Miriam TI Clinical Characteristics and Molecular Subtyping of Vibrio vulnificus Illnesses, Israel SO EMERGING INFECTIOUS DISEASES LA English DT Article ID FIELD GEL-ELECTROPHORESIS; UNITED-STATES; RAW OYSTERS; INFECTIONS; DISEASE; EPIDEMIOLOGY; BIOTYPE-3; TAIWAN; IDENTIFICATION; PATHOGENESIS AB During 1996-1997, a new Vibrio vulnificus biotype 3, which caused severe soft tissue infection after fishbone injury, emerged in Israel. We conducted a follow-up study from 1998 through 2005 to assess changing trends, outcomes, and molecular relatedness of the implicated strains. A total of 132 cases (71% confirmed and 29% suspected) of V vulnificus biotype 3 infection were found. Most infections (95%) were related to percutaneous fish exposure, mainly tilapia (83%) or common carp (13%). Bacteremia, altered immune status, and history of ischemic heart disease were identified as independent risk factors for death, which reached a prevalence of 7.6%. Pulsed-field gel electrophoresis patterns of strains from 1998 through 2005 and from 1996 through 1997 showed a high degree of homogeneity and were distinct from those of V vulnificus biotype 1. Infections caused by V vulnificus biotype 3 continue to affect the public's health in Israel. C1 [Weinberger, Miriam] Assaf Harofeh Med Ctr, Infect Dis Unit, IL-70300 Zerifin, Israel. [Sadik, Chantal; Lerner, Larisa; Valinsky, Lea; Kopelowitz, June; Yishai, Ruth; Agmon, Vered] Israel Minist Hlth, Jerusalem, Israel. [Parsons, Michele; Bopp, Cheryl] Ctr Dis Control & Prevent, Atlanta, GA USA. [Weinberger, Miriam] Tel Aviv Univ, Ramat Aviv, Israel. RP Weinberger, M (reprint author), Assaf Harofeh Med Ctr, Infect Dis Unit, IL-70300 Zerifin, Israel. EM miriw@netvision.net.il NR 38 TC 16 Z9 16 U1 0 U2 5 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD DEC PY 2008 VL 14 IS 12 BP 1875 EP 1882 DI 10.3201/eid1412.080499 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 401AZ UT WOS:000262911800007 PM 19046510 ER PT J AU Kulzmin, IV Niezgoda, M Franka, R Agwanda, B Markotter, W Beagley, JC Urazova, OY Breiman, RF Rupprecht, CE AF Kulzmin, Ivan V. Niezgoda, Michael Franka, Richard Agwanda, Bernard Markotter, Wanda Beagley, Janet C. Urazova, Olga Yu Breiman, Robert F. Rupprecht, Charles E. TI Possible Emergence of West Caucasian Bat Virus in Africa SO EMERGING INFECTIOUS DISEASES LA English DT Article ID NEW-MEXICO; RABIES; LYSSAVIRUSES AB The prevalence of neutralizing antibody against West Caucasian bat virus (WCBV) in Miniopterus bats collected in Kenya ranged from 17% to 26%. Seropositive bats were detected in 4 of 5 locations sampled across the country. These findings provide evidence that WCBV, originally isolated in Europe, may emerge in other continents. C1 [Kulzmin, Ivan V.; Niezgoda, Michael; Urazova, Olga Yu; Rupprecht, Charles E.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Agwanda, Bernard] Natl Museums Kenya, Nairobi, Kenya. [Markotter, Wanda] Univ Pretoria, ZA-0002 Pretoria, South Africa. [Beagley, Janet C.] Univ Georgia, Athens, GA 30602 USA. [Breiman, Robert F.] Ctr Dis Control & Prevent Kenya, Nairobi, Kenya. RP Kulzmin, IV (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop G33, Atlanta, GA 30333 USA. EM ikuzmin@cdc.gov RI Markotter, Wanda/A-2129-2010; OI Markotter, Wanda/0000-0002-7550-0080 FU Centers for Disease Control and Prevention in Atlanta.; National Research Foundation (South Africa) FX The study was supported in part by the Global Disease Detection program of the Centers for Disease Control and Prevention in Atlanta. J.C.B. received funds from the O.C. Hubert Fellowship (Atlanta); W.M. received funds from the National Research Foundation (South Africa). NR 15 TC 3 Z9 4 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD DEC PY 2008 VL 14 IS 12 BP 1887 EP 1889 DI 10.3201/eid1412.080750 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 401AZ UT WOS:000262911800009 PM 19046512 ER PT J AU Nava, S Elshenawy, Y Eremeeva, ME Sumner, JW Mastropaolo, M Paddock, CD AF Nava, Santiago Elshenawy, Yasmin Eremeeva, Marina E. Sumner, John W. Mastropaolo, Mariano Paddock, Christopher D. TI Rickettsia parkeri in Argentina SO EMERGING INFECTIOUS DISEASES LA English DT Article ID SPOTTED-FEVER; AMBLYOMMA-MACULATUM; TICKS ACARI; IXODIDAE; SEASONALITY; URUGUAY; BRAZIL; DELTA; HOSTS; KOCH AB Clinical reports of an eschar-associated rickettsiosis in the Parana River Delta of Argentina prompted an evaluation of Amblyomma triste ticks in this region. When evaluated by PCR, 17 (7.6%) of 223 questing adult A. triste ticks, collected from 2 sites in the lower Parana River Delta, contained DNA of Rickettsia parkeri. C1 [Elshenawy, Yasmin; Sumner, John W.; Mastropaolo, Mariano; Paddock, Christopher D.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Nava, Santiago; Mastropaolo, Mariano] Inst Nacl Tecnol Agropecuaria, Santa Fe, Argentina. RP Paddock, CD (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop G32, Atlanta, GA 30333 USA. EM cdp9@cdc.gov FU INTA; Asociacion Cooperadora INTA Rafaela; Consejo Nacional de Investigaciones Cientificas y Tecnicas FX INTA, Asociacion Cooperadora INTA Rafaela, and Consejo Nacional de Investigaciones Cientificas y Tecnicas provided support to S.N. and M.M. NR 15 TC 45 Z9 48 U1 0 U2 2 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD DEC PY 2008 VL 14 IS 12 BP 1894 EP 1897 DI 10.3201/eid1412.080860 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 401AZ UT WOS:000262911800011 PM 19046514 ER PT J AU Velasco-Villa, A Messenger, SL Orciari, LA Niezgoda, M Blanton, JD Fukagawa, C Rupprecht, CE AF Velasco-Villa, Andres Messenger, Sharon L. Orciari, Lillian A. Niezgoda, Michael Blanton, Jesse D. Fukagawa, Chris Rupprecht, Charles E. TI Identification of New Rabies Virus Variant in Mexican Immigrant SO EMERGING INFECTIOUS DISEASES LA English DT Article ID DIVERSITY; EPIDEMIOLOGY AB A novel rabies virus was identified after death in a man who had immigrated from Oaxaca, Mexico, to California, USA. Despite the patient's history of exposure to domestic and wild carnivores, molecular and phylogenetic characterizations suggested that the virus originated from insectivorous bats. Enhanced surveillance is needed to elucidate likely reservoirs. C1 [Velasco-Villa, Andres; Orciari, Lillian A.; Niezgoda, Michael; Blanton, Jesse D.; Rupprecht, Charles E.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Messenger, Sharon L.] Calif Dept Publ Hlth, Richmond, CA USA. [Fukagawa, Chris] Santa Barbara Cty Publ Hlth Dept, Santa Barbara, CA USA. RP Velasco-Villa, A (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop G33, Atlanta, GA 30333 USA. EM dly3@cdc.gov NR 14 TC 12 Z9 14 U1 0 U2 4 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD DEC PY 2008 VL 14 IS 12 BP 1906 EP 1908 DI 10.3201/eid1412.080671 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 401AZ UT WOS:000262911800014 PM 19046517 ER PT J AU Khumjui, C Choomkasien, P Dekumyoy, P Kusolsuk, T Kongkaew, W Chalamaat, M Jones, JL AF Khumjui, Chowalit Choomkasien, Pravit Dekumyoy, Paron Kusolsuk, Teera Kongkaew, Wandee Chalamaat, Mutita Jones, Jeffrey L. TI Outbreak of Trichinellosis Caused by Trichinella papuae, Thailand,2006 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID EPIDEMIOLOGY AB In 2006, the Thailand Ministry of Public Health studied 28 patients from a village in northern Thailand. All had myalgia, edema, fever, and gastrointestinal symptoms; most had eaten wild boar. A muscle biopsy specimen from a patient showed nonencapsulated larvae with a cytochrome oxidase I gene sequence of Trichinella papuae. C1 [Jones, Jeffrey L.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Khumjui, Chowalit; Choomkasien, Pravit; Kongkaew, Wandee; Chalamaat, Mutita] Minist Publ Hlth, Bangkok, Thailand. [Dekumyoy, Paron; Kusolsuk, Teera] Mahidol Univ, Bangkok 10700, Thailand. RP Jones, JL (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy NE,Mailstop F22, Atlanta, GA 30341 USA. EM jljl@cdc.gov NR 9 TC 28 Z9 29 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD DEC PY 2008 VL 14 IS 12 BP 1913 EP 1915 DI 10.3201/eid1412.080800 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 401AZ UT WOS:000262911800016 PM 19046519 ER PT J AU Petersen, JM Carlson, JK Dietrich, G Eisen, RJ Coombs, J Janusz, AM Summers, J Ben Beard, C Mead, PS AF Petersen, Jeannine M. Carlson, Jennifer K. Dietrich, Gabrielle Eisen, Rebecca J. Coombs, Jana Janusz, Aimee M. Summers, JoDee Ben Beard, C. Mead, Paul S. TI Multiple Francisella tularensis Subspecies and Clades, Tularemia Outbreak, Utah SO EMERGING INFECTIOUS DISEASES LA English DT Article ID UNITED-STATES; MARKERS; PCR AB In July 2007, a deer fly-associated outbreak of tularemia occurred in Utah. Human infections were caused by 2 clades (A1 and A2) of Francisella tularensis subsp. tularensis. Lagomorph carcasses from the area yielded evidence of infection with A1 and A2, as well as F tularensis subsp. holarctica. These findings indicate that multiple subspecies and clades can cause disease in a localized outbreak of tularemia. C1 [Petersen, Jeannine M.; Mead, Paul S.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Bacterial Zoonoses Branch, Ft Collins, CO 80521 USA. [Coombs, Jana; Summers, JoDee] Utah Dept Hlth, Salt Lake City, UT 84116 USA. RP Mead, PS (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Bacterial Zoonoses Branch, 3150 Rampart Rd, Ft Collins, CO 80521 USA. EM pmead@cdc.gov NR 14 TC 20 Z9 20 U1 0 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD DEC PY 2008 VL 14 IS 12 BP 1928 EP 1930 DI 10.3201/eid1412.080482 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 401AZ UT WOS:000262911800021 PM 19046524 ER PT J AU Schultz, M AF Schultz, Myron TI Who is this man and what did he accomplish? Theobald Smith SO EMERGING INFECTIOUS DISEASES LA English DT Biographical-Item C1 Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Schultz, M (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop D69, Atlanta, GA 30333 USA. EM mgs1@cdc.gov NR 1 TC 2 Z9 2 U1 1 U2 2 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD DEC PY 2008 VL 14 IS 12 BP 1939 EP 1942 DI 10.3201/eid1412.081188 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 401AZ UT WOS:000262911800024 ER PT J AU Sjolund, M Yam, J Schwenk, J Joyce, K Medalla, F Barzilay, E Whichard, JM AF Sjoelund, Maria Yam, Jennifer Schwenk, Jillian Joyce, Kevin Medalla, Felicita Barzilay, Ezra Whichard, Jean M. TI Human Salmonella Infection Yielding CTX-M beta-Lactamase, United States SO EMERGING INFECTIOUS DISEASES LA English DT Letter ID ESCHERICHIA-COLI C1 [Sjoelund, Maria; Yam, Jennifer; Schwenk, Jillian; Joyce, Kevin; Medalla, Felicita; Barzilay, Ezra; Whichard, Jean M.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Sjoelund, Maria; Yam, Jennifer; Joyce, Kevin] Atlanta Res & Educ Fdn, Atlanta, GA USA. RP Sjolund, M (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop G29, Atlanta, GA 30333 USA. EM fwt4@cdc.gov NR 10 TC 14 Z9 14 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD DEC PY 2008 VL 14 IS 12 BP 1957 EP 1959 DI 10.3201/eid1412.080494 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 401AZ UT WOS:000262911800034 PM 19046536 ER PT J AU Sackal, C Laudisoit, A Kosoy, M Massung, R Ererneeva, ME Karpathy, SE Van Wyk, K Gabitzsch, E Zeidner, NS AF Sackal, Cherilyn Laudisoit, Anne Kosoy, Michael Massung, Robert Ererneeva, Marina E. Karpathy, Sandor E. Van Wyk, Kristen Gabitzsch, Elizabeth Zeidner, Nordin S. TI Bartonella spp. and Rickettsia felis in Fleas, Democratic Republic of Congo SO EMERGING INFECTIOUS DISEASES LA English DT Letter ID INFECTIONS; PLAGUE C1 [Zeidner, Nordin S.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA. [Laudisoit, Anne] Univ Antwerp, B-2020 Antwerp, Belgium. [Laudisoit, Anne] Univ Liege, Liege, Belgium. [Massung, Robert; Ererneeva, Marina E.; Karpathy, Sandor E.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Gabitzsch, Elizabeth] Etub Corp, Seattle, WA USA. RP Zeidner, NS (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, 3150 Rampart Rd,Foothills Campus, Ft Collins, CO 80521 USA. EM naz2@cdc.gov RI Laudisoit, Anne/F-2646-2017 OI Laudisoit, Anne/0000-0001-7626-9426 NR 10 TC 30 Z9 30 U1 1 U2 4 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD DEC PY 2008 VL 14 IS 12 BP 1972 EP 1974 DI 10.3201/eid1412.080610 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 401AZ UT WOS:000262911800042 PM 19046544 ER PT J AU Pofter, P AF Pofter, Polyxeni TI Eye to Eye in the Village SO EMERGING INFECTIOUS DISEASES LA English DT Editorial Material C1 Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Pofter, P (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop D61, Atlanta, GA 30333 USA. EM PMP1@cdc.gov NR 5 TC 0 Z9 0 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD DEC PY 2008 VL 14 IS 12 BP 1978 EP 1980 DI 10.3201/eid1412.000000 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 401AZ UT WOS:000262911800045 ER PT J AU Schneider, A Neas, L Herbst, MC Case, M Williams, RW Cascio, W Hinderliter, A Holguin, F Buse, JB Dungan, K Styner, M Peters, A Devlin, RB AF Schneider, Alexandra Neas, Lucas Herbst, Margaret C. Case, Martin Williams, Ronald W. Cascio, Wayne Hinderliter, Alan Holguin, Fernando Buse, John B. Dungan, Kathleen Styner, Maya Peters, Annette Devlin, Robert B. TI Endothelial Dysfunction: Associations with Exposure to Ambient Fine Particles in Diabetic Individuals SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article DE air pollution; diabetes; endothelial dysfunction; environmental epidemiology; particulate matter ID PARTICULATE AIR-POLLUTION; S-TRANSFERASE M1; CORONARY-ARTERY-DISEASE; PULSE-WAVE ANALYSIS; CARDIOVASCULAR EVENTS; VASCULAR-DISEASE; OXIDATIVE STRESS; ENVIRONMENT INTERACTION; ASTHMATIC-CHILDREN; ALLERGIC RESPONSES AB BACKGROUND: Exposure to fine airborne particulate matter [<= 2.5 mu m in aerodynamic diameter (PM(2.5))] has been associated with cardiovascular and hematologic effects, especially in older people with cardiovascular disease. Some epidemiologic studies suggest that adults with diabetes also may be a particularly susceptible population. OBJECTIVES: The purpose of this study was to analyze the short-term effects of ambient PM(2.5) on markers of endothelial function in diabetic volunteers. METHODS: We conducted a prospective panel study in 22 people with type 2 diabetes mellitus in Chapel Hill, North Carolina (USA), from November 2004 to December 2005. We acquired daily measurements of PM(2.5) and meteorologic data at central monitoring sites. On 4 consecutive days, we measured endothelial function by brachial artery ultrasound in all participants and by pulsewave measurements in a subgroup. Data were analyzed using additive mixed models with a random participant effect and adjusted for season, day of the week, and meteorology. RESULTS: Flow-mediated dilatation decreased in association with PM(2.5) during the first 24 hr, whereas small-artery elasticity index decreased with a delay of 1 and 3 days. These PM(2.5)-associated decrements in endothelial function were greater among participants with a high body mass index, high glycosylated hemoglobin Ale, low adiponectin, or the null polymorphism of glutathione S-transferase M1. However, high levels of myeloperoxidase on the examination day led to strongest effects on endothelial dysfunction. CONCLUSIONS: These data demonstrate that PM(2.5) exposure may cause immediate endothelial dysfunction. Clinical characteristics associated with insulin resistance were associated with enhanced effects of PM on endothelial function. In addition, participants with greater oxidative potential seem to be more susceptible. C1 [Schneider, Alexandra; Peters, Annette] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol, D-85764 Neuherberg, Germany. [Neas, Lucas; Case, Martin; Devlin, Robert B.] US EPA, Human Studies Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Herbst, Margaret C.; Hinderliter, Alan; Buse, John B.; Styner, Maya] Univ N Carolina, Sch Med, Chapel Hill, NC USA. [Williams, Ronald W.] US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Cascio, Wayne] E Carolina Sch Med, Greenville, NC USA. [Holguin, Fernando] Ctr Dis Control & Prevent, Atlanta, GA USA. [Dungan, Kathleen] Ohio State Univ, Div Endocrinol Diabet & Metab, Columbus, OH 43210 USA. [Peters, Annette] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Focus Network Nanoparticles & Hlth NanoHlth, Neuherberg, Germany. RP Schneider, A (reprint author), Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany. EM alexandra.schneider@helmholtz-muenchen.de RI Dungan, Kathleen/E-2999-2011; Neas, Lucas/J-9378-2012; Schneider, Alexandra/B-5347-2014; Peters, Annette/A-6117-2011; OI Buse, John/0000-0002-9723-3876 FU U.S. Environmental Protection Agency (EPA) [CR83346301]; Division of Research Resources [RR00046]; U.S. National Institutes of Health; Helmholtz Zentrum Munchen-German Research Center for Environmental Health; Rochester Particle Center [RD832415]; U.S. Environmental Protection Agency; University of North Carolina at Chapel Hill FX This study was funded by U.S. Environmental Protection Agency (EPA) cooperative agreement CR83346301, and by RR00046 from the General Clinical Research Centers program of the Division of Research Resources, U.S. National Institutes of Health. The analysis was performed in cooperation with the Helmholtz Zentrum Munchen-German Research Center for Environmental Health and partly funded by Rochester Particle Center grant RD832415.; Although the research described in this article has been funded wholly or in part by the U.S. Environmental Protection Agency through a cooperative agreement with the Center for Environmental Medicine, Asthma, and Lung Biology at the University of North Carolina at Chapel Hill, it has nor been subjected to the agency's required peer and policy review and therefore does not necessarily reflect the views of the agency. No official endorsement should be inferred. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 71 TC 69 Z9 70 U1 0 U2 11 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD DEC PY 2008 VL 116 IS 12 BP 1666 EP 1674 DI 10.1289/ehp.11666 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 377ZG UT WOS:000261290300029 PM 19079718 ER PT J AU Williams, MK Rundle, A Holmes, D Reyes, M Hoepner, LA Barr, DB Camann, DE Perera, FP Whyatt, RM AF Williams, Megan K. Rundle, Andrew Holmes, Darrell Reyes, Marilyn Hoepner, Lori A. Barr, Dana B. Camann, David E. Perera, Frederica P. Whyatt, Robin M. TI Changes in Pest Infestation Levels, Self-Reported Pesticide Use, and Permethrin Exposure during Pregnancy after the 2000-2001 US Environmental Protection Agency Restriction of Organophosphates SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article DE indoor air; insecticides; pregnancy; residential ID GERMAN-COCKROACH DICTYOPTERA; NEW-YORK-CITY; PYRETHROID INSECTICIDES; BLATTELLIDAE; RESISTANCE; CHILDREN; COHORT; IDENTIFICATION; NEUROTOXICITY; SYNERGISM AB BACKGROUND: Widespread residential pesticide use throughout the United States has resulted in ubiquitous, low-level pesticide exposure. The mix of active pesticide ingredients is changing in response to 2000-2001 regulations restricting use of the organophosphorus insecticides chlorpyrifos and diazinon. OBJECTIVES: We aimed to determine the impact of U.S. Environmental Protection Agency regulations on pest infestation levels, pesticide use, and pesticides measured in indoor air samples. METHODOLOGY: 511 pregnant women from inner-city New York were enrolled between 2000 and 2006. Permethrin, a pyrethroid insecticide; piperonyl butoxide (PBO), a pyrethroid synergist; chlorpyrifos; and diazinon were measured in 48-hr prenatal personal air samples. Data on pest infestation and pesticide use were collected via questionnaire. RESULTS: Eighty-eight percent of women reported using pesticides during pregnancy; 55% reported using higher-exposure pesticide applications (spray cans, pest bombs and/or professional pesticide applicators). Self-reported pest sightings and use of higher-exposure applications increased significantly after the regulations were implemented (p < 0.001). PBO, cis-, and trans-permethrin were detected in 75, 19, and 18% of personal air samples, respectively. Detection frequencies of PBO and cis- and trans-permethrin increased significantly over time (p < 0.05 controlling for potential confounders). Levels and/or detection frequencies of these compounds were significantly higher among mothers reporting use of high exposure pesticide applications. (p <= 0.05). Chlorpyrifos and diazimon levels decreased significantly over time (p < 0.001). CONCLUSION: In this cohort, pest infestations, use of pesticides, and use of permethrin appear to increase after the residential restriction of organophosphorus insecticides. This is one of the first studies to document widespread residential exposure to PBO. C1 [Williams, Megan K.] Columbia Univ, Joseph L Mailman Sch Publ Hlth, Dept Environm Hlth Sci, Columbia Ctr Childrens Environm Hlth, New York, NY 10032 USA. [Barr, Dana B.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Camann, David E.] SW Res Inst, San Antonio, TX USA. RP Williams, MK (reprint author), Columbia Univ, Joseph L Mailman Sch Publ Hlth, Dept Environm Hlth Sci, Columbia Ctr Childrens Environm Hlth, 60 Haven Ave,B-109, New York, NY 10032 USA. EM mh2l80@columbia.edu RI Rundle, Andrew/A-5282-2009; Barr, Dana/E-6369-2011; Barr, Dana/E-2276-2013; OI Rundle, Andrew/0000-0003-0211-7707; Hoepner, Lori/0000-0002-4404-8140 FU National Institute of Environmental Health Sciences [P50 ES09600, ROI ES012468, ROI ES08977, ROI ES11158]; U.S. Environmental Protection Agency [R827027, R82860901]; National Institutes of Health [TL1 RR024158] FX This study was supported by National Institute of Environmental Health Sciences grants P50 ES09600, ROI ES012468, ROI ES08977, and ROI ES11158; U.S. Environmental Protection Agency grants R827027 and R82860901; and National Institutes of Health grant TL1 RR024158. NR 36 TC 43 Z9 43 U1 3 U2 13 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD DEC PY 2008 VL 116 IS 12 BP 1681 EP 1688 DI 10.1289/ehp.11367 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 377ZG UT WOS:000261290300031 PM 19079720 ER PT J AU Shaw, KM Santibanez, TA Chu, SY AF Shaw, Kate M. Santibanez, Tammy A. Chu, Susan Y. TI ASIAN AND PACIFIC ISLANDER CHILDHOOD VACCINATION COVERAGE: NATIONAL IMMUNIZATION SURVEY, 2002-2004 SO ETHNICITY & DISEASE LA English DT Article DE Asians; Pacific Island Americans; Vaccination ID HEALTH AB Objective: Public health data on Asian/Pacific islanders are most often collected and reported as one aggregated group. This aggregation of data can mask potential differences among the many ethnic/national/cultural groups classified as Asian/Pacific islanders. We used data from the National immunization Survey (NIS) to examine immunization status for all US children and four mutually exclusive groups: Asian only, Native Hawaiian only, Pacific Islander only, and other. Methods: We included information from 64,718 US children 19-35 months of age who had adequate vaccination histories from provider(s) for 2002 to 2004; among these, 2673 (4.3%) were Asian only, Native Hawaiian only, or Pacific Islander only. The sample sizes reported are unweighted, while results are based on weighted analyses. Results: Vaccination coverage estimates for children in the Native Hawaiian only group were consistently higher than estimates for all US children, whereas those in the Asian only group were nearly the same. Children in the Pacific Islander only group had vaccination coverage estimates that were lower than estimates for all US children. Conclusion: The results of this study indicated that although overall the Asian/Pacific Islander group had similar childhood vaccination coverage to all US children, the group does not have homogeneous coverage, with Pacific Islanders having lower coverage. Public health researchers should, whenever possible, examine individual groups of Asian/Pacific Islanders to more accurately measure the health status of this growing population. (Ethn Dis. 20081;18:72-76) C1 [Shaw, Kate M.] CDC, NCCDPHP, Atlanta, GA 30341 USA. [Santibanez, Tammy A.