FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Dertzbaugh, MT West, MW AF Dertzbaugh, MT West, MW TI Mapping of protective and cross-reactive domains of the type A neurotoxin of Clostridium botulinum SO VACCINE LA English DT Article DE botulism; epitopes; vaccines ID ESCHERICHIA-COLI; TETANUS TOXIN; SEQUENCE; FRAGMENT; CELLS AB The purpose of this study was to identify the location of domains within the serotype A neurotoxin of Clostridium botulinum (BoNT\A) that conferred protection against botulism. The BoNT\A gene was subcloned into a series of 10 overlapping fragments that were expressed in Escherichia coli. The expressed proteins were partially purified and used to immunize mice. The resulting antisera were screened by immunoblotting analysis for the presence of BoNT\A-specific antibody. All fragments, except one, elicited antibody that recognized BoNT\A in an immunoblot. Serological screening identified several fragment-specific cross-reactive epitopes that were shared by heterologous serotypes of BoNT. Most of these epitopes were immunoreactive by enzyme-linked immunosorbent assay, but not by immunoblot. Only two fragments were shown to confer protection against BoNT\A intoxication. Both of these proteins were derived from segments of the heavy chain and encoded amino acid residues H-455-661 and H-1150-1289 of BoNT\A. RP Dertzbaugh, MT (reprint author), USA,MED RES INST INFECT DIS,DIV TOXICOL,FREDERICK,MD 21702, USA. NR 19 TC 61 Z9 63 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD NOV PY 1996 VL 14 IS 16 BP 1538 EP 1544 DI 10.1016/S0264-410X(96)00094-1 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA WC534 UT WOS:A1996WC53400009 PM 9014296 ER PT J AU Switkes, E Crognale, M Rabin, J Schneck, ME Adams, AJ AF Switkes, E Crognale, M Rabin, J Schneck, ME Adams, AJ TI Specificity and selectivity of chromatic visual evoked potentials - Reply SO VISION RESEARCH LA English DT Letter C1 UNIV CALIF SANTA CRUZ, DEPT PSYCHOBIOL, SANTA CRUZ, CA 95064 USA. UNIV CALIF BERKELEY, SCH OPTOMETRY, VISUAL SCI GRP, BERKELEY, CA 94720 USA. UNIV WASHINGTON, DEPT PSYCHOL, SEATTLE, WA 98195 USA. UNIV WASHINGTON, DEPT OPHTHALMOL, SEATTLE, WA 98195 USA. USA, ARL, FT RUCKER, AL 36362 USA. RP Switkes, E (reprint author), UNIV CALIF SANTA CRUZ, DEPT CHEM, SANTA CRUZ, CA 95064 USA. RI Crognale, Michael/K-4462-2012 FU NEI NIH HHS [EY07043, EY02271, EY00014] NR 14 TC 12 Z9 12 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0042-6989 J9 VISION RES JI Vision Res. PD NOV PY 1996 VL 36 IS 21 BP 3403 EP 3405 PG 3 WC Neurosciences; Ophthalmology SC Neurosciences & Neurology; Ophthalmology GA VR746 UT WOS:A1996VR74600004 PM 8977007 ER PT J AU Gaffin, SL Hubbard, R AF Gaffin, SL Hubbard, R TI Experimental approaches to therapy and prophylaxis for heat stress and heatstroke SO WILDERNESS & ENVIRONMENTAL MEDICINE LA English DT Review DE heatstroke; hyperthermia; stress; exercise; cytokines; lipopolysaccharide; heat shock proteins; fish oil; potassium; lipoproteins; nitric oxide; antilipopolysaccharide; phospholipase; hypothalamic-pituitary adrenal axis; lipopolysaccharide binding protein ID TUMOR-NECROSIS-FACTOR; RAT SOLEUS MUSCLE; WHOLE-BODY HYPERTHERMIA; SUPERIOR MESENTERIC-ARTERY; IMMUNE-SYSTEM INTERACTIONS; ENERGY DEPLETION MODEL; N-3 FATTY-ACIDS; LIPOPOLYSACCHARIDE CONCENTRATIONS; IMMUNOLOGICAL FUNCTIONS; ENDOTHERMIC METABOLISM AB New developments in the fields of biochemistry, physiology, sepsis, cancer therapy, and molecular genetics have led to opportunities for the development of new therapies and prophylaxes for heat illnesses and for improving human performance during conditions of environmental stress. These include antilipopolysaccharide ride agents, anticytokines, potassium channel agents, a diet rich in omega-3 fatty acids, and psychological conditioning. This review summarizes the backgrounds and recent findings in the above fields and provides specific suggestions for potential therapy and prophylaxis for classic and exertional heatstroke and for improving athletic performance. RP Gaffin, SL (reprint author), USA,ENVIRONM MED RES INST,COMPARAT PHYSIOL DIV,ENVIRONM PATHOPHYSIOL DIRECTORATE,NATICK,MA 01760, USA. NR 198 TC 4 Z9 4 U1 1 U2 3 PU CHAPMAN HALL LTD PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8HN SN 1080-6032 J9 WILD ENVIRON MED JI Wildern. Environ. Med. PD NOV PY 1996 VL 7 IS 4 BP 312 EP 334 DI 10.1580/1080-6032(1996)007[0312:EATTAP]2.3.CO;2 PG 23 WC Public, Environmental & Occupational Health; Sport Sciences SC Public, Environmental & Occupational Health; Sport Sciences GA WD878 UT WOS:A1996WD87800007 PM 11990129 ER PT J AU Rosa, C AF Rosa, C TI Impact of pregnancy and pregnancy complications during deployment: The role of pregnancy screening SO WOMENS HEALTH ISSUES LA English DT Article; Proceedings Paper CT Forum on the Health of Women in the Military - Executive Summary CY JUN 17-19, 1996 CL UNIFORMED SERV UNIV HLTH SCI, BETHESDA, MD HO UNIFORMED SERV UNIV HLTH SCI RP Rosa, C (reprint author), USA,NATL CAPITAL INTEGRATED OBSTET & GYNECOL RESIDENC,BETHESDA,MD, USA. NR 0 TC 3 Z9 3 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 1049-3867 J9 WOMEN HEALTH ISS JI Womens Health Iss. PD NOV-DEC PY 1996 VL 6 IS 6 BP 361 EP 363 PG 3 WC Public, Environmental & Occupational Health; Women's Studies SC Public, Environmental & Occupational Health; Women's Studies GA VY285 UT WOS:A1996VY28500010 PM 9044666 ER PT J AU King, N AF King, N TI Perspectives on nutritional issues of military women SO WOMENS HEALTH ISSUES LA English DT Article; Proceedings Paper CT Forum on the Health of Women in the Military - Executive Summary CY JUN 17-19, 1996 CL UNIFORMED SERV UNIV HLTH SCI, BETHESDA, MD HO UNIFORMED SERV UNIV HLTH SCI RP King, N (reprint author), BROOKE ARMY MED CTR,CLIN DIETET BRANCH,NUTR CARE DIV,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 1049-3867 J9 WOMEN HEALTH ISS JI Womens Health Iss. PD NOV-DEC PY 1996 VL 6 IS 6 BP 368 EP 371 PG 4 WC Public, Environmental & Occupational Health; Women's Studies SC Public, Environmental & Occupational Health; Women's Studies GA VY285 UT WOS:A1996VY28500013 PM 9044669 ER PT J AU Chen, PL Tomov, IV Dvornikov, AS Nakashima, M Roach, JF Alabran, DM Rentzepis, PM AF Chen, PL Tomov, IV Dvornikov, AS Nakashima, M Roach, JF Alabran, DM Rentzepis, PM TI Picosecond kinetics and reverse saturable absorption of meso-substituted tetrabenzoporphyrins SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID EXCITED-STATE; RELAXATION MECHANISM; OPTICAL LIMITER; KINGS COMPLEX; PORPHYRINS; METALLOPORPHYRIN; PHOTOPHYSICS; 3RD-ORDER; SOLVENT; C-60 AB The mechanism of reverse saturable absorption of meso-substituted tetrabenzoporphyrins was studied by means of picosecond transient spectroscopy. Characteristic (1)(pi,pi*), (3)(pi,pi*), and (d,d) transitions have been observed. The kinetics of the excited states vary with metal substitution. The nonlinear transmission of benzoporphyrins was measured, and the excited-state absorption was determined to be the dominant optical limiting mechanism. The results agreed very well with a five-level model. C1 UNIV CALIF IRVINE,DEPT CHEM,IRVINE,CA 92717. USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. RI Chen, Peilin/E-2728-2010 OI Chen, Peilin/0000-0003-4154-0487 NR 36 TC 77 Z9 77 U1 0 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD OCT 31 PY 1996 VL 100 IS 44 BP 17507 EP 17512 DI 10.1021/jp9615161 PG 6 WC Chemistry, Physical SC Chemistry GA VR076 UT WOS:A1996VR07600012 ER PT J AU Donovan, WH White, WE AF Donovan, WH White, WE TI A semiempirical study of 2,2'-dichlorodiethyl sulfide S(N)2 and neighboring group hydrolysis reaction mechanisms in the gas phase and in aqueous solution SO THEOCHEM-JOURNAL OF MOLECULAR STRUCTURE LA English DT Article DE semiempirical calculation; hydrolysis reaction mechanism; 2,2'-dichlorodiethyl sulfide ID INTRAMOLECULAR SN2 REACTIONS; CHEMICAL WARFARE AGENTS; SULFUR MUSTARD; ANCHIMERIC ASSISTANCE; MOLECULAR MECHANICS; TRANSITION-STATE; FREE-ENERGIES; SOLVATION; DERIVATIVES; PM3-SM3 AB A PM3 and SM3-PM3 semiempirical molecular orbital study of the 2,2'-dichlorodiethyl sulfide conventional S(N)2 and neighboring group hydrolysis reaction mechanisms in the gas phase and in aqueous solution is described. The calculations predict substantially faster reactions in aqueous solution, with the neighboring group mechanism always being preferred. Detailed consideration is given to the geometries, relative energies, and partial atomic charges of all species involved in the reaction mechanisms considered and the extent to which aqueous solvation impacts these quantities. The results are consistent with expectation and with reported calculations concerning the intramolecular S(N)2 reaction of 2-chloroethyl methyl sulfide. We also present the lowest energy mustard chlorohydrin structures according to PM3 and AM1 conformational analysis. C1 USA,EDGEWOOD RES DEV & ENGN CTR,SCBRD,RTC,ABERDEEN PROVING GROUND,MD 21010. NR 37 TC 2 Z9 2 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 THEOCHEM-J MOL STRUC JI Theochem-J. Mol. Struct. PD OCT 30 PY 1996 VL 370 IS 2-3 BP 209 EP 220 PG 12 WC Chemistry, Physical SC Chemistry GA WD056 UT WOS:A1996WD05600010 ER PT J AU Urban, JJ Famini, GR AF Urban, JJ Famini, GR TI Conformational analysis - Preface SO THEOCHEM-JOURNAL OF MOLECULAR STRUCTURE LA English DT Editorial Material C1 USA,EDGEWOOD RES,SCBRD,ASI,ABERDEEN PROVING GROUND,MD 21010. RP Urban, JJ (reprint author), USN ACAD,DEPT CHEM,121 BLAKE RD,ANNAPOLIS,MD 21402, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 THEOCHEM-J MOL STRUC JI Theochem-J. Mol. Struct. PD OCT 30 PY 1996 VL 370 IS 2-3 BP R7 EP R7 PG 1 WC Chemistry, Physical SC Chemistry GA WD056 UT WOS:A1996WD05600001 ER PT J AU Gurevich, VL Pevzner, VB Iafrate, GJ AF Gurevich, VL Pevzner, VB Iafrate, GJ TI Giant quantum oscillations of acoustoelectric effect in nanostructures SO PHYSICAL REVIEW LETTERS LA English DT Article ID HETEROSTRUCTURES; TRANSPORT AB We work out a theory of the acoustoelectric effect in nanostructures under the ballistic conductance regime. The ultrasonic wavelength is assumed to be much smaller than the longitudinal dimension of the microstructure. We predict giant quantum oscillation of the acoustoelectric current under gate voltage variation. By this we mean that the maxima of the oscillatory part far exceed the minima. The effect can be used for the investigation of the electron spectrum of microstructures. C1 N CAROLINA STATE UNIV,DEPT ELECT ENGN,RALEIGH,NC 27695. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP Gurevich, VL (reprint author), AF IOFFE PHYS TECH INST,DIV SOLID STATE PHYS,POLITEKHNICHESKAYA 26,ST PETERSBURG 194021,RUSSIA. RI V*L Gurevich, Vadim/E-9453-2014 NR 13 TC 19 Z9 19 U1 0 U2 0 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD OCT 28 PY 1996 VL 77 IS 18 BP 3881 EP 3884 DI 10.1103/PhysRevLett.77.3881 PG 4 WC Physics, Multidisciplinary SC Physics GA VP225 UT WOS:A1996VP22500048 ER PT J AU Chylek, P Lesins, GB Videen, G Wong, JGD Pinnick, RG Ngo, D Klett, JD AF Chylek, P Lesins, GB Videen, G Wong, JGD Pinnick, RG Ngo, D Klett, JD TI Black carbon and absorption of solar radiation by clouds SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID ELEMENTAL CARBON; PARTICULATE CARBON; GRAPHITIC CARBON; UNITED-STATES; AEROSOL; SCATTERING; PARTICLES; SOOT; INCLUSION; DROPLETS AB The exact solution of the scattered electromagnetic field from a water droplet containing an arbitrarily located spherical black carbon particle is used to investigate the effect of black carbon on the absorption of solar radiation by clouds. When droplet absorption is averaged over all possible locations of black carbon within a droplet, the averaged absorption is close to the value calculated using the effective medium approximation. The preferential black carbon location on the top or close to the bottom of the droplet leads to an increased absorption. The estimated upper bound on the increased absorption of solar radiation (global and annual average) is 1-3 W/m(2) over the absorption of pure water clouds. C1 PAR ASSOCIATES, LAS CRUCES, NM 88011 USA. USA, EDGEWOOD RES & DEV CTR, ABERDEEN PROVING GROUND, ABERDEEN, MD 21010 USA. USA, RES LAB, WHITE SANDS MISSILE RANGE, NM 88002 USA. NEW MEXICO STATE UNIV, DEPT PHYS, LAS CRUCES, NM 88003 USA. SUNY ALBANY, DEPT ATMOSPHER SCI, ALBANY, NY 12222 USA. RP Chylek, P (reprint author), DALHOUSIE UNIV, DEPT PHYS & OCEANOG, ATMOSPHER SCI PROGRAM, HALIFAX, NS B3H 3J5, CANADA. NR 37 TC 90 Z9 90 U1 1 U2 12 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD OCT 27 PY 1996 VL 101 IS D18 BP 23365 EP 23371 DI 10.1029/96JD01901 PG 7 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA VP976 UT WOS:A1996VP97600008 ER PT J AU Killion, SL Hunter, GC Eskelson, CD Dubick, MA Putnam, CW Hall, KA Luedke, CA Misiorowski, RL Schilling, JD McIntyre, KE AF Killion, SL Hunter, GC Eskelson, CD Dubick, MA Putnam, CW Hall, KA Luedke, CA Misiorowski, RL Schilling, JD McIntyre, KE TI Vitamin E levels in human atherosclerotic plaque: The influence of risk factors SO ATHEROSCLEROSIS LA English DT Article DE vitamin E; atherosclerotic risk factor; lipid peroxides ID LOW-DENSITY-LIPOPROTEIN; CORONARY HEART-DISEASE; LIPID-PEROXIDATION; ALPHA-TOCOPHEROL; OXIDATIVE MODIFICATION; FREE-RADICALS; FATTY-ACIDS; ANTIOXIDANTS; SELENIUM; SUPPLEMENTATION AB Recent studies suggest that vitamin E may be an important preventative factor in the development and progression of atherosclerosis. In order to more clearly define the role of vitamin E in atherosclerosis, we measured vitamin E, conjugated dienes, and lipid flurochromes, as well as cholesterol, triglycerides and phospholipid in arterial and venous tissue of 83 patients. Serum cholesterol and triglyceride levels were significantly higher (P < 0.05) in patients with aortic occlusive (AIOD) and aneurysmal (AAA) disease than in control organ donors (OD). Tissue cholesterol concentrations were significantly elevated in AAA tissue when compared to OD and tissue from patients with peripheral occlusive disease (POD). Tissue from patients with AIOD contained greater concentrations of phospholipid BL) than were measured in patients with POD and in OD. Vitamin E concentrations were highest in POD tissue and approximately 3.0, 2.0, and 1.6 fold greater than OD, AIOD and AAA tissue respectively. Diene conjugates and lipid flurochromes, measures of early and intermediate products of lipid peroxidation, were markedly elevated in all diseased arterial tissue compared to controls. There were no significant differences in tissue or serum lipid levels between saphenous vein (SVBG) and diseased vein grafts (DVG). However, conjugated diene concentrations were elevated in DVG compared to SVBG. Vitamin E levels were significantly elevated in diseased arterial and venous tissue (AIOD, AAA, POD, DVG) removed from patients with diabetes (P = 0.013) and hypertension (P = 0.049) compared to those without these risk factors. Diabetes was the only risk factor associated with significantly increased (P= 0.005) levels of vitamin E when only data from atherosclerotic arterial tissue (AAA, POD, AIOD) were analyzed. These preliminary data provide additional evidence of altered vitamin E metabolism and free radical processes in the tissues of patients with various manifestations of atherosclerosis. C1 VET AFFAIRS MED CTR, DEPT SURG, VASC SURG SECT, TUCSON, AZ 85724 USA. UNIV WASHINGTON, SEATTLE, WA 98195 USA. UNIV ARIZONA, HLTH SCI CTR, TUCSON, AZ 85724 USA. USA, INST SURG RES, MTR BRANCH, FT SAM HOUSTON, TX 78234 USA. NR 46 TC 15 Z9 15 U1 0 U2 2 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0021-9150 J9 ATHEROSCLEROSIS JI Atherosclerosis PD OCT 25 PY 1996 VL 126 IS 2 BP 289 EP 297 DI 10.1016/0021-9150(96)05918-7 PG 9 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA VN929 UT WOS:A1996VN92900012 PM 8902154 ER PT J AU Hudgins, WR Fibach, E Safaya, S Rieder, RF Miller, AC Samid, D AF Hudgins, WR Fibach, E Safaya, S Rieder, RF Miller, AC Samid, D TI Transcriptional upregulation of gamma-globin by phenylbutyrate and analogous aromatic fatty acids SO BIOCHEMICAL PHARMACOLOGY LA English DT Article DE erythroid precursor; hemoglobin F; beta-hemoglobinopathies; aromatic fatty acids; phenylbutyrate; butyrate responsive promoter ID FETAL HEMOGLOBIN PRODUCTION; SICKLE-CELL-ANEMIA; ORAL SODIUM PHENYLBUTYRATE; BETA-THALASSEMIA; ERYTHROID PRECURSORS; GENE-EXPRESSION; LIQUID CULTURE; GROWTH ARREST; PHENYLACETATE; BUTYRATE AB Phenylbutyrate has been shown recently to induce fetal hemoglobin (HbF) production in patients with sickle cell anemia and beta thalassemia. We have now examined related aromatic fatty acids in order to define the range of active structures and identify plausible mechanisms of action. Structure-function analysis revealed that for effective stimulation of HbF in erythroid precursors: (1) the ideal length for the aliphatic side chain is four carbons; (2) oxygen or sulfur substitutions in the carboxylic chain are allowed, as evidenced by the equal or increased activity of phenoxypropionate, benzylthioglycolate, and benzyloxyacetate compared with phenylbutyrate; and (3) blocking the carboxylate group by conversion to the amide form greatly reduces potency. Molecular analysis indicated that the prototype agent, phenylbutyrate, increases HbF production through transcriptional activation of the gamma-globin gene. The latter contains a butyrate responsive promoter known to up-regulate transcription in the presence of short-chain fatty acids of three to five carbons. To determine whether stimulation of an element in this promoter by phenylbutyrate and its analogues might contribute to their mechanism of action, we used a transient expression system involving K562 erythroleukemia cells transfected with a luciferase reporter gene driven by the minimum gamma-globin promoter. Transcriptional activation in this experimental system correlated well with the capacity of an aromatic fatty acid to increase HbF production in erythroid precursors (r = 0.94). Our studies identify potent analogues of phenylbutyrate for the treatment of P-chain hemoglobinopathies, and suggest that stimulation of a butyrate responsive promoter may be responsible for their activity. C1 UNIV VIRGINIA,CTR CANC,CHARLOTTESVILLE,VA 22908. NCI,CLIN PHARMACOL BRANCH,BETHESDA,MD 20892. NIDDKD,BIOL CHEM LAB,NIH,BETHESDA,MD 20892. HADASSAH UNIV HOSP,DEPT HEMATOL,IL-91120 JERUSALEM,ISRAEL. SUNY HLTH SCI CTR,DEPT MED,BROOKLYN,NY. USA,ARMED FORCES RADIAT RES INST,RADIAT BIOCHEM DEPT,BETHESDA,MD. NR 31 TC 21 Z9 21 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0006-2952 J9 BIOCHEM PHARMACOL JI Biochem. Pharmacol. PD OCT 25 PY 1996 VL 52 IS 8 BP 1227 EP 1233 DI 10.1016/0006-2952(96)00476-5 PG 7 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA VN484 UT WOS:A1996VN48400012 PM 8937430 ER PT J AU Sirenko, YM Jeon, JB Kim, KW Littlejohn, MA Stroscio, MA AF Sirenko, YM Jeon, JB Kim, KW Littlejohn, MA Stroscio, MA TI Strain effects on valence band structure in wurtzite GaN quantum wells SO APPLIED PHYSICS LETTERS LA English DT Article AB The effect of strain on valence band spectra in both bulk and in pseudomorphic GaN quantum wells is studied theoretically using recent experimental results for deformation potential constants. Wave functions and dispersion curves for A-, B- and C-hole subbands are obtained from linear combination of bulk analytical solutions for the 3X3 wurtzite block-Hamiltonian. A detailed analysis is presented for the dependence of hole spectrum on quantum well width, depth, and strain due to lattice mismatch. (C) 1996 American Institute of Physics. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP Sirenko, YM (reprint author), N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695, USA. NR 23 TC 26 Z9 26 U1 1 U2 4 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 21 PY 1996 VL 69 IS 17 BP 2504 EP 2506 DI 10.1063/1.117721 PG 3 WC Physics, Applied SC Physics GA VN898 UT WOS:A1996VN89800018 ER PT J AU Anker, DS AF Anker, DS TI Optical parametric amplifiers: A discrete dynamical model of singly resonant operation leading to a novel approach to the design of systems for high-efficiency amplification (vol 35, pg 1452, 1996) SO APPLIED OPTICS LA English DT Correction, Addition RP Anker, DS (reprint author), USA,RES LAB,AMSRL,EP,EJ,FT BELVOIR,VA 22060, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD OCT 20 PY 1996 VL 35 IS 30 BP 5960 EP 5960 DI 10.1364/AO.35.005960 PG 1 WC Optics SC Optics GA VN212 UT WOS:A1996VN21200013 PM 21127608 ER PT J AU Feller, SE Pastor, RW Rojnuckarin, A Bogusz, S Brooks, BR AF Feller, SE Pastor, RW Rojnuckarin, A Bogusz, S Brooks, BR TI Effect of electrostatic force truncation on interfacial and transport properties of water SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID MOLECULAR-DYNAMICS SIMULATION; LONG-RANGE INTERACTIONS; PARTICLE MESH EWALD; COMPUTER-SIMULATION; BOUNDARY-CONDITIONS; LIQUID/LIQUID INTERFACES; PHOSPHOLIPID-BILAYERS; SURFACE-TENSION; LIPID BILAYERS; MONTE-CARLO AB The importance of accurately accounting for all Coulombic forces in molecular dynamics simulations of water at interfaces is demonstrated by comparing the Ewald summation technique with various spherical truncation methods, The increased structure induced by truncation methods at 12 Angstrom leads to water/vapor surface tensions and surface potentials that are respectively 50% and 100% greater than obtained with Ewald. The orientational polarization of water at the lipid/water interface is analyzed within the Marcelja-Radic theory of the hydration force, yielding decay parameters of 2.6 and 1.8 Angstrom for spherical truncation and Ewald, respectively, as compared with 1.7-2.1 Angstrom obtained from experiment. Bulk water transport properties such as the viscosity and diffusion constants differ by as much as 100% between simulations carried out with and without truncation; this may be related to ordering in the neighborhood of the cutoff radius. The diffusion constant calculated from the Ewald simulation is significantly further from experiment than the cutoff result, pointing out the need to reparametrize the TIP3P water model for use with Ewald summation. Appendices describe a method for carrying out the Ewald summation on a distributed memory parallel computer and other computational details relevant when simulating large systems. C1 US FDA,CTR BIOL EVALUAT & RES,BIOL LAB,ROCKVILLE,MD 20852. UNIV WISCONSIN,DEPT CHEM ENGN,MADISON,WI 53706. WALTER REED ARMY INST RES,DEPT GASTROENTEROL,WASHINGTON,DC 20307. NIH,DIV COMP RES & TECHNOL,STRUCT BIOL LAB,BETHESDA,MD 20892. NR 52 TC 265 Z9 268 U1 1 U2 29 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD OCT 17 PY 1996 VL 100 IS 42 BP 17011 EP 17020 DI 10.1021/jp9614658 PG 10 WC Chemistry, Physical SC Chemistry GA VN802 UT WOS:A1996VN80200034 ER PT J AU Scott, DS Arora, UK Farb, A Virmani, R Weissman, NJ AF Scott, DS Arora, UK Farb, A Virmani, R Weissman, NJ TI Calcified luminal surface area: Pathologic validation of a new method to quantify coronary calcification by intravascular ultrasound SO CIRCULATION LA English DT Meeting Abstract C1 GEORGETOWN MED CTR,WASHINGTON,DC. USA,INST PATHOL,WASHINGTON,DC 20310. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 15 PY 1996 VL 94 IS 8 SU S BP 449 EP 449 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA VN119 UT WOS:A1996VN11900448 ER PT J AU Laird, JR Carter, AJ Kovach, JA Gorman, PD Lansky, AJ Burwell, NB Pierre, AB Fischell, TA AF Laird, JR Carter, AJ Kovach, JA Gorman, PD Lansky, AJ Burwell, NB Pierre, AB Fischell, TA TI Early results with the coronary pullback atherectomy catheter SO CIRCULATION LA English DT Meeting Abstract C1 WASHINGTON HOSP CTR,WASHINGTON,DC 20010. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. VANDERBILT UNIV,NASHVILLE,TN. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 15 PY 1996 VL 94 IS 8 SU S BP 494 EP 494 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA VN119 UT WOS:A1996VN11900493 ER PT J AU Barth, J AF Barth, J TI Navigating the mortgage maze: An interactive high-tech guide to financing your future - Turnauer,AE SO LIBRARY JOURNAL LA English DT Book Review RP Barth, J (reprint author), US MIL ACAD LIB,W POINT,NY, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 1996 VL 121 IS 17 BP 69 EP 70 PG 2 WC Information Science & Library Science SC Information Science & Library Science GA VN323 UT WOS:A1996VN32300121 ER PT J AU Polly, DW Meter, JJ Brueckner, R Asplund, L vanDam, BE AF Polly, DW Meter, JJ Brueckner, R Asplund, L vanDam, BE TI The effect of intraoperative blood loss on serum cefazolin level in patients undergoing instrumented spinal fusion - A prospective, controlled study SO SPINE LA English DT Article DE blood loss; cefazolin; pharmacokinetics; spine fusion ID PHARMACOKINETICS; SURGERY; ANTIBIOTICS; INFECTION AB Study Design. This study is a prospective, controlled study of the effect of intraoperative and postoperative blood loss during spinal surgery on serum cefazolin level. Objectives. To determine what effect, if any, intraoperative blood loss has on serum antibiotic levels, and to determine ii adjustment of the dose or dose interval is appropriate in operative cases of significant blood loss. Summary of Background Data. The problem of infection at the operative site after posterior spinal fusion with internal fixation is significant. It commonly has been accepted that blood loss results in a more rapid clearance of antibiotic. Methods. Nineteen patients scheduled for elective spinal fusion with internal fixation were enrolled in this study. Each patient served as his or her own control. Baseline cefazolin clearance was determined the week before surgery. Cefazolin clearance again was determined intraoperatively. Blood loss was recorded throughout the procedure. Results. The mean blood loss was 650 mL. There was no significant difference between preoperative and intraoperative cefazolin clearance, and there was no correlation between blood loss and cefazolin level. Conclusions. It is not necessary to give cefazolin at a dosing interval of less than 4 hours with blood losses of up to 1200 mL. This will maintain the antibiotic concentration well above the minimum inhibitory concentration. C1 WALTER REED ARMY INST RES,WASHINGTON,DC. SCRIPPS MEM XIMED MED CTR,LA JOLLA,CA. RP Polly, DW (reprint author), WALTER REED ARMY MED CTR,ORTHOPAED SURG SERV,WASHINGTON,DC 20307, USA. NR 32 TC 19 Z9 19 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0362-2436 J9 SPINE JI SPINE PD OCT 15 PY 1996 VL 21 IS 20 BP 2363 EP 2367 DI 10.1097/00007632-199610150-00011 PG 5 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA VN873 UT WOS:A1996VN87300011 PM 8915072 ER PT J AU Chiang, JC Li, SS Tidrow, MZ Ho, P Tsai, M Lee, CP AF Chiang, JC Li, SS Tidrow, MZ Ho, P Tsai, M Lee, CP TI A voltage-tunable multicolor triple-coupled InGAs/GaAs/AlGaAs quantum-well infrared photodetector for 8-12 mu m detection SO APPLIED PHYSICS LETTERS LA English DT Article ID GAAS/ALGAAS; CAMERA AB A voltage-tunable multicolor triple-coupled quantum-well infrared photodetector (TC-QWIP) has been developed for 8-12 mu m detection. The TC-QWIP consists of three coupled quantum wells formed by an enlarged Si-doped InxGa1-xAs quantum well and two undoped GaAs quantum wells separated by two thin AlyGa1-yAs barriers. Two TC-QWIP structures with varying indium and aluminum compositions were designed and demonstrated. Due to the strong coupling effect of the asymmetrical quantum wells, three bound states (E(1), E(2), E(3)) are formed inside the quantum wells of the TC-QWIP. The main detection peak wavelength is due to E(1)-->E(3) bound states transition for both devices, while two secondary detection peaks due to E(1)-->E(2) and E(1)-->E(c) continuum states transitions under different biases were also observed. In addition, a strong quantum-confined Stark shift effect for the E(1)-->E(3) transition was observed in the wavelength range of 8.2-9.1 and 10.8-11.5 mu m for QWIP-A and QWIP-B, respectively; both devices exhibit a linear dependence of detection peak wavelength on the applied bias voltage. A spectral responsivity of R(i)=0,05 A/W and background limited performance (BLIP) detectivity D-BLIP*=6.1x10(9) cm root HZ/W were obtained at V-b=5 V, lambda(p)=8.6 mu m, and T-BLIP=66 K for QWIP-A, while R(i)=0.33 A/W and D-BLIP*=1.63x10(10) cm root Hz/W at V-b=4 V, pi(p)=11.2. mu m, and T-BLIP-50 K were obtained for QWIP-B. (C) 1996 American Institute of Physics. C1 USA,RES LAB,AMSRL,PS,DE,FT MONMOUTH,NJ 07703. LOCKHEED MARTIN ELECT LAB,SYRACUSE,NY 13221. NATL CHIAO TUNG UNIV,DEPT ELECT ENGN,HSINCHU,TAIWAN. RP Chiang, JC (reprint author), UNIV FLORIDA,DEPT ELECT & COMP ENGN,GAINESVILLE,FL 32611, USA. NR 17 TC 54 Z9 54 U1 0 U2 4 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 14 PY 1996 VL 69 IS 16 BP 2412 EP 2414 DI 10.1063/1.117654 PG 3 WC Physics, Applied SC Physics GA VM317 UT WOS:A1996VM31700036 ER PT J AU Avery, MA Mehrotra, S Johnson, TL Bonk, JD Vroman, JA Miller, R AF Avery, MA Mehrotra, S Johnson, TL Bonk, JD Vroman, JA Miller, R TI Structure-activity relationships of the antimalarial agent artemisinin .5. Analogs of 10-deoxoartemisinin substituted at C-3 and C-9 SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID QINGHAOSU ARTEMISININ; INVITRO; ERYTHROCYTES; DERIVATIVES; CHEMISTRY; MECHANISM; CARBON; DRUG AB Novel 3- and 9-substituted analogs (4-19) of 10-deoxoartemisinin, 3, were prepared from the corresponding known lactones by one-pot reduction with sodium borohydride and boron trifluoride etherate. Reproducibility problems associated with this heterogeneous reaction were encountered on small reaction scales, and thus alternative methodology was sought for this reduction. Conversion of the lactones to tetrahydropyrans via the corresponding intermediate lactols was made more reproducible using a two-step sequence involving low-temperature reduction with diisobutylaluminum hydride followed by deoxygenation with boron trifluoride etherate in the presence of triethylsilane. In this manner, 10-deoxoartemisinin (3) could be obtained from artemisinin (1) in greater than 95% overall yield. All analogs were tested in vitro against W-2 and D-6 strains of Plasmodium falciparum. Several of the analogs were much more active than the natural product (+)-artemisinin (1) or 10-deoxoartemisinin (3). Conventional structure-activity relationships are discussed in relation to the bioassay data. C1 UNIV MISSISSIPPI,SCH PHARM,PHARMACEUT SCI RES INST,UNIVERSITY,MS 38677. WALTER REED ARMY INST RES,DIV EXPT THERAPEUT,WASHINGTON,DC 20307. RP Avery, MA (reprint author), UNIV MISSISSIPPI,SCH PHARM,DEPT MED CHEM,UNIVERSITY,MS 38677, USA. NR 29 TC 66 Z9 67 U1 0 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD OCT 11 PY 1996 VL 39 IS 21 BP 4149 EP 4155 DI 10.1021/jm9603577 PG 7 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA VM048 UT WOS:A1996VM04800004 PM 8863791 ER PT J AU Venkatesan, MM Alexander, WA FernandezPrada, C AF Venkatesan, MM Alexander, WA FernandezPrada, C TI A Shigella flexneri invasion plasmid gene, ipgH, with homology to IS629 and sequences encoding bacterial sugar phosphate transport proteins SO GENE LA English DT Article DE recombinant DNA; enteric bacteria; ipaH flanking sequences ID NUCLEOTIDE-SEQUENCE; ESCHERICHIA-COLI; PRODUCTS; SYSTEM AB Sequences representing the 2684 bp flanking the ipaH(4.5) gene on the invasion plasmid of Shigella flexneri 5 indicate an unusual fusion gene, designated ipgH, in which the first 27 amino acids (aa) are identical to ORF2 of IS629. The aa sequence encoded by the remainder of ipgH bears significant homology to Escherichia coli and to Salmonella typhimurium GlpT and UhpT proteins and to the S. typhimurium PgtP protein, which are involved in the uptake of high-energy sugar phosphates from an external source. C1 GEORGE WASHINGTON UNIV, WASHINGTON, DC 20037 USA. RP Venkatesan, MM (reprint author), WALTER REED ARMY INST RES, DEPT ENTER INFECT, DIV COMMUNICABLE DIS & IMMUNOL, BLDG 40, RM B020, WASHINGTON, DC 20307 USA. NR 17 TC 5 Z9 5 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-1119 EI 1879-0038 J9 GENE JI Gene PD OCT 10 PY 1996 VL 175 IS 1-2 BP 23 EP 27 DI 10.1016/0378-1119(96)00115-1 PG 5 WC Genetics & Heredity SC Genetics & Heredity GA VR398 UT WOS:A1996VR39800004 PM 8917071 ER PT J AU Folkes, PA Smith, D Lux, RA Zhou, W Thompson, R Moerkirk, R Cooke, P Brown, K AF Folkes, PA Smith, D Lux, RA Zhou, W Thompson, R Moerkirk, R Cooke, P Brown, K TI Back-gating effect of low-temperature GaAs on a pseudomorphic modulation-doped field-effect transistor SO APPLIED PHYSICS LETTERS LA English DT Article ID QUANTUM-WELL STRUCTURES; MOLECULAR-BEAM EPITAXY; ELECTRON-GAS; BUFFER; PHOTOLUMINESCENCE; ABSORPTION; BAND AB Low-temperature (LT) photoluminescence (PL) measurements on pseudomorphic modulation-doped transistors with a (LT) GaAs layer in the GaAs substrate have revealed the existence of a substrate voltage. The substrate voltage is manifested by a decrease in the PL transition energies of the quantum-well subbands due to the quantum confined Stark effect. Our results indicate that the substrate voltage is generated by the trapping of holes from the undoped molecular-beam-epitaxy-grown GaAs at the GaAs/LT GaAs interface by the high concentration of arsenic antisite defects in the LT GaAs layer. (C) 1996 American Institute of Physics. C1 GEOCENTERS INC,EATONTOWN,NJ 07724. KEAN COLL NEW JERSEY,UNION,NJ 07083. RP Folkes, PA (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 21 TC 2 Z9 2 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 7 PY 1996 VL 69 IS 15 BP 2234 EP 2236 DI 10.1063/1.117138 PG 3 WC Physics, Applied SC Physics GA VL184 UT WOS:A1996VL18400029 ER PT J AU Wolden, CA Sitar, Z Davis, RF Prater, JT AF Wolden, CA Sitar, Z Davis, RF Prater, JT TI Textured diamond growth by low pressure flat flame chemical vapor deposition SO APPLIED PHYSICS LETTERS LA English DT Article ID COMBUSTION-FLAME; FILMS; SILICON AB A laminar, flat-flame burner has been constructed for the deposition of diamond films using an acetylene/oxygen flame at reduced pressures. The stagnation flow results in uniform deposition conditions across the diameter of the burner. Under certain operating conditions the growth rate and morphology are primarily controlled by the substrate temperature. Conditions for the deposition of [100] textured films are reported for a flat-flame system. From growth rate measurements an apparent activation energy of 22 kcal/mol was observed. The maximum growth rate of 5.5 mu m/h is the highest reported to date for a low pressure combustion system. (C) 1996 American Institute of Physics. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP Wolden, CA (reprint author), N CAROLINA STATE UNIV,DEPT MAT SCI & ENGN,BOX 7907,RALEIGH,NC 27695, USA. RI Davis, Robert/A-9376-2011 OI Davis, Robert/0000-0002-4437-0885 NR 19 TC 19 Z9 20 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 7 PY 1996 VL 69 IS 15 BP 2258 EP 2260 DI 10.1063/1.117146 PG 3 WC Physics, Applied SC Physics GA VL184 UT WOS:A1996VL18400037 ER PT J AU Chambers, CC Hawkins, GD Cramer, CJ Truhlar, DG AF Chambers, CC Hawkins, GD Cramer, CJ Truhlar, DG TI Model for aqueous solvation based on class IV atomic charges and first solvation shell effects SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID CHEMICAL CONFORMATIONAL-ANALYSIS; FREE-ENERGIES; SEMIEMPIRICAL CALCULATIONS; ELECTROSTATIC POTENTIALS; MOLECULAR MECHANICS; NEUTRAL MOLECULES; SURFACE-AREA; RING-SYSTEMS; GAS-PHASE; WATER AB We present a new set of geometry-based functional forms for parametrizing effective Coulomb radii and atomic surface tensions of organic solutes in water. In particular, the radii and surface tensions depend in some cases on distances to nearby atoms. Combining the surface tensions with electrostatic effects included in a Fock operator by the generalized Born model enables one to calculate free energies of solvation, and experimental free energies of solvation are used to parametrize the theory for water. Atomic charges are obtained by both the AM1-CM1A and PM3-CM1P class IV charge models, which yield similar results, and hence the same radii and surface: tensions are used with both charge models, We considered 215 neutral solutes containing H, C, N, O, F, S, Cl, Br, and I and encompassing a very wide variety of organic functional groups, and we obtained a mean unsigned error in the free energy of hydration of 0.50 kcal/mol using CM1A charges and 0.44 kcal/mol using CM1P charges. The predicted solvation energies for 12 cationic and 22 anionic solutes have mean unsigned deviations from experiment of 4.4 and 4.3 kcal/mol for models based on AM1 and PM3, respectively. C1 UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. RP Chambers, CC (reprint author), UNIV MINNESOTA,INST SUPERCOMP,DEPT CHEM,207 PLESANT ST SE,MINNEAPOLIS,MN 55455, USA. RI Truhlar, Donald/G-7076-2015; Cramer, Christopher/B-6179-2011 OI Truhlar, Donald/0000-0002-7742-7294; Cramer, Christopher/0000-0001-5048-1859 NR 82 TC 348 Z9 348 U1 1 U2 21 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD OCT 3 PY 1996 VL 100 IS 40 BP 16385 EP 16398 DI 10.1021/jp9610776 PG 14 WC Chemistry, Physical SC Chemistry GA VK731 UT WOS:A1996VK73100053 ER PT J AU Jonas, WB Medvedev, OS Ruud, C AF Jonas, WB Medvedev, OS Ruud, C TI New possibilities emerging in Russian medical education SO ACADEMIC MEDICINE LA English DT Letter C1 MOSCOW MV LOMONOSOV STATE UNIV,FAC BASIC MED,MOSCOW,RUSSIA. RP Jonas, WB (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV MED,WASHINGTON,DC 20307, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU HANLEY & BELFUS INC PI PHILADELPHIA PA 210 S 13TH ST, PHILADELPHIA, PA 19107 SN 1040-2446 J9 ACAD MED JI Acad. Med. PD OCT PY 1996 VL 71 IS 10 BP 1025 EP 1026 DI 10.1097/00001888-199610000-00003 PG 2 WC Education, Scientific Disciplines; Health Care Sciences & Services SC Education & Educational Research; Health Care Sciences & Services GA VN426 UT WOS:A1996VN42600004 PM 9177630 ER PT J AU Schneider, JJ AF Schneider, JJ TI War, chaos, and history - Beaumont,R SO AMERICAN HISTORICAL REVIEW LA English DT Book Review RP Schneider, JJ (reprint author), USA,COMMAND & GEN STAFF COLL,SCH ADV MIL STUDIES,WASHINGTON,DC, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER HISTORICAL REVIEW PI WASHINGTON PA 400 A ST SE, WASHINGTON, DC 20003 SN 0002-8762 J9 AM HIST REV JI Am. Hist. Rev. PD OCT PY 1996 VL 101 IS 4 BP 1185 EP 1186 DI 10.2307/2169667 PG 2 WC History SC History GA VP497 UT WOS:A1996VP49700022 ER PT J AU Chaknis, MJ Brooks, SE Mitchell, KT Marcus, DM AF Chaknis, MJ Brooks, SE Mitchell, KT Marcus, DM TI Inflammatory opacities of the vitreous in rifabutin-associated uveitis SO AMERICAN JOURNAL OF OPHTHALMOLOGY LA English DT Article ID PROPHYLAXIS; INFECTION AB PURPOSE: To describe rifabutin-associated uveitis with opacities in the inferior and posterior vitreous in three patients with acquired immunodeficiency syndrome. METHOD: Case reports of the three patients are presented. RESULTS: The patients, who were being treated with rifabutin and fluconazole, developed anterior and posterior uveitis. The posterior uveitis was characterized by white yellow inflammatory opacities located in the inferior and posterior vitreous. Discontinuation of rifabutin and the start of topical corticosteroid therapy resulted in improvement of the uveitis and visual acuity. CONCLUSION: Recognition of rifabutin-associated uveitis with opacities in the inferior and posterior vitreous may prevent unnecessary invasive diagnostic and therapeutic procedures. C1 MED COLL GEORGIA,DEPT OPHTHALMOL,AUGUSTA,GA 30912. DWIGHT D EISENHOWER MED CTR,OPHTHALMOL SERV,FT GORDON,GA. NR 5 TC 11 Z9 12 U1 0 U2 0 PU OPHTHALMIC PUBL CO PI CHICAGO PA 77 WEST WACKER DR, STE 660, CHICAGO, IL 60601 SN 0002-9394 J9 AM J OPHTHALMOL JI Am. J. Ophthalmol. PD OCT PY 1996 VL 122 IS 4 BP 580 EP 582 PG 3 WC Ophthalmology SC Ophthalmology GA VK702 UT WOS:A1996VK70200020 PM 8862060 ER PT J AU McAdams, HP Gordon, DS White, CS AF McAdams, HP Gordon, DS White, CS TI Apical lung hernia: Radiologic findings in six cases SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article AB OBJECTIVE. We performed this study to characterize the clinical and radiologic manifestations of apical lung hernias. CONCLUSION. Apical lung hernias typically manifest as unilateral, right-sided air radiolucencies at the thoracic inlet on chest radiographs. They are frequently intermittent and can cause lateral tracheal deviation. Radiologic studies performed at midinspiration may not show hernias. Airway fluoroscopy or CT performed at maximal inspiration may be necessary to confirm the diagnosis. C1 WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20306. UNIV MARYLAND,MED SYST,DEPT DIAGNOST RADIOL,BALTIMORE,MD 21201. RP McAdams, HP (reprint author), DUKE UNIV,MED CTR,DEPT RADIOL,BOX 3808,DURHAM 27710,ENGLAND. RI McAdams, Holman/N-8218-2015 OI McAdams, Holman/0000-0002-7044-3320 NR 12 TC 18 Z9 20 U1 0 U2 1 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD OCT PY 1996 VL 167 IS 4 BP 927 EP 930 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA VJ684 UT WOS:A1996VJ68400023 PM 8819385 ER PT J AU Smith, CD Brown, AE Nakazawa, S Fujioka, H Aikawa, M AF Smith, CD Brown, AE Nakazawa, S Fujioka, H Aikawa, M TI Multi-organ erythrocyte sequestration and ligand expression in rhesus monkeys infected with Plasmodium coatneyi malaria SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID HUMAN CEREBRAL MALARIA; NONHUMAN PRIMATE MODEL; PARASITIZED ERYTHROCYTES; FALCIPARUM-MALARIA; ADHESION MOLECULE-1; CYTOADHERENCE; RECEPTORS AB The pathogenesis of human cerebral malaria is suspected to be caused by blockage of cerebral microvessels by the sequestration of parasitized human red blood cells (PRBC). Examination of infected tissues indicate PRBC sequestration in microvessels is the result of PRBC knob attachment to endothelial cell surface cytoadherence receptors such as CD36, thrombospondin (TSP), and intercellular adhesion molecule-1 (ICAM-1). In lieu of fresh human tissue, several animal models for human cerebral malaria have been developed, the Plasmodium coatneyi-infected rhesus monkey model being the most versatile. To further the understanding of noncerebral malarial complications during disease, we examined noncerebral tissues of infected rhesus monkeys. Our study demonstrated similar microvessel PRBC sequestration and the presence of cytoadherence ligands in noncerebral tissues. Immunohistochemical analysis showed CD36, TSP, and ICAM-1 cytoadherence proteins in several major organs. C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. CASE WESTERN RESERVE UNIV,INST PATHOL,CLEVELAND,OH 44106. TOKAI UNIV,INST MED SCI,TOKAI,IBARAKI,JAPAN. RP Smith, CD (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. FU NIAID NIH HHS [AI-35827] NR 23 TC 21 Z9 21 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1996 VL 55 IS 4 BP 379 EP 383 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA VR968 UT WOS:A1996VR96800007 PM 8916792 ER PT J AU Osorio, JE Schoepp, RJ Yuill, TM AF Osorio, JE Schoepp, RJ Yuill, TM TI Effects of La Crosse virus infection on pregnant domestic rabbits and Mongolian gerbils SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID AEDES-TRISERIATUS; AKABANE VIRUS; CONGENITAL-ABNORMALITIES; LACROSSE VIRUS; TRANSMISSION; INOCULATION; CHIPMUNKS AB The transplacental transmission of La Crosse virus (LACV) was evaluated in domestic rabbits (Oryctolagus cuniculus) and Mongolian gerbils (Meriones unguiculatis) as a potential mechanism for the maintenance of the virus. Rabbits were infected with LACV at different times of gestation by injection of viral suspensions or by exposure to LACV transovarially (TO) infected Aedes triseriatus. Pregnant gerbils were exposed between 16-24 days of gestation to LACV TO- infected Ae. triseriatus. Our results indicate that LACV can infect gerbils in utero. The LACV was isolated from the brain of suckling gerbils that died 3-5 days after birth from LACV-esposed mothers, representing the first evidence of LACV transplacental transmission. Microgliosis was found histologically in the cerebral cortex. In addition, LACV infection of both pregnant gerbils and rabbits resulted in in utero and neonatal mortality. La Crosse virus was not detected in surviving young of infected rabbits even after immunosuppression by administration of cyclophosphamide. Thus, there was no evidence of persistent infection of rabbits following in utero exposure. Surprisingly, some of the infected pregnant gerbils developed progressive paralysis 9-14-days postexposure, and LACV was isolated from the brains of these animals. Histopathologic studies of these tissue samples showed acute meningoencephalitis. The effects of natural LACV infection should be studied in pregnant amplifying hosts, such as chipmunks and squirrels, and in pregnant women. C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. UNIV WISCONSIN,INST ENVIRONM STUDIES,MADISON,WI 53706. UNIV WISCONSIN,SCH VET MED,MADISON,WI 53706. RP Osorio, JE (reprint author), UNIV WISCONSIN,DEPT ANIM HLTH & BIOMED SCI,MADISON,WI 53706, USA. FU NIAID NIH HHS [AI-00771] NR 40 TC 6 Z9 7 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1996 VL 55 IS 4 BP 384 EP 390 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA VR968 UT WOS:A1996VR96800008 PM 8916793 ER PT J AU Vaughan, JA Turell, MJ AF Vaughan, JA Turell, MJ TI Facilitation of Rift Valley fever virus transmission by Plasmodium berghei sporozoites in Anopheles stephensi mosquitoes SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID INCREASED DISSEMINATION; VECTOR COMPETENCE; MICROFILARIAE; INGESTION; CULICIDAE; DIPTERA AB Certain mosquito species are susceptible to viral infection but cannot transmit the virus due to a salivary gland barrier. We hypothesized that such species could transmit virus if the mosquito were infected with both virus and malaria parasites. Malaria sporozoites disrupt the integrity of mosquito salivary glands and, in so doing, map destroy salivary gland barriers to viral transmission. To examine this postulate, the model system of Rift Valley fever (RVF) virus and a rodent parasite, Plasmodium berghei, in Anopheles stephensi mosquitoes was used. Viral trans mission rates for RVF virus-inoculated anophelines that were previously fed either gametocytemic blood (malaria-infected) or normal blood (control) were compared. Viral transmission rates for anophelines having concurrent sporozoite infection of the salivary glands were 32% (n = 25). None of the RVF virus-inoculated control anophelines (n = 55) transmitted virus. These studies confirm an earlier report that malaria sporozoites can disrupt salivary gland barriers and enhance mosquito transmission of arboviruses. Taken together with similar studies using microfilarial parasites, it is increasingly apparent that mosquito-borne parasites have the potential to enhance mosquito transmission of arboviruses. C1 USA,MED RES INST INFECT DIS,DIAGNOST SYST DIV,VESTOR ASSESSMENT BRANCH,FREDERICK,MD 21702. NR 16 TC 19 Z9 20 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1996 VL 55 IS 4 BP 407 EP 409 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA VR968 UT WOS:A1996VR96800012 PM 8916797 ER PT J AU Schwartz, BS Sanchez, JL Sanders, ML DeFraites, RF AF Schwartz, BS Sanchez, JL Sanders, ML DeFraites, RF TI Tick avoidance behaviors associated with a decreased risk of anti-tick salivary gland protein antibody seropositivity in military personnel exposed to Amblyomma americanum in Arkansas SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID LONE STAR TICK; JERSEY OUTDOOR WORKERS; BORRELIA-BURGDORFERI; PRESSURIZED SPRAYS; BORNE INFECTIONS; IXODES-DAMMINI; LYME-DISEASE; PERMETHRIN; PROTECTION; ACARI AB During April through September 1990, 399 military personnel who originated from either Fort Chaffee, Arkansas (n = 236) or Fort Wainwright, Alaska (n = 163) were studied during maneuvers in tick-infested areas at Fort Chaffee. Study subjects completed a questionnaire and had pre- and post-maneuvers serum specimens analyzed for antibodies to several rickettsial and ehrlichial agents and to Amblyomma americanum (lone star tick) salivary gland proteins (anti-tick saliva antibodies [ATSA], a biologic marker of tick exposure), Military rank/grade and home station were associated with pre-maneuvers ATSA seropositivity by enzyme-linked immunosorbent assay (ELISA). Fort Wainwright personnel were more likely to show at least a 50% increase in ATSA levels, compared with subjects from Fort Chaffee, from the pre- to the post maneuvers specimen (adjusted odds ratio [AOR] = 2.7, 95% confidence interval [CI] = 1.2-6.1). Subjects from Fort Wainwright who did not report use of bed netting were at an increased risk of post-maneuvers ATSA seropositivity (AOR = 4.1, 95% CI = 1.5-11.5). In contrast, subjects from Fort Chaffee who did not report tucking pants into socks were at increased risk of post-maneuvers ATSB seropositivity (AOR = 2.8, 95% CI = 1.1-7.1). Subjects from Fort Chaffee who reported an attached tick bite during maneuvers were more likely to be ATSA-seropositive in the post-maneuvers specimen (AOR = 2.5, 95% CI = 1.2-5.2). Western blot assays revealed large differences in tick salivary gland proteins that were recognized on the post-maneuvers specimen among three randomly selected individuals, and small differences within a single individual who reported a tick bite during maneuvers, comparing pre- and post-maneuvers specimens. The ATSA ELISA seropositivity was not associated with seroconversion to the tick-borne infectious agents. C1 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT MOL MICROBIOL & IMMUNOL,BALTIMORE,MD 21205. WALTER REED ARMY MED CTR,DIV PREVENT MED,WASHINGTON,DC 20307. USA,MED RES UNIT BRAZIL,RIO JANEIRO,BRAZIL. RP Schwartz, BS (reprint author), JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DIV OCCUPAT HLTH,DEPT ENVIRONM HLTH SCI,615 N WOLFE ST,BALTIMORE,MD 21205, USA. FU NIAID NIH HHS [R29 AI-31608] NR 25 TC 10 Z9 10 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1996 VL 55 IS 4 BP 410 EP 416 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA VR968 UT WOS:A1996VR96800013 PM 8916798 ER PT J AU Orndorff, GR Sadjimin, T Simanjuntak, CH OHanley, P Punjabi, NH Tjokrosonto, S Corwin, A Dibley, M Lebron, CI Echeverria, P AF Orndorff, GR Sadjimin, T Simanjuntak, CH OHanley, P Punjabi, NH Tjokrosonto, S Corwin, A Dibley, M Lebron, CI Echeverria, P TI Enterotoxigenic Escherichia coli diarrhea in children less than five years of age in central Java SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article AB A community-based prospective study was performed from December 1993 through March 31, 1994 in Indonesia in children less than five years of age. Enterotoxigenic Escherichia coli (ETEC) was identified in diarrheic stool by colony hybridization assay, using toxin probes, and this bacterium was isolated from 19% of 340 episodes of diarrhea. Sixty-one percent of ETEC produced heat-labile toxin (LT) only, 325 LT and heat-stable toxin (ST), and 75 ST only. The age-specific incidence rates of diarrhea among children 0-1 and 2-3 years of age were 77% and 61%, respectively, during the study period; ETEC was isolated from 26% of children 0-1 years of age versus 53% for children 2-3 years of age. As many as seven episodes of diarrhea were repeatedly experienced by a single child during the four-month study period; however, only two children had more than one episode of known ETEC-associated diarrheal disease during the period of observation. C1 GADJAH MADA UNIV,CLIN EPIDEMIOL & BIOSTAT UNIT,YOGYAKARTA,INDONESIA. NATL INST HLTH RES & DEV,JAKARTA,INDONESIA. STANFORD UNIV,SCH MED,DEPT MED,STANFORD,CA 94305. STANFORD UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,STANFORD,CA 94305. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT INT HLTH,BALTIMORE,MD 21205. ARMED FORCES RES INST MED SCI,BANGKOK 10400,THAILAND. VET AFFAIRS MED CTR,PALO ALTO,CA 94304. RP Orndorff, GR (reprint author), USN,MED RES UNIT 2,JAKARTA,INDONESIA. NR 7 TC 10 Z9 10 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1996 VL 55 IS 4 BP 449 EP 451 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA VR968 UT WOS:A1996VR96800021 PM 8916806 ER PT J AU Chamberlin, J Bryan, JP Jones, DL Reyes, L Hakre, S AF Chamberlin, J Bryan, JP Jones, DL Reyes, L Hakre, S TI Seroprevalence of hepatitis B virus among school-age children in the Stann Creek district of Belize, Central America SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID LATIN-AMERICA; INFECTION AB Adults in the Stann Creek District of Belize have a high prevalence of hepatitis B virus (HBV) infection, but the age of onset of these infections is unclear. We conducted a seroprevalence study of hepatitis B markers among Stann Creek school-age children to provide information for planning a hepatitis B vaccine program. The overall prevalence in 587 students was high for antibody to hepatitis B core antigen (anti-HBc) (43.3%) and hepatitis B surface antigen (HBsAg) (7.7%). There was marked Variation of anti-HBc by school and by the predominant ethnic groups attending these schools. Maya had the highest prevalence (76%), followed by Mestizo (50%), Garifuna (37%), and Creole (25%). Children less than nine years of age attending the rural primary schools (mostly Mayan and Mestizo) had significantly higher prevalence of anti-HBc than did children attending the urban primary school (mostly Garifuna and Creole) (P < 0.05). Anti-HBc was found in 42% and 36% of students at the two high schools. Of the five schools tested, only at the urban primary school did anti-HBc positivity increase with age. Based on an analysis of the cost of serologic screening before immunization compared with mass vaccination, preimmunization serologic screening resulted in vaccine program cost savings in four of the five schools. Because most children in the rural areas contract hepatitis B before entering school, immunization against HBV should be integrated into the routine infant immunization program. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. MINIST HLTH,EPIDEMIOL RES CTR,BELIZE CITY,BELIZE. RP Chamberlin, J (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT PREVENT MED & BIOMETR,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 17 TC 6 Z9 7 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1996 VL 55 IS 4 BP 452 EP 455 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA VR968 UT WOS:A1996VR96800022 PM 8916807 ER PT J AU Shorr, AF Kester, KE AF Shorr, AF Kester, KE TI Meningitis and hepatitis complicating intravenous immunoglobulin therapy SO ANNALS OF PHARMACOTHERAPY LA English DT Article ID ASEPTIC-MENINGITIS AB OBJECTIVE: TO report a case of concomitant meningitis and hepatitis complicating the use of intravenous immune globulin (IVIG). CASE SUMMARY: A 39-year-old African-American woman with an autoimmune syndrome developed both acute meningitis and hepatitis following administration of IVIG. These resolved over several days and left no sequellae. DISCUSSION: This represents the first case of concomitant acute meningitis and hepatitis associated with IVIG. Thorough microbiologic and serologic evaluation of the patient failed to demonstrate an infectious etiology. We postulate that our patient's syndrome resulted from direct toxicity of IVIG. CONCLUSIONS: Both acute meningitis and hepatitis may simultaneously complicate IVIG therapy. The specific mechanism remains unclear. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP Shorr, AF (reprint author), WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307, USA. RI Kester, Kent/A-2114-2011 OI Kester, Kent/0000-0002-5056-0802 NR 6 TC 5 Z9 5 U1 0 U2 0 PU HARVEY WHITNEY BOOKS CO PI CINCINNATI PA PO BOX 42696, CINCINNATI, OH 45242 SN 1060-0280 J9 ANN PHARMACOTHER JI Ann. Pharmacother. PD OCT PY 1996 VL 30 IS 10 BP 1115 EP 1116 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA VL133 UT WOS:A1996VL13300010 PM 8893119 ER PT J AU Kinnamon, KE Poon, BT Hanson, WL Waits, VB AF Kinnamon, KE Poon, BT Hanson, WL Waits, VB TI Primaquine analogues that are potent anti-Trypanosoma cruzi agents in a mouse model SO ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY LA English DT Article ID CHEMOTHERAPY AB Seventy-seven primaquine analogues were evaluated for their effectiveness in reducing the parasitaemias in female albino mice (aged 4-6 weeks) which had been infected with a Brazilian strain of Trypanosoma cruzi 15 days earlier. Of the analogues tested, 23 were more effective than the reference drug, nifurtimox, and one was >14-fold as effective as the standard and almost four times as active as primaquine itself. Certain members of the series tested warrant further evaluation. C1 WALTER REED ARMY INST RES,DIV EXPT THERAPEUT,WASHINGTON,DC 20307. UNIV GEORGIA,COLL VET MED,DEPT PARASITOL,ATHENS,GA 30602. NR 14 TC 12 Z9 12 U1 0 U2 0 PU W B SAUNDERS CO LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0003-4983 J9 ANN TROP MED PARASIT JI Ann. Trop. Med. Parasitol. PD OCT PY 1996 VL 90 IS 5 BP 467 EP 474 PG 8 WC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine SC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine GA VK616 UT WOS:A1996VK61600002 PM 8915122 ER PT J AU Meiselman, HL AF Meiselman, HL TI Food preferences and chemical senses: Comments on the Food Attitude Survey of Frank and van der Klaauw SO APPETITE LA English DT Editorial Material RP Meiselman, HL (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 10 TC 1 Z9 1 U1 0 U2 1 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0195-6663 J9 APPETITE JI Appetite PD OCT PY 1996 VL 27 IS 2 BP 193 EP 195 PG 3 WC Behavioral Sciences; Nutrition & Dietetics SC Behavioral Sciences; Nutrition & Dietetics GA VT217 UT WOS:A1996VT21700008 PM 8937622 ER PT J AU Simeonsson, JB Sausa, RC AF Simeonsson, JB Sausa, RC TI Trace analysis of NO2 in the presence of NO by laser photofragmentation fragment photoionization spectrometry at visible wavelengths SO APPLIED SPECTROSCOPY LA English DT Article DE laser photofragmentation fragment photoionization spectrometry; NO/NO2 detection and discrimination; spectroscopic techniques; trace NOx analysis; visible laser radiation ID MULTI-PHOTON IONIZATION; ENHANCED MULTIPHOTON IONIZATION; PHOTOELECTRON-SPECTROSCOPY; NITRIC-OXIDE; DISTRIBUTIONS; MOLECULES; 2-PHOTON; SPECTRA; DYNAMICS; FLAME AB Trace concentrations of NO and NO2 molecules are differentiated spectrally by using a visible dye laser and a simple flow cell with a pair of miniature electrodes for ion detection. NO is detected near 452 mm by (2+2) resonance-enhanced multiphoton ionization via its A(2) Sigma(+)-X(2)II (0,0) transitions, while NO2 is detected by laser photofragmentation with subsequent fragment NO ionization via the A(2) Sigma(+)-X(2)II (0,0) and (1,1) transitions. Spectral differentiation is possible since the internal energy of the NO photofragment differs from that of ''ambient'' NO. Measurement of vibrationally excited NO via its A(2) Sigma(+)-X(2)II (0,3) band is also demonstrated at 517 mn. Rotationally resolved spectra of NO and fragment NO are analysed by using a multiparameter computer program based on two-photon energy level expressions and line strengths for A(2) Sigma(+)-X(2)II transitions. Boltzmann analysis of the P-12 + O-22 branch of the (0,0) band reveals that the rotational temperature of fragment NO is approximately 500 K compared to room-temperature NO. Limits of detection [signal-to-noise (S\N) = 3] of NO and NO2 are in the 20-40-ppbv range at 449.2, 450.7, and 452.6 mn for a 10-s integration time. The limit of detection of NO2 at 517.5 mn is 75 ppbv. The analytical utility of the technique for ambient air analysis is evaluated and discussed. C1 USA,RES LAB,AMSRL,WT,PC,ABERDEEN PROVING GROUND,MD 21005. UNIV IOWA,DEPT CHEM,IOWA CITY,IA 52242. NR 24 TC 11 Z9 11 U1 2 U2 4 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA PO BOX 1438, FREDERICK, MD 21701 SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD OCT PY 1996 VL 50 IS 10 BP 1277 EP 1282 DI 10.1366/0003702963904926 PG 6 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA VR816 UT WOS:A1996VR81600011 ER PT J AU Field, PE Combs, RJ Knapp, RB AF Field, PE Combs, RJ Knapp, RB TI Equilibrium vapor cell for quantitative IR absorbance measurements SO APPLIED SPECTROSCOPY LA English DT Article DE infrared absorbance; equilibrium vapor cell; quantitative infrared analysis; FT-IR spectrometry ID TRANSFORM INFRARED SPECTROMETRY; AUTOMATED DETECTION; INTERFEROGRAMS AB Infrared absorbance measurements through a gas Bow cell are made with the closed-loop circulation of vapor/air mixtures equilibrated with the use of temperature-regulated aqueous solutions. Constant reproducible vapor pressures of organic solutes are established with the equilibrated aqueous solutions. The water solvent depresses the vapor pressure of the pure organic solutes of methanol, ethanol, isopropanol, acetone, and methyl ethyl ketone (MEK). knowledge of the solution liquid mole fractions, the pure component vapor pressures, and the Wilson coefficients permits determination of the solute vapor pressures to within 2% accuracy. Reliable aqueous solution preparation requires only the correct weighings of pure constituent materials before mixing to achieve the targeted solute liquid mole fractions. Absorbances are measured for four of the five solutes over a range of seven concentrations and for MEK over four concentrations. These concentrations show the absorbance region of adherence to Beer's law with an experimental precision of approximately +/-2% for the solutes studied. Absorptivities that are calculated from the Beer's law slope are compared to the available infrared absorbance data. C1 USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. VIRGINIA POLYTECH INST & STATE UNIV,DEPT CHEM,BLACKSBURG,VA 24061. NR 18 TC 21 Z9 21 U1 0 U2 4 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA PO BOX 1438, FREDERICK, MD 21701 SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD OCT PY 1996 VL 50 IS 10 BP 1307 EP 1313 DI 10.1366/0003702963904935 PG 7 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA VR816 UT WOS:A1996VR81600016 ER PT J AU Young, PC Krivda, SJ Benson, PM Sau, P AF Young, PC Krivda, SJ Benson, PM Sau, P TI Purpuric eruption with bloody diarrhea in an adult SO ARCHIVES OF DERMATOLOGY LA English DT Article ID HENOCH-SCHONLEIN PURPURA RP Young, PC (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD OCT PY 1996 VL 132 IS 10 BP 1241 EP & DI 10.1001/archderm.132.10.1241 PG 2 WC Dermatology SC Dermatology GA VM039 UT WOS:A1996VM03900021 PM 8929094 ER PT J AU Roach, JM Muza, SR Rock, PB Lyons, TP Lilly, CM Drazen, JM Cymerman, A AF Roach, JM Muza, SR Rock, PB Lyons, TP Lilly, CM Drazen, JM Cymerman, A TI Urinary leukotriene E(4) levels increase upon exposure to hypobaric hypoxia SO CHEST LA English DT Article DE altitude; altitude sickness; leukotrienes ID ACUTE MOUNTAIN-SICKNESS; DEXAMETHASONE; ACETAZOLAMIDE; PERMEABILITY; ALTITUDES AB Study objective: To determine whether urinary leukotriene E(4) (uLTE(4)) levels increase upon exposure to high altitude, and also to ascertain the relationship between uLTE(4) levels and symptoms of acute mountain sickness (AMS). Design: Prospective, unblinded, single-factor altitude) experimental study. Settings: US Army research laboratory facilities at sea level ([SL] 50 m), 1,830 m, and 4,300 m. Participants: Eight healthy male subjects ranging in age from 19 to 24 years. Measurements: uLTE(4) levels and symptoms of AMS were measured at just above SL (50 m), 3 1/2 days after being transported from SL to moderate altitude (MA) (1,830 m), and 1 1/2 days after ascent from 1,830 to 4,300 m high altitude [HA]). Symptoms of AMS were assessed using standard indexes derived from he Environmental Symptoms Questionnaire weighted toward cerebral (AMS-C) and respiratory (AMS-R) manifestations. Oxygen saturation was measured noninvasively by pulse oximetry at SL and HA. Results: The mean (+/-SEM) uLTE(4) levels (pg/mg creatinine) were 67.9 (+/-13.2) at SL; 82.3 (+/-5.5) at MA; and 134.8 (+/-19.4) at HA (p<0.05 comparing HA with SL and MA). Conclusions: We conclude that uLTE(4) levels increase shortly after exposure to HA even after staging for 4 days at MA. Although this study does not clearly demonstrate a relationship between uLTE(4) levels and symptoms of AMS, it supports the hypothesis that leukotrienes may be involved in the pathophysiologic state of AMS. C1 USA,ENVIRONM MED RES INST,ALTITUDE PHYSIOL & MED DIV,NATICK,MA 01760. BRIGHAM & WOMENS HOSP,DEPT MED,COMBINED PROGRAM PULM & CRIT CARE MED,BOSTON,MA 02115. HARVARD UNIV,SCH MED,BOSTON,MA. RI Drazen, Jeffrey/E-5841-2012 NR 21 TC 12 Z9 12 U1 0 U2 1 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD OCT PY 1996 VL 110 IS 4 BP 946 EP 951 PG 6 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA VN269 UT WOS:A1996VN26900019 PM 8874250 ER PT J AU Dooley, D Beckius, M Bostic, P AF Dooley, D Beckius, M Bostic, P TI Spook rouse sporotrichosis: A point source outbreak of cutaneous sporotrichosis from hay bale props in a halloween haunted house. SO CLINICAL INFECTIOUS DISEASES LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD OCT PY 1996 VL 23 IS 4 BP 29 EP 29 PG 1 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA VN246 UT WOS:A1996VN24600077 ER PT J AU Nelson, K Vahey, MA Suriyanon, V DeBoer, M Kuntolbutra, S Celentano, D Hoover, D Duerr, A AF Nelson, K Vahey, MA Suriyanon, V DeBoer, M Kuntolbutra, S Celentano, D Hoover, D Duerr, A TI Association of HIV-1 clade E serum viral load and heterosexual transmission. SO CLINICAL INFECTIOUS DISEASES LA English DT Meeting Abstract C1 JOHNS HOPKINS UNIV,BALTIMORE,MD. WALTER REED ARMY INST RES,ROCKVILLE,MD. CHIANG MAI UNIV,CHIANG MAI 50000,THAILAND. CTR DIS CONTROL,ATLANTA,GA 30333. NR 0 TC 0 Z9 0 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD OCT PY 1996 VL 23 IS 4 BP 260 EP 260 PG 1 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA VN246 UT WOS:A1996VN24600306 ER PT J AU Fleckenstein, JM Warren, RL Elsinghorst, EA AF Fleckenstein, JM Warren, RL Elsinghorst, EA TI Interleukin-8 response ol cultured human intestinal epithelial cells to enterotoxigenic Escherichia coli (ETEC). SO CLINICAL INFECTIOUS DISEASES LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. UNIV KANSAS,DEPT MICROBIOL,LAWRENCE,KS 66045. WALTER REED ARMY INST RES,WASHINGTON,DC. NR 0 TC 0 Z9 0 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD OCT PY 1996 VL 23 IS 4 BP 317 EP 317 PG 1 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA VN246 UT WOS:A1996VN24600363 ER PT J AU Kester, KE McEvoy, PL Johnson, SC AF Kester, KE McEvoy, PL Johnson, SC TI Impact of intravenous catheter removal on successful treatment of Corynebacterium jeikeium bacteremia. SO CLINICAL INFECTIOUS DISEASES LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIV COLORADO,HLTH SCI CTR,DENVER,CO. RI Kester, Kent/A-2114-2011 OI Kester, Kent/0000-0002-5056-0802 NR 0 TC 0 Z9 0 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD OCT PY 1996 VL 23 IS 4 BP 328 EP 328 PG 1 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA VN246 UT WOS:A1996VN24600374 ER PT J AU Tezduyar, T Aliabadi, S Behr, M Johnson, A Kalro, V Litke, M AF Tezduyar, T Aliabadi, S Behr, M Johnson, A Kalro, V Litke, M TI Flow simulation and high performance computing SO COMPUTATIONAL MECHANICS LA English DT Article ID FINITE-ELEMENT COMPUTATION; NAVIER-STOKES EQUATIONS; 3-DIMENSIONAL MESH GENERATION; INCOMPRESSIBLE FLOWS; CONNECTION MACHINE; FLUID-DYNAMICS; COMPRESSIBLE FLOWS; MOVING BOUNDARIES; VISCOUS-FLOW; FORMULATION AB Flow simulation is a computational tool for exploring science and technology involving flow applications. It can provide cost-effective alternatives or complements to laboratory experiments, field tests and prototyping. Flow simulation relies heavily on high performance computing (HPC). We view HPC as having two major components. One is advanced algorithms capable of accurately simulating complex, real-world problems. The other is advanced computer hardware and networking with sufficient power, memory and bandwidth to execute those simulations. While HPC enables dow simulation, flow simulation motivates development of novel HPC techniques. This paper focuses on demonstrating that flow simulation has come a long way and is being applied to many complex, real-world problems in different fields of engineering and applied sciences, particularly in aerospace engineering and applied fluid mechanics. Flow simulation has come a long way because HPC has come a long way. This paper also provides a brief review of some of the recently-developed HPC methods and tools that has played a major role in bringing flow simulation where it is today. A number of 3D flow simulations are presented in this paper as examples of the level of computational capability reached with recent HPC methods and hardware. These examples are, flow around a fighter aircraft, flow around two trains passing in a tunnel,large ram-air parachutes, flow over hydraulic structures, contaminant dispersion in a model subway station, airflow past an automobile, multiple spheres falling in a liquid-filled tube, and dynamics of a paratrooper jumping from a cargo aircraft. RP Tezduyar, T (reprint author), UNIV MINNESOTA, ARMY HPC RES CTR, 1100 WASHINGTON AVE S, MINNEAPOLIS, MN 55415 USA. RI Behr, Marek/H-5401-2011; Tezduyar, Tayfun/F-6134-2012 OI Behr, Marek/0000-0003-4257-8276; Tezduyar, Tayfun/0000-0001-8707-3162 NR 83 TC 104 Z9 106 U1 0 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0178-7675 J9 COMPUT MECH JI Comput. Mech. PD OCT PY 1996 VL 18 IS 6 BP 397 EP 412 DI 10.1007/BF00350249 PG 16 WC Mathematics, Interdisciplinary Applications; Mechanics SC Mathematics; Mechanics GA VR389 UT WOS:A1996VR38900001 ER PT J AU Tayor, DN Echeverria, P AF Tayor, DN Echeverria, P TI Enteric infections including travelers' diarrhea SO CURRENT OPINION IN INFECTIOUS DISEASES LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; HEMOLYTIC-UREMIC SYNDROME; ESCHERICHIA-COLI O157-H7; NORWALK VIRUS; CRYPTOSPORIDIUM INFECTION; CAMPYLOBACTER-JEJUNI; EMERGING PATHOGEN; MASSIVE OUTBREAK; HEALTHY-ADULTS; UNITED-STATES AB Diarrheal disease research is focused on new interventions, new and improved vaccines, and new diagnostic methods. Micronutrient intervention using zinc and vitamin A has been very important in its impact on childhood diarrheal disease in developing countries. Vaccines for rotavirus and bacterial pathogens such as enterotoxigenic Escherichia coli, Shigella and Salmonella now seem feasible. New diagnostic methods have been useful in defining new viral causes of diarrhea. C1 WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC. NR 56 TC 0 Z9 0 U1 0 U2 0 PU CURRENT SCIENCE PI PHILADELPHIA PA 400 MARKET STREET,SUITE 750 ATTN:SARAH WHEALEN/SUB MGR, PHILADELPHIA, PA 19106 SN 0951-7375 J9 CURR OPIN INFECT DIS JI Curr. Opin. Infect. Dis. PD OCT PY 1996 VL 9 IS 5 BP 340 EP 345 PG 6 WC Infectious Diseases SC Infectious Diseases GA VL301 UT WOS:A1996VL30100010 ER PT J AU Bundy, ML Conroy, PJ Kennedy, JL AF Bundy, ML Conroy, PJ Kennedy, JL TI Simulated & experimental in-wall temperatures for 120 mm ammunition SO DEFENCE SCIENCE JOURNAL LA English DT Article AB Bore and chamber surface, as well as subsurface, temperature predictions are made for the US Army M256 120 mm chromium-plated cannon firing M865, M829, and DM13 cartridges. The surface temperature predictions are validated by comparison with other numerical modelling results, while the subsurface temperature predictions are compared directly with experimental measurements made by in-wall thermocouples. The surface temperature predictions fall in line with other numerical estimates temperatures at each axial location are within the circumferential and round-to-round variation in the experimental probe temperatures. RP Bundy, ML (reprint author), USA,BALLIST RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 6 TC 1 Z9 1 U1 0 U2 1 PU DEFENCE SCIENTIFIC INFORMATION DOCUMENTATION CENTRE PI DELHI PA METCALFE HOUSE, DELHI 110054, INDIA SN 0011-748X J9 DEFENCE SCI J JI Def. Sci. J. PD OCT PY 1996 VL 46 IS 4 BP 223 EP 232 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA WE778 UT WOS:A1996WE77800004 ER PT J AU Harrington, AC Grande, DJ Sollitto, RB AF Harrington, AC Grande, DJ Sollitto, RB TI The chondrocutaneous helical rim advancement flap of Antia and Buch SO DERMATOLOGIC SURGERY LA English DT Letter RP Harrington, AC (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 1076-0512 J9 DERMATOL SURG JI Dermatol. Surg. PD OCT PY 1996 VL 22 IS 10 BP 892 EP 893 PG 2 WC Dermatology; Surgery SC Dermatology; Surgery GA VV368 UT WOS:A1996VV36800013 PM 9246174 ER PT J AU Lockmann, RF AF Lockmann, RF TI Earth's insights: A survey of ecological ethics from the Mediterranean Basin to the Australian outback - Callicott,JB SO ENVIRONMENTAL HISTORY LA English DT Book Review RP Lockmann, RF (reprint author), USA,ENGN DIST,LOS ANGELES,CA, USA. NR 1 TC 0 Z9 0 U1 1 U2 6 PU ENVIRONMENTAL HISTORY PI DURHAM PA 701 VICKERS AVE, DURHAM, NC 27701-3147 SN 1084-5453 J9 ENVIRON HIST JI Environ. Hist. PD OCT PY 1996 VL 1 IS 4 BP 81 EP 82 DI 10.2307/3985282 PG 2 WC Environmental Studies; History SC Environmental Sciences & Ecology; History GA WE841 UT WOS:A1996WE84100008 ER PT J AU Prahinski, JR McHale, KA Temple, MHT Jackson, JP AF Prahinski, JR McHale, KA Temple, MHT Jackson, JP TI Bridle transfer for paresis of the anterior and lateral compartment musculature SO FOOT & ANKLE INTERNATIONAL LA English DT Article AB In the Riordan (bridle) transfer, the posterior tibialis muscle as motor is routed through the interosseous membrane and anastomosed into a ''bridle'' formed by the distal tibialis anterior and peroneus longus muscles. In theory, the bridle provides inversion/eversion balance even if the transfer effects only tenodesis. However, the procedure has been criticized because its insertion is not into bone. This review analyzes the use of bridle transfer in flaccid paresis involving musculature innervated by the peroneal nerve. Surgery was performed 1 to 3 years after injury for patients with traumatic etiology. Ten patients are reviewed at 61 months' mean follow-up. Eight patients had traumatic peroneal nerve loss. Two had neuromuscular etiology. Evaluation included review of records, telephone interviews, and physical examinations. Data on functional status included walking barefoot, running, need for bracing, return to duty, and patient satisfaction. Physical examination recorded ankle position and motions, gait findings, and results of static electromyograms. All patients were able to walk barefoot, but 6 of 10 had a mild to moderate limp. Five patients returned to running initially; only two were able to keep running. Nine patients were brace-free initially (polio sequela required bracing initially), and four others returned to bracing. Of these, two experienced an acute ''tearing'' and dorsiflexion loss, one sustained a prolonged gradual loss of dorsiflexion, and one sustained a contralateral cerebrovascular accident. Only three of seven patients returned to active duty, and one is on jump status. All patients were satisfied with their initial result. Only two patients had no detectable swing phase problems (both returned to active duty). Five patients had peroneal nerve exploration with repair or neurolysis; two of them sustained complete transections. Postoperative electromyograms showed insignificant, if any, nerve return. The Riordan transfer works well for neuromuscular flaccid paresis and in patients with peroneal nerve injuries with low demands. It may stretch out over time to the point of acute failure in patients with high demands. Concurrent peroneal nerve exploration and repair did not seem to be beneficial in this small study. RP Prahinski, JR (reprint author), DEPT ARMY,WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307, USA. NR 7 TC 27 Z9 27 U1 0 U2 4 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1071-1007 J9 FOOT ANKLE INT JI Foot Ankle Int. PD OCT PY 1996 VL 17 IS 10 BP 615 EP 619 PG 5 WC Orthopedics SC Orthopedics GA VN741 UT WOS:A1996VN74100009 PM 8908487 ER PT J AU Moses, F Shay, SS AF Moses, F Shay, SS TI Biliary stent stripes SO GASTROINTESTINAL ENDOSCOPY LA English DT Letter C1 CLEVELAND CLIN,CLEVELAND,OH 44106. RP Moses, F (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD OCT PY 1996 VL 44 IS 4 BP 510 EP 511 DI 10.1016/S0016-5107(96)70118-9 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA VN676 UT WOS:A1996VN67600037 PM 8905386 ER PT J AU Ryu, H Singh, R Cassels, FJ AF Ryu, H Singh, R Cassels, FJ TI Escherichia coli strain RDEC-1 binds, via AF/R1 fimbriae, to a galactosylceramide in rabbit small intestinal brush borders. SO GLYCOBIOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT GASTROENTEROL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0959-6658 J9 GLYCOBIOLOGY JI Glycobiology PD OCT PY 1996 VL 6 IS 7 BP 401 EP 401 PG 1 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA VT565 UT WOS:A1996VT56500114 ER PT J AU Weiskopf, A Senecal, K Vouros, P Kaplan, D Mello, CM AF Weiskopf, A Senecal, K Vouros, P Kaplan, D Mello, CM TI The carbohydrate composition of a spider silk: Nephila clavipes Dragline. SO GLYCOBIOLOGY LA English DT Meeting Abstract C1 NORTHEASTERN UNIV,BARNETT INST,BOSTON,MA 02115. USA,NATICK RES & DEV CTR,NATICK,MA 01760. TUFTS UNIV,DEPT CHEM ENGN,MEDFORD,MA 02155. RI Senecal, Kris/F-3000-2013 NR 0 TC 5 Z9 5 U1 0 U2 1 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0959-6658 J9 GLYCOBIOLOGY JI Glycobiology PD OCT PY 1996 VL 6 IS 7 BP 1703 EP 1703 PG 1 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA VT565 UT WOS:A1996VT56500228 ER PT J AU Holtzmuller, K Rholl, J Squire, O Sjogren, MH AF Holtzmuller, K Rholl, J Squire, O Sjogren, MH TI Does ethnic background, gender, or alcohol have a role in clinical severity of hepatitis C (HCV)? SO HEPATOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 1996 VL 24 IS 4 SU S BP 1009 EP 1009 PN 2 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA VL285 UT WOS:A1996VL28501008 ER PT J AU Sherman, KE Sjogren, MH Creager, RL Freeman, S Lewey, S Root, S Davis, D Weber, FL Ishak, K Goodman, ZD AF Sherman, KE Sjogren, MH Creager, RL Freeman, S Lewey, S Root, S Davis, D Weber, FL Ishak, K Goodman, ZD TI Thymosin alpha-1 plus interferon combination therapy for chronic hepatitis C: Results of a randomized controlled trial SO HEPATOLOGY LA English DT Meeting Abstract C1 UNIV CINCINNATI,DEPT MED,CINCINNATI,OH 45221. FITZSIMONS ARMY MED CTR,DEPT MED,AURORA,CO 80045. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,DEPT MED,WASHINGTON,DC 20306. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 1996 VL 24 IS 4 SU S BP 1103 EP 1103 PN 2 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA VL285 UT WOS:A1996VL28501101 ER PT J AU PerezJimenez, O Kapur, J Szentendrei, T Bednarek, J Sjogren, MH AF PerezJimenez, O Kapur, J Szentendrei, T Bednarek, J Sjogren, MH TI Hepatitis C virus (HCV) genotype change after treatment with interferon alpha 2B (INF-alpha 2b). SO HEPATOLOGY LA English DT Meeting Abstract C1 ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 1996 VL 24 IS 4 SU S BP 1738 EP 1738 PN 2 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA VL285 UT WOS:A1996VL28501734 ER PT J AU Rhodes, DL AF Rhodes, DL TI A design language for analog circuits SO IEEE SPECTRUM LA English DT Article C1 PRINCETON UNIV,PRINCETON,NJ 08544. RP Rhodes, DL (reprint author), USA,RES LAB,PHYS SCI DIRECTORATE,ELECTROPHYS MODELING BRANCH,WASHINGTON,DC 20310, USA. NR 3 TC 1 Z9 1 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9235 J9 IEEE SPECTRUM JI IEEE Spectr. PD OCT PY 1996 VL 33 IS 10 BP 43 EP 48 DI 10.1109/6.540089 PG 6 WC Engineering, Electrical & Electronic SC Engineering GA VK161 UT WOS:A1996VK16100012 ER PT J AU Lee, CS Nalbandian, V Schwering, F AF Lee, CS Nalbandian, V Schwering, F TI Circularly polarized microstrip antenna with a single feed SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Letter AB A novel circularly polarized (CP) microstrip antenna with a single coaxial feed is introduced. The antenna consists of two layers, each radiating fields which at the zenith are perpendicular to each other with 90 degrees phase difference. The CP bandwidth is substantially higher than that of the previously reported CP microstrip antennas with two nearly degenerate modes. In principle, a perfect CP radiation is feasible without the input impedance mismatch. The CP design procedure is independent of the feed location. C1 USA,CECOM,FT MONMOUTH,NJ 07703. RP Lee, CS (reprint author), SO METHODIST UNIV,DEPT ELECT ENGN,DALLAS,TX 75275, USA. NR 4 TC 8 Z9 8 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD OCT PY 1996 VL 44 IS 10 BP 1426 EP 1427 PG 2 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA VK650 UT WOS:A1996VK65000016 ER PT J AU Iafrate, GJ Stroscio, MA AF Iafrate, GJ Stroscio, MA TI Application of quantum-based devices: Trends and challenges SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article ID LOGIC GATES; WIRES; DYNAMICS; DOTS RP Iafrate, GJ (reprint author), USA,RES OFF,RES TRIANGLE PK,NC 27709, USA. NR 23 TC 12 Z9 12 U1 1 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD OCT PY 1996 VL 43 IS 10 BP 1621 EP 1625 DI 10.1109/16.536805 PG 5 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA VH846 UT WOS:A1996VH84600003 ER PT J AU Gualtieri, JG Kosinski, JA AF Gualtieri, JG Kosinski, JA TI Large-area, real-time imaging system for surface acoustic wave devices SO IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT LA English DT Article ID RESONATORS AB A system for imaging the particle displacement envelope of vibrational (transverse) modes of surface acoustic wave (SAW) devices is described, The modes are being imaged using a schlieren method for visualizing the acoustic power flow with a beam-expanded helium-neon (HeNe) laser, The optical arrangement uses internal reflection from within the quartz substrate to achieve high-efficiency acousto-optic diffraction of the laser light, The use of a CCD camera coupled with a frame grabber and a computer with image calculator software establishes an imaging system for large-area, real-time visualization, recording, accurate measurement, and analysis of vibrational modes of SAW devices, These methods are part of an effort to determine the relationship between acceleration sensitivity and transverse variations in the acoustic-mode shape in SAW resonators, Use of the system in imaging a 98 MHz SAW device is presented as an example. C1 USA,RES LAB,AMSRL,PS,ED,FT MONMOUTH,NJ 07703. RP Gualtieri, JG (reprint author), GEO CENTERS INC,EATONTOWN,NJ 07724, USA. NR 12 TC 7 Z9 7 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9456 J9 IEEE T INSTRUM MEAS JI IEEE Trans. Instrum. Meas. PD OCT PY 1996 VL 45 IS 5 BP 872 EP 878 DI 10.1109/19.536704 PG 7 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA VH477 UT WOS:A1996VH47700006 ER PT J AU Cohen, D Ashkenazi, S Green, M Lerman, Y Slepon, R Robin, G Orr, N Taylor, DN Sadoff, JC Chu, CY Shiloach, J Schneerson, R Robbins, JB AF Cohen, D Ashkenazi, S Green, M Lerman, Y Slepon, R Robin, G Orr, N Taylor, DN Sadoff, JC Chu, CY Shiloach, J Schneerson, R Robbins, JB TI Safety and immunogenicity of investigational Shigella conjugate vaccines in Israeli volunteers SO INFECTION AND IMMUNITY LA English DT Article ID LIPOPOLYSACCHARIDE O-ANTIGEN; INFLUENZAE TYPE-B; SERUM ANTIBODIES; CAPSULAR POLYSACCHARIDE; IMMUNOGLOBULIN-A; PERIPHERAL-BLOOD; SONNEI; EPIDEMIOLOGY; TRANSMISSION; IMMUNIZATION AB The safety and immunogenicity of investigational conjugates, composed of the O-specific polysaccharides of Shigella sonnei and Shigella flexneri type 2a covalently bound to Pseudomonas aeruginosa recombinant exoprotein A (rEPA), were evaluated in 192 Israeli soldiers. None had significant local reactions or fever, Fourteen days after injection, 90% of S. sonnei-rEPA recipients and 73 to 77% of S. flexneri-rEPA recipients had a fourfold or greater increase in serum immunoglobulin G (IgG) and IgA anti-lipopolysaccharide (anti-LPS) levels; at 2 years, these remained higher than at prevaccination (P < 0.01), There was a fourfold or greater increase in IgM anti-LPS in 20% of vaccinees at 2 weeks, but levels returned to prevaccination values at 6 to 12 months, IgG was the highest and most sustained class of LPS antibodies. Reinjection at day 42 did not boost antibody levels, Eighteen of 23 (78%) who received S. sonnei-rEPA and 13 of 19 (68%) who received S. flexneri-rEPA had significant IgA-secreting cell responses, Significant IgG antibody-secreting cell responses were detected in 19 of 23 (83%) and 11 of 19 (58%) volunteers following vaccination with S. sonnei-rEPA and S. flexneri 2a-rEPA, respectively, On the basis of these data, further evaluation of the Shigella conjugates for protective efficacy in field trials in Israel was started. C1 TEL AVIV UNIV,SACKLER SCH MED,IL-69978 RAMAT AVIV,TEL AVIV,ISRAEL. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NICHHD,DEV & MOL IMMUN LAB,BETHESDA,MD 20892. NIDDK,BIOTECHNOL UNIT,BETHESDA,MD 20892. RP Cohen, D (reprint author), ISRAEL DEF FORCES MED CORPS,MIL POST 02149,JERUSALEM,ISRAEL. NR 25 TC 47 Z9 53 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD OCT PY 1996 VL 64 IS 10 BP 4074 EP 4077 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA VJ794 UT WOS:A1996VJ79400018 PM 8926071 ER PT J AU Nagineni, CN Pardhasaradhi, K Martins, MC Detrick, B Hooks, JJ AF Nagineni, CN Pardhasaradhi, K Martins, MC Detrick, B Hooks, JJ TI Mechanisms of interferon-induced inhibition of Toxoplasma gondii replication in human retinal pigment epithelial cells SO INFECTION AND IMMUNITY LA English DT Article ID GAMMA-INTERFERON; OCULAR TOXOPLASMOSIS; HUMAN-FIBROBLASTS; HUMAN MACROPHAGES; BETA-INTERFERON; GENE-EXPRESSION; PROTECTIVE ROLE; IFN-GAMMA; GROWTH; CYTOKINES AB Inflammation associated with retinochoroiditis is a major complication of ocular toxoplasmosis in infants and immunocompetent individuals. Moreover, Toxoplasma gondii-induced retinal disease causes serious complications in patients with AIDS and transplant patients. The retinal pigment epithelial (RPE) cell is an important regulatory cell within the retina and is one of the cells infected with T. gondii in in vivo. We have developed a human RPE (HRPE) cell in vitro model system to evaluate T. gondii replication and the regulation of this replication by cytokines. T. gondii replication was quantitated by counting the foci of infection (plaque formation) and the numbers of tachyzoites released into the supernatant fluids. Pretreatment of cultures with recombinant human tumor necrosis factor alpha, alpha interferon (IFN-alpha), IFN-beta, or IFN-gamma for 24 h prior to inoculation inhibited T. gondii replication in a dose-dependent manner. Of these cytokines, IFN-gamma was the most potent, and T. gondii replication was completely inhibited at a concentration of 100 U/ml. The anti-toxoplasmotic activity of IFN-gamma was significantly blocked by monoclonal antibody to IFN-gamma. Treatment of the cultures with IFN-gamma from day 1 or 2 postinoculation with T. gondii also offered protection against the parasite. The anti toxoplasmotic activity of tumor necrosis factor alpha or IFN-alpha, -beta, or -gamma in these cultures was found to be independent of the nitric oxide (NO) pathway, since NO production was not found in HRPE cells treated with these cytokines. However, addition of tryptophan to IFN-gamma-treated cells significantly reversed the inhibitory effects of IFN-gamma, suggesting that IFN-gamma acts by depleting cellular tryptophan. This effect was further confirmed by reverse transcription-PCR and Northern (RNA) blot analysis, which indicated induction of indoleamine 2,3-dioxygenase (IDO), an enzyme that converts tryptophan to kynurenine. These results indicated that interferons inhibited T. gondii replication in HRPE by NO-independent but IDO-dependent mechanisms. This in vitro model of T. gondii replication in HRPE may be useful in evaluating the effects of cytokines and drugs on T. gondii replication within the retina. C1 NEI,IMMUNOL LAB,IMMUNOL & VIROL SECT,NIH,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,DIV BIOCHEM,WASHINGTON,DC 20307. GEORGE WASHINGTON UNIV,MED CTR,DEPT PATHOL,WASHINGTON,DC 20037. NR 54 TC 103 Z9 108 U1 1 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD OCT PY 1996 VL 64 IS 10 BP 4188 EP 4196 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA VJ794 UT WOS:A1996VJ79400034 PM 8926087 ER PT J AU Lindler, LE Hadfield, TL Tall, BD Snellings, NJ Rubin, FA Vandeverg, LL Hoover, D Warren, RL AF Lindler, LE Hadfield, TL Tall, BD Snellings, NJ Rubin, FA Vandeverg, LL Hoover, D Warren, RL TI Cloning of a Brucella melitensis group 3 antigen gene encoding Omp28, a protein recognized by the humoral immune response during human brucellosis (vol 64, pg 2498, 1996) SO INFECTION AND IMMUNITY LA English DT Correction, Addition C1 ARMED FORCES INST PATHOL,DEPT INFECT & PARASIT DIS,WASHINGTON,DC 20306. US FDA,CTR FOOD SAFETY & APPL NUTR,WASHINGTON,DC 20204. RP Lindler, LE (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD OCT PY 1996 VL 64 IS 10 BP 4414 EP 4414 PG 1 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA VJ794 UT WOS:A1996VJ79400072 ER PT J AU Nesvig, EM AF Nesvig, EM TI More kudos SO INTECH LA English DT Letter C1 ERDCO Engn Corp, Evanston, IL 60204 USA. RP Nesvig, EM (reprint author), ERDCO Engn Corp, Evanston, IL 60204 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INSTRUMENT SOC AMER PI RES TRIANGLE PK PA 67 ALEXANDER DRIVE, RES TRIANGLE PK, NC 27709 USA SN 0192-303X J9 INTECH JI Intech PD OCT PY 1996 BP 12 EP 12 PG 1 WC Engineering, Multidisciplinary; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA V2974 UT WOS:000169019200002 ER PT J AU Witmer, BG Bailey, JH Knerr, BW Parsons, KC AF Witmer, BG Bailey, JH Knerr, BW Parsons, KC TI Virtual spaces and real world places: Transfer of route knowledge SO INTERNATIONAL JOURNAL OF HUMAN-COMPUTER STUDIES LA English DT Article AB It has been widely suggested, but rarely demonstrated, that virtual environments (VEs) are effective training media. The purpose of this investigation was to evaluate how well a VE model of a complex office building trained individuals to navigate in the actual building. Sixty participants studied route directions and landmark photographs, then rehearsed the route using either the VE model, the actual building, or verbal directions and photographs. The VE model was presented in real time via a head-tracked display. Half of the participants in each rehearsal group also studied route maps. Everyone's route knowledge was then measured in the actual building. Building configuration knowledge was also measured. VE rehearsal produced more route knowledge than verbal rehearsal, but less than with rehearsal in the actual building. Type of rehearsal had no effect on configuration knowledge. Map study influenced neither route nor configuration knowledge. These results suggest that VEs that adequately represent real world complexity can be effective training media for learning complex routes in buildings, and should be considered whenever the real world site is unavailable for training. (C) 1996 Academic Press Limited C1 UNIV CENT FLORIDA,INST SIMULAT & TRAINING,ORLANDO,FL 32826. RP Witmer, BG (reprint author), USA,RES INST,SIMULATOR SYST RES UNIT,12350 RES PKWY,ORLANDO,FL 32826, USA. NR 25 TC 158 Z9 159 U1 1 U2 9 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 1071-5819 J9 INT J HUM-COMPUT ST JI Int. J. Hum.