FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Clough, RB Shapiro, AJ Bayba, AJ Lucey, GK AF Clough, Roger B. Shapiro, Alexander J. Bayba, Andrew J. Lucey, George K., Jr. TI Boundary Layer Fracture in Composite Solder Joints SO JOURNAL OF ELECTRONIC PACKAGING LA English DT Article AB Composite solder connections, modeled as miniature single-lap shear layers between copper plates, were fabricated and pulled to fracture. The solder layers (3.1 x 3.1 x 0.50 mm) were eutectic lead-tin/particulate Cu6Sn5 composites. Under load, shear fractures extended along paths about 10 mu m inside of the interfaces from opposite edges. These boundary layer fractures were characterized and a fracture model was developed. A corresponding test method for measuring J(II) and delta(II), the crack extension energy and crack tip shear displacement for Mode II crack growth, is given, and the results are discussed. Composite strengthening is shown to significantly improve the ductility and the creep life, properties associated with improved reliability and creep-fatigue life. C1 [Clough, Roger B.; Shapiro, Alexander J.] Natl Inst Stand & Technol, Gaithersburg, MD 20899 USA. [Bayba, Andrew J.; Lucey, George K., Jr.] US Army, Res Lab, Adelphi, MD 20783 USA. RP Clough, RB (reprint author), Natl Inst Stand & Technol, Gaithersburg, MD 20899 USA. FU Army Research Laboratory, Adelphi, MD FX This study was supported by the Army Research Laboratory, Adelphi, MD. We are indebted to Roland de Wit for helpful discussions on fracture mechanics. We also appreciate the technical assistance of Leonard Smith and David Pitchure. NR 19 TC 1 Z9 1 U1 1 U2 2 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 1043-7398 EI 1528-9044 J9 J ELECTRON PACKAGING JI J. Electron. Packag. PD DEC PY 1995 VL 117 IS 4 BP 270 EP 274 DI 10.1115/1.2792104 PG 5 WC Engineering, Electrical & Electronic; Engineering, Mechanical SC Engineering GA V41WY UT WOS:000209577500003 ER PT J AU DAMARLA, TR STROUD, CE SATHAYE, A AF DAMARLA, TR STROUD, CE SATHAYE, A TI MULTIPLE ERROR-DETECTION AND IDENTIFICATION VIA SIGNATURE ANALYSIS SO JOURNAL OF ELECTRONIC TESTING-THEORY AND APPLICATIONS LA English DT Article DE DIAGNOSTIC ALIASING; ERROR CORRECTING CODES; ERROR IDENTIFICATION; SIGNATURE ALIASING; SIGNATURE ANALYSIS AB Signature analysis has been used widely for fault detection as a part of Built-In Self Test (BIST). In this paper we show how signature analysis can be used not only for fault detection but also for identification of multiple errors produced by faults in the circuits under test. We construct Signature Analysis Registers (SARs) to detect and identify any specified number of errors in the input polynomials by choosing proper characteristic polynomials, To detect and identify r errors in an input bit stream of m bits, we use a polynomial g(r)(x) = 1cm (f(1)(x), f(3)(x),...,f(2r-1)(x)) as the characteristic polynomial for the SAR for any polynomial f(1)(x), where 1cm represents the least common multiple of polynomials f(i)(x) = Res(t)(f(1)(t), x-t(i)), i = 3,...,2r-1 Res(t) denotes the t-Resultant, and m is less than the order of f(1)(x). Given a faulty signature produced by an SAR constructed as described, we present an algorithm for the identification of the actual error bits in the input polynomial to the SAR. We also extend the use of BCH codes for error detection and correction to include nonprimitive polynomials. C1 UNIV KENTUCKY,DEPT ELECT ENGN,LEXINGTON,KY 40506. UNIV KENTUCKY,DEPT MATH,LEXINGTON,KY 40506. RP DAMARLA, TR (reprint author), USA,RES LABS,EA,PS,AMSRL,NATL RES COUNCIL,FT MONMOUTH,NJ 07703, USA. NR 21 TC 26 Z9 26 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0923-8174 J9 J ELECTRON TEST JI J. Electron. Test.-Theory Appl. PD DEC PY 1995 VL 7 IS 3 BP 193 EP 207 DI 10.1007/BF00995313 PG 15 WC Engineering, Electrical & Electronic SC Engineering GA TG707 UT WOS:A1995TG70700005 ER PT J AU Veloso, D Denny, S Cosgriff, TM Hochstein, HD AF Veloso, D Denny, S Cosgriff, TM Hochstein, HD TI Differential susceptibility of rhesus monkeys to high doses of endotoxin SO JOURNAL OF ENDOTOXIN RESEARCH LA English DT Article ID TUMOR-NECROSIS-FACTOR; HUMAN SEPTIC SHOCK; ESCHERICHIA-COLI; MONOCLONAL-ANTIBODY; LETHAL BACTEREMIA; TISSUE-INJURY; INTERLEUKIN-1; CACHECTIN; PLASMA; LIPOPOLYSACCHARIDE AB We investigated susceptibility of rhesus monkeys (Macaca mulatta) to Escherichia coli endotoxin (ETX) in two ways, We infused 8 monkeys (group A) with various doses of ETX (1.0-7.5 mg/kg) to assess the effect of dose on shock severity; and we infused 6 monkeys (group B) with 1.0 mg ETX/kg to test biological variability to ETX challenge, Controls were 7 saline-infused monkeys, Systolic pressure, heart rate (HR), temperature, plasma ETX and inflammatory markers - tumor necrosis factor-alpha (TNF), interleukin-1 (IL-1) and IL-6 - were quantified before and at 1.5, 2.5, 6 and 26 h after infusion, The highest plasma concentrations of ETX (at 1.5 h) - < 8% that infused - correlated well with the infused doses, ETX elicited hypotension and increases in HR in all monkeys, Fever did not occur, The degree of hypotension and increase in HR and death did not correlate with ETX dose (or plasma ETX concentrations). The response of inflammatory cytokines to ETX was greater in nonsurvivors than in survivors, The observed low mortality rate (4/14) suggests that rhesus monkeys are rather resistant to high endotoxin concentrations similar to baboons but unlike humans or chimpanzees, The lack of correlation between ETX dose and shock severity suggests that there is a critical ETX concentration in each animal that leads to controllable or uncontrollable cytokine elevation in plasma, with reversible or irreversible shock, and resulting survival or death. C1 UNIV TEXAS, HLTH SCI CTR, DEPT PSYCHIAT & BEHAV SCI, HOUSTON, TX 77030 USA. USA, MED RES INST INFECT DIS, ANIM RESOURCES DIV, FT DETRICK, MD 21702 USA. JEFFERSON ONCOL CLIN, METAIRIE, LA 70006 USA. US FDA, CTR BIOL EVALUAT & RES, BETHESDA, MD 20852 USA. USA, MED RES INST INFECT DIS, DIV MED, FREDERICK, MD 21702 USA. USA, MED RES INST INFECT DIS, DIV MED, FT DETRICK, MD 21702 USA. NR 56 TC 2 Z9 2 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0968-0519 J9 J ENDOTOXIN RES JI J. Endoxtin Res. PD DEC PY 1995 VL 2 IS 6 BP 411 EP 420 PG 10 WC Biochemistry & Molecular Biology; Immunology; Medicine, Research & Experimental; Microbiology SC Biochemistry & Molecular Biology; Immunology; Research & Experimental Medicine; Microbiology GA TP938 UT WOS:A1995TP93800004 ER PT J AU CHU, YK JENNINGS, G SCHMALJOHN, A ELGH, F HJELLE, B LEE, HW JENISON, S KSIAZEK, T PETERS, CJ ROLLIN, P SCHMALJOHN, C AF CHU, YK JENNINGS, G SCHMALJOHN, A ELGH, F HJELLE, B LEE, HW JENISON, S KSIAZEK, T PETERS, CJ ROLLIN, P SCHMALJOHN, C TI CROSS-NEUTRALIZATION OF HANTAVIRUSES WITH IMMUNE SERA FROM EXPERIMENTALLY INFECTED ANIMALS AND FROM HEMORRHAGIC-FEVER WITH RENAL SYNDROME AND HANTAVIRUS PULMONARY SYNDROME PATIENTS SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note ID HANTAAN AB Plaque-reduction neutralization tests were done with eight of nine known representative hantaviruses and immune sera from experimentally infected animals and from patients with hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS), Results obtained with animal sera demonstrated each virus to be antigenically unique, Neutralization with the HPS patient sera was highest with Sin Nombre (SN) virus and to a lesser extent with Black Creek Canal (BCC) virus, Sera from Korean HFRS patients reacted best with Hantaan virus, but cross-reactivity with all other viruses except Thottapalayam (TPM) virus was also observed. Sera from Swedish HFRS patients reacted best with Puumala virus but cross-reacted with Prospect Hill, SN, and BCC viruses and to a lesser extent with all of the other viruses except TPM virus. C1 USA, MED RES INST INFECT DIS, DIV VIROL, FREDERICK, MD 21702 USA. UMEA UNIV, DEPT VIROL, UMEA, SWEDEN. UNIV NEW MEXICO, DEPT PATHOL, ALBUQUERQUE, NM 87131 USA. UNIV NEW MEXICO, DEPT MED, ALBUQUERQUE, NM 87131 USA. ASAN INST LIFE SCI, SEOUL, SOUTH KOREA. CTR DIS CONTROL, SPECIAL PATHOGENS BRANCH, ATLANTA, GA 30333 USA. FU NIAID NIH HHS [AI-36336] NR 11 TC 42 Z9 44 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD DEC PY 1995 VL 172 IS 6 BP 1581 EP 1584 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA TF776 UT WOS:A1995TF77600023 PM 7594720 ER PT J AU MASCOLA, JR MCNEIL, JG AF MASCOLA, JR MCNEIL, JG TI HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 CANDIDATE VACCINE BREAKTHROUGH INFECTION SO JOURNAL OF INFECTIOUS DISEASES LA English DT Letter C1 USN,MED RES INST,DEPT INFECT DIS,BETHESDA,MD. RP MASCOLA, JR (reprint author), WALTER REED ARMY INST RES,DIV RETROVIROL,1600 E GUDE DR,ROCKVILLE,MD 20850, USA. NR 8 TC 1 Z9 1 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD DEC PY 1995 VL 172 IS 6 BP 1636 EP 1637 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA TF776 UT WOS:A1995TF77600040 PM 7594736 ER PT J AU Dhawan, S Wahl, LM Heredia, A Zhang, YH Epstein, JS Meltzer, MS Hewlett, IK AF Dhawan, S Wahl, LM Heredia, A Zhang, YH Epstein, JS Meltzer, MS Hewlett, IK TI Interferon-gamma inhibits HIV-induced invasiveness of monocytes SO JOURNAL OF LEUKOCYTE BIOLOGY LA English DT Article DE interferon-gamma; human immunodeficiency virus monocytes; metalloproteinase; extracellular matrix ID AIDS; COLLAGENASE AB HIV-infected monocytes form highly invasive network on basement membrane matrix and secrete high levels of 92-kd metalloproteinase (MMP-9), an enzyme that degrades basement membrane proteins. In the present study, using matrigel as a model basement membrane system, we demonstrate that treatment of human immunodeficiency virus (HIV)-infected monocytes with interferon-gamma at 50 U/ml inhibited the ability of infected monocytes to form an invasive network on matrigel and their invasion through the matrigel matrix. These effects were associated with a significant reduction in the levels of MMP-9 produced by HIV-infected monocytes treated with interferon-gamma 1 day prior to infection with HIV as compared with that of untreated HIV-infected monocytes. Monocytes treated with interferon-gamma 1 day after HIV infection showed the presence of integrated HIV sequences; however, the levels of MMP-9 were substantially lower than those produced by monocytes inoculated with live HIV, heat-inactivated HIV, or even the control uninfected monocytes. Exposure of monocytes to heat-inactivated HIV did not result in increased invasiveness or high MMP-9 production, suggesting that regulation of metalloproteinase by monocytes was independent of CD4-gp120 interactions and required active virus infection. Furthermore, addition of interferon-gamma to monocytes on day 10 after infection inhibited MMP-9 production by more than threefold with no significant reduction of virus replication. These results indicate that the mechanism of interferon-gamma-induced down-regulation of MMP-9 levels and reduced monocyte invasiveness may be mediated by a mechanism independent of antiviral activity of IFN-gamma in monocytes. Down-regulation of MMP-9 in HIV-infected monocytes by interferon-gamma may play an important role in the control of HIV pathogenesis. C1 NIDR,IMMUNOL LAB,BETHESDA,MD 20892. WALTER REED ARMY INST RES,DEPT CELLULAR IMMUNOL,WASHINGTON,DC. RP Dhawan, S (reprint author), US FDA,CTR BIOL EVALUAT & RES,DIV TRANSFUS TRANSMITTED DIS,MOLEC VIROL LAB,ROCKVILLE,MD 20852, USA. NR 11 TC 22 Z9 22 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0741-5400 J9 J LEUKOCYTE BIOL JI J. Leukoc. Biol. PD DEC PY 1995 VL 58 IS 6 BP 713 EP 716 PG 4 WC Cell Biology; Hematology; Immunology SC Cell Biology; Hematology; Immunology GA TK772 UT WOS:A1995TK77200012 PM 7499970 ER PT J AU Munavalli, S Jakubowski, EM Durst, HD AF Munavalli, S Jakubowski, EM Durst, HD TI Liquid chromatography thermospray mass spectrometry of mustard and its metabolites SO JOURNAL OF MASS SPECTROMETRY LA English DT Article ID CHEMICAL WARFARE AGENTS; IONIZATION; GAS; INTERFACE AB There is considerable interest in the detection and analysis of chemical warfare agents. Since thermospray provides soft ionization and interesting fragmentation patterns under discharge conditions, the liquid chromatographic/thermospray mass spectrometric behavior of bis(2-chloroethyl) sulfide and its metabolites was investigated, All of the metabolites except mustard sulfone and thiodiglycol sulfone indicated the presence of a three-membered cyclic sulfonium ion intermediate or its equivalent in their mass spectra, Other observed reactions of the above substrates include polymerizations and nucleophilic substitution reactions. C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. USA,EDGEWOOD CHEM RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. RP Munavalli, S (reprint author), GEOCENTERS INC,FT WASHINGTON,MD 20744, USA. NR 29 TC 13 Z9 14 U1 1 U2 5 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 1076-5174 J9 J MASS SPECTROM JI J. Mass Spectrom. PD DEC PY 1995 VL 30 IS 12 BP 1716 EP 1722 DI 10.1002/jms.1190301212 PG 7 WC Biophysics; Chemistry, Organic; Spectroscopy SC Biophysics; Chemistry; Spectroscopy GA TK616 UT WOS:A1995TK61600011 ER PT J AU Evans, MA AF Evans, MA TI Downsizing in the US Army: Common concerns of survivors SO JOURNAL OF POLITICAL & MILITARY SOCIOLOGY LA English DT Article AB This paper focuses on the common concerns of survivors of the curl ent military downsizing. To help place these concerns in context an overview of past demobilizations and the present military downsizing is presented. Officers and enlisted soldiers voiced their concerns about downsizing in semi-structured interviews. The common concerns include leader behavior, access to information, continued commitment, stress and family, satisfaction, readiness, and career intentions. RP Evans, MA (reprint author), USA,CTR HEALTHCARE EDUC & STUDIES,BAYLOR MASTERS HEALTHCARE ADM PROGRAM,FT SAM HOUSTON,TX, USA. NR 16 TC 2 Z9 2 U1 1 U2 5 PU JOURNAL POLITICAL MILITARY SOCIOLOGY PI DE KALB PA DEPT SOCIOLOGY, NORTHERN ILLINOIS UNIV, DE KALB, IL 60115-2854 SN 0047-2697 J9 J POLIT MIL SOCIOL JI J. Polit. Mil. Soc. PD WIN PY 1995 VL 23 IS 2 BP 271 EP 287 PG 17 WC Political Science; Sociology SC Government & Law; Sociology GA TZ880 UT WOS:A1995TZ88000006 ER PT J AU CHENG, YY CEBE, P CAPEL, M SCHREUDERGIBSON, H BLUHM, A YEOMANS, W AF CHENG, YY CEBE, P CAPEL, M SCHREUDERGIBSON, H BLUHM, A YEOMANS, W TI SMALL-ANGLE X-RAY-SCATTERING STUDY OF LIQUID-CRYSTALLINE POLYCARBONATES BASED ON ALPHA-METHYL STILBENE MESOGEN AND METHYLENE-CONTAINING FLEXIBLE SPACER SO JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS LA English DT Article DE SMALL-ANGLE X-RAY SCATTERING; MONOTROPIC LIQUID CRYSTALLINE POLYMER; STILBENE MESOGEN; METHYLENE SPACER; ODD-EVEN EFFECT ID ETHER KETONE) CRYSTALLIZATION; CONFORMATIONAL ISOMERISM; MAIN-CHAIN; THERMOTROPIC POLYETHERS; PHASE-TRANSITIONS; MELTING BEHAVIOR; THERMAL HISTORY; ODD NUMBER; 1-(4-HYDROXYPHENYL)-2-(2-METHYL-4-HYDROXYPHENYL)ETHANE; POLYMERS AB Crystallization and melting behavior are studied by small-angle X-ray scattering (SAXS) for a series of recently synthesized monotropic liquid crystalline polycarbonates based on alpha-methyl stilbene mesogen and methylene flexible spacer. The one-dimensional electron density correlation function is used to obtain long period, crystal thickness, and linear crystallinity from the Lorentz-corrected SAXS intensity. Changes in these parameters during nonisothermal crystallization and melting are explained by a model of dual crystal populations. The primary crystals form first using the liquid crystalline phase as crystal nuclei, while smaller and less perfect crystals form later from the isotropic phase at low temperature. The results of the real-time SAXS study of isothermal crystallization also support the view that: the nematic phase serves as crystal nuclei for fast crystallization. An odd-even effect in crystal thickness and linear crystallinity is observed in all the SAXS experiments mentioned above. The results of this study and our complementary wide-angle X-ray scattering (WAXS) investigation show clearly that the difference in the position of the neighboring carbonate dipoles on a chain affects structural organization both at the unit cell level and at the level of the crystal in these monotropic LCPs. (C) 1995 John Wiley & Sons, Inc. C1 MIT,DEPT MAT SCI & ENGN,CAMBRIDGE,MA 02139. BROOKHAVEN NATL LAB,DEPT BIOL,UPTON,NY 11973. USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. NR 45 TC 15 Z9 15 U1 1 U2 2 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0887-6266 J9 J POLYM SCI POL PHYS JI J. Polym. Sci. Pt. B-Polym. Phys. PD DEC PY 1995 VL 33 IS 17 BP 2331 EP 2341 DI 10.1002/polb.1995.090331704 PG 11 WC Polymer Science SC Polymer Science GA TG026 UT WOS:A1995TG02600004 ER PT J AU Rattanarithikul, R Green, CA Panyim, S Noigamol, C Chanaimongkol, S Mahapibul, P AF Rattanarithikul, R Green, CA Panyim, S Noigamol, C Chanaimongkol, S Mahapibul, P TI Larval habitats of malaria vectors and other Anopheles mosquitoes around a transmission focus in northwestern Thailand SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article AB We sampled 199 bodies of water for Anopheles larvae around a malaria-endemic village near Mae Sot, Thailand, over 2 years. Anopheles dirus species A and D occurred in 54 small, well-shaded, stream and temporary, ground pools. The larval habitat of species D is reported for the first time. Anopheles minimus species A occurred in 8 samples from slow-moving streams, in 8 from rice fields, and in 2 from ground pools. Anopheles pseudowillmori occurred in one sample from a ground pool, in 3 from streams, and in 9 from rice fields. C1 MRC,NATL MALARIA CONTORL PROGRAMME,CONGELLA 4013,SOUTH AFRICA. MAHIDOL UNIV,FAC SCI,DEPT BIOCHEM,BANGKOK 10400,THAILAND. RP Rattanarithikul, R (reprint author), ARMED FORCES RES INST MED SCI,USA MED COMPONENT,DEPT ENTOMOL,315-6 RAJVITHI RD,BANGKOK 10400,THAILAND. RI Panyim, Sakol/B-6024-2008 NR 9 TC 25 Z9 25 U1 0 U2 0 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 1995 VL 11 IS 4 BP 428 EP 433 PG 6 WC Entomology SC Entomology GA TN846 UT WOS:A1995TN84600008 PM 8825502 ER PT J AU Copeland, RS Walker, TW Robert, LL Githure, JI Wirtz, RA Klein, TA AF Copeland, RS Walker, TW Robert, LL Githure, JI Wirtz, RA Klein, TA TI Response of wild Anopheles funestus to repellent-protected volunteers is unaffected by malaria infection of the vector SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article ID PLASMODIUM-FALCIPARUM SPOROZOITE; FEEDING-BEHAVIOR; WESTERN KENYA; MOSQUITOS; TRANSMISSION; CULICIDAE; DIPTERA AB A field experiment was conducted to compare the biting behavior of Plasmodium falciparum-infected and uninfected Anopheles on humans using mosquito repellents. Repellent formulations (5% [wt/vol] N,N-diethyl-3-methylbenzamide [deet] or 5% [wt/vol] AI3-37220, a piperidine compound, both in 100% ethanol, or 100% ethanol alone [as a control]) were applied to the lower legs of 3 collectors in each of 4 houses. Collectors caught mosquitoes over 6 collection nights. Mosquitoes were collected into vials after they initiated probing on the leg of a collector. Infected females made up the same proportion of the Anopheles funestus populations biting either repellent-protected or unprotected individuals. We conclude that repellent formulations are equally effective against Plasmodium-infected and uninfected An. funestus. C1 KENYA GOVT MED RES CTR,NAIROBI,KENYA. WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. RP Copeland, RS (reprint author), USA,MED RES UNIT,BOX 401,APO,AE 09831, USA. NR 15 TC 7 Z9 7 U1 0 U2 1 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 1995 VL 11 IS 4 BP 438 EP 440 PG 3 WC Entomology SC Entomology GA TN846 UT WOS:A1995TN84600010 PM 8825504 ER PT J AU CLARK, JY THOMPSON, IM OPTENBERG, SA AF CLARK, JY THOMPSON, IM OPTENBERG, SA TI ECONOMIC-IMPACT OF UROLITHIASIS IN THE UNITED-STATES SO JOURNAL OF UROLOGY LA English DT Article DE COST CONTROL; URINARY CALCULI; LITHIASIS; HEALTH BENEFIT PLANS, EMPLOYEE; KIDNEY CALCULI ID FREQUENCY AB Purpose: We determined the economic costs to individuals in 1993 for the evaluation and treatment of upper urinary tract calculi. Materials and Methods: Hospital discharge statistics, prevalence data for urolithiasis and the relative frequency of surgical treatments from Civilian Health and Medical Program of the Uniformed Services claims data were assessed. Results: The total charges for evaluation, hospitalization and treatment were estimated to be $1.23 billion per year. Professional charges for those who were hospitalized were estimated to be $183 million. Outpatient evaluation of urolithiasis was expected to cost $278 million. Indirect costs for lost wages were estimated to be $139 million. Conclusions: The total annual cost for urolithiasis in the United States is estimated to be $1.83 billion. C1 BROOKE ARMY MED CTR,DEPT SURG,UROL SERV,SAN ANTONIO,TX 78234. HLTH SERV COMMAND,CLIN INVEST ACTIV,SAN ANTONIO,TX. OI Clark, Joseph/0000-0002-3817-4343 NR 27 TC 86 Z9 86 U1 0 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD DEC PY 1995 VL 154 IS 6 BP 2020 EP 2024 DI 10.1016/S0022-5347(01)66680-1 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA TD947 UT WOS:A1995TD94700012 PM 7500448 ER PT J AU Jackson, MR Olsen, SB Gomez, ER Alving, BM AF Jackson, MR Olsen, SB Gomez, ER Alving, BM TI Use of antithrombin III concentrates to correct antithrombin III deficiency during vascular surgery SO JOURNAL OF VASCULAR SURGERY LA English DT Note AB Congenital deficiency of antithrombin III (AT III) is the only inherited hypercoagulable disorder for which a concentrate of purified protein is available for replacement therapy during periods of increased thrombotic risk. This report describes how such concentrates have been used in a patient with congenital AT-III deficiency undergoing venous surgery. A 40-year-old woman with AT III deficiency was evaluated for bilateral grade 3 chronic venous insufficiency. Noninvasive venous assessment and ascending venography revealed incompetence of the lower leg perforators, a patent deep venous system, and competent greater and lesser saphenous veins. Staged subfascial ligations were performed. Pasteurized AT LII was administered 1 hour before surgery and at 30 hours at a dose calculated to increase AT-III activity to at least 120%. Perioperative AT III activity levels were measured. Subcutaneous heparin and oral warfarin were initiated the evening of surgery. An infusion of AT III increased plasma AT III from the baseline activity of 51% to 180%; it was 87% 13 hours later. Two measurements of the initial half-life of AT III were 7 and 14 hours. No perioperative thrombotic complications occurred. The ulcers healed, and the patient remains symptom free. Pasteurized AT III concentrates are now commercially available, easily administered, and provide a useful adjunct to the anticoagulation regimen of patients with AT III deficiency undergoing vascular surgery. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT HEMATOL & VASC BIOL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. RP Jackson, MR (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,PERIPHERAL VASC SURG SERV,WASHINGTON,DC 20307, USA. NR 12 TC 7 Z9 7 U1 0 U2 2 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD DEC PY 1995 VL 22 IS 6 BP 804 EP 807 DI 10.1016/S0741-5214(95)70072-2 PG 4 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA TK887 UT WOS:A1995TK88700021 PM 8523616 ER PT J AU Barth, J AF Barth, J TI The Beardstown ladies' stitch-in-time guide to growing your nest egg: Step-by-step planning for a comfortable financial future - Beardstown-Ladies-Invest-Club-Robin-Dellabough SO LIBRARY JOURNAL LA English DT Book Review RP Barth, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD DEC PY 1995 VL 120 IS 20 BP 120 EP 120 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA TK468 UT WOS:A1995TK46800143 ER PT J AU Muscato, JJ Cirrincione, C Clamon, G Perry, MC Omura, G Berkowitz, I Reid, T Herndon, JE Green, MR AF Muscato, JJ Cirrincione, C Clamon, G Perry, MC Omura, G Berkowitz, I Reid, T Herndon, JE Green, MR TI Etoposide (VP-16) and cisplatin at maximum tolerated dose in non-small cell lung carcinoma: A cancer and leukemia group B study SO LUNG CANCER LA English DT Article DE non-small cell lung cancer; chemotherapy; etoposide; cisplatin; dose intensity ID PHASE-II; CHEMOTHERAPY; INTENSITY AB A multi-institutional cooperative group trial was undertaken by the Cancer and Leukemia Group B (CALGB) to evaluate the efficacy of the combination of cisplatin and intravenous etoposide for the treatment of metastatic or recurrent non-small cell lung cancer (NSCLC), The doses used were those previously determined to be the maximally tolerated dose of this drug combination, Forty patients were entered into the trial, 37 of whom were eligible for evaluation, Cisplatin (35 mg/M2/day for 3 days) and etoposide (200 mg/M2/day for 3 days) were administered every 28 days for a planned 6 cycles of therapy, Sixteen of 37 evaluable patients (43%) responded to therapy, Myelosuppression was the dominant toxicity, with 89% of the patients experiencing grade 4 neutropenia, and nearly half grade 3 or 4 thrombocytopenia, Median survival was 8.5 months, with 30% of the patients alive at 1 year and 10% alive at 2 years. Malaise, fatigue, and peripheral neuropathy were the other major toxicities. The combination of etoposide at the dose of 200 mg/M2/day for 3 days and cisplatin at 35 mg/M2/day for 3 days is a highly potent combination against metastatic non-small cell carcinoma. C1 CANC & LEUKEMIA GRP B,STAT OFF,DURHAM,NC. UNIV IOWA,DEPT MED,IOWA CITY,IA 52242. UNIV MISSOURI,DEPT MED,COLUMBIA,MO. UNIV ALABAMA,DEPT MED,BIRMINGHAM,AL 35294. DELAWARE MED CTR,WILMINGTON,DE. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIV SAN DIEGO,SAN DIEGO,CA 92110. RP Muscato, JJ (reprint author), HEMATOL ONCOL ASSOCIATES,3401 BERRYWOOD DR,COLUMBIA,MO 65201, USA. FU NCI NIH HHS [CA 12046, CA 33601, CA 47642] NR 17 TC 5 Z9 5 U1 0 U2 0 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0169-5002 J9 LUNG CANCER-J IASLC JI Lung Cancer PD DEC PY 1995 VL 13 IS 3 BP 285 EP 294 DI 10.1016/0169-5002(95)00501-3 PG 10 WC Oncology; Respiratory System SC Oncology; Respiratory System GA TQ665 UT WOS:A1995TQ66500005 PM 8719068 ER PT J AU SCHNEIDER, DA KAMIMORI, GH WU, SY MCENIERY, MT SOLOMON, C AF SCHNEIDER, DA KAMIMORI, GH WU, SY MCENIERY, MT SOLOMON, C TI PLASMA-CATECHOLAMINE AND VENTILATORY RESPONSES TO CYCLING AFTER PROPRANOLOL TREATMENT SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE EPINEPHRINE; NOREPINEPHRINE; BETA-ADRENERGIC BLOCKADE; CONTROL OF VENTILATION; EXERCISE HYPERPNEA ID EXERCISE; POTASSIUM; CHEMORECEPTORS; HYPERTENSION; BLOCKADE; LACTATE; CAT AB The purpose of the present study was to examine the relationship between minute ventilation (V-E) and plasma concentrations of epinephrine (EPI) and norepinephrine (NE) during incremental cycling (20 W . 2 min(-1)) performed under conditions of beta-adrenergic blockade (80 mg of propranolol) and placebo in six untrained male subjects. No significant differences existed between treatments in O-2 uptake, CO2 output, blood lactate, pH, or V-E during the submaximal work stages of incremental exercise common to both treatments (20-220 W). During exercise with beta-blockade, EPI, and NE concentrations were both significantly elevated compared with control levels at every submaximal work stage. Significant positive correlations between V-E and plasma levels of EPI and NE were found during both beta-blockade (r = 0.98 and 1.00) and control conditions (r = 0.98 and 0.96). Although the high correlations were unchanged during exercise with beta-blockade, the slopes of the regression lines for the V-E-EPI and the V-E-NE relationships were both significantly reduced compared with control conditions. beta-blockade resulted in elevated plasma levels of both EPI and NE compared with control conditions without causing a change in exercise V-E. These findings suggest that catecholamines may not be important substances in regulating breathing during exercise. C1 WALTER REED ARMY INST RES,DEPT BEHAV BIOL,WASHINGTON,DC 20307. UNIV QUEENSLAND,ERGOMETRY LAB,BRISBANE,QLD 4072,AUSTRALIA. RP SCHNEIDER, DA (reprint author), NORTHEASTERN UNIV,DEPT CARDIOPULM SCI,HUMAN PERFORMANCE LAB,100 DOCKSER HALL,BOSTON,MA 02115, USA. NR 26 TC 10 Z9 10 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD DEC PY 1995 VL 27 IS 12 BP 1616 EP 1620 PG 5 WC Sport Sciences SC Sport Sciences GA TJ499 UT WOS:A1995TJ49900006 PM 8614316 ER PT J AU BRADY, BH AF BRADY, BH TI NOTICE PROVISIONS FOR UNITED-STATES CITIZEN CONTRACTORS EMPLOYEES SERVING WITH THE ARMED-FORCES OF THE UNITED-STATES IN THE FIELD - TIME TO REFLECT THEIR ASSIMILATED STATUS IN GOVERNMENT CONTRACTS SO MILITARY LAW REVIEW LA English DT Article AB Over the past two decades, the Armed Forces of the United States have reduced their combat service support capabilities. As a result, government contractors note perform military logistics functions in the field. Increasingly, commanders must plan for deployment of contractor employees in the field. Unfortunately few commanders and few contractors understand their rights and obligations. The author proposes to amend the Defense Federal Acquisition Regulation Supplement (DFARS) to give contractors notice of the rights and obligations of their employees in the field. The author's position. is that government contractor employees hold military status in the field. Therefore, the Armed Forces of the United States must accord contractor employees similar rights and privileges to those afforded to government employees and military personnel who deploy in support of a military mission. In this way, commanders will integrate civilian contractor employees into the total force projection team in the field. C1 USA,JUDGE ADVOCATE GEN CORPS,CHARLOTTESVILLE,VA 22903. NR 68 TC 4 Z9 4 U1 0 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 1995 VL 147 BP 1 EP 83 PG 83 WC Law SC Government & Law GA TG270 UT WOS:A1995TG27000001 ER PT J AU SHAVER, DP AF SHAVER, DP TI RESTORING THE PROMISE OF THE RIGHT TO SPEEDY TRIAL TO SERVICE MEMBERS IN PRETRIAL ARREST AND CONFINEMENT SO MILITARY LAW REVIEW LA English DT Article RP SHAVER, DP (reprint author), USA,JUDGE ADVOCATE GEN CORPS,SYST PERFORMANCE OFF,GEN COUNSEL,CHARLOTTESVILLE,VA 22903, USA. NR 16 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 1995 VL 147 BP 84 EP 144 PG 61 WC Law SC Government & Law GA TG270 UT WOS:A1995TG27000002 ER PT J AU DAVIDSON, MJ AF DAVIDSON, MJ TI A MODEST PROPOSAL - PERMIT INTERLOCUTORY APPEALS OF SUMMARY JUDGMENT DENIALS SO MILITARY LAW REVIEW LA English DT Article ID CIVIL PROCEDURE; FEDERAL-RULES; DECISIONS; COURTS RP DAVIDSON, MJ (reprint author), USA,JUDGE ADVOCATE GEN CORPS,ARMY PROCUREMENT FRAUD DIV,CHARLOTTESVILLE,VA 22903, USA. NR 71 TC 9 Z9 9 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 1995 VL 147 BP 145 EP 217 PG 73 WC Law SC Government & Law GA TG270 UT WOS:A1995TG27000003 ER PT J AU PENDOLINO, TJ AF PENDOLINO, TJ TI THE DAVIS-BACON AND SERVICE CONTRACT ACTS - LAWS WHOSE TIME HAS PASSED SO MILITARY LAW REVIEW LA English DT Article RP PENDOLINO, TJ (reprint author), USA,JUDGE ADVOCATE GEN CORPS,JUDGE ADVOCATE GEN SCH,DEPT CONTRACT LAW,CHARLOTTESVILLE,VA 22903, USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 1995 VL 147 BP 218 EP 261 PG 44 WC Law SC Government & Law GA TG270 UT WOS:A1995TG27000004 ER PT J AU CRANE, DM AF CRANE, DM TI THE BATTLE OF THE GENERALS - THE UNTOLD STORY OF THE FALAISE POCKET - BLUMENSON,M SO MILITARY LAW REVIEW LA English DT Book Review RP CRANE, DM (reprint author), USA,JUDGE ADVOCATE GEN SCH,DEPT INT & OPERAT LAW,CHARLOTTESVILLE,VA 22903, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 1995 VL 147 BP 289 EP 292 PG 4 WC Law SC Government & Law GA TG270 UT WOS:A1995TG27000006 ER PT J AU OHARE, PD AF OHARE, PD TI MILITARY EVIDENTIARY FOUNDATIONS - SCHLEUTER,DA, SALTZBURG,SA, SCHINASI,LD, IMWINKELRIED,EM SO MILITARY LAW REVIEW LA English DT Book Review RP OHARE, PD (reprint author), USA,JUDGE ADVOCATE GEN CORPS,DEPT CRIMINAL LAW,CHARLOTTESVILLE,VA 22903, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 1995 VL 147 BP 297 EP 301 PG 5 WC Law SC Government & Law GA TG270 UT WOS:A1995TG27000008 ER PT J AU LAMIELL, JM GRABENSTEIN, JD VANDERHAMM, DGV AF LAMIELL, JM GRABENSTEIN, JD VANDERHAMM, DGV TI REVIEW OF THE 1995 FOOD-AND-DRUG-ADMINISTRATION NATIONAL-INSTITUTES-OF-HEALTH PUBLIC FORUM ON INFORMED CONSENT IN CLINICAL RESEARCH CONDUCTED IN EMERGENCY CIRCUMSTANCES SO MILITARY MEDICINE LA English DT Article AB We describe some of the deliberations and questions raised by the recent Food and Drug Administration/National Institutes of Health Forum on Informed Consent in Clinical Research Conducted in Emergency Circumstances, Consent will have to be waived in emergency medical research if such research is to be conducted, because it is virtually impossible to obtain meaningful informed consent in emergency circumstances, There is clearly a conflict between research subject autonomy and society's perceived need for answers about emergency medical care, Who will resolve this dilemma and how it will be resolved are important questions for modern medicine. RP LAMIELL, JM (reprint author), USA,MED DEPT CTR & SCH,CLIN INVEST REGULATORY OFF,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 1995 VL 160 IS 12 BP 599 EP 603 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA TJ283 UT WOS:A1995TJ28300001 PM 8775381 ER PT J AU ZIMMERMAN, PA FRANCIS, GL POTH, M AF ZIMMERMAN, PA FRANCIS, GL POTH, M TI HORMONE-CONTAINING COSMETICS MAY CAUSE SIGNS OF EARLY SEXUAL DEVELOPMENT SO MILITARY MEDICINE LA English DT Article AB Exogenous hormone exposure can cause early sexual development, but only one report suggests that this may occur secondary to the use of hair-care products, This study evaluated the usage frequency and biological effects of hormone-containing hair-care products, We reviewed the records of 102 consecutive dependent children referred for evaluation of sexual precocity, Eight children (7.8%) were using these products, All eight were black (100%), compared to 57 (61%) of the 94 patients not using such products (p < 0.05). There was no significant difference between these two groups in mean age, sex distribution, height, height standard deviation score, bone age:chronologic age ratio, or serum estradiol level, We conclude that exposure to hormones in hair-care products may be more frequent than expected and should be considered in the differential diagnosis of early sexual development in children. RP ZIMMERMAN, PA (reprint author), WALTER REED ARMY MED CTR,DEPT PEDIAT ENDOCRINOL,WASHINGTON,DC 20307, USA. NR 0 TC 26 Z9 28 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 1995 VL 160 IS 12 BP 628 EP 630 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA TJ283 UT WOS:A1995TJ28300010 PM 8775390 ER PT J AU STAGLIANO, RF RICHARDS, JD KUEHR, W DEAL, CE AF STAGLIANO, RF RICHARDS, JD KUEHR, W DEAL, CE TI OPERATION DESERT SHIELD/STORM PERFORMANCE OF SOLDIERS ENROLLED IN THE ALCOHOL AND DRUG-ABUSE PREVENTION AND CONTROL PROGRAM SO MILITARY MEDICINE LA English DT Article AB This article explores the Operation Desert Shield/Storm performance of soldiers receiving predeployment treatment in the Alcohol and Drug Abuse Prevention and Control Program (ADAPCP), It describes the impact that ADAPCP soldiers' performance has on their units, both from the soldiers' and the leadership's points of view, Examination of the ADAPCP's predeployment and deployment role indicates that the ADAPCP can do more for soldiers who, while attempting to overcome substance abuse problems, face the new challenge of coping with the upheaval of deployment to a war zone, Suggestions are also made for developing an ADAPCP peace-to-war transition plan. RP STAGLIANO, RF (reprint author), USA,MED COMMAND,DIV HUMAN RESOURCES MANAGEMENT,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 1995 VL 160 IS 12 BP 631 EP 635 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA TJ283 UT WOS:A1995TJ28300011 PM 8775391 ER PT J AU WATANABE, H JENSEN, PS NEWBY, J CORTES, RM AF WATANABE, H JENSEN, PS NEWBY, J CORTES, RM TI THE EXCEPTIONAL FAMILY MEMBER PROGRAM - PERCEPTIONS OF ACTIVE-DUTY ENROLLEES SO MILITARY MEDICINE LA English DT Article AB Fifty-four soldiers who had a family member enrolled in the Army Exceptional Family Member Program (EFMP) were surveyed as to their experiences and perceptions of the program, A high percentage of these soldiers reported satisfaction with treatment of the EFMP family member, They generally perceived the EFMP positively and were very supportive of the program, The majority of these soldiers also reported that their units were supportive of them and that they encountered no significant obstacles to career advancement. RP WATANABE, H (reprint author), WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,DIV NEUROPSYCHIAT,WASHINGTON,DC 20005, USA. OI Jensen, Peter/0000-0003-2387-0650 NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 1995 VL 160 IS 12 BP 639 EP 643 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA TJ283 UT WOS:A1995TJ28300013 PM 8775393 ER PT J AU NISHIMOTO, PW AF NISHIMOTO, PW TI SEX AND SEXUALITY IN THE CANCER-PATIENT SO NURSE PRACTITIONER FORUM-CURRENT TOPICS AND COMMUNICATIONS LA English DT Article ID MORBIDITY AB The number of cancer survivors is increasing dramatically. Advanced Practice Nurses (APNs) will have the opportunity to work with cancer survivors as part of their clinical practice and can have influence on the cancer survivor's sexuality as part of the normalization process. Consequently, the cancer survivor's journey will be much richer with an even greater potential for a better quality of life. Copyright (C) 1995 by W.B. Saunders Company C1 UNIV HAWAII MANOA,HONOLULU,HI 96822. RP NISHIMOTO, PW (reprint author), TRIPLER ARMY MED CTR,HEMATOL ONCOL CLIN,HONOLULU,HI 96859, USA. NR 46 TC 4 Z9 4 U1 1 U2 2 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 1045-5485 J9 NURS PRACT FORUM JI Nurse Pract. Forum-Curr. Top. Commun. PD DEC PY 1995 VL 6 IS 4 BP 221 EP 227 PG 7 WC Nursing SC Nursing GA TJ370 UT WOS:A1995TJ37000010 PM 8547812 ER PT J AU Gao, HH Chen, ZP Kumar, J Tripathy, SK Kaplan, DL AF Gao, HH Chen, ZP Kumar, J Tripathy, SK Kaplan, DL TI Tapered fiber tips for fiber optic biosensors SO OPTICAL ENGINEERING LA English DT Article DE fiber optic biosensor; chemiluminescence; sol-gel; fluorescence; alkaline phosphatase AB Tapered fiber tips with different geometries are fabricated for developing a fiber optic biosensor. Fluorescence experiments are performed to compare the coupling efficiency of light for different fiber tip configurations. When light is generated in a ''thick'' layer (>1 mu m) around a fiber core, the continuously tapered tip with the steepest taper collects light more efficiently than the longer combination tapered tip, To demonstrate the applicability of our results, we have successfully detected weak chemiluminescent signal collected by a bundle of fibers with the short continuously tapered tips using a cooled CCD array detector. The chemiluminescence reaction was catalyzed by alkaline phosphatase immobilized on the fiber tips by a set-gel technique. C1 UNIV LOWELL,DEPT PHYS,CTR ADV MAT,LOWELL,MA 01854. UNIV LOWELL,DEPT CHEM,CTR ADV MAT,LOWELL,MA 01854. USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. NR 11 TC 29 Z9 32 U1 0 U2 1 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD DEC PY 1995 VL 34 IS 12 BP 3465 EP 3470 DI 10.1117/12.215379 PG 6 WC Optics SC Optics GA TK812 UT WOS:A1995TK81200016 ER PT J AU CHANDRA, S ALLIK, TH HUTCHINSON, JA AF CHANDRA, S ALLIK, TH HUTCHINSON, JA TI NONCONFOCAL UNSTABLE RESONATOR FOR SOLID-STATE DYE-LASERS BASED ON A GRADIENT-REFLECTIVITY MIRROR SO OPTICS LETTERS LA English DT Article AB A compact high-brightness solid-state dye laser, consisting of a nonconfocal unstable resonator formed of a planar mirror and a gradient-reflectivity mirror, is modeled by use of ray-tracing analysis. Collimated 80-mJ output was obtained in a 10-mm mrad beam. (C) 1995 Optical Society of America C1 USA,CECOM,NIGHT VIS & ELECTR SENSORS DIRECTORATE,FT BELVOIR,VA 22060. RP CHANDRA, S (reprint author), SCI APPLICAT INT CORP,1710 GOODRIDGE DR,MCLEAN,VA 22102, USA. NR 8 TC 14 Z9 14 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD DEC 1 PY 1995 VL 20 IS 23 BP 2387 EP 2389 DI 10.1364/OL.20.002387 PG 3 WC Optics SC Optics GA TH459 UT WOS:A1995TH45900011 PM 19865228 ER PT J AU Federici, JF Chew, D Welker, B Savin, W GutierrezSolana, J Fink, T Wilber, W AF Federici, JF Chew, D Welker, B Savin, W GutierrezSolana, J Fink, T Wilber, W TI Defect mechanism of photoinduced superconductivity in YBa2Cu3O6+x SO PHYSICAL REVIEW B LA English DT Article ID THERMALLY STIMULATED LUMINESCENCE; HIGH-TC-SUPERCONDUCTORS; HIGH-TEMPERATURE SUPERCONDUCTORS; OXYGEN-DEFICIENT YBA2CU3OX; BA-CU-O; PERSISTENT PHOTOCONDUCTIVITY; PHASE-SEPARATION; YBACUO FILMS; CATHODOLUMINESCENCE AB Although persistent photoconductivity and photoinduced superconductivity have been experimentally observed in oxygen-deficient and superconducting YBa2Cu3O6+x, the mechanism which is responsible for these effects is still under debate. The possibility of a defect related mechanism in laser-deposited thin films of YBa2Cu3O6+x is studied using four-point resistivity and photoluminescence techniques. It is found that there is a correlation between the photoluminescence spectrum and the wavelength dependence of the photoinduced conductivity. Peaks in the luminescence spectrum change intensity upon initiation of the photoinduced state. These results support an oxygen vacancy defect model of photoinduced persistent conductivity and superconductivity in which the oxygen vacancies act as weakly luminescent F-centers under illumination. C1 USA,RES LAB,PHYS SCI DIRECTORATE,FT MONMOUTH,NJ 07703. RP Federici, JF (reprint author), NEW JERSEY INST TECHNOL,DEPT PHYS,NEWARK,NJ 07102, USA. NR 29 TC 37 Z9 38 U1 0 U2 6 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD DEC 1 PY 1995 VL 52 IS 21 BP 15592 EP 15597 DI 10.1103/PhysRevB.52.15592 PG 6 WC Physics, Condensed Matter SC Physics GA TK979 UT WOS:A1995TK97900079 ER PT J AU WINDHAM, J AF WINDHAM, J TI IMPLEMENTING DEMING 4TH POINT SO QUALITY PROGRESS LA English DT Article RP WINDHAM, J (reprint author), USA,CTR ARMAMENT RES DEV & ENGN,ROCK ISL,IL, USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC QUALITY CONTROL-ASQC PI MILWAUKEE PA ASQC MEMBERSHIP MANAGER 611 E. WISCONSIN AVENUE, MILWAUKEE, WI 53202 SN 0033-524X J9 QUAL PROG JI Qual. Prog. PD DEC PY 1995 VL 28 IS 12 BP 43 EP 48 PG 6 WC Engineering, Multidisciplinary; Engineering, Industrial; Management; Operations Research & Management Science SC Engineering; Business & Economics; Operations Research & Management Science GA TJ113 UT WOS:A1995TJ11300018 ER PT J AU Burris, HA Fields, S Peacock, N AF Burris, HA Fields, S Peacock, N TI Docetaxel (Taxotere) in combination: A step forward SO SEMINARS IN ONCOLOGY LA English DT Article; Proceedings Paper CT Satellite Symposium on Management of Breast Cancer - A New Therapeutic Approach, at the 19th International Congress of Chemotherapy CY JUL 16-21, 1995 CL MONTREAL, CANADA SP Rhone Poulenc Rorer C1 BROOKE ARMY MED CTR,HEMATOL ONCOL SERV,DRUG DEV PROGRAM,FT SAM HOUSTON,TX 78234. RP Burris, HA (reprint author), CANC THERAPY & RES CTR S TEXAS,CLIN INVEST OFF,8122 DATAPOINT DR,SUITE 1000,SAN ANTONIO,TX 78229, USA. NR 22 TC 14 Z9 14 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0093-7754 J9 SEMIN ONCOL JI Semin. Oncol. PD DEC PY 1995 VL 22 IS 6 SU 13 BP 35 EP 40 PG 6 WC Oncology SC Oncology GA TM976 UT WOS:A1995TM97600006 PM 8604452 ER PT J AU BLANK, S AF BLANK, S TI THE END OF THE SOVIET EMPIRE - THE TRIUMPH OF THE NATIONS - CARREREDENCAUSSE,H SO SLAVIC REVIEW LA English DT Book Review RP BLANK, S (reprint author), US ARMY WAR COLL,CARLISLE,PA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC ADVANCEMENT SLAVIC STUDIES PI STANFORD PA JORDAN QUAD/ACACIA, STANFORD UNIV, 125 PANAMA ST, STANFORD, CA 94305-4130 SN 0037-6779 J9 SLAVIC REV JI Slavic Rev. PD WIN PY 1995 VL 54 IS 4 BP 1134 EP 1135 DI 10.2307/2501492 PG 2 WC Area Studies; Humanities, Multidisciplinary SC Area Studies; Arts & Humanities - Other Topics GA UD819 UT WOS:A1995UD81900109 ER PT J AU Will, MJ Ester, MS Ramirez, SG Tiner, BD McAnear, JT Epstein, L AF Will, MJ Ester, MS Ramirez, SG Tiner, BD McAnear, JT Epstein, L TI Comparison of cephalometric analysis with ethnicity in obstructive sleep apnea syndrome SO SLEEP LA English DT Article DE cephalometric anaylsis; ethnicity; obstructive sleep apnea ID ROENTGENOGRAMS; ABNORMALITIES AB Many studies have documented significant craniomandibular abnormalities in obstructive sleep apnea syndrome (OSAS) patients. Recent literature clearly describes the cephalometric abnormalities commonly associated with OSAS. Studies have not evaluated specific cephalometric abnormalities that may contribute to OSAS by various ethnic groups. Data were collected on 48 patients (20 Caucasian, 15 Black and 13 Hispanic) with completed cephalometric analysis and polysomnography. Cephalometric landmarks, angles and measurements [angle measured from sella to nasion to subspinale point (SNA), angle measured from sella to nasion to supramentale point (SNB), difference between SNA and SNB (ANB), perpendicular distance from gonion to gnathion to hyoid (MP-H), distance from posterior nasal spine to tip of soft palate (PNS-P) and posterior airway space (PAS)] commonly used in the evaluation of OSAS patients were recorded. Measurements were normalized by dividing the observed value by the mean value for the ethnic group. Statistically significant differences in normalized SNA and SNB appeared in the Black and Hispanic groups when compared to the Caucasian group. For both SNA and SNB, Blacks averaged approximately 3.5% above their ethnic mean, whereas Hispanics averaged 1.8-2.8% below their ethnic mean. There was a statistically significant correlation between respiratory distress index (RDI) and MP-H. These baseline cephalometric differences in the ethnic groups studied suggest that surgical intervention might be approached differently in various ethnic groups. Further studies that evaluate the surgical success achieved by various procedures among different ethnic groups may help define surgical protocol in various ethnic groups for OSAS. C1 UNIV TEXAS,HLTH SCI CTR,DEPT PSYCHIAT & SLEEP DISORDERS,SAN ANTONIO,TX. UNIV TEXAS,HLTH SCI CTR,DEPT ORAL & MAXILLOFACIAL SURG,SAN ANTONIO,TX 78284. AUDIE L MURPHY MEM VET ADM MED CTR,DEPT ORAL & MAXILLOFACIAL SURG,SAN ANTONIO,TX 78284. WILFORD HALL USAF MED CTR,DEPT PULM & SLEEP MED,LACKLAND AFB,TX 78236. RP Will, MJ (reprint author), BROOKE ARMY MED CTR,DEPT ORAL & MAXILLOFACIAL SURG,FT SAM HOUSTON,TX 78234, USA. NR 11 TC 32 Z9 32 U1 0 U2 2 PU AMER SLEEP DISORDERS ASSOC PI ROCHESTER PA 1610 14TH STREET NW SUITE 300, ROCHESTER, MN 55806 SN 0161-8105 J9 SLEEP JI Sleep PD DEC PY 1995 VL 18 IS 10 BP 873 EP 875 PG 3 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA TQ236 UT WOS:A1995TQ23600008 PM 8746394 ER PT J AU Lee, YTM AF Lee, YTM TI Local and regional recurrence of carcinoma of the colon and rectum .1. Tumour-host factors and adjuvant therapy SO SURGICAL ONCOLOGY-OXFORD LA English DT Review DE colon cancer; rectum cancer; recurrence ID LARGE-BOWEL-CANCER; POTENTIALLY CURATIVE SURGERY; COLORECTAL-CANCER; POSTOPERATIVE RADIOTHERAPY; PREOPERATIVE IRRADIATION; RADIATION-THERAPY; RESECTION; ADENOCARCINOMA; PATTERNS; FAILURE AB A review of 13 studies (published from 1976 to 1991) shows that the mean loco-regional recurrence rate after resection of colorectal carcinoma is 17%, and nearly one-third of these had only a loco-regional relapse. Approximately half of the pelvic recurrences of rectal cancer appeared within 1 year, and half of the colonic loco-regional recurrences within 2 years. Among 5336 patients studied, there was a progressively higher locoregional recurrence rate with increased pathological stages: the medians were 2%, 7%, 19%, 21% and 32%, respectively, for Dukes A, B1, B2, C1 and C2 lesions. Other significant prognostic factors include the age of the patient, site of the primary tumour, mucinous subtype, degree of differentiation and vascular or lymphatic invasion. For resected rectal cancers, adjuvant radiotherapy has decreased loco-regional recurrence by 20-30%, especially when it is given preoperatively and/or with added systemic chemotherapy. These quantitative loco-regional recurrence data were collected before systemic adjuvant chemotherapy and radiotherapy were popularized, and before laparoscopic minimal invasive surgery was widely practiced. Thus, they are a useful baseline of information to study the changes in rates and types of relapse in the future. RP Lee, YTM (reprint author), TRIPLER ARMY MED CTR,DEPT SURG,GEN SURG SERV,HONOLULU,HI 96859, USA. NR 41 TC 16 Z9 16 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0960-7404 J9 SURG ONCOL JI Surg. Oncol.-Oxf. PD DEC PY 1995 VL 4 IS 6 BP 283 EP 293 PG 11 WC Oncology; Surgery SC Oncology; Surgery GA UU891 UT WOS:A1995UU89100001 PM 8809950 ER PT J AU LAUMAKIS, PJ HARLOW, DG AF LAUMAKIS, PJ HARLOW, DG TI ASYMPTOTIC APPROXIMATIONS USED IN PROBABILISTIC FAILURE MODELING OF WOVEN FIBER NETWORKS SO TEXTILE RESEARCH JOURNAL LA English DT Article ID LOAD-SHARING SYSTEMS; COMPOSITE-MATERIALS; STRENGTH; DISTRIBUTIONS; BOUNDS AB Approximate numerical results for the strength distributions of large woven fiber networks are given. The system under consideration consists of fibers arranged in a mutually orthogonal, simple weave pattern. The goal is to estimate the cumulative distribution function for failure of the network as a function of the fiber properties and the failure mechanism. Based on a two-dimensional load sharing model developed earlier and appropriate asymptotic theory, we have constructed conservative upper bound approximations for arbitrarily large networks. Additionally, we have introduced a translation ratio that may be used to relate the lower tail behavior of diverse networks experiencing different biaxial loading conditions. C1 LEHIGH UNIV,DEPT MECH ENGN & MECH,BETHLEHEM,PA 18015. RP LAUMAKIS, PJ (reprint author), US MIL ACAD,DEPT MATH SCI,W POINT,NY 10996, USA. NR 9 TC 2 Z9 2 U1 0 U2 0 PU TEXTILE RESEARCH INST PI PRINCETON PA PO BOX 625, PRINCETON, NJ 08540 SN 0040-5175 J9 TEXT RES J JI Text. Res. J. PD DEC PY 1995 VL 65 IS 12 BP 731 EP 738 DI 10.1177/004051759506501205 PG 8 WC Materials Science, Textiles SC Materials Science GA TH320 UT WOS:A1995TH32000005 ER PT J AU Ulrich, RG Bavari, S Olson, MA AF Ulrich, RG Bavari, S Olson, MA TI Bacterial superantigens in human disease: Structure, function and diversity SO TRENDS IN MICROBIOLOGY LA English DT Article ID TOXIC SHOCK SYNDROME; AUREUS ENTEROTOXIN-B; STAPHYLOCOCCUS-AUREUS; T-CELLS; ACTIVATION; DETERMINANTS; LYMPHOCYTES; DEATH AB All bacterial superantigens use common structural strategies to bind to major histocompatibility complex class II receptors, while binding the T cell antigen receptor in different ways. Overstimulation of the immune response is responsible for the acute pathological effects, while reactivation of developmentally silenced T cells might result in autoimmune disease. Certain diseases might be controlled with superantigens or genetically attenuated vaccines. C1 USA,MED RES INST INFECT DIS,DEPT IMMUNOL & MOLEC BIOL,FREDERICK,MD 21701. USA,MED RES INST INFECT DIS,DEPT CELL BIOL & BIOCHEM,FREDERICK,MD 21701. NR 51 TC 46 Z9 47 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0966-842X J9 TRENDS MICROBIOL JI Trends Microbiol. PD DEC PY 1995 VL 3 IS 12 BP 463 EP 468 DI 10.1016/S0966-842X(00)89011-3 PG 6 WC Biochemistry & Molecular Biology; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA TK864 UT WOS:A1995TK86400006 PM 8800837 ER PT J AU SRIVASTAVA, S KATAYOSE, D TONG, YA CRAIG, CR MCLEOD, DG MOUL, JW COWAN, KH SETH, P AF SRIVASTAVA, S KATAYOSE, D TONG, YA CRAIG, CR MCLEOD, DG MOUL, JW COWAN, KH SETH, P TI RECOMBINANT ADENOVIRUS VECTOR EXPRESSING WILD-TYPE P53 IS A POTENT INHIBITOR OF PROSTATE-CANCER CELL-PROLIFERATION SO UROLOGY LA English DT Article ID CARCINOMA; SUPPRESSION; GROWTH; GENE; PROTEIN; MUTANT AB Objectives. A recombinant adenovirus vector (AdWTp53) expressing wild-type p53 was evaluated for its cell growth inhibitory effects on metastatic human prostate cancer cells. Methods. Human prostate cancer cells LNCaP, DU145, PC3, 1LN, and DUPro-1 were infected with AdWTp53 vector and expression of exogenous p53 in these cells was analyzed by immunoprecipitation and western blot assays. The cell growth inhibitory effects of AdWTp53 were determined by counting cell number on a hemocytometer or by crystal violet staining of cells after infection with AdWTp53. The p53-regulated gene WAF1 and DNA fragmentation were also analyzed in prostate cancer cells infected with AdWTp53. Results. High levels of the AdWTp53 vector-derived p53 protein were present in metastatic prostate cancer cells, and the p53-regulated gene WAF1 was induced in these cells. Infection of these tumor cell lines with AdWTp53 vector resulted in severe growth inhibition and cell death in comparison to untreated or control adenovirus vector-infected cells. Furthermore, fragmentation of genomic DNA, a property associated with apoptosis, was also observed in prostate cancer cells infected with AdWTp53. Conclusions. AdWTp53 vector exhibited a potent inhibitory effect on the growth of all of human metastatic prostate cancer cells, and both cytostatic and cytotoxic effects of AdWTp53 were observed. The induction of p53-regulated gene WAF1 in AdWTp53-infected prostate cancer cells suggests the involvement of cellular p53 pathway in the cell growth inhibition. These results provide a molecular basis for further evaluation of antitumorigenic effects of AdWTp53 vector in animal models of prostate cancer. C1 WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307. NCI,MED BRANCH,MED BREAST SECT,BETHESDA,MD 20892. RP SRIVASTAVA, S (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,CTR PROSTATE DIS RES,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 32 TC 41 Z9 42 U1 0 U2 1 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD DEC PY 1995 VL 46 IS 6 BP 843 EP 848 DI 10.1016/S0090-4295(99)80355-0 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA TJ347 UT WOS:A1995TJ34700017 PM 7502427 ER PT J AU Ivins, B Fellows, P Pitt, L Estep, J Farchaus, J Friedlander, A Gibbs, P AF Ivins, B Fellows, P Pitt, L Estep, J Farchaus, J Friedlander, A Gibbs, P TI Experimental anthrax vaccines: Efficacy of adjuvants combined with protective antigen against an aerosol Bacillus anthracis spore challenge in guinea pigs SO VACCINE LA English DT Article DE anthrax; Bacillus anthracis; vaccine efficacy ID VIRUS VACCINE; ANTIBODIES; IMMUNITY; IMMUNIZATION; FORMULATION; RELEVANCE; SUBTILIS; HUMANS; TOXIN AB The efficacy of several human anthrax vaccine candidates comprised of different adjuvants together with Bacillus anthracis protective antigen (PA) was evaluated in guinea pigs challenged by an aerosol of virulent B. anthracis spores. The most efficacious vaccines tested were formulated with PA plus monophosphoryl lipid A (MPL) in a squalene/lecithin/Tween 80 emulsion (SLT) and PA plus the saponin QS-21. The PA+MPL in SLT vaccine, which was lyophilized and then reconstituted before use, demonstrated strong protective immunogenicity, even after storage for 2 years at 4 degrees C. The MPL component was required for maximum efficacy of the vaccine. Eliminating lyophilization of the vaccine did not diminish its protective efficacy. No significant alteration in efficacy was observed when PA was dialyzed against different buffers before preparation of vaccine. PA+MPL in SLT proved superior in efficacy to the licensed United States human anthrax vaccine in the guinea pig model. C1 USA,MED RES INST INFECT DIS,DIV APPL RES,FT DETRICK,FREDERICK,MD 21702. USA,MED RES INST INFECT DIS,DIV BIOMETR & INFORMAT MANAGEMENT,FT DETRICK,FREDERICK,MD 21702. RP Ivins, B (reprint author), USA,MED RES INST INFECT DIS,DIV BACTERIOL,FT DETRICK,FREDERICK,MD 21702, USA. NR 44 TC 72 Z9 74 U1 0 U2 4 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD DEC PY 1995 VL 13 IS 18 BP 1779 EP 1784 DI 10.1016/0264-410X(95)00139-R PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA TM897 UT WOS:A1995TM89700008 PM 8701593 ER PT J AU Geisbert, TW Jahrling, PB AF Geisbert, TW Jahrling, PB TI Differentiation of filoviruses by electron microscopy SO VIRUS RESEARCH LA English DT Article DE Ebola; Marburg; Reston; filoviridae; ultrastructure; electron microscopy ID EBOLA VIRUS; MARBURG VIRUS; IMMUNOELECTRON MICROSCOPY; SEQUENCE-ANALYSIS; UNITED-STATES; MONKEYS; INFECTION; STRAINS; ORGANIZATION; PARTICLES AB Cultured monolayers of MA-104, Vero 76, SW-13, and DBS-FRhL-2 cells were infected with Marburg (MEG), Ebola-Sudan (EBO-S), Ebola-Zaire (EBO-Z), and Ebola-Reston (EBO-R) viruses (Filoviridae, Filovirus) and examined by electron microscopy to provide ultrastructural details of morphology and morphogenesis of these potential human pathogens. Replication of each filovirus was seen in all cell systems employed. Filoviral particles appeared to enter host cells by endocytosis. Filoviruses showed a similar progression of morphogenic events, from the appearance of nascent intracytoplasmic viral inclusions to formation of mature virions budded through plasma membranes, regardless of serotype or host cell. However, ultrastructural differences were demonstrated between MBG and other filoviruses. MBG virions recovered from culture fluids were uniformly shorter in mean unit length than EBO-S, EBO-Z, or EBO-R particles. Examination of filovirus-infected cells revealed that intermediate MBG inclusions were morphologically distinct from EBO-S, EBO-Z, and EBO-R inclusions. No structural difference of viral inclusion material was observed among EBO-S, EBO-Z, and EBO-R. Immunoelectron microscopy showed that the filoviral matrix protein (VP40) and nucleoprotein (NP) accumulated in EBO-Z inclusions, and were closely associated during viral morphogenesis. These details facilitate the efficient and definitive diagnosis of filoviral infections by electron microscopy. C1 USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21702. RP Geisbert, TW (reprint author), USA,MED RES INST INFECT DIS,DIV PATHOL,FREDERICK,MD 21702, USA. NR 38 TC 144 Z9 155 U1 0 U2 16 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-1702 J9 VIRUS RES JI Virus Res. PD DEC PY 1995 VL 39 IS 2-3 BP 129 EP 150 DI 10.1016/0168-1702(95)00080-1 PG 22 WC Virology SC Virology GA TU783 UT WOS:A1995TU78300004 PM 8837880 ER PT J AU ALIABADI, SK TEZDUYAR, TE AF ALIABADI, SK TEZDUYAR, TE TI PARALLEL FLUID-DYNAMICS COMPUTATIONS IN AEROSPACE APPLICATIONS SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS LA English DT Article DE PARALLEL FINITE ELEMENTS; 3D COMPRESSIBLE FLOWS; STABILIZED METHOD; SPACE-TIME METHOD ID FINITE-ELEMENT FORMULATION; ADVECTIVE-DIFFUSIVE SYSTEMS; FLOWS; ALGORITHM; OPERATOR; GMRES AB Massively parallel finite element computations of the compressible Euler and Navier-Stokes equations using parallel supercomputers are presented. The finite element formulations are based on the conservation variables and the streamline-upwind/Petrov-Galerkin (SUPG) stabilization method is used to prevent potential numerial oscillations due to dominant advection terms. These computations are based on both implicit and explicit methods and their parallel implementation assumes that the mesh is unstructured. The implicit computations are based on iterative strategies. Large-scale 3D problems are solved using a matrix-free iteration technique which reduces the memory requirements significantly. The flow problems we consider typically come from aerospace applications, including those in 3D and those involving moving boundaries interacting with boundary layers and shocks. Problems with fixed boundaries are solved using a semidiscrete formulation and the ones involving moving boundaries are solved using the deformable-spatial-domain/stabilized-space-time (DSD/SST) formulation. C1 UNIV MINNESOTA, USA, HIGH PERFORMANCE COMP RES CTR, MINNEAPOLIS, MN 55415 USA. RP ALIABADI, SK (reprint author), UNIV MINNESOTA, DEPT AEROSP ENGN & MECH, 1100 WASHINGTON AVE S, MINNEAPOLIS, MN 55415 USA. RI Tezduyar, Tayfun/F-6134-2012 OI Tezduyar, Tayfun/0000-0001-8707-3162 NR 35 TC 57 Z9 58 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0271-2091 J9 INT J NUMER METH FL JI Int. J. Numer. Methods Fluids PD NOV 30 PY 1995 VL 21 IS 10 BP 783 EP 805 DI 10.1002/fld.1650211003 PG 23 WC Computer Science, Interdisciplinary Applications; Mathematics, Interdisciplinary Applications; Mechanics; Physics, Fluids & Plasmas SC Computer Science; Mathematics; Mechanics; Physics GA TH690 UT WOS:A1995TH69000002 ER PT J AU MITTAL, S TEZDUYAR, TE AF MITTAL, S TEZDUYAR, TE TI PARALLEL FINITE-ELEMENT SIMULATION OF 3D INCOMPRESSIBLE FLOWS - FLUID-STRUCTURE INTERACTIONS SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS LA English DT Article; Proceedings Paper CT 2nd Japan/US Symposium on Finite Element Methods in Large-Scale Computational Fluid Dynamics CY MAR 14-16, 1994 CL CHUO UNIV, TOKYO, JAPAN SP Chuo Univ, Inst Sci & Engn HO CHUO UNIV DE PARALLEL FINITE ELEMENTS; 3D INCOMPRESSIBLE FLOWS; FLUID-STRUCTURE INTERACTIONS AB Massively parallel finite element computations of 3D, unsteady incompressible flows, including those involving fluid-structure interactions, are presented. The computations with time-varying spatial domains are based on the deforming spatial domain/stabilized space-time (DSD/SST) finite element formulation. The capability to solve 3D problems involving fluid-structure interactions is demonstrated by investigating the dynamics of a flexible cantilevered pipe conveying fluid. Computations of flow past a stationary rectangular wing at Reynolds number 1000, 2500 and 10(7) reveal interesting flow patterns. In these computations, at each time step approximately 3 x 10(6) non-linear equations are solved to update the flow field. Also, preliminary results are presented for flow past a wing in flapping motion. In this case a specially designed mesh moving scheme is employed to eliminate the need for remeshing. All these computations are carried out on the Army High Performance Computing Research Center supercomputers CM-200 and CM-5, with major speed-ups compared with traditional supercomputers. The coupled equation systems arising from the finite element discretizations of these large-scale problems are solved iteratively with diagonal preconditioners. In some cases, to reduce the memory requirements even further, these iterations are carried out with a matrix-free strategy. The finite element formulations and their parallel implementations assume unstructured meshes. C1 UNIV MINNESOTA, USA, HPC RES CTR, MINNEAPOLIS, MN 55415 USA. RP MITTAL, S (reprint author), INDIAN INST TECHNOL, KANPUR 208016, UTTAR PRADESH, INDIA. RI Tezduyar, Tayfun/F-6134-2012 OI Tezduyar, Tayfun/0000-0001-8707-3162 NR 18 TC 109 Z9 109 U1 1 U2 15 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0271-2091 J9 INT J NUMER METH FL JI Int. J. Numer. Methods Fluids PD NOV 30 PY 1995 VL 21 IS 10 BP 933 EP 953 DI 10.1002/fld.1650211011 PG 21 WC Computer Science, Interdisciplinary Applications; Mathematics, Interdisciplinary Applications; Mechanics; Physics, Fluids & Plasmas SC Computer Science; Mathematics; Mechanics; Physics GA TH690 UT WOS:A1995TH69000010 ER PT J AU WREN, GP RAY, SE ALIABADI, SK TEZDUYAR, TE AF WREN, GP RAY, SE ALIABADI, SK TEZDUYAR, TE TI SPACE-TIME FINITE-ELEMENT COMPUTATION OF COMPRESSIBLE FLOWS BETWEEN MOVING COMPONENTS SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS LA English DT Article; Proceedings Paper CT 2nd Japan/US Symposium on Finite Element Methods in Large-Scale Computational Fluid Dynamics CY MAR 14-16, 1994 CL CHUO UNIV, TOKYO, JAPAN SP Chuo Univ, Inst Sci & Engn HO CHUO UNIV DE FINITE ELEMENTS; COMPRESSIBLE FLOW; SPACE-TIME FORMULATION; MOVING COMPONENTS AB A numerical simulation capability for the injector flow of a regenerative liquid propellant gun (RLPG) is presented. The problem involves fairly complex geometries and two pistons in relative motion; therefore a stabilized space-time finite element formulation developed earlier and capable of handling flows with moving mechanical components is used. In addition to the specifics of the numerical method, its application to a 30 mm RLPG test firing is discussed. The computational data from the simulation of this test case are interpreted to provide information on flow characteristics, with emphasis on the tendency of the flow to separate from the injection orifice boundary of the test problem. In addition, the computations provided insight into the behaviour of the flow entering the combustion chamber. C1 UNIV MINNESOTA,DEPT AEROSP ENGN & MECH,MINNEAPOLIS,MN 55415. UNIV MINNESOTA,USA,HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55415. RP WREN, GP (reprint author), USA,RES LAB,WEAPONS TECHNOL DIRECTORATE,ABERDEEN PROVING GROUND,MD 21005, USA. RI Tezduyar, Tayfun/F-6134-2012 OI Tezduyar, Tayfun/0000-0001-8707-3162 NR 8 TC 6 Z9 6 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0271-2091 J9 INT J NUMER METH FL JI Int. J. Numer. Methods Fluids PD NOV 30 PY 1995 VL 21 IS 10 BP 981 EP & DI 10.1002/fld.1650211015 PG 0 WC Computer Science, Interdisciplinary Applications; Mathematics, Interdisciplinary Applications; Mechanics; Physics, Fluids & Plasmas SC Computer Science; Mathematics; Mechanics; Physics GA TH690 UT WOS:A1995TH69000014 ER PT J AU ZIAO, Q SALINGER, AG ZHOU, YI DERBY, JJ AF ZIAO, Q SALINGER, AG ZHOU, YI DERBY, JJ TI MASSIVELY-PARALLEL FINITE-ELEMENT ANALYSIS OF COUPLED, INCOMPRESSIBLE FLOWS - A BENCHMARK COMPUTATION OF BAROCLINIC ANNULUS WAVES SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS LA English DT Article; Proceedings Paper CT 2nd Japan/US Symposium on Finite Element Methods in Large-Scale Computational Fluid Dynamics CY MAR 14-16, 1994 CL CHUO UNIV, TOKYO, JAPAN SP Chuo Univ, Inst Sci & Engn HO CHUO UNIV DE FINITE ELEMENT; MASSIVELY PARALLEL; COUPLED FLOW; BAROCLINIC ANNULUS WAVES ID CONNECTION MACHINE; CONVECTION; ALGORITHM; GROWTH; MODEL; MELTS AB Coupled, three-dimensional, time-dependent, incompressible flows in a differentially heated, rotating annulus are simulated using a parallel implementation of the Galerkin finite element method on the Connection Machine 5 (CM-5) supercomputer. The development of baroclinic annulus waves is computed and found to be consistent with previous experimental reseults. The implementation of a repeated spectral bisection element-partitioning technique significantly increases the computation speed over a strategy which randomly maps elements to processors, yielding sustained calculation rates of 8.1 GFLOPS on 512 processors of the CM-5. C1 UNIV MINNESOTA,DEPT CHEM ENGN & MAT SCI,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,USA,HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. RI Derby, Jeffrey/B-9706-2009 NR 37 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0271-2091 J9 INT J NUMER METH FL JI Int. J. Numer. Methods Fluids PD NOV 30 PY 1995 VL 21 IS 10 BP 1007 EP 1014 PG 8 WC Computer Science, Interdisciplinary Applications; Mathematics, Interdisciplinary Applications; Mechanics; Physics, Fluids & Plasmas SC Computer Science; Mathematics; Mechanics; Physics GA TH690 UT WOS:A1995TH69000016 ER PT J AU DOOLEY, TP NAIR, SK GARCIA, RE COURTNEY, BC AF DOOLEY, TP NAIR, SK GARCIA, RE COURTNEY, BC TI MOUSE RHODANESE GENE (TST) - CDNA CLONING, SEQUENCING, AND RECOMBINANT PROTEIN EXPRESSION SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article ID BOVINE LIVER RHODANESE; CYANIDE; ENZYME; THIOSULFATE; COVALENT AB Rhodanese (thiosulfate sulfurtransferase) is expressed at high levels in liver and is involved in the detoxification of cyanide. The full-length cDNA corresponding to the mouse rhodanese gene (Tst), which is located on chromosome 15, was cloned by PCR amplification of a liver cDNA library and subjected to DNA sequencing. Alignment of the rhodanese cDNA sequences from mouse and rat, which we previously cloned (Biochem. J. 275:227-231), revealed 97.3 percent identity at the protein level and 94.6 percent identity at the DNA level. When the mouse and rat cDNAs were expressed under the control of IPTG-inducible promoters in E. coli, the cell extracts exhibited cyanide-metabolizing activity, indicating that both genes encode functional rhodanese molecules. (C) 1995 Academic Press, Inc. C1 SW FDN BIOMED RES, DEPT GENET, SAN ANTONIO, TX USA. USA, MED RES INST CHEM DEF, APPL PHARMACOL BRANCH, ABERDEEN PROVING GROUND, MD 21010 USA. NR 29 TC 12 Z9 13 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0006-291X EI 1090-2104 J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD NOV 22 PY 1995 VL 216 IS 3 BP 1101 EP 1109 DI 10.1006/bbrc.1995.2734 PG 9 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA TF713 UT WOS:A1995TF71300051 PM 7488186 ER PT J AU OPTENBERG, SA THOMPSON, IM FRIEDRICHS, P WOJCIK, B STEIN, CR KRAMER, B AF OPTENBERG, SA THOMPSON, IM FRIEDRICHS, P WOJCIK, B STEIN, CR KRAMER, B TI RACE, TREATMENT, AND LONG-TERM SURVIVAL FROM PROSTATE-CANCER IN AN EQUAL-ACCESS MEDICAL-CARE DELIVERY SYSTEM SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID RACIAL-DIFFERENCES; UNITED-STATES; BLACK; ADENOCARCINOMA; MORTALITY; STAGE; POPULATIONS; CARCINOMA; DIAGNOSIS; PATTERNS AB Objective.