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Shaw, KM (reprint author), CDC, NCCDPHP, 4770 Buford Hwy NE, Atlanta, GA 30341 USA. EM atk6@cdc.gov NR 16 TC 1 Z9 1 U1 0 U2 1 PU INT SOC HYPERTENSION BLACKS-ISHIB PI ATLANTA PA 100 AUBURN AVE NE STE 401, ATLANTA, GA 30303-2527 USA SN 1049-510X J9 ETHNIC DIS JI Ethn. Dis. PD WIN PY 2008 VL 18 IS 1 BP 72 EP 76 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 489MA UT WOS:000269423000013 PM 18447103 ER PT J AU Pearson, WS Ahluwalia, IB Ford, ES Mokdad, AH AF Pearson, William S. Ahluwalia, Indu B. Ford, Earl S. Mokdad, Ali H. TI LANGUAGE PREFERENCE AS A PREDICTOR OF ACCESS TO AND USE OF HEALTHCARE SERVICES AMONG HISPANICS IN THE UNITED STATES SO ETHNICITY & DISEASE LA English DT Article DE Hispanic; Access; Disparities; Language; Barriers to Care ID INDIVIDUALS; DISPARITIES; BARRIERS AB Objectives: The objective of this study was to determine if Spanish language preference was significantly associated with barriers to healthcare services among a nationally representative sample of Hispanic persons in the United States. Design: Cross-sectional analysis of secondary data. Differences in outcomes between those responding in Spanish and those responding in English were tested using chi-square analyses and Multiple logistic regression models. Setting: Nationally representative sample of US adults responding to the 2005 Behavioral Risk Factor Surveillance System survey. Participants: Respondents identifying themselves as Hispanic (n=20,400). Main Outcome Measures: Four health care outcomes including health insurance coverage, having a personal health care provider, forgoing care because of cost, and having a routine check-up within the past five years. Results: Those responding in Spanish were less likely to have healthcare coverage, less likely to have a personal healthcare provider, and less likely to have had a routine check-up within the past five years. No difference was found for indicating that cost was a barrier to receiving care in this model. Conclusions: Disparities in healthcare access exist between Hispanic persons in the United States whose language preference is Spanish and those whose language preference is English. in an effort to achieve Healthy People 2010 goals and to provide care to all persons in the United States, barriers to care, such as language preference, should be addressed more fully in our healthcare system. (Ethn Dis. 2008;18:93-97) C1 [Pearson, William S.; Ahluwalia, Indu B.; Ford, Earl S.; Mokdad, Ali H.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Atlanta, GA 30341 USA. RP Pearson, WS (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, 4770 Buford Highway NE,MS K66, Atlanta, GA 30341 USA. EM wpearson@cdc.gov NR 25 TC 26 Z9 26 U1 2 U2 6 PU INT SOC HYPERTENSION BLACKS-ISHIB PI ATLANTA PA 100 AUBURN AVE NE STE 401, ATLANTA, GA 30303-2527 USA SN 1049-510X J9 ETHNIC DIS JI Ethn. Dis. PD WIN PY 2008 VL 18 IS 1 BP 93 EP 97 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 489MA UT WOS:000269423000017 PM 18447107 ER PT J AU Mor, Z Migliori, GB Althomsons, SP Loddenkemper, R Trnka, L Iademarco, MF AF Mor, Z. Migliori, G. B. Althomsons, S. P. Loddenkemper, R. Trnka, L. Iademarco, M. F. TI Comparison of tuberculosis surveillance systems in low-incidence industrialised countries SO EUROPEAN RESPIRATORY JOURNAL LA English DT Article DE Global health; National Tuberculosis Programme; surveillance; tuberculosis ID EUROPE; COMPLETENESS; ELIMINATION AB The comparative analysis of National Tuberculosis Control Programmes (NTPs) in industrialised, low-tuberculosis-incidence countries is limited. Analysis of applied methods, function and accumulated experience contributes to improving global tuberculosis control. A questionnaire addressing NTP surveillance infrastructure and characteristics was completed in 19 industrialised countries, with populations of >3 million and annual notified tuberculosis incidence rates of <16 cases per 100,000 population (2003 data). All European countries surveyed adopted World Health Organization Collaborating Centre for the Surveillance of Tuberculosis in Europe (EuroTB) definitions. Surveillance information, which usually includes names, was transferred electronically to the national level in 17 out of the 19 countries. Surveillance systems capture process and social determinants. Case notification to the central level occurred within a median period of 7 days, independent of mandatory notification requirements. The mean completeness of tuberculosis case-reporting was estimated to be 93.5% (range 65-100%). Integration between HIV and tuberculosis registries was performed in two countries, and, in seven others, both databases were cross-matched periodically. National Tuberculosis Control Programme function in industrialised low-incidence countries utilises well-established infrastructure and relies upon centralised operations. Approaches are consistent with current World Health Organization surveillance recommendations. The present study lays collaborative groundwork for additional multinational analyses for the enhancement of global tuberculosis surveillance, which may assist policy-makers in countries moving from medium to low rates of incidence. C1 [Althomsons, S. P.; Iademarco, M. F.] US Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA. [Mor, Z.] Minist Hlth, Publ Hlth Serv, Jerusalem, Israel. [Althomsons, S. P.] CDC Programs, Northrop Grumman Informat Technol, Atlanta, GA USA. [Migliori, G. B.] Care & Res Inst, S Maugeri Fdn, WHO Collaborating Ctr TB & Lung Dis, Tradate, Italy. [Loddenkemper, R.] German Cent Comm TB, Berlin, Germany. [Trnka, L.] Bulovka Hosp, Natl TB Surveillance Unit, Prague, Czech Republic. RP Iademarco, MF (reprint author), US Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA. EM iademarcoMF@state.gov RI Alkhalawi, Mohammed/C-6111-2012; OI Migliori, Giovanni Battista/0000-0002-2597-574X NR 31 TC 18 Z9 18 U1 0 U2 3 PU EUROPEAN RESPIRATORY SOC JOURNALS LTD PI SHEFFIELD PA 442 GLOSSOP RD, SHEFFIELD S10 2PX, ENGLAND SN 0903-1936 J9 EUR RESPIR J JI Eur. Resp. J. PD DEC PY 2008 VL 32 IS 6 BP 1616 EP 1624 DI 10.1183/09031936.00042908 PG 9 WC Respiratory System SC Respiratory System GA 384DT UT WOS:000261725200028 PM 18684850 ER PT J AU Gerner-Smidt, P Whichard, JM AF Gerner-Smidt, Peter Whichard, Jean M. TI Foodborne Disease Trends and Reports SO FOODBORNE PATHOGENS AND DISEASE LA English DT Editorial Material ID ENTEROBACTER-SAKAZAKII C1 [Gerner-Smidt, Peter; Whichard, Jean M.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Gerner-Smidt, P (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1535-3141 J9 FOODBORNE PATHOG DIS JI Foodborne Pathog. Dis. PD DEC PY 2008 VL 5 IS 6 BP 703 EP 707 DI 10.1089/fpd.2008.9991 PG 5 WC Food Science & Technology SC Food Science & Technology GA 388OF UT WOS:000262028400002 PM 19086803 ER PT J AU Pagava, S Rusetski, V Robakidze, Z Farfan, EB Dunker, RE Popp, JL Avtandilashvili, M Wells, DP Donnelly, EH AF Pagava, S. Rusetski, V. Robakidze, Z. Farfan, E. B. Dunker, R. E. Popp, J. L. Avtandilashvili, M. Wells, D. P. Donnelly, E. H. TI INITIAL INVESTIGATION OF Rn-222 IN THE TBILISI URBAN ENVIRONMENT SO HEALTH PHYSICS LA English DT Article DE radon; dose; electrets; Rn-222 AB Georgia has geological formations with high uranium content, and several buildings are built with local materials. This can create potentially high radon exposures. Consequently, studies to mitigate these exposures have been started. This study presents a preliminary investigation of radon in Tbilisi, the capital of Georgia. An independent radiological monitoring program in Georgia has been initiated by the Radiocarbon and Low-Level Counting Section of I. Javakhishvili Tbilisi State University with the cooperation of the Environmental Monitoring Laboratory of the Physics/Health Physics Department at Idaho State University. At this initial stage the E-PERM systems and GammaTRACER were used for the measurement of gamma exposure and radon concentrations in air and water. Measurements in Sololaki, a densely populated historic district of Tbilisi, revealed indoor radon (Rn-222) concentrations of 1.5-2.5 times more than the U.S. Environmental Protection Agency action level of 148 Bq m(-3) (4 pCi L-1). Moreover, radon-in-air concentrations of 440 Bq m-3 and 3,500 Bq m(-3) were observed at surface borehole openings within the residential district. Measurements of water from various tap water supplies displayed radon concentrations of 3-5 Bq L-1 while radon concentrations in water from the hydrogeological and thermal water boreholes were 5-19 Bq L-1. In addition, the background gamma absorbed dose rate in air ranged of 70-115 nGy h(-1) at the radon test locations throughout the Tbilisi urban environment. C1 [Farfan, E. B.] Savannah River Natl Lab, Aiken, SC 29808 USA. [Pagava, S.; Rusetski, V.; Robakidze, Z.] I Javakhishvilli Tbilisi State Univ, Radiocarbon & Low Level Counting Sect, GE-0128 Tbilisi, Rep of Georgia. [Dunker, R. E.; Popp, J. L.; Avtandilashvili, M.] Idaho State Univ, Dept Phys Hlth Phys, Pocatello, ID 83209 USA. [Wells, D. P.] Idaho Accelerator Ctr, Pocatello, ID 83201 USA. [Donnelly, E. H.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. RP Farfan, EB (reprint author), Savannah River Natl Lab, 773-42A Savannah River Site, Aiken, SC 29808 USA. EM Eduardo.Farfan@srnl.doe.gov NR 13 TC 0 Z9 0 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD DEC PY 2008 VL 95 IS 6 BP 761 EP 765 DI 10.1097/01.HP.0000319909.18881.5e PG 5 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA 373QK UT WOS:000260986800006 PM 19001903 ER PT J AU Echeverria, S Diez-Roux, AV Shea, S Borrell, LN Jackson, S AF Echeverria, Sandra Diez-Roux, Ana V. Shea, Steven Borrell, Luisa N. Jackson, Sharon TI Associations of neighborhood problems and neighborhood social cohesion with mental health and health behaviors: The Multi-Ethnic Study of Atherosclerosis SO HEALTH & PLACE LA English DT Review DE neighborhood characteristics; measurement; mental health; health behaviors ID MULTILEVEL ANALYSIS; PHYSICAL-ACTIVITY; CES-D; SOCIOECONOMIC-STATUS; COLLECTIVE EFFICACY; ALAMEDA COUNTY; OLDER-ADULTS; RISK-FACTORS; DISORDER; DEPRESSION AB Few studies have investigated the specific features implicated in neighborhood-health associations. We examined associations between measures of neighborhood problems and neighborhood social cohesion with depression, smoking, drinking, and walking for exercise in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort. Neighborhoods were characterized according to participant self-report and aggregated measures based on other MESA participants. Individuals living in the least problematic neighborhoods were significantly less likely to be depressed, to smoke, or to drink. Less socially cohesive neighborhoods were associated with increased depression, smoking, and not walking for exercise. Results persisted after adjusting for individual-level variables. Each measure appeared to capture distinct features of the neighborhood and associations did not differ by race/ethnicity. Results for neighborhood problems were robust to the use of aggregate measures but results for social cohesion generally were not. Future work should determine the health effect of modifying specific features of the neighborhood context. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Echeverria, Sandra] Univ Med & Dent New Jersey, Sch Publ Hlth, Dept Epidemiol, Piscataway, NJ 08854 USA. [Echeverria, Sandra] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Family Med, Piscataway, NJ 08854 USA. [Diez-Roux, Ana V.] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48104 USA. [Shea, Steven] Columbia Univ, Coll Phys & Surg, Div Gen Med, New York, NY USA. [Borrell, Luisa N.] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA. [Jackson, Sharon] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Echeverria, S (reprint author), Univ Med & Dent New Jersey, Sch Publ Hlth, Dept Epidemiol, Piscataway, NJ 08854 USA. EM echevese@umdnj.edu FU NHLBI NIH HHS [N01-HC-95159, N01-HC-95169, N01-HC95161, N01-HC95165, R01 HL071759] NR 66 TC 113 Z9 115 U1 7 U2 37 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1353-8292 J9 HEALTH PLACE JI Health Place PD DEC PY 2008 VL 14 IS 4 BP 853 EP 865 DI 10.1016/j.healthplace.2008.01.004 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 331HJ UT WOS:000258003000019 PM 18328772 ER PT J AU Anda, RF Brown, DW AF Anda, Robert F. Brown, David W. TI Smoking among Youth in East Timor-Leste: What are the Dynamics? SO INDIAN PEDIATRICS LA English DT Editorial Material C1 [Anda, Robert F.; Brown, David W.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. RP Anda, RF (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway,NE MS K67, Atlanta, GA 30341 USA. EM rfal@cdc.gov NR 7 TC 1 Z9 1 U1 0 U2 0 PU INDIAN ACAD PEDIATRICS PI NEW DELHI PA MAULANA AZAD MEDICAL COLLEGE, DEPT PEDIATRICS, NEW DELHI, 110 002, INDIA SN 0019-6061 J9 INDIAN PEDIATR JI Indian Pediatrics PD DEC PY 2008 VL 45 IS 12 BP 961 EP 962 PG 2 WC Pediatrics SC Pediatrics GA 393QF UT WOS:000262387100003 PM 19129562 ER PT J AU Srinivasan, A Patel, JB AF Srinivasan, Arjun Patel, Jean B. TI Klebsiella pneumoniae Carbapenemase-Producing Organisms: An Ounce of Prevention Really Is Worth a Pound of Cure SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Editorial Material ID BETA-LACTAMASES; STRAINS; KPC-3 C1 [Srinivasan, Arjun; Patel, Jean B.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. RP Srinivasan, A (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, 1600 Clifton Rd,MS A35, Atlanta, GA 30333 USA. EM asrinivasan@cdc.gov NR 9 TC 35 Z9 39 U1 0 U2 6 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD DEC PY 2008 VL 29 IS 12 BP 1107 EP 1109 DI 10.1086/594129 PG 3 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 373WA UT WOS:000261003000002 PM 18973453 ER PT J AU Marcet, PL Mora, MS Cutrera, AP Jones, L Gurtler, RE Kitron, U Dotson, EM AF Marcet, P. L. Mora, M. S. Cutrera, A. P. Jones, L. Guertler, R. E. Kitron, U. Dotson, E. M. TI Genetic structure of Triatoma infestans populations in rural communities of Santiago del Estero, northern Argentina SO INFECTION GENETICS AND EVOLUTION LA English DT Article DE Chagas disease; Triatoma infestans; Vector control; Population structure; Microsatellite loci ID CHAGAS-DISEASE VECTOR; MULTILOCUS GENOTYPE DATA; FLIGHT INITIATION; NORTHWESTERN ARGENTINA; MICROSATELLITE MARKERS; NATURAL-POPULATIONS; ACTIVE DISPERSAL; REDUVIIDAE POPULATIONS; NUTRITIONAL-STATUS; WESTERN ARGENTINA AB To gain an understanding of the genetic structure and dispersal dynamics of Triatoma infestans populations, we analyzed the multilocus genotype of 10 microsatellite loci for 352 T infestans collected in 21 houses of 11 rural communities in October 2002. Genetic structure was analyzed at the community and house compound levels. Analysis revealed that vector control actions affected the genetic structure of T infestans populations. Bug populations from communities under sustained vector control (core area) were highly structured and genetic differentiation between neighboring house compounds was significant. In contrast, bug populations from communities with sporadic vector control actions were more homogeneous and lacked defined genetic clusters. Genetic differentiation between population pairs did not fit a model of isolation by distance at the microgeographical level. Evidence consistent with flight or walking bug dispersal was detected within and among Communities, dispersal was more female-biased in the core area and results suggested that houses received immigrants from more than one source. Putative sources and mechanisms of re-infestation are described. These data may be use to design improved vector control strategies. Published by Elsevier B.V. C1 [Marcet, P. L.] Ctr Dis Control & Prevent, NCZVED DPD Entomol Branch, CDC, CCID, Chamblee, GA 30341 USA. [Marcet, P. L.; Guertler, R. E.] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Lab Ecoepidemiol, Buenos Aires, DF, Argentina. [Kitron, U.] Emory Univ, Dept Environm Studies, Atlanta, GA 30322 USA. [Mora, M. S.; Cutrera, A. P.] Univ Nacl Mar del Plata, Lab Ecofisiol, Fac Ciencias Exactas & Nat, Mar Del Plata, Buenos Aires, Argentina. RP Marcet, PL (reprint author), Ctr Dis Control & Prevent, NCZVED DPD Entomol Branch, CDC, CCID, MS F-42,4770 Buford Highway NE, Chamblee, GA 30341 USA. EM pmarcet@cdc.gov RI marcet, Paula/B-1758-2012; OI Marcet, Paula/0000-0002-0676-3020 FU National Institutes of Health/National Science Foundation [R01 TW05836]; Fogarty International Center; National Institute of Environmental Health Sciences; Agencia Nacional de Promocion Cientifica y Tecnica (Argentina); University of Buenos Aires FX The authors would like to thank: G. Lawrence, LA. Ceballos, M.V. Cardinal, M.C. Cecere, G.M. Vazquez-Prokopec, D.M. Canale and R. Stariolo who participated in field or laboratory work; to A. Peixoto, A.G. Schijman, V. Confalonieri and two anonymous referees for valuable comments and suggestions on earlier versions of the manuscript. To the CDC core facilities for providing the oligonucleotides. This study was supported by awards from the National Institutes of Health/National Science Foundation Ecology of Infectious Disease program award R01 TW05836 funded by the Fogarty International Center and the National Institute of Environmental Health Sciences to U. Kitron and R.E. Gurtler, the Agencia Nacional de Promocion Cientifica y Tecnica (Argentina), and University of Buenos Aires to R.E. Gurtler. R.E. Gurtler is member of CONICET Researcher's Career. NR 54 TC 38 Z9 38 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1567-1348 J9 INFECT GENET EVOL JI Infect. Genet. Evol. PD DEC PY 2008 VL 8 IS 6 BP 835 EP 846 DI 10.1016/j.meegid.2008.08.002 PG 12 WC Infectious Diseases SC Infectious Diseases GA 382HG UT WOS:000261596000011 PM 18773972 ER PT J AU Hollier, LM Workowski, K AF Hollier, Lisa M. Workowski, Kimberly TI Treatment of Sexually Transmitted Infections in Women SO INFECTIOUS DISEASE CLINICS OF NORTH AMERICA LA English DT Review ID HERPES-SIMPLEX-VIRUS; PELVIC-INFLAMMATORY-DISEASE; RECURRENT GENITAL HERPES; TRICHOMONAS-VAGINALIS INFECTION; PLACEBO-CONTROLLED TRIAL; CHLAMYDIA-TRACHOMATIS; BACTERIAL VAGINOSIS; PREGNANT-WOMEN; UNITED-STATES; NEISSERIA-GONORRHOEAE AB Sexually transmitted infections remain a major public health concern in the United States. An estimated 19 million infections occur each year. The economic burden imposed by sexually transmitted infections is impressive: direct medical costs are estimated to be as high as $15.5 billion annually. Women and infants disproportionately bear the long-term consequences of sexually transmitted diseases. This article briefly introduces various infections, reviews new diagnostic information, and presents the latest guidelines for therapy. All recommended and alternative regimens are drawn from the most recent Centers for Disease Control and Prevention treatment guidelines and recent updates. C1 [Hollier, Lisa M.] Univ Texas Med Sch Houston, Dept Obstet Gynecol & Reprod Sci, LBJ Gen Hosp, Houston, TX 77026 USA. [Workowski, Kimberly] Emory Univ, Div Infect Dis, Atlanta, GA 30308 USA. [Workowski, Kimberly] Ctr Dis Control & Prevent, Guidelines Unit, Epidemiol & Surveillance Branch, Div STD Prevent, Atlanta, GA 30333 USA. RP Hollier, LM (reprint author), Univ Texas Med Sch Houston, Dept Obstet Gynecol & Reprod Sci, LBJ Gen Hosp, 5656 Kelley St, Houston, TX 77026 USA. EM lisa.m.hollier@uth.tmc.edu NR 107 TC 1 Z9 5 U1 1 U2 5 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0891-5520 J9 INFECT DIS CLIN N AM JI Infect. Dis. Clin. North Am. PD DEC PY 2008 VL 22 IS 4 BP 665 EP + DI 10.1016/j.idc.2008.05.009 PG 28 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 374XO UT WOS:000261077200007 PM 18954758 ER PT J AU Theiler, RN Rasmussen, SA Treadwell, TA Jamieson, DJ AF Theiler, Regan N. Rasmussen, Sonja A. Treadwell, Tracee A. Jamieson, Denise J. TI Emerging and Zoonotic Infections in Women SO INFECTIOUS DISEASE CLINICS OF NORTH AMERICA LA English DT Article ID WEST-NILE-VIRUS; ACUTE RESPIRATORY SYNDROME; BORNE RELAPSING FEVER; INFLUENZA-A H5N1; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; RIFT-VALLEY FEVER; HANTAVIRUS PULMONARY SYNDROME; EBOLA HEMORRHAGIC-FEVER; PREGNANT-WOMEN; UNITED-STATES AB Emerging infections, many zoonotic, are caused by a variety of pathogens with global distribution. Previously rare pathogens have emerged; global travel facilitates their rapid spread. Human encroachment on remote areas has brought contact With zoonotic diseases never before characterized. Although systematic study of rare outbreaks can be challenging, knowledge of emerging pathogens and their effects on women is accumulating. This article discusses effects of lymphocytic choriomeningitis virus, West Nile virus, severe acute respiratory syndrome coronavirus, avian influenza A virus, viral hemorrhagic fevers, spirochetal illnesses, and Chagas' disease. The potential impact of candidate bioterror agents and issues of prophylaxis and therapy are discussed. C1 [Theiler, Regan N.] Univ Texas Med Branch, Dept Obstet & Gynecol, Galveston, TX 77550 USA. [Rasmussen, Sonja A.] Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Treadwell, Tracee A.] Ctr Dis Control & Prevent, Natl Ctr Zoonot Vectorborne & Enter Dis, Atlanta, GA 30333 USA. [Jamieson, Denise J.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Theiler, RN (reprint author), Univ Texas Med Branch, Dept Obstet & Gynecol, 301 Univ Blvd, Galveston, TX 77550 USA. EM rntheile@utmb.edu OI Rasmussen, Sonja/0000-0002-0574-4928; Theiler, Regan/0000-0002-3412-3653 FU National Institutes of Health Women's Reproductive Health Research [NICHD5K12 HD001269-08] FX R.N.T. is supported by National Institutes of Health Women's Reproductive Health Research grant number NICHD5K12 HD001269-08. NR 98 TC 14 Z9 17 U1 1 U2 5 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0891-5520 J9 INFECT DIS CLIN N AM JI Infect. Dis. Clin. North Am. PD DEC PY 2008 VL 22 IS 4 BP 755 EP + DI 10.1016/j.idc.2008.05.007 PG 20 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 374XO UT WOS:000261077200011 PM 18954762 ER PT J AU Ansari, JA Kazi, BM Salman, M Asghar, RJ AF Ansari, J. A. Kazi, B. M. Salman, M. Asghar, R. J. TI Evaluation of the Existing Bacterial Meningitis Surveillance System in Islamabad, Pakistan SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Kazi, B. M.; Salman, M.] Natl Inst Hlth, Islamabad, Pakistan. [Asghar, R. J.] Ctr Dis Control & Prevent, Atlanta, GA USA. RI Alkhalawi, Mohammed/C-6111-2012 NR 0 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD DEC PY 2008 VL 12 BP E192 EP E192 DI 10.1016/j.ijid.2008.05.477 PG 1 WC Infectious Diseases SC Infectious Diseases GA 406II UT WOS:000263287800476 ER PT J AU Chillag, K AF Chillag, K. TI Can Expanded Treatment Slow the AIDS Epidemic? The Behavioral Scientist's View SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Chillag, K.] CDC, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD DEC PY 2008 VL 12 BP E41 EP E41 DI 10.1016/j.ijid.2008.05.152 PG 1 WC Infectious Diseases SC Infectious Diseases GA 406II UT WOS:000263287800111 ER PT J AU Fischer, M Hills, S Staples, E Johnson, B Yaich, M Solomon, T AF Fischer, M. Hills, S. Staples, E. Johnson, B. Yaich, M. Solomon, T. TI Measuring Japanese Encephalitis Disease Burden: Challenges in Surveillance and Diagnostics SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Fischer, M.; Staples, E.; Johnson, B.] CDC, Ft Collins, CO USA. [Hills, S.; Yaich, M.] PATH, Seattle, WA USA. [Solomon, T.] Univ Liverpool, Liverpool L69 3BX, Merseyside, England. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD DEC PY 2008 VL 12 BP E33 EP E33 DI 10.1016/j.ijid.2008.05.130 PG 1 WC Infectious Diseases SC Infectious Diseases GA 406II UT WOS:000263287800089 ER PT J AU Gerberding, J AF Gerberding, J. TI 21st Century Global Health Protection SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Gerberding, J.] CDC, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD DEC PY 2008 VL 12 BP E21 EP E21 DI 10.1016/j.ijid.2008.05.097 PG 1 WC Infectious Diseases SC Infectious Diseases GA 406II UT WOS:000263287800056 ER PT J AU Hanlon, CA Costa, PJ Tumpey, A Cleaveland, S Doyle, K Briggs, DJ AF Hanlon, C. A. Costa, P. J. Tumpey, A. Cleaveland, S. Doyle, K. Briggs, D. J. TI World Rabies Day: A collaborative initiative to ... Make Rabies History! SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Hanlon, C. A.] Kansas State Univ, Manhattan, KS 66506 USA. [Tumpey, A.