-Comput. Stud. PD OCT PY 1996 VL 45 IS 4 BP 413 EP 428 DI 10.1006/ijhc.1996.0060 PG 16 WC Computer Science, Cybernetics; Ergonomics; Psychology, Multidisciplinary SC Computer Science; Engineering; Psychology GA VL853 UT WOS:A1996VL85300003 ER PT J AU Seegar, WS Cutchis, PN Fuller, MR Suter, JJ Bhatnagar, V Wall, JG AF Seegar, WS Cutchis, PN Fuller, MR Suter, JJ Bhatnagar, V Wall, JG TI Fifteen years of satellite tracking development and application to wildlife research and conservation SO JOHNS HOPKINS APL TECHNICAL DIGEST LA English DT Article ID BALD EAGLES; TRANSMITTER; LOAD AB A small satellite-based tracking system that is light enough to be carried on birds was developed in the 1980s at the Applied Physics Laboratory. A new, more capable generation is now under development that will contain, in addition to the Argos tracking platform transmitter terminal, a global positioning system receiver and a complement of advanced sensors. The sensors may include a digital audio capture system and a black-and-white charge-coupled device camera. The history of the program and plans for future development are discussed. RP Seegar, WS (reprint author), USA, EDGEWOOD RES & DEV CTR, WASHINGTON, DC 20310 USA. NR 18 TC 14 Z9 18 U1 1 U2 7 PU JOHNS HOPKINS UNIV PI LAUREL PA APPLIED PHYSICS LABORATORY ATTN: TECHNICAL DIGEST JOHN HOPKINS RD, BLDG 1W-131, LAUREL, MD 20723-6099 USA SN 0270-5214 J9 J HOPKINS APL TECH D JI Johns Hopkins APL Tech. Dig. PD OCT-DEC PY 1996 VL 17 IS 4 BP 401 EP 411 PG 11 WC Engineering, Multidisciplinary SC Engineering GA VM543 UT WOS:A1996VM54300007 ER PT J AU Roberts, AC Butterfield, GE Cymerman, A Reeves, JT Wolfel, EE Brooks, GA AF Roberts, AC Butterfield, GE Cymerman, A Reeves, JT Wolfel, EE Brooks, GA TI Acclimatization to 4,300-m altitude decreases reliance on fat as a substrate SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE exertion; adaptation; metabolism; free fatty acids; glycerol; lipolysis; glucose; hypoxia ID OPERATION EVEREST-II; GLUCOSE-TURNOVER; EXERCISING DOGS; METABOLISM; MUSCLE; DEPENDENCE; RESPONSES; HYPOXIA; HUMANS; ACIDS AB We tested the hypothesis that exposure to altitude decreases reliance on free fatty acids (FFA) as substrates and increases dependency on blood glucose. Therefore, the effects of exercise, hypobaric hypoxia, and altitude acclimatization on FFA, glycerol and net glucose uptake and release [= 2(leg blood flow)(arteriovenous concentration)] and on fatty acid (FA) consumption by the legs (= 3 x glycerol release + FFA uptake) were measured. Because sympathetic responses have been implicated, we utilized nonspecific beta-blockade and observed responses to exercise, altitude, and altitude acclimatization. We studied six healthy beta-blocked men (beta) and five matched controls (C) during rest and cycle ergometry exercise (88 W) at 49% of sea-level (SL) peak O-2 uptake at the same absolute power output on acute altitude exposure (A1; barometric pressure = 430 Torr) and after 3 wk of chronic altitude exposure to 4,300 m (A2). During exercise at SL, FA consumption rates increased (P < 0.05). On arrival at 4,300 m, resting leg FFA uptake and FA consumption rates were not significantly different from those at SL. However, after acclimatization to altitude, at rest leg FA consumption decreased to essentially zero in both C and beta groups. During exercise at altitude after acclimatization, leg FA consumption increased significantly, but values were less than at SL or A1 (P < 0.05), whereas glucose uptake increased relative to SL values. Furthermore, beta-blockade significantly increased glucose uptake relative to control. We conclude that 1) chronic altitude exposure decreases leg FA consumption during rest and exercise; 2) relative to SL, FFA uptake decreases while glucose uptake increases during exercise at altitude; and 3) beta-blockade potentiates these effects. C1 UNIV CALIF BERKELEY,DEPT HUMAN BIODYNAM,EXERCISE PHYSIOL LAB,BERKELEY,CA 94720. VET AFFAIRS MED CTR,CTR GERIATR RES EDUC & CLIN,PALO ALTO,CA 95304. UNIV COLORADO,HLTH SCI CTR,DENVER,CO 80262. USA,ENVIRONM MED RES INST,NATICK,MA 01760. OI Brooks, George A./0000-0002-1389-1629 FU NIAMS NIH HHS [AR-42906] NR 30 TC 94 Z9 97 U1 1 U2 13 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD OCT PY 1996 VL 81 IS 4 BP 1762 EP 1771 PG 10 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA VM563 UT WOS:A1996VM56300045 PM 8904597 ER PT J AU Cameron, KL Kersey, RD Ransone, J AF Cameron, KL Kersey, RD Ransone, J TI Avulsion of the inferior canaliculus in a collegiate wrestler: A case study SO JOURNAL OF ATHLETIC TRAINING LA English DT Article DE lacrimal system; canthal tendon; laceration ID SILICONE INTUBATION; PIGTAIL PROBE; LACERATIONS AB Objective: The purpose of this case study is to aid sports health care personnel in understanding the accurate identification and treatment of traumatic sports injuries involving structures of the lacrimal system. Background: A 21-year-old, 118-pound wrestler sustained an avulsion of the inferior canaliculus of the right eye during a match. The injury resulted when the athlete was struck on the right cheek by the opponent's head, producing an inferior and lateral force. Following the initial control of hemorrhage, the athlete was permitted to complete the match. Upon initial evaluation, it was determined that the medial aspect of the lower right lid had been avulsed. The injury was approximately 1 cm in length. The athlete completed the match before being referred to the hospital for further evaluation. Differential Diagnosis: Avulsion of the medial one-sixth of the tower right eyelid, involving damage to the inferior canaliculus and complete avulsion of the inferior medial canthal tendon. Treatment: Surgical intervention was indicated in order to restore the lacrimal drainage system and to ensure patency of the inferior canaliculus. A bicanalicular silicon intubation procedure was utilized by the physician. initial postoperative treatment included the application of topical antibiotics for seven days. The athlete was permitted to return to full participation within 1 week with the use of a wrestling face mask. The superficial sutures were removed 14 days following surgery and at that time the athlete was cleared for unrestricted activity. The silicon-reinforced medial canthal tendon suture was removed 6 weeks following surgical repair. The bicanalicular silicon stent was removed 6 months following initial injury and surgical intervention. No complications were noted throughout the 6-month postoperative stage or at the time of a follow-up interview 2 years postinjury. Uniqueness: This is a relatively uncommon injury to encounter in athletics and one that has not been well addressed in the existing sports medicine literature. Conclusions: When injury to the medial aspect of the eye occurs, recognition of the potential for lacrimal system involvement is essential. Therefore, the athletic trainer should be familiar with the anatomy of the lacrimal system and the potential for such injuries. C1 SAN JOSE STATE UNIV,DEPT HUMAN PERFORMANCE,SAN JOSE,CA 95192. RP Cameron, KL (reprint author), US MIL ACAD,DEPT PHYS EDUC,W POINT,NY 10996, USA. NR 13 TC 0 Z9 0 U1 0 U2 0 PU NATL ATHLETIC TRAINERS ASSOC INC PI DALLAS PA 2952 STEMMONS FREEWAY, DALLAS, TX 75247 SN 1062-6050 J9 J ATHL TRAINING JI J. Athl. Train. PD OCT-DEC PY 1996 VL 31 IS 4 BP 352 EP 355 PG 4 WC Sport Sciences SC Sport Sciences GA WA362 UT WOS:A1996WA36200012 PM 16558423 ER PT J AU Shaker, M Kamel, I Ko, F Song, JW AF Shaker, M Kamel, I Ko, F Song, JW TI Improvement of the interfacial adhesion between Kevlar fiber and resin by using R-F plasma SO JOURNAL OF COMPOSITES TECHNOLOGY & RESEARCH LA English DT Article DE Kevlar fiber; epoxy; plasma treatment; interfacial adhesion; monomer AB The interfacial adhesion between fiber and matrix has a significant effect on the overall performance of a composite. The necessity of binding the fibers together in a structural composite creates the need for an enhanced interfacial bond between fibers and matrix. One possibility to change the fiber/matrix bond in composite materials is to modify the surface of the reinforcing fiber. One technology useful for this purpose is plasma treatment. This paper discusses optimizing R-F plasma polymerization of allylamine onto Kevlar 29 and KM2 fibers. The treatment was carried out in two steps. First, the fiber was treated with Argon; second, the fiber was treated by allylamine. A method was found such that, under such optimum treatment conditions, the plasma treatment does not adversely affect the mechanical properties of the fibers. This allows flexibility in the tailoring of interfacial properties to optimize the energy absorption capability of the composites. A method was also found that increases interfacial adhesion between PPTA fiber (Kevlar) filament and the matrix as the thickness of the plasma allylamine coating increases. C1 USA,NATICK RES DEV & ENGN CTR,FIBER & POLYMER SCI DIV,SCI & TECHNOL DIRECTORATE,NATICK,MA 01760. RP Shaker, M (reprint author), DREXEL UNIV,DEPT MAT ENGN,PHILADELPHIA,PA 19104, USA. NR 6 TC 26 Z9 29 U1 0 U2 5 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0884-6804 J9 J COMPOS TECH RES JI J. Compos. Technol. Res. PD OCT PY 1996 VL 18 IS 4 BP 249 EP 255 PG 7 WC Materials Science, Composites; Polymer Science SC Materials Science; Polymer Science GA VN882 UT WOS:A1996VN88200002 ER PT J AU East, EW Fu, MC AF East, EW Fu, MC TI Abstracting lessons learned from design reviews SO JOURNAL OF COMPUTING IN CIVIL ENGINEERING LA English DT Article AB The application of lessons learned during construction to future designs is a goal of many construction organizations. This paper presents the current status of design review systems within the U.S. Army Corps of Engineers, and describes a new computer program, the Lessons-Learned Generator, that abstracts frequently used design review comments. Frequently used comments in the Reviewer's Assistant system are evaluated based on usefulness, generality, and content stability. Well-formed comments are then abstracted and included in a new Reviewer's Assistant project. The abstraction process keeps the growth of the database at a reasonable level and allows users to identify and distribute sets of repetitive comments. Difficulties associated with the automated abstraction of lessons learned are discussed. Since the Lessons-Learned Generator identifies lessons learned as part of a reviewer's daily business practice, then makes the lessons-learned immediately accessible within the Reviewer's Assistant system, this approach may be more effective than paper checklists or stand-alone automation approaches for applying lessons learned. C1 UNIV ILLINOIS, BECKMAN INST 1514, DEPT COMP SCI, URBANA, IL 61801 USA. RP USA, CORPS ENGINEERS, CONSTRUCT ENGN RES LAB, CECER PL E, POB 9005, CHAMPAIGN, IL 61826 USA. NR 19 TC 4 Z9 4 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0887-3801 EI 1943-5487 J9 J COMPUT CIVIL ENG JI J. Comput. Civil. Eng. PD OCT PY 1996 VL 10 IS 4 BP 267 EP 275 DI 10.1061/(ASCE)0887-3801(1996)10:4(267) PG 9 WC Computer Science, Interdisciplinary Applications; Engineering, Civil SC Computer Science; Engineering GA VH866 UT WOS:A1996VH86600004 ER PT J AU Lareau, RT Jones, KA Monahan, T Flemish, JR Pfeffer, RL Sherriff, RE Litton, CW Jones, R Stutz, CE Look, DC AF Lareau, RT Jones, KA Monahan, T Flemish, JR Pfeffer, RL Sherriff, RE Litton, CW Jones, R Stutz, CE Look, DC TI Comparison of OMVPE and MBE grown AlGaAs/InGaAs PHEMT structures SO JOURNAL OF CRYSTAL GROWTH LA English DT Article ID HETEROSTRUCTURES AB delta-doped PHEMT structures commercially grown by OMVPE and MBE on 3 inch wafers were examined using contactless resistance, magneto-Hall, PR, FL, DXRD, RES, SIMS, and electrochemical capacitance-voltage measurements, and 0.1 mu m gate length devices were fabricated from them and then characterized. The electron mobilities in the OMVPE 2DEG were a little smaller than those in the MBE DEG, but were still excellent, and the carrier concentrations, which were > 2.5 x 10(12) cm(-2) at 77 K, were similar. The interface quality as measured by PR spectra was a little better in the MBE sample. Variation in the In areal density as determined by RES Was a little larger in the OMVPE wafer, but it was still less than 1 at%. The sheet resistance and the doping concentration as determined by SIMS and EC-V measurements showed the variation in the OMVPE wafers was slightly larger, but it was still considered to be small. PHEMTs fabricated from the most promising OMVPE wafer had g(m)'s (753 mS/mm) that approached those for the MBE wafer (796 mS/mm) as did their f(T)'s (115 versus 117 GHz). The variations in these parameters were also found to be slightly larger in the OMVPE wafers. C1 ERL WRIGHT PATTERSON AFB,WRIGHT LAB,DAYTON,OH 45433. WRIGHT STATE UNIV,DAYTON,OH 45435. RP Lareau, RT (reprint author), USA,RES LAB,PSD,AMSRL PS DB,FT MONMOUTH,NJ 07703, USA. NR 7 TC 0 Z9 0 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 J9 J CRYST GROWTH JI J. Cryst. Growth PD OCT PY 1996 VL 167 IS 3-4 BP 406 EP 414 DI 10.1016/0022-0248(96)00340-5 PG 9 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA VN986 UT WOS:A1996VN98600002 ER PT J AU Osenbach, RK AF Osenbach, RK TI Isolated extranodal sinus histiocytosis presenting as an intramedullary spinal cord tumor with paraplegia - Case report SO JOURNAL OF NEUROSURGERY LA English DT Article DE sinus histiocytosis; Rosai-Dorfman disease; lymphadenopathy; spinal cord ID ROSAI-DORFMAN DISEASE; MASSIVE LYMPHADENOPATHY; INVOLVEMENT; MANIFESTATIONS AB Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) is a nonneoplastic lymphoproliferative disorder that usually presents with massive painless cervical lymphadenopathy accompanied by fever and weight loss. Extranodal involvement occurs in over 40% of patients; however, isolated extranodal disease without lymph node involvement is unusual. Extranodal involvement of the nervous system is unusual and isolated central nervous system disease in the absence of nodal disease is distinctly ran. The author describes the case of a 35-year-old man who presented with paraplegia and an enhancing intramedullary lesion on magnetic resonance imaging that was suggestive of a primary spinal cord tumor. The lesion was completely resected and histologically proved to be consistent with an isolated extranodal case of Rosai-Dorfman disease. Although a number of cases of this entity involving the CNS have been published, the author believes this case represents the first report of intramedullary spinal cord involvement as the initial and only sign of disease. RP Osenbach, RK (reprint author), WALTER REED ARMY MED CTR,DIV NEUROSURG,ROOM 6C13,WASHINGTON,DC 20307, USA. NR 24 TC 34 Z9 34 U1 0 U2 1 PU AMER ASSOC NEUROLOGICAL SURGEONS PI CHARLOTTESVILLE PA UNIV VIRGINIA, 1224 WEST MAIN ST, STE 450, CHARLOTTESVILLE, VA 22903 SN 0022-3085 J9 J NEUROSURG JI J. Neurosurg. PD OCT PY 1996 VL 85 IS 4 BP 692 EP 696 DI 10.3171/jns.1996.85.4.0692 PG 5 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA VJ247 UT WOS:A1996VJ24700027 PM 8814178 ER PT J AU Fowler, EB Cuenin, MF Thompson, SH Kudryk, VL Billman, MA AF Fowler, EB Cuenin, MF Thompson, SH Kudryk, VL Billman, MA TI Pyogenic granuloma associated with guided tissue regeneration: A case report SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE bone, freeze-dried; bone, grafts; bone, demineralized; guided tissue regeneration; granuloma, pyogenic; membranes, artificial; membranes, barrier; polytetrafluoroethylene therapeutic use; alveolar process; mucous membrane AB A pyogenic granuloma is an exuberant growth of granulation tissue secondary to irritation. intraorally, it can present with a wide array of clinical appearances, ranging from a sessile lesion to an elevated mass. Pyogenic granulomas generally are soft, painless, and deep red to reddish-purple in color. They are usually 0.5 to 1.0 cm in diameter, more common in females, and often found on the keratinized tissue. This case is interesting because the pyogenic granuloma was found associated with guided tissue regeneration and the lingual alveolar mucosa. The lesion arose after demineralized freeze dried bone allograft and an expanded polytetrafluoroethylene (ePTFE) membrane were utilized to repair osseous defects. Five weeks after surgery, the patient presented for routine follow-up where suppuration associated with the membrane was noted along with an exophytic growth of the lingual alveolar mucosa. The ePTFE membrane was removed alone with an excisional biopsy of one of the growths. By 10 days after the removal of ePTFE, the lesion spontaneously healed. Histologic evaluation of the tissue was consistent with a pyogenic granuloma. This is the first case in the literature of a pyogenic granuloma associated with a routine guided tissue regenerative surgery using a non-resorbable membrane and allograft. C1 USA,DENT ACTIV,PERIODONT RESIDENCY PROGRAM,DEPT ORAL PATHOL,FT GORDON,GA 30905. RP Fowler, EB (reprint author), USA,DENT ACTIV,PERIODONT RESIDENCY PROGRAM,DEPT PERIODONT,FT GORDON,GA 30905, USA. NR 12 TC 4 Z9 6 U1 0 U2 0 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD OCT PY 1996 VL 67 IS 10 BP 1011 EP 1015 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA VP282 UT WOS:A1996VP28200009 PM 8910841 ER PT J AU Keeble, DJ Li, Z Harmatz, M AF Keeble, DJ Li, Z Harmatz, M TI Electron paramagnetic resonance of Cu2+ in PbTiO3 SO JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS LA English DT Article; Proceedings Paper CT 3rd Williamsburg Workshop on Fundamental Experiments on Ferroelectrics CY FEB 05-08, 1995 CL WILLIAMSBURG, VA SP USN, Office Naval Res DE electron paramagnetic resonance; ferroelectricity; crystal fields; defects ID SINGLE-CRYSTALS; BATIO3; RES; CERAMICS; SRTIO3; EPR; FE AB The electron paramagnetic resonance spectrum of Cu2+ in tetragonal-phase single-crystal lead titanate has been studied at 9.8 GHz. An axial spectrum with \g(parallel to)\ = 2.340(1) and \g(perpendicular to)\ = 2.058(1) was measured and fitted using the spin-Hamiltonian parameters \(63)A(parallel to)\ = 155(2) x 10(-4) cm(-1), \(63)A(perpendicular to)\ = 5.4(2.0) x 10(-4) cm(-1), \(65)A(parallel to)\ = 166(2) x 10(-4) cm(-1), and \(65)A(parallel to)\ = 5.8(2.0) x 10(-4) cm(-1). The observed g-values are consistent with a d(9)-configuration ion at a tetragonally distorted octahedral site from which it is inferred that Cu2+ substitutes at the Ti-site. C1 ARGONNE NATL LAB,DIV MAT SCI,ARGONNE,IL 60439. USA,RES LAB,FT MONMOUTH,NJ 07703. RP Keeble, DJ (reprint author), UNIV DUNDEE,DEPT APPL PHYS & ELECT & MFG ENGN,CARNEGIE LAB PHYS,DUNDEE DD1 4DH,SCOTLAND. RI Keeble, David /C-6633-2012 OI Keeble, David /0000-0002-5378-799X NR 33 TC 18 Z9 18 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0022-3697 J9 J PHYS CHEM SOLIDS JI J. Phys. Chem. Solids PD OCT PY 1996 VL 57 IS 10 BP 1513 EP 1515 DI 10.1016/0022-3697(96)00021-2 PG 3 WC Chemistry, Multidisciplinary; Physics, Condensed Matter SC Chemistry; Physics GA VK053 UT WOS:A1996VK05300022 ER PT J AU Zheng, JP Jow, TR AF Zheng, JP Jow, TR TI High energy and high power density electrochemical capacitors SO JOURNAL OF POWER SOURCES LA English DT Article DE capacitors; ruthenium; energy density AB High energy density electrochemical capacitors were built with a newly discovered electrode material (amorphous RuO2 . xH(2)O). Energy densities as high as 96 J/g (26 Wh/kg) were obtained based on the RuO2 . xH(2)O electrode material alone. However, the power density of the capacitor is low. By mixing RuO2 . xH(2)O powders with about 20% weight of carbon black, power densities greater than 10 kW/kg could be achieved at a delivered energy density of about 72 J/g (20 Wh/kg). Capacitance as a function of cycle life was studied for up to 60 000 cycles. The temperature dependence of capacitance and resistance of the capacitor are also reported in this paper. RP Zheng, JP (reprint author), USA,RES LAB,ELECT & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703, USA. NR 16 TC 198 Z9 224 U1 5 U2 41 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD OCT PY 1996 VL 62 IS 2 BP 155 EP 159 DI 10.1016/S0378-7753(96)02424-X PG 5 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA VZ794 UT WOS:A1996VZ79400002 ER PT J AU Marcuson, WF AF Marcuson, WF TI Rationale for requiring a master's degree on civil engineering for professional registration SO JOURNAL OF PROFESSIONAL ISSUES IN ENGINEERING EDUCATION AND PRACTICE LA English DT Article RP Marcuson, WF (reprint author), USA,CORPS ENGINEERS,WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 1052-3928 J9 J PROF ISS ENG ED PR JI J. Prof. Issues Eng. Educ. Pract. PD OCT PY 1996 VL 122 IS 4 BP 140 EP 140 PG 1 WC Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA VH566 UT WOS:A1996VH56600003 ER PT J AU Marcuson, WF AF Marcuson, WF TI On civil engineering education - Response SO JOURNAL OF PROFESSIONAL ISSUES IN ENGINEERING EDUCATION AND PRACTICE LA English DT Article RP Marcuson, WF (reprint author), USA,CORPS ENGINEERS,GEOTECH LAB,WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 1052-3928 J9 J PROF ISS ENG ED PR JI J. Prof. Issues Eng. Educ. Pract. PD OCT PY 1996 VL 122 IS 4 BP 145 EP 146 PG 2 WC Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA VH566 UT WOS:A1996VH56600013 ER PT J AU Atassi, MZ Dolimbek, BZ Hayakari, M Middlebrook, JL Whitney, B Oshima, M AF Atassi, MZ Dolimbek, BZ Hayakari, M Middlebrook, JL Whitney, B Oshima, M TI Mapping of the antibody-binding regions on botulinum neurotoxin H-chain domain 855-1296 with antitoxin antibodies from three host species SO JOURNAL OF PROTEIN CHEMISTRY LA English DT Article DE Botulinum neurotoxin; synthetic peptides; antibodies; epitopes ID NUCLEOTIDE-SEQUENCE ANALYSIS; SPERM-WHALE MYOGLOBIN; AMINO-ACID-SEQUENCE; COMPREHENSIVE SYNTHETIC APPROACH; PROTEIN ANTIGENIC STRUCTURES; T PROLIFERATIVE RESPONSE; TETANUS TOXIN; IMMUNE-RESPONSE; GENETIC-CONTROL; A NEUROTOXIN AB Botulism due to food poisoning is caused mainly by protein toxins, botulinum neurotoxins (BoNTs), produced by Clostridium botluinum in seven known immunological serotypes. These are the most potent toxins and poisons known. BoNT effects blockade of neuromuscular transmission by preventing neurotransmitter release. Human botulism is most frequently caused by types A, B, and E. Recent studies have shown that immunization with a 43-kDa C-terminal fragment (H-c, residues 860-1296) of BoNT/A affords excellent protection against BoNT/A poisoning. We raised antibodies (Abs) against BoNT/A in horse, and against pentavalent toroid (BoNTs A, B, C, D, E) in human volunteers and outbred mice. Thirty-one 19-residue peptides that started at residue 855, overlapped consecutively by 5 residues, and encompassed the entire length of the H, of BoNT/A were synthesized and used for mapping the Ab-binding regions recognized by the anti-BoNT/A antisera. Horse Abs against BoBT/A were bound by peptides 855-873, 939-957, 1079-1097/1093-1111 overlap, 1191-1209/1205-1223 overlap, 1261-1279 and 1275-1296. In addition, peptides 883-901, 911-929, 995-1013, 1023-1041/1037-1055 overlap, 1121-1139, and 1149-1167 gave low, but significant and reproducible, binding. With human antisera, high amounts of Abs were bound by peptides 869-887, 925-943, 981-999, 995-1013, 1051-1069, and 1177-1195. In addition, lower amounts of Abs were bound by peptides 911-929, 939-957, 967-985, and the overlaps 1121-1139/1135-1153 and 1247-1265/1261-1279/1275-1296. With outbred mouse antisera, high amounts of Abs were bound by peptides 869-887, 1051-1069, and 1177-1195, while peptides 939-957, 995-1013, 1093-1111, and 1275-1296 bound lower amounts of Abs. The results indicate that horse antiserum against BoNT/A or human and mouse (outbred) antisera against the toroid recognized similar regions on BoNT/A, but exhibited some boundary frame shifts and differences in immunodominance of these regions among the antisera. Selected synthetic epitopes will be used as immunogens to stimulate active or passive (by Ab transfer) immunity against toxin poisoning. C1 USA,DIV LIFE SCI,DUGWYA PROVING GROUND,DUGWAY PROVING GROUND,UT 84022. RP Atassi, MZ (reprint author), BAYLOR COLL MED,VERNA & MARRS MCLEAN DEPT BIOCHEM,HOUSTON,TX 77030, USA. NR 62 TC 58 Z9 59 U1 0 U2 0 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0277-8033 J9 J PROTEIN CHEM JI J. Protein Chem. PD OCT PY 1996 VL 15 IS 7 BP 691 EP 700 DI 10.1007/BF01886751 PG 10 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA VX909 UT WOS:A1996VX90900010 PM 8968960 ER PT J AU DAprano, A Vicens, J Asfari, Z Salomon, M Iammarino, M AF DAprano, A Vicens, J Asfari, Z Salomon, M Iammarino, M TI Complexation of alkali metal cations by calix[4]arene-bis-crown-6 in methanol, acetonitrile and propylene carbonate SO JOURNAL OF SOLUTION CHEMISTRY LA English DT Article DE electrolytic conductance; molar conductance; ion pair formation; complex formation; 18-crown-6; calix[4]arene-bis-crown-6; lithium perchlorate; sodium perchlorate; potassium perchlorate; rubidium perchlorate; cesium perchlorate; acetonitrile; methanol; propylene carbonate ID MACROCYCLIC LIGAND COMPLEXES; CROWN-ETHERS AB The interactions of Li+, Na+, K+, Rb+, and Cs+ with the ''double-crown calix,'' calix[4]arene-bis-crown-6, have been studied in methanol, acetonitrile, and propylene carbonate at 25 degrees C using precise conductivity measurements. For Li+ and Na+ in solutions containing this calix[4]arene, only I:1 cation:ligand complexes are formed which permit the determination of the thermodynamic complexation formation constants, K-f. The conductivity data strongly suggest that 2:1 cation-calixarene complexes form with K+, Rb+, and Cs+. The existence of 2:1 complexes was experimentally confirmed for the potassium systems by a mass spectroscopic method. C1 EUROPEAN HIGHER INST CHEM STRASBOURG,LAB MINERAL & CHIM ANALYT,URA 405 CNRS,F-67008 STRASBOURG,FRANCE. USA,ARL,PSD,CHEM BIOL SCI DIV,FT MONMOUTH,NJ 07703. RP DAprano, A (reprint author), UNIV ROMA LA SAPIENZA,DEPT CHEM,PLE A MORO 5,I-00185 ROME,ITALY. NR 31 TC 16 Z9 16 U1 0 U2 3 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0095-9782 J9 J SOLUTION CHEM JI J. Solut. Chem. PD OCT PY 1996 VL 25 IS 10 BP 955 EP 970 DI 10.1007/BF00972592 PG 16 WC Chemistry, Physical SC Chemistry GA VX869 UT WOS:A1996VX86900004 ER PT J AU Zeidman, SM Ling, GSF Ducker, TB Ellenbogen, RG AF Zeidman, SM Ling, GSF Ducker, TB Ellenbogen, RG TI Clinical applications of pharmacologic therapies for spinal cord injury SO JOURNAL OF SPINAL DISORDERS LA English DT Article DE pharmacotherapy; spinal cord; glucocorticosteroids ID FREE-RADICAL SCAVENGER; VENTRAL COMPRESSION MODEL; 21-AMINOSTEROID U74006F; GM-1 GANGLIOSIDE; TIRILAZAD MESYLATE; NALOXONE TREATMENT; STEROID-THERAPY; MOTOR FUNCTION; BLOOD-FLOW; METHYLPREDNISOLONE AB We review the evidence supporting the role of glucocorticosteroids, trilazad, and GM(1) ganglioside in spinal cord injury and provide our critique of the published studies, along with our recommendations for pharmacologic therapy for this complex and difficult problem. C1 WALTER REED ARMY MED CTR,DEPT SURG,DIV NEUROSURG,BALTIMORE,MD. NR 72 TC 13 Z9 14 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0895-0385 J9 J SPINAL DISORD JI J. Spinal Disord. PD OCT PY 1996 VL 9 IS 5 BP 367 EP 380 PG 14 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA VU480 UT WOS:A1996VU48000002 PM 8938604 ER PT J AU Grant, KW Walden, BE AF Grant, KW Walden, BE TI Evaluating the articulation index for auditory-visual consonant recognition SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID HEARING-IMPAIRED ADULTS; WORD RECOGNITION; PHONEME AB Adequacy of the ANSI standard for calculating the articulation index (AI) [ANSI S3.5-1969 (R1986)] was evaluated by measuring auditory (A), visual (V), and auditory-visual (AV) consonant recognition under a variety of bandpass-filtered speech conditions. Contrary to ANSI predictions, filter conditions having the same auditory AI did not necessarily result in the same auditory-visual AI. Low-frequency bands of speech tended to provide more benefit to AV consonant recognition than high-frequency bands. Analyses of the auditory error patterns produced by the different filter conditions showed a strong negative correlation between the degree of A and V redundancy and the amount of benefit obtained when A and V cues were combined. These data indicate that the ANSI auditory-visual AI procedure is inadequate for predicting AV consonant recognition performance under conditions of severe spectral shaping. (C) 1996 Acoustical Society of America. RP Grant, KW (reprint author), WALTER REED ARMY MED CTR,ARMY AUDIOL & SPEEC CTR,WASHINGTON,DC 20307, USA. FU NIDCD NIH HHS [DC 00792] NR 32 TC 49 Z9 49 U1 1 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD OCT PY 1996 VL 100 IS 4 BP 2415 EP 2424 DI 10.1121/1.417950 PN 1 PG 10 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA VN885 UT WOS:A1996VN88500049 PM 8865647 ER PT J AU Maggio, KL Singer, MT James, WD AF Maggio, KL Singer, MT James, WD TI Clinical pearl: Discoid lupus erythematosus - Treatment with occlusive compression SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID PROSTHETIC DEVICE; AID RP Maggio, KL (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 4 TC 3 Z9 5 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD OCT PY 1996 VL 35 IS 4 BP 627 EP 628 DI 10.1016/S0190-9622(96)90692-1 PG 2 WC Dermatology SC Dermatology GA WB036 UT WOS:A1996WB03600023 PM 8859295 ER PT J AU Kecskes, LJ Niiler, A Kottke, T Logan, KV Villalobos, GR AF Kecskes, LJ Niiler, A Kottke, T Logan, KV Villalobos, GR TI Dynamic consolidation of combustion-synthesized alumina-titanium diboride composite ceramics SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID HIGH-TEMPERATURE SYNTHESIS; AL2O3-TIC COMPOSITES; CARBIDE CERAMICS; COMPACTION; DENSIFICATION; FABRICATION; OXIDATION; BORIDE; TIB2 AB A mixture of TiO2, B2O3, and Al ponders was reacted exothermically to form a tom-density Al2O3-TiB2 foamed product, After the cessation of the combustion synthesis reaction, this hot foam mas densified by the pressure waves generated by the detonation of an explosive charge. The delay time between the initiation of the combustion synthesis and detonation of the explosive, the thickness of the explosive charge, and the strength of sample confinement were found to influence the effectiveness of the consolidation. Analysis of the combustion synthesis reaction temperature histories and microscopy of the reacted product sponge are used to develop additional information about this reaction/consolidation process, These results, and the microstructural properties of the combustion-synthesized and dynamically consolidated products, are discussed. C1 GEORGIA TECH RES INST,ATLANTA,GA 30332. RP Kecskes, LJ (reprint author), USA,RES LAB,WEAPONS TECHNOL DIRECTORATE,ABERDEEN PROVING GROUND,MD 21005, USA. RI Kecskes, Laszlo/F-6880-2014 OI Kecskes, Laszlo/0000-0002-1342-3729 NR 40 TC 14 Z9 15 U1 0 U2 2 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, PO BOX 6136, WESTERVILLE, OH 43081-6136 SN 0002-7820 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD OCT PY 1996 VL 79 IS 10 BP 2687 EP 2695 PG 9 WC Materials Science, Ceramics SC Materials Science GA VP021 UT WOS:A1996VP02100025 ER PT J AU Stewart, JE AF Stewart, JE TI Two alternative velocity vector cues for the AH-64D: A comparative evaluation SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB The AH-64A employs an integrated helmet and display sight subsystem (IHADSS) presenting night vision system imagery and flight symbology to the pilot's right eye, Velocity vector and acceleration cues tell the pilot when the aircraft is accelerating, its speed, and vector, A low range (0-6 kt) cue is used to minimize velocity and drift variation for hovering and low speed flight, A transition range cue (0-60 kt) is used at speeds > 6 kt, where less sensitivity to velocity change is required, The experiment compared the low range cue to an intermediate range (0-20 kt) cue, proposed for the AH-64D, Ten AH-64A pilots performed a mission consisting of seven standard maneuver tasks, in the Simulator Training Research Advanced Testbed for Aviation, Each performed the mission under IHADSS conditions using low and intermediate range cues (order counterbalanced). Results showed that drift and airspeed variation was significantly less for the low range cue during a stationary five-foot hover; airspeed variation was significantly less in the low range cue condition for hover taxiing, The 100 ft hover revealed no differences. For the hovering turn, turn rate and pedal movement were more constant in the tow range cue condition, but the aircraft appeared less stable, No significant differences were noticed for landing and takeoff tasks. RP Stewart, JE (reprint author), USA,RES INST ROTARY WING,AVIAT RES UNIT,FT RUCKER,AL, USA. NR 8 TC 1 Z9 1 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD OCT PY 1996 VL 41 IS 4 BP 354 EP 359 PG 6 WC Engineering, Aerospace SC Engineering GA VN424 UT WOS:A1996VN42400008 ER PT J AU Ren, F Hobson, WS Lothian, JR Lopata, J Pearton, SJ Caballero, JA Cole, MW AF Ren, F Hobson, WS Lothian, JR Lopata, J Pearton, SJ Caballero, JA Cole, MW TI Extremely high etch rates of in-based III-V semiconductors in Bcl(3)/N-2 based plasma SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID VAPOR-PHASE EPITAXY; INGAP; OPERATION; LASERS AB Extremely high etch rates of InGaP and InP are observed as N-2 is added to BCl3 discharges. The etch rates of similar to 2.0 mu m/min and -1.8 mu m/min for InGaP and InP, respectively, are achieved at 100 degrees C with 1000 W of electron cyclotron resonance power and -145 V self-bias. Optical emission spectra show increases of intensities for Cl-2(+) and Cl+ emissions with the presence of N-2 in BCl3 plasmas as well as an additional BN emission at 385.6 nm. This trend of increasing emission intensity is consistent with the increase of etching rate with BCl3/N-2 discharge. A low threshold current, 9.7 mA, InGaAs/GaAs/InGaP ridge lasers with a ridge width and cavity length of 1.4 and 750 mu m, respectively, were also demonstrated with this etching processing. C1 UNIV FLORIDA,GAINESVILLE,FL 32611. USA,RES LAB,FT MONMOUTH,NJ 07703. RP Ren, F (reprint author), AT&T BELL LABS,LUCENT TECHNOL,600 MT AVE,MURRAY HILL,NJ 07974, USA. NR 14 TC 6 Z9 6 U1 0 U2 0 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD OCT PY 1996 VL 143 IS 10 BP 3394 EP 3396 DI 10.1149/1.1837218 PG 3 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA VP026 UT WOS:A1996VP02600068 ER PT J AU Offner, PJ Ogura, H Jordan, BS Pruitt, BA Cioffi, WG AF Offner, PJ Ogura, H Jordan, BS Pruitt, BA Cioffi, WG TI Cardiopulmonary effects of combined nitric oxide inhibition and inhaled nitric oxide in porcine endotoxic shock SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE nitric oxide; nitric oxide synthase; N-nitro-L-arginine methyl ester; inhaled nitric oxide; sepsis; endotoxemia; cardiopulmonary; pulmonary hypertension ID NITROSO-N-ACETYLPENICILLAMINE; ACUTE INTESTINAL DAMAGE; L-ARGININE; PULMONARY-HYPERTENSION; SYNTHASE INHIBITION; PROTECTIVE ACTIONS; SEPTIC SHOCK; RAT; MODEL; INHALATION AB Background: Nitric oxide synthase (NOS) inhibition has been shown to potentiate lipopolysaccharide (LPS) associated pulmonary hypertension, which may worsen right ventricular (KV) dysfunction and decrease cardiac output during sepsis, This study evaluates whether inhaled nitric oxide can ameliorate the adverse cardiopulmonary effects of NOS inhibition during endotoxemia, Methods: After an infusion of Escherichia coli LPS (200 mu g/kg), animals were resuscitated with saline (1 mL/kg/min) and observed for 3 hours while mechanically ventilated (FIO2, 0.6; V-T, 12 mL/kg; positive end-expiratory pressure, 5 cm H2O). The LPS group (n = 6) received no additional treatment, The N-nitro-L-arginine methyl ester (NAME) group (n = 5) received L-NAME, a NOS inhibitor, 50 mu g/kg/min for the last 2 hours, The NO+NAME group (n = 6) received inhaled NO (40 ppm) and L-NAME for the last 2 hours, The control group (n = 5) received only saline without LPS. Hemodynamic data and blood gases were collected hourly for 3 hours. Results: L-NAME worsened LPS-associated pulmonary hypertension and RV dysfunction as reflected by decreased RV ejection fraction, Inhaled nitric oxide significantly decreased pulmonary hypertension and improved RV ejection fraction and stroke work index, There were no adverse systemic effects. Conclusions: Inhaled nitric oxide reverses pulmonary hypertension seen with L-NAME treatment during endotoxemia and may be a useful adjunct to NOS inhibition in the treatment of septic shock. C1 BROOKE ARMY MED CTR, DEPT SURG, FT SAM HOUSTON, TX 78234 USA. BROOKE ARMY MED CTR, CRIT CARE SERV, FT SAM HOUSTON, TX 78234 USA. USA, INST SURG RES, FT SAM HOUSTON, TX 78234 USA. NR 43 TC 13 Z9 13 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0022-5282 EI 1529-8809 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD OCT PY 1996 VL 41 IS 4 BP 641 EP 646 DI 10.1097/00005373-199610000-00008 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA VL848 UT WOS:A1996VL84800008 PM 8858022 ER PT J AU Bauer, JJ Sesterhenn, IA Mostofi, FK McLeod, DG Srivastava, S Moul, JW AF Bauer, JJ Sesterhenn, IA Mostofi, FK McLeod, DG Srivastava, S Moul, JW TI Elevated levels of apoptosis regulator proteins p53 and bcl-2 are independent prognostic biomarkers in surgically treated clinically localized prostate cancer SO JOURNAL OF UROLOGY LA English DT Article DE prostatic neoplasms; genes, p53; immunohistochemistry; prostatectomy ID CELL-DEATH; PROGRAMMED DEATH; EXPRESSION; ONCOGENES; TIME; GENE AB Purpose: The tumor suppressor gene (TSG) p53 and the proto-oncogene bcl-2 have been shown to be involved in the regulation of ell growth and apoptosis and have been implicated in hormone refractory prostate cancer (PC) and poor prognosis. The goal of this study was to determine the clinical utility of the presence of p53 and bcl-2 immunohistochemical (IHC) protein in the primary tumor as predictors of disease progression following radical prostatectomy (RP). Materials and Methods: The expression of p53 and bcl-2 was evaluated in archival paraffin-embedded RP specimens from 175 patients followed from 1 to 9 years (mean = 4.6 years) and correlated with stage, grade, race and serologic (PSA) recurrence following surgery. Results: Overexpression of bcl-2 was noted in 47 of 175 (26.9%) patients; these patients had a significantly higher 5-year failure rate than those who did not overexpress bcl-2 (67.0% versus 30.7%). Expression of p53 was noted in 114 of 175 (65.1%) patients with a 5-year failure rate of 51.1% compared with a 5-year failure rate of only 22% in p53 negative patients. When expression rates for p53 and bcl-2 were combined, the 5-year failure rate was 75.3%. Conversely, when both p53 and bcl-2 IHC staining were negative, the 5-year failure rate was 20.4%. Univariate Kaplan-Meier analysis showed a statistically significant difference between p53 and bcl-2 positive and negative patients (p < 0.001). Multivariate Cox Regression Analysis with backward elimination controlling for age, race, stage and grade showed both p53 (p = .0185) and bcl-2 (p = .044) to be independent predictors of disease-free survival. Conclusion: p53 and bcl-2 appear to be important biomarkers that predict recurrence in clinically localized PC after RP. C1 WALTER REED ARMY MED CTR,DEPT SURG,UROL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,DEPT GENITOURINARY PATHOL,WASHINGTON,DC 20306. RP Bauer, JJ (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,CTR PROSTATE DIS RES,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 35 TC 178 Z9 181 U1 0 U2 4 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD OCT PY 1996 VL 156 IS 4 BP 1511 EP 1516 DI 10.1016/S0022-5347(01)65641-6 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA VH857 UT WOS:A1996VH85700084 PM 8808919 ER PT J AU Vogel, P Rivera, VR Pitt, MLM Poli, MA AF Vogel, P Rivera, VR Pitt, MLM Poli, MA TI Comparison of the pulmonary distribution and efficacy of antibodies given to mice by intratracheal instillation or aerosol inhalation SO LABORATORY ANIMAL SCIENCE LA English DT Article ID VIRUS-INFECTION; LUNG; PNEUMONIAE; PARTICLES; RATS AB The respiratory tract is the portal of entry and target organ of many aerosolized toxins and infective agents, and there is increasing need for testing the efficacy of potential therapeutic agents delivered directly into the lungs, Intratracheal instillation and aerosol inhalation are the two methods most often used to introduce drugs, toxins, or infective agents into the respiratory tract of experimental animals, In this study we compared the distribution and efficacy of antibodies given to mice by aerosol inhalation or intratracheal instillation. We determined the pulmonary distribution of these antibodies by immunohistochemistry and observed the distribution and severity of pulmonary lesions that developed after exposure to aerosolized ricin, Although antibodies administered by either method prevented death, we found that instilled antibodies tended to concentrate around terminal airways and often failed to reach peripheral lung fields. Sometimes entire lung lobes were missed by the instillation route, Acute and chronic pulmonary lesions developed in the unprotected areas of instillation-treated lungs, in contrast, aerosolized antibodies covered all pulmonary surfaces and effectively prevented ricin-induced lesions throughout the lungs, Our findings suggest that the aerosol inhalation method may be preferable for evaluating the efficacy of therapeutic agents in the respiratory tract because of the failure of instilled agents to reach and protect peripheral alveoli. C1 USA,MED RES INST INFECT DIS,DIV TOXINOL,FT DETRICK,MD 21702. USA,MED RES INST INFECT DIS,DIV DIAGNOST SYST,FT DETRICK,MD 21702. RP Vogel, P (reprint author), USA,MED RES INST INFECT DIS,DIV PATHOL,FT DETRICK,MD 21702, USA. NR 24 TC 15 Z9 16 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD OCT PY 1996 VL 46 IS 5 BP 516 EP 523 PG 8 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA VN008 UT WOS:A1996VN00800008 PM 8905584 ER PT J AU Merrill, GA Bretthauer, R WrightHicks, J Allen, RC AF Merrill, GA Bretthauer, R WrightHicks, J Allen, RC TI Oxygenation activities of chicken polymorphonuclear leukocytes investigated by selective chemiluminigenic probes SO LABORATORY ANIMAL SCIENCE LA English DT Article ID BACTERICIDAL ACTIVITY; CHEMI-LUMINESCENCE; SUPEROXIDE ANION; NEUTROPHILS; MYELOPEROXIDASE; CHEMILUMINESCENCE; GENERATION; PH AB The redox metabolism of myeloperoxidase-deficient rooster (chicken) polymorphonuclear leukocytes (PMNL) was analyzed by differential chemiluminigenic probes, Chicken complement-opsonified zymosan, a phagocytosable particulate stimulus, and phorbol myristate acetate, a chemical stimulus, were used to activate the PMNL respiratory burst. The two probes used were luminol (5-amino-2,3-dihydro-1,4-phthalazinedione), a general probe of oxidase-peroxidase activities, and lucigenin (dimethylbiacridinium binitrate), a selective probe of oxidase activity, Rooster PMNLs yielded dimethylbiacridinium binitrate-dependent chemiluminescence (CL) comparable to those of myeloperoxidase-containing human PMNLs after stimulation with opsonified zymosan and to a lesser extent with phorbol myristate acetate, However, the luminol-dependent CL of opsonified zymosan or phorbol myristate acetate stimulated rooster PMNLs were approximately two orders of magnitude lower than responses observed with human PMNLs, At physiologic pH, luminol is a highly sensitive, but not specific, probe of myeloperoxidase activity, Rooster erythrocytes yielded no CL with any of the probe-stimulus combinations described, Rooster PMNL viability and oxygen were required for CL, No strong correlation could be drawn between CL responses and eosinophil leukocyte concentration, The major conclusion is that rooster PMNLs, which do not have myeloperoxidase, present a significant and reproducible oxidative burst to chemical and particulate stimuli. Although lacking in peroxidase, rooster PMNLs can still present small. luminol-dependent responses. C1 USA,INST SURG RES,FT SAM HOUSTON,TX. RP Merrill, GA (reprint author), BROOKE ARMY MED CTR,DEPT CLIN INVEST,3851 ROGER BROOKE DR,FT SAM HOUSTON,TX 78234, USA. RI Allen, Robert/B-6529-2008 NR 42 TC 12 Z9 12 U1 2 U2 3 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD OCT PY 1996 VL 46 IS 5 BP 530 EP 538 PG 9 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA VN008 UT WOS:A1996VN00800010 PM 8905586 ER PT J AU Besch, TK Ruble, DL Gibbs, PH Pitt, MLM AF Besch, TK Ruble, DL Gibbs, PH Pitt, MLM TI Steady-state minute volume determination by body-only plethysmography in juvenile rhesus monkeys SO LABORATORY ANIMAL SCIENCE LA English DT Article ID EXPERIMENTAL INHALATION ANTHRAX; VENTILATION AB When one is using nonhuman primates for studying the inhalation of infective or toxic agents, a respiratory minute volume (MV) range of +/-50 ml is desirable to ensure the accurate delivery of calculated doses of the aerosolized agent, When one is working with highly infective or toxic agents, it is desirable to anesthetize the animals and to separate the plethysmograph, used to measure MV, from the aerosol chamber, used to administer agents, in order to minimize decontamination procedures and to maximize safety, In our laboratory the sequential completion of these procedures requires at least 20 min. Therefore it is necessary to find an anesthetic that achieves a +/-50 ml steady-state MV for at least 20 min and that does not change when an animal is transported from one apparatus to another, Using 2.6- to 4.0-kg, 14- to 18-month-old rhesus macaques, we determined that tiletamine/zolazepam induced a steady-state MV of 48+/-17.8 min, beginning 21.5+/-4.7 min after injection of the anesthetic agent, This MV did not significantly change when animals were transported, The use of ketamine and ketamine/acepromazine resulted in a steady-state MV period of 11.5+/-4.5 and 22.0+/-7.9 min respectively. When we compared these findings with previously reported mathematical estimations of MV based on functions of weight or respiratory rate, we further determined that the accurate measurement of MV before each aerosol exposure was critical for calculating inhaled doses of the agent. C1 USA,MED RES INST INFECT DIS,TOXINOL DIV,FT DETRICK,MD 21702. USA,MED RES INST INFECT DIS,DIV VET MED,FT DETRICK,MD 21702. USA,MED RES INST INFECT DIS,DIV BIOMETR & INFOMAT MANAGEMENT,FT DETRICK,MD 21702. NR 17 TC 11 Z9 13 U1 0 U2 1 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD OCT PY 1996 VL 46 IS 5 BP 539 EP 544 PG 6 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA VN008 UT WOS:A1996VN00800011 PM 8905587 ER PT J AU Horosko, S Robert, LL AF Horosko, S Robert, LL TI US Army vector control (preventive medicine) operations during Operation Restore Hope, Somalia SO MILITARY MEDICINE LA English DT Article ID DIARRHEAL-DISEASE AB During the early stages of Operation Restore Hope, three U.S. Army preventive-medicine detachments were deployed to Somalia to counter the disease and non-battle injury threat to deployed forces. The activities of these units are discussed, with an emphasis on the entomology detachment. The preventive medicine (PVNTMED) threat facing deployed forces was considerable, and probably greater than that encountered in any recent operation. This threat is discussed, as are the methods used by the PVNTMED detachments to counter the threat. Vector control and pest management operations of the entomology detachment are highlighted, and how they related to the health and comfort of deployed personnel. These operations ranged from routine mosquito surveillance to large-area vector-control missions using a helicopter-slung pesticide dispersal unit. A variety of ''lessons learned'' are also discussed, focusing on individual and company-level PVNTMED measures. C1 USA,MED DETACHMENT 485TH,PM ENTO,FT POLK,LA 71459. NR 10 TC 9 Z9 9 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1996 VL 161 IS 10 BP 577 EP 581 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA VN509 UT WOS:A1996VN50900002 PM 8918117 ER PT J AU Knapik, JJ Hamlet, MP Thompson, KJ Jones, BH AF Knapik, JJ Hamlet, MP Thompson, KJ Jones, BH TI Influence of boot-sock systems on frequency and severity of foot blisters SO MILITARY MEDICINE LA English DT Article AB This study examined the influence of three types of boot-sock systems on incidence and severity of foot blisters, Participants were 357 men undergoing U.S. Marine recruit training at Parris Island, South Carolina, Each participant was assigned to one of three treatment groups, The first group wore the standard military boot sock consisting of a wool-cotton-nylon-Spandex combination, The second group wore the standard military boot sock with a thin inner or liner sock consisting of polyester, The third group wore a very thick, dense, prototype outer sock consisting of a wool-polypropylene combination over the same liner sock as the second group, Foot blister incidence was lower among participants who wore the the prototype boot sock and liner than among those wearing the standard military sock (40 vs, 69%, p < 0.001) or among subjects wearing the standard military sock with liner (40 vs, 77%, p < 0,001). Foot blisters and cellulitis severe enough to require medical attention occurred with greater frequency in the standard military sock group compared to both the prototype boot-sock group (24 vs, 11%, p = 0.02) and the standard military sock with liner group (24 vs. 9%, p < 0,01); there was no difference between the latter two groups, Blister reduction was most apparent in the early weeks of recruit training. The standard military sock with a polyester liner reduced the incidence of severe blisters, but the dense sock with the polyester liner reduced the overall incidence of blisters as well as the incidence of severe blisters. RP Knapik, JJ (reprint author), USA,RES LAB,HUMAN RES & ENGN DIRECTORATE,ABERDEEN PROVING GROUND,MD 21005, USA. NR 23 TC 28 Z9 28 U1 0 U2 3 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1996 VL 161 IS 10 BP 594 EP 598 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA VN509 UT WOS:A1996VN50900005 PM 8918120 ER PT J AU Ellyson, RE Callahan, C Lee, YTM AF Ellyson, RE Callahan, C Lee, YTM TI Medical care of illegal migrants intercepted on the high sea (Operation Prompt Return) SO MILITARY MEDICINE LA English DT Article AB In July 1995, Operation Prompt Return was mounted to set up a facility on Wake Island in the mid-Pacific to process 158 illegal emigrants and return them to China, The deployed medical team screened and examined the travelers and the ship's crew, Initial major problems consisted of skin rashes, dental diseases, and signs of physical. abuse. Subsequently, urogenital complaints, musculoskeletal pain, and newer cases of scabies were evaluated and treated, Problems relating to planning and provision of medical care to migrants were discussed and solutions were suggested. RP Ellyson, RE (reprint author), C CO,FORWARD SUPPORT BATTAL 325,INFANTRY DIV 25,SCHOFIELD BARRACKS,HI 96757, USA. NR 2 TC 3 Z9 3 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1996 VL 161 IS 10 BP 616 EP 619 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA VN509 UT WOS:A1996VN50900010 PM 8918124 ER PT J AU Broughton, G AF Broughton, G TI Management of the brown recluse spider bite to the glans penis SO MILITARY MEDICINE LA English DT Article ID DAPSONE AB A significant number of people are bitten by the brown recluse spider (BRS) each year, Medical treatment regimens are sometimes unsatisfactory and surgical intervention is often necessary to debride the necrotic wound, This case study reports the treatment given to a 19-year-old active duty United States Army soldier who suffered a BRS bite to the glans penis. This patient received immediate medical attention and was started on intravenously administered diphenhydramine, methylprednisolone, calcium gluconate, and famotidine, Oral dapsone treatment was begun in the emergency room. Within 24 hours after his injury, the patient received his first hyperbaric oxygen treatment, which was continued twice daily for 5 days. Skin necrosis was avoided, the patient did not require any surgical intervention, and he was discharged after 8 days without sequelae. RP Broughton, G (reprint author), BROOKE ARMY MED CTR,DEPT GEN SURG,FT SAM HOUSTON,TX 78234, USA. NR 13 TC 7 Z9 7 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1996 VL 161 IS 10 BP 627 EP 629 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA VN509 UT WOS:A1996VN50900013 PM 8918127 ER PT J AU Meitzler, TJ Karlsen, RE Gerhart, GR Sohn, E Singh, H AF Meitzler, TJ Karlsen, RE Gerhart, GR Sohn, E Singh, H TI Wavelet transforms of cluttered images and their application to computing the probability of detection SO OPTICAL ENGINEERING LA English DT Article DE wavelets; target acquisition; theory of signal detection; clutter metrics; infrared images AB Wavelet transforms are currently being used for a number of applications such as cue feature and noise extraction from images and acoustic signals. This work describes and applies an algorithm that uses wavelets for finding the clutter in infrared (IR) and visual images. Once the clutter is found, the probability of detection (P-d) is calculated. Tidhar's and Rotman's probability of edge metric (POE) is extended to encompass the wavelet methodology for multiscale clutter metrics in IR images. (C) 1996 society of Photo-Optical Instrumentation Engineers. C1 WAYNE STATE UNIV,DEPT ELECT & COMP ENGN,DETROIT,MI 48092. RP Meitzler, TJ (reprint author), USA,TANK AUTOMOT COMMAND,SURVIVABIL TECHNOL CTR,WARREN,MI 48397, USA. RI Meitzler, Thomas/D-1065-2017 NR 17 TC 16 Z9 18 U1 0 U2 0 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD OCT PY 1996 VL 35 IS 10 BP 3019 EP 3025 DI 10.1117/1.600987 PG 7 WC Optics SC Optics GA VM380 UT WOS:A1996VM38000036 ER PT J AU Gerhart, GR Bednarz, EL Meitzler, TJ Sohn, E Karlsen, RE AF Gerhart, GR Bednarz, EL Meitzler, TJ Sohn, E Karlsen, RE TI Target acquisition methodology for visual and infrared imaging sensors SO OPTICAL ENGINEERING LA English DT Article DE target acquisition; detection models; sensor performance; infrared sensors; human perception; countermeasures ID PERFORMANCE; CLUTTER AB Today the great majority of target acquisition models within the Department of Defense (DoD) originate from two primary sources of empirical human observer data: the Blackwell-Tiffany visual perception experiments begun in World War II and the Army Night Vision Electrooptic Sensors Directorate (NVESD) field test trials with military observers. An extensive sensitivity analysis that compares the performance of several DoD acquisition models derived from these two extensive sets of data was carried out, A comprehensive analysis of each method and a detailed comparison of these different methodologies shows that they are in remarkably good agreement throughout their ranges of applicability. The authors show when the various modeling methodologies are applicable for a variety of military sensor and countermeasure scenarios. (C) 1996 Society of Photo-Optical Instrumentation Engineers. C1 USA,CTR ENGN,WARREN,MI 48397. RP Gerhart, GR (reprint author), USA,TANK AUTOMOT & ARMANENTS COMMAND,TANK AUTOMOT RES DEV,AMST-TR-R,MS 263,WARREN,MI 48397, USA. RI Meitzler, Thomas/D-1065-2017 NR 23 TC 14 Z9 15 U1 1 U2 2 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD OCT PY 1996 VL 35 IS 10 BP 3026 EP 3036 DI 10.1117/1.600953 PG 11 WC Optics SC Optics GA VM380 UT WOS:A1996VM38000037 ER PT J AU Doukas, WC Christensen, KP AF Doukas, WC Christensen, KP TI Surgical treatment of symptomatic, posttraumatic heterotopic ossification in the adductor mass off the pubic arch SO ORTHOPEDICS LA English DT Article ID MYOSITIS-OSSIFICANS C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. NR 13 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD OCT PY 1996 VL 19 IS 10 BP 893 EP 895 PG 3 WC Orthopedics SC Orthopedics GA VN774 UT WOS:A1996VN77400017 PM 8905864 ER PT J AU Tran, LP Grundfast, KM Selesnick, SH AF Tran, LP Grundfast, KM Selesnick, SH TI Benign lesions of the external auditory canal SO OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA LA English DT Article ID LANGERHANS CELL HISTIOCYTOSIS; FIBROUS DYSPLASIA; TEMPORAL BONE; EOSINOPHILIC GRANULOMA; POSTERIOR DISLOCATION; MANDIBULAR CONDYLE; ECCRINE CYLINDROMA; OTOLOGIC SURGERY; FRACTURE; TUMORS AB Although histologically benign, lesions discussed in this review of benign lesions of the external auditory canal can, if underestimated, result in significant local tissue destruction. Accurate diagnosis will not only exclude malignancies but will also identify benign diseases with particularly insidious and locally aggressive growth patterns. Discussed in this article are a few common lesions and several interesting, but uncommon, entities that may be encountered. Radiologic and histologic examples supplement descriptions in the article. C1 CHILDRENS NATL MED CTR,DEPT OTOLARYNGOL,WASHINGTON,DC 20010. GEORGE WASHINGTON UNIV,SCH MED,WASHINGTON,DC. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. CORNELL UNIV,COLL MED,NEW YORK HOSP,NEW YORK,NY. MANHATTAN EYE EAR & THROAT HOSP,NEW YORK,NY 10021. NR 43 TC 9 Z9 10 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0030-6665 J9 OTOLARYNG CLIN N AM JI Otolaryngol. Clin. N. Am. PD OCT PY 1996 VL 29 IS 5 BP 807 EP & PG 20 WC Otorhinolaryngology SC Otorhinolaryngology GA VK808 UT WOS:A1996VK80800008 PM 8893218 ER PT J AU Ender, PT Dooley, DP Moore, RH AF Ender, PT Dooley, DP Moore, RH TI Vascular catheter-related Comamonas acidovorans bacteremia managed with preservation of the catheter SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE Comamonas acidovorans; vascular catheter infection; bacteremia ID INFECTIONS C1 BROOKE ARMY MED CTR,DEPT PEDIAT,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DEPT INFECT DIS,FT SAM HOUSTON,TX 78234. RP Ender, PT (reprint author), WILFORD HALL USAF MED CTR,DEPT INFECT DIS,PSMI,2200 BERQUIST DR STE 1,LACKLAND AFB,TX 78236, USA. NR 11 TC 16 Z9 16 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD OCT PY 1996 VL 15 IS 10 BP 918 EP 920 DI 10.1097/00006454-199610000-00021 PG 3 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA VL708 UT WOS:A1996VL70800019 PM 8895931 ER PT J AU Lunardini, VJ AF Lunardini, VJ TI Climatic warming and the degradation of warm permafrost SO PERMAFROST AND PERIGLACIAL PROCESSES LA English DT Article; Proceedings Paper CT IPA Workshop on Frozen Ground: Current Understanding and Ability to Monitor Change CY DEC 09-11, 1995 CL HANOVER, NH SP IPA DE climate change; permafrost degradation; modelling ID THICKNESS AB Permafrost - a widespread constituent of the terrestrial environment - by definition is dependent upon the ambient temperature for its existence and properties. Thus, it is very sensitive to climatic changes. Simple relations based upon conductive heat transfer, with thawing and geothermal heat flow, are presented to predict the transient effects of surface temperature increases on the thermal state of permafrost. The results indicate that, based on the usual global warming scenarios, relatively small amounts of permafrost will disappear within 50-100 years. This is specifically shown for the most thermally sensitive cases, that is, warm or relict permafrost. RP Lunardini, VJ (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 22 TC 47 Z9 58 U1 3 U2 11 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 1045-6740 J9 PERMAFROST PERIGLAC JI Permafrost Periglacial Process. PD OCT-DEC PY 1996 VL 7 IS 4 BP 311 EP 320 DI 10.1002/(SICI)1099-1530(199610)7:4<311::AID-PPP234>3.0.CO;2-H PG 10 WC Geography, Physical; Geology SC Physical Geography; Geology GA WQ806 UT WOS:A1996WQ80600003 ER PT J AU Crenshaw, ME AF Crenshaw, ME TI Quasiadiabatic approximation for a dense collection of two-level atoms SO PHYSICAL REVIEW A LA English DT Article ID ADIABATIC-FOLLOWING APPROXIMATION; 2-LEVEL ATOMS; OPTICAL BISTABILITY; RESONANT MEDIUM; PROPAGATION; PULSES; LIGHT; REFLECTION; EMISSION; SYSTEMS AB In dense media, the Lorentz local-field condition results in a generalization of the usual semiclassical Maxwell-Bloch formulation for two-level atoms in which the optical Bloch equations are recast in terms of macroscopic spatially averaged atomic variables. We derive an adiabaticlike, or stationary, approximation for the generalized Bloch equations in the ultratransient limit and establish validity criteria. The significance of this quasiadiabatic approximation is that a point response solution of the generalized Bloch equations is obtained in terms of the field strength, thereby allowing the atomic response to be expressed as a nonlinear susceptibility that can be used to predict and analyze propagation effects in dense media. The quasiadiabatic approximation is quite general, allowing for a combination of detuning, chirping, and a variety of local-field and mean-field effects. It spans the range from cases for which local-field effects can be neglected, as in the usual adiabatic approximation, to cases in which local-field effects cause a large inversion-dependent frequency renormalization. The approximation is used to interpret previous numerical results for the resonant interaction of ultrashort pulses with dense media and it is shown that dense media can exhibit behavior analogous to adiabatic following and adiabatic inversion. The nonlinear index of refraction in the quasiadiabatic limit is purely real for large detunings. However, at and near resonance, the nonlinear index is purely imaginary. The imaginary index relates to coherent reflectivity arising from the reaction field of the cooperating atoms, rather than absorption, and transmission and reflection coefficients for thin films are derived. In the intermediate range of detunings, the intensity-dependent index of refraction can undergo a phase transition due solely to the variation of the field intensity during excitation by an ultrashort pulse. Propagation effects are investigated using a finite-difference time-domain method to integrate the generalized Bloch-Maxwell equations and the results of the numerical simulations are analyzed in the context of the nonlinear index of refraction obtained using the quasiadiabatic approximation. RP Crenshaw, ME (reprint author), USA, MISSILE COMMAND,CTR RES DEV & ENGN, WEAP SCI DIRECTORATE,ST, WS, RD, REDSTONE ARSENAL, AL 35898 USA. NR 42 TC 18 Z9 18 U1 0 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD OCT PY 1996 VL 54 IS 4 BP 3559 EP 3575 DI 10.1103/PhysRevA.54.3559 PG 17 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA VM255 UT WOS:A1996VM25500133 ER PT J AU Rizvi, SA Wang, LC Nasrabadi, NM AF Rizvi, SA Wang, LC Nasrabadi, NM TI Neural network architectures for vector prediction SO PROCEEDINGS OF THE IEEE LA English DT Article ID QUANTIZATION AB A vector predictor is an integral part of a predictive vector quantization (PVQ) coding scheme. However, the performance of a classical linear vector predictor is limited by its ability to exploit only the linear correlation between the blocks. Furthermore, its performance deteriorates as the vector dimension (block size) is increased, especially when predicting blocks that contain edge information. However, a nonlinear predictor exploits the higher-order correlations among the neighboring blocks, and can predict edge blocks with increased accuracy. Because the conventional techniques for designing a nonlinear predictor are extremely complex and suboptimal due to the absence of a suitable model for the source data, it is necessary to investigate new procedures in order to design nonlinear vector predictors. In this paper, we have investigated several neural network architectures that can be used to implement a nonlinear vector predictor, including the Multilayer Perceptron, the Functional Link network, and the Radial Basis Function network. We also evaluated and compared the performance of these neural network predictors with that of a linear vector predictor. Our experimental results show that a neural network predictor can predict the blocks containing edges with a higher accuracy than a linear predictor. However, the performance of a neural network predictor is comparable to that of a linear predictor for predicting the stationary and shade blocks. C1 USA,RES LAB,DEPT ARMY,FT BELVOIR,VA 22060. RP Rizvi, SA (reprint author), SUNY BUFFALO,DEPT ELECT & COMP ENGN,AMHERST,NY 14260, USA. NR 16 TC 12 Z9 14 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9219 J9 P IEEE JI Proc. IEEE PD OCT PY 1996 VL 84 IS 10 BP 1513 EP 1528 DI 10.1109/5.537115 PG 16 WC Engineering, Electrical & Electronic SC Engineering GA VK624 UT WOS:A1996VK62400012 ER PT J AU Labbate, LA Benedek, DM AF Labbate, LA Benedek, DM TI Bedside stuffed animals and borderline personality SO PSYCHOLOGICAL REPORTS LA English DT Article AB We explored the relationship between psychiatric diagnosis and the presence of stuffed animals at the bedside in a population of adult female psychiatric inpatients. One of the authors made approximately weekly surveys of the wardrooms of adult psychiatric inpatients over twelve months for the presence of displayed scuffed animals. The observer was blind to the diagnosis of 80% of the patients, and the study or its hypothesis was not known to other physicians. The discharge diagnoses of patients displaying stuffed animals were recorded and compared with those of the ward population in general. Among 36 female patients who displayed stuffed animals in their rooms, Borderline Personality Disorder was diagnosed in 22 (61%) of these patients. Of 447 adult female patients admitted to the same unit over the same period, only 17% were noted to be diagnosed Borderline Personality Disorder. Stuffed animals as a bedside clinical due may suggest evaluation for Borderline Personality Disorder. C1 WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20307. RP Labbate, LA (reprint author), VET ADM MED CTR,DEPT PSYCHIAT,CHARLESTON,SC 29407, USA. NR 4 TC 4 Z9 4 U1 0 U2 2 PU PSYCHOLOGICAL REPORTS PI MISSOULA PA P O BOX 9229, MISSOULA, MT 59807 SN 0033-2941 J9 PSYCHOL REP JI Psychol. Rep. PD OCT PY 1996 VL 79 IS 2 BP 624 EP 626 PG 3 WC Psychology, Multidisciplinary SC Psychology GA VM337 UT WOS:A1996VM33700050 PM 8909090 ER PT J AU Nogami, GY AF Nogami, GY TI Eight points for more useful surveys SO QUALITY PROGRESS LA English DT Article RP Nogami, GY (reprint author), USA,WAR COLL,CARLISLE,PA, USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC QUALITY CONTROL-ASQC PI MILWAUKEE PA ASQC MEMBERSHIP MANAGER 611 E. WISCONSIN AVENUE, MILWAUKEE, WI 53202 SN 0033-524X J9 QUAL PROG JI Qual. Prog. PD OCT PY 1996 VL 29 IS 10 BP 93 EP 96 PG 4 WC Engineering, Multidisciplinary; Engineering, Industrial; Management; Operations Research & Management Science SC Engineering; Business & Economics; Operations Research & Management Science GA VK622 UT WOS:A1996VK62200026 ER PT J AU Balakirsky, SB Chellappa, R AF Balakirsky, SB Chellappa, R TI Performance characterization of image stabilization algorithms SO REAL-TIME IMAGING LA English DT Article AB This paper compares three image stabilization algorithms when used as preprocessors for a target tracking application. These algorithms vary in computational complexity, accuracy, and ability. Algorithm 1 is capable of only pixel-level realignment of imagery, while Algorithms 2 and 3 are capable of full subpixel stabilization with respect to translation, rotation, and scale. The algorithms are evaluated on their performance in the stabilization of one synthetic forward looking infrared (FLIR) data set and two real FLIR imagery data sets. The evaluation tools incorporated include mean absolute error of the output data set and the overall performance of an automatic target acquisition system (developed at the Army Research Laboratory) that uses the algorithms as a front end preprocessor. We found that for this tracking application, extremely accurate subpixel stabilization was a requirement for proper operation. We also found that in this application, Algorithm 3 performed significantly better than the other two algorithms. (C) 1996 Academic Press Limited C1 UNIV MARYLAND,COLLEGE PK,MD 20742. RP Balakirsky, SB (reprint author), USA,RES LAB,ADELPHI,MD 20743, USA. NR 23 TC 13 Z9 15 U1 1 U2 3 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 1077-2014 J9 REAL-TIME IMAGING JI Real-Time Imaging PD OCT PY 1996 VL 2 IS 5 BP 297 EP 313 DI 10.1006/rtim.1996.0031 PG 17 WC Computer Science, Artificial Intelligence; Computer Science, Software Engineering; Computer Science, Theory & Methods SC Computer Science GA VR711 UT WOS:A1996VR71100004 ER PT J AU Price, DC AF Price, DC TI Chemiluminescent substrates for detection of restriction fragment length polymorphism SO SCIENCE & JUSTICE LA English DT Article DE forensic science; DNA; RFLP; chemiluminescent substrates; HaeIII ID DNA PROBES; ALKALINE-PHOSPHATASE; LUMINESCENT AB Five new enzyme-triggered dioxetane substrates were evaluated for restriction fragment length polymorphism (RFLP) analysis of HaeIII-restricted DNA. Of these, one substrate designated CDP-Star provided unsurpassed sensitivity within one working day without the presence of an enhancer. Far greater sensitivity was obtained from chemiluminescent detection of DNA on MSI neutral membranes than the sensitivity obtained from six day film exposures of P-32 labelled insert probes on PALL B membranes, including the detection of most low molecular weight alleles. For nylon membranes better suited for alkaline phosphatase-triggered chemiluminescent detection of DNA, high salt/neutral pH southern transfer conditions were better than alkaline southern transfer conditions. RP Price, DC (reprint author), USA,CRIMINAL INVEST LAB,FT GILLEN,FOREST PK,GA 30050, USA. NR 12 TC 5 Z9 5 U1 0 U2 2 PU FORENSIC SCIENCE SOC PI HARROGATEKSHIRE PA CLARK HOUSE, 18A MOUNT PARADE, HARROGATEKSHIRE, N YORKSHIRE, ENGLAND HG1 1BX SN 1355-0306 J9 SCI JUSTICE JI Sci. Justice PD OCT-DEC PY 1996 VL 36 IS 4 BP 275 EP 282 DI 10.1016/S1355-0306(96)72614-X PG 8 WC Medicine, Legal; Pathology SC Legal Medicine; Pathology GA VT013 UT WOS:A1996VT01300010 PM 8921749 ER PT J AU Hess, JR AF Hess, JR TI Blood substitutes SO SEMINARS IN HEMATOLOGY LA English DT Article ID STROMA-FREE HEMOGLOBIN; CELL-FREE HEMOGLOBIN; PYRIDOXYLATED HEMOGLOBIN; HEMORRHAGIC-SHOCK; FLUOSOL-DA; RESUSCITATION; OXYGEN; TOXICITY; ALPHA; ENDOTOXIN RP Hess, JR (reprint author), WALTER REED ARMY INST RES, BLOOD RES DETACHMENT, WASHINGTON, DC 20307 USA. NR 76 TC 39 Z9 39 U1 1 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0037-1963 J9 SEMIN HEMATOL JI Semin. Hematol. PD OCT PY 1996 VL 33 IS 4 BP 369 EP 378 PG 10 WC Hematology SC Hematology GA VQ194 UT WOS:A1996VQ19400009 PM 8916309 ER PT J AU McGuire, WP Hoskins, WJ Brady, MF Kucera, PR Partridge, EE Look, KY ClarkePearson, DL Davidson, M AF McGuire, WP Hoskins, WJ Brady, MF Kucera, PR Partridge, EE Look, KY ClarkePearson, DL Davidson, M TI Cyclophosphamide and cisplatin versus paclitaxel and cisplatin: A phase III randomized trial in patients with suboptimal stage III/IV ovarian cancer (from the Gynecologic Oncology Group) SO SEMINARS IN ONCOLOGY LA English DT Article ID COMBINATION CHEMOTHERAPY; FOLLOW-UP; CARCINOMA; TAXOL; DOXORUBICIN; LONG C1 EMORY UNIV,DEPT MED,ATLANTA,GA 30322. MEM SLOAN KETTERING CANC CTR,DEPT SURG,GYNECOL SERV,NEW YORK,NY 10021. CORNELL UNIV,COLL MED,DEPT OBSTET & GYNECOL,NEW YORK,NY. ROSWELL PK CANC INST,GYNECOL ONCOL GRP,STAT OFF,BUFFALO,NY. OREGON HLTH SCI UNIV,DEPT OBSTET & GYNECOL,DIV GYNECOL ONCOL,PORTLAND,OR 97201. UNIV ALABAMA,DEPT OBSTET & GYNECOL,DIV GYNECOL ONCOL,BIRMINGHAM,AL 35294. INDIANA UNIV,SCH MED,DIV OBSTET & GYNECOL,INDIANAPOLIS,IN. DUKE UNIV,SCH MED,DEPT OBSTET & GYNECOL,DIV GYNECOL ONCOL,DURHAM,NC 27706. WALTER REED ARMY MED CTR,DEPT PATHOL & AREA LAB SCI,WASHINGTON,DC 20307. RP McGuire, WP (reprint author), GYNECOL ONCOL GRP,ADM OFF,SUITE 1945,1234 MARKET ST,PHILADELPHIA,PA 19107, USA. NR 24 TC 95 Z9 96 U1 1 U2 4 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0093-7754 J9 SEMIN ONCOL JI Semin. Oncol. PD OCT PY 1996 VL 23 IS 5 SU 12 BP 40 EP 47 PG 8 WC Oncology SC Oncology GA VU006 UT WOS:A1996VU00600009 PM 8941409 ER PT J AU Kim, H Lepler, L Daniels, A Phillips, Y AF Kim, H Lepler, L Daniels, A Phillips, Y TI alpha(1)-Antitrypsin deficiency and idiopathic pulmonary fibrosis in a family SO SOUTHERN MEDICAL JOURNAL LA English DT Article ID ALPHA-1-ANTITRYPSIN DEFICIENCY; ALVEOLITIS; DISEASE; INJURY AB Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease of unknown etiology with an estimated prevalence of 3 to 5 per 100,000. We describe a patient with a family history of both IPF and alpha(1)-antitrypsin (AAT) deficiency The patient had a 6-month history of worsening dyspnea when first seen, and he later died of multisystem organ failure and recalcitrant hypoxemia, He had IPF and AAT deficiency, with the phenotype PiSZ. His father and younger brother died of respiratory failure due to IPF. Other family members are heterozygous for AAT deficiency. A variety of inflammatory diseases have been associated with AAT deficiency, and an association between heterozygous AAT deficiency and IPF has been reported in the literature, Most current theories on the pathogenesis of IPF suggest an aberrant inflammatory response to some stimulus, This family cluster and another reported in the literature suggest that AAT deficiency may be a factor predisposing to inflammatory lung disease manifested by interstitial fibrosis. C1 WALTER REED ARMY MED CTR,DEPT INTERNAL MED,WASHINGTON,DC 20307. NR 13 TC 2 Z9 2 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD OCT PY 1996 VL 89 IS 10 BP 1008 EP 1010 DI 10.1097/00007611-199610000-00017 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA VM626 UT WOS:A1996VM62600017 PM 8865799 ER PT J AU Fountzoulas, CG Gonzales, A Hirvonen, JK Sartwell, BD Lancaster, F AF Fountzoulas, CG Gonzales, A Hirvonen, JK Sartwell, BD Lancaster, F TI Corpus Christi Army Depot ion implanter: Capabilities and capacities for industrial applications SO SURFACE & COATINGS TECHNOLOGY LA English DT Article; Proceedings Paper CT 9th International Conference on Surface Modification of Metals by Ion Beams (SMMIB 95) CY SEP 04-08, 1995 CL SAN SEBASTIAN, SPAIN SP INASMET DE ion implanter; capabilities; capacities; industrial ID WEAR AB The features and initial results obtained from using a large-scale production, non-mass-analyzed ion implanter installed at the Corpus Christi Army Depot (CCAD) in September 1994 will be discussed, The ISC-5000 ion implanter (Implant Sciences Corporation, Wakefield, MA) is the largest non-semiconductor implanter in the USA. This machine has been devoted to the treatment of cutting tools and other critical components of interest to the US Army. The ion implanter is a fully automated user-friendly machine. Its large-diameter (0.762 m) target platen allows the simultaneous processing of up to 500 tooling inserts of various shapes and sizes in one batch, The following types of cutting tool and material have been ion implanted with nitrogen: (1) both TiN coated and uncoated cutting tools of WC (Co) and high speed steel, which include cutting tools such as inserts, reamers, end mills and taps, and (2) Cr-plated specimens of copper-based material. The coated WC cutting tools were tested for the machining of high nickel alloys and show an average of 30% tool life improvement over non-ion-implanted TiN inserts. This performance improvement in conjunction with the large tool-volume-processing capacity make the CCAD machine economical to operate and have provided actual hardware demonstrations of the benefits of the ion implantation process. C1 USA,CORPUS CHRISTI DEPOT,CORPUS CHRISTI,TX 78419. USN,RES LAB,WASHINGTON,DC 20375. NATL DEF CTR ENVIRONM EXCELLENCE,JOHNSTOWN,PA 15904. RP Fountzoulas, CG (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 9 TC 6 Z9 6 U1 0 U2 1 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD OCT PY 1996 VL 84 IS 1-3 BP 574 EP 578 DI 10.1016/S0257-8972(96)02843-5 PG 5 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA VK485 UT WOS:A1996VK48500044 ER PT J AU Kiang, JG Wang, XD Ding, XZ Gist, ID Smallridge, RC AF Kiang, JG Wang, XD Ding, XZ Gist, ID Smallridge, RC TI Heat shock inhibits the hypoxia-induced effects on iodide uptake and signal transduction and enhances cell survival in rat thyroid FRTL-5 cells SO THYROID LA English DT Article ID PROTEIN-KINASE-C; CYTOSOLIC-FREE CALCIUM; TRANSPORT; INJURY; THYROTROPIN; ACTIVATION; EXPRESSION; INDUCTION; INCREASE; DAMAGE AB Chronic hypoxia inhibits rat thyroid function in vivo. To determine possible mechanisms, we studied the effect of hypoxia on iodide uptake, the involvement of second messengers, and cell membrane permeability in rat thyroid FRTL-5 cells. Since sublethal heat stress protects tissues from ischemia, we also determined effects of heat stress. The initial rate of iodide uptake in untreated cells was between 12.98 and 15.28 pmol/mu g DNA/min. Hypoxia (5% O-2) increased the rate of uptake in a time-dependent manner. Heating cells at 45 degrees C for 15 min (heat shock) prior to exposure to hypoxia for 3 days inhibited the increase in the initial rate of I-uptake. Using fura-2, we found that the resting [Ca2+](i) in suspended FRTL-5 cells was 65 +/- 7 nM (n = 16). [Ca2+](i) was not increased in cells exposed to hypoxia for 1 day, while a 3-day exposure increased [Ca2+](i) by 43 +/- 4% (P < 0.05); no additional increase occurred after 7 days of exposure. When cells were heated prior to hypoxia exposure for 3 days, the hypoxia-induced increase in [Ca2+](i) did not occur. Similar observations were found with inositol trisphosphates (InsP(3)). Exposure of cells to hypoxia for 3 days increased InsP(3) from 0.08 +/- 0.02 (n = 5) to 0.32 +/- 0.04% total cpm (n = 5, P < 0.05), but sublethal heating of cells prior to hypoxia exposure prevented the increase. Three-day hypoxia increased PKC activity in the membrane fraction (from 67 +/- 7 to 86 +/- 4% of total activity, p < 0.05), and heat shock inhibited these changes also. Immunoblots showed that hypoxia treatment alone and heat shock plus hypoxia resulted in the translocation of PKC-alpha, -delta, -epsilon, and -zeta isoforms, whereas heat shock alone translocated only PKC-beta I, -beta II, and -zeta. Cell membrane integrity was assayed by trypan blue exclusion. Hypoxia alone for 3 days did not affect membrane permeability, but only 49 +/- 3% of cells excluded trypan blue when a 3-day hypoxia exposure was followed by a 6 h reoxygenation. Heat shock prior to hypoxia and reoxygenation protected cell membrane function. Heat shock also induced heat shock protein 70 kDa (HSP-70) synthesis at the transcriptional level. Results suggest that heat shock protects FRTL-5 cells from hypoxic injury, perhaps by inhibiting the initial rate of iodide uptake and second messengers. It is likely that HSP-70 plays an essential role in the process of protection. RP Kiang, JG (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT CLIN PHYSIOL,DIV MED,WASHINGTON,DC 20307, USA. NR 50 TC 23 Z9 25 U1 0 U2 1 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 1050-7256 J9 THYROID JI Thyroid PD OCT PY 1996 VL 6 IS 5 BP 475 EP 483 DI 10.1089/thy.1996.6.475 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA VT667 UT WOS:A1996VT66700018 PM 8936675 ER PT J AU Hess, JR Reiss, RF AF Hess, JR Reiss, RF TI Resuscitation and the limited utility of the present generation of blood substitutes SO TRANSFUSION MEDICINE REVIEWS LA English DT Article ID CROSS-LINKED HEMOGLOBIN; STROMA-FREE HEMOGLOBIN; CELL-FREE HEMOGLOBIN; HEMORRHAGIC-SHOCK; EXCHANGE-TRANSFUSION; WHOLE-BLOOD; FLUOSOL-DA; ALPHA; PERFLUOROCARBONS; EMULSIONS C1 COLUMBIA PRESBYTERIAN MED CTR, DIV LAB HEMATOL & TRANSFUS MED, NEW YORK, NY 10032 USA. RP Hess, JR (reprint author), WALTER REED ARMY INST RES, BLOOD RES DETACHMENT, WASHINGTON, DC 20307 USA. NR 68 TC 24 Z9 24 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0887-7963 J9 TRANSFUS MED REV JI Transf. Med. Rev. PD OCT PY 1996 VL 10 IS 4 BP 276 EP 285 DI 10.1016/S0887-7963(96)80003-4 PG 10 WC Hematology SC Hematology GA VM071 UT WOS:A1996VM07100003 PM 8899956 ER PT J AU Thompson, IM AF Thompson, IM TI Recommendations of the first Michigan conference on prostate cancer - Comment SO UROLOGY LA English DT Editorial Material RP Thompson, IM (reprint author), BROOKE ARMY MED CTR,DEPT SURG,SAN ANTONIO,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD OCT PY 1996 VL 48 IS 4 BP 533 EP 534 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA VP210 UT WOS:A1996VP21000002 ER PT J AU Fernandez, FM Conner, ME Parwani, AV Todhunter, D Smith, KL Crawford, SE Estes, MK Saif, LJ AF Fernandez, FM Conner, ME Parwani, AV Todhunter, D Smith, KL Crawford, SE Estes, MK Saif, LJ TI Isotype-specific antibody responses to rotavirus and virus proteins in cows inoculated with subunit vaccines composed of recombinant SA11 rotavirus core-like particles (CLP) or virus-like particles (VLP) SO VACCINE LA English DT Article DE recombinant rotavirus subunit vaccines; core-like particles; virus-like particles; bovine antibodies to rotavirus in colostrum; milk ID OIL-ADJUVANTED ROTAVIRUS; ESCHERICHIA-COLI VACCINE; BOVINE ROTAVIRUS; PASSIVE-IMMUNITY; MONOCLONAL-ANTIBODIES; CALF DIARRHEA; CALVES; INFECTIONS; EFFICACY; BEEF AB The isotype antibody responses to bovine IND P-5, G6 and simian SA11 P-2, G3 rotavirus and SA11 rotavirus proteins (VP4, VP6 and VP7) in serum, colostrum and milk were analysed by ELISA in three groups of vaccinated cows and nonvaccinated controls. Pregnant cows were vaccinated intramuscularly and intramammarily with recombinant baculovirus-expressed SA11 rotavirus VLP (triple-layered virus-like particles containing rotavirus VP2, VP4, VP6 and VP7), CLP (double-layered core-like particles containing rotavirus VP2 and VP6); or inactivated SA11 rotavirus, respectively. Rotavirus antigen titers were highest (30-200-fold) in ELISA in the VLP vaccine compared to the inactivated SA11 vaccine. The IgG1, IgG2 and IgM geometric mean antibody titers (GMT) to rotavirus (titers to bovine rotavirus vs SA11 rotavirus did not differ significantly for any isotype or group) and the IgG2 GMT to VP6 in serum at calving in the vaccinated groups were significantly (P < 0.05) higher than in the control group. In colostrum, IgG1 and IgA rotavirus antibody titers were significantly elevated for VLP (IgG1 GMT 832225, IgA GMT 16384), CLP (IgG1 GMT 660561, IgA GMT 10321) and SA11 (IgG1 GMT 131072; IgA GMT 1448) vaccinated cows compared to control cows (IgG1 GMT 11585, IgA GMT 45). The IgG1 and IgA GMT to rotavirus were significantly elevated (6-100-fold) in milk of VLP and CLP vaccinated cows compared to SA11 vaccinated or control cows. The isotype antibody responses to VP6 in serum, colostrum and milk paralleled the responses to rotavirus, but titers were similar to 2-10-fold lower. Only cows vaccinated with VLP had significantly enhanced serum, colostral and milk antibody titers to rotavirus VP4 and VP7. These results demonstrate that rotavirus antibody titers in serum, colostrum and milk are significantly enhanced by use of non-infectious VLP, CLP and inactivated SA11 rotavirus vaccines, but the VLP or CLP vaccines induced the highest antibody responses, corresponding to their higher rotavirus antigen titers measured by ELISA. Copyright (C) 1996 Elsevier Science Ltd. C1 OHIO STATE UNIV,OHIO AGR RES & DEV CTR,FOOD ANIM HLTH RES PROGRAM,COLUMBUS,OH 43210. OHIO STATE UNIV,OHIO AGR RES & DEV CTR,DEPT ANIM SCI,COLUMBUS,OH 43210. INTA,CICV,INST VIROL,CASTELAR,ARGENTINA. BAYLOR COLL MED,DIV MOL VIROL,HOUSTON,TX 77030. USA,MED CTR,HOUSTON,TX 77030. NR 35 TC 21 Z9 22 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD OCT PY 1996 VL 14 IS 14 BP 1303 EP 1312 DI 10.1016/S0264-410X(96)00065-5 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA VZ671 UT WOS:A1996VZ67100002 PM 9004438 ER PT J AU Reed, WW Byrd, GS Gates, RH Howard, RS Weaver, MJ AF Reed, WW Byrd, GS Gates, RH Howard, RS Weaver, MJ TI Sputum Gram's stain in community-acquired pneumococcal pneumonia - A meta-analysis SO WESTERN JOURNAL OF MEDICINE LA English DT Article ID EVALUATING DIAGNOSTIC-TESTS; ETIOLOGICAL DIAGNOSIS; BACTERIAL PNEUMONIA; CULTURE; MANAGEMENT; INFECTION; NONVALUE AB The usefulness of the sputum Cram's stain is controversial. This meta-analysis was designed to evaluate the sensitivity and specificity of the sputum Cram's stain in community-acquired pneumococcal pneumonia, Using a predetermined protocol, articles were discovered through a MEDLINE search (1966 to 1993) and the examination of bibliographies and were graded for quality by three blinded reviewers. Information on the reference standard, blinding, stain interpreter, control for antibiotic use, and definition of a positive test was collected, We found 12 articles containing 17 test characteristics to evaluate. The number of patients in each study ranged from 16 to 404. Sputum culture was the most common reference standard (10 of 17 estimations). Sensitivity ranged from 15% to 100% and specificity from 11% to 100%. Test characteristics varied markedly among studies and appeared related partly to the test interpreter. The sputum Cram's stain may yield misleading results in community-acquired pneumonia, as its sensitivity and specificity vary substantially in different settings. A practitioner electing to use the study should be well trained and use a specific definition for a positive test. C1 FITZSIMONS ARMY MED CTR,DEPT MED,AURORA,CO 80045. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 46 TC 58 Z9 65 U1 0 U2 0 PU CALIFORNIA PHYSICIAN MAGAZINE PI SAN FRANCISCO PA C/O DONNA TAYLOR, EDITOR, PO BOX 7690, SAN FRANCISCO, CA 94102-7690 SN 0093-0415 J9 WESTERN J MED JI West. J. Med. PD OCT PY 1996 VL 165 IS 4 BP 197 EP 204 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA VU111 UT WOS:A1996VU11100002 PM 8987424 ER PT J AU MacKenzie, JD Abernathy, CR Pearton, SJ Hommerich, U Wu, X Schwartz, RN Wilson, RG Zavada, JM AF MacKenzie, JD Abernathy, CR Pearton, SJ Hommerich, U Wu, X Schwartz, RN Wilson, RG Zavada, JM TI Er doping of AlN during growth by metalorganic molecular beam epitaxy SO APPLIED PHYSICS LETTERS LA English DT Article ID LUMINESCENCE; SEMICONDUCTORS; SILICON; ERBIUM AB The doping of AlN during growth by metalorganic molecular beam epitaxy with an Er effusion source has resulted in AlN:Er films exhibiting strong room-temperature 1.54 mu m photoluminescence (PL). The luminescence detected in the AlN:Er grown during this study was orders of magnitude greater in intensity than that from ion-implanted samples and represents the first demonstration of strong emission from rare-earth doped, epitaxial group III nitrides. Secondary ion mass spectroscopy was used to verify a dynamic range for this doping technique of 3X10(17)-2X10(21) Er cm(-3) with varying effusion cell temperature. The effects of growth temperature on Er incorporation and segregation behavior were also determined. PL studies, including room-temperature and thermal quenching experiments, were conducted. (C) 1996 American Institute of Physics. C1 HAMPTON UNIV, DEPT PHYS, RES CTR OPT PHYS, HAMPTON, VA 23668 USA. HUGHES RES LABS, MALIBU, CA 90265 USA. USA, RES OFF, RES TRIANGLE PK, NC 27709 USA. RP UNIV FLORIDA, DEPT MAT SCI & ENGN, GAINESVILLE, FL 32611 USA. NR 9 TC 44 Z9 44 U1 0 U2 5 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 30 PY 1996 VL 69 IS 14 BP 2083 EP 2085 DI 10.1063/1.116887 PG 3 WC Physics, Applied SC Physics GA VJ783 UT WOS:A1996VJ78300032 ER PT J AU Porter, DW Nealley, EW Baskin, SI AF Porter, DW Nealley, EW Baskin, SI TI In vivo detoxification of cyanide by cystathionase gamma-lyase SO BIOCHEMICAL PHARMACOLOGY LA English DT Article DE cystathionase gamma-lyase; rhodanese; 3-mercaptopyruvate sulfurtransferase; cyanide detoxification; thiocyanate AB The results of several in vitro studies have suggested that the enzyme cystathionase gamma-lyase (EC 4.4.1.1) may function in the endogenous detoxification of cyanide; however, this possibility has not been investigated in vivo. If cystathionase gamma-lyase is involved in the endogenous detoxification of cyanide, it logically follows that inhibiting cystathionase gamma-lyase should increase the toxicity of cyanide. To test this hypothesis, the activity of cystathionase gamma-lyase was inhibited with a suicide inhibitor, 2-amino-4-pentynoic acid (propargylglycine). The activity of liver cystathionase gamma-lyase activity was decreased 96.8% by administration of propargylglycine, indicating that the propargylglycine treatment was effective. The propargylglycine treatment did not alter the activity of thiosulfate:cyanide sulfurtransferase (EC 2.8.1.1) or 3-mercaptopyruvate:cyanide sulfurtransferase (EC 2.8.1.2), two other enzymes that have been proposed to be involved in the detoxification of cyanide. The LD(50) of cyanide in rats treated with propargylglycine was 5.14 +/- 0.029 mg NaCN/kg, which was significantly (P < 0.05) lower than the 5.98 +/- 0.008 mg NaCN/kg LD(50) of cyanide determined in control rats. The results of these studies suggest that cystathionase gamma-lyase may participate in the detoxification of cyanide in vivo. C1 USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,DIV PHARMACOL,ABERDEEN PROVING GROUND,MD 21010. NR 25 TC 26 Z9 27 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0006-2952 J9 BIOCHEM PHARMACOL JI Biochem. Pharmacol. PD SEP 27 PY 1996 VL 52 IS 6 BP 941 EP 944 DI 10.1016/0006-2952(96)00466-2 PG 4 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA VD957 UT WOS:A1996VD95700017 PM 8781514 ER PT J AU Smack, DP Harrington, AC Dunn, C Howard, RS Szkutnik, AJ Krivda, SJ Caldwell, JB James, WD AF Smack, DP Harrington, AC Dunn, C Howard, RS Szkutnik, AJ Krivda, SJ Caldwell, JB James, WD TI Infection and allergy incidence in ambulatory surgery patients using white petrolatum vs bacitracin ointment - A randomized controlled trial SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID STAPHYLOCOCCUS-AUREUS; TOPICAL ANTIBIOTICS; AGENTS; ANAPHYLAXIS; DERMATITIS; WOUNDS AB Objective.-To assess the effect of white petrolatum vs bacitracin ointment on wound infection incidence, allergic contact dermatitis incidence, and healing characteristics. Design.-Randomized, double-blind, prospective trial comparing white petrolatum with bacitracin ointment in postprocedure wound care. Setting.-A general outpatient dermatology clinic and a tertiary referral advanced surgical procedure clinic at Waiter Reed Army Medical Center, Washington, DC. Patients.-A total of 922 patients who had dermatologic surgery with a total of 1249 wounds. Main Outcome Measures.-The incidence of infection and allergic contact dermatitis during a follow-up period of 4 weeks. Healing characteristics were secondary outcomes. Results.-Of the 922 patients enrolled, 440 in the white petrolatum group and 444 in the bacitracin group were evaluable for clinical response. The 2 treatment groups had comparable baseline characteristics. Thirteen patients developed postprocedure infection (1.5%), 9 (2.0%) in the white petrolatum group vs 4 (0.9%) in the bacitracin group (95% confidence interval for difference, -0.4% to 2.7%; P=.37). Eight infections (1.8%) in the white petrolatum group were due to Staphylococcus aureus vs none in the bacitracin group (P=.004). No patient in the group using white petrolatum developed allergic contact dermatitis vs 4 patients (0.9%) in the group using bacitracin (P=.12). Additionally, there were no clinically significant differences in healing between the treatment groups on day 1 (P=.98), day 7 (P=.85), or day 28 (P=.28) after the procedure. Conclusions.-White petrolatum is a safe, effective wound care ointment for ambulatory surgery, In comparison with bacitracin, white petrolatum possesses an equally low infection rate and minimal risk for induction of allergy. C1 WALTER REED ARMY MED CTR,DEPT DERMATOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT PHARM,WASHINGTON,DC 20307. NR 42 TC 131 Z9 131 U1 0 U2 3 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD SEP 25 PY 1996 VL 276 IS 12 BP 972 EP 977 DI 10.1001/jama.276.12.972 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA VH990 UT WOS:A1996VH99000038 PM 8805732 ER PT J AU Sciuto, AM Stotts, RR Chittenden, V Choung, E Heflin, MD AF Sciuto, AM Stotts, RR Chittenden, V Choung, E Heflin, MD TI Changes in absorbance at 413 nm in plasma from three rodent species exposed to phosgene SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article ID HEMOLYSIS; TOXICITY AB Mice, rats and guinea pigs were exposed to phosgene (COCl2), a highly irritating and oxidizing gas. Animals were exposed to 87 mg/m(3) phosgene for 20 min in a whole-body exposure chamber. Within 55-65 minutes after the start of exposure, plasma was scanned spectrophotometrically from 200-600 nm. A distinct and significant increase in area under the curve in the Soret band region at 413 nm was observed in plasma from phosgene-exposed animals when compared with air-exposed controls in all three species. These peaks were consistent with hemoglobin, an indication that the integrity of the erythrocyte membrane had been compromised by exposure. An erythrocyte osmotic fragility assay on blood from mice exposed to phosgene indicated that 30% less NaCl was needed to cause 50% hemolysis compared to air-exposed mice. These results suggest a new mechanism of phosgene-induced acute lung injury that may be linked, in part, to a direct attack on the erythrocyte membrane. (C) 1996 Academic Press, Inc. RP Sciuto, AM (reprint author), USA,MED RES INST CHEM DEF,PHYSIOL BRANCH,DIV PATHOPHYSIOL,ABERDEEN PROVING GROUND,MD 21010, USA. NR 23 TC 13 Z9 13 U1 0 U2 2 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0006-291X J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD SEP 24 PY 1996 VL 226 IS 3 BP 906 EP 911 DI 10.1006/bbrc.1996.1448 PG 6 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA VL164 UT WOS:A1996VL16400049 PM 8831709 ER PT J AU Premachandran, RS Banerjee, S Wu, XK John, VT McPherson, GL Akkara, J Ayyagari, M Kaplan, D AF Premachandran, RS Banerjee, S Wu, XK John, VT McPherson, GL Akkara, J Ayyagari, M Kaplan, D TI Enzymatic synthesis of fluorescent naphthol-based polymers SO MACROMOLECULES LA English DT Article ID PEROXIDASE; POLYMERIZATION; FILM AB A fluorescent polymer of 2-naphthol is prepared using the oxidative enzyme horseradish peroxidase encapsulated in the microstructured system of AOT/isooctane reversed micelles. The monomer, being amphiphilic, partitions to the oil-water interface with the hydroxyl moieties directed toward the microaqueous core. The enzyme is encapsulated in the water core. The precipitated polymer of naphthol has the morphology of single and interconnected microspheres and is soluble in a range of polar and nonpolar organic solvents. Poly(2-naphthol) shows a fluorescence characteristic of the naphthol chromophore and an additional well-resolved fluorescence attributed to an extended quinonoid structure attached to the polymer backbone. Further evidence of the quinonoid structure is obtained through UV, IR, and NMR spectroscopy. Characteristics of the synthesis and structure of poly(2-naphthol) are compared with those of a less fluorescent polymer, poly(4-ethylphenol). C1 TULANE UNIV,DEPT CHEM ENGN,NEW ORLEANS,LA 70118. TULANE UNIV,DEPT CHEM,NEW ORLEANS,LA 70118. USA,SOLDIER SYST COMMAND,NATICK,MA 01760. RI John, Vijay/G-3747-2010 NR 36 TC 95 Z9 100 U1 1 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD SEP 23 PY 1996 VL 29 IS 20 BP 6452 EP 6460 DI 10.1021/ma960468f PG 9 WC Polymer Science SC Polymer Science GA VJ531 UT WOS:A1996VJ53100014 ER PT J AU Mascola, JR Louder, MK Surman, SR Vancott, TC Yu, XF Bradac, J Porter, KR Nelson, KE Girard, M McNeil, JG McCutchan, FE Birx, DL Burke, DS AF Mascola, JR Louder, MK Surman, SR Vancott, TC Yu, XF Bradac, J Porter, KR Nelson, KE Girard, M McNeil, JG McCutchan, FE Birx, DL Burke, DS TI Human immunodeficiency virus type 1 neutralizing antibody serotyping using serum pools and an infectivity reduction assay SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID MONOCLONAL-ANTIBODIES; ENVELOPE GLYCOPROTEIN; PHYLOGENETIC ANALYSIS; NORTHERN THAILAND; HIV TYPE-1; DIVERSITY; SUBTYPES; GP120; AIDS; SENSITIVITY AB Classification of human immunodeficiency virus type 1 (HIV-1) by neutralization serotype may be important for the design of active and passive immunization strategies. Neutralizing antibody serotyping is hindered by the lack of standard reagents and assay format, and by the weak activity of many individual sera. To facilitate cross-clade neutralization analysis, we used an infectivity reduction assay (IRA) and selected clade-specific serum (or plasma) pools from subjects infected with clade B and E HIV-1, respectively, Several serum pools were utilized; some were selected for strong neutralizing activity against intraclade viruses and others were derived from conveniently available samples, Against a panel of 51 clade B and E viruses, serum pools displayed strong neutralization of most intraclade viruses and significantly diminished cross-clade neutralization, Results mere confirmed against a blinded panel of 20 viruses, The data indicate that the phylogenetic classification of virus subtypes B and E corresponds to two distinct neutralization serotypes, This approach to neutralizing antibody serotyping may be useful in defining the antigenic relationship among viruses from other clades. C1 USN,MED RES INST,DEPT INFECT DIS,BETHESDA,MD 20889. HENRY M JACKSON FDN,ROCKVILLE,MD 20850. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,BALTIMORE,MD 21205. NIAID,DIV AIDS,NIH,ROCKVILLE,MD 20892. INST PASTEUR,PARIS,FRANCE. RP Mascola, JR (reprint author), WALTER REED ARMY INST RES,DIV RETROVIROL,13 TAFT COURT,SUITE 200,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 FU NIDA NIH HHS [DA 09541] NR 43 TC 67 Z9 68 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD SEP 20 PY 1996 VL 12 IS 14 BP 1319 EP 1328 DI 10.1089/aid.1996.12.1319 PG 10 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA VJ248 UT WOS:A1996VJ24800004 PM 8891111 ER PT J AU Salminen, MO Johansson, B Sonnerborg, A Ayehunie, S Gotte, D Leinikki, P Burke, DS McCutchan, FE AF Salminen, MO Johansson, B Sonnerborg, A Ayehunie, S Gotte, D Leinikki, P Burke, DS McCutchan, FE TI Full-length sequence of an Ethiopian human immunodeficiency virus type 1 (HIV-1) isolate of genetic subtype C SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID POLYMERASE CHAIN-REACTION; NF-KAPPA-B; PHYLOGENETIC ANALYSIS; STRAINS; EPIDEMIOLOGY; AFRICAN; EXPRESSION; THAILAND; INDIA; AIDS AB Genetic subtype C of the human immunodeficiency virus type-1 (HIV-1) has established foci of infection in India and in at least eight African countries, and is expected to contribute significantly to the global pandemic, Here we report the first almost full-length sequence of a subtype C HIV-1 from Ethiopia, Clone C2220, 9031 nt in length, was derived by long PCR amplification of proviral DNA from virus cultured on primary peripheral blood mononuclear cells, and contains all but 74 nt of the unique sequence information of the HIV-1 genome, This clone resembles HIV-1 isolates of subtypes A, B, and D in its genome organization with one notable exception: the core promoter contains not two, but three potential binding sites for the transcription factor NF-kB. The extra NF-kB site was found in all other Ethiopian strains analyzed, as well as in subtype C viruses from Zambia, suggesting it is typical for the C-subtype of HIV-1, The phylogenetic relationship of C2220 to other HIV-1 isolates is also presented, Subtype C viruses circulating in Ethiopia exhibit the low interisolate diversity typical of other, newly established HIV-1 epidemics, and C2220 is both representative of Ethiopian subtype C viruses and a suitable prototype for the development of vaccines against HIV-1 subtype C. C1 WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD 20850. HUDDINGE UNIV HOSP,LAB CLIN VIROL,S-14186 HUDDINGE,SWEDEN. DANA FARBER CANC INST,LAB VIRAL PATHOGENESIS,BOSTON,MA 02115. NATL PUBL HLTH INST,HIV LAB,FIN-00300 HELSINKI,FINLAND. RP Salminen, MO (reprint author), HENRY M JACKSON FDN ADVANCEMENT MIL MED,1600 E GUDE DR,ROCKVILLE,MD 20850, USA. RI Salminen, Mika/D-8784-2013; OI Salminen, Mika/0000-0003-3020-0866; /0000-0002-5704-8094 NR 40 TC 67 Z9 77 U1 0 U2 2 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD SEP 20 PY 1996 VL 12 IS 14 BP 1329 EP 1339 DI 10.1089/aid.1996.12.1329 PG 11 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA VJ248 UT WOS:A1996VJ24800005 PM 8891112 ER PT J AU Barbiero, RP Speziale, BJ Ashby, SL AF Barbiero, RP Speziale, BJ Ashby, SL TI Phytoplankton community succession in a lake subjected to artificial circulation SO HYDROBIOLOGIA LA English DT Article DE phytoplankton succession; artificial circulation; intermediate disturbance ID BLUE-GREEN-ALGAE; DIVERSITY; RESERVOIR; DESTRATIFICATION; POPULATIONS; DOMINANCE; NITROGEN; BIOMASS; SHALLOW; GROWTH AB East Sidney Lake, a small, eutrophic bottom release impoundment in NY, has undergone artificial circulation for three seasons. The artificial circulation system resulted in an overall reduction in the physical stability of the water column, making the lake subject to alternating periods of weak chemical stratification and mixing. Phytoplankton community succession exhibited a high degree of regularity from year to year, culminating in mid summer dominance by heterocystous cyanophytes in all years. Changes in the physical structure of the water column, with attendant changes in Z(eu):Z(mix), were not important determinants of phytoplankton community makeup in East Sidney Lake. Seasonal patterns and community characteristics were not affected by artificially induced alterations in stability, but instead were most sensitive to surface temperatures, flushing rate and TN:TP. The timing of cyanophyte blooms was not affected by artificial circulation, nor was maximum seasonal phytoplankton biomass reduced. C1 ASCI CORP,VICKSBURG,MS 39180. CLEMSON UNIV,CLEMSON,SC 29634. USA,CORPS ENGINEERS,WATERWAYS EXPT STN,VICKSBURG,MS 39180. NR 43 TC 5 Z9 5 U1 0 U2 8 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0018-8158 J9 HYDROBIOLOGIA JI Hydrobiologia PD SEP 20 PY 1996 VL 331 IS 1-3 BP 109 EP 120 DI 10.1007/BF00025412 PG 12 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA VR839 UT WOS:A1996VR83900011 ER PT J AU Pai, SV Chabalowski, CF Rice, BM AF Pai, SV Chabalowski, CF Rice, BM TI Comparative study of nonlocal density functional theory and ab initio methods: The potential energy surface of sym-triazine reactions SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID GAUSSIAN-BASIS SETS; CORRELATED MOLECULAR CALCULATIONS; TRANSITION-STATES; ORBITAL METHODS; EXACT EXCHANGE; WAVE-FUNCTIONS; ELECTRON-GAS; HYDROGEN; ATOMS; APPROXIMATION AB Stable points and transition states on the potential energy surface (PES) for sym-triazine (C3N3H3) have been calculated by using nonlocal density functional (NDFT) methods. Two decomposition mechanisms for sym-triazine are investigated. The first is a concerted triple dissociation of the sym-triazine ring to form the HCN products. Three-fold symmetry is maintained along the reaction path for this mechanism. The second is a stepwise decomposition mechanism involving the formation of an intermediate dimer species. The NDFT results, including structures, relative energies, harmonic vibrational frequencies, and corresponding eigenvectors, are compared with previously reported nb initio calculations. These results include critical points located and characterized through normal mode analyses at the MP2 level. QCISD(T) energy refinements of the MP2 critical points are used for the comparison of DFT predictions. Basis set size dependence is also examined. The nonlocal density functionals used are the exchange functional of Becke and the correlation energy functional of Perdew (BP86), Becke's exchange and the correlation energy functional of Lee, Yang, and Parr (BLYP), Becke's three-parameter hybrid exchange functional with the LYP correltation energy functional (B3LYP), and the Becke exchange with Perdew and Wang's 1991 gradient-corrected correlation functional (BPW91). Basis sets used are 6-31G**, 6-311++G**, and cc-pVTZ. The reaction endothermicity predicted by B3LYP and BPW91 are in closer agreement with experiment than the QCISD(T) and MP2 predictions using the largest basis set. B3LYP predictions are within 1.1 kcal/mol of experiment. BPW91, BPSG, and BLYP frequencies agree most closely with experimental values for sym-triazine and HCN. DFT eigenvectors corresponding to vibrational modes for critical points on the PES compare well with MP2 predictions for most modes, indicating similarity in force fields and, therefore, atomic motion for the vibrations. Geometries predicted by all methods are in excellent agreement with experimental values for sym-triazine and HCN. All methods predict that the concerted triple-dissociation mechanism is the low-energy decomposition pathway for sym-triazine. DFT predictions of energies along the reaction path for the concerted triple-dissociation reaction are in qualitative agreement with MP2. All DFT methods predict structures of species along the reaction path that are in quantitative agreement with MP2 predictions. C1 USA, RES LAB, ABERDEEN PROVING GROUND, MD 21005 USA. NR 42 TC 21 Z9 21 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD SEP 19 PY 1996 VL 100 IS 38 BP 15368 EP 15382 DI 10.1021/jp960678u PG 15 WC Chemistry, Physical SC Chemistry GA VH463 UT WOS:A1996VH46300011 ER PT J AU Jatoi, I AF Jatoi, I TI Detection and treatment of ductal carcinoma in situ of the breast SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter ID CANCER; WOMEN RP Jatoi, I (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 4 TC 1 Z9 1 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD SEP 18 PY 1996 VL 276 IS 11 BP 870 EP 870 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA VF787 UT WOS:A1996VF78700018 PM 8782629 ER PT J AU Gurevich, VL Pevzner, VB Iafrate, G AF Gurevich, VL Pevzner, VB Iafrate, G TI Far-infrared radiation generated by current carrying nanowires SO PHYSICAL REVIEW LETTERS LA English DT Article ID LANDAUER RESISTANCE AB Resonant far-infrared photon generation in nanostructures is predicted whenever the energy separation between the subbands of a nanostructure is equal to the photon energy and the generation condition eV > (h) over bar omega is met. The far-infrared radiation with frequencies in the range of 10(12) to 3 x 10(13) s(-1) is expected. C1 N CAROLINA STATE UNIV,DEPT ELECT ENGN,RALEIGH,NC 27695. USA,RES OFF,RES TRIANGLE PK,NC 27709. AF IOFFE PHYS TECH INST,DIV SOLID STATE PHYS,ST PETERSBURG 194021,RUSSIA. RI V*L Gurevich, Vadim/E-9453-2014 NR 9 TC 1 Z9 1 U1 0 U2 0 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD SEP 16 PY 1996 VL 77 IS 12 BP 2534 EP 2537 DI 10.1103/PhysRevLett.77.2534 PG 4 WC Physics, Multidisciplinary SC Physics GA VG674 UT WOS:A1996VG67400048 ER PT J AU Krakauer, T AF Krakauer, T TI Evidence for protein kinase C pathway in the response of human peripheral blood mononuclear cells to cholera toxin SO CELLULAR IMMUNOLOGY LA English DT Article ID INTESTINAL EPITHELIAL-CELLS; IMMUNE-RESPONSES; B SUBUNIT; ADJUVANT; INTERLEUKIN-6; ACTIVATION; PROLIFERATION; IMMUNIZATION; CYTOKINES AB Cholera toxin (CT) is a potent mucosal adjuvant and is widely used for vaccine studies in animal models. However, there have been few studies that describe the immunomodulating effects of CT on cells of the human immune system. In this study, the immunomodulatory properties of CT on human peripheral blood mononuclear cells (PBMC) were examined to gain in sights to its effects on cells of the human immune system. CT induced production of immunostimulating (IL-1 beta and IL-6) and immunosuppressive (IL-10) cytokines by PBMC. However, the dose-response curve of its cytokine-inducing activity did not correlate well with the concentrations of intracellular cAMP generated by varying doses of CT. The CT mode of action on human PBMC, regarding induction of these cytokines, was clarified by the use of inhibitors of adenyl cyclase, protein kinase A (PKA), and protein kinase C (PKC). 