-To evaluate long-term survival of black and white prostate cancer patients in an equal-access medical care system to help distinguish biological from medical and social explanations of mortality differences. Design and Setting.-Retrospective study of US Department of Defense tumor registry patients with prostate cancer. Ethnicity, age, diagnosis, staging, risk factors, treatment, and survival end points were extracted. Patients.-Prostate cancer patients (N=1606; 7.5% black, 92.5% white) who were active-duty personnel, dependents, or retirees eligible for care in the military medical system. Main Outcome Measuress-Racial differences in tumor stage and grade, risk factors, recurrence, and treatment wait time (time between initial diagnosis and initial treatment); influence of stage, grade, treatment, wait time, age, and race on survival. Results.-No differences were found in behavioral risk factors or tumor grade or size, but blacks entered active treatment (P<.001) and exhibited a higher relative risk of cancer (P=.01) in younger age groups, presented with higher stage (P<.001), and demonstrated increased progression in distant metastatic disease (P=.01). No significant differences were detected in overall wait time. When adjusted for stage, no difference was found in type of treatment. Overall, stage, grade, and age were found to affect survival (P=.04 to P<.001), but race did not, When analyzed by stage, blacks demonstrated a clear trend of longer survival for distant metastatic disease (P=.04 to P=.06). This trend was confirmed using Kaplan-Meier estimates (P=.04, likelihood ratio), Conclusions.-This analysis suggests that in an equal-access medical care system there are no stage-specific differences in treatment between black and white prostate cancer patients, Survival among blacks is similar to that among whites and may surpass it for high-stage disease. C1 USA,MED DEPT CTR & SCH,CTR HLTHCARE EDUC & STUDIES,SAN ANTONIO,TX. BROOKE ARMY MED CTR,UROL SERV,SAN ANTONIO,TX. NCI,DIV CANC PREVENT & CONTROL,BETHESDA,MD. NR 43 TC 178 Z9 181 U1 1 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD NOV 22 PY 1995 VL 274 IS 20 BP 1599 EP 1605 DI 10.1001/jama.274.20.1599 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA TE738 UT WOS:A1995TE73800024 PM 7474244 ER PT J AU FLANIGAN, DF AF FLANIGAN, DF TI CELL FOR TESTING PASSIVE REMOTE-SENSING VAPOR DETECTORS SO APPLIED OPTICS LA English DT Article DE HAZARDOUS VAPOR; REMOTE DETECTION; INFRARED; VAPOR CELL AB There is a requirement for the controlled testing of passive infrared remote-sensing vapor detectors. The driving mechanism for the operation of these sensors is the small temperature difference Delta T that occurs between the target vapor and the background. Natural Delta T's, ranging from a fraction of a degree Kelvin to 20 K or more, have to be duplicated in the laboratory with the vapor contained in a cell. It is shown that the windows of the cell nonlinearly affect the measurements. A proposal is made for a new type of vapor cell, the ectocell, which effectively eliminates the window problems for differential measurements. (C) 1995 Optical Society of America RP FLANIGAN, DF (reprint author), USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010, USA. NR 6 TC 1 Z9 1 U1 2 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD NOV 20 PY 1995 VL 34 IS 33 BP 7714 EP 7717 PG 4 WC Optics SC Optics GA TE199 UT WOS:A1995TE19900011 PM 21060652 ER PT J AU ANDERSON, SL BERMAN, J KUSCHNER, R WESCHE, D MAGILL, A WELLDE, B SCHNEIDER, I DUNNE, M SCHUSTER, BG AF ANDERSON, SL BERMAN, J KUSCHNER, R WESCHE, D MAGILL, A WELLDE, B SCHNEIDER, I DUNNE, M SCHUSTER, BG TI PROPHYLAXIS OF PLASMODIUM-FALCIPARUM MALARIA WITH AZITHROMYCIN ADMINISTERED TO VOLUNTEERS SO ANNALS OF INTERNAL MEDICINE LA English DT Note ID MEFLOQUINE AB Objective: To determine whether azithromycin, 250 mg/d, is effective prophylaxis for liver infection or for both liver and subsequent blood infection with Plasmodium falciparum. Design: Controlled phase II trial with two cohorts entered sequentially. Setting: Clinical trials center of Waiter Reed Army Institute of Research, Washington, D.C. Patients: Each of the two cohorts consisted of 12 normal adult volunteers who had not had malaria during the previous 2 years: 10 who received azithromycin prophylaxis and 2 controls who did not receive treatment. Intervention: For cohort 1, prophylactic efficacy against liver infection alone during the initial 7 days of the infection was determined by loading participants with azithromycin before challenge with P falciparum-infected mosquitoes on day 0 and by then giving the drug for 7 days after the challenge. The regimen was 500 mg on day 14 before the challenge, followed by 250 mg/d from day 13 before the challenge through day 7 after the challenge. For cohort 2, prophylactic efficacy against both the liver infection and the subsequent blood infection was determined by continuing drug administration for 28 days after the challenge. Measurements: Plasmodium falciparum infection was diagnosed through peripheral blood smears obtained up to 70 days after challenge. Malarial symptoms and adverse drug reactions were also monitored. Results: In cohort 1,4 of 10 volunteers who received azithromycin prophylaxis (40%) did not develop parasitemia. In cohort 2, none of the 10 volunteers receiving azithromycin prophylaxis (100%) developed parasitemia. For each cohort, both control volunteers became parasitemic on days 9 through 13 after the challenge. Adverse drug reactions were few and mild. Conclusions: In this model, prophylaxis with azithro-mycin (250 mg/d) was partially effective against liver parasites and completely successful against the combination of liver and blood parasites. These data suggest that azithromycin has the potential to be an effective, well-tolerated clinical prophylactic agent for P. falciparum malaria. C1 PFIZER INC,CENT RES,GROTON,CT 06340. RP ANDERSON, SL (reprint author), WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 9 TC 56 Z9 59 U1 0 U2 1 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD NOV 15 PY 1995 VL 123 IS 10 BP 771 EP 773 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA TE172 UT WOS:A1995TE17200005 PM 7574195 ER PT J AU BURKE, DS BROWN, AE AF BURKE, DS BROWN, AE TI SCREENING SURGEONS FOR HIV-INFECTION SO ANNALS OF INTERNAL MEDICINE LA English DT Letter ID UNITED-STATES RP BURKE, DS (reprint author), WALTER REED ARMY INST RES,ROCKVILLE,MD 20850, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD NOV 15 PY 1995 VL 123 IS 10 BP 812 EP 812 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA TE172 UT WOS:A1995TE17200027 PM 7574213 ER PT J AU Byrd, JC Edenfield, WJ Arthur, DC Lawrence, D Shah, D Trikha, E Weiss, RB Schiffer, CA Bloomfield, CD AF Byrd, JC Edenfield, WJ Arthur, DC Lawrence, D Shah, D Trikha, E Weiss, RB Schiffer, CA Bloomfield, CD TI Extramedullary leukemia (EML) is associated with pre-treatment cytogenetic abnormalities in patients with acute myeloid leukemia (AML): From CALGB 8461 SO BLOOD LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. CANC LEUKEMIA GRP B,CHICAGO,IL. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1995 VL 86 IS 10 SU 1 BP 161 EP 161 PG 1 WC Hematology SC Hematology GA TH910 UT WOS:A1995TH91000162 ER PT J AU Barker, JA Hartman, KR Edwards, EG LaRussa, VF AF Barker, JA Hartman, KR Edwards, EG LaRussa, VF TI Bone marrow stromal health predicts time to engraftment in autologous bone marrow transplant patients. SO BLOOD LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT HEMATOL,WASHINGTON,DC. WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1995 VL 86 IS 10 SU 1 BP 393 EP 393 PG 1 WC Hematology SC Hematology GA TH910 UT WOS:A1995TH91000395 ER PT J AU Krishnamurti, C Carter, AJ Maglasang, P Hess, J Alving, BM AF Krishnamurti, C Carter, AJ Maglasang, P Hess, J Alving, BM TI Cross-linked hemoglobin impairs cardiac function in endotoxin-treated rabbits. SO BLOOD LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1995 VL 86 IS 10 SU 1 BP 1766 EP 1766 PG 1 WC Hematology SC Hematology GA TH910 UT WOS:A1995TH91001768 ER PT J AU Hartman, KR Barker, JA AF Hartman, KR Barker, JA TI Congenital microcytic anemia with iron malabsorption: Effects of erythropoietin in vitro and in vivo. SO BLOOD LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV MED,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1995 VL 86 IS 10 SU 1 BP 1909 EP 1909 PG 1 WC Hematology SC Hematology GA TH910 UT WOS:A1995TH91001910 ER PT J AU Opal, SM Keith, JC Schaub, RG Palardy, J Parejo, N Jhung, J Bhattacharjee, A Young, L AF Opal, SM Keith, JC Schaub, RG Palardy, J Parejo, N Jhung, J Bhattacharjee, A Young, L TI Beneficial effects of recombinant human interleukin-11 (rhIL-11) in an experimental model of gram-negative sepsis in neutropenic animals. SO BLOOD LA English DT Meeting Abstract C1 BROWN UNIV,SCH MED,PROVIDENCE,RI 02912. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. GENET INST INC,CAMBRIDGE,MA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1995 VL 86 IS 10 SU 1 BP 1980 EP 1980 PG 1 WC Hematology SC Hematology GA TH910 UT WOS:A1995TH91001980 ER PT J AU Nath, J Powledge, A Gist, I Hartman, KR Smallridge, RC AF Nath, J Powledge, A Gist, I Hartman, KR Smallridge, RC TI Effect of alpha alpha-cross-linked hemoglobin on human neutrophil inflammatory responses: Studies in unprimed and endotoxin-primed cells. SO BLOOD LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DIV MED,WASHINGTON,DC. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1995 VL 86 IS 10 SU 1 BP 2011 EP 2011 PG 1 WC Hematology SC Hematology GA TH910 UT WOS:A1995TH91002011 ER PT J AU Greilich, PE Alving, BM ONeill, KL Chang, AS Reid, TJ AF Greilich, PE Alving, BM ONeill, KL Chang, AS Reid, TJ TI Modified thromboelastography: A rapid, simple method for monitoring c7E3 Fab in heparinized patients. SO BLOOD LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1995 VL 86 IS 10 SU 1 BP 2168 EP 2168 PG 1 WC Hematology SC Hematology GA TH910 UT WOS:A1995TH91002168 ER PT J AU Kark, JA Ward, FT Kim, WJ Gardner, JW AF Kark, JA Ward, FT Kim, WJ Gardner, JW TI Alpha-thalassemia protects against exertional mortality with sickle cell trait. SO BLOOD LA English DT Meeting Abstract C1 HOWARD UNIV,CTR SICKLE CELL DIS,WASHINGTON,DC 20059. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1995 VL 86 IS 10 SU 1 BP 2588 EP 2588 PG 1 WC Hematology SC Hematology GA TH910 UT WOS:A1995TH91002589 ER PT J AU Edenfield, WJ Byrd, JC Jones, MP Homoky, D Robson, M AF Edenfield, WJ Byrd, JC Jones, MP Homoky, D Robson, M TI Liver associated enzyme elevation and hepatic extramedullary hematopoiesis observed with granulocyte-colony stimulating factor (G-CSF) use in lymphoid malignancies. SO BLOOD LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1995 VL 86 IS 10 SU 1 BP 2754 EP 2754 PG 1 WC Hematology SC Hematology GA TH910 UT WOS:A1995TH91002755 ER PT J AU Reid, T LaRussa, V Esteban, G Hartman, K AF Reid, T LaRussa, V Esteban, G Hartman, K TI Effect of cryoprotectants and freezing on platelet induced clot retraction and platelet activation. SO BLOOD LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT HEMATOL ONCOL,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DEPT HEMATOL & VASC BIOL,WASHINGTON,DC. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1995 VL 86 IS 10 SU 1 BP 3429 EP 3429 PG 1 WC Hematology SC Hematology GA TH910 UT WOS:A1995TH91003430 ER PT J AU Aylesworth, CL Krishnamurti, C Peat, R Berg, L Tang, D Alving, BM AF Aylesworth, CL Krishnamurti, C Peat, R Berg, L Tang, D Alving, BM TI ELISA for detection of antibodies against the platelet factor 4 (PF4)/heparin complex: Methods for standardization. SO BLOOD LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1995 VL 86 IS 10 SU 1 BP 3446 EP 3446 PG 1 WC Hematology SC Hematology GA TH910 UT WOS:A1995TH91003447 ER PT J AU Christie, RJ Alving, BM AF Christie, RJ Alving, BM TI Management of coagulopathy in patients with antibodies against human factor V induced by bovine factor V in topical thrombin preparations. SO BLOOD LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,WASHINGTON,DC. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1995 VL 86 IS 10 SU 1 BP 3456 EP 3456 PG 1 WC Hematology SC Hematology GA TH910 UT WOS:A1995TH91003457 ER PT J AU Avery, R Reid, T AF Avery, R Reid, T TI Nitric oxide inhibits platelet contraction. SO BLOOD LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT HEMATOL ONCOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT HEMATOL & VASC BIOL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1995 VL 86 IS 10 SU 1 BP 3559 EP 3559 PG 1 WC Hematology SC Hematology GA TH910 UT WOS:A1995TH91003560 ER PT J AU Rothwell, SW Calvert, V AF Rothwell, SW Calvert, V TI Human platelets possess the molecular motors required for active organelle movement. SO BLOOD LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1995 VL 86 IS 10 SU 1 BP 3617 EP 3617 PG 1 WC Hematology SC Hematology GA TH910 UT WOS:A1995TH91003618 ER PT J AU Atkins, M Vukelja, S Corso, S McCarthy, M AF Atkins, M Vukelja, S Corso, S McCarthy, M TI Vitamin E in the treatment of high-dose chemotherapy-induced mucositis in autologous stem cell transplant patients SO BLOOD LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1995 VL 86 IS 10 SU 1 BP 3735 EP 3735 PG 1 WC Hematology SC Hematology GA TH910 UT WOS:A1995TH91003735 ER PT J AU BARTH, J AF BARTH, J TI THE FINANCIAL TIMES GLOBAL GUIDE TO INVESTING - THE SECRETS OF THE WORLDS LEADING INVESTMENT GURUS - MORTON,J SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD NOV 15 PY 1995 VL 120 IS 19 BP 85 EP 85 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA TE126 UT WOS:A1995TE12600129 ER PT J AU YARRISONRICE, JM SHARP, EJ WOOD, GL SALAMO, GJ KLANK, R NEURGAONKAR, RR AF YARRISONRICE, JM SHARP, EJ WOOD, GL SALAMO, GJ KLANK, R NEURGAONKAR, RR TI HIGH-RESOLUTION PHASE-CONJUGATE IMAGING IN DOUBLE-PUMPED PHASE CONJUGATORS SO APPLIED OPTICS LA English DT Article DE PHASE-CONJUGATE IMAGING; DOUBLE-PHASE CONJUGATION; PHOTOREFRACTION; HIGH SPATIAL RESOLUTION ID INCOHERENT BEAMS; MIRROR AB Phase-conjugate images with a resolution greater than 250 lines/mm are obtained through the use of a bridge, double-pumped phase conjugator. We demonstrate that this conjugator can carry out image-processing tasks, such as the addition and subtraction of complex spatial distributions, with a spatial resolution of > 100 lines/mm. These results represent a significant improvement over previously reported resolutions obtained from photorefractive mutually pumped phase conjugators and approach the theoretical limit imposed by the grating spacing and cross talk. (C) 1995 Optical Society of America C1 USA,RES LAB,FT BELVOIR,VA 22060. UNIV ARKANSAS,DEPT PHYS,FAYETTEVILLE,AR 72701. ROCKWELL INT CORP,CTR SERV,THOUSAND OAKS,CA 91360. RP YARRISONRICE, JM (reprint author), MIAMI UNIV,DEPT PHYS,OXFORD,OH 45056, USA. NR 23 TC 1 Z9 1 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD NOV 10 PY 1995 VL 34 IS 32 BP 7597 EP 7603 PG 7 WC Optics SC Optics GA TE198 UT WOS:A1995TE19800021 PM 21060637 ER PT J AU LIU, PLF CHO, YS BRIGGS, MJ KANOGLU, U SYNOLAKIS, CE AF LIU, PLF CHO, YS BRIGGS, MJ KANOGLU, U SYNOLAKIS, CE TI RUNUP OF SOLITARY WAVES ON A CIRCULAR ISLAND SO JOURNAL OF FLUID MECHANICS LA English DT Article AB This is a study of the interactions of solitary waves climbing up a circular island. A series of large-scale laboratory experiments with waves of different incident height-to-depth ratios and different crest lengths is described. Detailed two-dimensional run-up height measurements and time histories of surface elevations around the island are presented. A numerical model based on the two-dimensional shallow-water wave equations including runup calculations was developed. Numerical model predictions agreed very well with the laboratory data and the model was used to study wave trapping and the effect of slope. Under certain conditions, enhanced runup and wave trapping on the lee side of the island were observed, suggesting a possible explanation for the devastation reported by field surveys in Babi Island off Flores, Indonesia, and in Okushiri Island, Japan. C1 USA, ENGINEER WATERWAYS EXPT STN, COASTAL ENGN RES CTR, VICKSBURG, MS 39180 USA. UNIV SO CALIF, DEPT CIVIL ENGN, LOS ANGELES, CA 90089 USA. RP LIU, PLF (reprint author), CORNELL UNIV, SCH CIVIL & ENVIRONM ENGN, ITHACA, NY 14853 USA. RI Synolakis, Costas/B-3197-2008; Kanoglu, Utku/F-9037-2012; Liu, Philip/E-3619-2013; OI Synolakis, Costas/0000-0003-0140-5379; Kanoglu, Utku/0000-0002-5952-0954; Liu, Philip/0000-0002-2170-5507 NR 38 TC 226 Z9 231 U1 2 U2 25 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 40 WEST 20TH STREET, NEW YORK, NY 10011-4211 SN 0022-1120 J9 J FLUID MECH JI J. Fluid Mech. PD NOV 10 PY 1995 VL 302 BP 259 EP 285 DI 10.1017/S0022112095004095 PG 27 WC Mechanics; Physics, Fluids & Plasmas SC Mechanics; Physics GA TG213 UT WOS:A1995TG21300012 ER PT J AU QI, JX BOWMAN, JM MANAA, MR AF QI, JX BOWMAN, JM MANAA, MR TI AB-INITIO CHARACTERIZATION OF THE LOW-LYING VIBRATIONS OF HCO (DCO) IN THE (B)OVER-TILDE(2)A' STATE SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID SURFACE; FLUORESCENCE; SPECTROSCOPY; SPECTRA; SYSTEM AB We report a force field for HCO in the (B) over tilde (2)A' electronic state, based on ab initio electronic energies obtained using state-averaged multiconfiguration-self-consistent field/configuration interaction wave functions. The force field is used in rigorous calculations of 27 excited vibrational states of HCO and DCO, which are compared with experiment. A detailed analysis of the fundamentals of HCO and DCO suggests a reassignment of the experimental fundamentals of DCO is necessary. (C) 1995 American Institute of Physics. C1 EMORY UNIV,CHERRY L EMERSON CTR SCI COMP,ATLANTA,GA 30322. USA,RES LAB,AMSRL WT PC,ABERDEEN PROVING GROUND,MD 21005. RP QI, JX (reprint author), EMORY UNIV,DEPT CHEM,1515 PIERCE DR,ATLANTA,GA 30322, USA. NR 29 TC 4 Z9 4 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD NOV 8 PY 1995 VL 103 IS 18 BP 7664 EP 7672 DI 10.1063/1.470289 PG 9 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA TC854 UT WOS:A1995TC85400002 ER PT J AU COURTNEY, BC WILLIAMS, KC SCHLAGER, JJ AF COURTNEY, BC WILLIAMS, KC SCHLAGER, JJ TI A PHAGE DISPLAY VECTOR WITH IMPROVED STABILITY, APPLICABILITY AND EASE OF MANIPULATION SO GENE LA English DT Note DE PHAGEMID; FUSION PROTEIN; PEPTIDE LIBRARY AB We modified a combinatorial library display vector, pCOMB3, to provide a stable, easily manipulated, high-copy vector for the display of a random hexapeptide library. The propensity of the original phagemid to accumulate 800-1000-bp deletions in the region of the cloning site has been eliminated. Furthermore, the small 63-bp 'stuffer' at the cloning site was replaced with a 2114-bp DNA fragment from adenovirus 2. This produced a 5808-bp vector, that we have named pICD1LS, with the appropriate characteristics for single-peptide phage display. Libraries of greater than 10(6) molecules were produced with this vector. RP COURTNEY, BC (reprint author), USA,MED RES INST CHEM DEF,APPL PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 3 TC 12 Z9 13 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-1119 J9 GENE JI Gene PD NOV 7 PY 1995 VL 165 IS 1 BP 139 EP 140 DI 10.1016/0378-1119(95)00526-C PG 2 WC Genetics & Heredity SC Genetics & Heredity GA TF524 UT WOS:A1995TF52400025 PM 7489904 ER PT J AU FRYAUFF, DJ BAIRD, JK BASRI, H SUMAWINATA, I PURNOMO RICHIE, TL OHRT, CK MOUZIN, E CHURCH, CJ RICHARDS, AL SUBIANTO, B SANDJAJA, B WIGNALL, FS HOFFMAN, SL AF FRYAUFF, DJ BAIRD, JK BASRI, H SUMAWINATA, I PURNOMO RICHIE, TL OHRT, CK MOUZIN, E CHURCH, CJ RICHARDS, AL SUBIANTO, B SANDJAJA, B WIGNALL, FS HOFFMAN, SL TI RANDOMIZED PLACEBO-CONTROLLED TRIAL OF PRIMAQUINE FOR PROPHYLAXIS OF FALCIPARUM AND VIVAX MALARIA SO LANCET LA English DT Article ID CHLOROQUINE; PREVENTION AB Drug resistance has made malaria prevention difficult and the new agents are too expensive for widespread use, Primaquine, an established drug for treatment, is potentially useful for prevention, Malaria prophylaxis with primaquine was evaluated in Irian Jaya during one year in Javanese men who were not deficient in glucose-6-phosphate dehydrogenase (G-6-PD). 126 volunteers were randomised to receive 0 . 5 mg/hg primaquine base or placebo daily (double-blinded), or 300 mg chloroquine base weekly (open). The protective efficacy of primaquine relative to placebo was 94 . 5% (95% confidence interval 57-99) for Plasmodium falciparum and 90 . 4% (95% CI 58-98) for P vivax, Attack rates for either parasite did not differ significantly between the chloroquine and placebo groups. Incidence density of physical complaints not associated with parasitaemia was low (17-18 complaints/person-year) and was about the same in all groups except for cough, which was increased in the primaquine group. Complete blood counts were normal and no evidence of hepatic or renal dysfunction was found with primaquine. However, at 50 weeks the primaquine group had a mean methaemoglobin of 5 . 8% (range 1 . 4-13%), which declined by half within 7 days of ending prophylaxis. When used daily for one year by men with normal G-6-PD activity, primaquine was well tolerated and effective for prevention of malaria. C1 USN,MED RES UNIT 2,JAKARTA,INDONESIA. TULANE UNIV,MED CTR,DEPT MED,NEW ORLEANS,LA 70112. ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. PROV HLTH SERV,IRIAN JAYA,INDONESIA. USN,MED RES INST,BETHESDA,MD. NR 21 TC 112 Z9 113 U1 1 U2 4 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0099-5355 J9 LANCET JI Lancet PD NOV 4 PY 1995 VL 346 IS 8984 BP 1190 EP 1193 DI 10.1016/S0140-6736(95)92898-7 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA TC976 UT WOS:A1995TC97600008 PM 7475658 ER PT J AU ARTENSTEIN, AW COPPOLA, J BROWN, AE CARR, JK SANDERSBUELL, E GALBARINI, E MASCOLA, JR VANCOTT, TC SCHONBROOD, P MCCUTCHAN, FE BURKE, DS AF ARTENSTEIN, AW COPPOLA, J BROWN, AE CARR, JK SANDERSBUELL, E GALBARINI, E MASCOLA, JR VANCOTT, TC SCHONBROOD, P MCCUTCHAN, FE BURKE, DS TI MULTIPLE INTRODUCTIONS OF HIV-1 SUBTYPE-E INTO THE WESTERN-HEMISPHERE SO LANCET LA English DT Note AB There are nine recognised genetic subtypes of HIV-1, and the epidemic in Southeast Asia is largely due to subtype E. We have investigated HIV-1 viral subtypes in 11 Uruguayan military personnel, six with infection acquired during a United Nations deployment to Cambodia and five with infection acquired in South America. We found subtype E in five of the six infections acquired in Southeast Asia, and subtype B in all five of the domestically acquired cases. These findings document multiple introductions of HIV-1 subtype E into the western hemisphere and mean that the genetic diversity of the global HIV-1 pandemic must be considered in strategies for epidemic control. C1 NATL HLTH DIRECTORATE ARMED FORCES,MONTEVIDEO,URUGUAY. HENRY M JACKSON FDN,ROCKVILLE,MD. RP ARTENSTEIN, AW (reprint author), WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 NR 10 TC 75 Z9 75 U1 0 U2 0 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0099-5355 J9 LANCET JI Lancet PD NOV 4 PY 1995 VL 346 IS 8984 BP 1197 EP 1198 DI 10.1016/S0140-6736(95)92900-2 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA TC976 UT WOS:A1995TC97600010 PM 7475660 ER PT J AU BRODINE, SK MASCOLA, JR WEISS, PJ ITO, SI PORTER, KR ARTENSTEIN, AW GARLAND, FC MCCUTCHAN, FE BURKE, DS AF BRODINE, SK MASCOLA, JR WEISS, PJ ITO, SI PORTER, KR ARTENSTEIN, AW GARLAND, FC MCCUTCHAN, FE BURKE, DS TI DETECTION OF DIVERSE HIV-1 GENETIC SUBTYPES IN THE USA SO LANCET LA English DT Note AB Of the nine genetic subtypes of HIV-1 that exist world wide, subtype B predominates in North America and Europe. Thus, most knowledge about HIV-1 and most vaccine development efforts are based on subtype B viruses. We document here the detection of HIV-1 subtypes A, D, and E in five US servicemen who acquired these non-subtype-B infections during overseas deployments. The dispersal of diverse HIV-1 subtypes into regions of the world with previously restricted genetic diversity may have important implications for the epidemiology of the epidemic and for the design and implementation of vaccine trials. C1 USN,MED RES INST,DEPT INFECT DIS,BETHESDA,MD. WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD. USN,MED CTR,DEPT INTERNAL MED,DIV INFECT DIS,SAN DIEGO,CA 92152. HENRY M JACKSON FDN,ROCKVILLE,MD. RP BRODINE, SK (reprint author), USN,HLTH RES CTR,DIV CLIN EPIDEMIOL,DEPT HLTH SCI & EPIDEMIOL,SAN DIEGO,CA 92186, USA. OI /0000-0002-5704-8094 NR 10 TC 123 Z9 123 U1 0 U2 1 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0099-5355 J9 LANCET JI Lancet PD NOV 4 PY 1995 VL 346 IS 8984 BP 1198 EP 1199 DI 10.1016/S0140-6736(95)92901-0 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA TC976 UT WOS:A1995TC97600011 PM 7475661 ER PT J AU LEWIS, RP TAHA, HA AF LEWIS, RP TAHA, HA TI AN INVESTIGATION OF THE USE OF GOAL PROGRAMMING TO FIT RESPONSE SURFACES SO EUROPEAN JOURNAL OF OPERATIONAL RESEARCH LA English DT Article ID REGRESSION AB This paper deals with the development and implementation of goal programming models for fitting response surfaces where the observed data are characterized by certain peculiarities, such as the existence of 'outliers'. A factorial statistical experiment is designed to compare (through Multivariate ANOVA) various forms of the goal programming algorithm with the traditional ordinary least squares method. The comparison is based on both the speed of convergence of the proposed algorithms and the accuracy of the estimated optimum solution relative to the true optimum of a pre-specified theoretical response surface. Results indicate that two different goal programming methods - each involving two secondary criteria - achieved a more accurate estimated solution than did the ordinary least squares method. This advantage is realized at the expense of slower convergence speed, however. C1 UNIV ARKANSAS,FAYETTEVILLE,AR 72701. USA,SCH ENGN & LOGIST,WASHINGTON,DC 20310. NR 24 TC 4 Z9 4 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0377-2217 J9 EUR J OPER RES JI Eur. J. Oper. Res. PD NOV 2 PY 1995 VL 86 IS 3 BP 537 EP 548 DI 10.1016/0377-2217(94)00065-K PG 12 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA RX952 UT WOS:A1995RX95200011 ER PT J AU HOLT, SE AF HOLT, SE TI RIGHT MIDDLE FINGER PAIN SO ACADEMIC EMERGENCY MEDICINE LA English DT Article C1 BROOKE ARMY MED CTR,JOINT MIL MED CTR,EMERGENCY MED RESIDENCY,SAN ANTONIO,TX. NR 7 TC 0 Z9 0 U1 0 U2 0 PU HANLEY & BELFUS INC PI PHILADELPHIA PA 210 S 13TH ST, PHILADELPHIA, PA 19107 SN 1069-6563 J9 ACAD EMERG MED JI Acad. Emerg. Med. PD NOV PY 1995 VL 2 IS 11 BP 988 EP & DI 10.1111/j.1553-2712.1995.tb03127.x PG 0 WC Emergency Medicine SC Emergency Medicine GA TB338 UT WOS:A1995TB33800011 PM 8536126 ER PT J AU Mather, B AF Mather, B TI Influence of organic admixtures and testing method on freeze-thaw resistance of concrete. SO ACI MATERIALS JOURNAL LA English DT Discussion C1 USA,WATERWAYS EXPLORAT STN,STRUCT LAB,VICKSBURG,MS. RP Mather, B (reprint author), AMER CONCRETE INST,DETROIT,MI 48219, USA. NR 4 TC 0 Z9 0 U1 0 U2 1 PU AMER CONCRETE INST PI FARMINGTON HILLS PA 38800 INTERNATIONAL WAY, COUNTRY CLUB DRIVE, PO BOX 9094, FARMINGTON HILLS, MI 48333-9094 SN 0889-325X J9 ACI MATER J JI ACI Mater. J. PD NOV-DEC PY 1995 VL 92 IS 6 BP 699 EP 699 PG 1 WC Construction & Building Technology; Materials Science, Multidisciplinary SC Construction & Building Technology; Materials Science GA TQ003 UT WOS:A1995TQ00300015 ER PT J AU MARTIN, DD WINTERS, DR MOHR, AJ HARPER, BG AF MARTIN, DD WINTERS, DR MOHR, AJ HARPER, BG TI CHARACTERIZATION OF AEROSOLIZED OVALBUMIN SO AEROSOL SCIENCE AND TECHNOLOGY LA English DT Article AB Aerosol stability of ovalbumin at various environmental conditions was examined in terms of aerodynamic particle size/mass, particle concentration, and detection by enzyme-linked immunosorbent assay (ELISA). Aerosols of ovalbumin were generated in a 1000 liter dynamic aerosol toroid (DAT) drum and the aerosol was sampled over a two hour period with all-glass impingers (AGIs) and an aerodynamic particle sizer (APS(R)). Aerodynamic size and mass increases, associated with increases in temperature and relative humidity, were shown to be small but statistically significant (P less than or equal to 0.0014). A minimum of 50% of the aerosolized ovalbumin was detectable by ELISA after 2 h under all conditions tested. The stability of ovalbumin as demonstrated would allow it to be used as an aerosolized protein challenge material in biological defense testing under the temperature and humidity conditions tested. RP MARTIN, DD (reprint author), USA,DUGWAY PROVING GROUND,W DESERT TEST CTR,DIV LIFE SCI,DUGWAY PROVING GROUND,UT 84022, USA. NR 6 TC 1 Z9 1 U1 1 U2 1 PU ELSEVIER SCIENCE PUBL CO INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0278-6826 J9 AEROSOL SCI TECH JI Aerosol Sci. Technol. PD NOV PY 1995 VL 23 IS 4 BP 534 EP 540 DI 10.1080/02786829508965335 PG 7 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA TJ874 UT WOS:A1995TJ87400005 ER PT J AU PINNICK, RG HILL, SC NACHMAN, P PENDLETON, JD FERNANDEZ, GL MAYO, MW BRUNO, JG AF PINNICK, RG HILL, SC NACHMAN, P PENDLETON, JD FERNANDEZ, GL MAYO, MW BRUNO, JG TI FLUORESCENCE PARTICLE COUNTER FOR DETECTING AIRBORNE BACTERIA AND OTHER BIOLOGICAL PARTICLES SO AEROSOL SCIENCE AND TECHNOLOGY LA English DT Article ID PROTEIN TRYPTOPHAN FLUORESCENCE; STEADY-STATE; DECAY CHARACTERISTICS; UNITED-STATES; AEROSOL; DISTRIBUTIONS; SCATTERING AB We have constructed a laser-based particle counter that detects the fluorescence, as well as the elastic scattering, from individual airborne particles as they traverse a laser beam. This fluorescence particle counter (FPC) can detect fluorescence from mu m-sized Bacillus subtilis spore agglomerates when illuminated with intense light at 488 nm from an argon ion laser, either similar to 0.7 kW cm(-2) extracavity or similar to 50 kW cm(-2) intracavity. We suspect that flavins in the spores are the molecules primarily responsible for the fluorescence, because the peak fluorescence emission of the biological materials at this excitation wavelength is in the range 530-550 nm, which is characteristic of flavins. Fluorescence form kaolin, hematite, and polystyrene particles was not detectable, the lack of fluorescence indicates that the FPC may be able to differentiate between biological and nonbiological aerosols. The FPC samples aerosol-laden air at a rate of similar to 1 mL s(-1), and is capable of measuring aerosol concentrations up to several thousand per milliliter. The FPC may be helpful in detecting and characterizing airborne bacteria and other airborne particles of biological origin. C1 NEW MEXICO STATE UNIV,DEPT PHYS,LAS CRUCES,NM 88003. USAF,ARMSTRONG LAB,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. RP PINNICK, RG (reprint author), USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 39 TC 83 Z9 84 U1 3 U2 13 PU ELSEVIER SCIENCE PUBL CO INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0278-6826 J9 AEROSOL SCI TECH JI Aerosol Sci. Technol. PD NOV PY 1995 VL 23 IS 4 BP 653 EP 664 DI 10.1080/02786829508965345 PG 12 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA TJ874 UT WOS:A1995TJ87400015 ER PT J AU VANCOTT, TC POLONIS, VR LOOMIS, LD MICHAEL, NL NARA, PL BIRX, DL AF VANCOTT, TC POLONIS, VR LOOMIS, LD MICHAEL, NL NARA, PL BIRX, DL TI DIFFERENTIAL ROLE OF V3-SPECIFIC ANTIBODIES IN NEUTRALIZATION ASSAYS INVOLVING PRIMARY AND LABORATORY-ADAPTED ISOLATES OF HIV TYPE-1 SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; HUMAN MONOCLONAL-ANTIBODY; BIOSPECIFIC INTERACTION ANALYSIS; ENVELOPE GLYCOPROTEIN; ACID SEQUENCE; AIDS VIRUS; GP120; INFECTION; EPITOPE; PEPTIDE AB To identify epitopes important in neutralizing primary HIV-1 isolates, we have selectively depleted HIV-1 sera of antibodies specific for the third hypervariable region (V3) of the HIV-1 envelope glycoprotein gp120, and then assessed the functional consequences of such depletion in neutralization assays. The nucleotide sequence of the V3 loop region from HIV-1 PBMC DNA was determined for three HIV-1-infected patients, corresponding peptides were synthesized, and then subsequently used for V3 depletion of the patient sera. Depletion using a single clade B V3 peptide was capable of depleting > 98% of binding antibodies to multiple clade B V3 peptides, including those with changes within the GPG (X) under bar tip of the loop. Depleted and undepleted sera were studied for their ability to neutralize both laboratory-adapted HIV-1(MN) and two primary HIV-1 isolates with known V3 sequences, using a viral infectivity reduction assay. While the majority of HIV-1(MN) neutralization was lost on V3 depletion, the loss in neutralization capacity against primary isolates by these same V3-depleted sera was substantially less pronounced. This suggests that V3 peptide-specific antibodies within HIV-1 serum play a fundamentally different role in mediating neutralization in assays involving laboratory-adapted and primary isolates and implicates antibodies with epitope specificities outside of V3 as major determinants in neutralization assays involving primary isolates. C1 SRA TECHNOL,SHADY GROVE,MD 20850. HENRY M JACKSON FDN,ROCKVILLE,MD 20850. NCI,FREDERICK CANC RES & DEV CTR,TUMOR CELL BIOL LAB,FREDERICK,MD 21702. RP VANCOTT, TC (reprint author), WALTER REED ARMY INST RES,DIV RETROVIROL,13 TAFT CT,SUITE 200,ROCKVILLE,MD 20850, USA. NR 62 TC 95 Z9 95 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV PY 1995 VL 11 IS 11 BP 1379 EP 1391 DI 10.1089/aid.1995.11.1379 PG 13 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA TG264 UT WOS:A1995TG26400009 PM 8573396 ER PT J AU SALMINEN, MO CARR, JK BURKE, DS MCCUTCHAN, FE AF SALMINEN, MO CARR, JK BURKE, DS MCCUTCHAN, FE TI IDENTIFICATION OF BREAKPOINTS IN INTERGENOTYPIC RECOMBINANTS OF HIV TYPE-1 BY BOOTSCANNING SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Note C1 WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD 20850. RP SALMINEN, MO (reprint author), HENRY M JACKSON FDN ADV MIL MED,1600 E GUDE DR,ROCKVILLE,MD 20850, USA. RI Salminen, Mika/D-8784-2013; OI Salminen, Mika/0000-0003-3020-0866; /0000-0002-5704-8094 NR 11 TC 524 Z9 539 U1 0 U2 5 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV PY 1995 VL 11 IS 11 BP 1423 EP 1425 DI 10.1089/aid.1995.11.1423 PG 3 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA TG264 UT WOS:A1995TG26400016 PM 8573403 ER PT J AU TRIPPEL, DL PARSONS, MK GILLETTE, PC AF TRIPPEL, DL PARSONS, MK GILLETTE, PC TI INFANTS WITH LONG-QT SYNDROME AND 2/1 ATRIOVENTRICULAR-BLOCK SO AMERICAN HEART JOURNAL LA English DT Note ID CONDUCTION SYSTEM DISEASE; PROLONGED QT; INTERVAL; CHILDHOOD; CHILDREN; NEWBORN; DEATH C1 TRIPLER ARMY MED CTR, HONOLULU, HI 96859 USA. RP TRIPPEL, DL (reprint author), CHILDRENS HOSP KINGS DAUGHTERS, DIV PEDIAT CARDIOL, 601 CHILDRENS LN, NORFOLK, VA 23507 USA. NR 21 TC 61 Z9 63 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-8703 EI 1097-5330 J9 AM HEART J JI Am. Heart J. PD NOV PY 1995 VL 130 IS 5 BP 1130 EP 1134 DI 10.1016/0002-8703(95)90222-8 PG 5 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA TC808 UT WOS:A1995TC80800032 PM 7484750 ER PT J AU GRABENSTEIN, JD AF GRABENSTEIN, JD TI THE SAFETY AND HAZARDS OF BLOOD-DERIVED DRUGS SO AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY LA English DT Editorial Material RP GRABENSTEIN, JD (reprint author), USA,MED DEPT CTR & SCH,MCCS-GCL,1608 STANLEY RD,FT SAM HOUSTON,TX 78234, USA. NR 29 TC 3 Z9 3 U1 0 U2 0 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 SN 1079-2082 J9 AM J HEALTH-SYST PH JI Am. J. Health-Syst. Pharm. PD NOV 1 PY 1995 VL 52 IS 21 BP 2448 EP 2452 PG 5 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA TC510 UT WOS:A1995TC51000016 PM 8564613 ER PT J AU AYLESWORTH, CA SMALLRIDGE, RC RICK, ME ALVING, BM AF AYLESWORTH, CA SMALLRIDGE, RC RICK, ME ALVING, BM TI ACQUIRED VON WILLEBRANDS DISEASE - A RARE MANIFESTATION OF POSTPARTUM THYROIDITIS SO AMERICAN JOURNAL OF HEMATOLOGY LA English DT Note DE VON WILLEBRANDS DISEASE; HYPOTHYROIDISM; POSTPARTUM THYROIDITIS ID VONWILLEBRANDS DISEASE; HYPOTHYROIDISM AB This report describes the diagnosis of acquired type I von Willebrand disease in a 30-year-old woman (G(5)P(5)) who presented with complaints of excessive bleeding in the postpartum period. The patient's additional complaints of fatigue, depression, and inability to lose weight resulted in laboratory testing that indicated hypothyroidism due to thyroiditis. Clinical symptoms and laboratory tests for von Willebrand disease and hypothyroidism normalized with L-thyroxine replacement, Thyroiditis resulting in symptomatic hypothyroidism occurs in 2-4 per cent of postpartum women. The possibility of underlying hypothyroidism should be considered for those patients, especially if they are parous women, who appear to have an acquired bleeding disorder suggestive of von Willebrand disease. (C) 1995 Wiley-Liss, Inc.* C1 WALTER REED ARMY MED CTR,DEPT HEMATOL ONCOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT HEMATOL & VASC BIOL,WASHINGTON,DC 20307. NIH,CTR CLIN,DEPT HEMATOL,BETHESDA,MD 20892. NR 10 TC 19 Z9 20 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0361-8609 J9 AM J HEMATOL JI Am. J. Hematol. PD NOV PY 1995 VL 50 IS 3 BP 217 EP 219 DI 10.1002/ajh.2830500311 PG 3 WC Hematology SC Hematology GA TB942 UT WOS:A1995TB94200010 PM 7485084 ER PT J AU PICKETT, BP CAIL, WS LAMBERT, PR AF PICKETT, BP CAIL, WS LAMBERT, PR TI SINUS TYMPANI - ANATOMIC CONSIDERATIONS, COMPUTED-TOMOGRAPHY, AND A DISCUSSION OF THE RETROFACIAL APPROACH FOR REMOVAL OF DISEASE SO AMERICAN JOURNAL OF OTOLOGY LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Otological-Society CY MAY 07-08, 1994 CL PALM BEACH, FL SP Amer Otol Soc AB Surgical access to the sinus tympani remains a challenge for otologic surgeons. Usually, the retrotympanum is approached through the middle ear in an anterior to posterior direction during chronic ear surgery. Whether this is via a posterior tympanotomy or after canal wall down tympanomastoidectomy, visualization of the most posterior recess of the sinus tympani is often inadequate. The purpose of this investigation is two fold: (1) to describe the highly variable anatomy of the posterior tympanic cavity and (2) to review the retrofacial approach to the sinus tympani. Histologic sections, cadaver dissections, and diagrammatic illustrations are combined with computed tomographic (CT) imaging to provide a three-dimensional understanding of the sinus tympani and adjacent labyrinthine structures. Viewed from the mastoid, the anatomic structures that define the boundaries of the retrofacial approach include the facial nerve and stapedius muscle laterally, the lateral semicircular canal superiorly, the posterior semicircular canal posteromedially, the vestibule anteromedially, and the jugular bulb inferiorly. When the sinus tympani is well developed, saucerization within these boundaries gives wide access into the sinus and round window niche. The authors suggest that preoperative imaging can select patients who are candidates for a retrofacial approach to expose and remove disease in the sinus tympani. Contraindications to this approach include axial CT image measurements showing a contracted space between the posterior semicircular canal and the medial aspect of the facial nerve, lack of posterior expansion of the sinus tympani, and in cases where these measurements are marginal, the presence of a high jugular bulb or anteriorly positioned sigmoid sinus. C1 UNIV VIRGINIA,HLTH SCI CTR,DEPT RADIOL,DIV NEURORADIOL,CHARLOTTESVILLE,VA 22908. UNIV VIRGINIA,HLTH SCI CTR,DEPT OTOLARYNGOL HEAD & NECK SURG,DIV OTOL NEUROTOL,CHARLOTTESVILLE,VA. RP PICKETT, BP (reprint author), WALTER REED ARMY MED CTR,DIV OTOL NEUROTOL,OTOLARYNGOL HEAD & NECK SURG SERV,WASHINGTON,DC 20307, USA. NR 19 TC 23 Z9 25 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0192-9763 J9 AM J OTOL JI Am. J. Otol. PD NOV PY 1995 VL 16 IS 6 BP 741 EP 750 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA TD815 UT WOS:A1995TD81500007 PM 8572136 ER PT J AU LEVIN, LI PETERMAN, TA RENZULLO, PO LASLEYBIBBS, V SHU, XO BRUNDAGE, JF MCNEIL, JG AF LEVIN, LI PETERMAN, TA RENZULLO, PO LASLEYBIBBS, V SHU, XO BRUNDAGE, JF MCNEIL, JG TI HIV-1 SEROCONVERSION AND RISK BEHAVIORS AMONG YOUNG MEN IN THE US ARMY SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; UNITED-STATES-ARMY; NEW-YORK-CITY; HOMOSEXUAL MEN; CIVILIAN APPLICANTS; MILITARY SERVICE; OCTOBER 1985; CONDOM USE; INFECTION; AIDS AB Objectives. This study sought to examine risk factors associated with human immunodeficiency virus type 1 (HIV-1) seroconversion among active-duty men in the US Army. Methods. One hundred twenty-eight men with documented HIV-1 seroconversion between 1988 and 1991 were matched to control subjects on demographic variables. Risk factor information was collected for the seroconversion period. Results. Forty-nine case subjects and no control subjects reported same-gender sex; this includes 34 case subjects who also reported sex with women. Seventy case and 118 control subjects reported no risk factors other than heterosexual intercourse. Among heterosexuals, excess risk was noted for men who had sex with women in risk categories-defined by the Centers for Disease Control and Prevention (odds ratio = 10.0; 95% confidence interval = 1.3, 78.1). Significant trends of increasing risk for seroconversion were found with increasing numbers of female partners, nonsteady partners, and partners with whom sex occurred on the first day of acquaintance. Conclusions In this population. the major risk factor for HIV-1 seroconversion was same-gender sex. Among heterosexuals, sex with anonymous or casual partners increased this risk. Intervention programs should emphasize the risk of indiscriminate partner selection in addition to ''safe sex'' practices. C1 CTR DIS CONTROL & PREVENT,CTR PREVENT SERV,DIV SEXUALLY TRANSMITTED DIS,ATLANTA,GA. UNIV MINNESOTA,SCH MED,DEPT PEDIAT,MINNEAPOLIS,MN 55455. RP LEVIN, LI (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV PREVENT MED,WASHINGTON,DC 20307, USA. NR 29 TC 20 Z9 20 U1 1 U2 2 PU AMER PUBLIC HEALTH ASSN INC PI WASHINGTON PA 1015 FIFTEENTH ST NW, WASHINGTON, DC 20005 SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD NOV PY 1995 VL 85 IS 11 BP 1500 EP 1506 DI 10.2105/AJPH.85.11.1500 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA TB493 UT WOS:A1995TB49300006 PM 7485661 ER PT J AU HEALY, JT WILKINSON, NW SAWYER, M AF HEALY, JT WILKINSON, NW SAWYER, M TI ABDOMINAL-WALL ENDOMETRIOMA IN A LAPAROSCOPIC TROCAR TRACT - A CASE-REPORT SO AMERICAN SURGEON LA English DT Note AB Extrapelvic endometriosis often presents as an atypical, painful abdominal mass often referred to the surgeon for diagnosis and treatment. The majority of extrapelvic endometriosis is found in surgical scars. We present a patient with an abdominal wall endometrioma that occurred in a laparoscopy trocar tract. To our knowledge, this is the first such case reported in the surgery or gynecology literature. With the increasing use of laparoscopy for gynecologic and general surgery procedures, this problem will likely become more common. The general surgeon should know how to diagnose and treat endometriomas arising in laparoscopic trocar tracts. RP HEALY, JT (reprint author), TRIPLER ARMY MED CTR,DEPT GEN SURG,HONOLULU,HI 96859, USA. NR 5 TC 38 Z9 44 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI ATLANTA PA 1776 PEACHTREE RD, NW., SUITE 410N, ATLANTA, GA 30309-2352 SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD NOV PY 1995 VL 61 IS 11 BP 962 EP 963 PG 2 WC Surgery SC Surgery GA TA745 UT WOS:A1995TA74500009 PM 7486427 ER PT J AU MONGAN, PD HINMAN, JA AF MONGAN, PD HINMAN, JA TI EVALUATION OF A DOUBLE-LUMEN MULTIORIFICE CATHETER FOR RESUSCITATION OF SWINE FROM LETHAL VENOUS AIR-EMBOLISM SO ANESTHESIOLOGY LA English DT Article DE CATHETERIZATION, CENTRAL VENOUS, INSTRUMENTATION; EMBOLISM, AIR, THERAPY; RESUSCITATION, METHODS ID SITTING POSITION; PULMONARY-ARTERY; DOGS; RETRIEVAL AB Background: A double-lumen multiorifice catheter has been developed to potentially enhance accurate electrocardiographic central venous localization and resuscitation from a massive venous air embolism (VAE). This double-lumen multiorifice catheter was compared to a Bunegin-Albin multiorifice catheter for flow characteristics, air aspiration efficiency, and efficacy in resuscitating swine from a lethal VAE. Methods: Flow characteristics of both catheters were determined by aspirating both agitated and unagitated citrated swine blood with a 50-ml syringe. Swine were anesthetized with halothane and positioned to approximate a modified sitting craniotomy position (45-degree elevation), By a random block method, 24 swine were assigned to either catheter (n = 12 each catheter) for the initial air aspiration. Catheters were positioned, using intravenous electrocardiography, with the distal aspiration orifice in the high right atrium. A 5-ml/kg air embolism was administered over 30 s into the sagittal sinus, and the swine were resuscitated by aspirating air through the multiorifice catheters and then positioning the swine horizontally, Surviving animals were allowed to recover for 60 min. The initial catheter was exchanged and repositioned in the high right atrium using intravenous electrocardiography. A 5-ml/kg air embolus was administered, and the swine were resuscitated as in the first challenge, Surviving swine recovered for 60 min, repositioned, and administered a third 5-ml/kg air embolism, On this final challenge, no attempt was made to resuscitate the animal by aspirating the multiorifice catheter. Results: Flow characteristics of both catheters were similar in the unagitated blood (195.3 +/- 1.9 v,s. 196.7 +/- 2.5 ml/min). The Bow rate of agitated blood through the double-lumen multiorifice catheter was 14% greater than through the Bunegin-Albin catheter (136.3 +/- 6.8 vs. 117 +/- 5.9 m//min, P = 0.001). Forty-three air embolism trials were conducted at 5 ml/kg. All nine trials at 5 ml/kg without air aspiration resulted in death. Five animals died during the embolism dose determination trials, and four died during the third embolism challenge. The use of a multiorifice catheter for aspiration after a VAE enhanced survival after a 5-ml/kg sagittal sinus air embolus (14/34 vs. 0/9, P = 0.02), Although the double-lumen multiorifice catheter was more efficient than the Bunegin-Albin catheter in percentage of air retrieved (37.7 +/- 12.0 vs. 29.7 +/- 10.1, P = 0.042). Aspiration of the VAE with the double-lumen multiorifice catheter successfully rescued 9 of the 15 trials, and aspiration using the Bunegin-Albin catheter resuscitated 5 of the 19 (P = 0.08), Conclusions: Multiorifice catheters are effective in resuscitating swine from a lethal VAE. The double-lumen multiorifice catheter evaluated aspirated a larger percentage of the VAE but was not statistically more effective than the Bunegin-Albin catheter in resuscitating the animals. Based on these findings of improved flow rate and efficiency in air aspiration, further investigation of this double-lumen multiorifice catheter is warranted. RP MONGAN, PD (reprint author), BROOKE ARMY MED CTR,DEPT SURG,ANESTHESIA & OPERAT SERV,SAN ANTONIO,TX 78234, USA. NR 17 TC 8 Z9 9 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD NOV PY 1995 VL 83 IS 5 BP 1104 EP 1111 DI 10.1097/00000542-199511000-00025 PG 8 WC Anesthesiology SC Anesthesiology GA TD723 UT WOS:A1995TD72300026 PM 7486162 ER PT J AU LEUNG, JM AF LEUNG, JM TI ROLE OF EPIDURAL-ANESTHESIA AND ANALGESIA ON POSTOPERATIVE-PATIENT OUTCOME SO ANESTHESIOLOGY LA English DT Letter RP LEUNG, JM (reprint author), UNIFORMED SERV UNIV HLTH SCI,WALTER REED ARMY MED CTR,DEPT ANESTHESIOL,WASHINGTON,DC 20307, USA. NR 2 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD NOV PY 1995 VL 83 IS 5 BP 1132 EP 1133 DI 10.1097/00000542-199511000-00034 PG 2 WC Anesthesiology SC Anesthesiology GA TD723 UT WOS:A1995TD72300036 PM 7486171 ER PT J AU STEVANOVIC, M WODICKA, GR BOURLAND, JD GRABER, GP FOSTER, KS LANTZ, GC TACKER, WA CYMERMAN, A AF STEVANOVIC, M WODICKA, GR BOURLAND, JD GRABER, GP FOSTER, KS LANTZ, GC TACKER, WA CYMERMAN, A TI THE EFFECT OF ELEVATED INTRACRANIAL-PRESSURE ON THE VIBRATIONAL RESPONSE OF THE OVINE HEAD SO ANNALS OF BIOMEDICAL ENGINEERING LA English DT Article DE INTRACRANIAL PRESSURE; SOUND; VIBRATION; SHEEP ID POINT IMPEDANCE AB Although potentially fatal increases in intracranial pressure (ICP) can occur in a number of pathological conditions, there is no reliable and noninvasive procedure to detect ICP elevation and quantitatively monitor changes over time. In this experimental study, the relationships between ICP elevation and the vibrational response of the head were determined. An ovine animal model was employed in which incremental increases in ICP were elicited and directly measured through intraventricular cannulae. At each ICP increment, a vibration source elicited a flexural response of the animal's head that was measured at four locations on the skull using accelerometers. Spectral analysis of the responses showed changes in proportion to ICP change up to roughly 20 cm H2O (15 mm Hg) above normal; a clinically significant range. Both magnitude and phase changes at frequencies between 4 and 7 kHz correlated well (gamma > 0.92) with ICP across the study group. These findings suggest that the vibrational response of the head can be used to monitor changes in ICP noninvasively. C1 PURDUE UNIV,HILLENBRAND BIOMED ENGN CTR,W LAFAYETTE,IN 47907. PURDUE UNIV,SCH ELECT & COMP ENGN,W LAFAYETTE,IN 47907. PURDUE UNIV,SCH VET MED,W LAFAYETTE,IN 47907. USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 14 TC 3 Z9 3 U1 0 U2 3 PU BLACKWELL SCIENCE PUBL INC CAMBRIDGE PI CAMBRIDGE PA 238 MAIN ST, CAMBRIDGE, MA 02142 SN 0090-6964 J9 ANN BIOMED ENG JI Ann. Biomed. Eng. PD NOV-DEC PY 1995 VL 23 IS 6 BP 720 EP 727 DI 10.1007/BF02584471 PG 8 WC Engineering, Biomedical SC Engineering GA TE841 UT WOS:A1995TE84100002 PM 8572422 ER PT J AU GAMBLE, WB MANSON, PN SMITH, GE HAMRA, ST AF GAMBLE, WB MANSON, PN SMITH, GE HAMRA, ST TI COMPARISON OF SKIN-TISSUE TENSIONS USING THE COMPOSITE AND THE SUBCUTANEOUS RHYTIDECTOMY TECHNIQUES SO ANNALS OF PLASTIC SURGERY LA English DT Article ID FACELIFT AB Controversy as to benefits, risks, and long-term durability of the subcutaneous rhytidectomy as compared with the composite and the subcutaneous musculoaponeurotic system (SMAS) rhytidectomy procedures has persisted over the last several years. Conventional surgical wisdom holds that deep-tissue support would provide both immediate and long-term benefits in rhytidectomy patients. Recent investigations have shown that deep-tissue support using the SMAS technique decreases epidermis closure tension. This effect has potential implications on vascularity, healing, scar formation, duration of results, and tension-related trophic changes. Twelve fresh frozen cadavers were dissected. At random, one side was treated with the composite technique as described by Hamra, whereas the other was treated with a standard subcutaneous rhytidectomy without SMAS intervention. Using this approach, variability between techniques could be more accurately compared. Dissection levels were made as identical as possible on both sides. Tensions were then measured from premarked, standard key points, evaluating (1) the amount of tension required to move the point 2 cm; (2) with a pull of 1.00 kg, the amount of skin that could then be excised; and (3) after securing the composite 2.0 cm reference points using deep-tissue support sutures, the amount of tension needed to advance the skin to closure. We found that the composite method has a higher resistance to stretch than the subcutaneous method, which translates into a lesser amount of skin excision possible at a given tension. The added resistance is most likely the result of the deep fibromuscular layer. Resistance could be overcome by placement of deep support sutures, and the effect of the fibromuscular layer (SMAS) is effectively neutralized through increased viscoelastic support. This effect potentially helps to protect the dermal plexuses from the effects of tension created using the composite technique. The tension necessary to advance the epidermis to closure therefore compares favorably to the subcutaneous rhytidectomy method. C1 WALTER REED ARMY MED CTR,PLAST & RECONSTRUCT SURG SERV,WASHINGTON,DC 20307. JOHNS HOPKINS MED INST,DIV PLAST & RECONSTRUCT SURG,BALTIMORE,MD 21205. NR 12 TC 9 Z9 9 U1 0 U2 1 PU LITTLE BROWN CO PI BOSTON PA 34 BEACON STREET, BOSTON, MA 02108-1493 SN 0148-7043 J9 ANN PLAS SURG JI Ann. Plast. Surg. PD NOV PY 1995 VL 35 IS 5 BP 447 EP 453 DI 10.1097/00000637-199511000-00001 PG 7 WC Surgery SC Surgery GA TF257 UT WOS:A1995TF25700001 PM 8579260 ER PT J AU STRICKMAN, D SHEER, T SALATA, K HERSHEY, J DASCH, G KELLY, D KUSCHNER, R AF STRICKMAN, D SHEER, T SALATA, K HERSHEY, J DASCH, G KELLY, D KUSCHNER, R TI IN-VITRO EFFECTIVENESS OF AZITHROMYCIN AGAINST DOXYCYCLINE-RESISTANT AND DOXYCYCLINE-SUSCEPTIBLE STRAINS OF RICKETTSIA-TSUTSUGAMUSHI, ETIOLOGIC AGENT OF SCRUB TYPHUS SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article AB In an effort to find a potential alternative treatment for scrub typhus, we evaluated the effectiveness of the standard drug doxycycline and the new macrolide azithromycin against a doxycycline-susceptible strain (Karp) and a doxycycline-resistant strain (AFSC-4) of Rickettsia tsutsugamushi, The antibiotics were tested in an in vitro assay system in which infected mouse fibroblast cells (L929) were incubated for 3 days in various concentrations of the drugs. Rickettsial growth was evaluated by direct visual counts of rickettsiae in Giemsastained cells or by flow cytometry, Initial tests were conducted at the concentration of each antibiotic considered to be the upper breakpoint for susceptibility (16 mu g/ml for doxycycline and 8 mu g/ml for azithromycin). Growth of both Karp and AFSC-4 was strongly inhibited with both antibiotics, as measured by visual counts, although the percentage of cells infected with AFSC-3 in the presence of doxycycline was three times greater than the percentage of cells infected with Karp but was only 60% as great as the percentage of cells infected with Karp in the presence of azithromycin, Flow cytometry confirmed that rickettsial growth occurred in the absence of antibiotics, but it failed to detect it in the presence of high concentrations of either drug, Visual counts of rickettsial growth at lower concentrations of the antibiotics (0.25 to 0.0078 mu g/ml) showed that the Karp strain was 16 times more susceptible that the AFSC-4 strain to doxycycline. Azithromycin was much more effective than doxycycline against AFSC-4, inhibiting rickettsial growth at 0.0156 mu g/ml to levels below that achieved by 0.25 mu g of doxycycline per mi, Azithromycin was also more effective than doxycycline against the Karp strain, causing greater reductions in the number of rickettsiae per cell at lower concentrations. If in vivo testing confirms the in vitro effectiveness of azithromycin, it may prove to be the drug of choice for the treatment of scrub typhus in children and pregnant women, who should not take doxycycline, and in patients with refractory disease from locations where doxycycline-resistant strains of R. tsutsugamushi have been found, When tested in an in vitro assay system, azithromycin was more effective than doxycycline against doxycycline-susceptible and -resistant strains of R. tsutsugamushi. C1 USN,MED RES INST,VIRAL & RICKETTSIAL DIS PROGRAM,BETHESDA,MD 20889. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. RP STRICKMAN, D (reprint author), WALTER REED ARMY INST RES,DEPT RICKETTSIAL DIS,WASHINGTON,DC 20307, USA. NR 27 TC 42 Z9 44 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD NOV PY 1995 VL 39 IS 11 BP 2406 EP 2410 PG 5 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA TD129 UT WOS:A1995TD12900007 PM 8585717 ER PT J AU WONG, JP SARAVOLAC, EG SABUDA, D LEVY, HB KENDE, M AF WONG, JP SARAVOLAC, EG SABUDA, D LEVY, HB KENDE, M TI PROPHYLACTIC AND THERAPEUTIC EFFICACIES OF POLY(IC-CENTER-DOT-LC) AGAINST RESPIRATORY INFLUENZA-A VIRUS-INFECTION IN MICE SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Note ID POLYRIBOCYTIDYLIC ACID COMPLEX; RHESUS-MONKEYS; INTERFERON; FEVER AB Polyriboinosinic-polyribocytidylic acid [poly(IC . LC)] was evaluated for its prophylactic and therapeutic efficacies against respiratory influenza A virus infection in mice. Two doses of poly(IC . LC) (1 mg/kg of body weight per dose) administered intranasally within 12 days prior to infection with 10 50% lethal doses of mouse-adapted influenza A/PR/8 virus fully protected the mice against the infection. Determination of virus titers by hemagglutination and plaque assays showed more than a 2-log(10) decrease in virus titers in lung homogenates of pretreated mice compared with those in the lungs of the nonpretreated group. Treatment of infected mice with poly(IC . LC) resulted in a modest (40%) survival rate. These results suggest that poly(IC . LC) provides a highly effective prophylaxis against respiratory influenza A virus infection in mice. C1 NIAID,BETHESDA,MD 20892. USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702. RP WONG, JP (reprint author), DEF RES ESTAB SUFFIELD,MED COUNTERMEASURES SECT,BOX 4000,MEDICINE HAT,AB T1A 8K6,CANADA. NR 14 TC 42 Z9 44 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD NOV PY 1995 VL 39 IS 11 BP 2574 EP 2576 PG 3 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA TD129 UT WOS:A1995TD12900039 PM 8585749 ER PT J AU ADOMIAN, G MEYERS, RE AF ADOMIAN, G MEYERS, RE TI GENERALIZED NONLINEAR SCHRODINGER-EQUATION WITH TIME-DEPENDENT DISSIPATION SO APPLIED MATHEMATICS LETTERS LA English DT Article DE ADOMIAN POLYNOMIALS; TIME-DEPENDENT DISSIPATION; DECOMPOSITION METHOD; NONLINEAR SCHRODINGER EQUATION AB The generalized nonlinear Schrodinger equation with time-dependent dissipation [1] is considered using decomposition [2]. C1 USA,RES LABS,WHITE SANDS MISSILE RANGE,NM 88002. RP ADOMIAN, G (reprint author), GEN ANALYT CORP,155 CLYDE RD,ATHENS,GA 30605, USA. NR 5 TC 4 Z9 4 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0893-9659 J9 APPL MATH LETT JI Appl. Math. Lett. PD NOV PY 1995 VL 8 IS 6 BP 7 EP 8 DI 10.1016/0893-9659(95)00076-3 PG 2 WC Mathematics, Applied SC Mathematics GA TD606 UT WOS:A1995TD60600002 ER PT J AU KANTROWITZ, FT FOREMAN, DU GUTMAN, WM WINKEL, RJ AF KANTROWITZ, FT FOREMAN, DU GUTMAN, WM WINKEL, RJ TI SPECTROSCOPIC SENSING OF NH3 EMISSIONS FROM FLAME RETARDANTS SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE FOURIER TRANSFORM SPECTROSCOPY; AMMONIA; FOREST FIRE; FLAME RETARDANT AB A Fourier transform spectrometer system housed in a four-wheel drive vehicle has been developed by the Army Research Laboratory, and recently was used to observe the smoke plume from a large brush fire in the Organ Mountains of south central New Mexico. The spectrometer was approximately 8 km from the fire during data acquisition. After processing, it was apparent that emission spectra from the plume contained ammonia emission lines. Ammonia is believed to have been released by the thermal decomposition of flame retardant chemicals that were being used to contain the fire. C1 NEW MEXICO STATE UNIV,PHYS SCI LAB,LAS CRUCES,NM 88003. US MIL ACAD,DEPT PHYS,W POINT,NY 10996. RP KANTROWITZ, FT (reprint author), USA,RES LAB,WHITE SANDS MISSILE RANGE,NM, USA. NR 15 TC 3 Z9 3 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 1352-2310 J9 ATMOS ENVIRON JI Atmos. Environ. PD NOV PY 1995 VL 29 IS 22 BP 3303 EP 3307 DI 10.1016/1352-2310(95)00224-M PG 5 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA TE895 UT WOS:A1995TE89500009 ER PT J AU AYYAGARI, MS KAMTEKAR, S PANDE, R MARX, KA KUMAR, J TRIPATHY, SK AKKARA, J KAPLAN, DL AF AYYAGARI, MS KAMTEKAR, S PANDE, R MARX, KA KUMAR, J TRIPATHY, SK AKKARA, J KAPLAN, DL TI CHEMILUMINESCENCE-BASED INHIBITION-KINETICS OF ALKALINE-PHOSPHATASE IN THE DEVELOPMENT OF A PESTICIDE BIOSENSOR SO BIOTECHNOLOGY PROGRESS LA English DT Note ID FRUITS AB The use and application of the enzyme alkaline phosphatase in a chemiluminescence assay are discussed. The enzyme catalyzes the hydrolysis of a macrocyclic phosphate compound generating a chemiluminescence signal. On the basis of inhibition of this signal, a methodology for the detection and quantitation of organophosphorus-based pesticides has been developed. The methodology is studied with alkaline phosphatase in the bulk aqueous phase, and detection of the signal is accomplished by a simple optical setup. Parts per billion level detection of paraoxon and methyl parathion in bulk solutions is achieved. The technique is rapid and sensitive and is applicable to the detection of most organophosphorus-based pesticides. The results from kinetic studies indicate a mixed type of inhibition of the enzyme by paraoxon and methyl parathion. The detection methodology forms an integral part of a biosensor under development and is adaptable to incorporating optical fibers for remote detection of pesticides. C1 UNIV MASSACHUSETTS,DEPT CHEM,CTR INTELLIGENT BIOMAT,LOWELL,MA 01854. UNIV MASSACHUSETTS,DEPT CHEM,CTR ADV MAT,LOWELL,MA 01854. UNIV MASSACHUSETTS,DEPT PHYS,CTR ADV MAT,LOWELL,MA 01854. USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. NR 12 TC 18 Z9 18 U1 3 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 8756-7938 J9 BIOTECHNOL PROGR JI Biotechnol. Prog. PD NOV-DEC PY 1995 VL 11 IS 6 BP 699 EP 703 DI 10.1021/bp00036a015 PG 5 WC Biotechnology & Applied Microbiology; Food Science & Technology SC Biotechnology & Applied Microbiology; Food Science & Technology GA TJ028 UT WOS:A1995TJ02800015 PM 8541020 ER PT J AU Cardello, AV AF Cardello, AV TI Sensory evaluation and consumer food choice SO CEREAL FOODS WORLD LA English DT Editorial Material RP Cardello, AV (reprint author), USA,CTR RES DEV & ENGN,NATICK,MA, USA. NR 0 TC 7 Z9 7 U1 0 U2 1 PU AMER ASSOC CEREAL CHEMISTS PI ST PAUL PA 3340 PILOT KNOB RD, ST PAUL, MN 55121-2097 SN 0146-6283 J9 CEREAL FOOD WORLD JI Cereal Foods World PD NOV-DEC PY 1995 VL 40 IS 11 BP 876 EP & PG 2 WC Food Science & Technology SC Food Science & Technology GA TL091 UT WOS:A1995TL09100012 ER PT J AU HURWITZ, KM ARGYROS, GJ ROACH, JM ELIASSON, AH PHILLIPS, YY AF HURWITZ, KM ARGYROS, GJ ROACH, JM ELIASSON, AH PHILLIPS, YY TI INTERPRETATION OF EUCAPNIC VOLUNTARY HYPERVENTILATION IN THE DIAGNOSIS OF ASTHMA SO CHEST LA English DT Article DE ASTHMA; BRONCHOPROVOCATION; EXERCISE-INDUCED ASTHMA; HYPERVENTILATION ID EXERCISE-INDUCED BRONCHOSPASM; BRONCHIAL HYPERREACTIVITY; CHALLENGE AB Eucapnic voluntary hyperventilation (EVH) of dry gas is a physiologic bronchoprovocation challenge useful in the diagnosis of asthma. To determine the best parameter and threshold for diagnosis and the proper timing of postchallenge measurements, we reviewed 120 challenges, comparing the decrement from baseline in FVC, FEV(1), mean forced expiratory flow during the middle half of the FVC (FEF(25-75%)), and peak expiratory flow rate (PEFR) each at 0, 5, 10, and 20 min postchallenge. After adjustment to a standard minute ventilation of 30 times the baseline FEV(1) for 6 min, the mean response by 90 mild asthmatics differed from 30 normal subjects in all four parameters (p<0.0001). In asthmatics, maximum decline fr om baseline (mean+/-SEM) was as follows: FVC, 12.1+/-1.2%; FEV(1), 19.7+/-1.7%; FEF(25-75%), 33.5+/-2.5%; and PEFR, 29.0+/-1.9%. Normal subjects had a maximum fall as follows: FVC, 2.9+/-0.7%; FEV(1), 3.8+/-0.7%; FEF(25-75%), 11.8+/-2.0%; and PEFR, 11.5+/-1.0%. Based on comparison of receiver operator characteristic curves, FEV(1) was more accurate than FEF(25-75%) and equivalent to FVC and PEFR. A threshold of 10% change or greater in FEV(1) had a specificity of 90%, with a sensitivity of 63.3%. A threshold of 15% or greater had a specificity of 100%, with a sensitivity of 53.3%. The FEV(1) fell by 10% or more in 55 of 90 asthmatics at 5 or 10 min after hyperventilation. Measurements al 0 or 20 min added two additional positive responses. We conclude that in the proper clinical setting, subjects whose FEV(1) declines by 10% or more at 5 or 10 min after EVH should be diagnosed as having asthma. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP HURWITZ, KM (reprint author), WALTER REED ARMY MED CTR,DEPT MED,PULM & CRIT CARE MED SERV,WASHINGTON,DC 20307, USA. NR 17 TC 48 Z9 50 U1 0 U2 2 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD NOV PY 1995 VL 108 IS 5 BP 1240 EP 1245 DI 10.1378/chest.108.5.1240 PG 6 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA TD708 UT WOS:A1995TD70800018 PM 7587423 ER PT J AU FOLEY, DA AF FOLEY, DA TI FLOOD-CONTROL DOESNT HAVE TO BE UGLY SO CIVIL ENGINEERING LA English DT Article RP FOLEY, DA (reprint author), USA,CORPS ENGINEERS,DIV PROGRAMS & PROJECT MANAGEMENT,ST PAUL,MN, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0885-7024 J9 CIVIL ENG JI Civil Eng. PD NOV PY 1995 VL 65 IS 11 BP 51 EP 53 PG 3 WC Engineering, Civil SC Engineering GA TB671 UT WOS:A1995TB67100016 ER PT J AU HYAMS, KC MALONE, JD BOURGEOIS, AL HAWKINS, R HALE, TL MURPHY, JR AF HYAMS, KC MALONE, JD BOURGEOIS, AL HAWKINS, R HALE, TL MURPHY, JR TI SERUM ANTIBODY TO LIPOPOLYSACCHARIDE ANTIGENS OF SHIGELLA SPECIES AMONG US MILITARY PERSONNEL DEPLOYED TO SAUDI-ARABIA AND KUWAIT DURING OPERATIONS DESERT-SHIELD AND DESERT-STORM SO CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY LA English DT Article ID NATURAL IMMUNITY; O-ANTIGEN; VACCINE; INFECTIONS AB During Operations Desert Shield and Desert Storm, U.S. troops were at high risk of diarrheal disease due to Shigella spp., particularly Shigella sonnei. In order to better understand the serologic response to Shigella infection, 830 male U.S. combat troops were evaluated before and after the deployment to Saudi Arabia and Kuwait for immunoglobulin A (IgA) and IgG anti-Shigella lipopolysaccharide (LPS) (antibody to S. sonnei form I and Shigella flexneri serotypes 1a, 2a, and 3a) in serum. Just before deployment, 103% of the subjects were seropositive for IgA and 18.3% were positive for IgG anti-Shigella LPS. IgA and IgG anti-LPS antibody levels in serum prior to deployment were significantly associated with nonwhite race and ethnicity, birth outside the United States, and antibody to hepatitis A virus and Helicobacter pylori. During the deployment, which lasted for a mean of 131 days, 60% of the subjects reported at least one episode of diarrhea and 15% reported an episode of diarrhea with feverishness; also, 5.5% of the subjects exhibited IgA seroconversion to Shigella LPS and 14.0% exhibited IgG seroconversion, A significant association between the development of diarrheal symptoms and either positive predeployment anti-LPS antibody or seroconversion was not found, These data indicate that in this population of U.S. Desert Storm troops,who were at high risk of Shigella infection, there was no apparent relation between IgA or IgG anti-Shigella LPS in serum and diarrheal disease. C1 NATL NAVAL MED CTR, DIV INFECT DIS, BETHESDA, MD 20889 USA. WALTER REED ARMY MED CTR, DIV COMMUN DIS & IMMUNOL, WASHINGTON, DC 20307 USA. UNIV TEXAS, HLTH SCI CTR, CTR INFECT DIS, HOUSTON, TX USA. USN, MED RES UNIT 3, CAIRO, EGYPT. RP HYAMS, KC (reprint author), USN, MED RES INST, DEPT INFECT DIS, 12300 WASHINGTON AVE, ROCKVILLE, MD 20852 USA. NR 16 TC 6 Z9 6 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 1071-412X J9 CLIN DIAGN LAB IMMUN JI Clin. Diagn. Lab. Immunol. PD NOV PY 1995 VL 2 IS 6 BP 700 EP 703 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA TD038 UT WOS:A1995TD03800012 PM 8574833 ER PT J AU Sfikakis, PP Tsokos, GC AF Sfikakis, PP Tsokos, GC TI Lymphocyte adhesion molecules in autoimmune rheumatic diseases: Basic issues and clinical expectations SO CLINICAL AND EXPERIMENTAL RHEUMATOLOGY LA English DT Review DE adhesion molecules; autoimmune diseases; costimulation; lymphocyte homing; rheumatoid arthritis; systemic lupus erythematosus; scleroderma ID SYSTEMIC LUPUS-ERYTHEMATOSUS; UP-REGULATED EXPRESSION; T-CELL ADHESION; SCLERODERMA FIBROBLASTS; MONOCLONAL-ANTIBODIES; ADJUVANT ARTHRITIS; SYNOVIAL-FLUID; INTEGRIN; RECEPTOR; SKIN AB Lymphocyte adhesion molecules are of crucial importance in (auto)immune and inflammatory responses in two ways: on the one hand they mediate the interactions between lymphocytes and vascular endothelial cells during extravasation and homing, and allow local retention by aiding adhesion to extracellular matrix components, and on the other they increase T cell-antigen presenting cell contact and deliver the necessary signals for effective T-helper and T-cytotoxic cell function. Aberrations in adhesive interaction between numbers of the three major families of adhesion molecules, namely between selectins and their carbohydrate ligands, integrins and their ligands, and between members of the immunoglobulin superfamily, may participate in a vicious circle ending in organ damage. Findings regarding the overexpression of a number of adhesion molecules in patients with autoimmune rheumatic diseases, which is induced at the sites of inflammation and autoimmune injury, probably as a result of cell activation, exposure to cytokines or other soluble mediators, are summarized in the present review. Specific aberrations in adhesion molecule expression confined to one particular disease have not yet been described. increased levels of soluble forms of various adhesion molecules that have been found in the serum of these patients reflect cell activation and may have physiological in vivo effects by interfering with cell-cell interactions. Although circulating adhesion molecule measurements lack specificity, longitudinal studies may establish their clinical value in the monitoring or the prognosis of patients. Modulation of adhesion mechanisms is likely to play an important role in the treatment of autoimmune rheumatic diseases in the near future. indeed preliminary results in patients with long-standing, refractory RA treated with a monoclonal antibody to intercellular adhesion molecule-1 are promising. However, much more has to be learned regarding the function and significance of adhesion molecules in order to successfully apply research findings to the clinical setting. C1 UNIV ATHENS,SCH MED,DEPT PROPAEDEUT MED 1,ATHENS,GREECE. WALTER REED ARMY INST RES,DEPT CLIN PHYSIOL,WASHINGTON,DC. NR 108 TC 22 Z9 26 U1 0 U2 0 PU CLINICAL & EXPER RHEUMATOLOGY PI PISA PA VIA SANTA MARIA 31, 56126 PISA, ITALY SN 0392-856X J9 CLIN EXP RHEUMATOL JI Clin. Exp. Rheumatol. PD NOV-DEC PY 1995 VL 13 IS 6 BP 763 EP 777 PG 15 WC Rheumatology SC Rheumatology GA TL347 UT WOS:A1995TL34700016 PM 8835253 ER PT J AU Bauer, JJ Sesterhenn, IA Mostofi, KF McLeod, DG Srivastava, S Moul, JW AF Bauer, JJ Sesterhenn, IA Mostofi, KF McLeod, DG Srivastava, S Moul, JW TI P53 nuclear protein expression is an independent prognostic marker in clinically localized prostate cancer patients undergoing radical prostatectomy SO CLINICAL CANCER RESEARCH LA English DT Article ID ADENOCARCINOMA; ACCUMULATION; CARCINOMAS; MUTATIONS AB Immunohistochemical (IHC) staining for p53 protein nuclear expression was evaluated in archival paraffin-embedded radical prostatectomy specimens from 139 patients with clinically localized prostate cancer followed up from 1 to 8 (mean, 4) years, Elevated nuclear p53 protein expression was detected in 85 (61%) of 139 patients, being heterogeneous and focal in the majority of specimens, Only four specimens displayed homogeneous nuclear accumulation of p53 protein, Disease progression, most commonly prostate-specific antigen elevation, was noted in 46 (33%) patients, with 39 (85%) having positive p53 protein IHC stains, Conversely, 93 (67%) of 139 have not recurred, with 46 (49%) having positive p53, Of all 54 p53-negative patients, 47 (87%) have had no disease recurrence, An increased p53 protein IHC stain was associated with a higher pathological stage (T-1 and T-2, 51% versus greater than or equal to T-3, 69%) and Gleason score (2-4, 17%; 5-7, 72%; and 8-10, 87.5%), Despite these associations, p53 IHC staining was an independent predictor of disease-free survival in a multivariate analysis of p53, age, race, stage, and grade, This study revealed that a majority of clinically localized prostate cancers heterogeneously express elevated nuclear levels of p53 protein in at least a subset of malignant cells, and that this expression is an independent predictor of disease progression in prostate cancer patients after radical prostatectomy. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,CTR PROSTRATE DIS RES,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT SURG,UROL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,DEPT GENITOURINARY PATHOL,WASHINGTON,DC 20306. NR 44 TC 91 Z9 94 U1 0 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 1078-0432 J9 CLIN CANCER RES JI Clin. Cancer Res. PD NOV PY 1995 VL 1 IS 11 BP 1295 EP 1300 PG 6 WC Oncology SC Oncology GA TL086 UT WOS:A1995TL08600008 PM 9815924 ER PT J AU PLEMMONS, RM DOOLEY, DP LONGFIELD, RN AF PLEMMONS, RM DOOLEY, DP LONGFIELD, RN TI SEPTIC THROMBOPHLEBITIS OF THE PORTAL-VEIN (PYLEPHLEBITIS) - DIAGNOSIS AND MANAGEMENT IN THE MODERN-ERA SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID SUPPURATIVE PYLEPHLEBITIS; ANAEROBIC BACTEREMIA; THROMBOSIS; DIVERTICULITIS; PYLETHROMBOSIS; APPENDICITIS AB Pylephlebitis usually occurs secondary to infection in the region drained by the portal venous system. We describe a case of pylephlebitis at our institution and examine 18 other cases culled from the literature since 1979, reviewing diagnostic and management issues. A precipitating focus of infection (most commonly diverticulitis) was identified in 13 (68%) of the cases. Bacteremia (often polymicrobial) was present in 88% of the patients. The most common blood isolate was Bacteroides fragilis. Overall mortality was 32%, but most of the patients who died had severe sepsis prior to the initiation of antibiotic therapy. In no case was improvement in a patient's clinical status clearly attributable to the use of heparin, but some beneficial effect of anticoagulation could not be ruled out. This report is the first to examine the published experience with pylephlebitis during the era of antibiotics and modern imaging and is also the first to review critically the role of anticoagulation in the management of this disease. RP PLEMMONS, RM (reprint author), BROOKE ARMY MED CTR,MED CORPS,DEPT MED,INFECT DIS SERV,FT SAM HOUSTON,TX 78234, USA. NR 32 TC 119 Z9 122 U1 0 U2 3 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD NOV PY 1995 VL 21 IS 5 BP 1114 EP 1120 DI 10.1093/clinids/21.5.1114 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA TC172 UT WOS:A1995TC17200006 PM 8589130 ER PT J AU MULLER, HE FANNING, GR BRENNER, DJ AF MULLER, HE FANNING, GR BRENNER, DJ TI ISOLATION OF EWINGELLA-AMERICANA FROM MOLLUSKS SO CURRENT MICROBIOLOGY LA English DT Article ID ENTEROBACTERIACEAE; PSEUDOBACTEREMIA; BACTEREMIA; SPECIMENS AB Twenty-three of 2446 strains of Enterobacteriaceae isolated from mollusks were identified as Ewingella americana both biochemically and by DNA hybridization with strain S6/1111, The biochemical characteristics of the new strains showed few differences from previously reported strains obtained from human clinical specimens. These are the first strains off. americana isolated from animals. C1 WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC 20307. CTR DIS CONTROL & PREVENT,NATL CTR INFECT DIS,EMERGING BACTERIAL & MYCOT DIS BRANCH,ATLANTA,GA 30333. NR 16 TC 11 Z9 11 U1 0 U2 3 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0343-8651 J9 CURR MICROBIOL JI Curr. Microbiol. PD NOV PY 1995 VL 31 IS 5 BP 287 EP 290 DI 10.1007/BF00314581 PG 4 WC Microbiology SC Microbiology GA RX741 UT WOS:A1995RX74100004 PM 7580799 ER PT J AU LAVERY, LA LAVERY, DC QUEBEDEAXFARNHAM, TL AF LAVERY, LA LAVERY, DC QUEBEDEAXFARNHAM, TL TI INCREASED FEET PRESSURES AFTER GREAT TOE AMPUTATION IN DIABETES SO DIABETES CARE LA English DT Article ID FOOT; LIMB; ABNORMALITIES AB OBJECTIVE - To compare peak pressures on the sole of the foot in non-insulin-dependent diabetic patients with isolated, unilateral amputations of the great toe and first metatarsal with the patients' contralateral, intact foot. RESEARCH DESIGN AND METHODS - Eleven patients with a unilateral great toe and partial first metatarsal amputation of at least 6 months duration were evaluated with the F-Scan in-shoe pressure measurement system. Patients were studied in the same brand and style of footwear-a thin, rubber-soled, canvas boar shoe. We compared mean peak plantar foot pressures under the first metatarsal, lesser metatarsals, lesser toes, and heel in feel with and without a great toe amputation using the Wilcoxon's matched pairs signed-rank test. RESULTS - Peak fool pressures were significantly higher under the first metatarsal head (P = 0.046), lesser metatarsal heads (P < 0.001), and toes (P < 0.001) in feet with a great toe amputation compared with the contralateral foot without an amputation. Pressure under the heel was higher on the contralateral foot (P < 0.01). CONCLUSIONS - After a great toe amputation pressure distribution of the foot is significantly altered. Because preamputation risk factors such as peripheral neuropathy, foot deformity, and limited joint mobility for many of these patients remain unchanged, an increase in foot pressures contributes to an increased risk of reulceration and reamputation in these patients. C1 US MIL ACAD,DEPT MATH SCI,W POINT,NY 10996. RP LAVERY, LA (reprint author), UNIV TEXAS,HLTH SCI CTR,MEXICAN AMER MED TREATMENT EFFECTIVENESS RES CTR,DEPT ORTHOPAED,SAN ANTONIO,TX 78284, USA. NR 33 TC 58 Z9 58 U1 0 U2 1 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1660 DUKE ST, ALEXANDRIA, VA 22314 SN 0149-5992 J9 DIABETES CARE JI Diabetes Care PD NOV PY 1995 VL 18 IS 11 BP 1460 EP 1462 DI 10.2337/diacare.18.11.1460 PG 3 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA TA213 UT WOS:A1995TA21300007 PM 8722070 ER PT J AU GARTNER, LA POTH, M AF GARTNER, LA POTH, M TI GRAVES-DISEASE IN CHILDREN AND ADOLESCENTS SO ENDOCRINOLOGIST LA English DT Article ID AUTOIMMUNE THYROID-DISEASE; THYROTROPIN-RECEPTOR; FOLLOW-UP; ANTIBODY DETERMINATIONS; HYPERTHYROIDISM; THYROTOXICOSIS; MANAGEMENT; CHILDHOOD; THERAPY; OPHTHALMOPATHY AB We present two cases which illustrate the diversity of presentation characterizing childhood Graves' disease. We also review current concepts of diagnosis and treatment with emphasis on aspects of care which are unique to the pediatric age group. C1 UNIFORMED SERV UNIV HLTH SCI,SCH MED,DEPT PEDIAT,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 53 TC 3 Z9 3 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1051-2144 J9 ENDOCRINOLOGIST JI Endocrinologist PD NOV PY 1995 VL 5 IS 6 BP 422 EP 430 DI 10.1097/00019616-199511000-00006 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA TH840 UT WOS:A1995TH84000005 ER PT J AU Krinitzsky, EL AF Krinitzsky, EL TI Deterministic versus probabilistic seismic hazard analysis for critical structures SO ENGINEERING GEOLOGY LA English DT Article AB Probabilistic seismic hazard analysis has been practically unchallenged since its inception three decades ago. However, information has been accumulating which shows convincingly that PSHA is a defective procedure. Its greatest weakness is the dependence of the probability theory on the Gutenberg-Richter magnitude and a recurrence relation which can no longer be regarded as a power law. Remedies that rely on incorporating paleoseismic information and characteristic earthquakes into the probability calculation introduce other errors resulting from fragmentary data and the known non-uniformity of earthquake occurrence in space and time. The worst corrective for probability is the method developed by the Electric Power Research Institute and the Lawrence Livermore National Laboratory that averages multiple expert opinions. Expert opinions cannot be averaged meaningfully because the criteria for different models are nonequivalent. On the other hand, the deterministic procedure for earthquake hazard evaluation avoids the above defects by eliminating the falsely precise time element in the probabilistic estimation. Geologic time for recurrence is used, according to accepted criteria such as a single movement in the past 12,000 years or multiple movements in 500,000 years. For a critical project, where the consequences of failure are intolerable and protection is needed against the worst that can be reasonably expected to occur (the maximum credible earthquake), the deterministic method is strongly recommended. RP Krinitzsky, EL (reprint author), CORPS ENGINEERS,WATERWAYS EXPT STN,GEOTECH LAB,VICKSBURG,MS 39180, USA. NR 6 TC 28 Z9 30 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0013-7952 J9 ENG GEOL JI Eng. Geol. PD NOV PY 1995 VL 40 IS 1-2 BP 1 EP 7 DI 10.1016/0013-7952(95)00031-3 PG 7 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA TM788 UT WOS:A1995TM78800001 ER PT J AU HASHSHAM, SA SCHOLZE, R FREEDMAN, DL AF HASHSHAM, SA SCHOLZE, R FREEDMAN, DL TI COBALAMIN-ENHANCED ANAEROBIC BIOTRANSFORMATION OF CARBON-TETRACHLORIDE SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID TRANSITION-METAL COENZYMES; REDUCTIVE DEHALOGENATION; CHLORINATED HYDROCARBONS; METHANOGENIC CONDITIONS; ACETOBACTERIUM-WOODII; TRANSFORMATION; DECHLORINATION; MONOXIDE; TETRACHLOROMETHANE; CYTOCHROME-P-450 AB Biotransformation of carbon tetrachloride (CT) was examined with an anaerobic enrichment culture grown on dichloromethane as the sole organic carbon and energy source. The principal products from [C-14]-CT included chloroform (17%), carbon disulfide (21%), and CO2 (21%). When cyanocobalamin was added along with CT, the percentage converted to CO2 increased almost 3-fold (59%), while CS2 decreased somewhat (11%), and virtually none of the CT (<1%) was reduced to chloroform. Carbon monoxide was a major transformation product (12-27%) in autoclaved cultures and in live cultures that received high levels of CT (up to 52 mg/L). Adding cyanocobalamin also increased the rate of CT transformation in live cultures by at least 10-fold, but had a minor effect on the rate of CT use in autoclaved cultures. Accelerated rates of transformation by live cultures were sustained for as long as 200 days, with hydrogen serving as the electron donor. Cyanocobalamin, hydroxocobalamin, and methylcobalamin were equally effective, while a 3-week lag period was required before adenosylcobalamin started to enhance CT transformation. Because of their high cost, the feasibility of using cobalamins will depend on the amount required. We observed significant enhancement in CT transformation at concentrations up to 340 mu M, with cobalamin levels as low as 10 mu M. C1 UNIV ILLINOIS,DEPT CIVIL ENGN,ENVONM ENGN & SCI PROGRAM,URBANA,IL 61801. USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61820. NR 39 TC 34 Z9 35 U1 4 U2 12 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD NOV PY 1995 VL 29 IS 11 BP 2856 EP 2863 DI 10.1021/es00011a023 PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA TC856 UT WOS:A1995TC85600041 PM 22206535 ER PT J AU GRANT, CL JENKINS, TF MYERS, KF MCCORMICK, EF AF GRANT, CL JENKINS, TF MYERS, KF MCCORMICK, EF TI HOLDING-TIME ESTIMATES FOR SOILS CONTAINING EXPLOSIVES RESIDUES - COMPARISON OF FORTIFICATION VS FIELD CONTAMINATION SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE EXPLOSIVES; HOLDING TIMES; TNT; RDX; FORTIFICATION ID LIQUID-CHROMATOGRAPHIC METHOD; DESORPTION; 2,4,6-TRINITROTOLUENE; BIOAVAILABILITY; KINETICS; SAMPLES AB Maximum acceptable preextraction analytical holding times (MHTs) were estimated by spiking aqueous solutions of two nitramines, octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and three nitroaromatics, 1,3,5-trinitrobenzene (TNB), 2,4,6-trinitrotoluene (TNT), and 2,4-dinitrotoluene (2,4-DNT), into three soils. Nitramines were stable over an 8-week test period at all storage temperatures, but nitroaromatics, which were reasonably stable when frozen, degraded rapidly at room temperature and more slowly under refrigeration. In contrast, both nitroaromatics and nitramines were quite stable under refrigeration for four field-contaminated soils. When three of these field-contaminated soils were subsequently fortified with TNT and TNB, rapid degradation under refrigeration was again observed for the added nitroaromatics. The rates of degradation were quite different in the three soils, further emphasizing the uncertainties in MHT estimates derived from fortified soils. We conclude that fortified soils can produce very different estimates of MHTs, recoveries, treatability, etc., compared to field-contaminated soils even when spiking is done in aqueous media. C1 USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. UNIV NEW HAMPSHIRE,DEPT CHEM,DURHAM,NH 03824. USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180. NR 32 TC 16 Z9 17 U1 0 U2 1 PU SETAC PRESS PI PENSACOLA PA 1010 NORTH 12TH AVE, PENSACOLA, FL 32501-3370 SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD NOV PY 1995 VL 14 IS 11 BP 1865 EP 1874 DI 10.1897/1552-8618(1995)14[1865:HEFSCE]2.0.CO;2 PG 10 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA TB369 UT WOS:A1995TB36900008 ER PT J AU HAAS, EC CASALI, JG AF HAAS, EC CASALI, JG TI PERCEIVED URGENCY OF AND RESPONSE-TIME TO MULTITONE AND FREQUENCY-MODULATED WARNING SIGNALS IN BROAD-BAND NOISE SO ERGONOMICS LA English DT Article DE AUDITORY WARNINGS; AUDITORY DISPLAYS; PERCEIVED URGENCY; WARNING SIGNALS AB Several pulse parameters that were believed to affect the perceived urgency and response time to auditory warning signals were investigated in a factorial experiment. The independent variables included pulse format (sequential, simultaneous, and frequency-modulated pulses), pulse level (65 and 79 dBC), and inter-pulse interval (0, 150 and 300 ms). The applications environments of interest were those having steady-state broadband noise. A probability monitoring task from the Criterion Task Set was used as an operator loading task to impose additional attentional demands during the signal detection and response task. The psychophysical methods of free-modulus magnitude estimation and paired comparison were used to measure subjective perceived urgency. An objective measure of response time to the signal was also obtained. Multivariate statistical analyses indicated that response time decreased significantly as perceived urgency increased. Perceived urgency of the signal increased and response time decreased as pulse level increased. Sequential signals took longer to detect and were rated as less urgent than the other two signal types. Shorter inter-pulse interval was associated with greater perceived signal urgency. C1 VIRGINIA POLYTECH INST & STATE UNIV,BLACKSBURG,VA 24061. RP HAAS, EC (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21010, USA. NR 19 TC 50 Z9 50 U1 0 U2 4 PU TAYLOR & FRANCIS LTD LONDON PI LONDON PA ONE GUNDPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 0014-0139 J9 ERGONOMICS JI Ergonomics PD NOV PY 1995 VL 38 IS 11 BP 2313 EP 2326 DI 10.1080/00140139508925270 PG 14 WC Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Engineering; Psychology GA TE257 UT WOS:A1995TE25700013 PM 7498190 ER PT J AU Burris, HA Rothenberg, ML AF Burris, HA Rothenberg, ML TI Gemcitabine is effective as palliative therapy for 5FU-refractory pancreas cancer patients SO EUROPEAN JOURNAL OF CANCER LA English DT Meeting Abstract C1 UNIV TEXAS,HLTH SCI CTR,CANC THERAPY & RES CTR,SAN ANTONIO,TX. BROOKE ARMY MED CTR,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0959-8049 J9 EUR J CANCER JI Eur. J. Cancer PD NOV PY 1995 VL 31A SU 5 BP 550 EP 550 PG 1 WC Oncology SC Oncology GA TH919 UT WOS:A1995TH91900552 ER PT J AU STEPHENS, HAF BROWN, AE CHANDANAYINGYONG, D WEBSTER, HK SIRIKONG, M LONGTA, P VANGSERATTHANA, R GORDON, DM LEKMAK, S RUNGRUANG, E AF STEPHENS, HAF BROWN, AE CHANDANAYINGYONG, D WEBSTER, HK SIRIKONG, M LONGTA, P VANGSERATTHANA, R GORDON, DM LEKMAK, S RUNGRUANG, E TI THE PRESENCE OF THE HLA CLASS-II ALLELE DPB1-ASTERISK-0501 IN ETHNIC THAIS CORRELATES WITH AN ENHANCED VACCINE-INDUCED ANTIBODY-RESPONSE TO A MALARIA SPOROZOITE ANTIGEN SO EUROPEAN JOURNAL OF IMMUNOLOGY LA English DT Article DE HLA-DP; ANTIBODY; IMMUNE RESPONSE; MALARIA; VACCINE ID T-CELL CLONES; DEPENDENT DIABETES-MELLITUS; DP-BETA ALLELE; PLASMODIUM-FALCIPARUM; RHEUMATOID-ARTHRITIS; CIRCUMSPOROZOITE PROTEIN; GENE POLYMORPHISMS; IMMUNE-RESPONSES; CELIAC-DISEASE; SUSCEPTIBILITY AB In this study, we examined the correlation between the frequency of allelic variants of the class II human leukocyte antigen (HLA) DR, DQ and DP gene loci and the quantitative humoral immune response observed in 71 Thai volunteers, subsequent to vaccination with a conjugated subunit vaccine. This vaccine was designed to induce antibodies directed against the immunodominant repeat region of the Plasmodium falciparum circumsporozoite (CS) protein. The presence of the DPB1*0501, a relatively common allele in Asian populations, was found to be associated with high vaccine-induced CS repeat-specific antibody responses in the volunteers. Given the increasing focus on the use of subunit vaccines in the control of infectious diseases, consideration of the influence of class II allele frequencies in ethnically diverse recipient populations may be important. C1 AFRIMS,DEPT IMMUNOL,BANGKOK,THAILAND. WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC. RP STEPHENS, HAF (reprint author), MAHIDOL UNIV,SIRIRAJ HOSP & MED SCH,DEPT TRANSFUS MED,BANGKOK 10700,THAILAND. NR 45 TC 31 Z9 31 U1 0 U2 1 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0014-2980 J9 EUR J IMMUNOL JI Eur. J. Immunol. PD NOV PY 1995 VL 25 IS 11 BP 3142 EP 3147 DI 10.1002/eji.1830251123 PG 6 WC Immunology SC Immunology GA TE647 UT WOS:A1995TE64700022 PM 7489755 ER PT J AU NAMNOUM, AB GEHLBACH, DL HICKMAN, TN ROCK, JA GOODMAN, SB AF NAMNOUM, AB GEHLBACH, DL HICKMAN, TN ROCK, JA GOODMAN, SB TI INCIDENCE OF SYMPTOM RECURRENCE AFTER HYSTERECTOMY FOR ENDOMETRIOSIS SO FERTILITY AND STERILITY LA English DT Article DE ENDOMETRIOSIS; OVARIAN CONSERVATION; HYSTERECTOMY; ESTROGEN REPLACEMENT; COX HAZARD MODEL; MULTIVARIATE ANALYSIS; SYMPTOM RECURRENCE; REOPERATION ID HORMONAL PSEUDOPREGNANCY AB Objectives: To determine the relative risk of symptom recurrence and/or reoperation after hysterectomy with ovarian preservation for the treatment of endometriosis, Design: Historical prospective study of patients with endometriosis who underwent hysterectomy with or without ovarian preservation. Patients: One hundred thirty-eight women who underwent hysterectomy with the diagnosis of endometriosis. Methods: A computer search identified 138 women who underwent hysterectomy with the diagnosis of endometriosis at Johns Hopkins Hospital from 1979 to 1991, Follow-up information was obtained from medical records, outpatient charts, and telephone surveys. Results: Twenty-nine women had hysterectomy with some ovarian tissue preserved; 109 had all ovarian tissue removed. Of those with ovarian preservation, 18 of 29 (62%) had recurrent pain and 9 of 29 (31%) required reoperation. Of those who had no ovarian preservation, 11 of 109 (10%) had recurrent symptoms and 4 of 109 (3.7%) required reoperation. Ovarian conservation was associated with a relative risk for pain recurrence of 6.1 (95% confidence interval [CI] 2.5 to 14.6) compared with patients with oophorectomy in a Cox proportional hazards model, The relative risk for reoperation in patients with ovarian conservation was 8.1 (95% CI 2.1 to 31.3). Conclusion: Compared with women who had oophorectomy for endometriosis, patients who underwent hysterectomy with ovarian conservation had 6.1 times greater risk of developing recurrent pain and 8.1 times greater risk of reoperation. C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. EMORY UNIV,ATLANTA,GA 30322. RP NAMNOUM, AB (reprint author), JOHNS HOPKINS UNIV HOSP,DEPT GYNECOL & OBSTET,DIV REPROD ENDOCRINOL,600 N WOLFE ST,HOUCK BLDG,BALTIMORE,MD 21287, USA. NR 15 TC 99 Z9 105 U1 0 U2 6 PU AMER SOC REPRODUCTIVE MEDICINE PI BIRMINGHAM PA 1209 MONTGOMERY HIGHWAY, BIRMINGHAM, AL 35216-2809 SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD NOV PY 1995 VL 64 IS 5 BP 898 EP 902 PG 5 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA TA666 UT WOS:A1995TA66600003 PM 7589631 ER PT J AU SARNO, AP POLZIN, WJ FEINSTEIN, SJ MASLOW, A AF SARNO, AP POLZIN, WJ FEINSTEIN, SJ MASLOW, A TI TRANSABDOMINAL AMNIOINFUSION IN PRETERM PREGNANCIES COMPLICATED BY FETAL GROWTH RESTRICTION, OLIGOHYDRAMNIOS AND UMBILICAL-CORD COMPRESSION SO FETAL DIAGNOSIS AND THERAPY LA English DT Article DE FETAL GROWTH RESTRICTION; OLIGOHYDRAMNIOS; AMNIOINFUSION AB Fetal growth restriction with oligohydramnios occurring in the preterm gestation is associated with significant fetal morbidity and mortality. We investigated the possibility that transabdominal amnioinfusion might relieve acute cord compression and allow prolongation of gestation long enough to administer corticosteroids. Four patients with fetal growth restriction, oligohydramnios and evidence of significant cord compression with otherwise reassuring fetal heart rate testing underwent transabdominal amnioinfusion. Pregnancy was prolonged 22, 38, 10 and 9 days, and cord compression was relieved in all cases. One patient showed findings consistent with reversal of chronic hypoxemia with stabilization of amniotic fluid index measurements in the normal range and normalization of fetal growth. Transabdominal amnioinfusion may be useful as an adjunctive technique to prolong pregnancy in preterm gestations with fetal growth restriction, oligohydramnios and evidence of umbilical cord compression. C1 TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,MATERNAL FETAL MED SERV,CTR ANTEPARTUM DIAGNOST,HONOLULU,HI. NR 0 TC 13 Z9 13 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1015-3837 J9 FETAL DIAGN THER JI Fetal Diagn. Ther. PD NOV-DEC PY 1995 VL 10 IS 6 BP 408 EP 414 PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA TD399 UT WOS:A1995TD39900009 PM 8579780 ER PT J AU Davis, RE McKenzie, JC Jordan, R AF Davis, RE McKenzie, JC Jordan, R TI Distributed snow process modelling: An image processing approach SO HYDROLOGICAL PROCESSES LA English DT Article; Proceedings Paper CT 52nd Eastern Snow Conference (ESC) CY JUN, 1995 CL TORONTO, CANADA SP ESC, Hydrol Proc DE snow process modelling; image analysis; snow cover ID ALPINE CATCHMENT; COVER PATTERNS AB An approach to spatially distribute a snow process model by segmenting images of land cover, terrain and snow properties is reported. A small 1.7 ha study area with an existing database was selected for this preliminary evaluation. The methodology was carried out over a relatively flat valley bottom at Camp Grayling, Michigan. Meteorological measurements on two sides of the area showed only small differences, so uniform meteorological variables were assumed over the site. Initial snow cover conditions were reconstructed and were distributed over the area using snow maps and sparse snow pit measurements. One metre resolution terrain, soil, vegetation and snow type maps were individually processed into class maps. These layers were then combined to produce a segmented class map, where the attributes from the data layers were known for each class. A one-dimensional model of snow processes was run for each class, then the results were mapped back into images. Shallow snow conditions provided high sensitivity of ablation patterns to meteorological conditions over a 72 h period. The model performance was assessed by comparing predicted and observed ablation patterns. The error in total snow-covered area was less than 9%. However, the location errors were greater (predicted snow where no snow was observed and observed snow where no snow was predicted). Extensive error analysis was not justified because of the lack of multiple point measurements of snow properties. RP Davis, RE (reprint author), COLD REGIONS RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 15 TC 18 Z9 19 U1 0 U2 4 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0885-6087 J9 HYDROL PROCESS JI Hydrol. Process. PD NOV-DEC PY 1995 VL 9 IS 8 BP 865 EP 875 DI 10.1002/hyp.3360090804 PG 11 WC Water Resources SC Water Resources GA TN549 UT WOS:A1995TN54900003 ER PT J AU Hardy, JP Albert, MR AF Hardy, JP Albert, MR TI Snow-induced thermal variations around a single conifer tree SO HYDROLOGICAL PROCESSES LA English DT Article; Proceedings Paper CT 52nd Eastern Snow Conference (ESC) CY JUN, 1995 CL TORONTO, CANADA SP ESC, Hydrol Proc DE thermal variation; conifers; ground thermal regime; snow cover AB The influence of trees on the ground thermal regime is important to the overall winter energy exchange in a snow-covered, forested watershed. In this work, spatial zones around a single conifer tree were defined and examined for their controls on the snow cover, snow-ground interface temperatures and frozen ground extent. A large white spruce (Picea glauca), approximately 18 m tall with a crown diameter of 7.5 m and located in northern Vermont, was the subject of this study. The tree was instrumented with thermistors to measure the snow-ground interface temperature between the tree trunk and 6 m from the tree into undisturbed snow. Four distinct zones around the conifer are defined that affect the snow distribution characteristics: adjacent to the trunk; the tree well; the tree crown perimeter; and the unaffected area away from the tree. At the time of peak snow accumulation and during the ablation season, snow depth and density profiles were measured. The area beneath the canopy accumulated 34% of the snow accumulated in the undisturbed zone. By the end of the ablation season, the depth of snow under the canopy had decreased to 18% of the undisturbed snow depth. The tree and branch characteristics of spruce in this temperate climate resulted in a different snow depth profile compared with previous empirical relationships around a single conifer. A new relationship is presented for snow distribution around conifer trees that has the ability to better fit data from a variety of conifer types than previously published relationships. Less snow beneath the canopy led to colder snow-ground interface temperatures than measured in undisturbed snow. The depth of frozen ground in the different zones was modelled using a simple analytical solution that showed deeper frost penetration in the tree well than beneath the undisturbed snow. RP Hardy, JP (reprint author), USA,COLD REGIONS RES & ENGN LAB,27 LYME RD,HANOVER,NH 03755, USA. OI Albert, Mary/0000-0001-7842-2359 NR 19 TC 15 Z9 15 U1 2 U2 5 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0885-6087 J9 HYDROL PROCESS JI Hydrol. Process. PD NOV-DEC PY 1995 VL 9 IS 8 BP 923 EP 933 DI 10.1002/hyp.3360090808 PG 11 WC Water Resources SC Water Resources GA TN549 UT WOS:A1995TN54900007 ER PT J AU Lever, JH Haehnel, R AF Lever, JH Haehnel, R TI Scaling snowdrift development rate SO HYDROLOGICAL PROCESSES LA English DT Article; Proceedings Paper CT 52nd Eastern Snow Conference (ESC) CY JUN, 1995 CL TORONTO, CANADA SP ESC, Hydrol Proc DE snowdrift modeling; scaling laws; time scaling ID SNOW; REQUIREMENTS; TRANSPORT; MODEL AB For successful snowdrift modelling, measured drift shapes should be geometrically similar to full-scale shapes and develop at rates that scale in a known manner. Consensus exists on most modelling methods and the similitude requirements needed to meet these objectives. A notable exception is the manner to scale drift development rates. A rationale is presented for rate scaling based on an independent model and prototype mass transport measurements. This approach is validated by comparing the rate of drift development for a model Wyoming snow fence with corresponding field data. This method yields excellent agreement, whereas the alternatives differ substantially. RP Lever, JH (reprint author), COLD REGIONS RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 40 TC 3 Z9 4 U1 0 U2 1 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0885-6087 J9 HYDROL PROCESS JI Hydrol. Process. PD NOV-DEC PY 1995 VL 9 IS 8 BP 935 EP 946 DI 10.1002/hyp.3360090809 PG 12 WC Water Resources SC Water Resources GA TN549 UT WOS:A1995TN54900008 ER PT J AU Melloh, RA Crill, PM AF Melloh, RA Crill, PM TI Winter methane dynamics beneath ice and in snow in a temperate poor fen SO HYDROLOGICAL PROCESSES LA English DT Article; Proceedings Paper CT 52nd Eastern Snow Conference (ESC) CY JUN, 1995 CL TORONTO, CANADA SP ESC, Hydrol Proc DE methane dynamics; temperate fens; snowfall ID CH4; PEATLANDS; PEAT; BOG; CO2 AB The influence of winter on methane (CH4) stored in pore water and emitted through snow was investigated in a temperate poor fen in New Hampshire over two winters. Methane accumulated beneath ice layers (1 cm) deposited by freezing rain, resulting in snow-pore air mixing ratios as high as 140 ppmv during the first winter and 600 ppmv during the second. An early winter snow crust of 300 kg m(-3) caused no discontinuity in a linear mixing ratio profile and therefore was not observed to retard snowpack emissions. Methane concentration-depth profiles in pore water steepened and concentrations increased by as much as 400 mu M at the 10 and 20 cm depths as the ice cover formed. This suggests that the peat-ice cover plays an important part in CH4 build-up in pore water by limiting the transport of gases between the peat and the atmosphere. Pore water concentrations gradually declined through late winter. The seasonality of dissolved CH4 in pore water over two winters and one summer showed an average annual amplitude of 1.3 g CH4 m(-2) (25-75 cm depth range), with a winter maximum of 4.7 g CH4 m(-2). Emissions during the winter with average snowfall accounted for a larger percentage (9.2% in 1993-1994) of total annual emission than the winter with below-average snowfall and warmer air temperature (2% in 1994-1995). Emissions averaged 56 and 26 mg m(-2) day(-1) during the first and second winter (December, January and February), respectively. RP Melloh, RA (reprint author), USA,COLD REGIONS RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. OI Crill, Patrick/0000-0003-1110-3059 NR 22 TC 23 Z9 25 U1 1 U2 3 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0885-6087 J9 HYDROL PROCESS JI Hydrol. Process. PD NOV-DEC PY 1995 VL 9 IS 8 BP 947 EP 956 DI 10.1002/hyp.3360090810 PG 10 WC Water Resources SC Water Resources GA TN549 UT WOS:A1995TN54900009 ER PT J AU CHINNI, VR HUANG, TC WAI, PKA MENYUK, CR SIMONIS, GJ AF CHINNI, VR HUANG, TC WAI, PKA MENYUK, CR SIMONIS, GJ TI PERFORMANCE OF FIELD-INDUCED DIRECTIONAL COUPLER SWITCHES SO IEEE JOURNAL OF QUANTUM ELECTRONICS LA English DT Article ID BEAM PROPAGATION METHOD; INDUCED WAVE-GUIDES; MODE AB Switching in a GaAs field-induced, three-waveguide straight directional coupler is studied theoretically, This device can be tuned externally by changing the voltage across the waveguides, Because of this tunability, the device has some very attractive features as a switching element, The performance change due to variations in the device parameters such as length, waveguide separation, waveguide width, and wavelength of operation is numerically computed, The effect of material absorption, input and output coupling, and asymmetric excitation are included in the performance evaluation, For a device length of 1400 mu m, a crosstalk of -34 dB and a power transfer efficiency of -2 dB is predicted, while for the same device size a two-guide directional coupler is predicted a crosstalk of -13.4 dB, The device has a 400 nm voltage tunable bandwidth with a maximum crosstalk penalty of 3 dB. C1 USA,RES LAB,ADELPHI,MD 20783. UNIV MARYLAND,INST PLASMA RES,COLLEGE PK,MD 20742. RP CHINNI, VR (reprint author), UNIV MARYLAND,DEPT ELECT ENGN,CATONSVILLE,MD 21228, USA. OI Wai, Alex/0000-0002-4975-4175 NR 19 TC 1 Z9 1 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9197 J9 IEEE J QUANTUM ELECT JI IEEE J. Quantum Electron. PD NOV PY 1995 VL 31 IS 11 BP 2068 EP 2074 DI 10.1109/3.469289 PG 7 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA TC635 UT WOS:A1995TC63500025 ER PT J AU Knop, CM Libelo, LF AF Knop, CM Libelo, LF TI On the leakage radiation from a circumferentially-slotted cylinder and its application to the EMI produced by TEM-coaxial rotary joints SO IEEE TRANSACTIONS ON ELECTROMAGNETIC COMPATIBILITY LA English DT Note AB The amount of leakage radiation, as well as the radiation pattern and its gain, produced by a complete-360 degrees circumferential-narrow gap cut in a coaxial cable carrying a TEM mode is determined. Leakage levels for such a typical cable of approximately 26% are predicted to occur for gaps as small as about 0.0074 lambda. The former is substantiated by measurement on a 7/8 '' diameter coaxial cable of 50-Omega characteristic impedance operating at 2 GHz. Estimates of the EMI levels produced by typical coaxial choked-rotary joints (where the chokes significantly decrease the gap leakage) operating at high power levels are then given. C1 USA, RES LAB, ADELPHI, MD 20817 USA. RP Knop, CM (reprint author), ANDREW CORP EMRC, ORLAND PK, IL 60462 USA. NR 17 TC 6 Z9 7 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9375 J9 IEEE T ELECTROMAGN C JI IEEE Trans. Electromagn. Compat. PD NOV PY 1995 VL 37 IS 4 BP 583 EP 589 DI 10.1109/15.477344 PG 7 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA TK535 UT WOS:A1995TK53500013 ER PT J AU Cain, BL Stephenson, LD Croisant, WJ Nielsen, PH AF Cain, BL Stephenson, LD Croisant, WJ Nielsen, PH TI Design of a cyclic contact resistance test device SO IEEE TRANSACTIONS ON ELECTROMAGNETIC COMPATIBILITY LA English DT Note AB The design and operation of a cyclic contact resistance test device for electromagnetic gasket materials is described. The device and associated instrumentation provide unique capabilities to measure electrical contact resistance for up to ten gasketed test assemblies as a function of make-and-break cyclic loading of the contacts. Resistance results for a custom gasketed contact design demonstrates that the test method is sensitive to both materials and lubrication used in the contact joint. C1 USA,CONSTRUCT ENGN RES LAB,EM,FMT,CHAMPAIGN,IL 61826. RP Cain, BL (reprint author), MISSISSIPPI STATE UNIV,DEPT MECH ENGN,POB DRAWER ME,MISSISSIPPI STATE,MS 39762, USA. NR 23 TC 2 Z9 2 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9375 J9 IEEE T ELECTROMAGN C JI IEEE Trans. Electromagn. Compat. PD NOV PY 1995 VL 37 IS 4 BP 596 EP 599 DI 10.1109/15.477347 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA TK535 UT WOS:A1995TK53500016 ER PT J AU BRUNO, FF AKKARA, JA KAPLAN, DL SEKHER, P MARX, KA TRIPATHY, SK AF BRUNO, FF AKKARA, JA KAPLAN, DL SEKHER, P MARX, KA TRIPATHY, SK TI ENZYME-MEDIATED 2-DIMENSIONAL POLYMERIZATION OF AROMATIC DERIVATIVES ON A LANGMUIR TROUGH SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID PEROXIDASE AB An examination of the assembly and biocatalytic polymerization of mixed aromatic monomeric systems was undertaken using the Langmuir-Blodgett technique. Pressure-area isotherms of 4-(tetradecyloxy)phenol, 4-(hexadecyloxy)phenol, 4-(hexadecyl)aniline, 4-ethylphenol, pyrrole, aniline, and phenol in various ratios were determined. Polymerizations on the Langmuir trough were carried out using the enzymes horseradish peroxidase and laccase. UV-vis spectroscopy revealed that the polymerized monolayers possess extensive electronic conjugation in the polymer backbone. Fourier-transformed IR, attenuated total reflection-Fourier-transformed IR, thermal gravimetric analysis, conductivity, and nonlinear optical properties were measured to characterize the monolayers, to determine the extent of conjugation, to assess the orientation of the alkyl chains with respect to the substrate surface for LB films with multilayers, and to assess electrical and optical properties. C1 UNIV MASSACHUSETTS,DEPT CHEM,CTR INTELLIGENT BIOMAT,LOWELL,MA 01854. USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. UNIV TOLEDO,DEPT CHEM & MED CHEM,TOLEDO,OH 43606. RP BRUNO, FF (reprint author), UNIV MASSACHUSETTS,DEPT CHEM,CTR ADV MAT,LOWELL,MA 01854, USA. NR 13 TC 32 Z9 32 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0888-5885 J9 IND ENG CHEM RES JI Ind. Eng. Chem. Res. PD NOV PY 1995 VL 34 IS 11 BP 4009 EP 4015 DI 10.1021/ie00038a042 PG 7 WC Engineering, Chemical SC Engineering GA TD699 UT WOS:A1995TD69900042 ER PT J AU DRAZEK, ES DUBOIS, A HOLMES, RK KERSULYTE, D AKOPYANTS, NS BERG, DE WARREN, RL AF DRAZEK, ES DUBOIS, A HOLMES, RK KERSULYTE, D AKOPYANTS, NS BERG, DE WARREN, RL TI CLONING AND CHARACTERIZATION OF HEMOLYTIC GENES FROM HELICOBACTER-PYLORI SO INFECTION AND IMMUNITY LA English DT Article ID COLI ALPHA-HEMOLYSIN; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA; CAMPYLOBACTER-PYLORI; GNOTOBIOTIC PIGLETS; GASTRIC EPITHELIUM; PHOSPHOLIPASE-C; VIRULENCE; PLEUROPNEUMONIAE; PATHOGENICITY AB Strains of Helicobacter pylori, the bacterium associated with gastritis, peptic ulcer disease, and gastric cancer in humans, express different degrees of hemolysis on agar containing erythrocytes (RBC). Here we report the isolation and characterization of six recombinant clones from a genomic library of H. pylori ATCC 49503 that confer on Escherichia coli the ability to lyse sheep RBC. DNA hybridizations indicated no sequence homology among these hemolytic clones. Hybridization mapping of them to an ordered H. pylori cosmid library identified their separate chromosomal locations. One clone hybridized to two regions separated by approximately 200 kb. The specificities of the hemolytic activities of these clones were tested with RBC from humans, monkeys, cattle, horses, guinea pigs, rabbits, and chickens as well as with RBC from sheep. One clone conferred the ability to lyse RBC from five species, a second clone allowed the lysis of RBC from four of these species, three other clones allowed the lysis of RBC from three of these species, and the sixth clone allowed the lysis of RBC from just two species. We propose that some or all of the genes that confer these various hemolytic activities contribute to pathogen-host tissue interactions and that the different specificities seen here are important for H. pylori infections of humans of different genotypes or disease states. C1 ARMED FORCES INST PATHOL,DEPT INFECT & PARASIT DIS PATHOL,WASHINGTON,DC 20306. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,DIV DIGEST DIS,GASTROINTESTINAL & LIVER STUDIES LAB,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT MICROBIOL & IMMUNOL,BETHESDA,MD 20814. WASHINGTON UNIV,SCH MED,DEPT MOLEC MICROBIOL,ST LOUIS,MO 63110. RP DRAZEK, ES (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307, USA. FU NIDDK NIH HHS [DK48029] NR 43 TC 13 Z9 13 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD NOV PY 1995 VL 63 IS 11 BP 4345 EP 4349 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA TB400 UT WOS:A1995TB40000021 PM 7591069 ER PT J AU Seidel, RJ Park, OC AF Seidel, RJ Park, OC TI Applications of computer technology in instruction and training: A research framework and examples SO INSTRUCTIONAL SCIENCE LA English DT Editorial Material RP Seidel, RJ (reprint author), USA,RES INST,ALEXANDRIA,VA, USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0020-4277 J9 INSTR SCI JI Instr. Sci. PD NOV PY 1995 VL 23 IS 5-6 BP 297 EP 302 DI 10.1007/BF00896875 PG 6 WC Education & Educational Research; Psychology, Educational SC Education & Educational Research; Psychology GA TU247 UT WOS:A1995TU24700001 ER PT J AU Park, OC Gittelman, SS AF Park, OC Gittelman, SS TI Dynamic characteristics of mental models and dynamic visual displays SO INSTRUCTIONAL SCIENCE LA English DT Article AB Mental models are hypothetical constructs for explaining human cognitive processes of understanding external reality, translating the reality into internal representation and utilizing it in problem solving. Three experiments were conducted to investigate important characteristics of mental models, their influence on task performance, and instructional strategies facilitating their formation. The experiments were conducted in computer-based training environments designed to teach troubleshooting electronic logic circuits. The results suggested: (a) dynamic characteristics of mental models are important for solving problems if understanding functional behaviors of the system is required to perform the task; (b) dynamic characteristics of mental models are determined primarily by subjects' understanding of the system features and functions more than by the visually presented training contents of the system; and (c) motion simulating system functions in visual displays is more effective than static visual displays in facilitating the formation of dynamic characteristics of mental models. Consequently, dynamic visual displays are more effective than static visual displays for teaching electronic troubleshooting skills. These findings provide direct implications for the development of training programs. C1 GEORGE MASON UNIV,DEPT PSYCHOL,FAIRFAX,VA 22030. RP Park, OC (reprint author), USA,RES INST,5001 EISENHOWER AVE,ALEXANDRIA,VA 22333, USA. NR 30 TC 12 Z9 12 U1 0 U2 2 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0020-4277 J9 INSTR SCI JI Instr. Sci. PD NOV PY 1995 VL 23 IS 5-6 BP 303 EP 320 DI 10.1007/BF00896876 PG 18 WC Education & Educational Research; Psychology, Educational SC Education & Educational Research; Psychology GA TU247 UT WOS:A1995TU24700002 ER PT J AU Perez, RS Johnson, JF Emery, CD AF Perez, RS Johnson, JF Emery, CD TI Instructional design expertise: A cognitive model of design SO INSTRUCTIONAL SCIENCE LA English DT Article ID ACQUISITION; PSYCHOLOGY; SKILL AB This paper presents the results of a qualitative study of problem solving in the domain of instructional design. The study was conducted in two phases: Phase 1 consisted of a ''think-aloud'' design task with nine instructional designers, five experts and four novices. The results of Phase 2 are reported in this paper. The design task consisted of presenting the subjects with a description of a fictitious piece of equipment (a simulation of a diesel Cummins engine) and audio and video taping the participants while they produced a lesson for training subjects to trouble shoot a diesel engine simulator. Protocols were then coded using a coding scheme adapted from the work of Greeno et al. (1990). This coding scheme considers three aspects of the problem solving process involved in the development of training: subproblems, types of knowledge used, and problem solving operators. Quantitative and qualitative analysis of the ''think aloud'' protocols yielded a picture of common problem solving strategies and general features used by ''experts'' and ''novices'' during the design process. More importantly, the data showed that experts and novices use divergent design models. These design models differ with respect to the problem solving strategies used by the experts and novices. Experts are more apt to use more design principles and rely on a variety of knowledge sources than novices. Experts spend more time in front-end-analysis or planning and trying to understand the domain than novices, while novices immediately begin to consider in detail numerous design strategies. Expert design models can be characterized by breadth first with considerable elaboration between interconnections while novices' design models are depth first processing with few interconnecting linkages. Moreover, the expert design model is one of integrating, reiterating and cycling through the design process. The expert design process is not a deterministic linear activity, but rather an iterative activity that requires creativity as well as logic. C1 GEORGE MASON UNIV,DEPT PSYCHOL,FAIRFAX,VA 22030. UNIV LOUISVILLE,DEPT PSYCHOL,LOUISVILLE,KY 40292. RP Perez, RS (reprint author), USA,RES INST,5001 EISENHOWER AVE,ALEXANDRIA,VA 22333, USA. NR 42 TC 14 Z9 14 U1 2 U2 12 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0020-4277 J9 INSTR SCI JI Instr. Sci. PD NOV PY 1995 VL 23 IS 5-6 BP 321 EP 349 DI 10.1007/BF00896877 PG 29 WC Education & Educational Research; Psychology, Educational SC Education & Educational Research; Psychology GA TU247 UT WOS:A1995TU24700003 ER PT J AU Holland, VM Kaplan, JD AF Holland, VM Kaplan, JD TI Natural language processing techniques in computer-assisted language learning: Status and instructional issues SO INSTRUCTIONAL SCIENCE LA English DT Review ID FEEDBACK AB The role of natural language processing (NLP) techniques, such as parsing and semantic analysis, is described within current language tutoring systems. Significant trends are distinguished in the exploitation of these techniques, design issues and tradeoffs are examined, and current and potential contributions of NLP technology are discussed with respect to instructional theory and educational practice. Limitations and problems are addressed in using NLP tools for teaching, and approaches to assessment are considered. RP Holland, VM (reprint author), USA,RES INST,5001 EISENHOWER AVE,ALEXANDRIA,VA 22333, USA. NR 111 TC 2 Z9 2 U1 1 U2 2 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0020-4277 J9 INSTR SCI JI Instr. Sci. PD NOV PY 1995 VL 23 IS 5-6 BP 351 EP 380 DI 10.1007/BF00896878 PG 30 WC Education & Educational Research; Psychology, Educational SC Education & Educational Research; Psychology GA TU247 UT WOS:A1995TU24700004 ER PT J AU Wisher, RA Sabol, MA Kern, RP AF Wisher, RA Sabol, MA Kern, RP TI Modeling acquisition of an advanced skill: The case of Morse code copying SO INSTRUCTIONAL SCIENCE LA English DT Article ID ATTENTION AB To determine characteristics of those who pass, 21 soldiers were tracked through a course in Morse code copying. Passers differed from ''attrites'' in the form of functions relating reaction times to presentation speed (p < 0.05). We suggest this is due to differing rates of ''copying behind'' and offer a model in which an initially speeded task converts, at expert level, to one of delayed responding. We then show how the model explains otherwise puzzling data. This success demonstrates the need to understand the information-processing complexities of an advanced skill before an appropriate student model can be created for instructional purposes. RP Wisher, RA (reprint author), USA,RES INST BEHAV & SOCIAL SCI,5001 EISENHOWER AVE,ALEXANDRIA,VA 22333, USA. NR 43 TC 3 Z9 3 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0020-4277 J9 INSTR SCI JI Instr. Sci. PD NOV PY 1995 VL 23 IS 5-6 BP 381 EP 403 DI 10.1007/BF00896879 PG 23 WC Education & Educational Research; Psychology, Educational SC Education & Educational Research; Psychology GA TU247 UT WOS:A1995TU24700005 ER PT J AU Psotka, J AF Psotka, J TI Immersive training systems: Virtual reality and education and training SO INSTRUCTIONAL SCIENCE LA English DT Article AB This paper provides an introduction to the technology of virtual reality (VR) and its possibilies for education and training. It focuses on immersion as the key added value of VR, and analyzes what cognitive variables are connected to immersion, how it is generated in synthetic environments, what immersion is, and what its benefits are. The central research question is the value of tracked, immersive visual displays over non-immersive simulations. The paper provides a brief overview of existing VR research on training and transfer, education, and procedural, cognitive and maintenance training. RP Psotka, J (reprint author), USA,RES INST,PERI,IIC,5001 EISENHOWER AVE,ALEXANDRIA,VA 22333, USA. NR 76 TC 59 Z9 59 U1 1 U2 6 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0020-4277 J9 INSTR SCI JI Instr. Sci. PD NOV PY 1995 VL 23 IS 5-6 BP 405 EP 431 DI 10.1007/BF00896880 PG 27 WC Education & Educational Research; Psychology, Educational SC Education & Educational Research; Psychology GA TU247 UT WOS:A1995TU24700006 ER PT J AU Legree, PJ AF Legree, PJ TI Evidence for an oblique social intelligence factor established with a Likert-based testing procedure SO INTELLIGENCE LA English DT Article AB Many aptitude scales measure general or academic knowledge with a format in which answers are scored as either correct or incorrect. In contrast to traditional scoring procedures, quantifying performance on scales that measure interpersonal knowledge, as well as knowledge of other ambiguous relationships, requires the opinions of multiple experts, and individual responses cannot be easily or unambiguously evaluated. Given this type of uncertain knowledge domain, an obscure and little-appreciated procedure to measure expertise is based on the distance between expert and participant estimates of the relative strengths of a set of probabilistic relationships. Using this format, three scales were developed to measure knowledge associated with leadership, subtle indicators of alcohol abuse, and appropriate dinner behaviors. Data were collected with these scales using U.S. Air Force recruits for whom Armed Services Vocational Aptitude Battery scores were available. Results demonstrate (a) the applicability of the probabilistic response format to efficiently measure individual differences in nontraditional knowledge domains, such as interpersonal skills, and (b) the existence of a separate first-order factor that may be interpreted as social insight and has a substantial second-order loading on psychometric g. RP Legree, PJ (reprint author), USA,RES INST,ALEXANDRIA,VA 22191, USA. NR 23 TC 47 Z9 47 U1 3 U2 6 PU ABLEX PUBL CORP PI NORWOOD PA 355 CHESTNUT ST, NORWOOD, NJ 07648 SN 0160-2896 J9 INTELLIGENCE JI Intelligence PD NOV-DEC PY 1995 VL 21 IS 3 BP 247 EP 266 DI 10.1016/0160-2896(95)90016-0 PG 20 WC Psychology, Multidisciplinary SC Psychology GA UJ216 UT WOS:A1995UJ21600001 ER PT J AU MONTEMARANO, AD ROWE, JE BENSON, PM KRISHNAN, J AF MONTEMARANO, AD ROWE, JE BENSON, PM KRISHNAN, J TI KI-1 (CD30)-POSITIVE ANAPLASTIC LARGE-CELL LYMPHOMA MIMICKING AN INFECTIOUS GRANULOMA SO INTERNATIONAL JOURNAL OF DERMATOLOGY LA English DT Note ID HODGKINS-DISEASE; SKIN; CLASSIFICATION; EXPRESSION C1 WOMACK ARMY MED CTR,DEPT DERMATOL,FAYETVILLE,NC. ARMED FORCES INST PATHOL,DEPT HEMATOPATHOL,WASHINGTON,DC 20306. RP MONTEMARANO, AD (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 16 TC 12 Z9 12 U1 0 U2 0 PU DECKER PERIODICALS INC PI HAMILTON PA 4 HUGHSON ST, PO BOX 620, LCD 1, HAMILTON ON L8N 3K7, CANADA SN 0011-9059 J9 INT J DERMATOL JI Int. J. Dermatol. PD NOV PY 1995 VL 34 IS 11 BP 790 EP 793 DI 10.1111/j.1365-4362.1995.tb04399.x PG 4 WC Dermatology SC Dermatology GA TC629 UT WOS:A1995TC62900009 PM 8543413 ER PT J AU TESSLER, A TSUI, T SAETHER, E AF TESSLER, A TSUI, T SAETHER, E TI A (1,2)-ORDER THEORY FOR ELASTODYNAMIC ANALYSIS OF THICK ORTHOTROPIC SHELLS SO INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES LA English DT Article ID SHEAR-DEFORMATION-THEORY; HIGHER-ORDER THEORY; ANISOTROPIC SHELLS; CYLINDRICAL-SHELLS; PLATE-THEORY AB A higher-order shell theory is developed for elastodynamic analysis of orthotropic shells. The theory accounts for all basic deformations including transverse shear and transverse normal strains and stresses. The theory is developed in orthogonal curvilinear coordinates in which the reference surface components of the displacement vector vary linearly through the thickness while the transverse displacement is parabolic. Transverse shear and transverse normal strains are formulated to satisfy physical traction conditions at the top and bottom shell surfaces, and are also made least-squares compatible with the corresponding strains that are derived directly from the strain-displacement relations of three-dimensional elasticity. In these variational statements of strain compatibility, transverse shear and transverse normal correction factors are introduced, and are determined from dynamic considerations in the manner originally proposed by Mindlin. Equations of motion and associated engineering (Poisson) boundary conditions are derived from a three-dimensional variational principle. An important feature of the present theory is the requirement of only simple C-0 and C-1 continuity for the shell kinematic variables. This aspect makes the theory particularly attractive for the development of efficient shell finite elements suitable for general purpose finite element analysis of thick shell structures. Analytical solutions for the free vibration of isotropic and orthotropic cylindrical shells are obtained for a wide range of thickness/radius and thickness/wavelength ratios and found to be in close agreement with the exact elasticity solutions. C1 USA, RES LAB, MAT DIRECTORATE, WATERTOWN, MA 02172 USA. RP TESSLER, A (reprint author), NASA, LANGLEY RES CTR, COMPUTAT STRUCT BRANCH, MAIL STOP 240, HAMPTON, VA 23681 USA. RI Tessler, Alexander/A-4729-2009 NR 38 TC 5 Z9 5 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0020-7683 EI 1879-2146 J9 INT J SOLIDS STRUCT JI Int. J. Solids Struct. PD NOV PY 1995 VL 32 IS 22 BP 3237 EP 3260 DI 10.1016/0020-7683(94)00312-K PG 24 WC Mechanics SC Mechanics GA RQ933 UT WOS:A1995RQ93300001 ER PT J AU Brar, GS Palazzo, AJ AF Brar, GS Palazzo, AJ TI Tall and hard fescue responses to periodic soil water deficits SO JOURNAL OF AGRONOMY AND CROP SCIENCE-ZEITSCHRIFT FUR ACKER UND PFLANZENBAU LA English DT Article DE soil water deficits; water use; root; transpiration; fescue ID TURFGRASS AB Tall (Festuca arundinacea Schreb.) and hard (Festuca ovina var. longifolia (L.) Koch) fescues are widely sown to stabilize disturbed soils in the cool-humid and transition climatic zones of the USA. Our objectives were to: a) quantify changes in the allocation of dry matter and growth of tall and hard fescue, forced to grow on stored soil water in sandy soil; and b) compare dry matter allocation over time between roots and shoots to evaluate the dynamics of root-associated drought avoidance mechanisms. A randomized complete block experiment with four replications and two factors (species and stress level) was conducted in a greenhouse. The main blocks consisted of two fescue species: tall fescue and hard fescue; sub-blocks contained stress levels: well-watered and stressed. Low, medium and severe stresses were imposed by withholding water in one set of pots. The types of fescue species grown significantly affected leaf area (LA), plant height (PH), water use (WU), root length (RL), longest root (LR), root area (RA), shoot (SDB) and root dry biomass (RDB), and root:shoot ratio (R/S). Stress level affected PH, WU, LR and RL at low stress; WU, LR and RA at medium stress; LA, PH, SDB, WU, RL, LR, RA and R/S at severe stress. Tail fescue had greater LA, PH, WU, RA, RL, LR, SDB, RDB and R/S than hard fescue under all treatments. Stress reduced LA, PH, SDB, WU, RA, RL, LR and R/S. Significant correlations were obtained for LA with RL, WU, LR, PH, RA, SDB, RDB; RL with WU, LR, PH, RA, SDB, RDB; WU with LR, PH, RA, SDB, RDB; LR with PH, RA, SDB, RDB; PH with RA, SDB, RDB; RA with SDB, RDB; and SDB with RDB. In conclusion, hard fescue had a shallower root system, shorter plant canopy, slower growth, and transpired less water to make it more drought tolerant. Tail fescue, with a deeper root system, longer plant canopy, faster growth, and greater water transpiration, is less drought tolerant at medium and severe stresses. Root attributes strongly correlated with shoot attributes and can be considered for breeding programs promoting drought tolerance. RP Brar, GS (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 29 TC 7 Z9 7 U1 5 U2 10 PU BLACKWELL WISSENSCHAFTS-VERLAG GMBH PI BERLIN PA KURFURSTENDAMM 57, D-10707 BERLIN, GERMANY SN 0931-2250 J9 J AGRON CROP SCI JI J. Agron. Crop Sci.