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD DEC PY 2008 VL 12 BP E445 EP E446 DI 10.1016/j.ijid.2008.05.1296 PG 2 WC Infectious Diseases SC Infectious Diseases GA 406II UT WOS:000263287801115 ER PT J AU Homaira, N Rahman, M Hossain, MJ Khatun, S Nahar, N Podder, G Gurley, ES Ksiazek, TG Luby, SP AF Homaira, N. Rahman, M. Hossain, M. J. Khatun, S. Nahar, N. Podder, G. Gurley, E. S. Ksiazek, T. G. Luby, S. P. TI Evidence of Person-to-Person Transmission of Nipah Virus Through Casual Contact SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Homaira, N.; Hossain, M. J.; Nahar, N.; Podder, G.; Gurley, E. S.; Luby, S. P.] ICDDR B, Dhaka, 30333, Bangladesh. [Rahman, M.; Khatun, S.] IEDCR, Dhaka, Bangladesh. [Ksiazek, T. G.] CDC, Atlanta, GA USA. RI Gurley, Emily/B-7903-2010 OI Gurley, Emily/0000-0002-8648-9403 NR 0 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 EI 1878-3511 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD DEC PY 2008 VL 12 SU 1 BP E99 EP E99 DI 10.1016/j.ijid.2008.05.248 PG 1 WC Infectious Diseases SC Infectious Diseases GA 406II UT WOS:000263287800247 ER PT J AU Markel, H Stern, A Cetron, M AF Markel, H. Stern, A. Cetron, M. TI Nonpharmaceutical Interventions Implemented by US Cities During the 1918-1919 Influenza Pandemic SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Markel, H.; Stern, A.] Univ Michigan, Ann Arbor, MI 48109 USA. [Cetron, M.] CDC, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD DEC PY 2008 VL 12 BP E432 EP E432 DI 10.1016/j.ijid.2008.05.1263 PG 1 WC Infectious Diseases SC Infectious Diseases GA 406II UT WOS:000263287801082 ER PT J AU Markotter, W Kuzmin, I Rupprecht, CE Nel, LH AF Markotter, W. Kuzmin, I. Rupprecht, C. E. Nel, L. H. TI Pathogenicity of Lagos Bat Virus - An African Rabies-Related Lyssavirus SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Markotter, W.; Nel, L. H.] Univ Pretoria, ZA-0002 Pretoria, South Africa. [Kuzmin, I.; Rupprecht, C. E.] Ctr Dis Control & Prevent, Atlanta, GA USA. RI Markotter, Wanda/A-2129-2010; Nel, Louis/F-1001-2012 NR 0 TC 0 Z9 0 U1 1 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD DEC PY 2008 VL 12 BP E59 EP E59 DI 10.1016/j.ijid.2008.05.036 PG 1 WC Infectious Diseases SC Infectious Diseases GA 406II UT WOS:000263287800150 ER PT J AU Mascola, L Kun, H Moore, A Steurer, F Lawrence, G Kubak, B Radhakrishna, S Leiby, D Herron, R Mone, T Hunter, R Kuehnert, M AF Mascola, L. Kun, H. Moore, A. Steurer, F. Lawrence, G. Kubak, B. Radhakrishna, S. Leiby, D. Herron, R. Mone, T. Hunter, R. Kuehnert, M. TI Transmission of Trypanosoma cruzi Infection by Organ Transplantation, Los Angeles County, 2006 SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Mascola, L.; Kun, H.] Los Angeles Cty Dept Publ Hlth Acute, Communicable Dis Control Program, Los Angeles, CA USA. [Moore, A.; Steurer, F.; Lawrence, G.; Kuehnert, M.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Kubak, B.] Univ Calif Los Angeles, Los Angeles, CA USA. [Radhakrishna, S.] Univ So Calif, Los Angeles, CA USA. [Leiby, D.] Amer Red Cross, Rockville, MD USA. [Herron, R.] Amer Red Cross, Los Angeles, CA USA. [Mone, T.] One Legacy, Los Angeles, CA USA. [Hunter, R.] Calif Dept Publ Hlth, Sacramento, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD DEC PY 2008 VL 12 BP E376 EP E376 DI 10.1016/j.ijid.2008.05.994 PG 1 WC Infectious Diseases SC Infectious Diseases GA 406II UT WOS:000263287800939 ER PT J AU Murad, N Zaheen, M Asghar, RJ AF Murad, N. Zaheen, M. Asghar, R. J. TI Evaluation of the Existing Diarrhoea Surveillance System in Children Under 5 in District Peshawar, NWFP Pakistan SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Zaheen, M.] Directorate Hlth, Publ Hlth Sect, Peshawar, Pakistan. [Asghar, R. J.] Ctr Dis Control & Prevent, Atlanta, GA USA. RI Alkhalawi, Mohammed/C-6111-2012 NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD DEC PY 2008 VL 12 BP E193 EP E193 DI 10.1016/j.ijid.2008.05.479 PG 1 WC Infectious Diseases SC Infectious Diseases GA 406II UT WOS:000263287800478 ER PT J AU Safdar, RM Khan, SA Asghar, RJ AF Safdar, R. M. Khan, S. A. Asghar, R. J. TI Evaluation of Hepatitis Surveillance Systems in Pakistan SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Khan, S. A.] Natl Program Prevent & Control Hepatitis, Islamabad, Pakistan. [Asghar, R. J.] Ctr Dis Control & Prevent, Atlanta, GA USA. RI Alkhalawi, Mohammed/C-6111-2012 NR 0 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD DEC PY 2008 VL 12 BP E192 EP E192 DI 10.1016/j.ijid.2008.05.478 PG 1 WC Infectious Diseases SC Infectious Diseases GA 406II UT WOS:000263287800477 ER PT J AU Srinivasan, A AF Srinivasan, A. TI Epidemiology of Multiple-Resistant Gram-Negative Bacteria in Europe and North America SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Srinivasan, A.] CDC, Div Healthcare Qual Promot, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD DEC PY 2008 VL 12 BP E8 EP E8 DI 10.1016/j.ijid.2008.05.060 PG 1 WC Infectious Diseases SC Infectious Diseases GA 406II UT WOS:000263287800019 ER PT J AU Wiersma, BST Gacic-Dobo, M Shapiro, C AF Wiersma, B. S. T. Gacic-Dobo, M. Shapiro, C. TI Progress Towards the Global Prevention of Hepatitis SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Wiersma, B. S. T.] CDC, Atlanta, GA 30333 USA. [Gacic-Dobo, M.; Shapiro, C.] WHO, CH-1211 Geneva, Switzerland. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD DEC PY 2008 VL 12 BP E431 EP E432 DI 10.1016/j.ijid.2008.05.1262 PG 2 WC Infectious Diseases SC Infectious Diseases GA 406II UT WOS:000263287801081 ER PT J AU Kalb, SR Smith, TJ Moura, H Hill, K Lou, JL Geren, IN Garcia-Rodriguez, C Marks, JD Smith, LA Pirkle, JL Barr, JR AF Kalb, Suzanne R. Smith, Theresa J. Moura, Hercules Hill, Karen Lou, Jianlong Geren, Isin N. Garcia-Rodriguez, Consuelo Marks, James D. Smith, Leonard A. Pirkle, James L. Barr, John R. TI The use of Endopep-MS to detect multiple subtypes of botulinum neurotoxins A, B, E, and F SO INTERNATIONAL JOURNAL OF MASS SPECTROMETRY LA English DT Article DE Botulinum neurotoxin; Botulism; Mass spectrometry ID CLOSTRIDIUM-BOTULINUM; NUCLEOTIDE-SEQUENCE; MASS-SPECTROMETRY; INFANT BOTULISM; BINDING DOMAIN; ANTIBODY; TOXIN; GENE; STRAINS; CHAIN AB Botulinum neurotoxins (BoNTs) cause the disease botulism, which can be lethal if untreated. Rapid determination of exposure to BoNT is an important public health goal. Previous work in our laboratory focused on the development of Endopep-MS, a mass spectrometry-based endopeptidase method for detecting and differentiating BoNT A-G in buffer and BoNT A, B, E, and F in clinical samples. We introduce here the use of Endeopep-MS to detect non-commercial subtypes of BoNT A, B, E, and F which have been associated with botulism outbreaks. We have now tested and successfully detected 15 of the 17 known subtypes of BoNT A, B, E, and F by Endopep-MS. Extraction of BoNT A and B from a complex mixture prior to analysis is accomplished by using monoclonal antibodies specific for the catalytically inactive heavy chain of the toxin. These antibodies have high-binding affinities and do not interfere with the catalytic activity of the light chain resulting in a lower limit of detection for BoNT A and B than previously reported. We also report for the first time limits of detection for BoNT A2, A3, B2, and bivalent B using Endopep-MS. Published by Elsevier B.V. C1 [Kalb, Suzanne R.; Moura, Hercules; Pirkle, James L.; Barr, John R.] Ctr Dis Control & Prevent, NCEH, DLS, Atlanta, GA 30341 USA. [Smith, Theresa J.; Smith, Leonard A.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Hill, Karen] Los Alamos Natl Lab, Biosci Div, Los Alamos, NM 87545 USA. [Lou, Jianlong; Geren, Isin N.; Garcia-Rodriguez, Consuelo; Marks, James D.] Univ Calif San Francisco, San Francisco Gen Hosp, Dept Anesthesia & Pharmaceut Chem, San Francisco, CA 94110 USA. RP Barr, JR (reprint author), Ctr Dis Control & Prevent, NCEH, DLS, 4770 Buford Highway NE,Mailstop F-44, Atlanta, GA 30341 USA. EM jbarr@cdc.gov FU NIAID cooperative [U01 A1056493, 200-2006-16697]; CDC [200-2006-16697] FX The authors acknowledge several funding sources for the production of monoclonal antibodies: NIAID cooperative agreement U01 A1056493 (JDM), DoD contract DAMD17-03-C-0076 UDM), UC MEXUS-CONACYT Faculty Visit Fellowship (CG), and CDC contract 200-2006-16697 UDM). NR 33 TC 29 Z9 29 U1 1 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1387-3806 J9 INT J MASS SPECTROM JI Int. J. Mass Spectrom. PD DEC 1 PY 2008 VL 278 IS 2-3 BP 101 EP 108 DI 10.1016/j.ijms.2008.04.004 PG 8 WC Physics, Atomic, Molecular & Chemical; Spectroscopy SC Physics; Spectroscopy GA 378EM UT WOS:000261304000002 ER PT J AU Friedman, SR Bolyard, M Khan, M Maslow, C Sandoval, M Mateu-Gelabert, P Krauss, B Aral, SO AF Friedman, Sumuel R. Bolyard, Melissa Khan, Maria Maslow, Carey Sandoval, Milagros Mateu-Gelabert, Pedro Krauss, Beatrice Aral, Sevgi O. TI Group Sex Events and HIV/STI Risk in an Urban Network SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE group sex; HIV; sexually transmitted infections.; discordant couples; sexual networks; social networks ID SEXUALLY-TRANSMITTED-DISEASES; HIV-INFECTION; CONCURRENT PARTNERSHIPS; TRANSMISSION; MEN; BEHAVIOR; WOMEN; AIDS; METAANALYSIS; ADOLESCENTS AB Objectives: To describe: (a) the prevalence and individual and network characteristics oh group sex events (GSEs) and GSE attendees; and (b) HIV/sexually transmitted infection (STI) discordance among respondents who said they went to a GSE together. Methods and Design: In a sociometric network study of risk partners (defined as sexual partners, persons with whorl, respondents attended a GSE, or drug injection partners) in Brooklyn, NY, we recruited a high-risk sample of 465 adults. Respondents reported oil GSE attendance, the characteristics of GSEs, and their own and others' behaviors at GSEs. Sera and urines were collected, and STI prevalence was assayed. Results: Of the 465 participants, 36% had attended a GSE in the last year. 26% had sex during the most recent of these GSEs, and 13% had unprotected sex there. Certain subgroups (hard drug users, men who have sex with men, women who have sex with women, and sex workers) were more likely to attend and more likely to engage in risk behaviors at these events. Among 90 GSE dyads, in which at least I partner named the other as someone with whom they attended a GSE in the previous 3 months, STI/HIV discordance was common [herpes simplex virus (HSV-2): 45%, of dyads, HIV: 12% of dyads, and chlamydia: 21% of dyads]. Many GSEs had 10 or more participants, and multiple partnerships at GSEs were common. High attendance rates at GSEs among members of large networks may increase community vulnerability to STI/HIV particularly because network data show that almost all members of a large sociometric risk network either had sex with a GSE attendee or had sex with someone who had sex with a GSE attended. Conclusions: Self-reported GSE attendance and participation were common among this high-risk sample. STI/HIV discordance among GSE attendees was hilt, highlighting the potential transmission risk associated with GSEs. Research on sexual behaviors should incorporate measures of GSE behaviors as standard research protocol. Interventions should be developed to reduce transmission at GSEs. C1 [Friedman, Sumuel R.; Khan, Maria; Sandoval, Milagros; Mateu-Gelabert, Pedro] Natl Dev & Res Inst Inc, New York, NY 10010 USA. [Bolyard, Melissa] CUNY, Borough Manhattan Community Coll, New York, NY 10021 USA. [Khan, Maria] Publ Hlth Solut, New York, NY USA. [Maslow, Carey] New York City Dept Hlth, New York, NY 10013 USA. [Krauss, Beatrice] CUNY Hunter Coll, Ctr AIDS Drugs & Community Hlth, New York, NY 10021 USA. [Aral, Sevgi O.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Friedman, SR (reprint author), Natl Dev & Res Inst Inc, 71 W 23rd St,8th Floor, New York, NY 10010 USA. EM friedman@ndri.org FU HIV/STI Risk [R01DA013128]; Behavioral Sciences Training in Drug Abuse Research program; Public Health Solutions; National Development and Research Institutes, Inc; National Institute oil Drug Abuse [5T32 DA07233] FX Supported by the NIDA Grant Networks. Norms, and HIV/STI Risk among youth (S.R.F, Principal Investigator, R01DA013128) and by the post-doctoral Behavioral Sciences Training in Drug Abuse Research program, sponsored by Public Health Solutions and the National Development and Research Institutes, Inc with funding from the National Institute oil Drug Abuse (5T32 DA07233). NR 32 TC 31 Z9 32 U1 0 U2 14 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD DEC 1 PY 2008 VL 49 IS 4 BP 440 EP 446 DI 10.1097/QAI.0b013e3181893f31 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 371PV UT WOS:000260844300014 PM 19186355 ER PT J AU Latkin, CA Buchanan, AS Metsch, LR Knight, K Latka, MH Mizuno, Y Knowlton, AR AF Latkin, Carl A. Buchanan, Amy S. Metsch, Lisa R. Knight, Kelly Latka, Mary H. Mizuno, Yarko Knowlton, Amy R. CA Intervention Seropositive Injector TI Predictors of Sharing Injection Equipment by HIV-Seropositive Injection Drug Users SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE Medical care; HIV seropositives; injection drug users; social norms; sharing injection equipment; psychological distress ID 5 US CITIES; RISK BEHAVIORS; INFECTION; TRANSMISSION AB Among HIV-positive injection drug users (IDUs). we examined baseline predictors of lending needles and syringes and sharing cookers. cotton. and rinse water in the prior 3 months at follow-up. Participants were enrolled in Intervention for Seropositive Injectors-Research and Evaluation, a secondary prevention intervention for sexually active HIV positive IDUs in 4 US cities during 2001-2005. The analyses involved 357 participants who reported injecting drugs in the prior 6 months at either the 6- or 12-month follow-up visit. About half (=t9%) reported at least I sharing episode. In adjusted analyses, peer norms supporting safer injection practices and having primary HIV medical care visits in the prior 6 months were associated with reporting no sharing of injection equipment. Higher levels of psychological distress were associated with a greater likelihood of reporting drug paraphernalia sharing. These findings suggest that intervention approaches for reducing HIV seropositive IDUs' transmission of blood-borne infections should include peer-focused interventions to alter nouns of drug paraphernalia sharing and promoting primary HIV care and mental health services. C1 [Latkin, Carl A.; Knowlton, Amy R.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Behav & Soc, Baltimore, MD 21205 USA. [Buchanan, Amy S.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD 21205 USA. [Metsch, Lisa R.] Univ Miami, Leonard M Miller Sch Med, Dept Epidemiol & Publ Hlth, Miami, FL USA. [Knight, Kelly] Univ Calif San Francisco, AIDS Res Inst, San Francisco, CA 94143 USA. [Latka, Mary H.] Aurum Inst Hlth Res, Johannesburg, South Africa. [Mizuno, Yarko] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV STD & TB Prevent, Atlanta, GA USA. RP Latkin, CA (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Behav & Soc, 624 N Broadway,Room 737, Baltimore, MD 21205 USA. EM clatkin@jhsph.edu RI Bohnert, Amy/C-7313-2015; OI Coffin, Phillip/0000-0002-3891-6570 FU Centers for Disease Control and Prevention FX The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 20 TC 15 Z9 15 U1 2 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD DEC 1 PY 2008 VL 49 IS 4 BP 447 EP 450 DI 10.1097/QAI.0b013e31818a6546 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 371PV UT WOS:000260844300015 PM 19186356 ER PT J AU Kidder, DP Wolitski, RJ Pals, SL Campsmith, ML AF Kidder, Daniel P. Wolitski, Richard J. Pals, Sherri L. Campsmith, Michael L. TI Housing Status and HIV Risk Behaviors Among Homeless and Housed Persons With HIV SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE housing; homelessness; HIV risk; sexual risk; drug risk ID AIDS SURVEILLANCE; HEALTH-CARE; PREVENTION; EPIDEMIC; ACCESS; POLICY; WOMEN AB Objectives: To compare drug. alcohol, and sexual HIV transmission risk behaviors of homeless and housed people living with HIV/AIDS. Methods: Data were from 8075 respondents in a cross-sectional. multisite behavioral survey of adults recently reported to have HIV infection. Results: At interview, 310 respondents (4%) were homeless. Compared with homeless respondents, housed respondents were more likely to be sexually active (past 12 months). However, sexually active homeless respondents had more sex partners (lifetime and past 12 months), greater sex exchange for money or drugs (lifetime and past 12 months). and greater unprotected vaginal or anal sex with an unknown serostatus partner. Homeless respondents were more likely to have possible alcohol abuse (lifetime), used drugs (last 12 months), and injected drugs (lifetime and past 12 months). After controlling for potential confounding variables, housing status remained a significant predictor of number of sex partners (past 12 months). sex exchange (lifetime and past 12 months), unprotected sex with unknown status partner. and all drug and alcohol use variables. Conclusions: Homeless people living with HIV/AIDS are more likely to have ever or recently engaged in substance use and HIV transmission risk behaviors. Findings underscore the need to provide HIV prevention services to homeless persons and address their housing needs. C1 [Kidder, Daniel P.; Wolitski, Richard J.; Pals, Sherri L.; Campsmith, Michael L.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. RP Kidder, DP (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, 1600 Clifton Rd,Mailstop E-04, Atlanta, GA 30333 USA. EM dkidder@cdc.gov FU Centers for Disease Control and Prevention FX The findings and conclusions in this article are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 17 TC 29 Z9 29 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD DEC 1 PY 2008 VL 49 IS 4 BP 451 EP 455 DI 10.1097/QAI.0b013e31818a652c PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 371PV UT WOS:000260844300016 PM 19186357 ER PT J AU Sejvar, JJ Schonberger, LB Belay, ED AF Sejvar, James J. Schonberger, Lawrence B. Belay, Ermias D. TI Transmissible spongiform encephalopathies SO JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION LA English DT Article ID CHRONIC WASTING DISEASE; CREUTZFELDT-JAKOB-DISEASE; WHITE-TAILED DEER; PRION DISEASES; MULE DEER; INTRACEREBRAL INOCULATION; MINK ENCEPHALOPATHY; TRANSGENIC MICE; SURVEILLANCE PROGRAM; SPECIES BARRIERS C1 [Sejvar, James J.; Schonberger, Lawrence B.; Belay, Ermias D.] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Natl Ctr Zoonot Vectorborne & Enter Dis, Atlanta, GA 30333 USA. RP Sejvar, JJ (reprint author), Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Natl Ctr Zoonot Vectorborne & Enter Dis, 1600 Clifton Rd, Atlanta, GA 30333 USA. RI Belay, Ermias/A-8829-2013 NR 78 TC 5 Z9 5 U1 1 U2 11 PU AMER VETERINARY MEDICAL ASSOC PI SCHAUMBURG PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA SN 0003-1488 J9 JAVMA-J AM VET MED A JI JAVMA-J. Am. Vet. Med. Assoc. PD DEC 1 PY 2008 VL 233 IS 11 BP 1705 EP 1712 DI 10.2460/javma.233.11.1705 PG 8 WC Veterinary Sciences SC Veterinary Sciences GA 376UY UT WOS:000261209700016 PM 19046027 ER PT J AU Chatters, LM Taylor, RJ Bullard, KM Jackson, JS AF Chatters, Linda M. Taylor, Robert Joseph Bullard, Kai M. Jackson, James S. TI Spirituality and Subjective Religiosity Among African Americans, Caribbean Blacks, and Non-Hispanic Whites SO JOURNAL FOR THE SCIENTIFIC STUDY OF RELIGION LA English DT Article ID HEALTH; ADULTS AB Patterns and correlates of self-perceptions of spirituality and subjective religiosity are examined using data from the National Survey of American Life, a nationally representative study of African Americans, Caribbean blacks, and non-Hispanic whites. Demographic and denominational correlates of patterns of subjective religiosity and spirituality (i.e., religious only, spiritual only, both religious/spiritual, and neither religious/spiritual) are examined. In addition, the study of African Americans and Caribbean blacks permits the investigation of possible ethnic variation in the meaning and conceptual significance of these constructs within the U.S. black population. African Americans and Caribbean blacks are more likely than non-Hispanic whites to indicate that they are "both religious and spiritual" and less likely to indicate that they are "spiritual only" or "neither spiritual nor religious." Demographic and denominational differences in the patterns of spirituality and subjective religiosity are also indicated. Study findings are discussed in relation to prior research in this field and conceptual and methodological issues deserving further study are noted. C1 [Chatters, Linda M.] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA. [Chatters, Linda M.; Taylor, Robert Joseph] Univ Michigan, Sch Social Work, Ann Arbor, MI 48109 USA. [Bullard, Kai M.] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA USA. [Jackson, James S.] Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA. [Jackson, James S.] Univ Michigan, Inst Social Res, Ann Arbor, MI 48109 USA. RP Chatters, LM (reprint author), 109 Observ St, Ann Arbor, MI 48109 USA. EM chatters@umich.edu; rjtaylor@umich.edu; hjo1@cdc.gov; jamessj@umich.edu FU NIA NIH HHS [P30 AG015281, P30 AG015281-10, R01 AG018782, R01 AG018782-05]; NIMH NIH HHS [U01 MH057716] NR 29 TC 26 Z9 26 U1 1 U2 9 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0021-8294 J9 J SCI STUD RELIG JI J. Sci. Stud. Relig. PD DEC PY 2008 VL 47 IS 4 BP 725 EP 737 DI 10.1111/j.1468-5906.2008.00437.x PG 13 WC Sociology; Religion SC Sociology; Religion GA 374UJ UT WOS:000261068900014 PM 21052481 ER PT J AU McCauley, MM Stokley, S Stevenson, J Fishbein, DB AF McCauley, Mary Mason Stokley, Shannon Stevenson, John Fishbein, Daniel B. TI Adolescent Vaccination: Coverage Achieved by Ages 13-15 Years, and Vaccinations Received as Recommended During Ages 11-12 Years, National Health Interview Survey 1997-2003 SO JOURNAL OF ADOLESCENT HEALTH LA English DT Article DE Immunization assessment; Adolescence ID HUMAN-PAPILLOMAVIRUS VACCINE; IMMUNIZATION PRACTICES ACIP; UNITED-STATES; ADVISORY-COMMITTEE; CHILDREN; CARE; PEDIATRICIANS; PHYSICIANS; SYSTEM; VISIT AB Purpose: To present progress toward Healthy People 2010 vaccination objectives for adolescents aged 13-15 years, and to determine how much catch-up and routine vaccination was administered at the recommended ages of 11-12 years. Methods: Data from the 1997-2003 National Health Interview Survey were evaluated. In the first analysis, vaccination coverage levels for adolescents aged 13-15 years were determined for each survey year. Main outcome measures include the percent of adolescents who had received the three-dose hepatitis B vaccine (Hep B) series. the two-dose measles/mumps/rubella vaccine (MMR) series, the tetanus and diphtheria toxoids (Td) booster, and one dose of varicella vaccine. In the second analysis, data from all survey years were combined and vaccination dates were analyzed to determine the percentage of adolescents who were missing any vaccines at ages 11-12 and received them at that age. Data for varicella vaccine were sufficient only for the first analysis. Results: Among the approximately 15%-20% of respondents who reported vaccination history from records in the home and who were reporting on a 13-15-year-old, coverage with three doses of Hep B increased significantly during 1997-2001, from 15.2% to 55.0%. Coverage with MMR and Td fluctuated, with no significant increase; highs were 76.7% for MMR in 2003 and 36.2% for Td in 2002. Examination of vaccination dates for all surveyed adolescents showed that among 11-12-year-olds who needed catch-up vaccine, 0.6%-31.3% were brought up to date for Hep B and 22.1%-31.8% were brought up to date for MMR. For Td. 2.6%-15.4% of 11-12-year-olds who had not previously received Td received the vaccine. Conclusion: Vaccination coverage among adolescents aged 13-15 years was below the Healthy People 2010 goals of 90%, but generally increased over the survey years. However, the suboptimal delivery of needed vaccines during ages 11 and 12 is concerning in light of recent vaccine recommendations targeted at this age. Continuing to focus on strategies to make adolescent preventive care, including vaccination, a new norm is essential. (c) 2008 Society for Adolescent Medicine. All rights reserved. C1 [McCauley, Mary Mason; Stokley, Shannon; Stevenson, John; Fishbein, Daniel B.