2',3'-Dideoxyadenosine, which inhibits adenyl cyclase activity, reduced IL-1, IL-6, and IL-10 levels by 29, 15, and 28% respectively. HA1004, an inhibitor of PKA, reduced the IL-1 and IL-6 levels by 29 and 27%, respectively. The PKC inhibitor, H7, completely blocked the induction of all three cytokines by CT, suggesting a cAMP-independent mode of action for CT on human PBMC, These observations suggest that CT induces immunomodulating cytokines from human PBMC via the PKC pathway. (C) 1996 Academic Press, Inc. RP Krakauer, T (reprint author), USA,MED RES INST INFECT DIS,DEPT MOL BIOL & IMMUNOL,FT DETRICK,MD 21702, USA. NR 26 TC 15 Z9 15 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0008-8749 J9 CELL IMMUNOL JI Cell. Immunol. PD SEP 15 PY 1996 VL 172 IS 2 BP 224 EP 228 DI 10.1006/cimm.1996.0236 PG 5 WC Cell Biology; Immunology SC Cell Biology; Immunology GA VJ542 UT WOS:A1996VJ54200011 PM 8964084 ER PT J AU Kanan, AM LiKamWa, P MitraDutta Pamulapati, J AF Kanan, AM LiKamWa, P MitraDutta Pamulapati, J TI Area-selective disordering of multiple quantum well structures and its applications to all-optical devices SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID INTERDIFFUSION; DIFFUSION; IMPURITY; SUPERLATTICES; SHAPES; GA AB A technique of impurity-free vacancy-induced disordering of GaAs/AlGaAs multiquantum wells (MQW) that is area selective, very reliable, and highly reproducible, has been developed. The localized compositional disordering is induced by rapid thermal annealing of the sample after it has been coated with a thin film of ''spin-on'' glass and prebaked at 400 degrees C in a high purity nitrogen:oxygen (78:22) atmosphere. In order to self-consistently determine the diffusion coefficient of the Al and Ga atoms, the photoluminescence peak is fitted to the n=1 electron to heavy hole transition that corresponds to an error function potential profile caused by the diffusion. The process has been used to integrate two optical devices on a MQW structure. One is a nonlinear directional coupler all-optical switch, and the other is an integrated Mach-Zehnder all-optical modulator. The switching characteristics of the devices were measured using the conventional pump-probe measurement technique. (C) 1996 American Institute of Physics. C1 USA,RES LAB,ADELPHI,MD 20783. UNIV CENT FLORIDA,DEPT ELECT & COMP ENGN,ORLANDO,FL 32816. RP Kanan, AM (reprint author), UNIV CENT FLORIDA,CTR RES & EDUC OPT & LASERS,POB 162 700,4000 CENT FLORIDA BLVD,ORLANDO,FL 32816, USA. NR 16 TC 11 Z9 11 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 15 PY 1996 VL 80 IS 6 BP 3179 EP 3183 DI 10.1063/1.363257 PG 5 WC Physics, Applied SC Physics GA VG681 UT WOS:A1996VG68100007 ER PT J AU Joseph, J Aranda, FJ Rao, DVGLN Akkara, JA Nakashima, M AF Joseph, J Aranda, FJ Rao, DVGLN Akkara, JA Nakashima, M TI Optical Fourier processing using photoinduced dichroism in a bacteriorhodopsin film SO OPTICS LETTERS LA English DT Article ID COHERENT AB The photoinduced dichroism in bacteriorhodopsin films has been investigated in view of its application for optical Fourier processing. A simple optical system for Fourier processing is demonstrated that does not require precise alignment and vibration isolation. The basic principle of operation relies on the intensity dependence of photoinduced dichroism in a bacteriorhodopsin film. Experimental results with Fourier processing are shown for edge enhancement. (C) 1996 Optical Society of America C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. RP Joseph, J (reprint author), UNIV MASSACHUSETTS,DEPT PHYS,BOSTON,MA 02125, USA. RI Rao, Devulapalli/L-8863-2015 NR 17 TC 43 Z9 44 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD SEP 15 PY 1996 VL 21 IS 18 BP 1499 EP 1501 DI 10.1364/OL.21.001499 PG 3 WC Optics SC Optics GA VG594 UT WOS:A1996VG59400029 PM 19881704 ER PT J AU Sharma, PL Chatis, PA Dogon, AL Mayers, DL McCutchan, FE Page, C Crumpacker, CS AF Sharma, PL Chatis, PA Dogon, AL Mayers, DL McCutchan, FE Page, C Crumpacker, CS TI AZT-related mutation Lys70Arg in reverse transcriptase of human immunodeficiency virus type 1 confers decrease in susceptibility to ddATP in in vitro RT inhibition assay SO VIROLOGY LA English DT Article ID ZIDOVUDINE RESISTANCE MUTATIONS; POL GENE-MUTATIONS; REDUCED SENSITIVITY; CELL-CULTURE; IN-VIVO; THERAPY; HIV-1; DIDANOSINE; DIDEOXYINOSINE; VARIANTS AB The genetic basis for didanosine (ddl) resistance in human immunodefeciency virus (HIV-1) has previously been shown to be commonly associated with a Leu to Val change at codon 74 in the HIV-1 RT gene. In this study sequential viral isolates were analyzed from five patients with prior zidovudine (ATT) use who received 6 to 16 months of ddl therapy. Following ddl therapy, viral isolates exhibited an increased ATT susceptibility and decreased ddl susceptibility. Sequence and nested PCR analysis of the HIV-1 RT gene revealed that two viral isolates contained the Leu to Val change at codon 74, and three other isolates with reduced susceptibility to ddl each contained changes at codons 65, 70, and 72. Site-directed mutagenesis was employed to insert specific mutations in RT gene of proviral clone pNL4-3. Analysis of virion-associated reverse transcriptase activity indicated that the Lys70Arg mutation resulted in an enzyme with 2- to 4-fold decreased susceptibility to ddATP. Statistical analysis of the inhibitory concentration for RT activity between pNF4-3 and mutant Lys70Arg viruses obtained in three independent RT inhibition assays was significant (P = 0.05) by student t test paired analysis. Drug susceptibility assays on the virus with Lys70Arg mutation showed a marginal decrease in susceptibility to ddl (1.5- to 2-fold) and about 4- to 6-fold decrease in susceptibilty to AZT. Mutations Lys65Glu and Arg72Ser resulted in an impaired RT with greatly diminished functional RT activity. The AZT-associated Lys70Arg mutation results in an RT enzyme with decreased susceptibility to ddATP, (C) 1996 Academic Press, Inc. C1 BETH ISRAEL HOSP,DEPT MED,BOSTON,MA 02215. HARVARD UNIV,SCH MED,BOSTON,MA 02215. DU PONT,BOSTON,MA. WALTER REED ARMY INST RES,ROCKVILLE,MD 20850. USN,MED RES INST,ROCKVILLE,MD 20850. HENRY M JACKSON FDN RES LABS,ROCKVILLE,MD 20850. RP Sharma, PL (reprint author), BETH ISRAEL HOSP,DIV INFECT DIS,BOSTON,MA 02215, USA. FU NIAID NIH HHS [AI-29173, AI-01101, AI-62354] NR 42 TC 9 Z9 9 U1 1 U2 2 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD SEP 15 PY 1996 VL 223 IS 2 BP 365 EP 369 DI 10.1006/viro.1996.0488 PG 5 WC Virology SC Virology GA VJ810 UT WOS:A1996VJ81000011 PM 8806572 ER PT J AU Nosten, F Luxemburger, C Kyle, DE Ballou, WR Wittes, J Wah, E Chongsuphajaisiddhi, T Gordon, DM White, NJ Sadoff, JC Heppner, DG Bathe, K Blood, J Brockman, A Cobley, UT Hacking, D Hogg, D U, KH Maelankiri, L Chuanak, N Permpanich, B Price, R Raimond, D Schabenberger, O Singharaj, P Singhasivanon, P Slight, T Tulayon, S Tway, KL Ynint, T VincentiDelmas, M deVries, A Webster, HK AF Nosten, F Luxemburger, C Kyle, DE Ballou, WR Wittes, J Wah, E Chongsuphajaisiddhi, T Gordon, DM White, NJ Sadoff, JC Heppner, DG Bathe, K Blood, J Brockman, A Cobley, UT Hacking, D Hogg, D U, KH Maelankiri, L Chuanak, N Permpanich, B Price, R Raimond, D Schabenberger, O Singharaj, P Singhasivanon, P Slight, T Tulayon, S Tway, KL Ynint, T VincentiDelmas, M deVries, A Webster, HK TI Randomised double-blind placebo-controlled trial of SPf66 malaria vaccine in children in northwestern Thailand SO LANCET LA English DT Article ID PLASMODIUM-FALCIPARUM MALARIA; SYNTHETIC VACCINE; FIELD TRIALS; EFFICACY; IMMUNOGENICITY; ARTESUNATE; SAFETY AB Background Previous efficacy trials of SPf66 malaria vaccine have produced conflicting results in different populations. We report a randomised double-blind trial of the SPf66 vaccine conducted in Karen children aged 2-15 living in a malarious region of northwestern Thailand. Recombinant hepatitis B vaccine was used as a comparator. Methods The study had a power of 90% to detect an efficacy of 30%, defined as a reduction in the incidence of first cases of symptomatic falciparum malaria after three doses of vaccine. 1221 children received three immunisations acid were eligible for the primary efficacy analysis. Intense active and passive case detection continued over 15 months of follow-up. Findings The SPf66 vaccine was well tolerated, although 26 children had mild or moderately severe local or systemic allergic reactions, compared with none in the comparator group. The vaccine was immunogenic; after three doses, 73% of recipients had seroconverted. There were no deaths due to malaria during the study. During the 15-month period of evaluation there were 379 first cases of symptomatic falciparum malaria (195 in the SPf66 recipients, 184 in the comparator group); an SPf66 efficacy of -9% (95% CI -33 to 14, p=0.41). No significant differences between the two study groups in parasite density or any other measure of malaria-related morbidity were detected. Interpretation These findings are consistent with a recent study showing lack of efficacy of SPf66 among Gambian infants and differ from earlier positive reports from South America and evidence of borderline efficacy from Tanzania. We conclude that SPf66 does not protect against clinical falciparum malaria and that further efficacy trials are not warranted. C1 SHOKLO MALARIA RES UNIT,MAE SOT,THAILAND. MAHIDOL UNIV,FAC TROP MED,BANGKOK,THAILAND. AFRIMS,DEPT IMMUNOL & MED,BANGKOK,THAILAND. WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,DEPT IMMUNOL,WASHINGTON,DC. STAT COLLABORAT,WASHINGTON,DC. JOHN RADCLIFFE HOSP,NUFFIELD DEPT CLIN MED,OXFORD OX3 9DU,ENGLAND. RI White, Nicholas/I-4629-2012; OI Price, Richard/0000-0003-2000-2874; Nosten, Francois/0000-0002-7951-0745 FU Wellcome Trust NR 21 TC 136 Z9 139 U1 0 U2 4 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD SEP 14 PY 1996 VL 348 IS 9029 BP 701 EP 707 DI 10.1016/S0140-6736(96)04465-0 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA VG374 UT WOS:A1996VG37400008 PM 8806288 ER PT J AU Stanley, AE AF Stanley, AE TI Laser sensitized dissociation of tetramethyl germane SO JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY LA English DT Article DE tetramethyl germane; laser; sensitizer; simulation ID GAS-PHASE; PYROLYSIS; FILMS AB Tetramethyl germane was decomposed using laser sensitized photochemistry. Sulfur hexafluoride, a sensitizer, was added to gas phase tetramethyl germane and irradiated using a carbon dioxide, infrared, continuous wave laser under variable experimental conditions. The gas phase reactions were monitored before and after reaction using both Fourier transform infrared spectroscopy and gas chromatographic/mass spectral techniques. End product analysis showed that methane, ethene, and ethyne were the primary gaseous products. Germanium was identified visually as a gray solid. This laser sensitized dissociation of tetramethyl germane was optimized by a variation in irradiations and conditions such as sample pressure including sensitizer to reactant pressure ratio, laser power, and time. The yield of germane at the 1 s irradiation was 33% while at the 5 s irradiation, at 57% was observed. Both the rate of depletion of tetramethyl germane and the rate of formation of methane, ethene, and ethyne were determined at numerous irradiation times. Longer irradiation times and higher sulfur hexafluoride pressures produced higher yields. Experimental data from the time studies were used to generate simulated concentrations of reactants, reactive intermediates, and products as a function of time to a high degree of accuracy. The rate constants for the laser sensitized dissociation of tetramethyl germane using sulfur hexafluoride as a sensitizer were determined. Simulation analysis suggests that this reaction can be fit statistically to an eight-step reaction mechanism. These results are discussed and compared to similar literature studies of tetramethyl germane dissociations RP Stanley, AE (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,WEAPONS SCI DIRECTORATE,AMSMI,RD,WS,CM,REDSTONE ARSENAL,AL 35898, USA. NR 33 TC 4 Z9 4 U1 0 U2 2 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 1010-6030 J9 J PHOTOCH PHOTOBIO A JI J. Photochem. Photobiol. A-Chem. PD SEP 13 PY 1996 VL 99 IS 1 BP 1 EP 7 DI 10.1016/1010-6030(96)04352-3 PG 7 WC Chemistry, Physical SC Chemistry GA VH902 UT WOS:A1996VH90200001 ER PT J AU Wagner, GW Bartram, PW AF Wagner, GW Bartram, PW TI Reactions of the mustard simulant 2-chloroethyl phenyl sulfide with self-decontaminating sorbents. A C-13 MAS NMR study SO JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL LA English DT Article ID HYDROLYSIS AB Decomposition reactions for the mustard simulant 2-chloroethyl phenyl sulfide (C-13-labelled, CEPS*) sorbed on gamma-alumina, polydivinylbenzene (impregnated with NaOH, polyethylene glycol and polyethylenimine) (DVB/NaOH), and Ambergard(R) XE-555, were characterized in situ using C-13 MAS NMR. CEPS* hydrolyzes on gamma-alumina to form 2-hydroxyethyl phenyl sulfide. On DVB/NaOH, CEPS* eliminates HCl to yield vinyl phenyl sulfide, No products were observed on XE-555, where the applied CEPS* was spectroscopically observed to adsorb entirely within the micropores of the carbonaceous resin component of this material. Toxicities of the mustard products analogous to the degradation products observed for CEPS* are discussed. C1 USA,EDGEWOOD RDEC,RES & TECHNOL DIRECTORATE,ABERDEEN PROVING GROUND,MD 21010. RP Wagner, GW (reprint author), GEOCENTERS INC,GUNPOWDER BRANCH,BOX 68,ABERDEEN PROVING GROUND,MD 21010, USA. NR 12 TC 18 Z9 18 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1381-1169 J9 J MOL CATAL A-CHEM JI J. Mol. Catal. A-Chem. PD SEP 10 PY 1996 VL 111 IS 1-2 BP 175 EP 180 DI 10.1016/1381-1169(96)00226-9 PG 6 WC Chemistry, Physical SC Chemistry GA VH427 UT WOS:A1996VH42700021 ER PT J AU Vlahacos, CP Hameka, HF Jensen, JO AF Vlahacos, CP Hameka, HF Jensen, JO TI Theoretical studies of the infrared and Raman spectra of cubane SO CHEMICAL PHYSICS LETTERS LA English DT Article ID MOLECULAR-STRUCTURE AB We present computations of the structure and of the vibrational frequencies of the cubane molecule at the Hartree-Fock and the MP2 levels of theory with the 6-311G* basis set. We also present empirical correction factors for all computational data. The agreement between the corrected theoretical and the experimental data is satisfactory. C1 UNIV PENN,DEPT CHEM,PHILADELPHIA,PA 19104. USA,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP Vlahacos, CP (reprint author), SCI & TECHNOL CORP,HAMPTON,VA 23666, USA. NR 14 TC 40 Z9 41 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD SEP 6 PY 1996 VL 259 IS 3-4 BP 283 EP 286 DI 10.1016/0009-2614(96)00764-6 PG 4 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA VF841 UT WOS:A1996VF84100008 ER PT J AU Kagan, VE Day, BW Elsayed, NM Gorbunov, NV AF Kagan, VE Day, BW Elsayed, NM Gorbunov, NV TI Dynamics of haemoglobin SO NATURE LA English DT Letter ID HEMOGLOBIN; BLOOD; NO C1 UNIV PITTSBURGH,DEPT PHARMACEUT SCI,PITTSBURGH,PA 15238. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT RESP RES,WASHINGTON,DC 20307. RP Kagan, VE (reprint author), UNIV PITTSBURGH,DEPT ENVIRONM & OCCUPAT HLTH,PITTSBURGH,PA 15238, USA. NR 8 TC 9 Z9 9 U1 0 U2 1 PU MACMILLAN MAGAZINES LTD PI LONDON PA 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF SN 0028-0836 J9 NATURE JI Nature PD SEP 5 PY 1996 VL 383 IS 6595 BP 30 EP 31 DI 10.1038/383030b0 PG 2 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA VF295 UT WOS:A1996VF29500038 PM 8779713 ER PT J AU Hodgdon, JA Friedl, KE Beckett, MB Westphal, KA Shippee, RL AF Hodgdon, JA Friedl, KE Beckett, MB Westphal, KA Shippee, RL TI Use of bioelectrical impedance analysis measurements as predictors of physical performance SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article; Proceedings Paper CT National-Institutes-of-Health-Technology-Assessment Conference on Bioelectrical Impedance Analysis in Body Composition Measurement CY DEC 12-14, 1994 CL BETHESDA, MD SP NIDDKD, NIH, Off Med Applicat Res, NICHHD, NIA, NHLBI, USDA DE strength testing; bioelectrical impedance analysis; body composition; skinfold thickness; fat-free mass; military personnel; physical classification and selection tests ID FAT-FREE MASS; BODY-FAT; SKINFOLD THICKNESS; YOUNG MEN; DENSITY AB Through its association with fat-free mass (FFM), bioelectrical impedance analysis (BIA) offers an alternative to physical performance testing. We examined the relations between stature(2)/resistance (S-2/R), FFM, and muscular strength in data from three studies of young military men and women. Resistance was measured at 50 kHz by using the conventional tetrapolar electrode method. FFM was based on skinfold thicknesses, and estimated with the regression equations of Durnin and Womersley. Strength was measured as a one-repetition maximum on an incremental lift test (IL1RM), which is widely used by the military services to predict overall body strength. Although there was an association between IL1RM and S-2/R in each of these studies (correlations ranged from 0.35 to 0.53), correlations were strongest between FFM and S-2/R (R = 0.53 to 0.85), indicating that BIA and FFM derived from skinfold thicknesses are better correlated with each other than are the relations of either of these with physical performance. Modest increases in FFM and strength in one 8-wk training study correlated with S-2/R; however, large decreases in FFM and strength in another study (with weight losses of 10 kg in 8 wk) were not reflected by changes in S-2/R. Thus, BIA is not particularly useful for performance prediction despite its moderate relation to FFM. BIA is especially problematic with large changes in body composition, for which there are apparent deviations in hydration status; expedient methods such as skinfold predictions will be more resistant to such effects. C1 USA, ENVIRONM MED RES INST, OCCUPAT HLTH & PERFORMANCE DIRECTORATE, NATICK, MA 01760 USA. RP USN, HLTH RES CTR, DEPT HUMAN PERFORMANCE, POB 85122, SAN DIEGO, CA 92186 USA. NR 19 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0002-9165 EI 1938-3207 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD SEP PY 1996 VL 64 IS 3 SU S BP 463 EP 468 PG 6 WC Nutrition & Dietetics SC Nutrition & Dietetics GA VE984 UT WOS:A1996VE98400012 ER PT J AU Avery, RA Duncan, WE Alving, BM AF Avery, RA Duncan, WE Alving, BM TI Severe vitamin K deficiency induced by occult celiac disease BR96-026 SO AMERICAN JOURNAL OF HEMATOLOGY LA English DT Letter C1 WALTER REED ARMY MED CTR,DEPT ENDOCRINOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIV MED,WASHINGTON,DC 20307. RP Avery, RA (reprint author), WALTER REED ARMY MED CTR,DEPT HEMATOL ONCOL,WASHINGTON,DC 20307, USA. NR 5 TC 6 Z9 6 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0361-8609 J9 AM J HEMATOL JI Am. J. Hematol. PD SEP PY 1996 VL 53 IS 1 BP 55 EP 55 DI 10.1002/(SICI)1096-8652(199609)53:1<55::AID-AJH18>3.0.CO;2-2 PG 1 WC Hematology SC Hematology GA VK241 UT WOS:A1996VK24100021 PM 8813108 ER PT J AU Yuan, CM Bohen, EM Musio, F Carome, MA AF Yuan, CM Bohen, EM Musio, F Carome, MA TI Sublethal heat shock and cyclosporine exposure produce tolerance against subsequent cyclosporine toxicity SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL FLUID AND ELECTROLYTE PHYSIOLOGY LA English DT Article DE heat shock protein-70; cytotoxicity; cyclophilin; kidney; tubule ID METABOLIC STRESS; TUBULAR INJURY; RAT-KIDNEY; CELLS; PROTEIN; INDUCTION; ISCHEMIA; RECOVERY; LOCALIZATION; EXPRESSION AB Sublethal heat shock has been shown to produce tolerance in cells and tissues subsequently exposed to heat or ischemia/ATP depletion. We tested whether heating LLC-PK1 cells for 2 h at 42 degrees C induced heat shock protein-70 (HSP-70) gene expression and conferred tolerance against subsequent cyclosporine A (CyA) toxicity. HSP-70 mRNA was increased immediately after heat shock, returning to baseline by 4 h. HSP-70 protein increased by 1 h after heat shock and declined thereafter, approaching baseline after 72 h. Cells heat shocked at 4 and 24 h prior to CYA exposure were significantly more viable than controls, at CyA concentrations near the median lethal dose (LD(50)). Cytoprotection declined with time after heat shock, concurrent with declining HSP-70 protein levels. Sublethal CyA exposure (50 mu g/ml) for 24 h produced upregulation of HSP-70 mRNA and protein. Pretreatment with 50 mu g/ml CyA for 24 h followed by exposure to a toxic concentration of CyA (200 mu g/ml) produced significant cytoprotection compared with untreated controls. In conclusion, HSP-70 protein induction by sublethal heat shock. or CyA exposure was associated with tolerance against subsequent lethal CyA exposure. RP Yuan, CM (reprint author), WALTER REED ARMY MED CTR, DEPT MED, SERV NEPHROL, WASHINGTON, DC 20307 USA. NR 33 TC 23 Z9 23 U1 0 U2 1 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0363-6127 J9 AM J PHYSIOL-RENAL JI Am. J. Physiol.-Renal Fluid Electrolyte Physiol. PD SEP PY 1996 VL 271 IS 3 BP F571 EP F578 PG 8 WC Physiology; Urology & Nephrology SC Physiology; Urology & Nephrology GA VH215 UT WOS:A1996VH21500010 PM 8853418 ER PT J AU Williams, SC May, CC Contreras, M AF Williams, SC May, CC Contreras, M TI A nuclear medicine review manual on the Internet SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article ID IMAGING TEACHING FILE; WORLDWIDE WEB C1 UNIV TEXAS,HLTH SCI CTR,DEPT RADIOL,SAN ANTONIO,TX 78284. BROOKE ARMY MED CTR,DEPT RADIOL,FT SAM HOUSTON,TX 78234. RP Williams, SC (reprint author), MADIGAN ARMY MED CTR,DEPT RADIOL,9040-A REID ST,TACOMA,WA 98431, USA. NR 11 TC 7 Z9 7 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD SEP PY 1996 VL 167 IS 3 BP 585 EP 586 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA VD396 UT WOS:A1996VD39600007 PM 8751656 ER PT J AU Seeger, LL Hewel, KC Yao, L Gold, RH Mirra, JM Chandnani, VP Eckardt, JJ AF Seeger, LL Hewel, KC Yao, L Gold, RH Mirra, JM Chandnani, VP Eckardt, JJ TI Ribbing disease (multiple diaphyseal sclerosis): Imaging and differential diagnosis SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article ID ENGELMANN DISEASE; CAMURATI-ENGELMANN; DYSPLASIA; MANIFESTATIONS; BONE AB OBJECTIVE. This study describes the clinical presentation and the course of Ribbing disease in six patients and illustrates imaging features on plain radiography, conventional and computed tomography, and Tc-99m-methylene diphosphonate bone scans. MATERIALS AND METHODS. Between 1982 and 1990, six female patients presented with painful bony lesions that were believed to be Ribbing disease. Ten bones were affected: both tibiae in three patients, a unilateral tibia in one, both femora in one, and a unilateral femur in one. Plain radiographs and either conventional or computed tomography were available for all patients and Tc-99m-methylene diphosphonate bone scans, for five patients. All patients underwent open biopsy and/or surgical decompression. RESULTS. The diagnosis was reached in all patients through a combination of clinical findings (lack of systemic signs of infection or laboratory values suggesting metabolic bone disease), imaging, histologic evaluation, and specimen cultures. Radiographs and tomographic studies showed benign-appearing endosteal and periosteal cortical thickening. Intense uptake of radionuclide tracer was confined to the shaft of all involved bones. All pathologic specimens revealed nonspecific changes that included a slow increase in the mass of cortical and endosteal bone. These specimens also assisted in excluding neoplastic or infectious causes for the new bone formation. CONCLUSION. Ribbing disease is a rare disorder that, on imaging studies, may simulate stress fracture, chronic infection, bone-forming neoplasia, or a systemic metabolic or endocrine disorder. Clinical and imaging features may suggest the correct diagnosis. C1 ORTHOPED HOSP,DEPT PATHOL,LOS ANGELES,CA 90007. BROOKE ARMY MED CTR,DEPT RADIOL,FT SAM HOUSTON,TX 78234. UNIV CALIF LOS ANGELES,SCH MED,DEPT ORTHOPAED SURG,LOS ANGELES,CA 90095. RP Seeger, LL (reprint author), UNIV CALIF LOS ANGELES,SCH MED,DEPT RADIOL SCI,200 UCLA MED PLAZA,STE 165-59,LOS ANGELES,CA 90095, USA. NR 24 TC 21 Z9 23 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD SEP PY 1996 VL 167 IS 3 BP 689 EP 694 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA VD396 UT WOS:A1996VD39600034 PM 8751682 ER PT J AU Chang, PS Harris, RM AF Chang, PS Harris, RM TI Intramedullary nailing for chronic tibial stress fractures - A review of five cases SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article AB Chronic tibial stress fracture is an unusual condition that is primarily seen in athletes and military personnel. Recurrent or recalcitrant stress fractures can be career-ending because they require lengthy nonoperative treatment. We performed a retrospective review of five patients who underwent intramedullary tibial nailing for recalcitrant stress fractures at Womack Army Medical Center, Ft. Bragg, North Carolina, from 1991 to 1994. Interviews were used to survey the patient's history and outcome. We reviewed each case regarding preoperative symptoms, preoperative treatment, surgery performed, radiographic findings, and functional outcome. In each case there were several similarities in symptoms and, most notably, radiographic findings and failure of nonoperative therapy for more than 1 year. Each patient had an unusually narrow medullary canal, a thickened anterior cortex, and a linear unicortical fracture line on the anterior or tension side. Although functional results varied, all patients reported improvement in their symptoms and could return to limited running. There were two excellent results (defined as unlimited pain-free running and resolved tibial pain) and three good results. We believe intramedullary tibial nailing should be considered for treating chronic stress fractures of the midanterior tibia that are recalcitrant to nonoperative therapy in a selected group of patients. C1 WOMACK ARMY MED CTR,DEPT MUSCULOSKELETAL MED & ORTHOPAED SURG,FT BRAGG,NC. NR 22 TC 42 Z9 44 U1 0 U2 2 PU AMER ORTHOPAEDIC SOC SPORT MED PI WALTHAM PA 230 CALVARY STREET, WALTHAM, MA 02154 SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD SEP-OCT PY 1996 VL 24 IS 5 BP 688 EP 692 DI 10.1177/036354659602400522 PG 5 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA VH797 UT WOS:A1996VH79700022 PM 8883694 ER PT J AU Waddell, BE Harkins, MB Lepage, PA Modesto, VL Villavicencio, JL AF Waddell, BE Harkins, MB Lepage, PA Modesto, VL Villavicencio, JL TI The crochet hook method of stab avulsion phlebectomy for varicose veins SO AMERICAN JOURNAL OF SURGERY LA English DT Article AB Excision of varicose veins through ministab incisions is currently the choice for the removal of varicose vein clusters. The crochet hook technique of stab avulsion phlebectomy is described in this paper. This surgical method for the treatment of varicose veins has been widely utilized in a residency training environment during the last twelve years and has been used by the senior author for more than 20 years. The technique is easily mastered, cost effective, and has excellent therapeutic and cosmetic results. C1 UNIFORMED SERV UNIV HLTH SCI,NATL NAVAL MED CTR,DEPT SURG,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP Waddell, BE (reprint author), EISENHOWER ARMY MED CTR,DEPT SURG,BOX 742,FT GORDON,GA 30905, USA. NR 12 TC 5 Z9 5 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0002-9610 J9 AM J SURG JI Am. J. Surg. PD SEP PY 1996 VL 172 IS 3 BP 278 EP 280 DI 10.1016/S0002-9610(96)00111-0 PG 3 WC Surgery SC Surgery GA VK095 UT WOS:A1996VK09500016 PM 8862084 ER PT J AU Jatoi, I AF Jatoi, I TI Mammographic screenings for women under 50 SO AMERICAN JOURNAL OF SURGERY LA English DT Letter RP Jatoi, I (reprint author), BROOKE ARMY MED CTR,DEPT SURG,FT SAM HOUSTON,TX 78234, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0002-9610 J9 AM J SURG JI Am. J. Surg. PD SEP PY 1996 VL 172 IS 3 BP 304 EP 304 PG 1 WC Surgery SC Surgery GA VK095 UT WOS:A1996VK09500024 PM 8862092 ER PT J AU Miller, SK Martindale, RG Gao, XX Gadacz, TR AF Miller, SK Martindale, RG Gao, XX Gadacz, TR TI The effects of octreotide on healing of small bowel anastomosis SO AMERICAN SURGEON LA English DT Article ID SOMATOSTATIN ANALOG SMS-201-995; EPIDERMAL GROWTH-FACTOR; RAT T-KININOGEN; CARCINOID-SYNDROME; SMS 201-995; DNA-SYNTHESIS; VIPOMA; SURGERY; INTERLEUKIN-6; REGENERATION AB Octreotide (OCT) is a somatostatin analog used for its inhibitory action on multiple GI functions. Although octreotide has numerous clinical benefits, it has also been shown to inhibit postresectional hyperplasia of small bowel and hepatic regeneration. Because octreotide inhibits both trophic and anabolic hormones, we hypothesize that the use of octreotide may be detrimental in patients with a recent bowel anastomosis. To test this hypothesis, 60 male rats were randomized to four equal groups following small bowel anastomosis. Group I = control; Group II = 10 mg/day of hydrocortisone succinate; Group III = 2.5 mu g/kg/day octreotide (equivalent of a clinical dose); Group IV = 25 mu g/kg/day octreotide. Hydrocortisone was used as a negative control because it is known to have inhibitory effects on small bowel anastomotic healing. On postoperative Day 7, bursting pressures were measured. Serum T-kininogen levels, as a marker for systemic inflammation, and hydroxyproline content from the anastomotic segments were obtained. These results indicate that in the rat small bowel model, octreotide did not have any deleterious effect on anastomotic strength, systemic inflammation, and collagen content, even at high doses. Hydrocortisone, as expected, showed significant detrimental effects on bursting strength, as well as decreasing systemic inflammation. These findings have significant clinical implications, as octreotide could be used without jeopardizing the intestinal anastomosis. C1 USA,EISENHOWER MED CTR,DEPT SURG,AUGUSTA,GA. MED COLL GEORGIA,DEPT SURG,AUGUSTA,GA. NR 50 TC 8 Z9 9 U1 0 U2 1 PU SOUTHEASTERN SURGICAL CONGRESS PI ATLANTA PA 1776 PEACHTREE RD, NW., SUITE 410N, ATLANTA, GA 30309-2352 SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD SEP PY 1996 VL 62 IS 9 BP 733 EP 737 PG 5 WC Surgery SC Surgery GA VD845 UT WOS:A1996VD84500009 PM 8751764 ER PT J AU McLoughlin, TM Fontana, JL Alving, B Mongan, PD Bunger, R AF McLoughlin, TM Fontana, JL Alving, B Mongan, PD Bunger, R TI Profound normovolemic hemodilution: Hemostatic effects in patients and in a porcine model SO ANESTHESIA AND ANALGESIA LA English DT Article ID BLOOD-LOSS; OXYGEN-CONSUMPTION; CRITICAL-LEVEL; COAGULATION; DELIVERY; CELLS AB Previous systematic investigations of the hemostatic effects of normovolemic hemodilution (NHD) have not explored the influence of hematocrits less than 20% in humans or animals. However, clinical interest in maximizing the perioperative conservation of erythrocytes may involve profound NHD beyond traditionally accepted empiric end points. We report here on coagulation data in eight healthy adolescent patients undergoing profound NHD in concert with surgical correction of idiopathic scoliosis, and in 29 swine undergoing experimental stepwise NHD until death. Blood was replaced with 5% albumin in 0.9% saline in our patients, and with 5% albumin in lactated Ringer's solution in our pigs. A 75% blood volume exchange in our patients yielded a platelet count (PLT) of 158 +/- 26 X 10(3)/mu L, fibrinogen concentration (FIB), 50 +/- 7 mg/dL, prothrombin time (PT), 25.4 +/- 2.6 s, activated partial thromboplastin time (aPTT), 87 +/- 15 s, and a nadir hemoglobin of 2.8 +/- 0.2 g/dL; however, global oxygen delivery as assessed by body oxygen consumption remained adequate. Coagulation during the experimental porcine hemodilution was assessed by measuring PLT, FIB, PT, and aPTT, as well as by measurement of coagulation factor activities. In neither species did clinically significant thrombocytopenia (PLT < 100 X 10(3)/mu L) become manifest prior to clinical or other laboratory evidence of coagulopathy. Rather, a combined deficiency of coagulation factors explains the coagulopathy developing during NHD in both patients and swine. Abnormal hemostasis develops prior to compromise of global tissue oxygenation, assessed by mixed venous oxygen saturation and total body oxygen consumption, during NHD in healthy patients anesthetized as described. Therefore, NHD may be more limited by preservation of normal coagulation than of global oxygen delivery and consumption. C1 WALTER REED ARMY MED CTR,DEPT ANESTHESIOL,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DEPT HEMATOL & VASC BIOL,WASHINGTON,DC. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT ANESTHESIOL,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT PHYSIOL,BETHESDA,MD 20814. NR 25 TC 70 Z9 73 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD SEP PY 1996 VL 83 IS 3 BP 459 EP 465 DI 10.1097/00000539-199609000-00003 PG 7 WC Anesthesiology SC Anesthesiology GA VE600 UT WOS:A1996VE60000003 PM 8780263 ER PT J AU ONeill, BL Foley, EP AF ONeill, BL Foley, EP TI The neuromuscular blocking effects of cis-atracurium in children during sevoflurane anesthesia SO ANESTHESIOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT ANESTHESIOL,WASHINGTON,DC 20307. NR 4 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD SEP PY 1996 VL 85 IS 3A SU S BP A1058 EP A1058 PG 1 WC Anesthesiology SC Anesthesiology GA VM466 UT WOS:A1996VM46601058 ER PT J AU Stevens, JB Hecker, RB Talbot, JC Walker, SC AF Stevens, JB Hecker, RB Talbot, JC Walker, SC TI Hemodynamic effects of rocuronium compared to vecuronium and pancuronium under balanced anesthesia SO ANESTHESIOLOGY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,SAN ANTONIO,TX 78234. NR 2 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD SEP PY 1996 VL 85 IS 3A SU S BP A822 EP A822 PG 1 WC Anesthesiology SC Anesthesiology GA VM466 UT WOS:A1996VM46600822 ER PT J AU Bruno, JG Yu, H AF Bruno, JG Yu, H TI Immunomagnetic-electrochemiluminescent detection of Bacillus anthracis spores in soil matrices SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article AB Rapid (less than or equal to 1.5-h) detection of anthrax spores in soil suspensions was accomplished by an immunomagnetic electrochemiluminescence method. Strain-dependent detection limits in the range of 10(2) to 10(5) spores were achieved in buffer. The rank order of sensitivity for the assay in buffer was Sterne > Ames > Vollum 1B. Detection was up to 3 orders of magnitude less sensitive in soil suspensions, and the rank order of sensitivity was altered. C1 USA,EDGEWOOD RES DEV & ENGN CTR,SYST RES LABS,ABERDEEN PROVING GROUND,MD 21010. RP Bruno, JG (reprint author), USAF,ARMSTRONG LAB,ENVIRON DIRECTORATE,139 BARNES DR,STE 2,TYNDALL AFB,FL 32403, USA. NR 10 TC 39 Z9 44 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD SEP PY 1996 VL 62 IS 9 BP 3474 EP 3476 PG 3 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA VF616 UT WOS:A1996VF61600064 PM 16535408 ER PT J AU Farmer, KR Debauche, CP Giordano, AR Lundgren, P Andersson, MO Buchanan, DA AF Farmer, KR Debauche, CP Giordano, AR Lundgren, P Andersson, MO Buchanan, DA TI Weak fluence dependence of charge generation in ultra-thin oxides on silicon SO APPLIED SURFACE SCIENCE LA English DT Article; Proceedings Paper CT 5th International Conference on Formation of Semiconductor Interfaces (ICFSI-5) CY JUN 26-30, 1995 CL PRINCETON, NJ SP Princeton Univ, Adv Technol Ctr Photon & Optoelectr Mat, David Sarnoff Res Ctr, Epitaxx, Evans East, IBM, Int Rectifier Corp, US, Off Naval Res, Oxford Instruments Inc, Princeton Univ, Princeton Mat Inst, Princeton Univ, Sch Engn & Appl Sci, Sensors Unlimited, W Windsor Plainsboro H S German Club ID CREATION; DIOXIDE AB We examined charge generation in metal/tunnel-oxide/n-silicon diodes fabricated with polycrystalline silicon (poly-Si) gates. In these devices, electron injection from the substrate in the direct tunnel regime leads to charge generation which evolves with time rather than electron fluence, as has been previously reported for injection in the Fowler-Nordheim tunnel regime. Our findings complete the picture proving the existence of a distinct degradation mode in the direct tunnel regime for devices fabricated at different facilities, using both aluminum and polycrystalline silicon gates, and stressed via either gate or substrate injection. This work directly impacts the prediction of the lifetimes of devices in which direct tunneling is measurable. C1 USA,ELECT TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. CHALMERS UNIV TECHNOL,DEPT SOLID STATE ELECT,S-41296 GOTHENBURG,SWEDEN. IBM CORP,DIV RES,TJ WATSON RES CTR,YORKTOWN HTS,NY 10598. RP Farmer, KR (reprint author), NEW JERSEY INST TECHNOL,DEPT PHYS,UNIV HTS,NEWARK,NJ 07102, USA. RI Lundgren, Per/B-3115-2011 OI Lundgren, Per/0000-0003-3234-1670 NR 8 TC 4 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-4332 J9 APPL SURF SCI JI Appl. Surf. Sci. PD SEP PY 1996 VL 104 BP 369 EP 372 DI 10.1016/S0169-4332(96)00173-0 PG 4 WC Chemistry, Physical; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Chemistry; Materials Science; Physics GA VR573 UT WOS:A1996VR57300060 ER PT J AU Klatka, LA AF Klatka, LA TI Clinicopathological studies of Alzheimer disease - Reply SO ARCHIVES OF NEUROLOGY LA English DT Letter RP Klatka, LA (reprint author), WALTER REED ARMY MED CTR,DEPT ARMY,WASHINGTON,DC 20307, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-9942 J9 ARCH NEUROL-CHICAGO JI Arch. Neurol. PD SEP PY 1996 VL 53 IS 9 BP 837 EP 837 PG 1 WC Clinical Neurology SC Neurosciences & Neurology GA VG391 UT WOS:A1996VG39100004 ER PT J AU Ramirez, SG Loube, DI AF Ramirez, SG Loube, DI TI Inferior sagittal osteotomy with hyoid bone suspension for obese patients with sleep apnea SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Article ID UVULOPALATOPHARYNGOPLASTY; ADVANCEMENT; ABNORMALITIES; THERAPY; SURGERY AB Background: An inferior sagittal osteotomy with a sliding mandibular osteotomy and hyoid bone suspension, combined with a uvulopalatopharyngoplasty, is advocated in patients with obstructive sleep apnea who fail to tolerate nasal continuous positive airway pressure. Some investigators have suggested that this surgical procedure may be less effective in obese patients. Methods: Preoperative and postoperative nocturnal polysomnograms and lateral cephalometric radiographs were obtained on 12 obese patients with obstructive sleep apnea who underwent these procedures. Results: The mean +/- SD respiratory disturbance index during sleep decreased 53% +/- 11% after surgical procedures were performed (49 +/- 17 vs 23 +/- 11 events per hour, P < .001). Surgical outcome did not correlate with the body mass index, and 5 (71%) of 7 of the morbidly obese patients (body mass index, greater than or equal to 33) had greater than a 50% reduction in the respiratory disturbance index after the surgical procedures were done. Conclusion: An inferior sagittal osteotomy with a sliding mandibular osteotomy and hyoid bone suspension, combined with a uvulopalatopharyngoplasty, tends to improve obstructive sleep apnea in obese patients. C1 WALTER REED ARMY MED CTR,PULM & CRIT CARE MED SERV,WASHINGTON,DC 20307. BROOKE ARMY MED CTR,OTOLARYNGOL SERV,FT SAM HOUSTON,TX 78234. NR 20 TC 50 Z9 54 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD SEP PY 1996 VL 122 IS 9 BP 953 EP 957 PG 5 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA VG386 UT WOS:A1996VG38600008 PM 8797559 ER PT J AU Halverson, RR Bliese, PD AF Halverson, RR Bliese, PD TI Determinants of soldier support for operation uphold democracy SO ARMED FORCES & SOCIETY LA English DT Article ID ORGANIZATIONAL COMMITMENT AB A substantial number of U.S. Army soldiers deployed to Haiti for Operation Uphold Democracy did not believe it was important that the U.S. military be involved in the operation (49%); did not believe that what the U.S. military was doing was important (38%); and did not believe in the overall value of the operation (43%). At the same time, a substantial number of soldiers had positive feelings about what they were doing in Haiti and the mission they were accomplishing. The primary focus of this investigation was to examine factors that were related to the wide variation in soldier reports of support for Operation Uphold Democracy. The results indicated that a combination of soldier characteristics (e.g., race, gender), unit characteristics (e.g., unit type), task characteristics (e.g., task significance), and operational characteristics (e.g., perceptions of public support) accounted for nearly 50% of the variance in soldier reports of support for the overall operation. RP Halverson, RR (reprint author), WALTER REED ARMY INST RES,DIV NEUROPSYCHIAT,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307, USA. NR 8 TC 5 Z9 5 U1 0 U2 2 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD FAL PY 1996 VL 23 IS 1 BP 81 EP & DI 10.1177/0095327X9602300104 PG 17 WC Political Science; Sociology SC Government & Law; Sociology GA VV346 UT WOS:A1996VV34600004 ER PT J AU Murphy, FT Pugh, AM Larsen, SA George, RA Dennis, GJ AF Murphy, FT Pugh, AM Larsen, SA George, RA Dennis, GJ TI Confirmation of false positive syphilis serologies in patients with autoimmune disease. SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT RHEUMATOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN IMMUNOL,WASHINGTON,DC 20307. CTR DIS CONTROL,DIV SEXUALLY TRANSMITTED DIS LAB RES,DEPT TREPONEMAL PATHOGENESIS & IMMUNOBIOL,ATLANTA,GA 30333. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 1996 VL 39 IS 9 SU S BP 410 EP 410 PG 1 WC Rheumatology SC Rheumatology GA VH883 UT WOS:A1996VH88300410 ER PT J AU Kovacs, B Vassilopoulos, D Vogelgesang, SA Tsokos, GC AF Kovacs, B Vassilopoulos, D Vogelgesang, SA Tsokos, GC TI Defective CD3-mediated cell death in activated T cells from patients with systemic lupus erythematosus despite normal Fas and Fas ligand expression and function. Role of decreased intracellular TNF-alpha. SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract C1 WRAIR,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 1996 VL 39 IS 9 SU S BP 703 EP 703 PG 1 WC Rheumatology SC Rheumatology GA VH883 UT WOS:A1996VH88300705 ER PT J AU Liossis, SN Kovacs, B Dennis, G Kammer, G Tsokos, GC AF Liossis, SN Kovacs, B Dennis, G Kammer, G Tsokos, GC TI Cell signalling in human lupus lymphocytes: Lupus B cells display increased surface IgM and IgD-mediated free intracytoplasmic calcium responses. SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307. WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT MED,WINSTON SALEM,NC 27157. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 1996 VL 39 IS 9 SU S BP 1334 EP 1334 PG 1 WC Rheumatology SC Rheumatology GA VH883 UT WOS:A1996VH88301335 ER PT J AU Sutherland, RA Yee, YP Fernandez, GL Millard, JB AF Sutherland, RA Yee, YP Fernandez, GL Millard, JB TI Droplet size and transmittance spectra of mechanically generated water fogs SO ATMOSPHERIC RESEARCH LA English DT Article; Proceedings Paper CT 4th International Aerosol Conference CY AUG 28-SEP 02, 1994 CL UCLA, LOS ANGELES, CA HO UCLA ID RESPONSE CHARACTERISTICS; EXTINCTION AB The concept of using commercially available water fog generators to simulate natural fogs and military obscurants is investigated. Results obtained with a high-pressure direct impaction system developed for agricultural and environmental control applications are reported. Experiments verify that such systems can produce optically dense ''artificial fogs'' similar in appearance to natural fogs under favorable meteorological conditions. Measurements of the droplet mass distribution function indicate a broad spectrum in the lower size region (0.3-1.5 mu m) and a marked peak in the upper region at a diameter of about 17 mu m. Experiments show that droplet size can be partially controlled with common surfactants and inhibitors. The artificially generated fogs are good broadband obscurants, exhibiting a nearly flat transmittance spectrum in the visible through mid-infrared regions with a broad peak in the far infrared region. The measured extinction spectrum is similar to natural fogs, being in between the advective and radiative cases. C1 NEW MEXICO STATE UNIV,DEPT PHYS,LAS CRUCES,NM 88005. RP Sutherland, RA (reprint author), USA,RES LAB,ATMOSPHER EFFECTS BRANCH,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 39 TC 1 Z9 1 U1 1 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0169-8095 J9 ATMOS RES JI Atmos. Res. PD SEP PY 1996 VL 41 IS 3-4 BP 299 EP 319 DI 10.1016/0169-8095(96)00016-6 PG 21 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA VQ092 UT WOS:A1996VQ09200009 ER PT J AU Chang, SKW Santee, WR AF Chang, SKW Santee, WR TI Clothing insulation in a hypobaric environment SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID VAPOR; HEAT AB Hypothesis: Clothing insulation is the result of complex interactions between heat transfer mechanisms and clothing material thermal resistances. Hypobaria changes the heat transfer processes therefore should have observable effects on the clothing insulation. Methods: The effect of hypobaria on the thermal insulative properties of U.S. Army fatigue uniform (BDU) and U.S. Army chemical protective overgarment (BDO) were examined. Barometric pressure of 429 mmHg, comparable to the condition at terrestrial elevation of 4570 m (15,000 ft) above sea level was created in a hypobaric chamber. The sea level environment was used as a baseline condition. Results: Our data support a diminished convective heat transfer and an enhanced evaporative heat transfer at higher altitude. We also found that hypobaria had only a small effect on the intrinsic clothing insulation values. For the less insulative BDU, hypobaria did not appreciably affect clothing insulation values. For the more insulative BDO, a maximum difference of 0.2 clo (clo = 0.155 m(2) . K . W-1) was found between hypobaric and normobaric environments. Conclusion: Heavy clothing insulation forced the heat transfer processes at the skin surface to operate almost independently from those at the clothing surface. At the skin surface, evaporation was the dominant process, while at the outer clothing surface, convection dominated. At higher altitude, enhanced evaporative heat transfer resulted in a lower skin temperature, while reduced convective heat transfer hampered heat dissipation from clothing surface to the ambient environment, hence elevating the clothing temperature. Therefore, in hypobaric environment, the skin temperature was found to be lower, but the clothing temperature higher than at sea level. RP Chang, SKW (reprint author), USA,ENVIRONM MED RES INST,BIOPHYS & BIOMED MODELING DIV,MCMR UE EMB,KANSAS ST,NATICK,MA 01760, USA. NR 18 TC 6 Z9 6 U1 0 U2 2 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD SEP PY 1996 VL 67 IS 9 BP 827 EP 834 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA VF795 UT WOS:A1996VF79500002 PM 9025797 ER PT J AU Lieberman, HR Mays, MZ ShukittHale, B Chinn, KSK Tharion, WJ AF Lieberman, HR Mays, MZ ShukittHale, B Chinn, KSK Tharion, WJ TI Effects of sleeping in a chemical protective mask on sleep quality and cognitive performance SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID DISRUPTION; SYMPTOMS; DEPRIVATION; TYROSINE; STRESS; MOODS AB Purpose: We wanted to determine whether sleep is disrupted when soldiers sleep in a new chemical protective mask, the M40. Sleep quantity and quality, extent of protection provided by the mask during sleep, and next day performance were assessed. Method: After several days of training, 9 male soldiers slept with and without the M40 mask on four occasions. Results: Soldiers were able to tolerate the mask for most or all of the night. However, sleep, as assessed by wrist-worn activity monitors, was significantly disturbed. Minutes (mean +/- SEM) of waking significantly increased, from 25 +/- 2.1 to 86 +/- 8.5 per night (p < 0.001), and number of awakenings rose from 8 +/- 0.6 to 20 +/- 0.9 (p < 0.0001). Soldiers reported that it took longer and was more difficult to fall asleep when wearing the mask. Errors on a choice reaction time task increased significantly and subjects reported greater fatigue and sleepiness the day after sleeping in the mask. Protection provided by the masks varied substantially among subjects and declined over the course of the study. Some soldiers were protected throughout the night but others were only protected intermittently. Conclusion: We conclude that sleeping in the chemical protective mask should only be done when necessary, given the adverse effects on sleep and daytime function, as well as the variability of protection, of the mask. C1 USA,ENVIRONM MED RES INST,MIL PERFORMANCE & NEUROSCI DIV,OCCUPAT HLTH & PERFORMANCE DIRECTORATE,NATICK,MA 01760. GEOCENTERS INC,NEWTON,MA. NR 32 TC 10 Z9 10 U1 1 U2 3 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD SEP PY 1996 VL 67 IS 9 BP 841 EP 848 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA VF795 UT WOS:A1996VF79500004 PM 9025799 ER PT J AU Gamble, WB Bonnecarre, ER AF Gamble, WB Bonnecarre, ER TI Coffee, tea, or frostbite? A case report of inflight freezing hazard from dry ice SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID INJURIES AB Occupational and recreational cold exposure is fairly well described in the literature. This is a case report of a passenger on a commercial airline flight who suffered third degree frostbite due to the attempted therapeutic use of a cold pack. This cold pack was offered by the flight attendant and consisted of a section of dry ice used for cooling in the galley. The resulting injury consisted of a full thickness cold injury of the left lumbar amounting to approximately 1.5% TBSA (total body surface area). The occurrence of third degree frostbite due to a medicinally used ice pack such as this has not been noted in the past writings. The resulting injury, care and outcome of such an injury are described and discussed. C1 WALTER REED ARMY MED CTR,PLAST & RECONSTRUCT SURG SERV,WASHINGTON,DC 20307. NR 10 TC 6 Z9 6 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD SEP PY 1996 VL 67 IS 9 BP 880 EP 881 PG 2 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA VF795 UT WOS:A1996VF79500012 PM 9025807 ER PT J AU Zbilut, JP Zak, M Meyers, RE AF Zbilut, JP Zak, M Meyers, RE TI A terminal dynamics model of the heartbeat SO BIOLOGICAL CYBERNETICS LA English DT Article ID RATE-VARIABILITY; CHAOS; NOISE AB It is widely assumed that heartbeat dynamics are chaotic, although there has been no evidence confirming such an opinion, and some evidence to the contrary. Additionally, the deterministic assumptions of such dynamics cannot be demonstrated. An alternative model is presented based upon the notion of terminal dynamics, which can more faithfully represent key features of the heartbeat: namely, piecewise determinism, and singular points between beats, which allow for adaptability while maintaining stability. C1 CALTECH,JET PROP LAB,PASADENA,CA 91105. USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP Zbilut, JP (reprint author), RUSH UNIV,DEPT MOL BIOPHYS & PHYSIOL,1653 W CONGRESS,CHICAGO,IL 60612, USA. NR 36 TC 16 Z9 16 U1 0 U2 1 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0340-1200 J9 BIOL CYBERN JI Biol. Cybern. PD SEP PY 1996 VL 75 IS 3 BP 277 EP 280 DI 10.1007/s004220050294 PG 4 WC Computer Science, Cybernetics; Neurosciences SC Computer Science; Neurosciences & Neurology GA VN764 UT WOS:A1996VN76400009 PM 8900041 ER PT J AU Li, RS Chen, XW Gong, BQ Selzer, PM Li, Z Davidson, E Kurzban, G Miller, RE Nuzum, EO McKerrow, JH Fletterick, RJ Gillmor, SA Craik, CS Kuntz, ID Cohen, FE Kenyon, GL AF Li, RS Chen, XW Gong, BQ Selzer, PM Li, Z Davidson, E Kurzban, G Miller, RE Nuzum, EO McKerrow, JH Fletterick, RJ Gillmor, SA Craik, CS Kuntz, ID Cohen, FE Kenyon, GL TI Structure-based design of parasitic protease inhibitors SO BIOORGANIC & MEDICINAL CHEMISTRY LA English DT Article ID PURINE NUCLEOSIDE PHOSPHORYLASE; RATIONAL DESIGN; DRUG DESIGN; 9-DEAZAGUANINE; DERIVATIVES; DISCOVERY; DISEASE; POTENT AB To streamline the preclinical phase of pharmaceutical development, we have explored the utility of structural data on the molecular target and synergy between computational and medicinal chemistry. We have concentrated on parasitic infectious diseases with a particular emphasis on the development of specific noncovalent inhibitors of proteases that play a key role in the parasites' life cycles. Frequently, the structure of the enzyme target of pharmaceutical interest is not available. In this setting we have modeled the structure of the relevant enzyme by virtue of its sequence similarity with proteins of known structure. For example, we have constructed a homology-based model of falcipain, the trophozoite cysteine protease, and used the computational ligand identification algorithm DOCK to identify in compuo enzyme inhibitors including oxalic bis(2-hydroxy-1-naphthylmethylene)hydrazide (1) [Ring, C. S.; Sun, E.; McKerow, J. H.; Lee, G.; Rosenthal, P. J., Kuntz, I. D.; Cohen, F. E., Proc. Natl Acad. Sci. U.S.A. 1993, 90, 3583]. Compound 1 inhibits falcipain (IC50 6 mu M) and the organism in vitro as judged by hypoxanthine uptake (IC50 7 mu M). Following this lead, to date, we have identified potent bis arylacylhydrazides (IC50 150 nM) and chalcones (IC50 200 nM) that are active against both chloroquine-sensitive and chloroquine-resistant strains of malaria. In a second example, cruzain, the crystallographically determined structure of a papain-like cysteine protease, resolved to 2.35 Angstrom, was available. Aided by DOCK, we have identified a family of bis-arylacylhydrazides that are potent inhibitors of cruzain (IC50 600 mu M) These compounds represent useful leads for pharmaceutical development over strict enzyme inhibition criteria in a structure; based design program. Copyright (C) 1996 Elsevier Science Ltd C1 UNIV CALIF SAN FRANCISCO,DEPT PHARMACEUT CHEM,SAN FRANCISCO,CA 94143. UNIV CALIF SAN FRANCISCO,DEPT PATHOL,VET AFFAIRS MED CTR,SAN FRANCISCO,CA 94143. UNIV CALIF SAN FRANCISCO,DEPT BIOPHYS & BIOCHEM,SAN FRANCISCO,CA 94143. UNIV CALIF SAN FRANCISCO,DEPT MED & PHARMACOL,SAN FRANCISCO,CA 94143. GEORGETOWN UNIV,DEPT BIOCHEM & MOL BIOL,WASHINGTON,DC 20007. WALTER REED ARMY INST RES,DIV EXPT THERAPEUT,WASHINGTON,DC 20307. FU NIAID NIH HHS [P01 AI 35707] NR 25 TC 85 Z9 88 U1 2 U2 14 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0968-0896 J9 BIOORGAN MED CHEM JI Bioorg. Med. Chem. PD SEP PY 1996 VL 4 IS 9 BP 1421 EP 1427 DI 10.1016/0968-0896(96)00136-8 PG 7 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry, Organic SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA VL856 UT WOS:A1996VL85600005 PM 8894100 ER PT J AU Evans, CP Gajendran, V Tewari, A Aslam, K Juster, R Gange, S Eason, A Narayan, P AF Evans, CP Gajendran, V Tewari, A Aslam, K Juster, R Gange, S Eason, A Narayan, P TI The proportional decrease in prostate specific antigen level best predicts the duration of survival after hormonal therapy in patients with metastatic carcinoma of the prostate SO BRITISH JOURNAL OF UROLOGY LA English DT Article DE cancer of the prostate; PSA; metastasis; hormonal therapy; monitoring; recurrence ID PROGNOSTIC-SIGNIFICANCE; CANCER; DISEASE; ADENOCARCINOMA AB Objective To examine the usefulness of a test for prostate specific antigen (PSA) to predict survival in hormonally treated patients with metastatic prostate cancer, Patients and methods The study comprised 49 patients (mean age 72 years, SD 6) who underwent orchidectomy for metastatic prostate cancer. PSA was measured before orchidectomy and after 6 months, and the absolute, differential and proportional decreases calculated, A Cox proportional hazards regression model, which controlled for patient age, tumour (Gleason) grade and the number of skeletal metastases, was then used to evaluate these estimates of PSA as predictors of survival. Results The 6-month proportional decrease in PSA from the pre-operative level was the most accurate predictor of patient survival (P = 0.006) after hormonal therapy for metastatic prostate cancer, Conclusion This information may help to direct appropriate patients to new and experimental therapies for metastatic disease. C1 UNIV FLORIDA,DEPT UROL,GAINESVILLE,FL. VET ADM MED CTR,SURG SERV,GAINESVILLE,FL. UNIV CALIF SAN FRANCISCO,DEPT SURG,SAN FRANCISCO,CA 94143. KAISER PERMANENTE MED CTR,SAN RAFAEL,CA. TRIPLER ARMY MED CTR,HI,SAN RAFAEL,CA. NR 18 TC 9 Z9 9 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0007-1331 J9 BRIT J UROL JI Br. J. Urol. PD SEP PY 1996 VL 78 IS 3 BP 426 EP 431 DI 10.1046/j.1464-410X.1996.00079.x PG 6 WC Urology & Nephrology SC Urology & Nephrology GA VF047 UT WOS:A1996VF04700019 PM 8881955 ER PT J AU Carter, AJ Hicks, K Heldman, AW Resar, JR Laird, JR Coombs, VJ Brinker, JA Blumenthal, RS AF Carter, AJ Hicks, K Heldman, AW Resar, JR Laird, JR Coombs, VJ Brinker, JA Blumenthal, RS TI Clinical evaluation of a microsample coagulation analyzer, and comparison with existing techniques SO CATHETERIZATION AND CARDIOVASCULAR DIAGNOSIS LA English DT Article DE PTCA; heparin; anticoagulation ID TRANSLUMINAL CORONARY ANGIOPLASTY; TIME; BEDSIDE AB A new microsample coagulation analyzer (Hemochron(R) Jr.) has recently been developed which performs a modified activated clotting time (ACT+) and an aPTT by using different reagents. The Hemochron(R) Jr. measures the clotting time of a 5-microliter whole-blood sample by an optical detector and extrapolates the results to the activated clotting time (ACT+) or the plasma-activated partial thromboplastin time by using a validated regression analysis. We compared 124 simultaneous ACT+ and Hemochron(R) ACTs, and 53 paired Hemochron(R) dr. aPTTs and hospital laboratory aPTTs, in 44 patients during coronary intervention. The Hemochron(R) Jr. aPTT closely correlated with the lab aPTT (r = .79, P < .0001), and the test results were available much more rapidly than the lab aPTT (3.5 +/- 1.1 vs. 58.3 +/- 25.5 min, P = 0.0029). A comparison of duplicate ACT+ measurements did not identify a significant difference in the means (292 +/- 115 sec vs. 293 +/- 112 sec, P = 0.72). The ACT+ closely correlated with the Hemochrom(R) ACTs (r = .85, P < .0001). At baseline, the mean ACT+ (175 +/- 43 sec) exceeded the Hemochron(R) ACT (144 +/- 36 sec) by 22% (P < .001). After heparin administration, the mean ACT+ (378 +/- 74 sec) exceeded the Hemochron(R) ACT (332 +/- 65) by 12% (P < .001). The Hemochron(R) Jr. provides a fast and reproducible methodology for measuring ACT and aPTT, using a small blood volume. Further studies are required to determine the optimal anticoagulation range when using the Hemochron(R) Jr. during or after interventional procedures. (C) 1996 Wiley-Liss, Inc. C1 JOHNS HOPKINS UNIV,BALTIMORE,MD. RP Carter, AJ (reprint author), WALTER REED ARMY MED CTR,SERV CARDIOL,ROOM 4A,WASHINGTON,DC 20307, USA. RI Heldman, Alan/K-8784-2012 NR 13 TC 7 Z9 7 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0098-6569 J9 CATHETER CARDIO DIAG JI Catheter. Cardiovasc. Diagn. PD SEP PY 1996 VL 39 IS 1 BP 97 EP 102 DI 10.1002/(SICI)1097-0304(199609)39:1<97::AID-CCD22>3.0.CO;2-K PG 6 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA VE515 UT WOS:A1996VE51500023 PM 8874958 ER PT J AU Cardello, AV AF Cardello, AV TI Role of the human senses in food behavior .3. Taste SO CEREAL FOODS WORLD LA English DT Article RP Cardello, AV (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CEREAL CHEMISTS PI ST PAUL PA 3340 PILOT KNOB RD, ST PAUL, MN 55121-2097 SN 0146-6283 J9 CEREAL FOOD WORLD JI Cereal Foods World PD SEP PY 1996 VL 41 IS 9 BP 751 EP 753 PG 3 WC Food Science & Technology SC Food Science & Technology GA VH108 UT WOS:A1996VH10800007 ER PT J AU Nestler, J Ploskey, G AF Nestler, J Ploskey, G TI Sound way to save fish SO CIVIL ENGINEERING LA English DT Article RP Nestler, J (reprint author), USA,CORPS ENGINEERS,WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 0 TC 1 Z9 1 U1 1 U2 2 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0885-7024 J9 CIVIL ENG JI Civil Eng. PD SEP PY 1996 VL 66 IS 9 BP 58 EP 61 PG 4 WC Engineering, Civil SC Engineering GA VE536 UT WOS:A1996VE53600033 ER PT J AU Hartman, AB VanDeVerg, LL Mainhart, CR Tall, BD SmithGill, SJ AF Hartman, AB VanDeVerg, LL Mainhart, CR Tall, BD SmithGill, SJ TI Specificity of monoclonal antibodies elicited by mucosal infection of BALB/c mice with virulent Shigella flexneri 2a SO CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY LA English DT Article ID EVOKE KERATOCONJUNCTIVITIS; ESCHERICHIA-COLI; CLONES BINDING; GUINEA-PIGS; ANTIGENS; VACCINE; PROTECTION; EPITOPE; SONNEI; LIPOPOLYSACCHARIDES AB Protective immunity against shigellosis is thought to be determined by the O-antigen side chains of the lipopolysaccharide (LPS) molecule, To study possible common protective epitopes, monoclonal antibodies reacting with Shigella flexneri 2a LPS were generated from BALB/c mice infected ocularly with the virulent serotype 2a strain S. flexneri 2457T and tested against a panel of S. flexneri LPSs by enzyme-linked immunosorbent and immunoblot assays, Four monoclonal antibodies were identified, all of which showed restricted specificity patterns. Three different patterns of reactivity to LPS possessing the 3,4 group antigen were seen: (i) 2a only, (ii) 2a and 5a, and (iii) 2a, 4a, 5a, and Y. These results have implications for designing a Shigella vaccine that will be protective against related serotypes. Electron microscopy studies showed that the monoclonal antibodies bind to the bacterial surface in a patchy pattern, suggesting their potential use for examining the LPS distribution on the sun-face of the bacteria. C1 NIH,GENET LAB,BETHESDA,MD 20892. US FDA,CTR FOOD SAFETY & APPL NUTR,WASHINGTON,DC 20204. RP Hartman, AB (reprint author), WALTER REED ARMY INST RES,DEPT ENTER INFECT,WASHINGTON,DC 20307, USA. OI Tall, Ben/0000-0003-0399-3629 NR 34 TC 7 Z9 7 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 1071-412X J9 CLIN DIAGN LAB IMMUN JI Clin. Diagn. Lab. Immunol. PD SEP PY 1996 VL 3 IS 5 BP 584 EP 589 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA VG961 UT WOS:A1996VG96100018 PM 8877140 ER PT J AU Berman, JD AF Berman, JD TI Treatment of New World cutaneous and mucosal leishmaniases SO CLINICS IN DERMATOLOGY LA English DT Article ID SODIUM STIBOGLUCONATE PENTOSTAM; MEGLUMINE ANTIMONATE; EFFICACY; KETOCONAZOLE; GUATEMALA; TRIAL RP Berman, JD (reprint author), WALTER REED ARMY INST RES,WASHINGTON,DC 20307, USA. NR 16 TC 31 Z9 34 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0738-081X J9 CLIN DERMATOL JI Clin. Dermatol. PD SEP-OCT PY 1996 VL 14 IS 5 BP 519 EP 522 DI 10.1016/0738-081X(96)00048-X PG 4 WC Dermatology SC Dermatology GA VJ946 UT WOS:A1996VJ94600012 PM 8889330 ER PT J AU Chung, MJ Carmichael, L Dukes, M AF Chung, MJ Carmichael, L Dukes, M TI Managing a RASSP design process: A mid-program review SO COMPUTERS IN INDUSTRY LA English DT Article DE RASSP; design and manufacturing of signal processors; electronic design environment; environment and methodology management AB The Rapid Prototyping of Application Specific Signal Processor (RASSP) Program is a four-year effort initiated by the US Department of Defense to effect the timely design and manufacturing of signal processors. An effective electronic design environment is considered to be among the critical RASSP technologies to achieve a four times improvement in the development cycle of complex digital systems. How well the environment manages processes and design data will effect the success of the environment in supporting computer assisted design and development of digital system. This paper discusses the requirements for such an environment and methodology management. One approach taken by RASSP is presented and analyzed using the established functional requirements as the metric. Finally, the limitations of the approach and areas which require further research are discussed. C1 USA,RES LAB,FT MONMOUTH,NJ. RP Chung, MJ (reprint author), MICHIGAN STATE UNIV,DEPT COMP SCI,A709 WELLS HALL,E LANSING,MI 48824, USA. NR 17 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3615 J9 COMPUT IND JI Comput. Ind. PD SEP 1 PY 1996 VL 30 IS 1 BP 49 EP 61 DI 10.1016/0166-3615(96)00019-X PG 13 WC Computer Science, Interdisciplinary Applications SC Computer Science GA VE501 UT WOS:A1996VE50100006 ER PT J AU Vinson, RP Keller, RA Keeling, JH AF Vinson, RP Keller, RA Keeling, JH TI Cutaneous herpes simplex virus, type I, in association with Staphylococcus aureus in an infant SO CUTIS LA English DT Article ID MICROBIAL SYNERGISM; HUMAN INFECTIONS AB A 9-month-old infant was diagnosed as having impetigo of the central face. Her clinical condition deteriorated despite treatment with intravenous antibiotics. Viral and bacterial cultures grew herpes simplex virus type I and Staphylococcus aureus, respectively. The patient's condition improved rapidly with antiviral treatment in combination with antibiotics. Recognition of the possibility of a combined viral and bacterial infection is important so that adequate treatment is not delayed. C1 BROOKE ARMY MED CTR,DERMATOL SERV,FT SAM HOUSTON,TX 78234. NR 17 TC 2 Z9 2 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0011-4162 J9 CUTIS JI Cutis PD SEP PY 1996 VL 58 IS 3 BP 227 EP 229 PG 3 WC Dermatology SC Dermatology GA VH443 UT WOS:A1996VH44300007 PM 8886538 ER PT J AU DeSilva, IPD Fernando, HJS Eaton, F Hebert, D AF DeSilva, IPD Fernando, HJS Eaton, F Hebert, D TI Evolution of Kelvin-Helmholtz billows in nature and laboratory SO EARTH AND PLANETARY SCIENCE LETTERS LA English DT Article DE shear; turbulence; stratification; atmosphere; ocean waves ID STRATIFIED SHEAR FLOWS; SEASONAL THERMOCLINE; INTERNAL WAVES; LENGTH SCALES; TURBULENCE; INSTABILITY; STABILITY; FLUIDS; OVERTURNS; EQUATOR AB A mixing mechanism prevalent in natural flows is the formation and breakdown of vortical billows known as Kelvin-Helmholtz (K-H) instabilities. Here we present field examples of K-H billow occurrences in the atmosphere and oceans, Laboratory experiments aimed at studying certain key features of K-H billows are also discussed, wherein the billows were generated in a two-layer stratified tilt-tank, It is shown that small-scale turbulent mixing is present within billows from the early stages of their evolution, but mixing becomes intense and the billows are destroyed as they achieve a maximum height and initiate collapse at a non-dimensional time of Delta Ur/lambda approximate to 5, where Delta U is the velocity shear and lambda is the wavelength, When Ut/lambda < 5, the Thorpe scale L(T) and Ihe maximum Thorpe displacement (L(T))(max), normalized by the local billow height L(b), are independent of both the horizontal location within the billow and time with L(T)/L(b) approximate to (0.49 +/- 0.03) and (L(T))(max)/L(b) approximate to (0.89 +/- 0.02). After the collapse starts, however, the pertinent lengthscale ratios in the 'core' of the billow show values similar to those of fully developed turbulent patches, i.e., L(T)/L(b) approximate to (0.29 +/- 0.04) and (L(T))(max)/L(b) approximate to (0.68 +/- 0.04). The field observations were found to be in good agreement with laboratory-based predictions. C1 ARIZONA STATE UNIV,DEPT MECH & AEROSP ENGN,ENVIRONM FLUID DYNAM PROGRAM,TEMPE,AZ 85287. USA,RES LAB,WHITE SANDS MISSILE RANGE,WHITE SANDS MISSILE RANGE,NM 88002. UNIV RHODE ISL,GRAD SCH OCEANOG,KINGSTON,RI 02882. NR 43 TC 50 Z9 50 U1 1 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0012-821X J9 EARTH PLANET SC LETT JI Earth Planet. Sci. Lett. PD SEP PY 1996 VL 143 IS 1-4 BP 217 EP 231 DI 10.1016/0012-821X(96)00129-X PG 15 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA VN030 UT WOS:A1996VN03000018 ER PT J AU Glass, AR Kushner, J AF Glass, AR Kushner, J TI Obesity, nutrition, and the thyroid SO ENDOCRINOLOGIST LA English DT Review ID THYROTROPIN-RELEASING-HORMONE; RESTING METABOLIC-RATE; LOW-CALORIE DIET; ENERGY-EXPENDITURE; NITROGEN-BALANCE; REVERSE T3; PROLACTIN RESPONSES; SERUM THYROTROPIN; FUNCTION TESTS; TSH RESPONSE AB The concept that ''slow metabolism'' might contribute to obesity, coupled with the idea that thyroid dysfunction is a common cause of ''slow metabolism,'' has led to exploration of the relationship between obesity, nutrition, and thyroid function, the topic of this review. Some obese animals have low serum T-3 concentrations; conversely, some studies of obese humans have revealed high serum T-3 concentrations. Exaggerated responses of serum TSH following thyrotropin-releasing hormone (TRH) stimulation have also been noted in some human studies, possibly suggestive of thyroid hormone resistance. Thyroid function in humans and animals depends in a complex way on dietary content and composition. Hypothyroid individuals may have transient increases in body weight related to changes in fluid balance rather than adipose mass; long-term treatment of hypothyroidism with thyroid replacement in physiologic dosage has little effect on body weight. Hypothyroidism does not seem more common in the obese population than in the general population. In obese individuals, supplementation of weight reduction regimens with exogenous T-3 may accelerate body weight loss at the expense of excessive loss of lean body mass and other possible side effects. In conclusion, abnormalities of thyroid function that are noted in obese individuals are of uncertain clinical significance. Hypothyroidism is not a significant etiology of idiopathic obesity, and treatment of obesity with exogenous thyroid hormones is fraught with significant problems. C1 WALTER REED ARMY MED CTR,DEPT MED,SERV ENDOCRINOL,WASHINGTON,DC 20307. RI Biguzzi, Felipe/E-4724-2015 NR 128 TC 8 Z9 8 U1 2 U2 6 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1051-2144 J9 ENDOCRINOLOGIST JI Endocrinologist PD SEP PY 1996 VL 6 IS 5 BP 392 EP 403 DI 10.1097/00019616-199609000-00007 PG 12 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA VL813 UT WOS:A1996VL81300007 ER PT J AU Russo, M Ferry, R Kolodny, E Gillberg, C AF Russo, M Ferry, R Kolodny, E Gillberg, C TI Heller syndrome in a pre-school boy. Proposed medical evaluation and hypothesized pathogenesis SO EUROPEAN CHILD & ADOLESCENT PSYCHIATRY LA English DT Article DE Heller syndrome; disintegrative disorder of childhood; pervasive developmental disorder; autism ID FIBRILLARY ACIDIC PROTEIN; DISINTEGRATIVE DISORDER; PRION PROTEIN; AUTISM; CHILDHOOD; DISEASE; EXPRESSION; CHILDREN; GENE AB The case of a 6-year-old boy who developed childhood disintegrative disorder (Heller syndrome) at the age of 4 years is presented, and specifics of the neurologic evaluation are detailed. A table is provided suggesting the complete neurologic work-up with the potential findings for children presenting with signs and symptoms of deterioration. A hypothesis for the aetiology of Heller syndrome proposes that predisposing genetic factors when combined with an environmental stress result in the deposition of amyloid and the disruption of synaptic transmission during the deterioration period. Speculation that the deterioration may be self-limited by activation of an immune response is based upon earlier findings that interleukin 1 has been shown to be involved in the breakdown of amyloid precursor protein in humans. C1 NYU, MED CTR, DEPT PSYCHIAT, CHILD PSYCHIAT INPATIENT UNIT, NEW YORK, NY 10016 USA. WALTER REED ARMY INST RES, DIV NEUROPSYCHIAT, WASHINGTON, DC 20307 USA. NYU, MED CTR, DEPT NEUROL, NEW YORK, NY 10016 USA. ANNEDALS CLIN, CHILD NEUROPSYCHIAT CLIN, S-41345 GOTHENBURG, SWEDEN. NR 31 TC 8 Z9 8 U1 1 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1018-8827 EI 1435-165X J9 EUR CHILD ADOLES PSY JI Eur. Child Adolesc. Psych. PD SEP PY 1996 VL 5 IS 3 BP 172 EP 177 PG 6 WC Psychology, Developmental; Pediatrics; Psychiatry SC Psychology; Pediatrics; Psychiatry GA VN807 UT WOS:A1996VN80700007 PM 8908424 ER PT J AU Atwa, MA Smallridge, RC Burch, HB Gist, ID Lu, R AboHashem, EM ElKannishy, MH Burman, KD AF Atwa, MA Smallridge, RC Burch, HB Gist, ID Lu, R AboHashem, EM ElKannishy, MH Burman, KD TI Immunoglobulins from Graves' disease patients stimulate phospholipase A(2) and C systems in FRTL-5 and human thyroid cells SO EUROPEAN JOURNAL OF ENDOCRINOLOGY LA English DT Article ID CANINE KIDNEY-CELLS; THYROTROPIN RECEPTOR; POLYMORPHONUCLEAR NEUTROPHILS; SELECTIVE-INHIBITION; DEPENDENT PROCESSES; 2ND MESSENGERS; ACTIVATION; CALCIUM; RELEASE; PHOSPHOINOSITIDE AB We have studied the effects of immunoglobulin G from Graves' disease patients on phospholipase A(2) (PLA(2)) and C (PLC) systems in FRTL-5 and human thyroid cells. Immunoglobulin G (IgG) from Graves' disease patients stimulated arachidonic acid (AA) release in a time- and dose-dependent manner, In FRTL-5 thyroid cells, removal of external calcium had no significant effect on the IgG (20 mu g/ml)-induced AA release in FRTL-5 thyroid cells. U-73122 (3 mu mol/l), a PLC inhibitor, and quinacrine (100 mu mol/l) but not U-26384 (5 mu mol/l), PLA(2) inhibitors, blocked the IgG-induced (20 mu g/ml) AA release in FRTL-5 thyroid cells. Immunoglobulin G (100 mu g/ml) also stimulated accumulation of inositol-1,4,5-triphosphate (IP3) in a time- and dose-dependent (20-300 mu g/ml) manner in FRTL-5 cells. Immunoglobulin G from Graves' disease patients induced a significant increase of IP3 production (p=0.01) compared to IgG from normal subjects, Removal of external calcium had no significant effect on the IgG-induced IP3 production. The PLC inhibitor U-73122 completely blocked IgG-induced IP3 production from FRTL-5 thyroid cells. Also, in human thyroid cells, IgG from Graves' disease patients induced a significant increase of AA release (p=0.001) and IP3 production (p=0.004) compared to the IgG from normal subjects. These data indicate that IgG from Graves' disease patients induced PLA(2) activity that was PLC dependent, a pattern referred to as sequential activation. Our studies suggest that IgG from Graves' disease patients activates PLA(2) and PLC systems in FRTL-5 and human thyroid cells. These signal transduction pathways could be involved in the pathogenesis of Graves' disease and future studies are warranted to investigate this area. C1 WASHINGTON HOSP CTR,ENDOCRINE SECT,MEDLANT RES INST,WASHINGTON,DC 20010. GEORGE WASHINGTON UNIV,MED CTR,DIV ENDOCRINOL,WASHINGTON,DC 20037. WALTER REED ARMY INST RES,DEPT CLIN PHYSIOL,WASHINGTON,DC. WALTER REED ARMY INST RES,DIV MED,WASHINGTON,DC. WALTER REED ARMY MED CTR,KYLE METAB UNIT,ENDOCRINE METAB SERV,WASHINGTON,DC 20307. MANSOURA UNIV,DEPT CLIN PATHOL,MANSOURA,EGYPT. NR 42 TC 8 Z9 9 U1 0 U2 0 PU SCANDINAVIAN UNIVERSITY PRESS PI OSLO PA PO BOX 2959 TOYEN, JOURNAL DIVISION CUSTOMER SERVICE, N-0608 OSLO, NORWAY SN 0804-4643 J9 EUR J ENDOCRINOL JI Eur. J. Endocrinol. PD SEP PY 1996 VL 135 IS 3 BP 322 EP 327 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA VN031 UT WOS:A1996VN03100011 PM 8890723 ER PT J AU Neary, PC AF Neary, PC TI It does take a hero SO FOREIGN AFFAIRS LA English DT Letter RP Neary, PC (reprint author), USA,OFF DEPUTY CHIEF STAFF INTELLIGENCE,WASHINGTON,DC 20310, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU COUNC FOREIGN RELAT INC PI NEW YORK PA 58 E 68TH ST, NEW YORK, NY 10021 SN 0015-7120 J9 FOREIGN AFF JI Foreign Aff. PD SEP-OCT PY 1996 VL 75 IS 5 BP 169 EP 170 DI 10.2307/20047815 PG 2 WC International Relations SC International Relations GA VE267 UT WOS:A1996VE26700081 ER PT J AU Kadakia, SC Angueira, CE Ward, JA Moore, M AF Kadakia, SC Angueira, CE Ward, JA Moore, M TI Gastrointestinal endoscopy in patients taking antiplatelet agents and anticoagulants: Survey of ASGE members SO GASTROINTESTINAL ENDOSCOPY LA English DT Article ID NONSTEROIDAL ANTIINFLAMMATORY DRUGS; LOW-DOSE ASPIRIN; BYPASS-SURGERY; BLOOD-LOSS; THERAPY; COMPLICATIONS; HEMORRHAGE; MIGRAINE; INCREASE; PLACEBO AB Background: Gastrointestinal endoscopy is often required in patients taking aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), or anticoagulants. Because proper guidelines are lacking, we believe that most endoscopists use their own criteria and judgment for stopping and restarting these agents during the periendoscopic period, and the practice varies widely. The aim of our study was to identify these practices among ASGE members. Methods: Questionnaires, each containing 22 questions with 157 responses, were sent to 3300 ASGE members, including all Gastroenterology Fellowship Program Directors. One thousand two hundred sixty-nine questionnaires were received and analyzed. Results: Physicians stopped aspirin and NSAIDs more frequently before colonoscopy (81%) and ERCP (79%) than before upper endoscopy (51%) (p < 0.001). Ninety percent of physicians stopped aspirin and NSAIDs for 10 or fewer days. Only 20% of physicians performed sphincterotomy when aspirin and NSAIDs were not stopped compared with 88% and 85% (p < 0.001 for both) of physicians performing cold biopsies at esophagogastroduodenoscopy and colonoscopy, respectively, and 77% and 69% performing hot biopsies for the same procedures (p < 0.001 for all compared with sphincterotomy). Depending on the indication for anticoagulation, 51% to 60% of physicians stopped warfarin before upper endoscopy; 71% to 82% before colonoscopy; and 26% to 51% of physicians used a ''heparin window.'' All physicians restarted warfarin immediately after diagnostic endoscopy, whereas 80% restarted it 7 or fewer days after therapeutic endoscopy. Conclusions: We conclude that a wide variation exists regarding the management of aspirin, NSAIDs, and anticoagulants in the periendoscopic period. There is a definite need for a consensus statement or guidelines for managing patients taking these agents. C1 BROOKE ARMY MED CTR,DEPT MED,SAN ANTONIO,TX 78234. BROOKE ARMY MED CTR,DEPT CLIN INVEST,SAN ANTONIO,TX 78234. RP Kadakia, SC (reprint author), BROOKE ARMY MED CTR,GASTROENTEROL SERV,SAN ANTONIO,TX 78234, USA. NR 46 TC 38 Z9 39 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD SEP PY 1996 VL 44 IS 3 BP 309 EP 316 DI 10.1016/S0016-5107(96)70170-0 PG 8 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA VH158 UT WOS:A1996VH15800016 PM 8885352 ER PT J AU McKay, DJ Acomb, LJ AF McKay, DJ Acomb, LJ TI Neutron moisture probe measurements of fluid displacement during in situ air sparging SO GROUND WATER MONITORING AND REMEDIATION LA English DT Article ID POROUS-MEDIA; 2-PHASE FLOW; PERMEABILITY; CONDUCTIVITY AB Strawberry Point, located on Hinchinbrook Island, Alaska, is the site of a Federal Aviation Administration air navigation facility that is contaminated with gasoline- and diesel-range hydrocarbons in soil and ground water. An air sparging system was installed to promote bioremediation in the zone of seasonal ground water fluctuation where the contaminant is concentrated. The sparge wells were placed in a homogeneous formation, consisting of fine-grain beach and eolian sands. The system was then evaluated to determine the ground water region of influence and optimum frequency of operation. Neutron probe borehole measurements of percentage of fluid displacement during sparging at two wells revealed dynamic air distributions defined by an initial and relatively rapid expansion phase followed by a consolidation phase. Air distribution was stable within 12 hours after startup, reaching a peak air saturation of greater than 50 percent. The radius of peak expansion varied with time and depth, with measurable fluid displacement occurring beyond 12 feet from the sparge well near the water table. The percentage of air saturation stabilized within one hour following cutoff of the air flow, leaving pockets of entrapped air near the water table. When air injection was resumed, air saturation levels were found to be repeatable. The observations at this site indicated that the effective region of influence is relatively small and that frequent pulsing is needed to optimize oxygen distribution. RP McKay, DJ (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 18 TC 16 Z9 16 U1 1 U2 2 PU GROUND WATER PUBLISHING CO PI WESTERVILLE PA 601 DEMPSEY RD, WESTERVILLE, OH 43081 SN 1069-3629 J9 GROUND WATER MONIT R JI Ground Water Monit. Remediat. PD FAL PY 1996 VL 16 IS 4 BP 86 EP 94 DI 10.1111/j.1745-6592.1996.tb01175.x PG 9 WC Water Resources SC Water Resources GA VU517 UT WOS:A1996VU51700009 ER PT J AU Riddle, WA AF Riddle, WA TI MacArthur's undercover war: Spies, saboteurs, guerrillas, and secret missions - Breuer,WB SO HISTORIAN LA English DT Book Review RP Riddle, WA (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU PHI ALPHA THETA PI ALLENTOWN PA THE HISTORIAN 50 COLLEGE DR, ALLENTOWN, PA 18104-6100 SN 0018-2370 J9 HISTORIAN JI Historian PD FAL PY 1996 VL 59 IS 1 BP 144 EP 145 PG 2 WC History SC History GA WD003 UT WOS:A1996WD00300018 ER PT J AU Riddle, WA AF Riddle, WA TI Three frontiers: Family, land, and society in the American West, 1850-1900 - May,DL SO HISTORICAL JOURNAL LA English DT Book Review RP Riddle, WA (reprint author), US MIL ACAD, W POINT, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0018-246X J9 HIST J JI Hist. J. PD SEP PY 1996 VL 39 IS 3 BP 827 EP 832 PG 6 WC History SC History GA VK453 UT WOS:A1996VK45300028 ER PT J AU Riddle, WA AF Riddle, WA TI Appalachia's path to dependency: Rethinking a region's economic history, 1730-1940 - Salstrom,P SO HISTORICAL JOURNAL LA English DT Book Review RP Riddle, WA (reprint author), US MIL ACAD, W POINT, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0018-246X J9 HIST J JI Hist. J. PD SEP PY 1996 VL 39 IS 3 BP 827 EP 832 PG 6 WC History SC History GA VK453 UT WOS:A1996VK45300026 ER PT J AU Riddle, WA AF Riddle, WA TI Crow dog's case: American Indian sovereignty, tribal law, and United States law in the nineteenth century - Harring,SL SO HISTORICAL JOURNAL LA English DT Book Review RP Riddle, WA (reprint author), US MIL ACAD, W POINT, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0018-246X J9 HIST J JI Hist. J. PD SEP PY 1996 VL 39 IS 3 BP 827 EP 832 PG 6 WC History SC History GA VK453 UT WOS:A1996VK45300027 ER PT J AU Alsop, WR Hawkins, ET Stelljes, ME Collins, W AF Alsop, WR Hawkins, ET Stelljes, ME Collins, W TI Comparison of modeled and measured tissue concentrations for ecological receptors SO HUMAN AND ECOLOGICAL RISK ASSESSMENT LA English DT Article DE ecological exposure assessment; lead; zinc; tissue concentrations; body burden ID RISK ASSESSMENT; SOIL INGESTION; SITES AB Measured soil concentrations are often used as input in ecological uptake models to estimate the concentrations of chemicals in various organisms. In this study, modeled and measured plant and animal concentrations were compared to evaluate the validity of various uptake modeling approaches for different groups of chemicals. The models used measured soil concentration data collected during a remedial investigation at an environmentally diverse Superfund site in California to estimate metal and organic chemical plant tissue concentrations. These modeled plant tissue concentrations were then used as intake concentrations to estimate tissue concentrations in herbivores, and the resulting modeled herbivore tissue concentrations were used as intake concentrations to estimate tissue concentrations in predators. Measured chemical concentrations were determined by collecting and chemically analyzing surface soil samples and collocated plants, so that soil concentrations and tissue concentrations could be correlated. Small mammals were also sampled at the sites, as close to the location of soil and plant collection as possible. These field data were then compared with modeled plant and animal tissue concentrations. For metals, the exposure models consistently overpredicted measured tissue concentrations for both plants and animals at high soil concentrations (those exceeding ''background'') and underpredicted tissue concentrations at low soil concentrations. In contrast, the measured dioxin concentrations in plants and animals were consistently greater than those predicted from the models across the range of detected soil concentrations, by approximately two orders of magnitude. C1 EMCON,SACRAMENTO,CA. USA,FT ORD,CA. RP Alsop, WR (reprint author), MCLAREN HART,CHEMRISK DIV,1135 ATLANTIC AVE,ALAMEDA,CA 94501, USA. NR 24 TC 7 Z9 9 U1 0 U2 2 PU CRC PRESS INC PI BOCA RATON PA 2000 CORPORATE BLVD NW, JOURNALS CUSTOMER SERVICE, BOCA RATON, FL 33431 SN 1080-7039 J9 HUM ECOL RISK ASSESS JI Hum. Ecol. Risk Assess. PD SEP PY 1996 VL 2 IS 3 BP 539 EP 557 PG 19 WC Biodiversity Conservation; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA WT986 UT WOS:A1996WT98600014 ER PT J AU DiDomizio, J Fish, C Moyer, L Glikerdas, P AF DiDomizio, J Fish, C Moyer, L Glikerdas, P TI FIREFINDER position analysis system advanced development model SO IEEE AEROSPACE AND ELECTRONIC SYSTEMS MAGAZINE LA English DT Article AB The FIREFINDER Position Analysis System (FFPAS) Advanced Development Model (ADM) is a computer tool that will facilitate the siting and set-up of the FIREFINDER AN/TPQ-36 Mortar Locating Radar and the AN/TPQ-37 Artillery Locating Radar. When properly sited, these radars are capable of detecting projectiles at ranges of several tens of kilometers and of determining the location of the weapon or launcher with high accuracy. A key element in the successful deployment of FIREFINDER is to ensure that there is adequate visibility of the radar's target (i.e., the projectile). The FIREFINDER must be able to observe a significant portion of the projectile's upward trajectory for all potential weapon firing positions and aim points. It is also important that the radar beams be optimally positioned above the intervening terrain to maximize the elevation coverage and minimize the ground clutter returns. C1 USA,COMMUN ELECT COMMAND,FT MONMOUTH,NJ 07733. RP DiDomizio, J (reprint author), TECHNOL SERV CORP,6515 MAIN ST,TRUMBULL,CT 06611, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-8985 J9 IEEE AERO EL SYS MAG JI IEEE Aerosp. Electron. Syst. Mag. PD SEP PY 1996 VL 11 IS 9 BP 25 EP 29 DI 10.1109/62.536801 PG 5 WC Engineering, Aerospace; Engineering, Electrical & Electronic SC Engineering GA VG286 UT WOS:A1996VG28600009 ER PT J AU Paquette, S AF Paquette, S TI 3D scanning in apparel design and human engineering SO IEEE COMPUTER GRAPHICS AND APPLICATIONS LA English DT Article RP Paquette, S (reprint author), USA,NATICK RES DEV & ENGN CTR,SOLDIER SYST COMMAND,NATICK,MA 01760, USA. NR 0 TC 44 Z9 48 U1 1 U2 10 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 SN 0272-1716 J9 IEEE COMPUT GRAPH JI IEEE Comput. Graph. Appl. PD SEP PY 1996 VL 16 IS 5 BP 11 EP 15 DI 10.1109/38.536269 PG 5 WC Computer Science, Software Engineering SC Computer Science GA VE324 UT WOS:A1996VE32400005 ER PT J AU Georges, JB Yeung, SP Cutrer, DM Wu, TC Lau, KY Lux, RA Chang, W AF Georges, JB Yeung, SP Cutrer, DM Wu, TC Lau, KY Lux, RA Chang, W TI Transmission of millimeter-wave signals using uncoated telecommunications-grade distributed feedback lasers SO IEEE PHOTONICS TECHNOLOGY LETTERS LA English DT Article ID MONOLITHIC SEMICONDUCTOR-LASERS; RESONANT MODULATION; FREQUENCIES; MODE AB Transmission of 2-Mb/s data at a subcarrier frequency of 35 GHz over 2.2 km of optical fiber by resonant modulation of an uncoated monolithic single-contact distributed feedback (DFB) laser is demonstrated. Modulation response, carrier-to-noise ratio and bit-error-rate results are reported, The tolerance of the resonant round-trip frequency to the DFB facet cleaving process and the device length uncertainty due to cleaving is also addressed in detail by computer simulation. C1 UNIV CALIF BERKELEY,DEPT EECS,BERKELEY,CA 94720. USA,RES LAB,AMSL,EP,EF,FT MONMOUTH,NJ 07703. NR 7 TC 0 Z9 0 U1 1 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 1041-1135 J9 IEEE PHOTONIC TECH L JI IEEE Photonics Technol. Lett. PD SEP PY 1996 VL 8 IS 9 BP 1270 EP 1272 DI 10.1109/68.531859 PG 3 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA VE155 UT WOS:A1996VE15500053 ER PT J AU Croisant, WJ Feickert, CA McInerney, MK AF Croisant, WJ Feickert, CA McInerney, MK TI A differential magnetic permeability model for pulsed magnetic field calculations SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT 1996 IEEE International Magnetics Conference (INTERMAG 96) CY APR 09-12, 1996 CL SEATTLE, WA SP IEEE AB Problems involving intense pulsed magnetic fields in soft ferromagnetic materials require the solution of nonlinear partial differential equations with a field-dependent relative differential permeability that must represent the major magnetic properties of the material oven. an extremely wide range of magnetic fields. With the assumption that hysteresis can be neglected, a simple mathematical model with two exponential terms is described in which four constants can be used to model the magnetic properties of interest in a given problem. The model is constrained to match the initial value, the maximum value, and the saturation flux density. The analysis presented here shows that there are limitations and that not all values of the magnetic properties can be accommodated simultaneously. RP Croisant, WJ (reprint author), USA,CONSTRUCT ENGN RES LAB,POB 9005,CHAMPAIGN,IL 61826, USA. NR 1 TC 1 Z9 2 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD SEP PY 1996 VL 32 IS 5 BP 4326 EP 4328 DI 10.1109/20.538858 PN 2 PG 3 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA VM259 UT WOS:A1996VM25900018 ER PT J AU Leupold, HA Potenziani, E Tilak, A AF Leupold, HA Potenziani, E Tilak, A TI Coaxial-hybrid-tron (CHIRON) type twisters SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT 1996 IEEE International Magnetics Conference (INTERMAG 96) CY APR 09-12, 1996 CL SEATTLE, WA SP IEEE ID FIELD SOURCES AB To obtain the high fields at short periods characteristic of CHIRON wiggler type free electron lasers (FELs), we have designed a circularly polarized radiation source or twister that operates on the same principle. As in the wiggler, the field sources are poles produced on surfaces of iron saturated by externally applied axial magnetic fields. Because of the much higher saturation magnetization of iron, the pole densities are greater than can appear on permanent magnet surfaces and therefore can produce higher magnetic fields. Such structures are compared to permanent magnet twisters with regard to field strength, bulk and ease of manufacture. RP Leupold, HA (reprint author), USA,RES LAB,PHYS SCI DIRECTORATE,DIV PHYS,FT MONMOUTH,NJ 07703, USA. NR 6 TC 0 Z9 0 U1 1 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD SEP PY 1996 VL 32 IS 5 BP 5076 EP 5078 DI 10.1109/20.539495 PN 2 PG 3 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA VM259 UT WOS:A1996VM25900256 ER PT J AU Leupold, HA Tilak, A Potenziani, E AF Leupold, HA Tilak, A Potenziani, E TI Doubly augmented magic spheres SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT 1996 IEEE International Magnetics Conference (INTERMAG 96) CY APR 09-12, 1996 CL SEATTLE, WA SP IEEE ID FIELD SOURCES AB Magic spheres augmented by both iron and permanent magnets can be constructed to simultaneously fill all of the stringent requirements for electron beam focusing in certain high-power radiation sources. Such structures are described and compared with unaugmented and singly augmented magic spheres with regard to field strength and uniformity, structural bulk, working volume and sufficient access to the working space. RP Leupold, HA (reprint author), USA,RES LAB,PHYS SCI DIRECTORATE,DIV PHYS,FT MONMOUTH,NJ 07703, USA. NR 3 TC 3 Z9 3 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD SEP PY 1996 VL 32 IS 5 BP 5079 EP 5081 DI 10.1109/20.539496 PN 2 PG 3 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA VM259 UT WOS:A1996VM25900257 ER PT J AU Casey, SD Sadler, BM AF Casey, SD Sadler, BM TI Modifications of the euclidean algorithm for isolating periodicities from a sparse set of noisy measurements SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article ID MISSING OBSERVATIONS; PARAMETER-ESTIMATION; SPECTRUM ANALYZER AB Modifications of the Euclidean algorithm are presented for determining the period from a sparse set of noisy measurements. The elements of the set are the noisy occurrence times of a periodic event with (perhaps very many) missing measurements. This problem arises in radar pulse repetition interval (PRI) analysis, in bit synchronization in communications, and in other scenarios. The proposed algorithms are computationally straightforward and converge quickly, A robust version is developed that is stable despite the presence of arbitrary outliers. The Euclidean algorithm approach is justified by a theorem that shows that, for a set of randomly chosen positive integers, the probability that they do not all share a common prime factor approaches one quickly as the cardinality of the set increases. In the noise-free case, this implies that the algorithm produces the correct answer with only 10 data samples, independent of the percentage of missing measurements, In the case of noisy data, simulation results show, for example, good estimation of the period from 100 data samples with 50% of the measurements missing and 25% of the data samples being arbitrary outliers. C1 UNIV MARYLAND,SYST RES INST,COLLEGE PK,MD 20742. USA,RES LAB,ADELPHI,MD 20783. RP Casey, SD (reprint author), AMERICAN UNIV,DEPT MATH & STAT,4400 MASSACHUSETTS AVE NW,WASHINGTON,DC 20016, USA. NR 35 TC 27 Z9 29 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 1053-587X J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD SEP PY 1996 VL 44 IS 9 BP 2260 EP 2272 DI 10.1109/78.536682 PG 13 WC Engineering, Electrical & Electronic SC Engineering GA VG698 UT WOS:A1996VG69800011 ER PT J AU Banerjee, S Premchandran, R Tata, M John, VT McPherson, GL Akkara, J Kaplan, D AF Banerjee, S Premchandran, R Tata, M John, VT McPherson, GL Akkara, J Kaplan, D TI Polymer precipitation using a micellar nonsolvent: The role of surfactant-polymer interactions and the development of a microencapsulation technique SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID ORGANOGELS; PEROXIDASE; MORPHOLOGY; PHENOLS; SYSTEMS AB Conjugated phenolic polymers are precipitated from solution using a nonsolvent system containing sodium bis(2-ethylhexyl)sulfosuccinate (AOT) reversed micelles. When contacted with nonpolar fluids, these polymers coil-up at low concentrations as a result of intramolecular hydrogen banding. Precipitation using a micellar nonsolvent results in highly dispersed polymeric particles whose internal voidage can be controlled by the water content of the micelles. Precipitation in such fluids also results in an encapsulation of intramicellar solutes (enzymes and/or ferrite nanoparticles), leading to the formation of microspherical composites with biocatalytic and/or magnetic properties. C1 TULANE UNIV,DEPT CHEM,NEW ORLEANS,LA 70118. USA,SOLDIER SYST COMMAND,NATICK RDE CTR,NATICK,MA 01760. RI John, Vijay/G-3747-2010 NR 20 TC 20 Z9 21 U1 0 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0888-5885 J9 IND ENG CHEM RES JI Ind. Eng. Chem. Res. PD SEP PY 1996 VL 35 IS 9 BP 3100 EP 3107 DI 10.1021/ie9507888 PG 8 WC Engineering, Chemical SC Engineering GA VF785 UT WOS:A1996VF78500035 ER PT J AU Burghaus, PA Wellde, BT Hall, T Richards, RL Egan, AF Riley, EM Ballou, WP Holder, AA AF Burghaus, PA Wellde, BT Hall, T Richards, RL Egan, AF Riley, EM Ballou, WP Holder, AA TI Immunization of Aotus nancymai with recombinant C terminus of Plasmodium falciparum merozoite surface protein 1 in liposomes and alum adjuvant does not induce protection against a challenge infection SO INFECTION AND IMMUNITY LA English DT Article ID HUMORAL IMMUNE-RESPONSES; MALARIA VACCINE; SACCHAROMYCES-CEREVISIAE; MONOCLONAL-ANTIBODIES; FRAGMENT; ANTIGEN; GROWTH; INHIBIT; TARGET; EXPRESSION AB Merozoite surface protein 1 (MSP-1) of Plasmodium falciparum is an antimalarial vaccine candidate, The highly conserved 19-kDa C-terminal processing fragment of MSP-1 (MSP-1(19)) is of particular interest since it contains epitopes recognized by monoclonal antibodies which inhibit the invasion of erythrocytes In vitro. The presence of naturally acquired anti-MSP-1(19) antibodies in individuals exposed to malaria has been correlated with reduced morbidity, and immunization with an equivalent recombinant P. yoelii antigen induces substantial protection against this parasite in mice. We have expressed P. falciparum MSP-1(19) in Escherichia coli as a correctly folded protein and immunized Aotus nancymai monkeys by using the protein incorporated into liposomes and adsorbed to alum. After vaccination, the sera from these animals contained anti-MSP-1(19) antibodies, some of which competed for binding to MSP-1(19) with monoclonal antibodies that inhibit parasite invasion of eryrthrocytes in vitro, However, after challenge with either a homologous or a heterologous strain of parasite, all animals became parasitemic and required treatment. The immunization did not induce protection in this animal model. C1 NATL INST MED RES,DIV PARASITOL,LONDON NW7 1AA,ENGLAND. UNIV EDINBURGH,INST CELL ANIM & POPULAT BIOL,DIV BIOL SCI,EDINBURGH EH9 3JN,MIDLOTHIAN,SCOTLAND. WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC. WALTER REED ARMY INST RES,DEPT MOL BIOCHEM,WASHINGTON,DC. RI Holder, Anthony/A-7554-2013; Riley, Eleanor/C-8960-2013 OI Holder, Anthony/0000-0002-8490-6058; Riley, Eleanor/0000-0003-3447-3570 FU Medical Research Council [MC_U117532067] NR 35 TC 42 Z9 44 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD SEP PY 1996 VL 64 IS 9 BP 3614 EP 3619 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA VE443 UT WOS:A1996VE44300026 PM 8751907 ER PT J AU Yamamoto, T Wakisaka, N Nakae, T Kamano, T Serichantalergs, O Echeverria, P AF Yamamoto, T Wakisaka, N Nakae, T Kamano, T Serichantalergs, O Echeverria, P TI Characterization of a novel hemagglutinin of diarrhea-associated Escherichia coli that has characteristics of diffusely adhering E-coli and enteroaggregative E-coli SO INFECTION AND IMMUNITY LA English DT Article ID HEP-2 CELLS; OUTER-MEMBRANE; DRUG-RESISTANCE; HELA-CELLS; AIDA-I; ADHERENCE; PATTERNS; ADHESIN; RECEPTOR; STRAINS AB Escherichia coli 73-1 (serotype O73:H33) and 5-2 (serotype O89:H-) isolated from patients with diarrhea adhered to tissue culture cells (HeLa and HEp-2) as well as coverslips (plastic and glass) in a diffuse pattern. Adherence of strain 73-1 was mediated by a 110-kbp plasmid designated pEDA1 and correlated with D-mannose-resistant hemagglutinin (MRHA) detected with bovine, sheep, or human erythrocytes. The MRHA region was duplicated on pEDA1 and mediated the production of the 57-kDa outer membrane protein whose N-terminal amino acid sequence was hydrophobic. In accordance with MRHA and adherence, the 57-kDa outer membrane protein was observed best at 37 degrees C and to a lesser extent at 25 degrees C. In human intestine, adherence to mucus and colonic epithelium was obvious. No detectable pill were observed. The enteroaggregative E. coli heat-stable enterotoxin 1 (EAST1) gene, whose nucleotide sequence was 99.1% homologous to that of enteroaggregative E. coli, was present adjacent to the MRHA region on pEDA1. Strain 5-2 also exhibited MRHA activities and adherence and had sequences corresponding to those of the MRHA region and EAST1 gene. The data suggest that strain 73-1 (and strain 5-2), which has characteristics of both diffusely adhering E. coli and enteroaggregative E. coli, possesses a novel hemagglutinin associated with diffuse adherence. C1 INT MED CTR JAPAN, RES INST, DEPT TROP MED, SHINJUKU KU, TOKYO, JAPAN. JUNTENDO UNIV, SCH MED, DEPT SURG 1, TOKYO 113, JAPAN. TOKAI UNIV, SCH MED, INST MED SCI, ISEHARA, KANAGAWA 25911, JAPAN. ARMED FORCES RES INST MED SCI, DEPT BACTERIOL IMMUNOL & MOL GENET, BANGKOK, THAILAND. RP Yamamoto, T (reprint author), INT MED CTR JAPAN, RES INST, DEPT INFECT DIS, SHINJUKU KU, 1-21-2 TOYAMA, TOKYO, JAPAN. NR 40 TC 23 Z9 23 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 EI 1098-5522 J9 INFECT IMMUN JI Infect. Immun. PD SEP PY 1996 VL 64 IS 9 BP 3694 EP 3702 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA VE443 UT WOS:A1996VE44300038 PM 8751919 ER PT J AU Tine, JA Lanar, DE Smith, DM Wellde, BT Schultheiss, P Ware, LA Kauffman, EB Wirtz, RA DeTaisne, C Hui, GSH Chang, SP Church, P Hollingdale, MR Kaslow, DC Hoffman, S Guito, KP Ballou, WR Sadoff, JC Paoletti, E AF Tine, JA Lanar, DE Smith, DM Wellde, BT Schultheiss, P Ware, LA Kauffman, EB Wirtz, RA DeTaisne, C Hui, GSH Chang, SP Church, P Hollingdale, MR Kaslow, DC Hoffman, S Guito, KP Ballou, WR Sadoff, JC Paoletti, E TI NYVAC-Pf7: A poxvirus-vectored, multiantigen, multistage vaccine candidate for Plasmodium falciparum malaria SO INFECTION AND IMMUNITY LA English DT Article ID GENETICALLY ENGINEERED POXVIRUSES; SPOROZOITE SURFACE PROTEIN-2; RECOMBINANT SERA PROTEIN; LETHAL JEV INFECTION; VIRUS GLYCOPROTEIN-D; ASEXUAL BLOOD STAGES; CIRCUMSPOROZOITE PROTEIN; PROTECTIVE IMMUNITY; AOTUS MONKEYS; ESCHERICHIA-COLI AB The highly attenuated NYVAC vaccinia virus strain has been utilized to develop a multiantigen, multistage vaccine candidate for malaria, a disease that remains a serious global health problem and for which no highly effective vaccine exists. Genes encoding seven Plasmodium falciparum antigens derived from the sporozoite (circumsporozoite protein and sporozoite surface protein 2), liver (liver stage antigen 1), blood (merozoite surface protein 1, serine repeat antigen, and apical membrane antigen 1), and sexual (25-kDa sexual-stage antigen) stages of the parasite life cycle were inserted into a single NYVAC genome to generate NYVAC-P17. Each of the seven antigens was expressed in NYVAC-Pf7-infected culture cells, and the genotypic and phenotypic stability of the recombinant virus was demonstrated. When inoculated into rhesus monkeys, NYVAC-Pf7 was safe and well tolerated. Antibodies that recognize sporozoites, liver, blood, and sexual stages of P. falciparum were elicited. Specific antibody responses against four of the P. falciparum antigens (circumsporozoite protein, sporozoite surface protein 2, merozoite surface protein 1, and 25-kDa sexual-stage antigen) were characterized. The results demonstrate that NYVAC-Pf7 is an appropriate candidate vaccine for further evaluation in human clinical trials. C1 VIROGENET CORP,TROY,NY 12180. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. PASTEUR MERIEUX SERUMS & VACCINS,F-69280 MARCY LETOILE,FRANCE. UNIV HAWAII,JOHN A BURNS SCH MED,DEPT TROP MED & MED MICROBIOL,HONOLULU,HI 96816. USN,MED RES INST,MALARIA PROGRAM,BETHESDA,MD 20889. UNIV LEEDS,DEPT BIOL,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND. NIAID,MALARIA RES LAB,BETHESDA,MD 20892. CONNAUGHT LABS INC,SWIFTWATER,PA 18370. RI Lanar, David/B-3560-2011 NR 95 TC 99 Z9 104 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD SEP PY 1996 VL 64 IS 9 BP 3833 EP 3844 PG 12 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA VE443 UT WOS:A1996VE44300055 PM 8751936 ER PT J AU Walsh, DS Thavichaigarn, P Dheeradhada, C Jiarakul, N Pearce, FC Wiesmann, WP Cioffi, WG Webster, HK AF Walsh, DS Thavichaigarn, P Dheeradhada, C Jiarakul, N Pearce, FC Wiesmann, WP Cioffi, WG Webster, HK TI Prolonged alteration in gut permeability following nonthermal injury SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED LA English DT Article ID INTESTINAL PERMEABILITY; CELIAC-DISEASE; BURN PATIENTS; TRAUMA; LACTULOSE; MANNITOL; BLUNT AB To assess the extent of intestinal permeability following nonthermal injury ratios of lactulose and mannitol (L-M) concentrations in urine following enteral administration were determined simultaneously by a gas-liquid chromatography assay on days 3, 5, 7, 10, and 13 in 15 patients with an Injury Severity Score >20. Thirteen of 15 patients recovered uneventfully and two developed minor infections. L-M ratios were significantly increased on days 3-10 (P < 0.05 vs controls). The data are consistent with previous studies describing early changes in gut permeability following nonthermal injury and show that altered permeability can persist for up to 10 days in patients with uneventful recoveries. Published by Elsevier Science Ltd. C1 USA,MED COMPONENT,DEPT IMMUNOL,ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. NR 14 TC 4 Z9 4 U1 0 U2 0 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0020-1383 J9 INJURY JI Injury-Int. J. Care Inj. PD SEP PY 1996 VL 27 IS 7 BP 491 EP 494 DI 10.1016/0020-1383(96)00055-1 PG 4 WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery GA VR521 UT WOS:A1996VR52100007 PM 8977835 ER PT J AU Finger, DR Dunn, CL Gilliland, WR James, WD AF Finger, DR Dunn, CL Gilliland, WR James, WD TI Amyopathic dermatomyositis associated with malignancy SO INTERNATIONAL JOURNAL OF DERMATOLOGY LA English DT Article ID CUTANEOUS CHANGES; SINE MYOSITIS; MUSCLE C1 WALTER REED ARMY MED CTR,DEPT RHEUMATOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT DERMATOL,WASHINGTON,DC 20307. NR 10 TC 11 Z9 11 U1 0 U2 0 PU DECKER PERIODICALS INC PI HAMILTON PA 4 HUGHSON STREET SOUTH PO BOX 620, LCD 1, HAMILTON ON L8N 3K7, CANADA SN 0011-9059 J9 INT J DERMATOL JI Int. J. Dermatol. PD SEP PY 1996 VL 35 IS 9 BP 663 EP 664 DI 10.1111/j.1365-4362.1996.tb03698.x PG 2 WC Dermatology SC Dermatology GA VF402 UT WOS:A1996VF40200018 PM 8876300 ER PT J AU Rajendran, AM Grove, DJ AF Rajendran, AM Grove, DJ TI Modeling the shock response of silicon carbide, boron carbide and titanium diboride SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE ceramic; modeling; shock; high strain rate; fracture; silicon carbide; titanium diboride; hydrocode ID ELASTIC-MODULI; SPALLATION; FRACTURE AB An advanced constitutive model is used to describe the shock and high strain rate behaviors of silicon carbide, boron carbide, and titanium diboride under impact loading conditions. The model's governing equations utilize a set of microphysically based constitutive relationships to describe the deformation and damage processes of ceramics. The total strain is decomposed into elastic, plastic, and microcracking components. The plastic strain components are calculated using conventional viscoplastic equations. The strain components due to microcracking utilize relationships derived from a penny shaped crack in an infinite elastic solid. The main features of the model include degradation of strength and stiffness under both compressive and tensile loading conditions. When loaded above the Hugoniot elastic limit (HEL), the strength is limited by the strain rate dependent strength equation. However, below the HEL, the strength variation with respect to strain rate and pressure is modeled through microcracking relationships, assuming no plastic flow. The ceramic model parameters were determined using plate impact experimental data. Copyright (C) 1996 Elsevier Science Ltd. RP Rajendran, AM (reprint author), USA,RES LAB,MAT DIRECTORATE,ABERDEEN PROVING GROUND,MD 21005, USA. RI Rajendran, Arunachalam/A-1615-2010 NR 19 TC 62 Z9 65 U1 4 U2 21 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD SEP PY 1996 VL 18 IS 6 BP 611 EP 631 DI 10.1016/0734-743X(96)89122-6 PG 21 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA UW270 UT WOS:A1996UW27000003 ER PT J AU Hicks, D Rundell, J AF Hicks, D Rundell, J TI HIV testing and counseling SO INTERNATIONAL REVIEW OF PSYCHIATRY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; SCREENING-PROGRAM; INFECTION; RISK; SUICIDE; AIDS AB Fifteen years into the epidemic, AIDS remains a frightening and life-threatening disease. Knowledge about the cause, natural history, treatments, and prognosis, has significantly increased longevity, but there is still no sign of a cure. Tie number of newly-infected persons continues to rise, despite concerted efforts at education and prevention. Our social and legal system have attempted to put in place structures to provide humane care, treatment and protection, but much ignorance and discrimination remain. Because of the life-threatening nature of the disease, and the psychological, social and legal ramifications, strategic HN testing and counseling are important safeguards. Pre-test counseling helps to educate those considering HIV testing about the real risks of HIV transmission, and reinforces behavior which can lead to risk reduction. For persons receiving news of a positive HIV test, post-test counseling provides a safe place to react to their diagnosis and to begin, hopefully, a healthy adjustment to their altered life. This article summarizes information psychiatrists and other clinicians need in order to provide the most effective counseling for those who seek and receive HIV testing. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PSYCHIAT,BETHESDA,MD 20814. RP Hicks, D (reprint author), WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20307, USA. NR 31 TC 2 Z9 2 U1 0 U2 0 PU CARFAX PUBL CO PI ABINGDON PA PO BOX 25, ABINGDON, OXFORDSHIRE, ENGLAND OX14 3UE SN 0954-0261 J9 INT REV PSYCHIATR JI Int. Rev. Psych. PD SEP PY 1996 VL 8 IS 2-3 BP 177 EP 184 DI 10.3109/09540269609046302 PG 8 WC Psychiatry SC Psychiatry GA VE805 UT WOS:A1996VE80500006 ER PT J AU Sandler, S AF Sandler, S TI Untitled SO JOURNAL OF AMERICAN HISTORY LA English DT Letter RP Sandler, S (reprint author), USA,CTR MIL HIST,WASHINGTON,DC 20310, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU ORGAN AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47401 SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD SEP PY 1996 VL 83 IS 2 BP 718 EP 718 PG 1 WC History SC History GA VH816 UT WOS:A1996VH81600171 ER PT J AU Yu, S Kim, KW Stroscio, MA Iafrate, GJ Ballato, A AF Yu, S Kim, KW Stroscio, MA Iafrate, GJ Ballato, A TI Electron interaction with confined acoustic phonons in cylindrical quantum wires via deformation potential SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID BRILLOUIN-SCATTERING; RAMAN-SCATTERING; FILMS; SUPERLATTICES; SYSTEMS; MODES; RATES AB The effects of phonon confinement on electron-acoustic-phonon scattering is studied in cylindrical semiconductor quantum wires. In the macroscopic elastic continuum model, the confined-phonon dispersion relations are obtained for several crystallographic directions with the two cardinal boundary conditions: free-surface and clamped-surface boundary conditions. The scattering rates due to the deformation potential interaction are obtained for these confined phonons and are compared with those of bulk-like phonons for a number of quantum wire materials. The results show that the inclusion of acoustic phonon confinement effects may be crucial for calculating accurate low-energy electron scattering rates in nanostructures. It is also demonstrated that the scattering rates may be significantly influenced by the direction of phonon propagation, especially for low-energy electrons. Furthermore, it has been found that there is a scaling rule governing the directional dependence of the scattering rates: the directions characterized by small Poisson ratios exhibit large scattering rates. (C) 1996 American Institute of Physics. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. USA,RES LAB,PHYS SCI DIRECTORATE,FT MONMOUTH,NJ 07703. N CAROLINA STATE UNIV,DEPT PHYS,RALEIGH,NC 27695. RP Yu, S (reprint author), N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695, USA. NR 21 TC 17 Z9 17 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 1 PY 1996 VL 80 IS 5 BP 2815 EP 2822 DI 10.1063/1.363199 PG 8 WC Physics, Applied SC Physics GA VE246 UT WOS:A1996VE24600036 ER PT J AU Sciuto, AM Stotts, RR Hurt, HH AF Sciuto, AM Stotts, RR Hurt, HH TI Efficacy of ibuprofen and pentoxifylline in the treatment of phosgene-induced acute lung injury SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE edema; ibuprofen; pentoxifylline; lung; toxic gas ID PULMONARY-EDEMA; TOXICITY; EXPOSURE; INVITRO; CAMP AB Phosgene, a highly reactive former warfare gas, is a deep lung irritant which produces adult respiratory distress syndrome (ARDS)-like symptoms following inhalation. Death caused by phosgene involves a latent, 6-24-h, fulminating non-cardiogenic pulmonary edema. The following dose-ranging study was designed to determine the efficacy of a non-steroidal anti-inflammatory drug, ibuprofen (IBU), and a methylxanthine, pentoxifylline (PTX). These drugs were tested singly and in combination to treat phosgene-induced acute lung injury in rats. Ibuprofen, in concentrations of 15-300 mg kg(-1) (i.p.), was administered to rats 30 min before and 1 h after the start of whole-body exposure to phosgene (80 mg m(-3) for 20 min). Pentoxifylline, 10-120 mg kg(-1) (i.p.), was first administered 15 min prior to phosgene exposure and twice more at 45 and 105 min after the start of exposure. Five hours after phosgene inhalation, rats were euthanized, the lungs were removed and wet weight values were determined gravimetrically. Ibuprofen administered alone significantly decreased lung wet weight to body weight ratios compared with controls (P less than or equal to 0.01) whereas PTX, at all doses tested alone, did not. In addition, the decrease in lung wet weight to body weight ratio observed with IBU+PTX could be attributed entirely to the dose of TSU employed. This is the first study to show that pre- and post-treatment with IBU can significantly reduce lung edema in rats exposed to phosgene. RP Sciuto, AM (reprint author), USA,MED RES INST CHEM DEF,DIV PATHOPHYSIOL,PHYSIOL BRANCH,ABERDEEN PROVING GROUND,ABERDEEN,MD 21010, USA. NR 33 TC 26 Z9 28 U1 2 U2 3 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD SEP-OCT PY 1996 VL 16 IS 5 BP 381 EP 384 DI 10.1002/(SICI)1099-1263(199609)16:5<381::AID-JAT355>3.0.CO;2-8 PG 4 WC Toxicology SC Toxicology GA VK205 UT WOS:A1996VK20500002 PM 8889788 ER PT J AU Karle, JM Bhattacharjee, AK AF Karle, JM Bhattacharjee, AK TI Trifluoromethyl group disorder in crystalline 2,8-bis(trifluoromethyl)-4-hydroxymethylquinoline SO JOURNAL OF CHEMICAL CRYSTALLOGRAPHY LA English DT Article DE disordered trifluoromethyl group; quinoline; crystal structure; AM1 calculation; mefloquine ID MOLECULAR-STRUCTURE AB The title compound crystallized in space group Pna2(1) with lattice constants a = 13.406(1), b = 18.799 (4), and c = 4.785(1). The molecule is essentially flat with only fluorine atoms, methylene hydrogen atoms, and the hydroxyl hydrogen atom out of the plane of the quinoline ring. Only one of the trifluoromethyl groups of the title compound is disordered following a pattern observed in other crystal structures. Quantum chemical calculations at the AM1 level are consistent with this phenomenon. Although the carbon atom of the fixed trifluoromethyl group is further from the quinoline nitrogen atom than the carbon atom of the disordered trifluoromethyl group, the fluorine atoms of the fixed trifluoromethyl group more closely approach the quinoline nitrogen atom by 0.3 Angstrom if the C(8)-C(10) bond in the crystal structure is freely rotated. C1 NATL RES COUNCIL,WASHINGTON,DC 20418. RP Karle, JM (reprint author), WALTER REED ARMY MED CTR,DEPT PHARMACOL,DIV EXPT THERAPEUT,WASHINGTON,DC 20307, USA. RI G, Neela/H-3016-2014 NR 8 TC 1 Z9 1 U1 0 U2 0 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 1074-1542 J9 J CHEM CRYSTALLOGR JI J. Chem. Crystallogr. PD SEP PY 1996 VL 26 IS 9 BP 615 EP 619 DI 10.1007/BF01668622 PG 5 WC Crystallography; Spectroscopy SC Crystallography; Spectroscopy GA VX842 UT WOS:A1996VX84200004 ER PT J AU Stevens, JB Shepherd, JM Vories, PA Walker, SC Vescovo, MV AF Stevens, JB Shepherd, JM Vories, PA Walker, SC Vescovo, MV TI A mixture of mivacurium and rocuronium is comparable in clinical onset to succinylcholine SO JOURNAL OF CLINICAL ANESTHESIA LA English DT Article DE intubation; mivacurium; rocuronium; succinylcholine; synergy ID NEUROMUSCULAR BLOCKADE; INTUBATING CONDITIONS; ADDUCTOR POLLICIS; ORG-9426; VECURONIUM; MUSCLES AB Study Objectives: To compare the clinical onset and duration of a combination of mivacurium and rocuronium with succinylcholine, and to determine the efficacy of this mixture for rapid tracheal intubation. Design: Observer-blind prospective study. Setting: Teaching hospital. Patients: 70 ASA status I and II patients having general anesthesia for elective surgery. Measurements and Main Results: After induction of general anesthesia patients randomly received succinylcholine 1.0 mg/kg, rocuronium 0.6 mg/kg or a combination of rocuronium 0.6 mg/kg and mivacurium 0.15 mg/kg. Evoked muscular response at the adductor pollicis was measured by mechanomyography. The time from injection of muscle relaxant(s) to ablation of T-1 (clinical onset) and recovery of T-1 to 25% of control height (clinical duration) was recorded. Intubating conditions 45 seconds after administration of muscle relaxants were assessed. There was no significant difference in clinical onset time between succinylcholine (mean +/- SD, 47.4 +/- 6.5 seconds) and the combination of mivacurium-rocuronium (51.2 +/- 13.4 seconds). Intubating conditions with mivacurium-rocuronium rocuronium were comparable to those of succinylcholine. The clinical duration of rocuronium 0.6 mg/kg (38.9 +/- 12.3 minutes) was prolonged by the addition of mivacurium (49.0 +/- 9.6 minutes). Conclusions: This combination of mivacurium and rocuronium is comparable to succinylcholine in both clinical onset time and quality of intubating conditions When rapid onset of dense neuromuscular blockade and intermediate clinical duration is desirable, this mixture may be an acceptable alternative to succinylcholine. RP Stevens, JB (reprint author), BROOKE ARMY MED CTR,DEPT ANESTHESIA,ANESTHESIA & OPERAT SERV,SAN ANTONIO,TX 78234, USA. NR 11 TC 9 Z9 10 U1 0 U2 0 PU BUTTERWORTH-HEINEMANN PI WOBURN PA 225 WILDWOOD AVE #UNITB PO BOX 4500, WOBURN, MA 01801-2084 SN 0952-8180 J9 J CLIN ANESTH JI J. Clin. Anesth. PD SEP PY 1996 VL 8 IS 6 BP 486 EP 490 DI 10.1016/0952-8180(96)00108-0 PG 5 WC Anesthesiology SC Anesthesiology GA VE130 UT WOS:A1996VE13000012 PM 8872689 ER PT J AU Houston, JR AF Houston, JR TI A discussion of the generalized model for simulating shoreline change (GENESIS) SO JOURNAL OF COASTAL RESEARCH LA English DT Editorial Material AB This paper discusses criticism by YOUNG ct al., 1995, of the GENESIS model. YOUNG et al., 1995, provide a single example (beach nourishment at Folly Beach, South Carolina) to support their claim that GENESIS fails in practical-engineering application. This discussion will show they neither provide evidence supporting their contention that the Folly Beach project is performing poorly nor evidence that GENESIS predictions used in project design are incorrect. Extensive monitoring of the Folly Beach project shows the project is performing as expected and that GENESIS predictions for the project were good. RP Houston, JR (reprint author), USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,VICKSBURG,MS 39180, USA. NR 5 TC 5 Z9 5 U1 0 U2 3 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD FAL PY 1996 VL 12 IS 4 BP 1038 EP 1043 PG 6 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA VX661 UT WOS:A1996VX66100031 ER PT J AU Strawn, RC Biswas, R Lyrintzis, AS AF Strawn, RC Biswas, R Lyrintzis, AS TI Helicopter noise predictions using Kirchhoff methods SO JOURNAL OF COMPUTATIONAL ACOUSTICS LA English DT Article ID BLADE-VORTEX INTERACTIONS; SPEED IMPULSIVE NOISE; ROTOR; HOVER AB This paper presents two methods for predicting the noise from helicopter rotors in forward flight. Aerodynamic and acoustic solutions in the near held are computed with a finite-difference solver for the Euler equations. Two different Kirchhoff acoustics methods are then used to propagate the acoustic signals to the far field in a computationally-efficient manner. One of the methods uses a Kirchhoff surface that rotates with the rotor blades. The other uses a nonrotating Kirchhoff surface. Results from both methods are compared to experimental data for both highspeed impulsive noise and blade-vortex interaction noise. Agreement between experimental data and computational results is excellent for both cases. The rotating and nonrotating Kirchhoff methods are also compared for accuracy and efficiency. Both offer high accuracy with reasonable computer resource requirements. The Kirchhoff integrations efficiently extend the near-field finite-difference results to predict the far field helicopter noise. C1 NASA,AMES RES CTR,RIACS,MOFFETT FIELD,CA 94035. PURDUE UNIV,SCH AERONAUT & ASTRONAUT,W LAFAYETTE,IN 47907. RP Strawn, RC (reprint author), USA,NASA,AMES RES CTR,AFDD,MOFFETT FIELD,CA 94035, USA. NR 27 TC 9 Z9 9 U1 0 U2 1 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA JOURNAL DEPT PO BOX 128 FARRER ROAD, SINGAPORE 9128, SINGAPORE SN 0218-396X J9 J COMPUT ACOUST JI J. Comput. Acoust. PD SEP PY 1996 VL 4 IS 3 BP 321 EP 339 DI 10.1142/S0218396X96000106 PG 19 WC Acoustics; Mathematics, Interdisciplinary Applications SC Acoustics; Mathematics GA VP303 UT WOS:A1996VP30300004 ER PT J AU Xiao, Q Kuppurao, S Yeckel, A Derby, JJ AF Xiao, Q Kuppurao, S Yeckel, A Derby, JJ TI On the effects of ampoule tilting during vertical Bridgman growth: Three-dimensional computations via a massively parallel, finite element method SO JOURNAL OF CRYSTAL GROWTH LA English DT Article ID BUOYANCY-DRIVEN CONVECTION; CADMIUM ZINC TELLURIDE; SINGLE-CRYSTAL CDTE; INTERFACE SHAPE; NUMERICAL-SIMULATION; HEAT-TRANSFER; DIRECTIONAL SOLIDIFICATION; STOCKBARGER TECHNIQUE; MELT; SEGREGATION AB Three-dimensional convection and asymmetric radial segregation, caused by ampoule tilting during the vertical Bridgman growth, are analyzed using a novel, massively parallel, finite element model. The growth of cadmium telluride with a dilute dopant is considered and found to be surprisingly sensitive to the amount of tilt - as little as one degree of misalignment of the ampoule axis from the gravitational vector produces a significant three-dimensional flow and a concomitant skewing of the dopant distribution along the surface of the growing solid. This indicates the need for precise ampoule axis alignment to ensure process reproducibility. Analysis of the dopant distribution along the solid-liquid interface of the tilted system reveals a surface region more uniform in dopant concentration than any corresponding region of the interface of the perfectly aligned system. For systems in which low radial segregation is very important, growth with an intentional axis offset may be beneficial. C1 UNIV MINNESOTA,DEPT CHEM ENGN,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,ARMY HPC RES CTR,MINNEAPOLIS,MN 55455. RI Derby, Jeffrey/B-9706-2009; OI Derby, Jeffrey/0000-0001-6418-2155 NR 49 TC 35 Z9 35 U1 0 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 J9 J CRYST GROWTH JI J. Cryst. Growth PD SEP PY 1996 VL 167 IS 1-2 BP 292 EP 304 DI 10.1016/0022-0248(96)00231-X PG 13 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA VN615 UT WOS:A1996VN61500037 ER PT J AU Uyeno, DS Lugo, A AF Uyeno, DS Lugo, A TI Dens evaginatus: A review SO JOURNAL OF DENTISTRY FOR CHILDREN LA English DT Review ID TALON CUSP; MANAGEMENT; INCISOR AB A review of the developmental dental anomaly, dans evaginatus, and a discussion of its clinical management is presented. Fracture or wear of the tubercle of dens evaginatus frequently results in pulp necrosis and early periapical infection, often prior to completion of root formation. Early recognition of this anomaly, followed by timely treatment can prevent the loss of pulp vitality in these teeth. Patients presenting with nonvital teeth and incomplete root development have been successfully treated by apexification followed by conventional endodontic therapy. RP Uyeno, DS (reprint author), USA,DENT ACTIV,FT HOOD,TX, USA. NR 40 TC 6 Z9 7 U1 0 U2 0 PU AMER SOC DENTISTRY CHILD PI CHICAGO PA 211 E CHICAGO AVE, CHICAGO, IL 60611 SN 0022-0353 J9 J DENT CHILD JI J. Dent. Child. PD SEP-OCT PY 1996 VL 63 IS 5 BP 328 EP & PG 6 WC Dentistry, Oral Surgery & Medicine; Pediatrics SC Dentistry, Oral Surgery & Medicine; Pediatrics GA VV542 UT WOS:A1996VV54200004 ER PT J AU Nagatani, SS Fisher, JG Hondrum, SO AF Nagatani, SS Fisher, JG Hondrum, SO TI Effect of heat treatment on stainless steel lingual arch appliances SO JOURNAL OF DENTISTRY FOR CHILDREN LA English DT Article AB This study evaluated the effect of heat treatment on 0.036 '' diameter stainless steel wire. Forty wires were bent into arch forms (20 experimental and 20 control). The arch width changes were measured and the forces generated were determined over an eight week period. Heat treatment resulted in immediate and significant expansion (P < 0.001) followed by stabilization of the arch width. The control wires continued to expand throughout the study. The force generated by the control group and experimental group expansion was capable of producing tooth movement. C1 USA,PEDIAT DENT RESIDENCY PROGRAM,FT GEORGE G MEADE,MD. WALTER REED ARMY MED CTR,PEDIAT DENT SERV,WASHINGTON,DC 20307. USA,APPL DENT SCI BRANCH,INST DENT RES,FT GEORGE G MEADE,MD. NR 8 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC DENTISTRY CHILD PI CHICAGO PA 211 E CHICAGO AVE, CHICAGO, IL 60611 SN 0022-0353 J9 J DENT CHILD JI J. Dent. Child. PD SEP-OCT PY 1996 VL 63 IS 5 BP 346 EP & PG 5 WC Dentistry, Oral Surgery & Medicine; Pediatrics SC Dentistry, Oral Surgery & Medicine; Pediatrics GA VV542 UT WOS:A1996VV54200008 ER PT J AU Kolb, RA Stekler, HO AF Kolb, RA Stekler, HO TI How well do analysts forecast interest rates? SO JOURNAL OF FORECASTING LA English DT Article DE interest rate forecasts; forecast evaluation; consensus forecast ID ECONOMIC FORECASTS; ACCURACY AB This paper examines interest rate forecasts made for the period 1982-90 and examines three issues: (1) Is there a general agreement among analysts about the level of interest rates six months in the future? (2) Are all the forecasters equally good? (3) Are the forecasts valuable to prospective users? We use distributions of the cross-sections of forecasts, Friedman's statistic for analysis of variance by rank, and tests of independence between forecasts and outcomes to examine these questions. We conclude that there usually was a consensus among analysts, that there was no significant difference in the ability to forecast short-term rates but there was a difference with respect to the long-term predictions, and that these forecasts were not significantly better than random walk forecasts. C1 GEORGE WASHINGTON UNIV,DEPT ECON,WASHINGTON,DC 20052. RP Kolb, RA (reprint author), US MIL ACAD,DEPT MATH,W POINT,NY 10996, USA. NR 18 TC 16 Z9 16 U1 0 U2 5 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0277-6693 J9 J FORECASTING JI J. Forecast. PD SEP PY 1996 VL 15 IS 5 BP 385 EP 394 DI 10.1002/(SICI)1099-131X(199609)15:5<385::AID-FOR627>3.0.CO;2-B PG 10 WC Economics; Management SC Business & Economics GA VN152 UT WOS:A1996VN15200003 ER PT J AU Englander, F Hodson, TJ Terregrossa, RA AF Englander, F Hodson, TJ Terregrossa, RA TI Economic dimensions of slip and fall injuries SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE forensic science; walkway safety; fall injuries; economic costs; cost-benefit analysis; government intervention ID OLDER ADULTS; RESIDENTS AB This paper provides an update of annual economic costs imposed by fall injuries. Such costs include medical, rehabilitation, hospital costs, and the costs of morbidity and mortality. These costs are projected to the year 2020, based on changing demographic trends. The market for slip and fall injury prevention is analyzed for the elderly and for those in the workplace-two high risk groups. Questions as to whether this market operates in a socially desirable manner, or whether government intervention is justified on efficiency grounds, are considered. Essential aspects of cost-benefit analysis are reviewed in the context of a prospective evaluation of interventions to prevent slip and fall injuries. The cost-benefit analysis framework is applied to part of the FICSIT experiment (a major intervention to reduce falls among the elderly) and to recent revisions in Occupational Safety and Health Administration regulations directed at reducing workplace falls. C1 USA,CORPS ENGINEERS,NEW YORK,NY. ST JOHNS UNIV,ECON & FINANCE DEPT,STATEN ISL,NY 10301. RP Englander, F (reprint author), FAIRLEIGH DICKINSON UNIV,ECON & FINANCE DEPT,285 MADISON AVE,MADISON,NJ 07940, USA. NR 42 TC 216 Z9 226 U1 11 U2 24 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD SEP PY 1996 VL 41 IS 5 BP 733 EP 746 PG 14 WC Medicine, Legal SC Legal Medicine GA VE526 UT WOS:A1996VE52600004 PM 8789837 ER PT J AU Houck, MM Ubelaker, D Owsley, D Craig, E Grant, W Fram, R Woltanski, T Sandness, K AF Houck, MM Ubelaker, D Owsley, D Craig, E Grant, W Fram, R Woltanski, T Sandness, K TI The role of forensic anthropology in the recovery and analysis of Branch Davidian compound victims: Assessing the accuracy of age estimations SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE forensic science; forensic anthropology; physical anthropology; age-at-death estimation; Branch Davidian; compound ID OS-PUBIS AB Age-at-death estimations of 44 individuals (27 adults, 17 children) from the Branch Davidian sample were compared with their actual ages. Estimations were evaluated for bias and accuracy for the actual age at death. Although the overall average estimates correlated well with the actual ages (r = 0.946), several individuals displayed high residual requiring further analysis and review. These individuals displayed age-related features that did not correspond with the expected morphology for individuals of their ages. Several age estimation techniques scored these individuals with all bias in the same direction. These examples should serve as cautionary reminders that biology does not always correlate with expected outcomes, particularly in such multifaceted traits such as age. C1 NATL MUSEUM NAT HIST,SMITHSONIAN INST,DEPT ANTHROPOL,WASHINGTON,DC 20560. MED EXAMINERS OFF,FRANKFORT,KY. USA,CENT IDENTIFICAT LAB,HICKAM AFB,HONOLULU,HI. TARRANT CTY MED EXAMINERS OFF,CRIMINALIST LAB,FT WORTH,TX. RP Houck, MM (reprint author), FBI LAB,HAIRS & FIBERS UNIT,RM 3931,10TH & PENN AVE NW,WASHINGTON,DC 20535, USA. NR 30 TC 9 Z9 9 U1 1 U2 4 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD SEP PY 1996 VL 41 IS 5 BP 796 EP 801 PG 6 WC Medicine, Legal SC Legal Medicine GA VE526 UT WOS:A1996VE52600013 PM 8789840 ER PT J AU Dibble, ED Killgore, KJ Dick, GO AF Dibble, ED Killgore, KJ Dick, GO TI Measurement of plant architecture in seven aquatic plants SO JOURNAL OF FRESHWATER ECOLOGY LA English DT Article ID FORAGING EFFICIENCY; STRUCTURAL COMPLEXITY; MYRIOPHYLLUM-SPICATUM; HABITAT; FISH; MACROPHYTE; BLUEGILLS; BIOMASS; PREY; LIGHT AB We quantified architectural characteristics of seven aquatic macrophytes by measuring spatial complexity and shading properties. The plants were: Egeria densa, Hydrilla verticillata, Myriophyllum spicatum Potamogeton nodosus, Potamogeton pectinatus, Vallisineria americana, and Zosterella dubia). Two replicates of each plant were cultured in aquaria in concrete raceways. Light transparency and vertical and horizontal interstices measurements were taken at three strata level in each plant species. Spatial complexity was calculated by adding the ratio between interstices frequency and size from both vertical and horizontal axes. Mean density and size of plant interstices differed significantly among plant species (x(2) = 123, df = 6, P < 0.01) and were greatest along horizontal axes. Plant complexity was lowest in M. spicatum and highest in P. pectinatus. Shading properties were significantly different among plants (x(2) = 40, df = 5, P < 0.01), and significant inter- and intra-plant strata differences were noted. C1 USA ENGINEERS,WATERWAYS EXPT STN,VICKSBURG,MS 39180. USA ENGINEERS,AQUAT ECOSYST RES FACIL,LEWISVILLE,TX 75056. NR 22 TC 33 Z9 35 U1 5 U2 17 PU OIKOS PUBL INC PI LA CROSSE PA PO BOX 2558, LA CROSSE, WI 54601 SN 0270-5060 J9 J FRESHWATER ECOL JI J. Freshw. Ecol. PD SEP PY 1996 VL 11 IS 3 BP 311 EP 318 DI 10.1080/02705060.1996.9664453 PG 8 WC Ecology; Limnology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA VM970 UT WOS:A1996VM97000007 ER PT J AU Sladicka, SJ Benfanti, P Raab, M Becton, J AF Sladicka, SJ Benfanti, P Raab, M Becton, J TI Dupuytren's contracture in the black population: A case report and review of the literature SO JOURNAL OF HAND SURGERY-AMERICAN VOLUME LA English DT Review AB A case report of a 34-year-old black man with Dupuytren's contracture of his left small finger and review of the literature of Dupuytren's disease in the black population is presented. A high incidence of trauma (54%) was associated with these cases. C1 DWIGHT D EISENHOWER ARMY MED CTR,DEPT ORTHOPAED SURG,FT GORDON,GA 30905. NR 18 TC 2 Z9 2 U1 0 U2 2 PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS PI NEW YORK PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011 SN 0363-5023 J9 J HAND SURG-AM JI J. Hand Surg.-Am. Vol. PD SEP PY 1996 VL 21A IS 5 BP 898 EP 899 PG 2 WC Orthopedics; Surgery SC Orthopedics; Surgery GA VK553 UT WOS:A1996VK55300028 ER PT J AU Donta, ST Peduzzi, P Cross, AS Sadoff, J Haakenson, C Cryz, SJ Kauffman, C Bradley, S Gafford, G Elliston, D Beam, TR John, JF Ribner, B Cantey, R Welsh, CH Ellison, RT Young, EJ Hamill, RJ Leaf, H Schein, RMH Mulligan, M Johnson, C Abrutyn, E Griffiss, JM Hamadeh, R Eliasson, AH McClain, JB Melcher, GP Kelly, JW Byrne, WR Wallace, M Amundson, D Gumpert, B Slagle, D AF Donta, ST Peduzzi, P Cross, AS Sadoff, J Haakenson, C Cryz, SJ Kauffman, C Bradley, S Gafford, G Elliston, D Beam, TR John, JF Ribner, B Cantey, R Welsh, CH Ellison, RT Young, EJ Hamill, RJ Leaf, H Schein, RMH Mulligan, M Johnson, C Abrutyn, E Griffiss, JM Hamadeh, R Eliasson, AH McClain, JB Melcher, GP Kelly, JW Byrne, WR Wallace, M Amundson, D Gumpert, B Slagle, D TI Immunoprophylaxis against Klebsiella and Pseudomonas aeruginosa infections SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID INTRAVENOUS IMMUNOGLOBULIN; IMMUNE GLOBULIN; RESISTANT; IMMUNOGENICITY; VACCINE; SAFETY; HUMANS; THERAPY; TOXIN AB To determine if passive immunization could decrease the incidence or severity of Klebsiella and Pseudomonas aeruginosa infections, patients admitted to intensive care units of 16 Department of Veterans Affairs and Department of Defense hospitals were randomized to receive either 100 mg/kg intravenous hyperimmune globulin (IVIG), derived from donors immunized with a 24-valent Klebsiella capsular polysaccharide plus an 8-valent P. aeruginosa O-polysaccharide-toxin A conjugate vaccine, or an albumin placebo. The overall incidence and severity of vaccine-specific Klebsiella plus Pseudomonas infections were not significantly different between the groups receiving albumin and IVIG. There was some evidence that IVIG may decrease the incidence (2.7% albumin vs. 1.2% IVIG) and severity (1.0% vs. 0.3%) of vaccine-specific Klebsiella infections, but these reductions were not statistically significant. The trial was stopped because it was statistically unlikely that IVIG would be protective against Pseudomonas infections at the dosage being used. Patients receiving IVIG had more adverse reactions (14.4% vs. 9.2%). C1 VET ADM MED CTR,ANN ARBOR,MI 48105. VET ADM MED CTR,ASHEVILLE,NC. VET ADM MED CTR,BUFFALO,NY 14215. VET ADM MED CTR,NEW YORK,NY 10010. VET ADM MED CTR,CHARLESTON,SC 29403. VET ADM MED CTR,DENVER,CO 80220. VET ADM MED CTR,HOUSTON,TX 77211. VET ADM MED CTR,MIAMI,FL 33125. VET ADM MED CTR,LONG BEACH,CA 90822. VET ADM MED CTR,SAN FRANCISCO,CA 94121. VET ADM MED CTR,PHILADELPHIA,PA 19104. VET ADM COOPERAT STUDIES COORDINATING CTR,WEST HAVEN,CT. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. VET COOPERAT STUDIES CENT RES PHARM,ALBUQUERQUE,NM. SWISS SERUM & VACCINE INST,CH-3001 BERN,SWITZERLAND. WILFORD HALL USAF MED CTR,LACKLAND AFB,TX 78236. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. WILLIAM BEAUMONT ARMY MED CTR,EL PASO,TX 79920. FITZSIMONS ARMY MED CTR,AURORA,CO 80045. USN HOSP,SAN DIEGO,CA 92134. RP Donta, ST (reprint author), VET ADM MED CTR,150 S HUNTINGTON AVE,BOSTON,MA 02130, USA. NR 24 TC 60 Z9 61 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD SEP PY 1996 VL 174 IS 3 BP 537 EP 543 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA VE493 UT WOS:A1996VE49300013 PM 8769611 ER PT J AU Dohm, DJ Logan, TM Linthicum, KJ Rossi, CA Turell, MJ AF Dohm, DJ Logan, TM Linthicum, KJ Rossi, CA Turell, MJ TI Transmission of Crimean-Congo hemorrhagic fever virus by Hyalomma impeltatum (Acari: Ixodidae) after experimental infection SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Hyalomma impeltatum; Crimean-Congo hemorrhagic fever virus; vector competency ID TRUNCATUM TICKS AB We examined the potential for Hyalomma impeltatum Schulze & Schlottke ticks to transmit Crimean-Congo hemorrhagic fever (CCHF) virus. Ater feeding on 1-d-old mice that had been inoculated with CCHF virus, larval H. impeltatum became infected with and subsequently transmitted CCHF virus transstadially to nymphs. These nymphs transmitted virus horizontally to guinea pigs and transstadially to adults. A minimum of 13% of the adult H. impeltatum, exposed to virus as larvae, transmitted virus by bite to guinea pigs. An enzyme-linked immunosorbent assay detected CCHF viral antigen in 63% of the adult ticks derived from those exposed to this virus as larvae. This tick species should be considered as a potential vector of CCHF virus. RP Dohm, DJ (reprint author), USA,MED RES INST INFECT DIS,DIAGNOST SYST DIV,FREDERICK,MD 21702, USA. NR 25 TC 14 Z9 16 U1 0 U2 1 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD SEP PY 1996 VL 33 IS 5 BP 848 EP 851 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA VE591 UT WOS:A1996VE59100020 PM 8840695 ER PT J AU Snyder, AP Blyth, DA Parsons, JA AF Snyder, AP Blyth, DA Parsons, JA TI Ion mobility spectrometry as an immunoassay detection technique SO JOURNAL OF MICROBIOLOGICAL METHODS LA English DT Article DE Bacillus cereus; bacterial detection; immunoassay; ion mobility spectrometry; ortho-nitrophenol ID ENVIRONMENTAL-ANALYSIS; IDENTIFICATION; ENUMERATION; BACTERIA; COLIFORMS; SYSTEM AB Conventional immunoassays employ a variety of techniques which usually have a spectrophotometric or fluorescence spectral method of detection to signal the presence of the targeted antigen in a suspect sample. As the concentration of the antigen is changed, a sigmoid-shape curve results from the response of the assay. A hand-held ion mobility spectrometer, which detects analyte ions at atmospheric pressure, was used to probe the ortho-nitrophenol (ONP) product vapor of an immunoassay reaction. Bacillus cereus organisms were employed in an enzyme-linked immunosorbent assay (ELISA) with the beta-galactosidase: ortho-nitrophenyl-beta-D-galactoside (ONPG) enzyme-substrate biochemical couple. ONP has an intense yellow color, and the ion mobility vapor responses were compared to that of the conventional spectrophotometric assay. Both detection techniques produced a sigmoid-shape curve characteristic of immunoassay experiments, and the bacterial detection limit with the ion mobility spectrometry technique was estimated at below 1000 cells for an 8 min assay time. Thus, a commercial, hand-held chemical vapor detector is shown to have the potential of detecting the presence of microorganisms using an immunoassay format. C1 GEOCENTERS INC,GUNPOWDER BRANCH,ABERDEEN PROVING GROUND,MD 21010. RP Snyder, AP (reprint author), USA,EDGEWOOD RES DEV & ENGN CTR,SCBRD,RTE,ABERDEEN PROVING GROUND,MD 21010, USA. NR 32 TC 12 Z9 12 U1 1 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-7012 J9 J MICROBIOL METH JI J. Microbiol. Methods PD SEP PY 1996 VL 27 IS 1 BP 81 EP 88 DI 10.1016/0167-7012(96)00931-1 PG 8 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA VW286 UT WOS:A1996VW28600010 ER PT J AU Mellen, PF Cooper, LI Skoog, SJ Edwards, EG Ho, CK AF Mellen, PF Cooper, LI Skoog, SJ Edwards, EG Ho, CK TI Bilateral metastatic renal cell carcinoma in a 3 year old child - Unusual clinical outcome SO JOURNAL OF NEUROLOGICAL AND ORTHOPAEDIC MEDICINE AND SURGERY LA English DT Article DE renal cell carcinoma; pediatrics ID WILMS-TUMOR AB Renal cell carcinoma (RCC) the most common solid renal tumor in adults, is infrequently present in childhood. Only 200 cases of RCC in children have been reported. Bilateral RCC in a very young child is exceeding rare. Likewise, survival with metastatic disease is nearly unprecedented. We report a case of metastatic bilateral RCC in a 3 year old child with stable, unresectable disease over 4 years of follow up. C1 WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT PEDIAT HEMATOL ONCOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT UROL SURG,WASHINGTON,DC 20307. NR 16 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD NEUROLOGICAL ORTHOPAEDIC SURGEONS PI LAS VEGAS PA 2300 SOUTH RANCHO DR, STE 202, LAS VEGAS, NV 89102 SN 0890-6599 J9 J NEUROL ORTH MED S JI J. Neurol. Orthop. Med. Surg. PD FAL PY 1996 VL 17 IS 2 BP 137 EP 139 PG 3 WC Neurosciences; Orthopedics SC Neurosciences & Neurology; Orthopedics GA WG089 UT WOS:A1996WG08900014 ER PT J AU Leitschuh, PH Doherty, TJ Taylor, DC Brooks, DE Ryan, JB AF Leitschuh, PH Doherty, TJ Taylor, DC Brooks, DE Ryan, JB TI Effects of postmortem freezing on tensile failure properties of rabbit extensor digitorum longus muscle tendon complex SO JOURNAL OF ORTHOPAEDIC RESEARCH LA English DT Article ID LIGAMENT AB The tensile failures of extensor digitorum longus muscle tendon units front 16 male Neu Zealand White rabbits were studied in the fresh state (less than 30 minutes after death) and in the frozen/thawed state (frozen at -80 degrees C for 28 days and then warmed to 38 degrees C). Frozen/thawed extensor digitorum longus muscle tendon units had significantly lower values for load to failure (p < 0.1), energy absorbed to failure (p < 0.01), and strain al failure (p < 0.01), and they tended to fail at a different anatomic location (p < 0.01) (broadly at the fascia-muscle interface as compared with horizontally at the musculotendinous junction) than fresh units, The results of this study suggest that freezing muscle tendon units significantly alters their tensile failure characteristics. C1 USA,INST SURG RES,FT SAM HOUSTON,TX 78234. KELLER ARMY HOSP,W POINT,NY. RP Leitschuh, PH (reprint author), WILLIAM BEAUMONT ARMY MED CTR,DEPT ORTHOPED,EL PASO,TX 79920, USA. NR 8 TC 17 Z9 18 U1 0 U2 2 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 SN 0736-0266 J9 J ORTHOPAED RES JI J. Orthop. Res. PD SEP PY 1996 VL 14 IS 5 BP 830 EP 833 DI 10.1002/jor.1100140522 PG 4 WC Orthopedics SC Orthopedics GA VP972 UT WOS:A1996VP97200021 PM 8893779 ER PT J AU Seltzer, MD Wright, AO Morrison, CA Wortman, DE Gruber, JB Filer, ED AF Seltzer, MD Wright, AO Morrison, CA Wortman, DE Gruber, JB Filer, ED TI Optical spectra, energy levels and branching ratios of trivalent dysprosium-doped yttrium scandium gallium garnet SO JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS LA English DT Article DE optical materials; crystal fields; optical properties ID INTENSITY CALCULATIONS; THULIUM IONS AB Absorption spectra of trivalent dysprosium ions in yttrium scandium gallium garnet are reported between 2.9 and 0.4 mu m at 4 K. Laser-excited fluorescence was observed at 4 K for transitions between the F-4(9/2) manifold and several of the lower-lying H-6(J) and F-6(J) manifolds. A crystal-field splitting calculation was carried out in which a parametrized Hamiltonian (including Coulombic, spin-orbit, and crystal field terms in D-2 symmetry) was diagonalized for selected manifolds of the Dy3+ (4f(9)) configuration. The RMS deviation between 69 experimental and calculated Stark levels was 8 cm(-1). Calculations were carried out to predict branching ratios for emission from the F-4(9/2) manifold. C1 USA,RES LAB,ADELPHI,MD 20783. SAN JOSE STATE UNIV,DEPT PHYS,SAN JOSE,CA 95192. NORFOLK STATE UNIV,CTR MAT RES,NORFOLK,VA 23504. RP Seltzer, MD (reprint author), USN,WARFARE CTR,WEAPONS DIV,CHINA LAKE,CA 93555, USA. NR 20 TC 20 Z9 20 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0022-3697 J9 J PHYS CHEM SOLIDS JI J. Phys. Chem. Solids PD SEP PY 1996 VL 57 IS 9 BP 1175 EP 1182 DI 10.1016/0022-3697(95)00248-0 PG 8 WC Chemistry, Multidisciplinary; Physics, Condensed Matter SC Chemistry; Physics GA VC879 UT WOS:A1996VC87900001 ER PT J AU Wright, AO Seltzer, MD Gruber, JB Zandi, B Merkle, LD Chai, BHT AF Wright, AO Seltzer, MD Gruber, JB Zandi, B Merkle, LD Chai, BHT TI Spectroscopic investigation of Pr3+ fluorapatite crystals SO JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS LA English DT Article DE inorganic compounds; luminescence; crystal fields; optical properties ID SITE-SELECTIVE SPECTROSCOPY; ENERGY-LEVELS; FIELD ANALYSIS; LASER; SPECTRA; IONS; FLUOROPHOSPHATE; LUMINESCENCE; ABSORPTION; APATITES AB Spectroscopic data is presented for Pr3+-doped calcium fluorapatite (Ca-5(PO4)(3)F) and strontium fluorapatite (Sr-5(PO4)(3)F) crystals which were studied using polarized absorption and laser-induced fluorescence as optical probes. Complete tabulation of experimental energy levels is provided for strontium fluorapatite, where only one Pr3+ site, having C-s symmetry, is measurable. In calcium fluorapatite, at least three Pr3+ sites of appreciable concentration are evident, though the majority site is demonstrated to show similarity to the site in the strontium fluorapatite host. An unusually high crystal field splitting of Pr3+ energy levels is exhibited in both hosts. Intersite energy transfer, upconversion and cross relaxation are discussed for Pr3+ in the calcium fluorapatite crystal. C1 NAVAL AIR WARFARE CTR,RES & TECHNOL DIV,CHINA LAKE,CA 93555. SAN JOSE STATE UNIV,DEPT PHYS,SAN JOSE,CA 95192. USA,RES LAB,IR OPT TECHNOL OFC,FT BELVOIR,VA 22060. UNIV CENT FLORIDA,CTR RES ELECTROOPT & LASERS,ORLANDO,FL 32836. NR 31 TC 18 Z9 18 U1 2 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0022-3697 J9 J PHYS CHEM SOLIDS JI J. Phys. Chem. Solids PD SEP PY 1996 VL 57 IS 9 BP 1337 EP 1350 DI 10.1016/0022-3697(95)00418-1 PG 14 WC Chemistry, Multidisciplinary; Physics, Condensed Matter SC Chemistry; Physics GA VC879 UT WOS:A1996VC87900022 ER PT J AU Mikhail, AG AF Mikhail, AG TI In-flight flexure and spin lock-in for antitank kinetic energy projectiles SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article AB A time-dependent analysis, coupling the rod vibration equation and pure roll motion equation, is formulated to numerically simulate the in-flight bending behavior of antitank kinetic energy projectile rods. The projectile is modeled as undergoing continuous, simulated planar pitching motion with the aerodynamic, spin, and structural damping forces included. The main parameter affecting the projectile spin and rod deflection responses is the fin torque producing the spin. Detailed spin, deflection, maximum stress, pitching angle, and rod shape histories are obtained along the projectile trajectory. Various steady-state spin cases are studied to simulate the effect of damaged fins. The spin lock-in phenomenon at the first lateral flexing natural frequency is captured by the present model for rods with simulated damaged fins. Any deformable projectile attempting, because of damaged fins, to spin past that frequency was found to lock-in to spinning at that frequency. Both sub- and supercritical spin cases are computed. Predictions of the rod shape at any instant and under actual Right conditions are made. RP Mikhail, AG (reprint author), USA,RES LAB,DIV PROPULS & FLIGHT,WEAPONS TECHNOL DIRECTORATE,ABERDEEN PROVING GROUND,MD 21005, USA. NR 15 TC 7 Z9 7 U1 0 U2 2 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0022-4650 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD SEP-OCT PY 1996 VL 33 IS 5 BP 657 EP 664 DI 10.2514/3.26817 PG 8 WC Engineering, Aerospace SC Engineering GA VM676 UT WOS:A1996VM67600010 ER PT J AU Cochran, ES AF Cochran, ES TI Deliberate ambiguity: An analysis of Israel's nuclear strategy SO JOURNAL OF STRATEGIC STUDIES LA English DT Article RP Cochran, ES (reprint author), USA,WASHINGTON,DC 20310, USA. NR 38 TC 1 Z9 1 U1 0 U2 0 PU FRANK CASS CO LTD PI ESSEX PA NEWBURY HOUSE, 900 EASTERN AVE, NEWBURY PARK, ILFORD, ESSEX, ENGLAND IG2 7HH SN 0140-2390 J9 J STRATEGIC STUD JI J. Strateg. Stud. PD SEP PY 1996 VL 19 IS 3 BP 321 EP 342 DI 10.1080/01402399608437642 PG 22 WC International Relations; Political Science SC International Relations; Government & Law GA WB488 UT WOS:A1996WB48800002 ER PT J AU Leek, MR Summers, V AF Leek, MR Summers, V TI Reduced frequency selectivity and the preservation of spectral contrast in noise SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article; Proceedings Paper CT 3rd Joint Meeting of the Acoustical-Society-of-America/Acoustical-Society-of-Japan CY DEC 02-06, 1996 CL HONOLULU, HI SP Acoust Soc Amer, Acoust Soc Japan ID HEARING-IMPAIRED LISTENERS; AUDITORY FILTER SHAPES; SPEECH-PERCEPTION; IDENTIFICATION; DISCRIMINATION; SENTENCES; THRESHOLD; RECEPTION; LEVEL; AGE AB Reduced frequency selectivity associated with sensorineural hearing loss may pose particular problems for hearing-impaired listeners in noisy environments. In these situations, broader-than-normal auditory filters may affect the perception of speech by reducing the contrast between spectral peaks and valleys in at least two ways. First, the peaks and valleys in the internal representation of the speech spectrum become smeared, resulting in less precise frequency analysis. Second, there may be a reduction in the signal-to-noise ratio (S/N) at the output of each auditory filter. In order to examine the relationship between frequency selectivity and identification of speechlike stimuli in noise, hearing-impaired and normal-hearing listeners were trained to assign vowel labels to four harmonic complexes which differed in the frequency locations of four elevated (''peak'') harmonics. Peak harmonics were chosen to approximate first- and second-formant frequencies in four English vowels. Listeners were then tested to determine the spectral contrast necessary between peak and background components in order to maintain identification accuracy in the presence of various levels of broadband noise. Results indicated that for these stimuli, normal-hearing listeners required about 1 dB of additional spectral contrast for every doubling of the intensity of noise. The required increase in spectral contrast was generally greater for listeners with broader-than-normal auditory filters at 2000 Hz. This finding suggests indirectly that in the internal representations of speech sounds embedded in noise, the signal-to-noise ratio for listeners with abnormal frequency selectivity is poorer than for listeners with normal frequency selectivity. A poorer-than-normal internal S/N may be one factor underlying the common observation that noise often is more degrading to speech understanding by hearing-impaired listeners than by normal-hearing listeners. RP Leek, MR (reprint author), WALTER REED ARMY MED CTR,ARMY AUDIOL & SPEECH CTR,WASHINGTON,DC 20307, USA. FU NIDCD NIH HHS [DC 00626] NR 24 TC 32 Z9 32 U1 1 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD SEP PY 1996 VL 100 IS 3 BP 1796 EP 1806 DI 10.1121/1.415999 PG 11 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA VK273 UT WOS:A1996VK27300062 PM 8817905 ER PT J AU Smith, KJ Vidmar, D Skelton, HG Hackley, BE AF Smith, KJ Vidmar, D Skelton, HG Hackley, BE TI Improved results of delayed-type hypersensitivity skin testing in HIV-infected patients treated with topical dinitrochlorobenzene SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Letter ID IMMUNODEFICIENCY-VIRUS INFECTION; T-CELL LYMPHOMA; DNCB C1 NATL NAVAL MED CTR, DERMATOL SERV, BETHESDA, MD USA. ARMED FORCES INST PATHOL, WASHINGTON, DC 20306 USA. RP Smith, KJ (reprint author), USA, MED RES INST CHEM DEF, ABERDEEN, MD USA. NR 18 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD SEP PY 1996 VL 35 IS 3 BP 491 EP 492 DI 10.1016/S0190-9622(96)90642-8 PN 1 PG 2 WC Dermatology SC Dermatology GA VF215 UT WOS:A1996VF21500031 PM 8784300 ER PT J AU BarOn, I Baratta, FI Cho, K AF BarOn, I Baratta, FI Cho, K TI Crack stability and its effect on fracture toughness of hot-pressed silicon nitride beam specimens SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID CERAMIC MATERIALS; INDENTATION AB The effect of stable crack extension on fracture toughness test results was determined using single-edge precracked beam specimens, Crack growth stability was examined theoretically for bars loaded in three-point bending under displacement control, The calculations took into account the stiffness of both the specimen and the loading system, The results indicated that the stiffness of the testing system played a major role in crack growth stability, Accordingly, a test system and specimen dimensions were selected which would result in unstable or stable crack extension during the fracture toughness test, depending on the exact test conditions, Hot-pressed silicon nitride bend bars (NC132) were prepared with precracks of different lengths, resulting in specimens with different stiffnesses. The specimens with the shorter precracks and thus higher stiffness broke without stable crack extension, while those with longer cracks, and lower stiffness, broke after some stable crack extension, The fracture toughness values from the unstable tests were 10% higher than those from the stable tests, This difference, albeit small, is systematic and is not considered to be due to material or specimen-to-specimen variation. It is concluded that instability due to the stiffness of test system and specimen must be minimized to ensure some stable crack extension in a fracture toughness test of brittle materials in order to avoid inflated fracture toughness values. C1 USA,RES LAB,WATERTOWN,MA 02172. RP BarOn, I (reprint author), WORCESTER POLYTECH INST,DEPT MECH ENGN,WORCESTER,MA 01609, USA. NR 32 TC 25 Z9 25 U1 0 U2 2 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, PO BOX 6136, WESTERVILLE, OH 43081-6136 SN 0002-7820 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD SEP PY 1996 VL 79 IS 9 BP 2300 EP 2308 DI 10.1111/j.1151-2916.1996.tb08976.x PG 9 WC Materials Science, Ceramics SC Materials Science GA VJ727 UT WOS:A1996VJ72700010 ER PT J AU Sithiprasasna, R Luepromchai, E Linthicum, KJ AF Sithiprasasna, R Luepromchai, E Linthicum, KJ TI Effects of sublethal dosages of methoprene on Anopheles dirus species A and B SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article ID CULEX-QUINQUEFASCIATUS; AEDES AB Anopheles dirus species A and B individuals were exposed as 4th-stage larvae to sublethal concentrations of methoprene. Median lethal concentrations were 0.21 ppb for species A and 0.17 ppb for species B. When exposed to 0.10 ppb methoprene the sex ratio of species A changed from fewer males to more males; no effect was observed in the sex ratio of species B. Exposure to methoprene had no effect on wing length and survival of either species. Results indicate that exposure to methoprene significantly affected fecundity of both species of An. dirus. RP Sithiprasasna, R (reprint author), ARMED FORCES RES INST MED SCI,USA MED COMPONENT,DEPT ENTOMOL,315-6 RAJVISHI RD,BANGKOK 10400,THAILAND. NR 14 TC 8 Z9 9 U1 1 U2 3 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD SEP PY 1996 VL 12 IS 3 BP 483 EP 486 PN 1 PG 4 WC Entomology SC Entomology GA VJ447 UT WOS:A1996VJ44700040 PM 8887229 ER PT J AU Salzberg, DJ Carome, MA Yuan, CM AF Salzberg, DJ Carome, MA Yuan, CM TI Lazaroids block the protective effect of heat shock in LLC-PK1 cells. SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Meeting Abstract C1 SERV NEPHROL,WASHINGTON,DC. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD SEP PY 1996 VL 7 IS 9 BP A2993 EP A2993 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA VK074 UT WOS:A1996VK07402987 ER PT J AU Staley, D Carome, M Yuan, C AF Staley, D Carome, M Yuan, C TI Effect of calcium on Hsp70 gene expression after heat shock or cyclosporine exposure in LLC-PK1 cells. SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Meeting Abstract C1 SERV NEPHROL,WASHINGTON,DC. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD SEP PY 1996 VL 7 IS 9 BP A3000 EP A3000 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA VK074 UT WOS:A1996VK07402994 ER PT J AU Matylevich, NP Chu, CS McManus, AT Mason, AD Pruitt, BA AF Matylevich, NP Chu, CS McManus, AT Mason, AD Pruitt, BA TI Direct current reduces plasma protein extravasation after partial-thickness burn injury in rats SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE partial-thickness burn; protein extravasation; silver-nylon; electric current ID DIFFUSION; MESENTERY; FIELDS; EDEMA AB Objective: To observe the effect of 40 mu A direct current (DC) on plasma albu Design, Materials, and Methods: Silver-nylon wound dressings were used as anodes (-) an anesthetized male Sprague-Dawley rats with 20% total body surface partial-thickness scald burns, Burned rats with no treatment, or treated with siver-nylon dressing without current, were used as controls, Quantitative analysis of fluorescein isothiocyanate (FITC)-albumin leakage and accumulation in the wound tissue was performed using confocal fluorescence microscopy. Measurements and Main Results: In controls, the rate of albumin leakage was maximal at 1 hour postburn (PB) and then decreased, but remained higher than normal for 48 hours PB. The accumulation of FITC-albumin was maximal 4 to 6 hours PB and substantial for 48 hours, When DC was applied, leakage was reduced by 30 to 45% and approached normal control rates bg 8 hours PB. FITC-albumin concentration peaked 4 hours PB, mas 18 to 48% less then in burned control, and approached the level observed in unburned control by 18 hours PB. Conclusions: DC has a beneficial effect in reducing plasma protein extravasation after burn injury. RP USA, INST SURG RES, LIB BRANCH, 3400 RAWLEY E CHAMBERS AVE, FT SAM HOUSTON, TX 78234 USA. NR 39 TC 6 Z9 7 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0022-5282 EI 1529-8809 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD SEP PY 1996 VL 41 IS 3 BP 424 EP 429 DI 10.1097/00005373-199609000-00007 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA VH571 UT WOS:A1996VH57100010 PM 8810958 ER PT J AU Bettencourt, MC Bauer, JJ Sesterhenn, IA Mostofi, FK McLeod, DG Moul, JW AF Bettencourt, MC Bauer, JJ Sesterhenn, IA Mostofi, FK McLeod, DG Moul, JW TI Ki-67 expression is a prognostic marker of prostate cancer recurrence after radical prostatectomy SO JOURNAL OF UROLOGY LA English DT Article DE prostatic neoplasms; tumor markers, biological; neoplasm metastasis; prostatectomy ID MONOCLONAL-ANTIBODY KI-67; DEFINED GROWTH FRACTION; PROLIFERATIVE ACTIVITY; ANTIGEN; CARCINOMA; ADENOCARCINOMA; TIME; MEN; STATISTICS; THERAPY AB Purpose: We assessed the cellular proliferation of clinically localized prostate cancer by immunohistochemistry using the monoclonal antibody MIB to Ki-67 antigen in an attempt to identify associations between proliferative indexes and disease progression following radical prostatectomy. Materials and Methods: Ki-67 proliferative antigen was evaluated using MIB 1 monoclonal antibody in archival paraffin embedded radical prostatectomy specimens from 180 patients followed for 1 to 9 years (mean 4.4). The percentage of tumor nuclei expressing Ki-67 antigen was measured and assigned an MIB 1 score (none or rare-negative, 1+-low score and 2 to 4+-high score) and analyzed for prostate specific antigen, stage, age, race, grade and serological recurrence postoperatively. Results: There was a significant association between MIB 1 score and nuclear grade (p <0.001), Gleason score (p <0.001) and pathological stage (p = 0.01). Patients with a high MIB 1 score had earlier progression and a lower 5-year recurrence-free survival rate (44%) than those with negative MIB 1 scores (71%, p <0.001). In multivariate Cox regression analysis with backward elimination, pathological stage (p <0.01), pretreatment prostate specific antigen (p = 0.04) and MIB 1 score (p = 0.05) were statistically significant predictors of disease-free survival, and patients with a high MIB 1 score were 3.1 times as likely to have recurrence as those with a negative score. Controlling for stage, patients with organ confined disease and a high MIB 1 score had a lower 5-year disease-free survival rate (68%) than those with a low MIB 1 score (95%, p <0.01). Conclusions: Proliferative activity as measured by the Ki-67 proliferative antigen, MIB 1, appears to be a prognostic marker of recurrent prostate cancer after radical prostatectomy. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,CTR PROSTATE DIS RES,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,DEPT GENITOURINARY PATHOL,WASHINGTON,DC 20306. NR 30 TC 117 Z9 118 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD SEP PY 1996 VL 156 IS 3 BP 1064 EP 1068 DI 10.1016/S0022-5347(01)65703-3 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA VB453 UT WOS:A1996VB45300061 PM 8709308 ER PT J AU Carr, JK Salminen, MO Koch, C Gotte, D Artenstein, AW Hegerich, PA StLouis, D Burke, DS McCutchan, FE AF Carr, JK Salminen, MO Koch, C Gotte, D Artenstein, AW Hegerich, PA StLouis, D Burke, DS McCutchan, FE TI Full-length sequence and mosaic structure of a human immunodeficiency virus type 1 isolate from Thailand SO JOURNAL OF VIROLOGY LA English DT Article ID INJECTING DRUG-USERS; HIV-1 TAT PROTEIN; MOLECULAR CHARACTERIZATION; SUBTYPE-E; RNA; RECOMBINATION; BINDING; TRANSACTIVATION; TRANSCRIPTION; PSEUDOTYPES AB Human immunodeficiency virus type 1 isolates of envelope genotype E are contributing substantially to the global pandemic, These strains appear to be mosaics, with the gag gene from clade A and the envelope from clade E; the parental clade E strain has not been found, Here we report the first full genomic sequence of one such mosaic virus, isolate CM240 from Thailand, Multiple breakpoints between the two parental genotypes have been found in a CM240 virus, The entire gag-pol region and most, if not all, of the accessory genes vif, vpr, tat, rev, and vpu appear to derive from clade A. The genotype switches to E shortly after the signal peptide of the envelope and back to clade A near the middle of gp41; thus, the portion of the envelope that lies on the cytoplasmic side of the membrane appears to be principally derived not from clade E, as previously thought, but from clade A, Another small segment not belonging to any recognized clade and presumably also contributed by the parental E strain has been found in the long terminal repeat, It may be significant that the implied virion structure resembles a pseudotype virus with the matrix and core from one clade and the outer envelope from another. In the long terminal repeat, differences were observed between CM240 and other clades in the number of NF-kappa B binding sites, the sequence of the TATA box, and the putative secondary structure of the transactivation response region stem-loop. The mosaic structure of a CM240 virion is suggestive of phenotypic differences which might have contributed to the emergence of this variant. C1 HENRY M JACKSON FDN ADVANCEMENT MIL MED,ROCKVILLE,MD 20850. WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD 20850. RI Salminen, Mika/D-8784-2013; OI Salminen, Mika/0000-0003-3020-0866; /0000-0002-5704-8094 NR 57 TC 195 Z9 203 U1 2 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD SEP PY 1996 VL 70 IS 9 BP 5935 EP 5943 PG 9 WC Virology SC Virology GA VB415 UT WOS:A1996VB41500027 PM 8709215 ER PT J AU Thompson, EF Chen, HS Hadley, LL AF Thompson, EF Chen, HS Hadley, LL TI Validation of numerical model for wind waves and swell in harbors SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article ID BOUSSINESQ EQUATIONS; FORM AB The numerical wave model HARED has been used extensively within and outside the U.S. Army Corps of Engineers for estimating waves in harbors. The model was originally developed for long waves (harbor oscillations). It has been extended for use with short waves (wind waves and swell) and validated by several investigations, most notably Chen's (1986) fundamental investigation of long waves in a rectangular harbor. This study focuses on short-wave validation. The model is tested with several simple domains, in most cases with uniform depth. It is validated with laboratory data for irregular wave diffraction around a semi-infinite breakwater. Both broad and narrow directional spreads are considered. The model is also compared to widely accepted curves for regular and irregular wave diffraction through a breakwater gap. Field validation of the model for Kaumalapau Harbor, Lanai, Hawaii, is discussed. Tests demonstrate the effect of input parameters on model results and provide guidelines about the choice of parameter values in future modeling efforts. C1 DOC,NOAA,NWS,NCEP,CAMP SPRINGS,MD 20746. RP Thompson, EF (reprint author), USA,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 34 TC 14 Z9 14 U1 1 U2 2 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD SEP-OCT PY 1996 VL 122 IS 5 BP 245 EP 257 DI 10.1061/(ASCE)0733-950X(1996)122:5(245) PG 13 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA VD976 UT WOS:A1996VD97600006 ER PT J AU Barth, J AF Barth, J TI Gifting to people you love: The complete parents' and grandparents' guide to gifting and investing for children - Berg,AG SO LIBRARY JOURNAL LA English DT Book Review RP Barth, J (reprint author), US MIL ACAD LIB,W POINT,NY, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD SEP 1 PY 1996 VL 121 IS 14 BP 189 EP 189 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA VF870 UT WOS:A1996VF87000108 ER PT J AU McCarthy, MJ Peake, MF Lillis, P Vukelja, SJ AF McCarthy, MJ Peake, MF Lillis, P Vukelja, SJ TI Paclitaxel-induced radiation recall dermatitis SO MEDICAL AND PEDIATRIC ONCOLOGY LA English DT Article DE paclitaxel; docetaxel; taxane; radiation; dermatitis ID TAXOL; PNEUMONITIS; ADRIAMYCIN; CANCER AB The authors present a case oi radiation recall dermatitis occurring in a patient receiving paclitaxel shortly after completion of radiation therapy. A brief review oi previously reported taxane-induced radiation recall reactions is provided. (C) 1996 Wiley-Liss, Inc. C1 BROOKE ARMY MED CTR,DERMATOL SERV,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,HEMATOL ONCOL SERV,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DEPT MED,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,RADIAT THERAPY SERV,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DEPT RADIOL,FT SAM HOUSTON,TX 78234. RP McCarthy, MJ (reprint author), WOMACK ARMY MED CTR,HEMATOL ONCOL SERV,DEPT MED,FT BRAGG,NC 28307, USA. NR 15 TC 25 Z9 26 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0098-1532 J9 MED PEDIATR ONCOL JI Med. Pediatr. Oncol. PD SEP PY 1996 VL 27 IS 3 BP 185 EP 186 DI 10.1002/(SICI)1096-911X(199609)27:3<185::AID-MPO9>3.0.CO;2-A PG 2 WC Oncology; Pediatrics SC Oncology; Pediatrics GA VA647 UT WOS:A1996VA64700011 PM 8699997 ER PT J AU Sjogren, MH AF Sjogren, MH TI Serologic diagnosis of viral hepatitis SO MEDICAL CLINICS OF NORTH AMERICA LA English DT Review ID NON-B-HEPATITIS; POLYMERASE CHAIN-REACTION; ANTIGEN-ANTIBODY SYSTEM; CHRONIC LIVER-DISEASE; NON-A-HEPATITIS; C VIRUS; IGM ANTIBODY; SURFACE-ANTIGEN; CLINICAL-SIGNIFICANCE; DELTA-HEPATITIS AB Viral hepatitis has become a difficult field in which clinical and laboratory skills are needed to establish the correct diagnosis and plan for the appropriate therapy. For example, it is no longer enough to diagnose chronic hepatitis B or C. Now, the viral titer or viral genotype must be known. The laboratory test then must be understood in the context of the clinical presentation. This article helps the clinician to acquire such working knowledge. It summarizes available data for hepatitis A, B, C, D, and E. It also includes the recently discovered viral agents, hepatitis G and the hepatitis GB agents. C1 GEORGETOWN UNIV, DEPT MED, WASHINGTON, DC USA. UNIFORMED SERV UNIV HLTH SCI, DEPT MED, WASHINGTON, DC USA. RP Sjogren, MH (reprint author), WALTER REED ARMY MED CTR, DEPT CLIN INVEST, WASHINGTON, DC 20307 USA. NR 108 TC 4 Z9 5 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0025-7125 J9 MED CLIN N AM JI Med. Clin. N. Am. PD SEP PY 1996 VL 80 IS 5 BP 929 EP + PG 0 WC Medicine, General & Internal SC General & Internal Medicine GA VF987 UT WOS:A1996VF98700004 PM 8804369 ER PT J AU Raugh, HE AF Raugh, HE TI Desert battle: Comparative perspectives - Watson,BA SO MIDDLE EAST JOURNAL LA English DT Book Review RP Raugh, HE (reprint author), USA,WASHINGTON,DC 20310, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU MIDDLE EAST INSTITUTE PI WASHINGTON PA 1761 N STREET NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 SN 0026-3141 J9 MIDDLE EAST J JI Middle East J. PD FAL PY 1996 VL 50 IS 4 BP 613 EP 614 PG 2 WC Area Studies SC Area Studies GA VP953 UT WOS:A1996VP95300021 ER PT J AU Shuman, CR AF Shuman, CR TI Managed psychiatric care: A suburban medical department activity model SO MILITARY MEDICINE LA English DT Article AB Munson Army Community Hospital has successfully realized substantial cost savings by instituting psychiatric managed care. The development of an external partnership with a civilian psychiatric facility is a unique aspect of the psychiatric managed care initiative and has resulted in most of the savings. We staff this partnership hospital with one-half full-time-equivalent psychiatrist, Other psychiatric managed care program elements include: (1) using CHAMPUS ''recapture'' funds to hire additional personnel; (2) maximizing personnel utilization by combining mental health staff from the social work and psychiatry services; (3) working closely with the community to identify local mental health needs; (4) offering additional therapeutic modalities; and (5) reducing rehospitalization rates through improved discharge planning, We reduced our financial-year first quarter costs by 76% from 1993 to 1995. We attributed much of these savings to reduced residential treatment admissions. Although the total number of outpatient visits increased, Munson's psychiatric services reduced outpatient costs by increasing clinic access. We have used the Gateway to Care program to prepare for the initiation of Tri-Care in our region. RP Shuman, CR (reprint author), USA,MED DEPT ACTIV,DEPT COMMUNITY MENTAL HLTH,550 POPE AVE,FT LEAVENWORTH,KS 66027, USA. NR 5 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 1996 VL 161 IS 9 BP 557 EP 561 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA VF858 UT WOS:A1996VF85800012 PM 8840798 ER PT J AU Randall, T Vance, AM Butler, N AF Randall, T Vance, AM Butler, N TI Rehabilitation of ten soldiers with exertional rhabdomyolysis SO MILITARY MEDICINE LA English DT Article AB This case study describes the rehabilitation of 10 active duty U.S. soldiers with exertional rhabdomyolysis, The pathophysiology of rhabdomyolysis is discussed, The initial management is concerned with accurate diagnosis and monitoring of laboratory values to prevent complications, Active and passive range of motion, strength, and induration were used as indicators of recovery, The goal of rehabilitation was to safely return patients to their basic training units without activity restrictions as quickly as possible, All 10 soldiers were able to pass the Army Physical Fitness Test at the end of their training cycle, For those patients with rhabdomyolysis who desire to return to a high level of function, close monitoring of exercise intensity appears to allow for a safe, expedient return to previous levels of function, This description of a rare disorder will increase awareness and stimulate discussion so that more specific guidelines for rehabilitation can be developed. RP Randall, T (reprint author), REYNOLDS ARMY COMMUNITY HOSP,PHYS THERAPY DEPT,FT SILL,OK 73503, USA. NR 12 TC 10 Z9 12 U1 0 U2 3 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 1996 VL 161 IS 9 BP 564 EP 566 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA VF858 UT WOS:A1996VF85800014 PM 8840800 ER PT J AU Riddle, WA AF Riddle, WA TI Southern conservative universalism SO MISSISSIPPI QUARTERLY LA English DT Article RP Riddle, WA (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU MISSISSIPPI QUARTERLY PI MISSISSIPPI STATE PA PO BOX 5272, MISSISSIPPI STATE, MS 39762 SN 0026-637X J9 MISS QUART JI Mississippi Q. PD FAL PY 1996 VL 49 IS 4 BP 819 EP 828 PG 10 WC Literary Theory & Criticism SC Literature GA WQ995 UT WOS:A1996WQ99500010 ER PT J AU Groza, JR Dowding, RJ AF Groza, JR Dowding, RJ TI Nanoparticulate materials densification SO NANOSTRUCTURED MATERIALS LA English DT Article ID STABILIZED TETRAGONAL ZIRCONIA; NANOCRYSTALLINE METALS; GRAIN-SIZE; NANOSTRUCTURED ZIRCONIA; MECHANICAL-BEHAVIOR; ULTRAFINE POWDERS; ATOMIC-STRUCTURE; APPLIED STRESS; COMPACTION; ENERGY AB The successful application of nanomaterials, with their unique mechanical, optical, magnetic and electrical properties, largely depends on the consolidation of powders into engineering components that will preserve an initial metastable microstructure. The key characteristic of the nanopowder consolidation process is to achieve densification without microstructural coarsening. This paper addresses specific densification issues related to the nanocrystalline nature of the consolidating particulates. The theoretical issues that affect the thermodynamics and kinetics of the atomic processes involved in nanopowder densification are related to higher driving force, enhanced interfacial energy and diffusion, and full density values. The experimental aspects cover powder compressibility and differential shrinkage, heating rate and pressure effects, and grain growth. Meaningful results in terms of final density values and grain growth are presented with the emphasis on processes that have demonstrated the capability to form dense specimens with retention of fine grain sizes. C1 USA,RES LAB,MAT DIRECTORATE,ABERDEEN PROVING GROUND,MD 21005. RP Groza, JR (reprint author), UNIV CALIF DAVIS,DEPT CHEM ENGN & MAT SCI,DAVIS,CA 95616, USA. RI Dowding, Robert/F-1469-2015 OI Dowding, Robert/0000-0002-4763-2131 NR 74 TC 124 Z9 130 U1 0 U2 17 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0965-9773 J9 NANOSTRUCT MATER JI Nanostruct. Mater. PD SEP-OCT PY 1996 VL 7 IS 7 BP 749 EP 768 DI 10.1016/S0965-9773(96)00046-3 PG 20 WC Materials Science, Multidisciplinary SC Materials Science GA VH673 UT WOS:A1996VH67300006 ER PT J AU Zimmerman, RL Ila, D Hirvonen, JK AF Zimmerman, RL Ila, D Hirvonen, JK TI Optimized system for hydrogen detection SO NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS LA English DT Article; Proceedings Paper CT 12th International Conference on Ion Beam Analysis (IBA-12) CY MAY 22-26, 1995 CL ARIZONA STATE UNIV CAMPUS, TEMPE, AZ HO ARIZONA STATE UNIV CAMPUS ID NUCLEAR-REACTION AB We have designed a coincidence array consisting of a BGO scintillator surrounded by an annular NaI scintillator specifically for detection of the 4.44 MeV gamma rays from the excited state of C-12 following the H-1(N-15, alpha gamma)C-12 resonant nuclear reaction used for hydrogen detection in solids. The limits for detection of hydrogen depend on the detector efficiency and background. Background is reduced because a count is accepted only when the NaI detects a 0.511 MeV annihilation gamma ray in coincidence with the detection by the BGO scintillator of the primary gamma ray energy less than the energy of an annihilation gamma ray; that is, 3.93 MeV. Assuming a signal to background ratio of 1, we report a detection limit of 7100 ppma per nA of N-15(3+) ion current with no external shielding. C1 ALABAMA A&M UNIV,CTR IRRADIAT MAT,NORMAL,AL 35762. USA,RES LAB,WATERTOWN,MA 02172. NR 4 TC 4 Z9 4 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-583X J9 NUCL INSTRUM METH B JI Nucl. Instrum. Methods Phys. Res. Sect. B-Beam Interact. Mater. Atoms PD SEP PY 1996 VL 118 IS 1-4 BP 206 EP 208 DI 10.1016/0168-583X(95)01455-1 PG 3 WC Instruments & Instrumentation; Nuclear Science & Technology; Physics, Atomic, Molecular & Chemical; Physics, Nuclear SC Instruments & Instrumentation; Nuclear Science & Technology; Physics GA VN261 UT WOS:A1996VN26100040 ER PT J AU Lu, MZ Yin, SH Chen, CL Yu, FTS Hudson, TD McMillen, DK AF Lu, MZ Yin, SH Chen, CL Yu, FTS Hudson, TD McMillen, DK TI Optimum synthesis of a bipolar composite reference function with a simulated annealing algorithm SO OPTICAL ENGINEERING LA English DT Article DE bipolar composite reference function; annealing algorithm; filters ID LIQUID-CRYSTAL TELEVISION; SPATIAL LIGHT-MODULATOR; PHASE MODULATION; BINARY PHASE; FILTERS; SIGNAL; OPTIMIZATION; KINOFORM; NOISE AB An optimum training process using a simulated annealing algorithm for synthesizing a spatial domain bipolar composite reference function (BCRF) is presented. The major advantages of the proposed BCRF filter are out-of-plane rotation invariance, higher discriminability (in particular, for similar targets), and convenience for optical implementation of a BCRF filter using a photorefractive (PR) crystal in a VanderLugt correlator is provided, in which we show that the experimental results agree with the simulation. (C) 1996 Society of Photo-Optical Instrumentation Engineers. C1 USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898. RP Lu, MZ (reprint author), PENN STATE UNIV,DEPT ELECT ENGN,UNIVERSITY PK,PA 16802, USA. NR 27 TC 10 Z9 12 U1 0 U2 1 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD SEP PY 1996 VL 35 IS 9 BP 2710 EP 2720 DI 10.1117/1.600836 PG 11 WC Optics SC Optics GA VG764 UT WOS:A1996VG76400036 ER PT J AU Manganaro, AM Startzell, JM AF Manganaro, AM Startzell, JM TI An asymptomatic enlargement of the upper lip SO ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS LA English DT Letter ID MYCOSIS-FUNGOIDES C1 USA,DENT CORPS,DEPT ORAL & MAXILLOFACIAL SURG,WASHINGTON,DC. USA,DENT CORPS,DEPT ANAT PATHOL,WASHINGTON,DC. USA,DENT CORPS,ORAL & MAXILLOFACIAL SURG CLIN,WASHINGTON,DC. USA,DENT CORPS,ORAL & MAXILLOFACIAL SURG RESIDENCY TRAINING PROG,WASHINGTON,DC. NR 5 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 1079-2104 J9 ORAL SURG ORAL MED O JI Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. PD SEP PY 1996 VL 82 IS 3 BP 238 EP 240 DI 10.1016/S1079-2104(96)80345-3 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA VH157 UT WOS:A1996VH15700005 PM 8884818 ER PT J AU Mael, FA Connerley, M Morath, RA AF Mael, FA Connerley, M Morath, RA TI None of your business: Parameters of biodata invasiveness SO PERSONNEL PSYCHOLOGY LA English DT Article; Proceedings Paper CT 10th Annual Conference of the Society-for-Industrial-and-Organizational-Psychology CY MAY, 1995 CL ORLANDO, FL SP Soc Ind & Org Psychol ID PRIVACY; PERCEPTIONS; DIMENSIONS; INVASION; SEX; LAW AB In this research, biodata items were evaluated for their perceived invasiveness by over 200 professionals (psychologists and social scientists), as well as three samples of nonprofessionals. In addition to item subject matter, perceived invasiveness of items was related to various biodata attributes, in that items that were more verifiable, more transparent in purpose, and more impersonal were seen as less invasive. Subjects with more positive attitudes toward biodata and organizational selection measures viewed fewer items as invasive, as did those with more education. Dispositional variables and gender were related to invasiveness perceptions in some samples. Four general motives or topics were determined to generate the greatest concern: fear of stigmatization, concern about having applicants recall traumatic events, intimacy, and religion. The results may help develop consensus about defining ''invasive'' and contribute to ways of reducing perceptions of invasiveness. C1 VIRGINIA TECH,BLACKSBURG,VA. GEORGE MASON UNIV,FAIRFAX,VA 22030. RP Mael, FA (reprint author), USA,RES INST,5001 EISENHOWER AVE,ALEXANDRIA,VA 22333, USA. NR 78 TC 19 Z9 19 U1 0 U2 6 PU PERSONNEL PSYCHOLOGY INC PI BOWLING GREEN PA 745 HASKINS ROAD, SUITE A, BOWLING GREEN, OH 43402 SN 0031-5826 J9 PERS PSYCHOL JI Pers. Psychol. PD FAL PY 1996 VL 49 IS 3 BP 613 EP 650 DI 10.1111/j.1744-6570.1996.tb01587.x PG 38 WC Psychology, Applied; Management SC Psychology; Business & Economics GA VH368 UT WOS:A1996VH36800004 ER PT J AU Williford, SL AF Williford, SL TI Water intoxication in patients treated with desmopressin - Reply SO PHARMACOTHERAPY LA English DT Editorial Material RP Williford, SL (reprint author), WOMACK ARMY MED CTR,DEPT PHARM,FT BRAGG,NC 28307, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU PHARMACOTHERAPY PUBLICATIONS INC PI BOSTON PA NEW ENGLAND MEDICAL CENTER BOX 806 171 HARRISON AVE, BOSTON, MA 02111 SN 0277-0008 J9 PHARMACOTHERAPY JI Pharmacotherapy PD SEP-OCT PY 1996 VL 16 IS 5 BP 970 EP 970 PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA VJ996 UT WOS:A1996VJ99600032 ER PT J AU Chen, JQ Krieger, JB Esquivel, RO Stott, MJ Iafrate, GJ AF Chen, JQ Krieger, JB Esquivel, RO Stott, MJ Iafrate, GJ TI Kohn-Sham effective potentials for spin-polarized atomic systems SO PHYSICAL REVIEW A LA English DT Article ID DENSITY-FUNCTIONAL THEORY; EXCHANGE-CORRELATION POTENTIALS; SELF-INTERACTION CORRECTION; UPSILON-REPRESENTABILITY; ELECTRON-DENSITIES; ISOELECTRONIC SEQUENCE; CORRELATION ENERGIES; MOMENTUM-SPACE; WAVE-FUNCTIONS; GROUND-STATE AB The Kohn-Sham effective potentials for selected lithium iso-electronic series (Z=3-10) and for the nitrogen atom have been obtained. Configuration interaction and the spin-unrestricted Hartree-Fock (SUHF) densities are used as input and the Kohn-Sham effective potentials for spin-majority and -minority channel are deduced, from which the exchange and correlation contributions are obtained. Accurate values are obtained for such quantities as exchange and exchange-correlation energies, Kohn-Sham orbital energies, and kinetic contributions to exchange and correlation energies. Comparison is made between the exchange potentials obtained from SUHF densities and from optimized effective potential calculations. The structure of the correlation potentials is discussed, and emphasis is put on how the potentials behave as functions of the electron density and the spin density. C1 UNIV AUTONOMA METROPOLITANA IZTAPALAPA, DEPT QUIM, IZTAPALAPA 09340, DF, MEXICO. QUEENS UNIV, DEPT PHYS, KINGSTON, ON K7L 3N6, CANADA. USA, RES OFF, RES TRIANGLE PK, NC USA. RP CUNY BROOKLYN COLL, DEPT PHYS, BROOKLYN, NY 11210 USA. NR 50 TC 14 Z9 14 U1 2 U2 9 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9926 EI 2469-9934 J9 PHYS REV A JI Phys. Rev. A PD SEP PY 1996 VL 54 IS 3 BP 1910 EP 1921 DI 10.1103/PhysRevA.54.1910 PG 12 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA VH090 UT WOS:A1996VH09000027 ER PT J AU Soln, J AF Soln, J TI Unification of interactions within the framework of polar coupling constants SO PHYSICS ESSAYS LA English DT Article DE coupling constants; unification of interactions; electroweak model; gauge coupling constants ID LEFT-RIGHT SYMMETRY; VIOLATION; MODEL AB The partial differential equations with respect to the polar rather than the (usual) Cartesian coupling constants for the S matrix are found to be useful for carrying out the unification of interactions. Particularly useful is the coupling constant integrability condition that allows the S matrix to be integrated in the n-dimensional coupling constant space with respect to just one coupling constant, the radial coupling constant. Here it is found that at least three types of unification exist: (1) the true unification when in the n interactions (with n coupling constants) the n spherical neutral vector bosons have absorbed n - 1 coupling angles, leaving the radial coupling constant as the only bonafide coupling parameter; (2) the partial true unification when in the m interactions (and coupling constants) the n spherical neutral vector bosons (n < m) have again absorbed n - 1 coupling angles, however leaving now in addition to the radial coupling constant also m - n coupling angles as bonafide coupling parameters; (3) the unified description of interactions (without involving the neutral vector bosons) in terms of the radial coupling constant, where, although passive, the coupling angles are still formally coupling parameters. Unlike in previous cases, here the coupling angles need not diagonalize the Lagrangian mass density terms. The spontaneously broken SU(2) x U(1) model (n = 2), which unifies electromagnetic and weak interactions, is an example of true unification. On the other hand, because the SU(3) quantum chromodynamics lacks the neutral vector boson, the SU(3) x SU(2) x U(1) gauge model (m = 3, n = 2) represents just the partial true unification of electromagnetic, weak, and strong interactions. Finally, interactions with gauge coupling constants (dimensionless in the natural system of units) can always be given a unified description. RP Soln, J (reprint author), USA,RES LAB,ADELPHI,MD 20783, USA. NR 30 TC 0 Z9 0 U1 0 U2 0 PU UNIV TORONTO PRESS INC PI TORONTO PA JOURNALS DIVISION, 5201 DUFFERIN ST, DOWNSVIEW, TORONTO ON M3H 5T8, CANADA SN 0836-1398 J9 PHYS ESSAYS JI Phys. Essays PD SEP PY 1996 VL 9 IS 3 BP 368 EP 379 PG 12 WC Physics, Multidisciplinary SC Physics GA VY954 UT WOS:A1996VY95400002 ER PT J AU Wood, JW Cortez, R Cahill, DG Stephenson, LD Zaghloul, HH AF Wood, JW Cortez, R Cahill, DG Stephenson, LD Zaghloul, HH TI UV spectroscopy of metal volatilization during thermal plasma processing of waste glass melts SO PLASMA CHEMISTRY AND PLASMA PROCESSING LA English DT Article DE spectroscopy; volatilization; iron; nickel; chromium; waste vitrification ID VOLUMETRIC EMISSION; ARGON; VAPORS; ARC; JET AB Atomic emission spectroscopy (AES) is used to monitor volatilization during waste vitrification with thermal plasmas. Model waste specimens consist of art aluminosilicate clay spiked with 10 wt.% Fe, Ni, or Cr. Specimens are vitrified in processing atmospheres with 0, 8.5, and 17 vol.% oxygen/argon concentrations. Particulate generated from condensation of the volatilized materials is collected following each specimen run and analyzed by energy dispersive X-ray analysis to determine composition. Spectra are collected from the ultraviolet range 240-380 nm where the presence of metal vapor is readily detected. Correlation between line emission intensities and volatilization rates allow's the establishment of provisional detection limits for the volatilization of Ni, Cr, Si, and Fe, of 1 x 10(-3) g/s, 4 x 10(-4) g/s, 2 x 10(-4) g/s, and 5 x 10(-5) g/s, respectively. The results of this investigation support the concept of using AES as an in-situ process monitor for feedback to optimize plasma processing of hazardous metal-containing waste. C1 USA,CONSTRUCT ENGN RES LABS,CHAMPAIGN,IL 61826. RP Wood, JW (reprint author), UNIV ILLINOIS,DEPT MAT SCI & ENGN,1304 W GREEN ST,URBANA,IL 61801, USA. RI Cahill, David/B-3495-2014 NR 24 TC 3 Z9 3 U1 0 U2 1 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0272-4324 J9 PLASMA CHEM PLASMA P JI Plasma Chem. Plasma Process. PD SEP PY 1996 VL 16 IS 3 BP 449 EP 460 DI 10.1007/BF01447155 PG 12 WC Engineering, Chemical; Physics, Applied; Physics, Fluids & Plasmas SC Engineering; Physics GA VK364 UT WOS:A1996VK36400009 ER PT J AU Raines, EF AF Raines, EF TI ''We have just begun to not fight'': An oral history of conscientious objectors in civilian public service during World War II - Frazer,HT, OSullivan,J SO POLITICAL SCIENCE QUARTERLY LA English DT Book Review RP Raines, EF (reprint author), USA,CTR MIL HIST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU ACAD POLITICAL SCIENCE PI NEW YORK PA 475 RIVERSIDE DRIVE, SUITE 1274, NEW YORK, NY 10115-1274 SN 0032-3195 J9 POLIT SCI QUART JI Polit. Sci. Q. PD FAL PY 1996 VL 111 IS 3 BP 560 EP 561 DI 10.2307/2152001 PG 2 WC Political Science SC Government & Law GA VN084 UT WOS:A1996VN08400037 ER PT J AU Soules, DB Drexler, JJ Draayer, BF Eaton, FD Hines, JR AF Soules, DB Drexler, JJ Draayer, BF Eaton, FD Hines, JR TI Exposure-time effects on differential r(0) measurements SO PUBLICATIONS OF THE ASTRONOMICAL SOCIETY OF THE PACIFIC LA English DT Article AB Experimental results are presented indicating a causal effect between exposure time of the detection system and variations in measured differential stellar image motion. The variability is also dependent on atmospheric winds encountered along the entire propagation path at the precise time of measurement, making explicit comparison of experimental results with theory impractical. Earlier theoretical development is recast in terms of Fried's seeing parameter, r(0), and collected data are tested for conformance to stationarity criteria. It is recommended that atmospheric turbulence seeing monitors based on differential image motion measurements be restricted to exposure times of not more than 2 ms. C1 USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP Soules, DB (reprint author), LOCKHEED MARTIN SYST SUPPORT SERV,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 24 TC 7 Z9 9 U1 2 U2 3 PU ASTRONOMICAL SOC PACIFIC PI SAN FRANCISCO PA 390 ASHTON AVE, SAN FRANCISCO, CA 94112 SN 0004-6280 J9 PUBL ASTRON SOC PAC JI Publ. Astron. Soc. Pac. PD SEP PY 1996 VL 108 IS 727 BP 817 EP 827 DI 10.1086/133801 PG 11 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA VG555 UT WOS:A1996VG55500006 ER PT J AU Houminer, Z Soicher, H AF Houminer, Z Soicher, H TI Improved short-term predictions of f(0)F(2) using GPS time delay measurements SO RADIO SCIENCE LA English DT Article ID SATELLITE AB Reliable HF communications along short-, medium- and long-range paths require propagation assessment. Such assessment could be facilitated with the monitoring of ionospheric characteristics by continuously available passive means, i.e., measurement of the total electron content (TEC) using satellite-emitted signals without a need for burdening the electromagnetic spectrum. With ubiquitous Global Positioning System (GPS) providing instantaneous time delay, or equivalently, TEC, values when needed, an assessment of HF propagation conditions may be available on a near-real-time basis. Both TEC and the peak electron density of the ionosphere, which determines the ordinary upper frequency limit (f(o)F(2)) for HF sky wave vertical propagation, vary strongly with solar and geomagnetic parameters. Their ratio, the equivalent slab thickness, may vary to a lesser degree and hence be modeled with greater accuracy. A slab thickness model combined with real-time TEC measurement anywhere on the globe may possibly yield an improved HF parameter prediction algorithm. To test the efficacy of the hypothesis, one has to ascertain the correlation, as exhibited by the correlation coefficient, between the TEC daily variability about the monthly mean and the f(o)F(2) variability. To determine such correlation, a study compared Faraday TEC data as well as GPS-generated TEC data collected in Israel and with corresponding f(o)F(2) values obtained from vertical sounder measurements near the appropriate subionospheric location in Cyprus. The analysis shows that for large percentages of the time, very good correlation exists between TEC and f(o)F(2) short-term variations. The correlation coefficient varies between 0.7 or better during winter and summer months to about 0.5-0.6 during equinox months. A study of the diurnal dependence of the correlation indicates that a better correlation exists during daytime than nighttime. There was no indication that the coefficient is dependent on geomagnetic activity or on protonospheric electron content during the period of this study. C1 USA,COMMUN ELECT COMMAND,SPACE & TERR COMMUN DIRECTORATE,AA,WL,ST,RD,AMSEL,FT MONMOUTH,NJ 07703. RP Houminer, Z (reprint author), TECHNION ISRAEL INST TECHNOL,ASHER SPACE RES INST,IL-32000 HAIFA,ISRAEL. NR 12 TC 29 Z9 31 U1 0 U2 0 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0048-6604 J9 RADIO SCI JI Radio Sci. PD SEP-OCT PY 1996 VL 31 IS 5 BP 1099 EP 1108 DI 10.1029/96RS01965 PG 10 WC Astronomy & Astrophysics; Geochemistry & Geophysics; Meteorology & Atmospheric Sciences; Remote Sensing; Telecommunications SC Astronomy & Astrophysics; Geochemistry & Geophysics; Meteorology & Atmospheric Sciences; Remote Sensing; Telecommunications GA VK772 UT WOS:A1996VK77200009 ER PT J AU Murphey, MD Andrews, CI Flemming, DJ Temple, HT Smith, WS Smirniotopoulos, JG AF Murphey, MD Andrews, CI Flemming, DJ Temple, HT Smith, WS Smirniotopoulos, JG TI From the archives of the AFIP - Primary tumors of the spine: Radiologic-pathologic correlation SO RADIOGRAPHICS LA English DT Article DE bones, cysts; bones, growth and development; chordoma; ewing sarcoma; osteoblastoma; osteochondroma; osteoma; osteosarcoma; sarcoma; spine, primary neoplasms ID ANEURYSMAL BONE-CYST; PRIMARY EWINGS-SARCOMA; HEREDITARY MULTIPLE EXOSTOSES; PRIMARY OSTEOGENIC-SARCOMA; OSTEOID OSTEOMA; CERVICAL-SPINE; COMPUTED-TOMOGRAPHY; LUMBAR SPINE; SACROCOCCYGEAL CHORDOMA; ISLAND ENOSTOSIS AB Primary tumors of the spine are relatively infrequent lesions compared with metastatic disease, multiple myeloma, and lymphoma. However, when a solitary lesion of the spine occurs, these neoplasms represent an important group of entities for diagnostic consideration. A wide variety of benign neoplasms can involve the spine, including osteoid osteoma, osteoblastoma, aneurysmal bone cyst, giant cell tumor, enostosis, and osteochondroma. Common primary nonlymphoproliferative malignant neoplasms of the spine include chordoma, chondrosarcoma, Ewing sarcoma or primitive neuroectodermal tumor, and osteosarcoma, The imaging features of these lesions of the spine are often characteristic, These changes include a small sclerotic focus with irregular thorny margins in the vertebral body (enostosis), a small radiolucent nidus with central calcification in the posterior elements of the vertebral body (osteoid osteoma), a large expansile lesion with multiple fluid-fluid levels (aneurysmal bone cyst), and an aggressive mineralized mass (chondroid or osteoid) with osseous and soft-tissue involvement (chondrosarcoma or osteosarcoma). Radiologists should be aware of the appearance of these unusual neoplasms in order to provide a complete differential diagnosis and to guide clinical colleagues in patient treatment. C1 UNIFORMED SERV UNIV HLTH SCI, DEPT RADIOL & NUCL MED, BETHESDA, MD 20814 USA. UNIFORMED SERV UNIV HLTH SCI, DEPT SURG, BETHESDA, MD 20814 USA. UNIV MARYLAND, MED CTR, DEPT RADIOL, BALTIMORE, MD 21201 USA. NATL NAVAL MED CTR, BETHESDA, MD 20889 USA. VET ADM MED CTR, AUGUSTA, GA 30904 USA. MED COLL GEORGIA, AUGUSTA, GA 30912 USA. WALTER REED ARMY MED CTR, DEPT SURG, ORTHOPED SERV, WASHINGTON, DC 20307 USA. RP Murphey, MD (reprint author), ARMED FORCES INST PATHOL, DEPT RADIOL PATHOL, 6825 16TH ST NW, ROOM M-133A, WASHINGTON, DC 20306 USA. RI Smirniotopoulos, James/D-3726-2011 NR 84 TC 116 Z9 120 U1 0 U2 2 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0271-5333 J9 RADIOGRAPHICS JI Radiographics PD SEP PY 1996 VL 16 IS 5 BP 1131 EP 1158 PG 28 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA VK251 UT WOS:A1996VK25100013 PM 8888395 ER PT J AU Johnson, KB Wiesmann, WP Pearce, FJ AF Johnson, KB Wiesmann, WP Pearce, FJ TI The effect of hypothermia on potassium and glucose changes in isobaric hemorrhagic shock in the rat SO SHOCK LA English DT Article ID CIRCULATORY ARREST; OXYGEN DELIVERY; DOGS; SURVIVAL; PHASE AB Hypothermia has been shown to decrease oxygen consumption requirements and improve survival during hemorrhagic shock. However, hypothermia applied therapeutically does not prevent the development of a lactic acidosis during hemorrhage, We re-examined the development of a hemorrhage-induced lactic acidosis and other metabolic parameters (glucose, plasma electrolytes, and arterial blood gases) at various temperatures (29-37 degrees C) to better define the protective action of hypothermia in hemorrhagic shock, Five groups of male, Sprague-Dawley rats were bled to a mean arterial blood pressure (MABP) of 40 mmHg over a 15 min period and held there by further blood removal until death, The final level and rate of development of the lactic acidemia was the same in all groups, However, the rate of decline in plasma glucose and rate of rise in plasma potassium were temperature dependent. These results suggest that temperature-dependent changes in serum glucose and potassium may contribute to the protective effect of hypothermia during hemorrhagic shock. C1 WALTER REED ARMY INST RES,DIV SURG,WASHINGTON,DC 20307. NR 23 TC 16 Z9 17 U1 0 U2 1 PU BIOMEDICAL PRESS PI AUGUSTA PA 1021 15TH ST, BIOTECH PARK STE 9, AUGUSTA, GA 30901 SN 1073-2322 J9 SHOCK JI Shock PD SEP PY 1996 VL 6 IS 3 BP 223 EP 229 DI 10.1097/00024382-199609010-00012 PG 7 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA VH156 UT WOS:A1996VH15600012 PM 8885090 ER PT J AU Swami, A AF Swami, A TI Cramer-Rao bounds for deterministic signals in additive and multiplicative noise SO SIGNAL PROCESSING LA English DT Article ID PARAMETER-ESTIMATION; RANDOM AMPLITUDE; PHASE AB We derive expressions for the Cramer-Rao Bound (CRB) for the estimates of the parameters of a deterministic signal observed in additive and multiplicative noise which may be i.i.d. non-Gaussian or colored Gaussian. General expressions for the CRB are derived, and are then applied to the specific case of polynomial phase signals for which closed-form expressions are obtained under certain assumptions, We also develop bounds on the CRB; these bounds are tight at low SNR. C1 USA,RES LAB,AMSRL IS TA,ADELPHI,MD 20783. NR 24 TC 38 Z9 38 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-1684 J9 SIGNAL PROCESS JI Signal Process. PD SEP PY 1996 VL 53 IS 2-3 BP 231 EP 244 DI 10.1016/0165-1684(96)00088-6 PG 14 WC Engineering, Electrical & Electronic SC Engineering GA VQ585 UT WOS:A1996VQ58500011 ER PT J AU Hamilton, JA Ratterree, GR Brutch, PC Pooch, UW AF Hamilton, JA Ratterree, GR Brutch, PC Pooch, UW TI Public domain tools for modeling and simulating computer networks SO SIMULATION LA English DT Article DE NetSim; network simulation; network modeling; asynchronous transfer mode; MaRS AB Simulation of computer networks is an area of growing interest. Network simulation is a multidisciplinary endeavor requiring expertise in computer networking, modeling and simulation, and software engineering. Network modeling and simulation tools in the research community provide important exemplar technology that has the potential for reuse. NetSim, developed at the Massachusetts Institute of Technology, is an excellent example of a network simulation infrastructure that can support a variety of modifications. In this paper we discuss NetSim and- two additional tools: the Maryland Routing Simulator and the Texas A&M Asynchronous Transfer Mode Simulator, which are both modifications of NetSim. NetSim can serve as a simple but effective Ethernet or point-to-point network simulator. Additionally, NetSim can serve as a rapid prototyping tool for other network simulators. C1 PARANET,DALLAS,TX 75240. TEXAS A&M UNIV,DEPT COMP SCI,COLLEGE STN,TX 77843. RP Hamilton, JA (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 12 TC 1 Z9 1 U1 0 U2 0 PU SIMULATION COUNCILS INC PI SAN DIEGO PA PO BOX 17900, SAN DIEGO, CA 92117 SN 0037-5497 J9 SIMULATION JI Simulation PD SEP PY 1996 VL 67 IS 3 BP 161 EP 169 DI 10.1177/003754979606700303 PG 9 WC Computer Science, Interdisciplinary Applications; Computer Science, Software Engineering SC Computer Science GA WL563 UT WOS:A1996WL56300003 ER PT J AU Will, MJ Hecker, RB Wathen, PI AF Will, MJ Hecker, RB Wathen, PI TI Primary varicella-zoster-induced rhabdomyolysis SO SOUTHERN MEDICAL JOURNAL LA English DT Article ID MYOGLOBINURIA AB Acute rhabdomyolysis after uncomplicated, primary varicella-zoster infection is a rare condition that is sparsely reported in the literature. We report a case of acute rhabdomyolysis due to varicella-zoster infection and review the literature regarding the etiology, diagnosis, and management of this potentially life-threatening condition, Rapid recognition, along with appropriate treatment, should result in an excellent recovery without adverse sequelae. C1 BROOKE ARMY MED CTR,DEPT ANESTHESIOL & CRIT CARE SERV,FT SAM HOUSTON,TX 78234. UNIV TEXAS,HLTH SCI CTR,DEPT INTERNAL MED,SAN ANTONIO,TX. RP Will, MJ (reprint author), BROOKE ARMY MED CTR,DEPT ORAL & MAXILLOFACIAL SURG,MCNK,OS,1950 STANLEY RD,FT SAM HOUSTON,TX 78234, USA. NR 15 TC 10 Z9 10 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD SEP PY 1996 VL 89 IS 9 BP 915 EP 920 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA VG207 UT WOS:A1996VG20700015 PM 8790319 ER PT J AU LeClaire, RD Hunt, RE Bavari, S Estep, JE Nelson, GO Wilhelmsen, CL AF LeClaire, RD Hunt, RE Bavari, S Estep, JE Nelson, GO Wilhelmsen, CL TI Potentiation of inhaled staphylococcal enterotoxin B-induced toxicity by lipopolysaccharide in mice SO TOXICOLOGIC PATHOLOGY LA English DT Article DE superantigen; inhalation; pulmonary edema; shock; mouse; nonhuman primate ID TUMOR-NECROSIS-FACTOR; T-CELLS; LETHAL SHOCK; GAMMA-INTERFERON; CYTOKINE RELEASE; SUPERANTIGENS; MHC; MOLECULES; STIMULATION; ACTIVATION AB Nonhuman primates are the established model for evaluating toxic responses to staphylococcal enterotoxins (SEs), as they react similarly to humans. Rodents are generally considered unresponsive to SEs. Binding affinities and T-cell reactivity suggest that SE binds more efficiently to primate major histocompatability complex class II receptors than to mouse receptors. We investigated the potentiation of staphylococcal enterotoxin B (SEB) inhalation toxicity by lipopolysaccharide (LPS) in BALB/c mice. Lethality occurred only when SEB was potentiated by LPS. Neither SEB nor LPS produced lethal effects alone. Temporal responses of interleukin 1 alpha, tumor necrosis factor alpha, interleukin 2, and interferon-gamma evoked by inhaled SEB were enhanced by LPS. By 24 hr after intoxication, serum cytokines decreased to baseline levels, and consistent pulmonary perivascular leukocytic infiltrates were evident histologically. Histologic lesions induced by inhalation exposure to SEB by mice, with or without potentiation by LPS, were similar to those in the rhesus monkey. Predominant pulmonary lesions included severe, diffuse interstitial and alveolar pulmonary edema, leukocytic infiltrates, mild perivascular edema, and alveolar fibrin deposition. Although the mechanism of aerosolized SEB-induced toxicity has not been completely resolved, similarities in histologic lesions, cytokine responses, and acute dose-response suggest the LPS-potentiated mouse model may be a credible alternative to the nonhuman primate model. RP LeClaire, RD (reprint author), USA,BIOL SYST DIV,FREDERICK,MD 21702, USA. NR 36 TC 15 Z9 17 U1 0 U2 2 PU SOC TOXICOLOGIC PATHOLOGISTS PI LAWRENCE PA 1041 NEW HAMPSHIRE ST PO BOX 368, LAWRENCE, KS 66044 SN 0192-6233 J9 TOXICOL PATHOL JI Toxicol. Pathol. PD SEP-OCT PY 1996 VL 24 IS 5 BP 619 EP 626 PG 8 WC Pathology; Toxicology SC Pathology; Toxicology GA VR345 UT WOS:A1996VR34500013 PM 8923684 ER PT J AU Jorgenson, DS Centeno, JA Mayer, MH Topper, MJ Mullick, FG Manson, PN AF Jorgenson, DS Centeno, JA Mayer, MH Topper, MJ Mullick, FG Manson, PN TI ''Have you seen this?'' Leukocyte response to titanium implants SO TOXICOLOGIC PATHOLOGY LA English DT Article RP Jorgenson, DS (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307, USA. NR 4 TC 1 Z9 1 U1 0 U2 0 PU SOC TOXICOLOGIC PATHOLOGISTS PI LAWRENCE PA 1041 NEW HAMPSHIRE ST PO BOX 368, LAWRENCE, KS 66044 SN 0192-6233 J9 TOXICOL PATHOL JI Toxicol. Pathol. PD SEP-OCT PY 1996 VL 24 IS 5 BP 664 EP 665 PG 2 WC Pathology; Toxicology SC Pathology; Toxicology GA VR345 UT WOS:A1996VR34500028 PM 8923696 ER PT J AU Poli, MA Rivera, VR Pitt, ML Vogel, P AF Poli, MA Rivera, VR Pitt, ML Vogel, P TI Aerosolized specific antibody protects mice from lung injury associated with aerosolized ricin exposure SO TOXICON LA English DT Article ID CLEARANCE AB Parenteral vaccination with ricin toroid, although protective against death after a lethal aerosol ricin challenge, only partially protects against lung lesions. Therefore, we tested whether passive protection with aerosolized specific anti-ricin IgG (goat polyclonal, affinity-purified) could protect against both lethality and lung lesions in unvaccinated mice. Healthy CD-1 mice were administered antibody (Ab) by small particle aerosol. Group 1 received non-specific control Ab (2160 mg/min/m(3)), and groups 2 and 3 received anti-ricin IgG (960 and 3280 mg/min/m(3), respectively). Each group was challenged with a lethal dose of aerosolized ricin 1 hr after Ab exposure. All group 1 (control Ab) mice developed diffuse airway epithelial necrosis, with severe interstitial edema and inflammation involving all lung lobes, and died 48-96 hr post-challenge (PC). In contrast, in groups 2 and 3 at 24 hr PC, lung lesions were absent to very mild although there was rare epithelial necrosis in the upper airways in both groups. By 48 hr PC, necrosis of the tracheal epithelium and peritracheal inflammation were noted in some group 3 mice only. By 4 days PC, lungs and airways did not differ from cage controls in most group 2 and 3 mice. Weight gain in group 2 and 3 mice paralleled that of control mice. At 14 days PC, lungs were no different in controls than in group 3 mice. However, two non-survivors in group 3 had obstructions due to proximal airway epithelial damage. All group 2 mice survived, although a mild lymphoplasmacytic perivasculitis was present at 14 days PC which was not noted in the group 3 mice. Published by Elsevier Science Ltd C1 USA,MED RES INST INFECT DIS,DIV PATHOL,FREDERICK,MD 21702. RP Poli, MA (reprint author), USA,MED RES INST INFECT DIS,DIV TOXICOL,FT DETRICK,FREDERICK,MD 21702, USA. NR 10 TC 35 Z9 37 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD SEP PY 1996 VL 34 IS 9 BP 1037 EP 1044 DI 10.1016/0041-0101(96)00047-5 PG 8 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA VL390 UT WOS:A1996VL39000007 PM 8896195 ER PT J AU Nontprasert, A Pukrittayakamee, S Kyle, DE Vanijanonta, S White, NJ AF Nontprasert, A Pukrittayakamee, S Kyle, DE Vanijanonta, S White, NJ TI Antimalarial activity and interactions between quinine, dihydroquinine and 3-hydroxyquinine against Plasmodium falciparum in vitro SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article DE malaria; Plasmodium falciparum; chemotherapy; quinine; dihydroquinine; 3-hydroxyquinine ID PERFORMANCE LIQUID-CHROMATOGRAPHY; WHOLE-BLOOD; RESISTANCE; QUINIDINE; MALARIA; PLASMA AB The antimalarial activities of quinine, dihydroquinine (a natural impurity found in commercial pharmaceutical formulations of quinine) and 3-hydroxyquinine (the principal metabolite of quinine in humans) were tested both individually and in pairs against 5 strains of Plasmodium falciparum isolated from patients in Thailand. The median inhibitory concentrations (IC50) were similar for quinine (168 nmol/L, range 68 - 366), and dihydroquinine (129 nmol/L, range 54 - 324), and both were significantly lower than that of 3-hydroxyquinine (1160 nmol/L, range 378 - 3154) (P = 0.027). When these drugs were tested in combination, there was no evidence of synergy or antagonism, as determined by fractionary inhibitory indices and isobolograms. Quinine and its impurity, dihydroquinine, have equivalent antimalarial activities which are approximately 10 times greater than that of the metabolite 3-hydroxyquinine. These 2 compounds, which are not usually measured in specific drug assays, contribute to antimalarial activity after quinine administration. C1 MAHIDOL UNIV,FAC TROP MED,HOSP TROP DIS,BANGKOK 10400,THAILAND. JOHN RADCLIFFE HOSP,NUFFIELD DEPT CLIN MED,OXFORD OX3 9DU,ENGLAND. ARMED FORCES RES INST MED SCI,BANGKOK 10400,THAILAND. RI White, Nicholas/I-4629-2012 FU Wellcome Trust NR 15 TC 9 Z9 10 U1 0 U2 0 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON, ENGLAND W1N 4EY SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD SEP-OCT PY 1996 VL 90 IS 5 BP 553 EP 555 DI 10.1016/S0035-9203(96)90320-X PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA VP901 UT WOS:A1996VP90100025 PM 8944272 ER PT J AU Alving, BM Weinstein, MJ Finlayson, JS Fratantoni, JC AF Alving, BM Weinstein, MJ Finlayson, JS Fratantoni, JC TI Further information on the fibrin sealant conference SO TRANSFUSION LA English DT Letter C1 US FDA,CTR BIOL EVALUAT & RES,BETHESDA,MD. RP Alving, BM (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307, USA. NR 1 TC 3 Z9 3 U1 0 U2 0 PU AMER ASSOC BLOOD BANKS PI BETHESDA PA 8101 GLENBROOK RD, BETHESDA, MD 20814-2749 SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 1996 VL 36 IS 9 BP 845 EP 846 PG 2 WC Hematology SC Hematology GA VJ087 UT WOS:A1996VJ08700019 ER PT J AU Casleton, BG Salata, KF Strickman, D Chan, TC Kelly, DJ AF Casleton, BG Salata, KF Strickman, D Chan, TC Kelly, DJ TI Persistence of Orientia tsutsugamushi in stored packed red blood cells. SO TRANSFUSION LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. USN,MED RES INST,BETHESDA,MD. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC BLOOD BANKS PI BETHESDA PA 8101 GLENBROOK RD, BETHESDA, MD 20814-2749 SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 1996 VL 36 IS 9 SU S BP S224 EP S224 PG 1 WC Hematology SC Hematology GA VK089 UT WOS:A1996VK08900224 ER PT J AU Fryar, RA Tran, K Kapoor, V Stromberg, RR AF Fryar, RA Tran, K Kapoor, V Stromberg, RR TI Accuracy of leukocyte assays for red cell units stored prior to leukoreduction. SO TRANSFUSION LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. AMER RED CROSS,ROCKVILLE,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC BLOOD BANKS PI BETHESDA PA 8101 GLENBROOK RD, BETHESDA, MD 20814-2749 SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 1996 VL 36 IS 9 SU S BP S49 EP S49 PG 1 WC Hematology SC Hematology GA VK089 UT WOS:A1996VK08900049 ER PT J AU Kress, MR Graves, MR Bourne, SG AF Kress, MR Graves, MR Bourne, SG TI Loss of bottomland hardwood forests and forested wetlands in the Cache River Basin, Arkansas SO WETLANDS LA English DT Article DE geographic information systems; GIS; remote sensing; image processing; change assessment; forested wetlands; bottomland hardwood; Cache River; Arkansas AB Data related to forest cover in the Cache River Basin, Arkansas, USA were collected and analyzed to quantify changes in forest cover since 1935. Forest cover loss during the period 1935 to 1987 was characterized using data derived from aerial photography, historical map products, and Landsat satellite multispectral imagery. Forest cover in the basin declined from 65% to 15% over the 52-year period (a loss of 108,000 ha of forest cover). There was little change in forest cover between 1975 and 1987. Remaining forest stands in the basin are fragmented and small in size. Comparing forest-stand data with Soil Conservation Service data revealed that 90% of the forest loss in the southern half of the basin occurred in hydric soil areas, thus indicating a significant loss of forested wetlands. C1 DYNCORP,VICKSBURG,MS 39180. RP Kress, MR (reprint author), USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 23 TC 13 Z9 14 U1 0 U2 2 PU SOC WETLAND SCIENTISTS PI LAWRENCE PA 810 E TENTH ST, P O BOX 1897, LAWRENCE, KS 66044 SN 0277-5212 J9 WETLANDS JI Wetlands PD SEP PY 1996 VL 16 IS 3 BP 258 EP 263 PG 6 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA VK499 UT WOS:A1996VK49900002 ER PT J AU Smith, RD AF Smith, RD TI Composition, structure, and distribution of woody vegetation on the Cache River Floodplain, Arkansas SO WETLANDS LA English DT Review DE forested wetlands; floodplains; bottomland hardwoods; cypress tupelo; structural characteristics; species-environment relationships; multivariate analysis; correspondence analysis; canonical correspondence analysis; classification; two-way indicator species analysis ID CANONICAL CORRESPONDENCE-ANALYSIS; DETRENDED CORRESPONDENCE-ANALYSIS; FORESTED WETLAND; PUTTING THINGS; ENVIRONMENT RELATIONSHIPS; SOUTHERN ILLINOIS; GRADIENT ANALYSIS; COASTAL-PLAIN; SWAMP-FOREST; PATTERNS AB This study characterizes the species composition, structure, and distribution of woody plants on the floodplain of the Cache River in northeastern Arkansas. Trees, saplings, and shrubs were sampled in 249 plots along with 28 environmental variables. Classification of the plots resulted in four forest dominance types being identified. The basal area, density, species richness, and diversity of these four types were within the range of values established for similar floodplain forests throughout the Coastal Plain of the southeastern United States. Canonical correspondence analysis revealed the distribution of species to be significantly correlated with flood depth and flood duration as well as geomorphic position and soil texture. RP Smith, RD (reprint author), USA,ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 101 TC 21 Z9 22 U1 3 U2 14 PU SOC WETLAND SCIENTISTS PI LAWRENCE PA 810 E TENTH ST, P O BOX 1897, LAWRENCE, KS 66044 SN 0277-5212 J9 WETLANDS JI Wetlands PD SEP PY 1996 VL 16 IS 3 BP 264 EP 278 PG 15 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA VK499 UT WOS:A1996VK49900003 ER PT J AU Killgore, KJ Baker, JA AF Killgore, KJ Baker, JA TI Patterns of larval fish abundance in a bottomland hardwood wetland SO WETLANDS LA English DT Article DE forested wetlands; larval fish; reproduction; hydrology; floodplain ID RIVER; ECOSYSTEMS AB Larval fishes were collected with light traps and ichthyoplankton nets for two consecutive years during spring and early summer in the channel and floodplain (tupelo and oak forest) of the Cache River, Arkansas. A total of 8,113 individuals were collected between the two gears. Twenty-eight species were confirmed, but total number of taxa, including genus and family level groupings, was 35. Pirate perch (Aphredoderus sayanus) was the most abundant species, with 21% of the total catch consisting of this fish. Percidae (darters) was the dominant family, comprising at least seven species and accounting for 57% of the total numbers of fish collected. The families Cyprinidae and Centrarchidae were also common. Specimens that could not be identified to species made up nearly 56% of the catch. Species richness was similar among the three habitats probably due to hydraulic mixing, but individuals in the families Centrarchidae, Cyprinidae, and Percidae were more abundant in tupelo and oak habitats than in channel for net and light trap catches. Mean catch of total individuals in nets and light traps was greater in floodplain habitats than in the channel, particularly during spring 1989. Large catches in spring 1989 corresponded to higher water levels that expanded the aquatic/oak forest transition zone compared to lower water levels in 1988. Thus, late winter and spring floods that inundate the oak forest appear to be a major factor in regulating abundance of larval fishes in this bottomland hardwood wetland. RP Killgore, KJ (reprint author), USA,ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 40 TC 22 Z9 23 U1 1 U2 6 PU SOC WETLAND SCIENTISTS PI LAWRENCE PA 810 E TENTH ST, P O BOX 1897, LAWRENCE, KS 66044 SN 0277-5212 J9 WETLANDS JI Wetlands PD SEP PY 1996 VL 16 IS 3 BP 288 EP 295 PG 8 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA VK499 UT WOS:A1996VK49900005 ER PT J AU Wakeley, JS Roberts, TH AF Wakeley, JS Roberts, TH TI Bird distributions and forest zonation in a bottomland hardwood wetland SO WETLANDS LA English DT Article DE bird diversity; bird populations; wildlife habitat; forested wetlands; wetland functions; bottomland hardwoods; forest zonation; wetness gradient; Cache River; Arkansas ID CANONICAL CORRESPONDENCE-ANALYSIS; GRADIENT ANALYSIS; BREEDING BIRDS; HABITAT AB During spring of 1988 and winter of 1988-89, we sampled songbird populations and habitat characteristics along two belt transects extending across the broad, forested floodplain of the Cache River, Arkansas, USA. Objectives were to compare avian abundance and species richness among floodplain forest zones and to investigate bird species distributions in relation to the wetness gradient. Forest zones differed in structure, flooding regime, and use by birds. The tupelo/baldcypress zone, in particular, provided habitat unlike that in the higher oak-dominated zones and supported a number of bird species that were much less abundant elsewhere. Distributions of chimney swifts (Chaetura pelagica), prothonotary warblers (Protonotaria citrea), and great crested flycatchers (Myiarchus crinitus) were skewed toward wetter sites, whereas summer tanagers (Piranga rubra), red-eyed vireos (Vireo olivaceus), and others were skewed toward drier sites. RP USA, ENGINEER WATERWAYS EXPT STN, ENVIRONM LAB, 3909 HALLS FERRY RD, VICKSBURG, MS 39180 USA. NR 41 TC 15 Z9 16 U1 2 U2 15 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0277-5212 EI 1943-6246 J9 WETLANDS JI Wetlands PD SEP PY 1996 VL 16 IS 3 BP 296 EP 308 PG 13 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA VK499 UT WOS:A1996VK49900006 ER PT J AU DeLaune, RD Boar, RR Lindau, CW Kleiss, BA AF DeLaune, RD Boar, RR Lindau, CW Kleiss, BA TI Denitrification in bottomland hardwood wetland soils of the Cache River SO WETLANDS LA English DT Article DE bottomland hardwoods; Cache River; denitrification; nitrogen; nitrification; soil carbon ID FRESH-WATER; NITRATE REDUCTION; MARINE ECOSYSTEMS; FORESTED WETLAND; NITRIFICATION; SEDIMENTS; ESTUARINE; DILUTION; SWAMP; RATES AB Denitrification rates were quantified in bottomland hardwood wetland soils of the Cache River. N-15 labeled nitrate was added to columns containing wetland soils and river water. Over 40 days, nitrate-N in floodwater (approximately 9 mg N L(-1)) decreased by between 82% and 59%, which gave estimates of N export from the water column of between 11.5 mg N m(-2) day(-1) and 7.5 mg N m(-2) day(-1). These values correlated directly with organic content of surface sediment, which included forest litter. Added glucose doubled rates of nitrate loss in these soils, which indicated that the process was carbon limited. Nitrification occurring simultaneously with denitrification was determined using isotopic dilution techniques. Contributions of nitrate to water from nitrification were estimated at between 5% and 12% of the total nitrate reduced. Rates of nitrogen transformation in these forest soils were likely limited by available soil carbon from tree litter and perhaps canopy leachate, rather than by nitrate concentration in inflowing floodwater. C1 USA,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39182. RP DeLaune, RD (reprint author), LOUISIANA STATE UNIV,WETLAND BIOGEOCHEM INST,BATON ROUGE,LA 70803, USA. RI DeLaune, R.D./A-2058-2012 NR 27 TC 20 Z9 20 U1 2 U2 8 PU SOC WETLAND SCIENTISTS PI LAWRENCE PA 810 E TENTH ST, P O BOX 1897, LAWRENCE, KS 66044 SN 0277-5212 J9 WETLANDS JI Wetlands PD SEP PY 1996 VL 16 IS 3 BP 309 EP 320 PG 12 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA VK499 UT WOS:A1996VK49900007 ER PT J AU Kleiss, BA AF Kleiss, BA TI Sediment retention in a bottomland hardwood wetland in Eastern Arkansas SO WETLANDS LA English DT Article DE sedimentation; vertical accretion; bottomland hardwoods; wetland functions; forested wetlands; Arkansas ID RAPIDLY SUBSIDING WETLAND; CANAL IMPACTS; ACCRETION; MARSH AB One of the often-stated functions of wetlands is their ability to remove sediments and other particulates from water, thus improving water quality in the adjacent aquatic system. However, actual rates of suspended sediment removal have rarely been measured in freshwater wetland systems. To address this issue, suspended sediment dynamics were measured in a 85-km(2) bottomland hardwood (BLH) wetland adjacent to the highly turbid Cache River in eastern Arkansas during the 1988-1990 water years. A suspended sediment mass balance was calculated using depth-integrated, flow-weighted daily measurements at wetland inflow and outflow points. Over the three-year period, suspended sediment load decreased an average of 14% between upstream and downstream sampling points. To test the idea that the suspended sediments were retained by the adjacent wetland and to determine what portion of the BLH forest was most responsible for retaining the suspended sediments, concurrent measurements of sediment accretion were made at 30 sites in the wetland using feldspar clay marker horizons, sedimentation disks, the (137)cesium method, and dendrogeomorphic techniques. Sedimentation rates exceeding 1 cm/yr were measured in frequently flooded areas dominated by Nyssa aquatica and Taxodium distichum. Maximum sedimentation rates did not occur on the natural levee, as would be predicted by classical fluvial geomorphology, but in the ''first bottom,'' where retention time of the water reached a maximum. Multiple regression was used to relate sedimentation rates with several physical and biological factors. A combination of distance from the river, flood duration, and tree basal area accounted for nearly 90% of the variation in sedimentation rates. RP Kleiss, BA (reprint author), USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 29 TC 75 Z9 75 U1 1 U2 10 PU SOC WETLAND SCIENTISTS PI LAWRENCE PA 810 E TENTH ST, P O BOX 1897, LAWRENCE, KS 66044 SN 0277-5212 J9 WETLANDS JI Wetlands PD SEP PY 1996 VL 16 IS 3 BP 321 EP 333 PG 13 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA VK499 UT WOS:A1996VK49900008 ER PT J AU Dortch, MS AF Dortch, MS TI Removal of solids, nitrogen, and phosphorus in the Cache River Wetland SO WETLANDS LA English DT Article DE bottomland hardwood wetland; first-order removal model; suspended solids; nitrogen; phosphorus; removal efficiency; removal rate constants ID RETENTION AB Mass flux measurements collected between April 1987 and September 1990 at the upstream and downstream boundaries of the Cache River Wetland (CRW), a bottomland hardwood forest in eastern AR kansas, were used to estimate long-term, average removal efficiencies (RE, %) for inorganic suspended solids (ISS), total nitrogen (TN), and total phosphorus (TP). The observed removal efficiencies were used with a steady-state, first-order removal model to compute removal rate constants. Detention time of the CRW was determined with a time-varying, two-dimensional, depth-averaged, numerical Bow and transport model. The computed average detention time of 5.02 da was close to the average hydraulic retention time of 5.15 da, justifying the plug flow assumption of the model. The removal rate constants estimated from the CRW data for ISS, TN, and TP were 0.066 m/da, 0.048 da(-1), and 0.0058 m/da (2.1 m/yr), respectively. The denitrification rate constant estimated for the CRW was 0.24 da(-1). These rate constants are in general agreement with values obtained from the literature. RP Dortch, MS (reprint author), USA, ENGINEER WATERWAYS EXPT STN, VICKSBURG, MS 39180 USA. NR 23 TC 13 Z9 14 U1 0 U2 7 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0277-5212 J9 WETLANDS JI Wetlands PD SEP PY 1996 VL 16 IS 3 BP 358 EP 365 PG 8 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA VK499 UT WOS:A1996VK49900011 ER PT J AU Wilber, DH Tighe, RE ONeil, LJ AF Wilber, DH Tighe, RE ONeil, LJ TI Associations between changes in agriculture and hydrology in the Cache River Basin, Arkansas, USA SO WETLANDS LA English DT Article DE forested wetlands; hydrology; ground water; land use; agriculture; Cache River; Arkansas AB Impacts to the hydrology of the Cache River, a major river system in the Mississippi Alluvial Valley, were assessed by integrating hydrologic analyses with a review of historical land use changes. Extreme low flows have become more frequent in recent years, coincident with a dramatic increase in rice farming in the basin and its associated irrigation. Annual drawdowns in the alluvial aquifer were positively correlated with the annual area of rice crops. There is no evidence that a change in climatic conditions accounts for the increase in extreme low flow frequency. In fact, multiple regression analyses indicate the relationship between climate and flow is weakest in more recent decades when extreme low flows were more prevalent. Low flows in the summer (when rice irrigation occurs) were least associated with climate in most recent decades. Average monthly flows for August and September have increased, which is also an impact consistent with rice agriculture practices. Water is drained from rice fields to surface-water drainages at the end of the summer and may eventually reach the Cache River, thus increasing late summer flows. The timing and nature of changes in agricultural practices within the Cache River basin suggest agricultural impacts have contributed to the observed changes in hydrology. RP Wilber, DH (reprint author), USA,ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 26 TC 16 Z9 16 U1 1 U2 10 PU SOC WETLAND SCIENTISTS PI LAWRENCE PA 810 E TENTH ST, P O BOX 1897, LAWRENCE, KS 66044 SN 0277-5212 J9 WETLANDS JI Wetlands PD SEP PY 1996 VL 16 IS 3 BP 366 EP 378 PG 13 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA VK499 UT WOS:A1996VK49900012 ER PT J AU Long, KS Nestler, JM AF Long, KS Nestler, JM TI Hydroperiod changes as clues to impacts on Cache River Riparian Wetlands SO WETLANDS LA English DT Article DE impact assessment; environmental impact; Cache River; White River; streamflow; hydrology; daily values; harmonic analysis; nonlinear regression models; time-scale analysis; root-mean-square error ID CUMULATIVE IMPACTS; GROUNDWATER; WATER; BALQUHIDDER; HYDROLOGY; BASIN; SPAIN AB A hydrologic analysis of historic stream gage data collected on the Cache River at Patterson, Arkansas is presented as a basis for impact analysis of riverine wetlands. Subtle, long-term changes in hydroperiod that could collectively have major impacts on wetland functions are quantified. Harmonic analysis, time-scale analysis, and conventional methods of hydrologic analysis of gage data at decade intervals are employed. These various techniques indicate a steady decline in the magnitude and predictability of the base flow during low flow periods, beginning with the 1920s and becoming increasingly more pronounced into the 1980s. Complementary information suggests that hydroperiod alterations can be associated with increased ground-water pumping and associated land use changes in the Cache River basin. Hydrologic indices wer developed that range from intuitively simple but generally insensitive indices based on means, medians, ranges, and discharge-duration curves to indices that are based on methods sensitive to subtle changes in hydrologic patterns. One set of sensitive indices generated by harmonic analysis is relatively simple to obtain and useful to explore changes in the pattern of discharges or stages in wetlands. The timescale analysis can be employed to provide a relatively high resolution quantification of changes in hydrology that can be related to long-term changes in land- or water-use patterns. The hydrologic methods presented in these analyses are simple enough for routine application (when adequate data are available) but sufficiently sophisticated to identify subtle changes in hydroperiod associated with impacts and passage of time. Changes in hydroperiod identified by these methods may have the potential to explain changes in biotic communities or wetland structure as part of comprehensive wetland studies. RP Long, KS (reprint author), USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 36 TC 9 Z9 9 U1 0 U2 5 PU SOC WETLAND SCIENTISTS PI LAWRENCE PA 810 E TENTH ST, P O BOX 1897, LAWRENCE, KS 66044 SN 0277-5212 J9 WETLANDS JI Wetlands PD SEP PY 1996 VL 16 IS 3 BP 379 EP 396 PG 18 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA VK499 UT WOS:A1996VK49900013 ER PT J AU Lee, YH Clark, MM AF Lee, YH Clark, MM TI A numerical model for flux decline during crossflow ultrafiltration. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV ILLINOIS,DEPT CIVIL ENGN,ENVIRONM SCI & ENGN PROGRAM,URBANA,IL 61801. USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61826. RI Clark, Mark /E-3509-2010 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1996 VL 212 BP 25 EP ENVR PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA VA915 UT WOS:A1996VA91501652 ER PT J AU Engberts, JBFN Famini, GR Perjessy, A Wilson, LY AF Engberts, JBFN Famini, GR Perjessy, A Wilson, LY TI Solvent effects on C=O stretching frequencies of 1-substituted 2-pyrrolidinones and related compounds. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV GRONINGEN,DEPT ORGAN & MOLEC INORGAN CHEM,GRONINGEN,NETHERLANDS. USA,EDGEWOOD RES,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. COMENIUS UNIV BRATISLAVA,FAC NAT SCI,DEPT ORGAN CHEM,BRATISLAVA,SLOVAKIA. LA SIERRA UNIV,DEPT CHEM,RIVERSIDE,CA 92515. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1996 VL 212 BP 77 EP COMP PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA VA915 UT WOS:A1996VA91501463 ER PT J AU Sanov, A Bieler, CR Capellos, C Reisler, H AF Sanov, A Bieler, CR Capellos, C Reisler, H TI State-resolved molecular beam studies of collisional dissociation of highly excited molecules SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV SO CALIF,DEPT CHEM,LOS ANGELES,CA 90089. USA,ARDEC,AMSTA AR AEE,DOVER,NJ 07801. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1996 VL 212 BP 109 EP PHYS PN 2 PG 2 WC Chemistry, Multidisciplinary SC Chemistry GA VB009 UT WOS:A1996VB00900613 ER PT J AU Meagher, NE Anderson, WR Ilincic, N Seshadri, K Vanderhoff, JA AF Meagher, NE Anderson, WR Ilincic, N Seshadri, K Vanderhoff, JA TI Chemical mechanisms for the dark zones of double base and nitramine gun propellants. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,BALLIST RES LAB,ABERDEEN PROVING GROUND,MD 21005. UNIV CALIF SAN DIEGO,DEPT APPL MECH & ENGN SCI,LA JOLLA,CA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1996 VL 212 BP 129 EP COMP PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA VA915 UT WOS:A1996VA91501514 ER PT J AU McPherson, JC Smith, TM Stroebel, GG Stevens, JM McPherson, JC AF McPherson, JC Smith, TM Stroebel, GG Stevens, JM McPherson, JC TI Triton WR-1339, poloxamer 188 and poloxamer 407 provides equal protection to red cells in the mechanical fragility test. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 MED COLL GEORGIA,AUGUSTA,GA 30912. AUGUSTA COLL,AUGUSTA,GA 30904. EISENHOWER ARMY MED CTR,FT GORDON,GA 30905. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1996 VL 212 BP 131 EP MEDI PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA VA915 UT WOS:A1996VA91502689 ER PT J AU Abdeldayem, HA Frazier, DO Penn, BG Witherow, WK Banks, C Shields, AD Hicks, RM AF Abdeldayem, HA Frazier, DO Penn, BG Witherow, WK Banks, C Shields, AD Hicks, RM TI Nonlinear optical properties of vapor deposited metal-free phthalocyanine thin films SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 NASA,GEORGE C MARSHALL SPACE FLIGHT CTR,SPACE SCI LAB,HUNTSVILLE,AL 35812. USA,MISSILE COMMAND,CTR RES DEV & ENGN,REDSTONE ARSENAL,AL 35898. UNIV SPACE RES ASSOC,COLUMBIA,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1996 VL 212 BP 139 EP ORGN PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA VB009 UT WOS:A1996VB00900139 ER PT J AU Wright, DJ Smith, TM Stroebel, GG McPherson, JC Runner, RR McPherson, JC AF Wright, DJ Smith, TM Stroebel, GG McPherson, JC Runner, RR McPherson, JC TI Poloxamer 407 binding to and protection of red blood cells. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 AUGUSTA COLL,AUGUSTA,GA 30904. EISENHOWER ARMY MED CTR,FT GORDON,GA 30905. MED COLL GEORGIA,AUGUSTA,GA 30912. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1996 VL 212 BP 141 EP CHED PN 1 PG 2 WC Chemistry, Multidisciplinary SC Chemistry GA VA915 UT WOS:A1996VA91500809 ER PT J AU Litvin, AL Bliznyuk, VN Tsukruk, VV Valiyaveettil, S Kaplan, DL AF Litvin, AL Bliznyuk, VN Tsukruk, VV Valiyaveettil, S Kaplan, DL TI Supramolecular hydrogen-bonded polymer networks SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. WESTERN MICHIGAN UNIV,KALAMAZOO,MI 49008. MAX PLANCK INST POLYMER RES,D-55128 MAINZ,GERMANY. RI Valiyaveettil, Suresh/D-4848-2009 OI Valiyaveettil, Suresh/0000-0001-6990-660X NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1996 VL 212 BP 273 EP POLY PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA VB009 UT WOS:A1996VB00901122 ER PT J AU Adams, JW Larson, SL Weiss, CA AF Adams, JW Larson, SL Weiss, CA TI MD simulations of nitroaromatic fixation onto clay minerals. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,ENGINEER WATERWAYS EXPT STN,STRUCT LAB,VICKSBURG,MS 39180. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1996 VL 212 BP 291 EP PHYS PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA VB009 UT WOS:A1996VB00900792 ER PT J AU Moriarty, RM Condeiu, C Tuladhar, SM Lenz, D Brimfield, A AF Moriarty, RM Condeiu, C Tuladhar, SM Lenz, D Brimfield, A TI Phosphorus haptens for catalytic antibody production: Bifunctional catalysis using rigid systems and bait and switch strategy SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV ILLINOIS,DEPT CHEM,CHICAGO,IL 60607. STEROIDS LTD,CHICAGO,IL 60612. USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1996 VL 212 BP 300 EP ORGN PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA VB009 UT WOS:A1996VB00900299 ER PT J AU Munavalli, S BashirHashemi, A Rossman, DI Rohrbaugh, DK Berg, FJ Durst, HD AF Munavalli, S BashirHashemi, A Rossman, DI Rohrbaugh, DK Berg, FJ Durst, HD TI Anomalous reaction of bridgehead esters with DIBAL. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 GEOCENTERS INC,FT WASHINGTON,MD 20774. GEOCENTERS INC,LAKE HOPATCONG,NJ 07849. USA,ERDEC,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1996 VL 212 BP 333 EP ORGN PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA VB009 UT WOS:A1996VB00900332 ER PT J AU Allan, JM Gregory, RV Pearce, FJ Shalaby, SW AF Allan, JM Gregory, RV Pearce, FJ Shalaby, SW TI Formation of polypyrrole surface and interaction of substrate and leachables with fibroblasts. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 CLEMSON UNIV,CLEMSON,SC 29634. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. POLY MED INC,CTR APPL TECHNOL,PENDLETON,SC 29670. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1996 VL 212 BP 334 EP POLY PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA VB009 UT WOS:A1996VB00901183 ER PT J AU Duddu, R Damavarapu, R AF Duddu, R Damavarapu, R TI Nitronium ion mediated functionalization of adamantane and its derivatives SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 GEOCENTERS INC,LAKE HOPATCONG,NJ 07849. USA,CTR RES DEV & ENGN,PICATINNY ARSENAL,NJ 07806. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1996 VL 212 BP 352 EP ORGN PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA VB009 UT WOS:A1996VB00900351 ER PT J AU Schroeder, MA Fifer, RA Miller, MS PesceRodriguez, RA Selawski, CJ Singh, G Widder, JM AF Schroeder, MA Fifer, RA Miller, MS PesceRodriguez, RA Selawski, CJ Singh, G Widder, JM TI Condensed-phase processes in combustion of solid gun propellants SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1996 VL 212 BP 380 EP ORGN PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA VB009 UT WOS:A1996VB00900379 ER PT J AU Iwamoto, LM Wilson, VL Lavallee, SL Fujiwara, N Ayau, EL Nakamura, KT AF Iwamoto, LM Wilson, VL Lavallee, SL Fujiwara, N Ayau, EL Nakamura, KT TI Tachyphylaxis to furosemide in isolated airways of guinea pigs SO LIFE SCIENCES LA English DT Article DE airway smooth muscle; newborn; bronchodilators; desensitization; Na-K-Cl cotransport ID BETA-ADRENERGIC RECEPTORS; VASCULAR SMOOTH-MUSCLE; INHALED FUROSEMIDE; INDUCED BRONCHOCONSTRICTION; BRONCHOPULMONARY DYSPLASIA; ADRENOCEPTOR AGONISTS; LOOP DIURETICS; ION-TRANSPORT; IN-VITRO; DESENSITIZATION AB This in vitro study was conducted to determine whether tachyphylaxis of guinea pig airway to furosemide occurs under conditions that produce tachyphylaxis to the beta(2)-adrenoceptor agonist, salbutamol. Isometric tension was measured in tracheal rings bathed in HEPES buffer from 4-6 d newborn guinea pigs of either sex, and 6 wk old males. Paired rings were first incubated with furosemide, 30 or 300 mu M, or control for 60 min, washed, then constricted with 3 mu M acetylcholine. At stable contraction, relaxation to furosemide (30 mu M - 1 mM) was measured. For comparison, similar experiments were performed with 10 mu M salbutamol incubation for 30 min. Rb-86 uptake, a marker for K+ transport and Na-K-Cl cotransport activity, was also measured in these airway segments. Pre-exposure to these airway relaxants did not affect contractile force generation by acetylcholine. Tracheal desensitization to both salbutamol and furosemide was observed. Partial recovery of furosemide induced relaxation was seen one hour after desensitization. Pre-exposure to 300 mu M furosemide did not inhibit the decrease in Rb-86 uptake normally observed with furosemide. In summary, we found that: 1) tachyphylaxis of guinea pig airway relaxation occurred with both salbutamol and furosemide under similar experimental conditions; however 2) inhibition of Rb-86 uptake by furosemide was not affected by prior exposure. Taken together, these results suggest that furosemide induced airway relaxation could be affected by repeated or prolonged exposure, but this response may not be associated with changes in furosemide-sensitive Na-K-Cl cotransporter activity. C1 KAPIOLANI MED CTR WOMEN & CHILDREN,DEPT PEDIAT,HONOLULU,HI 96826. JOHN A BURNS SCH MED,HONOLULU,HI 96826. TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. FU NHLBI NIH HHS [HL-45220] NR 35 TC 7 Z9 7 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0024-3205 J9 LIFE SCI JI Life Sci. PD AUG 23 PY 1996 VL 59 IS 13 BP 1015 EP 1024 DI 10.1016/0024-3205(96)00416-X PG 10 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA VD718 UT WOS:A1996VD71800001 PM 8809220 ER PT J AU deNamor, AFD Ng, JCY Tanco, MAL Salomon, M AF deNamor, AFD Ng, JCY Tanco, MAL Salomon, M TI Thermodynamics of lithium-crown ether (12-crown-4 and 1-benzyl-1-aza-12-crown-4) interactions in acetonitrile and propylene carbonate. The anion effect on the coordination process SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID ALKALI-METAL; CORONAND ELECTROLYTES; POLYDENTATE LIGANDS; ION-PAIRS; COMPLEXES; MICROCALORIMETERS; CONDUCTANCE; COUNTERION; STABILITY; CHEMISTRY AB Titration microcalorimetry in nonaqueous media (acetonitrile and propylene carbonate) has been used for the determination of stability constants (log K-s) and enthalpies of complexation of lithium and crown ethers (12-crown-4 and 1-benzyl-1-aza-12-crown-4 at 298.15 K. To ensure that the data are referred exclusively to the complexation process, salts containing highly polarizable anions (hexafluoroasenate, tetrafluoroborate, trifluoromethanesulfonate, and perchlorate) are used as sources for lithium. From stability constants and standard enthalpies, standard Gibbs energies and standard entropies are calculated. In propylene carbonate, a correlation is found between the stability of the lithium crown complex and the increase in conductance of the complexed relative to the free cation. Eight new lithium coronand salts of 12-crown-4 and 1-benzyl-1-aza-12-crown-4 were isolated. Standard enthalpies of these salts and crown ethers in acetonitrile and propylene carbonate at 298.15 K measured calorimetrically are used to explain (i) the higher molar ionic conductivities, observed for lithium coronand relative to lithium electrolytes, and (ii) the effect of the solution properties of ligand, free, and complexed cation in the binding of these ligands with lithium in these solvents. Enthalpies of coordination first reported show the anion effect in the process involving reactants and product in their pure physical state. The strength of cation-anion interaction follows the sequence ClO4- > CF3SO3- > AsF6- > BF4-. C1 USA,ARL,POWER SOURCES DIV,FT MONMOUTH,NJ 07703. RP deNamor, AFD (reprint author), UNIV SURREY,DEPT CHEM,LAB THERMOCHEM,GUILDFORD GU2 5XH,SURREY,ENGLAND. NR 28 TC 30 Z9 30 U1 0 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD AUG 22 PY 1996 VL 100 IS 34 BP 14485 EP 14491 PG 7 WC Chemistry, Physical SC Chemistry GA VD991 UT WOS:A1996VD99100031 ER PT J AU Jones, DL Landry, FJ AF Jones, DL Landry, FJ TI Cost savings and prescribing protocols for nonsteroidal anti-inflammatory drugs - Reply SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter RP Jones, DL (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD AUG 21 PY 1996 VL 276 IS 7 BP 526 EP 526 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA VC101 UT WOS:A1996VC10100018 ER PT J AU Koenig, ML Yourick, DL Meyerhoff, JL AF Koenig, ML Yourick, DL Meyerhoff, JL TI Thyrotropin-releasing hormone (TRH) attenuates glutamate-stimulated increases in calcium in primary neuronal cultures SO BRAIN RESEARCH LA English DT Article DE thyrotropin-releasing hormone; calcium; glutamate; indo-1; imaging; anticonvulsant ID AMYGDALOID-KINDLED RATS; SPINAL-CORD; DEPRESSANT ACTION; BRAIN-STEM; ANALOG; RECEPTORS; DN-1417; MOTONEURONS; MODULATION; ELEVATION AB Thyrotropin-releasing hormone (TRH) has been found to be widely distributed in the mammalian central nervous system. Further, the concentration of the tripeptide increases following seizure activity, and TRH is known to have anticonvulsant effects. We have investigated the possibility that the anticonvulsant activity of TRH may be due, at least in part, to an attenuation of the glutamate-stimulated increases in intraneuronal Ca2+ ([Ca](i)) that occur with epileptic activity. We find that the tripeptide does not itself excite neurons and that it is able to significantly reduce glutamate-stimulated increases in [Ca](i) in cultured neurons derived from fetal rat forebrain. Increases in the concentration of TRH following seizure activity may represent an endogenous homeostatic mechanism for reducing glutamate-induced elevations in intraneuronal Ca2+. RP Koenig, ML (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT NEUROCHEM NEUROENDOCR,DIV NS,WASHINGTON,DC 20307, USA. NR 44 TC 28 Z9 28 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 J9 BRAIN RES JI Brain Res. PD AUG 19 PY 1996 VL 730 IS 1-2 BP 143 EP 149 PG 7 WC Neurosciences SC Neurosciences & Neurology GA VH291 UT WOS:A1996VH29100016 PM 8883898 ER PT J AU Weaver, SC Salas, R RicoHesse, R Ludwig, GV Oberste, MS Boshell, J Tesh, RB AF Weaver, SC Salas, R RicoHesse, R Ludwig, GV Oberste, MS Boshell, J Tesh, RB TI Re-emergence of epidemic Venezuelan equine encephalomyelitis in South America SO LANCET LA English DT Article ID ENCEPHALITIS COMPLEX; VIRUSES; IDENTIFICATION; ALPHAVIRUSES; ANTIBODY; VACCINE AB Background Venezuelan equine encephalomyelitis (VEE) virus has caused periodic epidemics among human beings and equines in Latin America from the 1920s to the early 1970s. The first major outbreak since 1973 occurred in Venezuela and Colombia during 1995, and involved an estimated 75 000 to 100 000 people. We report an and virological investigation of this epidemic. Methods Virus isolates were made in cell culture from human serum, human throat swabs, and brain tissue from aborted and stillborn human fetuses, as well as from horse brain tissue and pooled mosquito collections. Human sera were also tested for VEE-specific antibodies. The serotypes of VEE isolates were identified by antigen assays, and viruses were characterised genetically by sequencing PCR products generated from the E3 and E2 genes. Phylogenetic analyses were done to determine evolutionary relations with respect to previous epidemic/epizootic and enzootic VEE virus isolates. Mosquito collections were made to identify possible vectors, and clinical findings were determined by direct observation of patients visiting hospitals and clinics in affected regions, and by inspecting patient records. Equine vaccination and vector control were used in an attempt to halt the spread of the outbreak. Findings Most affected people had an acute, self-limited febrile illness of 3 to 4 days duration. However, convulsions were often seen in children, and abortions and fetal deaths occurred in pregnant women infected with VEE virus. Antigenic characterisation of 12 virus isolates spanning the temporal and spatial range of the outbreak indicated that all are VEE serotype IC. Phylogenetic analysis revealed that all of the 1995 viruses were closely related to serotype IC viruses isolated during a large VEE outbreak that occurred in the same regions of Colombia and Venezuela from 1962-1964. A 1983 mosquito isolate from north central Venezuela was also closely related to the 1995 isolates. Interpretation This outbreak was remarkably similar to one that occurred in same regions of Venezuela and Colombia during 1962-1964. Symptoms of infected patients, estimated mortality rates, meteorological conditions preceding the epidemic, and seasonal patterns of transmission were all very similar to those reported in the previous outbreak. In addition, viruses isolated during 1995 were antigenically and genetically nearly identifical to those obtained during 1962-1964. These findings suggest that the epidemic resulted from the re-emergence of an epizootic serotype IC VEE virus. Identification of a similar virus isolate in mosquitoes in Venezuela in 1983, 10 years after epidemic/epizootic VEE activity ceased, raises the possibility of a serotype IC enzootic transmission cycle in northern Venezuela. C1 UNIV TEXAS,MED BRANCH,DEPT PATHOL,GALVESTON,TX 77555. INST NACL HIGIENE RAFAEL RANGEL,CARACAS,VENEZUELA. YALE UNIV,SCH MED,DEPT EPIDEMIOL & PUBL HLTH,YALE ARBOVIRUS RES UNIT,NEW HAVEN,CT 06510. USA,MED RES INST INFECT DIS,DIV VIROL,FT DETRICK,MD 21702. INST NACL SALUD,BOGOTA,COLOMBIA. RP Weaver, SC (reprint author), UNIV TEXAS,MED BRANCH,CTR TROP DIS,GALVESTON,TX 77555, USA. RI Rico-Hesse, Rebeca/C-5294-2011; Weaver, Scott/D-6490-2011 OI Rico-Hesse, Rebeca/0000-0001-6216-1000; FU NIAID NIH HHS [AI 39508, AI 10894, AI 33983] NR 26 TC 167 Z9 172 U1 0 U2 3 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD AUG 17 PY 1996 VL 348 IS 9025 BP 436 EP 440 DI 10.1016/S0140-6736(96)02275-1 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA VC673 UT WOS:A1996VC67300011 PM 8709783 ER PT J AU Murphy, GP Barren, RJ Erickson, SJ Bowes, VA Wolfert, RL Bartsch, G Klocker, H Pointner, J Reissigl, A McLeod, DG Douglas, T Morgan, T Kenny, GM Ragde, H Boynton, AL Holmes, EH AF Murphy, GP Barren, RJ Erickson, SJ Bowes, VA Wolfert, RL Bartsch, G Klocker, H Pointner, J Reissigl, A McLeod, DG Douglas, T Morgan, T Kenny, GM Ragde, H Boynton, AL Holmes, EH TI Evaluation and comparison of two new prostate carcinoma markers - Free-prostate specific antigen and prostate specific membrane antigen SO CANCER LA English DT Article DE prostate specific antigen; free-prostate specific antigen; prostate specific membrane antigen ID CANCER PATIENTS; SERUM CONCENTRATIONS; SCREENING-TESTS; COMPLEX; ASSAY; PSA; ALPHA-1-ANTICHYMOTRYPSIN; MEN AB BACKGROUND. Two new prostate cancer markers; free-prostate specific antigen (f-PSA) and prostate specific membrane antigen (PSMA) were recently introduced. This report summarizes a prospective two-year multicenter test of their diagnostic or prognostic capabilities. Total PSA was also measured. METHODS. There were four clinical groups studied: (1) 226 individuals from a screening project undergoing ultrasound and biopsy evaluation had markers obtained: (2) 68 patients suspected of having prostate cancer and undergoing 2 or more biopsies had the markers obtained on multiple occasions: (3) 100 patients undergoing radical prostatectomy had markers obtained pre- and post-operatively: and (4) 31 patients with metastatic prostate cancer each had multiple samples for marker assay obtained over a 2-year period. In all, 465 patients had one or more samples obtained and studied. RESULTS. Free-PSA affords little additional diagnostic advantage compared with total PSA in the screening population. The reciever operating characteristic curves for diagnostic accuracy were ranked: (1) PSA density; (2) total PSA; (3) f-PSA; and (4) PSMA. PSMA showed the best correlation with stage of the primary tumor in the screened group. In the multiple negative biopsy group, f-PSA varied from 12 to 21%. PSMA values were evaluated in all histologic categories. PSA density was greater than or equal to 0.15 in all categories. In the prostatectomy cases PSA values postoperatively were quite low in Stage II; f-PSA was of no value. Later, f-PSA was increased In association with elevated total PSA values. Mean PSMA values were above normal in all postoperative time periods except in Stage III patients at 6 months to 1 year postoperatively. PSA densities were all greater than or equal to 0.15. In patients with metastatic carcinoma, elevated PSMA values correlated best with a poor prognosis (clinical progression), as has been described. CONCLUSIONS. These data suggest that f-PSA values do not provide additional diagnostic benefit compared with total PSA in screening populations, in the presence of suspected cancer, postprostatectomy, or in metastatic disease. PSMA is of prognostic significance, especially in the presence of metastatic disease, and correlates well with the stage of disease in cancers detected in a screened population. (C) 1996 American Cancer Society. C1 HYBRITECH INC, DIV DIAGNOST RES & DEV, SAN DIEGO, CA USA. UNIV INNSBRUCK, DEPT UROL, A-6020 INNSBRUCK, AUSTRIA. WALTER REED ARMY MED CTR, UROL SERV, WASHINGTON, DC 20307 USA. UNIFORMED SERV UNIV HLTH SCI, BETHESDA, MD 20814 USA. CTR PROSTATE DIS RES, WASHINGTON, DC USA. RP Murphy, GP (reprint author), NORTHWEST HOSP, PACIFIC NW CANC FDN, CANC RES DIV, 120 NORTHGATE PLAZA, SUITE 205, SEATTLE, WA 98125 USA. NR 22 TC 49 Z9 50 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0008-543X EI 1097-0142 J9 CANCER-AM CANCER SOC JI Cancer PD AUG 15 PY 1996 VL 78 IS 4 BP 809 EP 818 DI 10.1002/(SICI)1097-0142(19960815)78:4<809::AID-CNCR18>3.0.CO;2-Z PG 10 WC Oncology SC Oncology GA VA437 UT WOS:A1996VA43700018 PM 8756376 ER PT J AU Hopkins, MA AF Hopkins, MA TI On the mesoscale interaction of lead ice and floes SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID SEA-ICE; RIDGE SAILS; MODEL AB The plasticity of the Arctic ice pack depends on its granular nature, in particular on the size and distribution of areas of thin ice and open water surrounding multiyear ice flees. The paper begins with construction of a mesoscale (10-100 km) granular model of the central Arctic ice pack. The mesoscale model is based on a dynamic particle simulation in which individual multiyear ice floes and surrounding parcels of first-year ice are explicitly modeled as discrete, convex polygons in a two-dimensional domain. Deformation of the domain produces areas of localized failure and areas of open water. The areas of localized failure are modeled as pressure ridging events using the results of numerical experiments performed with a computer simulation of the ridging process. The paper focuses on the results of numerical experiments performed with the mesoscale model. In the experiments the model ice pack is biaxially deformed at constant strain rates. The principal strain rates are varied to create deformation states ranging from pure shear to uniform compression. The results define the shape and magnitude of the plastic yield surface, the strain rate vectors associated with points on the yield surface, the partition of energy dissipation between ridging and in-plane sliding, and the changes in the ice thickness distribution associated with various deformation states. RP Hopkins, MA (reprint author), USA,COLD REG RES & ENGN LAB,CORPS ENGINEERS,72 LYME RD,HANOVER,NH 03755, USA. NR 16 TC 35 Z9 41 U1 0 U2 2 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD AUG 15 PY 1996 VL 101 IS C8 BP 18315 EP 18326 DI 10.1029/96JC01689 PG 12 WC Oceanography SC Oceanography GA VC707 UT WOS:A1996VC70700018 ER PT J AU Perovich, DK Gow, AJ AF Perovich, DK Gow, AJ TI A quantitative description of sea ice inclusions SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID BRINE DRAINAGE CHANNELS; PHYSICAL-PROPERTIES; OPTICAL-PROPERTIES; LIGHT-REFLECTION; MICROWAVE; MODEL; MICROSTRUCTURE; SCATTERING; MEDIA AB Structurally, sea ice consists of an ice matrix with inclusions of brine and air. A quantitative description of the size of these inclusions is critical for both interpreting and modeling the electromagnetic properties of sea ice. Photomicrographs of ice thin sections were analyzed using a personal computer-based image-processing system to determine the number of inclusions, the inclusion size distributions, and statistics for brine pockets in young ice and first-year ice and for air bubbles in a multiyear hummock. Inclusions ranging in size from thousandths of square millimeters to a few square millimeters were measured. In all cases a two-parameter lognormal distribution fits the cumulative inclusion size distributions well (correlation coefficient greater than 0.99). This includes brine pockets in both granular and columnar ice and a range of brine volumes from 2% to 40%. As ice warms, and its brine volume increases, the size distribution shifts toward larger brine pockets. This increase in brine pocket size is particularly pronounced for brine volumes greater than 10% as individual brine pockets coalesce. Air bubbles are much larger than brine pockets, with mean major axis lengths of the order of millimeters for air bubbles and tenths of a millimeter for brine pockets. Observations of inclusion shape factors indicate that, in general, brine pockets are more elongated than air bubbles. RP Perovich, DK (reprint author), USA,COLD REG RES & ENGN LAB,CORPS ENGINEERS,72 LYME RD,HANOVER,NH 03755, USA. NR 55 TC 54 Z9 57 U1 0 U2 10 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD AUG 15 PY 1996 VL 101 IS C8 BP 18327 EP 18343 DI 10.1029/96JC01688 PG 17 WC Oceanography SC Oceanography GA VC707 UT WOS:A1996VC70700019 ER PT J AU Chen, G Nachman, P Pinnick, RG Hill, SC Chang, RK AF Chen, G Nachman, P Pinnick, RG Hill, SC Chang, RK TI Conditional-firing aerosol-fluorescence spectrum analyzer for individual airborne particles with pulsed 266-nm laser excitation SO OPTICS LETTERS LA English DT Article ID BIOLOGICAL PARTICLES AB We report the operation of an aerosol-fluorescence spectrum analyzer capable of selectively measuring the fluorescence spectra of single micrometer-sized aerosol particles as they flow through the instrument. As the particle first traverses a cw 488-nm probe laser beam, the total fluorescence and elastic scattering are measured with photomultipliers. When the photomultiplier output levels meet preset logic conditions, a UV laser (at 266 nm) is fired and the particle fluorescence spectrum is recorded. Fluorescence spectra of biological airborne particles are presented. The ability of the analyzer to capture the fluorescence spectrum of one type of particle while ignoring others, based on the particle characteristics, is also demonstrated. (C) 1996 Optical Society of America C1 YALE UNIV,CTR LASER DIAGNOST,NEW HAVEN,CT 06520. USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP Chen, G (reprint author), YALE UNIV,DEPT APPL PHYS,NEW HAVEN,CT 06520, USA. NR 8 TC 42 Z9 44 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD AUG 15 PY 1996 VL 21 IS 16 BP 1307 EP 1309 DI 10.1364/OL.21.001307 PG 3 WC Optics SC Optics GA VA997 UT WOS:A1996VA99700035 PM 19876334 ER PT J AU Fischell, TA Carter, AJ Laird, JR AF Fischell, TA Carter, AJ Laird, JR TI The beta-particle-emitting radioisotope stent (isostent): Animal studies and planned clinical trials SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Article; Proceedings Paper CT Eighth Annual Transcatheter Cardiovascular Therapeutics (TCT) Symposium CY FEB 28-MAR 03, 1996 CL WASHINGTON, DC ID MUSCLE CELL-PROLIFERATION AB Radiation delivered by intravascular stent is an appealing approach to prevent neointimal hyperplasia, since it nonselectively kills dividing cells. In particular, beta-particle-emitting radioisotope stents may prove to be an ideal means of local irradiation in that 95% of the dose is delivered within 4 mm of the stent edge and the dose drops off rapidly to <1/1,000 of the original dose at 5 months postimplantation. In the in vitro smooth muscle cell model, one can observe a zone of growth inhibition around radioactive stent wires that averages about 6 mm at very-low-activity levels (0.006 mu Ci/cm of wire). In vivo studies in animal models, including porcine iliac and coronary arteries and rabbit iliac arteries, have shown the effectiveness of radioisotope stents in inhibiting neointimal proliferation. Proliferating endothelial cells appear to be relatively radioresistant. A computer model was employed to look at the radiation dose delivered as a function of distance from the scent. With very-low-activity stents, presumably, DNA of the smooth muscle cells is damaged as they migrate through the ''electron fence'' on the way to the neolumen, diminishing the population of myofibroblasts and reducing hyperplasia. Catheter-based radiation therapies may disable these cells before they migrate, although such an approach may not inhibit early recoil or late contraction. Based on the characteristics of beta emissions (i.e., rapid drop-off, minimal leaching), radioisotope stents containing phosphorus-32 appear to be safe. A randomized triple-blind clinical trial is planned to assess restenosis at 6 months in native coronary arteries treated with radioisotope stents. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP Fischell, TA (reprint author), HEART INST BORGESS,MED CTR,1722 SHAFFER ST,KALAMAZOO,MI 49001, USA. NR 5 TC 36 Z9 41 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD AUG 14 PY 1996 VL 78 SU 3A BP 45 EP 50 DI 10.1016/S0002-9149(96)00489-4 PG 6 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA WK910 UT WOS:A1996WK91000010 PM 8751847 ER PT J AU Moore, DW Farrar, JD AF Moore, DW Farrar, JD TI Effect of growth on reproduction in the freshwater amphipod, Hyalella azteca (Saussure) SO HYDROBIOLOGIA LA English DT Article DE life-history; food ration; interpretive guidance; sublethal; chronic ID CHRONIC TOXICITY; CADMIUM; HORMESIS; COPPER; ACCUMULATION; GAMMARUS; DAPHNIA; ZINC; SIZE; LAKE AB A gradient in H. azteca growth was created by reducing food ration. Tests were initiated with neonates (less than or equal to 48 h old) and the effects of an altered food ration on survival and growth were examined after 10 and 49 days. Growth rates decreased significantly with reduced food ration (10 day growth rates ranged from 1.2 mu g d(-1) in the highest feeding regime to 0.5 mu g d(-1) in lowest feeding regime). Survival after 10 days was not affected by ration, ranging from 86 to 96%. A growth rate of 1.2 mu g d(-1) at day 10 resulted in mean dry weight (1.0 mg), survival (62%) and reproduction (9.3 neonates/female) at day 49 similar to reported values for this species. Growth rates less than or equal to 0.9 mu g d(-1) at day 10 corresponded to significantly reduced reproduction at day 49 (i.e., <1 neonate per female). Time to the onset of amplexus increased with decreasing ration suggesting reduced ration may have delayed reproduction. RP Moore, DW (reprint author), USA,CORPS ENGINEERS,WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 44 TC 16 Z9 16 U1 0 U2 5 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0018-8158 J9 HYDROBIOLOGIA JI Hydrobiologia PD AUG 9 PY 1996 VL 328 IS 2 BP 127 EP 134 DI 10.1007/BF00018709 PG 8 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA VG104 UT WOS:A1996VG10400003 ER PT J AU Vezzoli, GC Chen, MF Burke, T Rosen, C AF Vezzoli, GC Chen, MF Burke, T Rosen, C TI Indication of confirmation of transition and formation boundary from ordered to disordered flux vortex chain state in high-T-c superconductors Y1Ba2Cu3O7-delta and Bi2Sr2Ca2Cu3O10 and new low-field data delineating magnetic transition in Gd1Ba2(Fe0.02Cu0.98)(3)O-7-delta SO PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES LA English DT Article ID II SUPERCONDUCTORS; LATTICE; TEMPERATURE; FREQUENCY; YBA2CU3O7; FILMS C1 BROOKLINE DEPT EDUC, BROOKLINE, MA 02146 USA. USA, RES LAB, MARYLAND MAT DIRECTORATE, ABERDEEN PROVING GROUND, MD 21005 USA. USA, RES LAB, ELECT POWER SOURCES BRANCH, FT MONMOUTH, NJ 07703 USA. THERMOMETR CORP, EDISON, NJ 08817 USA. NR 40 TC 1 Z9 1 U1 1 U2 1 PU ROYAL SOC PI LONDON PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND SN 1364-5021 EI 1471-2946 J9 P ROY SOC A-MATH PHY JI Proc. R. Soc. A-Math. Phys. Eng. Sci. PD AUG 8 PY 1996 VL 452 IS 1951 BP 1729 EP 1743 DI 10.1098/rspa.1996.0092 PG 15 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA VC819 UT WOS:A1996VC81900001 ER PT J AU Conrad, R Raizer, YP Sarzhikov, ST AF Conrad, R Raizer, YP Sarzhikov, ST TI Continuous optical discharge stabilized by gas flow in weakly focused laser beam SO AIAA JOURNAL LA English DT Article ID SUSTAINED PLASMAS; ARGON; PROPULSION; MODEL AB For the first time, an old experiment is described where a continuous optical discharge is maintained in a large, weakly focused beam of a gasdynamic CO2-laser (P = 150 kW), the discharge being stabilized by nitrogen flow at a velocity of 10 m/s opposite to the plasma propagation. This experiment, in other words, produced a large, optical plasmotron. A detailed model, developed to simulate such phenomena numerically (including the laser supported combustion wave), is described. The most important factors, two-dimensional gas flow, heat conductivity, radiation heat exchange, and refraction of the laser radiation in the plasma, are taken into account. The numerical results for the aforementioned experiment are given, the temperature and velocity fields are plotted, and the gas energy balance is analyzed. The computed gas how velocity (9 m/s) agrees well with the experimental value. For such a velocity, the numerical model shows that the plasma exists stably in a 150-kW beam at that section of the beam (a diameter of 3.2 cm) where the plasma was observed to stop in the experiment. On the basis of the developed theory (confirmed by comparison with the experiment and the numerical model), various other laser beam/plasma phenomena can be simulated; for example, the operation of a laser-plasma rocket thruster. C1 USA,MISSILE RES DEV & ENGN CTR,REDSTONE ARSENAL,AL 35653. RUSSIAN ACAD SCI,INST PROBLEMS MECH,DEPT PHYS GASDYNAM,MOSCOW 117526,RUSSIA. RI Raizer, Yuri/D-2089-2016 OI Raizer, Yuri/0000-0003-2200-8129 NR 25 TC 7 Z9 7 U1 0 U2 3 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0001-1452 J9 AIAA J JI AIAA J. PD AUG PY 1996 VL 34 IS 8 BP 1584 EP 1588 DI 10.2514/3.13275 PG 5 WC Engineering, Aerospace SC Engineering GA VA285 UT WOS:A1996VA28500006 ER PT J AU McCormick, SE Goodman, ZD Maydonovitch, CL Sjogren, MH AF McCormick, SE Goodman, ZD Maydonovitch, CL Sjogren, MH TI Evaluation of liver histology, ALT elevation, and HCV RNA titer in patients with chronic hepatitis C SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article ID POLYMERASE CHAIN-REACTION; CHRONIC ACTIVE HEPATITIS; IMMUNOLOGICAL FEATURES; INTERFERON-ALPHA; VIRUS; DISEASE; VIREMIA; INFECTION AB Objective: Hepatic histological evaluation is currently the gold standard to determine the degree of liver injury in chronic hepatitis C. It is unclear whether degree of serum ALT elevation or quantitative hepatitis C virus (HCV) RNA can predict level of histological damage, Methods: Fifty nine biopsies from 44 patients with chronic hepatitis C were reviewed, The amount of liver damage was quantified using the Histology Activity Index (HAI) and was compared with serum ALT and, in 26 biopsies, quantitative HCV RNA (branched DNA amplification, Quantiplex, Chiron), Results: A statistically significant linear relationship was noted between degree of ALT elevation and amount of liver injury based on HAI score (p < 0.05) although this relationship was not statistically strong (r(s) = 0.4900), No significant correlation was noted between serum ALT and HCV RNA titer (r(s) = 0.4044) or between quantitative HCV RNA titer and HAI score (r(s) = 0.3506), No individual component of the HAI correlated with ALT or HCV RNA, Conclusions: Although there is a correlation between serum ALT and degree of hepatic injury based on HAI score, this relationship is weak and probably of no clinical use, There is no significant correlation between HCV RNA and serum ALT or HCV RNA and degree of hepatic injury in individual patients, Hepatic histological evaluation continues to be required for clinical assessment of patients with chronic hepatitis C. C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,DEPT GASTROENTEROL,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,DIV HEPAT,WASHINGTON,DC 20306. NR 21 TC 79 Z9 83 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD AUG PY 1996 VL 91 IS 8 BP 1516 EP 1522 PG 7 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA VB469 UT WOS:A1996VB46900009 PM 8759653 ER PT J AU Parker, JM Dillard, TA Phillips, YY AF Parker, JM Dillard, TA Phillips, YY TI Arm span-height relationships in patients referred for spirometry SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Article AB Arm span has been proposed as a surrogate for standing height in the prediction of lung volumes in patients with thoracic deformities or who are unable to stand. The relationship between arm span and height has previously been reported as either a fixed ratio unaffected by age or as a regression equation in which the ratio varies as a function of age. We studied the relationship between standing height, arm span, race, sex, and age in 202 patients (ages 20 to 88 yrs) referred for screening spirometry. Multiple linear regression analysis found arm span, race, sex, and age to be predictive of standing height (r(2) = 0.8659, p < 0.0001). Subgroup analysis revealed that age was a significant factor among males of either race, but not among females of either race. Fixed arm span to height ratios were also calculated for each group and may be used to estimate standing height with reasonable accuracy except at extremes of stature. C1 WALTER REED ARMY MED CTR,DEPT PULM,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CRIT CARE MED,WASHINGTON,DC 20307. MADIGAN ARMY MED CTR,DEPT PULM & CRIT CARE MED,TACOMA,WA 98431. NR 9 TC 40 Z9 43 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 1073-449X J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PD AUG PY 1996 VL 154 IS 2 BP 533 EP 536 PG 4 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA VB858 UT WOS:A1996VB85800041 PM 8756834 ER PT J AU Jackson, MR DAddio, VJ Gillespie, DL ODonnell, SD AF Jackson, MR DAddio, VJ Gillespie, DL ODonnell, SD TI The fate of residual defects following carotid endarterectomy detected by early postoperative duplex ultrasound SO AMERICAN JOURNAL OF SURGERY LA English DT Article; Proceedings Paper CT 24th Annual Meeting of the Society-for-Clinical-Vascular-Surgery CY MAR 20-26, 1996 CL RANCHO MIRAGE, CA SP Soc Clin Vasc Surg ID ANGIOGRAPHY; RECURRENT; STENOSIS AB BACKGROUND: The purpose of this study is to evaluate the results of color-flow duplex ultrasound (CFB) soon after carotid endarterectomy (CEA) to determine the incidence of residual abnormalities and their effect on subsequent outcome and management. METHODS: We reviewed 318 consecutive CEAs performed over a 48 month-period, Of these, 206 were followed up with CFD, 195 prior to discharge and 11 at first follow-up (within 9 weeks). Patients (43) followed up with only oculoplethysmography (OPG) car those with no OPG or CFD (69) were excluded from the study, All CEAs were performed under general anesthesia with routine shunting and patch angioplasty. RESULTS: Twelve of the 206 studies (5.8%) were abnormal, Two patients with an abnormal CFD sustained perioperative stroke, both of whom had distal intimal lesions of >60% diameter stenosis by velocity criteria, Four patients had >60% stenosis and were reoperated upon to correct technical errors, The remaining 6 patients are asymptomatic, Four had residual lesions of <60% stenosis, three of which have returned to normal on subsequent CFD, Two residual lesions had >60% stenosis; one returned to normal by CFD and the other remains abnormal at 10 months, In the group of 192 normal postoperative CFD studies, there were no strokes, deaths, or redo procedures (0%, 95% confidence interval 0% to 1.54%) compared with a combined 50% rate (6 of 12) of either stroke (2 of 12) or redo procedure (4 of 12) when the postoperative CFD was abnormal (95% confidence interval 22.3% to 77.7%, P < 0.0001), During the study period the CEA stroke rate was 0.9% (3 of 318), with a combined stroke-mortality rate of 1.3% (4 of 318). CONCLUSIONS: Early postoperative CFD identified residual abnormalities in 5.8% of carotid endarterectomies despite a low overall stroke mortality rate, One half of these abnormalities resulted in stroke or required operative correction, Color-flow duplex ultrasound is useful in identifying residual abnormalities following CEA and should be considered for intraoperative use. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. RP Jackson, MR (reprint author), WALTER REED ARMY MED CTR,VASC SURG SERV,WARD 64,6825 16TH ST NW,WASHINGTON,DC 20307, USA. NR 12 TC 6 Z9 7 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0002-9610 J9 AM J SURG JI Am. J. Surg. PD AUG PY 1996 VL 172 IS 2 BP 184 EP 187 DI 10.1016/S0002-9610(96)00148-1 PG 4 WC Surgery SC Surgery GA VF026 UT WOS:A1996VF02600037 PM 8795528 ER PT J AU Kuzma, PJ Calkins, MD Kline, MD Karan, SM Matson, MD AF Kuzma, PJ Calkins, MD Kline, MD Karan, SM Matson, MD TI The anesthetic management of patients with multiple pterygium syndrome SO ANESTHESIA AND ANALGESIA LA English DT Article C1 WALTER REED ARMY MED CTR,ANESTHESIA & OPERAT SERV,DEPT ANESTHESIOL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 12 TC 8 Z9 8 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD AUG PY 1996 VL 83 IS 2 BP 430 EP 432 PG 3 WC Anesthesiology SC Anesthesiology GA UZ991 UT WOS:A1996UZ99100041 PM 8694333 ER PT J AU Stoltzfus, DP Ries, MC Watson, CB AF Stoltzfus, DP Ries, MC Watson, CB TI Critical care anesthesiology is not perioperative medicine - Response SO ANESTHESIA AND ANALGESIA LA English DT Letter C1 WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. BRIDGEPORT HOSP,DEPT ANESTHESIOL & CRIT CARE MED,BRIDGEPORT,CT 06610. RP Stoltzfus, DP (reprint author), UNIV FLORIDA,COLL MED,DEPT ANESTHESIOL,GAINESVILLE,FL 32610, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD AUG PY 1996 VL 83 IS 2 BP 435 EP 435 PG 1 WC Anesthesiology SC Anesthesiology GA UZ991 UT WOS:A1996UZ99100049 ER PT J AU Kline, MD AF Kline, MD TI After transdermal fentanyl: Acute toxic delirium or central anticholinergic syndrome? Reply SO ANESTHESIOLOGY LA English DT Letter RP Kline, MD (reprint author), WALTER REED ARMY MED CTR,ANESTHESIA PAIN SERV,690 GEORGIA AVE,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD AUG PY 1996 VL 85 IS 2 BP 437 EP 437 DI 10.1097/00000542-199608000-00037 PG 1 WC Anesthesiology SC Anesthesiology GA VB442 UT WOS:A1996VB44200038 ER PT J AU Marion, GM AF Marion, GM TI Elemental mobility through small tundra watersheds SO ARCTIC AND ALPINE RESEARCH LA English DT Article ID ALASKAN TUNDRA; ARCTIC TUNDRA; CHEMISTRY; NUTRIENT; ALUMINUM; PHOSPHORUS; NITROGEN; BALANCE; GROWTH; EXPORT AB Tundra plants and soils may constrain ecosystem response to climate change. To understand these constraints requires integrated studies of biogeochemical cycling in tundra ecosystems. This paper summarizes a 4-yr irrigation-fertilization experiment designed to evaluate elemental mobility through small tundra watersheds and examines the ''leaky ecosystem-nutrient hypothesis.'' The irrigation treatment increased elemental mobility of Fe and Mn, possibly due to reducing conditions caused by waterlogging. Ammonium and NO3 concentrations remained above background levels for four field seasons following application of a slow-release NPK fertilizer. Sharp peaks and valleys in NH4 and NO3 concentrations over the four seasons suggest slow fertilizer solubilization due to low temperatures and mixing of waters of variable composition. Fertilizer P showed limited mobility. Soil solutions were saturated with respect to gibbsite suggesting that a gibbsite-like mineral may control Al solubility in these arctic soils. Comparisons of elemental concentrations among tundra ecosystems indicate that weathering rates are highly individualistic, depending critically on soil parent material. Furthermore, tundra ecosystems are leaky with respect to nutrients, which may have ramifications well beyond the disturbance both with respect to time and space, and bears attention in assessing the future response of tundra ecosystems. RP Marion, GM (reprint author), USA, COLD REG RES & ENGN LAB, 72 LYME RD, HANOVER, NH 03755 USA. NR 40 TC 2 Z9 2 U1 0 U2 3 PU INST ARCTIC ALPINE RES PI BOULDER PA UNIV COLORADO, BOULDER, CO 80309 USA SN 0004-0851 J9 ARCTIC ALPINE RES JI Arct. Alp. Res. PD AUG PY 1996 VL 28 IS 3 BP 339 EP 345 DI 10.2307/1552113 PG 7 WC Environmental Sciences; Geography SC Environmental Sciences & Ecology; Geography GA VE605 UT WOS:A1996VE60500011 ER PT J AU Arciero, RA Scoville, CR Snyder, RJ Uhorchak, JM Taylor, DC Huggard, DJ AF Arciero, RA Scoville, CR Snyder, RJ Uhorchak, JM Taylor, DC Huggard, DJ TI Single versus two-incision arthroscopic anterior cruciate ligament reconstruction SO ARTHROSCOPY LA English DT Article DE ACL reconstruction; arthroscopic-assisted; endoscopic; two-incision ID PATELLAR TENDON; IMAGING EVALUATION; INJURIES; SEMITENDINOSUS; REPAIR; TEARS; KNEE AB The purpose of this study was to compare single (endoscopic) versus two-incision arthroscopic anterior cruciate ligament reconstruction using bone-patellar tendon-bone in a population of young athletes. All patients followed a similar postoperative rehabilitation program. The Lysholm knee score, the International Knee Documentation Committee Score, KT-1000 arthrometric measurements, Lachman tests, pivot shift tests, isokinetic and functional testing, and perioperative complications were used to compare the two techniques. Anteroposterior and lateral radiographs were also evaluated and compared. Group I comprised 51 patients who underwent two-incision arthroscopic ACL reconstruction. The average age was 19.8 years, with a range of 18 to 22. The average follow-up in this group was 31 months (range, 24 to 43 months). Group II, the endoscopic group, consisted of 31 patients with an average age of 19.4 years (range, 18 to 22), The average follow-up was 25 months (range, 24 to 31 months). There were no significant differences between the two groups using subjective, objective, and functional criteria. There did appear to be a trend toward a residual pivot glide in the endoscopic group, but this did not achieve statistical significance. Radiographic analysis demonstrated an increased incidence of screw divergence in the endoscopic group. Intraoperative complications were more common with the endoscopic method. RP Arciero, RA (reprint author), KELLER ARMY COMMUNITY HOSP,ORTHOPAED SERV,W POINT,NY 10996, USA. NR 27 TC 32 Z9 32 U1 0 U2 2 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0749-8063 J9 ARTHROSCOPY JI Arthroscopy PD AUG PY 1996 VL 12 IS 4 BP 462 EP 469 PG 8 WC Orthopedics; Surgery SC Orthopedics; Surgery GA VC876 UT WOS:A1996VC87600011 PM 8864005 ER PT J AU Albano, JP Shannon, SG Alem, NM Mason, KT AF Albano, JP Shannon, SG Alem, NM Mason, KT TI Injury risk for research subjects with spina bifida occulta in a repeated impact study: A case review SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Review AB Spina bifida occulta (SBO) occurs in 18-34% of the normal U.S. population. Recently, 16.5% of normal, asymptomatic male soldier volunteer candidates in a U.S. Army Aeromedical Research Laboratory ride motion study were excluded from the study because they had SBO at one vertebral level. Disqualifying this percentage of screened research subject candidates threatened the timely completion of the schedule-intense protocol. Although one study suggests that SBO at spinal level S1 has a higher incidence of posterior disc herniation, the preponderance of clinical literature reports that spina bifida occulta is not a medical problem. The impact literature indicates that lumbosacral vertebral bodies fracture at 7.14 kN in static compression and 20+ G during dynamic vertical impacts. In this paper, we examined the human data observed in ejection seat incidents, the rationale for excluding volunteers with single level SBO and the path of axial load transmission through the lumboscral spine. Based on the findings, we concluded that research volunteers with single level SBO are not at increased risk Tor injury and recommended inclusion of these volunteers in future studies involving repeated axial impacts due to ride motion. RP Albano, JP (reprint author), USA,AEROMED RES LAB,AIRCREW PROTECT DIV,CREW INJURY BRANCH,POB 610577,FT RUCKER,AL 36362, USA. NR 15 TC 3 Z9 3 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD AUG PY 1996 VL 67 IS 8 BP 767 EP 769 PG 3 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA VB434 UT WOS:A1996VB43400006 PM 8853834 ER PT J AU Levine, RF Olson, TA Shoff, PK Miller, MK Weisman, LE AF Levine, RF Olson, TA Shoff, PK Miller, MK Weisman, LE TI Mature micromegakaryocytes: An unusual developmental pattern in term infants SO BRITISH JOURNAL OF HAEMATOLOGY LA English DT Article DE megakaryocytes; fetus; thrombopoiesis; micromegakaryocytes; elutriation ID UMBILICAL-CORD BLOOD; C-MPL LIGAND; NEONATAL THROMBOCYTOPENIA; MEGAKARYOCYTE PROGENITORS; HUMAN-FETAL; GUINEA-PIG; SIZE; MARROW; CELLS; THROMBOPOIESIS AB We sought to gain perspective on platelet production in the fetus and the newborn by counting and characterizing megakaryocytes from available cord blood. Elutriation was used to isolate circulating megakaryocytes from umbilical arteries and veins obtained at scheduled caesarean sections of nine normal term fetuses. Megakaryocytes were identified by established criteria, their diameters measured, and maturation stages recorded. Large numbers of megakargocytes, mostly mature, were found in both the umbilical arteries and veins, many times more than previously observed circulating in adult blood. In term infants more than a third of the mature megakaryocytes had unusually decreased nuclear lobation and were dwarf cells with diameters as small as 13 mu m, which we considered to be micromegakaryocytes. The atypicality of these small but mature cells is seen as merely a leftward skewing in the development of megakaryocyte ploidies. We believe that in normal fetuses the extent of megakaryocyte ploidization and development is distinctive and probably regulated differently to the adult pattern. C1 GEORGE WASHINGTON UNIV, WASHINGTON, DC USA. CHILDRENS HOSP, COLUMBUS, OH 43205 USA. OHIO STATE UNIV, COLUMBUS, OH 43210 USA. WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. HOLY CROSS HOSP, SILVER SPRING, MD 20910 USA. UNIFORMED SERV UNIV HLTH SCI, BETHESDA, MD 20814 USA. RP Levine, RF (reprint author), VET AFFAIRS MED CTR, 50 IRVING ST NW, WASHINGTON, DC 20422 USA. FU NHLBI NIH HHS [HL-35859] NR 48 TC 17 Z9 18 U1 0 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0007-1048 J9 BRIT J HAEMATOL JI Br. J. Haematol. PD AUG PY 1996 VL 94 IS 2 BP 391 EP 399 PG 9 WC Hematology SC Hematology GA VB265 UT WOS:A1996VB26500026 PM 8759904 ER PT J AU YoungMcCaughan, S AF YoungMcCaughan, S TI Sexual functioning in women with breast cancer after treatment with adjuvant therapy SO CANCER NURSING LA English DT Article DE sexual functioning; breast cancer; chemotherapy; endocrine therapy; body image; Roy adaptation model ID ESTROGEN REPLACEMENT THERAPY; QUALITY-OF-LIFE; INDUCED OVARIAN FAILURE; PSYCHOSOCIAL-ASPECTS; POSTMENOPAUSAL WOMEN; TAMOXIFEN THERAPY; HEALTHY WOMEN; BODY-IMAGE; FOLLOW-UP; 1ST YEAR AB The purpose of this research was to describe current sexual functioning in women with breast cancer comparing women treated with chemotherapy or endocrine therapy to women treated without pharmacological manipulation. Sixty-seven women diagnosed with stage I, II, or III breast cancer responded to a two-part mailed questionnaire. The first part of the questionnaire asked about menopausal symptoms (weight changes, hot flashes, mood swings, and anxiety attacks) the women might currently be experiencing and about various symptoms that might be currently interfering with sexual functioning (vaginal dryness, decreased libido, dyspareunia, and difficulty achieving orgasm). The second part of the questionnaire was the Derogatis Sexual Functioning Inventory (DSFI) designed to measure current sexual functioning in ten areas. The women who participated in this study were primarily middle class, white, and married. Controlling for endocrine therapy, the 25 women treated with chemotherapy were 6.5 times more likely than women not treated with chemotherapy to report weight changes (p = 0.001), 3.6 times more likely to report hot flashes (p = 0.02), and 6.5 times more likely to report mood swings (p = 0.001). Additionally, still controlling for endocrine therapy, the women treated with chemotherapy were 5.7 times more likely than women not treated with chemotherapy to report vaginal dryness (p = 0.001), 3.0 times more likely to report decreased libido (p = 0.04), 5.5 times more likely to report dyspareunia (p = 0.003), and 7.1 times more likely to report difficulty achieving orgasm (p = 0.004). Controlling for chemotherapy, the 20 women treated with endocrine therapy did not experience either menopausal or sexual dysfunction symptoms significantly differently from women not treated with endocrine therapy. Controlling for endocrine therapy, there was a significant negative effect of chemotherapy on body image (p = 0.01), affects (p = 0.001), psychological symptoms (p = 0.001), and overall sexual functioning (p = 0.02). However, controlling for chemotherapy, there was no significant effect of endocrine therapy on any of the DSFI subscales. This study indicates that women who have received chemotherapy are especially susceptible to adverse changes in their current sexual functioning. C1 USA,NURSE CORPS,WASHINGTON,DC. MADIGAN ARMY MED CTR,TACOMA,WA 98431. NR 84 TC 81 Z9 81 U1 1 U2 3 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0162-220X J9 CANCER NURS JI Cancer Nurs. PD AUG PY 1996 VL 19 IS 4 BP 308 EP 319 DI 10.1097/00002820-199608000-00007 PG 12 WC Oncology; Nursing SC Oncology; Nursing GA UY561 UT WOS:A1996UY56100007 PM 8768689 ER PT J AU Torrington, KG AF Torrington, KG TI Protocol-driven respiratory therapy - Closing in on appropriate utilization at comparable cost and patient outcomes SO CHEST LA English DT Editorial Material C1 WALTER REED ARMY MED CTR,DEPT MED,PULM & CRIT CARE MED SERV,WASHINGTON,DC 20307. NR 8 TC 2 Z9 2 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD AUG PY 1996 VL 110 IS 2 BP 313 EP 314 DI 10.1378/chest.110.2.313 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA VB923 UT WOS:A1996VB92300006 PM 8697824 ER PT J AU Hibbs, RG Weber, JT Corwin, A Allos, BM ElRehim, MSA ElSharkawy, S Sarn, JE McKee, KT AF Hibbs, RG Weber, JT Corwin, A Allos, BM ElRehim, MSA ElSharkawy, S Sarn, JE McKee, KT TI Experience with the use of an investigational F(ab')(2) heptavalent botulism immune globulin of equine origin during an outbreak of type E botulism in Egypt SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID SERUM SICKNESS AB During an outbreak of type E foodborne botulism in Cairo in 1991, an investigational equine F(ab')(2) ''despeciated'' heptavalent botulism immune globulin (dBIG) was provided to the Egyptian Ministry of Health by the U.S. Army, Of 54 patients known to have been treated with antitoxins, 4 received commercially available trivalent antitoxins, 45 received dBIG, and 5 received both commercial antitoxin and dBIG, Physicians recorded side effects in 10 (22%) of 45 patients who received dBIG; in nine cases, reactions were considered ''mild,'' and in one case they were believed to be serum sickness. In contrast, possible serum sickness during hospitalization was recorded for two of four patients who were receiving commercial antitoxins, No complications of therapy were noted for any patient who was receiving both antitoxin types. In a separate study, 31 patients were contacted about their reactions to the antitoxin by telephone after discharge from the hospital, Seven (54%) of 13 patients attributed symptoms that they experienced while they were hospitalized to receipt of dBIG, while four (44%) of nine patients who indicated that they had received commercial antitoxins and one (20%) of five who received both commercial antitoxin and dBIG reported side effects before discharge, Data on the efficacy of the antitoxins were not obtained. In our experience, equine dBIG was at least as safe as commercially available antitoxins in treating type E foodborne botulism. C1 USN,MED RES UNIT 3,CAIRO,EGYPT. MINIST PUBL HLTH,CAIRO,EGYPT. CTR DIS CONTROL & PREVENT,ATLANTA,GA 30341. USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702. NR 12 TC 58 Z9 61 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD AUG PY 1996 VL 23 IS 2 BP 337 EP 340 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA VA554 UT WOS:A1996VA55400022 PM 8842274 ER PT J AU Arrington, ED Smith, WJ Chambers, HG Bucknell, AL Davino, NA AF Arrington, ED Smith, WJ Chambers, HG Bucknell, AL Davino, NA TI Complications of iliac crest bone graft harvesting SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID DONOR SITE PAIN; LUMBAR HERNIA; FUSION; ANTERIOR; DEFECT AB Autologous bone grafts harvested from the iliac crest are commonly used in reconstructive orthopaedic surgery, Autologous bone is used to help promote bone healing in fractures and to provide structural support for reconstructive surgery, The results of autologous bone grafting are more predictable than the use of xenografts, cadaveric allografts, or synthetic bone substitutes because autologous bone grafts provide osteoinductive and osteoconductive properties, are not immunogenic, and are usually well incorporated into the graft site, In a retrospective review of 414 consecutive cases of iliac crest bone graft procedures performed at Brooke Army Medical Center from 1983 to 1993, 41 (10%) minor and 24 (5.8%) major complications were identified, Minor complications included superficial infections, superficial seromas, and minor hematomas, Major complications included herniation of abdominal contents through massive bone graft donor sites, vascular injuries, deep infections at the donor site, neurologic injuries, deep hematoma formation requiring surgical intervention, and iliac wing fractures, Harvesting of iliac crest bone graft can be associated with significant morbidity, However, with adequate preoperative planning and proper surgical technique, the incidence of these complications can be reduced. C1 BROOKE ARMY MED CTR,DEPT SURG,ORTHOPAED SURG SERV,FT SAM HOUSTON,TX 78234. CHILDRENS HOSP,ORTHOPAED SURG SERV,SAN DIEGO,CA. BAYLOR COLL MED,DEPT ORTHOPAED SURG,HOUSTON,TX 77030. NR 55 TC 684 Z9 704 U1 3 U2 38 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD AUG PY 1996 IS 329 BP 300 EP 309 PG 10 WC Orthopedics; Surgery SC Orthopedics; Surgery GA VC566 UT WOS:A1996VC56600037 ER PT J AU Johnson, AA Tezduyar, TE AF Johnson, AA Tezduyar, TE TI Simulation of multiple spheres falling in a liquid-filled tube SO COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING LA English DT Article ID INCOMPRESSIBLE FLOWS; ELEMENT; COMPUTATION AB A new 3D finite element how simulation capability for fluid-particle interactions is presented and applied to study time-dependent behavior of multiple spheres falling in a liquid-filled tube. This capability is based on the flow simulation strategies such as stabilized space-time formulation for moving boundaries and interfaces, automatic mesh generation with structured layers of elements around the spheres, automatic mesh moving with remesh only as needed, and the implementation of these strategies on massively parallel computing platforms. Several cases of multiple spheres falling in a liquid-filled tube are studied, with the number of spheres ranging from two to five. In all cases, depending on the number of spheres and their initial arrangement, a stable state is eventually reached with all spheres arranged in a pattern corresponding to that stable state, and with all of them falling with the same terminal velocity. C1 UNIV MINNESOTA,ARMY HPC RES CTR,MINNEAPOLIS,MN 55455. RI Tezduyar, Tayfun/F-6134-2012 OI Tezduyar, Tayfun/0000-0001-8707-3162 NR 12 TC 145 Z9 150 U1 0 U2 6 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0045-7825 J9 COMPUT METHOD APPL M JI Comput. Meth. Appl. Mech. Eng. PD AUG 1 PY 1996 VL 134 IS 3-4 BP 351 EP 373 DI 10.1016/0045-7825(95)00988-4 PG 23 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Engineering; Mathematics; Mechanics GA VG767 UT WOS:A1996VG76700010 ER PT J AU Haas, EC Edworthy, J AF Haas, EC Edworthy, J TI Designing urgency into auditory warnings using pitch, speed and loudness SO COMPUTING & CONTROL ENGINEERING JOURNAL LA English DT Article ID PERCEIVED URGENCY AB This article reports an experiment in which the effects of the pitch, speed and the loudness of auditory signals on both subjective perceived urgency and response time are explored. The results show that the signals producing the highest ratings of perceived urgency, as well as the fastest response times, are those with a high frequency, a fast speed and a high level of loudness. Increases in all three parameters produced increases in perceived urgency ratings individually, and increases in pitch and loudness also decreased response time, A modelling approach to perceived urgency is proposed which should enable prescribed levels of urgency to be built into auditory alarms and warnings. C1 UNIV PLYMOUTH,DEPT PSYCHOL,PLYMOUTH PL4 8AA,DEVON,ENGLAND. RP Haas, EC (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. OI Edworthy, Judy/0000-0002-2884-5780 NR 8 TC 32 Z9 32 U1 0 U2 5 PU IEE-INST ELEC ENG PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD, ENGLAND SG1 2AY SN 0956-3385 J9 COMPUT CONTROL ENG J JI Comput. Control Eng. J. PD AUG PY 1996 VL 7 IS 4 BP 193 EP 198 DI 10.1049/cce:19960407 PG 6 WC Automation & Control Systems SC Automation & Control Systems GA VD872 UT WOS:A1996VD87200006 ER PT J AU Chao, SY Boicourt, WC Wang, HVC AF Chao, SY Boicourt, WC Wang, HVC TI Three-layered circulation in reverse estuaries SO CONTINENTAL SHELF RESEARCH LA English DT Article ID MODELS AB Driven by an upper-layer density deficit and lower-layer density surplus from an adjacent sea, circulation in an estuarine embayment may be three-layered, with top and bottom inflows separated by a mid-layer outflow. The characteristics of this type of circulation as functions of density forcing, background stratification and lateral depth variation in an embayment are examined using a three-dimensional primitive-equation model with a free surface. Among all the details, the dominance of bottom intrusion over the surface one stands out and presents a departure from early models that have missed the importance of bottom intrusion in regulating the three-layered circulation. A strong or deeper upper density deficit from the adjacent sea, bottom stress and narrowing estuary width at depths all produce transients discouraging the development of the bottom intrusion. In time, the bottom inflow invariably gains strength and thickness and squeezes up the core of the mid-layer outflow to above the mid-depth. A heuristic argument follows to explain this counter-intuitive result. (C) 1996 Elsevier Science Ltd C1 USA,CORPS ENGINEERS,WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP Chao, SY (reprint author), UNIV MARYLAND,HORN POINT ENVIRONM LAB,CAMBRIDGE,MD 21613, USA. NR 14 TC 11 Z9 11 U1 1 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0278-4343 J9 CONT SHELF RES JI Cont. Shelf Res. PD AUG PY 1996 VL 16 IS 10 BP 1379 EP 1397 DI 10.1016/0278-4343(95)00072-0 PG 19 WC Oceanography SC Oceanography GA UQ378 UT WOS:A1996UQ37800009 ER PT J AU Welch, ML Anderson, LL Grabski, WJ AF Welch, ML Anderson, LL Grabski, WJ TI How many nonmelanoma skin cancers require Mohs micrographic surgery? SO DERMATOLOGIC SURGERY LA English DT Article ID BASAL-CELL CARCINOMA AB BACKGROUND. Cost containment in health care is currently a subject of much debate. The rapid spread of managed cave is an attempt to influence practice trends and contain costs. Although seldom directly stated, it is implied that some physicians may perform high-cost procedures when not necessarily indicated, an example being Mohs micrographic surgery (MMS). OBJECTIVE. There are little data in the literature indicating what percentage of skin cancers treated by MMS would be appropriate. For such data to be meaningful, a model would have to exist wherein there is no financial incentive or disincentive for performing the procedure. Military medicine provides this unique environment. METHODS. In a retrospective review, we counted the total number 4 basal cell carcinomas and squamous cell carcinomas diagnosed at Brooke Army Medical Center (BAMC) over a 5-year period. We then determined the number of MMS cases performed on these cancers. RESULTS. A total of 5193 nonmelanoma skin cancers (NMSC) were diagnosed at BAMC and 1701 of these were treated by MMS. Overall, the percentage of NMSC treated fry MMS was 32.7% for the 5-year period. CONCLUSION. This information may serve as a framework for physicians and health delivery systems as they negotiate managed care contracts for the management of skin cancer. C1 BROOKE ARMY MED CTR,DEPT DERMATOL,DERMATOL SERV,FT SAM HOUSTON,TX 78234. NR 14 TC 15 Z9 15 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 1076-0512 J9 DERMATOL SURG JI Dermatol. Surg. PD AUG PY 1996 VL 22 IS 8 BP 711 EP 713 PG 3 WC Dermatology; Surgery SC Dermatology; Surgery GA VE620 UT WOS:A1996VE62000007 PM 8780764 ER PT J AU Lavery, LA Vela, SA Lavery, DC Quebedeaux, TL AF Lavery, LA Vela, SA Lavery, DC Quebedeaux, TL TI Reducing dynamic foot pressures in high-risk diabetic subjects with foot ulcerations - A comparison of treatments SO DIABETES CARE LA English DT Article ID TOTAL CONTACT CAST; NEUROPATHY AB OBJECTIVE - To compare the effectiveness of total contact casts, commercially available therapeutic shoes, and removable walking casts to reduce mean peak plantar foot pressures at the site of neuropathic ulcerations in diabetic subjects. RESEARCH DESIGN AND METHODS - We compared the reduction in peak plantar pressures at ulcer sites under the great toe (n = 5), first metatarsal (n = 10), and second through fifth metatarsals (n = 10) using six treatments: total contact casts (TCCs), DH Pressure Relief Walkers (DH), Aircast Pneumatic Walkers, Three D Dura-Steppers (3D), CAM Walkers, and P.W. Minor Xtra Depth shoes. A rubber sole canvas oxford was used to establish baseline pressure values. The canvas oxford could be viewed as a worse-case scenario for this patient population. With the EMED Pedar in-shoe pressure measurement system, data for 40 steps were collected for each treatment. We used Tukey's Studentized Range Test for simultaneous multiple comparisons to compare treatments. RESULTS - DH Pressure Relief Walkers reduced plantar pressures significantly better than other commercially available treatments for ulcers under the first metatarsal, second through fifth metatarsals, and great toe (P < 0.05). There was not a significant difference in mean peak plantar pressures between TCCs and DHs at any of the forefoot ulcer sites. CONCLUSIONS - DH Pressure Relief Walkers were as effective as total contact casts to reduce foot pressures at ulcer sites and may be an effective practical addition in the treatment of foot ulcers. C1 MEXICAN AMER MED TREATMENT EFFECTIVENESS RES CTR,SAN ANTONIO,TX. US MIL ACAD,DEPT MATH SCI,W POINT,NY 10996. RP Lavery, LA (reprint author), UNIV TEXAS,HLTH SCI CTR,DEPT ORTHOPAED,SAN ANTONIO,TX 78284, USA. NR 16 TC 109 Z9 110 U1 1 U2 7 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1660 DUKE ST, ALEXANDRIA, VA 22314 SN 0149-5992 J9 DIABETES CARE JI Diabetes Care PD AUG PY 1996 VL 19 IS 8 BP 818 EP 821 DI 10.2337/diacare.19.8.818 PG 4 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA UZ784 UT WOS:A1996UZ78400005 PM 8842597 ER PT J AU Yeh, JJ Pfeffer, RL Cole, MW Ohring, M Yehoda, JE AF Yeh, JJ Pfeffer, RL Cole, MW Ohring, M Yehoda, JE TI Reactions between tungsten and molybdenum thin films and polycrystalline diamond substrates SO DIAMOND AND RELATED MATERIALS LA English DT Article DE diamond; carbides; Rutherford backscattering; metal carbide films ID TITANIUM AB Reactions between thin sputtered tungsten and molybdenum films and polycrystalline diamond substrates were studied in the temperature range 675-1120 degrees C. The mass transport effects and carbides that formed were characterized by Rutherford backscattering (RBS), X-ray diffraction and transmission electron microscopy (TEM) methods. It was found that for tungsten films, W2C formed at low annealing temperatures (800 degrees C), whereas at higher temperatures only WC was observed. For molybdenum films only Mo2C formed. The formation of W2C at the vacuum surface was favored relative to the metal-diamond interface. The reverse was true for Mo2C where, in addition, a surface layer of graphite formed at temperatures of 1020 degrees C. No similar graphite formation occurred in WC films below 1100 degrees C. From both the RBS spectral profiles and TEM observations a model for interstitial and/or grain boundary diffusion assisted carbide formation is suggested. These results for tungsten are consistent with the Bene' rule for the sequence of compound phase formation in metal-metal couples. C1 USA,RES LAB,FT MONMOUTH,NJ 07703. DIAMONEX INC,ALLENTOWN,PA 18106. RP Yeh, JJ (reprint author), STEVENS INST TECHNOL,DEPT MAT SCI & ENGN,HOBOKEN,NJ 07030, USA. NR 11 TC 3 Z9 3 U1 0 U2 4 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0925-9635 J9 DIAM RELAT MATER JI Diam. Relat. Mat. PD AUG PY 1996 VL 5 IS 10 BP 1195 EP 1203 DI 10.1016/0925-9635(96)00528-6 PG 9 WC Materials Science, Multidisciplinary SC Materials Science GA VH527 UT WOS:A1996VH52700020 ER PT J AU Mackay, RA Myers, SA BrajterToth, A AF Mackay, RA Myers, SA BrajterToth, A TI Interpreting diffusion coefficients of electrochemical probes in oil-in-water microemulsions SO ELECTROANALYSIS LA English DT Article DE SDS/dodecane/1-pentanol/0.1M NaClaq anionic oil-in-water microemulsion structure determination; electrochemical methods; ferrocene; Fe(CN)(6)(3-); methyl viologen; apparent diffusion coefficients ID MICRO-EMULSIONS; SELF-DIFFUSION; DODECANE; ASSEMBLIES; SCATTERING; TRANSPORT; MICELLES AB The relationship between apparent diffusion coefficients, D', of electroactive probe and the microstructure of an oil-in-water anionic microemulsion, sodium dodecyl sulfate (SDS)/dodecane/1-pentanol/0.1M NaClaq has been investigated. Three probes, ferrocene (Fc), Fe(CN)(6)(3-) and methyl viologen (MV(2+)) allowed the effect of different microstructure and interactions on the D'-values to be investigated. The results indicate that the droplet as well as bicontinuous microemulsion structures can be identified and point to the effects of cross-phase exchange, partitioning, and multiple binding on the D'-values. C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21020. RP Mackay, RA (reprint author), UNIV FLORIDA,DEPT CHEM,GAINESVILLE,FL 32611, USA. RI brajter-toth, anna/E-8777-2016 NR 30 TC 7 Z9 7 U1 1 U2 8 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 1040-0397 J9 ELECTROANAL JI Electroanalysis PD AUG-SEP PY 1996 VL 8 IS 8-9 BP 759 EP 764 DI 10.1002/elan.1140080810 PG 6 WC Chemistry, Analytical; Electrochemistry SC Chemistry; Electrochemistry GA VL038 UT WOS:A1996VL03800009 ER PT J AU Kanan, AM Wa, PLK Dutta, M Pamulapati, J AF Kanan, AM Wa, PLK Dutta, M Pamulapati, J TI Integrated all-optical routing Y-junction device with ultrafast on/off switching SO ELECTRONICS LETTERS LA English DT Article DE optical switches; integrated optics AB A Y-junction multiquantum well waveguide device using carrier-induced nonlinearities has been tested for all-optical switching. Ultrafast switching is achieved using two consecutive control pulses to turn the device on and off. A switch contrast ratio of 1:2 has been achieved within a switching window of 10ps. C1 USA, RES LAB, ADELPHI, MD 20783 USA. RP UNIV CENT FLORIDA, CREOL, POB 162700, 4000 CENT FLORIDA BLVD, ORLANDO, FL 32816 USA. NR 5 TC 0 Z9 0 U1 0 U2 1 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 0013-5194 EI 1350-911X J9 ELECTRON LETT JI Electron. Lett. PD AUG 1 PY 1996 VL 32 IS 16 BP 1476 EP 1477 DI 10.1049/el:19960997 PG 2 WC Engineering, Electrical & Electronic SC Engineering GA VC805 UT WOS:A1996VC80500034 ER PT J AU Dalsgaard, A Skov, MN Serichantalergs, O Echeverria, P AF Dalsgaard, A Skov, MN Serichantalergs, O Echeverria, P TI Comparison of pulsed-field gel electrophoresis and ribotyping for subtyping of Vibrio cholerae O139 isolated in Thailand SO EPIDEMIOLOGY AND INFECTION LA English DT Article ID RIBOSOMAL-RNA; MOLECULAR CHARACTERIZATION; EPIDEMIC STRAIN; TOXIN GENES; VIBRIO-CHOLERAE-O139; NON-01; BENGAL; BANGLADESH; SEPARATION; RESOLUTION AB Pulsed-field gel electrophoresis (PFGE) of Cpo I-digested genomic DNA and ribotyping (Bgl I) were applied to 60 Vibrio cholerae strains including 48 V. cholerae O139 from Thailand to compare their value in differentiating strains of the present V. cholerae O139 epidemic. PFGE patterns were divided into groups A and B representing five and four subtypes, respectively, while ribotyping showed four different patterns. PFGE group B subtypes were only presented among O139 isolates from Thailand, whereas four O139 strains from Bangladesh and India showed identical PFGE group A subtypes observed in O139 isolates from Thailand. Two nontoxigenic O139 isolates from Thailand showed different and unique PFGE types as did five V. cholerae non-O1 non-O139 isolates containing a gene virulence complex found in V. cholerae O139. These results indicate that PFGE (Cpo I) can resolve recent evolutionary divergence within V. cholerae O139 and offers a useful supplementary tool for following the progressing V. cholerae O139 epidemic. C1 ARMED FORCES RES INST MED SCI,BANGKOK 10400,THAILAND. RP Dalsgaard, A (reprint author), ROYAL VET & AGR UNIV,DEPT VET MICROBIOL,13 BULOWSVEJ,DK-1870 FREDERIKSBERG C,DENMARK. NR 31 TC 17 Z9 18 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 40 WEST 20TH STREET, NEW YORK, NY 10011-4211 SN 0950-2688 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD AUG PY 1996 VL 117 IS 1 BP 51 EP 58 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA VF747 UT WOS:A1996VF74700007 PM 8760950 ER PT J AU Dawson, NA Lush, RM Steinberg, SM Tompkins, AC Headlee, DJ Figg, WD AF Dawson, NA Lush, RM Steinberg, SM Tompkins, AC Headlee, DJ Figg, WD TI Suramin-induced neutropenia SO EUROPEAN JOURNAL OF CANCER LA English DT Article DE prostatic neoplasms; suramin; neutropenia; granulocyte colony-stimulating factor; toxicity ID PROSTATE-CANCER AB This paper presents a retrospective review of 6 cases of severe neutropenia attributed to suramin, the response to granulocyte-colony stimulating factor (G-CSF) and the possible mechanism. Plasma suramin concentrations, G-CSF, platelet-derived growth factor-AB (PDGF-AB) and fibroblast growth factor basic (FGF basic) levels were measured and correlated with neutropenic course. The time course of neutropenia was unpredictable and occurred both during and following discontinuation of suramin. Neutropenia rapidly resolved with G-CSF. Neither the measured growth factor levels nor plasma suramin concentrations correlated with neutropenia. We conclude that neutropenia secondary to suramin is unpredictable and responds to G-CSF administration permitting further suramin therapy. The mechanism remains unknown. C1 NCI,CLIN PHARMACOL BRANCH,BETHESDA,MD 20892. NCI,BIOSTAT & DATA MANAGEMENT SECT,CLIN ONCOL PROGRAM,DIV CANC TREATMENT,BETHESDA,MD 20892. RP Dawson, NA (reprint author), WALTER REED ARMY MED CTR,HEMATOL ONCOL SERV,WASHINGTON,DC 20307, USA. RI Figg Sr, William/M-2411-2016 NR 12 TC 8 Z9 8 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0959-8049 J9 EUR J CANCER JI Eur. J. Cancer PD AUG PY 1996 VL 32A IS 9 BP 1534 EP 1539 DI 10.1016/0959-8049(96)00139-6 PG 6 WC Oncology SC Oncology GA VF742 UT WOS:A1996VF74200026 PM 8911114 ER PT J AU Freytes, CO Vukelja, S Salzman, D Tsai, T Callander, N Gokmen, E Rodriguez, T Castro, J Boldt, D Roodman, GD Hilsenbeck, S Adkins, D Bachier, C Craig, F Clare, N Weisner, A LeMaistre, CF AF Freytes, CO Vukelja, S Salzman, D Tsai, T Callander, N Gokmen, E Rodriguez, T Castro, J Boldt, D Roodman, GD Hilsenbeck, S Adkins, D Bachier, C Craig, F Clare, N Weisner, A LeMaistre, CF TI Autologous hematopoietic stem cell transplantation for poor prognosis low grade lymphoma. SO EXPERIMENTAL HEMATOLOGY LA English DT Meeting Abstract C1 UNIV TEXAS,AUDIE L MURPHY VET HOSP,BROOKE ARMY MED CTR,HLTH SCI CTR,SAN ANTONIO,TX. S TEXAS CANC INST,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CARDEN JENNINGS PUBL CO LTD PI CHARLOTTESVILLE PA BLAKE CTR, STE 200, 1224 W MAIN ST, CHARLOTTESVILLE, VA 22903 SN 0301-472X J9 EXP HEMATOL JI Exp. Hematol. PD AUG PY 1996 VL 24 IS 9 BP 629 EP 629 PG 1 WC Hematology; Medicine, Research & Experimental SC Hematology; Research & Experimental Medicine GA VC092 UT WOS:A1996VC09200628 ER PT J AU Best, EPH Woltman, H Jacobs, FHH AF Best, EPH Woltman, H Jacobs, FHH TI Sediment-related growth limitation of Elodea nuttallii as indicated by a fertilization experiment SO FRESHWATER BIOLOGY LA English DT Article ID VERTICILLATA LF ROYLE; NUTRIENT LIMITATION; MYRIOPHYLLUM-AQUATICUM; SUBMERSED MACROPHYTES; NUTRITION; WATER; AVAILABILITY; POTASSIUM; GRASSLAND; CRITERIA AB 1. A fertilization experiment was performed to identify the limiting nutrient for the growth of submerged vegetation in ditches of a peat-grassland system in the Netherlands, in which restoration measures involved ceasing fertilization, exporting nutrients by removal of above-ground plant mass and large-scale introduction of calcium-rich, nutrient-poor artesian water. 2. Growth of Elodea was significantly enhanced by enrichment with nitrogen alone, and by fertilization with nitrogen in combination with phosphorus, and by nitrogen in combination with phosphorus and potassium. 