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP McCauley, MM (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,MS E-05, Atlanta, GA 30333 USA. EM MNcCiuley@cdc.gov NR 36 TC 11 Z9 11 U1 2 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD DEC PY 2008 VL 43 IS 6 BP 540 EP 547 DI 10.1016/j.jadohealth.2009.09.002 PG 8 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA 382RQ UT WOS:000261623500005 PM 19027641 ER PT J AU Wang, Z Hopke, PK Ahmadi, G Cheng, YS Baron, PA AF Wang, Zuocheng Hopke, Philip K. Ahmadi, Goodarz Cheng, Yung-Sung Baron, Paul A. TI Fibrous particle deposition in human nasal passage: The influence of particle length, flow rate, and geometry of nasal airway SO JOURNAL OF AEROSOL SCIENCE LA English DT Article DE Nasal deposition; Glass fiber; Realistic nasal model; Relaxation time; Particle deposition efficiency; Pressure drop; Friction coefficient ID MADE VITREOUS FIBERS; AEROSOL; MODEL; MORTALITY; WORKERS AB Man-made vitreous fibers (MMVFs) have been used as a substitute for asbestos in industrial and residential applications. This shift has raised the concerns of the potential hazards associated with inhalation of these fibers. The human nose is an important protective organ that captures harmful particles and then clears them from human respiratory tract. However, studies have shown that some or even most of the inhalable fibrous particles can penetrate human nose and deposit into the deep lung. The understanding of fibrous particle deposition in the human nasal passage has important occupational health and possible drug delivery applications. To study the deposition pattern and influential factors, three realistic human nasal models were used and a dielectrophoretic classifier was applied to generate test aerosol of glass fibers with a narrow length distribution. These models were made by using stereolithography based on MRI data from two human subjects. Regional and total deposition efficiencies were measured for five different flow rates: 4, 8, 12, 15, and 18 Lpm and four different fiber length ranges: 10-19. 20-29, 30-39, and 40-49 mu m. This study found that deposition of glass fibers (with about 1 mu m diameter) in human nasal passage is mainly due to inertial impaction and these fibers orientated themselves normal to the flow direction before deposition occurs. An effective aerodynamic diameter is defined such that the deposition efficiencies of glass fibers are comparable with those of spherical particles. Non-dimensional parameters were defined and an empirical model based on the experimental results is proposed to calculate fibrous particle deposition efficiency in human nose. Empirical expressions were also developed to estimate the pressure drop across the nasal model. Thus, empirical equations are now available for the prediction of total deposition in the human nasal tract for the fibrous particles under constant inspiring flow rates. In addition, this study suggested that these equations can also be used to predict the deposition of spherical particles. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Wang, Zuocheng; Hopke, Philip K.; Ahmadi, Goodarz] Clarkson Univ, Ctr Air Resources Engn & Sci, Potsdam, NY 13676 USA. [Cheng, Yung-Sung] Lovelace Resp Res Inst, Albuquerque, NM USA. [Baron, Paul A.] NIOSH, Cincinnati, OH 45226 USA. RP Hopke, PK (reprint author), Clarkson Univ, Ctr Air Resources Engn & Sci, Potsdam, NY 13676 USA. EM hopkepk@clarkson.edu RI Hopke, Philip/C-6020-2008 OI Hopke, Philip/0000-0003-2367-9661 FU National Institute for Occupational Health and Safety [R01 OH003900] FX This research is supported by the National Institute for Occupational Health and Safety through Grant R01 OH003900. The authors would like to thank Mr. Gregory Deye at National Institute for Occupational Safety and Health for valuable discussions and suggestions. The authors also appreciate Mr. Douglas Leonard's work in the manufacture of the nasal models. NR 40 TC 15 Z9 16 U1 1 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0021-8502 J9 J AEROSOL SCI JI J. Aerosol. Sci. PD DEC PY 2008 VL 39 IS 12 BP 1040 EP 1054 DI 10.1016/j.jaerosci.2008.07.008 PG 15 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 385XE UT WOS:000261846100003 ER PT J AU Biggerstaff, BJ AF Biggerstaff, Brad J. TI Confidence Intervals for the Difference of Two Proportions Estimated From Pooled Samples SO JOURNAL OF AGRICULTURAL BIOLOGICAL AND ENVIRONMENTAL STATISTICS LA English DT Article DE Binomial; Group testing; Profile likelihood; Profile score; Score; West Nile virus ID ESTIMATING PREVALENCE; INFECTION-RATES; POPULATIONS; SIZE AB This article presents confidence intervals for the difference of two binomial proportions estimated from pooled samples with unequal pool sizes. Asymptotic methods are used to derive Wald, profile score, and profile likelihood ratio intervals. Corrections for bias and skewness of the distribution of the Studentized score statistic are used to improve the profile score interval. Further, the easily computed Wilson score-based interval of Newcombe is adapted. Coverage and noncoverage probabilities and expected lengths of the confidence intervals are estimated for a range of parameter values expected in application, for both one- and two-sample cases. The skewness-corrected profile score interval is generally recommended. The methods are applied to a comparison of West Nile virus mosquito infection prevalences by trapping height in field collections from Louisiana in 2003. C1 Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Ft Collins, CO 80521 USA. RP Biggerstaff, BJ (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, 3150 Rampart Rd, Ft Collins, CO 80521 USA. EM BBiggerstaff@edc.gov NR 22 TC 19 Z9 19 U1 0 U2 5 PU AMER STATISTICAL ASSOC & INT BIOMETRIC SOC PI WASHINGTON PA 1444 I ST NW, STE 700, WASHINGTON, DC 20005 USA SN 1085-7117 J9 J AGR BIOL ENVIR ST JI J. Agric. Biol. Environ. Stat. PD DEC PY 2008 VL 13 IS 4 BP 478 EP 496 DI 10.1198/108571108X379055 PG 19 WC Biology; Mathematical & Computational Biology; Statistics & Probability SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational Biology; Mathematics GA 374VN UT WOS:000261071900007 ER PT J AU Mensah, GA AF Mensah, George A. TI High Blood Pressure in Children and Adolescents: To Treat or Not to Treat Is Not the Question SO JOURNAL OF CLINICAL HYPERTENSION LA English DT Editorial Material ID AMERICAN-HEART-ASSOCIATION; LEFT-VENTRICULAR HYPERTROPHY; PROMOTING PHYSICAL-ACTIVITY; CHILDHOOD RISK-FACTORS; CARDIOVASCULAR-DISEASE; SCIENTIFIC STATEMENT; LEADERSHIP ROLE; YOUTH; HYPERTENSION; ATHEROSCLEROSIS C1 Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Mensah, GA (reprint author), Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Mailstop K-40,4770 Buford Highway NE, Atlanta, GA 30341 USA. EM gmensah@cdc.gov OI Mensah, George/0000-0002-0387-5326 NR 27 TC 1 Z9 1 U1 0 U2 1 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1524-6175 J9 J CLIN HYPERTENS JI J. Clin. Hypertens. PD DEC PY 2008 VL 10 IS 12 BP 889 EP 893 DI 10.1111/j.1751-7176.2008.00056.x PG 5 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 385UB UT WOS:000261838000001 PM 19120714 ER PT J AU Vawter, L Tong, X Gemilyan, M Yoon, PW AF Vawter, Lemuel Tong, Xin Gemilyan, Manik Yoon, Paula W. TI Barriers to Antihypertensive Medication Adherence Among Adults-United States, 2005 SO JOURNAL OF CLINICAL HYPERTENSION LA English DT Article ID BLOOD-PRESSURE CONTROL; HYPERTENSION; PREVALENCE; PERSISTENCE; AWARENESS; THERAPY AB Antihypertensive agents are one of the most commonly prescribed classes of medications in the country, but patient adherence rates are low. To better understand why rates are low, the authors used data from the 2005 HealthStyles survey and found that among the 1432 respondents who received prescriptions for antihypertensive medications, 407 (28.4%) reported having difficulty taking their medication. "Not remembering" was the most common reason reported (32.4%), followed by cost (22.6%), having no insurance (22.4%), side effects (12.5%), other reasons (12.3%), not thinking there is any need (9.3%), and having no health care provider (4.7%). In a multivariate model, younger age, lower income, having menta function impairment, and having bad a blood pressure check more than 6 months earlier were factors significantly associated with reporting difficulty taking prescribed antihypertensive drugs. Control of hypertension is a significant public health issue, and alleviating barriers to medication adherence should be a major goal toward hypertension management. J Clin Hypertens (Greenwich). 2008;10:922-929. (c) 2008 Le Jacq C1 [Vawter, Lemuel; Tong, Xin; Gemilyan, Manik; Yoon, Paula W.] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA 30341 USA. RP Yoon, PW (reprint author), Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, 4770 Buford Highway,MS K47, Atlanta, GA 30341 USA. EM pyoon@cdc.gov NR 21 TC 30 Z9 33 U1 0 U2 2 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1524-6175 J9 J CLIN HYPERTENS JI J. Clin. Hypertens. PD DEC PY 2008 VL 10 IS 12 BP 922 EP 929 DI 10.1111/j.1751-7176.2008.00049.x PG 8 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 385UB UT WOS:000261838000005 PM 19120718 ER PT J AU Sriram, R Shoff, M Booton, G Fuerst, P Visvesvara, GS AF Sriram, Rama Shoff, Megan Booton, Gregory Fuerst, Paul Visvesvara, Govinda S. TI Survival of Acanthamoeba Cysts after Desiccation for More than 20 Years SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID FREE-LIVING AMEBAS; GENUS ACANTHAMOEBA; IDENTIFICATION; DISINFECTION; KERATITIS; HUMANS; SPP.; VIABILITY; SLUDGE; AGENTS AB Acanthamoeba is a free-living ameba that is found throughout the world and that causes encephalitis, keratitis, and cutaneous infections in humans. It has two stages in its life cycle: a trophic stage and a resistant cyst stage. We describe here the ability of Acanthamoeba cysts to survive desiccation for more than 20 years. C1 [Sriram, Rama; Visvesvara, Govinda S.] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA 30341 USA. [Shoff, Megan; Booton, Gregory; Fuerst, Paul] Ohio State Univ, Dept Mol Genet & Evolut, Columbus, OH 43210 USA. [Shoff, Megan; Booton, Gregory; Fuerst, Paul] Ohio State Univ, Dept Ecol, Columbus, OH 43210 USA. [Shoff, Megan; Booton, Gregory; Fuerst, Paul] Ohio State Univ, Dept Organismal Biol, Columbus, OH 43210 USA. RP Visvesvara, GS (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis, MS F36,Chamblee Campus,4470 Buford Highway NE, Atlanta, GA 30341 USA. EM gsv1@cdc.gov FU Public Health Service [EY09073]; National Eye Institute FX The work of Megan Shoff, Gregory C. Booton, and Paul Fuerst was supported by Public Health Service grant EY09073 awarded to P. F. by the National Eye Institute. NR 27 TC 28 Z9 29 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD DEC PY 2008 VL 46 IS 12 BP 4045 EP 4048 DI 10.1128/JCM.01903-08 PG 4 WC Microbiology SC Microbiology GA 377JQ UT WOS:000261247900029 PM 18923013 ER PT J AU Lo, MK Rota, PA AF Lo, Michael K. Rota, Paul A. TI The emergence of Nipah virus, a highly pathogenic paramyxovirus SO JOURNAL OF CLINICAL VIROLOGY LA English DT Article DE Nipah virus; Encephalitis; Outbreak; Bangladesh; India ID SUBACUTE SCLEROSING-PANENCEPHALITIS; HENDRA-VIRUS; ESCHERICHIA-COLI; NUCLEOCAPSID PROTEIN; MOLECULAR CHARACTERIZATION; MONOCLONAL-ANTIBODIES; DEADLY PARAMYXOVIRUS; PTEROPID BATS; FLYING-FOXES; RT-PCR AB Nipah virus first emerged in Malaysia and Singapore between 1998 and 1999, causing severe febrile encephalitis in humans with a mortality rate of close to 40%. In addition, a significant portion of those recovering from acute infection had relapse encephalitis and long-term neurological defects. Since its initial outbreak, there have been numerous Outbreaks in Bangladesh and India, in which the mortality rate rose to approximately 70%. These Subsequent outbreaks were distinct From the initial outbreak, both in their epidemiology and in their clinical presentations. Recent developments in diagnostics may expedite disease diagnosis and outbreak containment, while progress ill Understanding the molecular biology of Nipah virus could lead to novel therapeutics and vaccines for this deadly pathogen. Published by Elsevier B.V. C1 [Lo, Michael K.; Rota, Paul A.] Ctr Dis Control & Prevent, Measles Mumps Rubella & Herpesviruses Lab Branch, Atlanta, GA 30333 USA. [Lo, Michael K.] Emory Univ, Dept Microbiol & Immunol, Atlanta, GA 30322 USA. RP Rota, PA (reprint author), Ctr Dis Control & Prevent, Measles Mumps Rubella & Herpesviruses Lab Branch, 1600 Clifton Rd,Mailstop C-22, Atlanta, GA 30333 USA. EM par1@cdc.gov OI Lo, Michael/0000-0002-0409-7896 NR 83 TC 57 Z9 58 U1 0 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1386-6532 J9 J CLIN VIROL JI J. Clin. Virol. PD DEC PY 2008 VL 43 IS 4 BP 396 EP 400 DI 10.1016/j.jcv.2008.08.007 PG 5 WC Virology SC Virology GA 384MY UT WOS:000261750100009 PM 18835214 ER PT J AU Courtenay-Quirk, C Pals, SL Kidder, DP Henny, K Emshoff, JG AF Courtenay-Quirk, Cari Pals, Sherri L. Kidder, Daniel P. Henny, Kirk Emshoff, James G. TI Factors Associated With Incarceration History Among HIV-Positive Persons Experiencing Homelessness or Imminent Risk of Homelessness SO JOURNAL OF COMMUNITY HEALTH LA English DT Article DE Incarceration; HIV; AIDS; Homelessness; Health status; Risk behavior ID FACE-TO-FACE; HEALTH; BEHAVIOR; ACCESS; ARREST; CARE AB Among persons living with HIV/AIDS (PLWHA) experiencing homelessness or imminent risk of homelessness, a history of incarceration may serve as a marker for ongoing risk behavior or health disparities. We examined factors associated with a history of incarceration among HIV-positive clients of housing agencies in Baltimore, Chicago, and Los Angeles (N = 581). We used logistic regression to conduct analyses. Of the 581 participants, 68% (n = 438) reported a history of incarceration: 32% (n = 182) had spent more than 1 year incarcerated. After adjustment for covariates, incarceration history was associated with having ever injected drugs, ever engaged in sex exchange, and ever experienced physical abuse. Incarceration history was also associated with having a detectable HIV viral load, better mental health, and being a biological parent. It was not associated with current risk behavior. Service providers may explore possible increased need for medical support among homeless PLWHA with a history of incarceration. C1 [Courtenay-Quirk, Cari; Pals, Sherri L.; Henny, Kirk] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. [Kidder, Daniel P.] Ctr Dis Control & Prevent, Global AIDS Program, Atlanta, GA 30333 USA. [Emshoff, James G.] Georgia State Univ, Dept Psychol, Atlanta, GA 30302 USA. RP Courtenay-Quirk, C (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, 1600 Clifton Rd,NE,Mailstop E-37, Atlanta, GA 30333 USA. EM Ccourtenayquirk@cdc.gov OI Henny, Kirk/0000-0002-0886-8651 NR 32 TC 12 Z9 13 U1 1 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0094-5145 J9 J COMMUN HEALTH JI J. Community Health PD DEC PY 2008 VL 33 IS 6 BP 434 EP 443 DI 10.1007/s10900-008-9115-7 PG 10 WC Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA 358IT UT WOS:000259911100009 PM 18581214 ER PT J AU Blake, R AF Blake, Rob TI Enhancing and Revitalizing Environmental Public Health SO JOURNAL OF ENVIRONMENTAL HEALTH LA English DT Editorial Material C1 CDC, Div Emergency & Environnm Hlth Serv, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. RP Blake, R (reprint author), CDC, Div Emergency & Environnm Hlth Serv, Natl Ctr Environm Hlth, 4770 Buford Highway,NE,MS F-60, Atlanta, GA 30341 USA. EM rgblake@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATL ENVIRON HEALTH ASSOC PI DENVER PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA SN 0022-0892 J9 J ENVIRON HEALTH JI J. Environ. Health PD DEC PY 2008 VL 71 IS 5 BP 46 EP 47 PG 2 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 379MK UT WOS:000261400200008 PM 19115723 ER PT J AU Middleton, D Sowell, A Uddin, M Shim, Y AF Middleton, Dan Sowell, Anne Uddin, Mohammed Shim, Youn TI Community Testing: A Commentary SO JOURNAL OF ENVIRONMENTAL HEALTH LA English DT Editorial Material ID VERMICULITE MINERS; MORTALITY; TREMOLITE; BELPT C1 [Middleton, Dan] CDC, ATSDR, Atlanta, GA 30341 USA. RP Middleton, D (reprint author), CDC, ATSDR, Mailstop F-57,4770 Buford Highway NE, Atlanta, GA 30341 USA. EM dem2@cdc.gov NR 7 TC 0 Z9 0 U1 0 U2 0 PU NATL ENVIRON HEALTH ASSOC PI DENVER PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA SN 0022-0892 J9 J ENVIRON HEALTH JI J. Environ. Health PD DEC PY 2008 VL 71 IS 5 BP 48 EP 49 PG 2 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 379MK UT WOS:000261400200009 PM 19115724 ER PT J AU Ailes, EC Leon, JS Jaykus, LA Johnston, LM Clayton, HA Blanding, S Kleinbaum, DG Backer, LC Moe, CL AF Ailes, Elizabeth C. Leon, Juan S. Jaykus, Lee-Ann Johnston, Lynette M. Clayton, Haley A. Blanding, Sarah Kleinbaum, David G. Backer, Lorraine C. Moe, Christine L. TI Microbial Concentrations on Fresh Produce Are Affected by Postharvest Processing, Importation, and Season SO JOURNAL OF FOOD PROTECTION LA English DT Article ID ESCHERICHIA-COLI; MICROBIOLOGICAL QUALITY; MULTISTATE OUTBREAK; CONSUMPTION; SALMONELLA; CONTAMINATION; CANTALOUPE; VEGETABLES; LETTUCE; FARMERS AB In the United States, the proportion of foodborne illness Outbreaks associated with consumption of contaminated domestic and imported fresh fruits and vegetables (produce) has increased over the past several decades. To address this public health concern. the coal of this work was to identify and quantify factors associated with microbial contamination of produce in pre- and postharvest phases of the farm-to-fork continuum. From 2000 to 2003, we collected 923 samples of 14 types of produce (grown in the southern United States or in the northern border states of Mexico) from 15 farms and eight packing sheds located in the southern United States. To assess microbial quality, samples were enumerated for Escherichia coli, total aerobic bacteria. total coliforms, and total Enterococcus. Most produce types had significantly higher microbial concentrations when sampled at the packing shed than when sampled at the farm. In addition, we observed seasonal differences in the microbial concentrations on samples grown in the United States. with higher mean indicator concentrations detected in the fall (September. October. and November). We developed a predictive, multivariate logistic regression model to identify and quantify factors that were associated with detectable concentrations of E. coli contamination on produce. These factors included produce type (specifically, cabbage or cantaloupe), season of collection (harvested in the fall), and packing step (bin, box. conveyor belt, or turntable). These results can be used to identify specific mechanisms of produce contamination and propose interventions that may decrease the likelihood of produce-associated illness. C1 [Leon, Juan S.; Clayton, Haley A.; Blanding, Sarah; Moe, Christine L.] Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA 30322 USA. [Ailes, Elizabeth C.; Kleinbaum, David G.] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA. [Jaykus, Lee-Ann; Johnston, Lynette M.] N Carolina State Univ, Dept Food Sci, Coll Agr & Life Sci, Raleigh, NC 27607 USA. [Backer, Lorraine C.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Chamblee, GA 30341 USA. RP Moe, CL (reprint author), Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA 30322 USA. EM clmoe@sph.emory.edu RI Moe, Christine/G-6118-2012; Leon, Juan/E-9674-2012 FU U.S. Department of Agriculture; Cooperative State Research, Education, and Extension Service; National Research Initiative; Epidemiological Approaches to Food Safety Program [99-35212-8564, 2002-35212-12386]; Cooperative State Research, Education, and Extension Service Food Science National Needs [00-38420-8802]; U.S. Food and Drug Administration-Joint Institute for Food Safety and Applied Nutrition [FD-U-001418] FX The authors gratefully acknowledge U.S. Department of Agriculture, Cooperative State Research, Education, and Extension Service, National Research Initiative, Epidemiological Approaches to Food Safety Program, award nos. 99-35212-8564 and 2002-35212-12386 for support of this work. Author L. M. Johnston was provided funding through a U.S. Department of Agriculture, Cooperative State Research, Education, and Extension Service Food Science National Needs fellowship to North Carolina State University, no. 00-38420-8802. Author J. S. Leon was provided funding through U.S. Food and Drug Administration-Joint Institute for Food Safety and Applied Nutrition grant no. FD-U-001418. and a post-doctoral fellowship from the Irvington-Dana Institutes. NR 38 TC 37 Z9 37 U1 1 U2 17 PU INT ASSOC FOOD PROTECTION PI DES MOINES PA 6200 AURORA AVE SUITE 200W, DES MOINES, IA 50322-2863 USA SN 0362-028X J9 J FOOD PROTECT JI J. Food Prot. PD DEC PY 2008 VL 71 IS 12 BP 2389 EP 2397 PG 9 WC Biotechnology & Applied Microbiology; Food Science & Technology SC Biotechnology & Applied Microbiology; Food Science & Technology GA 380NR UT WOS:000261472900002 PM 19244889 ER PT J AU Kempe, A Hurley, L Stokley, S Daley, MF Crane, LA Beaty, BL Dickinson, LM Babbel, C Barrow, J Steiner, JF AF Kempe, Allison Hurley, Laura Stokley, Shannon Daley, Matthew F. Crane, Lori A. Beaty, Brenda L. Dickinson, L. Miriam Babbel, Christine Barrow, Jennifer Steiner, John F. TI Pneumococcal Vaccination in General Internal Medicine Practice: Current Practice and Future Possibilities SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Article; Proceedings Paper CT 29th Annual Meeting of the Society-of-General-Internal-Medicine CY APR 26-29, 2006 CL Los Angeles, CA SP Soc Gen Internal Med DE immunization delivery; pneumococcal vaccine; pneumococcus pneumonia ID COST-EFFECTIVENESS; UNITED-STATES; ADULTS; POLYSACCHARIDE; IMMUNIZATION; INFLUENZA; RECOMMENDATIONS; INTERVENTIONS; COVERAGE; DISEASE AB BACKGROUND: Pneumococcal vaccine (PPV) is recommended for adults >= 65 years and those with chronic illness, but there are potential advantages of universal vaccination of adults age 50-64 years. OBJECTIVE: To assess reported (1) recommendations and administration practices of general internists for PPV, (2) barriers to vaccination, and (3) willingness to expand vaccination to all adults >= 50 years. METHODS: National survey of general internists representative of the American College of Physicians. RESULTS: Response rate was 74% (N = 326). Although 99% reported giving PPV, less than 20% used a computerized database to identify eligible patients by age or diagnoses and only 6% recalled patients. Major barriers included acute problems taking precedence over preventive care (39%), difficulty determining vaccination history (30%), not thinking of it/not a priority (20%), and inadequate reimbursement for vaccine (19%). If ACIP expanded recommendations, 60% would definitely and 37% would probably institute this change. CONCLUSIONS: Most general internists reported giving PPV, but delivery was hindered by competing demands, lack of systems to identify patients needing vaccination, and reimbursement issues. Barriers might be decreased by a policy of universal vaccination of adults >= 50 years, and the majority of physicians reported they would follow such a recommendation if it were made. C1 [Kempe, Allison; Stokley, Shannon] Univ Colorado, Dept Pediat, Denver, CO 80202 USA. [Kempe, Allison; Daley, Matthew F.; Crane, Lori A.; Beaty, Brenda L.; Steiner, John F.] Univ Colorado, Colorado Hlth Outcomes Program, Denver, CO 80202 USA. [Kempe, Allison; Daley, Matthew F.; Crane, Lori A.; Beaty, Brenda L.; Babbel, Christine; Barrow, Jennifer] Childrens Hosp, Childrens Outcomes Res Program, Denver, CO 80218 USA. [Hurley, Laura] Univ Colorado, Hlth Sci Ctr, Div Gen Internal Med, Denver, CO 80262 USA. [Stokley, Shannon] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Kempe, A (reprint author), 12477 E 19th Ave,Mailstop F443, Aurora, CO 80045 USA. EM Kempe.allison@tchden.org FU NCCDPHP CDC HHS [5 U48 DP000054-03, U48 DP000054] NR 19 TC 8 Z9 8 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD DEC PY 2008 VL 23 IS 12 BP 2010 EP 2013 DI 10.1007/s11606-008-0800-0 PG 4 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA 379VJ UT WOS:000261424000012 PM 18830765 ER PT J AU Currie, J Decker, S Lin, WC AF Currie, Janet Decker, Sandra Lin, Wanchuan TI Has public health insurance for older children reduced disparities in access to care and health outcomes? SO JOURNAL OF HEALTH ECONOMICS LA English DT Article DE Medicaid; Children's health ID ELIGIBILITY; CHILDHOOD; INCOME; BRAIN AB This paper investigates the effects of expanding public health insurance eligibility for older children. Using data from the National Health Interview Surveys from 1986 