3. Plant tissue nutrient concentrations increased significantly, for nitrogen by enrichment with nitrogen alone, and with nitrogen in combination with phosphorus and potassium; for phosphorus by enrichment with phosphorus alone and with phosphorus in combination with nitrogen and potassium; tissue concentrations of potassium were not enhanced by any treatment. 4. The elemental ratios of treated plants indicated that nitrogen, rather than phosphorus, was limiting in all treatments, except in those involving nitrogen and NK enrichment (when phosphorus was limiting). 5. The efficiency with which plants used nutrients declined with increased supply of nitrogen and phosphorus, but was unchanged when potassium was increased. Efficiencies were similar to those of other aquatic macrophytes. C1 DLO,INST AGROBIOL & SOIL FERTIL RES,NL-6700 AA WAGENINGEN,NETHERLANDS. RP Best, EPH (reprint author), USACE,ENVIRONM LAB,WATERWAYS EXPT STN,ASCI CORP,VICKSBURG,MS 39180, USA. NR 31 TC 26 Z9 30 U1 3 U2 11 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0046-5070 J9 FRESHWATER BIOL JI Freshw. Biol. PD AUG PY 1996 VL 36 IS 1 BP 33 EP 44 DI 10.1046/j.1365-2427.1996.d01-474.x PG 12 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA VB541 UT WOS:A1996VB54100005 ER PT J AU Kadakia, SC Wrobleski, CS Kadakia, AS Meier, NJ AF Kadakia, SC Wrobleski, CS Kadakia, AS Meier, NJ TI Prevalence of proximal colonic polyps in average-risk asymptomatic patients with negative fecal occult blood tests and flexible sigmoidoscopy SO GASTROINTESTINAL ENDOSCOPY LA English DT Article ID COLORECTAL-CANCER; SCREENING SIGMOIDOSCOPY; LARGE BOWEL; ADENOMAS; POLYPECTOMY; COLONOSCOPY; PREVENTION; MORTALITY; AUTOPSY; MEN AB Background: Proximal colonic adenomas were found in 13% to 37% of patients without distal adenomas who underwent colonoscopy, Fiberoptic flexible sigmoidoscopy (FFS) was not performed prior to colonoscopy in all studies except one, The proximal colon at colonoscopy was defined as that portion of the colon proximal to either the descending-sigmoid junction or 60 cm from the anus while withdrawing the colonoscope, These estimates may not reflect exact colonic location when a 60 cm length sigmoidoscope is fully inserted, Therefore, the aim of our study was to determine the prevalence of proximal colonic neoplasms in asymptomatic patients with average risk for colon cancer, aged 50 years and over, with negative fecal occult blood tests and without adenomas at FFS, Methods: Colonoscopy was performed in 80 patients without and 95 patients with adenomas at FFS. Polypectomy was done using hot biopsy forceps or snare cautery. Results: Twenty-four proximal colonic adenomas (19 <1 cm and 5 greater than or equal to 1 cm) were found in 18 of 80 patients (23%) with normal FFS compared with 39 proximal colonic adenomas (32 <1 cm and 7 greater than or equal to 1 cm), in 28 of 95 patients (29%) with adenomas at FFS (p = 0.31), In patients with normal FFS, there were 20 tubular, 2 tubulovillous, and 2 villous (1 with severe dysplasia) adenomas, In patients with adenomas at FFS, there were 31 tubular, 5 tubulovillous, and 3 villous (1 with severe dysplasia) adenomas, Conclusions: Proximal colonic adenomas are found in up to one fourth of asymptomatic average-risk patients with negative fecal occult blood test and both with and without adenomas at FFS. The adenomas in both groups have similar size, histology, and location. Severe dysplasia is rarely present. C1 BROOKE ARMY MED CTR,DEPT MED,INTERNAL MED SERV,FT SAM HOUSTON,TX 78234. RP Kadakia, SC (reprint author), BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234, USA. NR 29 TC 47 Z9 47 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD AUG PY 1996 VL 44 IS 2 BP 112 EP 117 DI 10.1016/S0016-5107(96)70126-8 PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA VE180 UT WOS:A1996VE18000002 PM 8858314 ER PT J AU Hunter, LE Powell, RD Smith, GW AF Hunter, LE Powell, RD Smith, GW TI Facies architecture and grounding-line fan processes of morainal banks during the deglaciation of coastal Maine SO GEOLOGICAL SOCIETY OF AMERICA BULLETIN LA English DT Article ID BAFFIN-ISLAND; GLACIOMARINE SEDIMENTATION; DEPOSITIONAL MODEL; TIDEWATER GLACIER; ICE-SHEET; FJORDS; ALASKA; SEA; SPITSBERGEN; MELTWATER AB Submarine jet processes are inferred from glaciomarine facies exposed in gravel pits in southwestern coastal Maine. The geometry and distribution of fan facies depend on (1) the proximity to the grounding line and stream effluxes, (2) the angle of jet trajectory from glacier conduits, and (3) sediment remobilization processes. Syndepositional glaciotectonic deformation further augments morainal bank formation through pushing and squeezing of fan sediments at the grounding line. Complex process-sediment interactions along the temperate tidewater margin of the Laurentide ice sheet are recorded in the facies architecture of sedimentary sequences in morainal banks. Morainal bank accumulation was governed by rapid fluvial deposition, and outwash jet dynamics that controlled the spatial distribution of sedimentary facies. Near the grounding line, meltwater dynamics change rapidly where sediment-laden fresh water is discharged at or near the sea floor. Turbulent mixing with ambient sea water and discharge fluctuations cause rapid changes in flow competence, accompanied by the dumping of bed-load gravel and sand at the apices of grounding-line fans in the morainal banks. Jet trajectory relative to the morainal bank slope determines whether a jet will make contact with the morainal bank. Gravel and sand remain in bed-load traction as long as the jet is in contact with the morainal bank. Bed-load dumping and settling of the coarse suspended load occurs where buoyant forces in the jet overcome momentum forces or where the jet is deflected by the morainal bank. Below these buoyant jets, backflow eddies can produce currents that drive ripple migration toward the grounding line. Abrupt facies changes record fluctuations in jet discharge and trajectory and sediment redistribution by sediment gravity flows initiated near the grounding line. C1 NO ILLINOIS UNIV,DEPT GEOL,DE KALB,IL 60115. OHIO UNIV,DEPT GEOL,ATHENS,OH 45701. RP Hunter, LE (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 78 TC 31 Z9 33 U1 0 U2 2 PU GEOLOGICAL SOC AMERICA PI BOULDER PA PO BOX 9140 3300 PENROSE PLACE, BOULDER, CO 80301 SN 0016-7606 J9 GEOL SOC AM BULL JI Geol. Soc. Am. Bull. PD AUG PY 1996 VL 108 IS 8 BP 1022 EP 1038 DI 10.1130/0016-7606(1996)108<1022:FAAGLF>2.3.CO;2 PG 17 WC Geosciences, Multidisciplinary SC Geology GA VC461 UT WOS:A1996VC46100009 ER PT J AU Mengel, SA Adams, WJ AF Mengel, SA Adams, WJ TI The need for a hypertext instructional design methodology SO IEEE TRANSACTIONS ON EDUCATION LA English DT Article AB Educators are showing an interest in media rich presentation systems as a means of giving additional material to a class or of showing concepts in a graphical fashion during class, Educators have concerns, however, about the length of time it takes to design and implement media rich or multimedia systems, about copyright issues, and whether the system will be used more than once, They also want to be able to design the system using sound instructional principles, but may not have any time for acquiring such specialized knowledge and, indeed, they probably did not take any education classes while working on their advanced degrees, They do not want to spend a great deal of time in learning how to use a multimedia package nor do their students who may only need to do a multimedia system once to fulfill the requirements of a project or degree. Although educators and students could use expensive instructional design and multimedia packages, they can accomplish the same objectives with the World Wide Web (WWW) using the hypertext markup language (HTML) and SIMPLE designed by M. Hagler and B. Marcy at Texas Tech University. Both are easy to learn to use in a short period of time and are free to educators and students, Currently, however, neither HTML or SIMPLE incorporate instructional design, hypertext design, or interface design nor were they implemented to do so, HTML provides a mechanism for allowing media rich presentations to be made on the WWW and SIMPLE lets instructors pull already designed and implemented instructional materials together into a whole. To help educators and students design effective and instructionally sound systems quickly, a hypertext instructional design engineering process can be used to help them to concentrate on structuring their system and on monitoring design violations, The process includes a requirements stage, a specifications stage, an implementation stage, validation for each stage, and evaluation of the resulting system, The products of these stages are developed with object-oriented techniques which will eventually result in a hypertext system for instructional usage, The process has been utilized to develop a system for teaching machinists how to use a computer numerically controlled machine, It is currently being used for designing and implementing a network protocol analyzer tutorial and WWW courseware. C1 US MIL ACAD, DEPT ELECT ENGN & COMP SCI, W POINT, NY 10996 USA. RP Mengel, SA (reprint author), TEXAS TECH UNIV, LUBBOCK, TX 79409 USA. NR 8 TC 7 Z9 7 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9359 EI 1557-9638 J9 IEEE T EDUC JI IEEE Trans. Educ. PD AUG PY 1996 VL 39 IS 3 BP 375 EP 380 DI 10.1109/13.538761 PG 6 WC Education, Scientific Disciplines; Engineering, Electrical & Electronic SC Education & Educational Research; Engineering GA VL208 UT WOS:A1996VL20800014 ER PT J AU Weiss, SJ Kahn, WK AF Weiss, SJ Kahn, WK TI Measurement of simple resonant equivalent circuits for microstrip antennas SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article AB This paper presents a procedure which can be used to model the input admittance of a probe-fed microstrip antenna using simple circuit components, The values of the components are extracted from experimental data and represent the antenna about any resonant mode, A good circuit description of the antenna can greatly facilitate system analysis. C1 GEORGE WASHINGTON UNIV,SCH ENGN & APPL SCI,DEPT ELECT ENGN & COMP SCI,WASHINGTON,DC 20052. RP Weiss, SJ (reprint author), USA,ARMAMENT RES DEV & ENGN CTR,ADELPHI,MD 20783, USA. NR 4 TC 1 Z9 1 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD AUG PY 1996 VL 44 IS 8 BP 1513 EP 1516 DI 10.1109/22.536041 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA VC774 UT WOS:A1996VC77400021 ER PT J AU Neill, RJ Jett, M Crane, R Wootres, J Welch, C Hoover, D Gemski, P AF Neill, RJ Jett, M Crane, R Wootres, J Welch, C Hoover, D Gemski, P TI Mitogenic activities of amino acid substitution mutants of staphylococcal enterotoxin B in human and mouse lymphocyte cultures SO INFECTION AND IMMUNITY LA English DT Article ID TOXIC SHOCK SYNDROME; HUMAN PERIPHERAL LYMPHOCYTES; T-CELLS; BINDING-SITES; AUREUS; SUPERANTIGEN; SPECIFICITY; RECEPTOR; GENE; LOCALIZATION AB Site-directed mutagenesis has been used to introduce amino acid substitutions at specific residues of the staphylococcal enterotoxin B (SEB) gene cloned from Staphylococcus aureus 10-275. The mitogenic activities of these derivatives were determined in two assay systems: (i) mouse spleen cells and (ii) a mixture of human peripheral blood mononuclear cells and lymphocytes. Substitution of either His-12, His-32, His-121, His-166, Lys-152, or Gly-205 did not significantly alter the mitogenic activity from that of the wild-type toxin in either proliferation assay. Substitution of either residue Asn-23, Phe-44, or Cys-93 reduced the mitogenicity of SEB by a degree that depended upon the assay system used. Similar to the results reported by others measuring toxin activation of mouse lymphoid cells, we found that substitutions of these three residues of SEB caused at least 800-fold reductions of mitogenic activity from that of the wild-type toxin. When tested for toxicity in vivo in D-galactosamine-treated mice, the reduced activities of these mutant toxins, however, were not as pronounced, In contrast, when tested in the human cell mitogenicity assay, these mutant toxins were active. Small alterations in activity (two- to fivefold reduction) were observable only at low concentrations. Our findings reveal the importance of using human lymphocytes in addition to the traditional mouse spleen cell assay when assessing biological activities of staphylococcal enterotoxins. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. RP Neill, RJ (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV PATHOL,BLDG 40,RM 1051,WASHINGTON,DC 20307, USA. NR 61 TC 13 Z9 14 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD AUG PY 1996 VL 64 IS 8 BP 3007 EP 3015 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA UY893 UT WOS:A1996UY89300020 PM 8757827 ER PT J AU Jordan, JB Watkins, WR Palacios, FR Billingsley, DR AF Jordan, JB Watkins, WR Palacios, FR Billingsley, DR TI Simulated dynamic effects of atmospheric turbulence on IR digital imagery SO INFRARED PHYSICS & TECHNOLOGY LA English DT Article DE infrared imaging; atmospheric turbulence; simulation AB An efficient approximation method for simulating the dynamic effects of atmospheric turbulence on infrared digital imagery is presented. The method is based on the distant phase screen approximation for certain atmospheric turbulent conditions and is an application of the theoretical work published by M.I. Charnotskii et al. in 1990. The computational simplicity of the method allows realistic incorporation of the turbulence effects in high resolution interactive simulation environments for military and commercial applications. Simulations of turbulence effects on digital infrared images are presented together with actual images obtained from a commercial 8 to 12 mu m infrared system imaging through thermally induced atmospheric turbulence. C1 USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP Jordan, JB (reprint author), NEW MEXICO STATE UNIV,DEPT ELECT & COMP ENGN,POB 30001,DEPT 3-0,LAS CRUCES,NM 88003, USA. NR 19 TC 3 Z9 3 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 1350-4495 J9 INFRARED PHYS TECHN JI Infrared Phys. Technol. PD AUG PY 1996 VL 37 IS 5 BP 607 EP 617 DI 10.1016/1350-4495(95)00127-1 PG 11 WC Instruments & Instrumentation; Optics; Physics, Applied SC Instruments & Instrumentation; Optics; Physics GA UR652 UT WOS:A1996UR65200004 ER PT J AU Kim, JH McLinden, RJ Mosca, JD Burke, DS Boswell, RN Birx, DL Redfield, RR AF Kim, JH McLinden, RJ Mosca, JD Burke, DS Boswell, RN Birx, DL Redfield, RR TI Transcriptional effects of superinfection in HIV chronically infected T cells: Studies in dually infected clones SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE HIV-1 superinfection; dual infection; transcription HIV-1 ID HUMAN-IMMUNODEFICIENCY-VIRUS; III HTLV-III; TYPE-1 DNA; EXPRESSION; LATENCY; LINES; INTERFERENCE; ACCUMULATION; GENE; TAT AB We had previously shown that chronically infected ACH-2 cells (HIVLAI) could be superinfected with HIVRF, that the frequency of superinfection increased with time, and that the transcription of the superinfecting virus exceeded that of the host HIVLAI provirus. In contrast, ACH-2 cells superinfected with a nef-substituted neomycin-resistant (proNEO) provirus were not detectable by DNA polymerase chain reaction (PCR) until geneticin (G418) was added, suggesting that the ability to propagate progressively in culture may be HIV strain specific. Clonal populations of ACH-2 superinfected with proNEO did not demonstrate preferential transcription of the superinfecting virus. However, clones of ACH-2 superinfected with HIVRF (ACH2/RF) showed a preponderance of HIVRF transcripts similar to that seen in bulk populations. Induction of the superinfecting virus by phorbol ester (PMA) occurred more rapidly than the host provirus and did not equalize transcriptional activity. PCR-derived long terminal repeat (LTR) fragments and Tat cDNAs from A3.01 cells acutely infected with HIVRF or from ACH-2 cells were sequenced and tested for transactivation. The HIVLAI LTR was two to three times more Tat-responsive than the HIVRF LTR. Tat(RF) was two to three times more transcriptionally active on either LTR than Tat(LAI). Demethylation with 5-azacytidine did not significantly affect HIV expression from the HIVLAI host provirus of superinfected ACH2/RF cell clones. These data suggest that the mechanism of preferential transcription in HIVRF superinfected ACH2/RF may be attributed to the Tat/TAR axis and the effect of the specific locus of host proviral integration. C1 HENRY M JACKSON FDN,ROCKVILLE,MD. UNIV MARYLAND,INST BIOTECHNOL,BALTIMORE,MD 21201. UNIV MARYLAND,INST HUMAN VIROL,BALTIMORE,MD 21201. RP Kim, JH (reprint author), WALTER REED ARMY INST RES,DIV RETROVIROL,13 TAFT COURT,SUITE 200,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 NR 35 TC 9 Z9 10 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD AUG 1 PY 1996 VL 12 IS 4 BP 329 EP 342 PG 14 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA UY965 UT WOS:A1996UY96500002 PM 8673541 ER PT J AU Kim, JH McLinden, RJ Mosca, JD Vahey, MT Greene, WC Redfield, RR AF Kim, JH McLinden, RJ Mosca, JD Vahey, MT Greene, WC Redfield, RR TI Inhibition of HIV replication by sense and antisense Rev response elements in HIV-based retroviral vectors SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE TAT; REV; retroviral vectors; Rev response element (RRE) ID HUMAN-IMMUNODEFICIENCY-VIRUS; HTLV-I REX; GENE-EXPRESSION REQUIRES; TRANS-ACTIVATOR GENE; CIS-ACTING SEQUENCES; TARGET SEQUENCE; MESSENGER-RNA; SECONDARY STRUCTURE; TYPE-1 REPLICATION; PROTEIN AB The life cycle of human immunodeficiency virus type 1 (HIV-I) is critically dependent on the transregulatory proteins Tat and Rev. Tat increases the production of HIV-specific mRNAs by direct binding to the transactivation response (TAR) element located at the 5' end of all HIV transcripts. In contrast, Rev uses a complex RNA stem loop structure, the Rev response element (RRE), which is found in full-length and singly spliced HIV transcripts, Rev is required for the cytoplasmic expression of full-length mRNAs encoding Gag, Pol, and Env structural proteins. The complex intracellular interactions between Tat, Rev, host cell factors, and their respective RNA response elements should be susceptible to interdiction by genetic therapies designed to introduce and express novel genetic information. We show that the expression of antisense RREs inhibited the cytoplasmic expression of RRE containing HIV-I transcripts. HIV-based retroviral vectors containing either the antisense (-) or sense (+)RREs inhibited HIV replication in transient transfections. The production of full-length HIV mRNA was also decreased significantly by the expression of RREs in either orientation. Interestingly, there was a paradoxic increase in HIV p24 gag production at low levels of inhibitor; this effect may have been the result of encapsidation of RRE-containing HIV-based retroviral vectors. The data suggest that the introduction and inducible expression of RRE-containing, HIV-based retroviral vectors may have therapeutic value in HIV infection. C1 WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD. HENRY M JACKSON FDN,ROCKVILLE,MD. GLADSTONE INST VIROL & IMMUNOL,SAN FRANCISCO,CA. RP Kim, JH (reprint author), UNIV MARYLAND,CTR MED BIOTECHNOL,INST HUMAN VIROL,721 W LOMBARD ST,BALTIMORE,MD 21201, USA. FU NIAID NIH HHS [K11 AI00950-02] NR 60 TC 16 Z9 16 U1 0 U2 2 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD AUG 1 PY 1996 VL 12 IS 4 BP 343 EP 351 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA UY965 UT WOS:A1996UY96500003 PM 8673542 ER PT J AU Andreas, EL Cash, BA AF Andreas, EL Cash, BA TI A new formulation for the Bowen ratio over saturated surfaces SO JOURNAL OF APPLIED METEOROLOGY LA English DT Article ID TURBULENT FLUXES; SEA-SURFACE; ICE; ROUGHNESS; SNOW; HEAT AB Analytical expressions are presented for calculating the Bowen ratio, Bo = H-s/H-L, from a quantity Bo* that is derived primarily from the surface temperature T-s and the assumption that the near-surface air is saturated (but not supersaturated) with water vapor. Here H-s is the surface sensible heat flux, and H-L is the surface latent heat flux. These analytical expressions obtained from 17 tabulations of H-s, H-L, and T-s taken from the literature were examined. These data came from experiments over snow-covered ground and sea ice and over water in the Great Lakes, the marginal seas, and the open ocean at a variety of latitudes. Surface temperatures ranged from -41 degrees to 29 degrees C. Over 90% of the data fell into one of three heat flux cases: H-s > 0 and H-L > 0, H-s < 0 and H-L < 0, or H-s < 0 and H-L > 0. From the tabulated data, a single equation that relates Bo to Bo* (T-s) for each case is developed, unifying the prediction of Bo from T-s for most saturated surfaces on earth. Last, the sensitivity of Bo to uncertainties in the quantities needed to estimate it is investigated. This analysis suggests that the analytical expressions should generally predict Bo to better than +/-40%. It is concluded that predicting Bo from surface temperature alone yields good results for large-scale or longer time (e.g., daily) averages but is less accurate when both the spatial and temporal averaging are limited. Consequently, the results will probably find most use in global climate models, in coupled ice-ocean-atmosphere models, and for data assimilation and quality control. RP Andreas, EL (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 34 TC 34 Z9 36 U1 0 U2 5 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 SN 0894-8763 J9 J APPL METEOROL JI J. Appl. Meteorol. PD AUG PY 1996 VL 35 IS 8 BP 1279 EP 1289 DI 10.1175/1520-0450(1996)035<1279:ANFFTB>2.0.CO;2 PG 11 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA VE128 UT WOS:A1996VE12800010 ER PT J AU Lee, CC Cui, HL Cai, J Lenzing, E Pastore, R Rhodes, D Perlman, BS AF Lee, CC Cui, HL Cai, J Lenzing, E Pastore, R Rhodes, D Perlman, BS TI Transient device modeling using the Lei-Ting hydrodynamic balance equations SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SEMICONDUCTOR-DEVICES; NUMERICAL-SIMULATION; ENERGY-BALANCE; ALGORITHM; SCHEME AB A transient semiconductor device simulation model based on the recently developed Lei-Ting hydrodynamic balance equations is presented. Unlike other hydrodynamic models, where the various relaxation rates are imported from Monte Carlo calculations or simply assumed to be constant, our model calculates these relaxation rates within the simulation process, as functions of the electron drift velocity, electron temperature, as well as the electron density. Without any complicated mathematics, a decoupled method with a relatively large time step has been applied to the transient simulation on a one-dimensional ballistic diode. (C) 1996 American Institute of Physics. C1 USA,RES LAB,FT MONMOUTH,NJ 07703. RP Lee, CC (reprint author), STEVENS INST TECHNOL,DEPT PHYS & ENGN PHYS,HOBOKEN,NJ 07030, USA. NR 20 TC 5 Z9 6 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD AUG 1 PY 1996 VL 80 IS 3 BP 1891 EP 1900 DI 10.1063/1.363003 PG 10 WC Physics, Applied SC Physics GA VA594 UT WOS:A1996VA59400094 ER PT J AU Sun, SF OliverPickett, C Ping, Y Micco, AJ Droma, T Zamudio, S Zhuang, JG Huang, SY McCullough, RG Cymerman, A Moore, LG AF Sun, SF OliverPickett, C Ping, Y Micco, AJ Droma, T Zamudio, S Zhuang, JG Huang, SY McCullough, RG Cymerman, A Moore, LG TI Breathing and brain blood flow during sleep in patients with chronic mountain sickness SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE Tibet; sleep-disordered breathing; arterial oxygen saturation; Doppler flow velocity; high altitude; hypoxia; China ID EYE-MOVEMENT SLEEP; HIGH-ALTITUDE; EXCESSIVE POLYCYTHEMIA; CEREBRAL HEMODYNAMICS; VELOCITY; APNEA; RESPIRATION; RESIDENTS; HYPOPNEA AB Chronic mountain sickness (CMS) patients have lower arterial O-2 saturation (Sa(O2)) during sleep compared with healthy high-altitude residents, but whether nocturnal arterial Oa content (Ca-O2) and brain O-2 delivery are reduced is unknown. We measured Sa(O2), Ca-O2, sleep-disordered breathing (SDB), and internal carotid artery flow velocity in 8 CMS patients, 8 age-matched healthy CMS controls, 11 healthy younger-aged Han, and 11 healthy younger-aged Tibetan male residents of Lhasa, Tibet (3,658 m). CMS patients spent a greater portion of the night in SDB (total no. of episodes of apnea, hypopnea, and hypoventilation) than did the CMS controls, young Han, or young Tibetans (15% vs. 5, 1, and 1%, respectively; P < 0.05) because of more frequent apnea and hypoventilation episodes and longer duration of all types of episodes. SDB and unexplained arterial O-2 desaturation caused nocturnal Sa(O2) to be lower and more variable in CMS patients than in CMS controls or in younger-aged Han or Tibetan men. Average Ca-O2 was similar, but the CMS patients spent 29%, whereas the other groups spent <4%, of the night at values <18 ml O-2/100 ml whole blood. Internal carotid artery flow velocity during wakefulness was similar in CMS patients and CMS controls despite higher end-tidal Pco(2) values in the CMS patients. When contiguous sleep stages are compared, flow velocity rose from stage 2 to rapid-eye-movement sleep in both groups. Whereas flow velocity remained elevated from awake to rapid-eye-movement sleep in the CMS controls, it fell in the CMS patients. During episodes of SDB, internal carotid flow velocity increased in CMS controls but did not change in the CMS patients such that values were lower in the CMS patients than in CMS controls at the end and after SDB episodes. We concluded that SDB and episodes of unexplained desaturation lowered nocturnal Sa(O2) and Ca-O2, which, together with a lack of compensatory increase in internal carotid artery flow velocity, likely decreased brain O-2 delivery in CMS patients during a considerable portion of the night. C1 UNIV COLORADO,HLTH SCI CTR B133,CARDIOVASC PULM RES LAB,DENVER,CO 80262. UNIV COLORADO,HLTH SCI CTR,DEPT ANESTHESIOL,DENVER,CO 80262. UNIV COLORADO,DEPT ANTHROPOL,DENVER,CO 80217. USA,MED RES & DEV COMMAND,ALTITUDE PHYSIOL & MED DIV,NATICK,MA 01760. TIBET INST MED SCI,LHASA 85000,TIBET,PEOPLES R CHINA. RI Sanguansri, Luz/B-6630-2011 OI Sanguansri, Luz/0000-0003-1908-7604 FU NHLBI NIH HHS [HL-14985] NR 31 TC 43 Z9 43 U1 0 U2 3 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD AUG PY 1996 VL 81 IS 2 BP 611 EP 618 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA VD228 UT WOS:A1996VD22800013 PM 8872625 ER PT J AU Sawka, MN Young, AJ Rock, PB Lyons, TP Boushel, R Freund, BJ Muza, SR Cymerman, A Dennis, RC Pandolf, KB Valeri, CR AF Sawka, MN Young, AJ Rock, PB Lyons, TP Boushel, R Freund, BJ Muza, SR Cymerman, A Dennis, RC Pandolf, KB Valeri, CR TI Altitude acclimatization and blood volume: Effects of exogenous erythrocyte volume expansion SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE erythropoietin; hypoxia; mean arterial pressure; plasma protein; plasma volume ID TOTAL-BODY WATER; PLASMA-VOLUME; HYPOBARIC HYPOXIA; NITRIC-OXIDE; ERYTHROPOIETIN; EXERCISE; EXPOSURE; HUMANS; MEN AB We studied sea-level residents during 13 days of altitude acclimatization to determine 1) altitude acclimatization effects on erythrocyte volume and plasma volume, 2) if exogenous erythrocyte volume expansion alters subsequent erythrocyte volume and plasma volume adaptations, 3) if an increased blood oxygen content alters erythropoietin responses during altitude acclimatization, and 4) mechanisms responsible for plasma loss at altitude. Sixteen healthy men had a series of hematologic measurements made at sea level, on the first and ninth days of altitude (4,300 m) residence, and after returning to sea level. Twenty-four hours before the ascent to altitude, one group received a 700-ml infusion of autologous erythrocytes (42% hematocrit), whereas the other group received only a saline infusion. Erythrocyte infusion increased erythrocyte volume by similar to 10%, whereas saline-infusion had no effect; in addition, initially at altitude, blood oxygen content was 8% higher in erythrocyte-infused than in saline-infused subjects. The new findings regarding altitude acclimatization are summarized as follows: 1) erythrocyte volume does not change during the first 13 days and is not affected by prior exogenous expansion, 2) a modest increase in blood oxygen content does not modify erythropoietin responses, 3) plasma losses are related to vascular protein losses, and 4) exogenous erythrocyte volume expansion coincides with transient increases in plasma loss, vascular protein loss, and mean arterial pressure elevation. These findings better define human blood volume responses during altitude acclimatization. C1 BOSTON UNIV,MED CTR,NAVAL BLOOD RES LAB,BOSTON,MA 02118. RP Sawka, MN (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 45 TC 37 Z9 38 U1 0 U2 3 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD AUG PY 1996 VL 81 IS 2 BP 636 EP 642 PG 7 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA VD228 UT WOS:A1996VD22800016 PM 8872628 ER PT J AU Meter, JJ Polly, DW Brueckner, RP Tenuta, JJ Asplund, L Hopkinson, WJ AF Meter, JJ Polly, DW Brueckner, RP Tenuta, JJ Asplund, L Hopkinson, WJ TI Effect of intraoperative blood loss on the serum level of cefazolin in patients managed with total hip arthroplasty - A prospective controlled study SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID PROPHYLACTIC CEFAZOLIN; LONG-TERM; PHARMACOKINETICS; REPLACEMENT; ANTIBIOTICS; SURGERY; PREVENTION; PLACEBO; SEPSIS AB The effect of intraoperative blood loss on serum levels of cefazolin in patients being managed with total hip arthroplasty was studied. Eighteen patients, thirteen men and five women, with a mean age of sixty-five years (range, forty to eighty-five years) were enrolled in the study. Fifteen had a primary total hip arthroplasty and three, a revision. Each patient served as his or her own control. Baseline clearance of cefazolin was determined at a minimum of forty-eight hours before the operation. Each patient received one gram of cefazolin intravenously. Serial serum concentrations were determined from specimens drawn at zero, five, ten, twenty, thirty, sixty, 120, 240, and 300 minutes after administration. Fifteen minutes before the skin incision was made, each patient again received one gram of cefazolin intravenously. Serum samples were collected at the same time-intervals, and the serum levels of cefazolin were determined with use of capillary electrophoresis. Data regarding intraoperative blood loss as well as replacement of fluid and blood were recorded. The administration of the antibiotic, retrieval of the serum samples, and estimation of the blood loss were performed by the same person in the same manner for all patients. The preoperative and intraoperative creatinine clearances (mean and standard deviation), estimated with use of the formula of Cockcroft and Gault, were 62.06 +/- 21.28 and 74.02 +/- 24.75 milliliters per minute, respectively. The amount of intraoperative blood loss averaged 1137 +/- 436 milliliters (range, 675 to 2437 milliliters). The preoperative and intraoperative cefazolin clearances averaged 0.49 +/- 0.21 and 0.52 +/- 0.30 milliliter per minute per kilogram, respectively. During joint replacement, the commonly accepted interval between doses of cefazolin is four hours. In the present study, the serum level of cefazolin at four hours was forty-five micrograms per milliliter. This corresponds to an osseous concentration that well exceeds the minimum inhibitory concentration for Staphylococcus aureus, which is 0.5 microgram per milliliter. This study suggests that, with blood losses of more than 2000 milliliters, it is not necessary to administer cefazolin at intraoperative intervals of less than four hours in order to maintain a concentration of antibiotics that is higher than the minimum inhibitory concentration for the most common infecting organisms. C1 WALTER REED ARMY MED CTR,ORTHOPAED SURG SERV,WASHINGTON,DC 20307. LOYOLA UNIV,MED CTR,DEPT ORTHOPAED SURG,MAYWOOD,IL 60153. NR 26 TC 15 Z9 15 U1 0 U2 1 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD AUG PY 1996 VL 78A IS 8 BP 1201 EP 1205 PG 5 WC Orthopedics; Surgery SC Orthopedics; Surgery GA VD024 UT WOS:A1996VD02400010 PM 8753712 ER PT J AU Peterson, KA Armstrong, S Moseley, J AF Peterson, KA Armstrong, S Moseley, J TI Pathologic crying responsive to treatment with sertraline SO JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY LA English DT Letter ID STROKE C1 WALTER REED ARMY MED CTR,CONSULT LIAISON SERV,WASHINGTON,DC. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP Peterson, KA (reprint author), WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20307, USA. NR 5 TC 2 Z9 2 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0271-0749 J9 J CLIN PSYCHOPHARM JI J. Clin. Psychopharmacol. PD AUG PY 1996 VL 16 IS 4 BP 333 EP 333 DI 10.1097/00004714-199608000-00011 PG 1 WC Pharmacology & Pharmacy; Psychiatry SC Pharmacology & Pharmacy; Psychiatry GA UZ313 UT WOS:A1996UZ31300011 PM 8835711 ER PT J AU Barrett, TL Skelton, HG Smith, KJ OGrady, TC ProctorShipman, L AF Barrett, TL Skelton, HG Smith, KJ OGrady, TC ProctorShipman, L TI Ossifying fibromyxoid tumor of soft parts: A case report and review SO JOURNAL OF CUTANEOUS PATHOLOGY LA English DT Article ID TISSUE TUMOR AB Ossifying fibromyxoid tumor of soft parts is a recently described, rare but morphologically distinctive tumor of soft tissue, including subcutaneous soft tissue. We report a case of ossifying fibromyxoid tumor of soft parts which occurred in the subcutaneous tissue of a 68-year-old male, and review the clinical, histologic, and immunohistologic features of this tumor. Ossifying fibromyxoid tumor of soft parts tends to occur in the subcutaneous tissue and have been reported from the head and neck, upper and lower extremities, and trunk. Immunohistologic studies have supported a neural origin. While considered benign, local recurrence after excision is common and these tumors should be excised with clear margins to prevent recurrence. C1 ARMED FORCES INST PATHOL, DEPT DERMATOPATHOL, WASHINGTON, DC 20306 USA. NAVAL MED CTR, DEPT DERMATOL, SAN DIEGO, CA USA. USA, MED RES INST CHEM DEF, ABERDEEN PROVING GROUND, MD 21010 USA. NR 12 TC 11 Z9 11 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0303-6987 J9 J CUTAN PATHOL JI J. Cutan. Pathol. PD AUG PY 1996 VL 23 IS 4 BP 378 EP 380 DI 10.1111/j.1600-0560.1996.tb01314.x PG 3 WC Dermatology; Pathology SC Dermatology; Pathology GA VC508 UT WOS:A1996VC50800016 PM 8864928 ER PT J AU Benson, JD Cornfeld, AB Martinka, M Singley, KM Derzko, Z Shorten, PJ Dinan, JH AF Benson, JD Cornfeld, AB Martinka, M Singley, KM Derzko, Z Shorten, PJ Dinan, JH TI In-situ spectroscopic ellipsometry of HgCdTe SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 1995 US Workshop on the Physics and Chemistry of Mercury Cadmium Telluride and Other IR Materials CY OCT 10-12, 1995 CL BALTIMORE, MD DE molecular beam epitaxy; spectroscopic ellipsometry ID REAL-TIME CONTROL; NONDESTRUCTIVE ANALYSIS; GROWTH; HG1-XCDXTE AB An in-situ spectroscopic ellipsometer has been equipped on a molecular beam epitaxy system to improve control of HgCdTe growth. Using this device, in-situ analysis of composition, growth rate, and surface cleanliness were monitored. A real time model which determined the compositional profile was used. The ellipsometer was employed to give in-situ real time control of the growth process. C1 USA,RES LAB,FT BELVOIR,VA 22060. JA WOOLLAM CO INC,LINCOLN,NE 68508. RP Benson, JD (reprint author), NIGHT VIS & ELECTR SENSORS DIRECTORATE,FT BELVOIR,VA 22060, USA. NR 14 TC 14 Z9 14 U1 0 U2 1 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 420 COMMONWEALTH DR, WARRENDALE, PA 15086 SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 1996 VL 25 IS 8 BP 1406 EP 1410 DI 10.1007/BF02655042 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA VC702 UT WOS:A1996VC70200046 ER PT J AU Leshchinsky, D Leshchinsky, O Ling, HI Gilbert, PA AF Leshchinsky, D Leshchinsky, O Ling, HI Gilbert, PA TI Geosynthetic tubes for confining pressurized slurry: Some design aspects SO JOURNAL OF GEOTECHNICAL ENGINEERING-ASCE LA English DT Article AB This paper deals with geosynthetic tubes that are made of several geosynthetic sheets sewn together to form a shell capable of confining pressurized slurry. The slurry is sufficiently fluid so that it is possible to hydraulically fill the tube. After pumping the slurry in, the geosynthetic shell acts as a ''cheese cloth,'' allowing seepage of liquid out and retaining the solid particles. The availability of a wide selection of geosynthetics in terms of strength, durability, acid permeability enables the use of hydraulically filled tubes in many applications, some of which may be considered critical (e.g., encapsulate contaminated soil). This paper presents an overview of an analysis to calculate both stresses in the geosynthetic and geometry of the tube. It also verifies the correctness and validity of the results obtained from a computer program developed to solve the problem. An instructive parametric study implies that the most critical factor needed to assure successful construction is the pumping pressure; a slight accidental increase in this pressure may result in a very significant stress increase in the encapsulating geosynthetic. Pressure increase beyond a certain level, however, has little influence on the storage capacity of the tube. Guidance in selecting an adequate geosynthetic, including partial safety factors and filtration properties, is also presented. Design aspects associated with required spacing of inlets and head loss of the slurry as it flows through the tube are considered outside the scope of this paper. C1 WIDENER UNIV,DEPT CIVIL ENGN,CHESTER,PA 19013. USA,WATERWAYS EXPT STN,GEOTECH LAB,VICKSBURG,MS 39180. RP Leshchinsky, D (reprint author), UNIV DELAWARE,NEWARK,DE 19716, USA. RI Ling, Hoe/B-1631-2008 NR 15 TC 52 Z9 62 U1 4 U2 10 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9410 J9 J GEOTECH ENG-ASCE JI J. Geotech. Eng.-ASCE PD AUG PY 1996 VL 122 IS 8 BP 682 EP 690 DI 10.1061/(ASCE)0733-9410(1996)122:8(682) PG 9 WC Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA UX993 UT WOS:A1996UX99300010 ER PT J AU Maynord, ST AF Maynord, ST TI Toe-scour estimation in stabilized bendways SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Article ID BENDS AB Minimum bed elevation in stabilized bendways is needed in the design of bank protection. Two empirical methods have been identified for scour-depth estimation that are consistent with available resources on a typical bank-protection project. The 1990 empirical. method by Watanabe, Hasegawa, and Houjyou provided a good fit of the observed data used herein. Maximum depth in the bend is a function of R(c)/W, aspect ratio, channel slope, mean depth, and Darcy friction factor. An empirical scour-depth estimation method is developed herein and presented with a safety factor. Maximum depth in the bend is a function of R(c)/W, aspect ratio, and mean depth. The proposed scour-depth method should be limited to R(c)/W from 1.5 to 10 and W/D-mnc from 20 to 125. Application to overbank flow conditions should be limited to overbank depth less than 20% of main-channel depth. RP Maynord, ST (reprint author), USA,ENGINEER WATERWAYS EXPT STN,HYDR LAB,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 15 TC 6 Z9 6 U1 1 U2 3 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD AUG PY 1996 VL 122 IS 8 BP 460 EP 464 DI 10.1061/(ASCE)0733-9429(1996)122:8(460) PG 5 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA UY472 UT WOS:A1996UY47200007 ER PT J AU Bavari, S Dyas, B Ulrich, RG AF Bavari, S Dyas, B Ulrich, RG TI Superantigen vaccines: A comparative study of genetically attenuated receptor-binding mutants of staphylococcal enterotoxin A SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID TOXIC-SHOCK-SYNDROME; HUMAN T-CELLS; AUREUS; STIMULATION; ACTIVATION; ARTHRITIS; DEATH; MICE AB Superantigens exert their pathologic effects by direct binding to major histocompatibility complex (MHC) class II molecules and T cell antigen receptors (TCR), thus circumventing the normal, antigen-specific immune response. A direct link between disease and toxin suggests an excellent opportunity for vaccine intervention. Site-directed mutants of staphylococcal enterotoxin A (SEA) that have attenuated binding to either the TCR or the MHC class II molecule were developed. Both kinds of SEA mutants induced high levels of antibody against SEA when used as vaccines, and the immunized animals were fully protected when challenged with wild type toxin. However, a residual lethality was associated with the attenuated TCR-binding mutant. These results, combined with an understanding of the molecular nature of superantigen and receptor interactions, indicate that targeting MHC class II binding by site-directed mutagenesis will produce the most effective vaccine. C1 USA,MED RES INST INFECT DIS,DEPT MOLEC BIOL & IMMUNOL,FREDERICK,MD 21702. RP Bavari, S (reprint author), USA,MED RES INST INFECT DIS,DEPT BIOCHEM & CELL BIOL,BLDG 1425,FREDERICK,MD 21702, USA. NR 32 TC 54 Z9 56 U1 1 U2 3 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD AUG PY 1996 VL 174 IS 2 BP 338 EP 345 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA UZ093 UT WOS:A1996UZ09300014 PM 8699064 ER PT J AU Heppner, DG Gordon, DM Gross, M Wellde, B Leitner, W Krzych, U Schneider, I Wirtz, RA Richards, RL Trofa, A Hall, T Sadoff, JC Boerger, P Alving, CR Sylvester, DR Porter, TG Ballou, WR AF Heppner, DG Gordon, DM Gross, M Wellde, B Leitner, W Krzych, U Schneider, I Wirtz, RA Richards, RL Trofa, A Hall, T Sadoff, JC Boerger, P Alving, CR Sylvester, DR Porter, TG Ballou, WR TI Safety, immunogenicity, and efficacy of Plasmodium falciparum repeatless circumsporozoite protein vaccine encapsulated in liposomes SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID T-CELL RESPONSES; MALARIA VACCINE; RECOMBINANT PROTEIN; IMMUNE-RESPONSES; AMINO-ACIDS; LIPID-A; SPOROZOITES; INDUCTION; IMMUNIZATION; EPITOPES AB Seventeen malaria-naive volunteers received a recombinant Plasmodium falciparum vaccine (RLF) containing the carboxy- and the amino-terminal of the circumsporozoite protein (CSP) antigen without the central tetrapeptide repeats. The vaccine was formulated in liposomes with either a low or high dose of 3-deacylated monophosphoryl lipid A (MPL) and administered with alum by intramuscular injection. Both formulations were well tolerated and immunogenic. MPL increased sporozoite antibody titers measured by ELISA, Western blot, and immunofluorescence assay. One high-dose MPL vaccine formulation recipient developed a CSP-specific cytotoxic T lymphocyte response. After homologous sporozoite challenge, immunized volunteers developed patent malaria. There was no correlation between prepatent period and antibody titers to the amino- or carboxyterminal. The absence of delay in patency argues against inclusion of the amino-terminal in future vaccines. A significant cytotoxic T lymphocyte response may have been suppressed by the inclusion of alum as an adjuvant. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT MEMBRANE BIOCHEM,DIV BIOCHEM,WASHINGTON,DC 20307. SMITHKLINE BEECHAM PHARMACEUT,DEPT MOLEC GENET,KING OF PRUSSIA,PA 19406. SMITHKLINE BEECHAM PHARMACEUT,DEPT PROT BIOCHEM,KING OF PRUSSIA,PA 19406. RI Leitner, Wolfgang/F-5741-2011 OI Leitner, Wolfgang/0000-0003-3125-5922 NR 36 TC 68 Z9 70 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD AUG PY 1996 VL 174 IS 2 BP 361 EP 366 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA UZ093 UT WOS:A1996UZ09300017 PM 8699067 ER PT J AU Kiang, JG Koenig, ML AF Kiang, JG Koenig, ML TI Characterization of intracellular calcium pools and their desensitization in thermotolerant human A-431 cells SO JOURNAL OF INVESTIGATIVE MEDICINE LA English DT Article ID C-DEPENDENT PROCESSES; CYTOSOLIC FREE CA2+; HEAT-SHOCK; POLYMORPHONUCLEAR NEUTROPHILS; INOSITOL TRISPHOSPHATE; CA-2+; ACCUMULATION; HYPERTHERMIA; PROTECTION; INDUCTION AB Background: This study characterizes the intracellular Ca2+ pools in nonthermotolerant and thermotolerant human A-431 cells and the reduced cytotoxicity using the inhibitors of Ca2+ mobilizations. Methods: Nonthermotolerant and thermotolerant cells were treated with different Ca2+ mobilizers in the absence of external Ca2+. The cytosolic Ca2+ concentration using fura-2 fluorescence probe was measured to identify the presence of intracellular Ca2+ pools. The cytoxicity of the increase in [Ca2+](i) was studied using the colony forming efficiency assay. Results: The resting intracellular Ca2+ concentration ([Ca2+](i)) in the absence of extracellular Ca2+ was 42 +/- 9 nm, determined by fura-2. Bradykinin (10 mu mol/L), monensin (200 mu mol/L), and ionomycin (1 mu mol/L) sequentially treated to cells mobilized Ca2+ and increased [Ca2+](i) by 64 +/- 23, 40 +/- 6, and 59 +/- 21 nm, respectively. The bradykinin effect was blocked by 5 mu mol/L U-73122 (an inhibitor of inositol trisphosphate production); the ionomycin effect was inhibited by increasing intracellular pH (pH(i)) or treatment with 100 mu mol/L ryanodine while the monensin effect was enhanced by increasing pH(i), but was not inhibited by ryanodine. Cells that were made tolerant to lethal temperatures also responded to bradykinin, monensin, and ionomycin, but the magnitude of the response was diminished. Subsequent treatments with bradykinin, monensin, and ionomycin increased [Ca2+](i) in thermotolerant cells to levels 68 +/- 8, 44 +/- 5, and 45 +/- 5%, respectively, of values found in nonthermotolerant cells. Higher concentrations of these agents did not further increase [Ca2+](i). The bradykinin-induced increase in inositol trisphosphates in thermotolerant cells was also reduced, which perhaps accounts for the attenuation in Ca2+ mobilization. Unlike nonthermotolerant cells, the monensin effect was not enhanced when pH(i) was increased. However, the ionomycin effect was still dependent on pH(i) and was blocked by ryanodine at a higher concentration. Conclusions: These results show that there are bradykinin-, monensin-, and ryanodine-sensitive pools and that thermotolerance attenuates Ca2+ mobilization stimulated by these three agents. Ionomycin at 10 mu mol/L or NaCN at 10 mM for 1 hour demonstrated cytotoxicity. Pretreatment with 100 mu mol/L ryanodine and/or 5 mu mol/L U-73122 reduced cytoxicity produced by either NaCN or ionomycin. These results suggest that an attenuation of [Ca2+](i) increases can diminish cytotoxicity C1 WALTER REED ARMY INST RES,DIV NEUROSCI,DEPT NEUROSCI,WASHINGTON,DC 20307. RP Kiang, JG (reprint author), WALTER REED ARMY INST RES,DIV MED,DEPT CLIN PHYSIOL,BLDG 40,WASHINGTON,DC 20307, USA. NR 35 TC 10 Z9 10 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 1081-5589 J9 J INVEST MED JI J. Invest. Med. PD AUG PY 1996 VL 44 IS 6 BP 352 EP 361 PG 10 WC Medicine, General & Internal; Medicine, Research & Experimental SC General & Internal Medicine; Research & Experimental Medicine GA VE506 UT WOS:A1996VE50600006 PM 8795298 ER PT J AU Marshall, WJ Aldrich, RC Zimmerman, SA AF Marshall, WJ Aldrich, RC Zimmerman, SA TI Laser hazard evaluation method for middle infrared laser systems SO JOURNAL OF LASER APPLICATIONS LA English DT Article DE laser; laser safety; laser safety standard; optical hazards; maximum permissible exposure; eye-safe laser AB Hazard evaluation methods for lasers, with wavelengths greater than 1.4 mu m (mostly in the middle infrared), have changed significantly in the current version of the American National Standard for the Safe Use of Lasers, ANSI 2136.1-1993. A correct evaluation involves comparing the hazard potential based on two evaluation models; one based on individual pulses and the other based on an equivalent continuous-wave exposure. An example of the hazard evaluation method within this spectral region is provided. C1 USN,CTR SURFACE WARFARE,DAHLGREN DIV,DAHLGREN,VA 22448. RP Marshall, WJ (reprint author), USA,CTR HLTH PROMOT & PREVENT MED,ABERDEEN PROVING GROUND,MD 21010, USA. NR 8 TC 11 Z9 11 U1 0 U2 0 PU LASER INST AMER PI ORLANDO PA 12424 RESEARCH PARKWAY SUITE 125, ORLANDO, FL 32826 SN 1042-346X J9 J LASER APPL JI J. Laser Appl. PD AUG PY 1996 VL 8 IS 4 BP 211 EP 216 PG 6 WC Materials Science, Multidisciplinary; Optics; Physics, Applied SC Materials Science; Optics; Physics GA VA291 UT WOS:A1996VA29100008 PM 10160063 ER PT J AU Ahmad, F Razzaghi, M AF Ahmad, F Razzaghi, M TI On the Green-functions technique and phase velocity approximation of axially symmetric fields in stratified media SO JOURNAL OF MATHEMATICAL PHYSICS LA English DT Article ID DISSIPATIVE SLAB; WAVE-EQUATION; POINT-SOURCE; TIME-DOMAIN; INVERSE PROBLEMS; RECONSTRUCTION; SCATTERING AB In this paper a numerical method is developed to solve a one-dimensional inverse scattering problem associated with a pair of two coupled partial differential equations. These equations are for the Green functions that can be used for the optimization of electromagnetic energy within selected regions of a medium in which the propagation is taking place. The method is based upon constructing the Nth degree interpolation polynomial to approximate the Green functions acid the phase velocity function using Legendre-Gauss-Lobatto collocation points. An example is given to demonstrate the accuracy of the developed method. (C) 1996 American Institute of Physics. C1 MISSISSIPPI STATE UNIV, DEPT ELECT & COMP ENGN, MISSISSIPPI STATE, MS 39762 USA. MISSISSIPPI STATE UNIV, DEPT MATH & STAT, MISSISSIPPI STATE, MS 39762 USA. RP Ahmad, F (reprint author), WATERWAYS EXPT STN, VICKSBURG, MS 39180 USA. NR 14 TC 8 Z9 8 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0022-2488 J9 J MATH PHYS JI J. Math. Phys. PD AUG PY 1996 VL 37 IS 8 BP 3824 EP 3832 DI 10.1063/1.531604 PG 9 WC Physics, Mathematical SC Physics GA VA574 UT WOS:A1996VA57400014 ER PT J AU Robbins, RG AF Robbins, RG TI Does Aponomma varanensis (Acari:Ixodida:Ixodidae) occur on the Taiwanese mainland? SO JOURNAL OF PARASITOLOGY LA English DT Article AB On 15 July 1976, teams from the U.S. Naval Medical Research Unit No. 2, Taipei, Taiwan, made 3 collections of ticks from beneath the dorsal scales of the Taiwan stink snake, Elaphe carinata, at Makung in the Penghu Islands, which lie astride the Tropic of Cancer in the Taiwan Strait between southern mainland China and Taiwan proper. These ticks were later determined to be Aponomma varanensis (Supine, 1897), but this discovery was never published, and no member of the genus Aponomma has heretofore been reported from Taiwan or any of its outlying islets. Because suitable hosts, including E. carinata, are abundant on Taiwan and because A, varanensis is widely distributed in tropical Asia, it is argued that this or a related species of Aponomma will one day be found on the Taiwanese mainland. RP Robbins, RG (reprint author), WALTER REED ARMY MED CTR, ARMED FORCES PEST MANAGEMENT BOARD, WASHINGTON, DC 20307 USA. NR 19 TC 5 Z9 6 U1 0 U2 0 PU AMER SOC PARASITOLOGISTS PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0022-3395 EI 1937-2345 J9 J PARASITOL JI J. Parasitol. PD AUG PY 1996 VL 82 IS 4 BP 672 EP 673 DI 10.2307/3283805 PG 2 WC Parasitology SC Parasitology GA VC057 UT WOS:A1996VC05700031 PM 8691388 ER PT J AU Raszka, WV Moriarty, RA Ottolini, MG Waecker, NJ Ascher, DP Cieslak, TJ Fischer, GW Robb, ML AF Raszka, WV Moriarty, RA Ottolini, MG Waecker, NJ Ascher, DP Cieslak, TJ Fischer, GW Robb, ML TI Delayed-type hypersensitivity skin testing in human immunodeficiency virus-infected pediatric patients SO JOURNAL OF PEDIATRICS LA English DT Article ID BETA-2-MICROGLOBULIN LEVEL; CHILDREN; PROGRESSION; PROGNOSIS; DISEASE; ANERGY; MEN AB Objective: To evaluate whether pediatric patients infected with human immunodeficiency virus (HIV) can mount appropriate delayed-type hypersensitivity (DTH) skin responses to recall antigens and whether these responses can be correlated with clinical or immunologic parameters. Design: Prospective evaluation of DTH responses in HIV-infected children. Uninfected children born to HIV-infected mothers served as control subjects. Antigens used for yearly DTH testing included Candida albicans (1:100, 1:10); mumps virus; Trichophyton; purified protein derivative of tuberculin; and tetanus toroid (1:100, 1:10). At the time of each DTH test, patients were staged according to two Centers for Disease Control and Prevention pediatric HIV classification systems, and T-cell subsets were obtained. Results: Twenty-seven HIV-infected patients with a median age at entry of 74.1 (range, 12 to 156) months were followed. Forty-four DTH skin tests in 21 symptom-free HIV-infected patients (Pt) and 18 tests in 10 HIV-infected patients with symptoms (P2), as well as 43 DTH skin tests in 18 patients who had either mild or moderate clinical symptoms or immunosuppression and 19 tests in 13 patients with severe symptoms or immunosuppression, were evaluated. Sixteen DTH skin tests were performed in 14 uninfected patients. HIV-infected patients tended to have fewer DTH responses to antigens and of smaller size than did uninfected patients. When controlled for age, few differences in DTH responsiveness were seen between HIV-infected and uninfected patients. Anergy was associated with symptomatic disease, evidence of advanced clinical or immunologic disease, and low CD4(+) percentages (p < 0.05). Conclusions: HIV-infected children are able to mount antigen-specific cell-mediated immune responses that are qualitatively similar to those of age-matched control subjects. Loss of DTH responsiveness correlates with both clinical and immunologic evidence of HIV disease progression. C1 NATL NAVAL MED CTR, DEPT PEDIAT, BETHESDA, MD USA. USN, MED CTR, DEPT PEDIAT, SAN DIEGO, CA 92152 USA. WILFORD HALL USAF MED CTR, DEPT PEDIAT, SAN ANTONIO, TX 78236 USA. WALTER REED ARMY INST RES, DIV RETROVIRAL RES, ROCKVILLE, MD USA. RP Raszka, WV (reprint author), UNIFORMED SERV UNIV HLTH SCI, DEPT PEDIAT, BETHESDA, MD 20814 USA. NR 25 TC 22 Z9 22 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD AUG PY 1996 VL 129 IS 2 BP 245 EP 250 DI 10.1016/S0022-3476(96)70249-4 PG 6 WC Pediatrics SC Pediatrics GA VK797 UT WOS:A1996VK79700010 PM 8765622 ER PT J AU Parker, AP Underwood, JH AF Parker, AP Underwood, JH TI Stress intensity, stress concentration, and fatigue crack growth along evacuator holes of pressurized, autofrettaged tubes SO JOURNAL OF PRESSURE VESSEL TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article AB The geometry analyzed consists of a thick-walled cylinder having a small-diameter evacuator hole penetrating radially through the wall. The loading involves pressure acting on the i.d, of the tube and all or part of this pressure acting on the evacuator hole. In addition, the tube may be fully or partially autofrettaged. Total hoop stress concentrations are determined for a range of radial locations along the evacuator, as are stress intensity factors along a crack emanating from the evacuator hole. Fatigue crack growth rates, and hence crack profiles, are predicted at each of the radial locations. These predictions indicate that the critical location for the crack in a nonautofrettaged tube is at the i.d., whereas in a fully autofrettaged tube it is located approximately halfway through the wall thickness. Taking account of the influence of stress ratio, sigma(min)/sigma(max), has a significant influence an crack shape in autofrettaged tubes, but a limited effect upon lifetime. The effect upon fatigue lifetime of axial residual stresses due to the autofrettage process is described and it is demonstrated that an insignificant reduction in lifetime results from the presence of such stresses. Finally the predicted profiles are compared with experimental observations of fatigue cracked evacuator holes and a limited comparison of predicted and actual lifetimes is presented. Agreement is considered good. C1 USA,ARMAMENT RES DEV & ENGN CTR,WATERVLIET,NY 12189. RP Parker, AP (reprint author), CRANFIELD UNIV,ROYAL MIL COLL SCI,SHRIVENHAM SN6 8LA,ENGLAND. NR 11 TC 2 Z9 2 U1 0 U2 0 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0094-9930 J9 J PRESS VESS-T ASME JI J. Press. Vessel Technol.-Trans. ASME PD AUG PY 1996 VL 118 IS 3 BP 336 EP 342 DI 10.1115/1.2842197 PG 7 WC Engineering, Mechanical SC Engineering GA VD533 UT WOS:A1996VD53300010 ER PT J AU Rubes, RH Jaconette, RL AF Rubes, RH Jaconette, RL TI Continuum of care controversy SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY LA English DT Letter C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. RP Rubes, RH (reprint author), BLANCHFIELD ARMY COMMUNITY HOSP,FT CAMPBELL,KY, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0890-8567 J9 J AM ACAD CHILD PSY JI J. Am. Acad. Child Adolesc. Psychiatr. PD AUG PY 1996 VL 35 IS 8 BP 973 EP 973 DI 10.1097/00004583-199608000-00001 PG 1 WC Psychology, Developmental; Pediatrics; Psychiatry SC Psychology; Pediatrics; Psychiatry GA UY926 UT WOS:A1996UY92600001 PM 8755789 ER PT J AU Frishberg, DP Sperling, LC Guthrie, VM AF Frishberg, DP Sperling, LC Guthrie, VM TI Transverse scalp sections: A proposed method for laboratory processing SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID SCARRING ALOPECIA; BIOPSY SPECIMENS AB Background: Transverse sections of human scalp biopsy specimens can provide both qualitative and quantitative information about follicular histopathology not readily available in vertically sectioned specimens. Objective: We propose a method for making the processing and interpretation of such specimens easier. Methods: All scalp biopsy specimens obtained during the past 18 months in our institution for the evaluation of alopecia were processed for transverse sections by means of a technique employing trisection or quadrisection (rather than the standard bisection), and maintaining all sections in the same anatomic orientation (deep to superficial) in all tissue pieces on microscopic slides. Results: More than 120 transversely sectioned specimens from more than 75 patients have been processed with this technique. The typical number of slides cut per specimen decreased from between 12 and 20 to between 1 and 4, with no loss of clinical information. Conclusion: This technique allows transverse sections for evaluation of alopecia to be processed in a more cost-effective manner and compares favorably with previously published techniques in providing diagnostic information. RP Frishberg, DP (reprint author), WALTER REED ARMY MED CTR,SERV ANAT PATHOL,T-2 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 6 TC 33 Z9 37 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD AUG PY 1996 VL 35 IS 2 BP 220 EP 222 DI 10.1016/S0190-9622(96)90328-X PN 1 PG 3 WC Dermatology SC Dermatology GA VA757 UT WOS:A1996VA75700012 PM 8708025 ER PT J AU Welch, ML Anderson, LL Grabski, WJ AF Welch, ML Anderson, LL Grabski, WJ TI Surgical pearl: Suturing - Control and conservation SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article RP Welch, ML (reprint author), BROOKE ARMY MED CTR,DERMATOL SERV,SAN ANTONIO,TX, USA. NR 3 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD AUG PY 1996 VL 35 IS 2 BP 243 EP 244 DI 10.1016/S0190-9622(96)90330-8 PN 1 PG 2 WC Dermatology SC Dermatology GA VA757 UT WOS:A1996VA75700014 PM 8708027 ER PT J AU Cameron, SM Whitlock, WL Tabor, MS AF Cameron, SM Whitlock, WL Tabor, MS TI Foreign body aspiration in dentistry: A review SO JOURNAL OF THE AMERICAN DENTAL ASSOCIATION LA English DT Review AB This article reviews the dangers of aspirating foreign bodies of dental origin. Two illustrative cases are presented, including an unusual case involving aspiration of an elastomeric impression material. The authors describe the techniques used to identify the foreign body. A radiodensimetric study of four impression materials demonstrates the difficulty of identifying most impression materials. the authors also present some strategies for reducing the risk of aspiration during dental procedures. C1 USA,DWIGHT D EISENHOWER MED CTR,FT GORDON,GA 30905. MED UNIV S CAROLINA,SCH DENT,DEPT ORAL & MAXILLOFACIAL SURG,CHARLESTON,SC 29425. NR 31 TC 35 Z9 35 U1 0 U2 0 PU AMER DENTAL ASSN PI CHICAGO PA 211 E CHICAGO AVE, CHICAGO, IL 60611 SN 0002-8177 J9 J AM DENT ASSOC JI J. Am. Dent. Assoc. PD AUG PY 1996 VL 127 IS 8 BP 1224 EP 1229 PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA VB734 UT WOS:A1996VB73400024 PM 8803399 ER PT J AU Warber, JP Haddad, EH Hodgkin, GE Lee, JW AF Warber, JP Haddad, EH Hodgkin, GE Lee, JW TI Foodservice specialists exhibit lack of knowledge in identifying whole-grain products SO JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION LA English DT Article C1 LOMA LINDA UNIV,SCH PUBL HLTH,DEPT NUTR,LOMA LINDA,CA 92350. LOMA LINDA UNIV,SCH PUBL HLTH,DEPT HLTH PROMOT & HLTH EDUC,LOMA LINDA,CA 92350. RP Warber, JP (reprint author), USA,ENVIRONM MED RES INST,MIL NUTR DIV,426 KANSAS ST,NATICK,MA 01760, USA. NR 17 TC 9 Z9 10 U1 0 U2 0 PU AMER DIETETIC ASSN PI CHICAGO PA 216 W JACKSON BLVD #800, CHICAGO, IL 60606-6995 SN 0002-8223 J9 J AM DIET ASSOC JI J. Am. Diet. Assoc. PD AUG PY 1996 VL 96 IS 8 BP 796 EP 798 PG 3 WC Nutrition & Dietetics SC Nutrition & Dietetics GA VF445 UT WOS:A1996VF44500029 PM 8683013 ER PT J AU Flemish, JR Xie, K AF Flemish, JR Xie, K TI Profile and morphology control during etching of SiC using electron cyclotron resonant plasmas SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID FLUORINATED PLASMAS; SILICON-CARBIDE; ION AB The profiles and surface morphologies of etched SiC can be effectively controlled using electron cyclotron resonant plasmas. When high bias (100 V) Is applied to the substrate, etching is anisotropic and smooth surfaces result, with the exception of trenches which form at the base of the sidewall features. In contrast, etching at low bias (8 V) is more isotropic ic with no apparent trenching, but results in textured etched surfaces and jagged sidewall features. However, the etch surfaces and sidewall features call be smoothed by subjecting the samples to a high bias pretreatment prior to etching at lower bias. Etching isotropy is strongly dependent on both the applied bias and the proximity of the sample to the ECR source. A combination of high and low bias etching has been employed for micromachining cantilever structures from single-crystal SiC. C1 USA,RES LAB,PHYS SCI DIRECTORATE,AMSRL,PS,DB,FT MONMOUTH,NJ 07703. NR 11 TC 35 Z9 35 U1 1 U2 5 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD AUG PY 1996 VL 143 IS 8 BP 2620 EP 2623 DI 10.1149/1.1837058 PG 4 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA VC706 UT WOS:A1996VC70600044 ER PT J AU Lee, JW Pearton, SJ Abernathy, CR Zavada, JM Chai, BLH AF Lee, JW Pearton, SJ Abernathy, CR Zavada, JM Chai, BLH TI Wet and dry etching of LiGaO2 and LiAlO2 SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Letter ID MOLECULAR-BEAM EPITAXY; BUFFER LAYER; GAN; GROWTH; SAPPHIRE; SUBSTRATE AB LiGaO2 and LiAlO2 have similar lattice constants to GaN, and may prove useful as substrates for III-nitride epitaxy. We have found that these materials may be wet chemically etched in some acid solutions, including HF, at rates between 150 and 40,000 Angstrom/min. Dry etching with SF6/Ar plasmas provides faster rates than Cl-2/Ar or CH4/H-2/Ar under electron cyclotron resonance conditions, indicating the fluoride etch products are more volatile that their chloride or metallorganic/hydride counterparts. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. UNIV CENT FLORIDA,CTR RES ELECTROOPT & LASERS,ORLANDO,FL 32816. RP Lee, JW (reprint author), UNIV FLORIDA,DEPT MAT SCI & ENGN,GAINESVILLE,FL 32611, USA. NR 21 TC 5 Z9 5 U1 0 U2 1 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD AUG PY 1996 VL 143 IS 8 BP L169 EP L171 DI 10.1149/1.1837018 PG 3 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA VC706 UT WOS:A1996VC70600004 ER PT J AU Shitzer, A Stroschein, LA Gonzalez, RR Pandolf, KB AF Shitzer, A Stroschein, LA Gonzalez, RR Pandolf, KB TI Application of a lumped-parameter heat exchange model to cold-induced temperature and blood flow measurements in the finger-tip SO JOURNAL OF THERMAL BIOLOGY LA English DT Article DE plethysmograph; pulse volume; model; thermal response; heat exchange ID CIRCULATION PATTERN; UPPER EXTREMITIES; DEPENDENCE AB Measured cold induced vasodilatation (CIVD) temperature and pulse volume changes were used to validate a lumped-parameter heat exchange model of the finger-tip. The simultaneously measured data were extracted from a previous study by Blaisdell (1951). Finger-tip temperatures were estimated using adjusted blood perfusion data as an input. The model was also applied to the inverse problem, namely, to estimate blood perfusion from measured temperatures. A three-segment arterial blood supply temperature profile, composed of an exponential drop followed by a levelling-off and succeeded by an exponential rise, was assumed in order to improve the predictions of the model. Comparison of temperature records showed good conformity, with the estimated values generally under predicting the measured ones. The quality of the predictions of the inverse problem was not as good with local values amounting to less than half the measured ones. In particular the model was shown to retain the basic features of the thermal responses of the cold-stressed extremity, i.e. shape of the curves and the delayed rise of temperature in relation to blood perfusion. Published by Elsevier Science Ltd. C1 USA, ENVIRONM MED RES INST, ENVIRONM PHYSIOL & MED DIRECTORATE, NATICK, MA 01760 USA. RP Shitzer, A (reprint author), TECHNION ISRAEL INST TECHNOL, DEPT MECH ENGN, IL-32000 HAIFA, ISRAEL. NR 21 TC 3 Z9 3 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4565 J9 J THERM BIOL JI J. Therm. Biol. PD AUG PY 1996 VL 21 IS 4 BP 213 EP 220 DI 10.1016/0306-4565(96)00003-4 PG 8 WC Biology; Zoology SC Life Sciences & Biomedicine - Other Topics; Zoology GA VD929 UT WOS:A1996VD92900002 ER PT J AU Rushton, HG Belman, AB Zaontz, MR Skoog, SJ Sihelnik, S AF Rushton, HG Belman, AB Zaontz, MR Skoog, SJ Sihelnik, S TI The influence of small functional bladder capacity and other predictors on the response to desmopressin in the management of monosymptomatic nocturnal enuresis SO JOURNAL OF UROLOGY LA English DT Article; Proceedings Paper CT Annual Meeting of the Section on Urology, American-Academy-of-Pediatrics CY OCT 14-16, 1995 CL SAN FRANCISCO, CA SP Amer Acad Pediat, Sect Urol DE bladder; enuresis; desmopressin ID ENURETIC CHILDREN; URODYNAMICS; FLOW; AGE AB Purpose: The relationship of functional bladder capacity as well as other variables to the responsiveness to desmopressin in children with monosymptomatic nocturnal enuresis was investigated. Materials and Methods: A total of 95 children 8 to 14 years old with monosymptomatic nocturnal enuresis (6 or more of 14 nights wet) were evaluated in a double-blind study followed by open label crossover extension using 20 to 40 mcg. desmopressin. Evaluated predictors of response included patient age, gender, race, family history, number of baseline wet nights, urine osmolality parameters and maximum functional bladder capacity (as a percent of predicted bladder capacity based on the formula, patient age + 2 x 30 = cc). Responders to desmopressin were classified as excellent (2 or less of 14 nights wet) or good (50% or greater decrease but more than 2 of 14 nights wet) and nonresponders were defined by a less than 50% decrease in wet nights. Results: Of the 95 patients 25 (29.5%) achieved an excellent response to desmopressin and 18 (18.9%) had a good response for a cumulative response rate of 45.3%. The remaining 52 patients (54.7%) were nonresponders. There were no significant differences between responders and nonresponders in regard to gender, race, positive family history or baseline urine osmolality parameters. Response to desmopressin was associated with older age, fewer baseline wet nights and larger bladder capacity. Patients with a functional bladder capacity greater than 70% predicted bladder capacity were 2 times more likely to respond to desmopressin. Conclusions: The responsiveness of children with nocturnal enuresis to desmopressin is adversely affected by reduced functional bladder capacity. The results of this study have implications regarding the potential use of combination pharmacotherapy with desmopressin and an anticholinergic for enuretic patients who are nonresponsive to single drug therapy. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. COOPER HOSP UNIV MED CTR,CHILDRENS REG HOSP,CAMDEN,NJ. RP Rushton, HG (reprint author), CHILDRENS NATL MED CTR,111 MICHIGAN AVE NW,WASHINGTON,DC 20010, USA. NR 31 TC 86 Z9 91 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD AUG PY 1996 VL 156 IS 2 BP 651 EP 655 DI 10.1016/S0022-5347(01)65775-6 PN 2 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA UX153 UT WOS:A1996UX15300022 PM 8683752 ER PT J AU Ludwig, GV Kondig, JP Smith, JF AF Ludwig, GV Kondig, JP Smith, JF TI A putative receptor for venezuelan equine encephalitis virus from mosquito cells SO JOURNAL OF VIROLOGY LA English DT Article ID SINDBIS VIRUS; LAMININ RECEPTOR; ENCEPHALOMYELITIS VIRUS; ATTENUATING MUTATIONS; MEDIATED ACTIVATION; ELASTIN RECEPTOR; MAMMALIAN-CELLS; CDNA CLONE; BINDING; INFECTION AB We have identified a cellular protein from a continuous mosquito cell line (C6/36) that appears to play a significant role in the attachment of Venezuelan equine encephalitis (VEE) virus to these cells. VEE virus bound to a 32-kDa polypeptide present in the C6/36 plasma membrane fraction, and binding to this polypeptide was dose dependent and saturable and competed with homologous and heterologous alphaviruses, These observations suggest that this polypeptide binds virus via a receptor-ligand interaction, The 32-kDa polypeptide was expressed on the surfaces of C6/36 cells, and monoclonal antibodies directed against either this cell polypeptide or the VEE virus E2 glycoprotein, which is thought to be the viral attachment protein, interfered with virus attachment, Collectively, these data provide evidence suggesting that the 32-kDa polypeptide serves as a receptor for VEE virus infection of cells. We have characterized this cell polypeptide as a laminin-binding protein on the basis of its ability to interact directly with laminin as well as its immunologic cross-reactivity with the high-affinity human laminin receptor. RP Ludwig, GV (reprint author), USA,MED RES INST INFECT DIS,DIV VIROL,FT DETRICK,MD 21702, USA. NR 44 TC 93 Z9 98 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD AUG PY 1996 VL 70 IS 8 BP 5592 EP 5599 PG 8 WC Virology SC Virology GA UX582 UT WOS:A1996UX58200084 PM 8764073 ER PT J AU Cowan, DN Jones, BH Frykman, PN Polly, DW Harman, EA Rosenstein, RM Rosenstein, MT AF Cowan, DN Jones, BH Frykman, PN Polly, DW Harman, EA Rosenstein, RM Rosenstein, MT TI Lower limb morphology and risk of overuse injury among male infantry trainees SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE epidemiology; exercise; risk factors; overuse injuries; stress fractures; valgus; varus; Q-angle; leg length discrepancy ID EXERCISE; ARMY AB The effect of anatomic variation on the risk of overuse injuries has not been adequately evaluated. To determine the association of several common anatomic characteristics (gem varum, genu valgum, genu recurvatum, and lower limb length differences) with risk of overuse injury, we made prospective morphologic measurements of young men prior to beginning 12 wk of Army infantry training. The training included frequent running, marching, calisthenics, and other vigorous activities. Lower extremity anatomic landmarks were highlighted, and front- and side-view photographic slides were taken of the 294 study volunteers. The slides were computer digitized, and the following measures calculated: pelvic width to knee width ratio (to assess genu valgum/varum), quadriceps angle (Q-angle), knee angle at full extension, and lower limb length differences. The cumulative incidence of lower limb overuse injury was 30%. Relative risk (RR) of overuse injury was significantly higher among participants with the most valgus knees (RR = 1.9). Those with Q-angle of more than 15 degrees had significantly increased risk specifically for stress fractures (RR = 5.4). Anatomic characteristics were associated with several other types of injuries, including pain and nonacute muscle strain due to overuse. This pilot study provides evidence that some lower limb morphologic characteristics may place individuals at increased risk of overuse injuries. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. USA,CTR HLTH PROMOT & PREVENT MED,ABERDEEN PROVING GROUND,MD. USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 27 TC 76 Z9 80 U1 2 U2 13 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD AUG PY 1996 VL 28 IS 8 BP 945 EP 952 DI 10.1097/00005768-199608000-00002 PG 8 WC Sport Sciences SC Sport Sciences GA VC749 UT WOS:A1996VC74900002 PM 8871902 ER PT J AU Morgan, TO Jacobsen, SJ McCarthy, WF Jacobson, DJ McLeod, DG Moul, JW AF Morgan, TO Jacobsen, SJ McCarthy, WF Jacobson, DJ McLeod, DG Moul, JW TI Age-specific reference ranges for serum prostate-specific antigen in black men SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID CANCER; ADENOCARCINOMA; CARCINOMA AB Background The detection of prostate cancer by screening for prostate-specific antigen (PSA) in serum is improved when age-specific reference ranges are used, but these ranges have been derived from white populations. We determined the distribution of PSA and age-specific reference ranges in black men both with and without prostate cancer. Methods From January 1991 through May 1995, we measured serum PSA in 3475 men with no clinical evidence of prostate cancer (1802 white and 1673 black) and 1783 men with prostate cancer (1372 white and 411 black). We studied the data asa function of age and race to determine the usefulness of measuring PSA in diagnosing prostate cancer. Results Serum PSA concentrations in black men (geometric mean in controls, 1.48 ng per milliliter; in patients, 7.46) were significantly higher than those in white men (geometric mean in controls, 1.33 ng per milliliter; in patients, 6.28). The values in the controls correlated directly with age. The area under the receiver-operating-characteristic curve was 0.91 for blacks and 0.94 for whites. If traditional age-specific reference ranges were used in screening black men, with the test specificity kept at 95 percent, 41 percent of cases of prostate cancer would be missed. For the test to have 95 percent sensitivity among black men, the following normal reference ranges should be used: for men in their 40s, 0 to 2.0 ng of PSA per milliliter (test specificity, 93 percent); for men in their 50s, 0 to 4.0 ng per milliliter (specificity, 88 percent); for men in their 60s, 0 to 4.5 ng per milliliter (specificity, 81 percent); and for men in their 70s, 0 to 5.5 ng per milliliter (specificity, 78 percent). Conclusions Serum PSA concentrations can be used to discriminate between men with prostate cancer and those without it among both blacks and whites. Over 40 percent of cases of prostate cancer in black men would not be detected by tests using traditional age-specific reference ranges, which maintain specificity at 95 percent. In this high-risk population, the alternative approach - maintaining sensitivity at 95 percent - may be used with acceptable decrements in specificity. (C) 1996, Massachusetts Medical Society. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT SURG,UROL SERV,WASHINGTON,DC 20307. MAYO CLIN & MAYO FDN,DEPT HLTH SCI RES,CLIN EPIDEMIOL SECT,ROCHESTER,MN 55905. MAYO CLIN & MAYO FDN,DEPT HLTH SCI RES,BIOSTAT SECT,ROCHESTER,MN 55905. UNIFORMED SERV UNIV HLTH SCI,CTR PROSTATE DIS RES,BETHESDA,MD 20814. NR 21 TC 282 Z9 292 U1 0 U2 1 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD AUG 1 PY 1996 VL 335 IS 5 BP 304 EP 310 DI 10.1056/NEJM199608013350502 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA UY982 UT WOS:A1996UY98200002 PM 8663870 ER PT J AU Kinser, JM Johnson, JL AF Kinser, JM Johnson, JL TI Stabilized input with a feedback pulse-coupled neural network SO OPTICAL ENGINEERING LA English DT Article DE optical neural networks; pulse-coupled neural networks; inhibitory feedback AB Biological findings in the visual cortex of some small mammals are combined with the increasing evidence of feedback from the brain to the sensors to create a feedback pulse-coupled neural network. The main advantage of this algorithm is that it extracts portions of the input information with each iteration. The input is eventually altered to a steady-state output. However, during transition the input al different iterations presents primitive information of the input. (C) 1996 Society of Photo-Optical Instrumentation Engineers. C1 USA,MISSILE COMMAND,AMSMI,RD,WS,PO,REDSTONE ARSENAL,AL 35898. RP Kinser, JM (reprint author), ALABAMA A&M UNIV,CTR APPL OPT SCI,DEPT PHYS,POB 1268,NORMAL,AL 35762, USA. NR 5 TC 14 Z9 15 U1 0 U2 2 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD AUG PY 1996 VL 35 IS 8 BP 2158 EP 2161 DI 10.1117/1.600797 PG 4 WC Optics SC Optics GA VD091 UT WOS:A1996VD09100008 ER PT J AU Li, CT Lu, MZ Yin, SZ Yu, FTS Hudson, TD McMillen, DK AF Li, CT Lu, MZ Yin, SZ Yu, FTS Hudson, TD McMillen, DK TI Performance of quantized composite filters in a joint transform correlator SO OPTICAL ENGINEERING LA English DT Article DE optical neural networks; quantized composite filters; simulated annealing; joint transform correlators ID SIMULATED ANNEALING ALGORITHM; BINARY PHASE; DISCRIMINANT AB The use of a simulated annealing algorithm to design quantized composite reference function (QGRF) filters is presented. Since the QCRF filters are spatial domain filters using finite quantization levels, they can be implemented al the output spatial light modulator of a joint transform correlator. The performance of the QCRF fillers has been tested, in which we have shown that the detectability, accuracy, discriminability, and reliability improve as the quantization of the filter increases. (C) 1996 Society of Photo-Optical Instrumentation Engineers. C1 USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898. RP Li, CT (reprint author), PENN STATE UNIV,DEPT ELECT ENGN,UNIVERSITY PK,PA 16802, USA. NR 15 TC 8 Z9 8 U1 0 U2 0 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD AUG PY 1996 VL 35 IS 8 BP 2218 EP 2226 DI 10.1117/1.600829 PG 9 WC Optics SC Optics GA VD091 UT WOS:A1996VD09100017 ER PT J AU Lallement, G Shih, TM PernotMarino, I Baubichon, D Foquin, A McDonough, JH AF Lallement, G Shih, TM PernotMarino, I Baubichon, D Foquin, A McDonough, JH TI The role of nitric oxide in soman-induced seizures, neuropathology, and lethality SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE soman; seizures; nitric oxide; glyceryl trinitrate; nitric oxide synthase inhibitors ID ACID-INDUCED SEIZURES; DEEP PREPIRIFORM CORTEX; CEREBRAL BLOOD-FLOW; L-ARGININE; NO SYNTHASE; GLYCERYL TRINITRATE; TIME-COURSE; RAT-BRAIN; INHIBITION; ACETYLCHOLINE AB The effects of the inhibitors of endothelial and neuronal nitric oxide (NO) synthases, N-nitro-L-arginine methyl ester (L-NAME) and 7-nitroindazole (7-NI), respectively, and the precursor of NO, glyceryl trinitrate, on soman-induced seizures, lethality, and neuropathology were studied in rats. It was found that pretreatment of rats with L-NAME and 7-NI potentiated the severity of motor convulsions and enhanced lethality produced by soman. On the other hand, glyceryl trinitrate, administered transdermally at doses ranging from 2.5-5 mg/day 1 day before soman, decreased seizure susceptibility and lethality in soman intoxicated animals. This was accompanied by a subsequent reduction of central neuronal damage 24 h after soman treatment. Pretreatment with glyceryl trinitrate also reversed seizure latency produced by 7-NI treatment during soman intoxication. These results indicate that neuronal NO may play a prominent role in seizures by acting as an anticonvulsant and neuroprotectant in soman intoxication. C1 USA, MED RES INST CHEM DEF, DIV PHARMACOL, ABERDEEN PROVING GROUND, MD 21010 USA. RP Lallement, G (reprint author), SERV SANTE ARMEES, CTR RECH, UNITE NEUROTOXICOL, BP 87, F-38702 LA TRONCHE, FRANCE. NR 36 TC 30 Z9 31 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD AUG PY 1996 VL 54 IS 4 BP 731 EP 737 DI 10.1016/0091-3057(95)02223-6 PG 7 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA VA074 UT WOS:A1996VA07400015 PM 8853197 ER PT J AU Sun, SN Kioussis, N Ciftan, M AF Sun, SN Kioussis, N Ciftan, M TI First-principles determination of the effects of boron and sulfur on the ideal cleavage fracture in Ni3Al SO PHYSICAL REVIEW B LA English DT Article ID GRAIN-BOUNDARY COHESION; SINGLE-CRYSTALS; SEGREGATION; BEHAVIOR; ALLOYS AB The effects of boron and sulfur impurities on the ideal cleavage fracture properties of Ni3Al under tensile stress are investigated using the full-potential linear-muffin-tin-orbital total-energy method, with a repeated slab arrangement of atoms simulating an isolated cleavage plane. Results for the stress-strain relationship, ideal cleavage energies, ideal yield stress and strains with and without impurities are presented, and the electronic mechanism underlying the contrasting effects of boron and sulfur impurities on the ideal cleavage of Ni3Al is elucidated. C1 USA,RES OFF,DIV PHYS,RES TRIANGLE PK,NC 27709. RP Sun, SN (reprint author), CALIF STATE UNIV NORTHRIDGE,DEPT PHYS & ASTRON,NORTHRIDGE,CA 91330, USA. NR 26 TC 21 Z9 21 U1 0 U2 2 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD AUG 1 PY 1996 VL 54 IS 5 BP 3074 EP 3078 DI 10.1103/PhysRevB.54.3074 PG 5 WC Physics, Condensed Matter SC Physics GA VC596 UT WOS:A1996VC59600030 ER PT J AU Bao, W Broholm, C Honig, JM Metcalf, P Trevino, SF AF Bao, W Broholm, C Honig, JM Metcalf, P Trevino, SF TI Itinerant antiferromagnetism in the Mott compound V1.973O3 SO PHYSICAL REVIEW B LA English DT Article ID SPIN-DENSITY-WAVE; ELECTRON FERROMAGNETISM; MAGNETIC FLUCTUATIONS; QUANTITATIVE ASPECTS; NEUTRON-SCATTERING; TEMPERATURE; NICKEL; SUPERCONDUCTIVITY; EXCITATIONS; DEPENDENCE AB The doping-induced metallic state of the Mott system V2-yO3 has spin-density-wave order for T centered at each antiferromagnetic Bragg point. The q, omega. and T dependence of magnetic fluctuations can be described by the self-consistent renormalization theory for weak itinerant antiferromagnets developed by Moriya, Hasegawa, and Nakayama. Thermodynamic properties below similar to 10T(N) are quantitatively accounted for by this theory in its simplest form with only four parameters, which are determined by our neutron-scattering experiment. C1 JOHNS HOPKINS UNIV,BALTIMORE,MD 21218. NATL INST STAND & TECHNOL,GAITHERSBURG,MD 20899. PURDUE UNIV,W LAFAYETTE,IN 47907. USA,RES LAB,ADELPHI,MD 20783. RP Bao, W (reprint author), BROOKHAVEN NATL LAB,UPTON,NY 11973, USA. RI Broholm, Collin/E-8228-2011; Bao, Wei/E-9988-2011 OI Broholm, Collin/0000-0002-1569-9892; Bao, Wei/0000-0002-2105-461X NR 38 TC 25 Z9 25 U1 0 U2 4 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD AUG 1 PY 1996 VL 54 IS 6 BP R3726 EP R3729 PG 4 WC Physics, Condensed Matter SC Physics GA VD677 UT WOS:A1996VD67700015 ER PT J AU Sirenko, YM Stroscio, MA Kim, KW AF Sirenko, YM Stroscio, MA Kim, KW TI Dynamics of cytoskeletal filaments SO PHYSICAL REVIEW E LA English DT Article ID CYLINDRICAL QUANTUM WIRES; PHONON SCATTERING RATES; F-ACTIN MODEL; THERMAL FLUCTUATIONS; FLEXURAL RIGIDITY; CARBON NANOTUBES; MYOSIN-FILAMENTS; MICROTUBULES; ELECTRON; FLEXIBILITY AB We apply elasticity theory formalism to study long-range, collective vibrations of actin and intermediate filaments, which are long cylindrical macromolecules and constitute part of the cytoskeleton network in eukariotic cells. The dispersion relations are obtained for elastic waves propagating in the vicinity of filaments which are modeled as elastic cylindrical rods immersed in a liquid. In the long-wavelength limit the filament-water system supports two acoustic modes with propagation speeds of approximately 800 and 1300 m/s and a single flexural wave with parabolic dispersion law. The presence of solvent leads to radiation of acoustic energy from waves with a phase velocity exceeding the speed of sound of water. Our study complements the existing normal-mode analysis of free actin filament vibrations and generalizes these results for different structures as well as including the effects of solvents. C1 USA, RES OFF, RES TRIANGLE PK, NC 27709 USA. RP N CAROLINA STATE UNIV, DEPT ELECT & COMP ENGN, HIGH FREQUENCY ELECT LAB, RALEIGH, NC 27695 USA. NR 61 TC 11 Z9 12 U1 0 U2 3 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2470-0045 EI 2470-0053 J9 PHYS REV E JI Phys. Rev. E PD AUG PY 1996 VL 54 IS 2 BP 1816 EP 1823 DI 10.1103/PhysRevE.54.1816 PG 8 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA VD674 UT WOS:A1996VD67400107 ER PT J AU Scalora, M Flynn, RJ Reinhardt, SB Fork, RL Bloemer, MJ Tocci, MD Bowden, CM Ledbetter, HS Bendickson, JM Dowling, JP Leavitt, RP AF Scalora, M Flynn, RJ Reinhardt, SB Fork, RL Bloemer, MJ Tocci, MD Bowden, CM Ledbetter, HS Bendickson, JM Dowling, JP Leavitt, RP TI Ultrashort pulse propagation at the photonic band edge: Large tunable group delay with minimal distortion and loss SO PHYSICAL REVIEW E LA English DT Article ID TIMES; GAP AB We examine optical pulse propagation through a 30-period, GaAs/AlAs, one-dimensional, periodic structure at the photonic band-edge transmission resonance. We predict theoretically-and demonstrate experimentally-an approximate energy, momentum, and form invariance of the transmitted pulse, as well as large group index (up to 13.5). The group index is tunable and many orders of magnitude more sensitive to variation in material refractive index than for bulk material. We interpret this observation in terms of time-dependent electromagnetic states of the pulse-crystal system. C1 USA,MISSILE COMMAND,WEAPONS SCI DIRECTORATE,AMSMI,RD,WS,ST,REDSTONE ARSENAL,AL 35898. USA,RES LAB,ADELPHI,MD 20783. RP Scalora, M (reprint author), UNIV ALABAMA,DEPT ELECT & COMP ENGN,HUNTSVILLE,AL 35899, USA. RI DOWLING, JONATHAN/L-2749-2013 NR 19 TC 196 Z9 198 U1 2 U2 11 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1063-651X J9 PHYS REV E JI Phys. Rev. E PD AUG PY 1996 VL 54 IS 2 BP R1078 EP R1081 PG 4 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA VD674 UT WOS:A1996VD67400019 ER PT J AU Mayer, M Hollinger, J Ron, E Wozney, J AF Mayer, M Hollinger, J Ron, E Wozney, J TI Maxillary alveolar cleft repair in dogs using recombinant human bone morphogenetic protein-2 and a polymer carrier SO PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Article ID TRANSFORMING GROWTH-FACTOR; STRUCTURE-PROPERTY RELATIONSHIPS; MASSIVE POLY(ALPHA-HYDROXY ACIDS); FACTOR-BETA SUPERFAMILY; FOREIGN-BODY REACTIONS; AQUEOUS-MEDIA; OSTEOGENIC PROTEIN; INTERNAL-FIXATION; DEGRADATION; MEMBERS AB Recombinant human bone morphogenetic protein-2 was evaluated in maxillary alveolar clefts in 24 adult, skeletally mature Foxhound dogs. Bilateral clefts were prepared, 1 cm in bony width, lined with healthy epithelium, with functional teeth on each side, and were expected not to heal spontaneously with new bone. Preparation of bilateral clefts in 24 dogs permitted 48 recipient sites divided evenly among four treatments and two time periods (2 and 4 months), yielding six replicates per treatment per time. The overall goal for the study was to regenerate bone in the cleft using one of three treatments: (1) 200 mu g recombinant human bone morphogenetic protein-2 combined with the copolymer poly(lactide-co-glycolide) and autogenous blood, (2) poly(lactide-co-glycolide) and autogenous blood, or (3) an autograft from the posterior iliac crest. A fourth group consisted of untreated alveolar cleft defects. At designated times, dogs were euthanized, and the recipient beds with contiguous bone were recovered, processed, and assessed radiographically and histologically. Autograft-treated defects had more bone than other treatments at 2 months; however, by 4 months, there were no differences among treatments, except for the poly(lactide-co-glycolide) group, which had the least amount of bone. Response to the recombinant human bone morphogenetic protein-2 may have been suboptimal either because the dose was too low or because the poly(lactide-co-glycolide)-autogenous blood delivery system did not temporally maintain and spatially position recombinant human bone morphogenetic protein-2 at the recipient bed. In addition, the development of a nonhealing, critical-sized defect in the maxilla of the dog appears to require a more aggressive resection of bone to preclude spontaneous osseous regeneration. C1 OREGON HLTH SCI UNIV,DIV PLAST & RECONSTRUCT SURG,DEPT SURG ANAT & CELL BIOL,GELMED,PORTLAND,OR 97229. WALTER REED ARMY MED CTR,DEPT PLAST & RECONSTRUCT SURG,WASHINGTON,DC. WALTER REED ARMY MED CTR,CRANIOFACIAL CLEFT LIP & PALATE CTR,WASHINGTON,DC. NR 69 TC 87 Z9 87 U1 1 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0032-1052 J9 PLAST RECONSTR SURG JI Plast. Reconstr. Surg. PD AUG PY 1996 VL 98 IS 2 BP 247 EP 259 DI 10.1097/00006534-199608000-00006 PG 13 WC Surgery SC Surgery GA UY042 UT WOS:A1996UY04200006 PM 8764712 ER PT J AU Blanck, RR DeLeon, PH AF Blanck, RR DeLeon, PH TI Managed care: Strongly conflicting views SO PROFESSIONAL PSYCHOLOGY-RESEARCH AND PRACTICE LA English DT Editorial Material RP Blanck, RR (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 SN 0735-7028 J9 PROF PSYCHOL-RES PR JI Prof. Psychol.