to 2005, we first show that although income continues to be an important predictor of children's health status, the importance of income for predicting health has fallen for children 9-17 in recent years. We then investigate the extent to which the dramatic expansions in public health insurance coverage for these children in the past decade are responsible for the decline in the importance of income. We find that while eligibility for public health insurance unambiguously improves current utilization of preventive care, it has little effect on current health status. However, we find some evidence that Medicaid eligibility in early childhood has positive effects on future health. This may indicate that adequate medical care early on puts children on a better health trajectory, resulting in better health as they grow. (C) 2008 Elsevier B.V. All rights reserved. C1 [Currie, Janet] Columbia Univ, Dept Econ, New York, NY 10027 USA. [Currie, Janet] NBER, Cambridge, MA 02138 USA. [Decker, Sandra] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Lin, Wanchuan] Peking Univ, Guanghua Sch Management, Beijing 100871, Peoples R China. RP Currie, J (reprint author), Columbia Univ, Dept Econ, 1014 Int Affairs Bldg,MC 3308,420 W 118th St, New York, NY 10027 USA. EM Janet.Currie@columbia.edu; SDecker@cdc.gov; WLin@gsm.pku.edu.cn NR 25 TC 55 Z9 55 U1 4 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-6296 J9 J HEALTH ECON JI J. Health Econ. PD DEC PY 2008 VL 27 IS 6 BP 1567 EP 1581 DI 10.1016/j.jhealeco.2008.07.002 PG 15 WC Economics; Health Care Sciences & Services; Health Policy & Services SC Business & Economics; Health Care Sciences & Services GA 378WE UT WOS:000261354500013 PM 18707781 ER PT J AU Ned, RM Price, AE Crawford, SB Ayisi, JG van Eijk, AM Otieno, JA Nahlen, BL Steketee, RW Slutsker, L Shi, YP Lanar, DE Udhayakumar, V AF Ned, Renee M. Price, April E. Crawford, Sara B. Ayisi, John G. van Eijk, Anna Maria Otieno, Juliana A. Nahlen, Bernard L. Steketee, Richard W. Slutsker, Laurence Shi, Ya Ping Lanar, David E. Udhayakumar, Venkatachalam TI Effect of Placental Malaria and HIV Infection on the Antibody Responses to Plasmodium falciparum in Infants SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID MEROZOITE SURFACE PROTEIN-1; IMMUNODEFICIENCY-VIRUS-INFECTION; ASYMPTOMATIC PREGNANT-WOMEN; LIVER-STAGE ANTIGEN-1; WESTERN KENYA; MATERNAL HIV; IMMUNE-RESPONSES; RISK-FACTORS; HUMORAL IMMUNITY; TRANSMISSION AB Background. Placental malaria (PM) and maternal infection with human immunodeficiency virus (HIV) type 1 have been shown to affect infant morbidity and immune responses to Plasmodium falciparum. We studied the effects of PM and HIV infection on the antimalarial antibody responses and morbidity outcomes of infants throughout the first year of life. Methods. A total of 411 Kenyan infants who were born to mothers who were singly or dually infected with PM and/or HIV had their levels of immunoglobulin G antibody to 6 P. falciparum antigens/epitopes (apical membrane antigen-1, erythrocyte-binding antigen-175; liver-stage antigen-1 [LSA-1], circumsporozoite protein [CSP], merozoite surface protein-2, and rhoptry-associated protein-1 [RAP-1]) and to tetanus toxoid (TT) tested using enzyme-linked immunosorbent assay. Results. PM had little effect on the antibody responses of infants, whereas maternal HIV infection resulted in decreased levels of antibody to LSA-1, CSP, and RAP-1 epitopes at birth, compared with the absence of PM and maternal HIV infection (P < .0063). Levels of antibodies to TT were significantly reduced in infants born to mothers coinfected with HIV and PM, compared with the levels noted in infants born to HIV-negative mothers (P < .0003). In HIV-infected infants, levels of antibody to TT were reduced, but levels of antibody to malarial antigens were not. Antimalarial antibody levels were positively associated with malaria-related morbidity outcomes. Conclusion. Infant HIV infection and maternal coinfection with HIV and PM negatively influence antibody responses to TT, but not those to malarial antigens, in infants. Antimalarial antibodies rarely showed protective associations with morbidity in infants and were more often a marker for malaria exposure and risk of infection. C1 [Ned, Renee M.; Price, April E.; Steketee, Richard W.; Slutsker, Laurence; Shi, Ya Ping; Udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Malaria Branch, Chamblee, GA 30341 USA. [Crawford, Sara B.] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Coordinating Ctr Infect Dis, Chamblee, GA 30341 USA. [Crawford, Sara B.] Atlanta Res & Educ Fdn, Decatur, GA USA. [Lanar, David E.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Ayisi, John G.; van Eijk, Anna Maria] Kenya Govt Med Res Ctr, Kisumu, Kenya. [Otieno, Juliana A.] New Nyanza Prov Hosp, Kisumu, Kenya. [Nahlen, Bernard L.] WHO, CH-1211 Geneva, Switzerland. RP Udhayakumar, V (reprint author), Ctr Dis Control & Prevent, Malaria Branch, 4770 Buford Highway,Mail Stop F-12, Chamblee, GA 30341 USA. EM vxu0@cdc.gov RI Ned, Renee/D-3746-2009; Lanar, David/B-3560-2011 FU Atlanta Research and Educational Foundation; Centers for Disease Control and Prevention (CDC)/Division of HIV and AIDS Prevention [CDC IAA 98FED09325]; Emerging Infectious Diseases (EID) Postdoctoral Fellowship Program FX Financial support: Atlanta Research and Educational Foundation and Centers for Disease Control and Prevention (CDC)/Division of HIV and AIDS Prevention (grant CDC IAA 98FED09325). R.M.N. was supported by an appointment to the Emerging Infectious Diseases (EID) Postdoctoral Fellowship Program, and A. E. P. was supported by an appointment to the EID Training Fellowship Program; both programs were administered by the Association of Public Health Laboratories and funded by the CDC. NR 41 TC 11 Z9 11 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 1 PY 2008 VL 198 IS 11 BP 1609 EP 1619 DI 10.1086/593066 PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 374NY UT WOS:000261052200006 PM 18928377 ER PT J AU Fowlkes, AL Honarmand, S Glaser, C Yagi, S Schnurr, D Oberste, MS Anderson, L Pallansch, MA Khetsuriani, N AF Fowlkes, Ashley L. Honarmand, Somayeh Glaser, Carol Yagi, Shigeo Schnurr, David Oberste, M. Steven Anderson, Larry Pallansch, Mark A. Khetsuriani, Nino TI Enterovirus-Associated Encephalitis in the California Encephalitis Project, 1998-2005 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT 43rd Annual Meeting of the Infectious-Diseases-Society-of-America CY OCT 06-09, 2005 CL San Francisco, CA SP Infect Dis Soc Amer ID ACUTE CHILDHOOD ENCEPHALITIS; CENTRAL-NERVOUS-SYSTEM; UNITED-STATES; ASEPTIC-MENINGITIS; FOCAL ENCEPHALITIS; INFECTIONS; ETIOLOGIES; DIAGNOSIS; OUTBREAK; CHILDREN AB Background. Encephalitis is a relatively rare presentation of enterovirus (EV) infections. Clinical and epidemiologic characteristics of EV encephalitis (EVE) have not been well characterized. Methods. Patients with encephalitis enrolled in the California Encephalitis Project from 1998 to 2005 were tested for a range of pathogens, including EV, using a standardized diagnostic algorithm. EVE was categorized as "confirmed" (EV detected in cerebrospinal fluid [CSF] or brain tissue) or "possible" (EV found in respiratory or fecal specimens or serum EV immunoglobulin [Ig] Mdetected). We compared clinical and epidemiologic characteristics of EVE with those of other infectious encephalitis cases. Results. EVE was diagnosed in 73 (4.6%) of 1571 patients (45 confirmed cases, 28 possible cases); 11.1% of cases had other infectious causes. Patients with confirmed EVE were younger, although 27% were adults, who presented with significantly less severe symptoms. Serotypes identified in EVE cases correlated with the predominant serotype for the given year reported to the National Enterovirus Surveillance System at the Centers for Disease Control and Prevention. Two of 4 fatal EVE cases were associated with EV71. Conclusion. EVs are an important cause of encephalitis cases requiring hospitalization, in both children and adults. Our data suggest that EVE severity varies by serotype, confirm the importance of CSF/brain tissue polymerase chain reaction, and demonstrate that serum IgM findings are of little value in diagnosing EVE. C1 [Fowlkes, Ashley L.; Oberste, M. Steven; Anderson, Larry; Pallansch, Mark A.; Khetsuriani, Nino] Ctr Dis Control & Prevent, Atlanta, GA USA. [Honarmand, Somayeh; Glaser, Carol; Yagi, Shigeo; Schnurr, David] Calif Dept Publ Hlth, Richmond, CA USA. RP Fowlkes, AL (reprint author), 1600 Clifton Rd NE,Mailstop A34, Atlanta, GA 30333 USA. EM ahl4@cdc.gov FU PHS HHS [5U01 C10 00309-04] NR 33 TC 44 Z9 47 U1 0 U2 5 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 1 PY 2008 VL 198 IS 11 BP 1685 EP 1691 DI 10.1086/592988 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 374NY UT WOS:000261052200015 PM 18959496 ER PT J AU Brown, DS Finkelstein, EA Mercy, JA AF Brown, Derek S. Finkelstein, Eric A. Mercy, James A. TI Methods for Estimating Medical Expenditures Attributable to Intimate Partner Violence SO JOURNAL OF INTERPERSONAL VIOLENCE LA English DT Article DE medical expenditures; medical costs; top-down; bottom-up; econometric; intimate partner violence ID HEALTH-CARE USE; UNITED-STATES; ECONOMIC BURDEN; WOMEN; RISK; COSTS; DISORDERS; SUICIDE; ABUSE; HMO AB This article compares three methods for estimating the medical cost burden of intimate partner violence against U.S. adult women (18 years and older), 1 year postvictimization. To compute the estimates, prevalence data from the National Violence Against Women Survey are combined with cost data from the Medical Expenditure Panel Survey, the Medicare 5% sample, and published studies and with relative risk estimates from published studies. Results are compared and reasons for difference are explored, including the advantages and disadvantages of each approach. Estimates of the medical cost burden of intimate partner violence within the first 12 months after victimization range from $2.3 billion to $7.0 billion, depending on the method used. Although limited to women victimized in the last year, each method reveals that intimate partner violence imposes a substantial burden on the health care system. Among the approaches, there is no clear gold standard nor any evidence of bias. C1 [Mercy, James A.] Ctr Dis Control & Prevent, Strateg Direct, Div Violence Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA. RI Brown, Derek/J-3035-2013 OI Brown, Derek/0000-0001-9908-9882 NR 40 TC 21 Z9 21 U1 0 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0886-2605 J9 J INTERPERS VIOLENCE JI J. Interpers. Violence PD DEC PY 2008 VL 23 IS 12 BP 1747 EP 1766 DI 10.1177/0886260508314338 PG 20 WC Criminology & Penology; Family Studies; Psychology, Applied SC Criminology & Penology; Family Studies; Psychology GA 368KB UT WOS:000260618900005 PM 18314507 ER PT J AU Abidi, FE Holloway, L Moore, CA Weaver, DD Simensen, RJ Stevenson, RE Rogers, RC Schwartz, CE AF Abidi, F. E. Holloway, L. Moore, C. A. Weaver, D. D. Simensen, R. J. Stevenson, R. E. Rogers, R. C. Schwartz, C. E. TI Mutations in JARID1C are associated with X-linked mental retardation, short stature and hyperreflexia SO JOURNAL OF MEDICAL GENETICS LA English DT Article ID SPLICE-SITE; GENE; PREVALENCE; DISABILITY; PROTEINS; DISORDER AB Background: Mutations in the JARID1C (Jumonji AT-rich interactive domain 1C) gene were recently associated with X-linked mental retardation (XLMR). Mutations in this gene are reported to be one of the relatively more common causes of XLMR with a frequency of approximately 3% in males with proven or probable XLMR. The JARID1C protein functions as a histone 3 lysine 4 (H3K4) demethylase and is involved in the demethylation of H3K4me3 and H3K4me2. Methods: Mutation analysis of the JARID1C gene was conducted in the following cohorts: probands from 23 XLMR families linked to Xp11.2, 92 males with mental retardation and short stature, and 172 probands from small XLMR families with no linkage information. Results: Four novel mutations consisting of two missense mutations, p.A77T and p.V504M, and two frame shift mutations, p.E468fsX2 and p.R1481fsX9, were identified in males with mental retardation. Two of the mutations, p.V504M and p.E468fsX2, are located in the JmjC domain of the JARID1C gene where no previous mutations have been reported. Additional studies showed that the missense mutation, p. V504M, was a de novo event on the grandpaternal X chromosome of the family. Clinical findings of the nine affected males from the four different families included mental retardation (100%), short stature (55%), hyperreflexia (78%), seizures (33%) and aggressive behaviour (44%). The degree of mental retardation consisted of mild (25%), moderate (12%) and severe (63%). Conclusion: Based on the clinical observations, male patients with mental retardation, short stature and hyperreflexia should be considered candidates for mutations in the JARID1C gene. C1 [Abidi, F. E.; Holloway, L.; Simensen, R. J.; Stevenson, R. E.; Rogers, R. C.; Schwartz, C. E.] Greenwood Genet Ctr, JC Self Res Inst, Greenwood, SC 29646 USA. [Moore, C. A.] Ctr Dis Control & Prevent, Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Weaver, D. D.] Indiana Univ, Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA. RP Abidi, FE (reprint author), Greenwood Genet Ctr, JC Self Res Inst Human Genet, 113 Gregor Mendel Circle, Greenwood, SC 29646 USA. EM fatimaabidi@ggc.org FU NICHD [HD26202]; South Carolina Department of Disabilities and Special Needs (SCDDSN) FX This work was supported, in part, by grants from NICHD (HD26202) to CES and the South Carolina Department of Disabilities and Special Needs (SCDDSN). NR 27 TC 39 Z9 40 U1 0 U2 0 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0022-2593 J9 J MED GENET JI J. Med. Genet. PD DEC PY 2008 VL 45 IS 12 BP 787 EP 793 DI 10.1136/jmg.2008.058990 PG 7 WC Genetics & Heredity SC Genetics & Heredity GA 378AN UT WOS:000261293600004 PM 18697827 ER PT J AU Harley, KG Marks, AR Bradman, A Barr, DB Eskenazi, B AF Harley, Kim G. Marks, Amy R. Bradman, Asa Barr, Dana B. Eskenazi, Brenda TI DDT Exposure, Work in Agriculture, and Time to Pregnancy Among Farmworkers in California SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID FEMALE GREENHOUSE WORKERS; PESTICIDE EXPOSURE; SERUM DDT; MENSTRUAL-CYCLE; LATINA WOMEN; INFERTILITY; FERTILITY; ESTROGEN; P,P'-DDE; QUALITY AB Objective: This study examined whether exposure to pesticides, including dichlorodiphenyltrichloroethane (DDT), was associated with longer time to pregnancy (TTP). Methods: Pregnant women (N = 402) living in a migrant farmworker community were asked how many months the), took to conceive. Women reported their and their partners' occupational and home pesticide exposure preceding conception. In a subset (N = 289), levels of DDT and dichlorodiphenyldichloroethylene (DDE), were measured in maternal serum. Results: No associations were seen with 13, p'-DDT, o, p'-DDT, or p, p'-DDE. Maternal occupational pesticide exposure (fecundability odds ratios [fOR] = 0.8, 95% CI: 0.6 to 1.0), home pesticide use (fOR = 0.6, 95% and residence within 200 ft of an agricultural field (fOR = 0.7, 95% CI: 0.4 to 0.9), CI: 0.5 to 1.0) were associated with reduced fecundability (ie, longer TTP). Conclusions: Longer TTP was seen among women, but not men, reporting exposure to agricultural and home pesticides. (J Occup Environ Med. 2008;50:1335-1342) C1 [Harley, Kim G.; Marks, Amy R.; Bradman, Asa; Eskenazi, Brenda] Univ Calif Berkeley, Sch Publ Hlth, Ctr Childrens Environm Hlth Res, Berkeley, CA 94704 USA. [Barr, Dana B.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Harley, KG (reprint author), Univ Calif Berkeley, Sch Publ Hlth, Ctr Childrens Environm Hlth Res, 2150 Shattuck Ave,Suite 600, Berkeley, CA 94704 USA. EM kharley@berkeley.edu RI Barr, Dana/E-6369-2011; Barr, Dana/E-2276-2013; OI Marks, Amy/0000-0002-3047-5379 FU U.S. EPA [RD 93171001, RD 83171001]; NIEHS [PO1 ES009605]; NIOSH [RO1 OH007400] FX This work was supported by grants from the U.S. EPA (RD 83171001), NIEHS (PO1 ES009605), and NIOSH (RO1 OH007400). NR 44 TC 18 Z9 19 U1 1 U2 13 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD DEC PY 2008 VL 50 IS 12 BP 1335 EP 1342 DI 10.1097/JOM.0b013e31818f684d PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 383XT UT WOS:000261708400003 PM 19092487 ER PT J AU Schuler, CR Kitt, MM Henneberger, PK Deubner, DC Kreiss, K AF Schuler, Christine R. Kitt, Margaret M. Henneberger, Paul K. Deubner, David C. Kreiss, Kathleen TI Cumulative Sensitization and Disease in a Beryllium Oxide Ceramics Worker Cohort SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID LYMPHOCYTE-PROLIFERATION TEST; MEDICAL SURVEILLANCE; FACILITY; PLANT; RISK; EXPOSURE; ALLOY AB Objective: We followed a cohort of 136 beryllium oxide ceramics workers from 1992 to 2003, including those who left employment, for beryllium sensitization and chronic beryllium disease (CBD), Methods: We invited the cohort's participation in current worker surveys in 1992, 1998, 2000, and 2002-2003, and in former worker surveys in 2000-2001 and 2003. We calculated 11-year cumulative incidences (after 1992 initial survey) of sensitization and CBD, both crude and corrected for interval censoring; and period prevalences (including 1992 findings), crude and corrected. Results: In 1992, point prevalences were 6 sensitized and 4% CBD. We obtained follow-up on 83% of 128 not sensitized in 1992. Crude cumulative incidences for sensitization and CBD were 13% and 9%, respectively; corrected were 15% and 11%. Crude period prevalences for sensitization and CBD were 16% and 11%, respectively; corrected were 20% and 14%. Corrected period prevalences for pre-1992 machining work were 30% and 20%. Conclusions: With repeated testing over 11 years, total sensitization and CBD in this cohort were triple initial 1992 survey results. (J Occup Environ Med. 2008;50:1343-1350) C1 [Schuler, Christine R.; Kitt, Margaret M.; Henneberger, Paul K.; Kreiss, Kathleen] NIOSH, Div Resp Dis Studies, Field Studies Branch, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. [Deubner, David C.] Brush Wellman Inc, Elmore, OH USA. RP Schuler, CR (reprint author), NIOSH, Div Resp Dis Studies, Field Studies Branch, Ctr Dis Control & Prevent, 1095 Willowdale Rd,MS H2800, Morgantown, WV 26505 USA. EM christine.schuler@cdc.hhs.gov NR 27 TC 11 Z9 11 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD DEC PY 2008 VL 50 IS 12 BP 1343 EP 1350 DI 10.1097/JOM.0b013e31818def24 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 383XT UT WOS:000261708400004 PM 19092488 ER PT J AU Alterman, T Grosch, J Chen, X Chrislip, D Petersen, M Krieg, E Chung, H Muntaner, C AF Alterman, Toni Grosch, James Chen, Xiao Chrislip, David Petersen, Martin Krieg, Edward, Jr. Chung, Haejoo Muntaner, Caries TI Examining Associations Between Job Characteristics and Health: Linking Data From the Occupational Information Network (O*NET) to Two US National Health Surveys SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID CORONARY-HEART-DISEASE; PSYCHOSOCIAL WORK-ENVIRONMENT; UNITED-STATES; CARDIOVASCULAR-DISEASE; DEMAND-CONTROL; WHITEHALL-II; RISK-FACTORS; FOLLOW-UP; STRAIN; DIMENSIONS AB Objective: To determine whether the Occupational Information Network (O*NET) database can be used to identify job dimensions to serve as proxy measures for psychosocial factors and select environmental factors, and to determine whether the the factors could be linked to national health surveys to examine associations with health risk behaviors and outcomes. Methods: job characteristics were obtained from O*NET 98. Health outcomes were obtained from two national surveys. Data were linked using Bureau of Census codes. Multiple logistic regression was used to examine associations between O*NET factors and cardiovascular disease, depression, and health risk factors. Results: Seven of nine work organization or psychosocial factors were significantly associated with health risk behaviors In both the National Health and Nutrition Examination Survey III and National Health Interview Survey. Conclusions: This study demonstrates a method for linking independently obtained. health and job characteristic data based on occupational code. (J Occup Environ Med. 2008;50:1401-1413) C1 [Alterman, Toni; Chen, Xiao; Petersen, Martin] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH 45213 USA. [Grosch, James; Chrislip, David; Krieg, Edward, Jr.] NIOSH, Div Appl Res & Technol, Cincinnati, OH 45213 USA. [Chung, Haejoo; Muntaner, Caries] Univ Toronto, Ctr Addict & Mental Hlth, Toronto, ON, Canada. RP Alterman, T (reprint author), NIOSH, Div Surveillance Hazard Evaluat & Field Studies, MS-R17,5555 Ridge Rd, Cincinnati, OH 45213 USA. EM talterman@cdc.gov RI Muntaner, C/A-5043-2010; OI Alterman, Toni/0000-0003-1512-4367 FU Centers for Disease Control and Prevention; National Institute for Occupational Safety and Health FX Funding for this study was provided by the Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health. NR 83 TC 19 Z9 19 U1 0 U2 16 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD DEC PY 2008 VL 50 IS 12 BP 1401 EP 1413 DI 10.1097/JOM.0b013e318188e882 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 383XT UT WOS:000261708400012 PM 19092496 ER PT J AU Payne, DC Parashar, UD AF Payne, Daniel C. Parashar, Umesh D. TI Epidemiological Shifts in Severe Acute Gastroenteritis in US Children: Will Rotavirus Vaccination Change the Picture? SO JOURNAL OF PEDIATRICS LA English DT Editorial Material ID UNITED-STATES; HOSPITALIZATIONS; EFFICACY; DIARRHEA; DISEASE; SAFETY C1 [Payne, Daniel C.; Parashar, Umesh D.] Ctr Dis Control & Prevent, Epidemiol Branch, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Payne, DC (reprint author), Ctr Dis Control & Prevent, Epidemiol Branch, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,Mailstop A-34, Atlanta, GA 30333 USA. EM DVP6@CDC.GOV NR 11 TC 3 Z9 3 U1 0 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 J9 J PEDIATR-US JI J. Pediatr. PD DEC PY 2008 VL 153 IS 6 BP 737 EP 738 DI 10.1016/j.jpeds.2008.08.012 PG 2 WC Pediatrics SC Pediatrics GA 383FK UT WOS:000261659300004 PM 19014813 ER PT J AU Pont, SJ Carpenter, LR Griffin, MR Jones, TF Schaffner, W Dudley, JA Arbogast, PG Cooper, WO AF Pont, Stephen J. Carpenter, L. Rand Griffin, Marie R. Jones, Timothy F. Schaffner, William Dudley, Judith A. Arbogast, Patrick G. Cooper, William O. TI Trends in Healthcare Usage Attributable to Diarrhea, 1995-2004 SO JOURNAL OF PEDIATRICS LA English DT Article ID UNITED-STATES; RISK-FACTORS; ROTAVIRUS DIARRHEA; YOUNG-CHILDREN; DISEASE BURDEN; HOSPITALIZATIONS; POPULATION; MORBIDITY; GASTROENTERITIS; EPIDEMIOLOGY AB Objective To determine current diarrhea-associated healthcare usage rates and associated sociodemographic factors. These data can be used to determine the impact of the rotavirus vaccine. Study design Using discharge diagnosis codes, we determined diarrhea-associated visit rates for children aged 0 to 18 years enrolled in Tennessee Medicaid, 1995-2004. Poisson regression compared data across time and within strata. The winter residual excess method estimated the rotavirus burden. Results Analyzing approximately 500 000 person-years annually, outpatient and hospitalization rates remained stable from 1995 to 2004; emergency department (ED) rates approximately doubled, incidence rate ratio (IRR): 1.92 (1.81-2.04). White children used healthcare greater rates than black children: outpatient IRR 1.90: (1.85-1.95), ED IRR: 1.69 (1.64-1.74), and inpatient IRR: 1.82 (1.73-1.92); and rural children greater than urban: outpatient IRR 1.66 (1.62-1.70). ED IRR 1.14 (1.11-1.17), inpatient IRR 1.88 (1.80-1.97). Children aged 0 to 35 months experienced 1627 outpatient and 792 E D visits, and 148 hospitalizations per 10 000 child-years; rotavirus may have affected up to 40% of these hospitalizations. Conclusions Diarrhea-associated ED visit rates nearly doubled from 1995 to 2004. Future studies could explore factors resulting in increased healthcare usage by white children and those living in rural areas and document the rotavirus vaccine's impact after its release. (J Pediatr 2008;153:777-82) C1 [Pont, Stephen J.; Cooper, William O.] Vanderbilt Univ, Dept Pediat, Nashville, TN 37235 USA. [Griffin, Marie R.; Schaffner, William; Dudley, Judith A.; Arbogast, Patrick G.] Vanderbilt Univ, Dept Prevent Med, Nashville, TN USA. [Arbogast, Patrick G.] Vanderbilt Univ, Dept Biostat, Nashville, TN USA. [Carpenter, L. Rand; Jones, Timothy F.] Vanderbilt Univ, Tennessee Dept Hlth, Nashville, TN USA. [Carpenter, L. Rand] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. RP Pont, SJ (reprint author), Vanderbilt Univ, Dept Pediat, Nashville, TN 37235 USA. FU National Institutes of Health National Research Service Award [5T32 HS013833-03]; Tennessee Department of Health FX This study was supported by a National Institutes of Health National Research Service Award Grant, 5T32 HS013833-03 and by the Tennessee Department of Health, through the use of the TennCare data files. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. The authors declare no conflicts of interest relating to this work NR 30 TC 12 Z9 13 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 J9 J PEDIATR JI J. Pediatr. PD DEC PY 2008 VL 153 IS 6 BP 777 EP 782 DI 10.1016/j.jpeds.2008.06.037 PG 6 WC Pediatrics SC Pediatrics GA 383FK UT WOS:000261659300014 PM 18692199 ER PT J AU Reller, MD Strickland, MJ Riehle-Colarusso, T Mahle, WT Correa, A AF Reller, Mark D. Strickland, Matthew J. Riehle-Colarusso, Tiffany Mahle, Wiluam T. Correa, Adolfo TI Prevalence of Congenital Heart Defects in Metropolitan Atlanta, 1998-2005 SO JOURNAL OF PEDIATRICS LA English DT Article ID CARDIOVASCULAR MALFORMATIONS; BIRTH-DEFECTS; UNITED-STATES; DISEASE; INFANT; RISK AB Objective To determine an accurate estimate of the prevalence of congenital heart defects (CHD) using current standard diagnostic modalities. Study design Nile obtained data on infants with CHD delivered during 1998 to 2005 identified by the Metropolitan Atlanta, Congenital Defects Program, an active, population-based, birth defects surveillance system. Physiologic shunts in infancy and shunts associated with prematurity were excluded. Selected infant and maternal characteristics of the cases were compared with those of the overall birth cohort. Results From 1998 to 2005 there were 398 140 births, of which 3240 infants had CHD, for an overall prevalence of 81.4/10 000 births. The most common CHD were muscular ventricular septal defect, perimembranous ventricular septal defect, and secundum atrial septal defect, with prevalence of 27.5, 10.6, and 10.3/10 000 births, respectively. The prevalence of tetralogy of Fallot, the most common cyanotic CHD, was twice that of transposition of the great arteries (4.7 vs 2.3/10 000 births). Many common CHD were associated with older maternal age and multiple-gestation pregnancy; several were found to vary by sex. Conclusions This study, using a standardized cardiac nomenclature and classification, provides current prevalence estimates of the various CHD subtypes. These estimates can be used to assess variations in prevalence across populations, time, or space. (J Pediatr 2008;153:807-13) C1 [Reller, Mark D.] Oregon Hlth & Sci Univ, Div Pediat Cardiol, CDRC P, Portland, OR 97239 USA. [Strickland, Matthew J.; Riehle-Colarusso, Tiffany; Correa, Adolfo] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Strickland, Matthew J.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Mahle, Wiluam T.] Emory Univ, Childrens Healthcare Atlanta, Atlanta, GA 30322 USA. RP Reller, MD (reprint author), Oregon Hlth & Sci Univ, Div Pediat Cardiol, CDRC P, 707 SW Gaines Rd, Portland, OR 97239 USA. EM rellerm@ohsu.edu FU National Institute of Environmental Health Sciences (NIEHS) [R01-ES012967-01A1] FX Supported by National Institute of Environmental Health Sciences (NIEHS) grant R01-ES012967-01A1. NR 22 TC 248 Z9 259 U1 0 U2 10 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 J9 J PEDIATR JI J. Pediatr. PD DEC PY 2008 VL 153 IS 6 BP 807 EP 813 DI 10.1016/j.jpeds.2008.05.059 PG 7 WC Pediatrics SC Pediatrics GA 383FK UT WOS:000261659300020 PM 18657826 ER PT J AU Ouyang, LJ Fang, XM Mercy, J Perou, R Grosse, SD AF Ouyang, Lijing Fang, Xiangming Mercy, James Perou, Ruth Grosse, Scott D. TI Attention-Deficit/Hyperactivity Disorder Symptoms and Child Maltreatment: A Population-Based Study SO JOURNAL OF PEDIATRICS LA English DT Article ID CORPORAL PUNISHMENT; VIOLENCE PREVENTION; SEXUAL-ABUSE; RISK-FACTORS; HYPERACTIVITY; ASSOCIATION; EXPERIENCES; FAMILIES; NEGLECT; DEFICIT AB Objective To examine whether symptoms of attention-deficit/hyperactivity disorder (ADHD) during childhood are associated with child maltreatment. Study design The study sample consisted of 14 322 participants in the National Longitudinal Study of Adolescent Health. We used logistic regression and propensity score matching to examine the relationship, adjusting for demographic, socioeconomic, and familial risk factors for child maltreatment. Results Inattentive type, by criteria of Diagnostic and Statistic, Manual of Mental Disorders Fourth Edition, was significantly associated with the likelihood of supervision neglect (odds ratio [OR]: 1.6; 95% confidence interval [CI]: 1.2-2.2), physical neglect (OR: 2.1; 95% CI: 1.4-3.1), physical abuse (OR: 1.6; 95% CI: 1.1-2.3), and contact sexual abuse (OR: 2.6; 95% CI: 1.5-4.5). To a lesser extent, hyperactive type was associated with the likelihood of supervision neglect (OR: 1.5; 95% CI: 1.1-2.0) and physical abuse (OR: 1.3; 95% CI: 1.0-1.6). The association between hyperactive type and physical neglect or contact sexual abuse was not significant. The results from the propensity score matching were similar. Conclusions Childhood ADHD symptoms were associated with self-reported child maltreatment. Health care providers should be alert to the potential for child maltreatment among children with ADHD symptoms, especially those with inattentive symptoms. (J Pediatr 2008;153:851-6) C1 [Ouyang, Lijing; Perou, Ruth; Grosse, Scott D.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Fang, Xiangming; Mercy, James] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA. RP Ouyang, LJ (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd NE,Mail Stop E-88, Atlanta, GA 30333 USA. EM eop9@cdc.gov RI Fang, Xiangming/O-1653-2014 OI Fang, Xiangming/0000-0001-9922-8977 NR 27 TC 60 Z9 63 U1 2 U2 11 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 J9 J PEDIATR JI J. Pediatr. PD DEC PY 2008 VL 153 IS 6 BP 851 EP 856 DI 10.1016/j.jpeds.2008.06.002 PG 6 WC Pediatrics SC Pediatrics GA 383FK UT WOS:000261659300030 PM 18619612 ER PT J AU Dennison, DA Yin, ZN Kibbe, D Burns, S Trowbridge, F AF Dennison, David A. Yin, Zenong Kibbe, Debra Burns, Susan Trowbridge, Frederick TI Training health care professionals to manage overweight adolescents: Experience in rural georgia communities SO JOURNAL OF RURAL HEALTH LA English DT Article ID PHYSICAL-ACTIVITY; PEDIATRIC OVERWEIGHT; IMPROVE MANAGEMENT; UNITED-STATES; CHILDREN; OBESITY; PREVALENCE; CHILDHOOD; NONOBESE; BURDEN AB Context: The obesity epidemic threatens the present and future health of adolescents in the United States. Yet, health care providers lack specific training for pediatric obesity assessment and management. Purpose: This study examined the adherence of rural Georgia primary care practitioners to an overweight adolescent management protocol. The study also documented the prevalence of obesity-associated physiological and behavioral risk factors among overweight adolescent patients. Methods: Ten rural clinics (58 providers) were recruited and received a 90-minute adolescent overweight assessment and management training session. Select biochemical, dietary, physical activity, and physical inactivity behaviors were assessed in overweight adolescent patients. Medical charts were abstracted to assess practitioner compliance with an overweight assessment protocol and patient adherence to a 16-week follow-up visit. Findings: Providers were receptive to training and complied with the recommended protocol. Eighty-five overweight adolescents were assessed, but only 49 (57%) completed the scheduled 16-week follow-up visit. Physical, biochemical, and behavioral assessments revealed that 13%-27% of the participants had abnormal levels of lipids, fasting glucose, and glucose/insulin ratio, and 80.5% had waist circumferences above the 90th percentile. Conclusions: Practitioners complied with the assessment and follow-up protocol, leading to the discovery of previously unrecognized risk factors in many overweight adolescent patients. Lack of patient adherence to follow-up was the greatest limiting factor for obesity management. Further efforts are needed to implement and evaluate training to improve the management of adolescent overweight, especially in rural communities. C1 [Dennison, David A.] Ctr Dis Control & Prevent, Div Nutr Phys Activ & Obes, Atlanta, GA 30341 USA. [Dennison, David A.; Kibbe, Debra] ILSI Res Fdn, Washington, DC USA. [Yin, Zenong] Univ Texas San Antonio, Coll Educ & Human Dev, Dept Hlth & Kinesiol, San Antonio, TX USA. [Burns, Susan] Amer Acad Pediat, Atlanta, GA USA. [Trowbridge, Frederick] Trowbridge & Assoc Inc, Decatur, GA USA. RP Dennison, DA (reprint author), Ctr Dis Control & Prevent, Div Nutr Phys Activ & Obes, 4770 Buford Hwy,NE,MS K-24, Atlanta, GA 30341 USA. EM ddennison@cdc.gov NR 30 TC 7 Z9 7 U1 0 U2 8 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0890-765X J9 J RURAL HEALTH JI J. Rural Health PD WIN PY 2008 VL 24 IS 1 BP 55 EP 59 DI 10.1111/j.1748-0361.2008.00137.x PG 5 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA 258WF UT WOS:000252899800007 PM 18257871 ER PT J AU Wang, LY Gutin, B Barbeau, P Moore, JB Hanes, J Johnson, MH Cavnar, M Thornburg, J Yin, Z AF Wang, Li Yan Gutin, Bernard Barbeau, Paule Moore, Justin B. Hanes, John, Jr. Johnson, Maribeth H. Cavnar, Marlo Thornburg, Janet Yin, Zenong TI Cost-Effectiveness of a School-Based Obesity Prevention Program SO JOURNAL OF SCHOOL HEALTH LA English DT Article DE cost-effectiveness; after-school program; physical activity ID GEORGIA FITKID PROJECT; PHYSICAL-ACTIVITY; MEDICAL-COLLEGE; UNITED-STATES; DIABETES-MELLITUS; CHILDREN; ADOLESCENTS; HEALTH; OVERWEIGHT; INTERVENTIONS AB A school-based obesity prevention study (Medical College of Georgia FitKid Project) started in the fall of 2003 in 18 elementary schools. Half of the schools were randomized to an after-school program that included moderate-to-vigorous physical activity, healthy snacks, homework assistance, and academic enrichment. All third graders were invited to enroll. The objective of this study was to assess the cost-effectiveness (CE) of the first-year intervention. Standard CE analysis methods and a societal perspective were used. Program delivery costs incurred during the first-year intervention and the usual after-school care costs that would occur in the absence of the intervention were estimated (in 2003 dollars). Net intervention costs were calculated by subtracting the usual after-school care costs from the intervention costs. The effectiveness of the intervention was measured as percent body fat (%BF) reduction compared with a control condition. The CE was assessed as the net intervention cost divided by the effectiveness of the intervention. The intervention costs totaled $174,070, $558/student, or $956/student who attended >= 40% of the intervention sessions. The usual after-school care costs were estimated at $639/student. Students who attended >= 40% of the intervention reduced %BF by 0.76% (95% confidence interval: -1.42 to -0.09) at an additional cost of $317/student. Subjects who attended >= 40% of the intervention achieved a significant reduction in %BF at a relatively low cost. School-based obesity prevention programs of this type are likely to be a cost-effective use of public funds and warrant careful consideration by policy makers and program planners. C1 [Wang, Li Yan] Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Gutin, Bernard] Univ N Carolina Chapel Hill, Dept Nutr, Raleigh, NC 27617 USA. [Barbeau, Paule; Cavnar, Marlo] Med Coll Georgia, Georgia Prevent Inst, Dept Pediat, Augusta, GA 30912 USA. [Moore, Justin B.] E Carolina Univ, Brody Sch Med, Dept Publ Hlth, Greenville, NC 27834 USA. [Hanes, John, Jr.] Regent Univ, Sch Educ, Virginia Beach, VA 23464 USA. [Johnson, Maribeth H.] Med Coll Georgia, Dept Biostat, Augusta, GA 30912 USA. [Thornburg, Janet] Family Y, Metro Child Care Serv, N Augusta, SC 29841 USA. [Yin, Zenong] Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX 78023 USA. RP Wang, LY (reprint author), Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy,MS K-33, Chamblee, GA 30341 USA. EM lgw0@cdc.gov; bernardgutin@yahoo.com; pbarbeau@mail.mcg.edu; moorej@ecu.edu; jhanes@regent.edu; majohnso@mcg.edu; MVERNON@mail.mcg.edu; jthornburg@thefamilyy.org; Zenong.Yin@utsa.edu RI Moore, Justin/B-9357-2012 OI Moore, Justin/0000-0003-4059-0538 FU National Institute of Health [DK63391] FX The implementation and effectiveness evaluation of the MCG FitKid Project were supported by a grant from the National Institute of Health (DK63391). NR 31 TC 36 Z9 37 U1 3 U2 13 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-4391 J9 J SCHOOL HEALTH JI J. Sch. Health PD DEC PY 2008 VL 78 IS 12 BP 619 EP 624 DI 10.1111/j.1746-1561.2008.00357.x PG 6 WC Education & Educational Research; Education, Scientific Disciplines; Health Care Sciences & Services; Public, Environmental & Occupational Health SC Education & Educational Research; Health Care Sciences & Services; Public, Environmental & Occupational Health GA 374TG UT WOS:000261066000001 PM 19000237 ER PT J AU Zapata, LB Hillis, SD Marchbanks, PA Curtis, KM Lowry, R AF Zapata, Lauren B. Hillis, Susan D. Marchbanks, Polly A. Curtis, Kathryn M. Lowry, Richard TI Methamphetamine Use Is Independently Associated With Recent Risky Sexual Behaviors and Adolescent Pregnancy SO JOURNAL OF SCHOOL HEALTH LA English DT Article DE child and adolescent health; drugs; human sexuality; reproductive health; public health ID HIGH-SCHOOL-STUDENTS; DRUG-USE; SUBSTANCE USE; BISEXUAL MEN; GAY; INTERCOURSE; AMERICAN; YOUTH AB Lifetime methamphetamine use among adolescents is estimated to be between 5% and 10%. Youth substance use in general is known to be associated with risky sexual behaviors, but the effect of methamphetamine use on recent risky sexual behaviors and adolescent pregnancy has received little attention. The purpose of this analysis was to evaluate the association between lifetime methamphetamine use and recent (past 3 months) risky sexual behaviors and lifetime adolescent pregnancy, adjusting for other substance use. We analyzed data from the 2003 National Youth Risk Behavior Survey, a school-based paper-and-pencil survey that assesses risky health behaviors among a nationally representative sample of 9th- to 12th-grade students. Multivariable logistic regression was used to calculate adjusted odds ratios (AORs) to examine the association between methamphetamine use and being recently sexually active, having 2 or more recent sex partners, and ever being pregnant or getting someone pregnant. Lifetime methamphetamine use was reported by 7.6% of students. After adjustment for demographic covariates and lifetime use of cigarettes, alcohol, marijuana, and other illicit drugs, lifetime methamphetamine use was associated with recent sexual intercourse (AOR = 1.8, 95% confidence interval [CI] = 1.5-2.3), having 2 or more recent sex partners (AOR = 3.0, 95% CI = 2.2-4.2), and ever being pregnant or getting someone pregnant (AOR = 2.9, 95% CI = 2.1-3.9). Adolescent methamphetamine use is common and is associated with recent risky sexual behaviors and adolescent pregnancy. Prevention strategies for high school students should integrate education on substance abuse, pregnancy, sexually transmitted infections, and human immunodeficiency virus. C1 [Zapata, Lauren B.; Hillis, Susan D.; Marchbanks, Polly A.; Curtis, Kathryn M.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, Womens Hlth & Fertil Branch, Atlanta, GA 30341 USA. [Lowry, Richard] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Adolescent & Sch Hlth, Surveillance & Evaluat Res Branch, Atlanta, GA 30341 USA. RP Zapata, LB (reprint author), Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, Womens Hlth & Fertil Branch, 4770 Buford Hwy,NE Mailstop K34, Atlanta, GA 30341 USA. EM dvq8@cdc.gov; shillis@cdc.gov; pam2@cdc.gov; kmc6@cdc.gov; rxl1@cdc.gov NR 40 TC 18 Z9 19 U1 2 U2 4 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-4391 J9 J SCHOOL HEALTH JI J. Sch. Health PD DEC PY 2008 VL 78 IS 12 BP 641 EP 648 DI 10.1111/j.1746-1561.2008.00360.x PG 8 WC Education & Educational Research; Education, Scientific Disciplines; Health Care Sciences & Services; Public, Environmental & Occupational Health SC Education & Educational Research; Health Care Sciences & Services; Public, Environmental & Occupational Health GA 374TG UT WOS:000261066000004 PM 19000240 ER PT J AU Chen, PL Huang, WG Chuang, YL Warren, CW Jones, NR Asma, S AF Chen, Ping-Ling Huang, Weigang Chuang, Yi-Li Warren, Charles W. Jones, Nathan R. Asma, Samira TI Prevalence of tobacco use among junior high and senior high school students in Taiwan SO JOURNAL OF SCHOOL HEALTH LA English DT Article DE tobacco; schools; surveillance; Taiwan ID SMOKING AB Tobacco use is a major preventable cause of death in the world. This article describes and compares tobacco use prevalence for students attending junior high schools and senior high schools in Taiwan. This report uses data from the Global Youth Tobacco Survey (GYTS) completed among 4689 junior high school students and 4426 senior high school students in Taiwan in 2004-2005. The GYTS uses a 2-stage sampling design to produce nationally representative data for junior and senior high students in general and vocational schools. Higher smoking prevalence was observed among senior high (10.1% general schools and 15.9% vocational schools) than junior high (5.5%) school students. Smoking prevalence of girls in junior high (3.2%) and senior high schools (4.6% general and 11.1% vocational) was almost as high or higher than adult females' (4.3%) smoking rates. The pattern of smoking intensity across school years and type of school shows that the percentage of smokers who were experimenters (47.1%) was higher in junior high school and the percentage of smokers who were regular/established smokers (over 50%) was higher in senior high school. Smoking prevalence described in this report shows that there are challenges facing the tobacco prevention and control program in Taiwan. The findings suggest that schools should increase their smoking initiation prevention efforts and make available cessation programs and counseling to help students quit smoking. If effective youth tobacco control programs are not developed and implemented in Taiwan, future morbidity and mortality attributed to tobacco will surely increase, especially among women. C1 [Chen, Ping-Ling] Taipei Med Univ, Taipei 110, Taiwan. [Huang, Weigang] Taiwan Dept Hlth, Bur Hlth Promot, Taichung 408, Taiwan. [Jones, Nathan R.] Univ Wisconsin, Paul P Carbone Comprehens Canc Ctr, Survey Res Shared Serv, Madison, WI USA. [Asma, Samira] Ctr Dis Control & Prevent, Global Tobacco Control Program, Off Smoking & Hlth, Atlanta, GA 30341 USA. [Chuang, Yi-Li] Dept Hlth, Bur Hlth Promot, Populat & Hlth Res Ctr, Taichung 408, Taiwan. RP Warren, CW (reprint author), 4770 Buford Hwy NE,MS K50, Atlanta, GA 30341 USA. EM plchen@tmu.edu.tw; yilic@bhp.doh.gov.tw; wcw1@cdc.gov; naj5@cdc.gov; sea5@cdc.gov NR 17 TC 11 Z9 11 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-4391 J9 J SCHOOL HEALTH JI J. Sch. Health PD DEC PY 2008 VL 78 IS 12 BP 649 EP 654 DI 10.1111/j.1746-1561.2008.00361.x PG 6 WC Education & Educational Research; Education, Scientific Disciplines; Health Care Sciences & Services; Public, Environmental & Occupational Health SC Education & Educational Research; Health Care Sciences & Services; Public, Environmental & Occupational Health GA 374TG UT WOS:000261066000005 PM 19000241 ER PT J AU Peterson, AT Robbins, A Restifo, R Howell, J Nasci, R AF Peterson, A. Townsend Robbins, Amber Restifo, Robert Howell, James Nasci, Roger TI Predictable ecology and geography of West Nile virus transmission in the central United States SO JOURNAL OF VECTOR ECOLOGY LA English DT Article DE West Nile virus; ecological niche modeling; prediction; forecasting ID SEROLOGIC EVIDENCE; GENETIC-ALGORITHM; CHAGAS-DISEASE; NICHE MODELS; DISTRIBUTIONS; VECTOR; CLIMATE; MEXICO; BIRDS; RISK AB West Nile virus (WNV) arrived in North America and spread rapidly through the western hemisphere. We present a series of tests to determine whether ecological factors are consistently associated with WNV transmission to humans. We analyzed human WNV cases in the states of Illinois, Indiana, and Ohio in 2002 and 2003, building ecological niche models to associate WNV case occurrences with ecological and environmental parameters. In essentially all tests, both within states, among states, between years, and across the region, we found high predictivity of WNV case distributions, suggesting that one or more elements in the WNV transmission cycle has a strong ecological determination. Areas in the geographic region included in this study predicted as suitable for WNV transmission tended to have lower values of the vegetation indices in the summer months, pointing to consistent ecological differences between suitable and unsuitable areas. Journal of Vector Ecology 33 (2): 342-352. 2008. C1 [Peterson, A. Townsend; Robbins, Amber] Univ Kansas, Nat Hist Museum, Lawrence, KS 66045 USA. [Peterson, A. Townsend; Robbins, Amber] Univ Kansas, Biodivers Res Ctr, Lawrence, KS 66045 USA. [Restifo, Robert] Ohio Dept Hlth, Vector Borne Dis Unit, Columbus, OH 43229 USA. [Howell, James] Indiana State Dept Hlth, Epidemiol Resource Ctr, Indianapolis, IN 46204 USA. [Nasci, Roger] Ctr Dis Control & Prevent, Ft Collins, CO 80522 USA. RP Peterson, AT (reprint author), Univ Kansas, Nat Hist Museum, Lawrence, KS 66045 USA. RI Peterson, A. Townsend/I-5697-2013 OI Peterson, A. Townsend/0000-0003-0243-2379 FU U.S. Department of Defense FX Thanks to Monica Papes for her always-expert assistance with GIS and remotely-sensed imagery and to George K. Rafeedie and Harold Duckler of the Illinois Department of Health for their generous provision of data. This work was funded in part by a contract from the U.S. Department of Defense. NR 51 TC 10 Z9 10 U1 2 U2 15 PU SOC VECTOR ECOLOGY PI CORONA PA 1966 COMPTON AVE, CORONA, CA 92881 USA SN 1081-1710 J9 J VECTOR ECOL JI J. Vector Ecol. PD DEC PY 2008 VL 33 IS 2 BP 342 EP 352 PG 11 WC Entomology SC Entomology GA 395LB UT WOS:000262524500017 PM 19263855 ER PT J AU Morway, C Kosoy, M Eisen, R Montenieri, J Sheff, K Reynolds, PJ Powers, N AF Morway, Christina Kosoy, Michael Eisen, Rebecca Montenieri, John Sheff, Kelly Reynolds, Pamela J. Powers, Nelson TI A longitudinal study of Bartonella infection in populations of woodrats and their fleas SO JOURNAL OF VECTOR ECOLOGY LA English DT Article DE Bartonella; flea; woodrat; Neotoma micropus; Neotoma albigula ID RODENT-ASSOCIATED BARTONELLA; VINSONII SUBSP ARUPENSIS; GROUND-SQUIRRELS; BLOOD CULTURE; UNITED-STATES; PRAIRIE DOGS; STRAINS; DIVERSITY; TRANSMISSION; PREVALENCE AB Rodent-borne bartonellae have been identified as human pathogens. Little is known about Bartonella infections in woodrat hosts and their fleas and how woodrat-flea associations may affect the dynamics of Bartonella infections. We collected blood samples and fleas from two species of woodrats (Neotoma micropus and N. albigula) from Santa Fe County, NM, from 2002-2005. The most predominant flea species were Orchopeas sexdentatus and O. neotomae. Bartonella prevalence in woodrats was 64% overall, with a lower prevalence occurring in the pre-reproductive period compared to the early and late reproductive periods. A negative correlation between Bartonella prevalence in N. micropus and weight of N. micropus was observed. Flea load in Neotoma species was highest in the early reproductive period compared to the pre- and late reproductive periods and was higher in N. micropus compared to N. albigula. Bartonella prevalence in fleas was highest in the early reproductive period and lowest in the late reproductive period, and it was higher in fleas collected from N. micropus than in fleas collected from N. albigula. Abundance of O. sexdentatus was significantly higher in N. micropus compared to N. albigula, and abundance of O. sexdentatus and O. neotomae was highest in the early reproductive period. No direct correlations were found either between Bartonella prevalence in woodrats and in fleas or between Bartonella prevalence in woodrats and flea loads. Out of 25 partially characterized Bartonella isolates from Neotoma woodrats, 24 belonged to one genogroup based on sequencing of the gltA gene. Journal of Vector Ecology 33 (1): 353-364. 