-Res. Pract. PD AUG PY 1996 VL 27 IS 4 BP 323 EP 324 PG 2 WC Psychology, Multidisciplinary SC Psychology GA UY825 UT WOS:A1996UY82500001 ER PT J AU Mahadik, SP Scheffer, RE AF Mahadik, SP Scheffer, RE TI Oxidative injury and potential use of antioxidants in schizophrenia SO PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS LA English DT Article; Proceedings Paper CT 2nd International Workshop on Cell Membrane Pathology in Schizophrenia CY OCT 06-08, 1995 CL LONDON, ENGLAND ID GAMMA-AMINOBUTYRIC ACID; CT-SCAN ABNORMALITIES; DEVELOPING RAT-BRAIN; DRUG-NAIVE PATIENTS; VITAMIN-E TREATMENT; GLUTATHIONE-PEROXIDASE; TARDIVE-DYSKINESIA; SUPEROXIDE-DISMUTASE; LIPID-PEROXIDATION; HYDROGEN-PEROXIDE AB There is increasing evidence that oxidative injury contributes to pathophysiology of schizophrenia, indicated by the increased lipid peroxidation products in plasma and CSF, and altered levels of both enzymatic and non-enzymatic antioxidants in chronic and drug-naive first-episode schizophrenic patients. The increased plasma lipid peroxidation is also supported by concomitant lower levels of esterified polyunsaturated essential fatty acids of red blood cell plasma membrane phospholipids. Because membrane phospholipids play a critical role in neuronal signal transduction, oxidative damage of these lipids may contribute to the proposed altered neurotransmitter receptor-mediated signal transduction and thereby alter information processing in schizophrenia. Adjunctive treatment with antioxidants (e.g. vitamins E and C, beta-carotene and quinones) at the initial stages of illness may prevent further oxidative injury and thereby ameliorate and prevent further possible deterioration of associated neurological and behavioral deficits in schizophrenia. C1 VET AFFAIRS MED CTR, AUGUSTA, GA 30912 USA. DWIGHT D EISENHOWER ARMY MED CTR, FT GORDON, GA USA. RP MED COLL GEORGIA, DEPT PSYCHIAT & HLTH BEHAV, AUGUSTA, GA 30912 USA. NR 117 TC 82 Z9 86 U1 1 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0952-3278 EI 1532-2823 J9 PROSTAG LEUKOTR ESS JI Prostaglandins Leukot. Essent. Fatty Acids PD AUG PY 1996 VL 55 IS 1-2 BP 45 EP 54 DI 10.1016/S0952-3278(96)90144-1 PG 10 WC Biochemistry & Molecular Biology; Cell Biology; Endocrinology & Metabolism SC Biochemistry & Molecular Biology; Cell Biology; Endocrinology & Metabolism GA VK014 UT WOS:A1996VK01400009 PM 8888122 ER PT J AU Mahadik, SP Shendarkar, NS Scheffer, RE Mukherjee, S Correnti, EE AF Mahadik, SP Shendarkar, NS Scheffer, RE Mukherjee, S Correnti, EE TI Utilization of precursor essential fatty acids in culture by skin fibroblasts from schizophrenic patients and normal controls SO PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS LA English DT Article; Proceedings Paper CT 2nd International Workshop on Cell Membrane Pathology in Schizophrenia CY OCT 06-08, 1995 CL LONDON, ENGLAND ID MAGNETIC-RESONANCE SPECTROSCOPY; DRUG-NAIVE PATIENTS; VITAMIN-E TREATMENT; LIPID-PEROXIDATION; SIGNAL TRANSDUCTION; TARDIVE-DYSKINESIA; MEMBRANE PHOSPHOLIPIDS; ARACHIDONIC-ACID; LIVER-CELLS; BRAIN AB Based on the lower levels of long-chain polyunsaturated analogs of essential fatty acids (EPUFAs) in plasma membrane phospholipids of red blood cells, brain and cultured skin fibroblasts from schizophrenic patients, a defective utilization (uptake, conversion to EPUFAs and incorporation into membrane phospholipids) of precursor EFAs has been suggested. Utilization of radiolabeled linoleic (LA, 18:2(n-6)) and alpha-linolenic (ALA, 18:3(n-3)) acids was studied in cultured skin fibroblasts from patients with established schizophrenia and at the first episode of psychosis, and normal controls. Uptake and incorporation of both the EFAs were similar in fibroblasts from both groups of patients studied compared with normal controls. However, although the utilization of LA into arachidonic acid (AA, 20:4n-6) was similar in patients and controls, the utilization of eicosapentaenoic acid (EPA, 20:5(n-3)) into docosahexaenoic acid (DHA, 22:6(n-3)) was significantly lower in first-episode psychotic patients (patients, 96.33 +/- 27.16 versus normals, 161.66 +/- 26.33 nmoles per mg total protein; P = < 0.001). This data indicates that the level of Delta 6- as well as Delta 5-desaturase may be normal. However, the levels of Delta 4-desaturase may be lower in fibroblasts from schizophrenic patients even at the first episode of psychosis. C1 VET AFFAIRS MED CTR, AUGUSTA, GA 30912 USA. DWIGHT D EISENHOWER ARMY MED CTR, FT GORDON, GA USA. RP MED COLL GEORGIA, DEPT PSYCHIAT & HLTH BEHAV, AUGUSTA, GA 30912 USA. FU NIMH NIH HHS [MH 46546] NR 58 TC 30 Z9 31 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0952-3278 EI 1532-2823 J9 PROSTAG LEUKOTR ESS JI Prostaglandins Leukot. Essent. Fatty Acids PD AUG PY 1996 VL 55 IS 1-2 BP 65 EP 70 DI 10.1016/S0952-3278(96)90147-7 PG 6 WC Biochemistry & Molecular Biology; Cell Biology; Endocrinology & Metabolism SC Biochemistry & Molecular Biology; Cell Biology; Endocrinology & Metabolism GA VK014 UT WOS:A1996VK01400012 PM 8888125 ER PT J AU Cole, MW Han, WY Casas, LM Eckart, DW Monahan, T Jones, KA AF Cole, MW Han, WY Casas, LM Eckart, DW Monahan, T Jones, KA TI The mechanisms of formation of ohmic contacts to AlGaAs: A microstructural, elemental diffusion and electrical investigation SO SCANNING LA English DT Article DE ohmic contact; interfacial microstructure; elemental diffusion ID GAAS; MORPHOLOGY; STABILITY AB Interfacial microstructure and phase composition of PtTiGePd ohmic contacts to heavily C-doped AlGaAs were investigated as a function of annealing temperatures. Results of the material analyses were used to explain the specific contact resistances measured for each thermal treatment. Evidence of interdiffusion and compound formation between AlGaAs and Pd was visible in a Ga-rich Pd-Ga-As reaction zone prior to heat treatment. As the annealing temperature was raised from 530 to 600 degrees C, As began to out-diffuse. At 600 degrees C, this As out-diffusion, which is critical to the formation of good p-type ohmic contacts, contributed to the creation and development of the laterally continous two-phase interfacial region, TiAs/Pd12Ga2Ge5, overlying the AlGaAs substrate. The minimum specific contact resistance was also achieved at this temperature. As the annealing temperature was elevated to 650 degrees C, the specific contact resistance degraded in response to intensive chemical diffusion and development of a broad, nonuniform multiphased interfacial region. RP Cole, MW (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU FAMS INC PI MAHWAH PA BOX 832, MAHWAH, NJ 07430 SN 0161-0457 J9 SCANNING JI Scanning PD AUG PY 1996 VL 18 IS 5 BP 379 EP 384 PG 6 WC Instruments & Instrumentation; Microscopy SC Instruments & Instrumentation; Microscopy GA VC034 UT WOS:A1996VC03400010 ER PT J AU Jeon, JB Sirenko, YM Kim, KW Littlejohn, MA Stroscio, MA AF Jeon, JB Sirenko, YM Kim, KW Littlejohn, MA Stroscio, MA TI Valence band parameters of wurtzite materials SO SOLID STATE COMMUNICATIONS LA English DT Article DE semiconductors; electronic band structure ID GAN AB We deduced the valence band parameters of several wurtzite materials (ZnS, CdS, CdSe, and GaN) by matching the results of existing full-band calculations of the energy spectrum with analytical expressions of the envelope-function formalism. The calculated A-, B-, and C-type hole dispersion relations show strongly anisotropic characteristics and anti-crossing features in spectrum due to band mixing effects. We demonstrated that for all materials considered except CdSe, the spherical cubic approximation for six Luttinger-like parameters holds with good accuracy, so that the anisotropy arises mainly owing to the crystal field splitting term. Thus, the top valence band may be described with (in addition to crystal held and spin-orbit splitting energies) only two Luttinger-like parameters, gamma(1) and gamma(2). Copyright (C) 1996 Published by Elsevier Science Ltd C1 USA, RES OFF, RES TRIANGLE PK, NC 27709 USA. RP N CAROLINA STATE UNIV, DEPT ELECT & COMP ENGN, RALEIGH, NC 27695 USA. NR 18 TC 20 Z9 20 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1098 EI 1879-2766 J9 SOLID STATE COMMUN JI Solid State Commun. PD AUG PY 1996 VL 99 IS 6 BP 423 EP 426 DI 10.1016/0038-1098(96)00282-7 PG 4 WC Physics, Condensed Matter SC Physics GA UW768 UT WOS:A1996UW76800010 ER PT J AU Moul, JW Bettencourt, MC Sesterhenn, IA Mostofi, FK McLeod, DG Srivastava, S Bauer, JJ AF Moul, JW Bettencourt, MC Sesterhenn, IA Mostofi, FK McLeod, DG Srivastava, S Bauer, JJ TI Protein expression of p53, bcl-2, and KI-67 (MIB-1) as prognostic biomarkers in patients with surgically treated, clinically localized prostate cancer SO SURGERY LA English DT Article; Proceedings Paper CT 57th Annual Meeting of the Society-of-University-Surgeons CY FEB 08-10, 1996 CL WASHINGTON, DC SP Soc Univ Surgeons ID RADICAL PROSTATECTOMY; CARCINOMA; DEATH; TIME AB Background. Protein expression in the primary tumor of the tumor suppressor gene p53 and the proto-oncogene bcl-2 have been shown to lie prognostic biomarkers of cancer recurrence after radical prostatectomy in patients with clinically localized prostate cancer. Cancer cell Proliferation as measured by immunohistochemical markers such as the MIB-1 antibody for Ki-67 has recently been suggested to be of prognostic value in prostate cancer. The goal of this study was to determine the clinical use of p53, Ki-67 (MIB-1), and bcl-2 immunohistochemical protein expression in the primary tumor as combined predictors of disease progression after radical prostatectomy (RP). Methods. Protein expressions of p53, Ki-67, and bcl-2 were evaluated in archival paraffin-embedded RP specimens from 162 patients monitored from 1 to 10 years (mean, 4.5 years) and correlated to stage, grade, race, and serologic (prostate-specific antigen) recurrence after operation. Results. Expression was defected in 112 (69.1%), 44 (27.2%), and 62 (38.3%) of 162 patients for p53 (1+ or greater), bcl-2 (1+ or greater), and Ki-67 (2+ or greater), respectively. Biomarker expressions were not correlated to age and race; however, all increased with increasing stage and grade. The degree Of expression by percentage of malignant cells staining correlated to recurrence for p53 and Ki-67 but nob for bcl-2. All three markers were correlated to raw and Kaplan-Meier recurrence by means of univariate analysis with recurrence estimates at 6 years of 60.7% versus 24.2%, 84.2% versus 38.6%, and 72.4% versus 30.6% comparing positive versus negative expression of p53, bcl-2, and Ki-67, respectively. p53 and bcl-2 remained as independent prognostic markers by Cox multivariate regression analysis. Although Ki-67 did not remain an independent marker, it added prognostic use in certain subsets of patients. Conclusions. p53 bcl-2, and Ki-67 (MIB-1) appear to be important biomarkers to Predict recurrence in patients with clinically localized prostate cancer after RP, and all three biomarkers deserve further study. C1 WALTER REED ARMY MED CTR,DEPT SURG,UROL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,DEPT GENITOURINARY PATHOL,WASHINGTON,DC 20306. RP Moul, JW (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,CTR PROSTATE DIS RES,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 28 TC 103 Z9 104 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0039-6060 J9 SURGERY JI Surgery PD AUG PY 1996 VL 120 IS 2 BP 159 EP 167 DI 10.1016/S0039-6060(96)80283-2 PG 9 WC Surgery SC Surgery GA VK886 UT WOS:A1996VK88600006 PM 8751578 ER PT J AU George, SG Hoover, JJ Douglas, NH AF George, SG Hoover, JJ Douglas, NH TI Two mouthless cypriniform fishes from Louisiana SO TEXAS JOURNAL OF SCIENCE LA English DT Article RP George, SG (reprint author), USA,ENGINEER WATERWAYS EXPT STN,DYNTEL CZP,ER-A,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU TEXAS ACAD SCI PI LUBBOCK PA TEXAS TECH UNIV, LUBBOCK, TX 79401 SN 0040-4403 J9 TEX J SCI JI Tex. J. Sci. PD AUG PY 1996 VL 48 IS 3 BP 243 EP 246 PG 4 WC Ecology; Zoology SC Environmental Sciences & Ecology; Zoology GA VL146 UT WOS:A1996VL14600006 ER PT J AU Baskin, SI Nealley, EW Lempka, JC AF Baskin, SI Nealley, EW Lempka, JC TI The effects of EDRF/NO releasers or calcium ionophore A23187 on cyanide toxicity in mice SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article ID NITRIC-OXIDE SYNTHASE; RELAXING FACTOR; HEART-FAILURE; VASCULAR TONE; ENDOTHELIUM; HYDRALAZINE; INHIBITION; TOLERANCE AB Cyanide (CN) is a well-recognized poison whose complete actions are unclear. It has been shown that a vasoactive role may be partially responsible for the toxic effects of CN. Sodium nitrite, a known methemoglobin former and vasodilator, has been used to treat CN toxicity. It is rapidly transformed to nitric oxide (NO) which is thought to be endothelium-derived relaxing factor (EDRF). Since the literature suggests that NO can influence the biological effects of CN, studies were undertaken to determine if compounds known to release EDRF/NO will modify CN toxicity. Mice were administered a series of compounds which act through EDRF/NO release. These substances included, platelet-activating factor (PAF), hydralazine, bradykinin, histamine, calcium ionophore A23187, carbachol, or substance P at 0.060, 98.7, 50.0, 125, 1.0, 2.26, and 1.0 mg/kg, respectively. As a control, N-G-monomethyl-L-arginine (NMA) 70 mg/kg, which inhibits NO synthesis, was administered to mice iv (tail vein) in combination with each test compound. All test compounds and NMA were administered prior to NaCN: NMA, 5 min; carbachol, 0.5 min; hydralazine, 0.5 min; bradykinin, 1 min; histamine, 1 min; substance P, 4 min; PAF, 5 min; and A23187, 5 min. Dose-response relationships were analyzed by probit dose-response methods and protective ratios for each compound were computed. Results suggest (i) that a portion of the action of CN is affected by a particular EDRF/NO-releasing compound, suggesting that each drug specifically affects regional EDRF/NO receptor sites, and (ii) that NO can play a role as a component in CN intoxication. It is suggested that CN does not act uniformly on all EDRF/NO receptor sites to produce toxicity and site-specific EDRF/NO agents may be useful for treating CN. (C) 1996 Academic Press, Inc. RP Baskin, SI (reprint author), USA,MED RES INST CHEM DEF,DIV PHARMACOL,ABERDEEN PROVING GROUND,MD 21010, USA. NR 33 TC 1 Z9 1 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD AUG PY 1996 VL 139 IS 2 BP 349 EP 355 DI 10.1006/taap.1996.0175 PG 7 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA VD515 UT WOS:A1996VD51500016 PM 8806852 ER PT J AU Sheridan, RE AF Sheridan, RE TI Protonophore antagonism of botulinum toxin in mouse muscle SO TOXICON LA English DT Article ID CLOSTRIDIAL NEUROTOXINS; MONENSIN; INHIBITION; MECHANISM AB Botulinum neurotoxins (BoNT) are thought to enter cells through endocytotic vesicles where acidification is required for release of these toxins into the cytoplasm. Two ionophores, nigericin and monensin, that increase membrane permeability to H+ and K+ or H+, Na+ and K+, respectively, block vesicle acidification by acting as H+ shunts to neutralize pH gradients. Nanomolar concentrations of nigericin or monensin delayed development of blockade in BoNT-A or BoNT-B treated muscles two- to threefold over onset times in unprotected muscles. However, higher concentrations of the ionophores directly blocked synapses. Thus, nigericin and monensin could delay onset of BoNT paralysis only over a narrow range of concentrations. Copyright (C) 1996 Elsevier Science Ltd RP Sheridan, RE (reprint author), USA,MED RES INST CHEM DEF,DIV PATHOPHYSIOL,NEUROTOXICOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 14 TC 18 Z9 18 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD AUG PY 1996 VL 34 IS 8 BP 849 EP 855 DI 10.1016/0041-0101(96)00040-2 PG 7 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA VH836 UT WOS:A1996VH83600004 PM 8875772 ER PT J AU Schlagenhauf, P Steffen, R Lobel, H Johnson, R Letz, R Tschopp, A Vranjes, N Bergqvist, Y Ericsson, O Hellgren, U Rombo, L Mannino, S Handschin, J Sturchler, D AF Schlagenhauf, P Steffen, R Lobel, H Johnson, R Letz, R Tschopp, A Vranjes, N Bergqvist, Y Ericsson, O Hellgren, U Rombo, L Mannino, S Handschin, J Sturchler, D TI Mefloquine tolerability during chemoprophylaxis: Focus on adverse event assessments, stereochemistry and compliance SO TROPICAL MEDICINE & INTERNATIONAL HEALTH LA English DT Article DE mefloquine; adverse event ID CONSTRUCTION PAINTERS; PLASMODIUM-FALCIPARUM; MALARIA PROPHYLAXIS; TRAVELERS; ENANTIOMERS; SOLVENTS; REGIMENS; SYMPTOMS; INVITRO AB This longitudinal study of travellers to Africa taking mefloquine (MQ) chemoprophylaxis aimed to quantify and assess non-serious adverse events (AE) occurring during short-term prophylaxis and relate these to concentrations of racemic MQ, its enantiomers and metabolite. A total of 420 volunteers (52% F) participated. AEs with some impact on activities were reported by 11.2% of participants including 7.9% of neurological/psychiatric symptoms. Women were more likely to report AEs (P=0.02). The standardized questionnaires used showed more pathological indicators in travellers who reported subjective AE with significantly more dizziness, distress, sleep disturbances and a high total mood disturbance (TMD) in the AE group. There was, however, no significant performance deficit in computerized psychomotor tests in those experiencing AE. Furthermore, no significant differences were observed in enantiomer ratios, metabolite concentrations, or racemic MQ levels in participants with or without AEs suggesting that these factors are not the main predictors of mefloquine intolerability. C1 CTR DIS CONTROL & PREVENT,NATL CTR INFECT DIS,ATLANTA,GA. USA,ENVIRONM MED RES INST,NATICK,MD. ROLLINS SCH PUBL HLTH,DEPT BEHAV SCI & HLTH EDUC,ATLANTA,GA. FALUN CENT HOSP,DEPT CHEM,FALUN,SWEDEN. KAROLINSKA INST,HUDDINGE HOSP,DEPT INFECT DIS,S-10401 STOCKHOLM,SWEDEN. UNIV G DANNUNZIO,SCH MED,CHIETI,ITALY. F HOFFMANN LA ROCHE & CO LTD,TROP MED UNIT,CH-4002 BASEL,SWITZERLAND. RP Schlagenhauf, P (reprint author), UNIV ZURICH,INST SOCIAL & PREVENT MED,SUMATRASTR 30,CH-8006 ZURICH,SWITZERLAND. NR 32 TC 53 Z9 53 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 1360-2276 J9 TROP MED INT HEALTH JI Trop. Med. Int. Health PD AUG PY 1996 VL 1 IS 4 BP 485 EP 494 DI 10.1046/j.1365-3156.1996.d01-85.x PG 10 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA VV946 UT WOS:A1996VV94600012 PM 8765456 ER PT J AU Thompson, IM AF Thompson, IM TI Reflections of a prostate cancer patient - Comment SO UROLOGY LA English DT Editorial Material RP Thompson, IM (reprint author), BROOKE ARMY MED CTR,DEPT SURG MCHE5D,BLDG 3600,3851 ROGER BROOKE DR,FT SAM HOUSTON,TX 78234, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD AUG PY 1996 VL 48 IS 2 BP 176 EP 177 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA VD099 UT WOS:A1996VD09900002 ER PT J AU Yan, CH Rill, WL Malli, R Hewetson, J Naseem, H Tammariello, R Kende, M AF Yan, CH Rill, WL Malli, R Hewetson, J Naseem, H Tammariello, R Kende, M TI Intranasal stimulation of long-lasting immunity against aerosol ricin challenge with ricin toxoid vaccine encapsulated in polymeric microspheres SO VACCINE LA English DT Article DE intranasal immunization; ricin toxoid vaccine; poly(lactide-co-glycolide) microspheres; systemic and mucosal antibodies ID BIODEGRADABLE MICROPARTICLES; DELIVERY SYSTEMS; IMMUNIZATION; LIPOSOMES; RELEASE; MICE; ANTIBODIES; ADJUVANTS; RESPONSES; INFECTION AB Intranasal (i.n.) immunization with ricin toxoid (RT) vaccine encapsulated in poly(lactide-co-glycolide) microspheres (RT-PLG-Ms) and poly(L-lactide) microspheres (RT-PLA-Ms) stimulated systemic and mucosal immune response and protected mice from aerosolized ricin intoxication. High titers of anti-ricin IgG2a were stimulated in serum of mice with one or two doses of RT-Ms 6 weeks postimmunization. However, in the lungs, no IgG2a or total IgG was elicited either with RT-Ms or with aqueous RT. At 6 weeks postimmunization, a single dose of the RT-Ms stimulated secretory IgA (sIgA) in the lungs of four of six mice, but a second immunizing dose did not enhance the stimulation. A single dose of aqueous RT vaccine failed to stimulate sIgA in the lungs, while, a second dose induced sIgA in 50% of the mice. One or two i.n. doses of RT-Ms protected most of the mice against lethal aerosol-delivered ricin toxin 6 weeks post-immunization. In contrast, protection was absent or marginal after one or two doses of aqueous RT vaccine. In both studies, the protection against lethal aerosol challenge was significantly better with one dose of RT-Ms than with two doses of aqueous vaccine, which may be attributed to the induction of sIgA in the lungs and the serum. Duration of the IgG2a and IgA in the serum, particularly that of IgG2a was much longer after the administration of RT-Ms than after the aqueous vaccine. The geometric mean IgG2a titers stimulated with two doses of RT-Ms remained high during 40 weeks postimmunization and were up to 25 times higher than the titers induced with aqueous RT vaccine. After 6 weeks, the IgG2a induced by two doses of aqueous vaccine was no longer detectable. Persistence of antibody response was predictive of efficacy. At 1 year postimmunization with two doses of RT-Ms, 100% of mice protected against lethal ricin challenge. However, at the same time no protection was afforded by two doses of aqueous RT. The results of the present study consistently demonstrated the advantages of microencapsulated RT vaccine to stimulate effective and long-lasting protection by i.n. administration. C1 USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702. NR 28 TC 50 Z9 50 U1 0 U2 2 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD AUG PY 1996 VL 14 IS 11 BP 1031 EP 1038 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA VF400 UT WOS:A1996VF40000003 PM 8879098 ER PT J AU Alexander, WA Hartman, AB Oaks, EV Venkatesan, MM AF Alexander, WA Hartman, AB Oaks, EV Venkatesan, MM TI Construction and characterization of virG (icsA)-deleted Escherichia coli K12 Shigella flexneri hybrid vaccine strains SO VACCINE LA English DT Article DE shigella; vaccine; virG deletion ID INVASION PLASMID ANTIGENS; 2A SOMATIC ANTIGEN; LIVE VACCINE; ORAL VACCINATION; SALMONELLA-TYPHI; MONKEYS; IMMUNOGENICITY; PROTECTION; CANDIDATE; INFECTION AB Human challenge studies with EcSf2a-2, an aroD deletion-attenuated Escherichia coli K12-Shigella flexneri hybrid vaccine expressing S. flexneri 2a somatic antigen and the invasive phenotype indicated that, at doses of 2 x 10(9) bacteria, EcSf2a-2 was immunogenic but also reactogenic and therefore not sufficiently attenuated. Two factors that may contribute to the residual reactogenicity are the spontaneous appearance of plaque-positive variants in the E. coli K12 recipient and the presence of the arg locus encoding enterotoxin or cytotoxin, transferred from S. flexneri 2a into the E. coli recipient. EcSf2a-3 was derived from EcSf2a-2 by introducing a deletion in the virG gene, whose expression is required for plaque formation and keratoconjunctivitis in guinea pigs. EcSf2a-5 contains the same deletion in the E. coli-S. flexneri hybrid strain, 7921, but does not contain the arg locus. Lack of virG expression in these hybrid strains did not affect the immune response to LPS or the development of protective immunity in the guinea pig model. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTER INFECT,WASHINGTON,DC 20307. NR 41 TC 9 Z9 9 U1 0 U2 0 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD AUG PY 1996 VL 14 IS 11 BP 1053 EP 1061 DI 10.1016/0264-410X(96)00002-3 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA VF400 UT WOS:A1996VF40000007 PM 8879102 ER PT J AU VandeVerg, LL Bendiuk, NO Kotloff, K Marsh, MM Ruckert, JL Puryear, JL Taylor, DN Hartman, AB AF VandeVerg, LL Bendiuk, NO Kotloff, K Marsh, MM Ruckert, JL Puryear, JL Taylor, DN Hartman, AB TI Cross-reactivity of Shigella flexneri serotype 2a O antigen antibodies following immunization or infection SO VACCINE LA English DT Article DE Shigella flexneri 2a; LPS; antibodies; cross-reactivity; vaccine ID ESCHERICHIA-COLI; SONNEI INFECTION; SOMATIC ANTIGEN; VACCINE; MONKEYS; LIPOPOLYSACCHARIDE; IMMUNOGENICITY; PROTECTION; EFFICACY; VOLUNTEERS AB To study the cross-reactivity pattern of Shigella flexneri 2a O-antigen antibodies, sera from humans and monkeys challenged with S. flexneri 2a, and from humans and guinea pigs immunized with a recombinant vaccine expressing serotype 2a O-antigen, were tested against a panel of lipopolysaccharide extracted from heterologous S. flexneri. Sera from the two groups of humans, who volunteers in either a clinical challenge or vaccination study, showed similar patterns: cross-reactivity was more often seen with IgA antibodies, and these were mostly cross-reactive with serotype 2b, which shares the type II antigen, and serotypes 1a, 5a, and Y, which share 4 or 3, 4 group antigen, with 2a. The majority of sera from immunized guinea pigs showed both IgG and IgA cross-reactivity with 1a, 5a, and Y, but not 2b. The majority of sera from challenged monkeys showed cross-reactivity with almost all flexneri serotypes tested, with 1a, 2b, Y being recognized most often, and the cross-reactive antibodies were more often IgG than IgA. These results show that either immunization or challenge with the 2a serotype induces cross-reactive antibodies which recognize similar subsets of heterologous serotypes, and suggest that it may be possible to design multivalent vaccines against S. flexneri. C1 UNIV MARYLAND,CTR VACCINE DEV,BALTIMORE,MD 21201. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT CLIN TRIALS,WASHINGTON,DC 20307. RP VandeVerg, LL (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTER INFECT,WASHINGTON,DC 20307, USA. RI kotloff, karen/E-7768-2012 OI kotloff, karen/0000-0003-1808-6431 NR 29 TC 23 Z9 23 U1 0 U2 2 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD AUG PY 1996 VL 14 IS 11 BP 1062 EP 1068 DI 10.1016/0264-410X(96)00006-0 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA VF400 UT WOS:A1996VF40000008 PM 8879103 ER PT J AU IaconoConnors, LC Smith, JF Ksiazek, TG Kelley, CL Schmaljohn, CS AF IaconoConnors, LC Smith, JF Ksiazek, TG Kelley, CL Schmaljohn, CS TI Characterization of Langat virus antigenic determinants defined by monoclonal antibodies to E,NS1 and preM and identification of a protective, non-neutralizing preM-specific monoclonal antibody SO VIRUS RESEARCH LA English DT Article DE hybridomas; monoclonal antibodies; tick-borne encephalitis ID JAPANESE ENCEPHALITIS-VIRUS; RECOMBINANT VACCINIA VIRUS; NONSTRUCTURAL PROTEIN NS1; LETHAL DENGUE INFECTION; WEST NILE FLAVIVIRUS; YELLOW-FEVER; STRUCTURAL GLYCOPROTEIN; CROSS-NEUTRALIZATION; PROTEOLYTIC CLEAVAGE; PASSIVE TRANSFER AB Hybridomas secreting monoclonal antibodies (MAb) to the tick-borne encephalitis (TEE) group virus, Langat virus (LGTV), were prepared. Of more than 200 MAb screened, 19 antibodies, which cross-reacted with the etiologic agent of Central European encephalitis, were selected for further characterization. Of these MAb, 14 were specific for LGTV E glycoprotein, two for the NS1 protein, and three for preM protein. The two NS1-specific MAb and two of the E-specific MAb reacted with all six of the other TEE group viruses tested while the remainder of the E-specific MAb failed to recognize at least one of the viruses. None of the MAb neutralized LGTV in cell culture assays, but one of the preM-specific MAb protected weanling mice against a virulent LGTV challenge. Although protective antibodies to E and NS1 proteins of TEE viruses were reported, our data provided the first evidence for protection by a non-neutralizing antibody to the preM or M protein of any of the tick-borne flaviviruses. C1 USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21702. USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FT DETRICK,MD 21702. NR 40 TC 32 Z9 33 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-1702 J9 VIRUS RES JI Virus Res. PD AUG PY 1996 VL 43 IS 2 BP 125 EP 136 DI 10.1016/0168-1702(96)01325-1 PG 12 WC Virology SC Virology GA VA176 UT WOS:A1996VA17600003 PM 8864202 ER PT J AU Peters, JC Easton, DJ AF Peters, JC Easton, DJ TI Runoff simulation using radar rainfall data SO WATER RESOURCES BULLETIN LA English DT Article DE hydrograph analysis and modeling; simulation; surface water hydrology; radar AB Rainfall data products generated with the national network of WSR-88D radars are an important new data source provided by the National Weather Service. Radar-based data include rainfall depth on an hourly basis for grid cells that are nominally 4 km square. The availability of such data enables application of improved techniques for rainfall-runoff simulation. A simple quasi-distributed approach that applies a linear runoff transform to gridded rainfall excess has been developed. The approach is an adaptation of the Clark conceptual runoff model, which employs translation and linear storage. Data development for, and results of, an initial application to a 4160 km(2) watershed in the Midwestern U.S. are illustrated. C1 UNIV CALIF DAVIS,DEPT CIVIL ENGN,DAVIS,CA 95616. RP Peters, JC (reprint author), USA,CORPS ENGINEERS,HYDROL ENGN CTR,609 2ND ST,DAVIS,CA 95616, USA. NR 15 TC 26 Z9 26 U1 0 U2 0 PU AMER WATER RESOURCES ASSOC PI HERNDON PA 950 HERNDON PARKWAY SUITE 300, HERNDON, VA 22070-5528 SN 0043-1370 J9 WATER RESOUR BULL JI Water Resour. Bull. PD AUG PY 1996 VL 32 IS 4 BP 753 EP 760 PG 8 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA VE209 UT WOS:A1996VE20900009 ER PT J AU Hamilton, HR AF Hamilton, HR TI Identification and analysis of outdoor recreation habitats: The recreation habitat analysis method SO WATER RESOURCES BULLETIN LA English DT Article DE recreation management; attribute; ecosystem; habitat; recreation model; recreation; site evaluation; suitability index AB This paper describes a concept for identification and ranking of outdoor recreation habitats using principles of ecology as a guide. The Habitat Evaluation Procedures (HEP) is a commonly used technique for assessment of human impacts on the vigor of wildlife species, and serves as the model for the Recreation Habitat Analysis Method (RHAM). Recreation activities are dependent on habitat attributes for their success just as are wildlife species. A sample model is described for recreation activities at large, multi-purpose lakes. RHAM could be applied to recreation experiences in a variety of settings including smaller water bodies and riparian and terrestrial ecosystems. RP Hamilton, HR (reprint author), USA,ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 11 TC 0 Z9 1 U1 1 U2 3 PU AMER WATER RESOURCES ASSOC PI HERNDON PA 950 HERNDON PARKWAY SUITE 300, HERNDON, VA 22070-5528 SN 0043-1370 J9 WATER RESOUR BULL JI Water Resour. Bull. PD AUG PY 1996 VL 32 IS 4 BP 761 EP 766 PG 6 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA VE209 UT WOS:A1996VE20900010 ER PT J AU Mahadik, SP Mukherjee, S Horrobin, DF Jenkins, K Correnti, EE Scheffer, RE AF Mahadik, SP Mukherjee, S Horrobin, DF Jenkins, K Correnti, EE Scheffer, RE TI Plasma membrane phospholipid fatty acid composition of cultured skin fibroblasts from schizophrenic patients: Comparison with bipolar patients and normal subjects SO PSYCHIATRY RESEARCH LA English DT Article DE arachidonic acid; docosahexaenoic acid; essential fatty acids ID DRUG-NAIVE PATIENTS; ARACHIDONIC-ACID; LINOLENIC ACID; DOCOSAHEXAENOIC ACID; BRAIN; CELLS; RATS; ERYTHROCYTES; METABOLISM; DEFICIENCY AB Recent studies have found lower red cell plasma membrane contents and composition of the long chain polyunsaturated essential fatty acid derivatives, particularly arachidonic acid and docosahexaenoic acid, in a subgroup of chronic schizophrenic patients. These fatty acids are particularly enriched in the brain. Red blood cell levels of fatty acids are influenced by diet, medications, and other factors. Cell plasma membrane compositions of arachidonic and docosahexaenoic acids were therefore examined in cultured skin fibroblasts from 12 schizophrenic patients, 8 of whom were drug-naive and in a first episode of psychosis, 6 bipolar patients, and 8 normal control subjects. Docosahexaenoic acid as well as total n-3 essential fatty acid contents were significantly lower in cell lines from schizophrenic patients than in cell lines from bipolar patients and normal subjects, with no difference between the latter two groups, Arachidonic acid levels did not differ across the groups. The essential fatty acid profile observed is consistent with deficient Delta-4 desaturase activity in schizophrenic patients. C1 MED COLL GEORGIA, DEPT PSYCHIAT, AUGUSTA, GA 30912 USA. DEPT VET AFFAIRS MED CTR, PSYCHIAT SERV, AUGUSTA, GA USA. DEPT VET AFFAIRS MED CTR, RES SERV, AUGUSTA, GA USA. EFAMOL RES INST, HALIFAX, NS, CANADA. DD EISENHOWER ARMY MED CTR, DEPT PSYCHIAT & NEUROL, FT GORDON, GA USA. NR 58 TC 67 Z9 72 U1 0 U2 1 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0165-1781 J9 PSYCHIAT RES JI Psychiatry Res. PD JUL 31 PY 1996 VL 63 IS 2-3 BP 133 EP 142 DI 10.1016/0165-1781(96)02899-5 PG 10 WC Psychiatry SC Psychiatry GA VF721 UT WOS:A1996VF72100004 PM 8878309 ER PT J AU Dubey, M Lareau, RT Cole, MW Jones, KA West, LC Roberts, CW Piscani, E AF Dubey, M Lareau, RT Cole, MW Jones, KA West, LC Roberts, CW Piscani, E TI Oxygen contamination of low temperature ultrahigh vacuum-deposited Ge films on GaAs SO APPLIED PHYSICS LETTERS LA English DT Article ID GROWTH AB The Fourier transform infrared absorption spectrum for the range of 500-4000 cm(-1) wave numbers was measured fur several Ge films deposited on GaAs using ultrahigh vacuum e-beam deposition at various substrate temperatures ranging from room temperature (RT) to 500 degrees C. Spectra indicate oxygen incorporation at low deposition temperatures whether or not the native oxide was removed from the substrate prior to Film deposition. Using transmission electron microscopy, we show that Ge films deposited at RT and 100 degrees C on a (100) GaAs surface that did nor have the oxides removed fire amorphous while those deposited at 100 degrees C with the oxide removed are crystalline, but are highly defective. Secondary ion mass spectroscopy (SIMS) measurements show that the amorphous films at RT contain more than two orders of magnitude more oxygen than the films deposited at 100 degrees C or a single crystal film deposited at 400 degrees C. Oxygen-18 diffusion studies definitively show that the excess oxygen in the amorphous films percolates in from the atmosphere. SIMS studies further reveal that thermally removing the GaAs substrate surface oxide or depositing an Ari firm on top of the Ge film has little effect on the incorporation of oxygen. (C) 1996 American Institute of Physics. C1 INTEGRATED PHOTON SYST INC,CLARKSBURG,NJ 08510. RP Dubey, M (reprint author), USA,RES LAB,PSD,FT MONMOUTH,NJ 07703, USA. NR 7 TC 2 Z9 2 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 22 PY 1996 VL 69 IS 4 BP 556 EP 558 DI 10.1063/1.117785 PG 3 WC Physics, Applied SC Physics GA WB364 UT WOS:A1996WB36400040 ER PT J AU Cremers, DA Jeffries, J Miziolek, AW AF Cremers, DA Jeffries, J Miziolek, AW TI Feature issue on applied spectroscopy for sensors and chemical analysis: Introduction SO APPLIED OPTICS LA English DT Editorial Material C1 USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005. RP Cremers, DA (reprint author), LOS ALAMOS NATL LAB,CHEM SCI & TECHNOL DIV,GRP CST1,MS J565,LOS ALAMOS,NM 87545, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD JUL 20 PY 1996 VL 35 IS 21 BP 3991 EP 3991 DI 10.1364/AO.35.003991 PG 1 WC Optics SC Optics GA VA608 UT WOS:A1996VA60800001 PM 21102800 ER PT J AU Wormhoudt, J Shorter, JH McManus, JB Kebabian, PL Zahniser, MS Davis, WM Cespedes, ER Kolb, CE AF Wormhoudt, J Shorter, JH McManus, JB Kebabian, PL Zahniser, MS Davis, WM Cespedes, ER Kolb, CE TI Tunable infrared laser detection of pyrolysis products of explosives in soils SO APPLIED OPTICS LA English DT Article; Proceedings Paper CT OSA 1995 Annual Meeting CY 1995 CL PORTLAND, OR SP Opt Soc Amer ID TEMPERATURE-MEASUREMENTS; ABSORPTION-SPECTROSCOPY; THERMAL-DECOMPOSITION; FLAME; MECHANISMS; KINETICS; CO AB A research program involving two applications of tunable infrared laser differential absorption spectroscopy (TILDAS) with multipass, long-path absorption cells to the detection of explosives contamination in soils is reported. In the first application, sensitive, specific real-time species concentration measurements by TILDAS have led to new understanding of the processes involved in explosives detection by the heating of contaminated soils and the quantification of the resulting pyrolysis gases. In the second, we present results of our calculations of the properties of astigmatic off-axis resonator absorption cells, which show that useful TILDAS path lengths can be achieved inside a cone penetrometer probe. (C) 1996 Optical Society of America C1 USA,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP Wormhoudt, J (reprint author), AERODYNE RES INC,CTR CHEM & ENVIRONM PHYS,BILLERICA,MA 01821, USA. RI Kolb, Charles/A-8596-2009 NR 17 TC 20 Z9 21 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD JUL 20 PY 1996 VL 35 IS 21 BP 3992 EP 3997 DI 10.1364/AO.35.003992 PG 6 WC Optics SC Optics GA VA608 UT WOS:A1996VA60800002 PM 21102801 ER PT J AU Modiano, SH McNesby, KL Marsh, PE Bolt, W Herud, C AF Modiano, SH McNesby, KL Marsh, PE Bolt, W Herud, C TI Quantitative measurements by fourier-transform infrared spectroscopy of toxic gas production during inhibition of JP-8 fires by CF3Br and C3F7H SO APPLIED OPTICS LA English DT Article; Proceedings Paper CT OSA 1995 Annual Meeting CY 1995 CL PORTLAND, OR SP Opt Soc Amer DE flame inhibition; toxic gas production; FT-IR spectroscopy; CF3Br; CF2O; JP-8 fuel fires AB Fourier-transform infrared spectroscopy is used to monitor gases generated during chemical inhibition of JP-8 fuel pool fires burning in air. Gas samples are taken from a location that approximates the position of an individual who is using a handheld extinguisher to subdue the fire. These gas samples are flowed through a 10-m path-length multipass optical cell placed in the sample beam of a Fourier-transform infrared spectrometer. Gas samples are analyzed before and during application of C3F7H (trade name FM200) and CF3Br (Halon 1301) to the fire. It is shown that application of these halogenated hydrocarbons to JP-8 pool fires produces significant quantities of acid gases (HF and HBr) and of CF2O. A calculation of the concentrations (in parts in 10(6)) of these gases and other gaseous combustion products, based on observed absorbances, is presented. We believe this is the first quantitative simultaneous measurement of HF, HBr, HCl, and CF2O production during chemical inhibition of real fires. C1 ABERDEEN TEST CTR, CHEM BRANCH, ABERDEEN PROVING GROUND, MD 21005 USA. RP Modiano, SH (reprint author), USA, RES LAB, ABERDEEN PROVING GROUND, MD 21005 USA. NR 14 TC 11 Z9 11 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JUL 20 PY 1996 VL 35 IS 21 BP 4004 EP 4008 DI 10.1364/AO.35.004004 PG 5 WC Optics SC Optics GA VA608 UT WOS:A1996VA60800004 PM 21102803 ER PT J AU Daniel, RG McNesby, KL Miziolek, AW AF Daniel, RG McNesby, KL Miziolek, AW TI Application of tunable diode laser diagnostics for temperature and species concentration profiles of inhibited low-pressure flames SO APPLIED OPTICS LA English DT Article; Proceedings Paper CT OSA 1995 Annual Meeting CY 1995 CL PORTLAND, OR SP Opt Soc Amer DE tunable diode laser; absorption spectroscopy; Halon alternative compound; combustion diagnostic; two-line thermometry ID ABSORPTION AB We have employed tunable diode laser absorption spectroscopy (TDLAS) to characterize low-pressure premixed CH4/O-2/Ar flames inhibited with Halon 1301 (CF3Br) and the candidate Halon alternative compounds FE-13 (CF3H) and HFC-125 (C2F5H). This work is part of a larger program designed to help identify replacement fire-suppression compounds for the currently used Halon 1301. We have used CO two-line thermometry to profile the temperature in low-pressure laminar dames and have determined concentration profiles for a large number of flame species, including reactive intermediates. To date, we have detected 12 dame species by using TDLAS in our laboratory and report on seven of them here: CH4, H2O, CO, CF2O, CF2H2, CF3H, and CF4. To the best of our knowledge, this is the first time the last four species have been observed in flame by the use of TDLAS. Our data are important for validating the detailed kinetic mechanisms of chemical flame inhibition. Our results indicate that TDLAS is a versatile and powerful diagnostic technique for studying combustion processes. RP Daniel, RG (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 22 TC 22 Z9 22 U1 2 U2 10 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD JUL 20 PY 1996 VL 35 IS 21 BP 4018 EP 4025 DI 10.1364/AO.35.004018 PG 8 WC Optics SC Optics GA VA608 UT WOS:A1996VA60800006 PM 21102805 ER PT J AU Pastel, RL Sausa, RC AF Pastel, RL Sausa, RC TI Detection of NO and NO2 by (2+2) resonance-enhanced multiphoton ionization and photoacoustic spectroscopy near 454 nm SO APPLIED OPTICS LA English DT Article; Proceedings Paper CT OSA 1995 Annual Meeting CY 1995 CL PORTLAND, OR SP Opt Soc Amer ID MULTI-PHOTON IONIZATION; DYE-LASER; PHOTOFRAGMENTATION; DYNAMICS; SPECTROMETRY; FLUORESCENCE; EXCITATION; STATE AB Trace concentrations of NO and NO2 are detected with a dye laser operating near 454 nm. NO is detected by a (2 + 2) resonance-enhanced multiphoton ionization process by means of NO A (2) Sigma(+)-X (II)-I-2(0, 0) transitions with miniature electrodes, and NO2 is detected by a one-photon absorption photoacoustic process by means of NO2 (A) over tilde' B-2(1)(0, 8, 0)- (X) over tilde (2)A(1)(0, 0, 0) transitions with a miniature microphone. Rotationally resolved excitation spectra show that the spectral resolution is sufficiently high to identify these species at 1 atm. The technique's analytical merits are evaluated as functions of concentration, pressure, and laser intensities. Low laser intensities favor NO2 photoacoustic detection whereas high laser intensities favor NO ionization. Limits of detection (signal-to-noise ratio 3) of 160 parts in 10(9) for NO and 400 parts in 10(9) for NO2 are determined at 1 atm for a 10-s integration time. Signal response and noise analyses show that three decades of NO/NO2 mixtures can be measured with a computational relative error in concentration that is three times the relative error in measuring the NO and NO2 signals. (C) 1996 Optical Society of America RP Pastel, RL (reprint author), USA,RES LAB,AMSRL WT PC,ABERDEEN PROVING GROUND,MD 21005, USA. NR 24 TC 17 Z9 19 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD JUL 20 PY 1996 VL 35 IS 21 BP 4046 EP 4052 DI 10.1364/AO.35.004046 PG 7 WC Optics SC Optics GA VA608 UT WOS:A1996VA60800010 PM 21102809 ER PT J AU Ligon, DA Chen, TW Gillespie, JB AF Ligon, DA Chen, TW Gillespie, JB TI Determination of aerosol parameters from light-scattering data using an inverse Monte Carlo technique SO APPLIED OPTICS LA English DT Article; Proceedings Paper CT OSA 1995 Annual Meeting CY 1995 CL PORTLAND, OR SP Opt Soc Amer ID COLLOIDAL PARTICLES; SIZE DISTRIBUTION AB An inverse, Monte Carlo (IMC) technique is developed to solve the electromagnetic inverse-scattering problem from generally complex distributions of dielectric particles. One can verify the technique using simulated scattering data from aerosols composed of spherical dielectrics. The IMC method is found to give accurate inversion results even when the data have a signal-to-noise ratio to as low as 3:1. (C) 1996 Optical Society of America C1 USA,RES LAB,BATTLEFIELD ENVIRONM,WHITE SANDS MISSILE RANGE,NM 88002. RP Ligon, DA (reprint author), NEW MEXICO STATE UNIV,DEPT PHYS,LAS CRUCES,NM 88003, USA. NR 10 TC 31 Z9 34 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD JUL 20 PY 1996 VL 35 IS 21 BP 4297 EP 4303 DI 10.1364/AO.35.004297 PG 7 WC Optics SC Optics GA VA608 UT WOS:A1996VA60800040 PM 21102839 ER PT J AU Sopok, S AF Sopok, S TI Improved statistical analysis of ion chromatography data from acids for aluminum anodizing solutions SO JOURNAL OF CHROMATOGRAPHY A LA English DT Article; Proceedings Paper CT 8th International Ion Chromatography Symposium CY OCT 01-05, 1995 CL DALLAS, TX DE process monitoring; statistical analysis; sulfuric acid; oxalic acid AB Process monitoring and control of sulfuric and oxalic acids in aluminum anodizing solutions is necessary for producing high quality metal coatings with increased corrosion, wear and abrasion resistance. The production of military armament system parts requires narrow aluminum anodizing solution acid tolerances that increase the need for process monitoring and control. Ion chromatographic analysis is the method of choice used for these military applications. There is significant dispersion in this ion chromatographic data relative to the narrow operating tolerances. An improved ion chromatographic-statistical analysis method reruns/tests data until a specimen's results drop below a dispersion threshold relative to the narrow aluminum anodizing solution acid tolerances. This method provides acceptable process monitoring and statistical control of narrow operating tolerance aluminum anodizing solutions required for high quality military production coatings. The resultant means and improved 95% confident precisions for typical aluminum anodizing solutions are 160.0+/-1.9 g/l of sulfuric acid acid 16.0+/-0.8 g/l of oxalic acid, which are both an improvement by more than a factor of two over simple 95% confident precisions. RP Sopok, S (reprint author), USA,BENET LABS,WATERVLIET,NY 12189, USA. NR 13 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0021-9673 J9 J CHROMATOGR A JI J. Chromatogr. A PD JUL 19 PY 1996 VL 739 IS 1-2 BP 163 EP 166 DI 10.1016/0021-9673(96)00269-5 PG 4 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA UZ355 UT WOS:A1996UZ35500019 ER PT J AU Avery, MA Mehrotra, S Bonk, JD Vroman, JA Goins, DK Miller, R AF Avery, MA Mehrotra, S Bonk, JD Vroman, JA Goins, DK Miller, R TI Structure-activity relationships of the antimalarial agent artemisinin .4. Effect of substitution at C-3 SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID QINGHAOSU ARTEMISININ; (+)-ARTEMISININ; CHEMISTRY; MECHANISM; ANALOGS; INVITRO; DRUG AB Novel antimalarial artemisinin analogs, 3-alkylartemisinins as well as 3-(arylalkyl)- and 3-(carboxyalkyl)artemisinins, were prepared via the synthetic intermediate 2. Formation of the N,N-dimethylhydrazones 5 and 24 and then regio- and chemoselective deprotonation followed by alkylation provided initially alkylated hydrazones that upon chromatography gave ketones 6-13 and 25-30. Direct ozonolysis of the ketones followed by in situ acidification lead directly to the formation of title compounds 14-21 and 31-36. The analogs were tested in vitro against W-2 and D-6 strains of Plasmodium falciparum and found to be in some cases much more active than the natural product (+)-artemisinin. The results were included in structure-activity relationship (CoMFA) studies for further analog design. C1 UNIV MISSISSIPPI,SCH PHARM,PHARMACEUT SCI RES INST,UNIVERSITY,MS 38677. WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. RP Avery, MA (reprint author), UNIV MISSISSIPPI,SCH PHARM,DEPT MED CHEM,UNIVERSITY,MS 38677, USA. NR 29 TC 46 Z9 47 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD JUL 19 PY 1996 VL 39 IS 15 BP 2900 EP 2906 DI 10.1021/jm960200e PG 7 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA UY270 UT WOS:A1996UY27000006 PM 8709124 ER PT J AU Zhang, XY Yao, XT Dalton, JT Shams, G Lei, LP Patil, PN Feller, DR Hsu, FL George, C Miller, DD AF Zhang, XY Yao, XT Dalton, JT Shams, G Lei, LP Patil, PN Feller, DR Hsu, FL George, C Miller, DD TI Medetomidine analogs as alpha 2-adrenergic ligands .2. Design, synthesis, and biological activity of conformationally restricted naphthalene derivatives of medetomidine SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID DEFINED ADRENERGIC AGENTS; RECEPTORS; DEXMEDETOMIDINE; ADRENOCEPTOR; REQUIREMENTS; IMIDAZOLINE; ACTIVATION; AGONISTS; ISOMERS; BINDING AB A new series of naphthalene analogs of medetomidine have been prepared and evaluated for their alpha-adrenergic activities. The methylnaphthyl analog 5a showed significant selectivity for alpha(2)-adrenoceptors and behaved as a partial alpha(1)-agonist in rat aorta preparations. In contrast, the Z-ethylene analog 8c was alpha(1)-selective and behaved as a potent alpha(1)-antagonist. Two rigid analogs (6 and 7) exhibited large differences in binding affinities at alpha(1)- vs alpha(2)-receptors, indicating that the conformational flexibility of 5a is important for the fulfillment of the alpha-adrenergic activities. Molecular modeling studies began with conformational analysis of classical phenethylamines and medetomidine analogs. Superimposition of medetomidine conformations with those of phenethylamines provided a tentative explanation for the alpha(2)-adrenergic activity of the new imidazoles. A common binding mode for phenethylamines and imidazoles with alpha(2)-adrenoceptors is proposed. Knowledge of the biological properties of the 4-substituted imidazoles, integrated with the information derived from computer-assisted molecular modeling, has provided new insights for the structural and conformational requirements of this class as new adrenergic drugs. C1 UNIV TENNESSEE,COLL PHARM,DEPT PHARMACEUT SCI,MEMPHIS,TN 38163. OHIO STATE UNIV,COLL PHARM,DIV MED CHEM & PHARMACOL,COLUMBUS,OH 43210. USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. USN,RES LAB,STRUCT MATTER LAB,WASHINGTON,DC 20375. OI dalton, James T/0000-0002-3915-7326 FU NIGMS NIH HHS [GM-29358-12] NR 41 TC 15 Z9 16 U1 0 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD JUL 19 PY 1996 VL 39 IS 15 BP 3001 EP 3013 DI 10.1021/jm9506074 PG 13 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA UY270 UT WOS:A1996UY27000016 PM 8709134 ER PT J AU Campbell, NF AF Campbell, NF TI Inhibition of the in vitro formation of irreversibly sickled cells using antioxidants. SO BIOCHEMISTRY LA English DT Meeting Abstract C1 UNIV S ALABAMA,USA,CTR COMPREHENS SICKLE CELL,DEPT CHEM,MOBILE,AL 36688. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD JUL 16 PY 1996 VL 35 IS 28 BP 65 EP 65 PG 1 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA UX738 UT WOS:A1996UX73800098 ER PT J AU Do, TM CamposEsteve, MA Berry, MA Rudolphi, RS Gilman, JK AF Do, TM CamposEsteve, MA Berry, MA Rudolphi, RS Gilman, JK TI Pericarditis causing exercise test induced ST-elevations SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Article C1 BROOKE ARMY MED CTR,SERV CARDIOL,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DEPT INTERNAL MED,FT SAM HOUSTON,TX 78234. NR 9 TC 0 Z9 0 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD JUL 15 PY 1996 VL 78 IS 2 BP 251 EP 252 DI 10.1016/S0002-9149(96)90410-5 PG 2 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA UW802 UT WOS:A1996UW80200027 PM 8712157 ER PT J AU Frank, KJ AF Frank, KJ TI Pharmaceutical services in an army field hospital in Haiti during operation uphold democracy SO AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY LA English DT Article DE administration; clinical pharmacy; drug information; formularies; Haiti; patient information; pharmaceutical services; pharmacy, institutional, hospital; United States Army AB The pharmaceutical services provided by an Army field hospital in Haiti during Operation Uphold Democracy are described. In January 1995, 155 soldiers of the 47th Field Hospital from Ft. Sill, Oklahoma, were deployed to Haiti to provide medical care for 2400 U.S. troops and 7000 multi national troops and police officers. The pharmacy staff (one pharmacist and two technicians) provided patient counseling, drug information, staff consultation, and clinical support to the intensive and intermediate care wards and emergency medical tent of the field hospital. Other responsibilities were providing nonprescription drugs to outpatients, interpreting and evaluating drug orders, participating in drug selection, and ordering supplies. A 30- to 60-day drug supply was maintained. The formulary was designed by the pharmacist and an internist and was based on the mission requirements and conditions in Haiti. Of the 10 oral medications most commonly dispensed to outpatients, 6 were antibacterials and 1 was an antimalarial. An average of two patients were admitted to the hospital dally. Some 240 inpatients were recorded in the pharmacy computer during the hospital's six-month deployment, and more than 5000 were treated in the emergency tent. The pharmacy service of the 47th Field Hospital met the challenge of supporting U.S. and multinational troops in Haiti during Operation Uphold Democracy. RP Frank, KJ (reprint author), USA,MED SERV CORP,SERV PHARM,REYNOLDS ARMY COMMUNITY HOSP,FT SILL,OK 73503, USA. NR 2 TC 3 Z9 3 U1 0 U2 0 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 SN 1079-2082 J9 AM J HEALTH-SYST PH JI Am. J. Health-Syst. Pharm. PD JUL 15 PY 1996 VL 53 IS 14 BP 1691 EP 1693 PG 3 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA UY095 UT WOS:A1996UY09500010 PM 8827235 ER PT J AU Mansour, NS Sirenko, YM Kim, KW Littlejohn, MA Stroscio, MA AF Mansour, NS Sirenko, YM Kim, KW Littlejohn, MA Stroscio, MA TI Carrier capture in quantum well embedded quantum wire structures SO APPLIED PHYSICS LETTERS LA English DT Article ID EPITAXY; GROWTH; LASERS AB We propose a novel quantum wire (QWR) laser structure with improved carrier capture characteristics, where the carriers are injected into a quantum well (QWL) and subsequently recombine within an embedded QWR. The corresponding electron capture rates via polar optical phonon scattering are calculated for this system. An oscillatory behavior of the electron capture rate is observed as a function of the QWR thickness at the temperatures considered (77 K and 300 K). The amplitude of these oscillations also increases as the QWR width decreases. Our calculations show that the electron capture rate in the QWL embedded QWR structure can be improved by more than 30% when compared to single QWLs. Therefore, the proposed QWR laser design provides improved modulation bandwidth and optical gain over conventional QWL and QWR structures. (C) 1996 American Institute of Physics. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP Mansour, NS (reprint author), N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695, USA. NR 20 TC 3 Z9 3 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 15 PY 1996 VL 69 IS 3 BP 360 EP 362 DI 10.1063/1.118060 PG 3 WC Physics, Applied SC Physics GA UW820 UT WOS:A1996UW82000026 ER PT J AU Neudeck, PG Fazi, C AF Neudeck, PG Fazi, C TI High-field fast-risetime pulse failures in 4H- and 6H-SiC pn junction diodes SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SILICON-CARBIDE; DEVICES; SI AB We report the observation of anomalous reverse breakdown behavior in moderately doped (2-3x10(17) cm(-3)) small-area micropipe-free 4H- and 6H-SiC pn junction diodes. When measured with a curve tracer, the diodes consistently exhibited very low reverse leakage currents and sharp repeatable breakdown knees in the range of 140-150 V. However, when subjected to single-shot reverse bias pulses (200 ns pulsewidth, 1 ns risetime), the diodes failed catastrophically at pulse voltages of less than 100 V. We propose a possible mechanism for this anomalous reduction in pulsed breakdown voltage relative to de breakdown voltage. This instability must be removed so that SiC high-field devices can operate with the same high reliability as silicon power devices. C1 USA,RES LAB,ADELPHI,MD 20783. RP Neudeck, PG (reprint author), NASA,LEWIS RES CTR,21000 BROOKPK RD,MS 77-1,CLEVELAND,OH 44135, USA. NR 21 TC 24 Z9 24 U1 0 U2 4 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUL 15 PY 1996 VL 80 IS 2 BP 1219 EP 1225 DI 10.1063/1.362922 PG 7 WC Physics, Applied SC Physics GA UX156 UT WOS:A1996UX15600089 ER PT J AU Choi, KK AF Choi, KK TI Reduction of photoconductive gain in quantum well infrared photodetectors SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID NOISE; DETECTORS AB In this work, we show that there is a reduction of photoconductive gain g in quantum well infrared photodetectors from its classical value. The reduction is caused by the quantum nature of electron transport in these structures. On the other hand, the generation-recombination noise is unaffected by the transport model, and remains to be the same as a classical photoconductor. The reduction of g leads to an apparent noise increase in these structures, i.e., the noise gain deduced from the noise measurement is larger than g deduced from the photoconductivity measurements. We compared the present theory with existing experimental data, and found reasonable agreement. (C) 1996 American Institute of Physics. RP Choi, KK (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. RI Choi, Kwong-Kit/K-9205-2013 NR 9 TC 19 Z9 19 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUL 15 PY 1996 VL 80 IS 2 BP 1257 EP 1259 DI 10.1063/1.362868 PG 3 WC Physics, Applied SC Physics GA UX156 UT WOS:A1996UX15600099 ER PT J AU Gretz, JE Kaldjian, EP Anderson, AO Shaw, S AF Gretz, JE Kaldjian, EP Anderson, AO Shaw, S TI Commentary - Sophisticated strategies for information encounter in the lymph node - The reticular network as a conduit of soluble information and a highway for cell traffic SO JOURNAL OF IMMUNOLOGY LA English DT Article ID HIGH ENDOTHELIAL VENULES; RAT; TISSUES; LOCALIZATION; LYMPHOCYTES; EMIGRATION; CYTOKINES; ANTIGEN; PROTEIN; VESSELS AB The lymph node is the crossroad in which soluble signals and cells carried by lymph meet lymphocytes emigrating from blood. Efficient interactions among these elements depend on the reticular network, which comprises reticular fibers, related extracellular matrix components, and associated fibroblastic reticular cells. This network provides a three-dimensional scaffold for attachment of APCs and pathways for the migration of T cells to these APCs. in addition, the network constitutes a miniature conduit system for bulk flow delivery of soluble molecules to distinct sites in the paracortex, particularly the high endothelial venule. The delivered mediators, such as chemokines, regulate the phenotype of the high endothelial venule, the recruitment of lymphocytes, and the behavior of the recruited lymphocytes. Thus, the reticular network is a multifunctional infrastructure that facilitates encounters of cells with other cells and factors necessary for effective and efficient immune surveillance. C1 NCI,HUMAN IMMUNOL SECT,EXPT IMMUNOL BRANCH,NATL INST HLTH,BETHESDA,MD 20892. USA,MED RES INST INFECT DIS,DEPT RESP & MUCOSAL IMMUNOL,FT DETRICK,MD 21702. NR 55 TC 137 Z9 138 U1 1 U2 5 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD JUL 15 PY 1996 VL 157 IS 2 BP 495 EP 499 PG 5 WC Immunology SC Immunology GA UW154 UT WOS:A1996UW15400001 PM 8752893 ER PT J AU Willcox, PJ Gido, SP Muller, W Kaplan, DL AF Willcox, PJ Gido, SP Muller, W Kaplan, DL TI Evidence of a cholesteric liquid crystalline phase in natural silk spinning processes SO MACROMOLECULES LA English DT Article ID FIBROIN AB A look inside the silk spinning process along the length of a silk gland has been achieved by the cryogenic quenching and subsequent microtoming of live silk-spinning animals, Nephila clavipes (spider) and Bombyx mori (silkworm). Observations made using transmission electron microscopy, electron diffraction and atomic force microscopy indicate a cholesteric liquid crystalline phase of aqueous silk fibroin in the early duct portion of the major silk-producing gland in both species. Transmission electron microscopy (TEM) and atomic force microscopy (AFM) provide evidence for the cholesteric intermediate phase. The fracture surface produced by the diamond microtoming knife follows the twist of the director field, yielding thin sections with an undulating surface topography which produces a characteristic banding, on the order of 200-600 nm, in TEM and AFM images. Electron diffraction results also support the picture of the aqueous silk existing as a cholesteric at an intermediate stage in the spinning process. C1 UNIV MASSACHUSETTS,DEPT POLYMER SCI & ENGN,AMHERST,MA 01003. USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. NR 20 TC 81 Z9 84 U1 1 U2 21 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD JUL 15 PY 1996 VL 29 IS 15 BP 5106 EP 5110 DI 10.1021/ma960588n PG 5 WC Polymer Science SC Polymer Science GA UY026 UT WOS:A1996UY02600008 ER PT J AU Chowdhury, DQ Hill, SC Barber, PW AF Chowdhury, DQ Hill, SC Barber, PW TI The morphology dependent resonance does not require discontinuity of the refractive index at the sphere surface - Comment SO OPTICS COMMUNICATIONS LA English DT Article ID RADIALLY INHOMOGENEOUS SPHERES AB The claim of novelty in suggesting that morphology dependent resonances (MDR) does not require a discontinuity is questioned. Previous works showing that MDRs exist even when there is no index discontinuity at the sphere boundary are presented. C1 USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002. UNIV NEVADA,DESERT RES INST,CTR ATMOSPHER SCI,RENO,NV 89506. RP Chowdhury, DQ (reprint author), CORNING INC,CORNING,NY 14831, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD JUL 15 PY 1996 VL 128 IS 4-6 BP 197 EP 198 DI 10.1016/0030-4018(96)00175-7 PG 2 WC Optics SC Optics GA UY524 UT WOS:A1996UY52400002 ER PT J AU Rudin, S Reinecke, TL AF Rudin, S Reinecke, TL TI Scattering of plasmons in a quasi-two-dimensional electron gas containing a fixed-point charge SO PHYSICAL REVIEW B LA English DT Article ID SEMICONDUCTOR QUANTUM-WELLS; COLLECTIVE EXCITATIONS AB We study the scattering of two-dimensional (2D) plasmons by the carrier density nonuniformity created by a charged impurity. The plasmons are described by an integral equation obtained within the hydrodynamic model of the 2D plasma containing a fixed-point charge, We obtain the energy of the scattered plasmons, and evaluate the scattering cross section in the Born approximation. We find that at low energy it varies as the square of the frequency of the incident plasmon. This behavior is markedly different from the three-dimensional plasmon scattering where the scattering cross section goes to a nonzero value at zero momentum. In addition, we employ the random-phase approximation to treat both correlation and finite thickness effects in quantum wells. This allows us to extend these results for the 2D inhomogeneous hydrodynamic model to treat intrasubband plasmons in semiconductor quantum wells. C1 USN, RES LAB, WASHINGTON, DC 20375 USA. MAX PLANCK INST FESTKORPERFORSCH, D-70569 STUTTGART, GERMANY. RP USA, RES LAB, FT MONMOUTH, NJ 07703 USA. NR 14 TC 4 Z9 4 U1 0 U2 0 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9950 EI 2469-9969 J9 PHYS REV B JI Phys. Rev. B PD JUL 15 PY 1996 VL 54 IS 4 BP 2791 EP 2797 DI 10.1103/PhysRevB.54.2791 PG 7 WC Physics, Condensed Matter SC Physics GA VB249 UT WOS:A1996VB24900072 ER PT J AU Huang, Q Ashley, PR AF Huang, Q Ashley, PR TI Achromatic waveguide coupling with a hybrid grating-mirror SO APPLIED OPTICS LA English DT Article DE grating coupler; waveguide grating; achromatic coupler ID DESIGN AB A new grating coupler that incorporates a hybrid grating-mirror is proposed. An analysis of the device indicates that it has a much larger achromatic range than that of conventional grating couplers, as well as a relaxed fabrication requirement for the grating. (C) 1996 Optical Society of America C1 USA,MISSILE COMMAND,CHEM & MAT SCI RES DEV & ENGN CTR,WEAP SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898. NR 5 TC 1 Z9 1 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD JUL 10 PY 1996 VL 35 IS 20 BP 3899 EP 3901 DI 10.1364/AO.35.003899 PG 3 WC Optics SC Optics GA UY819 UT WOS:A1996UY81900017 PM 21102791 ER PT J AU Weir, JP Dacquel, EJ Aronovitz, J AF Weir, JP Dacquel, EJ Aronovitz, J TI Herpesvirus vector-mediated gene delivery to human monocytes SO HUMAN GENE THERAPY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; HUMAN GLUCOCEREBROSIDASE GENE; PLACEBO-CONTROLLED TRIAL; HIV-INFECTION; MONONUCLEAR PHAGOCYTES; DELETION MUTANTS; INTERFERON-ALPHA; BONE-MARROW; TYPE-1; EXPRESSION AB In vitro delivery of interferon-alpha (IFN-alpha) to cultured human monocytes by means of a replication-incompetent herpesvirus vector inhibits human immunodeficiency virus (HIV) replication. To explore the possibility of IFN-alpha gene delivery by vector-infected human monocytes, monocytes were isolated and the culture conditions necessary for efficient vector infection and gene expression were examined. Monocytes were efficiently infected between 1 and 7 days after isolation. Expression of IFN-alpha was greater in cells infected 7 days after isolation compared to 1 day after isolation, but the levels of expression were equivalent regardless of whether cells were maintained in suspension or monolayer culture. When suspension-cultured monocytes were treated with vd120/IFN-alpha and added to monolayer cultures of HIV-infected monocytes, IFN-alpha was expressed and replication of HIV was inhibited. HIV replication was arrested even when HIV had spread through much of the monolayer. The persistence of the viral vector in infected cells was examined by a superinfection rescue assay using a second replication-incompetent herpes simplex virus, 5d/1.2. The initial replication-incompetent vector remained in a recoverable form for at least 7 days after delivery, even though foreign gene expression was transient. C1 US FDA,CTR BIOL EVALUAT & RES,DIV VIRAL PROD,BETHESDA,MD 20892. HENRY M JACKSON FDN,ROCKVILLE,MD 20850. WALTER REED ARMY INST RES,ROCKVILLE,MD 20850. NR 37 TC 6 Z9 6 U1 0 U2 1 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 1043-0342 J9 HUM GENE THER JI Hum. Gene Ther. PD JUL 10 PY 1996 VL 7 IS 11 BP 1331 EP 1338 DI 10.1089/hum.1996.7.11-1331 PG 8 WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research & Experimental Medicine GA WD320 UT WOS:A1996WD32000003 PM 8818720 ER PT J AU Artenstein, AW Ohl, CA VanCott, TC Hegerich, PA Mascola, JR AF Artenstein, AW Ohl, CA VanCott, TC Hegerich, PA Mascola, JR TI Transmission of HIV-1 subtype E in the United States SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter C1 NATL NAVAL MED CTR, BETHESDA, MD USA. HENRY M JACKSON FDN, ROCKVILLE, MD USA. NATL NAVAL MED CTR, ROCKVILLE, MD USA. RP Artenstein, AW (reprint author), WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, WASHINGTON, DC 20307 USA. NR 4 TC 8 Z9 8 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JUL 10 PY 1996 VL 276 IS 2 BP 99 EP 100 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA UV485 UT WOS:A1996UV48500011 PM 8656521 ER PT J AU Nanni, A Ludwig, DA Shoenberger, JE AF Nanni, A Ludwig, DA Shoenberger, JE TI Physico-mechanical properties and load transfer efficiency of RCC pavement SO ACI MATERIALS JOURNAL LA English DT Article DE cracking; density; joints; load transfer; roller-compacted concrete (RCC); rolling; strength; vibratory hammer; weight AB In an RCC demonstration project that considered of a 1525-ft-(465-m)-long roadway and a 100 x 39-ft (30 x 12-m) parking lot, the effect of several construction parameters on physico-mechanical properties of the pavement and the load transfer efficiency at its joints and cracks were investigated. This paper reports experimental results on lay-down and final densities as affected by paver speed and rolling pattern, the strength of laboratory-made specimens using the vibratory hammer method as a function of mixes with slightly different aggregate gradations, cracking patterns at 7 months from construction as affected by saw-cut joint spacing, and load transfer efficiency at natural cracks and saw-cut joints. Overall, the results fall within the expectations of the program and confirm the suitability of current construction practices for RCC paving applications. C1 MCSHERRY GRP,W ALLIS,WI. USA,CORPS ENGINEERS,WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP Nanni, A (reprint author), PENN STATE UNIV,104 DAVEY LAB,UNIVERSITY PK,PA 16802, USA. OI Nanni, Antonio/0000-0003-2678-9268 NR 5 TC 0 Z9 0 U1 0 U2 0 PU AMER CONCRETE INST PI FARMINGTON HILLS PA 38800 INTERNATIONAL WAY, COUNTRY CLUB DRIVE, PO BOX 9094, FARMINGTON HILLS, MI 48333-9094 SN 0889-325X J9 ACI MATER J JI ACI Mater. J. PD JUL-AUG PY 1996 VL 93 IS 4 BP 356 EP 361 PG 6 WC Construction & Building Technology; Materials Science, Multidisciplinary SC Construction & Building Technology; Materials Science GA VC692 UT WOS:A1996VC69200007 ER PT J AU Stevens, JB Vories, PA Walker, SC AF Stevens, JB Vories, PA Walker, SC TI Nebulized tetracaine attenuates the hemodynamic response to tracheal intubation SO ACTA ANAESTHESIOLOGICA SCANDINAVICA LA English DT Article DE local anesthetics, lidocaine, tetracaine; nebulization; intubation ID CIRCULATORY RESPONSES; INTRAVENOUS LIDOCAINE; LARYNGOSCOPY; ANESTHESIA; DURATION AB Background: Local anesthetics, principally lidocaine, are commonly administered in an attempt to blunt the hemodynamic response to tracheal intubation. There are no prior investigations evaluating the use of tetracaine in this setting. Methods: In the present study, 30 female patients (ASA I-II) scheduled for elective surgery were randomized to receive inhaled nebulized tetracaine 0.5 mg/kg or nebulized saline. Subsequently, anesthesia was induced with thiopental 5 mg/kg and succinylcholine 1.0 mg/kg. Sixty seconds later, the trachea was intubated. Vital signs were recorded at intubation and at 1-minute intervals for the next 5 minutes. Results: Patients treated with tetracaine had a significantly (P<0.05) lower mean heart rate at intubation and all subsequent times. Similarly, there were significant differences (P<0.05) in mean arterial pressure between tetracaine and control patients at all times post-intubation except at 2 minutes. The inhalation of nebulized tetracaine produced no adverse side effects. Conclusion: We conclude that nebulized tetracaine significantly attenuates the hemodynamic response to tracheal intubation. C1 BROOKE ARMY MED CTR,ANESTHESIOL SERV,SAN ANTONIO,TX. NR 12 TC 1 Z9 1 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0001-5172 J9 ACTA ANAESTH SCAND JI Acta Anaesthesiol. Scand. PD JUL PY 1996 VL 40 IS 6 BP 757 EP 759 PG 3 WC Anesthesiology SC Anesthesiology GA UX869 UT WOS:A1996UX86900021 PM 8836275 ER PT J AU Wright, MJ Candler, GV Prampolini, M AF Wright, MJ Candler, GV Prampolini, M TI Data-parallel lower-upper relaxation method for the Navier-Stokes equations SO AIAA JOURNAL LA English DT Article AB The lower-upper symmetric Gauss-Seidel method is modified for the simulation of viscous flows on massively parallel computers. The resulting diagonal data-parallel lower-upper relaxation (DP-LUR) method is shown to have good convergence properties on many problems. However, the convergence rate decreases on the high cell aspect ratio grids required to simulate high Reynolds number hows. Therefore, the diagonal approximation is relaxed, and a full matrix version of the DP-LUR method is derived. The full matrix method retains the data-parallel properties of the original and reduces the sensitivity of the convergence rate to the aspect ratio of the computational grid. Both methods are implemented on the Thinking Machines CM-5, and a large fraction of the peak theoretical performance of the machine is obtained, The low memory use and high parallel efficiency of the methods make them attractive for large-scale simulation of viscous flows. C1 UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. RP Wright, MJ (reprint author), UNIV MINNESOTA,DEPT AEROSP ENGN & MECH,MINNEAPOLIS,MN 55455, USA. NR 15 TC 32 Z9 35 U1 1 U2 4 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0001-1452 J9 AIAA J JI AIAA J. PD JUL PY 1996 VL 34 IS 7 BP 1371 EP 1377 DI 10.2514/3.13242 PG 7 WC Engineering, Aerospace SC Engineering GA UV574 UT WOS:A1996UV57400008 ER PT J AU Pritchard, JI Adelman, HM SobieszczanskiSobieski, J AF Pritchard, JI Adelman, HM SobieszczanskiSobieski, J TI Optimization for minimum sensitivity to uncertain parameters SO AIAA JOURNAL LA English DT Article ID OPTIMAL-DESIGN AB A procedure to design a structure for minimum sensitivity to uncertainties in problem parameters is described. The approach is to directly minimize the sensitivity derivatives of the optimum design with respect to fixed design parameters using a nested optimization procedure, The procedure is demonstrated for the design of a bimetallic beam for minimum weight with insensitivity to uncertainties in structural properties, The beam is modeled with finite elements based on two-dimensional beam analysis, A sequential quadratic programming procedure used as the optimizer supplies the Lagrange multipliers that are used to calculate the optimum sensitivity derivatives. The procedure is validated by comparing the optimization results to parametric studies. C1 NASA,LANGLEY RES CTR,STRUCT DYNAM BRANCH,HAMPTON,VA 23681. NASA,LANGLEY RES CTR,STRUCT DIV,HAMPTON,VA 23681. RP Pritchard, JI (reprint author), NASA,LANGLEY RES CTR,VEHICLE STRUCT DIRECTORATE,ARMY RES LAB,HAMPTON,VA 23681, USA. NR 16 TC 2 Z9 2 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0001-1452 J9 AIAA J JI AIAA J. PD JUL PY 1996 VL 34 IS 7 BP 1501 EP 1504 DI 10.2514/3.13259 PG 4 WC Engineering, Aerospace SC Engineering GA UV574 UT WOS:A1996UV57400025 ER PT J AU Tzeng, JT Chien, LS AF Tzeng, JT Chien, LS TI Viscoelastic analysis of thick-walled filament-wound composite cylinders with elevated temperatures SO AIAA JOURNAL LA English DT Article RP Tzeng, JT (reprint author), USA,RES LAB,WEAP TECHNOL DIRECTORATE,ABERDEEN PROVING GROUND,MD 21005, USA. NR 11 TC 0 Z9 0 U1 1 U2 1 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0001-1452 J9 AIAA J JI AIAA J. PD JUL PY 1996 VL 34 IS 7 BP 1526 EP 1529 DI 10.2514/3.13264 PG 4 WC Engineering, Aerospace SC Engineering GA UV574 UT WOS:A1996UV57400029 ER PT J AU Kerle, KK Nishimura, KD AF Kerle, KK Nishimura, KD TI Exertional collapse and sudden death associated with sickle cell trait SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID ACUTE-RENAL-FAILURE; RISK FACTOR; RHABDOMYOLYSIS; EXERCISE AB Although rare, exertional collapse and sudden death are the most serious potential complications of sickle cell trait. Studies suggest that this condition may occur in susceptible persons when poor physical conditioning, dehydration, heat stress or hypoxic states precipitate sickling of the abnormal erythrocytes. Sickling leads to endothelial damage, which can cause vasoconstriction, disseminated intravascular coagulation and local tissue damage. Cardiac effects include acute ischemia and arrhythmias. Muscle damage results in acute compartment syndromes and release of myoglobin into the circulation. Acute renal failure is possible. Diagnosis is based on a high index of suspicion, and characteristic presentation and laboratory findings, including myoglobinuria, hyperkalemia, hypocalcemia, hyperphosphatemia and elevated creatine kinase levels. The differential diagnosis includes pulmonary embolism, acute cardiac events, anaphylaxis and heat stroke. Management is based on stabilization, rehydration, and the treatment and prevention of complications. RP Kerle, KK (reprint author), USA,MARTIN ARMY COMMUNITY HOSP,FAMILY PRACTICE RESIDENCY,FT BENNING,GA 31905, USA. NR 22 TC 32 Z9 34 U1 0 U2 1 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD JUL PY 1996 VL 54 IS 1 BP 237 EP 240 PG 4 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA UW459 UT WOS:A1996UW45900028 PM 8677839 ER PT J AU Smith, SR Steinberg, S Gaydos, JC AF Smith, SR Steinberg, S Gaydos, JC TI Errors in derivations of the Coburn-Forster-Kane equation for predicting carboxyhemoglobin SO AMERICAN INDUSTRIAL HYGIENE ASSOCIATION JOURNAL LA English DT Article DE carboxyhemoglobin; Coburn-Forster-Kane equation; military medicine ID CARBON-MONOXIDE AB An error identified in a 1993 textbook of military medicine led to an investigation of derivations of the Coburn-Forster-Kane equation (CFKE) for predicting carboxyhemoglobin (COHb) levels. Reviews of the scientific literature, military documents, and personal interviews revealed that errors were made in earlier derivations of the CFKE. One flawed derivation was used by the U.S. Army until 1985, and another is still used by the National Institute for Occupational Safety and Health (NIOSH). The original and later CFKE derivations are reviewed and errors in the equations are identified. The effect of the errors is discussed. C1 USA,ABERDEEN TEST CTR,ABERDEEN PROVING GROUND,MD. RP Smith, SR (reprint author), USA,CTR HLTH PROMOT & PREVENT MED,EDGEWOOD AREA,ABERDEEN PROVING GROUND,MD 21010, USA. NR 28 TC 11 Z9 11 U1 0 U2 0 PU AMER INDUSTRIAL HYGIENE ASSOC PI FAIRFAX PA 2700 PROSPERITY AVE #250, FAIRFAX, VA 22031-4307 SN 0002-8894 J9 AM IND HYG ASSOC J JI Am. Ind. Hyg. Assoc. J. PD JUL PY 1996 VL 57 IS 7 BP 621 EP 625 DI 10.1202/0002-8894(1996)057<0621:EIDOTC>2.0.CO;2 PG 5 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA UW928 UT WOS:A1996UW92800005 PM 8686658 ER PT J AU Gordon, DM Duffy, PE Heppner, DG Lyon, JA Williams, JS Scheumann, D Farley, L Stacey, D Haynes, JD Sadoff, JC Ballou, WR AF Gordon, DM Duffy, PE Heppner, DG Lyon, JA Williams, JS Scheumann, D Farley, L Stacey, D Haynes, JD Sadoff, JC Ballou, WR TI Phase I safety and immunogenicity testing of clinical lots of the synthetic Plasmodium falciparum vaccine SPF66 produced under good manufacturing procedure conditions in the United States SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID FIELD TRIALS; MALARIA; CHILDREN AB Two clinical lots of alum-adsorbed SPf66 vaccine produced in the United States were evaluated in separate, open-label, Phase I clinical trials involving 15 healthy, malaria-naive, 18-45-year old men and women. Subjects received 2 mg doses subcutaneously in alternate arms at 0, one, and six months, Safety was assessed by monitoring local and systemic reactions and laboratory parameters. The most common side effects were erythema and local tenderness at the site of injection, which increased in frequency with subsequent doses of vaccine. These local reactions were considered mild and resolved within 24-48 hr. Eleven of 14 volunteers who received all three doses of vaccine seroconverted by enzyme-linked immunosorbent assay. The distribution of high, medium, and low nonresponders was comparable with that seen in trials of Colombian-produced vaccine. One high responder developed antibodies reactive with asexual stage parasite antigens by immunofluorescence and immunoblot. The results indicated that at full adult doses, SPf66 of U.S. origin is mildly reactogenic and induces immune responses similar to those reported for SPf66 of Colombian origin. C1 WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307. NR 16 TC 11 Z9 12 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 1996 VL 55 IS 1 BP 63 EP 68 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA VA963 UT WOS:A1996VA96300011 PM 8702024 ER PT J AU Hall, WC Geisbert, TW Huggins, JW Jahrling, PB AF Hall, WC Geisbert, TW Huggins, JW Jahrling, PB TI Experimental infection of guinea pigs with Venezuelan hemorrhagic fever virus (Guanarito): A model of human disease SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID RODENT RESERVOIR; PATHOGENESIS; RIBAVIRIN; MONKEYS; ANTIGEN; TISSUE; LIVER AB Venezuelan hemorrhagic fever (VHF), a newly described disease caused by an arenavirus (Guanarito), has resulted in multiple human deaths in Venezuela. To develop an animal model of this disease, strain 13 and Hartley strain guinea pigs were inoculated subcutaneously with Guananto strain 95551 of arenavirus in a pilot study to determine susceptibility of the species to the virus. All animals were killed when moribund 12-14 days following inoculation. Animals were necropsied and tissues were fixed and examined by both light and electron microscopy. Viral antigen was demonstrated in the tissues by immunohistochemistry at both the light and electron microscopic levels. Lesions were characterized by single cell necrosis of epithelium of the gastrointestinal tract, interstitial pneumonia, lymphoid and hematopoietic cell necrosis, and the presence of platelet thrombi in occasional blood vessels associated with hemorrhage. Viral antigen was demonstrated in lymphoid tissues and macrophages, endothelial cells of multiple organs, pulmonary epithelium epithelium of the gastrointestinal tract, and in miscellaneous other tissues and cells. Intact virions and typical arenavirus inclusions were demonstrated by immunoelectron microscopy in these tissues. Based on these findings, the guinea pig appears to be a valid animal model of the human disease. C1 USA,MED RES INST INFECT DIS,DIV PATHOL,FREDERICK,MD 21702. USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21701. USA,MED RES INST INFECT DIS,HQ,FREDERICK,MD. NR 18 TC 20 Z9 20 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 1996 VL 55 IS 1 BP 81 EP 88 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA VA963 UT WOS:A1996VA96300014 PM 8702027 ER PT J AU Turell, MJ Bressler, DS Rossi, CA AF Turell, MJ Bressler, DS Rossi, CA TI Short report: Lack of virus replication in arthropods after intrathoracic inoculation of Ebola Reston virus SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MOSQUITOS AB To evaluate the potential for arthropods to serve as reservoir hosts of Ebola virus, three mosquito species, Aedes albopictus, Aedes taeniorhynchus, and Culex pipiens, and a soft tick, Ornithodoros sonrai, were inoculated with 10(2.5) plaque-forming units of Ebola Reston virus. After incubation at 22 degrees C for 11 days, at least six specimens of each species were triturated and examined for evidence of viral replication by enzyme-linked immunosorbent assay and plaque assay. There was no evidence of viral replication in any of the arthropods tested, Because intrathoracic inoculation bypasses various barriers to viral infection, the lack of replication of Ebola Reston virus in these inoculated arthropods indicates that these mosquito species and soft ticks probably are not involved as natural reservoirs of Ebola virus. RP Turell, MJ (reprint author), USA,MED RES INST INFECT DIS,VECTOR ASSESSMENT BRANCH,DIAGNOST SYST DIV,FT DETRICK,FREDERICK,MD 21702, USA. NR 11 TC 21 Z9 22 U1 1 U2 7 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 1996 VL 55 IS 1 BP 89 EP 90 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA VA963 UT WOS:A1996VA96300015 PM 8702028 ER PT J AU Shih, ML Korte, WD AF Shih, ML Korte, WD TI Analysis of hemoglobin derivatives by capillary isoelectric focusing and its application in the antidotal research of cyanide poisoning SO ANALYTICAL BIOCHEMISTRY LA English DT Article ID MULTICOMPONENT ANALYSIS; MECHANISM; OXIDATION; VARIANTS; NITRITE AB Cyanide toxicity can be reduced by the use of methemoglobin (MetHb) formers, and antidotal dosage is based on the extent of MetHb formation. Hemoglobin and ferrihemoglobin (MetHb, hemimethemoglobins) alpha(2+)beta(3+) and (alpha(2+)beta(3+), tetracyanmethemoglobin, and dicyanmethemoglobin) concentrations in human, pig, and mouse blood were determined after separation by isoelectric focusing with an octyl-bonded capillary. The predominant species formed in blood when MetHb formers, such as potassium ferricyanide, hydroxylamine, sodium nitrite, and 4-dimethylaminophenol (DMAP), added at molar ratios ranging from 1:10 to 1:1 to hemoglobin, are the valency hybrid intermediates alpha(3+)beta(2+) and alpha(2+)beta(3+). In the detoxification of cyanide with methemoglobin, an intermediate dicyanhemimethemoglobin was demonstrated to be the predominant species in the formation of tetracyanmethemoglobin. Complex mixtures of hemoglobin derivatives were observed with DMAP at 1:1 or greater molar ratio to hemoglobin. Comparison of the MetHb values obtained with a hemoxometer indicated that the valency hybrids were measured as MetHb and the values of oxidized hemoglobin were overestimated. In cyanide poisoning, incorrect dosages of MetHb formers could be calculated, and misinterpretation of MetHb data would result from methods that fail to discriminate among the various species of MetHb. (C) 1996 Academic Press, Inc. RP Shih, ML (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 24 TC 10 Z9 11 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0003-2697 J9 ANAL BIOCHEM JI Anal. Biochem. PD JUL 1 PY 1996 VL 238 IS 2 BP 137 EP 144 DI 10.1006/abio.1996.0266 PG 8 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA UW720 UT WOS:A1996UW72000005 PM 8660602 ER PT J AU Swide, CE Nyberg, PF AF Swide, CE Nyberg, PF TI Cardiac trauma: An unusual cause of dysrhythmias and electrocardiographic changes during laparoscopic nissen fundoplication SO ANESTHESIOLOGY LA English DT Article DE surgery; laparoscopy; Nissen fundoplication; complications; cardiac trauma; dysrhythmias ID CHOLECYSTECTOMY C1 USA,DARNALL ARMY HOSP,FT HOOD,TX. RP Swide, CE (reprint author), OREGON HLTH SCI UNIV,PORTLAND,OR 97201, USA. NR 6 TC 6 Z9 6 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD JUL PY 1996 VL 85 IS 1 BP 209 EP 211 DI 10.1097/00000542-199607000-00027 PG 3 WC Anesthesiology SC Anesthesiology GA UW186 UT WOS:A1996UW18600029 PM 8694367 ER PT J AU Eckhardt, SG Burris, HA Eckardt, JR Weiss, G Rodriguez, G Rothenberg, M Rinaldi, D Barrington, R Kuhn, JG Masuo, K Sudo, K Atsumi, R Oguma, T Higashi, L Fields, S Smetzer, L VonHoff, DD AF Eckhardt, SG Burris, HA Eckardt, JR Weiss, G Rodriguez, G Rothenberg, M Rinaldi, D Barrington, R Kuhn, JG Masuo, K Sudo, K Atsumi, R Oguma, T Higashi, L Fields, S Smetzer, L VonHoff, DD TI A phase I clinical and pharmacokinetic study of the angiogenesis inhibitor, tecogalan sodium SO ANNALS OF ONCOLOGY LA English DT Article DE angiogenesis inhibitors; investigational agents; sulfated polysaccharides ID POLYSACCHARIDE-PEPTIDOGLYCAN COMPLEX; TUMOR-GROWTH; COMBINATION; METASTASIS; AGENTS AB Background: Tecogalan sodium is an angiogenesis inhibitor isolated from a sulfated polysaccharide produced by the bacterium Arthrobacter. The antiangiogenic effect of tecogalan sodium is thought to be mediated by the inhibition of binding of basic fibroblast growth factor to cellular receptors. Patients and methods: A phase I study was conducted in thirty-three patients with refractory malignancies, including AIDS-associated Kaposi's sarcoma. Patients received a single i.v. infusion every three weeks with the infusion duration ranging from one to twenty-four hours. Seven different dosage levels were studied (125, 185, 240, 300, 390, 445, and 500 mg/m(2)). Results: The primary dose-limiting toxicity was prolongation of the activated partial thromboplastin time with peak times being between 1.0-4.0 times the upper limit of normal. This toxicity was ameliorated at a given dose level by prolonging the infusion time. Other common toxicities included fever (40%) and rigors (31%) which were well controlled with acetominophen and meperidine. The serum half-life of tecogalan sodium was between 1-1.5 hours and <25% of unchanged drug was excreted in the urine. Conclusions: The recommended phase II dose of tecogalan sodium on this schedule is 390 mg/m(2) over 24 hours. Other schedules including continuous administration should be investigated to maximize the efficacy of this novel angiogenesis inhibitor. C1 UNIV TEXAS,HLTH SCI CTR,DEPT MED,DIV ONCOL,SAN ANTONIO,TX 78229. BROOKE ARMY MED CTR,SAN ANTONIO,TX. DAIICHI PHARMACEUT CORP,FT LEE,NJ. DAIICHI PHARMACEUT CORP,TOKYO,JAPAN. RP Eckhardt, SG (reprint author), UNIV TEXAS,HLTH SCI CTR,CANC THERAPY & RES CTR,8122 DATAPOINT DR,SUITE 700,SAN ANTONIO,TX 78229, USA. NR 15 TC 33 Z9 33 U1 0 U2 3 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0923-7534 J9 ANN ONCOL JI Ann. Oncol. PD JUL PY 1996 VL 7 IS 5 BP 491 EP 496 PG 6 WC Oncology SC Oncology GA UZ988 UT WOS:A1996UZ98800017 PM 8839904 ER PT J AU Hetherington, HE Hollinger, JO Morris, MR Panje, WR AF Hetherington, HE Hollinger, JO Morris, MR Panje, WR TI Onlay bone augmentation with an osteoinductive implant SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE bone graft; osteoconduction; osteoinduction ID EXTRACELLULAR-MATRIX; DEMINERALIZED BONE; ENDOCHONDRAL BONE; TRANSPLANTATION; RECONSTRUCTION; CHROMATOGRAPHY; CARTILAGE; SURGERY; PROTEIN; BOVINE AB The repair of contour defects of craniofacial bone can be accomplished by several methods, including autogenous bone grafts, demineralized bone, and alloplastic materials. The objective of this study was to assess a biodegradable, xenogeneic, osteoinductive implant for craniofacial onlay bone augmentation. Twelve New Zealand White rabbits each had craniofacial onlays consisting of three experimental materials: 1) autograft; 2) allogeneic, demineralized block implant; and 3) partially purified osteoinductive protein (osteogenin) with allogeneic collagen and 50:50 poly(DL-lactide-co-glycolide). Implants with host bone were recovered after 20 weeks and assessed by histomorphometric methods. There was no evidence of adverse local reaction to the three treatments, No significant difference in bone replacement or bone density resulting from each of the implant types was demonstrated. In conclusion, the osteoinductive implants were well tolerated, and over the 20-week period they appeared to maintain their contour as onlays. C1 MADIGAN ARMY MED CTR,OTOLARYNGOL SERV,TACOMA,WA 98431. USA,WALTER REED ARMY MED CTR,DENT RES INST,WASHINGTON,DC 20310. RUSH PRESBYTERIAN ST LUKES MED CTR,DEPT OTOLARYNGOL & BRONCHOESOPHAGOL,CHICAGO,IL 60612. NR 28 TC 1 Z9 1 U1 0 U2 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 1996 VL 105 IS 7 BP 568 EP 573 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA UX722 UT WOS:A1996UX72200014 PM 8678436 ER PT J AU Kondratieff, BC Kirchner, RF AF Kondratieff, BC Kirchner, RF TI Two new species of Hansonoperla (Plecoptera: Perlidae) from eastern North America SO ANNALS OF THE ENTOMOLOGICAL SOCIETY OF AMERICA LA English DT Article DE Hansonoperla; new species; Nearctic region; Alabama; Kentucky West Virginia ID STONEFLIES PLECOPTERA; RECORDS AB Two new species are added to the eastern Nearctic genus Hansonoperla, which included only H. appalachia Nelson. Hansonoperla hokolesqua n. sp. is described from northeastern Kentucky and southwestern West Virginia, and H. cheaha n. sp. from northeastern Alabama. All 3 species are described from the adult male, adult female, and the egg. Diagnostic features and a key for separating the 3 species are presented, supported by illustrations and scanning electron microscopy photomicrographs. C1 USA,HUNTINGTON DIST CORPS ENGINEERS,WATER QUAL SECT,HUNTINGTON,WV 25701. RP Kondratieff, BC (reprint author), COLORADO STATE UNIV,DEPT ENTOMOL,FT COLLINS,CO 80523, USA. NR 7 TC 1 Z9 3 U1 0 U2 0 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0013-8746 J9 ANN ENTOMOL SOC AM JI Ann. Entomol. Soc. Am. PD JUL PY 1996 VL 89 IS 4 BP 501 EP 509 PG 9 WC Entomology SC Entomology GA UX707 UT WOS:A1996UX70700002 ER PT J AU Krivda, SJ Roy, MJ James, WD AF Krivda, SJ Roy, MJ James, WD TI Cutaneous findings in Gulf War veterans SO ARCHIVES OF DERMATOLOGY LA English DT Article C1 HOSP UNIV PENN,DEPT DERMATOL,PHILADELPHIA,PA 19104. USA,HEIDELBERG,GERMANY. USA,WASHINGTON,DC 20310. NR 4 TC 3 Z9 3 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD JUL PY 1996 VL 132 IS 7 BP 846 EP 847 DI 10.1001/archderm.132.7.846 PG 2 WC Dermatology SC Dermatology GA UY339 UT WOS:A1996UY33900030 PM 8678592 ER PT J AU Peck, L AF Peck, L TI Temporal and spatial fluctuations in ground cover surface temperature at a northern New England site SO ATMOSPHERIC RESEARCH LA English DT Article ID REGIONAL EVAPOTRANSPIRATION; MOISTURE; SIMULATION; SNOW AB Ground cover surface temperature at a field site in South Royalton, Vermont, is calculated from 30-minute averages of upwelling longwave (3-50 mu m) radiation measured with a pyrgeometer, resulting in 48 estimations of surface temperature each day. The ground covers are a seasonal sequence of (1) dormant grass prior to snowfall, (2) snow cover, (3) an irregular distribution of thatch, exposed soil and new-growth grass following final snowmelt and (4) lush, continuous grass cover. Diurnal variation in ground cover surface temperature and also seasonal differences in temperature spread and rate of temperature change are evident. Daily ranges (maximum-minimum) in ground cover surface temperature are 9-13 degrees C (dormant grass), 1-12 degrees C (midwinter snow cover), 22-25 degrees C (late winter snow cover), 21-45 degrees C (grass-thatch-soil), and 23-37 degrees C (lush grass). The associated maximum rates of change of ground cover surface temperature are 5 degrees C/h, 3 degrees C/h, 10 degrees C/h, 20 degrees C/h and 10 degrees C/h, respectively. An indication of relative spatial uniformity of surface temperature for these ground covers is obtained by monitoring the surface with a second instrument, a passive infrared sensor system that responds to differential changes in thermal radiance from the ground cover. The snow cover is a thermally uniform background (on the scale of field of view of the passive infrared sensor system), and the grass-thatch-soil is thermally the most diverse, while the lush grass is thermally heterogeneous when sunlit grass blades blow in the wind. The use of such a passive infrared sensor system provides information on the variability of ground cover surface temperature, and by implication, on changes in radiant-energy loading and heat exchange processes, on a spatial scale larger than that of a standard ground-based pyrgeometer. RP Peck, L (reprint author), USA, COLD REG RES & ENGN LAB, 72 LYME RD, HANOVER, NH 03755 USA. NR 22 TC 5 Z9 5 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0169-8095 J9 ATMOS RES JI Atmos. Res. PD JUL PY 1996 VL 41 IS 2 BP 131 EP 160 DI 10.1016/0169-8095(95)00043-7 PG 30 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA VA820 UT WOS:A1996VA82000003 ER PT J AU Lee, T Pham, MQ Weigand, WA Harvey, SP Bentley, WE AF Lee, T Pham, MQ Weigand, WA Harvey, SP Bentley, WE TI Bioreactor strategies for the treatment of growth-inhibitory waste: An analysis of thiodiglycol degradation, the main hydrolysis product of sulfur mustard SO BIOTECHNOLOGY PROGRESS LA English DT Article AB The microbial degradation of thiodiglycol, the primary hydrolysis product of sulfur mustard, by a pure culture of Alcaligenes xylosoxydans ssp. xylosoxydans (SH91) was accomplished in laboratory scale stirred tank reactors. This is a major component of the overall biodegradation process proposed for the complete mineralization of sulfur mustard. Several configurations were evaluated for degradation efficiency including batch, repeated batch, continuous stirred tank reactor (CSTR), and two-stage series CSTR. The repeated batch reactor provided the highest degradation rate of thiodiglycol. Further, this method degraded thiodiglycol in the liquid broth to below the detection limits (0.03 mM). Both batch and repeated batch experiments were simulated by an unstructured mathematical model. Simulation results were in agreement with the experimental data, particularly at low TDG concentration (around 30 mM). This study demonstrates the degradation of thiodiglycol using bioreactors and, more generally, is an experimental study of bioreactor designs for the degradation of growth-inhibitory substances. C1 UNIV MARYLAND,INST BIOTECHNOL,CTR AGR BIOTECHNOL,COLLEGE PK,MD 20742. UNIV MARYLAND,DEPT CHEM ENGN,COLLEGE PK,MD 20742. USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. NR 16 TC 21 Z9 23 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 8756-7938 J9 BIOTECHNOL PROGR JI Biotechnol. Prog. PD JUL-AUG PY 1996 VL 12 IS 4 BP 533 EP 539 DI 10.1021/bp9600290 PG 7 WC Biotechnology & Applied Microbiology; Food Science & Technology SC Biotechnology & Applied Microbiology; Food Science & Technology GA VB391 UT WOS:A1996VB39100015 PM 8987480 ER PT J AU Kaushal, S LaRussa, VF Gartner, S Kessler, S Perfetto, S Yu, Z Ritchey, DW Xu, J Perera, P Kim, J Reid, T Mayers, DL StLouis, D Mosca, JD AF Kaushal, S LaRussa, VF Gartner, S Kessler, S Perfetto, S Yu, Z Ritchey, DW Xu, J Perera, P Kim, J Reid, T Mayers, DL StLouis, D Mosca, JD TI Exposure of human CD34(+) cells to human immunodeficiency virus type 1 does not influence their expansion and proliferation of hematopoietic progenitors in vitro SO BLOOD LA English DT Article ID HUMAN-BONE-MARROW; IMMUNE-DEFICIENCY SYNDROME; PERIPHERAL-BLOOD; INVITRO GROWTH; STEM-CELLS; INFECTION; REPLICATION; HIV-1; ABNORMALITIES; INDIVIDUALS AB The susceptibility of highly purified human CD34(+) cells to monocytotropic (Ba-L) and lymphotropic (AO18-post) strains of human immunodeficiency virus-1 (HIV-1) was examined. Liquid cultures initiated with fresh immunomagnetically purified CD34(+) cells using the K6.1 CD34 monoclonal antibody (MoAb) (K6.1/CD34(+)) were positive for HIV expression 2 weeks after exposure to HIV-1 Ba-L. These cells were initially greater than 90% CD34(+) and had undetectable monocyte contamination by flow-cytometric staining and side-scatter analyses, respectively, and undetectable T-cell contamination by CD3 polymerase chain reaction (PCR) analysis. However, secondary CD34(+) liquid cultures reselected from the primary liquid cultures 24 hours after HIV exposure by panning with the ICH3 CD34 MoAb (ICH3/CD34(+)) and maintained for an additional 14 days were negative for HIV expression. The ICH3-unbound cells were positive for both spliced and unspliced HIV RNA when exposed to HIV-1 Ba-L, and were DNA PCR positive when exposed to either monocytotropic or lymphotropic HIV-1. To further test that CD34(+) cells were not infectible by HIV-1, we exposed K6.1/CD34(+) cells continuously to HIV-1 in a culture system capable of maintaining and expanding primitive CD34(+) cells. HIV-exposed K6.1/CD34(+) cells proliferated and expanded as efficiently as uninfected cultures. However, when reselected magnetically using the K6.1 CD34 MoAb after expansion for 7 days, bound K6.1/CD34(+) cells were again negative for HIV-1 expression, whereas unbound cells were positive for HIV-1 expression. These findings suggest that a sequential CD34(+) cell-selection process, in which the two selections are separated by a brief culture period, can yield a population of CD34(+) cells that are not infected with HIV-1. This process may be useful in the design of stem or progenitor cell-based transplantation therapies for HIV infection. (C) 1996 by The American Society of Hematology. C1 WALTER REED ARMY INST RES,HENRY M JACKSON FDN ADV MIL MED,WASHINGTON,DC. WALTER REED ARMY INST RES,DEPT HEMATOL & VASC BIOL,WASHINGTON,DC. MIL MED CONSORTIUM APPL RETROVIRAL RES,ROCKVILLE,MD. NIAID,NATL INST HLTH,BETHESDA,MD 20892. NR 35 TC 20 Z9 20 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD JUL 1 PY 1996 VL 88 IS 1 BP 130 EP 137 PG 8 WC Hematology SC Hematology GA UV297 UT WOS:A1996UV29700014 PM 8704167 ER PT J AU Walsh, DS Pattanapanyasat, K Lamchiagdhase, P Siritongtaworn, P Thavichaigarn, P Jiarakul, N Chuntrasakul, C Komoltri, C Dheeradhada, C Pearce, FC Wisemann, WP Webster, HK AF Walsh, DS Pattanapanyasat, K Lamchiagdhase, P Siritongtaworn, P Thavichaigarn, P Jiarakul, N Chuntrasakul, C Komoltri, C Dheeradhada, C Pearce, FC Wisemann, WP Webster, HK TI Iron status following trauma, excluding burns SO BRITISH JOURNAL OF SURGERY LA English DT Article ID INFECTION; DEFENSE; TRANSFERRIN; METABOLISM; EXPRESSION AB Serum concentration of iron, transferrin saturation and total iron binding capacity (TIBC) were measured on days 1, 2, 3, 5, 7, 10 and 13 in 36 Thai patients with trauma (burns excluded) to determine temporal changes in iron metabolism. Throughout the study profound hypoferraemia was observed in association with decreased transferrin saturation. TIBC, in contrast, did not differ significantly from that in controls. These findings confirm previous reports which describe altered iron metabolism in association with an adverse event, a response known as 'stress hypoferraemia', and extends these observations to non-burned patients with trauma. The degree of hypoferraemia in patients in this study was not related to sepsis, Injury Severity Score, volume of blood transfused or surgery, suggesting that hypoferraemia following trauma is an independent event. The recognition of rapid and prolonged iron sequestration provides insight into the clinical condition of patients with trauma. C1 WALTER REED ARMY INST RES,DIV SURG,WASHINGTON,DC. ARMED FORCES RES INST MED SCI,USA COMPONENT,DEPT IMMUNOL & BIOCHEM,BANGKOK,THAILAND. SIRIRAJ HOSP,DIV HEMATOL,THALASSEMIA CTR,BANGKOK,THAILAND. MAHIDOL UNIV,FAC MED TECHNOL,DEPT CLIN MICROSCOPY,BANGKOK 10700,THAILAND. MAHIDOL UNIV,SIRIRAJ HOSP,DEPT SURG,BANGKOK 10700,THAILAND. PHRAMONGKUTKLAO ROYAL THAI ARMY HOSP,DEPT SURG,BANGKOK,THAILAND. POLICE HOSP,DEPT SURG,BANGKOK,THAILAND. SIRIAJ HOSP,DEPT MED,CLIN EPIDEMIOL UNIT,BANGKOK,THAILAND. NR 23 TC 13 Z9 13 U1 0 U2 1 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0007-1323 J9 BRIT J SURG JI Br. J. Surg. PD JUL PY 1996 VL 83 IS 7 BP 982 EP 985 DI 10.1002/bjs.1800830731 PG 4 WC Surgery SC Surgery GA UW203 UT WOS:A1996UW20300027 PM 8813793 ER PT J AU Avery, RA Harris, JE Davis, CJ Borgaonkar, DS Byrd, JC Weiss, RB AF Avery, RA Harris, JE Davis, CJ Borgaonkar, DS Byrd, JC Weiss, RB TI Renal medullary carcinoma - Clinical and therapeutic aspects of a newly described tumor SO CANCER LA English DT Article DE renal medullary carcinoma; kidney neoplasms; sickle cell trait; cytogenetics; chemotherapy ID CELL CARCINOMA; TRANSLOCATION; CHEMOTHERAPY AB BACKGROUND. Renal medullary carcinoma is a newly described, aggressive kidney tumor. All patients with the disease have been African-American with sickle cell (SC) trait or hemoglobin SC disease. METHODS. Patient information was obtained from individual patient records and from the Department of Defense national data bank, The Defense Enrollment and Eligibility Reporting System. Data were obtained from either personal review of the patient's records or from discussion with the patient's physician. Cytogenetic studies were performed on one patient. RESULTS. Six patients are presented. All had SC trait. Median age was 24.5 years, and 1 patient was female. Time from diagnosis to death averaged 3 months (range: 1-7 mos). No objective responses were reported to a wide variety of chemo and immunotherapies: cyclophosphamide, doxorubicin, cisplatin; methotrexate, vinblastine, doxorubicin, and cisplatin; single agent interferon; single agent paclitaxel; or single agent vinblastine. Investigational regimens included topotecan, doxorubicin, and filgrastim; alpha-interferon, interleukin-2, and 5-fluorouracil; and single agent paclitaxel. Cytogenetic studies revealed numerous structural, as well as numerical anomalies. Of the cells successfully karyotlped (n = 4), 2 contained abnormalities of chromosome 3 and all contained monosomy 11. CONCLUSIONS. Renal medullary carcinoma is an aggressive, chemoresistant tumor. Time from discovery of tumor to patient death is very short and has not been altered by a wide variety of chemotherapies and immunotherapies. An unidentified genetic component is likely present. (C) 1996 American Cancer Society. C1 RUSH PRESBYTERIAN ST LUKES MED CTR,CHICAGO,IL 60612. ARMED FORCES INST PATHOL,GENITOURINARY BRANCH,WASHINGTON,DC 20306. MED CTR DELAWARE,NEWARK,DE. WALTER REED ARMY MED CTR,DIV HEMATOL ONCOL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP Avery, RA (reprint author), DWIGHT D EISENHOWER ARMY MED CTR,HEMATOL ONCOL SERV,FT GORDON,GA 30905, USA. NR 13 TC 73 Z9 74 U1 1 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD JUL 1 PY 1996 VL 78 IS 1 BP 128 EP 132 DI 10.1002/(SICI)1097-0142(19960701)78:1<128::AID-CNCR18>3.0.CO;2-1 PG 5 WC Oncology SC Oncology GA UR448 UT WOS:A1996UR44800018 PM 8646708 ER PT J AU Thompson, IM AF Thompson, IM TI Survival after radical retropubic prostatectomy of men with clinically localized high grade carcinoma of the prostate SO CANCER LA English DT Letter RP Thompson, IM (reprint author), USA,MED CORPS,BROOKE ARMY MED CTR,DEPT SURG,SAN ANTONIO,TX, USA. NR 2 TC 2 Z9 2 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD JUL 1 PY 1996 VL 78 IS 1 BP 181 EP 181 DI 10.1002/(SICI)1097-0142(19960701)78:1<181::AID-CNCR28>3.0.CO;2-V PG 1 WC Oncology SC Oncology GA UR448 UT WOS:A1996UR44800029 PM 8646718 ER PT J AU Lanza, E Schatzkin, A BallardBarbash, R Corle, D Clifford, C Paskett, E Hayes, D Bote, E Caan, B Shike, M Weissfeld, J Slattery, M Mateski, D Daston, C AF Lanza, E Schatzkin, A BallardBarbash, R Corle, D Clifford, C Paskett, E Hayes, D Bote, E Caan, B Shike, M Weissfeld, J Slattery, M Mateski, D Daston, C TI The polyp prevention trial II: Dietary intervention program and participant baseline dietary characteristics (vol 5, pg 385, 1996) SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Correction, Addition C1 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,WINSTON SALEM,NC. SUNY BUFFALO,SCH MED & BIOMED SCI,BUFFALO,NY. US DEPT VET AFFAIRS,VET AFFAIRS EDWARD HINES JR HOSP,HINES,IL 60141. KAISER FDN RES INST,OAKLAND,CA. MEM SLOAN KETTERING CANC CTR,NEW YORK,NY 10021. UNIV PITTSBURGH,PITTSBURGH,PA. UNIV UTAH,SALT LAKE CITY,UT. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. WESTAT CORP,ROCKVILLE,MD. RP Lanza, E (reprint author), NCI,BETHESDA,MD 20892, USA. NR 1 TC 4 Z9 4 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 1055-9965 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD JUL PY 1996 VL 5 IS 7 BP 584 EP 584 PG 1 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA UW619 UT WOS:A1996UW61900015 ER PT J AU Ebersole, D ComposEsteve, M Miller, L AF Ebersole, D ComposEsteve, M Miller, L TI Hugging perfusion balloon salvage of a right coronary artery angioplasty SO CATHETERIZATION AND CARDIOVASCULAR DIAGNOSIS LA English DT Article DE coronary angioplasty; large coronary arteries; hugging balloon ID ATHERECTOMY; CATHETER; PTCA AB A case is described in which hugging balloons, one a perfusion and the other a non-perfusion balloon, were used to salvage a failed coronary angioplasty. A discussion concerning balloon combinations, techniques, and therapeutic options is included. (C) 1996 Wiley-Liss, Inc. RP Ebersole, D (reprint author), BROOKE ARMY MED CTR, SERV CARDIOL, MCHE, MDC, FT SAM HOUSTON, TX 78234 USA. NR 11 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0098-6569 J9 CATHETER CARDIO DIAG JI Catheter. Cardiovasc. Diagn. PD JUL PY 1996 VL 38 IS 3 BP 308 EP 311 PG 4 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA UU434 UT WOS:A1996UU43400021 ER PT J AU Smee, DF Sidwell, RW Huffman, JH Huggins, JW Kende, M Verbiscar, AJ AF Smee, DF Sidwell, RW Huffman, JH Huggins, JW Kende, M Verbiscar, AJ TI Antiviral activities of tragacanthin polysaccharides an Punta Toro virus infections in mice SO CHEMOTHERAPY LA English DT Article DE antiviral; astragalus; tragacanthin; polysaccharide; bunyavirus; phlebovirus ID DISEASE AB Tragacanthin polysaccharides from Astragalus brachycentrus (AV208) and Astragalus echidnaeformis (AV212) plants, which are devoid of in vitro antiviral activity, were evaluated in a mouse model of Punta Toro virus (PTV) infection. The PTV (a phlebovirus member of the Bunyaviridae family of viruses) is a model for studying the treatment of Rift Valley fever and hantavirus infections. Single intraperitoneal treatments with 12.5-200 mg/kg/day doses of AV212 given 24 h before or 4 and 24 h after virus inoculation protected the majority of mice from mortality. Single treatments with AV208 were ineffective when given 24 h before the virus challenge; however, protection was afforded when treatments were administered at 4 and 24 h following virus inoculation. In a follow-up study, AV208 treatments of 1.6-50 mg/kg/day given 24 h subsequent to virus exposure caused reductions in mortality, liver infection scores, liver and spleen virus titers, and serum transaminases, The polysaccharides did not activate lymphocytes or natural killer cells, nor was interferon induced in treated mice. However, mice pretreated with fumed silica (a macrophage poison) and infected with the PTV were not protected by subsequent administration of AV208 or AV212 at 50 mg/kg, providing evidence that activation of peritoneal macrophages by the polysaccharides affords protection to infected animals. These compounds should be considered for the potential treatment of significant human infections induced by bunyaviruses and hantaviruses. C1 USA,MED RES INST INFECT DIS,DIV VIROL,FT DETRICK,MD 21702. ANVER BIOSCI DESIGN INC,SIERRA MADRE,CA. RP Smee, DF (reprint author), UTAH STATE UNIV,DEPT ANIM DAIRY & VET SCI,INST ANTIVIRAL RES,LOGAN,UT 84322, USA. FU NCI NIH HHS [1R43 CA38256] NR 26 TC 10 Z9 11 U1 0 U2 2 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0009-3157 J9 CHEMOTHERAPY JI Chemotherapy PD JUL-AUG PY 1996 VL 42 IS 4 BP 286 EP 293 PG 8 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA UT811 UT WOS:A1996UT81100009 PM 8804797 ER PT J AU Chatterton, RT Vogelsong, KM Lu, YC Ellman, AB Hudgens, GA AF Chatterton, RT Vogelsong, KM Lu, YC Ellman, AB Hudgens, GA TI Salivary alpha-amylase as a measure of endogenous adrenergic activity SO CLINICAL PHYSIOLOGY LA English DT Article DE stress; exercise; examinations; heat; cold; salivary amylase; plasma norepinephrine; plasma epinephrine ID PAROTID-GLAND; SECRETION; CATECHOLAMINES; RESPONSES; EXERCISE; SAUNA AB This investigation was designed to evaluate the production rates and concentrations of salivary alpha-amylase as a measure of adrenergic activity under several conditions of stress in human subjects, Saliva and blood samples were simultaneously collected from men at four 15 min intervals both before and after regimens for exercise, a written examination, or a rest period, The regressions of salivary alpha-amylase on plasma norepinephrine (NE) concentrations were significant for both exercise (P<0.001) and examination (P<0.01) protocols, Aerobic exercise induced a 3-fold mean increase in alpha-amylase; both NE and epinephrine (EP) increased approximate to 5-fold over control levels. Levels of alpha-amylase and NE returned to control levels within 30-45 min after exercise, but EP remained elevated by approximate to 2-fold during the remaining hour of observation, During the written examination, alpha-amylase and NE, but not EP, concentrations increased in parallel. In further studies the effects of exercise and exposure to heat and cold on the relationship of salivary alpha-amylase to heart rate and body temperature were investigated. Greater intensities of exercise were associated with greater increases in alpha-amylase concentrations. During heat exposure in a sauna (66 degrees C for 40 min) amylase, heart rate and body temperature all increased progressively. However, during exposure to cold (4 degrees C for 40 min) amylase increased rapidly, though heart rate and body temperature remained unchanged. Salivary cortisol concentrations were unchanged during exposure to heat or cold. We conclude that salivary alpha-amylase concentrations are predictive of plasma catecholamine levels, particularly NE, under a variety of stressful conditions, and may be a more direct and simple end point of catecholamine activity than are changes in heart rate. C1 USA,RES LAB,ABERDEEN PROVING GROUND,MD. RP Chatterton, RT (reprint author), NORTHWESTERN UNIV,SCH MED,DEPT OBSTET & GYNECOL,333 E SUPERIOR ST,CHICAGO,IL 60611, USA. NR 23 TC 295 Z9 303 U1 6 U2 80 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0144-5979 J9 CLIN PHYSIOL JI Clin. Physiol. PD JUL PY 1996 VL 16 IS 4 BP 433 EP 448 DI 10.1111/j.1475-097X.1996.tb00731.x PG 16 WC Physiology SC Physiology GA UY143 UT WOS:A1996UY14300010 PM 8842578 ER PT J AU English, JC McCollough, ML Grabski, WJ AF English, JC McCollough, ML Grabski, WJ TI A pigmented scalp nodule: Malignant blue nevus SO CUTIS LA English DT Article AB The malignant blue nevus is an aggressive dermal melanocytic neoplasm. The lesion occurs most frequently on the scalp of men in their fifth decade of life, often metastasizes to the regional lymph nodes, and commonly results in fatality. Controversy exists as to whether this lesion is a malignant melanoma in the dermis or a separate neoplasm arising in the architecture of a cellular blue nevus. The lesion is treated with wide local excision and close monitoring for the occurrence of metastatic disease. C1 USAR,FT SAM HOUSTON,TX. USA,FT SAM HOUSTON,TX. NR 6 TC 13 Z9 13 U1 0 U2 1 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0011-4162 J9 CUTIS JI Cutis PD JUL PY 1996 VL 58 IS 1 BP 40 EP 42 PG 3 WC Dermatology SC Dermatology GA UX208 UT WOS:A1996UX20800006 PM 8823547 ER PT J AU Smoak, BL McClain, JB Brundage, JF Broadhurst, L Kelly, DJ Dasch, GA Miller, RN AF Smoak, BL McClain, JB Brundage, JF Broadhurst, L Kelly, DJ Dasch, GA Miller, RN TI An outbreak of spotted fever rickettsiosis in US army troops deployed to Botswana SO EMERGING INFECTIOUS DISEASES LA English DT Article ID PREVALENCE; ZIMBABWE C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. USA,MEDDAC,VICENZA,ITALY. USN,RES INST,VIRAL & RICKETTSIAL DIS PROGRAM,BETHESDA,MD. RP Smoak, BL (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV PREVENT MED,WASHINGTON,DC 20307, USA. NR 11 TC 41 Z9 41 U1 0 U2 0 PU CENTER DISEASE CONTROL PI ATLANTA PA ATLANTA, GA 30333 SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JUL-SEP PY 1996 VL 2 IS 3 BP 217 EP 221 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA VA263 UT WOS:A1996VA26300009 PM 8903233 ER PT J AU Cardello, AV Schutz, HG AF Cardello, AV Schutz, HG TI Food appropriateness measures as an adjunct to consumer preference/acceptability evaluation SO FOOD QUALITY AND PREFERENCE LA English DT Article; Proceedings Paper CT 2nd Pangborn Sensory Science Symposium CY JUL 30-AUG 03, 1995 CL UNIV CALIF DAVIS, DAVIS, CA HO UNIV CALIF DAVIS AB Twenty-nine laboratory taste tests were conducted each with from 27 to 38 consumers. During each test, one or more food products were tested for preference/acceptability and then rated for their appropriateness in 10 different use situations. Additional tests were conducted to assess any biasing effect of collecting the appropriateness data on the obtained acceptance ratings and the applicability of appropriateness scaling to conceptual products. Results indicated that: (I) appropriateness ratings had very similar patterns for products that varied little in basic physical properties that might influence use; (2) there were significant differences among products in their appropriateness ratings for certain use situations, enabling useful distinction of the products; (3) products that did not differ in preference/acceptability had significant differences in their appropriateness for certain food use situations; (4) the testing procedure was equally effective for use with actual and conceptual products; and (5) there was no evidence of a preference-appropriateness interaction effect. It is concluded that appropriateness ratings can be obtained in taste tests without jeopardizing the validity of preference/acceptability judgments. In addition, appropriateness judgments obtained as part of routine sensory evaluation can provide valuable information to guide product development and to maximize product utility in the intended use situation. Copyright (C) 1996 Elsevier Science Ltd C1 UNIV CALIF DAVIS,DEPT FOOD SCI & TECHNOL,DAVIS,CA 95616. RP Cardello, AV (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 17 TC 49 Z9 50 U1 2 U2 11 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0950-3293 J9 FOOD QUAL PREFER JI Food. Qual. Prefer. PD JUL-OCT PY 1996 VL 7 IS 3-4 BP 239 EP 249 DI 10.1016/S0950-3293(96)00012-2 PG 11 WC Food Science & Technology SC Food Science & Technology GA VQ364 UT WOS:A1996VQ36400012 ER PT J AU Salomon, M Scrosati, B AF Salomon, M Scrosati, B TI Lithium batteries: Present trends and prospects SO GAZZETTA CHIMICA ITALIANA LA English DT Article ID MACROCYCLIC LIGAND COMPLEXES; POLYMER ELECTROLYTES; PROPYLENE CARBONATE; IONIC-CONDUCTIVITY; CELL; GRAPHITE; INTERCALATION; ACETONITRILE; CATHODE; SYSTEM AB The present review discusses the major objectives for the development of high-energy density rechargeable lithium batteries for both commercial and military uses. The various options available for several types of lithium batteries, and the specific problems associated with each of the battery components (anode, cathode, and electrolyte) are discussed, and recent advances in practical development and in basic research are reviewed. C1 UNIV ROMA LA SAPIENZA,I-00185 ROME,ITALY. RP Salomon, M (reprint author), USA,PSD ARL,CHEM BIOL SCI DIV,FT MONMOUTH,NJ 07703, USA. NR 82 TC 20 Z9 20 U1 0 U2 0 PU SOC CHIMICA ITALIANA PI ROME PA VIALE LIEGI 48, I-00198 ROME, ITALY SN 0016-5603 J9 GAZZ CHIM ITAL JI Gazz. Chim. Ital. PD JUL PY 1996 VL 126 IS 7 BP 415 EP 427 PG 13 WC Chemistry, Multidisciplinary SC Chemistry GA VB551 UT WOS:A1996VB55100002 ER PT J AU Jaros, DL AF Jaros, DL TI Overview of corps of engineers waste containment activities involving geosynthetics SO GEOTEXTILES AND GEOMEMBRANES LA English DT Article; Proceedings Paper CT 9th GRI Conference on Geosynthetics in Infrastructure Enhancement and Remediation CY DEC 12-13, 1995 CL DREXEL UNIV, GEOSYNTHET RES INST, PHILADELPHIA, PA SP Geosynthet Res Inst, Natl Sci Fdn, Geomech Geotech & Geo Environm Syst Program HO DREXEL UNIV, GEOSYNTHET RES INST AB Containment has proven to be a viable option for remediating many hazardous waste sites. The US Army Corps of Engineers (COE) has been involved in the design and/or construction of more than 40 landfill remediation projects for Superfund projects and military installations since 1982. Geosynthetics have played a major role in the success of these projects. This paper focuses on COE involvement in various environmental restoration programs which use geosynthetics and the activities being conducted to further advance the state-of-the-practice in geosynthetic engineering. Geosynthetic guidance development and training by the COE are discussed along with examples of geosynthetic containment applications. In addition, geosynthetic design and construction issues related to geomembrane seam testing, interface friction testing, test sections, quality assurance/quality, control (QA/QC) and monitoring are discussed. Published by Elsevier Science Ltd. RP Jaros, DL (reprint author), USA,CORPS ENGINEERS,1255 W CTR RD,OMAHA,NE 68144, USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0266-1144 J9 GEOTEXT GEOMEMBRANES JI Geotext. Geomembr. PD JUL-AUG PY 1996 VL 14 IS 7-8 BP 331 EP 339 DI 10.1016/0266-1144(96)89791-3 PG 9 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA VE800 UT WOS:A1996VE80000002 ER PT J AU Georges, JB Lux, RA Yeung, SP Lau, KY Chang, W AF Georges, JB Lux, RA Yeung, SP Lau, KY Chang, W TI Simultaneous fiber-optic transport and RF phase control of narrow-band millimeter-wave signals using multicontact monolithic semiconductor lasers SO IEEE PHOTONICS TECHNOLOGY LETTERS LA English DT Article AB We demonstrate fiber-optic transport over 2.2 km of single-mode fiber with continuous RF phase control of narrow-band millimeter-wave signals using a three-section monolithic distributed Bragg reflector (DBR) laser, By injection-locking the laser at the cavity round-trip resonant frequency of 45 GHz, we achieve 360 degrees of continuous, linear RF phase control of the input mm-wave signal by simply varying the bias current into the laser. The RF phase shift of the 45 GHz tone versus bias current into the phase section of the laser is characterized in detail, Carrier-to-noise and locking bandwidth measurements are performed, Dynamic RF phase control of the mm-wave optical transmitter is also demonstrated by modulating the bias current into the phase section of the device, resulting in an RF phase modulated 45 GHz subcarrier with good AM suppression. C1 USA,RES LAB,AMSL,EP,EF,FT MONMOUTH,NJ 07703. UNIV CALIF BERKELEY,EECS DEPT,BERKELEY,CA 94720. RP Georges, JB (reprint author), LGC TECHNOL,2855 TELEGRAPH AVE,SUITE 302,BERKELEY,CA 94705, USA. NR 5 TC 12 Z9 12 U1 1 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 1041-1135 J9 IEEE PHOTONIC TECH L JI IEEE Photonics Technol. Lett. PD JUL PY 1996 VL 8 IS 7 BP 953 EP 955 DI 10.1109/68.502282 PG 3 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA UT300 UT WOS:A1996UT30000036 ER PT J AU Hill, SC Chylek, P AF Hill, SC Chylek, P TI A rigorous explanation for the resonances observed in the scattering from spherical ice particles - Comment SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Editorial Material ID MORPHOLOGY-DEPENDENT RESONANCES; STIMULATED RAMAN-SCATTERING; TIME-INDEPENDENT PERTURBATION; WHISPERING-GALLERY MODES; MICROMETER-SIZE DROPLETS; SUM-FREQUENCY GENERATION; PARTIAL-WAVE RESONANCES; DIELECTRIC SPHERES; LIGHT-SCATTERING; MIE SCATTERING C1 DALHOUSIE UNIV,DEPT PHYS,HALIFAX,NS B3H 3J5,CANADA. RP Hill, SC (reprint author), USA,RES LAB,ADELPHI,MD 20783, USA. NR 74 TC 0 Z9 0 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD JUL PY 1996 VL 44 IS 7 BP 1052 EP 1055 DI 10.1109/8.504315 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA UU610 UT WOS:A1996UU61000021 ER PT J AU Rauscher, C Pond, JM Tait, GB AF Rauscher, C Pond, JM Tait, GB TI Cryogenic microwave channelized receiver SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article AB The channelized receiver being presented demonstrates the use of high temperature superconductor technology in a microwave system setting where superconductor, microwave-monolithic-intergraed-circuit, and hybrid-integrated-circuit components are united in one package and cooled to liquid-nitrogen temperatures, The receiver consists of a superconducting X-band four-channel demultiplexer with 100-MHz-wide channels, four commercial monolithically integrated mixers, and four custom-designed hybrid-circuit. detectors containing heterostructure ramp diodes, The composite receiver unit has been integrated into the payload of the second-phase NRL high temperature superconductor space experiment (HTSSE-II). Prior to payload assembly, the response characteristics of the receiver were measured as functions of frequency, temperature, and drive levels. The article describes the circuitry, discusses the kev issues related to design and implementation, and summarizes the experimental result. C1 US MIL ACAD,DEPT ELECT ENGN & COMP SCI,W POINT,NY 10996. RP Rauscher, C (reprint author), USN,RES LAB,DIV ELECTR SCI & TECHNOL,WASHINGTON,DC 20375, USA. NR 5 TC 7 Z9 7 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD JUL PY 1996 VL 44 IS 7 BP 1240 EP 1247 DI 10.1109/22.508229 PG 8 WC Engineering, Electrical & Electronic SC Engineering GA UX545 UT WOS:A1996UX54500005 ER PT J AU Mahle, JJ Friday, DK LeVan, MD AF Mahle, JJ Friday, DK LeVan, MD TI Pressure swing adsorption for air purification .1. Temperature cycling and role of weakly adsorbed carrier gas SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID BULK SEPARATION; DIFFUSION; MIXTURES; SIMULATION; MODEL AB Nonisothermal effects are known to he generally important in gas-phase adsorption processes. This paper considers the role of a weakly adsorbed carrier gas in pressure swing adsorption for purification. A combination of experimental and mathematical modeling results is presented in order to understand and describe the influence of the carrier gas on the behavior of the bed. Dry air is fed to beds of BPL activated carbon. Variations consider a feed of pure helium and a packing of glass beads or an empty column. The role of the heat capacity of the end regions of the bed is emphasized. For air with activated carbon, which adsorbs weakly with insignificant separation of nitrogen and oxygen, periodic state behavior leads to subcooling of the feed-inlet end of the bed and, for cycles of moderately short duration, to temperature rectification, or the establishment of a permanent oscillating temperature wave in the bed. The effect of the volumetric purge-to-feed ratio on the extent of this region and degree of subcooling is examined. C1 GUILD ASSOCIATES INC,BALTIMORE,MD 21236. UNIV VIRGINIA,DEPT CHEM ENGN,CHARLOTTESVILLE,VA 22903. RP Mahle, JJ (reprint author), USA,EDGEWOOD RES,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 23 TC 20 Z9 20 U1 2 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0888-5885 J9 IND ENG CHEM RES JI Ind. Eng. Chem. Res. PD JUL PY 1996 VL 35 IS 7 BP 2342 EP 2354 DI 10.1021/ie950475c PG 13 WC Engineering, Chemical SC Engineering GA UW700 UT WOS:A1996UW70000030 ER PT J AU LeDuc, CA Campbell, JM Rossin, JA AF LeDuc, CA Campbell, JM Rossin, JA TI Effect of lanthana as a stabilizing agent in titanium dioxide support SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID THERMAL-STABILITY; PHASE-TRANSFORMATION; TEXTURAL EVOLUTION; MEMBRANES; ALUMINA; CATALYSTS AB The thermal stability of between 1 and 5 wt % lanthana-doped TiO2 was investigated. Three methods of aging the titania support were studied: stagnant air heating for 12 h at temperatures ranging from 450 to 900 degrees C, flowing humid 450 degrees C air for up to 25 days, and flowing humid 650 degrees C air for up to 30 days. The thermal stability was assessed using BET surface area and XRD. Chlorodifluoromethane (HCFC22) oxidation was used as a probe reaction to determine the effects of thermal aging on the reactivity of the catalyst. The XRD results indicate that the decrease in surface area corresponds to the phase transformation from anatase to rutile. In the fixed time results, all doping levels achieved the same elevated stability, increasing the phase transition temperature from approximately 450 to about 650 degrees C. However, when the support was aged by exposure for an extended time, increasing the lanthana loading increased the thermal stability. This surface area thermal stability was shown to be related to the activity of the catalyst in oxidizing HCFC22. C1 GUILD ASSOCIATES,BALTIMORE,MD 21236. RP LeDuc, CA (reprint author), USA,ERDC,SCBRD,RTE,BLDG E3220,ABERDEEN PROVING GROUND,MD 21010, USA. NR 14 TC 42 Z9 43 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0888-5885 J9 IND ENG CHEM RES JI Ind. Eng. Chem. Res. PD JUL PY 1996 VL 35 IS 7 BP 2473 EP 2476 DI 10.1021/ie960112s PG 4 WC Engineering, Chemical SC Engineering GA UW700 UT WOS:A1996UW70000048 ER PT J AU Cheville, NF Olsen, SC Jensen, AE Stevens, MG Florance, AM Houng, HSH Drazek, ES Warren, RL Hadfield, TL Hoover, DL AF Cheville, NF Olsen, SC Jensen, AE Stevens, MG Florance, AM Houng, HSH Drazek, ES Warren, RL Hadfield, TL Hoover, DL TI Bacterial persistence and immunity in goats vaccinated with a purE deletion mutant or the parental 16M strain of Brucella melitensis SO INFECTION AND IMMUNITY LA English DT Article ID SALMONELLA-TYPHIMURIUM; SHIGELLA-FLEXNERI; ABORTUS INFECTION; MICE; PROTECTION; RESPONSES AB To evaluate host responses, young goats were inoculated subcutaneously with a genetic deletion mutant (Delta purE201) of Brucella melitensis (n = 6), its virulent parental strain 16M (n = 6), or saline (n = 6). No clinical evidence of brucellosis was seen in any goat. Serum antibody titers peaked at postinoculation day (PID) 14. Bacteria in lymph nodes that drained sites of vaccination reached peak numbers of >10(6) CFU/g in both infected groups at PID 7 and progressively declined to PID 84. At necropsy, bacteria were present in mammary lymph nodes or spleen of 33% of goats given virulent 16M but in none of goats given the purE mutant. Lymphadenitis, most severe in goats given 16M, involved depletion of lymphocytes and germinal centers, proliferation of lymphoblasts, and vasculitis. By PID 28, lymph node architecture was restored; there was marked germinal center formation and medullary plasmacytosis. Brucellar antigens, detected with immunoperoxidase techniques, were prominent in capsular granulomas but not in lymph node cortices. Ultrastructurally, bacteria were found in macrophages (>97%) and small Lymphocytes (<3%); but not in large lymphocytes. Bacteria were intact in small lymphocytes but in macrophages were in various stages of degradation. The Delta purE phenotype of Delta purE201 was preserved during infection of goat lymph nodes. Unlike Salmonella spp. purE mutants, strain Delta purE201 may be a candidate for efficacy testing; it produced immune responses, was cleared from visceral tissues, and produced less severe pathologic changes than its wild-type parent. C1 USDA,NATL ANIM DIS CTR,AMES,IA 50010. WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,DEPT INFECT & PARASIT DIS,WASHINGTON,DC 20306. RP Cheville, NF (reprint author), IOWA STATE UNIV SCI & TECHNOL,DEPT VET PATHOL,AMES,IA 50011, USA. NR 32 TC 24 Z9 25 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUL PY 1996 VL 64 IS 7 BP 2431 EP 2439 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA UT657 UT WOS:A1996UT65700010 PM 8698463 ER PT J AU Lindler, LE Hadfield, TL Tall, BD Snellings, NJ Rubin, FA VandeVerg, LL Hoover, D Warren, RL AF Lindler, LE Hadfield, TL Tall, BD Snellings, NJ Rubin, FA VandeVerg, LL Hoover, D Warren, RL TI Cloning of a Brucella melitensis group 3 antigen gene encoding Omp28, a protein recognized by the humoral immune response during human brucellosis SO INFECTION AND IMMUNITY LA English DT Article ID OUTER-MEMBRANE PROTEINS; MONOCLONAL-ANTIBODIES; ABORTUS INFECTION; ENVELOPE PROTEIN; O-POLYSACCHARIDE; MICE; STRAINS; CELL; PROTECTION; IDENTIFICATION AB Brucella group 3 antigens (Ags) are outer membrane proteins (OMPs) with a molecular mass ranging from 25 to 30 kDa. The OMPs are of interest partially because of their potential use as vaccine and diagnostic reagents. We used human convalescent antibody (Ab) to clone a gene that encoded a 28-kDa protein from a lambda gt11 library of Brucella melitensis 16M genomic DNA. DNA sequence analysis revealed a single open reading frame that would encode a protein of 26,552 Da. The 28-kDa protein had a primary amino acid sequence that was 43% similar to a previously described Brucella abortus group 3 Ag, Omp25 (P. de Wergifosse, P. Lintermans, J. N. Limet, and A. Cloeckaert, J. Bacteriol. 177:1911-1914, 1995). The similarity to a known group 3 OMP, immunoreactivity with Ab prepared against B. abortus group Ags, immunolabeling of whole cells, and Southern hybridization led to our conclusion that the B. melitensis 28-kDa protein was a group 3 protein distinct from B. abortus Omp25. We designated the B. melitensis protein Omp28. Human convalescent sera from patients infected with B. abortus and Brucella suis as well as rabbit antisera prepared against killed B. abortus whole cells recognized B. melitensis Omp28 on Western blots (immunoblots). Furthermore, mice and goats infected with smooth strains of B. melitensis produced Abs against Omp28. Our results may begin to explain the variability in molecular weight seen in Brucella group Ags and point toward their possible use in vaccination against infection as well as diagnosis of the disease. C1 ARMED FORCES INST PATHOL,DEPT INFECT & PARASIT DIS,WASHINGTON,DC 20306. US FDA,CTR FOOD SAFETY & APPL NUTR,WASHINGTON,DC 20204. RP Lindler, LE (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307, USA. OI Tall, Ben/0000-0003-0399-3629 NR 45 TC 45 Z9 52 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUL PY 1996 VL 64 IS 7 BP 2490 EP 2499 PG 10 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA UT657 UT WOS:A1996UT65700018 PM 8698471 ER PT J AU Legree, PJ Pifer, ME Grafton, FC AF Legree, PJ Pifer, ME Grafton, FC TI Correlations among cognitive abilities are lower for higher ability groups SO INTELLIGENCE LA English DT Article AB Previous research demonstrates that correlations among IQ tests are lower when estimated using higher ability groups (Detterman & Daniel, 1989; Lynn, 1990). However, this phenomenon has only been documented using individually administered measures of intelligence and attempts to extend the demonstration to other specialized abilities have failed (Detterman. 1993). This study divides the 1980 Armed Services Vocational Aptitude Battery (ASVAB) weighted norming sample into five ability levels with similar levels of variance. Analyses show that ASVAB tests are less correlated within higher ability groups provided that the scales used to define the groups are psychometrically sound: For three highly skewed ASVAB tests, a ceiling effect prevents this phenomenon; for the remaining seven tests, the phenomenon replicates; and the magnitude of the effect is proportional to the skewness of the scale, r = -.85. These findings support the assertion that cognitive abilities are less correlated in higher ability groups, imply that greater classification effects can be associated with more intelligent groups, and qualify the use of the multivariate correction for restriction of range. RP Legree, PJ (reprint author), USA,RES INST,OPRRU,5001 EISENHOWER AVE,ALEXANDRIA,VA 22333, USA. NR 19 TC 47 Z9 47 U1 0 U2 0 PU ABLEX PUBL CORP PI NORWOOD PA 355 CHESTNUT ST, NORWOOD, NJ 07648 SN 0160-2896 J9 INTELLIGENCE JI Intelligence PD JUL-AUG PY 1996 VL 23 IS 1 BP 45 EP 57 DI 10.1016/S0160-2896(96)80005-5 PG 13 WC Psychology, Multidisciplinary SC Psychology GA VR342 UT WOS:A1996VR34200004 ER PT J AU Mitasova, H Hofierka, J Zlocha, M Iverson, LR AF Mitasova, H Hofierka, J Zlocha, M Iverson, LR TI Modelling topographic potential for erosion and deposition using GIS SO INTERNATIONAL JOURNAL OF GEOGRAPHICAL INFORMATION SYSTEMS LA English DT Article ID SOIL LOSS EQUATION; DIGITAL ELEVATION MODELS; LAND CLASSIFICATION; REGULARIZED SPLINE; DRAINAGE NETWORKS; INTERPOLATION; SYSTEM; CESIUM-137; LANDSCAPE; TENSION AB Modelling of erosion and deposition in complex terrain within a geographical information system (GIS) requires a high resolution digital elevation model (DEM), reliable estimation of topographic parameters, and formulation of erosion models adequate for digital representation of spatially distributed parameters. Regularized spline with tension was integrated within a GIS for computation of DEMs and topographic parameters from digitized contours or other point elevation data. For construction of flow lines and computation of upslope contributing areas an algorithm based on vector-grid approach was developed. The spatial distribution of areas with topographic potential for erosion or deposition was then modelled using the approach based on the unit stream power and directional derivatives of surface representing the sediment transport capacity. The methods presented are illustrated on study areas in central Illinois and the Yakima Ridge, Washington. C1 UNIV ILLINOIS, DEPT GEOG, URBANA, IL 61801 USA. COMENIUS UNIV BRATISLAVA, FAC NAT SCI, BRATISLAVA 84215, SLOVAKIA. ILLINOIS NAT HIST SURVEY, CHAMPAIGN, IL 61820 USA. RP Mitasova, H (reprint author), USA, CONSTRUCT ENGN RES LABS, POB 9005, CHAMPAIGN, IL 61826 USA. RI Namikawa, Laercio/C-5559-2013; Iverson, Louis/C-7554-2009; Hofierka, Jaroslav/P-4207-2016; OI Namikawa, Laercio/0000-0001-7847-1804; Iverson, Louis/0000-0001-9501-471X; Hofierka, Jaroslav/0000-0002-7691-8518; Mitasova, Helena/0000-0002-6906-3398 NR 38 TC 217 Z9 227 U1 5 U2 52 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0269-3798 J9 INT J GEOGR INF SYST JI Int. J. Geogr. Inf. Syst. PD JUL-AUG PY 1996 VL 10 IS 5 BP 629 EP 641 DI 10.1080/02693799608902101 PG 13 WC Geography; Information Science & Library Science SC Geography; Information Science & Library Science GA UT383 UT WOS:A1996UT38300008 ER PT J AU Forrestal, MJ Frew, DJ Hanchak, SJ Brar, NS AF Forrestal, MJ Frew, DJ Hanchak, SJ Brar, NS TI Penetration of grout and concrete targets with ogive-nose steel projectiles SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE penetration; concrete targets; ogive-nose steel; nose erosion; striking velocities; compressive strength AB We conducted depth of penetration experiments into grout and concrete targets with ogive-nose steel projectiles. Powder guns launched 0.064 kg, 12.9 mm diameter projectiles into grout targets with unconfined compressive strengths of 13.5 MPa (2.0 ksi) and 21.6 MPa (3.1 ksi). For the concrete targets, powder guns launched projectiles with length-to-diameter ratios of 10; a 0.48 kg, 20.3 mm diameter rod, and a 1.60 kg, 30.5 mm diameter rod. Concrete targets had unconfined compressive strength of 62.8 MPa (9.1 ksi)for the 0.48 kg rods and unconfined compressive strength of 51.0 MPa (7.4 ksi)for the 1.60 kg rods. For these experiments, penetration depth increased as striking velocity increased until nose erosion became excessive. Thus, we determined experimentally the striking velocities corresponding to maximum penetration depths. Predictions from a previously published model are in good agreement with data until nose erosion becomes excessive. Copyright (C) 1996 Elsevier Science Ltd. C1 USA,WATERWAYS EXPT STN,VICKSBURG,MS 39180. UNIV DAYTON,RES INST,DAYTON,OH 45469. RP Forrestal, MJ (reprint author), SANDIA NATL LABS,POB 5800,ALBUQUERQUE,NM 87185, USA. NR 5 TC 142 Z9 239 U1 3 U2 25 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD JUL PY 1996 VL 18 IS 5 BP 465 EP 476 DI 10.1016/0734-743X(95)00048-F PG 12 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA UK317 UT WOS:A1996UK31700001 ER PT J AU Rice, VJB Sharp, MA Tharion, WJ Williamson, TL AF Rice, VJB Sharp, MA Tharion, WJ Williamson, TL TI The effects of gender, team size, and a shoulder harness on a stretcher-carry task and post-carry performance .1. A stimulated carry from a remote site SO INTERNATIONAL JOURNAL OF INDUSTRIAL ERGONOMICS LA English DT Article DE stretcher carrying; physical workload; patient evacuation; performance; team carrying ID SOLDIER PERFORMANCE AB This study examined the effects of gender, two- vs. four-person teams, and use of a shoulder harness vs. a hand carry on the ability of participants to simulate the transport of patients during a prolonged stretcher carry, and to simulate the defense and medical treatment of patients following the stretcher carry. Participants carried a 6.8-kg stretcher containing an 81.6-kg manikin at a constant rate of 4.8 km/h for as long as possible, up to a half hour. Dependent measures included carry time, weapon firing, fine-motor coordination, heart rate, oxygen uptake, perceived exertion, and subjective symptoms, Analysis of variance and post-hoc Newman-Keuls comparison of means revealed that men carried stretchers longer than women (p < 0.05). Harness use resulted in the stretcher being carried longer (23.1 +/- 18.9 vs. 6.1 +/- 5.9 min), at lower heart rates (141.9 +/- 17.9 vs. 149.9 +/- 14.7 beats per min), at slightly higher intensity (46 +/- 8 vs. 42 +/- 7% VO2 max) (p < 0.05), and with less fatigue in the forearm and hand(p < 0.05). Four-person teams maintained pre-carry fine-motor and marksmanship scores and carried longer (16.9 +/- 11.0 vs. 12.3 +/- 11.4 min), while working at a slightly lower intensity (43 +/- 8 vs. 45 +/- 8% VO(2)max), compared with two-person teams (p < 0.05). Use of four-person teams with a harness resulted in an 8-fold increase in carry time, compared with two-person hand-carry teams (24.5 +/- 9.0 vs. 3.0 +/- 1.8 min). Four-person teams with a shoulder harness are therefore recommended for prolonged carries. C1 GEOCENTERS INC,NEWTON,MA 02159. RP Rice, VJB (reprint author), USA,ENVIRONM MED RES INST,OCCUPAT PHYSIOL DIV,NATICK,MA 01760, USA. NR 22 TC 14 Z9 15 U1 1 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-8141 J9 INT J IND ERGONOM JI Int. J. Ind. Ergon. PD JUL PY 1996 VL 18 IS 1 BP 27 EP 40 DI 10.1016/0169-8141(95)00026-7 PG 14 WC Engineering, Industrial; Ergonomics SC Engineering GA VD101 UT WOS:A1996VD10100003 ER PT J AU Rice, VJB Sharp, MA Tharion, WJ Williamson, TL AF Rice, VJB Sharp, MA Tharion, WJ Williamson, TL TI The effects of gender, team size, and a shoulder harness on a stretcher-carry task and post-carry performance .2. A mass-casualty simulation SO INTERNATIONAL JOURNAL OF INDUSTRIAL ERGONOMICS LA English DT Article DE stretcher carry; physical workload; patient evacuation; performance; team carry AB This study examined repeated, short-distance stretcher carries and the effects of gender, a shoulder harness, and team size on simulated transportation, defense, and medical treatment of patients, Participants carried a 6.8-kg stretcher, loaded with an 81.6-kg manikin, for a distance of 50 m, lifted it onto a simulated ambulance, and returned 50 m to retrieve the next patient. Participants completed as many cycles as possible in 15 min, Dependent measures included number of carries, weapon firing, fine-motor coordination, heart rate, perceived exertion, and physical symptoms. Analysis of variance and post-hoc Newman-Keuls comparison of means revealed that men completed more carries than women (18.0 +/- 1.6 vs. 14.5 +/- 2.0 carries, p < 0.001), and women reported more upper extremity discomfort (p < 0.05). Harness use resulted in slightly faster fine-motor performance (46.1 +/- 8.3 vs. 47.6 +/- 7.7 s; p = 0.03) and less discomfort in the upper extremities (p < 0.05) than hand carries. Four-person teams resulted in reduced discomfort in the neck and upper extremity(p < 0.05) and improved post-carry fine-motor coordination (47.6 +/- 8.3 vs. 46.0 +/- 7.7 s; p = 0.02), as well as increasing weapon firing accuracy for women (p < 0.05). Four-person hand-carry teams completed more carries than any other team-size X harness combination (p < 0.01). For mass-casualty scenarios, four-person teams are recommended. A harness system should be available for two-person and female teams. C1 GEOCENTERS INC,NEWTON,MA 02159. RP Rice, VJB (reprint author), USA,ENVIRONM MED RES INST,OCCUPAT PHYSIOL DIV,NATICK,MA 01760, USA. NR 14 TC 8 Z9 8 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-8141 J9 INT J IND ERGONOM JI Int. J. Ind. Ergon. PD JUL PY 1996 VL 18 IS 1 BP 41 EP 49 DI 10.1016/0169-8141(95)00027-5 PG 9 WC Engineering, Industrial; Ergonomics SC Engineering GA VD101 UT WOS:A1996VD10100004 ER PT J AU Muza, SR Levine, L Latzka, WA Sawka, MN AF Muza, SR Levine, L Latzka, WA Sawka, MN TI Inspiratory resistance effects on exercise breathing pattern relationships to chemoresponsiveness SO INTERNATIONAL JOURNAL OF SPORTS MEDICINE LA English DT Article DE added inspiratory resistance; chemoreceptors; ventilatory drive; control of breathing; hypercapnic ventilatory response ID VENTILATORY RESPONSES; HUMANS; CO2; DETERMINANT; DRIVE AB This study examined the effects of added inspiratory resistance (R(5) cm H2O . L(-1). s(-1)) on the relationsip between exercise breathing pattern and resting hypercapnic ventilatory responsiveness (HCVR). Twelve men completed an HCVR test and two progressive intensity exercise tasks with minimal (R(0)) and elevated (R(5)) resistance. Peak oxygen uptake, and peak power output were not different, but peak VE was decreased with the R(5) load. Exercise ventilation (VE was tightly coupled to VCO2 (r = 0.97) as was mean inspiratory flow rate (V-T/T-I, r = 0.95), but not duty cycle (T-I/TTOT, r = 0.39). With imposition of R(5), V-T/T-I was depressed (p < 0.05) at mild (similar to 40 % VO(2)peak) to peak exercise intensities, whereas T-I/T-TOT was relatively unaffected. At both moderate (similar to 60 % peak VO2) and peak exercise intensities, VE was positively correlated (r = 0.62, p < 0.05 and r = 0.82, p < 0.01, respectively) to subjects' HCVR, However, when normalized, VE . VCO2-1 was significantly correlated to HCVR only at peak exercise ventilation during the R(0) load. Analysis of the exercise breathing pattern revealed that at both moderate and peak exercise intensities, V-T/T-I was positively correlated to HCVR, but T-I/T-TOT was not. The imposition of R(5) decreased the slope of the relationship between exercise V-T/T-I and HCVR at both moderate and peak exercise intensities, and weakened the positive correlation at the moderate exercise intensity. Our analysis indicates that: 1) the positive correlation between exercise hyperpnea and HCVR is mediated by the mean inspiratory flow rate rather than the duty cycle component of the breathing pattern and, 2) at moderate exercise the relationship between mean inspiratory flow rate and resting HCVR is more sensitive to added inspiratory resistance than minute ventilation per se. These findings suggest that the degree of influence resting HCVR has on exercise hyperpnea is dependent upon the magnitudes of both the ventilatory hyperpnea and mechanical loading placed on the ventilatory system. RP Muza, SR (reprint author), USA,ENVIRONM MED RES INST,KANSAS ST,NATICK,MA 01760, USA. NR 24 TC 0 Z9 0 U1 0 U2 1 PU GEORG THIEME VERLAG PI STUTTGART PA P O BOX 30 11 20, D-70451 STUTTGART, GERMANY SN 0172-4622 J9 INT J SPORTS MED JI Int. J. Sports Med. PD JUL PY 1996 VL 17 IS 5 BP 344 EP 350 DI 10.1055/s-2007-972858 PG 7 WC Sport Sciences SC Sport Sciences GA UZ455 UT WOS:A1996UZ45500006 PM 8858405 ER PT J AU Zak, M Meyers, RE AF Zak, M Meyers, RE TI Non-Newtonian effects in viscous flows SO INTERNATIONAL JOURNAL OF THEORETICAL PHYSICS LA English DT Article AB Revision of the mathematical formalism of fluid dynamics suggests that some physical inconsistencies (infinite time of approaching equilibrium and fully deterministic solutions to the Navier-Stokes equations) can be removed by relaxing the Lipschitz conditions, i.e., the boundedness of the derivatives, in the constitutive equations. Physically such a modification can be interpreted as an incorporation of an infinitesimal static friction in the constitutive law. A modified version of the Navier-Stokes equations is introduced, discussed, and illustrated by examples. It is demonstrated that all the new effects in the modified model emerge within vanishingly small neighborhoods of equilibrium states which are the only domains where the governing equations are different from classical. C1 USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP Zak, M (reprint author), CALTECH,JET PROP LAB,4800 OAK GROVE DR,PASADENA,CA 91109, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0020-7748 J9 INT J THEOR PHYS JI Int. J. Theor. Phys. PD JUL PY 1996 VL 35 IS 7 BP 1423 EP 1460 DI 10.1007/BF02084951 PG 38 WC Physics, Multidisciplinary SC Physics GA VA925 UT WOS:A1996VA92500013 ER PT J AU Knapik, JJ Jones, BH Vogel, JA Banderet, LE Bahrke, MS OConnor, JS AF Knapik, JJ Jones, BH Vogel, JA Banderet, LE Bahrke, MS OConnor, JS TI Influence of age and body mass index on measures of physical fitness in US Army soldiers SO JOURNAL OF AGING AND PHYSICAL ACTIVITY LA English DT Article DE exercise; aerobic capacity; muscular endurance ID HUMAN SKELETAL-MUSCLE; CROSS-SECTIONAL AREA; ISOMETRIC STRENGTH; ELDERLY MEN; ENDURANCE; WOMEN; EXERCISE; PERFORMANCE; YOUNG; RESPONSES AB This study describes associations between age, body mass index (BMI), and performance on three common measures of physical fitness: maximum push-ups in 2 min, maximum sit-ups in 2 min, and 3.2-km run for time. Subjects were 5,346 healthy male soldiers, ages 18 to 53 years. Before age 30, there were few age-related differences between the youngest and the older age groups on any test; after age 30, performance declined as age increased, averaging 16%, 17%, and 7% per decade for push-ups. sit-ups. and the run, respectively. Regression analysis showed that age accounted for 10%, 15% and 9% of the variance ill push-up, sit-up, and run performances, respectively. When BMI was added to the regression model it increased the variance accounted for in the run to 16% (age plus BMI) but did not explain variance in push-ups or sit-ups. There are systematic age-related declines in the performance of push-ups, sit-ups, and 3.2 km running, with age alone accounting for only 9% to 15% of the total performance variance in this sample of healthy men. RP Knapik, JJ (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21010, USA. NR 69 TC 6 Z9 6 U1 0 U2 1 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, CHAMPAIGN, IL 61820-2200 SN 1063-8652 J9 J AGING PHYS ACTIV JI J. Aging Phys. Act. PD JUL PY 1996 VL 4 IS 3 BP 234 EP 250 PG 17 WC Geriatrics & Gerontology; Gerontology; Sport Sciences SC Geriatrics & Gerontology; Sport Sciences GA UV247 UT WOS:A1996UV24700003 ER PT J AU Benney, RJ Stein, KR AF Benney, RJ Stein, KR TI Computational fluid-structure interaction model for parachute inflation SO JOURNAL OF AIRCRAFT LA English DT Article AB In parachute research, the canopy inflation process is the least understood and the most complex to model. Unfortunately it is during the opening process that the canopy often experiences the largest deformations and loadings. The complexity of modeling the opening process stems from the coupling between the structural dynamics of the canopy, lines, and payload with the aerodynamics of the surrounding fluid medium. The addition of a computational capability to model the coupled opening behavior would greatly assist in the understanding of the canopy inflation process. This article describes research that involves coupling a computational fluid dynamics code to a mass spring damper parachute structural code. The axisymmetric codes are coupled with an explicit marching method. The current model is described and results for a round parachute are presented. A comparison of the numerical results to experimental data will be presented. The successful solution of these problems gives us confidence that the computational aeroelastic problem for parachute openings can be solved. This solution allows moving the parachute design process from one of cut and try to one based on experimentally verified computational tools and reduces the reliance on costly and time-consuming testing during development. RP Benney, RJ (reprint author), USA,NATICK RES DEV & ENGN CTR,MOBIL DIRECTORATE,KANSAS ST,NATICK,MA 01760, USA. NR 6 TC 17 Z9 18 U1 0 U2 1 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0021-8669 J9 J AIRCRAFT JI J. Aircr. PD JUL-AUG PY 1996 VL 33 IS 4 BP 730 EP 736 DI 10.2514/3.47008 PG 7 WC Engineering, Aerospace SC Engineering GA VD917 UT WOS:A1996VD91700008 ER PT J AU Cole, MW Eckart, DW Han, WY Pfeffer, RL Monahan, T Ren, F Yuan, C Stall, RA Pearton, SJ Li, Y Lu, Y AF Cole, MW Eckart, DW Han, WY Pfeffer, RL Monahan, T Ren, F Yuan, C Stall, RA Pearton, SJ Li, Y Lu, Y TI Thermal stability of W ohmic contacts to n-type GaN SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID METAL AB W was found to produce low specific contact resistance (rho(c) similar to 8.0X10(-5) Ohm cm(2)) ohmic contacts to n(+)-GaN (n=1.5X10(19) cm(-3)) with limited reaction between the metal and semiconductor up to 1000 degrees C. The formation of the beta-W2N and W-N interfacial phases were deemed responsible for the electrical integrity observed at these annealing temperatures. No Ga out-diffusion was observed on the surface of thin (500 Angstrom) W contacts even after 1000 degrees C, 1 min anneals. Thus, W appears to be a stable contact to n(+)-GaN for high temperature applications. (C) 1996 American Institute of Physics. C1 AT&T BELL LABS,MURRAY HILL,NJ 07974. EMCORE CORP,SOMERSET,NJ 08873. UNIV FLORIDA,GAINESVILLE,FL 32611. RUTGERS STATE UNIV,PISCATAWAY,NJ 08855. RP Cole, MW (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 13 TC 67 Z9 67 U1 0 U2 13 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUL 1 PY 1996 VL 80 IS 1 BP 278 EP 281 DI 10.1063/1.362816 PG 4 WC Physics, Applied SC Physics GA UU532 UT WOS:A1996UU53200041 ER PT J AU Young, AJ Sawka, MN Muza, SR Boushel, R Lyons, T Rock, PB Freund, BJ Waters, R Cymerman, A Pandolf, KB Valeri, CR AF Young, AJ Sawka, MN Muza, SR Boushel, R Lyons, T Rock, PB Freund, BJ Waters, R Cymerman, A Pandolf, KB Valeri, CR TI Effects of erythrocyte infusion on Vo(2max) at high altitude SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE blood doping; exercise; hypoxia; oxygen transport; maximal oxygen uptake ID AEROBIC WORK CAPACITY; EXERCISE; REINFUSION; WOMEN; POWER AB This study investigated whether autologous erythrocyte infusion would ameliorate the decrement in maximal O-2 uptake (VO2max) experienced by lowlanders when they ascend to high altitude. VO2max was measured in 16 men (treadmill running) at sea level (SL) and on the 1st (HA1) and 9th (HA9) days of high-altitude (4,300 m) residence. After VO2max was measured at SL, subjects were divided into two matched groups (n = 8). Twenty-four hours before ascent to high altitude, the experimental group received a 700-ml infusion of autologous erythrocytes and saline (42% hematocrit), whereas the control group received only saline. The VO2max of erythrocyte-infused [54 +/- 1 (SE) ml . kg(-1) . min(-1)] and control subjects (52 +/- 2 ml . kg(-1) . min(-1)) did not differ at SL before infusion. The decrement in VO2max on HA1 did not differ between groups, averaging 26% overall, despite higher (P < 0.001) arterial hematocrit, hemoglobin concentration, and arterial O-2 content in the erythrocyte-infused subjects. By HA9, there were no longer any differences in hematocrit, hemoglobin concentration, or arterial O-2 content between groups. No change in VO2(max) occurred between HA1 and HA9 for either group. Thus, despite increasing arterial O-2-carrying capacity, autologous erythrocyte infusion did not ameliorate the decrement in VO2max at 4,300-m altitude. C1 BOSTON UNIV, MED CTR, USN, BLOOD RES LAB, BOSTON, MA 02118 USA. RP Young, AJ (reprint author), USA, RIEM, THERMAL PHYSIOL & MED DIV, NATICK, MA 01760 USA. NR 23 TC 37 Z9 37 U1 0 U2 6 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD JUL PY 1996 VL 81 IS 1 BP 252 EP 259 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA VA586 UT WOS:A1996VA58600032 PM 8828672 ER PT J AU Bliese, PD Halverson, RR AF Bliese, PD Halverson, RR TI Individual and nomothetic models of job stress: An examination of work hours, cohesion, and well-being SO JOURNAL OF APPLIED SOCIAL PSYCHOLOGY LA English DT Article ID NEGATIVE AFFECTIVITY; PERFORMANCE; HEALTH; LEVEL; LOGIC AB Many models of job stress are implicitly based on the assumption that there is considerable variability in how individuals perceive and respond to their environments. In this paper, we introduce a nomothetic perspective of job stress. The nomothetic perspective assumes that despite individual differences there will be consistencies in how groups of individuals perceive and respond to similar work environments. To contrast the individual and nomothetic perspectives, we analyzed data from 7,382 respondents from 99 groups. In the analyses, we examined individual- and group-level relationships using both real groups and randomly formed groups. The results revealed that respondents from the same work group agreed about perceptions of the work climate. The results also revealed that both individual and nomothetic perspectives were useful in describing the relationship between cohesion and psychological well-being. The relationship between work hours and psychological well-being, however, was best modeled from a nomothetic perspective. RP Bliese, PD (reprint author), WALTER REED ARMY INST RES,WASHINGTON,DC 20307, USA. NR 40 TC 91 Z9 91 U1 4 U2 9 PU V H WINSTON & SON INC PI PALM BEACH PA 360 SOUTH OCEAN BLVD, PH-B, PALM BEACH, FL 33480 SN 0021-9029 J9 J APPL SOC PSYCHOL JI J. Appl. Soc. Psychol. PD JUL 1 PY 1996 VL 26 IS 13 BP 1171 EP 1189 DI 10.1111/j.1559-1816.1996.tb02291.x PG 19 WC Psychology, Social SC Psychology GA UX145 UT WOS:A1996UX14500004 ER PT J AU Reddy, TV Olson, GR Wiechman, B Reddy, G Robinson, M Torsella, JA Daniel, FB AF Reddy, TV Olson, GR Wiechman, B Reddy, G Robinson, M Torsella, JA Daniel, FB TI Fourteen-day toxicity study of 1,3,5-trinitrobenzene in Fischer 344 rats SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE 1,3,5-trinitrobenzene; nitroaromatic compounds; methemoglobin; subacute toxicity ID TRINITROTOLUENE AB Toxic effects of 1,3,5-trinitrobenzene (TNB) in male and female rats were evaluated by feeding powdered certified laboratory chow diet supplemented with varied concentrations of TNB (0, 50, 200, 400, 800 and 1200 mg kg(-1) diet) for 14 days, Food intake by female rats in 400, 800 and 1200 mg TNB diet groups was reduced and resulted in a significant decrease in absolute body weights (BW). Food and water consumption by male rats in high-dose groups (800 and 1200 mg TNB kg(-1) diet) was also reduced and resulted in a significant decrease in body weight, The calculated average TNB intake (from 1200 mg TNB kg(-1) diet) was 92 mg kg(-1) BW day(-1) for male rats and 80 mg kg(-1) BW day(-1) for females, A decrease in testicular weight in males and an increase in spleen weight of both sexes in high-dose groups was noted, In addition, histopathological examinations revealed that the susceptible organs for TNB toxicity were kidney (hyaline droplets), spleen (extramedullary hematopoiesis), brain (hemorrhage, malacia and gliosis) and testes (seminiferous tubular degeneration), Hematology and clinical chemistry studies indicated a decrease in red blood cell count and hematocrit, a decrease in alkaline phosphatase, an increase in Heinz bodies and increased methemoglobin concentration as compared to controls in both sexes, A lowest observed adverse effect level of 4.41 mg TNB kg(-1) BW day(-1) was established based on the findings of this study. C1 PATHOL ASSOCIATES INC,W CHESTER,OH 45069. USA,BIOMED RES & DEV LAB,FREDERICK,MD 21702. US EPA,ENVIRONM MONITORING SYST LAB,CINCINNATI,OH 45268. RP Reddy, TV (reprint author), US EPA,ENVIRONM MONITORING SYST LAB,CINCINNATI,OH 45268, USA. NR 18 TC 10 Z9 10 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD JUL-AUG PY 1996 VL 16 IS 4 BP 289 EP 295 DI 10.1002/(SICI)1099-1263(199607)16:4<289::AID-JAT349>3.0.CO;2-I PG 7 WC Toxicology SC Toxicology GA VA766 UT WOS:A1996VA76600002 PM 8854214 ER PT J AU Nelson, LS Getsinger, KD Freedman, JE AF Nelson, LS Getsinger, KD Freedman, JE TI Efficacy of triclopyr on purple loosestrife and associated wetland vegetation SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article ID LYTHRUM-SALICARIA L; BIOLOGY RP Nelson, LS (reprint author), USA,WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 8 TC 2 Z9 2 U1 0 U2 0 PU AQUATIC PLANT MANAGEMENT SOC, INC PI CLERMONT PA PO BOX 121086, CLERMONT, FL 34712-1086 SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 1996 VL 34 BP 72 EP 74 PG 3 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA VL343 UT WOS:A1996VL34300008 ER PT J AU Pless, DD Wellner, RB AF Pless, DD Wellner, RB TI In vitro fusion of endocytic vesicles: Effects of reagents that alter endosomal pH SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Article DE ricin; transferrin; monensin; bafilomycin A1; chloroquine ID CELL-FREE SYSTEM; RECEPTOR-MEDIATED ENDOCYTOSIS; RICIN A-CHAIN; PSEUDOMONAS TOXIN; DIPHTHERIA-TOXIN; H+-ATPASE; MECHANISM; INVITRO; ACIDIFICATION; MEMBRANE AB Ricin, a plant toxin that binds to galactose-terminated glycoproteins and glycolipids on the cell surface, is internalized into endosomes before reaching the cytosol where it exerts its toxic activity. Fusion of early endosomes containing ricin or transferrin was demonstrated by using postnuclear supernatant fractions from K-562 cells. For both ligands, fusion depended on time, temperature, and ATP and was blocked by preincubation with N-ethylmaleimide. Some reagents that increase endosomal pH, the ionophores monensin and nigericin and the weak base chloroquine, stimulated the rate of fusion. However, bafilomycin A(1), a specific inhibitor of vacuolar H+-ATPases, did not alter the rate of fusion. Moreover, it reduced or eliminated stimulation caused by monensin, nigericin, or chloroquine. Thus, the increased rate of fusion did not correlate with the higher lumenal pH of the endosome. The results suggest instead that fusion was stimulated by reagents that promoted accumulation of cations within the vesicles. (C) 1996 Wiley-Liss, Inc.* C1 USA, MED RES INST INFECT DIS, DIV TOXINOL, DEPT BIOCHEM & CELL BIOL, FREDERICK, MD 21702 USA. NR 55 TC 30 Z9 30 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-2312 EI 1097-4644 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD JUL PY 1996 VL 62 IS 1 BP 27 EP 39 DI 10.1002/(SICI)1097-4644(199607)62:1<27::AID-JCB4>3.0.CO;2-3 PG 13 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA UZ522 UT WOS:A1996UZ52200004 PM 8836873 ER PT J AU Shafer, RW Winters, MA Mayers, DL Japour, AJ Kuritzkes, DR Weislow, OS White, F Erice, A Sannerud, KJ Iversen, A Pena, F Dimitrov, D Frenkel, LM Reichelderfer, PS AF Shafer, RW Winters, MA Mayers, DL Japour, AJ Kuritzkes, DR Weislow, OS White, F Erice, A Sannerud, KJ Iversen, A Pena, F Dimitrov, D Frenkel, LM Reichelderfer, PS TI Interlaboratory comparison of sequence-specific PCR and ligase detection reaction to detect a human immunodeficiency virus type 1 drug resistance mutation SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID ZIDOVUDINE RESISTANCE; REVERSE-TRANSCRIPTASE AB Sequence-specific PCR was used in six laboratories and a ligase detection reaction was used in one laboratory to detect the zidovudine-resistance mutation at codon 215 of human immunodeficiency virus type 1 (HIV-I) reverse transcriptase DNA. The genotypes of 27 different clinical samples, including cultured HIV-1 isolates, peripheral blood mononuclear cells, and plasma, were correctly identified by 140 of 154 (91%) assays. The sensitivity for detecting a mutation was 96% for HIV-1 reverse transcriptase DNA clone mixtures containing 30% mutant DNA and 62% for mixtures containing 6% mutant DNA. C1 NIAID,DIV AIDS,NIH,DDSCB,BETHESDA,MD 20892. STANFORD UNIV,STANFORD,CA 94305. WALTER REED ARMY INST RES,ROCKVILLE,MD. UNIV COLORADO,DENVER,CO 80202. BETH ISRAEL HOSP,BOSTON,MA 02215. UNIV MINNESOTA,MINNEAPOLIS,MN 55455. UNIV MIAMI,MIAMI,FL 33152. BAYLOR COLL MED,HOUSTON,TX 77030. UNIV WASHINGTON,SEATTLE,WA 98195. NR 21 TC 6 Z9 6 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JUL PY 1996 VL 34 IS 7 BP 1849 EP 1853 PG 5 WC Microbiology SC Microbiology GA UR416 UT WOS:A1996UR41600058 PM 8784610 ER PT J AU Czuszak, CA Sutherland, DE Billman, MA Stein, SH AF Czuszak, CA Sutherland, DE Billman, MA Stein, SH TI Prostaglandin E(2) potentiates interleukin-1 beta induced interleukin-6 production by human gingival fibroblasts SO JOURNAL OF CLINICAL PERIODONTOLOGY LA English DT Article DE interleukin-6; interleukin-1 beta; prostaglandin-E(2); indomethacin; gingival fibroblasts; periodontitis; inflammation ID HUMAN PERIODONTAL-LIGAMENT; ALVEOLAR BONE LOSS; CREVICULAR FLUID; ACTIVATING FACTOR; CYCLIC-AMP; DISEASE; RESORPTION; CYTOKINES; MESSENGER; TISSUES AB Increased levels of cytokines and prostanoids have been detected in inflamed gingival tissue and may play an important role in periodontal pathogenesis. Recent studies suggest that monocytic products, such as interleukin (IL)-1 beta, could stimulate IL-6 production by human gingival fibroblasts (HGF). In this context, the production of local cytokines and inflammatory mediators could regulate the secretory capacity of resident gingival fibroblasts. Therefore, the purpose of this study was to determine if PGE(2) induced by IL-1 beta could potentiate the IL-6 response by HGF. Utilizing an ELISA, it was determined that maximal IL-6 occurred when HGF were stimulated with 0.10-10 nM IL-1 beta. These concentrations of IL-1 beta also induced a small, but significant increase in PGE(2) production by HGF. Interestingly, the combination of IL gamma beta and PGE(2) induced a synergistic rise in IL-6 production by HGF. Moreover, inclusion of indomethacin caused a 20% reduction in IL-6 production and totally eliminated PGE(2) production. These findings provide additional rationale for the clinical use of NSAIDs in the management of periodontal disease due to their ability to attenuate production of both PGE(2), and IL-6. These results suggest the endogenous PGE(2) induced by IL-1 beta plays an important regulatory role in IL 6 production by HGF. Moreover, they support the concept that elevated PGE(2)induced during inflammation can regulate HGF secretory function. C1 USA,DENT ACTIV & EISENHOWER ARMY MED CTR,FT GORDON,GA. MED COLL GEORGIA,SCH DENT,DEPT ORAL BIOL & PERIODONT,AUGUSTA,GA 30912. RP Czuszak, CA (reprint author), FT LEONARD WOOD ARMY MED CTR,FT LEONARD WOOD,MO 65473, USA. NR 38 TC 20 Z9 24 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0303-6979 J9 J CLIN PERIODONTOL JI J. Clin. Periodontol. PD JUL PY 1996 VL 23 IS 7 BP 635 EP 640 DI 10.1111/j.1600-051X.1996.tb00587.x PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA UY467 UT WOS:A1996UY46700005 PM 8841895 ER PT J AU Stumpf, AL Ganeshan, R Chin, SY Liu, LY AF Stumpf, AL Ganeshan, R Chin, SY Liu, LY TI Object-oriented model for integrating construction product and process information SO JOURNAL OF COMPUTING IN CIVIL ENGINEERING LA English DT Article AB Product and process models provide the necessary information framework for implementing computer systems for the architect/engineering/construction (A/E/C) industry. Although the focus of these models is slightly different, both are needed to provide a foundation for managing project information during the design and construction phases. Design information-''product'' information based on building components-needs to be integrated with construction management tasks, the ''process'' information necessary to build the components. It is therefore important to provide an integrated information model to bridge the gap between product and process information for a construction project, An integrated information model not only encourages those involved in construction to use and add to design information, but also provides richer information representation, better efficiency and data consistency, and the flexibility to support life-cycle information management. The research presented in this paper was performed under the auspices of the collaborative engineering research program at the U.S. Army Corps of Engineers Construction Engineering Research Laboratories (USACERL), which is attempting to redefine existing design processes to make them more collaborative and to develop enabling technologies to support the new process. An important part of this research is the development of an integrated information model that allows agents to communicate/collaborate over the life cycle of the project. This paper presents an object-oriented model that integrates product and process information to support collaboration among design and construction agents, and two prototype construction agents for construction planning and monitoring project progress. The development of these two agents demonstrates the value of using integrated product and process models for managing facility information in the A/E/C industry. C1 UNIV ILLINOIS,DEPT CIVIL ENGN,CHAMPAIGN,IL 61801. RP Stumpf, AL (reprint author), USA,CONSTRUCT ENGN RES LAB,POB 9005,CHAMPAIGN,IL 61826, USA. OI Chin, Sangyoon/0000-0002-4639-9649 NR 30 TC 25 Z9 26 U1 0 U2 7 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0887-3801 J9 J COMPUT CIVIL ENG JI J. Comput. Civil. Eng. PD JUL PY 1996 VL 10 IS 3 BP 204 EP 212 DI 10.1061/(ASCE)0887-3801(1996)10:3(204) PG 9 WC Computer Science, Interdisciplinary Applications; Engineering, Civil SC Computer Science; Engineering GA UT001 UT WOS:A1996UT00100005 ER PT J AU Ketcham, SA Niemiec, JM McKenna, GB AF Ketcham, SA Niemiec, JM McKenna, GB TI Extension and compression of elastomeric butt joint seals SO JOURNAL OF ENGINEERING MECHANICS-ASCE LA English DT Article ID RUBBER; BEHAVIOR; NETWORKS; STRAIN AB The conventional practice for the design of elastomeric butt joint seals in pavement and building expansion joints is based primarily on standard tests of model seals. The practice does not incorporate structural analysis and does not utilize mechanical properties of the sealant. This study concerns the applicability of a particular load versus deflection equation for the extension and compression design of these seals, i.e., the elementary large compression equation suggested by Payne in 1956 and Gent and Lindley in 1959 for bonded rubber blocks. The study demonstrates, using experiments to measure strain energy density functions for two sealants, by application of these functions in finite-element analyses and by comparison of the finite-element and elementary analysis results, the capabilities and limitations of the load versus deflection equation. In the process, the study introduces an efficient experimental technique for evaluating coefficients of the Rivlin strain energy density polynomial for general application to the analysis of elastomeric structures, and demonstrates the utility of the finite-element-based approach for extension and compression analysis of buff joint seals. C1 NATL INST STAND & TECHNOL,DIV POLYMERS,STRUCT & MECH GRP,GAITHERSBURG,MD 20899. RP Ketcham, SA (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. RI McKenna, Gregory/O-1134-2013 OI McKenna, Gregory/0000-0002-5676-9930 NR 21 TC 6 Z9 6 U1 0 U2 3 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9399 J9 J ENG MECH-ASCE JI J. Eng. Mech.-ASCE PD JUL PY 1996 VL 122 IS 7 BP 669 EP 677 DI 10.1061/(ASCE)0733-9399(1996)122:7(669) PG 9 WC Engineering, Mechanical SC Engineering GA UR831 UT WOS:A1996UR83100009 ER PT J AU Dalsgaard, A Bjergskov, T Jeppesen, VF Jorgensen, LB Echeverria, P Dalsgaard, I AF Dalsgaard, A Bjergskov, T Jeppesen, VF Jorgensen, LB Echeverria, P Dalsgaard, I TI Prevalence and characterization of Vibrio cholerae isolated from shrimp products imported into Denmark SO JOURNAL OF FOOD PROTECTION LA English DT Article DE Vibrio cholerae; seafood; serology; cholera toxin; heat-stable enterotoxin ID PRODUCTION AREA; TOXIN; SEROGROUPS; THAILAND; NON-O1 AB A total of 3,555 metric tonnes of warm water shrimp were imported into Denmark from December 1994 to July 1995. V. cholerae O1 was not detected in any of the 748 samples analyzed. Non-Ol V. cholerae was found in a single (0.1%) cooked frozen shrimp product and in five (0.7%) raw frozen products, all originating from shrimp produced in aquaculture. Six isolated strains agglutinated in polyvalent O antisera, but did not agglutinate in Ogawa or Inaba antisera. The six strains were resistant to colistin and sulfisoxazole; three strains also showed resistance to ampicillin. None of the strains contained plasmids or genes encoding cholera toxin (CT) or heat-stable enterotoxin (NAG-ST), The absence of V. cholerae O1 and the low number of samples containing CT and NAG-ST negative non-Ol strains in imported shrimp suggest that I! cholerae in such products may not constitute a public health problem. C1 ROYAL VET & AGR UNIV,DANISH INST FISHERIES RES,FISH DIS LAB,DK-1870 FREDERIKSBERG C,DENMARK. ROYAL VET & AGR UNIV,DEPT VET MICROBIOL,DK-1870 FREDERIKSBERG C,DENMARK. MINIST AGR & FISHERIES,DANISH VET SERV,DK-1870 FREDERIKSBERG C,DENMARK. TECH UNIV DENMARK,DEPT SEAFOOD RES,DANISH INST FISHERIES RES,MINIST AGR & FISHERIES,ANALYT LAB,DK-2800 LYNGBY,DENMARK. ARMED FORCES RES INST MED SCI,BANGKOK 10400,THAILAND. NR 17 TC 9 Z9 10 U1 0 U2 0 PU INT ASSOC MILK FOOD ENVIRONMENTAL SANITARIANS, INC PI DES MOINES PA 6200 AURORA AVE SUITE 200W, DES MOINES, IA 50322-2838 SN 0362-028X J9 J FOOD PROTECT JI J. Food Prot. PD JUL PY 1996 VL 59 IS 7 BP 694 EP 697 PG 4 WC Biotechnology & Applied Microbiology; Food Science & Technology SC Biotechnology & Applied Microbiology; Food Science & Technology GA UZ348 UT WOS:A1996UZ34800003 ER PT J AU Jean, IJ Work, R Camire, ME Briggs, J Barrett, AH Bushway, AA AF Jean, IJ Work, R Camire, ME Briggs, J Barrett, AH Bushway, AA TI Selected properties of extruded potato and chicken meat SO JOURNAL OF FOOD SCIENCE LA English DT Article DE extrusion; chicken; instant potato; snack ID SINGLE-SCREW EXTRUSION; CORN MEAL; STARCH; PROTEIN; COOKING; FLOUR; DISTRIBUTIONS; TEMPERATURE; EXPANSION; VARIABLES AB Chicken thigh meat (CTM), (0-40%) was mixed with instant mashed potato and twin-screw extruded. Feed moisture content (FMC), (15 or 20%) and screw speed (SS) (250 or 300 rpm) were varied. CTM affected expansion, bulk density, mean cell size, plateau stress, fracturability and solubility. Protein, fat, free fatty acid and ash increased and carbohydrate decreased as CTM increased. Extrudates produced at low feed moisture (15%) had higher compressive resistance, fracturability and solubility. Extrudates produced at high feed moisture (20%) had higher bulk density and mean cell size. Screw speed had no influence except on expansion degree (p less than or equal to 0.05). Increased CTM changed microstructure from rough, thread-like sheers to a flat, agglomerated carbohydrate-protein laminar phase. Panelists reported no differences in overall acceptability among 0% CTM extruded at 20% FMC, 20% CTM extruded at 15% FMC and 20% CTM extruded at 20% FMC. C1 UNIV MAINE,DEPT FOOD SCI & HUMAN NUTR,ORONO,ME 04469. USA,NRDC,AFB,TAD,FED,NATICK,MA 01760. NR 42 TC 9 Z9 10 U1 0 U2 0 PU INST FOOD TECHNOLOGISTS PI CHICAGO PA SUITE 300 221 N LASALLE ST, CHICAGO, IL 60601-1291 SN 0022-1147 J9 J FOOD SCI JI J. Food Sci. PD JUL-AUG PY 1996 VL 61 IS 4 BP 783 EP 789 DI 10.1111/j.1365-2621.1996.tb12203.x PG 7 WC Food Science & Technology SC Food Science & Technology GA VB466 UT WOS:A1996VB46600026 ER PT J AU Miller, PS AF Miller, PS TI Disturbances in the soil: Finding buried bodies and other evidence using ground penetrating radar SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE forensic science; ground penetrating radar; remote sensing; archaeology ID ARCHAEOLOGICAL INVESTIGATIONS; GRAVES AB Ground penetrating radar (GPR) is an efficient and effective means to search for buried evidence, whether it be a clandestine grave, formal burial, or certain missing articles from a crime scene. The procedures for GPR used by the U.S. Army Central Identification Laboratory, Hawaii (CILHI), are the result of several years of experimentation on a variety of ground surfaces in Hawaii, Southeast Asia and the mainland U.S. This remote sensing method does not usually provide direct information that there is a body or other specific object beneath the ground. Most of the time the GPR has been used to determine where a target object is not located. The key feature of GPR is that it can detect recent changes in shallow soil conditions caused by the disturbance of soil and the intrusion of different material. Using the methods described here, the investigator should be able to determine the precise metric grid coordinates for a subsurface disturbance, as well as the approximate size, the general shape, and the depth of the buried material. Success will vary with soil conditions. The conditions suitable or not practical for using GPR are summarized. This remote sensing technology can have wider use in crime scene investigations due to the recent introduction of more user-friendly software and more portable hardware. RP Miller, PS (reprint author), USA,CENT IDENTIFICAT LAB,310 WORCHESTER AVE,HICKAM AFB,HI 96853, USA. NR 20 TC 20 Z9 20 U1 2 U2 22 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD JUL PY 1996 VL 41 IS 4 BP 648 EP 652 PG 5 WC Medicine, Legal SC Legal Medicine GA UW195 UT WOS:A1996UW19500026 PM 8754575 ER PT J AU Charlie, WA Taylor, T Brownell, KC AF Charlie, WA Taylor, T Brownell, KC TI Model studies of effects on lunar soil of chemical explosions - Discussion SO JOURNAL OF GEOTECHNICAL ENGINEERING-ASCE LA English DT Editorial Material C1 UNIV WASHINGTON,SEATTLE,WA 98195. USA,CORPS ENGINEERS,SEATTLE,WA 98124. RP Charlie, WA (reprint author), COLORADO STATE UNIV,FT COLLINS,CO 80523, USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9410 J9 J GEOTECH ENG-ASCE JI J. Geotech. Eng.-ASCE PD JUL PY 1996 VL 122 IS 7 BP 601 EP 601 DI 10.1061/(ASCE)0733-9410(1996)122:7(601) PG 1 WC Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA UT695 UT WOS:A1996UT69500010 ER PT J AU Zelenka, RE Clark, RF Zirkler, A Saari, R Branigan, RG AF Zelenka, RE Clark, RF Zirkler, A Saari, R Branigan, RG TI Development and flight test of terrain-referenced guidance with ladar forward sensor SO JOURNAL OF GUIDANCE CONTROL AND DYNAMICS LA English DT Article AB Military aircraft regularly conduct missions that include low-altitude, near-terrain flight to increase covertness and payload effectiveness. Civilian aircraft operate in this regime during airborne fire fighting, police surveillance, search and rescue, and helicopter emergency medical service applications. Several fixed-wing aircraft now employ terrain elevation maps and forward-pointed radars to achieve automated terrain following or terrain avoidance flight. Similar systems specialized to helicopters and their flight regime have not received as much attention. A helicopter guidance system relying on digitized terrain elevation maps has been developed that employs airborne. navigation, mission requirements, aircraft performance limits, and radar altimeter returns to generate a valley-seeking, low-altitude trajectory between waypoints. The guidance trajectory is symbolically presented to the pilot on a helmet-mounted display. In this work, a wide field of view laser radar forward sensor has been incorporated into this guidance system to expand the system's operational flight envelope and to assist the pilot in obstacle detection and avoidance. The development and flight test results of this guidance system are presented. Missions to 75 ft altitude at 80 kn in the presence of unmapped natural and man-made obstacles were achieved while the pilot maintained situational awareness and tracking of the guidance trajectory. C1 USA COMMAND,CONTROL & SYST INTEGRAT DIRECTORATE,SYST DEV BRANCH,FT MONMOUTH,NJ 07703. UNIXPROS,EATONTOWN,NJ 07724. USA,NIGHT VIS & ELECT SENSOR SYST DIRECTORATE,AIRBORNE APPLICAT BRANCH,FT BELVOIR,VA 22060. RP Zelenka, RE (reprint author), NASA,AMES RES CTR,FLIGHT DECK BRANCH,M-S 262-3,MOFFETT FIELD,CA 94035, USA. NR 10 TC 4 Z9 4 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0731-5090 J9 J GUID CONTROL DYNAM JI J. Guid. Control Dyn. PD JUL-AUG PY 1996 VL 19 IS 4 BP 823 EP 828 DI 10.2514/3.21705 PG 6 WC Engineering, Aerospace; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA UV695 UT WOS:A1996UV69500011 ER PT J AU Freedman, DL Shanley, RS Scholze, RJ AF Freedman, DL Shanley, RS Scholze, RJ TI Aerobic biodegradation of 2,4-dinitrotoluene, aminonitrotoluene isomers, and 2,4-diaminotoluene SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE aerobic biodegradation; diaminotoluene; dinitrotoluene ID NITROAROMATIC COMPOUNDS; MICROBIAL TRANSFORMATION; ACTIVATED-SLUDGE; BIOTRANSFORMATION; IDENTIFICATION AB 2,4-Dinitrotoluene (DNT) is widely used in industry, including the manufacture of propellants. 2,4-Diaminotoluene (DAT), 2-amino-4-nitrotoluene (2A4NT), and 4-amino-2-nitrotoluene (4A2NT) are among the products that can result from biological treatment of DNT. The objective of this study was to examine the biodegradability of these hazardous compounds. Using an inoculum from a munitions wastewater treatment plant, enrichment cultures were developed that readily consumed DAT, 4A2NT, 2A4NT, and DNT when they were provided as sole organic substrates (84-100 mg 1(-1)) or when ethanol (600 mg 1(-1)) was added as a cosubstrate. Low effluent chemical oxygen demand (COD) levels suggested that the aromatics were mineralized, rather than simply transformed to other possibly hazardous compounds. The addition of ether (142 mg 1(-1)) as a cosubstrate had no significant effect on the biodegradation of DAT and 4A2NT, but did inhibit the consumption of DNT and 2A4NT. The presence of ether in munitions wastewater may therefore present a challenge to effective biological treatment. When DNT was added to enrichment cultures as sole substrate, nitrite was released stoichiometrically. However, when ethanol was also added, nitrite release was only 59% of the maximum, indicating that most of the DNT was reduced prior to ring cleavage. When provided to enrichment cultures as the sole substrates, the observed yield coefficients for the aromatic compounds ranged from 0.10 to 0.28 mg of volatile suspended solids per mg COD. C1 USA,CONSTRUCT ENGN RES LABS,CHAMPAIGN,IL 61821. RP Freedman, DL (reprint author), UNIV ILLINOIS,DEPT CIVIL ENGN,URBANA,IL 61801, USA. NR 23 TC 14 Z9 14 U1 2 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD JUL PY 1996 VL 49 IS 1 BP 1 EP 14 DI 10.1016/0304-3894(96)01756-6 PG 14 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA VC086 UT WOS:A1996VC08600001 ER PT J AU Davis, TA Wiesmann, W Kidwell, W Cannon, T Kerns, L Serke, C Delaplaine, T Pranger, A Lee, KP AF Davis, TA Wiesmann, W Kidwell, W Cannon, T Kerns, L Serke, C Delaplaine, T Pranger, A Lee, KP TI Effect of spaceflight on human stem cell hematopoiesis: Suppression of erythropoiesis and myelopoiesis SO JOURNAL OF LEUKOCYTE BIOLOGY LA English DT Article DE weightlessness microgravity; bone marrow cells; anemia; antigen-differentiation; red blood cells ID TUMOR-NECROSIS-FACTOR; FACTOR-ALPHA; PROGENITOR CELLS; IMMUNE CHANGES; SPACE-FLIGHT; BFU-E; GROWTH; MICROENVIRONMENT; MECHANISM; RECEPTORS AB Humans subjected to periods of microgravity develop anemia, thrombocytopenia, and abnormalities in red blood cell structure, The causes of these abnormalities are complex and unclear, The in vitro effects of spaceflight on hematopoietic cell proliferation and differentiation were investigated during the space shuttle missions STS-63 (Discovery) and STS-69 (Endeavour). CD34(+) bone marrow progenitor cells were cultured in liquid suspension culture and on hematopoietic supportive stromal cells using hollow-fiber culture modules, One set of cultures was maintained at microgravity (flight cultures) for the last 8-10 days of culture and a second control was at full gravity (ground control), Over the 11- to 13-test-day period, ground control culture total cell number increased 41.0- to 65.5-fold but flight culture total cell number increased only 10.1- to 11.6-fold (51-84% decrease), Comparing ground control cultures and microgravity cultures, respectively, for progenitor cell content, myeloid progenitor cell numbers expanded 2.6- to 17.5-fold compared with 0.9- to 7.0-fold and erythroid progenitor cell numbers expanded 2.0- to 4.1-fold in ground control cultures but actually declined at microgravity (> 83% reduction), Moreover, microgravity cultures demonstrated accelerated maturation/differentiation toward the macrophage lineage, These data indicate that spaceflight has a direct effect on hematopoietic progenitor cell proliferation and differentiation and that specific aspects of in vitro hematopoiesis, particularly erythropoiesis, involve gravity-sensitive components. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT SPACE BIOSCI,WASHINGTON,DC 20307. CELLCO INC,GERMANTOWN,MD. RP Davis, TA (reprint author), USN,MED RES INST,IMMUNE CELL BIOL PROGRAM,STEM CELL BIOL BRANCH,BLDG 18,ROOM 230,BETHESDA,MD 20889, USA. NR 37 TC 38 Z9 44 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0741-5400 J9 J LEUKOCYTE BIOL JI J. Leukoc. Biol. PD JUL PY 1996 VL 60 IS 1 BP 69 EP 76 PG 8 WC Cell Biology; Hematology; Immunology SC Cell Biology; Hematology; Immunology GA UX998 UT WOS:A1996UX99800008 PM 8699125 ER PT J AU Todd, MJ AF Todd, MJ TI 21st century leadership and technology SO JOURNAL OF MANAGEMENT IN ENGINEERING LA English DT Article AB Leadership, technology, and engineering must come together to allow the United States to retain its greatness in the 21st century. Early engineering leadership considers the Corps of Engineers' assistance in developing the nation's infrastructure, Engineering/scientific leadership and technological innovation are key to everyone's quality of life and the nation's global competitiveness. Discoveries/innovations and their expanded and improved applications have become more and more dramatic-from steam engines to extraterrestrial travel and lunar exploration. Because of continued and dramatic future breakthroughs of an ever-accelerating rate, leaders must understand and manage technological change to help the nation be globally competitive. United States history clearly points to the need for its leaders to adequately prepare for this tremendous and ever-accelerating change, especially in this technological and global age. Engineers and scientists must be the future leaders. As such, they must be better educated in the broader issues affected by technology while not compromising their technical competence. Engineers and scientists will lead, participate in, and guide interdisciplinary teams, and be the decision-makers both in business and government in the 21st century. RP Todd, MJ (reprint author), USA,CORPS ENGINEERS,111 N CANAL ST,CHICAGO,IL 60606, USA. NR 56 TC 3 Z9 3 U1 0 U2 2 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0742-597X J9 J MANAGE ENG JI J. Manage. Eng. PD JUL-AUG PY 1996 VL 12 IS 4 BP 40 EP 49 DI 10.1061/(ASCE)0742-597X(1996)12:4(40) PG 10 WC Engineering, Industrial; Engineering, Civil SC Engineering GA UT004 UT WOS:A1996UT00400023 ER PT J AU Choi, CS Staker, M AF Choi, CS Staker, M TI Neutron diffraction texture study of deformed uranium plates SO JOURNAL OF MATERIALS SCIENCE LA English DT Article AB The texture of two depleted uranium (DU) samples, labelled DUWR and DUWR2, were studied by neutron diffraction. DUWR was prepared by warm rolling of a cast ingot, and DUWR2 was prepared by adding 20% tensile strain to the warm-rolled DUWR. Complete three-dimensional orientation distribution functions were determined using four neutron pole figures for the DUWR, and using six neutron pole figures for the DUWR2 sample, by the WIMV method of the program popLA. The textures of the two samples were essentially identical to each other. They could be described by a twisted helical density tube spiralling continuously along the psi-axis of the Euler space. The projection of the backbone of the density tube along the theta-axis cast a linear shadow running parallel to the diagonal of the phi-psi plane, which could be defined by a phi = psi + 90 degrees (and phi = psi + 270 degrees) relation. The helical tube was confined with in narrow theta-angle limits, from 14 degrees to 30 degrees with the peak orientation at (103) [010]. The diffraction patterns of the DUWR2 sample were measured from the normal direction to the rolling surface of the sample, up to the scattering angle of 108 degrees using a 0.15 nm neutron beam. The Rietveld profile refinement using the textured diffraction pattern was quite satisfactory when the texture effect to the entire diffraction profile was corrected for by the corresponding pole density from the inverse pole figure. C1 NIST,DIV REACTOR RADIAT,GAITHERSBURG,MD 20899. USA,RES LAB,ABERDEEN PROVING GROUND,MD. RP Choi, CS (reprint author), ARDEC,ENERGET & WARHEADS DIV,PICATINNY ARSENAL,NJ 07806, USA. NR 8 TC 9 Z9 9 U1 0 U2 4 PU CHAPMAN HALL LTD PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8HN SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD JUL 1 PY 1996 VL 31 IS 13 BP 3397 EP 3402 PG 6 WC Materials Science, Multidisciplinary SC Materials Science GA UX695 UT WOS:A1996UX69500008 ER PT J AU Frances, SP Klein, TA Hildebrandt, DW Burge, R Noigamol, C Eikarat, N Sripongsai, B Wirtz, RA AF Frances, SP Klein, TA Hildebrandt, DW Burge, R Noigamol, C Eikarat, N Sripongsai, B Wirtz, RA TI Laboratory and field evaluation of deet, CIC-4, and AI3-37220 against Anopheles dirus (Diptera: Culicidae) in Thailand SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Anopheles dirus; diethyl methylbenzamide; (2-hydroxymethylcyclohexyl) acetic acid lactone; 1-(3-cyclohexen-1-yl-carbonyl)-2-methylpiperidine; Thailand ID REPELLENTS AB Laboratory and field tests of the repellents diethyl methylbenzamide (deet), 1-(3-Cyclohexen-1-yl-carbonyl)-2-methylpiperidine (AI3-37220), and (2-hydroxymethylcyclohexyl) acetic acid lactone (CIC-4) were conducted against Anopheles dirus Peyton & Harrison, the principal malaria vector in Thailand. In the laboratory, An. dirus was more sensitive to CIC-4 than either AI3-37220 or deet. The duration of protection provided by each repellent in laboratory tests increased with higher concentrations of repellents and when exposed in cages containing fewer mosquitoes. A field study in Chanthaburi Province, southeastern Thailand, during November 1993 tested 25% (wt:wt) ethanol solutions of each repellent against An. dirus. In contrast to the laboratory experiments, protection provided by AI3-37220 was significantly better than either deet or CIC-4 and there was no significant difference between deer and CIC-4. Protection provided by deer and CIC-4 fell to below 95% 2 h after repellent application, whereas AI3-37220 provided >95% protection for 4 h. The protection provided by all repellents fell to less than or equal to 65% 7 h after repellent application. C1 ARMED FORCES RES INST MED SCI,USA MED COMPONENT,DEPT ENTOMOL,BANGKOK 10400,THAILAND. WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. SC JOHNSON & SON INC,RACINE,WI 53403. WALTER REED ARMY INST RES,DEPT BIOMETR,WASHINGTON,DC 20307. NR 18 TC 28 Z9 29 U1 2 U2 3 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD JUL PY 1996 VL 33 IS 4 BP 511 EP 515 PG 5 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA UT917 UT WOS:A1996UT91700001 PM 8699442 ER PT J AU RUDD, GW AF RUDD, GW TI NO MARGIN FOR ERROR - THE MAKING OF THE ISRAELI-AIR-FORCE - YONAY,E SO JOURNAL OF MILITARY HISTORY LA English DT Book Review RP RUDD, GW (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU VIRGINIA MILITARY INST PI LEXINGTON PA LEXINGTON, VA 24450 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 1996 VL 60 IS 3 BP 582 EP 584 DI 10.2307/2944560 PG 3 WC History SC History GA UY496 UT WOS:A1996UY49600044 ER PT J AU Mirotznik, MS Prather, DW Mait, JN AF Mirotznik, MS Prather, DW Mait, JN TI A hybrid finite element boundary element method for the analysis of diffractive elements SO JOURNAL OF MODERN OPTICS LA English DT Article; Proceedings Paper CT Workshop on Diffractive Optics CY AUG, 1995 CL PRAGUE, CZECH REPUBLIC ID ELECTROMAGNETIC SCATTERING AB We apply a two-dimensional hybrid finite element-boundary element method to the analysis of diffractive optical elements (DOEs). We use the finite element method to solve Helmholtz's equation in the interior of a DOE and use the boundary element method, a Green's function approach, to determine the fields exterior to the DOE. We couple the two methods at the DOE surface by enforcing field continuity conditions. We validate our implementation by comparing its results to the analytic solution for diffraction from a dielectric cylinder and to the scalar solution for far-field diffraction from a dielectric slab. We use the hybrid method to analyse the diffraction from an eight-level phase lens and a binary-phase lens that has subwavelength features. C1 USA,RES LAB,AMSRL,SE,EO,ADELPHI,MD 20783. RP Mirotznik, MS (reprint author), CATHOLIC UNIV AMER,DEPT ELECT ENGN,WASHINGTON,DC 20064, USA. NR 23 TC 32 Z9 33 U1 1 U2 2 PU TAYLOR & FRANCIS LTD PI LONDON PA ONE GUNDPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 0950-0340 J9 J MOD OPTIC JI J. Mod. Opt. PD JUL PY 1996 VL 43 IS 7 BP 1309 EP 1321 DI 10.1080/095003496155201 PG 13 WC Optics SC Optics GA UY737 UT WOS:A1996UY73700002 ER PT J AU Frank, JD Frank, JB AF Frank, JD Frank, JB TI Demoralization and unexplained illness in two cohorts of American soldiers overseas SO JOURNAL OF NERVOUS AND MENTAL DISEASE LA English DT Article C1 JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT,BALTIMORE,MD 21205. USA,MED CORPS,WASHINGTON,DC 20310. GEORGE WASHINGTON UNIV,SCH MED,WASHINGTON,DC. RI Dopko, Rae/J-7437-2015 NR 7 TC 5 Z9 5 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3018 J9 J NERV MENT DIS JI J. Nerv. Ment. Dis. PD JUL PY 1996 VL 184 IS 7 BP 445 EP 446 DI 10.1097/00005053-199607000-00012 PG 2 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA UY953 UT WOS:A1996UY95300012 PM 8691202 ER PT J AU Nichols, DD Bottini, AG AF Nichols, DD Bottini, AG TI Aplasia cutis congenita - Case report SO JOURNAL OF NEUROSURGERY LA English DT Article DE aplasia cutis congenita; tissue expansion; cranioplasty ID SKULL DEFECTS; SCALP AB The authors report the use of intraoperative tissue expansion in the treatment of a neonate with aplasia cutis congenita, a congenital defect of the scalp and skull. The case for immediate surgical intervention is presented, and intraoperative tissue expansion and cranioplasty are recommended as components of an effective surgical approach. C1 TRIPLER ARMY MED CTR,NEUROSURG SERV,HONOLULU,HI 96859. RP Nichols, DD (reprint author), TRIPLER ARMY MED CTR,GEN SURG SERV,1 JARRETT WHITE RD,HONOLULU,HI 96859, USA. NR 42 TC 17 Z9 17 U1 0 U2 0 PU AMER ASSOC NEUROLOGICAL SURGEONS PI CHARLOTTESVILLE PA UNIV VIRGINIA, 1224 WEST MAIN ST, STE 450, CHARLOTTESVILLE, VA 22903 SN 0022-3085 J9 J NEUROSURG JI J. Neurosurg. PD JUL PY 1996 VL 85 IS 1 BP 170 EP 173 DI 10.3171/jns.1996.85.1.0170 PG 4 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA UT668 UT WOS:A1996UT66800026 PM 8683269 ER PT J AU Degnan, BM McClellan, DR Francis, GL AF Degnan, BM McClellan, DR Francis, GL TI An analysis of fine-needle aspiration biopsy of the thyroid in children and adolescents SO JOURNAL OF PEDIATRIC SURGERY LA English DT Article DE biopsy; fine-needle; thyroid ID SUPPRESSIVE THERAPY; NODULES; MANAGEMENT; LEVOTHYROXINE; DISEASE AB Fine-needle aspiration biopsy (FNAB) has proven safe and efficacious in the evaluation nodular thyroid disease in adults. Only one study has evaluated FNAB exclusively in children, for whom the prevalence of thyroid nodules and the probability of malignancy are different. In addition. no study has compared the accuracy of FNAB with that of other diagnostic procedures in the evaluation of thyroid nodules in children. The authors report the results of FNAB in 18 children evaluated for thyroid nodules between 1985 and 1994. The overall accuracy of FNAB was similar to that of other diagnostic procedures, including thyroid scintiscan and ultrasonography, but none of these was sufficiently accurate to be used as the sole predictor of malignancy. There were three false-negative biopsy results; this limited the overall accuracy and suggests that children with negative FNAB results should be monitored cautiously. C1 UNIFORMED SERV UNIV HLTH SCI, DEPT PEDIAT, F EDWARD HEBERT SCH MED, BETHESDA, MD 20814 USA. WALTER REED ARMY MED CTR, DEPT PEDIAT, WASHINGTON, DC 20307 USA. NR 20 TC 26 Z9 28 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0022-3468 EI 1531-5037 J9 J PEDIATR SURG JI J. Pediatr. Surg. PD JUL PY 1996 VL 31 IS 7 BP 903 EP 907 DI 10.1016/S0022-3468(96)90407-8 PG 5 WC Pediatrics; Surgery SC Pediatrics; Surgery GA UV707 UT WOS:A1996UV70700008 PM 8811553 ER PT J AU Leo, KU Wesche, DL Marino, MT Brewer, TG AF Leo, KU Wesche, DL Marino, MT Brewer, TG TI Mefloquine effect on disposition of halofantrine in the isolated perfused rat liver SO JOURNAL OF PHARMACY AND PHARMACOLOGY LA English DT Article ID CLINICAL PHARMACOKINETICS; ANTIMALARIAL-DRUGS; MALARIA; METABOLISM; MICROSOMES AB Halofantrine and mefloquine are antimalarial drugs used in the treatment of malaria, including that caused by chloroquine-resistant Plasmodium falciparum. Reports of drug-associated adverse reactions, including sudden death in one patient, have prompted concerns over the safety of halofantrine and the potential for drug-drug interactions. We used the isolated perfused rat liver (IRL) model to investigate a possible hepatic metabolic or pharmacokinetic drug-drug interaction between halofantrine and mefloquine. Pharmacokinetic parameter estimates for halofantrine in the IPRL, reflected the pattern seen in in-vivo studies with doses comparable with clinical doses. Halofantrine parameter estimates (mean +/- s.d.) were: volume of distribution (Vd), 7.53 +/- 1.45 mL (g liver)(-1) clearance (CL), 0.11 +/- 0.07 mL. min(-1) (g liver)(-1) initial distribution half-life (initial t1/2), 14.62 +/- 2.38 min, terminal half-life (terminal t1/2), 138.7 +/- 178.8 min; AUC 606 +/- 194 mg mL(-1) min(-1) (g liver)(-1) elimination rate constant (K-e), 0.0135 +/- 0.012 min(-1). Prior dosing with mefloquine did not affect halofantrine perfusate pharmacokinetic parameter estimates of Vd, K-e, initial and terminal t1/2 (P > 0.05). A Single dose, short term (4-6 h) interaction showed significant changes in the perfusate clearance of halofantrine in mefloquine-pretreated livers using higher doses of halofantrine. Substantial changes were seen in bile production (P < 0.05) and biliary clearance (P < 0.05) of halofantrine in mefloquine-pretreated livers. These findings may have clinical implications in models utilizing multiple drug dosages or in patients with severe malaria who have disease-related cholestasis. RP Leo, KU (reprint author), WALTER REED ARMY INST RES,DIV EXPT THERAPEUT,WASHINGTON,DC 20307, USA. NR 25 TC 8 Z9 8 U1 0 U2 0 PU ROYAL PHARMACEUTICAL SOC GREAT BRITAIN PI LONDON PA 1 LAMBETH HIGH ST, LONDON, ENGLAND SE1 7JN SN 0022-3573 J9 J PHARM PHARMACOL JI J. Pharm. Pharmacol. PD JUL PY 1996 VL 48 IS 7 BP 723 EP 728 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA VD874 UT WOS:A1996VD87400013 PM 8866337 ER PT J AU Walmann, JO Donnelly, JC AF Walmann, JO Donnelly, JC TI Effect of dowel lubrication on resistance to dislodgment of dowels cemented with a 4-META resinous cement SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID RETENTION; TENSILE; POSTS AB Dentatus stainless steel dowels were cemented 5 mm into prepared canals of extracted human teeth with C&B Metabond cement. One half the dowels were lubricated before cementation to ensure easy subsequent retrieval. Significantly less tensile force was required to dislodge the lubricated dowels (p = 0.0209). Retrievable lubricated dowels could provide dentists the option of nonsurgical endodontic retreatment in lieu of endodontic surgery. However, lubrication cannot be recommended for clinical use at this time because of the potential for the dowel to unscrew during normal oral function. Further studies are required to determine the effects of rotational forces on the lubricated dowel, surface design of the dowel on retention, and chemical interaction of the lubricant on the resinous cement. Long-term effects of the lubricant on the cement are unknown. C1 USA,DENT ACTIV,FT HOOD,TX. NR 12 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD JUL PY 1996 VL 76 IS 1 BP 15 EP 18 DI 10.1016/S0022-3913(96)90339-X PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA UW220 UT WOS:A1996UW22000004 PM 8814628 ER PT J AU Ramos, V Runyan, DA Christensen, LC AF Ramos, V Runyan, DA Christensen, LC TI The effect of plasma-treated polyethylene fiber on the fracture strength of polymethyl methacrylate SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID PHYSICAL-PROPERTIES; ACRYLIC RESIN; REINFORCEMENT AB The effect of a plasma-treated polyethylene fiber on the fracture strength of polymethyl methacrylate was evaluated in this study. Sixteen treated and 16 untreated polymethyl methacrylate bars were tested by use of a three-point compression loading apparatus, Under the conditions of this experiment the treated bars showed a mean fracture strength of 12.56 MPa compared with 9.81 MPa for the untreated samples. In addition to the increased fracture strength, the treated bars also demonstrated resistance to crack propagation. The bars remained in one piece, held together throughout the compression loading by the polyethylene fiber. The clinical implication of these findings is a reduced incidence of fixed provisional restoration failure. C1 DWIGHT D EISENHOWER ARMY MED CTR,DEPT CLIN INVEST,EAMC,DENT CORPS,FT GORDON,GA 30905. USA,DENT ACTIV,WALTER REED ARMY MED CTR,ADV EDUC PROGRAM PROSTHODONT,DENT CORPS,WASHINGTON,DC 20310. NR 13 TC 54 Z9 55 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD JUL PY 1996 VL 76 IS 1 BP 94 EP 96 DI 10.1016/S0022-3913(96)90348-0 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA UW220 UT WOS:A1996UW22000013 PM 8814637 ER PT J AU Tischler, MB Williams, JN Ham, JA AF Tischler, MB Williams, JN Ham, JA TI The new ADS-33 process: Cautions for implementation - Comment SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article C1 USA,AVIAT TECH TEST CTR,AIRWORTHINESS QUALIFICAT TEST DIRECTORATE,EDWARDS AFB,CA. USA,AVIAT RES DEV & ENGN CTR,AEROFLIGHTDYNAM DIRECTORATE,AMES RES CTR,WASHINGTON,DC 20310. NR 17 TC 0 Z9 0 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JUL PY 1996 VL 41 IS 3 BP 194 EP 195 PG 2 WC Engineering, Aerospace SC Engineering GA VA268 UT WOS:A1996VA26800002 ER PT J AU Sherman, RA AF Sherman, RA TI Shock-absorbing orthotic inserts - Reply SO JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION LA English DT Letter RP Sherman, RA (reprint author), USA,MADIGAN ARMY MED CTR,TACOMA,WA 98431, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER PODIATRIC MED ASSN PI BETHESDA PA 9312 OLD GEORGETOWN ROAD, BETHESDA, MD 20814-1621 SN 0003-0538 J9 J AM PODIAT MED ASSN JI J. Am. Podiatr. Med. Assoc. PD JUL PY 1996 VL 86 IS 7 BP 351 EP 351 PG 1 WC Orthopedics SC Orthopedics GA UY670 UT WOS:A1996UY67000013 ER PT J AU Vorontsov, MA Carhart, GW Pruidze, DV Ricklin, JC Voelz, DG AF Vorontsov, MA Carhart, GW Pruidze, DV Ricklin, JC Voelz, DG TI Image quality criteria for an adaptive imaging system based on statistical analysis of the speckle field SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID PHASE-RETRIEVAL; TELESCOPE AB We introduce image quality criteria for organizing feedback control in adaptive imaging systems. These image quality criteria are dependent on the Fourier spectrum of the image and can be obtained optically with a coherent optical system. Digital processing of the image plane intensity distribution is not required. We present experimental results, along with corresponding numerical simulations, that demonstrate the potential effectiveness of these criteria for adaptive correction of phase-distorted extended-source images. (C) 1996 Optical Society of America C1 NEW MEXICO STATE UNIV,DEPT MECH ENGN,LAS CRUCES,NM 88003. USAF,PHILLIPS LAB,IMAGING BRANCH,KIRTLAND AFB,NM 87117. RP Vorontsov, MA (reprint author), USA,RES LAB,BATTLEFIELD ENVIRONM DIRECTORATE,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 26 TC 36 Z9 38 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0740-3232 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD JUL PY 1996 VL 13 IS 7 BP 1456 EP 1466 DI 10.1364/JOSAA.13.001456 PG 11 WC Optics SC Optics GA UU124 UT WOS:A1996UU12400017 ER PT J AU Gilmore, DL AF Gilmore, DL TI Total war on the Missouri border SO JOURNAL OF THE WEST LA English DT Article C1 US ARMY COMMAND & GEN STAFF COLL PRES,FT LEAVENWORTH,KS. RP Gilmore, DL (reprint author), COMBAT STUDIES INST,FT LEAVENWORTH,KS 66027, USA. NR 31 TC 3 Z9 3 U1 0 U2 0 PU J WEST INC PI MANHATTAN PA P O BOX 1009 1531 YUMA, MANHATTAN, KS 66502 SN 0022-5169 J9 J WEST JI J. West PD JUL PY 1996 VL 35 IS 3 BP 70 EP 80 PG 11 WC History SC History GA UW197 UT WOS:A1996UW19700010 ER PT J AU Napoli, PJ Meade, PC Adams, CW AF Napoli, PJ Meade, PC Adams, CW TI Primary aortoenteric fistula from a posttraumatic pseudoaneurysm SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article ID PRIMARY AORTODUODENAL FISTULA; ENTERIC FISTULAS; DIAGNOSIS; MANAGEMENT C1 SYRACUSE COLON & RECTAL SURG, SYRACUSE, NY USA. HONOLULU MED GRP, HONOLULU, HI USA. RP Napoli, PJ (reprint author), BROOKE ARMY MED CTR, CARDIOTHORAC SURG SERV, FT SAM HOUSTON, TX 78234 USA. NR 25 TC 8 Z9 8 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 EI 1529-8809 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 1996 VL 41 IS 1 BP 149 EP 152 DI 10.1097/00005373-199607000-00026 PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA UX857 UT WOS:A1996UX85700031 PM 8676410 ER PT J AU ManiscalcoTheberge, ME AF ManiscalcoTheberge, ME TI Untitled - Reply SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Letter RP ManiscalcoTheberge, ME (reprint author), WALTER REED ARMY MED CTR,GEN SURG SERV,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 1996 VL 41 IS 1 BP 170 EP 171 DI 10.1097/00005373-199607000-00033 PG 2 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA UX857 UT WOS:A1996UX85700038 ER PT J AU Garrick, J AF Garrick, J TI Farewell, darkness - Zaczek,R SO JOURNAL OF TRAUMATIC STRESS LA English DT Book Review RP Garrick, J (reprint author), WALTER REED ARMY MED CTR,BETHESDA,MD, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0894-9867 J9 J TRAUMA STRESS JI J. Trauma Stress PD JUL PY 1996 VL 9 IS 3 BP 663 EP 664 DI 10.1002/jts.2490090326 PG 2 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA UW921 UT WOS:A1996UW92100025 ER PT J AU Heshmat, H Brewe, DE AF Heshmat, H Brewe, DE TI Performance of a powder lubricated journal bearing with WS2 powder: Experimental study SO JOURNAL OF TRIBOLOGY-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT STLE/ASME Tribology Conference CY OCT 08-11, 1995 CL ORLANDO, FL SP STLE, ASME ID QUASI-HYDRODYNAMIC MECHANISM AB Previous investigations have demonstrated the principle and feasibility of quasi-hydrodynamic lubrication using powders. With conventional lubricants, the hydrodynamic behavior of a journal bearing can be summarized in the form of a plot of friction coefficient against a nondimensional load parameter usually referred to as a Stribeck curve. One of the main features of the curve is that, as the thickness of the lubricant film increases, the friction coefficient initially decreases until it reaches a minimum and then increases due to shearing of the lubricant film. Previous tests on a three pad journal bearing using molybdenum disulfide powder ns the lubricant showed that its friction/load characteristics followed the Stribeck form. The experimental work reported herein describes further tests carried out on a three-pad journal bearing to evaluate its thermal stability and long teem went characteristics using tungsten disulfide powder as the lubricant. Dry tungsten disulfide powder lubricant has been shown to provide excellent wear resistance. Its friction properties are similar to molybdenum disulfide but it can be used at much higher temperatures. Bearing tests were carried out nt speeds up to 30,000 rpm and lends Lip to 236 N. Over the load/speed, range stable thermal operation was achieved From friction torque measurements it was found that the coefficient of friction for the bearing was essentially constant over the range of lends and speeds. Unlike liquids, powders have a limiting shear strength property. When the limiting shear stress is reached in a powder flow, the powder essentially shears along a plane and does not pow in a viscous manner. The constant friction coefficient seen with the tungsten disulfide powder suggests that the powder had a low limiting shear strength and that this dominated the operation of the bearing in the rests. The total accumulated test time was more than eighteen hours. Periodically, the test journal and bearing pads were inspected but there was no measurable wear or visible damage. C1 USA,VEHICLE PROP DIRECTORATE,CLEVELAND,OH 44135. RP Heshmat, H (reprint author), MOHAWK INNOVAT TECHNOL INC,1059 BELRIDGE RD,NISKAYUNA,NY 12309, USA. NR 9 TC 17 Z9 20 U1 0 U2 11 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0742-4787 J9 J TRIBOL-T ASME JI J. Tribol.-Trans. ASME PD JUL PY 1996 VL 118 IS 3 BP 484 EP 491 DI 10.1115/1.2831563 PG 8 WC Engineering, Mechanical SC Engineering GA UX811 UT WOS:A1996UX81100007 ER PT J AU Giel, PW Sirbaugh, JR Lopez, I VanFossen, GJ AF Giel, PW Sirbaugh, JR Lopez, I VanFossen, GJ TI Three-dimensional Navier-Stokes analysis and redesign of an imbedded bellmouth nozzle in a turbine cascade inlet section SO JOURNAL OF TURBOMACHINERY-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT 39th International Gas Turbine and Aeroengine Congress and Exposition CY JUN 13-16, 1994 CL THE HAGUE, NETHERLANDS AB Experimental measurements in the inlet of a transonic turbine blade cascade showed unacceptable pitchwise flow nonuniformity. A three-dimensional, Navier-Stokes computational fluid dynamics (CFD) analysis of the imbedded bellmouth inlet in the facility was performed to identify and eliminate the source of the flow nonuniformity. The blockage and acceleration effects of the blades were accounted for by specifying a periodic static pressure exit condition interpolated from a separate three-dimensional Navier-Stokes CFD solution of flow around a single blade in an infinite cascade. Calculations of the original inlet geometry showed total pressure loss regions consistent in strength and location to experimental measurements. The results indicate that the distortions were caused by a pair of streamwise vortices that originated as a result of the interaction of the flow with the imbedded bellmouth. Computations were performed for an inlet geometry that eliminated the imbedded bellmouth by bridging the region between it and the upstream wall. This analysis indicated that eliminating the imbedded bellmouth nozzle also eliminates the pair of vortices, resulting in a flow with much greater pitchwise uniformity. Measurements taken with an installed redesigned inlet verify that the flow nonuniformity has indeed been eliminated. C1 USA,RES LAB,VEHICLE PROPULS DIRECTORATE,LEWIS RES CTR,CLEVELAND,OH 44135. NASA,LEWIS RES CTR,DIV INTERNAL FLUID MECH,CLEVELAND,OH 44135. RP Giel, PW (reprint author), NYMA INC,NASA,LEWIS RES CTR,BROOKPARK,OH 44142, USA. NR 15 TC 3 Z9 3 U1 0 U2 1 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0889-504X J9 J TURBOMACH JI J. Turbomach.-Trans. ASME PD JUL PY 1996 VL 118 IS 3 BP 529 EP 535 PG 7 WC Engineering, Mechanical SC Engineering GA UY735 UT WOS:A1996UY73500017 ER PT J AU Bettencourt, MCD Costabile, RA AF Bettencourt, MCD Costabile, RA TI Penile denudation after adult circumcision SO JOURNAL OF UROLOGY LA English DT Article DE penis; circumcision; surgical flaps; grafting, skin ID SKIN C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. RP Bettencourt, MCD (reprint author), WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307, USA. NR 8 TC 5 Z9 5 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD JUL PY 1996 VL 156 IS 1 BP 177 EP 178 DI 10.1016/S0022-5347(01)65983-4 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA UQ317 UT WOS:A1996UQ31700060 PM 8648789 ER PT J AU Waguespack, RL Fair, KP Svetec, DA Rozanski, TA AF Waguespack, RL Fair, KP Svetec, DA Rozanski, TA TI Glomangioma of the penile and scrotal median raphe SO JOURNAL OF UROLOGY LA English DT Article DE penis; glomangioma C1 BROOKE ARMY MED CTR,DEPT PATHOL,FT SAM HOUSTON,TX 78234. RP Waguespack, RL (reprint author), BROOKE ARMY MED CTR,DEPT UROL,FT SAM HOUSTON,TX 78234, USA. NR 3 TC 4 Z9 4 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD JUL PY 1996 VL 156 IS 1 BP 179 EP 179 DI 10.1016/S0022-5347(01)65984-6 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA UQ317 UT WOS:A1996UQ31700061 PM 8648790 ER PT J AU Mihailovich, RE Koscica, T Zeto, RJ AF Mihailovich, RE Koscica, T Zeto, RJ TI Measurement of the elastic stress of thin films deposited on gallium arsenide SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A-VACUUM SURFACES AND FILMS LA English DT Article ID GAAS AB We have measured the elastic stress of thin films of interest in GaAs microdevice processing, particularly for GaAs micromechanical structure fabrication. Stress was determined for films deposited directly on GaAs, in contrast to previous studies examining depositions on other substrates. Stress values were evaluated from the deflection of micron-thick GaAs cantilevers. Films examined include evaporated metals, chemical-vapor-deposition silicon nitride, and sputtered indium tin oxide. Stress values obtained for our films on GaAs are compared to values for these films deposited on other substrates. RP Mihailovich, RE (reprint author), USA,RES LAB,AMSRL,PS,DA,FT MONMOUTH,NJ 07703, USA. NR 15 TC 3 Z9 3 U1 1 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0734-2101 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A-Vac. Surf. Films PD JUL-AUG PY 1996 VL 14 IS 4 BP 2483 EP 2487 DI 10.1116/1.580006 PG 5 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA VA964 UT WOS:A1996VA96400075 ER PT J AU Shrestha, BP Duckstein, L Stakhiv, EZ AF Shrestha, BP Duckstein, L Stakhiv, EZ TI Fuzzy rule-based modeling of reservoir operation SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT-ASCE LA English DT Article ID SUSTAINABLE DEVELOPMENT; MEMBERSHIP FUNCTIONS; STATISTICAL-DATA AB A fuzzy rule-based model is constructed to derive operation rules for a multipurpose reservoir. The case study of the Tenkiller Lake in Oklahoma illustrates the methodology. Operation rules are generated on the basis of economic development criteria such as hydropower; municipal; industrial and irrigation demands; flood control and navigation; and environmental criteria such as water quality for fish and wildlife preservation, recreational needs, and downstream how regulation. The fuzzy rule-based model operates on an ''if-then'' principle, where the ''if'' is a vector of fuzzy explanatory variables or premises and ''then,'' of fuzzy consequences. The reservoir storage level, estimated inflows, and demands are used as the premises and release from the reservoir is taken as the consequence. Split sampling of historical data (mean daily time series of flow, lake level, demands, and releases) is used to train and then validate the rules. Different performance indices are calculated and two figures of merit, namely, engineering sustainability and engineering risk are developed for evaluating the rules generated by the model, which appears to be easy to construct, apply, and extend to a complex system of reservoirs. C1 UNIV ARIZONA,DEPT SYST & IND ENGN,TUCSON,AZ 85721. USA,IWR,POLICY & SPEC STUDIES DIV,CORPS ENGINEERS,FT BELVOIR,VA 22060. RP Shrestha, BP (reprint author), CORNELL UNIV,SCH CIVIL & ENVIRONM ENGN,HOLLISTER HALL,ITHACA,NY 14853, USA. NR 28 TC 99 Z9 100 U1 4 U2 19 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9496 J9 J WATER RES PL-ASCE JI J. Water Resour. Plan. Manage.-ASCE PD JUL-AUG PY 1996 VL 122 IS 4 BP 262 EP 269 DI 10.1061/(ASCE)0733-9496(1996)122:4(262) PG 8 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA UT007 UT WOS:A1996UT00700004 ER EF