2008. C1 [Morway, Christina; Kosoy, Michael; Eisen, Rebecca; Montenieri, John; Sheff, Kelly] Ctr Dis Control & Prevent, Ft Collins, CO 80521 USA. [Reynolds, Pamela J.; Powers, Nelson] New Mexico Dept Hlth, Santa Fe, NM 87502 USA. RP Morway, C (reprint author), Ctr Dis Control & Prevent, Ft Collins, CO 80521 USA. FU Eldorado Community Improvement Association FX We thank Molly Lauderbauch and Ying Bai for participating in field collection and laboratory analysis, Ken Gage and Rusty Enscore for support of the project, and Paul Ettestad and the New Mexico Department of Health for their support of the field work. We also thank the Eldorado Community Improvement Association for permission to trap in the subdivision and for their support of this study. NR 44 TC 20 Z9 22 U1 0 U2 4 PU SOC VECTOR ECOLOGY PI CORONA PA 1966 COMPTON AVE, CORONA, CA 92881 USA SN 1081-1710 J9 J VECTOR ECOL JI J. Vector Ecol. PD DEC PY 2008 VL 33 IS 2 BP 353 EP 364 PG 12 WC Entomology SC Entomology GA 395LB UT WOS:000262524500018 PM 19263856 ER PT J AU Shields, JM Hill, VR Arrowood, MJ Beach, MJ AF Shields, Joan M. Hill, Vincent R. Arrowood, Michael J. Beach, Michael J. TI Inactivation of Cryptosporidium parvum under chlorinated recreational water conditions SO JOURNAL OF WATER AND HEALTH LA English DT Article DE Cryptosporidium parvum; Ct value; hyperchlorination; parasitic protozoa; recreational waters; swimming pool ID SEQUENTIAL INACTIVATION; OOCYSTS; VIABILITY; INFECTIVITY; OZONE; ASSAYS; MONOCHLORAMINE; DISINFECTION; DIOXIDE AB Cryptosporidium is a chlorine-resistant protozoan parasite and the etiological agent in many disinfected recreational water outbreaks. While previous studies have reported disinfection Ct values for Cryptosporidium parvum using sodium hypochlorite, these studies have employed conditions and procedures which are not ideal for establishing public health remediation recommendations for chlorinated recreational water venues. In the present study, free chlorine Ct values were measured at pH 7.5 using young oocysts (<1 month old) and tissue culture to determine oocyst viability. Two different oocyst isolates were used: one originating from Iowa and one from Maine (USA). This study determined that the Ct values for a 3-log reduction in oocyst viability were 10,400 (Iowa) and 15,300 (Maine) at pH 7.5. These Ct values are higher than the Centers for Disease Control and Prevention (USA) currently recommends (Ct 9,600) for achieving a 3.0-log inactivation of Cryptosporidium oocysts during remediation of recreational water venues following fecal diarrhea accidents. C1 [Shields, Joan M.; Hill, Vincent R.; Arrowood, Michael J.; Beach, Michael J.] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Infect Dis, Atlanta, GA 30341 USA. RP Shields, JM (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Infect Dis, 4770 Buford Highway,Mail Stop F-36, Atlanta, GA 30341 USA. EM Jshields1@cdc.gov RI Hill, Vincent/G-1789-2012 OI Hill, Vincent/0000-0001-7069-7737 FU CDC Foundation FX This project was supported by the CDC Foundation through a grant from the National Swimming Pool Foundation and CEO Thomas Lachocki, Ph.D. The authors would like to especially thank Theresa Stevens for her help purifying oocysts and Long Ti Xie, PhD for his help and support with all matters relating to tissue culture. NR 25 TC 28 Z9 33 U1 2 U2 24 PU I W A PUBLISHING PI LONDON PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND SN 1477-8920 J9 J WATER HEALTH JI J. Water Health PD DEC PY 2008 VL 6 IS 4 BP 513 EP 520 DI 10.2166/wh.2008.068 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health; Microbiology; Water Resources SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Microbiology; Water Resources GA 377QZ UT WOS:000261267000008 PM 18401116 ER PT J AU Williamson, DM Abe, K Bean, C Ferre, C Henderson, Z Lackritz, E AF Williamson, Dhelia M. Abe, Karon Bean, Christopher Ferre, Cynthia Henderson, Zsakeba Lackritz, Eve TI Current Research in Preterm Birth SO JOURNAL OF WOMENS HEALTH LA English DT Article ID CELLULAR-IMMUNITY; UNITED-STATES; STRESS; WEIGHT; INFECTION; GENE; PROGESTERONE; POLYMORPHISM; DELIVERY; ASSOCIATION AB Preterm birth is one of the leading causes of infant mortality and the leading cause of infant morbidity in the United States. It accounts for >70% of neonatal deaths and almost half of long-term neurological disabilities. The Centers for Disease Control and Prevention (CDC) is collaborating with state health departments, universities, communities, and healthcare providers to understand why preterm births occur and how to address preterm birth risk factors. These collaborations include identification of genetic and other biological markers for the early detection of women at high risk of preterm birth; improving understanding of the relationships among psychosocial stress, immune and inflammatory responses, and preterm risk; and designing community strategies to improve the health of pregnant women. By conducting public health research activities that explore the genetic, biological, clinical, behavioral, social, and community determinants of preterm birth, CDC will continue to elucidate the complex interactions of these factors and how they influence preterm birth. C1 [Williamson, Dhelia M.; Abe, Karon; Ferre, Cynthia; Henderson, Zsakeba] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA. [Bean, Christopher] Ctr Dis Control & Prevent, Div Blood Disorders, Atlanta, GA 30341 USA. RP Williamson, DM (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, 4770 Buford Highway,MS K-23, Atlanta, GA 30341 USA. EM djw8@cdc.gov NR 34 TC 18 Z9 18 U1 0 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 J9 J WOMENS HEALTH JI J. Womens Health PD DEC PY 2008 VL 17 IS 10 BP 1545 EP 1549 DI 10.1089/jwh.2008.1045 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA 378OG UT WOS:000261331500001 PM 19000029 ER PT J AU O'Loughlin, R Hajjeh, R AF O'Loughlin, Rosalyn Hajjeh, Rana CA Hib Initiative TI Worldwide introduction and coverage of Haemophilus influenzae type b conjugate vaccine SO LANCET INFECTIOUS DISEASES LA English DT Letter C1 [O'Loughlin, Rosalyn] London Sch Hyg & Trop Med, London WC1, England. [Hajjeh, Rana] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP O'Loughlin, R (reprint author), London Sch Hyg & Trop Med, London WC1, England. EM Rosalyn.OLoughlin@lshtm.ac.uk NR 4 TC 4 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1473-3099 J9 LANCET INFECT DIS JI Lancet Infect. Dis. PD DEC PY 2008 VL 8 IS 12 BP 736 EP 736 DI 10.1016/S1473-3099(08)70263-9 PG 1 WC Infectious Diseases SC Infectious Diseases GA 375EN UT WOS:000261097000002 PM 19022186 ER PT J AU Agurs-Collins, T Khoury, MJ Simon-Morton, D Olster, DH Harris, JR Milner, JA AF Agurs-Collins, Tanya Khoury, Muin J. Simon-Morton, Denise Olster, Deborah H. Harris, Jennifer R. Milner, John A. TI Public Health Genomics: Translating Obesity Genomics Research Into Population Health Benefits SO OBESITY LA English DT Article; Proceedings Paper CT Gene-Nutrition and Gene-Nutrition and Gene-Physical Activitity Interactions in the Etiology of Obesity Workshop CY SEP 24-26, 2007 CL Bethesda, MD SP NIH, Natl Canc Inst, Div Canc Control & Populat Sci, NCI Div Nutr Sci, NIH Off Behav & Social Sci Res, Natl Heart, Lung & Blood Inst ID GENE-ENVIRONMENT INTERACTION; BODY-MASS INDEX; VARIANCE-COMPONENTS MODELS; FTO GENE; ADULT OBESITY; PHYSICAL-ACTIVITY; WIDE ASSOCIATION; EATING BEHAVIOR; COMMON DISEASES; LIFE-STYLE AB We examine how a public health genomics framework can be used to move genomic discoveries into clinical and public health practice for obesity prevention and treatment. There are four phases of translational research: T1: discovery to candidate health application; T2: health application to evidence-based practice guidelines; T3: practice guidelines to health practice; and T4: practice to population health impact. Types of multidisciplinary research and knowledge synthesis needed for each phase, as well as the importance of developing and disseminating evidence-based guidelines, are discussed. Because obesity genomics research is mostly in the discovery phase or in the very early phases of translation (T1), the authors present this framework to illustrate the range of translation activities needed to move genomic discoveries in obesity to actual applications that reduce the burden of obesity at the population level. C1 [Agurs-Collins, Tanya] NCI, Div Canc Control & Populat Sci, NIH, Bethesda, MD 20892 USA. [Khoury, Muin J.] Ctr Dis Control & Prevent, Natl Off Publ Hlth Genom, Coordinating Ctr Hlth Promot, Atlanta, GA USA. [Simon-Morton, Denise] NHLBI, Div Prevent & Populat Sci, NIH, Bethesda, MD 20892 USA. [Olster, Deborah H.] NIH, Off Behav & Social Sci Res, Bethesda, MD 20892 USA. [Harris, Jennifer R.] Norwegian Inst Publ Hlth, Oslo, Norway. [Harris, Jennifer R.] NIA, NIH, Bethesda, MD 20892 USA. [Milner, John A.] NCI, Nutr Sci Res Grp, Canc Prevent Div, NIH, Bethesda, MD 20892 USA. RP Agurs-Collins, T (reprint author), NCI, Div Canc Control & Populat Sci, NIH, Bethesda, MD 20892 USA. EM collinsta@mail.nih.gov FU Intramural NIH HHS [Z99 CA999999] NR 72 TC 13 Z9 14 U1 1 U2 5 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1930-7381 J9 OBESITY JI Obesity PD DEC PY 2008 VL 16 SU 3 BP S85 EP S94 DI 10.1038/oby.2008.517 PG 10 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA 379ON UT WOS:000261406200016 PM 19037221 ER PT J AU Jordan, HT Farley, MM Craig, A Mohle-Boetani, J Harrison, LH Petit, S Lynfield, R Thomas, A Zansky, S Gershman, K Albanese, BA Schaffner, W Schrag, SJ AF Jordan, Hannah T. Farley, Monica M. Craig, Allen Mohle-Boetani, Janet Harrison, Lee H. Petit, Susan Lynfield, Ruth Thomas, Ann Zansky, Shelley Gershman, Kenneth Albanese, Bernadette A. Schaffner, William Schrag, Stephanie J. CA CDCs Active Bacterial Core Surveil TI Revisiting the Need for Vaccine Prevention of Late-Onset Neonatal Group B Streptococcal Disease A Multistate, Population-Based Analysis SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE group B streptococcus; neonatal; surveillance; vaccine ID TOXOID CONJUGATE VACCINE; BREAST-MILK TRANSMISSION; PREGNANT-WOMEN; NOSOCOMIAL TRANSMISSION; RISK-FACTORS; COLONIZATION; MENINGITIS; INFECTION; INFANTS; SUSCEPTIBILITY AB Background: intrapartum antibiotic prophylaxis for neonatal group B streptococcal disease (GBS) effectively prevents disease among infants < 7 clays old, but there are no prevention strategies for late-onset GBS disease (Onset on days 7-89 of life). We describe trends in late-onset GBS over 16-year period to characterize disease burden and estimate vaccine preventability. Methods: We conducted active, population-based surveillance for invasive late-onset GBS disease in 10 states Front 1990 to 2005. A case was defined by GBS isolation front a normally sterile site oil day 7-89 of life in a surveillance area resident. Incidence rates were calculated per 1000 resident live births. Results: We identified 1726 cases; 26% presented with meningitis, and the ease fatality ratio was 4.3%. Incidence was similar throughout the study period. Incidence among black infants was approximately 3 times that among nonblack infants; the disparity persisted when data were stratified by gestational age. We estimate approximately 1300 cases of late-onset GBS occur annually in the United States. Birth at < 37 weeks gestation was common among case-infants (49%) and was associated with elevated case fatality (relative risk: 3.8; 95% confidence interval: 1.1-13.2). Of 653 serotyped isolates, serotypes III (53%), IA (24%), and V (13%) predominated. During 2003-2005, 81 (36%) of the 227 cases caused by serotypes III, IA, and V were born before 34 weeks gestation. Conclusions: The late-onset GBS disease burden remains substantial A trivalent vaccine Could be an effective prevention strategy. Because many cases were born preterm, reducing the opportunity for transplacental antibody transfer, adolescent immunization should be considered. C1 [Jordan, Hannah T.] Ctr Dis Control & Prevent, Resp Dis Branch, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30309 USA. [Jordan, Hannah T.] CDC, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA 30333 USA. [Farley, Monica M.] Emory Univ, Atlanta, GA 30322 USA. [Craig, Allen] Tennessee Dept Hlth, Nashville, TN USA. [Mohle-Boetani, Janet] Calif Dept Hlth, Berkeley, CA USA. [Harrison, Lee H.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Petit, Susan] Connecticut Dept Hlth, Hartford, CT USA. [Lynfield, Ruth] Minnesota Dept Hlth, Minneapolis, MN USA. [Thomas, Ann] Oregon Publ Hlth Div, Portland, OR USA. [Zansky, Shelley] New York State Dept Hlth, Albany, NY USA. [Gershman, Kenneth] Colorado Dept Publ Hlth & Environm, Denver, CO USA. [Albanese, Bernadette A.] New Mexico Dept Hlth, Santa Fe, NM USA. [Lynfield, Ruth] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA. RP Jordan, HT (reprint author), Ctr Dis Control & Prevent, Resp Dis Branch, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,MS C-23, Atlanta, GA 30309 USA. EM hjordan1@health.nyc.gov; zha6@cdc.gov FU Emerging Infections Prograill of the Centers for Disease Control and Prevention FX Financial support for ABCs is provided by the Emerging Infections Prograill of the Centers for Disease Control and Prevention. NR 48 TC 81 Z9 87 U1 1 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD DEC PY 2008 VL 27 IS 12 BP 1057 EP 1064 DI 10.1097/INF.0b013e318180b3b9 PG 8 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA 377BD UT WOS:000261225800003 PM 18989238 ER PT J AU Maahs, DM Snively, BM Beyer, J Imperatore, G Bell, R Mayer-Davis, EJ Dolan, LM Pettitt, DJ Hirsch, I Rodriguez, B Dabelea, D AF Maahs, David M. Snively, Beverly M. Beyer, Jennifer Imperatore, Giuseppina Bell, Ronny Mayer-Davis, Elizabeth J. Dolan, Lawrence M. Pettitt, David J. Hirsch, Irl Rodriguez, Beatriz Dabelea, Dana TI Weight and elevated albumin to creatinine ratio in youth with diabetes: the SEARCH for Diabetes in Youth study SO PEDIATRIC NEPHROLOGY LA English DT Article DE Albuminuria; Birth weight; Diabetes; Pediatric; Kidney disease; SEARCH ID LOW-BIRTH-WEIGHT; FETAL ORIGINS HYPOTHESIS; BLOOD-PRESSURE; RENAL-DISEASE; RISK-FACTOR; FOLLOW-UP; NORMOALBUMINURIC PATIENTS; MATERNAL RECALL; CHILDREN; EXCRETION AB Low birth weight (BWT) may contribute to kidney disease and could explain some of the variance in the development of early diabetic kidney disease. This hypothesis was tested in the multicenter SEARCH study (3,714 youth with diabetes < 20 years of age). A morning spot urine sample, laboratory and anthropometric data, and a medical history were obtained. Elevated albumin to creatinine ratio (ACR) was defined as >= 30 mcg albumin/mg creatinine, and BWT was categorized as low (< 2,500 g), reference (2,500-4,000 g), or high (> 4,000 g). The relationship of BWT to elevated ACR was analyzed using multiple logistic regression. In youth with diabetes, the prevalence of elevated ACR was 12.6% in those with low BWT, 9.7% in those with reference BWT, and 8.9% in those with high BWT. BWT category was not significantly associated with elevated ACR (p=0.23). Those with diabetes duration > 18 months (2,032) had the following association of BWT category with elevated ACR [odds ratio (OR)=1.64, 95% confidence interval (CI) 1.00-2.69, p=0.0503] for low BWT compared with reference BWT. Whereas low BWT may be a factor in kidney disease, little evidence was found of a relationship between low BWT and elevated ACR in this study population of youth with diabetes. C1 [Maahs, David M.] Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Aurora, CO 80045 USA. [Snively, Beverly M.; Beyer, Jennifer; Bell, Ronny] Wake Forest Univ, Sch Med, Winston Salem, NC 27109 USA. [Imperatore, Giuseppina] Ctr Dis Control & Prevent, Atlanta, GA USA. [Mayer-Davis, Elizabeth J.] Univ S Carolina, Columbia, SC 29208 USA. [Dolan, Lawrence M.] Childrens Hosp, Med Ctr, Cincinnati, OH USA. [Pettitt, David J.] Sansum Med Res Inst, Santa Barbara, CA USA. [Hirsch, Irl] Univ Washington, Sch Med, Seattle, WA USA. [Rodriguez, Beatriz] Pacific Hlth Res Inst, Honolulu, HI USA. [Dabelea, Dana] Univ Colorado, Hlth Sci Ctr, Dept Prevent Med & Biometr, Denver, CO 80262 USA. [Maahs, David M.] Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA. RP Maahs, DM (reprint author), Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, POB 6511,Mail Stop A140, Aurora, CO 80045 USA. EM David.Maahs@uchsc.edu FU K12 [DK063722-05, K23 DK075360]; Centers for Disease Control and Prevention [00097]; National Institute of Diabetes and Digestive and Kidney Diseases; Medical Center of South Carolina [M01 RR01070]; Cincinnati Children's Hospital [M01 RR08084]; Children's Hospital and Regional Medical Center and the University of Washington School of Medicine [M01RR00037, M01RR001271]; Colorado Pediatric General Clinical Research Center [M01 RR00069] FX Dr. Maahs was supported by the K12 training grant DK063722-05 and K23 DK075360. Grant Support: SEARCH for Diabetes in Youth is funded by the Centers for Disease Control and Prevention (PA number 00097) and supported by the National Institute of Diabetes and Digestive and Kidney Diseases. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the Centers for Disease Control and Prevention. The SEARCH for Diabetes in Youth Study is indebted to the many youth and their families, and their health care providers, whose participation made this study possible The authors wish to acknowledge the involvement of General Clinical Research Centers (GCRC) at the following institutions in the SEARCH for Diabetes in Youth Study: Medical Center of South Carolina (Grant Number M01 RR01070); Cincinnati Children's Hospital (Grant Number M01 RR08084); Children's Hospital and Regional Medical Center and the University of Washington School of Medicine (Grant Number M01RR00037 and M01RR001271); Colorado Pediatric General Clinical Research Center (Grant Number M01 RR00069). NR 37 TC 4 Z9 4 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0931-041X J9 PEDIATR NEPHROL JI Pediatr. Nephrol. PD DEC PY 2008 VL 23 IS 12 BP 2255 EP 2260 DI 10.1007/s00467-008-0921-z PG 6 WC Pediatrics; Urology & Nephrology SC Pediatrics; Urology & Nephrology GA 367HF UT WOS:000260542400021 PM 18607639 ER PT J AU Payne, DC Staat, MA Edwards, KM Szilagyi, PG Gentsch, JR Stockman, LJ Curns, AT Griffin, M Weinberg, GA Hall, CB Fairbrother, G Alexander, J Parashar, UD AF Payne, Daniel C. Staat, Mary Allen Edwards, Kathryn M. Szilagyi, Peter G. Gentsch, Jon R. Stockman, Lauren J. Curns, Aaron T. Griffin, Marie Weinberg, Geoffrey A. Hall, Caroline B. Fairbrother, Gerry Alexander, James Parashar, Umesh D. TI Active, Population-Based Surveillance for Severe Rotavirus Gastroenteritis in Children in the United States SO PEDIATRICS LA English DT Article DE rotavirus; acute gastroenteritis; disease burden; population-based surveillance ID POLYMERASE CHAIN-REACTION; COST-EFFECTIVENESS; HOSPITALIZATIONS; DIARRHEA; STRAINS; IDENTIFICATION; CENTERS; INFANTS; DISEASE; DEATHS AB OBJECTIVES. Routine vaccination of US infants against rotavirus was implemented in 2006, prompting the Centers for Disease Control and Prevention New Vaccine Surveillance Network to begin population-based acute gastroenteritis surveillance among US children < 3 years of age. This surveillance system establishes baseline estimates of rotavirus disease burden and allows for the prospective monitoring of rotavirus vaccination impact. METHODS. Eligible children with acute gastroenteritis (>= 3 episodes of diarrhea and/or any vomiting in a 24-hour period) who were hospitalized, were seen in emergency departments, or visited selected outpatient clinics in 3 US counties during the period of January through June 2006 were enrolled. Epidemiological and clinical information was obtained through parental interview and medical chart review, and stool specimens were tested for rotavirus with enzyme immunoassays. Rotavirus-positive specimens were genotyped by using reverse transcription-polymerase chain reaction assays. RESULTS. Stool specimens were collected from 516 of the 739 enrolled children with acute gastroenteritis (181 inpatient, 201 emergency department, and 134 outpatient) and 44% tested positive for rotavirus ( 227 of 516 specimens). The most common strain was P[8]G1 (84%), followed by P[4]G2 (5%) and P[6]G12 (4%). None of the 516 children had received rotavirus vaccine. The rotavirus detection rate was 50% for hospitalized acute gastroenteritis cases, 50% for emergency department visits, and 27% for outpatient visits. Rotavirus-related acute gastroenteritis cases were more likely than non-rotavirus-related acute gastroenteritis cases to present with vomiting, diarrhea, fever, and lethargy. Directly calculated, population-based rates for rotavirus hospitalizations and emergency department visits were 22.5 hospitalizations and 301.0 emergency department visits per 10 000 children < 3 years of age, respectively. A sentinel outpatient clinic visit rate of 311.9 outpatient visits per 10 000 children < 3 years of age was observed. CONCLUSIONS. Population-based, laboratory-confirmed rotavirus surveillance in the final rotavirus season before implementation of the US rotavirus vaccine program indicated a considerable burden of disease on the US health care system. Pediatrics 2008; 122: 1235-1243 C1 [Payne, Daniel C.; Stockman, Lauren J.; Curns, Aaron T.; Alexander, James; Parashar, Umesh D.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Epidemiol Branch, Atlanta, GA 30333 USA. [Gentsch, Jon R.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Gastroenteritis & Resp Viruses Lab Branch, Atlanta, GA 30333 USA. [Staat, Mary Allen; Fairbrother, Gerry] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati Childrens Hosp,Med Ctr, Cincinnati, OH USA. [Edwards, Kathryn M.; Griffin, Marie] Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN 37232 USA. [Edwards, Kathryn M.; Griffin, Marie] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN 37232 USA. [Edwards, Kathryn M.; Griffin, Marie] Vanderbilt Univ, Med Ctr, Dept Prevent Med, Nashville, TN 37232 USA. [Szilagyi, Peter G.; Weinberg, Geoffrey A.; Hall, Caroline B.] Univ Rochester, Sch Med & Dent, Dept Pediat, Rochester, NY 14642 USA. [Stockman, Lauren J.] Atlanta Res & Educ Fdn, Decatur, GA USA. RP Payne, DC (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Epidemiol Branch, 1600 Clifton Rd NE,MS-A34, Atlanta, GA 30333 USA. EM dvp6@cdc.gov NR 27 TC 100 Z9 103 U1 0 U2 5 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD DEC PY 2008 VL 122 IS 6 BP 1235 EP 1243 DI 10.1542/peds.2007-3378 PG 9 WC Pediatrics SC Pediatrics GA 377NP UT WOS:000261258200038 PM 19047240 ER PT J AU Kogan, MD Strickland, BB Blumberg, SJ Singh, GK Perrin, JM van Dyck, PC AF Kogan, Michael D. Strickland, Bonnie B. Blumberg, Stephen J. Singh, Gopal K. Perrin, James M. van Dyck, Peter C. TI A National Profile of the Health Care Experiences and Family Impact of Autism Spectrum Disorder Among Children in the United States, 2005-2006 SO PEDIATRICS LA English DT Article DE autism spectrum disorder; children with special health care needs; disability; national estimates; access to health care ID PERVASIVE DEVELOPMENTAL DISORDERS; PARENTAL REPORT; MEDICAL HOME; NEEDS; PREVALENCE; EXPENDITURES; ACCESS; SERVICES; SUPPORT; ASTHMA AB OBJECTIVES. We sought to examine the health care experiences of children with autism spectrum disorder and the impact of autism spectrum disorder on the family and to assess whether having a medical home is associated with less family impact. METHODS. We used the 2005-2006 National Survey of Children With Special Health Care Needs to compare 2088 children with special health care needs, aged 3 to 17 years, reported by their parents to have autism spectrum disorder, with children with special health care needs with "other emotional, developmental, or behavioral problems" (excluding autism spectrum disorder; n = 9534) and 26 751 other children with special health care needs. We used weighted logistic regression to examine unmet needs for specific health care and support services, delayed care, no usual care source or personal physician, difficulty receiving referrals, and financial, employment, or time problems because of child's care. RESULTS. Nationally, an estimated 535 000 children have special health care needs and autism spectrum disorder, a prevalence of 86 per 10 000 children aged 3 to 17 years. Among children with special health care needs, 5.6% have autism spectrum disorder. Compared with other children with special health care needs without emotional, developmental, or behavioral problems, children with special health care needs with autism spectrum disorder were more likely to have unmet needs for specific health care services, family support services, delayed or foregone care, difficulty receiving referrals, and care that is not family centered. Children with special health care needs with autism spectrum disorder were more likely to live in families that report financial problems, need additional income for the child's medical care, reduce or stop work because of the child's condition, spend >= 10 hours per week providing or coordinating care, and paid more than $1000 in the previous year for the child's care. The financial impacts of autism spectrum disorder were significantly more burdensome when children with special health care needs did not have a medical home. CONCLUSIONS. Children with special health care needs with autism spectrum disorder are significantly more likely to have problems regarding access to care and unmet needs, and their families have greater financial, employment, and time burdens compared with other children with special health care needs. Receipt of primary care in a medical home may reduce these burdens. Pediatrics 2008; 122: e1149-e1158 C1 [Kogan, Michael D.; Strickland, Bonnie B.; Singh, Gopal K.; van Dyck, Peter C.] US Hlth Resources & Serv Adm, Maternal & Child Hlth Bur, Rockville, MD 20857 USA. [Blumberg, Stephen J.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Perrin, James M.] Harvard Univ, Sch Med, Cambridge, MA 02138 USA. RP Kogan, MD (reprint author), US Hlth Resources & Serv Adm, Maternal & Child Hlth Bur, 5600 Fishers Lane,Room 18-41, Rockville, MD 20857 USA. EM mkogan@hrsa.gov NR 61 TC 166 Z9 166 U1 2 U2 22 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD DEC PY 2008 VL 122 IS 6 BP E1149 EP E1158 DI 10.1542/peds.2008-1057 PG 10 WC Pediatrics SC Pediatrics GA 377NP UT WOS:000261258200005 PM 19047216 ER PT J AU Kaleebu, P Abimiku, A El-Halabi, S Koulla-Shiro, S Mamotte, N Mboup, S Mugerwa, R Nkengasong, J Toure-Kane, C Tucker, T Wassenaar, D Williamson, C Wolday, D AF Kaleebu, Pontiano Abimiku, Alash'le El-Halabi, Shenaaz Koulla-Shiro, Sinata Mamotte, Nicole Mboup, Souleymane Mugerwa, Roy Nkengasong, John Toure-Kane, Coumba Tucker, Tim Wassenaar, Douglas Williamson, Carolyn Wolday, Dawit TI African AIDS Vaccine Programme for a Coordinated and Collaborative Vaccine Development Effort on the Continent SO PLOS MEDICINE LA English DT Editorial Material ID WOMEN C1 [Kaleebu, Pontiano] Uganda Virus Res Inst, Entebbe, Uganda. [Abimiku, Alash'le] Plateau State Human Virol Res Ctr, Inst Human Virol Nigeria, Jos, Nigeria. [El-Halabi, Shenaaz] Minist Hlth Botswana, Hlth Res Unit, Gaborone, Botswana. [Koulla-Shiro, Sinata] Univ Yaounde, Fac Med & Biomed Sci, Yaounde, Cameroon. [Mamotte, Nicole; Wassenaar, Douglas] Univ KwaZulu Natal, Sch Psychol, Pietermaritzburg, Kwazulu Natal, South Africa. [Mboup, Souleymane; Toure-Kane, Coumba] Univ Cheikh Anta Diop, Lab Bacteriol Virol, Dakar, Senegal. [Mugerwa, Roy] Makerere Univ, Dept Med, Kampala, Uganda. [Nkengasong, John] Ctr Dis Control & Prevent, Atlanta, GA USA. [Tucker, Tim] Sci Med Res Pty Ltd, Cape Town, Western Cape, South Africa. [Williamson, Carolyn] Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, Western Cape, South Africa. [Wolday, Dawit] Med Biotech Labs, Addis Ababa, Ethiopia. RP Kaleebu, P (reprint author), Uganda Virus Res Inst, Entebbe, Uganda. EM Pontiano.kaleebu@mrcuganda.org RI Wassenaar, Douglas/N-5301-2013; OI Wassenaar, Douglas/0000-0003-0839-9231; , Carolyn/0000-0003-0125-1226 FU Medical Research Council [MC_U950097145] NR 13 TC 7 Z9 7 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1549-1277 J9 PLOS MED JI PLos Med. PD DEC PY 2008 VL 5 IS 12 BP 1653 EP 1657 AR e236 DI 10.1371/journal.pmed.0050236 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 386WP UT WOS:000261913600008 PM 19053171 ER PT J AU Morrison, AC Forshey, BM Notyce, D Astete, H Lopez, V Rocha, C Carrion, R Carey, C Eza, D Montgomery, JM Kochel, TJ AF Morrison, Amy C. Forshey, Brett M. Notyce, Desiree Astete, Helvio Lopez, Victor Rocha, Claudio Carrion, Rebecca Carey, Cristhiam Eza, Dominique Montgomery, Joel M. Kochel, Tadeusz J. TI Venezuelan Equine Encephalitis Virus in Iquitos, Peru: Urban Transmission of a Sylvatic Strain SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID AEDES-AEGYPTI DIPTERA; AMAZON BASIN REGION; ENCEPHALOMYELITIS VIRUS; MOSQUITOS DIPTERA; VECTOR COMPETENCE; ENZOOTIC STRAINS; SUBTYPE IE; CULICIDAE; EMERGENCE; DENGUE AB Enzootic strains of Venezuelan equine encephalitis virus ( VEEV) have been isolated from febrile patients in the Peruvian Amazon Basin at low but consistent levels since the early 1990s. Through a clinic-based febrile surveillance program, we detected an outbreak of VEEV infections in Iquitos, Peru, in the first half of 2006. The majority of these patients resided within urban areas of Iquitos, with no report of recent travel outside the city. To characterize the risk factors for VEEV infection within the city, an antibody prevalence study was carried out in a geographically stratified sample of urban areas of Iquitos. Additionally, entomological surveys were conducted to determine if previously incriminated vectors of enzootic VEEV were present within the city. We found that greater than 23% of Iquitos residents carried neutralizing antibodies against VEEV, with significant associations between increased antibody prevalence and age, occupation, mosquito net use, and overnight travel. Furthermore, potential vector mosquitoes were widely distributed across the city. Our results suggest that while VEEV infection is more common in rural areas, transmission also occurs within urban areas of Iquitos, and that further studies are warranted to identify the precise vectors and reservoirs involved in urban VEEV transmission. C1 [Morrison, Amy C.; Forshey, Brett M.; Notyce, Desiree; Astete, Helvio; Lopez, Victor; Rocha, Claudio; Carrion, Rebecca; Montgomery, Joel M.; Kochel, Tadeusz J.] Naval Med Res Ctr Detachment, Lquitos, Peru. [Morrison, Amy C.; Forshey, Brett M.; Notyce, Desiree; Astete, Helvio; Lopez, Victor; Rocha, Claudio; Carrion, Rebecca; Montgomery, Joel M.; Kochel, Tadeusz J.] Naval Med Res Ctr Detachment, Lima, Peru. [Morrison, Amy C.; Eza, Dominique] Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA. [Notyce, Desiree] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Carey, Cristhiam] Direcc Ejecut Epidemiol Salud Loreto, Lquitos, Peru. [Montgomery, Joel M.] Ctr Dis Control, Atlanta, GA 30333 USA. RP Morrison, AC (reprint author), Naval Med Res Ctr Detachment, Lquitos, Peru. EM amy.aegypti@gmail.com FU United States Department of Defense FX This study was funded by the United States Department of Defense Global Emerging Infections Systems Research Program, WORK UNIT NUMBER: 847705.82000.25GB.B0016. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 54 TC 25 Z9 26 U1 0 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD DEC PY 2008 VL 2 IS 12 AR e349 DI 10.1371/journal.pntd.0000349 PG 14 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 406NA UT WOS:000263301000009 PM 19079600 ER PT J AU Simon, TR Ikeda, RM Smith, EP Reese, LE Rabiner, DL Miller-Johnson, S Winn, DM Dodge, KA Asher, SR Horne, AM Orpinas, P Martin, R Quinn, WH Tolan, PH Gorman-Smith, D Henry, DB Gay, FN Schoeny, M Farrell, AD Meyer, AL Sullivan, TN Allison, KW AF Simon, Thomas R. Ikeda, Robin M. Smith, Emilie Phillips Reese, Le'Roy E. Rabiner, David L. Miller-Johnson, Shari Winn, Donna-Marie Dodge, Kenneth A. Asher, Steven R. Horne, Arthur M. Orpinas, Pamela Martin, Roy Quinn, William H. Tolan, Patrick H. Gorman-Smith, Deborah Henry, David B. Gay, Franklin N. Schoeny, Michael Farrell, Albert D. Meyer, Aleta L. Sullivan, Terri N. Allison, Kevin W. TI The Multisite Violence Prevention Project: Impact of a Universal School-Based Violence Prevention Program on Social-Cognitive Outcomes SO PREVENTION SCIENCE LA English DT Article DE Aggression; Violence prevention; Middle school; Adolescent problem behavior; Social-cognitive ID AMERICAN ADOLESCENT MALES; AGGRESSIVE-BEHAVIOR; ANTISOCIAL-BEHAVIOR; REDUCING VIOLENCE; CHILDREN; INTERVENTION; RISK AB This study evaluated the impact of a universal school-based violence prevention program on social-cognitive factors associated with aggression and nonviolent behavior in early adolescence. The effects of the universal intervention were evaluated within the context of a design in which two cohorts of students at 37 schools from four sites (N=5,581) were randomized to four conditions: (a) a universal intervention that involved implementing a student curriculum and teacher training with sixth grade students and teachers; (b) a selective intervention in which a family intervention was implemented with a subset of sixth grade students exhibiting high levels of aggression and social influence; (c) a combined intervention condition; and (d) a no-intervention control condition. Short-term and long-term (i.e., 2-year post-intervention) universal intervention effects on social-cognitive factors targeted by the intervention varied as a function of students' pre-intervention level of risk. High-risk students benefited from the intervention in terms of decreases in beliefs and attitudes supporting aggression, and increases in self-efficacy, beliefs and attitudes supporting nonviolent behavior. Effects on low-risk students were in the opposite direction. The differential pattern of intervention effects for low- and high-risk students may account for the absence of main effects in many previous evaluations of universal interventions for middle school youth. These findings have important research and policy implications for efforts to develop effective violence prevention programs. C1 [Farrell, Albert D.; Meyer, Aleta L.; Sullivan, Terri N.; Allison, Kevin W.] Virginia Commonwealth Univ, Dept Psychol, Richmond, VA 23284 USA. [Simon, Thomas R.; Ikeda, Robin M.; Smith, Emilie Phillips; Reese, Le'Roy E.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Smith, Emilie Phillips] Penn State Univ, University Pk, PA 16802 USA. [Reese, Le'Roy E.] Morehouse Sch Med, Atlanta, GA USA. [Rabiner, David L.; Miller-Johnson, Shari; Winn, Donna-Marie; Dodge, Kenneth A.; Asher, Steven R.] Duke Univ, Durham, NC USA. [Winn, Donna-Marie] Univ N Carolina, Chapel Hill, NC 27515 USA. [Horne, Arthur M.; Orpinas, Pamela; Martin, Roy; Quinn, William H.] Univ Georgia, Athens, GA 30602 USA. [Quinn, William H.] Clemson Univ, Clemson, SC 29631 USA. [Tolan, Patrick H.; Gorman-Smith, Deborah; Henry, David B.; Gay, Franklin N.; Schoeny, Michael] Univ Illinois, Chicago, IL USA. [Meyer, Aleta L.] Natl Inst Drug Abuse, Lexington, KY USA. RP Farrell, AD (reprint author), Virginia Commonwealth Univ, Dept Psychol, POB 842018, Richmond, VA 23284 USA. EM afarrell@vcu.edu OI Tolan, Patrick/0000-0001-5669-8442 NR 48 TC 38 Z9 39 U1 1 U2 10 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1389-4986 J9 PREV SCI JI Prev. Sci. PD DEC PY 2008 VL 9 IS 4 BP 231 EP 244 DI 10.1007/s11121-008-0101-1 PG 14 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 369AX UT WOS:000260666100001 ER PT J AU Ko, JY Brown, DR Galuska, DA Zhang, J Blanck, HM Ainsworth, BE AF Ko, Jean Y. Brown, David R. Galuska, Deborah A. Zhang, Jian Blanck, Heidi M. Ainsworth, Barbara E. TI Weight loss advice US obese adults receive from health care professionals SO PREVENTIVE MEDICINE LA English DT Article DE Weight loss; Physician counseling; Physical activity; Diet; Obesity ID UNITED-STATES; MANAGEMENT; OVERWEIGHT; ATTITUDES; EXERCISE; VALIDITY; DIET AB Objectives. To estimate the prevalence of obese patients advised by health professionals about weight loss and weight loss strategies. Methods. A national sample or 1873 obese adults (body mass index >= 30 kg/m(2), >= 18 years) was surveyed. Multivariable linear regression was used to determine characteristics associated with receiving weight loss advice, and advice on diet and physical activity. Linear regression was used to evaluate characteristics associated with how much weight loss was advised. Results. Among obese adults visiting a physician (past 12 months), 39.0% reported being advised to lose weight. Men had lower odds of being advised to lose weight. Adults 40-49 years of age, reporting fair/poor health, and chronic diseases had greater odds of being advised to lose weight compared to referent groups. Among adults receiving advice on amount of weight to lose, a mean 20.9% total body weight reduction was recommended. Of those advised to lose weight, 64.2% were told to change their diet, 85.7% to increase physical activity, and 58.5% to use both strategies. Conclusions. Obese adults should be advised by health professionals more frequently about weight loss and the use of caloric reduction and increased physical activity as the recommended weight loss strategy. Published by Elsevier Inc. C1 [Brown, David R.; Galuska, Deborah A.; Zhang, Jian; Blanck, Heidi M.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA 30341 USA. [Ko, Jean Y.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD 21205 USA. [Ainsworth, Barbara E.] Arizona State Univ, Sch Appl Arts & Sci, Dept Exercise & Wellness, Mesa, AZ 85242 USA. RP Brown, DR (reprint author), Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, MS K46,4770 Buford Highway,NE, Atlanta, GA 30341 USA. EM dbrown@cdc.gov FU NIA NIH HHS [T32 AG027668]; ODCDC CDC HHS [U36 CD300430]; PHS HHS [U36-CCU-300430-24] NR 37 TC 45 Z9 46 U1 2 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0091-7435 J9 PREV MED JI Prev. Med. PD DEC PY 2008 VL 47 IS 6 BP 587 EP 592 DI 10.1016/j.ypmed.2008.09.007 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 385MX UT WOS:000261819400003 PM 18851991 ER PT J AU Strine, TW Mokdad, AH Balluz, LS Gonzalez, O Crider, R Berry, JT Kroenke, K AF Strine, Tara W. Mokdad, Ali H. Balluz, Lina S. Gonzalez, Olinda Crider, Raquel Berry, Joyce T. Kroenke, Kurt TI Depression and Anxiety in the United States: Findings From the 2006 Behavioral Risk Factor Surveillance System SO PSYCHIATRIC SERVICES LA English DT Article ID QUALITY-OF-LIFE; PATIENT HEALTH QUESTIONNAIRE; COMORBIDITY SURVEY REPLICATION; NATIONAL EPIDEMIOLOGIC SURVEY; PRIMARY-CARE PATIENTS; CARDIOVASCULAR-DISEASE; GENERAL-POPULATION; PRIME-MD; DISORDERS; PREVALENCE AB Objective: This study examined the unadjusted and adjusted prevalence estimates of depression and anxiety at the state level and examined the odds ratios of depression and anxiety for selected risk behaviors, obesity, and chronic diseases. Methods: The 2006 Behavioral Risk Factor Surveillance Survey, a random-digit-dialed telephone survey, collected depression and anxiety data from 217,379 participants in 38 states, the District of Columbia, Puerto Rico, and the U. S. Virgin Islands. Current depressive symptoms were assessed with the standardized and validated eight-item Patient Health Questionnaire, and lifetime diagnosis of depression and anxiety was assessed by two additional questions (one question for each diagnosis). Results: The overall prevalence of current depressive symptoms was 8.7% (range by state and territory, 5.3%-13.7%); of a lifetime diagnosis of depression, 15.7% (range, 6.8%-21.3%); and of a lifetime diagnosis of anxiety, 11.3% (range, 5.4%-17.2%). After sociodemographic characteristics, adverse health behaviors, and chronic illnesses were adjusted for, cardiovascular disease, diabetes, asthma, smoking, and obesity were all significantly associated with current depressive symptoms, a lifetime diagnosis of anxiety, and a lifetime diagnosis of depression. Physically inactive adults were significantly more likely than those who were physically active to have current depressive symptoms or a lifetime diagnosis of depression, whereas those who drank heavily were significantly more likely than those who did not to have current depressive symptoms or a lifetime diagnosis of anxiety. Conclusions: Depression and anxiety were strongly associated with common chronic medical disorders and adverse health behaviors. Examination of mental health should therefore be an integral component of overall health care. (Psychiatric Services 59: 1383-1390, 2008) C1 [Strine, Tara W.; Mokdad, Ali H.; Balluz, Lina S.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Behav Surveillance Branch, Atlanta, GA 30341 USA. [Gonzalez, Olinda; Crider, Raquel; Berry, Joyce T.] Subst Abuse & Mental Hlth Serv Adm, Rockville, MD USA. [Kroenke, Kurt] Indiana Univ, Sch Med, Dept Med, Indianapolis, IN USA. RP Strine, TW (reprint author), Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Behav Surveillance Branch, 4770 Buford Highway,NE,Mailstop K-66, Atlanta, GA 30341 USA. EM tws2@cdc.gov FU Eli Lilly and Company; Pfizer; Forest Laboratories FX Dr. Kroenke has received research support, honoraria, or both from Eli Lilly and Company, Pfizer, and Forest Laboratories. The other authors report no competing interests. NR 53 TC 135 Z9 140 U1 0 U2 12 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 1075-2730 J9 PSYCHIAT SERV JI Psychiatr. Serv. PD DEC PY 2008 VL 59 IS 12 BP 1383 EP 1390 DI 10.1176/appi.ps.59.12.1383 PG 8 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychiatry SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychiatry GA 376MI UT WOS:000261187300004 PM 19033164 ER PT J AU Roberge, MR Vojtko, MR Roberge, RJ Vojtko, RJ Landsittel, DP AF Roberge, Marc R. Vojtko, Mark R. Roberge, Raymond J. Vojtko, Richard J. Landsittel, Douglas P. TI Wearing an N95 Respirator Concurrently With a Powered Air-Purifying Respirator: Effect on Protection Factor SO RESPIRATORY CARE LA English DT Article DE N95; respirator; powered air-purifying respirator; protection factor ID INFECTIONS; SARS AB OBJECTIVE: To determine if using an N95 filtering face-piece respirator concurrently with a loose-fitting powered air-purifying respirator (PAPR) offers additional protection to the wearer. METHODS: We used a breathing mannequin programmed to deliver minute volumes of 25 L/min and 40 L/min. We measured the baseline protection factor of the PAPR with its motor operational and then deactivated (to simulate mechanical or battery failure). We tested 3 replicates of 3 different N95 models. We glued each N95 to the breathing mannequin and obtained a minimum protection factor of 100 at 25 L/min. We then placed the PAPR on the mannequin and took protection factor measurements with the N95-plus-PAPR combination, at 25 L/min and 40 L/min, with the PAPR operational and then deactivated. RESULTS: The N95 significantly increased the PAPR's protection factor, even with the PAPR deactivated. The effect was multiplicative, not merely additive. CONCLUSIONS: An N95 decreases the concentration of airborne particles inspired by the wearer of a PAPR. C1 [Roberge, Marc R.; Vojtko, Mark R.; Roberge, Raymond J.; Landsittel, Douglas P.] NIOSH, Natl Personal Protect Technol Lab, Ctr Dis Control & Prevent, Pittsburgh, PA 15236 USA. [Landsittel, Douglas P.] Duquesne Univ, Dept Math, Pittsburgh, PA 15219 USA. RP Roberge, RJ (reprint author), NIOSH, Natl Personal Protect Technol Lab, Ctr Dis Control & Prevent, POB 18070,626 Cochrans Mill Rd, Pittsburgh, PA 15236 USA. EM dtn0@cdc.gov NR 21 TC 1 Z9 1 U1 0 U2 0 PU DAEDALUS ENTERPRISES INC PI IRVING PA 9425 N MAC ARTHUR BLVD, STE 100, IRVING, TX 75063-4706 USA SN 0020-1324 J9 RESP CARE JI Respir. Care PD DEC PY 2008 VL 53 IS 12 BP 1685 EP 1690 PG 6 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 381BZ UT WOS:000261511100009 PM 19025703 ER PT J AU Sklaver, BA Clavel-Arcas, C Fandino-Losada, A Gutierrez-Martinez, MI Rocha-Castillo, J de Garcia, SM Concha-Eastman, A AF Sklaver, Benjamin A. Clavel-Arcas, Carme Fandino-Losada, Andres Gutierrez-Martinez, Maria Isabel Rocha-Castillo, Julio de Garcia, Silva Moran Concha-Eastman, Alberto TI The establishment of injury surveillance systems in Colombia, El Salvador, and Nicaragua (2000-2006) SO REVISTA PANAMERICANA DE SALUD PUBLICA-PAN AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article DE developing countries; health surveillance; epidemiologic surveillance; Colombia; El Salvador; Nicaragua ID UNINTENTIONAL INJURIES; DEVELOPING-COUNTRIES; MORTALITY C1 [Sklaver, Benjamin A.] Ctr Dis Control & Prevent, Int Emergency & Refugee Hlth Branch, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA. [Clavel-Arcas, Carme; Concha-Eastman, Alberto] Pan Amer Hlth Org, Washington, DC USA. [Fandino-Losada, Andres; Gutierrez-Martinez, Maria Isabel] Univ Valle, CISALVA Inst, Cali, Colombia. [Rocha-Castillo, Julio] Minist Hlth, Managua, Nicaragua. [de Garcia, Silva Moran] Minist Hlth, San Salvador, El Salvador. RP Sklaver, BA (reprint author), Ctr Dis Control & Prevent, Int Emergency & Refugee Hlth Branch, Natl Ctr Environm Hlth, 1600 Clifton Rd,Mailstop F60, Atlanta, GA 30333 USA. EM bsklaver@cdc.gov NR 28 TC 9 Z9 9 U1 0 U2 3 PU PAN AMER HEALTH ORGANIZATION PI WASHINGTON PA 525 23RD ST NW, WASHINGTON, DC 20037 USA SN 1020-4989 J9 REV PANAM SALUD PUBL JI Rev. Panam. Salud Publica PD DEC PY 2008 VL 24 IS 6 BP 379 EP 389 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 402EM UT WOS:000262997000002 PM 19178777 ER PT J AU Gawryszewski, VP Silva, MMA Malta, DC Kegler, SR Mercy, JA Mascarenhas, MDM Neto, OLM AF Gawryszewski, Vilma Pinheiro Alves da Silva, Marta Maria Malta, Deborah Carvalho Kegler, Scott R. Mercy, James A. Medeiros Mascarenhas, Marcio Denis Morais Neto, Otaliba Libanio TI Violence-related injury in emergency departments in Brazil SO REVISTA PANAMERICANA DE SALUD PUBLICA-PAN AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article DE Emergency medical services; violence; aggression; suicide; Brazil ID ALCOHOL AB Objective. This article describes the characteristics of violence-related injury (VRI) cases presenting at emergency departments (EDs) in Brazil and compares circumstances for assault-related and self-inflicted cases. Methods. The study is cross-sectional. The data describe cases seen in September 2006 in 62 EDs, representing all 26 states and the Federal District. A total of 4 835 case records were analyzed. Basic statistical tabulations were complemented by logistic regression analysis to assess potential associations between type of violence (assault or self-harm) and multiple factors. Results. Males comprised 72.8% of cases while those aged 20 to 29 comprised 35.4%. Alcohol use was reported or suspected in 42.7% of cases, more commonly among males. Assault victims comprised 91.4% of cases versus self-inflicted injuries, which accounted for 8.6%. Three-fourths of the assault victims were male, while over half of the self-inflicted injury victims were female. The leading mechanism for assaults was physical force/blunt objects (46.2%), whereas poisoning was the predominant mechanism for self-inflicted injuries (71.4%). Younger females were significantly more likely to have been victims of self-inflicted injuries than younger males, while younger males were more likely to have been victims of assault; this finding is more pronounced in cases where alcohol use was reported. Self-inflicted injuries were significantly more likely to occur in residences, while assaults were more likely to occur away from home. Conclusion. These results can improve understanding of the scope and characteristics of VRIs in Brazil (and thus contribute to national injury prevention efforts), and help identify areas for future research. C1 [Gawryszewski, Vilma Pinheiro] Sao Paulo State Hlth Dept, Sao Paulo, Brazil. [Alves da Silva, Marta Maria; Malta, Deborah Carvalho; Medeiros Mascarenhas, Marcio Denis; Morais Neto, Otaliba Libanio] Minist Hlth, Hlth Surveillance Secretariat CGDANT DASIS SVS, Dept Anal Hlth Condit, Brasilia, DF, Brazil. [Kegler, Scott R.; Mercy, James A.] Ctr Dis Control & Prevent, Div Violence Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA. RP Gawryszewski, VP (reprint author), Av Dr Arnaldo 351,Sala 609, BR-01246000 Sao Paulo, Brazil. EM vilmapg@saude.sp.gov.br RI Malta, Deborah/H-7880-2012 OI Malta, Deborah/0000-0002-8214-5734 NR 28 TC 13 Z9 15 U1 0 U2 3 PU PAN AMER HEALTH ORGANIZATION PI WASHINGTON PA 525 23RD ST NW, WASHINGTON, DC 20037 USA SN 1020-4989 J9 REV PANAM SALUD PUBL JI Rev. Panam. Salud Publica PD DEC PY 2008 VL 24 IS 6 BP 400 EP 408 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 402EM UT WOS:000262997000004 PM 19178779 ER EF