-Z. Acker Pflanzenbau PD NOV PY 1995 VL 175 IS 4 BP 221 EP 229 DI 10.1111/j.1439-037X.1995.tb00216.x PG 9 WC Agronomy SC Agriculture GA TR651 UT WOS:A1995TR65100002 ER PT J AU SHADRIN, VD MITIN, VV CHOI, KK KOCHELAP, VA AF SHADRIN, VD MITIN, VV CHOI, KK KOCHELAP, VA TI PHOTOCONDUCTIVE GAIN AND GENERATION-RECOMBINATION NOISE IN QUANTUM-WELL PHOTODETECTORS BIASED TO STRONG ELECTRIC-FIELD SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID INFRARED PHOTODETECTORS; CAPTURE; DOMAIN AB The influence of the nonuniform photogeneration on the electric-field distribution is considered for quantum-well photodetectors under drift velocity saturation. We found that spatial nonuniformity of photogenerated electrons due to attenuation of the infrared flux induces strong electric-field domains. The electric-field domains formation is accompanied by degradation of the signal-to-noise ratio. We obtained that domain structures undergo realignment at certain threshold voltage as a result of feedback influence of the quantum well recharging on the photogeneration rates which in turn cause the additional electric-field redistribution. The realignment manifests itself in a steplike change of photoconductive gain and quantum efficiency of photoabsorption at threshold bias voltage and is followed by considerable increase of generation-recombination noise. (C) 1995 American Institute of Physics. C1 USA, RES LAB, EPSD, FT MONMOUTH, NJ 07703 USA. NATL ACAD SCI, INST SEMICOND PHYS, KIEV 252650, UKRAINE. RP SHADRIN, VD (reprint author), WAYNE STATE UNIV, DEPT ELECT & COMP ENGN, DETROIT, MI 48202 USA. NR 17 TC 7 Z9 7 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD NOV 1 PY 1995 VL 78 IS 9 BP 5765 EP 5774 DI 10.1063/1.359639 PG 10 WC Physics, Applied SC Physics GA TB545 UT WOS:A1995TB54500086 ER PT J AU DANDEKAR, DP ABBATE, A FRANKEL, J AF DANDEKAR, DP ABBATE, A FRANKEL, J TI EQUATION OF STATE OF ALUMINUM NITRIDE AND ITS SHOCK RESPONSE [J-APPL-PHYS 78, 5854 (1995)] - REPLY SO JOURNAL OF APPLIED PHYSICS LA English DT Note AB This reply reinforces the need for examining the internal consistency of longitudinal and lateral stress data under plane shock wave propagation. This was pointed out in an article by Dandekar, Abbate, and Frankel [J. Appl. Phys. 76, 4077 (1994)] to determine the shear strength of a solid. It also shows that shear strength of a crystalline solid under plane shock wave compression can be determined accurately from its reliable Hugoniot and applicable hydrodynamic compression of the solid. C1 USA,ARMAMENT MUNIT & CHEM COMMAND,BENET WEAPONS LABS,WATERVLIET,NY 12189. RP DANDEKAR, DP (reprint author), USA,RES LAB,MAT DIRECTORATE,WATERTOWN,MA 02172, USA. NR 3 TC 0 Z9 0 U1 0 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD NOV 1 PY 1995 VL 78 IS 9 BP 5857 EP 5858 DI 10.1063/1.359621 PG 2 WC Physics, Applied SC Physics GA TB545 UT WOS:A1995TB54500107 ER PT J AU MONTAIN, SJ LATZKA, WA SAWKA, MN AF MONTAIN, SJ LATZKA, WA SAWKA, MN TI CONTROL OF THERMOREGULATORY SWEATING IS ALTERED BY HYDRATION LEVEL AND EXERCISE INTENSITY SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE BODY TEMPERATURE REGULATION; DEHYDRATION; HYPOHYDRATION; THERMOREGULATION ID BLOOD-VOLUME; RESPONSES; PLASMA; HYPOHYDRATION; DEHYDRATION; PERFORMANCE; HUMANS; HEAT; MEN AB The purpose of this study was to examine the thermoregulatory sweating control parameters of threshold temperature and sensitivity to determine whether 1) these variables were altered by hypohydration level and exercise intensity and 2) these alterations, if present, were additive and independent. Nine heat-acclimated men completed a matrix of nine trials: three exercise intensities of 25, 45, and 65% maximal O-2 uptake and three hydration levels, i.e., euhydration and hypohydration (Hy) at 3 and 5% of body weight. During each trial, subjects attempted 50 min of treadmill exercise in a warm room (30 degrees C dry bulb, 50% relative humidity) while esophageal temperature and upper arm sweating rate were continuously measured. Hypohydration was achieved by exercise and fluid restriction the day preceding the trials. The following new findings were made: 1) threshold temperature increased in graded manner with hypohydration level (similar to 0.06 degrees C/%Hy); 2) sensitivity decreased in a graded manner with hypohydration level (similar to 0.06 units/%Hy); 3) threshold temperature was not altered by exercise intensity; and 4) sensitivity increased from low- to moderate- and high-intensity exercise. We conclude that both hypohydration level and exercise intensity produce independent effects on control of thermoregulatory sweating. RP MONTAIN, SJ (reprint author), USA,ENVIRONM MED RES INST,DIV THERMAL PHYSIOL & MED,NATICK,MA 01760, USA. NR 27 TC 81 Z9 82 U1 0 U2 19 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD NOV PY 1995 VL 79 IS 5 BP 1434 EP 1439 PG 6 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA TD929 UT WOS:A1995TD92900007 PM 8593998 ER PT J AU GOLD, MB SCHARF, BA AF GOLD, MB SCHARF, BA TI HEMATOLOGICAL PROFILE OF THE EUTHYMIC HAIRLESS GUINEA-PIG FOLLOWING SULFUR MUSTARD VESICANT EXPOSURE SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE SULFUR MUSTARD; LEUKOCYTE; HEMATOLOGY AB Sulfur mustard (HD) is a potent vesicating agent of military importance, with known radiomimetic properties. The euthymic hairless guinea pig (EHGP) (Cavia porcellus) is emerging as the animal model of choice for cutaneous HD study. With elucidation of the systemic effects, we may better utilize this animal for all HD toxicity work. To this end, studies were conducted to determine the definitive median lethal dose (MLD) of subcutaneously applied sulfur mustard (HD) in the EHGP, and to correlate the induced hematological changes. Eight groups of two animals each were dosed at 0.3 log intervals from an extrapolated expected dose, deriving a tentative mean around which five groups of six animals each were dosed at 0.1 log intervals, resulting in a definitive MLD of 48.17 mg kg(-1). Sulfur mustard was then administered to seven groups of six animals each at a dose of 30 mg kg(-1) and hematology performed. Significant leukocyte count suppression was found to occur on days 4, 5 and 6, following a leukocyte elevation on day 1 after exposure. Serum potassium levels were found to be elevated all 7 days after HD exposure. Establishing the MLD for subcutaneously applied HD and the pattern of induced leukocyte suppression allows for more definitive evaluation of successful toxicity counter-measures. C1 USA,MED RES INST CHEM DEF,BASIC ASSESSMENT BRANCH,ABERDEEN PROVING GROUND,MD 21010. RP GOLD, MB (reprint author), USA,MED RES INST CHEM DEF,VET MED & SURG BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 18 TC 8 Z9 8 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD NOV-DEC PY 1995 VL 15 IS 6 BP 433 EP 438 DI 10.1002/jat.2550150603 PG 6 WC Toxicology SC Toxicology GA TJ586 UT WOS:A1995TJ58600002 PM 8603929 ER PT J AU HOGE, CW ECHEVERRIA, P RAJAH, R JACOBS, J MALTHOUSE, S CHAPMAN, E JIMENEZ, LM SHLIM, DR AF HOGE, CW ECHEVERRIA, P RAJAH, R JACOBS, J MALTHOUSE, S CHAPMAN, E JIMENEZ, LM SHLIM, DR TI PREVALENCE OF CYCLOSPORA SPECIES AND OTHER ENTERIC PATHOGENS AMONG CHILDREN LESS-THAN-5 YEARS OF AGE IN NEPAL SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Note ID CYANOBACTERIUM-LIKE BODIES; FOREIGN RESIDENTS; DIARRHEA; TRAVELERS; ORGANISM AB Stools from 124 Nepalese children aged 6 to 60 months with diarrhea were examined for organisms of the coccidian genus Cyclospora and for other enteric pathogens, Enterotoxigenic Escherichia coli, Giardia lamblia, Campylobacter species, Cyclospora species, and Cryptosporidium species were the most common pathogens identified. Cyclospora species were detected in none of 74 children <18 months of age compared with 6 (12%) of 50 children greater than or equal to 18 months of age (P = 0.004). C1 USA,ARMED FORCES RES INST MED SCI,MED COMPONENT,DEPT BACTERIOL IMMUNOL & MOLEC GENET,BANGKOK 10400,THAILAND. UNIV WASHINGTON,SCH PUBL HLTH & COMMUNITY MED,DEPT EPIDEMIOL,SEATTLE,WA 98195. UNIV WASHINGTON,SCH PUBL HLTH & COMMUNITY MED,INT HLTH PROGRAM,SEATTLE,WA 98195. UNIV GUADALAJARA,DEPT PUBL HLTH,GUADALAJARA 44430,JALISCO,MEXICO. TRIBHUVAN UNIV,KATMANDU,NEPAL. CIWEC CLIN,KATMANDU,NEPAL. NR 18 TC 54 Z9 60 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD NOV PY 1995 VL 33 IS 11 BP 3058 EP 3060 PG 3 WC Microbiology SC Microbiology GA TA461 UT WOS:A1995TA46100055 PM 8576377 ER PT J AU BARNHILL, DR KURMAN, RJ BRADY, MF OMURA, GA YORDAN, E GIVEN, FT KUCERA, PR ROMAN, LD AF BARNHILL, DR KURMAN, RJ BRADY, MF OMURA, GA YORDAN, E GIVEN, FT KUCERA, PR ROMAN, LD TI PRELIMINARY-ANALYSIS OF THE BEHAVIOR OF STAGE-I OVARIAN SEROUS TUMORS OF LOW MALIGNANT POTENTIAL - A GYNECOLOGIC-ONCOLOGY-GROUP STUDY SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID TERM FOLLOW-UP; BORDERLINE MALIGNANCY; EPITHELIAL TUMORS; TREATMENT MODALITIES; CARCINOMA; FEATURES AB Purpose: From December 1983 through February 1992, a prospective study designed to determine the clinical course of patients with ovarian tumors of low malignant potential (LMP) was conducted by the Gynecologic Oncology Group (GOG). Materials and Methods: This protocol was developed to evaluate he following (1) the biologic behavior of ovarian LMP tumors, (2) the effectiveness of melphalan chemotherapy in patients with clinically detectable residual disease after surgical staging and in patients whose rumors progress or recur after surgical therapy, and (3) the response rate to cisplatin in those who failed to respond to melphalan therapy, The study group consisted of 146 assessable patients with stage I serous LMP tumors. All of these women had the affected ovary (or ovaries) removed, and a complete staging operation was performed in each case, While 123 patients had a total abdominal hysterectomy (TAH) and bilateral salpingo-oophorectomy (BSO), 21 retained the uterus and one normal-appearing ovary and fallopian tube. No adjuvant chemotherapy or radiation therapy was administered to any patients in the stage I study group. Results: The median follow-up time was 42.4 months (range, 1.6 to 108), Thus for, no patient with a stage I ovarian serous LMP tumor has developed recurrent disease. Conclusion: Stage I ovarian serous LMP tumors rarely, if ever, recur. Limited resection, after meticulous surgical exploration, is adequate therapy for women of reproductive age. (C) 1995 by American Society of Clinical Oncology. C1 WALTER REED ARMY MED CTR,DEPT OBSTET & GYNECOL,GYNECOL ONCOL SERV,WASHINGTON,DC 20307. JOHNS HOPKINS MED INST,DEPT PATHOL & OBSTET & GYNECOL,BALTIMORE,MD. ROSWELL PK CANC INST,GYNECOL ONCOL GRP,BUFFALO,NY 14263. UNIV ALABAMA,DEPT MED,BIRMINGHAM,AL 35294. UNIV ALABAMA,DEPT GYNECOL,BIRMINGHAM,AL 35294. RUSH PRESBYTERIAN ST LUKES MED CTR,GYNECOL ONCOL SECT,CHICAGO,IL 60612. EASTERN VIRGINIA MED SCH,DIV GYNECOL ONCOL,NORFOLK,VA 23501. OREGON HLTH SCI UNIV,DEPT OBSTET & GYNECOL,DIV GYNECOL ONCOL,PORTLAND,OR 97201. UNIV SO CALIF,SCH MED,DEPT OBSTET & GYNECOL,DIV GYNECOL ONCOL,LOS ANGELES,CA 90033. FU NCI NIH HHS [CA 27469, CA 37517] NR 31 TC 113 Z9 114 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD NOV PY 1995 VL 13 IS 11 BP 2752 EP 2756 PG 5 WC Oncology SC Oncology GA TC986 UT WOS:A1995TC98600011 PM 7595734 ER PT J AU RINALDI, DA BURRIS, HA DORR, FA WOODWORTH, JR KUHN, JG ECKARDT, JR RODRIGUEZ, G CORSO, SW FIELDS, SM LANGLEY, C CLARK, G FARIES, D LU, P VONHOFF, DD AF RINALDI, DA BURRIS, HA DORR, FA WOODWORTH, JR KUHN, JG ECKARDT, JR RODRIGUEZ, G CORSO, SW FIELDS, SM LANGLEY, C CLARK, G FARIES, D LU, P VONHOFF, DD TI INITIAL PHASE-I EVALUATION OF THE NOVEL THYMIDYLATE SYNTHASE INHIBITOR, LY231514, USING THE MODIFIED CONTINUAL REASSESSMENT METHOD FOR DOSE SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID CLINICAL-TRIALS; INVITRO; INVIVO; DESIGN; AGENT; L1210 AB Purpose: To determine the toxicities, maximal-tolerated dose (MTD), pharmacokinetic profile, and potential antitumor activity of LY231514, a novel thymidylate synthase (TS) inhibitor. Patients and Methods: Patients with advanced solid tumors were administered LY231514 intravenously over 10 minutes, weekly for 4 weeks, every 42 days. Dose escalation was based on the modified continual reassessment method (MCRM), with one patient treated at each minimally toxic dose level. Pharmacokinetic studies were performed in all patients. Results: Twenty-five patients were administered 58 courses of LY231514 at doses that ranged from 10 to 40 mg/m(2)/wk. Reversible neutropenia wets the dose-limiting toxicity. Inability to maintain the weekly treatment schedule due to neutropenia limited dose escalation on this schedule. Nonhematologic toxicities observed included mild fatigue, anorexia, and nausea. At the 40-mg/m(2)/wk dose level, the mean harmonic half-life, maximum plasma concentration, clearance, and apparent volume of distribution at steady-state were 2.02 hours, 11.20 mu g/mL, 52.3 mL/min/m(2), and 6.64 L/m(2), respectively. No major antitumor responses were ob served; however, minor responses were achieved in two patients with advanced colorectal cancer. Conclusion: The dose-limiting toxicity, MTD, and recommended phase II dose of LY231514 when administered weekly for 4 weeks every 42 days are neutropenia, 40 mg/m(2), and 30 mg/m(2), respectively. (C) 1995 by American Society of Clinical Oncology. C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX. UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX. ELI LILLY & CO,INDIANAPOLIS,IN. RP RINALDI, DA (reprint author), CANC THERAPY & RES CTR S TEXAS,INST DRUG DEV,8122 DATAPOINT DR,SUITE 1000,SAN ANTONIO,TX 78229, USA. NR 14 TC 135 Z9 139 U1 1 U2 2 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD NOV PY 1995 VL 13 IS 11 BP 2842 EP 2850 PG 9 WC Oncology SC Oncology GA TC986 UT WOS:A1995TC98600024 PM 7595747 ER PT J AU Gawlik, JA Ott, NW Mathieu, GP AF Gawlik, JA Ott, NW Mathieu, GP TI Modifications of the palatal crib habit-breaker appliance to prevent palatal soft tissue embedment SO JOURNAL OF DENTISTRY FOR CHILDREN LA English DT Article DE palatal crib; modification ID ORAL HABITS; MANAGEMENT AB The authors recommend the use of an acrylic palatal button and .040 to .045 inch palatal wires as modifications to the palatal crib appliance. By enhancing the strength of the wire, and providing anterior support, these modifications can reduce the likelihood of the crib becoming embedded in the palatal soft tissues. C1 USA, VICENZA, ITALY. USA, PEDIAT DENT RESIDENCY PROGRAM, FT GEORGE G MEADE, MD USA. NR 20 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC DENTISTRY CHILD PI CHICAGO PA 211 E CHICAGO AVE, CHICAGO, IL 60611 SN 0022-0353 J9 J DENT CHILD JI J. Dent. Child. PD NOV-DEC PY 1995 VL 62 IS 6 BP 409 EP + PG 4 WC Dentistry, Oral Surgery & Medicine; Pediatrics SC Dentistry, Oral Surgery & Medicine; Pediatrics GA TQ851 UT WOS:A1995TQ85100009 ER PT J AU JONES, KA LAREAU, RT MONAHAN, T FLEMISH, JR PFEFFER, RL SHERRIFF, RE LITTON, CW JONES, RL STUTZ, CE LOOK, DC AF JONES, KA LAREAU, RT MONAHAN, T FLEMISH, JR PFEFFER, RL SHERRIFF, RE LITTON, CW JONES, RL STUTZ, CE LOOK, DC TI COMPARISON OF OMVPE GROWN GAAS/ALGAAS AND GAAS/INGAP HEMT AND PHEMT STRUCTURES SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 7th Biennial Workshop on Organometallic Vapor Phase Epitaxy CY APR 02-06, 1995 CL FT MYERS, FL SP Air Prod & Chem Inc, Aixtron Inc, Akzo Nobel Chem Inc, EMCORE Corp, Epitaxial Prod Int ltd, MCP Wafer Technol Ltd, MKS Instruments, Morton Int, NIMTEC Inc, Japan Energy Corp, Rockwell Int, Solkatron Chem, Thomas Swann & Co Ltd, Sci Equipment Div DE GAAS/ALGAAS; GAAS/INGAP; HIGH ELECTRON MOBILITY TRANSISTOR (HEMT); PSEUDO-MORPHIC HIGH ELECTRON MOBILITY TRANSISTOR (PHEMT); ORGANOMETALLIC VAPOR PHASE EPITAXY (OMVPE) ID CHEMICAL VAPOR-DEPOSITION; PSEUDOMORPHIC HEMT; MOVPE; HETEROSTRUCTURES; PRESSURE; GAAS; LSIS; TEMPERATURE; UNIFORM; QUALITY AB Symmetric delta-doped InGaP and AlGaAs PHEMT structures have been grown by organometallic vapor phase epitaxy with properties that approach those of MBE grown AlGaAs structures. The 300 and 77K carrier concentrations for the InGaP PHEMT were 2.72 and 2.56 x 10(12) cm(-2) and the mobilities were 5,920 and 22,000 cm(2)/V . s. These excellent values suggest that problems associated with switching the anion at the channel heterojunction have been overcome. The corresponding values for the AlGaAs PHEMT were 2.51 and 2.19 x 10(12) cm(-2) and 6,500 and 20,400 cm(2)/V . s. The uniformity in the indium concentration in the InGaAs layer as determined by photoluminescence, photoreflection, double crystal x-ray diffraction, and Rutherford backscattering was found to be good, but the percent In in the AlGaAs pseudo-morphic high electron mobility transistor (PHEMT) was less than that in the InGaP PHEMT even though the programmed values were the same. The uniformity in the doping distribution as determined by secondary ion mass spectroscopy and electrochemical capacitance-voltage measurements was found to be good, but it decreased with distance from the center of the susceptor. Also, most of the dopants in the delta-doped InGaP and AlGaAs layers were activated. C1 USAF,WRIGHT LAB,ELR,WRIGHT PATTERSON AFB,OH 45433. WRIGHT STATE UNIV,DAYTON,OH 45435. RP JONES, KA (reprint author), USA,RES LAB,AMSRC,EP,EC,FT MONMOUTH,NJ 07703, USA. NR 26 TC 1 Z9 1 U1 0 U2 1 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 420 COMMONWEALTH DR, WARRENDALE, PA 15086 SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD NOV PY 1995 VL 24 IS 11 BP 1641 EP 1648 DI 10.1007/BF02676825 PG 8 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA TE167 UT WOS:A1995TE16700023 ER PT J AU CZERW, RJ FULKERSON, MS DONNELLY, JC WALMANN, JO AF CZERW, RJ FULKERSON, MS DONNELLY, JC WALMANN, JO TI IN-VITRO EVALUATION OF THE ACCURACY OF SEVERAL ELECTRONIC APEX LOCATORS SO JOURNAL OF ENDODONTICS LA English DT Article ID FORAMEN AB This study describes two tests of the in vitro accuracy of several models of electronic canal length measuring devices (ECLMD's) using a gelatin test model and extracted human teeth with fully formed apices. In part 1, four previously untested ECLMD's were used in dry canals after access and pulpectomy. File lengths with the file tip just visible at the foramen were compared to ECLMD lengths. Clinically significant ECLMD measurements of greater than or equal to 0.5 mm than visual length were noted with two ECLMD's 16.6% and 10% of the time. The other two ECLMD's had no measurements >0.5 mm than the visual measurement. The gelatin test model proved highly accurate with 4 of 6 ECLMD's tested thus far. Part 2 compared the accuracy of a previously tested ECLMD using the gelatin model when taking length measurements with canals both dry and wet with distilled water in them. There was no difference between measurements in wet or dry canals. Irrigation with distilled water may be a clinical aid when using resistance ECLMD's. C1 USA,DENT ACTIV,FT HOOD,TX 76544. PERSCOM,ALEXANDRIA,VA. NR 10 TC 37 Z9 39 U1 0 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD NOV PY 1995 VL 21 IS 11 BP 572 EP 575 DI 10.1016/S0099-2399(06)80988-X PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA TB388 UT WOS:A1995TB38800009 PM 8601769 ER PT J AU WIZEL, B HOUGHTEN, RA PARKER, KC COLIGAN, JE CHURCH, P GORDON, DM BALLOU, WR HOFFMAN, SL AF WIZEL, B HOUGHTEN, RA PARKER, KC COLIGAN, JE CHURCH, P GORDON, DM BALLOU, WR HOFFMAN, SL TI IRRADIATED SPOROZOITE VACCINE INDUCES HLA-B8-RESTRICTED CYTOTOXIC T-LYMPHOCYTE RESPONSES AGAINST 2 OVERLAPPING EPITOPES OF THE PLASMODIUM-FALCIPARUM SPOROZOITE SURFACE PROTEIN-2 SO JOURNAL OF EXPERIMENTAL MEDICINE LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; HUMAN MALARIA PARASITE; CIRCUMSPOROZOITE PROTEIN; PEPTIDE BINDING; CELL EPITOPES; ANCHOR RESIDUES; SPECIFICITY; MOLECULES; SEQUENCE; ANTIGEN AB Vaccines designed to protect against malaria by inducing CD8(+) cytotoxic T lymphocytes (CTL) in individuals of diverse HLA backgrounds must contain multiple conserved epitopes from various preerythrocytic-stage antigens. Plasmodium falciparum sporozoite surface protein 2 (PfSSP2) is considered an important antigen for inclusion in such vaccines, because CD8(+) CTL against the P. yoelii SSP2 protect mice against malaria by eliminating infected hepatocytes. To develop PfSSP2 as a component of malaria vaccines, we investigated the presence of anti-PfSSP2 CTL in two HLA-B8(+) volunteers immunized with irradiated P. falciparum sporozoites and characterized their CTL responses using PfSSP2-derived 15-amino acid peptides bearing the HLA-B8-binding motif. Peripheral blood mononuclear cells from both volunteers stimulated with recombinant vaccinia expressing PfSSP2 displayed antigen-specific, genetically restricted, CD8(+) T cell-dependent CTL activity against autologous target cells expressing PfSSP2. Of the five HLA-B8 motif-bearing 15-mers identified in the PfSSP2 sequence, two peptides sharing a 10-amino acid overlap sensitized HLA-B8-matched target cells from both volunteers for lysis by peptide-stimulated effector;. The CTL activity was HLA-B8 restricted and dependent on CD8(+) T cells. Analysis of the three shorter peptides representing HLA-B8 motif-bearing sequences within the two positive peptides for their ability to bind to HLA-B8 in vitro, and to sensitize target cells for lysis by effecters stimulated with the 15-mers, identified two overlapping HLA-B8-restricted CTL epitopes. Available data indicate that the sequence of one CTL epitope is conserved and the other is variant among P. falciparum isolates. Circulating activated CTL against the conserved epitope could be directly identified in one of the two volunteers. The identification of two HLA-B8-restricted CTL epitopes on PfSSP2 provides data critical to developing an epitope-based anti-liver stage malaria vaccine. C1 USN,MED RES INST,MALARIA PROGRAM,BETHESDA,MD 20889. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT MOLEC MICROBIOL & IMMUNOL,BALTIMORE,MD 21205. TORREY PINES INST MOLEC STUDIES,SAN DIEGO,CA 92121. HOUGHTEN PHARMACEUT INC,SAN DIEGO,CA 92121. NIAID,MOLEC STRUCT LAB,ROCKVILLE,MD 20852. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307. OI Parker, Kenneth/0000-0002-6282-2478 NR 64 TC 66 Z9 66 U1 0 U2 0 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0022-1007 J9 J EXP MED JI J. Exp. Med. PD NOV 1 PY 1995 VL 182 IS 5 BP 1435 EP 1445 DI 10.1084/jem.182.5.1435 PG 11 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA TB894 UT WOS:A1995TB89400026 PM 7595214 ER PT J AU AVSICZUPANC, T TONEY, A ANDERSON, K CHU, YK SCHMALJOHN, C AF AVSICZUPANC, T TONEY, A ANDERSON, K CHU, YK SCHMALJOHN, C TI GENETIC AND ANTIGENIC PROPERTIES OF DOBRAVA-VIRUS - A UNIQUE MEMBER OF THE HANTAVIRUS GENUS, FAMILY BUNYAVIRIDAE SO JOURNAL OF GENERAL VIROLOGY LA English DT Article ID NUCLEOTIDE-SEQUENCE ANALYSIS; PROSPECT-HILL VIRUS; HEMORRHAGIC-FEVER; RENAL SYNDROME; HANTAAN VIRUS; MOLECULAR CHARACTERIZATION; CODING STRATEGY; GENOME SEGMENT; S-GENOME; RNA AB We examined the genetic and antigenic properties of Dobrava (DOE) virus, a hantavirus associated with severe haemorrhagic fever with renal syndrome in Europe. Cloning and sequence analyses revealed the DOB M segment to consist of 3644 nucleotides, with a coding capacity of 1134 amino acids in the virus complementary-sense RNA (cRNA). Seven potential asparagine-linked glycosylation sites were identified in the M segment gene product, one in the G2 and six in the G1 coding regions. The S segment is 1667 nucleotides long, and has a single ORF in the cRNA capable of encoding a protein of 428 amino acids. Phylogenetic comparisons of the M and S segments of DOB virus to those of other hantaviruses indicated that DOB virus is similar to, but clearly distinct from Hantaan (HTN) and Seoul (SEO) viruses. Certain G2-specific, but not G1-specific monoclonal antibodies to HTN virus reacted to the same titre with DOB and homologous viral antigen. Plaque-reduction neutralization tests indicated that, of the sera tested, only antisera to SEO virus were able to neutralize DOB virus to a titre greater than 1:10; however, this neutralization titre was eightfold lower than that observed with homologous SEO virus. The data reported here confirm that DOB virus is a unique species in the Hantavirus genus, family Bunyaviridae. C1 USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21702. NR 34 TC 78 Z9 80 U1 0 U2 2 PU SOC GENERAL MICROBIOLOGY PI READING PA HARVEST HOUSE 62 LONDON ROAD, READING, BERKS, ENGLAND RG1 5AS SN 0022-1317 J9 J GEN VIROL JI J. Gen. Virol. PD NOV PY 1995 VL 76 BP 2801 EP 2808 DI 10.1099/0022-1317-76-11-2801 PN 11 PG 8 WC Biotechnology & Applied Microbiology; Virology SC Biotechnology & Applied Microbiology; Virology GA TC058 UT WOS:A1995TC05800018 PM 7595387 ER PT J AU ZELENKA, RE YEE, Z ZIRKLER, A AF ZELENKA, RE YEE, Z ZIRKLER, A TI FLIGHT TEST OF RADAR ALTIMETER ENHANCEMENT FOR TERRAIN-REFERENCED GUIDANCE (VOL 18, PG 706, 1995) SO JOURNAL OF GUIDANCE CONTROL AND DYNAMICS LA English DT Correction, Addition C1 USA,COMMAND CONTROL & SYST INTEGRAT DIRECTORATE,FT MONMOUTH,NJ 07703. VITRON INC,EATONTOWN,NJ 07724. RP ZELENKA, RE (reprint author), NASA,AMES RES CTR,MOFFETT FIELD,CA 94035, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0731-5090 J9 J GUID CONTROL DYNAM JI J. Guid. Control Dyn. PD NOV-DEC PY 1995 VL 18 IS 6 BP 1470 EP 1470 DI 10.2514/3.56692 PG 1 WC Engineering, Aerospace; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA TE758 UT WOS:A1995TE75800040 ER PT J AU SABOL, BM HUDSON, MK AF SABOL, BM HUDSON, MK TI TECHNIQUE USING THERMAL INFRARED-IMAGING FOR ESTIMATING POPULATIONS OF GRAY BATS SO JOURNAL OF MAMMALOGY LA English DT Article DE BATS; DIGITAL PICTURE PROCESSING; POPULATION ESTIMATION; THERMAL INFRARED IMAGING AB Estimating size of populations of bats during nocturnal emergence from caves relies on techniques of visual counting that are subjective and highly dependent on skill of the observer. A noninvasive technique, using thermal infrared-imaging and digital picture processing, was developed and tested at two caves in northern Alabama. A comparison of estimates between this technique and that of a skilled observer with a night-vision scope revealed a difference of <6%. This semi-automated technique and its applicability are discussed. C1 ALABAMA DEPT CONSERVAT & NAT RESOURCES,DIV GAME & FISH,NONGAME WILDLIFE PROGRAM,MONTGOMERY,AL 36130. RP SABOL, BM (reprint author), USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180, USA. NR 5 TC 22 Z9 23 U1 1 U2 6 PU AMER SOC MAMMALOGISTS PI PROVO PA BRIGHAM YOUNG UNIV, DEPT OF ZOOLOGY, PROVO, UT 84602 SN 0022-2372 J9 J MAMMAL JI J. Mammal. PD NOV PY 1995 VL 76 IS 4 BP 1242 EP 1248 DI 10.2307/1382618 PG 7 WC Zoology SC Zoology GA TJ248 UT WOS:A1995TJ24800027 ER PT J AU WENSING, MW SNYDER, AP HARDEN, CS AF WENSING, MW SNYDER, AP HARDEN, CS TI ENERGY-RESOLVED MASS-SPECTROMETRY OF DIETHYL ALKYL PHOSPHONATES WITH AN ATMOSPHERIC-PRESSURE IONIZATION TANDEM MASS-SPECTROMETER SO JOURNAL OF MASS SPECTROMETRY LA English DT Article DE ORGANOPHOSPHORUS COMPOUNDS; ATMOSPHERIC PRESSURE IONIZATION; COLLISIONALLY ACTIVATED DISSOCIATION; TANDEM MASS SPECTROMETRY ID COLLISION-INDUCED DISSOCIATION; ELECTROSPRAY IONIZATION; TRIPLE QUADRUPOLES; ORGANOPHOSPHORUS COMPOUNDS; FRAGMENTATION MECHANISMS; IONS; H2O AB Energy resolved mass spectrometry (ERMS) was used to characterize the dissociation processes of four diethyl alkyl phosphonates where the alkyl R group attached to the central phosphorus atom ranged from methyl to n-butyl. An atmospheric pressure ionization triple quadrupole mass spectrometer was used in the analyses. Dissociation of the MH(+) and further dissociation of the resulting progeny ions was induced between the atmospheric-vacuum sampling orifice and the first ion focusing RF-only quadrupole, Q0, instead of the central Q2 quadrupole. The major dissociation pathways of the four phosphonates could be characterized by two sequential McLafferty rearrangements yielding an alkyl phosphonic acid. This acid further dissociated losing H2O followed by ROH to produce PO+, or the same process occurred but in the reverse order, i.e. first losing ROH followed by H2O to yield PO+. The latter process was the energetically favored process. The alkyl group attached to the phosphorus atom of the protonated alkyl phosphonic acid was observed to have a significant influence on the stability of the protonated alkyl phosphonic acid. As the R group increased in size with a concomitant increase in electron-donating power, the alkyl phosphonic acid was less prone to dissociation than other alkyl phosphonic acids which possessed smaller R groups. A significant difference was also noted in the alkyl phosphonic acid dissociation processes; methyl phosphonic acid dissociated predominantly via H2O loss unlike the other acids which favored the loss of ROH over H2O. C1 CTR DEV & ENGN,EDGEWOOD RES,ABERDEEN PROVING GROUND,MD 21010. RP WENSING, MW (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 23 TC 14 Z9 14 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 1076-5174 J9 J MASS SPECTROM JI J. Mass Spectrom. PD NOV PY 1995 VL 30 IS 11 BP 1539 EP 1545 DI 10.1002/jms.1190301104 PG 7 WC Biophysics; Chemistry, Organic; Spectroscopy SC Biophysics; Chemistry; Spectroscopy GA TF185 UT WOS:A1995TF18500003 ER PT J AU DOHM, DJ LOGAN, TM BARTH, JF TURELL, MJ AF DOHM, DJ LOGAN, TM BARTH, JF TURELL, MJ TI LABORATORY TRANSMISSION OF SINDBIS-VIRUS BY AEDES-ALBOPICTUS, AEDES-AEGYPTI, AND CULEX-PIPIENS (DIPTERA, CULICIDAE) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE AEDES ALBOPICTUS; SINDBIS VIRUS; TRANSMISSION ID VALLEY FEVER VIRUS; OCKELBO VIRUS; UNITED-STATES; SWEDEN; DISEASE; STRAINS; ARBOVIRUSES; MOSQUITOS; LOUISIANA; AFRICA AB The susceptibility of Aedes albopictus (Skuse) for Sindbis (SIN) virus was examined in the laboratory. Ae. albopictus, Ae. aegypti (L.), and Culex pipiens (L.) became infected with and subsequently transmitted SIN virus by bite to chicks after feeding on viremic 1-d-old chicks. After ingesting 10(5.3) plaque-forming units (PFU)/ml, Ae. albopictus had the highest transmission rate (30%) of the 3 species. Transmission by Ae. aegypti was less efficient (7%), whereas none of the Cx. pipiens transmitted virus. Transmission rates were higher for Ae. albopictus (53%) and Cx. pipiens (37%) when they fed on chicks with a viremia of 10(8.4) PFU/ml. Ae. aegypti was not tested at this dose. Based on these studies, the increased geographic distribution of Ae. albopictus, and its opportunistic feeding behavior, this species should be considered as a potential bridge vector of SIN virus. RP DOHM, DJ (reprint author), USA,MED RES INST INFECT DIS,DEPT EPIDEMIOL,DIV APPL RES,FT DETRICK,FREDERICK,MD 21702, USA. NR 34 TC 12 Z9 13 U1 0 U2 0 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD NOV PY 1995 VL 32 IS 6 BP 818 EP 821 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA TC133 UT WOS:A1995TC13300008 PM 8551504 ER PT J AU SOLBERG, VB KLEIN, TA MCPHERSON, KR BRADFORD, BA BURGE, JR WIRTZ, RA AF SOLBERG, VB KLEIN, TA MCPHERSON, KR BRADFORD, BA BURGE, JR WIRTZ, RA TI FIELD-EVALUATION OF DEET AND A PIPERIDINE REPELLENT (AI3-37220) AGAINST AMBLYOMMA-AMERICANUM (ACARI, IXODIDAE) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE AMBLYOMMA AMERICANUM; TICKS; REPELLENTS; DEET; AI3-37220; PIPERIDINE ID IXODES-DAMMINI; TICKS; TOXICANT AB Repellent efficacy of deet (N,N-diethyl-3-methylbenzamide) and a piperidine, AI3-37220, was evaluated topically on human volunteers against lone star tick, Amblyomma americanum (L.), nymphs and adults in the field. AI3-37220, at 0.5 mg/cm(2), provided >90% repellency against adult and nymphal ticks over a 6-h test period and showed significantly better repellent efficacy than deet. Deet, at the same concentration, provided 85% repellency at 0 h and deteriorated to 55% repellency at 6 h. C1 PREVENT MED SERV,FT MONMOUTH,NJ 07703. WALTER REED ARMY INST RES,DIV BIOMETR,WASHINGTON,DC 20307. RP SOLBERG, VB (reprint author), WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307, USA. NR 13 TC 43 Z9 44 U1 1 U2 6 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD NOV PY 1995 VL 32 IS 6 BP 870 EP 875 PG 6 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA TC133 UT WOS:A1995TC13300016 PM 8551512 ER PT J AU ASHER, LVS BINN, LN MENSING, TL MARCHWICKI, RH VASSELL, RA YOUNG, GD AF ASHER, LVS BINN, LN MENSING, TL MARCHWICKI, RH VASSELL, RA YOUNG, GD TI PATHOGENESIS OF HEPATITIS-A IN ORALLY INOCULATED OWL MONKEYS (AOTUS-TRIVIRGATUS) SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE HEPATITIS A; PATHOGENESIS; OWL MONKEYS ID A VIRUS; EXPERIMENTAL-INFECTION; CELL-CULTURES; REPLICATION AB The pathogenesis of hepatitis A virus (HAV) infection was studied in owl monkeys following oral administration of the wild-type HM-175 strain of HAV. Stools were collected daily and blood and pharyngeal swabs twice weekly for viral isolation, and animals were necropsied at various intervals after inoculation. Organs were examined for the presence of virus by isolation in cell culture and for viral antigens by immunofluorescence. Monkeys excreted HAV in the stools for 1-4 days after inoculation, presumably due to the residual unabsorbed inoculum. No virus was found in stools for the next 2-3 days. HAV re-appeared on days 4-7 and then persisted through day 39. Viremia occurred on the 10th day and continued until day 35. Virus was isolated occasionally from throat swabs 1 or 2 weeks after it was detected in stools and blood, and there was no evidence that HAV replicated in the pharyngeal tissues. Animals acquired anti-HAV antibody by the 4th week, and alanine aminotransferase (ALT) was elevated 5-5.5 weeks after inoculation. HAV was isolated from liver 5 days after inoculation; however, viral antigens were first detected in Kupffer cells of the liver at 14 days and in hepatocytes at 21 days. HAV antigen was detected in epithelial cells of the intestinal crypts and in the cells of the lamina propria of the small intestine 3 days postinoculation and thereafter until the 5th week, suggesting that these cells might represent an additional site of HAV replication. (C) 1995 Wiley-Liss, Inc. C1 WALTER REED ARMY INST RES,DEPT COMPARAT PATHOL,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DEPT VIRUS DIS,WASHINGTON,DC 20307. RP ASHER, LVS (reprint author), WALTER REED ARMY INST RES,DEPT EXPTL PATHOL,DIV PATHOL,WASHINGTON,DC 20307, USA. NR 32 TC 58 Z9 60 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0146-6615 J9 J MED VIROL JI J. Med. Virol. PD NOV PY 1995 VL 47 IS 3 BP 260 EP 268 DI 10.1002/jmv.1890470312 PG 9 WC Virology SC Virology GA TB762 UT WOS:A1995TB76200011 PM 8551278 ER PT J AU Owens, PM Loehle, DW Scott, BS Gonzalez, RS AF Owens, PM Loehle, DW Scott, BS Gonzalez, RS TI Parallel column gas chromatography SO JOURNAL OF MICROCOLUMN SEPARATIONS LA English DT Article; Proceedings Paper CT 17th International Symposium on Capillary Chromatography and Electrophoresis CY MAY, 1995 CL WINTERGREEN, VA DE gas chromatography (GC); multidimensional chromatography (MDC); parallel column gas chromatography (PCGC); thermodynamic retention parameters ID CHLORINATED PESTICIDES; RETENTION INDEXES; SIMULATION; DETECTOR AB A parallel column gas chromatography (PCGC) methodology that simultaneously collects retention information on multiple stationary phases is presented. The multidimensional PCGC configuration links a precolumn in series with a set of parallel analytical columns (having different stationary phases) all connected to a single detector. GC peaks heartcut from the precolumn are detected as a series of peaks due to retention differences on parallel columns. This provides a GC retention pattern that is characteristic of the analyte, the stationary phase array, and the conditions of the analysis. PCGC peak patterns observed for groups of C8, C9, and C10 compounds are presented. The use of PCGC with infrared and mass spectral detectors is reported. A methodology to account for changes in GC operating parameters using relative retentions of analytes to internal standards is presented. The first use of thermodynamic retention parameters to model retention behavior on parallel analytical columns under different temperature profiles is presented. Retention predictions within 0.3-0.6% of experimental values are reported. These results indicate that PCGC has potential as a general qualitative analysis tool. Future efforts to calibrate retention predictions, to transport PCGC results between instruments, and to optimize the number of parallel columns are proposed. (C) 1995 John Wiley & Sons, Inc. C1 US MIL ACAD,CTR MOLEC SCI,W POINT,NY 10996. NR 21 TC 5 Z9 5 U1 0 U2 2 PU MICROSEPARATIONS INC PI PROVO PA DEPT CHEM BRIGHAM YOUNG UNIV, PROVO, UT 84602-1022 SN 1040-7685 J9 J MICROCOLUMN SEP JI J. Microcolumn Sep. PD NOV-DEC PY 1995 VL 7 IS 6 BP 551 EP 566 DI 10.1002/mcs.1220070602 PG 16 WC Chemistry, Analytical SC Chemistry GA TK553 UT WOS:A1995TK55300001 ER PT J AU MCCARROLL, JE URSANO, RJ FULLERTON, CS LUNDY, A AF MCCARROLL, JE URSANO, RJ FULLERTON, CS LUNDY, A TI ANTICIPATORY STRESS OF HANDLING HUMAN REMAINS FROM THE PERSIAN-GULF-WAR - PREDICTORS OF INTRUSION AND AVOIDANCE SO JOURNAL OF NERVOUS AND MENTAL DISEASE LA English DT Article ID BLOOD INJURY FEAR; EVENT SCALE; DISASTER; IMPACT; DEAD; VALIDATION; EXPOSURE; DISORDER; RECOVERY AB High levels of distress were found in military mortuary workers prior to the arrival of the human remains from the Persian Gulf War of 1991. To better understand the stress of anticipating the handling of remains, we performed stepwise multiple regression analyses to identify the best predictors of intrusive thoughts and avoidant thoughts and behavior, two of the primary symptoms of posttraumatic stress disorder. After volunteer status and sex were controlled, fear and discomfort with mutilation and the grotesque, as measured by the Mutilation Questionnaire, and defensiveness or denial, as measured by the Marlowe-Crowne Scale, were significant predictors of intrusion and avoidance in the inexperienced group. In the experienced group, only the Mutilation Questionnaire predicted intrusion and avoidance. Results have implications for selection, training, and interventions for mortuary workers and other disaster workers whose job includes exposure to human remains. C1 UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,DEPT PSYCHIAT,BETHESDA,MD 20814. JEFFERSON MED COLL,DEPT PSYCHIAT & HUMAN BEHAV,PHILADELPHIA,PA. RP MCCARROLL, JE (reprint author), WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307, USA. NR 27 TC 7 Z9 7 U1 2 U2 5 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3018 J9 J NERV MENT DIS JI J. Nerv. Ment. Dis. PD NOV PY 1995 VL 183 IS 11 BP 698 EP 703 DI 10.1097/00005053-199511000-00005 PG 6 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA TE753 UT WOS:A1995TE75300005 PM 7595432 ER PT J AU PEACOCK, ME CARSON, RE AF PEACOCK, ME CARSON, RE TI FREQUENCY OF SELF-REPORTED MEDICAL CONDITIONS IN PERIODONTAL PATIENTS SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE AGED; MEDICAL HISTORY; MEDICAL RECORDS; RISK FACTORS; DELIVERY OF HEALTH CARE; DENTAL CARE ID SYSTEMIC CONDITIONS; DIABETES-MELLITUS; DENTISTRY; DISEASE AB ASSESSING THE MEDICAL HISTORY Of patients before any treatment is provided is an essential aspect of the periodontist's responsibility. A patient's compromised medical state could alter the response to periodontal treatment or worse, contribute to a crisis situation that may prove harmful to his or her well-being. This study examines the frequency of medical conditions in periodontal patients utilizing a self-administered health questionnaire succeeded by directly interviewing the patient for validity. Health histories were taken from 590 periodontal patients in an outpatient setting; 52.5% of these patients reported a positive finding in their medical history, with drug allergies and cardiovascular disorders being by far the most frequently found conditions. The frequency of medical conditions increased with increasing age. Thorough evaluation of a patient's health history is a mandatory first step in the treatment process. C1 UNIV OKLAHOMA,OKLAHOMA CITY,OK. RP PEACOCK, ME (reprint author), USA,DENT ACTIV,FT POLK,LA 71459, USA. NR 20 TC 13 Z9 13 U1 0 U2 2 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD NOV PY 1995 VL 66 IS 11 BP 1004 EP 1007 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA TF549 UT WOS:A1995TF54900012 PM 8558389 ER PT J AU Sliney, DH AF Sliney, DH TI UV radiation ocular exposure dosimetry SO JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY LA English DT Article; Proceedings Paper CT International Workshop on Biological UV Dosimetry CY NOV 29-DEC 03, 1994 CL BUDAPEST, HUNGARY DE UV radiation; eye; cataract; UV dosimetry ID ULTRAVIOLET-RADIATION; LIGHT; TISSUES; EYE AB There is currently some degree of controversy as to the magnitude of cataract and other ocular diseases related to human lifetime exposure to UV radiation (UVR). Concerns about the depletion of stratospheric ozone and the related increase in terrestrial UVR exposure have emphasized the importance of resolving this controversy. A careful study of ocular exposure to environmental sunlight demonstrates that it is not simple to determine accurately the level of solar UVR exposure of the human eye. Past attempts to measure or calculate UVR exposure of the eye have generally relied on the measurement of ambient UVR in sunlight with global monitors. Unfortunately, such attempts have seldom assessed properly the large role of ground reflection, the horizon sky contribution, the degree of lid opening and the extreme lateral component of UVR incident on the eye. A series of recent ocular dosimetry studies are described which have considered all of these factors. In addition, the value of different types of eye protection is shown to vary widely depending on the frame design. The dosimetry studies can be confirmed by a biological dosimeter-the human cornea. Because the action spectrum and threshold for human photokeratitis are well defined, the living cornea can serve as a biological dosimeter for ocular exposure. RP Sliney, DH (reprint author), USA,CTR HLTH PROMOT & PREVENT MED,CHIEF LASER BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 32 TC 51 Z9 54 U1 0 U2 4 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 1011-1344 J9 J PHOTOCH PHOTOBIO B JI J. Photochem. Photobiol. B-Biol. PD NOV PY 1995 VL 31 IS 1-2 BP 69 EP 77 DI 10.1016/1011-1344(95)07171-5 PG 9 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA TK775 UT WOS:A1995TK77500012 PM 8568605 ER PT J AU DORFF, RH AF DORFF, RH TI FATHERS OF INTERNATIONAL THOUGHT - THE LEGACY OF POLITICAL-THEORY - THOMPSON,KW SO JOURNAL OF POLITICS LA English DT Book Review C1 USA,COLL WAR,WASHINGTON,DC 20310. RP DORFF, RH (reprint author), N CAROLINA STATE UNIV,RALEIGH,NC 27695, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV TEXAS PRESS PI AUSTIN PA BOX 7819, AUSTIN, TX 78713-7819 SN 0022-3816 J9 J POLIT JI J. Polit. PD NOV PY 1995 VL 57 IS 4 BP 1224 EP 1226 DI 10.2307/2960429 PG 3 WC Political Science SC Government & Law GA TF527 UT WOS:A1995TF52700046 ER PT J AU LIBERATORE, F AF LIBERATORE, F TI ONE-DIMENSIONAL, EQUILIBRIUM-CHEMISTRY RAM ACCELERATOR PERFORMANCE CALCULATIONS SO JOURNAL OF PROPULSION AND POWER LA English DT Note RP LIBERATORE, F (reprint author), USA,RES LAB,WEAPONS TECHNOL DIRECTORATE,PROP BRANCH,MS AMSRL WT PA,ABERDEEN PROVING GROUND,MD 21005, USA. NR 7 TC 4 Z9 4 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0748-4658 J9 J PROPUL POWER JI J. Propul. Power PD NOV-DEC PY 1995 VL 11 IS 6 BP 1366 EP 1368 DI 10.2514/3.23981 PG 3 WC Engineering, Aerospace SC Engineering GA TF316 UT WOS:A1995TF31600036 ER PT J AU Schmidt, JJ Bostian, KA AF Schmidt, JJ Bostian, KA TI Proteolysis of synthetic peptides by type A botulinum neurotoxin SO JOURNAL OF PROTEIN CHEMISTRY LA English DT Article DE botulinum toxin; peptide proteolysis ID NEUROTRANSMITTER RELEASE; TETANUS TOXIN; PROTEIN; IDENTIFICATION; CLEAVAGE; SNAP-25; ZINC AB Type A botulinum neurotoxin catalyzed the hydrolysis of synthetic peptides based on the sequence of the 25-kD synaptosomal protein SNAP-25. In each peptide, the toxin cleaved at a single glutaminyl-arginine bond corresponding to residues 197 and 198 of SNAP-25, confirming earlier reports on the enzymatic specificity of the toxin in synaptosomaI preparations. Metal chelators inhibited catalysis, consistent with a metalloprotease activity. In contrast to tetanus toxin and other botulinum toxin serotypes, type A toxin hydrolyzed relatively short, 17- to 20-residue peptides. In the substrates, SNAP-25 residue 202 and one or more of residues 187-191 were required for efficient hydrolysis, but residues 167-186 and 203-206 were not. The highest rates of hydrolysis were found when the C-terminal residues of the peptides were amidated. RP Schmidt, JJ (reprint author), USA,MED RES INST INFECT DIS,TOXINOL DIV,FREDERICK,MD 21702, USA. NR 22 TC 107 Z9 107 U1 0 U2 3 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0277-8033 J9 J PROTEIN CHEM JI J. Protein Chem. PD NOV PY 1995 VL 14 IS 8 BP 703 EP 708 DI 10.1007/BF01886909 PG 6 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA TM175 UT WOS:A1995TM17500008 PM 8747431 ER PT J AU FINGER, DR KLIPPLE, GL AF FINGER, DR KLIPPLE, GL TI GYNECOMASTIA AFTER LOW-DOSE METHOTREXATE THERAPY FOR RHEUMATOID-ARTHRITIS - REPLY SO JOURNAL OF RHEUMATOLOGY LA English DT Letter C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP FINGER, DR (reprint author), WILLIAM BEAUMONT ARMY MED CTR,EL PASO,TX 79920, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU J RHEUMATOL PUBL CO PI TORONTO PA 920 YONGE ST, SUITE 115, TORONTO ON M4W 3C7, CANADA SN 0315-162X J9 J RHEUMATOL JI J. Rheumatol. PD NOV PY 1995 VL 22 IS 11 BP 2189 EP 2189 PG 1 WC Rheumatology SC Rheumatology GA TC847 UT WOS:A1995TC84700043 ER PT J AU Mikhail, AG AF Mikhail, AG TI Roll damping for projectiles including wraparound, offset, and arbitrary number of fins SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article AB An algebraic correlation for the roll-damping and roll-producing moments for finned projectiles and missiles has been extended and verified to accept bodies with an arbitrary number of fins-not only cruciform fins, but curved wraparound fins with fin cant, and fins with offset angles. The extended correlation is applicable at subsonic, transonic, and supersonic speeds. A direct method to compute the fin roll-producing moment from the fin normal force is provided to circumvent the existing lengthy and cumbersome semiempirical methods. Seven different missile and projectile configurations with widely varying fin shapes and sizes were tested, and their measured data are tabulated. The present correlation is very simple, and can be used to refine initial configuration selection and thus reduce the number of costly full-flowfield computations. The correlation is limited to missiles with only one set of fins and to small angles of attack. RP Mikhail, AG (reprint author), USA,RES LAB,DIV PROP & LIGHT,WEAPONS TECHNOL DIRECTORATE,ABERDEEN PROVING GROUND,MD 21005, USA. NR 14 TC 7 Z9 9 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0022-4650 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD NOV-DEC PY 1995 VL 32 IS 6 BP 929 EP 937 DI 10.2514/3.26711 PG 9 WC Engineering, Aerospace SC Engineering GA TK774 UT WOS:A1995TK77400001 ER PT J AU Mikhail, AG AF Mikhail, AG TI Flow simulation and drag anatomy for antitank projectile configurations SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Note ID MODES RP Mikhail, AG (reprint author), USA,BALLIST RES LAB,DIV PROP & FLIGHT,WEAPONS TECHNOL DIRECTORATE,ABERDEEN PROVING GROUND,MD 21005, USA. NR 13 TC 0 Z9 0 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0022-4650 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD NOV-DEC PY 1995 VL 32 IS 6 BP 1079 EP 1081 DI 10.2514/3.26735 PG 3 WC Engineering, Aerospace SC Engineering GA TK774 UT WOS:A1995TK77400026 ER PT J AU JENSEN, PS WATANABE, HK RICHTERS, JE CORTES, R ROPER, M LIU, S AF JENSEN, PS WATANABE, HK RICHTERS, JE CORTES, R ROPER, M LIU, S TI PREVALENCE OF MENTAL DISORDER IN MILITARY CHILDREN AND ADOLESCENTS - FINDINGS FROM A 2-STAGE COMMUNITY SURVEY SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY LA English DT Article DE DIAGNOSTIC INTERVIEW SCHEDULE FOR CHILDREN; CHILD BEHAVIOR CHECKLIST; MILITARY CHILDREN; MILITARY FAMILIES; PREVALENCE; MENTAL DISORDER; PSYCHOPATHOLOGY ID FAMILY SYNDROME; POPULATION; RISK AB Objective: Because previous reports have suggested that children of military families are at greater risk for psychopathology, this study examines the levels of psychopathology in an epidemiological community sample of military children all living on a military post. Method: Standardized psychopathology rating scales and a structured diagnostic interview (the Diagnostic interview Schedule for Children [DISC], version 2.1) were used in a multimethod, multistage survey; 294 six- to seventeen-year-old military children and their parents participated in the study. Results: Parent- and child-administered structured DSM-III-R DISC interviews indicated that children's levels of psychopathology were at levels consistent with studies of other normal samples. In addition, parents' and children's symptom checklist ratings of children were at national norms, as were parents' ratings of their own symptoms. Conclusions: Overall results do not support the notion that levels of psychopathology are greatly increased in military children. Further studies of military families should address the effects of rank and socioeconomic status, housing, and the current impact of life stressors on the parents as well as the children, in order to avoid drawing erroneous conclusions about parts or all of the military community. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307. NIMH,DIV EPIDEMIOL & SERV RES,EPIDEMIOL & PSYCHOPATHOL RES BRANCH,ROCKVILLE,MD 20857. RP JENSEN, PS (reprint author), NIMH,DIV CLIN & TREATMENT RES,CHILD & ADOLESCENT DISORDERS RES BRANCH,ROOM 18C-17,ROCKVILLE,MD 20857, USA. OI Richters, John/0000-0002-6780-1828; Jensen, Peter/0000-0003-2387-0650 NR 23 TC 60 Z9 61 U1 2 U2 5 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0890-8567 J9 J AM ACAD CHILD PSY JI J. Am. Acad. Child Adolesc. Psychiatr. PD NOV PY 1995 VL 34 IS 11 BP 1514 EP 1524 DI 10.1097/00004583-199511000-00019 PG 11 WC Psychology, Developmental; Pediatrics; Psychiatry SC Psychology; Pediatrics; Psychiatry GA TB165 UT WOS:A1995TB16500019 PM 8543520 ER PT J AU WALSH, DS FARLEY, MF BEARD, JS SAU, P TESAR, J JAMES, WD AF WALSH, DS FARLEY, MF BEARD, JS SAU, P TESAR, J JAMES, WD TI SYSTEMIC LUPUS-ERYTHEMATOSUS - NEPHRITIS, DILATED CARDIOMYOPATHY, AND EXTENSIVE CUTANEOUS DEPIGMENTATION RESPONSIVE TO HYDROXYCHLOROQUINE SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Note ID DIASTOLIC FUNCTION; DISEASE C1 WALTER REED ARMY MED CTR,RHEUMATOL SERV,WASHINGTON,DC 20307. RP WALSH, DS (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 15 TC 5 Z9 5 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD NOV PY 1995 VL 33 IS 5 BP 828 EP 830 PN 1 PG 3 WC Dermatology SC Dermatology GA TD253 UT WOS:A1995TD25300022 PM 7593787 ER PT J AU CALDWELL, JB RYAN, MT BENSON, PM JAMES, WD AF CALDWELL, JB RYAN, MT BENSON, PM JAMES, WD TI CUTANEOUS ANGIOSARCOMA ARISING IN THE RADIATION SITE OF A CONGENITAL HEMANGIOMA SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Note ID SOFT-TISSUE; IRRADIATION; THERAPY; LYMPHANGIOSARCOMA; SKIN; HEMANGIOSARCOMA; CHILDHOOD; CARCINOMA; BREAST; FACE AB We describe a patient in whom angiosarcoma developed at the site of a hemangioma that was treated during infancy with radiation for refractory thrombocytopenia. Our findings, along with those of the 10 reported cases from the world literature, are summarized. One third of angiosarcomas arise in the skin. They most often show one of three clinical patterns. First and most common is occurrence as a bruiselike lesion on the scalp or face of an elderly person. Second in frequency is the Stewart-Treves syndrome. Third and least common is angiosarcoma developing as a sequela of previous radiation therapy. The prognosis in general is poor, with a mean survival length of 24 months and a 5-year survival rate of 10%. Effective treatment relies on early diagnosis and wide-margin surgical excision. C1 USN,MED CTR,DEPT PATHOL,PORTSMOUTH,HANTS,ENGLAND. RP CALDWELL, JB (reprint author), WALTER REED ARMY MED CTR,DEPT DERMATOL,WASHINGTON,DC 20307, USA. NR 49 TC 41 Z9 42 U1 0 U2 3 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD NOV PY 1995 VL 33 IS 5 BP 865 EP 870 PN 2 PG 6 WC Dermatology SC Dermatology GA TE577 UT WOS:A1995TE57700003 PM 7593798 ER PT J AU MONTEMARANO, AD SAU, P JAMES, WD AF MONTEMARANO, AD SAU, P JAMES, WD TI SUPERFICIAL PAPILLARY ADENOMATOSIS OF THE NIPPLE - A CASE-REPORT AND REVIEW OF THE LITERATURE SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Review ID EROSIVE ADENOMATOSIS AB Superficial papillary adenomatosis of the nipple is a benign tumor of the ductal epithelium that clinically resembles Paget's disease. Histologically, the tumor is characterized by proliferating ductal structures lined by a double layer of columnar epithelium. Keratin cysts and apical intraluminal projections are commonly found. Since this entity's original description as ''florid papillomatosis'' in 1954, 174 cases have been reported in the English language literature. We review these cases and report a classic example. RP MONTEMARANO, AD (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 23 TC 17 Z9 17 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD NOV PY 1995 VL 33 IS 5 BP 871 EP 875 DI 10.1016/0190-9622(95)90425-5 PN 2 PG 5 WC Dermatology SC Dermatology GA TE577 UT WOS:A1995TE57700004 PM 7593799 ER PT J AU HURSH, SR WINGER, G AF HURSH, SR WINGER, G TI NORMALIZED DEMAND FOR DRUGS AND OTHER REINFORCERS SO JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR LA English DT Article DE BEHAVIORAL ECONOMICS; NORMALIZED DEMAND; DEMAND CURVE; ELASTICITY; DRUG SELF-ADMINISTRATION; COST; UNIT PRICE; FIXED-RATIO SCHEDULE; OVERALL RESPONSE OUTPUT; COCAINE; ALFENTANIL; NALBUPHINE; METHOHEXITAL; PHENCYCLIDINE; RHESUS MONKEYS ID BEHAVIORAL ECONOMICS; RHESUS-MONKEYS; DEPENDENCE; FOOD AB The concepts of behavioral economics have proven to be useful for understanding the environmental control of overall levels of responding for a variety of commodities, including reinforcement by drug self-administration. These general concepts have implications for the assessment of abuse liability and drug abuse intervention and the formulation of public policy on drug abuse. An essential requirement is the ability to compare the demand for different drugs directly in order to assess relative abuse liability, and to compare demand for the same drug under different environmental and biological interventions to assess their ability to reduce demand. Until now, such comparisons were hampered by the confounding effect of varying drug doses and potencies that prevent quantitative comparisons of demand elasticity-sensitivity of consumption and responding to the constraint of price (effort). In this paper we describe a procedure to normalize demand-curve analysis that permits dose- and potency-independent comparisons of demand across drugs. The procedure is shown to be effective for comparing drug demand within and across the drug classes. The technique permits a quantitative ordering of demand that is consistent with the peak levels of responding maintained by the drugs. The same technique is generalized for the comparison of other types of reinforcers under different biological conditions. C1 WALTER REED ARMY INST RES,WASHINGTON,DC. UNIV MICHIGAN,ANN ARBOR,MI 48109. FU NIDA NIH HHS [DA 00254, DA 04403, DA 05951] NR 26 TC 126 Z9 126 U1 2 U2 4 PU SOC EXP ANALYSIS BEHAVIOR INC PI BLOOMINGTON PA INDIANA UNIV DEPT PSYCHOLOGY, BLOOMINGTON, IN 47405 SN 0022-5002 J9 J EXP ANAL BEHAV JI J. Exp. Anal. Behav. PD NOV PY 1995 VL 64 IS 3 BP 373 EP 384 DI 10.1901/jeab.1995.64-373 PG 12 WC Psychology, Biological; Behavioral Sciences; Psychology, Experimental SC Psychology; Behavioral Sciences GA TE747 UT WOS:A1995TE74700009 PM 8551194 ER PT J AU Watson, GP Berger, SD Liddle, JA Fetter, LA Farrow, RC Tarascon, RG Mkrtchyan, M Novembre, AE Blakey, MI Bolan, KJ Poli, L AF Watson, GP Berger, SD Liddle, JA Fetter, LA Farrow, RC Tarascon, RG Mkrtchyan, M Novembre, AE Blakey, MI Bolan, KJ Poli, L TI Precise measurement of the effective backscatter coefficient for 100-keV electron-beam lithography on Si SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article; Proceedings Paper CT 39th International Conference on Electron, Ion, and Photon Beam Technology and Nanofabrication (EIPBN) CY MAY 30-JUN 02, 1995 CL SCOTTSDALE, AZ SP Amer Vacuum Soc, IEEE, Electron Device Soc, Opt Soc Amer ID EXPOSURE AB A technique has been developed to measure the effective backscatter coefficient in resist that is more reliable than conventional techniques since (1) it does not require precise information about the form of the backscatter profile, and (2) it makes use of the complete resist exposure response function. The estimated backscatter coefficient on Si for 100 keV electrons has been found to be 0.38+/-0.05, significantly lower than other published values determined at this energy. Within the accuracy of the measurement, the backscatter coefficient is the same for tests determined by scattering with angular limitation projection electron lithography and direct write exposures. (C) 1995 American Vacuum Society. C1 USA,RES LAB,FT MONMOUTH,NJ 07703. RP Watson, GP (reprint author), AT&T BELL LABS,MURRAY HILL,NJ 07974, USA. RI Liddle, James/A-4867-2013 OI Liddle, James/0000-0002-2508-7910 NR 8 TC 8 Z9 8 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD NOV-DEC PY 1995 VL 13 IS 6 BP 2535 EP 2538 DI 10.1116/1.588388 PG 4 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA TN816 UT WOS:A1995TN81600073 ER PT J AU MICHAEL, NL CHANG, G DARCY, LA TSENG, CJ BIRX, DL SHEPPARD, HW AF MICHAEL, NL CHANG, G DARCY, LA TSENG, CJ BIRX, DL SHEPPARD, HW TI FUNCTIONAL-CHARACTERIZATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 NEF GENES IN PATIENTS WITH DIVERGENT RATES OF DISEASE PROGRESSION SO JOURNAL OF VIROLOGY LA English DT Article ID VPU-INDUCED DEGRADATION; SURFACE CD4 EXPRESSION; DOWN-REGULATION; NUCLEOTIDE-SEQUENCE; CYTOPLASMIC DOMAIN; TRANSGENIC MICE; MINIATURE SWINE; HIV-1 INFECTION; AIDS VIRUS; POLYMORPHISM AB We have studied the sequence and function of the human immunodeficiency virus type 1 (HIV-1) nef genes from nine patients with highly divergent rates of disease progression enrolled in a longitudinal study of HIV disease. Over an average of 7.8 years of follow up, three patients had net positive changes in CD4(+) T-cell counts, three patients had net negative changes in CD4(+) T cells but did not develop AIDS, and three patients progressed to AIDS. The nef gene from each of these patients was amplified and cloned, and the sequence of 8 to 10 clones was determined. Only 2 of 88 (2.3%) nef genes recovered from these nine patients were grossly defective. Moreover, there was no relationship between the phylogeny of nef sequences and the corresponding rates of disease progression from these patients. Representative nef genes from all nine patients were tested for their abilities to downregulate cell surface CD4 in a transient-transfection assay. There was no correlation found between the functions of the nef genes from these patients and their corresponding rates of disease progression. We conclude that the nef gene is not a common mediator of the rate of HIV disease progression in natural infection. C1 HENRY M JACKSON FDN,ROCKVILLE,MD 20850. CALIF DEPT HLTH SERV,BERKELEY,CA 94704. RP MICHAEL, NL (reprint author), WALTER REED ARMY INST RES,DIV RETROVIROL,13 TAFT CT,SUITE 200,ROCKVILLE,MD 20850, USA. FU NIAID NIH HHS [N01-AI-82515] NR 62 TC 66 Z9 66 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD NOV PY 1995 VL 69 IS 11 BP 6758 EP 6769 PG 12 WC Virology SC Virology GA RZ100 UT WOS:A1995RZ10000019 PM 7474087 ER PT J AU WILLIAMS, AN VAZQUEZ, JH CRULL, TWW AF WILLIAMS, AN VAZQUEZ, JH CRULL, TWW TI OBLIQUE-WAVE DIFFRACTION BY NONCOLLINEAR SEGMENTED OFFSHORE BREAKWATERS SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article ID PERIODIC ARRAY; ELASTIC-WAVES; TRANSMISSION; REFLECTION; SCATTERING; CRACKS; PLATES AB A theoretical solution is presented for oblique-wave diffraction by a segmented offshore breakwater system consisting of an infinite array of equally spaced vertical barriers oriented at an arbitrary angle to the line joining their centers. The solution is obtained by a Green's function approach. The geometrical periodicity of the breakwater system reduces the problem to that of a singular integral equation for the potential difference across a single breakwater element. Zero-order reflection and transmission coefficients are defined in terms of the amplitudes of the asymptotic (propagating) diffracted waves traveling in the opposite direction to or the same direction as the incident waves, respectively. Numerical values of these coefficients are presented for a range of angles of wave incidence and breakwater orientation, for various breakwater geometric configurations. For certain parameter combinations, significant wave reflection can be achieved using this type of breakwater system. C1 TEXAS A&M UNIV,DEPT MARITIME SYST ENGRG,GALVESTON,TX 77553. USA,CORPS ENGINEERS,GALVESTON,TX 77553. RP WILLIAMS, AN (reprint author), UNIV HOUSTON,DEPT CIVIL & ENVIRONM ENGN,HOUSTON,TX 77204, USA. NR 12 TC 7 Z9 7 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD NOV-DEC PY 1995 VL 121 IS 6 BP 326 EP 333 DI 10.1061/(ASCE)0733-950X(1995)121:6(326) PG 8 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA RZ782 UT WOS:A1995RZ78200007 ER PT J AU Kamtekar, SD Pande, R Ayyagari, MS Marx, KA Kaplan, DL Kumar, J Tripathy, SK AF Kamtekar, SD Pande, R Ayyagari, MS Marx, KA Kaplan, DL Kumar, J Tripathy, SK TI A chemiluminescence-based biosensor for metal ion detection SO MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC MATERIALS SENSORS AND SYSTEMS LA English DT Article; Proceedings Paper CT Symposium on Biomolecular and Biomimetic Materials, at the Fall 1994 Materials-Research-Society Meeting CY NOV 28-DEC 02, 1994 CL BOSTON, MA SP Mat Res Soc DE alkaline phosphatase; metal ion detection; chemiluminescence; fibre optics ID ZINC; CADMIUM AB Inhibition of the native metalloenzyme, alkaline phosphatase, in the presence of some metal ions, and the reactivation of its apoenzyme by Zn(II) ions is used to determine metal ion concentrations. Alkaline phosphatase-catalysed hydrolysis of a chemiluminescent substrate, chloro 3-(4-methoxy spiro [1,2-dioxetane-3-2'-tricyclo-[3.3.1.1]-phenyl phosphate, generates light. By measuring the chemiluminescence signal strength in the presence or absence of metal ions, this reaction can be used to detect and determine metal ion concentrations. The immobilization of alkaline phosphatase on different glass surfaces by covalent coupling using a bifunctional reagent, glutaraldehyde, was demonstrated. Using chemiluminescence measurements, Zn(II), Be(II) and Bi(III) were detected in trace levels. This technique forms the basis in the development of a metal ion-based fibre optic sensor. C1 UNIV LOWELL,DEPT CHEM,CTR ADV MAT,LOWELL,MA 01854. USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. UNIV LOWELL,DEPT CHEM,CTR INTELLIGENT BIOMAT,LOWELL,MA 01854. UNIV LOWELL,DEPT PHYS,CTR ADV MAT,LOWELL,MA 01854. NR 16 TC 20 Z9 20 U1 1 U2 2 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0928-4931 J9 MAT SCI ENG C-BIOMIM JI Mater. Sci. Eng. C-Biomimetic Mater. Sens. Syst. PD NOV PY 1995 VL 3 IS 2 BP 79 EP 83 DI 10.1016/0928-4931(95)00095-X PG 5 WC Materials Science, Multidisciplinary SC Materials Science GA TK797 UT WOS:A1995TK79700004 ER PT J AU Wilkerson, RC Gaffigan, TV Lima, JB AF Wilkerson, RC Gaffigan, TV Lima, JB TI Identification of species related to Anopheles (Nyssorhynchus) albitarsis by random amplified polymorphic DNA-polymerase chain reaction (Diptera: Culicidae) SO MEMORIAS DO INSTITUTO OSWALDO CRUZ LA English DT Article DE Anopheles (Nyssorhynchus) albitarsis; Anopheles (Nyssorhynchus) marajoara; Anopheles; (Nyssorhynchus) deaneaorum; RAPD PCR; identification ID ARBITRARY PRIMERS; POPULATIONS; COMPLEX; MARKERS; BRAZIL; PCR AB Species-specific Random Amplified Polymorphic DNA-Polymerase Chain Reaction (RAPD-PCR) markers were used to identify four species related to Anopheles (Nyssorhynchus) albitarsis Lynch-Arribalzaga from 12 sites in Brazil and 4 in Venezuela. In a previous study (Wilkerson et al. 1995), which included sites in Paraguay and Argentina, these four species were designated ''A'', ''B'', ''C'' and ''D''. it was hypothesized that species A is An. (Nys.) albitarsis, species B is undescribed, species C is An. (Nys.) marajoara Galvao and Damasceno and species D is An (Nys.) deaneorum Rosa-Freitas. Species D, previously characterized by RAPD-PCR from a small sample from northern Argentina and southern Brazil, is reported here from the type locality of An. (Nys.) deaneorum, Guajara-Mirim, State of Rondonia, Brazil. Species C and D,were found by RAPD-PCR to be sympatric at Costa Marques, State of Rondonia, Brazil. Species A and C have yet to be encountered at the same locality. The RAPD markers for species C were found to be conserved over 4, 620 km; from Iguape State of Sao Paulo, Brazil to Rio Socuavo, State of Zulia, Venezuela. RAPD-PCR was determined to be an effective means for the identification of unknown specimens within this species complex. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. USA,MED RES UNIT,INST BIOL EXERCITO,BR-20911270 RIO JANEIRO,BRAZIL. FU NIAID NIH HHS [AI-31034] NR 28 TC 43 Z9 44 U1 0 U2 1 PU MEM INST OSWALDO CRUZ PI RIO DE JANEIRO PA SECRETARY CAIXA POSTAL 926, 20001 RIO DE JANEIRO, RJ, BRAZIL SN 0074-0276 J9 MEM I OSWALDO CRUZ JI Mem. Inst. Oswaldo Cruz PD NOV-DEC PY 1995 VL 90 IS 6 BP 721 EP 732 PG 12 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA TM827 UT WOS:A1995TM82700013 PM 8731368 ER PT J AU Buysse, JM Hartman, AB Strockbine, N Venkatesan, M AF Buysse, JM Hartman, AB Strockbine, N Venkatesan, M TI Genetic polymorphism of the ipaH multicopy antigen gene in Shigella spps and enteroinvasive Escherichia coli SO MICROBIAL PATHOGENESIS LA English DT Article DE Shigella; enteroinvasive Escherichia coli; ipaH; invasion plasmid ID DYSENTERIAE TYPE-1; MOLECULAR CHARACTERIZATION; NUCLEOTIDE-SEQUENCE; FLEXNERI 2A; PLASMID; IDENTIFICATION; VIRULENCE; PROTEIN; INFECTIONS; AMPLIFICATION AB The ipaH loci comprise a multicopy antigen gene family unique to Shigella species and enteroinvasive Escherichia coli (EIEC). DNA probes derived from the Shigella flexneri serotype 5 ipaH(7.8) gene were used to compare the molecular arrangement of ipaH alleles in a variety of Shigella and EIEC strains. Multiple copies of ipaH-homologous sequences were detected in all invasion plasmids examined. Oligonucleotide probes covering discrete 24 bp segments of the ipaH(7.8) gene and sequences flanking the ipaH(4.5) (probe H25) and ipaH(2.5) (probe H24) loci were used to define the extent of homology among invasion plasmid copies of ipaH in S. flexneri serotypes 1, 2 and 5 and in S. sonnei. IpaH alleles carried by these invasion plasmids were not structurally equivalent and showed sequence divergence at their amino- and carboxy-terminal ends. The H25 probe was shown to correspond to an IS629 sequence genetically linked to the ipaH alleles, while the H24 probe defined a DNA sequence found only in Shigella invasion plasmids. Chromosomal DNA from invasion plasmid-cured S. flexneri and S. sonnei strains hybridized a core ipaH(7.8) gene segment, indicating that portions of the ipaH(7.8) structural gene were reiterated and contained within the shigellae chromosomes. Based on the specificity of the ipaH(7.8) core probe and the detection of ipaH sequences on the invasion plasmids and chromosomes of Shigella strains, three polymorphic groups within a collection of forty S. dysenteriae 1 isolates received by the United States Centers for Disease Control in 1988 were identified using this probe. These results suggest that ipaH restriction fragment length polymorphisms may be useful in genetic lineage and epidemiologic studies of virulent shigellae. (C) 1995 Academic Press Limited C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BACTERIAL IMMUNOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTER INFECT,WASHINGTON,DC 20307. CTR DIS CONTROL,ENTER DIS LAB SECT,ATLANTA,GA 30333. NR 46 TC 15 Z9 20 U1 0 U2 4 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0882-4010 J9 MICROB PATHOGENESIS JI Microb. Pathog. PD NOV PY 1995 VL 19 IS 5 BP 335 EP 349 PG 15 WC Immunology; Microbiology SC Immunology; Microbiology GA TK665 UT WOS:A1995TK66500005 PM 8778567 ER PT J AU DANIEL, JN POLLY, DW VANDAM, BE AF DANIEL, JN POLLY, DW VANDAM, BE TI A STUDY OF THE EFFICACY OF NONOPERATIVE TREATMENT OF PRESUMED TRAUMATIC SPONDYLOLYSIS IN A YOUNG PATIENT POPULATION SO MILITARY MEDICINE LA English DT Article AB The purpose of this study is to report the results of nonoperative treatment of presumed traumatic spondylolysis in a young patient population seen at the Waiter Reed Army Medical Center Orthopaedic Surgery Spine Service from 1986 to 1994, A retrospective chart review analysis with recent follow-up was performed on 29 patients diagnosed through clinical examination and plain radiographs, Bone scan was reserved for those patients with an examination consistent with spondylolysis yet inconclusive plain films, All patients were treated with activity modification (to include a temporary profile for active duty military), full-time bracing (most commonly a thoraco-lumbosacral orthosis), and nonsteroidal anti-inflammatory drugs, Narcotic analgesics were added to this regimen, if indicated, There were 23 males and 6 females with an average age of 21 (range 13-31), There were 7 United States Military Academy cadets, 7 dependent children, 5 noncommissioned officers, 6 enlisted, and 4 officers, Of the 29 patients with spondylolysis, 20 had an L5 defect, 6 had an L4 defect, 4 had an L3 defect, and 1 had an L2 defect, Two of the 29 patients healed their spondylolysis, but the remainder failed nonoperative treatment. In the population of patients referred to our institution, spondylolysis is not a benign process, The literature suggests that the majority of these injuries heal, yet this has not been our experience, We propose that if the patient is diagnosed acutely with a fracture of the pars interarticularis and the aforementioned proven regimen is initiated, the chances for a successful nonoperative outcome are optimized, A delay in diagnosis and therefore treatment may compromise nonoperative treatment and necessitate operative intervention in an attempt to restore the patient to the preinjury level of activity. RP DANIEL, JN (reprint author), WALTER REED ARMY MED CTR,ORTHOPED SURG SPINE SERV,WASHINGTON,DC 20307, USA. NR 0 TC 11 Z9 11 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 1995 VL 160 IS 11 BP 553 EP 555 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA TE046 UT WOS:A1995TE04600004 PM 8538888 ER PT J AU WILLIFORD, SL JOHNSON, DF AF WILLIFORD, SL JOHNSON, DF TI IMPACT OF PHARMACIST COUNSELING ON MEDICATION KNOWLEDGE AND COMPLIANCE SO MILITARY MEDICINE LA English DT Article AB The impact of discharge counseling was measured in a veteran patient population in a large tertiary-care government medical center. Upon discharge, seventy patients were randomly assigned to one of two groups: one group received verbal medication counseling from a pharmacist, the other group did not, Medication knowledge and compliance were assessed by interviewing each patient approximately 6 weeks after discharge, Sixty patients (31 counseled, 29 uncounseled) completed the study, Forty-five patients were from our rehabilitation division (housing psychiatric, intermediate, and long-term care patients), and 15 patients were from our acute-care division, Overall, counseled patients were no more knowledgeable or compliant than uncounseled patients. However, among those patients discharged from our acute-care division, counseled patients were more knowledgeable and compliant than uncounseled patients, In all patients, medication knowledge and compliance decreased as their number of medications increased, Our discharge counseling program had little impact when examining all study patients. But in acute-care patients, discharge counseling did increase both medication knowledge and compliance, Our study also showed that, in both counseled and uncounseled patients, medication knowledge and compliance decreased as the number of discharge medications increased, and additional pharmacist counseling would likely prove beneficial to those patients discharged on multiple medications. RP WILLIFORD, SL (reprint author), WOMACK ARMY MED CTR,FT BRAGG,NC 28307, USA. NR 0 TC 27 Z9 27 U1 0 U2 2 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 1995 VL 160 IS 11 BP 561 EP 564 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA TE046 UT WOS:A1995TE04600007 PM 8538891 ER PT J AU HALL, DP JANSEN, JA AF HALL, DP JANSEN, JA TI STRESS AND AROUSAL IN DEPLOYMENT OF A COMBAT SUPPORT HOSPITAL SO MILITARY MEDICINE LA English DT Article AB Two hundred thirty-nine soldiers from the 28th Combat Support Hospital were evaluated for stress and arousal during deployment preparations for Operation Uphold Democracy. We measured stress and arousal using the Stress Arousal Checklist and found increased levels of arousal in officers and older soldiers, We also found higher levels of arousal in soldiers reporting a greater number of hours of sleep during the preceding 24 hours, We found no significant difference in stress scores for several demographic and coping behavior groups, Based on lower arousal scores, younger, sleep-deprived, and enlisted soldiers may be at the highest risk for accidents during deployment preparations. RP HALL, DP (reprint author), 28TH COMBAT SUPPORT HOSP,MED DETACHMENT 528,FT BRAGG,NC 28307, USA. NR 0 TC 2 Z9 2 U1 1 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 1995 VL 160 IS 11 BP 581 EP 583 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA TE046 UT WOS:A1995TE04600012 PM 8538896 ER PT J AU DEMEO, CM ZANNELLI, ME JOYCE, AP ISHIHARA, S BEAUSANG, LA AF DEMEO, CM ZANNELLI, ME JOYCE, AP ISHIHARA, S BEAUSANG, LA TI DEVELOPMENT OF A SENSITIVE 2-SITE IMMUNOMETRIC ELISA FOR THE MEASUREMENT OF PIG TNF-ALPHA SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract C1 ENDOGEN INC,CAMBRIDGE,MA 02139. USA,INST SURG RES,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOL PI BETHESDA PA PUBL OFFICE 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PD NOV PY 1995 VL 6 SU S BP 97 EP 97 PG 1 WC Cell Biology SC Cell Biology GA TF513 UT WOS:A1995TF51300098 ER PT J AU DUFFY, PE OCKENHOUSE, CF AF DUFFY, PE OCKENHOUSE, CF TI SEQUESTRIN IS A HIGH-AFFINITY COUNTER-RECEPTOR EXPRESSED BY PLASMODIUM-FALCIPARUM WHICH SPECIFICALLY BINDS THE OKM8 EPITOPE OF CD36 SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOL PI BETHESDA PA PUBL OFFICE 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PD NOV PY 1995 VL 6 SU S BP 1019 EP 1019 PG 1 WC Cell Biology SC Cell Biology GA TF513 UT WOS:A1995TF51301019 ER PT J AU CROSS, A ROTHWELL, S HAMMACK, C DECOSTER, M AF CROSS, A ROTHWELL, S HAMMACK, C DECOSTER, M TI PRIMING OF NEUTROPHIL SUPEROXIDE RESPONSE BY ENDOTOXIN REQUIRES CONTINUOUS RECEPTOR OCCUPANCY SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOL PI BETHESDA PA PUBL OFFICE 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PD NOV PY 1995 VL 6 SU S BP 1294 EP 1294 PG 1 WC Cell Biology SC Cell Biology GA TF513 UT WOS:A1995TF51301293 ER PT J AU KRAKAUER, T AF KRAKAUER, T TI IL-10 INHIBITS THE ADHESION OF LEUKOCYTIC CELLS TO IL-1-ACTIVATED HUMAN ENDOTHELIAL-CELLS SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,DIV TOXICOL,FREDERICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOL PI BETHESDA PA PUBL OFFICE 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PD NOV PY 1995 VL 6 SU S BP 1311 EP 1311 PG 1 WC Cell Biology SC Cell Biology GA TF513 UT WOS:A1995TF51301313 ER PT J AU PURI, AK GEMSKI, P JETT, M AF PURI, AK GEMSKI, P JETT, M TI INHIBITION OF STAPHYLOCOCCAL-ENTEROTOXIN-B (SEB) BIOLOGICAL-ACTIVITY BY BLOCKING THE 5-LIPOXYGENASE PATHWAY SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOL PI BETHESDA PA PUBL OFFICE 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PD NOV PY 1995 VL 6 SU S BP 1388 EP 1388 PG 1 WC Cell Biology SC Cell Biology GA TF513 UT WOS:A1995TF51301385 ER PT J AU HINES, JF GHIM, SJ SCHLEGEL, R JENSON, AB AF HINES, JF GHIM, SJ SCHLEGEL, R JENSON, AB TI PROSPECTS FOR A VACCINE AGAINST HUMAN PAPILLOMAVIRUS SO OBSTETRICS AND GYNECOLOGY LA English DT Review ID CERVICAL INTRAEPITHELIAL NEOPLASIA; NATURAL-HISTORY; INFECTION; VIRUS; TYPE-16; EXPRESSION; PREVALENCE; CELLS; WOMEN; DNA AB Objective: To summarize existing data regarding the feasibility of developing strategies for prophylactic and therapeutic vaccination against human papillomavirus (HPV) infection. Data Sources: We used the Medline data base and reference lists of articles to identify English-language papers that evaluate strategies for prophylactic and therapeutic vaccination against HPV infection. Methods of Study Selection: Our search uncovered several reports of systems that produce recombinant HPV major capsid proteins as antigens for biochemical, molecular, and immunologic studies and investigations that evaluate cell-mediated immune responses to HPV-induced, tumor-associated peptides. Data Extraction and Synthesis: Recombinant HPV major capsid proteins, which self-assemble into virus-like particles, are produced in quantity, mimic the conformation of native virions, react with neutralizing antibodies, and are type-specific. Human papillomavirus early viral peptides induce cytotoxic T lymphocyte responses that retard tumor progression and protect against tumor development after challenge in animal models. Conclusions: Recombinant papillomavirus virus-like particles are highly antigenic, protective in animal models, lack potentially carcinogenic viral DNA, and are, therefore, ideal candidates for a prophylactic vaccine against HPV infection. Immunization with HPV tumor peptides may be beneficial in tumor prevention, regression, and rejection. Vaccines against HPV infection can be important in reducing the incidence of cervical dysplasia and carcinoma worldwide, particularly in developing countries. C1 GEORGETOWN UNIV,MED CTR,DEPT PATHOL,WASHINGTON,DC 20007. RP HINES, JF (reprint author), BROOKE ARMY MED CTR,DEPT OBSTET & GYNECOL,GYNECOL ONCOL SEV,FT SAM HOUSTON,SAN ANTONIO,TX 78234, USA. NR 30 TC 14 Z9 14 U1 0 U2 0 PU ELSEVIER SCIENCE PUBL CO INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD NOV PY 1995 VL 86 IS 5 BP 860 EP 866 DI 10.1016/0029-7844(95)00248-P PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA TB360 UT WOS:A1995TB36000033 PM 7566866 ER PT J AU YU, FTS LU, MZ LU, GW YIN, SH HUDSON, TD MCMILLEN, DK AF YU, FTS LU, MZ LU, GW YIN, SH HUDSON, TD MCMILLEN, DK TI OPTIMUM TARGET DETECTION USING A SPATIAL-DOMAIN BIPOLAR COMPOSITE FILTER WITH A JOINT TRANSFORM CORRELATOR SO OPTICAL ENGINEERING LA English DT Article DE PATTERN RECOGNITION; ROTATION INVARIANCE; BIPOLAR COMPOSITE FILTER; SIMULATED ANNEALING ALGORITHM ID LIQUID-CRYSTAL TELEVISION; SIMULATED ANNEALING ALGORITHM; PATTERN-RECOGNITION; BINARY PHASE AB Synthesis of a spatial-domain bipolar composite filter (SBCF) using simulated annealing algorithm is presented. Since a SBCF is a spatial-domain filter, it is very suitable for implementation in a joint transform correlator. To alleviate the stringent control requirement of a phase-modulated spatial light modulator (SLM), a position-encoding technique is used to generate the SBCF as well as the input objects. Experimental demonstrations are also provided, in which it is shown that the SBCF has a higher discrimination capability of extracting the target objects against the antitarget objects. C1 USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898. RP YU, FTS (reprint author), PENN STATE UNIV,DEPT ELECT ENGN,UNIVERSITY PK,PA 16802, USA. NR 24 TC 10 Z9 10 U1 0 U2 2 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD NOV PY 1995 VL 34 IS 11 BP 3200 EP 3207 DI 10.1117/12.213582 PG 8 WC Optics SC Optics GA TF307 UT WOS:A1995TF30700016 ER PT J AU VORONTSOV, MA RICKLIN, JC CARHART, GW AF VORONTSOV, MA RICKLIN, JC CARHART, GW TI OPTICAL-SIMULATION OF PHASE-DISTORTED IMAGING-SYSTEMS - NONLINEAR AND ADAPTIVE OPTICS APPROACH SO OPTICAL ENGINEERING LA English DT Article DE OPTICAL REMOTE SENSING; IMAGE PROCESSING; NONLINEAR OPTICS; ADAPTIVE OPTICS; PHASE-DISTORTED IMAGING SYSTEMS AB We discuss a technique based on nonlinear and adaptive optics for simulation of phase-distortion effects in imaging systems. This technique uses a nonlinear two-dimensional optical feedback system to produce a controllable spatially and temporally varying chaotic intensity distribution. The intensity pattern is converted into a spatially varying thin phase screen using an optically addressed spatial phase modulator. A chaotic phase distortion is then introduced into an imaging system's output image by propagation through the phase screen. A deformable mirror with computer control is used for simulation of large-scale phase distortions. C1 USA,RES LAB,BATTLEFIELD ENVIRONM DIRECTORATE,WHITE SANDS MISSILE RANGE,NM 88002. MOSCOW MV LOMONOSOV STATE UNIV,CTR INT LASER,MOSCOW 119899,RUSSIA. RP VORONTSOV, MA (reprint author), NEW MEXICO STATE UNIV,DEPT MECH ENGN,LAS CRUCES,NM 88003, USA. NR 29 TC 30 Z9 30 U1 0 U2 1 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD NOV PY 1995 VL 34 IS 11 BP 3229 EP 3238 DI 10.1117/12.213607 PG 10 WC Optics SC Optics GA TF307 UT WOS:A1995TF30700020 ER PT J AU Rollins, NK Wen, TS Dominguez, R AF Rollins, NK Wen, TS Dominguez, R TI Crossed cerebellar atrophy in children: A neurologic sequela of extreme prematurity SO PEDIATRIC RADIOLOGY LA English DT Article ID TEMPORARY BALLOON OCCLUSION; DIASCHISIS; METABOLISM; INFARCTION AB Unilateral atrophy of a cerebellar hemisphere occurring as a sequela of ischemic or destructive injury of the contralateral cerebral hemisphere is uncommon in children. We reviewed our experience with this phenomenon and found an unexpected association with extreme prematurity and a complicated perinatal course with a poor subsequent neurologic outcome. We retrospectively identified eight children, aged 8 months to 13 years, in whom cerebellar atrophy associated with cerebral injury was diagnosed on MR or CT, and reviewed their past medical history neurologic findings, and neuroimaging studies. Seven patients were born extremely premature, EGA 25-28 weeks, and had severe perinatal intracranial hemorrhage. Neurologic problems include severe developmental delay in seven, spastic paresis in six, and seizures in five. Neuroimaging showed severe unilateral holohemispheric atrophy in four, bilateral asymmetric holohemispheric atrophy in two, and left temporoparietal atrophy in one. Cerebellar atrophy was unilateral in five and bilateral but asymmetric in two. Gliosis of the atrophic cerebellum occurred in one patient. Sequential neuroimaging in one patient showed evolution of crossed cerebellar atrophy at 8 months of age. The final patient, a term infant, had an idiopathic perinatal left cerebral infarct. In our experience, crossed cerebellar atrophy was an uncommon manifestation of extreme prematurity complicated by severe intracranial hemorrhage and/or ischemic necrosis of white matter. The cerebellar atrophy is most often a secondary degenerative phenomenon rather than a result of direct cerebellar injury. C1 UNIV TEXAS,SW MED CTR,DALLAS,TX 75235. MED CTR PLANO,DEPT RADIOL,PLANO,TX 75235. BROOKE ARMY MED CTR,DEPT RADIOL,FT SAM HOUSTON,TX 78234. RP Rollins, NK (reprint author), CHILDRENS MED CTR,DEPT RADIOL,1935 MOTOR ST,DALLAS,TX 75235, USA. NR 14 TC 27 Z9 28 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0301-0449 J9 PEDIATR RADIOL JI Pediatr. Radiol. PD NOV PY 1995 VL 25 SU 1 BP S20 EP S25 PG 6 WC Pediatrics; Radiology, Nuclear Medicine & Medical Imaging SC Pediatrics; Radiology, Nuclear Medicine & Medical Imaging GA TM948 UT WOS:A1995TM94800005 PM 8577528 ER PT J AU DOWLING, JP GEABANACLOCHE, J AF DOWLING, JP GEABANACLOCHE, J TI SCHRODINGER MODAL STRUCTURE OF CUBICAL, PYRAMIDAL, AND CONICAL, EVANESCENT LIGHT-WAVE GRAVITATIONAL ATOM TRAPS SO PHYSICAL REVIEW A LA English DT Article ID DEBROGLIE WAVES; MIRROR; REFLECTION; INTERFEROMETER; HYDROGEN; CAVITY AB We investigate the modal structure of Schrodinger's equation in several evanescent light-wave gravitational traps. Three configurations are proposed that optically confine an atom inside an atom-mirror cavity: a cubical, a pyramidal, and a conical gravitational trap. C1 UNIV ARKANSAS,DEPT PHYS,FAYETTEVILLE,AR 72701. RP DOWLING, JP (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,WEAPONS SCI DIRECTORATE,AMSMI RD WS ST,REDSTONE ARSENAL,AL 35898, USA. RI Gea-Banacloche, Julio/J-7546-2013; DOWLING, JONATHAN/L-2749-2013 OI Gea-Banacloche, Julio/0000-0001-9482-9060; NR 40 TC 15 Z9 15 U1 0 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD NOV PY 1995 VL 52 IS 5 BP 3997 EP 4003 DI 10.1103/PhysRevA.52.3997 PG 7 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA TE173 UT WOS:A1995TE17300085 ER PT J AU SWARTZ, JC GUENTHER, BD DELUCIA, FC GUO, W JONES, CR KOSAI, H DUTTA, JM AF SWARTZ, JC GUENTHER, BD DELUCIA, FC GUO, W JONES, CR KOSAI, H DUTTA, JM TI NONDESTRUCTIVE DIAGNOSTICS FOR RELATIVISTIC PICOSECOND BUNCHED ELECTRON-BEAMS SO PHYSICAL REVIEW E LA English DT Article ID POSITION AB The duration and form of relativistic picosecond electron bunches in the Duke University Mark III free-electron laser have been nondestructively measured by monitoring the submillimeter radiation produced by the bunches as they pass by or through a rectangular waveguide. Unlike other methods, our technique produces negligible electron bunch perturbation and allows real-time beam diagnostics to be performed simultaneously with free-electron laser (FEL) operation. We have measured 2.1-ps full width at half maximum duration electron bunches, studied the effect of electron gun and FEL modifications on bunch duration, and observed electron bunch variations during bunch trains. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. OHIO STATE UNIV,DEPT PHYS,COLUMBUS,OH 43210. N CAROLINA CENT UNIV,DEPT PHYS,DURHAM,NC 27707. RP SWARTZ, JC (reprint author), DUKE UNIV,DEPT PHYS,DURHAM,NC 27708, USA. NR 34 TC 5 Z9 5 U1 0 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1063-651X J9 PHYS REV E JI Phys. Rev. E PD NOV PY 1995 VL 52 IS 5 BP 5416 EP 5424 DI 10.1103/PhysRevE.52.5416 PN B PG 9 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA TG337 UT WOS:A1995TG33700038 ER PT J AU LASA, C HOLLINGER, J DROHAN, W MACPHEE, M AF LASA, C HOLLINGER, J DROHAN, W MACPHEE, M TI DELIVERY OF DEMINERALIZED BONE POWDER BY FIBRIN SEALANT SO PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Article ID INDUCTIVE PROTEIN; AFFINITY-CHROMATOGRAPHY; APATITE WOLLASTONITE; INDUCED OSTEOGENESIS; GROWTH-FACTORS; BOVINE BONE; BETA FAMILY; IMPLANTS; DEFECTS; MATRIX AB The main purpose of this study was to determine whether the use of fibrin sealant as a delivery vehicle for demineralized bone powder would result in bone induction in heterotopic and orthotopic sites. Rat demineralized bone powder alone or in different concentrations of fibrin sealant matrix (4, 8, 15, and 45 mg/ml) was bioassayed for bone induction by implantation in intramuscular sites. Distribution of treatment groups was as follows: demineralized bone powder alone (n = 12), demineralized bone powder plus 4 mg/ml fibrin sealant (n = 11), demineralized bone powder plus 8 mg/ml fibrin sealant (n = 11), demineralized bone powder plus 15 mg/ml fibrin sealant (n = 11), demineralized bone powder plus 45 mg/ml fibrin sealant (n = 10), 4 mg/ml fibrin sealant (n = 13), and 45 mg/ml fibrin sealant (n = 11). In a second group of rats, 8-mm critical-sized calvarial defects were created and treated with demineralized bone powder plus 30 mg/ml fibrin sealant. Intramuscular implants were retrieved after 28 days, while calvarial implants were retrieved at 28 days (n = 8), 3 months (n = 8),or 4 months (n = 5). Implants were then x-rayed and submitted for histology. Results showed bone formation as evidenced by radiopacity and histology. Radiopacity measurements of demineralized bone powder implants alone or in a fibrin sealant matrix were associated with immature woven bone at the implantation site. Fibrin sealant allowed bone formation by demineralized bone powder to occur, improved the handling of demineralized bone powder, and facilitated the shaping of implants. C1 USA,WALTER REED ARMY MED CTR,INST DENT RES,ROCKVILLE,MD. RP LASA, C (reprint author), AMER RED CROSS,HOLLAND LAB,15601 CRABBS BRANCH WAY,ROCKVILLE,MD 20855, USA. NR 46 TC 32 Z9 33 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0032-1052 J9 PLAST RECONSTR SURG JI Plast. Reconstr. Surg. PD NOV PY 1995 VL 96 IS 6 BP 1409 EP 1417 DI 10.1097/00006534-199511000-00027 PG 9 WC Surgery SC Surgery GA TC736 UT WOS:A1995TC73600027 PM 7480241 ER PT J AU LABBATE, LA FAVA, M OLESHANSKY, M ZOLTEC, J LITTMAN, A HARIG, P AF LABBATE, LA FAVA, M OLESHANSKY, M ZOLTEC, J LITTMAN, A HARIG, P TI PHYSICAL-FITNESS AND PERCEIVED STRESS - RELATIONSHIPS WITH CORONARY-ARTERY DISEASE RISK-FACTORS SO PSYCHOSOMATICS LA English DT Article ID ISCHEMIC HEART-DISEASE; PSYCHOLOGICAL STRESS; FOLLOW-UP; AMERICAN; MEN; MORTALITY; REDUCTION; OFFICERS AB This study evaluated the relationship between two biochemical risk factors for coronary artery disease, serum lipids and dehydroepiandrosterone-sulfate (DHEA-S), and both fitness and perceived stress among a cohort of senior male Army officers (N = 331). The participants under went a number of assessments gauging their fitness [exercise tolerance as measured by maximum ventilatory oxygen uptake (MVO(2))], psychological well-being, and biochemical cardiovascular risk factors. Perceived stress was significantly and inversely related to DHEA-S levels, even after. adjusting for age, though no relationship was found between perceived stress and serum lipids. Significant correlations were found between MVO(2) and high-density lipoprotein cholesterol and inversely between MVO(2) and triglycerides. Overall, the study's findings are generally consistent with the view that psychological stress and physical activity have opposite effects on parameters that affect cardiovascular status. C1 MASSACHUSETTS GEN HOSP,CLIN PSYCHOPHARMACOL UNIT,BOSTON,MA 02114. USA,OFF SURGEON GEN,FALLS CHURCH,VA. MASSACHUSETTS GEN HOSP,DEPT PSYCHIAT,BOSTON,MA 02114. USA,COLL WAR,CARLISLE,PA. RP LABBATE, LA (reprint author), WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20307, USA. NR 17 TC 24 Z9 24 U1 0 U2 1 PU AMER PSYCHIATRIC ASSOCIATION PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 SN 0033-3182 J9 PSYCHOSOMATICS JI Psychosomatics PD NOV-DEC PY 1995 VL 36 IS 6 BP 555 EP 560 PG 6 WC Psychiatry; Psychology SC Psychiatry; Psychology GA TC559 UT WOS:A1995TC55900006 PM 7501786 ER PT J AU ARONS, EM COLBECK, SC AF ARONS, EM COLBECK, SC TI GEOMETRY OF HEAT AND MASS-TRANSFER IN DRY SNOW - A REVIEW OF THEORY AND EXPERIMENT SO REVIEWS OF GEOPHYSICS LA English DT Review ID WEAK TEMPERATURE-GRADIENTS; FLUID PERMEABILITY; POROUS-MEDIA; RESERVOIR PHYSICS; ICE; CONDUCTIVITY; METAMORPHISM; POROSITY; BOUNDS; MODEL AB Porous materials are common on the Earth's surface and in the crust. Accordingly, their physical properties have received a lot of attention. A century ago, Maxwell and Rayleigh each modeled the physical properties of aggregate materials as discrete spheres embedded in continuous matrices. Although the particles of interest in snow are not spheres and do have interconnections, these basic models give first-order predictions of the thermal conductivity. In the last 3 decades, scientists have attempted to make the predictions more precise by determining the effect of geometry on heat and mass flow using basic physical models and data collected from images of planar sections of aggregates. Under favorable circumstances, physical parameters and quantitative microscopic parameters of an aggregate may be highly correlated, but physical understandings of the geometric effects are not likely to arise from such studies until physical models can be based on measurable fundamental parameters. In snow, as in other aggregates, that goal seems to be a long way from realization. RP ARONS, EM (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 141 TC 72 Z9 72 U1 0 U2 11 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 8755-1209 J9 REV GEOPHYS JI Rev. Geophys. PD NOV PY 1995 VL 33 IS 4 BP 463 EP 493 DI 10.1029/95RG02073 PG 31 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA TF756 UT WOS:A1995TF75600003 ER PT J AU XUE, SK ISKANDAR, IK SELIM, HM AF XUE, SK ISKANDAR, IK SELIM, HM TI ADSORPTION-DESORPTION OF 2,4,6-TRINITROTOLUENE AND HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE IN SOILS SO SOIL SCIENCE LA English DT Article AB We studied the adsorption-desorption behavior of TNT (2, 4, 6-trinitrotoluene) and RDX (hexahydro-1, 3, 5-trinitro-1, 3, 5-triazine) in a bentonite/sand reference material (Swy-1 montmorillonite clay mixed with acid-washed sand) and two selected soils (Norwood and Kolin). Release of TNT, RDX, and other compounds from a contaminated soil obtained from the Louisiana Army Ammunition Plant (AAP) site was also investigated. The kinetics of TNT and RDX retention were measured using batch methods for a range of input concentrations. For RDX, the adsorption isotherms were distinctly linear. The TNT adsorption isotherm for bentonite/sand mixture appeared linear and was described equally well using linear, Freundlich, Langmuir, and a modified Langmuir model. For the Norwood and Kolin soils, TNT adsorption isotherms exhibited distinct nonlinearity and the Freundlich model provided the best fit. As indicated by the K-d values, TNT exhibited stronger retention or affinity to all soils and the bentonite/sand mixture than for RDX. The RDX retention data indicated little time-dependent behavior. The TNT retention data indicated a continued decrease in TNT concentration with time in the Norwood and Kolin soils. This was possibly caused by the formation and subsequent adsorption of transformation products because transformation products, such as amino nitro toluene compounds, were identified during batch experiments. For the bentonite/sand mixture, TNT retention was rapid initially and reached apparent equilibrium within 1 day Unlike Kolin and Norwood soils, there was no hysteretic behavior of TNT adsorption-desorption by the bentonite/sand mixture and a mass balance suggested fully reversible retention mechanisms. C1 USA,COLD REG RES & ENGN LAB,DIV GEOCHEM,HANOVER,NH 03755. RP XUE, SK (reprint author), LOUISIANA STATE UNIV,STURGIS HALL,BATON ROUGE,LA 70803, USA. NR 15 TC 43 Z9 44 U1 0 U2 5 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0038-075X J9 SOIL SCI JI Soil Sci. PD NOV PY 1995 VL 160 IS 5 BP 317 EP 327 DI 10.1097/00010694-199511000-00001 PG 11 WC Soil Science SC Agriculture GA TE446 UT WOS:A1995TE44600001 ER PT J AU SELIM, HM XUE, SK ISKANDAR, IK AF SELIM, HM XUE, SK ISKANDAR, IK TI TRANSPORT OF 2,4,6-TRINITROTOLUENE AND HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE IN SOILS SO SOIL SCIENCE LA English DT Article ID LIQUID AB We investigated the fate and transport of explosives in soils. Transport experiments were conducted to describe the mobility of 2, 4, 6-trinitrotoluene (TNT) and hexahydro-1, 3, 5-trinitro-1, 3, 5-triazine (RDX) in a SWy-1 reference clay (bentonite mixed with sand) and two selected soils (Norwood and Kolin). Miscible displacement experiments in packed soil columns under steady flow were used. For the bentonite/sand column, TNT was highly mobile and fully reversible when methanol was used as the background solution. In contrast, with 0.005 M Ca(NO3)(2) as the background solution, the TNT pulse was strongly retarded with as much as 50% of that applied remaining within the bentonite/sand, Norwood, or Kolin columns. Products of the transformation of TNT to 4-Am-DNT and other compound were identified in the effluent solution. A 7-day flow interruption during the TNT pulse application resulted in decreased TNT levels in the effluent solution. This decrease corresponded to a sudden increase in the 4-Am-DNT concentration in the effluent, with peak concentrations of 0.60 mg ml(-1). For RDX, only limited retention as observed in all columns. These findings are consistent with results from adsorption-desorption batch experiments. The TNT and RDX transport results were successfully described by a nonlinear multireaction and transport model (MRTM), which accounted for equilibrium and kinetic (reversible and irreversible) retention mechanisms. However, efforts to describe RDX transport were more successful than efforts to describe TNT when independently determined (batch) parameters were used. The mobility of TNT, RDX, and other compounds from a contaminated soil obtained from a Louisiana Army Ammunition Plant (AAP) site was also investigated. A gradual release and subsequent movement of various contaminants, including HMX, TNT, RDX, TNB, 2-Am-DNT, and 4-Am-DNT, was observed. The leaching patterns were consistent with results from uncontaminated Kolin soil columns and reflected the affinity of contaminants during leaching in the AAP soil. C1 USA,COLD REG RES & ENGN LAB,DIV GEOCHEM,HANOVER,NH 03755. RP SELIM, HM (reprint author), LOUISIANA STATE UNIV,STURGIS HALL,BATON ROUGE,LA 70803, USA. NR 18 TC 33 Z9 33 U1 0 U2 4 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0038-075X J9 SOIL SCI JI Soil Sci. PD NOV PY 1995 VL 160 IS 5 BP 328 EP 339 DI 10.1097/00010694-199511000-00002 PG 12 WC Soil Science SC Agriculture GA TE446 UT WOS:A1995TE44600002 ER PT J AU SHANDERA, KC THOMPSON, IM WONG, RW COSSI, AF AF SHANDERA, KC THOMPSON, IM WONG, RW COSSI, AF TI DELAYED DEVELOPMENT OF MID-ILEAL CONDUIT STENOSIS - THE IMPORTANCE OF LIFELONG UROLOGIC FOLLOW-UP SO SOUTHERN MEDICAL JOURNAL LA English DT Article ID STRICTURES; LOOP AB Mid-ileal conduit stenosis is an unusual yet morbid complication following ileal conduit urinary diversion. We report the cases of four patients who developed mid-ileal stenosis at an average interval of 19.5 years after urinary diversion, with the longest interval being 25 years. This series emphasizes the importance of life-long follow-up of patients who have had urinary-intestinal diversion, C1 BROOKE ARMY MED CTR,DEPT SURG,UROL SERV,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DEPT RADIOL,FT SAM HOUSTON,TX 78234. NR 5 TC 1 Z9 1 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD NOV PY 1995 VL 88 IS 11 BP 1118 EP 1120 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA TC642 UT WOS:A1995TC64200006 PM 7481981 ER PT J AU STAFFORD, RG HINES, HB AF STAFFORD, RG HINES, HB TI URINARY ELIMINATION OF SAXITOXIN AFTER INTRAVENOUS-INJECTION SO TOXICON LA English DT Article ID BOMBARDMENT MASS-SPECTROMETRY; PARALYTIC SHELLFISH POISONS; LIQUID-CHROMATOGRAPHY; PRECHROMATOGRAPHIC OXIDATION; CAPILLARY ELECTROPHORESIS; FLUORESCENCE DETECTION; MARINE TOXINS; PSP TOXINS; TRANSFORMATION AB Paralytic shellfish poisoning is a serious public health concern throughout the world. An analytical method with diagnostic potential was used to isolate and measure saxitoxin, the most potent and studied paralytic shellfish poisoning toxin, in the urine of rats injected i.v. with sublethal doses (2 mu g/kg) of saxitoxin. Urine was collected at intervals between 4 and 144 hr after injection. Saxitoxin was isolated from urine with an ion-exchange procedure, identified, and measured with a precolumn-oxidation-HPLC procedure coupled with fluorescence detection. The identity of oxidized saxitoxin was confirmed with electrospray ionization mass spectrometry. Four hours after injection, approximately 19% of the injected saxitoxin dose was excreted. By 24 hr, approximately 58% of the administered dose was excreted. Average total urinary excretion of administered saxitoxin was approximately 68% for the full study period. These results demonstrate that small quantities of unmetabolized saxitoxin can be detected in rat urine up to 144 hr after i.v. administration, and that the analytical method may have diagnostic potential for saxitoxin intoxication and paralytic shellfish poisoning. RP STAFFORD, RG (reprint author), USA,MED RES INST INFECT DIS,DIV TOXINOL,FREDERICK,MD 21702, USA. NR 29 TC 14 Z9 19 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD NOV PY 1995 VL 33 IS 11 BP 1501 EP 1510 DI 10.1016/0041-0101(95)00081-V PG 10 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA TG686 UT WOS:A1995TG68600011 PM 8744989 ER PT J AU CESPEDES, RD PERETSMAN, SJ THOMPSON, IM JACKSON, C AF CESPEDES, RD PERETSMAN, SJ THOMPSON, IM JACKSON, C TI PROTECTION OF THE GERMINAL EPITHELIUM IN THE RAT FROM THE CYTOTOXIC EFFECTS OF CHEMOTHERAPY BY A LUTEINIZING-HORMONE-RELEASING HORMONE AGONIST AND ANTIANDROGEN THERAPY SO UROLOGY LA English DT Article ID MOUSE TESTIS; SPERMATOGENESIS; PROCARBAZINE; FERTILITY; FLUTAMIDE; ANDROGEN; ANALOGS; DAMAGE; CELLS AB Objectives. The protection of spermatogenesis during chemotherapy using an antiandrogen and a luteinizing hormone-releasing hormone (LHRH) agonist was examined in the rat. Previous studies using LHRH agonists alone have been inconclusive, as both protective and deleterious effects on the germinal epithelium have been reported. Flutamide has not previously been used in this manner but theoretically should protect the germinal epithelium, since flutamide rapidly blocks testosterone at the cellular level and also minimizes the testosterone ''flare'' when LHRH agonist therapy is initiated. Methods. Mature Sprague-Dawley rats were pretreated with flutamide, sustained-release goserelin acetate (Zoladex), or a combination of flutamide and sustained-release goserelin acetate for 14 days before 4 weekly doses of procarbazine were initiated. The seminiferous tubules were evaluated histologically after a 90-day regeneration period using the stem cell assay test. Results. After treatment with procarbazine alone, only 43% of the seminiferous tubules were active; however, 80% were active if protected with flutamide, 91% if protected with sustained-release goserelin acetate, and 95% if protected with both flutamide and goserelin acetate. Conclusions. Flutamide, sustained-release goserelin acetate, and a combination of these agents were effective in protecting the germinal epithelium of the rat during chemotherapy. A combination of flutamide and goserelin acetate provided the best protection. This study demonstrates for the first time the protective effect of flutamide and flutamide with goserelin acetate on the germinal epithelium during chemotherapy. C1 WILFORD HALL USAF MED CTR,DEPT CLIN INVEST,SAN ANTONIO,TX 78236. BROOKE ARMY MED CTR,DEPT UROL,SAN ANTONIO,TX. RP CESPEDES, RD (reprint author), WILFORD HALL USAF MED CTR,DEPT UROL,SAN ANTONIO,TX 78236, USA. NR 18 TC 5 Z9 5 U1 0 U2 1 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD NOV PY 1995 VL 46 IS 5 BP 688 EP 691 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA TE466 UT WOS:A1995TE46600016 PM 7495122 ER PT J AU PAYNE, CE DESHON, GE KROLL, JD SUMFEST, J AF PAYNE, CE DESHON, GE KROLL, JD SUMFEST, J TI COLONIC DUPLICATION - AN UNUSUAL CAUSE OF ENTEROVESICAL FISTULA SO UROLOGY LA English DT Note AB Intestinal duplications are rare, occurring in 1 in 4000 births. Even rarer are tubular hindgut duplications, with less than 75 cases reported in the literature to date. We report an uncommon case of an enterovesical fistula caused by a duplication of the sigmoid colon. This is the first reported case of a tubular colonic duplication presenting as a colovesical fistula in an adult. We discuss the presentation and shortcomings in the diagnosis and treatment of enterovesical fistulas and colonic duplications. RP PAYNE, CE (reprint author), TRIPLER ARMY MED CTR,DEPT UROL,HONOLULU,HI 96859, USA. NR 10 TC 11 Z9 11 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD NOV PY 1995 VL 46 IS 5 BP 726 EP 728 DI 10.1016/S0090-4295(99)80311-2 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA TE466 UT WOS:A1995TE46600025 PM 7495131 ER PT J AU KOTLOFF, KL NATARO, JP LOSONSKY, GA WASSERMAN, SS HALE, TL TAYLOR, DN SADOFF, JC LEVINE, MM AF KOTLOFF, KL NATARO, JP LOSONSKY, GA WASSERMAN, SS HALE, TL TAYLOR, DN SADOFF, JC LEVINE, MM TI A MODIFIED SHIGELLA VOLUNTEER CHALLENGE MODEL IN WHICH THE INOCULUM IS ADMINISTERED WITH BICARBONATE BUFFER - CLINICAL-EXPERIENCE AND IMPLICATIONS FOR SHIGELLA INFECTIVITY SO VACCINE LA English DT Article DE SHIGELLA; BACILLARY DYSENTERY; VACCINES; VOLUNTEERS; INFECTIVITY ID ORAL LIVE VACCINE; VIBRIO-CHOLERAE; SONNEI VACCINE; FLEXNERI 2A; HUMANS; EFFICACY; MONKEYS; IMMUNOGENICITY; PATHOGENESIS; RESISTANCE AB In the absence of a definitive immunologic correlate of protection against shigellosis, promising Shigella vaccine candidates have been selected based on their ability to confer resistance against experimental challenge with wild-type Shigella in healthy adult volunteers. A limitation of this model has been the low and often variable attack rate of illness among controls, necessitating repeated inpatient studies to demonstrate,statistically significant results. In this study, the Shigella challenge model was modified by using bicarbonate buffer instead of skimmed milk as the delivery vehicle to enhance survival of the ingested challenge inoculum. To determine the ability of the modified model to detect protective efficacy, 11 veteran volunteers (previously challenged with S. flexneri 2a in bicarbonate buffer) and 12 immunologically naive control subjects were challenged with 1.4 x 10(3) c.f.u. S. flexneri 2a. Shigellosis occurred in 3 veterans and 11 control subjects (27 vs 92%, p = 0.003), yielding a protective efficacy of 70%. Dose response was evaluated in an additional seven naive subjects who were inoculated with a log lower (1.4 x 10(2) c.f.u.) S. flexneri 2a and had a significantly diminished attack rate of shigellosis (3/7 (43%) vs 11/12 (92%), p = 0.04). These findings indicate that the modified bicarbonate challenge model using an inoculum of 10(3) c.f.u. is a safe, repeatable, and valid method of selecting Shigella vaccines and other immunoprophylactic agents that are likely to confer protection against natural shigellosis. C1 UNIV MARYLAND,SCH MED,DEPT PEDIAT,DIV INFECT DIS & TROP PEDIAT,BALTIMORE,MD 21201. UNIV MARYLAND,SCH MED,CTR VACCINE DEV,BALTIMORE,MD 21201. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. RP KOTLOFF, KL (reprint author), UNIV MARYLAND,SCH MED,DEPT MED,DIV GEOG MED,BALTIMORE,MD 21201, USA. RI kotloff, karen/E-7768-2012 OI kotloff, karen/0000-0003-1808-6431 NR 24 TC 65 Z9 66 U1 0 U2 1 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA LINACRE HOUSE JORDAN HILL, OXFORD, OXON, ENGLAND OX2 8DP SN 0264-410X J9 VACCINE JI Vaccine PD NOV PY 1995 VL 13 IS 16 BP 1488 EP 1494 DI 10.1016/0264-410X(95)00102-7 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA TF205 UT WOS:A1995TF20500002 PM 8578831 ER PT J AU BERCHTOLD, SR VANDERLOOP, SL SUIDAN, MT MALONEY, SW AF BERCHTOLD, SR VANDERLOOP, SL SUIDAN, MT MALONEY, SW TI TREATMENT OF 2,4-DINITROTOLUENE USING A 2-STAGE SYSTEM - FLUIDIZED-BED ANAEROBIC GRANULAR ACTIVATED CARBON REACTORS AND AEROBIC ACTIVATED-SLUDGE REACTORS SO WATER ENVIRONMENT RESEARCH LA English DT Article DE 2,4-DINITROTOLUENE; 2,4-DIAMINOTOLUENE; ACTIVATED CARBON; AEROBIC TREATMENT; ANAEROBIC TREATMENT DEGRADATION; FIXED FILM; FLUIDIZED BED ID BIOTRANSFORMATION; IDENTIFICATION; ADSORPTION; CAPACITY; OXYGEN AB Continuous-flow anaerobic fluidized-bed granular activated carbon bioreactors were used to treat 2,4-dinitrotoluene (2,4-DNT), a compound used in primary propellant production. A synthetic wastewater solution containing 2,4-DNT, ethanol, mineral ether, and a carbonate buffer and another solution containing growth nutrients and vitamins were fed to each of the two bioreactors. The influent ethanol concentrations were varied to determine the effect of ethanol concentration on the extent of 2,4-DNT degradation. The anaerobic bioreactors, when operated under methanogenic conditions with a primary substrate, were able to transform the 2,4-DNT into 2-amino-4-nitrotoluene (2-A-4-NT), 4-amino-2-nitrotoluene (4-A-2-NT), 2,4-diaminotoluene (2,4-DAT), and trace amounts oftoluene. During stable operation, for the range of non-zero influent ethanol concentrations evaluated in this study, the majority of the products were identified as 2,4-DAT. Batch activated sludge reactors were used to examine the fate of 2,4-DAT under aerobic conditions. 2,4-DAT (16 mg/L) were mineralized within 9 hours, indicating that a two-stage system may be an effective 2,4-DNT treatment strategy. C1 UNIV CINCINNATI,DEPT CIVIL & ENVIRONM ENGN,CINCINNATI,OH 45221. USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61824. NR 16 TC 41 Z9 42 U1 0 U2 6 PU WATER ENVIRONMENT FEDERATION PI ALEXANDRIA PA 601 WYTHE ST, ALEXANDRIA, VA 22314-1994 SN 1061-4303 J9 WATER ENVIRON RES JI Water Environ. Res. PD NOV-DEC PY 1995 VL 67 IS 7 BP 1081 EP 1091 DI 10.2175/106143095X133338 PG 11 WC Engineering, Environmental; Environmental Sciences; Limnology; Water Resources SC Engineering; Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA TD565 UT WOS:A1995TD56500010 ER PT J AU Edwards, JSA Askew, EW King, N AF Edwards, JSA Askew, EW King, N TI Rations in cold arctic environments: Recent American military experiences SO WILDERNESS & ENVIRONMENTAL MEDICINE LA English DT Review DE cold; nutritional intake; energy expenditure; held rations ID HUMANS; EXERCISE; WATER; FOOD AB The provision of an adequate diet is important to the success of any military operation, even more so when the rigors of a cold environment are imposed. Drawing on recent US military experiences, this article looks at some of the nutritional criteria to be considered and at lessons learned from recent field studies. Research to date suggests that, in order to support additional energy expenditure and to provide an adequate diet, 4500 kcal (18.83 MJ) per man per day are required. It is difficult to be precise about the optimum ratios of protein, fat, and carbohydrate; recommendations are made from the literature rather than from experimental evidence. Protein and salt might need to be further restricted, particularly when water supplies are limited. Little convincing evidence is available to demonstrate an increased tolerance to cold resulting from intakes of vitamins and minerals over and above recommended levels. Approximately 3 liters of water per man per day must be considered as a working minimum. C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 78 TC 1 Z9 1 U1 3 U2 3 PU CHAPMAN HALL LTD PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8HN SN 1080-6032 J9 WILD ENVIRON MED JI Wildern. Environ. Med. PD NOV PY 1995 VL 6 IS 4 BP 407 EP 422 DI 10.1580/1080-6032(1995)006[0407:RICAER]2.3.CO;2 PG 16 WC Public, Environmental & Occupational Health; Sport Sciences SC Public, Environmental & Occupational Health; Sport Sciences GA TN551 UT WOS:A1995TN55100006 ER PT J AU MOUL, JW SESTERHENN, IA CONNELLY, RR DOUGLAS, T SRIVASTAVA, S MOSTOFI, FK MCLEOD, DG AF MOUL, JW SESTERHENN, IA CONNELLY, RR DOUGLAS, T SRIVASTAVA, S MOSTOFI, FK MCLEOD, DG TI PROSTATE-SPECIFIC ANTIGEN VALUES AT THE TIME OF PROSTATE-CANCER DIAGNOSIS IN AFRICAN-AMERICAN MEN SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article AB Objective.-To determine if African-American men with newly diagnosed prostate cancer (PC) have higher pretreatment serum prostate-specific antigen (PSA) values after adjustment for clinical stage, age, and tumor grade, and to determine if any difference detected is related to tumor volume difference. Design.-Consecutive case series of newly diagnosed PC patients between January 1990 and September 1994 and cohort analytic study of PC patients treated by radical prostatectomy (RP) and who had whole-mount pathologic tumor volume assessment between May 1993 December 1994. Setting.-Tertiary care military medical center. Patients.-A total of 541 evaluable newly diagnosed PC patients (408 white and 133 black) having pretreatment PSA assessment at one laboratory; 91 patients undergoing RP had whole-mount tumor volume analysis. Interventions.-Medical record review for pretreatment PSA value, race, tumor grade, clinical stage, and age, as well as whole-mount pathologic assessment of RP specimen and measurement of tumor volume. Main Outcome Measures.-The PSA differences between black and white PC patients with adjustments for age, biopsy tumor grade (Gleason score), and clinical stage (TNM stage); PSA differences between black and white PC patients undergoing RP with adjustment for age, RP grade, clinical stage, and tumor volume. Results.-The mean (geometric) PSA value for 133 black men was 14.00 ng/mL compared with 8.29 ng/mL for 408 white men (P<.001). The black patients had higher PSA values across all stage, grade, and age categories. The racial difference in PSA levels remained statistically significant when stage, grade, and age were simultaneously controlled for (P<.001). Multivariable odds ratio testing revealed that even after adjustment for stage, grade, and age, black patients were 2.2 times as likely as white patients to have a PSA value greater than 10.0 ng/mL (95% confidence interval, 1.3 to 3.6). Tumor volume (geometric mean) was 5.42 cm(3) and 2.10 cm(3) for black and white RP patients, respectively (P=.002). Across all clinical stages (T1a to T3), black men had tumor volumes 1.3 to 2.5 times greater than those of white men. Multivariable analysis of covariance revealed that tumor volume and stage of disease were important predictors of PSA level, but race, grade, and age were not. (The percentage of white and black patients whose cancer was detected by screening [75.4% vs 70.4%] or who had symptoms [37.7% vs 29.6%] was not significantly different.) Conclusions.-As a group, African-American men with newly diagnosed PC have higher PSA values at initial diagnosis than white men. This PSA difference appears to be due to larger tumor volumes within clinical (TNM) stage categories among black patients. Elevated PSA value was a surrogate for larger tu mor volume in this cohort of black men. This stage-for-stage tumor volume disparity even in an equal-access health care environment should prompt further study of screening behavior and/or biological differences of PC in the black population. C1 WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,DEPT GENITOURINARY PATHOL,WASHINGTON,DC 20306. RP MOUL, JW (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,CTR PROSTATE DIS RES,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 16 TC 203 Z9 208 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD OCT 25 PY 1995 VL 274 IS 16 BP 1277 EP 1281 DI 10.1001/jama.274.16.1277 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA TA104 UT WOS:A1995TA10400022 PM 7563532 ER PT J AU REN, F HOBSON, WS LOTHIAN, JR LOPATA, J CABALLERO, JA PEARTON, SJ COLE, MW AF REN, F HOBSON, WS LOTHIAN, JR LOPATA, J CABALLERO, JA PEARTON, SJ COLE, MW TI HIGH-RATE DRY-ETCHING OF INGAP IN BCL3 PLASMA CHEMISTRIES SO APPLIED PHYSICS LETTERS LA English DT Article ID VAPOR-PHASE EPITAXY; GAAS AB A remarkable increase in InGaP etch rate in electron cyclotron resonance BCl3 discharges is observed as the microwave power is increased from 250 W (etch rate similar to 500 Angstrom/min) to 1000 W (etch rate similar to 8000 Angstrom/min). The surface roughness measured by atomic force microscopy decreases from 36 nm at 250 W to 2 nm at 1000 W. The high ion flux incident on the InGaP at high microwave powers appears to remove InClx species by sputter-assisted desorption and prevents formation of the nonstoichiometric In-rich surfaces generally observed with Cl-2-based dry etching using conventional reactive ion etching. (C) 1995 American Institute of Physics. C1 UNIV FLORIDA,GAINESVILLE,FL 32611. USA,RES LAB,FT MONMOUTH,NJ. RP REN, F (reprint author), AT&T BELL LABS,600 MT AVE,MURRAY HILL,NJ 07974, USA. NR 17 TC 43 Z9 43 U1 2 U2 4 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 23 PY 1995 VL 67 IS 17 BP 2497 EP 2499 DI 10.1063/1.114437 PG 3 WC Physics, Applied SC Physics GA TA581 UT WOS:A1995TA58100024 ER PT J AU RICKLIN, JC MILLER, WB ANDREWS, LC AF RICKLIN, JC MILLER, WB ANDREWS, LC TI EFFECTIVE BEAM PARAMETERS AND THE TURBULENT BEAM WAIST FOR CONVERGENT GAUSSIAN BEAMS SO APPLIED OPTICS LA English DT Article AB Expressions are developed for the location and the size of the beam waist for a convergent Gaussian beam in statistically homogeneous and isotropic atmospheric turbulence. Subsidiary expressions are presented that lead to the maximum distance from the transmitter at which the beam waist can be located under given optical turbulence conditions and the optimal initial radius of curvature required for placing the beam waist at a desired location. The free-space beam radius W of a Gaussian beam satisfies the relationship partial derivative W/partial derivative z = -W/R, where z represents the path length and R is the phase-front radius of curvature at z. By enforcing this relation on the effective beam spot size in turbulence W-e, we can define an effective radius of curvature R(e). In addition to specifying the beam waist, R(e) leads to a pair of effective beam parameters theta(e) and Lambda(e) that provide a natural extension to the complex amplitude plane. Within this context, general propagation characteristics may be described, including the coherence properties of a Gaussian beam in both weak and strong optical turbulence. C1 USA,RES LAB,BATTLEFIELD ENVIRONM DIRECTORATE,WHITE SANDS MISSILE RANGE,NM 88002. RP RICKLIN, JC (reprint author), UNIV CENT FLORIDA,DEPT MATH,ORLANDO,FL 32816, USA. NR 20 TC 13 Z9 14 U1 1 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD OCT 20 PY 1995 VL 34 IS 30 BP 7059 EP 7065 PG 7 WC Optics SC Optics GA RZ268 UT WOS:A1995RZ26800032 PM 21060567 ER PT J AU MILLER, WB RICKLIN, JC ANDREWS, LC AF MILLER, WB RICKLIN, JC ANDREWS, LC TI SCINTILLATION OF INITIALLY CONVERGENT GAUSSIAN BEAMS IN THE VICINITY OF THE GEOMETRIC FOCUS SO APPLIED OPTICS LA English DT Article ID TURBULENT AB As an initially convergent Gaussian beam enters the vicinity of the geometric focus, weak fluctuation theory predicts a drop in the longitudinal component of the log-irradiance variance and an increase in the radial component off the beam center. The phenomenon intensifies as the beam nears the geometric focus, also with decreasing magnitude of the focusing parameter. Precisely at the geometric focus, first-order weak fluctuation theory further predicts that as the initial beam size continues to increase, the longitudinal component of the log-irradiance variance decreases toward zero, while the radial component increases without bound. This eventually entails a rapid change in scintillation across the beam surface that has yet to be verified experimentally, to our knowledge. We demonstrate that when diffraction like effects produced by optical turbulence are introduced, predicted log-irradiance variance exhibits such extremes in behavior only in the case of weak turbulence. Also, at the exact geometric focus, scintillation does not vanish with increasing initial beam size but achieves a value determined by and growing with turbulence strength and nearly independent of initial beam size. The radial component of log-irradiance quickly loses significance as turbulence strength increases. In fact, general extremal behavior of the log-irradiance variance in the vicinity of the geometric focus is drastically curtailed. Differences across the diffractive beam surface become small and exhibit only a modest dependence on the initial beam size. (C) 1995 Optical Society of America C1 UNIV CENT FLORIDA,DEPT MATH,ORLANDO,FL 32816. UNIV CENT FLORIDA,CTR RES EDUC OPT & LASERS,ORLANDO,FL 32816. RP MILLER, WB (reprint author), USA,RES LAB,BATTLEFIELD DIRECTORATE,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 21 TC 5 Z9 5 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD OCT 20 PY 1995 VL 34 IS 30 BP 7066 EP 7073 PG 8 WC Optics SC Optics GA RZ268 UT WOS:A1995RZ26800033 PM 21060568 ER PT J AU HILL, SC PINNICK, RG NACHMAN, P CHEN, G CHANG, RK MAYO, MW FERNANDEZ, GL AF HILL, SC PINNICK, RG NACHMAN, P CHEN, G CHANG, RK MAYO, MW FERNANDEZ, GL TI AEROSOL-FLUORESCENCE SPECTRUM ANALYZER - REAL-TIME MEASUREMENT OF EMISSION-SPECTRA OF AIRBORNE BIOLOGICAL PARTICLES SO APPLIED OPTICS LA English DT Article ID PROTEIN TRYPTOPHAN FLUORESCENCE; STEADY-STATE; DECAY CHARACTERISTICS; RESONANCES; BACTERIA; RATES AB We have assembled an aerosol-fluorescence spectrum analyzer (AFS), which can measure the fluorescence spectra and elastic scattering of airborne particles as they flow through a laser beam. The aerosols traverse a scattering cell where they are illuminated with intense (50 kW/cm(2)) light inside the cavity of an argon-ion laser operating at 488 nm. This AFS can obtain fluorescence spectra of individual dye-doped polystyrene microspheres as small as 0.5 mu m in diameter. The spectra obtained from microspheres doped with pink and green-yellow dyes are clearly different. We have also detected the fluorescence spectra of airborne particles (although not single particles) made from various biological materials, e.g., Bacillus subtilis spores, B. anthrasis spores, riboflavin, and tree leaves. The AFS may be useful in detecting and characterizing airborne bacteria and other airborne particles of biological origin. (C) 1995 Optical Society of America C1 YALE UNIV,DEPT APPL PHYS,NEW HAVEN,CT 06520. YALE UNIV,CTR LASER DIAGNOST,NEW HAVEN,CT 06520. USAF,ARMSTRONG LAB,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. NEW MEXICO STATE UNIV,DEPT PHYS,LAS CRUCES,NM 88003. RP HILL, SC (reprint author), USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 34 TC 48 Z9 50 U1 2 U2 13 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD OCT 20 PY 1995 VL 34 IS 30 BP 7149 EP 7155 PG 7 WC Optics SC Optics GA RZ268 UT WOS:A1995RZ26800042 PM 21060577 ER PT J AU VLADIMIROFF, T AF VLADIMIROFF, T TI AN AB-INITIO STUDY OF THE STRUCTURE, VIBRATIONAL FREQUENCIES AND FORCE-FIELD FOR THE SYMMETRICAL FORM OF N2O3 SO THEOCHEM-JOURNAL OF MOLECULAR STRUCTURE LA English DT Article ID GF MATRIX-METHOD; DINITROGEN TETROXIDE; EXCHANGE-ENERGY; ISOMERIC FORMS; APPROXIMATION; TRIOXIDE; ACCURATE AB In this work the structure of symmetric N2O3 was investigated using ab initio methods. Bond lengths and bond angles were determined using the 6-31G* and the 6-311G* basis sets and both SCF and MP2 theory. At the highest level of theory considered, the N-O bond was determined to be 1.492 Angstrom, the N=O bond was 1.168 Angstrom, the N-O-N angle was 103.5 degrees and the O=N-O bond angle was found to be 109.9 degrees. The molecule was determined to be planar at all levels of theory considered. Vibrational frequencies were computed for the symmetric structure of N2O3 at the 6-31G*/MP2 level of theory. The calculated vibrational frequencies are in better agreement with the alternate assignments than the preferred assignments reported previously. A new force field was derived for this molecule by starting with the theoretical values and making small adjustments in such a way as to reproduce the experimentally observed vibrational frequencies. An attempt was made to determine the relative stability of the symmetric and asymmetric forms of this molecule. Results are also compared with recent density functional calculations on these molecules. RP VLADIMIROFF, T (reprint author), USA, ARDEC, ARMAMENT ENGN DIRECTORATE, BLDG 3124, PICATINNY ARSENAL, NJ 07806 USA. NR 25 TC 1 Z9 1 U1 1 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 THEOCHEM-J MOL STRUC JI Theochem-J. Mol. Struct. PD OCT 20 PY 1995 VL 342 BP 103 EP 108 DI 10.1016/0166-1280(95)04212-O PG 6 WC Chemistry, Physical SC Chemistry GA TD910 UT WOS:A1995TD91000012 ER PT J AU SALMINEN, MO KOCH, C SANDERSBUELL, E EHRENBERG, PK MICHAEL, NL CARR, JK BURKE, DS MCCUTCHAN, FE AF SALMINEN, MO KOCH, C SANDERSBUELL, E EHRENBERG, PK MICHAEL, NL CARR, JK BURKE, DS MCCUTCHAN, FE TI RECOVERY OF VIRTUALLY FULL-LENGTH HIV-1 PROVIRUS OF DIVERSE SUBTYPES FROM PRIMARY VIRUS CULTURES USING THE POLYMERASE CHAIN-REACTION SO VIROLOGY LA English DT Article ID PHYLOGENETIC ANALYSIS; DNA-POLYMERASE; INVIVO; EXPRESSION; INFECTION; SEQUENCES; FIDELITY AB In the course of the global pandemic, the human immunodeficiency virus type-1 (HIV-1) has established at least eight distinct genotypes in the main (M), or prevalent, group of isolates, a variety of rare outlier forms, and intergenotypic recombinants of group M viruses. This genotypic diversity has been documented, for the most part, by sequencing of subgenomic segments of the provirus. Using DNA from virus cultures on peripheral blood mononuclear cells (PBMC) and recent improvements of the PCR technique, we have amplified virtually full-length HIV-I genomes from genetic subtypes A through G of group M viruses and molecularly cloned several of them. Resequencing of the complete genome of a prototype strain after long PCR amplification and cloning has established a PCR error rate of 0.14%. We also report the first complete PCR-derived sequence of a U.S. clinical isolate of genotype a expanded only in primary PBMC; this provirus harbors a uniquely truncated V3 loop. (C) 1995 Academic Press, Inc. C1 WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD 20850. RP SALMINEN, MO (reprint author), HENRY M JACKSON FDN ADVANCEMENT MIL MED,1600 E GUDE DR,ROCKVILLE,MD 20850, USA. RI Salminen, Mika/D-8784-2013; OI Salminen, Mika/0000-0003-3020-0866; /0000-0002-5704-8094 NR 31 TC 142 Z9 147 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD OCT 20 PY 1995 VL 213 IS 1 BP 80 EP 86 DI 10.1006/viro.1995.1548 PG 7 WC Virology SC Virology GA TA440 UT WOS:A1995TA44000009 PM 7483282 ER PT J AU WANG, SG HE, RT PATARAPOTIKUL, J INNIS, BL ANDERSON, R AF WANG, SG HE, RT PATARAPOTIKUL, J INNIS, BL ANDERSON, R TI ANTIBODY-ENHANCED BINDING OF DENGUE-2 VIRUS TO HUMAN PLATELETS SO VIROLOGY LA English DT Note ID IGG-FC RECEPTOR; MONOCLONAL-ANTIBODIES; INFECTION; PROTEIN; GLYCOPROTEIN; FLAVIVIRUS; QUININE AB The mechanisms underlying severe thrombocytopenia in dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) are not completely understood. We present here the first evidence that dengue type 2 virus binds to human platelets only in the presence of virus-specific antibody, supporting a role for immune-mediated clearance of platelets in the pathogenesis of thrombocytopenia in DHF/DSS. Antibody-enhanced binding of virus of platelets was also demonstrated with a panel of eight murine monoclonal antibodies specific for the dengue E protein. The degree of binding was dependent on the antibody used but not on the antibody IgG subclass, indicating that factors other than the platelet Fc receptor are involved in binding of virus-antibody complexes to the platelet suriace. Confirmation that antibody-dependent virus binding to platelets is not primarily mediated by the platelet Fe receptor was obtained by demonstrating good binding even when platelets were pretreated with the Fc gamma RII-specific antibody IV.3. (C) 1995 Academic Press, Inc. C1 DALHOUSIE UNIV,DEPT MICROBIOL & IMMUNOL,HALIFAX,NS B3H 4H7,CANADA. MAHIDOL UNIV,FAC TROP MED,DEPT MICROBIOL & IMMUNOL,BANGKOK,THAILAND. ARMED FORCES RES INST MED SCI,DEPT VIROL,BANGKOK 10400,THAILAND. NR 33 TC 67 Z9 72 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD OCT 20 PY 1995 VL 213 IS 1 BP 254 EP 257 DI 10.1006/viro.1995.1567 PG 4 WC Virology SC Virology GA TA440 UT WOS:A1995TA44000028 PM 7483271 ER PT J AU BLAIS, MS RAUSCH, MD AF BLAIS, MS RAUSCH, MD TI A NEW SYNTHETIC ROUTE TO FUNCTIONALLY-SUBSTITUTED (ETA(5)-CYCLOPENTADIENYL)DICARBONYLIRIDIUM COMPOUNDS SO JOURNAL OF ORGANOMETALLIC CHEMISTRY LA English DT Article DE IRIDIUM; SUBSTITUTED (CYCLOPENTADIENYL)DICARBONYLIRIDIUM COMPOUNDS; SYNTHESIS; C-13 NMR SPECTRA; HAMMETT SUBSTITUENT PARAMETERS ID MOLECULAR-STRUCTURE; CRYSTAL-STRUCTURE; CONSTANTS; CYCLOPENTADIENYLTHALLIUM; DERIVATIVES; ACTIVATION; PARAMETERS; UTILITY AB A series of functionally substituted (eta(5)-cyclopentadienyl)dicarbonyliridium compounds have been prepared from reactions of the corresponding substituted cyclopentadienyl-sodium, -lithium, or -thallium reagents with chlorodicarbonyl(pyridine)iridium. Ring-substituted compounds synthesized by this route include chloro, benzyl, pentabenzyl, acetyl, carbomethoxy, methyl, benzoyl, trimethylsilyl, cyano, dimethylamino, tetraphenyl, dimethylaminoethyl, (tetramethyl)dimethylaminoethyl, methoxyethyl and pentamethyl. The symmetric and asymmetric carbonyl stretching frequencies as well as the C-13 NMR chemical shifts of the carbonyl substituents have been correlated with various Hammett substituent parameters. C1 UNIV MASSACHUSETTS,DEPT CHEM,AMHERST,MA 01003. US MIL ACAD,DEPT CHEM,W POINT,NY 10996. NR 27 TC 17 Z9 17 U1 0 U2 0 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0022-328X J9 J ORGANOMET CHEM JI J. Organomet. Chem. PD OCT 18 PY 1995 VL 502 IS 1-2 BP 1 EP 8 DI 10.1016/0022-328X(95)05627-2 PG 8 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA TA555 UT WOS:A1995TA55500002 ER PT J AU ZUBER, M HOOVER, TA DERTZBAUGH, MT COURT, DL AF ZUBER, M HOOVER, TA DERTZBAUGH, MT COURT, DL TI ANALYSIS OF THE DNAK MOLECULAR CHAPERONE SYSTEM OF FRANCISELLA-TULARENSIS SO GENE LA English DT Article DE TULAREMIA; CAPSULE; VIRULENCE; DNAJ; GRPE; HEAT-SHOCK PROTEIN ID LIVE VACCINE STRAIN; HEAT-SHOCK GENE; POLYMORPHONUCLEAR LEUKOCYTES; MACROPHAGES; SEQUENCE; IMMUNITY AB We have cloned the Francisella tularensis (Ft) grpE-dnaK-dnaJ heat-shock genes which are organized in that order. These genes allow heterologous genetic complementation of each respective mutant strain of Escherichia coli (Ec) for bacteriophage lambda growth. The nucleotide sequences of the Ft grpE-dnaK-dnaJ genes and the deduced amino-acid sequences share significant homologies with their respective Ec counterparts. The Ft DnaK and DnaJ proteins crossreact with polyclonal antibodies raised against the respective Ec proteins, The grpE-dnaK-dnaJ genes of Ft are organized in a fashion that is more characteristic of Gram(+) bacteria. C1 USA, MED RES INST INFECT DIS, DIV BACTERIOL, FREDERICK, MD 21702 USA. NCI, FREDERICK CANC RES & DEV CTR, DIV TOXICOL, FREDERICK, MD 21702 USA. RP NCI, FREDERICK CANC RES & DEV CTR, CHROMOSOME BIOL LAB, MOLEC CONTROL & GENET SECT, FREDERICK, MD 21702 USA. NR 20 TC 21 Z9 24 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-1119 EI 1879-0038 J9 GENE JI Gene PD OCT 16 PY 1995 VL 164 IS 1 BP 149 EP 152 DI 10.1016/0378-1119(95)00489-S PG 4 WC Genetics & Heredity SC Genetics & Heredity GA TC459 UT WOS:A1995TC45900027 PM 7590305 ER PT J AU MANKA, AS DOWLING, JP BOWDEN, CM FLEISCHHAUER, M AF MANKA, AS DOWLING, JP BOWDEN, CM FLEISCHHAUER, M TI PIEZOPHOTONIC SWITCHING DUE TO LOCAL-FIELD EFFECTS IN A COHERENTLY PREPARED MEDIUM OF 3-LEVEL ATOMS - REPLY SO PHYSICAL REVIEW LETTERS LA English DT Note ID QUANTUM COHERENCE; ENHANCEMENT; INDEX C1 UNIV MUNICH,DEPT PHYS,D-80333 MUNICH,GERMANY. RP MANKA, AS (reprint author), USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898, USA. RI Fleischhauer, Michael/G-6716-2011; DOWLING, JONATHAN/L-2749-2013 NR 8 TC 0 Z9 0 U1 0 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD OCT 16 PY 1995 VL 75 IS 16 BP 3025 EP 3025 DI 10.1103/PhysRevLett.75.3025 PG 1 WC Physics, Multidisciplinary SC Physics GA RZ341 UT WOS:A1995RZ34100033 ER PT J AU JATOI, I AF JATOI, I TI MAMMOGRAPHIC SCREENING FOR WOMEN 40 TO 49 YEARS OF AGE SO ANNALS OF INTERNAL MEDICINE LA English DT Letter ID CANCER RP JATOI, I (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD OCT 15 PY 1995 VL 123 IS 8 BP 634 EP 635 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA RY828 UT WOS:A1995RY82800019 PM 7677311 ER PT J AU MEGO, DM NOTTESTAD, SY LAMANNA, VP ONESCHUK, LC MOODY, JM RUBAL, BJ ZABALGOITIA, M AF MEGO, DM NOTTESTAD, SY LAMANNA, VP ONESCHUK, LC MOODY, JM RUBAL, BJ ZABALGOITIA, M TI COLOR DOPPLER M-MODE ASSESSMENT OF LEFT-VENTRICULAR FILLING IN NORMAL INDIVIDUALS - VARIATION OF FLOW PROPAGATION VELOCITY WITH AGE SO CIRCULATION LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 76284. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 15 PY 1995 VL 92 IS 8 SU S BP 68 EP 68 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA TB480 UT WOS:A1995TB48000065 ER PT J AU CARTER, AJ HICKS, K HELDMAN, AW RESAR, JR LAIRD, JR COOMBS, VJ BRINKER, JA BLUMENTHAL, RS AF CARTER, AJ HICKS, K HELDMAN, AW RESAR, JR LAIRD, JR COOMBS, VJ BRINKER, JA BLUMENTHAL, RS TI CLINICAL VALIDATION OF A MICROSAMPLE COAGULATION ANALYZER AND COMPARISON WITH EXISTING TECHNIQUES SO CIRCULATION LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. JOHNS HOPKINS UNIV,BALTIMORE,MD. RI Heldman, Alan/K-8784-2012 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 15 PY 1995 VL 92 IS 8 SU S BP 3780 EP 3780 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA TB480 UT WOS:A1995TB48003756 ER PT J AU KIANG, JG AF KIANG, JG TI MYSTIXIN-7 AND MYSTIXIN-11 INCREASE CYTOSOLIC-FREE CA2+ AND INOSITOL TRISPHOSPHATES IN HUMAN A-431 CELLS SO EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION LA English DT Article DE CORTICOTROPIN RELEASING FACTOR; CA2+; CA2+ CHANNEL; PERTUSSIS TOXIN; INOSITOL TRISPHOSPHATE; EPITHELIUM ID CORTICOTROPIN-RELEASING FACTOR; SIGNAL TRANSDUCTION; PITUITARY-CELLS; INJURY; RECEPTOR; PROTEINS; CALCIUM; RATS AB Mystixin-7 and mystixin-11, small peptides structurally related to corticotropin-releasing factor (CRF), have been shown to attenuate vascular leakage in injured skin. The goal of this study was to characterize changes in cytosolic Ca2+ concentration ([Ca2+](i)) in human epidermoid A-431 cells treated with these two peptides and to investigate the mechanisms by which these changes occurred. The resting [Ca2+](i) in A-431 cells at 37 degrees C was 76 +/- 2 nM (n = 373). When cells were treated with either peptide, [Ca2+](i) increased immediately. The increase depended on the peptide concentration, with a median effective concentration of 299 +/- 9 pM for mystixin-7 and 2.23 +/- 0.04 pM for mystixin-11. The increases also depended on extracellular Ca2+ and were blocked by Cd2+, Co2+, verapamil, and nifedipine. alpha-Helical CRF-(9-41), a synthetic CRF receptor antagonist, and pertussis toxin also blocked the increase in [Ca2+](i) induced by the two peptides. Taken together, these results suggest that mystixin-7 and mystixin-11 interact with CRF receptors to activate pertussis-sensitive G proteins coupled to L-type Ca2+ channels that allow an uptake of extracellular Ca2+. Because U-73122, an inhibitor of 1,4,5-inositol trisphosphate production, partially inhibited the increase in [Ca2+](i), we measured inositol trisphosphates in cells stimulated by the two peptides. Both increased inositol trisphosphate levels within 1 min. The increase was inhibited by the removal of extracellular Ca2+ or treatment with U-73122. The results suggest that the Ca2+ influx stimulated by mystixin-7 and mystixin-11 induces an increase in inositol trisphosphates, resulting in a mobilization of Ca2+ from 1,4,5-inositol trisphosphate-sensitive Ca2+ pools. RP KIANG, JG (reprint author), WALTER REED ARMY MED CTR,DEPT CLIN PHYSIOL,DIV MED,WASHINGTON,DC 20307, USA. NR 24 TC 6 Z9 7 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0922-4106 J9 EUR J PHARM-MOLEC PH JI Eur. J. Pharmacol.-Molec. Pharmacol. Sect. PD OCT 15 PY 1995 VL 291 IS 2 BP 107 EP 113 DI 10.1016/0922-4106(95)90131-0 PG 7 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA TD530 UT WOS:A1995TD53000007 PM 8566159 ER PT J AU NAMBURU, RR TURNER, DA TAMMA, KK AF NAMBURU, RR TURNER, DA TAMMA, KK TI AN EFFECTIVE DATA-PARALLEL SELF-STARTING EXPLICIT METHODOLOGY FOR COMPUTATIONAL STRUCTURAL DYNAMICS ON THE CONNECTION MACHINE CM-5 SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING LA English DT Article DE DATA PARALLEL COMPUTER; EXPLICIT TIME INTEGRATION; FINITE ELEMENT METHOD; STRUCTURAL DYNAMICS; LINEAR AND NONLINEAR PROBLEMS ID SUPERCOMPUTER AB This paper discusses the implementation aspects and our experiences towards a data parallel explicit self-starting finite element transient methodology with emphasis on the Connection Machine (CM-5) for linear and non-linear computational structural dynamic applications involving structured and unstructured grids. The parallel implementation criteria that influence the efficiency of an algorithm include the amount of communication, communication routing, and load balancing. To provide simplicity, high level of accuracy, and to retain the generality of the finite element implementation for both linear and non-linear transient explicit problems on a data parallel computer which permit optimum amount of communications, we implemented the present self-starting dynamic formulations (in comparison to the traditional approaches) based on nodal displacements, nodal velocities, and elemental stresses on the CM-5. Data parallel language CMFortran is employed with virtual processor constructs and with:SERIAL and:PARALLEL layout directives for arrays. The communications via the present approach involve only one gather operation (extraction of element nodal displacements or velocities from global displacement vector) and one scatter operation (dispersion of element forces onto global force vector) for each time step. These gather and scatter operations are implemented using the Connection Machine Scientific Software Library communication primitives for both structured and unstructured finite element meshes. The implementation aspects of the present self-starting formulations for linear and elastoplastic applications oil serial and data parallel machines are discussed. Numerical test models for linear and non-linear one-dimensional applications and a two-dimensional unstructured finite element mesh are then illustrated and their performance studies are discussed. C1 UNIV MINNESOTA, MINNEAPOLIS, MN 55455 USA. RP NAMBURU, RR (reprint author), USA, TARDEC, AMSTA RYT, ARMY HIGH PERFORMANCE COMP RES CTR, BLDG 215, WARREN, MI 48379 USA. NR 19 TC 7 Z9 8 U1 0 U2 2 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0029-5981 J9 INT J NUMER METH ENG JI Int. J. Numer. Methods Eng. PD OCT 15 PY 1995 VL 38 IS 19 BP 3211 EP 3226 DI 10.1002/nme.1620381903 PG 16 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA RX070 UT WOS:A1995RX07000002 ER PT J AU GOLDSMITH, BJ SHRIEVE, DC LOEFFLER, JS AF GOLDSMITH, BJ SHRIEVE, DC LOEFFLER, JS TI HIGH EFFICACY WITHOUT VISUAL DAMAGE - THE CURRENT STATUS OF PITUITARY RADIOTHERAPY SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Editorial Material ID RADIATION-THERAPY; ADENOMAS; HEADACHE C1 HARVARD UNIV,SCH MED,JOINT CTR RADIAT THERAPY,BOSTON,MA 02115. TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859. NR 21 TC 3 Z9 3 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PD OCT 15 PY 1995 VL 33 IS 3 BP 765 EP 767 DI 10.1016/0360-3016(95)02127-W PG 3 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA TA483 UT WOS:A1995TA48300028 PM 7558970 ER PT J AU SRINIVASAN, R HALL, RR LOEHLE, WD WILSON, WD ALLBEE, DC AF SRINIVASAN, R HALL, RR LOEHLE, WD WILSON, WD ALLBEE, DC TI CHEMICAL-TRANSFORMATIONS OF THE POLYIMIDE KAPTON BROUGHT ABOUT BY ULTRAVIOLET-LASER RADIATION SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID ABLATION; FILMS; POLYMERS; PRODUCTS; CARBON; ABSORPTION; THRESHOLD; GRAPHITE; UV AB By the use of ultraviolet laser pulses of microsecond and millisecond duration it is shown that the chemistry of the transformations of Kapton by UV laser radiation is strongly dependent on the intensity (power/unit area) of the laser beam. With these long pulses, the polymer was not ablated. The decomposition resulted in 51% of the polymer weight being converted to gaseous products consisting mostly of CO (67%), HCN (15%), C2H2 (12%), and some (<5%) CO2. The major solid product that remained was ''glassy'' carbon which was identified from its Raman spectrum. This material can be viewed as the product of the secondary addition reactions of the residue that is left after the loss of the gaseous products listed above. With 20 ms pulses, the evolution of the gaseous products increased linearly with intensity and the product composition was constant within the experimental uncertainty over a 12-fold range of intensity up to 50 kW/cm(2) (=1 kJ/cm(2)). These results show that pulses of duration much greater than ns do not lead to ablation even at fluences that are 10(4) greater than the threshold for ablation using nanosecond pulses. It is therefore more appropriate to view the ablation of this polymer by UV laser pulses of nanosecond duration as being due to the scaling of an intensity threshold rather than a fluence threshold as has become the practice. (C) 1995 American institute of Physics. C1 US MIL ACAD,PHOTON RES CTR,W POINT,NY 10966. US MIL ACAD,DEPT CHEM,W POINT,NY 10966. RP SRINIVASAN, R (reprint author), UVTECH ASSOCIATES,98 CEDAR LANE,OSSINING,NY 10562, USA. NR 37 TC 49 Z9 49 U1 1 U2 11 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD OCT 15 PY 1995 VL 78 IS 8 BP 4881 EP 4887 DI 10.1063/1.359776 PG 7 WC Physics, Applied SC Physics GA RY396 UT WOS:A1995RY39600011 ER PT J AU KRZYCH, U LYON, JA JAREED, T SCHNEIDER, I HOLLINGDALE, MR GORDON, DM AF KRZYCH, U LYON, JA JAREED, T SCHNEIDER, I HOLLINGDALE, MR GORDON, DM TI T-LYMPHOCYTES FROM VOLUNTEERS IMMUNIZED WITH IRRADIATED PLASMODIUM-FALCIPARUM SPOROZOITES RECOGNIZE LIVER AND BLOOD-STAGE MALARIA ANTIGENS SO JOURNAL OF IMMUNOLOGY LA English DT Article ID MEROZOITE SURFACE-ANTIGEN; CIRCUMSPOROZOITE PROTEIN; INFECTED ERYTHROCYTES; PROTECTIVE IMMUNITY; CELL CLONES; CS PROTEIN; BERGHEI; EXPRESSION; EPITOPES; GENE AB The model of protective immunity induced by immunization with irradiated plasmodia sporozoites (SPZ) has become the prototype for a promising vaccine strategy based on Ab and CTL responses directed against pre-erythrocytic stage Ags, in particular the circumsporozoite protein (CSP) and sporozoite surface protein 2 (SSP2). However, results from recently conducted vaccine studies suggest that T cell responses directed against additional specificities might also be required for protection. We have tested this hypothesis by examining human T lymphocytes from irradiated Plasmodium falciparum SPZ-immune volunteers for proliferative reactivities to parasitized red blood cells (pRBC) and recombinant proteins and synthetic peptides representing certain liver and blood stage Ags. In this work, we report that although SPZ-induced protective immunity is stage-specific, SPZ-immune lymphocytes recognized determinants associated with erythrocytic and liver stage parasites. Thus, protective immunity induced by irradiated SPZ may depend upon responses against pre-erythrocytic Ags in addition to CSP and SSP2. C1 WALTER REED ARMY INST RES,DEPT ENTOMOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. US FDA,CTR BIOL EVALUAT & RES,DIV ALLERG PROD & PARASITOL,BETHESDA,MD 20852. RP KRZYCH, U (reprint author), WALTER REED ARMY INST RES,DEPT IMMUNOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307, USA. NR 57 TC 66 Z9 67 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD OCT 15 PY 1995 VL 155 IS 8 BP 4072 EP 4077 PG 6 WC Immunology SC Immunology GA RY581 UT WOS:A1995RY58100048 PM 7561118 ER PT J AU VANCOTT, TC BETHKE, FR BURKE, DS REDFIELD, RR BIRX, DL AF VANCOTT, TC BETHKE, FR BURKE, DS REDFIELD, RR BIRX, DL TI LACK OF INDUCTION OF ANTIBODIES SPECIFIC FOR CONSERVED, DISCONTINUOUS EPITOPES OF HIV-1 ENVELOPE GLYCOPROTEIN BY CANDIDATE AIDS VACCINES SO JOURNAL OF IMMUNOLOGY LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; HUMAN MONOCLONAL-ANTIBODY; BIOSPECIFIC INTERACTION ANALYSIS; CD4 BINDING-SITE; SOLUBLE CD4; NEUTRALIZING ANTIBODIES; RECOMBINANT GP160; CONFORMATIONAL EPITOPE; OLIGOMERIC STRUCTURE; CD4-BINDING SITE AB We examined the humoral immune response in both HIV-1 infected and uninfected volunteers immunized with candidate HIV-1 recombinant envelope subunit vaccines (Genetech gp120(IIIB), MicroGeneSys gp160(IIIB), or ImmunoAG gp160(IIIB)). Immunization of both HIV-1 infected and uninfected volunteers with these immunogens resulted in the induction of Abs preferentially reactive with epitopes accessible on a denatured form of gp120. While sera from HIV-1 uninfected gp120/gp160(IIIB) vaccinees bound gp120/gp41, which was expressed on the surface of H9 cells infected with HIV-1(IIIB), minimal binding to HIV-1(MN) or HIV-1(RF) infected cells was obtained. Induction of qualitatively similar immune responses by these immunogens would not have been predicted based on their different tertiary structures. These data indicate a restriction of the immune response to linear, conserved epitopes poorly accessible on both monomeric gp120 and cell-surface expressed oligomeric gp120/gp41 and a lack of Abs specific for conformational epitopes conserved across divergent HIV-1 strains. Poor recognition of HIV-1 envelope tertiary and quaternary structure may explain the restricted neutralization profiles of vaccinee sera against laboratory-adapted strains of HIV-1 and their inability to neutralize primary HIV-1 isolates. Alternate immunogens or reformulations with the capacity to elicit Abs that preferentially bind to natively folded gp120 should be investigated and correlated with their ability to neutralize more diverse laboratory-adapted and primary HIV-1 isolates. C1 HENRY M JACKSON FDN,ROCKVILLE,MD 20850. RP VANCOTT, TC (reprint author), WALTER REED ARMY INST RES,DIV RETROVIROL,13 TAFT CT,SUITE 200,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 NR 92 TC 79 Z9 80 U1 0 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD OCT 15 PY 1995 VL 155 IS 8 BP 4100 EP 4110 PG 11 WC Immunology SC Immunology GA RY581 UT WOS:A1995RY58100053 PM 7561123 ER PT J AU IAFRATE, GJ HESS, K KRIEGER, JB MACUCCI, M AF IAFRATE, GJ HESS, K KRIEGER, JB MACUCCI, M TI CAPACITIVE NATURE OF ATOMIC-SIZED STRUCTURES SO PHYSICAL REVIEW B LA English DT Note AB The capacitance of an N-electron system is established by deriving the atomistic connection between the capacitive energy, the ionization potential, and the electron affinity of the charged system; it is shown further that this connection leads to the linkage of the capacitive energy to the difference between the lowest unoccupied and the highest occupied Kohn-Sham orbital energies of the system. An illustrative example is used to show explicitly the microscopic behavior of the derived capacitance for a finite electron system, and to discuss the tendency of the derived capacitance to limit toward the classical electrostatic capacitance as the system becomes macroscopically large. Discussions relevant to atomic and molecular systems are included. C1 UNIV ILLINOIS,BECKMAN INST,URBANA,IL 61801. CUNY BROOKLYN COLL,BROOKLYN,NY 11210. UNIV PISA,DIPARTIMENTO INGN INFORMAZ,I-56126 PISA,ITALY. RP IAFRATE, GJ (reprint author), USA,RES OFF,RES TRIANGLE PK,NC 27709, USA. OI Macucci, Massimo/0000-0002-7943-2441 NR 13 TC 56 Z9 57 U1 0 U2 4 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD OCT 15 PY 1995 VL 52 IS 15 BP 10737 EP 10739 DI 10.1103/PhysRevB.52.10737 PG 3 WC Physics, Condensed Matter SC Physics GA TA852 UT WOS:A1995TA85200019 ER PT J AU SIZEMORE, DR BRANSTROM, AA SADOFF, JC AF SIZEMORE, DR BRANSTROM, AA SADOFF, JC TI ATTENUATED SHIGELLA AS A DNA DELIVERY VEHICLE FOR DNA-MEDIATED IMMUNIZATION SO SCIENCE LA English DT Article ID GRAM-NEGATIVE BACTERIA; ESCHERICHIA-COLI; FLEXNERI; CONSTRUCTION; SELECTION; PLASMID; VECTOR; CELLS; GENES AB Direct inoculation of DNA, in the form of purified bacterial plasmids that are unable to replicate in mammalian cells but are able to direct cell synthesis of foreign proteins, is being explored as an approach to vaccine development. Here, a highly attenuated Shigella vector invaded mammalian cells and delivered such plasmids into the cytoplasm of cells, and subsequent production of functional foreign protein was measured. Because this Shigella vector was designed to deliver DNA to colonic mucosa, the method is a potential basis for oral and other mucosal DNA immunization and gene therapy strategies. RP SIZEMORE, DR (reprint author), WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307, USA. NR 22 TC 223 Z9 238 U1 0 U2 4 PU AMER ASSOC ADVAN SCIENCE PI WASHINGTON PA 1333 H ST NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD OCT 13 PY 1995 VL 270 IS 5234 BP 299 EP 302 DI 10.1126/science.270.5234.299 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA RZ342 UT WOS:A1995RZ34200039 PM 7569980 ER PT J AU MARSHALL, KL JACOBS, SD MILLER, JE AF MARSHALL, KL JACOBS, SD MILLER, JE TI MIDINFRARED MODULATION THROUGH THE USE OF FIELD-INDUCED SCATTERING IN FERROELECTRIC LIQUID-CRYSTALS SO APPLIED OPTICS LA English DT Article ID TRANSIENT LIGHT-SCATTERING; DEPENDENCE AB The feasibility of the use of modulation devices based on field-induced transient scattering in ferroelectric liquid crystals (LC) to replace mechanical choppers used in uncooled infrared-imaging systems was investigated. Devices fabricated with ITO-coated ZnSe substrates and a ferroelectric LC path length of 25 mu m were able to modulate optical radiation by transient forward scattering at rates approaching 20 KHz, Through the use of a commercial arbitrary waveform generator and associated PC-based software, drive waveforms were developed that produced a variable, square-wave optical-modulation pattern by the extension of the duration of the scattering state to periods ranging from hundreds of microseconds to milliseconds. The ability of these extended-scattering-mode (ESM) devices to modulate radiation in both the visible and midinfrared regions was verified in a simple experiment through the use of a Fourier-transform infrared spectrometer, in which an unoptimized ESM device displayed a 40% modulation depth for IR radiation in the 8-12-mu m region. C1 USA,CECOM,NIGHT VIS & ELECTR SENSORS DIRECTORATE,FT BELVOIR,VA 22060. RP MARSHALL, KL (reprint author), UNIV ROCHESTER,COLL ENGN & APPL SCI,LASER ENERGET LAB,250 E RIVER RD,ROCHESTER,NY 14623, USA. NR 22 TC 4 Z9 4 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD OCT 10 PY 1995 VL 34 IS 29 BP 6704 EP 6713 PG 10 WC Optics SC Optics GA RX164 UT WOS:A1995RX16400010 PM 21060525 ER PT J AU CONLEY, JF LENAHAN, PM LELIS, AJ OLDHAM, TR AF CONLEY, JF LENAHAN, PM LELIS, AJ OLDHAM, TR TI ELECTRON-SPIN-RESONANCE EVIDENCE FOR THE STRUCTURE OF A SWITCHING OXIDE TRAP - LONG-TERM STRUCTURAL-CHANGE AT SILICON DANGLING BOND SITES IN SIO2 SO APPLIED PHYSICS LETTERS LA English DT Article ID SEMICONDUCTOR CAPACITORS; PARAMAGNETIC RESONANCE; POSITIVE CHARGE; INTERFACE; RADIATION; CENTERS; STATE AB We provide direct and unambiguous experimental spectroscopic evidence for the structure of a switching oxide trap in thermally grown SiO2 gate oxides on Si. Switching oxide traps can ''switch'' charge state in response to changes in the voltage applied to the gate of a metal-oxide-semiconductor field-effect transistor. Electron spin resonance measurements reveal that some E'(gamma) centers (a hole trapped at an oxygen vacancy) can behave as switching oxide traps. (C) 1995 American Institute of Physics. C1 USA,RES LAB,ADELPHI,MD 20783. RP CONLEY, JF (reprint author), PENN STATE UNIV,DEPT ENGN SCI & MECH,227 HAMMOND BLDG,UNIVERSITY PK,PA 16802, USA. NR 20 TC 34 Z9 34 U1 0 U2 4 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 9 PY 1995 VL 67 IS 15 BP 2179 EP 2181 DI 10.1063/1.115095 PG 3 WC Physics, Applied SC Physics GA RY398 UT WOS:A1995RY39800024 ER PT J AU STANLEY, AE BONICAMP, JM GODBEY, SE LUDWICK, LM AF STANLEY, AE BONICAMP, JM GODBEY, SE LUDWICK, LM TI LASER-INDUCED SELECTIVE NITRATION OF 3 CYCLOALKANES SO JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY LA English DT Article DE LASER; INFRARED; NITRATION; CYCLOALKANES ID RAMAN-SPECTRA AB Nitrated compounds are used as explosives and propellants. Laser-induced chemistry possesses the potential to drive some reactions in an efficient and selective manner, and may be useful in driving nitration reactions toward specific products. The results of several successful attempts to laser induce the reactions of nitrogen oxides with three cycloalkanes are reported. Specifically, the tunable, continuous-wave carbon dioxide infrared laser was used to drive the reaction between nitrogen dioxide and cyclopropane, cyclobutane and cyclopentane under a variety of reaction conditions. The optimization analysis of the reaction conditions is presented. In addition to the formation of nitrocycloalkanes, the other products formed were either from ring cleavage or from nitration or oxidation of ring fragments. By examining the impact of various reaction conditions on the product arrays, it was possible to find optimum conditions for producing the nitrocycloalkanes while minimizing side products. C1 MIDDLE TENNESSEE STATE UNIV,DEPT CHEM & PHYS,MURFREESBORO,TN 37132. EASTERN KENTUCKY UNIV,DEPT CHEM,RICHMOND,KY 40475. TUSKEGEE UNIV,TUSKEGEE,AL 36088. RP STANLEY, AE (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,AMSMI,WEAP SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. NR 14 TC 1 Z9 1 U1 0 U2 2 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 1010-6030 J9 J PHOTOCH PHOTOBIO A JI J. Photochem. Photobiol. A-Chem. PD OCT 4 PY 1995 VL 91 IS 1 BP 33 EP 52 DI 10.1016/1010-6030(95)04122-V PG 20 WC Chemistry, Physical SC Chemistry GA TC472 UT WOS:A1995TC47200006 ER PT J AU PATTERSON, A RYMARZ, P RAMAPRIAN, BR AF PATTERSON, A RYMARZ, P RAMAPRIAN, BR TI SURFACE PRESSURE MEASUREMENTS ON A PITCHING SWEPT WING IN A WATER CHANNEL SO AIAA JOURNAL LA English DT Article AB This paper presents the results of surface pressure measurements on a swept wing of NACA 0015 profile and a back sweep angle of 15 deg, which was pitched at a uniform angular velocity. The pitching axis was perpendicular to the how direction so that the experiment simulated the pitch-up maneuver of a fixed-wing aircraft. The experiments were performed in an open-surface water channel. The object of the study was to understand the mechanics of vorticity production and dynamic stall in three-dimensional unsteady flows. The phase-locked pressure data which were obtained at several closely spaced spanwise locations of the wing were used to obtain information on the fluxes of spanwise and chordwise vorticity components, in addition to the usual information on the aerodynamic coefficients. The study showed that the three-dimensional dynamic stall over the slightly swept wing is less catastrophic and more gradual than the two-dimensional process over an unswept wing. Other important effects observed were a spanwise variation of the aerodynamic coefficients and the presence of spanwise periodicity in the production of vorticity following the onset of dynamic stall. The experimental data have been archived and are available to any interested user. C1 WASHINGTON STATE UNIV,DEPT MECH & MAT ENGN,PULLMAN,WA 99164. RP PATTERSON, A (reprint author), USA,CORPS ENGINEERS,CTR HYDROELECT DIV,PORTLAND,OR 97208, USA. NR 18 TC 1 Z9 1 U1 0 U2 1 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0001-1452 J9 AIAA J JI AIAA J. PD OCT PY 1995 VL 33 IS 10 BP 1871 EP 1879 DI 10.2514/3.12740 PG 9 WC Engineering, Aerospace SC Engineering GA RY965 UT WOS:A1995RY96500016 ER PT J AU ELDRED, MS VENKAYYA, VB ANDERSON, WJ AF ELDRED, MS VENKAYYA, VB ANDERSON, WJ TI MODE TRACKING ISSUES IN STRUCTURAL OPTIMIZATION SO AIAA JOURNAL LA English DT Article ID EIGENVECTOR DERIVATIVES AB Within the context of optimization of the structural dynamics properties of finite element models, methodology is developed for the tracking of eigenpairs through changes in the structural eigenvalue problem. The goal is to eliminate difficulties caused by ''mode switching'' (i.e., frequency crossing), Out of several candidate methods, two methods for mode tracking are successful. The first method, the higher order eigenpair perturbation algorithm, is based on a perturbation expansion of the eigenproblem. It iteratively computes changes in the eigenpairs due to parameter perturbations with the important feature of maintaining the correspondence between the baseline and perturbed eigenpairs. The second method is a cross-orthogonality check method, which uses mass orthogonality to reestablish correspondence after a standard reanalysis. Modified eigenpair extraction routines (Lanezos, subspace iteration, inverse power) were unsuccessful in tracking modes. Applications of mode tracking technology that are presented are frequency-constrained optimization and optimization with mode shape constraints. Each application procedure is outlined and examples are given. Recommendations are made based on method efficiency and robustness in the example problems. C1 UNIV MICHIGAN,ANN ARBOR,MI 48109. USA,AEROFLIGHTDYNAM DIRECTORATE,WRIGHT PATTERSON AFB,OH 45433. NR 18 TC 26 Z9 26 U1 0 U2 1 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0001-1452 J9 AIAA J JI AIAA J. PD OCT PY 1995 VL 33 IS 10 BP 1926 EP 1933 DI 10.2514/3.12747 PG 8 WC Engineering, Aerospace SC Engineering GA RY965 UT WOS:A1995RY96500023 ER PT J AU FONTENOT, JD VANCOTT, TC PAREKH, BS PAU, CP GEORGE, JR BIRX, DL ZOLLAPAZNER, S GORNY, MK GATEWOOD, JM AF FONTENOT, JD VANCOTT, TC PAREKH, BS PAU, CP GEORGE, JR BIRX, DL ZOLLAPAZNER, S GORNY, MK GATEWOOD, JM TI PRESENTATION OF HIV V3 LOOP EPITOPES FOR ENHANCED ANTIGENICITY, IMMUNOGENICITY AND DIAGNOSTIC POTENTIAL SO AIDS LA English DT Article DE HUMAN MUCIN MUC1; HIV-1; V3 LOOP; TANDEM REPEATS; IMMUNOGENICITY; ANTIGENS; SURFACE PLASMON RESONANCE ID HUMAN MONOCLONAL-ANTIBODIES; IMMUNODEFICIENCY-VIRUS; ENVELOPE GLYCOPROTEIN; SYNTHETIC PEPTIDE; TYPE-1; MUCIN; GP120; PROTEIN; DOMAIN; IMMUNOASSAY AB Objective: To evaluate the immunological properties of a panel of human mucin MUC1/HIV V3 loop chimeras. Design: The immunodominant epitope of MUC1 (APDTR) was found to be structurally isomorphous with the tip of the principle neutralizing determinant (PND) of HIV-1 (MN) (GPGRA). A panel of 120 residue, six tandem repeat (TR) and 60 residue, three TR chimeric antigens were constructed in which the repeating MUC1 epitope is replaced by HIV-1 PND. Each 20 residue TR contains one PND epitope. The PND of HIV-1 is presented in the native beta-turn conformation at the crest of each repeating knob structure of the mucin-like protein. Methods: The antigenicity of the chimeric antigens were compared using enzyme-linked immunosorbent assay (ELISA) and HIV-infected patient sera. Structural effects of antibody-antigen interactions were determined using surface plasmon resonance, with human monoclonal antibodies, chimeric antigens and the cyclic and linear V3 loops. Immunogenicity of three versus six TR was measured in mice. Results: Nine residues of the HIV PND substituted into the mucin backbone were equivalent to the 36 residue cyclic V3 loop in ELISA. The 120 residue antigens induced high titer, immunoglobulin (Ig)M and Igc, and HIV-specific antibodies in mice. Conclusions: MUC1/V3 chimeras efficiently detect HIV-specific antibodies in patient sera. Multivalent presentation of the PND is advantageous for higher affinity antibody-antigen interactions and for inducing HIV-specific IgM and IgG antibodies. C1 LOS ALAMOS NATL LAB,DIV THEORET BIOL & BIOPHYS & LIFE SCI,LOS ALAMOS,NM. WALTER REED ARMY INST RES,DEPT RETROVIRAL RES,ROCKVILLE,MD. CTR DIS CONTROL & PREVENT,NATL CTR INFECT DIS,DIV HIV AIDS,ATLANTA,GA 30333. VET ADM MED CTR,NEW YORK,NY 10010. RP FONTENOT, JD (reprint author), POPULAT COUNCIL,1230 YORK AVE,NEW YORK,NY 10021, USA. FU NIAID NIH HHS [R01 AI32891-01A2] NR 44 TC 8 Z9 8 U1 1 U2 2 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0269-9370 J9 AIDS JI Aids PD OCT PY 1995 VL 9 IS 10 BP 1121 EP 1129 DI 10.1097/00002030-199510000-00002 PG 9 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA RW132 UT WOS:A1995RW13200002 PM 8519447 ER PT J AU ROVINSKI, B RODRIGUES, L CAO, SX YAO, FL MCGUINNESS, U SIA, C CATES, G ZOLLAPAZNER, S KARWOWSKA, S MATTHEWS, TJ MCDANAL, CB MASCOLA, J KLEIN, MH AF ROVINSKI, B RODRIGUES, L CAO, SX YAO, FL MCGUINNESS, U SIA, C CATES, G ZOLLAPAZNER, S KARWOWSKA, S MATTHEWS, TJ MCDANAL, CB MASCOLA, J KLEIN, MH TI INDUCTION OF HIV TYPE-1 NEUTRALIZING AND ENV-CD4 BLOCKING ANTIBODIES BY IMMUNIZATION WITH GENETICALLY-ENGINEERED HIV TYPE 1-LIKE PARTICLES CONTAINING UNPROCESSED GP160 GLYCOPROTEINS SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; HUMAN MONOCLONAL-ANTIBODIES; ENVELOPE GLYCOPROTEIN; HTLV-III/LAV; MUTATIONAL ANALYSIS; AIDS RETROVIRUS; GP120 BINDING; T4 MOLECULE; CLEAVAGE; SEQUENCE AB Genetically engineered, noninfectious HIV-1-like particles containing processed envelope glycoproteins represent potential candidate immunogens for a vaccine against HIV-1. However, since the gp120 glycoprotein is known to be rapidly lost from the surface of infected cells and purified virions as a result of its low-affinity interaction with gp41, shedding of this extracellular subunit could compromise the immunogenic potential of particle-based HIV-1 vaccine candidates. In this study, we demonstrate for the first time the feasibility of producing fully assembled HIV-1-like particles containing only unprocessed gp160 glycoproteins. Monkey kidney Vero cells were transfected with an inducible, human metallothionein-based expression vector containing most of the HIV-1(LAI) coding sequences that were genetically modified to introduce safety mutations and destroy the major cleavage site of the HIV-1 envelope glycoprotein. A stably-transfected cell line was isolated and shown to secrete HIV-1-like particles containing unprocessed gp160. Immunization with these particles induced HIV-1 cross-neutralizing, syncytium-inhibiting and env-CD4 blocking antibodies. Thus, these novel HIV-1-like particles represent alternative candidate immunogens for the development of a particle-based AIDS vaccine. C1 CONNAUGHT CTR BIOTECHNOL RES,DEPT IMMUNOL,N YORK,ON M2R 3T4,CANADA. CONNAUGHT CTR BIOTECHNOL RES,DEPT BACTERIOL,N YORK,ON M2R 3T4,CANADA. NYU,MED CTR,DEPT PATHOL,NEW YORK,NY 10016. DUKE UNIV,MED CTR,DEPT SURG,DURHAM,NC 27710. HENRY M JACKSON FDN,DIV RETROVIROL,ROCKVILLE,MD. WALTER REED ARMY INST RES,ROCKVILLE,MD 20850. CONNAUGHT CTR BIOTECHNOL RES,DEPT MOLEC GENET,N YORK,ON M2R 3T4,CANADA. RI Sia, Dwo-Yuan /E-3860-2010 FU NIAID NIH HHS [5-RO1-AI30411, AI72658, AI36085] NR 62 TC 17 Z9 18 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 1995 VL 11 IS 10 BP 1187 EP 1195 DI 10.1089/aid.1995.11.1187 PG 9 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA TD258 UT WOS:A1995TD25800007 PM 8573374 ER PT J AU VOGEL, FR ALVING, CR AF VOGEL, FR ALVING, CR TI ADJUVANTS AND NOVEL VACCINES - CONFERENCE SUMMARY SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Editorial Material C1 WALTER REED ARMY INST RES,DEPT MEMBRANE BIOCHEM,WASHINGTON,DC 20307. RP VOGEL, FR (reprint author), NIAID,DIV AIDS,VACCINE & PREVENT RES PROGRAM,SOLAR BLDG,ROM 2A28A,6003 EXECUT BLVD,ROCKVILLE,MD 20892, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 1995 VL 11 IS 10 BP 1277 EP 1278 DI 10.1089/aid.1995.11.1277 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA TD258 UT WOS:A1995TD25800021 ER PT J AU ROBB, M BRIDGES, S MMIRO, F FOWLER, MG FAST, P MCNAMARA, J AF ROBB, M BRIDGES, S MMIRO, F FOWLER, MG FAST, P MCNAMARA, J TI REPORT OF THE PREVENTION OF PERINATAL HIV TYPE-1 TRANSMISSION WORKSHOP - CONFERENCE SUMMARY SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Editorial Material C1 NIAID,DIV AIDS,BETHESDA,MD 20892. MAKERERE UNIV,DEPT OBSTET & GYNECOL,KAMPALA,UGANDA. RP ROBB, M (reprint author), WALTER REED ARMY INST RES,DIV RETROVIROL,13 TAFT COURT,SUITE 200,ROCKVILLE,MD 20850, USA. NR 9 TC 3 Z9 3 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 1995 VL 11 IS 10 BP 1301 EP 1303 DI 10.1089/aid.1995.11.1301 PG 3 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA TD258 UT WOS:A1995TD25800026 ER PT J AU CARVALHO, RM YOSHIYAMA, M HORNER, JA PASHLEY, DH AF CARVALHO, RM YOSHIYAMA, M HORNER, JA PASHLEY, DH TI BONDING MECHANISM OF VARIGLASS TO DENTIN SO AMERICAN JOURNAL OF DENTISTRY LA English DT Article ID ADHESION AB Purpose: This study investigated the hypothesis that the new resin-reinforced, light-cued glass ionomer cement (GIG) can develop mechanical retention by forming a hybrid layer in acid-etched dentin. Materials and Methods: Dentin discs were obtained from extracted human third molars and sanded with 320 SiC abrasive paper. One third of the surface was acid etched with 10% maleic acid for 15 seconds, washed and gently air-dried for 5 seconds. ProBond primer from the VariGlass (VG) GIC kit was applied onto the acid-etched surface (A) and another third of the unetched surface (B) for 30 seconds. One third of the surface was not treated (C). VG GIC was then applied onto the entire surface of the disc. After 24 hours the discs were fractured along their diameters. One half of the fractured disc was highly polished at the interface and treated with 6N HCl for 30 seconds while the other half of the fractured specimen was left untreated. Both halves were viewed by SEM. In another part of the study, a micro-tensile bond strength (MTBS) test was carried out to compare the acid-etched group vs. the nonetched group. Results: SEM pictures revealed a well defined demineralized, resin-infiltrated zone approximately 3 mu m in thickness for group (A) for both fractured and polished surface. Dentin surfaces that only received primer (B) showed an irregular zone 0.5-1.5 mu m thick. Such a resin-infiltrated layer was resistant to HCl treatment. A gap was observed between the GIC and dentin in group (C). polished interfaces appeared to be highly infiltrated. However, fractured interfaces revealed considerable porosity within the demineralized-infiltrated zone. MTBS results were (x +/- SD, MPa): 28.9 +/- 5.8 for the etched group and 24.5 +/- 4.9 for the nonetched group. This difference was statistically significant. C1 UNIV TOKUSHIMA,TOKUSHIMA 770,JAPAN. DWIGHT EISENHOWER MED CTR,DEPT CLIN & LAB INVEST,FT GORDON,GA. MED COLL GEORGIA,SCH DENT,AUGUSTA,GA 30912. RP CARVALHO, RM (reprint author), UNIV SAO PAULO,BAURU SCH DENT,FOB,DEPT DENT,CP 73,BR-17043101 BAURU,SP,BRAZIL. FU NIDCR NIH HHS [DE06427] NR 16 TC 25 Z9 27 U1 0 U2 0 PU MOSHER & LINDER, INC PI SAN ANTONIO PA 9859 IH-10 WEST, SUITE 107/489, SAN ANTONIO, TX 78230-2236 SN 0894-8275 J9 AM J DENT JI Am. J. Dent. PD OCT PY 1995 VL 8 IS 5 BP 253 EP 258 PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA TC496 UT WOS:A1995TC49600007 PM 8634162 ER PT J AU MCCALMONT, TH ALTEMUS, D MAURER, T BERGER, TG AF MCCALMONT, TH ALTEMUS, D MAURER, T BERGER, TG TI EOSINOPHILIC FOLLICULITIS - THE HISTOLOGIC SPECTRUM SO AMERICAN JOURNAL OF DERMATOPATHOLOGY LA English DT Article DE EOSINOPHILIC FOLLICULITIS; HUMAN IMMUNODEFICIENCY VIRUS; PRURITUS; ACQUIRED IMMUNODEFICIENCY SYNDROME; PAPULAR ERUPTION ID HUMAN-IMMUNODEFICIENCY-VIRUS; PUSTULAR FOLLICULITIS; PAPULAR ERUPTION; INFECTION; DERMATITIS; DERMATOSIS; INTERFACE; DISEASE; SKIN; AIDS AB We sought to define the light microscopic features of eosinophilic folliculitis as it occurs in human immunodeficiency virus (HIV)-infected individuals. The histologic findings of 52 biopsies from 50 patients were graded and compared with six biopsies of suppurative folliculitis from HIV-infected individuals. In all patients, clinical examination showed an eruption of pruritic follicular papules, and the folliculocentric nature of the disorder was confirmed histologically. Perifollicular infiltrates of lymphocytes and eosinophils were identified in all study biopsies, and there was also spongiosis of follicular epithelium. The inflammatory reaction was focused at the level of the follicular isthmus and the sebaceous duct. In all biopsies, lymphocytes and/or eosinophils were present within spongiotic follicular epithelium, but intrafollicular neutrophils were rare. Sebaceous glandular inflammation, eosinophilic pustule formation, and follicular rupture were present in less than half of the biopsies. Small numbers of microbes (bacteria, yeast, Demodex) were identified in 25% of the study biopsies in routine or special stains, but the organisms were away from areas of inflammation and were interpreted as nonpathogenic flora. The biopsies of suppurative folliculitis differed in that neutrophils and macrophages predominated in the infiltrate, microorganisms were readily identified in the inflammatory reaction, and the involved follicle was often ruptured. We believe that eosinophilic folliculitis is a unique HIV-associated dermatosis distinguishable from other folliculitides and papular dermatitides by clinical examination and light microscopy. We present our diagnostic approach. C1 UNIV CALIF SAN FRANCISCO,MED CTR,DEPT DERMATOL,SAN FRANCISCO,CA 94143. BROOKE ARMY MED CTR,DEPT DERMATOL,FT SAM HOUSTON,TX 78234. RP MCCALMONT, TH (reprint author), UNIV CALIF SAN FRANCISCO,MED CTR,DEPT PATHOL,SAN FRANCISCO,CA 94143, USA. NR 22 TC 36 Z9 36 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0193-1091 J9 AM J DERMATOPATH JI Am. J. Dermatopathol. PD OCT PY 1995 VL 17 IS 5 BP 439 EP 446 DI 10.1097/00000372-199510000-00002 PG 8 WC Dermatology SC Dermatology GA TB955 UT WOS:A1995TB95500002 PM 8599447 ER PT J AU KADAKIA, SC KIKENDALL, JW MAYDONOVITCH, C JOHNSON, LF AF KADAKIA, SC KIKENDALL, JW MAYDONOVITCH, C JOHNSON, LF TI EFFECT OF CIGARETTE-SMOKING ON GASTROESOPHAGEAL REFLUX MEASURED BY 24-H AMBULATORY ESOPHAGEAL PH MONITORING SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article ID ACID REFLUX; NICOTINE ADDICTION; DISEASE; MECHANISMS; SPHINCTER; CLEARANCE; PATTERNS; THERAPY; METRY AB Objective: We reassessed the effect of cigarette smoking on gastroesophageal reflux because two previous ambulatory 24-h pH monitoring studies showed equivocal results and did not relate heartburn to changes in pH reflux events, Methods: Our protocol design considered nicotine's pharmacokinetic half-life; 14 smokers with heartburn and esophagitis abstained from smoking for 48 h before and during an ambulatory 24-h esophageal pH monitoring study (24-h pH), After resuming their smoking habits for 48 h or more, they underwent a second 24-h pH study and smoked 20 regular, filtered Marlboro cigarettes, Acid reflux was defined as a drop in intraesophageal pH to a value < 4 at 5 cm above the lower esophageal sphincter and was measured as percent exposure and reflux events (total N, those greater than or equal to 5 min, and longest event), Heartburn episodes were noted by the patients and were correlated later to acid reflux events, Results: Cigarette smoking significantly increased the percentage time that the pH was < 4 during a 24-h period from 7.35 to 11.1% (medians; p < 0.007), This increased exposure occurred predominantly during the day while in the upright posture and resulted from significant increases in both reflux events and those parameters that measure acid clearance (T events greater than or equal to 5 min and longest event), While smoking, the patients noted a 114% increase in daytime heartburn episodes that immediately followed a pH reflux event (3.5 to 7.5 episodes, medians; p < 0.009). Conclusions: Smoking 20 cigarettes has a greater effect on acid reflux and heartburn than purported. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MED,DIV DIGEST DIS,BETHESDA,MD. BROOKE ARMY MED CTR,GASTROENTEROL SERV,SAN ANTONIO,TX. BROOKE ARMY MED CTR,DEPT MED,SAN ANTONIO,TX. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 34 TC 48 Z9 51 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 1995 VL 90 IS 10 BP 1785 EP 1790 PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA RY259 UT WOS:A1995RY25900012 PM 7572895 ER PT J AU HUME, RF PUDER, K SHIELS, WE MACRI, C JOHNSON, MP EVANS, MI AF HUME, RF PUDER, K SHIELS, WE MACRI, C JOHNSON, MP EVANS, MI TI TURKEY-BREASTS - A PRACTICAL MODEL FOR IN-VITRO AMNIOCENTESIS TRAINING SO AMERICAN JOURNAL OF HUMAN GENETICS LA English DT Meeting Abstract C1 WAYNE STATE UNIV,HUTZEL HOSP,CTR FETAL DIAG & THERAPY,DETROIT,MI. MADIGAN ARMY MED CTR,TACOMA,WA. WALTER REED ARMY MED CTR,WASHINGTON,DC. NR 0 TC 0 Z9 0 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0002-9297 J9 AM J HUM GENET JI Am. J. Hum. Genet. PD OCT PY 1995 VL 57 IS 4 SU S BP 1635 EP 1635 PG 1 WC Genetics & Heredity SC Genetics & Heredity GA RW687 UT WOS:A1995RW68701632 ER PT J AU HIGBY, K SUITER, CR SILERKHODR, T AF HIGBY, K SUITER, CR SILERKHODR, T TI A COMPARISON BETWEEN 2 SCREENING METHODS FOR DETECTION OF MICROPROTEINURIA SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article; Proceedings Paper CT 15th Annual Meeting of the Society-of-Perinatal-Obstetricians CY JAN 23-28, 1995 CL ATLANTA, GA SP Soc Perinatal Obstetricians DE PROTEINURIA; MICROALBUMINURIA; MULTISTIX 10SG; MICRO-BUMINTEST ID MICROALBUMINURIA; PREGNANCY AB OBJECTIVE: We compared two screening tests for microproteinuria with 24-hour quantitative measurements to determine which method is better at predicting clinically significant proteinuria. STUDY DESIGN: We obtained 690 24-hour urine collections from both low- and high-risk patients seen for prenatal care. Qualitative screening for microproteinuria on the basis of the protein-error-of-indicators principle (Ames Multistix 10SG and Micro-bumintest, Miles Diagnostic Division, Elkhart, Ind.) was done by the same investigator (C.S.). Quantitative assay was done by use of pyrogallol red-molybdate for total protein and by radioimmunoassay for albumin. RESULTS: The Micro-bumintest had a sensitivity of 87% compared with 36% for the Multistix 10SG. It also had a higher specificity and higher positive and negative predictive values. The Micro-bumintest was a better screening test in patients with significant protein excretion (> 300 mg/24 hours). CONCLUSION: The Micro-bumintest has a much higher sensitivity and a lower false-negative rate than does the Multistix 10SG. Our data support the Micro-bumintest as a better screening test for clinically significant proteinuria. C1 UNIV TEXAS,HLTH SCI CTR,DEPT OBSTET & GYNECOL,SAN ANTONIO,TX 78284. RP HIGBY, K (reprint author), BROOKE ARMY MED CTR,DEPT OBSTET & GYNECOL,FT SAM HOUSTON,TX 78234, USA. NR 12 TC 12 Z9 12 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD OCT PY 1995 VL 173 IS 4 BP 1111 EP 1114 DI 10.1016/0002-9378(95)91335-1 PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA TC502 UT WOS:A1995TC50200018 PM 7485302 ER PT J AU STOUT, SD LUECK, R AF STOUT, SD LUECK, R TI BONE REMODELING RATES AND SKELETAL MATURATION IN 3 ARCHAEOLOGICAL SKELETAL POPULATIONS SO AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY LA English DT Article DE CORTICAL BONE; HISTOMORPHOMETRY; REMODELING; EFFECTIVE AGE OF ADULT COMPACTA ID CORTICAL BONE; AGE; DEATH; AGRICULTURE; FEMUR AB Cortical bone remodeling rates for rib samples from three archaeological populations and a modern autopsy sample were determined using an algorithm developed by Frost (Frost [1987a] Calcif. Tissue Res. 3:211-237). When plotted against the relative antiquities for population samples, histomorphometric variables; i.e., activation frequency (<(mu)over bar>(rc)), net bone formation (V-net(f,r,t)), and mean annual bone formation rate (V-f,V-r,V-t), exhibit a concordant trend of increased cortical bone remodeling activity levels over time. Two intensive foraging populations, Windover and Gibson, are similar for all bone remodeling parameters and have the lowest remodeling activity levels among the samples. The more recent Ledders sample, which is reported to practice agricultural subsistence, is consistently intermediate between these and a modern autopsy sample. Although there appear to be differences in bone formation rates among the populations, it is concluded that these differences cannot be attributed to differences in bone remodeling rates among the populations, but rather are reflecting different effective ages of adult compacta for their ribs. These findings suggest that the earlier populations, particularly Windsor and Gibson, appear to have reached skeletal maturity at an older age than observed for modern. (C) 1995 Wiley-Liss, Inc. C1 USA,CORPS ENGINEERS,ST LOUIS,MO 63103. RP STOUT, SD (reprint author), UNIV MISSOURI,DEPT ANTHROPOL,200 SWALLOW HALL,COLUMBIA,MO 65211, USA. NR 27 TC 36 Z9 36 U1 1 U2 7 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0002-9483 J9 AM J PHYS ANTHROPOL JI Am. J. Phys. Anthropol. PD OCT PY 1995 VL 98 IS 2 BP 161 EP 171 DI 10.1002/ajpa.1330980206 PG 11 WC Anthropology; Evolutionary Biology SC Anthropology; Evolutionary Biology GA RX842 UT WOS:A1995RX84200005 PM 8644877 ER PT J AU COLBECK, SC AF COLBECK, SC TI PRESSURE MELTING AND ICE SKATING SO AMERICAN JOURNAL OF PHYSICS LA English DT Article AB Pressure melting cannot be responsible for the low friction of ice. The pressure needed to reach the melting temperature is above the compressive failure stress and, if it did occur, high squeeze losses would result in very thin films. Pure liquid water cannot coexist with ice much below -20 degrees C at any pressure and friction does not increase suddenly in that range. If frictional heating and pressure melting contribute equally, the length of the wetted contact could not exceed 15 mu m at a speed of 5 m/s, which seems much too short. If pressure melting is the dominant process, the water films are less than 0.08 mu m thick because of the high pressures. RP COLBECK, SC (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 9 TC 23 Z9 23 U1 1 U2 14 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0002-9505 J9 AM J PHYS JI Am. J. Phys. PD OCT PY 1995 VL 63 IS 10 BP 888 EP 890 DI 10.1119/1.18028 PG 3 WC Education, Scientific Disciplines; Physics, Multidisciplinary SC Education & Educational Research; Physics GA RW121 UT WOS:A1995RW12100015 ER PT J AU MANGUIN, S ROBERTS, DR PEYTON, EL FERNANDEZSALAS, I BARRETO, M LOAYZA, RF SPINOLA, RE GRANAOU, RM RODRIGUEZ, MH AF MANGUIN, S ROBERTS, DR PEYTON, EL FERNANDEZSALAS, I BARRETO, M LOAYZA, RF SPINOLA, RE GRANAOU, RM RODRIGUEZ, MH TI BIOCHEMICAL SYSTEMATICS AND POPULATION GENETIC-STRUCTURE OF ANOPHELES PSEUDOPUNCTIPENNIS, VECTOR OF MALARIA IN CENTRAL AND SOUTH-AMERICA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID STARCH-GEL ELECTROPHORESIS; DISTANCE AB An electrophoretic survey of 42 populations of Anopheles pseudopunctipennis collected throughout its known geographic distribution was performed to clarify the taxonomic status of this important malaria vector species. The results indicated strong differences in the allele frequencies of three enzyme loci (glycerol dehydrogenase, 6-phosphogluconate dehydrogenase, and phosphoglucomutase) of the 33 loci analyzed. No fixed electromorphic differences separate the populations of An. pseudopuntipennis. The populations of An. pseudopunctipennis showed little genetic divergence, with Nei distances ranging from 0 to 0.079. A comparison of An. pseudopunctipennis data with either one of three other Anopheles species showed a high genetic distance of 0.335 with a closely related species, An, franciscanus; 0.997 with An. crucians, and 2.355 with An, (Nyssorhynchus) albimanus. Geographic populations of An. pseudopunctipennis were classified into three clusters; one cluster included populations collected in North America (United States and Mexico) and Guatemala, one cluster included populations from Belize and South America (Colombia, Ecuador, Peru, Chile, and Argentina); and one cluster was represented by populations from the Island of Grenada (type-locality of An. pseudopunctipennis). Based on our isozyme analyses, we defined these clusters as three geographic populations of An. pseudopunctipennis. Of the two mainland populations, one extends from the southern United States south through Mexico and Guatemala, and the other extends north from southern South America through Central America to Belize. These two geographic populations converge in southern Mexico and northern Central America. One part of the convergence zone was identified in the area of eastern Guatemala and southern Belize. C1 UNIFORMED SERV UNIV HLTH SCI, DEPT PREVENT MED & BIOMETR, BETHESDA, MD USA. WALTER REED ARMY INST RES, DEPT ENTOMOL, WALTER REED BIOSYSTEMAT UNIT, WASHINGTON, DC USA. UNIV AUTONOMA NEUVO LEON, FAC CIENCIAS BIOL, ENTOMOL MED LAB, SAN NICOLAS DE GARZAS, NUEVO LEON, MEXICO. UNIV VALLE, CALI, COLOMBIA. NAVAL MED RES INST DETACHMENT, LIMA, PERU. UNIV SAN CARLOS, FAC CIENCIAS QUIM & FARM, GUATEMALA CITY, GUATEMALA. SERV SALUD ARICA, ARICA, CHILE. CTR INVEST PALUDISMO, TAPACHULA, CHIAPAS, MEXICO. RI Manguin, Sylvie/G-1787-2015 OI Manguin, Sylvie/0000-0002-5925-7164 NR 36 TC 40 Z9 42 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1995 VL 53 IS 4 BP 362 EP 377 PG 16 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA TD727 UT WOS:A1995TD72700008 PM 7485688 ER PT J AU MULLER, R SALUZZO, JF LOPEZ, N DREIER, T TURELL, M SMITH, J BOULOY, M AF MULLER, R SALUZZO, JF LOPEZ, N DREIER, T TURELL, M SMITH, J BOULOY, M TI CHARACTERIZATION OF CLONE-13, A NATURALLY ATTENUATED AVIRULENT ISOLATE OF RIFT-VALLEY FEVER VIRUS, WHICH IS ALTERED IN THE SMALL SEGMENT SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID INFECTED-CELLS; CULEX-PIPIENS; MONOCLONAL-ANTIBODIES; ANTIGENIC ANALYSIS; SANDFLY FEVER; PUNTA-TORO; BUNYAVIRIDAE; EGYPT; IDENTIFICATION; REPLICATION AB The 74HB59 strain of Rift Valley fever (RVF) virus, isolated from a human case in the Central African Republic, was shown to be composed of a heterogeneous population of viruses when plaque-purified clones were analyzed for their reactivity with monoclonal antibodies (MAbs) directed against the nucleocapsid (N) protein or the nonstructural (NSs) protein. One of these clones, C13, was of particular interest in that it proved to be avirulent in mice and hamsters, and highly immunogenic. Although C13 showed normal reactivity with a large panel of MAbs directed at the glycoproteins, it failed to react with specific MAbs or polyclonal antibodies directed at the NSs protein and with a specific MAb recognizing the N protein of the Egyptian strains. Consequently, the small RNA segment, which encodes the N and NSs proteins in an ambisense strategy, was sequenced and compared with the existing sequence of the attenuated MP-12 RVF virus strain. We found that the NSs gene contained, in addition to two conservative coding changes, a large internal deletion of 549 nucleotides that removes 69% of the open reading frame but conserves in-frame the N and C termini of the predicted translation product. In addition, the sequence revealed that the N protein of C13 contained a single amino acid change. Clone C13 replicated normally in certain cell types in vitro and in Culex pipiens mosquitoes after intrathoracic inoculation, but established abortive infections in MRC-5 human fibroblasts. C1 PASTEUR MERIEUX SERUMS & VACCINS,MARCY LETOILE,FRANCE. USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702. RP MULLER, R (reprint author), INST PASTEUR,BUNYAVIRIDES LAB,25 RUE DR ROUX,F-75724 PARIS,FRANCE. NR 33 TC 149 Z9 150 U1 1 U2 7 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1995 VL 53 IS 4 BP 405 EP 411 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA TD727 UT WOS:A1995TD72700015 PM 7485695 ER PT J AU SMUCNY, JJ KELLY, EP MACARTHY, PO KING, AD AF SMUCNY, JJ KELLY, EP MACARTHY, PO KING, AD TI MURINE IMMUNOGLOBULIN-G SUBCLASS RESPONSES FOLLOWING IMMUNIZATION WITH LIVE DENGUE VIRUS OR A RECOMBINANT DENGUE ENVELOPE PROTEIN SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ANTIBODY; MICE; ANTIGENS; ENCEPHALITIS; RESTRICTION; PROTECTION; MECHANISMS; INFECTION; ISOTYPE; SERUM AB Murine immunoglobulin G (IgG) subclass responses to immunization are restricted to certain subclasses depending on the nature of the immunogen. Immunization with live viruses generally leads to a predominant IgG2a response, which may be the most effective at resisting future challenge due to the unique effector functions of IgG2a. Knowledge of subclass responses following immunization with dengue vaccine candidates may be helpful in determining which candidates are most efficacious. We measured the dengue-specific IgG subclass responses of BALB/c mice following immunization with live dengue-2 virus or with a partially purified recombinant dengue-2 envelope (E) protein. Subclass responses following immunization with live virus were IgG2a > IgG1 > IgG2b > IgG3, as opposed to IgG1 > IgG2a > IgG2b > IgG3 after immunization with recombinant protein. Responses of all subclasses except IgG1 were greater following immunization with live dengue than with the recombinant E protein. Neutralizing antibody titers were also higher after immunization with live virus than with E protein and were positively correlated with dengue-specific IgG2a responses in mice immunized with recombinant E protein. Following separation of the four IgG subclasses by chromatography, the IgG2a fraction exhibited the greatest neutralizing activity. The results seen after immunization with live dengue virus or recombinant E protein in this study are in concordance with studies involving other viruses and viral proteins and may have implications for the development of an effective vaccine for dengue. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT VIRUS DIS,WASHINGTON,DC 20307. RP SMUCNY, JJ (reprint author), WOMACK ARMY MED CTR,DEPT FAMILY MED,FT BRAGG,NC 28377, USA. NR 26 TC 24 Z9 26 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1995 VL 53 IS 4 BP 432 EP 437 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA TD727 UT WOS:A1995TD72700019 PM 7485699 ER PT J AU KUZMA, PJ KLINE, MD STAMATOS, JM AUTH, DA AF KUZMA, PJ KLINE, MD STAMATOS, JM AUTH, DA TI ACUTE TOXIC DELIRIUM - AN UNCOMMON REACTION TO TRANSDERMAL FENTANYL SO ANESTHESIOLOGY LA English DT Note DE ANALGESICS, TRANSDERMAL, FENTANYL; COMPLICATIONS, DELIRIUM; PAIN, CHRONIC, CANCER AB TRANSDERMAL fentanyl (Duragesic, Janssen, Titusville, NJ) is indicated in the management of chronic pain in opioid-tolerant patients requiring opioid analgesia and is used in the treatment of cancer pain. We present a case of acute toxic delirium in a patient being treated with transdermal fentanyl. C1 WALTER REED ARMY MED CTR,ANESTHESIA & OPERAT SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,ANESTHESIA PAIN SERV,WASHINGTON,DC 20307. ST VINCENTS HOSP & MED CTR,NEW YORK,NY 10011. WALTER REED ARMY MED CTR,SERV PHARM,WASHINGTON,DC 20307. NR 7 TC 9 Z9 9 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD OCT PY 1995 VL 83 IS 4 BP 869 EP 871 PG 3 WC Anesthesiology SC Anesthesiology GA RY955 UT WOS:A1995RY95500032 PM 7574070 ER PT J AU GREILICH, PE GREILICH, NB FROELICH, EG AF GREILICH, PE GREILICH, NB FROELICH, EG TI INTRAABDOMINAL FIRE DURING LAPAROSCOPIC CHOLECYSTECTOMY SO ANESTHESIOLOGY LA English DT Note DE COMPLICATIONS, CARBON DIOXIDE TANKS, FIRE, LAPAROSCOPIC SURGERY AB LAPAROSCOPIC surgery for elective cholecystectomy has undergone rapid acceptance since it initially was described in 1988.(1-3) Complications unique to laparoscopic surgery result mainly from the cardiopulmonary impact of creating a pneumoperitoneum and choice of insufflating gas.(4-6) Overall morbidity rates of 2-5% for laparoscopic cholecystectomy compare favorably to the 4-8% documented with open procedures.(7-9) We report a case of intraabdominal fire secondary to insufflating the incorrect concentration of carbon dioxide gas during a laparoscopic cholecystectomy. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 15 TC 13 Z9 13 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD OCT PY 1995 VL 83 IS 4 BP 871 EP 874 DI 10.1097/00000542-199510000-00031 PG 4 WC Anesthesiology SC Anesthesiology GA RY955 UT WOS:A1995RY95500033 PM 7574071 ER PT J AU CRAIG, TJ HERSHEY, J ENGLER, RJM CARPENTER, G SMITH, L SALATA, K AF CRAIG, TJ HERSHEY, J ENGLER, RJM CARPENTER, G SMITH, L SALATA, K TI TANNIC ACIDS EFFECT ON BIRD ANTIGEN SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY LA English DT Article ID FANCIERS LUNG; PNEUMONIA; REMOVAL AB Background: Birds have been associated with many diseases including hypersensitivity pneumonitis and allergic diseases such as asthma and rhinitis. Bird antigen from homes of patients with hypersensitivity pneumonitis persists long after the bird is removed from the home. This may account for the persistence of symptoms, signs, and bird-specific IgG in patients with hypersensitivity pneumonitis. Tannic acid application has been effective in decreasing cat and mite allergen levels. No data have been available on tannic acid's effect on bird antigen. Objective: It is the purpose of this study to determine whether tannic acid reduces bird antigen in the home. Method: Dust samples were collected from homes with bird antigen before and after application of tannic acid. Samples were assayed for bird antigen levels using a competitive inhibition ELISA. Pre- and post-bird antigen levels were compared using a paired t test to determine whether antigen was reduced significantly. Results: There was not a statistical difference between bird antigen levels before and after application of tannic acid as compared by paired t test (P = .09). Conclusion: Tannic acid is not effective in decreasing bird antigen levels. In patients with hypersensitivity pneumonitis or allergic disease to birds, the bird should be removed from the home and environmental cleanup should be undertaken, but tannic acid application is not indicated. C1 WALTER REED ARMY MED CTR,DEPT INTERNAL MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIV ALLERGY IMMUNOL,WASHINGTON,DC 20307. NR 14 TC 1 Z9 1 U1 0 U2 0 PU AMER COLL ALLERGY ASTHMA IMMUNOLOGY PI ARLINGTON HTS PA 85 WEST ALGONQUIN RD SUITE 550, ARLINGTON HTS, IL 60005 SN 1081-1206 J9 ANN ALLERG ASTHMA IM JI Ann. Allergy Asthma Immunol. PD OCT PY 1995 VL 75 IS 4 BP 348 EP 350 PG 3 WC Allergy; Immunology SC Allergy; Immunology GA TA736 UT WOS:A1995TA73600011 PM 7583852 ER PT J AU POWERS, EM AF POWERS, EM TI EFFICACY OF THE RYU NONSTAINING KOH TECHNIQUE FOR RAPIDLY DETERMINING GRAM REACTIONS OF FOOD-BORNE AND WATERBORNE BACTERIA AND YEASTS SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Note AB A simple and rapid (< 60 s) nonstaining technique with 3% potassium hydroxide to determine Gram reactions was tested with 495 food-borne and waterborne bacteria and yeasts. In KOH, suspensions of gram-negative bacteria become viscous and string out. Gram-positive bacteria are not affected. There was 100% correlation between the KOH string test results and gram-positive and gram-negative strains. RP POWERS, EM (reprint author), USA,SOLDIER SYST COMMAND,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 19 TC 222 Z9 225 U1 1 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD OCT PY 1995 VL 61 IS 10 BP 3756 EP 3758 PG 3 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA RY071 UT WOS:A1995RY07100042 PM 7487012 ER PT J AU WEESE, CB KRAUSS, MR AF WEESE, CB KRAUSS, MR TI A BARRIER-FREE HEALTH-CARE SYSTEM DOES NOT ENSURE ADEQUATE VACCINATION OF 2-YEAR-OLD CHILDREN SO ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE LA English DT Article ID MISSED OPPORTUNITIES; IMMUNIZATION; MEASLES AB Objectives: To assess vaccination status in a cohort of 2 year olds with access to health care at no cost and to delineate factors associated with failure To be fully vaccinated. Design: Retrospective cross-sectional study. Children not up-to-date on vaccinations by age 2 years compared with children up-to-date by medical record review. A telephone survey was conducted for those without medical records or whose records lacked complete documentation. Setting: Large military tertiary care hospital. Participants: A cohort of 844 children born between August 31, 1988, and September 1, 1989. Main Outcome Measures: Timeliness of vaccination, factors associated with under vaccination, number and nature of missed opportunities, Results: Best estimate of coverage with entire primary vaccination series was 72% by age 2 years. Attendance at military day care was associated with full vaccination (odds ratio [OR]=1.80, confidence interval [CI]=1.12 to 3.24) as was completion of well-baby visits. Increasing number of other visits did not predict full vaccination. Children followed up by family practice were more likely to be up-to-date than children followed up by pediatrics (OR=3.67, CI=1.47 to 9.73). Seventy-two percent of children who were not up-to-date had at least one missed opportunity for vaccination. If vaccinations had been offered at all visits, 93% of children could have been fully vaccinated by age 2 years. Conclusions: Offering free vaccinations in a ''barrier-free'' system will not ensure vaccination levels of 90%. Health care providers should offer vaccinations during acute, non-well visits to improve coverage. C1 USA,MED CTR,PREVENT MED SERV,TACOMA,WA. NR 18 TC 18 Z9 18 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 1072-4710 J9 ARCH PEDIAT ADOL MED JI Arch. Pediatr. Adolesc. Med. PD OCT PY 1995 VL 149 IS 10 BP 1130 EP 1135 PG 6 WC Pediatrics SC Pediatrics GA RY980 UT WOS:A1995RY98000012 PM 7550817 ER PT J AU CALDWELL, JA CALDWELL, JL CROWLEY, JS JONES, HD AF CALDWELL, JA CALDWELL, JL CROWLEY, JS JONES, HD TI SUSTAINING HELICOPTER PILOT PERFORMANCE WITH DEXEDRINE(R) DURING PERIODS OF SLEEP-DEPRIVATION SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article AB Background: Around-the-clock operations often are mandated in combat, but while aircraft can function effectively throughout continuous 24-hour periods, aviators often cannot because of sleep loss. An efficacious countermeasure in sustained operations may be the administration of dextroamphetamine (Dexedrine(R)). Hypothesis: Dexedrine(R) will effectively prevent many of the performance problems associated with sleep deprivation in helicopter pilots. Methods: A placebo-controlled, double blind study was conducted. Six U.S. Army helicopter pilots completed five flights in a UH-60 simulator while their performance was evaluated. Immediately following each flight, data were collected on electroencephalographic (EEG) activity and subjective mood ratings. Testing sessions occurred at 0100, 0500, 0900, 1300, and 7700. One hour prior to each of the first three flights on drug-administration days, the aviators were given 10 mg of Dexedrine(R) or placebo. Results:Dexedrine(R), in comparison to placebo, improved aviator simulator control on descents, straight-and-levels, standard-rate turns, and a leftaescending turn. Performance was facilitated most noticeably at 0500, 0900, and 1700 (after 22, 26, and 34 hours of continuous wakefulness). EEC and mood data showed that alertness was sustained significantly by Dexedrine(R)-there was reduced slow-wave EEG activity and improved ratings of vigor and fatigue. No adverse behavioral or physiological effects were observed. Conclusions: Dexedrine(R) appears to be effective for sustaining helicopter pilot performance during short periods of sleep loss without producing adverse side effects. RP CALDWELL, JA (reprint author), USA,ARL,DIV AIRCREW HLTH & PERFORMANCE,FT RUCKER,AL 36362, USA. NR 15 TC 29 Z9 32 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD OCT PY 1995 VL 66 IS 10 BP 930 EP 937 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA RX866 UT WOS:A1995RX86600002 PM 8526828 ER PT J AU LYONS, TP MUZA, SR ROCK, PB CYMERMAN, A AF LYONS, TP MUZA, SR ROCK, PB CYMERMAN, A TI THE EFFECT OF ALTITUDE PRE-ACCLIMATIZATION ON ACUTE MOUNTAIN-SICKNESS DURING REEXPOSURE SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID DEXAMETHASONE; PROPHYLAXIS AB Background: Acclimatization to high altitude appears to prevent acute mountain sickness (AMS), as evidenced by a decline in AMS symptoms as acclimatization progresses. Hypothesis: We hypothesized that partial retention of acclimatization would attenuate the incidence and/or severity of AMS upon reinduction to altitude. Methods: To test this hypothesis 6 male lowlanders returned to sea level after acclimatizing for 16 d at 4300 m (HA). After 8 d at sea level (PA), they were reexposed to 4300 m in a hypobaric chamber for 30 h (RA). AMS symptom severity was determined by the AMS-cerebral (AMS-C) scores calculated from the daily administration of the Environmental Symptoms Questionnaire during HA and RA. Results: The mean AMS-C scores were reduced from 0.6 on HA day 1 (HA1) to 0.1 during RA (p < 0.05). Four subjects were ''sick'' (AMS-C > 0.7) during HA1, while only one was ''sick'' during RA. The % oxyhemoglobin, hemoglobin concentration and hematocrit were higher during RA compared to HA1. Conclusions: These results suggest that the retention of acclimatization after 8 d at low altitude is sufficient to attenuate AMS upon reinduction to high altitude. RP LYONS, TP (reprint author), USA,DIV ALTITUDE MED & PHYSIOL,USARIEM,NATICK,MA 01760, USA. NR 35 TC 27 Z9 27 U1 0 U2 3 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD OCT PY 1995 VL 66 IS 10 BP 957 EP 962 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA RX866 UT WOS:A1995RX86600006 PM 8526832 ER PT J AU Mekalanos, JJ Waldor, MK Gardel, CL Coster, TS Kenner, J Killeen, KP Beattie, DT Trofa, A Taylor, DN Sadoff, JC AF Mekalanos, JJ Waldor, MK Gardel, CL Coster, TS Kenner, J Killeen, KP Beattie, DT Trofa, A Taylor, DN Sadoff, JC TI Live cholera vaccines: Perspectives on their construction and safety SO BULLETIN DE L INSTITUT PASTEUR LA English DT Article ID VIBRIO-CHOLERAE; TOXIN GENES; IMMUNOGENICITY; STRAIN C1 USA,MED RES INST INFECT DIS,CLIN STUDIES BRANCH,DIV MED,FREDERICK,MD 21702. INST VIRUS RES,CAMBRIDGE,MA 02139. WALTER REED ARMY INST RES,DEPT CLIN TRIALS,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. RP Mekalanos, JJ (reprint author), HARVARD UNIV,SCH MED,DEPT MICROBIOL & MOLEC GENET,BOSTON,MA 02115, USA. NR 28 TC 16 Z9 19 U1 0 U2 0 PU EDITIONS SCIENTIFIQUES ELSEVIER PI PARIS CEDEX 15 PA 141 RUE JAVEL, 75747 PARIS CEDEX 15, FRANCE SN 0020-2452 J9 B I PASTEUR JI Bull. Inst. Pasteur PD OCT-DEC PY 1995 VL 93 IS 4 BP 255 EP 262 DI 10.1016/0020-2452(96)85759-9 PG 8 WC Immunology; Microbiology; Virology SC Immunology; Microbiology; Virology GA TW006 UT WOS:A1995TW00600005 ER PT J AU Szu, SC Gupta, R Kovac, P Taylor, DN Robbins, JB AF Szu, SC Gupta, R Kovac, P Taylor, DN Robbins, JB TI Development of O-specific polysaccharide-protein conjugates is based upon the protective effect of serum vibriocidal antibodies against cholera SO BULLETIN DE L INSTITUT PASTEUR LA English DT Article ID FIELD TRIAL; BANGLADESH; VACCINES; IMMUNITY; LIPOPOLYSACCHARIDES; IMMUNIZATION; INFECTION C1 NIH,BETHESDA,MD 20892. WALTER REED ARMY INST RES,WASHINGTON,DC 20014. NR 31 TC 3 Z9 3 U1 0 U2 0 PU EDITIONS SCIENTIFIQUES ELSEVIER PI PARIS CEDEX 15 PA 141 RUE JAVEL, 75747 PARIS CEDEX 15, FRANCE SN 0020-2452 J9 B I PASTEUR JI Bull. Inst. Pasteur PD OCT-DEC PY 1995 VL 93 IS 4 BP 269 EP 272 DI 10.1016/0020-2452(96)85761-7 PG 4 WC Immunology; Microbiology; Virology SC Immunology; Microbiology; Virology GA TW006 UT WOS:A1995TW00600007 ER PT J AU CHEN, ZP SAMUELSON, LA AKKARA, J KAPLAN, DL GAO, H KUMAR, J MARX, KA TRIPATHY, SK AF CHEN, ZP SAMUELSON, LA AKKARA, J KAPLAN, DL GAO, H KUMAR, J MARX, KA TRIPATHY, SK TI SOL-GEL ENCAPSULATED LIGHT-TRANSDUCING PROTEIN PHYCOERYTHRIN - A NEW BIOMATERIAL SO CHEMISTRY OF MATERIALS LA English DT Article ID FLUORESCENCE MICROSCOPY; BACTERIORHODOPSIN; STORAGE; PHYCOBILISOMES; GLASSES; FILMS AB An optically transparent biomaterial is produced by encapsulating a light-transducing protein, phycoerythrin, in a sol-gel matrix. Absorption and fluorescence measurements indicate that the protein not only retains its native optical properties in the sol-gel matrix but also shows an enhanced stability toward photodegradation. Two-photon induced fluorescence is observed from phycoerythrin in both solution and sol-gel matrices. The potential application of this biomaterial in biosensors, three-dimensional biomolecular imaging, and three-dimensional optical storage is discussed. C1 UNIV MASSACHUSETTS,CTR ADV MAT,DEPT PHYS,LOWELL,MA 01854. UNIV MASSACHUSETTS,CTR ADV MAT,DEPT CHEM,LOWELL,MA 01854. UNIV MASSACHUSETTS,CTR INTELLIGENT BIOMAT,DEPT PHYS,LOWELL,MA 01854. UNIV MASSACHUSETTS,CTR INTELLIGENT BIOMAT,DEPT CHEM,LOWELL,MA 01854. RP CHEN, ZP (reprint author), USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760, USA. NR 31 TC 40 Z9 40 U1 1 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0897-4756 J9 CHEM MATER JI Chem. Mat. PD OCT PY 1995 VL 7 IS 10 BP 1779 EP 1783 DI 10.1021/cm00058a005 PG 5 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA TB561 UT WOS:A1995TB56100006 ER PT J AU Pizzolato, WN DeHon, RA AF Pizzolato, WN DeHon, RA TI Lead-210 derived sedimentation rates from a North Louisiana paper-mill effluent reservoir SO CLAYS AND CLAY MINERALS LA English DT Article DE anatase; applied sedimentation; kaolin; lead-210; paper-mill effluent; pyrite; wetland degradation ID LAKE-SEDIMENTS; PB-210; GEOCHRONOLOGY; MARSH; IRON AB Lower Wham Brake is a cypress, rim-swamp artificially enclosed in 1950 as a 22 km(2) industrial reservoir by the International Paper Company (IPC)-Bastrop Mill, for regulating downstream water quality. Sediment cores were examined by XRD lo differentiate paper-mill effluent deposition from the underlying detrital sediments and by Pb-210 decay spectroscopy to determine sediment accretion rates. Anatase and kaolin from the IPC paper-mill effluent delineated a well-defined, anthropic, silty-day, A horizon above a clay, 2Ag horizon. Anatase concentrations were no greater than 1.7% in the A horizon and was absent in the underlying 2Ag1 horizon. Kaolin deposition was significantly correlated to the A horizon by an average increase of 84% above the kaolinite detrital background. Pyrite was detected in the A horizon as a transformation mineral following sulfur reduction of the paper-mill effluent. Five of the six sediment cores showed an inflection in the excess Pb-210 activity profile consistent with a present-day reduction in sediment supply. The average modern sedimentation rate was 0.05 cm yr(-1). Average sedimentation observed during historic accretion was 0.22 cm yr(-1), about 4.4 times greater than the modern rate of accretion. Reduction in sediment accretion can be attributed to upstream levees completed in 1934 and loss of organic accumulation following the 1950 reservoir impoundment. However, radiometric dating could not precisely correlate the geochronology of kaolin/anatase introduction due to complex oxidation/reduction cycles concurrent with the modern accretion regime. C1 NE LOUISIANA UNIV,DEPT GEOSCI,MONROE,LA 71209. RP Pizzolato, WN (reprint author), USA,CORPS ENGINEERS,WATERWAYS EXPT STN,GEOTECH LAB,CEWES GG YH,3909 HARRY FERRY RD,VICKSBURG,MS 39180, USA. NR 34 TC 3 Z9 3 U1 0 U2 4 PU CLAY MINERALS SOCIETY PI BOULDER PA PO BOX 4416, BOULDER, CO 80306 SN 0009-8604 J9 CLAY CLAY MINER JI Clay Clay Min. PD OCT PY 1995 VL 43 IS 5 BP 515 EP 524 DI 10.1346/CCMN.1995.0430501 PG 10 WC Chemistry, Physical; Geosciences, Multidisciplinary; Mineralogy; Soil Science SC Chemistry; Geology; Mineralogy; Agriculture GA TV225 UT WOS:A1995TV22500001 ER PT J AU DAO, HNV DACHMAN, AH AF DAO, HNV DACHMAN, AH TI CT FINDINGS OF REGRESSION IN INTRAABDOMINAL DESMOPLASTIC SMALL-CELL TUMOR SO CLINICAL IMAGING LA English DT Article DE ABDOMEN, NEOPLASM; METASTASES; REGRESSION; COMPUTED TOMOGRAPHY AB We report the computed tomographic (CT) findings in a patient with intraabdominal desmoplastic small-cell tumor before and after 10 weeks of chemotherapy. This tumor is a rare, frequently fatal neoplasm of the peritoneum, seen predominantly in young males. Initial CT demonstrated large intraperitoneal masses, hepatic metastases, retroperitoneal and right axillary lymphadenopathy, ascites, and pleural effusion. Follow-up CT showed marked decrease of the main tumor bulk and complete regression in the axillary nodes. C1 WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL,BETHESDA,MD. NR 6 TC 7 Z9 7 U1 0 U2 0 PU ELSEVIER SCIENCE PUBL CO INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0899-7071 J9 CLIN IMAG JI Clin. Imaging PD OCT-DEC PY 1995 VL 19 IS 4 BP 244 EP 246 DI 10.1016/0899-7071(94)00065-K PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA TC881 UT WOS:A1995TC88100005 PM 8564867 ER PT J AU VASSILOPOULOS, D SMALLRIDGE, RC TSOKOS, GC AF VASSILOPOULOS, D SMALLRIDGE, RC TSOKOS, GC TI EFFECTS OF AN AMINOSTEROID INHIBITOR OF PHOSPHOLIPASE C-DEPENDENT PROCESSES ON THE TCR-MEDIATED SIGNAL-TRANSDUCTION PATHWAY IN HUMAN T-CELLS SO CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY LA English DT Article ID PROTEIN-TYROSINE KINASES; HUMAN LYMPHOCYTE-T; ANTIGEN RECEPTOR; INTERLEUKIN-2 RECEPTOR; POLYMORPHONUCLEAR NEUTROPHILS; MONOCLONAL-ANTIBODIES; CALCIUM IONOPHORES; TUMOR PROMOTER; ACTIVATION; EXPRESSION AB Phospholipase C (PLC) is a key enzyme in the T cell antigen receptor (TCR)-mediated signal transduction pathway in human T cells. Agonist-induced PLC activation leads to a cascade of intracellular events that ultimately regulate gene transcription and T cell activation. We studied the effects of U-73122, a putative inhibitor of PLC-dependent events, on TCR/CD3 complex-mediated early and late events in human T cells. Both anti-CD3 monoclonal antibody-induced 1,4,5-inositol trisphosphate (IF,) and free intracytoplasmic calcium [Ca2+](i) increases were inhibited by U-73122 (0.05-0.1 mu M), but not by the related inactive analog, U-73343. U-73122 did not affect thapsigargin-evoked [Ca2+](i) increase in T cells, indicating a specific mode of inhibition of CD3 signaling. Late events in T cell activation like CD3-mediated T cell proliferation and mitogen-induced interleukin 2 receptor (IL2-R) expression were also inhibited by this agent. T cell proliferation induced by a combination of a phorbol ester and ionomycin was not affected by U-73122, Although an agonist effect on basal IF, and [Ca2+](i) levels was observed with high concentrations of U-73122, the inhibitor alone did not induce any proliferative effect or IL2-R expression in T cells. Our results demonstrate for the first time that U-73122 is a specific inhibitor of PLC-dependent processes in human T cells and could serve as a valuable tool for studying T cell signal transduction pathways. (C) 1995 Academic Press, Inc. C1 WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, DIV MED, DEPT CLIN PHYSIOL, WASHINGTON, DC 20307 USA. RP WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, DEPT CLIN INVEST, WASHINGTON, DC 20307 USA. NR 34 TC 13 Z9 13 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-1229 J9 CLIN IMMUNOL IMMUNOP JI Clin. Immunol. Immunopathol. PD OCT PY 1995 VL 77 IS 1 BP 59 EP 68 DI 10.1016/0090-1229(95)90137-X PG 10 WC Immunology; Pathology SC Immunology; Pathology GA RW789 UT WOS:A1995RW78900010 PM 7554485 ER PT J AU WALSH, DS LOOAREESUWAN, S VANIGANONTA, S VIRAVAN, C WEBSTER, HK AF WALSH, DS LOOAREESUWAN, S VANIGANONTA, S VIRAVAN, C WEBSTER, HK TI CUTANEOUS DELAYED-TYPE HYPERSENSITIVITY RESPONSIVENESS IN PATIENTS DURING AND AFTER PLASMODIUM-FALCIPARUM AND PLASMODIUM-VIVAX INFECTIONS SO CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY LA English DT Article ID CELL-MEDIATED-IMMUNITY; MALARIA; PARASITEMIA; ANTIGENS; IL-2 AB To assess cellular immune function in malaria, 61 patients admitted to the Bangkok Hospital for Tropical Diseases with Plasmodium falciparum (PF) or Plasmodium vivax malaria were examined with the MULTITEST CMI system (Merieux Institute, Florida) to evaluate delayed-type hypersensitivity (DTH) during and after acute disease over 4 weeks. All patients demonstrated significantly decreased responsiveness to seven commonly encountered recall antigens. This deficit was most severe immediately upon admission (prior to therapy). Uncomplicated Pf cases demonstrated significant hyporesponsiveness only during Week 1. Responses in moderate/severe falciparum and all vivax patients gradually increased in Weeks 2 and 3 but remained significantly below control values. This study confirms functional cell-mediated immune deficits in falciparum malaria and, for the first time, shows hyporesponsiveness in vivax malaria. We conclude that malaria causes a pronounced CMI deficit that is still detectable in some individuals for 3-4 weeks after treatment of acute infection. These changes in DTH should be a consideration in future vaccine development and in evaluation of immune status in endemic areas. (C) 1995 Academic Press, Inc. C1 MAHIDOL UNIV,BANGKOK HOSP TROP DIS,FAC TROP MED,BANGKOK 10700,THAILAND. USA,ARMED FORCES RES INST MED SCI,MED COMPONENT,DEPT IMMUNOL,BANGKOK,THAILAND. NR 19 TC 12 Z9 12 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 SN 0090-1229 J9 CLIN IMMUNOL IMMUNOP JI Clin. Immunol. Immunopathol. PD OCT PY 1995 VL 77 IS 1 BP 89 EP 94 DI 10.1016/0090-1229(95)90141-8 PG 6 WC Immunology; Pathology SC Immunology; Pathology GA RW789 UT WOS:A1995RW78900014 PM 7554489 ER PT J AU MAMMEN, MP ARONSON, NE EDENFIELD, WJ ENDY, TP AF MAMMEN, MP ARONSON, NE EDENFIELD, WJ ENDY, TP TI RECURRENT HELICOBACTER-CINAEDI BACTEREMIA IN A PATIENT INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS - CASE-REPORT SO CLINICAL INFECTIOUS DISEASES LA English DT Note ID CAMPYLOBACTER-CINAEDI C1 WALTER REED ARMY MED CTR,DEPT MED,INFECT DIS SERV,WASHINGTON,DC 20307. NR 4 TC 26 Z9 27 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD OCT PY 1995 VL 21 IS 4 BP 1055 EP 1055 PG 1 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA RZ139 UT WOS:A1995RZ13900058 PM 8645814 ER PT J AU FRIEDLANDER, AM WELKOS, SL WORSHAM, PL ANDREWS, GP HEATH, DG ANDERSON, GW PITT, MLM ESTEP, J DAVIS, K AF FRIEDLANDER, AM WELKOS, SL WORSHAM, PL ANDREWS, GP HEATH, DG ANDERSON, GW PITT, MLM ESTEP, J DAVIS, K TI RELATIONSHIP BETWEEN VIRULENCE AND IMMUNITY AS REVEALED IN RECENT STUDIES OF THE F1 CAPSULE OF YERSINIA-PESTIS SO CLINICAL INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT Abraham I Braude Memorial Symposium on Infectious Diseases CY JUL 08-09, 1994 CL UNIV CALIF SAN DIEGO, MED SCH, SAN DIEGO, CA SP Univ Calif San Diego, Sch Med, Div Infectious Dis HO UNIV CALIF SAN DIEGO, MED SCH ID V-ANTIGEN; Y-PESTIS; PROTEIN; GENE; PSEUDOTUBERCULOSIS; EXPRESSION; OPERON AB Yersinia pestis, the causative agent of plague, possesses multiple virulence determinants encoded on its three plasmids and on its chromosome. We evaluated the role of the protein capsule F1 in virulence and immunity against plague. Strains lacking F1, either those that are naturally occurring or those with genetically defined nonpolar mutations in the structural gene, retained their virulence for mice and nonhuman primates. However, both active immunization with F1, from either a recombinant vector or Y. pestis, and passive immunization with F1 monoclonal antibody protected mice from experimental infection with wild-type F1-positive organisms, These results suggest that protective immunogens like F1 need not be essential for virulence. The rare isolation of virulent F1-negative organisms from F1-immunized animals infected with F1-positive strains supports this conclusion and also suggests that, in addition to F1, an optimal vaccine against plague should include essential virulence factors as immunogens. C1 USA,MED RES INST INFECT DIS,DIV TOXINOL,FREDERICK,MD. USA,MED RES INST INFECT DIS,DIV PATHOL,FREDERICK,MD. RP FRIEDLANDER, AM (reprint author), USA,MED RES INST INFECT DIS,DIV BACTERIOL,FREDERICK,MD 21702, USA. NR 28 TC 74 Z9 77 U1 0 U2 4 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD OCT PY 1995 VL 21 SU 2 BP S178 EP S181 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA RZ527 UT WOS:A1995RZ52700009 PM 8845449 ER PT J AU ARCIERO, RA STPIERRE, P AF ARCIERO, RA STPIERRE, P TI ACUTE SHOULDER DISLOCATION - INDICATIONS AND TECHNIQUES FOR OPERATIVE MANAGEMENT SO CLINICS IN SPORTS MEDICINE LA English DT Article AB This article reviews the natural history of the initial traumatic anterior shoulder dislocation. The literature is compared with the experience at the US Military Academy in a uniform group of young athletes. The concept and rationale for acute arthroscopic stabilization are introduced. Operative indications and the current arthroscopic technique are detailed. RP ARCIERO, RA (reprint author), KELLY ARMY HOSP,ORTHOPAED SERV,USA JOINT & SOFT TISSUE TRAUMA FELLOWSHIP SPORTS,W POINT,NY 10996, USA. NR 0 TC 25 Z9 25 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0278-5919 J9 CLIN SPORT MED JI Clin. Sports Med. PD OCT PY 1995 VL 14 IS 4 BP 937 EP & PG 0 WC Sport Sciences SC Sport Sciences GA RY985 UT WOS:A1995RY98500012 PM 8582007 ER PT J AU WHITLOCK, W AF WHITLOCK, W TI MULTICENTER COMPARISON OF AZITHROMYCIN AND AMOXICILLIN/CLAVULANATE IN THE TREATMENT OF PATIENTS WITH ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY-DISEASE SO CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL LA English DT Article ID INFECTIONS; MACROLIDES; COPD AB This randomized, multicenter, investigator-blinded, parallel-group study compared a 5-day, once-daily course of azithromycin (two 250-mg capsules on day 1, followed by one 250-mg capsule on days 2 through 5) with a 10-day, three-times-daily course of amoxicillin/clavulanate (one 500-mg tablet) in 70 patients with acute bacterial exacerbations of chronic obstructive pulmonary disease (COPD; chronic bronchitis). At the end of therapy, all 29 (100%) efficacy-assessable patients treated with azithromycin were cured or improved, compared with 25 (93%) of 27 assessable patients given amoxicillin/clavulanate (P = NS). Bacteriologic eradication rates were 86% (25/29 isolates) with azithromycin and 87% (20/23 isolates) with the comparative agent. Azithromycin was well tolerated; adverse events considered related or possibly related to treatment were reported in 28% of azithromycin recipients, compared with 39% of amoxicillin/clavulanate recipients (P = NS). The 5-day, once-daily regimen-of azithromycin is comparable to a standard agent in the treatment of patients with acute bacterial exacerbations of COPD. RP WHITLOCK, W (reprint author), DWIGHT D EISENHOWER ARMY MED CTR,PULM DIS SECT,FT GORDON,GA 30905, USA. NR 28 TC 11 Z9 12 U1 0 U2 0 PU EXCERPTA MEDICA INC PI BELLE MEAD PA 105 RAIDER BLVD, BELLE MEAD, NJ 08502 SN 0011-393X J9 CURR THER RES CLIN E JI Curr. Ther. Res.-Clin. Exp. PD OCT PY 1995 VL 56 IS 10 BP 985 EP 995 DI 10.1016/0011-393X(95)85105-4 PG 11 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA TB657 UT WOS:A1995TB65700001 ER PT J AU TANSEL, B REGULA, J SHALEWITZ, R AF TANSEL, B REGULA, J SHALEWITZ, R TI TREATMENT OF FUEL-OIL AND CRUDE-OIL CONTAMINATED WATERS BY ULTRAFILTRATION MEMBRANES SO DESALINATION LA English DT Article; Proceedings Paper CT 1994 Biennial Conference and Exposition on Membrane and Desalting Technologies CY SEP 11-15, 1994 CL PALM BEACH, FL SP Amer Desalting Assoc, Int Desalting Assoc, WateReuse Assoc Calif AB This study evaluates the effectiveness of ultrafiltration technology for treatment of fuel oil and crude oil contaminated waters. The experiments were conducted by using a laboratory scale continuous cross-flow membrane filtration system manufactured by Desalination Systems, Inc. (DSI). The unit has a maximum operating pressure of 200 psig (13.8 bar) and can be operated in parallel mode with two membranes, each with a 12 in(2) area. The water samples were prepared by using either a light crude oil (Boney light) or a mixture of jet fuel, diesel and unleaded gasoline at contamination levels of 150 and 3,000 ppm. The G-50 thin-film composite (TFC) membrane, manufactured by Desalination Systems Inc., was used in the experiments. The G-50 membrane was selected after a series of membrane screening tests. The effectiveness of coagulation prior to ultrafiltration was also studied by using Cat-flee K-10, which was selected after a series of coagulant screening tests. C1 USA,BELVOIR RES DEV & ENGN CTR,FT BELVOIR,VA 22050. RP TANSEL, B (reprint author), FLORIDA INT UNIV,DEPT CIVIL & ENVIRONM ENGN,UNIV PK CAMPUS,MIAMI,FL 33199, USA. NR 15 TC 42 Z9 49 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0011-9164 J9 DESALINATION JI Desalination PD OCT PY 1995 VL 102 IS 1-3 BP 301 EP 311 DI 10.1016/0011-9164(95)00067-C PG 11 WC Engineering, Chemical; Water Resources SC Engineering; Water Resources GA TE662 UT WOS:A1995TE66200032 ER PT J AU STALLWORTH, PE GREENBAUM, SG CROCE, F SLANE, S SALOMON, M AF STALLWORTH, PE GREENBAUM, SG CROCE, F SLANE, S SALOMON, M TI LI-7 NMR AND IONIC-CONDUCTIVITY STUDIES OF GEL ELECTROLYTES BASED ON POLY(METHYLMETHACRYLATE) SO ELECTROCHIMICA ACTA LA English DT Article; Proceedings Paper CT 5th International Symposium on Polymer Electrolytes (ISPE4) CY JUN 21-25, 1994 CL NEWPORT, RI SP Ciba Geigy Japan Ltd, Cyprus Foote Mineral Co, Dai Ichi Kogyo Seiyaku Co Ltd, Duracell Int Inc, Ever Ready Battery Co Inc, USN, Off Naval Res, Yuasa Corp DE ELECTROLYTE; PMMA; LI-7 NMR; IONIC CONDUCTIVITY ID POLYMER AB Gel electrolytes synthesized from poly(methylmethacrylate), ethylene carbonate, propylene carbonate and various lithium salts [LiClO4, LiAsF6, or LiN(CF3SO2)(2)] have been investigated by differential scanning calorimetry, electrical conductivity, and Li-7, F-19 and As-75 NMR spectroscopy. Although the ionic conductivities of the gels approach those of liquid electrolytes above room temperature, the NMR results indicate that the immediate environments of both the cations and anions differ significantly in the gel and in the liquid. Thus the presence of microscopic regions of pure liquid electrolyte in the gel can be ruled out. C1 UNIV ROME,DEPT CHEM,ROME,ITALY. USA,EPSD,RES LAB,FT MONMOUTH,NJ 07703. USN ACAD,DEPT PHYS,ANNAPOLIS,MD 21402. RP STALLWORTH, PE (reprint author), CUNY HUNTER COLL,DEPT PHYS,NEW YORK,NY 10021, USA. RI Croce, Fausto/J-8193-2012 NR 10 TC 71 Z9 72 U1 0 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0013-4686 J9 ELECTROCHIM ACTA JI Electrochim. Acta PD OCT PY 1995 VL 40 IS 13-14 BP 2137 EP 2141 DI 10.1016/0013-4686(95)00153-6 PG 5 WC Electrochemistry SC Electrochemistry GA RU089 UT WOS:A1995RU08900017 ER PT J AU LAZAS, DJ MOSES, FM WONG, RKH AF LAZAS, DJ MOSES, FM WONG, RKH TI VIDEOENDOSCOPIC ANOSCOPY - A NEW TECHNIQUE FOR EXAMINING THE ANAL-CANAL SO GASTROINTESTINAL ENDOSCOPY LA English DT Article ID HEMORRHOIDS; MANAGEMENT C1 WALTER REED ARMY MED CTR,DEPT GASTROENTEROL,WASHINGTON,DC 20307. NR 9 TC 3 Z9 3 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD OCT PY 1995 VL 42 IS 4 BP 351 EP 354 DI 10.1016/S0016-5107(95)70136-2 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA TA715 UT WOS:A1995TA71500014 PM 8536906 ER PT J AU NI, TD STURZEBECHER, D PAOLELLA, A PERLMAN, B AF NI, TD STURZEBECHER, D PAOLELLA, A PERLMAN, B TI NOVEL POLYMER OPTICAL COUPLERS BASED ON SYMMETRY MODE MIXING SO IEEE PHOTONICS TECHNOLOGY LETTERS LA English DT Article ID WAVE-GUIDES; BENDS AB Emerging mixed signal modules will contain microwave, digital, and photonic circuits requiring efficient interconnect technology due to space limitation. Polymers are envisioned to perform optical interconnections via waveguides, and distribution networks via optical couplers. A novel polymer optical coupler, using center-fed mode mixing for multimode waveguide, is demonstrated experimentally for use in a mixed-signal mode environment. This coupler has lower loss and space requirement than the traditional Y-junction coupler, A limitation of this type of coupler is the small separation of the output beams. To circumvent this a microprism is introduced for wide-angle applications. RP NI, TD (reprint author), USA,RES LAB,PHYS SCI DIRECTORATE,AMSRL PS E,FT MONMOUTH,NJ 07703, USA. NR 10 TC 4 Z9 4 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 1041-1135 J9 IEEE PHOTONIC TECH L JI IEEE Photonics Technol. Lett. PD OCT PY 1995 VL 7 IS 10 BP 1186 EP 1188 DI 10.1109/68.466585 PG 3 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA RZ222 UT WOS:A1995RZ22200030 ER PT J AU BHASKARAN, S SINGH, VP MORTON, DC AF BHASKARAN, S SINGH, VP MORTON, DC TI ELECTRON EJECTION PROCESSES AT INSULATOR-SEMICONDUCTOR INTERFACES IN ACTFEL DISPLAY DEVICES SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article ID FILM ELECTROLUMINESCENT DEVICES; SIMPLE-MODEL; FIELD AB Luminance, conduction current and threshold voltage of ZnS:Mn ac thin film electroluminescent display devices were measured as functions of device temperature (10 K-300 K) and risetime of the excitation voltage pulse (2 mu s-50 mu s). Results provided insight into the electron ejection mechanism at the insulator-phosphor interfaces. It was found that the distribution of interface state electrons at the beginning of the excitation voltage pulse varied substantially with device temperature. Pure tunneling is thought to be the dominant electron ejection mechanism at the beginning of the voltage pulse while phonon-assisted tunneling is responsible for altering the interface electron distribution during the interval between the pulses. A delay of several microseconds was observed in the build up of the transferred charge. It is attributed to the relatively small population of electrons available at the insulator-phosphor interface. C1 USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703. RP BHASKARAN, S (reprint author), UNIV TEXAS,DEPT ELECT & COMP ENGN,EL PASO,TX 79968, USA. NR 20 TC 4 Z9 4 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD OCT PY 1995 VL 42 IS 10 BP 1756 EP 1762 DI 10.1109/16.464422 PG 7 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA RW010 UT WOS:A1995RW01000006 ER PT J AU TURBYFILL, KR JOSEPH, SW OAKS, EV AF TURBYFILL, KR JOSEPH, SW OAKS, EV TI RECOGNITION OF 3 EPITOPIC REGIONS ON INVASION PLASMID ANTIGEN-C BY IMMUNE SERA OF RHESUS-MONKEYS INFECTED WITH SHIGELLA-FLEXNERI 2A SO INFECTION AND IMMUNITY LA English DT Article ID LIPOPOLYSACCHARIDE O-ANTIGEN; B-CELL EPITOPES; ANTIBODY-RESPONSES; MOLECULAR-CLONING; PEPTIDE-SYNTHESIS; AMINO-ACID; PROTEIN; IDENTIFICATION; SONNEI; GENES AB The invasive ability of Shigella spp. is correlated with the expression of several plasmid-encoded proteins, including invasion plasmid antigen C (IpaC). By characterizing the antigenic structure of IpaC with monoclonal clonal antibodies and convalescent-phase sera, it may be possible to determine the physical location of specific epitopes as well as the involvement of epitopes in a protective immune response or the host's susceptibility to disease. By using overlapping octameric synthetic peptides, which together represent the entire IpaC protein, the precise linear sequence of four surface-exposed epitopes was defined for four IpaC monoclonal antibodies. Furthermore, 17 unique peptide epitopes of IpaC were mapped by using 9-day-postinfection serum samples from 13 rhesus monkeys challenged with Shigella flexneri 2a. Each individual recognized a somewhat different array of IpaC peptide epitopes after infection with shigellae. However, the epitopes were clustered within three regions of the protein: region I (between amino acid residues 1 and 61), region II (between amino acid residues 177 and 258), and region III (between amino acid residues 298 and 307). Region II was recognized by 92% of S. flexneri-infected individuals and was considered to be a highly immunogenic region. Animals asymptomatic for shigellosis after challenge with S. flexneri recognized peptide epitopes within all three epitopic regions of IpaC, whereas symptomatic animals recognized peptides in only one or two of the epitopic regions. Antibody from monkeys challenged with S. sonnei recognized IpaC peptide epitopes which fell within and outside the three S. flexneri epitopic regions. While numerous potential epitopes exist on the IpaC protein, the identification of three regions in which epitopes are clustered suggests that these regions are significant with respect to the immune response and to subsequent pathogenesis postinfection. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTER INFECT,WASHINGTON,DC 20307. UNIV MARYLAND,DEPT MICROBIOL,COLLEGE PK,MD 20742. NR 36 TC 17 Z9 18 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD OCT PY 1995 VL 63 IS 10 BP 3927 EP 3935 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA RW006 UT WOS:A1995RW00600026 PM 7558301 ER PT J AU RENZULLO, PO MCNEIL, JG WANN, ZF BURKE, DS BRUNDAGE, JF AF RENZULLO, PO MCNEIL, JG WANN, ZF BURKE, DS BRUNDAGE, JF TI HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 SEROCONVERSION TRENDS AMONG YOUNG-ADULTS SERVING IN THE UNITED-STATES-ARMY, 1985-1993 SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE HIV-1 INCIDENCE; SEROCONVERSION; EPIDEMIOLOGY; TEMPORAL TRENDS ID MULTICENTER AIDS COHORT; FRANCISCO MENS HEALTH; HIV SEROCONVERSION; HOMOSEXUAL MEN; BISEXUAL MEN; INFECTION; PREVALENCE; EPIDEMIOLOGY; MILITARY; PROGRAM AB The direct measurement of the incidence of new infections with the human immunodeficiency virus type 1 (HIV-1) can be made among soldiers because of the routine and periodic nature of HIV-1 testing in the United States Army. Between November 1985 and October 1993, 978 HIV-1 seroconversions were seen among 1,061,768 soldiers, contributing over 3.6 million person-years of follow-up [seroconversion rate (95% confidence interval) = 0.27/1,000 person-years (0.25-0.29)]. A significant decreasing trend in HIV-1 seroconversion rates was seen over the analysis period. The rate of new infections declined significantly from the first interval, 1985-1987, (0.43/1,000 person-years) to the second interval, 1987-1988, (0.28/1,000 person-years), but stabilized at similar to 0.22/1,000 person-years after 1988, representing new infections in similar to 101-150 soldiers annually. The risk of seroconversion among active duty soldiers was significantly associated with racial/ethnic group, age, gender, and marital status. Surveillance of HIV-1 seroconversion rates in the U.S. Army continues to offer a unique opportunity to assess temporal trends in the evolving HIV-1 infection epidemic. Monitoring the rate of new HIV-1 infections allows for identification of subgroups in need of intervention, refocusing of intervention strategies, and evaluation of their effectiveness. C1 WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD 20850. ALLIED TECHNOL GRP INC,ROCKVILLE,MD. RP RENZULLO, PO (reprint author), WALTER REED ARMY INST RES,DIV PREVENT MED,1 TAFT COURT,SUITE 250,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 NR 40 TC 15 Z9 15 U1 1 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD OCT 1 PY 1995 VL 10 IS 2 BP 177 EP 185 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA RW330 UT WOS:A1995RW33000011 PM 7552483 ER PT J AU TENCH, DM ANDERSON, DP JAMBAZIAN, P KIM, P WARREN, LF HILLMAN, D LUCEY, GK AF TENCH, DM ANDERSON, DP JAMBAZIAN, P KIM, P WARREN, LF HILLMAN, D LUCEY, GK TI REDUCTION OF METALLIC SURFACE OXIDES VIA AN ELECTROCHEMICALLY-GENERATED REDOX SPECIES SO JOURNAL OF APPLIED ELECTROCHEMISTRY LA English DT Article AB A new method is described for removing oxides from metallic surfaces via electroless reduction by the reducing member of a redox couple that is electrochemically regenerated in a closed loop. On tin-lead coatings, which are widely used to enhance the solderability retention of electronic components and circuit boards, naturally-formed oxides are reduced to the metallic state within ten seconds by either vanadous or chromous ions in acidic sulfate solution. Wetting balance data for wire specimens show that this reduction treatment is an effective means of restoring and ensuring solderability. C1 ROCKWELL INT CORP,COLLINS AVION & COMMUN DIV,CEDAR RAPIDS,IA 52498. USA,RES LABS,ADELPHI,MD 20783. RP TENCH, DM (reprint author), ROCKWELL INT SCI CTR,1049 CAMINO DOS RIOS,THOUSAND OAKS,CA 91360, USA. NR 13 TC 1 Z9 1 U1 0 U2 0 PU CHAPMAN HALL LTD PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8HN SN 0021-891X J9 J APPL ELECTROCHEM JI J. Appl. Electrochem. PD OCT PY 1995 VL 25 IS 10 BP 947 EP 952 PG 6 WC Electrochemistry SC Electrochemistry GA TA702 UT WOS:A1995TA70200006 ER PT J AU NASTROM, GD EATON, FD AF NASTROM, GD EATON, FD TI VARIATIONS OF WINDS AND TURBULENCE SEEN BY THE 50-MHZ RADAR AT WHITE-SANDS-MISSILE-RANGE, NEW-MEXICO SO JOURNAL OF APPLIED METEOROLOGY LA English DT Article ID MU-RADAR; LOWER STRATOSPHERE; MIDDLE ATMOSPHERE; POKER FLAT; MST RADAR; TROPOSPHERE; DISTURBANCES; PROFILER; ALASKA AB mean vertical profiles of the winds from about 5 to 20 km at White Sands Missile Range, New Mexico, are described. The variability of wind speed, spectral width, volume reflectivity calibrated as C-N(2), and vertical wind shear are documented as functions of season and of time of day using observations taken from 1991 through April 1994 with the 50-MHz profiling radar. The mean meridional winds are from the south at about 1-3 m s(-1) during every season except autumn, and mean zonal winds have a broad jet near the tropopause with maximum speed over 30 m s(-1) during the winter. The mean vertical velocity is downward at about 5 cm s(-1) in the troposphere and is weakly upward in the lower stratosphere. The shear of the mean wind and the mean wind shear have small interseasonal variability. The variance over 1-h periods of all three wind components, the spectral width, and C-N(2) have lognormal frequency distributions. The variance of the meridional wind speed is greater than that of the zonal wind speed in the troposphere, but in the stratosphere during winter and spring the variance of the zonal wind speed is greater. The mean profiles of logC(N)(2) in the stratosphere are nearly constant with altitude and from season to season, ranging over only a few decibels. Diurnal cycles of wind speed have amplitudes on the order of 1 m s(-1), but the phases are highly variable with height and season, suggesting strong local topographic control of the observed diurnal cycles. The diurnal cycles of C-N(2), spectral width, and of the variance of the vertical velocity have the largest amplitudes in the troposphere where the daily maxima are during the afternoon. C1 USA,RES LAB,WHITE SANDS MISSILE RANGE,NM. RP NASTROM, GD (reprint author), ST CLOUD STATE UNIV,DEPT EARTH SCI,720 4TH AVE S,ST CLOUD,MN 56301, USA. NR 27 TC 31 Z9 31 U1 0 U2 1 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 SN 0894-8763 J9 J APPL METEOROL JI J. Appl. Meteorol. PD OCT PY 1995 VL 34 IS 10 BP 2135 EP 2148 DI 10.1175/1520-0450(1995)034<2135:VOWATS>2.0.CO;2 PG 14 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA RW334 UT WOS:A1995RW33400002 ER PT J AU DHAR, NK WOOD, CEC AF DHAR, NK WOOD, CEC TI CRYSTALLIZED AMORPHOUS DEPOSITS FOR RELAXED EPITAXY - CDTE(001) ON GAAS(001) SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID GROWTH; CDTE; GAAS; LAYERS AB When annealed, thin amorphous deposits of highly lattice mismatched materials provide specular crystalline surfaces for epitaxy. Mismatch strain is predominantly relieved by misfit dislocations propagating in the plane of the interface, so that resulting films have low threading dislocation densities. We demonstrate the application of this concept to the growth of (001) oriented CdTe epitaxy on (001) GaAs. (C) 1995 American Institute of Physics. C1 UNIV MARYLAND,DEPT ELECT ENGN,COLLEGE PK,MD 20740. RP DHAR, NK (reprint author), USA,RES LAB,FT BELVOIR,VA 22060, USA. NR 13 TC 2 Z9 2 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD OCT 1 PY 1995 VL 78 IS 7 BP 4463 EP 4466 DI 10.1063/1.359855 PG 4 WC Physics, Applied SC Physics GA RW892 UT WOS:A1995RW89200024 ER PT J AU KUDLICKI, W ODOM, OW MERRILL, G KRAMER, G HARDESTY, B AF KUDLICKI, W ODOM, OW MERRILL, G KRAMER, G HARDESTY, B TI INHIBITION OF THE RELEASE FACTOR-DEPENDENT TERMINATION REACTION ON RIBOSOMES BY DNAJ AND THE N-TERMINAL PEPTIDE OF RHODANESE SO JOURNAL OF BACTERIOLOGY LA English DT Article ID BOVINE LIVER RHODANESE AB A peptide consisting of the 17 N-terminal amino acids of native bovine rhodanese in combination with the chaperone DnaJ specifically inhibits release factor- and stop codon-dependent hydrolysis of N-formylmethionine from N(formyl)-methionyl-tRNA bound with AUG to salt-washed ribosomes. Neither the peptide nor DnaJ by itself causes this inhibition. The N-terminal peptide and DnaJ both singularly and combined do not affect the peptidyltransferase reaction per se. The total amount of rhodanese synthesized in the cell-free coupled transcription-translation system is reduced by the peptide, with concomitant accumulation of full-length enzymatically inactive rhodanese polypeptides on ribosomes. In combination with DnaJ, the N-terminal polypeptide inhibits the termination and release of full-length rhodanese peptides that have accumulated on Escherichia coli ribosomes during the course of uninhibited coupled transcription-translation in the cell-free system. This inhibition appears to involve release factor 2-mediated termination at the UGA termination codon in the coding sequence for rhodanese. It is suggested that the N-terminal peptide inhibits the binding of the release factor to ribosomes. These data appear to provide the first report of differential inhibition of the termination reaction on ribosomes without inhibition of the peptidyltransferase reaction and peptide elongation. C1 UNIV TEXAS, DEPT CHEM & BIOCHEM, AUSTIN, TX 78712 USA. BROOKE ARMY MED CTR, DEPT CLIN INVEST, FT SAM HOUSTON, TX 78234 USA. NR 20 TC 7 Z9 7 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0021-9193 J9 J BACTERIOL JI J. Bacteriol. PD OCT PY 1995 VL 177 IS 19 BP 5517 EP 5522 PG 6 WC Microbiology SC Microbiology GA RX423 UT WOS:A1995RX42300017 PM 7559337 ER PT J AU Bracuti, AJ AF Bracuti, AJ TI Crystal structure of 2,4-dinitroimidazole (24DNI) SO JOURNAL OF CHEMICAL CRYSTALLOGRAPHY LA English DT Article DE aromatic molecules; energetic molecules; nitroimidazoles; oxidizers; propellants AB A single-crystal X-ray diffraction study verified that the target oxidizer molecule 2,4-dinitroimidazole (24DNI) had been synthesized by thermal rearrangement of 1,4-dinitroimidazole 24DNI crystallizes in the orthorhombic space group Pbca with unit-cell dimensions a = 10.127(2), b = 18.497(2), c = 6.333(2) Angstrom, and Z = 8 and has a density of 1.770 g/cm(3). The molecular packing consists of hydrogen-bonded chains of 24DNI molecules [N(1)-H(1) ... N(3)] in the a direction which are held together in the lateral direction by molecular forces. Some structural features of 24DNI are compared with those of 1,4-dinitroimidazole. RP Bracuti, AJ (reprint author), USA,ARDEC,DIV ENERGET & WARHEADS,PICATINNY ARSENAL,NJ 07806, USA. RI G, Neela/H-3016-2014 NR 7 TC 50 Z9 57 U1 0 U2 1 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 1074-1542 J9 J CHEM CRYSTALLOGR JI J. Chem. Crystallogr. PD OCT PY 1995 VL 25 IS 10 BP 625 EP 627 DI 10.1007/BF01665967 PG 3 WC Crystallography; Spectroscopy SC Crystallography; Spectroscopy GA TL437 UT WOS:A1995TL43700002 ER PT J AU WEIMASTER, JF BEAUDRY, WT BOSSLE, PC ELLZY, MW JANES, LG JOHNSON, DW LOCHNER, JM PLEVA, SG REEDER, JH ROHRBAUGH, DK ROSSO, TE SZAFRANIEC, LJ SZAFRANIEC, LL ALBRO, TG CREASY, WR STUFF, JR SMITH, PB STEWART, IR AF WEIMASTER, JF BEAUDRY, WT BOSSLE, PC ELLZY, MW JANES, LG JOHNSON, DW LOCHNER, JM PLEVA, SG REEDER, JH ROHRBAUGH, DK ROSSO, TE SZAFRANIEC, LJ SZAFRANIEC, LL ALBRO, TG CREASY, WR STUFF, JR SMITH, PB STEWART, IR TI CHEMICAL-ANALYSIS OF ENVIRONMENTAL-SAMPLES COLLECTED IN IRAQ - ANALYSIS FOR THE PRESENCE OF CHEMICAL WARFARE AGENTS SO JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY LA English DT Article DE CHEMICAL WARFARE AGENTS; CHEMICAL WEAPONS CONVENTION; IRAQ ID HYDROLYSIS AB Nineteen samples from the United Nations Special Commission 65 on Iraq (UNSCOM 65) were analyzed for chemical warfare (CW) related compounds using a variety of spectroscopic and chromatographic techniques including multinuclear NMR, GC (phosphorus, sulfur and atomic emission detection), GC/MS (electron impact and chemical ionization), tandem MS, HPLC/ion chromatography, HPLC/thermospray/MS, FTIR, ICP and GFAA. The samples consisted of one piece of cloth, one piece of wood, six waters, six soils, two vegetation samples and two mortar shell crosscut sections. No intact CW agents were detected; however, diethyl phosphoric acid was unambiguously identified in three of the water samples and ethyl phosphoric acid was tentatively identified, at lower levels, in one of the water samples. Diethyl phosphoric acid and ethyl phosphoric acid are degradation products of munitions-grade Tabun (GA), an organophosphorus nerve agent. However, these compounds are also degradation products of the Chemical Weapons Convention (CWC) scheduled compound Amiton as well as many commercially available pesticides. C1 USA,EDGEWOOD RES DEV & ENGN CTR,RES & TECHNOL DIRECTORATE,ABERDEEN PROVING GROUND,MD 21010. NR 9 TC 15 Z9 16 U1 1 U2 7 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0268-2575 J9 J CHEM TECHNOL BIOT JI J. Chem. Technol. Biotechnol. PD OCT PY 1995 VL 64 IS 2 BP 115 EP 128 DI 10.1002/jctb.280640203 PG 14 WC Biotechnology & Applied Microbiology; Chemistry, Multidisciplinary; Engineering, Environmental; Engineering, Chemical SC Biotechnology & Applied Microbiology; Chemistry; Engineering GA RY547 UT WOS:A1995RY54700002 ER PT J AU DALSGAARD, A ALBERT, MJ TAYLOR, DN SHIMADA, T MEZA, R SERICHANTALERGS, O ECHEVERRIA, P AF DALSGAARD, A ALBERT, MJ TAYLOR, DN SHIMADA, T MEZA, R SERICHANTALERGS, O ECHEVERRIA, P TI CHARACTERIZATION OF VIBRIO-CHOLERAE NON-O1 SEROGROUPS OBTAINED FROM AN OUTBREAK OF DIARRHEA IN LIMA, PERU SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID THERMOSTABLE DIRECT HEMOLYSIN; ENTEROTOXIN NAG-ST; ESCHERICHIA-COLI; OLIGONUCLEOTIDE PROBE; TOXIN; PURIFICATION; STRAINS; PARAHAEMOLYTICUS; RABBIT; DNA AB In February 1994, an outbreak of diarrhea caused by non-Ol Vibrio cholerae occurred among volunteers in a vaccine trial study area in Lima, Peru, Clinically, 95% of the patients presented,vith liquid diarrhea with either no or mild dehydration, Serogrouping of 58 isolates recovered from diarrheal patients affected in the outbreak revealed seven different serogroups, with serogroups O10 (21%) and O12 (65%) being predominant, Most of these isolates were susceptible to a variety of antimicrobial agents. None of the 58 isolates hybridized with a DNA probe previously used to detect the gene encoding the heat-stable enterotoxin NAG-ST or produced cholera toxin as assessed by GM, ganglioside enzyme-linked immunosorbent assay, Ribotyping exhibited 10 different Bg/I: ribotype patterns among the 58 V: cholerae non Ol strains studied. However, ribotyping showed that all isolates belonging to serogroup O12 exhibited identical ribotypes and that 83% of the serogroup O10 isolates belonged to another identical ribotype, thus showing excellent correlation between ribotypes and serogroups. Among a group of O10 and O12 isolates selected for virulence studies, none produced enterotoxin whereas the majority produced a cytotoxin, as assessed in Y1 and HeLa cells, These isolates were also negative for the gene encoding zonula occludens toxin (Zot) as assessed by a PCR assay, The isolates tested showed strong adherence and some degree of invasion in the HEp-2 cell assay, whereas none of the isolates was positive in the PCR assay for the gene encoding the toxin coregulated pilus subunit A antigen (tcpA), In the removable intestinal tie adult rabbit diarrhea model, O10 and O12 serogroup isolates produced severe diarrhea and occasionally death when rabbits were challenged with 10(10) bacterial cells, Fluid accumulation was shown in the rabbit intestinal loop test when whole cultures were injected, No significant difference in virulence was shown between serogroup O10 and O12 isolates, This study provides further evidence that V cholerae non-Ol non-O139 strains have diarrhegenic potential for humans through a yet-undefined mechanism(s) and that such strains can cause outbreaks. C1 INT CTR DIARRHOEAL DIS RES,DHAKA 1000,BANGLADESH. USN,MED RES INST DETACHMENT,DEPT MICROBIOL,LIMA,PERU. USN,MED RES INST DETACHMENT,DEPT MED ECOL,LIMA,PERU. NATL INST HLTH,DEPT BACTERIOL,SHINJUKU KU,TOKYO,JAPAN. ARMED FORCES RES INST MED SCI,BANGKOK 10400,THAILAND. RP DALSGAARD, A (reprint author), ROYAL VET & AGR UNIV,DEPT VET MICROBIOL,13 BULOWSVEJ,DK-1870 FREDERIKSBERG C,DENMARK. NR 49 TC 80 Z9 84 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD OCT PY 1995 VL 33 IS 10 BP 2715 EP 2722 PG 8 WC Microbiology SC Microbiology GA RV565 UT WOS:A1995RV56500036 PM 8567912 ER PT J AU DAI, WL WOODWARD, PR AF DAI, WL WOODWARD, PR TI A SIMPLE RIEMANN SOLVER AND HIGH-ORDER GODUNOV SCHEMES FOR HYPERBOLIC SYSTEMS OF CONSERVATION-LAWS SO JOURNAL OF COMPUTATIONAL PHYSICS LA English DT Article ID IDEAL MAGNETOHYDRODYNAMICS; EQUATIONS AB A simple approximate Riemann solver for hyperbolic systems of conservation laws is developed for its use in Godunov schemes. The solver is based on characteristic formulations and is illustrated through Euler and ideal magnetohydrodynamical (MHD) equations. The procedure of a high-order Godunov scheme incorporated with the Riemann solver for one-dimensional hyperbolic systems of conservation laws is described in detail. The correctness of the scheme is shown by comparison with the piecewise parabolic method for Euler equations and by comparison with exact solutions of Riemann problems for ideal MHD equations. The robustness of the scheme is demonstrated through numerical examples involving more than one strong shock at the same time. It is shown that the scheme offers the principle advantages of Godunov schemes: robust operation in the presence of strong waves, thin shock fronts, thin contact and slip surface discontinuities. (C) 1995 Academic Press, Inc. RP UNIV MINNESOTA, ARMY HIGH PERFORMANCE COMP RES CTR, INST SUPERCOMP, SCH PHYS & ASTRON, MINNEAPOLIS, MN 55415 USA. NR 24 TC 51 Z9 55 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0021-9991 EI 1090-2716 J9 J COMPUT PHYS JI J. Comput. Phys. PD OCT 1 PY 1995 VL 121 IS 1 BP 51 EP 65 DI 10.1006/jcph.1995.1178 PG 15 WC Computer Science, Interdisciplinary Applications; Physics, Mathematical SC Computer Science; Physics GA RW886 UT WOS:A1995RW88600003 ER PT J AU EAST, EW ROESSLER, T LUSTIG, M AF EAST, EW ROESSLER, T LUSTIG, M TI IMPROVING THE DESIGN-REVIEW PROCESS - THE REVIEWERS ASSISTANT SO JOURNAL OF COMPUTING IN CIVIL ENGINEERING LA English DT Article AB Organizations using architect/engineer (A/E) services typically require reviews of partially completed designs prior to submission of the final design. Many A/E firms also conduct internal quality-control reviews. The objective of these reviews is to increase the cost-effectiveness, timeliness, and overall quality of the completed construction project. Including all project stakeholders in these design reviews is crucial. This paper reports the results of an analysis of the design-review process and the development of a tool to assist design reviewers. The tool, called the Reviewer's Assistant, assists reviewers by capturing, storing, and retrieving design-review comments, and compiling lessons learned. The storage of comments and compilation of lessons learned enable future reviewers to benefit from the experience gained on past reviews of similar projects. C1 USA,CORPS ENGINEERS,ROCKY MT AREA OFF,COLORADO SPRINGS,CO 80909. GIERCZYK INC,HARVEY,IL 60427. RP EAST, EW (reprint author), USA,CORPS ENGINEERS,CONSTRUCT ENGN RES LAB,POB 9005,CHAMPAIGN,IL 61826, USA. NR 11 TC 4 Z9 4 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0887-3801 J9 J COMPUT CIVIL ENG JI J. Comput. Civil. Eng. PD OCT PY 1995 VL 9 IS 4 BP 229 EP 235 DI 10.1061/(ASCE)0887-3801(1995)9:4(229) PG 7 WC Computer Science, Interdisciplinary Applications; Engineering, Civil SC Computer Science; Engineering GA RW060 UT WOS:A1995RW06000002 ER PT J AU MORRISON, EE EBELING, RM AF MORRISON, EE EBELING, RM TI COMPUTATION OF DYNAMIC PASSIVE EARTH PRESSURE USING LISP SO JOURNAL OF COMPUTING IN CIVIL ENGINEERING LA English DT Article AB Few solution techniques exist for the determination of dynamic passive earth pressures for cohesionless soils. The pseudostatic dynamic Mononobe-Okabe equation is widely used to design structures that must resist earthquake loads. Researchers have noted that the Mononobe-Okabe equation assumes a planar failure surface, which is nor the most critical mode of failure for determining the passive failure load. The goal of this research was to develop a more accurate method for computing pseudostatic dynamic passive earth pressures. This paper outlines the development of a computer-program-based solution assuming a log-spiral failure surface to compute pseudostatic dynamic passive earth pressure coefficients. The programming language COMMON LISP was used to develop the code. The features and capabilities of this programming language are not widely known outside the field of computer science. This paper illustrates the use of COMMON LISP in the formulation and solution of computationally intensive algorithms. RP MORRISON, EE (reprint author), USA,WATERWAYS EXPT STN,CEWES IM DS,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 16 TC 0 Z9 0 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0887-3801 J9 J COMPUT CIVIL ENG JI J. Comput. Civil. Eng. PD OCT PY 1995 VL 9 IS 4 BP 285 EP 291 DI 10.1061/(ASCE)0887-3801(1995)9:4(285) PG 7 WC Computer Science, Interdisciplinary Applications; Engineering, Civil SC Computer Science; Engineering GA RW060 UT WOS:A1995RW06000010 ER PT J AU SAU, P GRAHAM, JH HELWIG, EB AF SAU, P GRAHAM, JH HELWIG, EB TI PROLIFERATING EPITHELIAL CYSTS - CLINICOPATHOLOGICAL ANALYSIS OF 96 CASES SO JOURNAL OF CUTANEOUS PATHOLOGY LA English DT Article ID TRICHILEMMAL CYST; CELL-CARCINOMA; PILAR TUMORS; DNA CONTENT; SCALP AB Ninety-six proliferating cutaneous epithelial cysts were classified into two subtypes, proliferating trichilemmal cysts (PTC) and proliferating epidermoid cysts (PEG), depending on the mode of keratinization or the origin of the tumors. The clinicopathological features and the biological behavior of these two subtypes were compared, Among 63 patients with PTC, 45 (71%) were women and 18 (29%) were men. The most common site was the scalp (78%), followed by the trunk (13%), These tumors were well circumscribed subepidermal lesions and demonstrated uniform histologic pattern with varying degrees of cytologic atypia, A few tumors extended into the epidermis and occasionally became ulcerated. Followup of 9 (94%) PTC for an average of 4 years revealed recurrence in one. Tell tumors demonstrated carcinomatous changes including one with anaplastic carcinoma and regional lymph node metastasis. None of these tumors recurred or developed further metastasis following wide excision, Of 33 PECs, 12 (36%) occurred in women and 21 (64%) in men. These tumors were widely distributed in the pelvic and anogenital areas (36%),followed by the scalp (21%), upper extremities (18%), and trunk (15%). Seventy-nine percent of the PECs were located in areas outside the scalp. The PECs were subepidermal tumors but often communicated to the surface, The histologic pattern of PEC was more variable than that of PTC, Seven tumors exhibited carcinomatous changes. Follow-up of 30 (91%) PEC revealed local recurrences in 6, with multiple recurrences in 3, and extensive local invasion in 2, resulting in death in one. Greater anaplasia, high mitotic rate and deeper invasion were associated with increased incidence of recurrence and aggressive behavior. Although both PTC and PEC were locally aggressive tumors and potentially malignant, distant metastasis was unusual. These tumors should he treated with wide local excision, especially those showing cytologic atypia and carcinomatous changes. C1 ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. GRAHAMS DERMATOL SERV,ATLANTIC BEACH,NC. RP SAU, P (reprint author), WALTER REED ARMY MED CTR,DEPT DERMATOL & PATHOL,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 39 TC 52 Z9 55 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0303-6987 J9 J CUTAN PATHOL JI J. Cutan. Pathol. PD OCT PY 1995 VL 22 IS 5 BP 394 EP 406 DI 10.1111/j.1600-0560.1995.tb00754.x PG 13 WC Dermatology; Pathology SC Dermatology; Pathology GA TD492 UT WOS:A1995TD49200002 PM 8594071 ER PT J AU BERGER, RC STOCKSTILL, RL AF BERGER, RC STOCKSTILL, RL TI FINITE-ELEMENT MODEL FOR HIGH-VELOCITY CHANNELS SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Article ID DISSIPATIVE GALERKIN SCHEME; EQUATIONS; FLOW AB Numerical modelers of high-velocity channels are faced with supercritical transitions and the difficulty in capturing discontinuities in the flow field, known as hydraulic jumps. The implied smoothness of a numerical scheme can produce fictitious oscillations near these jump locations and can lead to instability. It is also important that the discrete numerical operations preserve the Rankine-Hugoniot conditions and accurately model jump speed and location. The geometric complexity of high-velocity channels with bridge piers and service ramps are easily represented using an unstructured model. A two-dimensional finite-element model that utilizes a characteristic based Petrov-Galerkin method and a shock-detection mechanism, which relies on elemental energy variation results in a robust system to model high-velocity channels. Comparisons are made between analytic shock-speed results, published laboratory data of a lateral contraction, and with a more general physical model. C1 USA,ENGINEER WATERWAYS EXPT STN,CEWES HW S,VICKSBURG,MS 39180. RP BERGER, RC (reprint author), USA,ENGINEER WATERWAYS EXPT STN,CEWES HW,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 24 TC 49 Z9 49 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD OCT PY 1995 VL 121 IS 10 BP 710 EP 716 DI 10.1061/(ASCE)0733-9429(1995)121:10(710) PG 7 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA RW509 UT WOS:A1995RW50900004 ER PT J AU CLAYSON, ET MYINT, KSA SNITBHAN, R VAUGHN, DW INNIS, BL CHAN, L CHEUNG, P SHRESTHA, MP AF CLAYSON, ET MYINT, KSA SNITBHAN, R VAUGHN, DW INNIS, BL CHAN, L CHEUNG, P SHRESTHA, MP TI VIREMIA, FECAL SHEDDING, AND IGM AND IGG RESPONSES IN PATIENTS WITH HEPATITIS-E SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID NON-B HEPATITIS; LINKED-IMMUNOSORBENT-ASSAY; E VIRUS-INFECTION; EPIDEMIC NON-A; MACACA-FASCICULARIS; VIRAL-HEPATITIS; TRANSMISSION; IDENTIFICATION; EXCRETION; OUTBREAK AB Viremia, fecal shedding and antibody responses to hepatitis E virus (HEV) infections are poorly understood. To better characterize HEV infections, these responses were examined in 67 patients with acute markers for hepatitis E who were admitted to the Infectious Disease Hospital in Kathmandu, Nepal in 1993. A single stool and multiple sera from each patient were examined using polymerase chain reaction to detect HEV RNA. Sera were also examined for antibodies to HEV. Viremia, fecal shedding, and IgM and IgG to HEV were detected in 93%, 70%, 79%, and 87% of 67 patients, respectively. Viremia or fecal shedding (or both) were detected in 14 patients from whom IgM and IgG to HEV were not detected. Viremia lasted at least 2 weeks in nearly all subjects and at least 39 days in 1 subject. Our results suggest that viremia is a common occurrence in patients infected with HEV. C1 WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, WASHINGTON, DC 20307 USA. GENELABS DIAGNOST, SINGAPORE, SINGAPORE. INFECT DIS HOSP, KATMANDU, NEPAL. USA MED COMPONENT, ARMED FORCES RES INST MED SCI, DEPT VIROL, BANGKOK 10400, THAILAND. NR 48 TC 114 Z9 119 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD OCT PY 1995 VL 172 IS 4 BP 927 EP 933 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA RW062 UT WOS:A1995RW06200002 PM 7561211 ER PT J AU KRAKAUER, T AF KRAKAUER, T TI INHIBITION OF TOXIC SHOCK SYNDROME TOXIN-1-INDUCED CYTOKINE PRODUCTION AND T-CELL ACTIVATION BY INTERLEUKIN-10, INTERLEUKIN-4, AND DEXAMETHASONE SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID HUMAN-MONOCYTES; IFN-GAMMA; SUPERANTIGENS; INTERFERON; RECEPTORS; ANTIGEN; IL-1 AB Toxic shock syndrome toxin-1 (TSST-1) induced production of the cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1, IL-6, IL-2, and interferon-gamma (IFN-gamma) by human peripheral blood mononuclear cells (PBMC). In contrast, only low levels of IL-10 were present and IL-4 was absent in TSST-1-stimulated PBMC. Addition of IL-10 to TSST-1-stimulated PBMC inhibited the production of TNF-alpha, IL-1, IL-6, and IFN-gamma by 68%, 93%, 70%, and 86%, respectively, but had less effect (14%-37%) on T cell proliferation. IL-4 was less effective than IL-10 in inhibiting cytokine production and had no effect on T cell proliferation induced by TSST-1. Dexamethasone, an antiinflammatory agent, was the most potent agent in controlling TSST-1-mediated effects, as evidenced by inhibited T cell proliferation (>74%), reduced levels of cytokines (70%-84%), and reduced expression of CD25 and CD69 on PBMC. Thus, dexamethasone may be a useful agent to mitigate TSST-1-mediated toxic shock. RP KRAKAUER, T (reprint author), USA,MED RES INST INFECT DIS,DIV APPL RES,BLDG 1425,FREDERICK,MD 21702, USA. NR 28 TC 44 Z9 46 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD OCT PY 1995 VL 172 IS 4 BP 988 EP 992 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA RW062 UT WOS:A1995RW06200011 PM 7561220 ER PT J AU BROWN, AE VAHEY, MT ZHOU, SYJ CHUNG, RCY RUIZ, NM HOFHEINZ, D LANE, JR MAYERS, DL WAGNER, K FUJIMARAJUSTICE, M KERNOZEK, P KOCH, K BREWER, C CHUNG, R SHELLIE, E LORIZLIM, L SMALLS, C HAMILTON, A BURKE, DS ROBERTS, CR ABRAMS, L MANSFIELD, J PEARSON, D WEISLOW, O FOWLER, A MERRITT, L AF BROWN, AE VAHEY, MT ZHOU, SYJ CHUNG, RCY RUIZ, NM HOFHEINZ, D LANE, JR MAYERS, DL WAGNER, K FUJIMARAJUSTICE, M KERNOZEK, P KOCH, K BREWER, C CHUNG, R SHELLIE, E LORIZLIM, L SMALLS, C HAMILTON, A BURKE, DS ROBERTS, CR ABRAMS, L MANSFIELD, J PEARSON, D WEISLOW, O FOWLER, A MERRITT, L TI QUANTITATIVE RELATIONSHIP OF CIRCULATING P24 ANTIGEN WITH HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) RNA AND SPECIFIC ANTIBODY IN HIV-INFECTED SUBJECTS RECEIVING ANTIRETROVIRAL THERAPY SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note ID CAPTURE ASSAY; PLASMA AB To better understand the biologic meaning and potential clinical utility of p24 antigen measurements in human immunodeficiency virus (HIV) infection, p24 antigen and antibody and HIV RNA were quantitated in parallel, Specimens (n = 311) were analyzed from 74 participants in a zidovudine treatment study, Parallel antigen and RNA measurements revealed the frequent occurrence of two types of discordant results, First, p24 antigen was often not detected in samples with high antibody levels even when >10(6) RNA copies/mL were present, Second, in specimens in which p24 antigen was detected, the concentration was greater than expected on the basis of HIV RNA values, These results suggest that optimal use of serum p24 antigen values will require consideration of both specific antibody levels and non-virion associated antigen. C1 SRA TECHNOL, ROCKVILLE, MD USA. NATL NAVAL MED CTR, BETHESDA, MD USA. WALTER REED ARMY MED CTR, WASHINGTON, DC USA. COULTER IMMUNOL, HIALEAH, FL USA. RP BROWN, AE (reprint author), HENRY M JACKSON FDN ADVANCEMENT MIL RES, WALTER REED ARMY INST RES, SUITE 201, 13 TAFT CT, ROCKVILLE, MD 20850 USA. NR 15 TC 18 Z9 18 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD OCT PY 1995 VL 172 IS 4 BP 1091 EP 1095 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA RW062 UT WOS:A1995RW06200027 PM 7561186 ER PT J AU KENNER, JR COSTER, TS TAYLOR, DN TROFA, AF BARRERAORO, M HYMAN, T ADAMS, JM BEATTIE, DT KILLEEN, KP SPRIGGS, DR MEKALANOS, JJ SADOFF, JC AF KENNER, JR COSTER, TS TAYLOR, DN TROFA, AF BARRERAORO, M HYMAN, T ADAMS, JM BEATTIE, DT KILLEEN, KP SPRIGGS, DR MEKALANOS, JJ SADOFF, JC TI PERU-15, AN IMPROVED LIVE ATTENUATED ORAL VACCINE CANDIDATE FOR VIBRIO-CHOLERAE-01 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note ID BANGLADESH AB Cholera vaccine candidate Peru-15 was derived from a Vibrio cholerae O1 El Tor Inaba strain by deleting the cholera toxin genetic element, introducing the gene encoding cholera toxin B subunit into recA, and screening for nonmotility. In a controlled study, Peru-15 (2 x 10(8) cfu) was administered to 11 volunteers. No vaccinee developed diarrhea, and 10 of 11 had >4-fold rises in vibriocidal antibody titers. One month later, 5 vaccinees and 5 control volunteers were challenged with wild type V. cholerae O1. Four of 5 controls developed diarrhea (mean, 1.9 L). Two Peru-15 vaccinees developed diarrhea, 1 with <0.3 L and 1 with similar to 1.0 L; this latter volunteer had not developed a significant vibriocidal immune response to vaccination. Peru-15 shows promise as a single-dose, oral cholera vaccine that is safe, immunogenic, and protective. C1 USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. INST VIRUS RES,CAMBRIDGE,MA. HARVARD UNIV,SCH MED,DEPT MICROBIOL & MOLEC GENET,BOSTON,MA 02115. NR 14 TC 84 Z9 92 U1 0 U2 4 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD OCT PY 1995 VL 172 IS 4 BP 1126 EP 1129 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA RW062 UT WOS:A1995RW06200036 PM 7561195 ER PT J AU EBERSOLE, D MILLER, L BAILEY, SR AF EBERSOLE, D MILLER, L BAILEY, SR TI CORONARY-ARTERY STENTING IN ACTIVE-DUTY SOLDIERS SO JOURNAL OF INVASIVE CARDIOLOGY LA English DT Article DE ANGIOPLASTY; INTRACORONARY STENTING; YOUNG AB The treatment of coronary artery disease in young patients must take into account the long-term success of the treatment modality and the possibility of repeat interventions. Elective placement of Palmaz-Schatz coronary stents have been shown to reduce six month restenosis rates in discrete, de novo lesions in native coronary arteries albeit at a significant risk of bleeding and vascular complications. The present study was undertaken to evaluate the role of intracoronary stenting in young active duty soldiers. Between March 1988 and December 1994, fifteen active duty soldiers (age 37 to 53 years) underwent elective placement of one or more Palmaz-Schatz coronary stents at our institution. Angiographic success was 100% with no complications (acute/subacute closure, bleeding requiring transfusion, vascular repair, myocardial infarction, death, or in-hospital coronary artery bypass grafting). Six month angiographic follow-up is available in 13 patients (87%) with angiographic restenosis in one patient (8%) and no target vessel revascularization at six months. Clinical follow-up is available on all patients at a mean of 33 months (range 6-65) after the procedure. There was one death (7%) attributed to progression of coronary disease in another vessel and one patient (7%) who underwent target vessel revascularization for silent ischemia at 24 months after the procedure. These preliminary encouraging results suggest there may be a significant role for intracoronary stenting in active duty soldiers with coronary artery disease. RP EBERSOLE, D (reprint author), BROOKE ARMY MED CTR,DEPT MED,SERV CARDIOL,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU HEALTH MANAGEMENT PUBLICATIONSINC PI WAYNE PA 950 WEST VALLEY RD, STE 2800, WAYNE, PA 19087 SN 1042-3931 J9 J INVASIVE CARDIOL JI J. Invasive Cardiol. PD OCT PY 1995 VL 7 IS 8 BP 233 EP 237 PG 5 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA TA544 UT WOS:A1995TA54400004 PM 10158114 ER PT J AU TANG, TL KIANG, JG COTE, T COX, BM AF TANG, TL KIANG, JG COTE, T COX, BM TI OPIOID-INDUCED INCREASE IN [CA2+](I) IN ND8-47 NEUROBLASTOMA X DORSAL-ROOT GANGLION HYBRID-CELLS IS MEDIATED THROUGH G-PROTEIN-COUPLED DELTA-OPIOID RECEPTORS AND DESENSITIZED BY CHRONIC EXPOSURE TO OPIOID SO JOURNAL OF NEUROCHEMISTRY LA English DT Article DE OPIOID RECEPTOR; INTRACELLULAR FREE CALCIUM; GTP-BINDING PROTEIN; NEUROBLASTOMA X DORSAL ROOT GANGLION NEURON HYBRID; CELL LINE; ND8-47; PERTUSSIS TOXIN ID NUCLEOTIDE-BINDING PROTEIN; NEURONAL CALCIUM CHANNELS; ADENYLATE-CYCLASE; SENSORY NEURONS; INDUCED STIMULATION; OPIATE RECEPTORS; DOWN-REGULATION; NG108-15 CELLS; INHIBITION; MU AB delta-Receptor agonists induce a concentration-dependent increase in intracellular calcium concentration ([Ca2+]i) in ND8-47 cells by activating dihydropyridine-sensitive Ca2+ channels. The role of G proteins in transducing the opioid effect has been studied. Pretreatment of cells with pertussis toxin (100 ng/ml, 24 h) almost completely blocked [D-Ser(2),Leu(5)] enkephalin-Thr (DSLET)-induced increase in [Ca2+]i. Cholera toxin (10 nM, 24 h) had no effect on DSLET-induced response. Pretreatment of the cells with 1 mu M DSLET for 1 h resulted in a 30% inhibition of DSLET-induced increase in [Ca2+]i and a 78% inhibition after exposure for 24 h. After 1 h of exposure to DSLET, there was a decrease in agonist affinity with no significant changes in receptor density. Cells exposed to 1 mu M DSLET for 24 h demonstrate a nearly 90% decrease in [H-3]diprenorphine binding, with a decrease in affinity for agonist at the remaining binding sites. G protein subunits alpha(1)2, alpha(1)3, alpha(s), and alpha(q) were detected in ND8-47 cell membranes by western blot; alpha(0) and alpha(1)1 were not present. Chronic DSLET treatment had no significant effect on the quantity of each of the alpha-subunits. These results suggest that the DSLET-induced increase in [Ca2+]i is mediated through pertussis toxin-sensitive G proteins (probably G(i2) or G(i3)) and the attenuation of this response in chronically treated cells is associated with a relatively rapid reduction in receptor affinity to DSLET and a dow reduction in receptor density. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PHARMACOL,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV MED,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307. FU NIDA NIH HHS [DA 03102] NR 52 TC 16 Z9 17 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0022-3042 J9 J NEUROCHEM JI J. Neurochem. PD OCT PY 1995 VL 65 IS 4 BP 1612 EP 1621 PG 10 WC Biochemistry & Molecular Biology; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA RW335 UT WOS:A1995RW33500021 PM 7561856 ER PT J AU CARAVALHO, J BALINGIT, AG RIVERARODRIGUEZ, JE SHRIVER, CD KOOPS, MK AF CARAVALHO, J BALINGIT, AG RIVERARODRIGUEZ, JE SHRIVER, CD KOOPS, MK TI LOCALIZATION OF AN ECTOPIC PARATHYROID ADENOMA BY DOUBLE-PHASE TECHNETIUM-99M-SESTAMIBI SCINTIGRAPHY SO JOURNAL OF NUCLEAR MEDICINE LA English DT Note DE PARATHYROID GLAND; HYPERPARATHYROIDISM; ECTOPIC PARATHYROID ADENOMA AB Double-phase planar scintigraphy using Tc-99m-MIBI has been introduced as a means to detect and localize parathyroid adenomas. Focal uptake on both early and delayed imaging is typical of these entities. We report a patient with persistent hypercalcemia following subtotal parathyroidectomy, who was found scintigraphically to have an ectopic parathyroid adenoma. Following initial detection within the mediastinum using planar scintigraphy, the adenoma was more precisely localized using SPECT imaging. This case suggests that double-phase parathyroid planar scintigraphy augmented with SPECT imaging, if needed, is cost-effective, and often necessary, in the assessment of primary hyperparathyroid patients before surgical reexploration. C1 WALTER REED ARMY MED CTR,DEPT RADIOL,NUCL MED SERV,SURG ONCOL & ENDOCRINE & METAB DIS SERV,WASHINGTON,DC 20307. NR 9 TC 19 Z9 20 U1 0 U2 0 PU SOC NUCLEAR MEDICINE INC PI RESTON PA 1850 SAMUEL MORSE DR, RESTON, VA 22090-5316 SN 0161-5505 J9 J NUCL MED JI J. Nucl. Med. PD OCT PY 1995 VL 36 IS 10 BP 1840 EP 1842 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA RZ318 UT WOS:A1995RZ31800027 PM 7562052 ER PT J AU LOUBE, DI STROLLO, PJ EPSTEIN, LJ DAVENPORT, WL AF LOUBE, DI STROLLO, PJ EPSTEIN, LJ DAVENPORT, WL TI THE EFFECT OF QUIET TIDAL BREATHING ON LATERAL CEPHALOMETRIC MEASUREMENTS SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article ID OBSTRUCTIVE SLEEP-APNEA; UPPER AIRWAY; UVULOPALATOPHARYNGOPLASTY AB Purpose: In the evaluation of the upper airway in patients with sleep apnea it has been suggested that cephalometric radiographs be performed at either end-inspiration or end-expiration during quiet tidal breathing, This study sought to determine if standard soft tissue cephalometric measurements vary significantly with tidal breathing, Patients and Methods: In this prospective, controlled study 22 adult male patients with the sleep apnea/hypopnea syndrome and 27 nonapneic, nonsnoring male controls had cephalometric radiographs performed at end-tidal inspiration and end-tidal expiration. The measurements obtained from each radiograph included the posterior airway space distance, the mandibular plane to hyoid distance, and the posterior nasal spine to tip of palate (PNS-P) distance, Results: There were no statistically significant differences between the inspiratory and expiratory measurements in either group, Only the PNS-P distance differed significantly between the two groups, Changes in cephalometric measurements did not occur uniformly in any one direction with tidal breathing, Conclusion: The data indicate that coordinating radiographic exposure to respiratory cycle phase is not necessary for soft-tissue measurements commonly used to assess upper airway patency in patients with the sleep apnea/hypopnea syndrome. C1 BROOKE ARMY MED CTR,DEPT MED,FT SAM HOUSTON,TX 78234. UNIV PITTSBURGH,DEPT PULM ALLERGY & CRIT CARE MED,PITTSBURGH,PA. WILFORD HALL USAF MED CTR,DEPT MED,CTR SLEEP DISORDERS,LACKLAND AFB,TX 78236. WILFORD HALL USAF MED CTR,DEPT ORAL & MAXILLOFACIAL SURG,LACKLAND AFB,TX 78236. NR 20 TC 3 Z9 4 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD OCT PY 1995 VL 53 IS 10 BP 1155 EP 1159 DI 10.1016/0278-2391(95)90623-1 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA RX416 UT WOS:A1995RX41600007 PM 7562168 ER PT J AU Zimmerman, PA Francis, GL AF Zimmerman, PA Francis, GL TI A possible new syndrome of familial euthyroid dysproteinemia associated with elevated thyroxine and triiodothyronine SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM LA English DT Article ID DYSALBUMINEMIC HYPERTHYROXINEMIA; BINDING-PROTEINS; AFFINITY; ABNORMALITIES; PREALBUMIN; VARIANT AB Increased thyroxine (T-4) binding to thyroid binding prealbumin (TBPA) or albumin causes a biochemical picture suggestive of thyrotoxicosis with increased total T-4 (TT4). Previously described familial syndromes are characterized by increased binding of T-4 to thyroid binding globulin (TBG), TBPA, or albumin, Increased T-3 binding to TBG has been noted, but we are not aware of any kindreds reported with increased T-3 binding to TBPA or albumin, We wish to report a family in which there is increased binding of T-3 to TBG, TBPA and albumin, All family members were clinically euthyroid and tested negative for T-3 antibodies, This family appears to demonstrate two abnormalities: first, elevated TBG, and second, normal levels of TBPA and albumin with increased binding of T-3 and T-4 to these proteins, We believe this may represent a new syndrome of familial dysproteinemia in which multiple proteins show enhanced binding of T-3 and T-4. This could reflect increased binding sites, increased binding affinity, or a combination of both. C1 WALTER REED ARMY MED CTR,DEPT PEDIAT ENDOCRINOL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT,BETHESDA,MD 20814. NR 15 TC 0 Z9 0 U1 0 U2 0 PU FREUND PUBLISHING HOUSE PI LONDON PA STE 500, CHESHAM HOUSE, 150 REGENT ST, LONDON, ENGLAND W1R 5FA SN 0334-018X J9 J PEDIATR ENDOCR MET JI J. Pediatr. Endocrinol. Metab. PD OCT-DEC PY 1995 VL 8 IS 4 BP 253 EP 256 PG 4 WC Endocrinology & Metabolism; Pediatrics SC Endocrinology & Metabolism; Pediatrics GA TP537 UT WOS:A1995TP53700003 PM 8821901 ER PT J AU RAMOS, V GIEBINK, DL FISHER, JG CHRISTENSEN, LC AF RAMOS, V GIEBINK, DL FISHER, JG CHRISTENSEN, LC TI COMPLETE DENTURES FOR A CHILD WITH HYPOHIDROTIC ECTODERMAL DYSPLASIA - A CLINICAL REPORT SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article C1 WALTER REED ARMY MED CTR,PROSTHODONT DENT RESIDENCY PROGRAM,WASHINGTON,DC. WALTER REED ARMY MED CTR,FT GEORGE G MEADE,MD. PEDIAT DENT RESIDENCY PROGRAM,FT GEORGE G MEADE,MD. NR 5 TC 12 Z9 13 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD OCT PY 1995 VL 74 IS 4 BP 329 EP 331 DI 10.1016/S0022-3913(05)80369-5 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA TB895 UT WOS:A1995TB89500001 PM 8531147 ER PT J AU REYNOLDS, K DARRIGRAND, A ROBERTS, D KNAPIK, J POLLARD, J DUPLANTIS, K JONES, B AF REYNOLDS, K DARRIGRAND, A ROBERTS, D KNAPIK, J POLLARD, J DUPLANTIS, K JONES, B TI EFFECTS OF AN ANTIPERSPIRANT WITH EMOLLIENTS ON FOOT-SWEAT ACCUMULATION AND BLISTER FORMATION WHILE WALKING IN THE HEAT SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article AB Background: Friction blisters are a common injury in sports activities and military operations, Blisters can compromise performance, so it is important to devise preventive strategies to reduce these injuries. Objective: This study investigated the influence of an antiperspirant with emollient additives on frequency and severity of friction blisters, hot spots, and irritant dermatitis. Methods: Twenty-three healthy men walked on a treadmill (1.39 m/sec, 1% grade) in a warm environment (28 degrees C, 25% relative humidity) carrying a total mass of 21 +/- 1 kg. For 4 consecutive days before the walk, the subjects' feet were treated with either (1) an antiperspirant (20% aluminum zirconium tetrachlorohydrex glycine concentration plus water) with emollient additives, (2) emollient additives alone (placebo control), or (3) nothing (nontreated). In two separate trials (1 month apart) each participant received the antiperspirant treatment and both control treatments (emollient [placebo] and no treatment). Results: No differences were seen among treatment conditions for swear accumulation (p = 0.86), blister incidence (p = 0.36), hot spot incidence (p = 0.83), or blister severity (p = 0.31). Irritant dermatitis was not reported in any of the treatment conditions. Conclusion: The use of an antiperspirant with emollients reduces irritant dermatitis but does not reduce total foot-sweat accumulation, blister or hot spot incidence, or blister severity. RP REYNOLDS, K (reprint author), USA,ENVIRONM MED RES INST,DIV OCCUPAT MED,NATICK,MA 01760, USA. NR 21 TC 22 Z9 22 U1 0 U2 3 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD OCT PY 1995 VL 33 IS 4 BP 626 EP 630 DI 10.1016/0190-9622(95)91283-5 PG 5 WC Dermatology SC Dermatology GA RX311 UT WOS:A1995RX31100011 PM 7673497 ER PT J AU Rutkowski, MJ Ruzicka, GC Ormiston, RA Saberi, H Jung, Y AF Rutkowski, MJ Ruzicka, GC Ormiston, RA Saberi, H Jung, Y TI Comprehensive aeromechanics analysis of complex rotorcraft using 2GCHAS SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB 2GCHAS is a comprehensive, multi-disciplinary, computer software system for predicting rotorcraft aeromechanics characteristics, It is a finite element based system with a variety of aerodynamic modeling options and provides modeling and analysis flexibility, prediction accuracy, and user-friendly input and output, The software is maintainable, expandable, and transportable to various computer platforms. The paper briefly describes the development of the System and key features for modeling complex rotorcraft, A series of rotorcraft analysis problems is presented to illustrate the range of capabilities available, including single and tandem rotor helicopters with engine/drive trains and feedback flight control systems, Various aerodynamic airloads, rotor wake, and component interference models are used in calculating performance, flight dynamic response, rotor loads and vibrations, and aeroelastic stability. C1 ADV ROTORCRAFT TECHNOL INC,MT VIEW,CA. RP Rutkowski, MJ (reprint author), USA,AVIAT & TROP COMMAND,AMES RES CTR,AEROFLIGHTDYNAM DIRECTORATE,DIV ROTORCRAFT DYNAM,MOFFETT FIELD,CA 94035, USA. NR 20 TC 9 Z9 9 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD OCT PY 1995 VL 40 IS 4 BP 3 EP 17 PG 15 WC Engineering, Aerospace SC Engineering GA TM061 UT WOS:A1995TM06100001 ER PT J AU Duyar, A Gu, Z Litt, JS AF Duyar, A Gu, Z Litt, JS TI A simplified dynamic model of the T700 turboshaft engine SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB A simplified open-loop dynamic model of the T700 turboshaft engine, valid within the normal operating range df the engine, is developed. This model is obtained by linking linear state space models determined at different engine operating points. Each linear model is developed from a detailed nonlinear engine simulation using a multivariable system identification and realization method. The simplified model may be used with a model-based real time diagnostic scheme for fault detection and diagnostics, as well as for open loop engine dynamics studies and closed loop control analysis utilizing a user generated control law. C1 LEWIS RES CTR,US ARMY AVIAT SYST COMMAND,PROPULS DIRECTORATE,CLEVELAND,OH. RP Duyar, A (reprint author), FLORIDA ATLANTIC UNIV,DEPT MECH ENGN,BOCA RATON,FL 33431, USA. NR 16 TC 7 Z9 8 U1 0 U2 2 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD OCT PY 1995 VL 40 IS 4 BP 62 EP 70 PG 9 WC Engineering, Aerospace SC Engineering GA TM061 UT WOS:A1995TM06100005 ER PT J AU MAIT, JN AF MAIT, JN TI UNDERSTANDING DIFFRACTIVE OPTIC DESIGN IN THE SCALAR DOMAIN SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID BINARY PHASE GRATINGS; PATTERN RECOGNITION; IMAGE-RECONSTRUCTION; FILTERS; EFFICIENCY; ELEMENTS; HOLOGRAMS; ALGORITHM AB A general procedure is presented for the design of diffractive optical elements, and scalar diffraction theory is used to apply it to the design of three common diffractive elements: a diffractive lens, an array generator, and a correlation filter. The procedure reveals that most common design techniques can be classified as either direct or indirect optimizations. The key feature of the design procedure is the specification of a suitable performance measure based on the designer's understanding of the optical system and the fabrication technology used to realize the diffractive element. The use of complex-wave amplitude, scale, and phase freedoms in design is also emphasized. (C) 1995 Optical Society of America RP MAIT, JN (reprint author), USA,RES LAB,AMSRL SE EO,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 43 TC 103 Z9 103 U1 1 U2 7 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0740-3232 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD OCT PY 1995 VL 12 IS 10 BP 2145 EP 2158 DI 10.1364/JOSAA.12.002145 PG 14 WC Optics SC Optics GA RW333 UT WOS:A1995RW33300008 ER PT J AU ANDREWS, LC MILLER, WB AF ANDREWS, LC MILLER, WB TI SINGLE-PASS AND DOUBLE-PASS PROPAGATION THROUGH COMPLEX PARAXIAL OPTICAL-SYSTEMS (VOL 12, PG 137, 1995) SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Correction, Addition C1 UNIV CENT FLORIDA,CTR RES & EDUC OPT & LASERS,ORLANDO,FL 32816. USA,RES LAB,BATTLEFIELD ENVIRONM DIRECTORATE,WHITE SANDS MISSILE RANGE,NM 88002. RP ANDREWS, LC (reprint author), UNIV CENT FLORIDA,DEPT MATH,ORLANDO,FL 32816, USA. NR 1 TC 1 Z9 1 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0740-3232 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD OCT PY 1995 VL 12 IS 10 BP 2213 EP 2213 DI 10.1364/JOSAA.12.002213 PG 1 WC Optics SC Optics GA RW333 UT WOS:A1995RW33300016 ER PT J AU STEPHENSON, LA KOLKA, MA AF STEPHENSON, LA KOLKA, MA TI INCREASED SKIN BLOOD-FLOW AND ENHANCED SENSIBLE HEAT-LOSS IN HUMANS AFTER NICOTINIC-ACID INGESTION SO JOURNAL OF THERMAL BIOLOGY LA English DT Article DE BODY TEMPERATURE; EXERCISE; THERMOREGULATION; SKIN BLOOD FLOW; CLOTHING; NIACIN; SWEATING RATE; CUTANEOUS VASCULAR CONDUCTANCE; DIURNAL VARIATION ID CUTANEOUS VASCULAR-RESPONSES; CIRCADIAN VARIATION; SMOOTH-MUSCLE; EXERCISE; VASODILATION; PROSTACYCLIN; TEMPERATURE; STRESS; YOUNG; MEN AB 1. A series of studies was conducted to characterize thermal and cardiovascular responses to nicotinic acid (NA) ingestion (5 mg . kg(-1)) in healthy subjects: (a) at rest, seated (T-a = 30 degrees C, RH = 23%) at 0800 h and again between 1800 and 2100 h; (b) at rest and during seated exercise (T-a = 29 degrees C, RH = 30%); and (c) during upright exercise when wearing a protective clothing system (T-a = 28 degrees C, RH = 30%). 2. (a) NA ingestion decreased esophageal (T-es) and arterial pressure and increased mean skin temperature ((T) over bar(sk)), skin blood flow (SkBF), forearm blood flow (FBF), heart rate, and cutaneous vascular conductance (P < 0.05) in the morning and evening. In the evening 2/4 subjects experienced substantial hypotension. (b) At rest, peak SkBF and peak FBF were 600% higher in NA than control while T-es was 0.6 degrees C lower and (T) over bar(sk), was 0.6 degrees C higher after NA (P < 0.05). During seated exercise, SkBF and FBF were 30% higher and T-es was 0.3 degrees C lower after NA than control (P < 0.05). (c) During upright exercise, NA increased SkBF in subjects clothed in protective clothing. 3. Vascular responsiveness to NA was enhanced in the evening as shown by the increased hypotensive effect of NA in the evening. NA ingestion effectively increased sensible heat flux during rest, seated exercise and upright exercise. However, manipulation of SkBF by NA ingestion should be done cautiously, especially when NA will be used in novel circumstances. RP STEPHENSON, LA (reprint author), USA,ENVIRONM MED RES INST,DIV THERMAL PHYSIOL & MED,NATICK,MA 01760, USA. NR 52 TC 2 Z9 2 U1 1 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0306-4565 J9 J THERM BIOL JI J. Therm. Biol. PD OCT PY 1995 VL 20 IS 5 BP 409 EP 423 DI 10.1016/0306-4565(94)00078-W PG 15 WC Biology; Zoology SC Life Sciences & Biomedicine - Other Topics; Zoology GA TH120 UT WOS:A1995TH12000007 ER PT J AU BUNDY, ML HORST, AW ROBBINS, FW AF BUNDY, ML HORST, AW ROBBINS, FW TI PROJECTILE FIN DAMAGE FROM PROPELLANT COMBUSTION SO JOURNAL OF THERMOPHYSICS AND HEAT TRANSFER LA English DT Article AB Thermal ablation of anodized (hard coated) aluminum fins on high-velocity, gun-launched kinetic energy penetrators is a serious problem at long ranges. It degrades flight performance by reducing stability and roll. Additionally, uneven ablation creates aerodynamic asymmetries that further increase projectile dispersion. The problem is known to begin in-bore. A fin-testing procedure is used to create in-here heating conditions similar to those of a normal launch, without actually launching the fin. Postfired examination of the fins is then used to ascertain the fin damage mechanism for the nonlaunched fins as well as to infer the fin damage mechanism for normally launched fins. A two-phase flow interior ballistic code is also used to model the fin temperature profile for both the nonlaunch and the normal launch configuration. Qualitative comparison is made between the effects expected from modeling and those actually observed. Experimentally, the nonlaunched fins sustained mostly leading-edge damage, entailing Loss of hard coat followed by the uneven downstream ablation. Modeling appears to underpredict the observed effects, but this is thought to be a consequence of neglecting, a priori, the possibility of rapid fin surface oxidation (burning). RP BUNDY, ML (reprint author), USA,RES LAB,DIV PROP & FLIGHT,ABERDEEN PROVING GROUND,MD 21005, USA. NR 9 TC 1 Z9 1 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0887-8722 J9 J THERMOPHYS HEAT TR JI J. Thermophys. Heat Transf. PD OCT-DEC PY 1995 VL 9 IS 4 BP 784 EP 789 DI 10.2514/3.739 PG 6 WC Thermodynamics; Engineering, Mechanical SC Thermodynamics; Engineering GA TB802 UT WOS:A1995TB80200029 ER PT J AU HOPPEL, CPR BOGETTI, TA GILLESPIE, JW AF HOPPEL, CPR BOGETTI, TA GILLESPIE, JW TI LITERATURE-REVIEW - EFFECTS OF HYDROSTATIC-PRESSURE ON THE MECHANICAL-BEHAVIOR OF COMPOSITE-MATERIALS SO JOURNAL OF THERMOPLASTIC COMPOSITE MATERIALS LA English DT Article DE HYDROSTATIC; PRESSURE; TRIAXIAL; COMPOSITE MATERIALS; COMPRESSION; STRENGTH ID GRAPHITE EPOXY COMPOSITES; METAL MATRIX COMPOSITES; COMPRESSIVE FAILURE; FIBER COMPOSITES; POLYESTER COMPOSITES; TOUGH POLYETHYLENES; FRACTURE-TOUGHNESS; TENSILE PROPERTIES; YIELD CRITERIA; KINKING AB Hydrostatic pressure can cause significant changes in the mechanical properties of composite materials. A thorough understanding of these effects is essential for the effective design of composite structures for high-pressure applications. In this report, the literature on the effects of hydrostatic pressure on the mechanical behavior of composite materials is reviewed. This includes a general description of the effects of hydrostatic pressure on unreinforced polymers and a detailed critique of the experimental work that has been done on composite materials. The section on composites is divided into three sections: compressive, tensile, and shear testing. For each type of testing, the test materials and techniques and the physical and quantitative results are discussed. C1 UNIV DELAWARE, CTR COMPOSITE MAT, NEWARK, DE 19716 USA. USA, RES LAB, WT-PD, ABERDEEN PROVING GROUND, MD 21005 USA. NR 55 TC 25 Z9 25 U1 1 U2 8 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0892-7057 EI 1530-7980 J9 J THERMOPLAST COMPOS JI J. Thermoplast. Compos. Mater. PD OCT PY 1995 VL 8 IS 4 BP 375 EP 409 PG 35 WC Materials Science, Composites SC Materials Science GA RY241 UT WOS:A1995RY24100003 ER PT J AU MOKULIS, JA ARNDT, WF DOWNEY, JR CABALLERO, RL THOMPSON, IM AF MOKULIS, JA ARNDT, WF DOWNEY, JR CABALLERO, RL THOMPSON, IM TI SHOULD RENAL ULTRASOUND BE PERFORMED IN THE PATIENT WITH MICROSCOPIC HEMATURIA AND A NORMAL EXCRETORY UROGRAM SO JOURNAL OF UROLOGY LA English DT Article DE ULTRASONOGRAPHY; HEMATURIA; UROGRAPHY; DIAGNOSTIC IMAGING ID NEOPLASMS AB Purpose: We determine what additional information would be detected by renal ultrasonography that was not identified by a normal excretory urogram (IVP) performed for the evaluation of microscopic hematuria. Materials and Methods: A retrospective review was done of 101 patients with microscopic hematuria and a normal IVP who underwent renal ultrasonography. Results: Of the 101 patients with microscopic hematuria and a normal IVP, renal ultrasonography was abnormal in 20%. All findings were ultimately proved to be of no clinical significance, although 6 of 21 patients required a total of 10 additional studies, including 9 computerized tomography scans and 1 renal arteriogram. Conclusions: These data demonstrate that renal ultrasonography is unnecessary in a patient with microscopic hematuria and a normal IVP. C1 BROOKE ARMY MED CTR,DEPT UROL,SAN ANTONIO,TX. BROOKE ARMY MED CTR,DEPT RADIOL,SAN ANTONIO,TX. RP MOKULIS, JA (reprint author), WILFORD HALL USAF MED CTR,DEPT UROL,SAN ANTONIO,TX 78236, USA. NR 8 TC 3 Z9 3 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD OCT PY 1995 VL 154 IS 4 BP 1300 EP 1301 DI 10.1016/S0022-5347(01)66841-1 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA RU472 UT WOS:A1995RU47200004 PM 7658523 ER PT J AU THOMPSON, IM AF THOMPSON, IM TI NONPALPABLE INTRATESTICULAR MASSES DETECTED SONOGRAPHICALLY - COMMENT SO JOURNAL OF UROLOGY LA English DT Editorial Material RP THOMPSON, IM (reprint author), BROOKE ARMY MED CTR,UROL SERV,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD OCT PY 1995 VL 154 IS 4 BP 1369 EP 1369 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA RU472 UT WOS:A1995RU47200029 ER PT J AU RENFER, LG SCHOW, D THOMPSON, IM OPTENBERG, S AF RENFER, LG SCHOW, D THOMPSON, IM OPTENBERG, S TI IS ULTRASOUND GUIDANCE NECESSARY FOR TRANSRECTAL PROSTATE BIOPSY SO JOURNAL OF UROLOGY LA English DT Article DE PROSTATIC NEOPLASMS; BIOPSY, NEEDLE; ULTRASONOGRAPHY AB Purpose: The relatively simultaneous development of spring-loaded biopsy devices and the proliferation of transrectal ultrasonography for transrectal guidance of biopsy needles have led to the general use of both technologies for transrectal prostate biopsy. This review was done because the incremental cost of ultrasonographic guidance is considerable and the marginal improvement of sensitivity over digital guidance alone is unknown. Materials and Methods: A total of 200 consecutive men underwent prostate biopsy with digital and ultrasound guidance. Results: Biopsy sensitivity was superior for ultrasound guidance in all categories of tumors studied, with an overall sensitivity of 88% compared to 74% for digital guidance. Nevertheless, 12% of the tumors were detected with digital rectal examination guidance alone. Conclusions: These data suggest that the optimal method of prostate biopsy may include ultrasound and digital guidance. C1 USA,MED DEPT CTR & SCH,CTR HLTH CARE STUDIES,FT SAM HOUSTON,TX. RP RENFER, LG (reprint author), BROOKE ARMY MED CTR,UROL SURG SERV,FT SAM HOUSTON,TX 78234, USA. NR 5 TC 14 Z9 14 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD OCT PY 1995 VL 154 IS 4 BP 1390 EP 1391 DI 10.1016/S0022-5347(01)66873-3 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA RU472 UT WOS:A1995RU47200036 PM 7658544 ER PT J AU CHU, YK JENNINGS, GB SCHMALJOHN, CS AF CHU, YK JENNINGS, GB SCHMALJOHN, CS TI A VACCINIA VIRUS-VECTORED HANTAAN-VIRUS VACCINE PROTECTS HAMSTERS FROM CHALLENGE WITH HANTAAN AND SEOUL-VIRUS BUT NOT PUUMALA-VIRUS SO JOURNAL OF VIROLOGY LA English DT Article ID KOREAN HEMORRHAGIC-FEVER; RENAL SYNDROME; ETIOLOGIC AGENT; MESSENGER-RNA; NUCLEOTIDE; HANTAVIRUSES; SEQUENCE; IMMUNITY; SEGMENTS; VOLES AB To investigate the ability of a vaccinia virus-vectored vaccine expressing the M and the S segments of Hantaan (HTN) virus (C. S. Schmaljohn, S. E. Hasty, and J. M. Dalrymple, Vaccine 10:10-13, 1992) to elicit a protective immune response against other hantaviruses, we vaccinated hamsters with the recombinant vaccine and challenged them with HTN, Seoul (SEO), or Puumala (PUU) virus. Neutralizing antibodies to HTN virus were found in all vaccinated hamsters both before and after challenge. Neutralizing antibody titers to SEO virus were present at low levels or were undetectable after two immunizations with the vaccine but were positive in all vaccinated hamsters after challenge with SEO virus and were also positive in control animals that were not challenged. Neutralizing antibodies to PUU virus were observed only in hamsters previously challenged with PUU virus. To assay for virus in the blood and tissues of the hamsters, we developed a nested reverse transcriptase (RT)-PCR with cross-reactive outer primers and serotype-specific inner primers. The RT-PCR specifically detected as little as 1 PFU of virus in serum containing high-titer neutralizing antibodies and was more sensitive than immunofluorescent antibody staining for detecting virus in lung and kidney specimens of infected hamsters. By using the RT-PCR, we found that vaccinated hamsters, challenged with HTN or SEO virus, neither were viremic nor had evidence of virus in their lungs or kidneys. In contrast, vaccinated hamsters challenged with PUU virus were viremic and had PUU virus-specific nucleic acid in their organs. C1 USA, MED RES INST INFECT DIS, DIV VIROL, FT DETRICK, MD 21702 USA. NR 32 TC 72 Z9 76 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD OCT PY 1995 VL 69 IS 10 BP 6417 EP 6423 PG 7 WC Virology SC Virology GA RU784 UT WOS:A1995RU78400055 PM 7666542 ER PT J AU SARIBANSOHRABY, S FISHER, RS AF SARIBANSOHRABY, S FISHER, RS TI GUANINE NUCLEOTIDE-DEPENDENT CARBOXYMETHYLATION - A PATHWAY FOR ALDOSTERONE MODULATION OF APICAL NA+ PERMEABILITY IN EPITHELIA SO KIDNEY INTERNATIONAL LA English DT Article ID SENSITIVE SODIUM-CHANNEL; CARBOXYL METHYLATION; SIGNAL TRANSDUCTION; PERTUSSIS TOXIN; HORMONAL-REGULATION; MEMBRANE-VESICLES; COLLECTING DUCT; URINARY-BLADDER; BINDING PROTEIN; TOAD BLADDER C1 WALTER REED ARMY INST RES,DEPT NEPHROL,WASHINGTON,DC 20307. FREE UNIV BRUSSELS,PHYSIOPATHOL LAB,BRUSSELS,BELGIUM. NR 66 TC 18 Z9 18 U1 0 U2 0 PU BLACKWELL SCIENCE PUBL INC CAMBRIDGE PI CAMBRIDGE PA 238 MAIN ST, CAMBRIDGE, MA 02142 SN 0085-2538 J9 KIDNEY INT JI Kidney Int. PD OCT PY 1995 VL 48 IS 4 BP 965 EP 969 DI 10.1038/ki.1995.378 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA RV926 UT WOS:A1995RV92600008 PM 8569106 ER PT J AU GUO, ZM LIU, CT AF GUO, ZM LIU, CT TI ROLE OF ATRIAL-NATRIURETIC-PEPTIDE IN DISTURBED WATER AND ELECTROLYTE METABOLISM OF GUINEA-PIGS INFECTED WITH PICHINDE VIRUS SO LABORATORY ANIMAL SCIENCE LA English DT Article ID POSSIBLE INVOLVEMENT; RAT; PATHOGENESIS; RELEASE; ATRIOPEPTIN; HOMEOSTASIS; ANTAGONISTS; MECHANISMS; SYSTEM; FLUID AB Daily intake and output of water and electrolytes (Na+, K+, and Cl-) were determined for 14 days in control and Pichinde virus-infected strain-13 guinea pigs. Although water intake began to decrease 7 days after virus inoculation, total daily water output (insensible water loss, urine excretion, plus fecal water loss) had little change, However, insensible water loss alone increased markedly in the virus infected animals. Both intake and excretions of urinary and fecal electrolytes decreased at the middle (days 7 to 10) and late (days 11 to 14) stages of viral infection. Differences between intake and output of water and electrolytes were reduced significantly during these periods, To determine a possible relationship between atrial natriuretic peptide (ANP) and urinary Na+ and water excretion over intake, we measured plasma ANP concentrations. The mean control value of plasma ANP was 24 +/- 1.0 pg/ml, and plasma ANP concentrations of infected animals increased significantly (P < 0.01) to 49.5 +/- 3.9 and 51.3 +/- 8.8 pg/ml on postinoculation days 7 and 12, Because the overall physiologic responses to Pichinde virus infection are complicated, it is difficult to postulate a single central theme concerning the pathogenesis. Nevertheless, we hypothesize that the virus-induced invisible tissue ''biochemical lesions'' and the consequential release of mediators and hormones were possible causes of death. Among other pathophysiologic mechanisms, the increased plasma ANP concentration may have played a role in the development of disturbed water and electrolytes metabolism during Pichinde virus infection. C1 USA,MED RES INST INFECT DIS,DEPT CLIN & EXPTL PHYSIOL,DIV DIS ASSESSMENT,FREDERICK,MD 21702. NR 37 TC 1 Z9 1 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD OCT PY 1995 VL 45 IS 5 BP 484 EP 492 PG 9 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA TB765 UT WOS:A1995TB76500003 PM 8569144 ER PT J AU ANDERSON, G WHELEN, AC AF ANDERSON, G WHELEN, AC TI NITRATE REACTION OF STAPHYLOCOCCUS-XYLOSUS ATCC-35663 SO LABORATORY MEDICINE LA English DT Letter RP ANDERSON, G (reprint author), BROOKE ARMY MED CTR,DEPT PATHOL,MICROBIOL LABS,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLIN PATHOLOGISTS PI CHICAGO PA 2100 W HARRISON ST, CHICAGO, IL 60612 SN 0007-5027 J9 LAB MED JI Lab. Med. PD OCT PY 1995 VL 26 IS 10 BP 623 EP 623 PG 1 WC Medical Laboratory Technology SC Medical Laboratory Technology GA RW431 UT WOS:A1995RW43100005 ER PT J AU BARTH, J AF BARTH, J TI MINING INVESTMENT RESOURCES FOR LIBRARIES SO LIBRARY JOURNAL LA English DT Editorial Material RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 51 EP 52 PG 2 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900038 ER PT J AU BARTH, J AF BARTH, J TI PLANNING FOR THE FUTURE - PROVIDING A MEANINGFUL LIFE FOR A CHILD WITH A DISABILITY AFTER YOUR DEATH - RUSSELL,LM SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 52 EP 52 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900042 ER PT J AU BARTH, J AF BARTH, J TI FINANCIAL SELF-DEFENSE FOR UNMARRIED COUPLES - HOW TO GAIN FINANCIAL PROTECTION DENIED BY LAW - ELKIN,LM SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 52 EP 52 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900040 ER PT J AU BARTH, J AF BARTH, J TI THE NEW-YORK-TIMES PERSONAL FINANCE HANDBOOK - SLOANE,L SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 52 EP 53 PG 2 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900043 ER PT J AU BARTH, J AF BARTH, J TI THE WALL-STREET-JOURNAL GUIDE TO PLANNING YOUR FINANCIAL FUTURE - MORRIS,KM, SIEGEL,AM SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 52 EP 52 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900041 ER PT J AU BARTH, J AF BARTH, J TI YOUR WEALTH-BUILDING YEARS - FINANCIAL-PLANNING FOR 18 TO 38 YEAR OLDS - BERG,AG SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 52 EP 52 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900039 ER PT J AU BARTH, J AF BARTH, J TI HOW TO INVEST 50-DOLLAR5-DOLLAR,000 - DUNNAN,N SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 3 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 53 EP 53 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900046 ER PT J AU BARTH, J AF BARTH, J TI MOODYS INDUSTRIAL MANUAL SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 3 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 53 EP 53 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900054 ER PT J AU BARTH, J AF BARTH, J TI BEATING THE DOW - A HIGH RETURN, LOW-RISK METHOD FOR INVESTING IN THE DOW-JONES INDUSTRIAL STOCKS WITH AS LITTLE AS 5,000-DOLLARS - OHIGGINS,M SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 3 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 53 EP 53 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900049 ER PT J AU BARTH, J AF BARTH, J TI ESTATE AND RETIREMENT PLANNING ANSWER BOOK - MITCHELL,WD SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 3 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 53 EP 53 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900044 ER PT J AU BARTH, J AF BARTH, J TI THE INTELLIGENT INVESTOR - GRAHAM,B SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 3 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 53 EP 53 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900048 ER PT J AU BARTH, J AF BARTH, J TI PROFITING FROM CHAOS - USING CHAOS THEORY FOR MARKET TIMING, STOCK SELECTION, AND OPTION VALUATION - VAGA,T SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 3 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 53 EP 53 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900051 ER PT J AU BARTH, J AF BARTH, J TI WHAT DO YOU MEAN ITS NOT COVERED - A PRACTICAL GUIDE TO UNDERSTANDING INSURANCE IN A HIGH-RISK WORLD - WALSH,J SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 3 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 53 EP 53 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900045 ER PT J AU BARTH, J AF BARTH, J TI THE CRAFT OF INVESTING - TRAIN,J SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 3 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 53 EP 53 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900050 ER PT J AU BARTH, J AF BARTH, J TI STANDARD AND POORS REGISTER OF CORPORATIONS, DIRECTORS AND EXECUTIVES SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 3 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 53 EP 54 PG 2 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900056 ER PT J AU BARTH, J AF BARTH, J TI MOODYS BOND RECORD SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 3 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 53 EP 53 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900053 ER PT J AU BARTH, J AF BARTH, J TI MORNINGSTAR AMERICAN DEPOSITORY RECEIPTS SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 3 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 53 EP 53 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900055 ER PT J AU BARTH, J AF BARTH, J TI DIVIDENDS DONT LIE - FINDING VALUE IN BLUE CHIP STOCKS - WEISS,G, LOWE,J SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 3 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 53 EP 53 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900052 ER PT J AU BARTH, J AF BARTH, J TI COMMON-STOCKS AND UNCOMMON PROFITS - FISHER,PA SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 3 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 53 EP 53 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900047 ER PT J AU BARTH, J AF BARTH, J TI MORNINGSTAR MUTUAL FUNDS SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 54 EP 54 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900061 ER PT J AU BARTH, J AF BARTH, J TI VALUE LINE INVESTMENT SURVEY SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 54 EP 54 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900057 ER PT J AU BARTH, J AF BARTH, J TI MUTUAL FUND PANORAMA - CDA-WIESENBERGER SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 54 EP 54 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900059 ER PT J AU BARTH, J AF BARTH, J TI MORNINGSTAR CLOSED-END FUNDS SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 54 EP 54 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900060 ER PT J AU BARTH, J AF BARTH, J TI VALUE LINE MUTUAL FUND SURVEY SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 54 EP 54 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900062 ER PT J AU BARTH, J AF BARTH, J TI VALUE LINE OTC SPECIAL SITUATION SERVICE SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 54 EP 54 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900058 ER PT J AU BURGES, EB AF BURGES, EB TI MYST - THE BOOK OF ATRUS - MILLER,R, MILLER,R, WINGROVE,D SO LIBRARY JOURNAL LA English DT Book Review RP BURGES, EB (reprint author), USA,TRALINET CTR,FT MONROE,VA, USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1995 VL 120 IS 16 BP 120 EP 120 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RW889 UT WOS:A1995RW88900278 ER PT J AU KORTE, DV SCHUMM, WR MAYBERRY, RW TILFORD, ML DUCKETT, MC AF KORTE, DV SCHUMM, WR MAYBERRY, RW TILFORD, ML DUCKETT, MC TI ENVIRONMENTAL-HEALTH ISSUES IN PRISONER OF WAR CAMPS SO MILITARY MEDICINE LA English DT Article AB Maintaining adequate environmental health and sanitation conditions in prisoner of war camps is essential for the fulfillment of our international legal obligations under the Geneva Conventions, Insights from Desert Storm and other conflicts are discussed. C1 USA,BOOKER RESERVE TRAINING CTR,MIL POLICE DETACHMENT 439,POW ADIVSORY TEAM,OMAHA,NE 68111. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1995 VL 160 IS 10 BP 483 EP 486 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA RZ326 UT WOS:A1995RZ32600004 PM 7501192 ER PT J AU GONZALVES, PE MINDERLER, JJ TOMPKINS, DL AF GONZALVES, PE MINDERLER, JJ TOMPKINS, DL TI A PATIENT SATISFACTION SURVEY - A BASIS FOR CHANGING DELIVERY OF SERVICES SO MILITARY MEDICINE LA English DT Article AB Through a collaborative effort with Kansas State University's Institute for Social and Behavioral Research, a marketing health care needs survey was conducted at Irwin Army Community Hospital prior to the implementation of coordinated care, The objectives of this survey were: (1) determine household health care program eligibility; (2) measure usage, perceptions, and barriers in our health care system; and (3) gauge interest in prospective changes or new programs, Using the results of this survey, valuable information was obtained for strategic planning and new programs were developed with the needs of our population in mind. RP GONZALVES, PE (reprint author), USA,DARNALL COMMUNITY HOSP,FT HOOD,TX 76544, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1995 VL 160 IS 10 BP 486 EP 488 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA RZ326 UT WOS:A1995RZ32600005 PM 7501193 ER PT J AU WITHERS, BG SMITH, SR EVENSON, ET WIENER, HA FORTUNE, GJ SVALINA, JS DAVILA, R AF WITHERS, BG SMITH, SR EVENSON, ET WIENER, HA FORTUNE, GJ SVALINA, JS DAVILA, R TI THE OCCUPATIONAL-HEALTH PARTNERSHIP PROGRAM - A NEW PARADIGM FOR OCCUPATIONAL-HEALTH SERVICES SO MILITARY MEDICINE LA English DT Article AB For a variety of reasons, occupational health services at Army Materiel Command installations became severely strained during the 1980s. The Occupational Health Partnership Program, developed to improve this support, describes control, responsibility, and cost sharing between Army Materiel Command and Army Medical Command. This innovative approach is finding new solutions to challenging problems, The authors describe the history, principles, status, and possible future of the partnership program. RP WITHERS, BG (reprint author), USA,MAT COMMAND,OFF SURGEON,ALEXANDRIA,VA 22333, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1995 VL 160 IS 10 BP 489 EP 491 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA RZ326 UT WOS:A1995RZ32600006 PM 7501194 ER PT J AU HAYUNGA, EG TROUMBLEY, PF CHEUNG, GP AF HAYUNGA, EG TROUMBLEY, PF CHEUNG, GP TI INDIVIDUAL MOBILIZATION AUGMENTATION - RECIPE FOR AN EFFECTIVE TOTAL FORCE PARTNERSHIP SO MILITARY MEDICINE LA English DT Article AB The ability to carry out rapid mobilization and full integration of well-trained reserve/guard personnel with active component personnel proved to be a decisive factor during the Gulf War. Such an approach can also be effective in fulfilling peacetime military missions, especially in an environment of increasing requirements, nontraditional missions, and pervasive force reductions, This paper describes the role played by Army Reserve Individual Mobilization Augmentation (IMA) assets in support of two important Army Medical Department missions involving new initiatives in scientific peer review and extramural grant administration: military nursing research and breast cancer, Successful planning, development, and implementation of these programs is attributed in part to the fostering of an effective partnership between reserve and active components on both individual and organizational levels, Critical factors influencing this partnership are analyzed and the relevance of such peacetime IMA taskings to wartime missions is discussed. RP HAYUNGA, EG (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1995 VL 160 IS 10 BP 496 EP 500 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA RZ326 UT WOS:A1995RZ32600009 PM 7501197 ER PT J AU KOSHES, RJ ROTHBERG, JM AF KOSHES, RJ ROTHBERG, JM TI AMBULATORY MENTAL-HEALTH-SERVICES AT A US ARMY COMBAT SUPPORT POST - THE EFFECTS OF THE PERSIAN-GULF-WAR SO MILITARY MEDICINE LA English DT Article AB A study of ambulatory mental health services on a U,S, Army post where logistic support personnel are stationed compared utilization of psychiatric services before, during, and after the Persian Gulf War, Rates were calculated for service utilization for the at-risk groups from consecutive cases presenting at the post's ambulatory mental health services in the Department of Psychiatry, Our findings include a high rate of dysfunction for soldiers in training during the war; significant age, race, and sex differences between utilizers and non-utilizers throughout the study period; increased routine evaluations for military schools following the war; and significant increases in utilization of services by identified high-stress units during this conflict, Rates of utilization for a combat support post can be used for resource allocation and have implications for mental health manpower planning and stress prevention. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307. NR 0 TC 1 Z9 1 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1995 VL 160 IS 10 BP 507 EP 513 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA RZ326 UT WOS:A1995RZ32600012 PM 7501200 ER PT J AU LENTZ, AE KERNS, DG AF LENTZ, AE KERNS, DG TI 20 COMMONLY DISPENSED MEDICATIONS AT A UNITED-STATES-MILITARY-INSTALLATION AND THEIR SIGNIFICANCE TO DENTISTS SO MILITARY MEDICINE LA English DT Article AB Understanding the clinical pharmacology of medications commonly used by dental patients is necessary when providing dental care. A significant number of patients may be taking medications that have the potential for adverse effects, The purpose of this paper is to familiarize dental practitioners with the clinical pharmacology of medications most likely to be encountered in a current military dental practice, Product activity reports (records of medication usage) were obtained from the main pharmacy at a United States Army Community Hospital. The product activity reports covered a 1-year period from December 31, 1992, to December 30, 1993. These reports were analyzed according to the number of medications dispensed to determine the 20 most commonly used medications. RP LENTZ, AE (reprint author), USA,TAYLOR DENT CLIN,DENT ACT,FT CAMPBELL,KY 42223, USA. NR 0 TC 4 Z9 4 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1995 VL 160 IS 10 BP 513 EP 518 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA RZ326 UT WOS:A1995RZ32600013 PM 7501201 ER PT J AU FRIEDL, KE KLICKA, MV KING, N MARCHITELLI, LJ ASKEW, EW AF FRIEDL, KE KLICKA, MV KING, N MARCHITELLI, LJ ASKEW, EW TI EFFECTS OF REDUCED FAT INTAKE ON SERUM-LIPIDS IN HEALTHY-YOUNG MEN AND WOMEN AT THE US-MILITARY-ACADEMY SO MILITARY MEDICINE LA English DT Article AB To assess the benefits of Army nutrition initiatives reducing intakes of fat and cholesterol, the authors studied the dietary intakes of cadets at the U,S. Military Academy and compared these results and related nutritional indicators (body composition, serum lipid status) to data obtained one decade earlier, The regular Cadet Mess menu provided 16.6 MJ/day of energy with 34% derived from fat, Actual intakes, including supplements, averaged 14.9 +/- 2.9 and 9.7 +/- 2.1 MJ/day for 119 male and 86 female cadets, respectively, Most cadets derived <35% of energy from dietary fat (11% from saturated fatty acids), representing a significant reduction since the previous study, in which nearly one-third of cadets received 40 to 45% of calories from fats; cholesterol intakes were markedly reduced, Serum cholesterol levels were approximately 7% lower, but were less affected than predicted by the reductions in fat and cholesterol intakes; serum low-density lipoprotein-cholesterol was also significantly reduced, Fasting serum insulin correlated with saturated fat intake in female cadets, indicating another health risk factor affected by intakes, The authors conclude that nutrition initiatives reducing energy derived from fats and total cholesterol intake have had a beneficial effect on the nutritional status of this fit young population. RP FRIEDL, KE (reprint author), USA,MED RES & MAT COMMAND,OPERAT MED RES PROGRAM,FT DETRICK,MD 21702, USA. OI Friedl, Karl/0000-0002-3134-8427 NR 0 TC 4 Z9 4 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1995 VL 160 IS 10 BP 527 EP 533 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA RZ326 UT WOS:A1995RZ32600016 PM 7501204 ER PT J AU POPE, RW HILL, JC BLASKIS, MG AF POPE, RW HILL, JC BLASKIS, MG TI CONTACT URTICARIA TO THE M17 PROTECTIVE MASK SO MILITARY MEDICINE LA English DT Note AB A case of contact urticaria to a compound used in the production of the M17 protective mask is reported, The new M40/42 series protective mask has a different composition, and should be tried as an alternative to the M17 mask in service members with black rubber allergies. RP POPE, RW (reprint author), USA,EISENHOWER MED CTR,FT GORDON,GA 30905, USA. NR 0 TC 4 Z9 4 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1995 VL 160 IS 10 BP 536 EP 537 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA RZ326 UT WOS:A1995RZ32600018 PM 7501206 ER PT J AU Hospenthal, DR Hicks, CB Green, DL Wiesen, AR Byrd, JC Isenbarger, DW Salzberg, DJ AF Hospenthal, DR Hicks, CB Green, DL Wiesen, AR Byrd, JC Isenbarger, DW Salzberg, DJ TI Trends in the incidence and diversity of fungi recovered from urine SO MYCOPATHOLOGIA LA English DT Article DE funguria; candiduria ID INFECTIONS; CANDIDIASIS; FLUCONAZOLE AB The diversity and incidence of fungal organisms recovered from the urine of patients at a tertiary level medical center was examined and compared over time. Mycologic culture records were examined for the 12 months prior to, and following the introduction of fluconazole to the hospital formulary in December 1991. 290 patients with 588 urine cultures from which fungi were recovered provided the database for this study. Candida albicans was the most common organism recovered in these cultures, followed by C. tropicalis. Torulopsis glabrata and C. parapsilosis. C. albicans was recovered alone in the urine of 54.4% of patients with funguria in the initial period and in 49.3% during the second. Funguria with T. glabrata nearly doubled (8.7% versus 17.1%) between these intervals (p < 0.05). Fungal urine cultures in the second period were also noted more frequently to grow multiple organisms (mixed cultures), and to show a greater diversity of species. Review of the prescribing of antifungal agents to these patient groups revealed no clear pattern of prior drug exposure influencing this change. Although introduction of fluconazole at this institution was associated with a trend toward the recovery of a higher frequency of fungi in the urine which are not C. albicans, no direct evidence to implicate the introduction of this important new antifungal as the cause of this phenomenon was found. C1 WALTER REED ARMY MED CTR,INFECT DIS SERV,DEPT MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,SERV PHARM,WASHINGTON,DC 20307. NR 15 TC 1 Z9 1 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0301-486X J9 MYCOPATHOLOGIA JI Mycopathologia PD OCT PY 1995 VL 132 IS 1 BP 15 EP 19 DI 10.1007/BF01138598 PG 5 WC Mycology SC Mycology GA TR471 UT WOS:A1995TR47100003 ER PT J AU SALAZAR, AM SCHWAB, K GRAFMAN, JH AF SALAZAR, AM SCHWAB, K GRAFMAN, JH TI PENETRATING INJURIES IN THE VIETNAM-WAR - TRAUMATIC UNCONSCIOUSNESS, EPILEPSY, AND PSYCHOSOCIAL OUTCOME SO NEUROSURGERY CLINICS OF NORTH AMERICA LA English DT Article ID HEAD-INJURY; PROGNOSTIC FACTORS; BRAIN; MORTALITY; PHENYTOIN; VETERANS; SEIZURES; CARE AB The WF Caveness Vietnam Head Injury Study includes over a thousand men who survived penetrating head injuries during the Vietnam War and on whom detailed medical and follow-up data are available. This population offers unique opportunities for the study of recovery from brain injury and of brain structure-function relationships. The authors briefly review long-term outcome in this cohort with respect to traumatic unconsciousness, posttraumatic epilepsy, and elements of psychologic and psychosocial function, including returning to work. C1 NINCDS,BETHESDA,MD 20892. RP SALAZAR, AM (reprint author), WALTER REED ARMY MED CTR,DEFENSE & VET HEAD INJURY PROGRAM,BLDG 7,ROOM 224,WASHINGTON,DC 20307, USA. NR 33 TC 20 Z9 20 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 1042-3680 J9 NEUROSURG CLIN N AM JI Neurosurg. Clin. N. Am. PD OCT PY 1995 VL 6 IS 4 BP 715 EP & PG 0 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA RZ142 UT WOS:A1995RZ14200012 PM 8527913 ER PT J AU MOHAN, RV AVILA, AF TAMMA, KK NAMBURU, RR AF MOHAN, RV AVILA, AF TAMMA, KK NAMBURU, RR TI 3-DIMENSIONAL TRANSIENT THERMAL-ANALYSIS WITH EXPLICIT FINITE-ELEMENT REPRESENTATIONS - PARALLEL IMPLEMENTATIONS AND PERFORMANCE STUDIES - THE CONNECTION MACHINE (CM-5) SO NUMERICAL HEAT TRANSFER PART B-FUNDAMENTALS LA English DT Article AB The recent trend in the computing industry is toward massively parallel platforms (MPPs) which permit highly scalable performance. These platforms are effective in finite-element computations involving large-scale computations. A significant change in data structures and algorithmic strategies are needed when such MPP computing systems ape used in finite-element computations. The article describes the implementation and data structure issues involved in the explicit three dimensional finite-element thermal analysis computations on such computing platforms. The present three-dimensional explicit finite-element formulations for general transient thermal analysis utilize the Galerkin finite-element representations and elicit solution algorithms. The present three-dimensional parallel finite-element implementations permit a full three-dimensional thermal analysis of large-scale structures, and evaluate the performance and applicability of MPP platforms. The data structures and programming models employed in these MPP platforms considers the concept of virtual processors. Tire performance of application codes depends on the virtual processor ratio. Studies involving the performance and effect of virtual processor ratios are presented and indicate that, for a gives physical number of processors, the performance increases with increase in virtual processor ratio and then sustains art asymptotic level. And, for massively parallel large finite-element meshes, sustained performance flop rates in double digits has been obtained in certain kernels. C1 UNIV MINNESOTA,INST TECHNOL,DEPT MECH ENGN,MINNEAPOLIS,MN 55455. COMP SCI CORP,ARMY HIGH PERFORMANCE COMP RES CTR,TARDEC,WARREN,MI. NR 14 TC 1 Z9 1 U1 0 U2 2 PU HEMISPHERE PUBL CORP PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 1040-7790 J9 NUMER HEAT TR B-FUND JI Numer Heat Tranf. B-Fundam. PD OCT-NOV PY 1995 VL 28 IS 3 BP 277 EP 291 DI 10.1080/10407799508928834 PG 15 WC Thermodynamics; Mechanics SC Thermodynamics; Mechanics GA TF031 UT WOS:A1995TF03100003 ER PT J AU LOFTS, CM RUFFIN, PB PARKER, M SUNG, CC AF LOFTS, CM RUFFIN, PB PARKER, M SUNG, CC TI INVESTIGATION OF THE EFFECTS OF TEMPORAL THERMAL-GRADIENTS IN FIBER OPTIC GYROSCOPE SENSING COILS SO OPTICAL ENGINEERING LA English DT Article DE THERMAL RADIAL GRADIENTS; NONRECIPROCITY; SENSING COILS; INTERFEROMETRIC FIBER OPTIC GYROSCOPES AB We investigate the effects of the nonreciprocity caused by time-varying, radial thermal gradients in interferometric fiber gyroscope sensing coils. Four identical sensing coils have been wound with elliptical core and Panda polarization-maintaining fibers in straight and quadrupolar wind configurations. The induced gyro bias drift, measured as a function of the elevated temperature and time, is presented and compared with a simple heat-conduction model, Qualitative agreement is reached with suitable choices of material parameters. C1 MORGAN RES CORP,HUNTSVILLE,AL 35805. UNIV ALABAMA,DEPT PHYS,HUNTSVILLE,AL 35899. RP LOFTS, CM (reprint author), USA,MISSILE COMMAND,AMSMI RD MG NC,REDSTONE ARSENAL,AL 35898, USA. NR 8 TC 21 Z9 22 U1 3 U2 5 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD OCT PY 1995 VL 34 IS 10 BP 2856 EP 2863 DI 10.1117/12.210771 PG 8 WC Optics SC Optics GA RZ708 UT WOS:A1995RZ70800005 ER PT J AU HUANG, Q GILBERT, JA AF HUANG, Q GILBERT, JA TI DIFFRACTION PROPERTIES OF SUBSTRATE GUIDED-WAVE HOLOGRAMS SO OPTICAL ENGINEERING LA English DT Article DE SUBSTRATE GUIDED-WAVE (SGW) HOLOGRAMS; BRAGG CONDITION; COUPLED WAVE THEORY; VOLUME HOLOGRAMS AB Substrate guided-wave (SGW) holograms, recorded and reconstructed using light waves guided through optical substrates, are currently being incorporated into visual displays, optical integrated circuits, and nondestructive testing systems. In this paper, a coupled wave approach is used to analyze the diffraction properties of SGW holograms. The expressions obtained allow SGW holograms to be compared with conventional transmission and reflection holograms. The analysis is restricted to cases in which holograms are recorded and reconstructed using plane waves. The object beam is also assumed to be at normal incidence to the hologram. Results are presented for holograms recorded on a silver halide emulsion and illuminated using a krypton laser. The study shows that SGW holograms have higher diffraction efficiencies under the Bragg condition, higher angular selectivities, and more. moderate wavelength selectivities than holograms recorded using conventional means. C1 UNIV ALABAMA,DEPT MECH & AEROSP ENGN,HUNTSVILLE,AL 35899. RP HUANG, Q (reprint author), USA,MISSILE COMMAND,WEAPONS SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. NR 12 TC 8 Z9 10 U1 0 U2 0 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD OCT PY 1995 VL 34 IS 10 BP 2891 EP 2899 DI 10.1117/12.210766 PG 9 WC Optics SC Optics GA RZ708 UT WOS:A1995RZ70800010 ER PT J AU SLINEY, DH AF SLINEY, DH TI RISK ASSESSMENT AND LASER SAFETY SO OPTICS AND LASER TECHNOLOGY LA English DT Article DE LASERS; RISK; PROBABILITY; EYE INJURIES; LASER SAFETY ID RETINAL INJURY; EYE AB The basic tenets of risk assessment have always been applied in laser safety during the development of safety standards. For example, statistical methods were used in the probit analysis of the threshold of ocular injury; concepts of risk analysis were employed in the development of hazard classes, where the increased risk of exposure and potential for injury from increasing laser output power led to assignment of an increasing hazard class. In recent years, however, there has been a number of attempts to apply statistical probability analysis in the risk assessment of actual use conditions. However, once the hazard classification has been assigned, how should one further apply the techniques of risk assessment in the determination of hazard control measures, or does this lead to a potential controversy of what is the risk! Risk analysis is the evaluation of potentially hazardous exposure conditions coupled with a realistic assessment of actual human exposure. The maximum permissible exposure values for laser radiation coupled with the laser hazards classification scheme, already permit realistic health hazard evaluations. However, in determining effective hazard control measures, one must perform a risk analysis. A risk analysis must consider aspects of human behaviour and how behaviour affects exposure. This is frequently the area of greatest controversy in the derivation of safety standards; however, it is this aspect where standards are most needed. RP SLINEY, DH (reprint author), USA,CTR HLTH PROMOT & PREVENT MED,LASER BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 28 TC 3 Z9 3 U1 0 U2 2 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA LINACRE HOUSE JORDAN HILL, OXFORD, OXON, ENGLAND OX2 8DP SN 0030-3992 J9 OPT LASER TECHNOL JI Opt. Laser Technol. PD OCT PY 1995 VL 27 IS 5 BP 279 EP 284 DI 10.1016/0030-3992(95)98684-K PG 6 WC Optics; Physics, Applied SC Optics; Physics GA TG737 UT WOS:A1995TG73700003 ER PT J AU GULLEY, ML SARGEANT, KP GRIDER, DJ EAGAN, PA DAVEY, DD DAMM, DD ROBINSON, RA VANDERSTEEN, DP MCGUFF, S BANKS, PM AF GULLEY, ML SARGEANT, KP GRIDER, DJ EAGAN, PA DAVEY, DD DAMM, DD ROBINSON, RA VANDERSTEEN, DP MCGUFF, S BANKS, PM TI LYMPHOMAS OF THE ORAL SOFT-TISSUES ARE NOT PREFERENTIALLY ASSOCIATED WITH LATENT OR REPLICATIVE EPSTEIN-BARR-VIRUS SO ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS LA English DT Article ID NON-HODGKINS-LYMPHOMAS; ACQUIRED-IMMUNODEFICIENCY-SYNDROME; T-CELL LYMPHOMAS; MORPHOLOGICAL SUBDIVISION; CLINICAL-SIGNIFICANCE; GENE-EXPRESSION; DNA; LEUKOPLAKIA; DISEASE; RNAS AB Objectives. Epstein-Barr virus is periodically shed in the saliva of persons infected by the virus.Epstein-Barr virus has been implicated in the pathogenesis of certain subtypes of lymphoma, particularly high-grade lymphomas. Because high-grade subtypes represent the majority of lymphomas that arise in oral soft tissues, we hypothesized that Epstein-Barr virus might be preferentially associated with oral lymphomas. Study Design, A series of 34 oral lymphomas were diagnosed according to the revised European-American classification scheme. They were examined for the presence of latent Epstein-Barr virus by EBER1 in situ hybridization and for expression of the Epstein-Barr virus replicative protein, BZLF1, by immunohistochemistry. Results, Epstein-Barr virus EBER1 transcripts were detected in 11 of 31 oral lymphomas including 7 of 10 AIDS-related lymphomas and only 4 of 21 lymphomas that occurred in nonimmunocompromised persons. The Epstein-Barr virus-containing lymphomas were art high-grade histologic subtypes, that is, diffuse large cell, immunoblastic, or Burkitt's lymphomas. In contrast, Epstein-Barr virus was not detected in any of five tow-grade oral lymphomas. in the single case of T-cell lymphoma in this study, EBER1 was expressed in the tumor cells. A switch from viral latency to replication, as measured by EBV BZLF1 expression, was identified in rare lymphoma cells in only four cases. This rate of viral replication was not higher than what has been reported in lymphomas arising at other anatomic sites. Although one of our lymphomas arose at a site oi previous oral hairy leukoplakia, there was no other evidence that Epstein-Barr virus replication predisposed to development or persistence of oral lymphomas. Conclusions. These data suggest that even though Epstein-Barr virus is frequently found in oral secretions, neither latent nor replicative Epstein-Barr virus is present more commonly in oral lymphomas than in lymphomas arising in other anatomic sites, when controlling for immunodeficiency status. C1 AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. UNIV KENTUCKY,MED CTR,LEXINGTON,KY 40506. UNIV IOWA HOSP & CLIN,IOWA CITY,IA 52242. WILFORD HALL USAF MED CTR,LACKLAND AFB,TX. RP GULLEY, ML (reprint author), UNIV TEXAS,HLTH SCI CTR,DEPT PATHOL,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284, USA. FU NCI NIH HHS [K08-CA01615] NR 35 TC 15 Z9 15 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 1079-2104 J9 ORAL SURG ORAL MED O JI Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. PD OCT PY 1995 VL 80 IS 4 BP 425 EP 431 PG 7 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA TA766 UT WOS:A1995TA76600015 PM 8521106 ER PT J AU VANDRE, RH WEBBER, RL AF VANDRE, RH WEBBER, RL TI FUTURE-TRENDS IN DENTAL RADIOLOGY SO ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS LA English DT Article ID DIGITAL SUBTRACTION RADIOGRAPHY; PERIODONTAL BONE-LESIONS; 35-MM FILM SCANNER; DIAGNOSIS; DIGITIZER; GEOMETRY; INVITRO; CARIES; RAY AB Direct digital dental radiographic systems offer the potential to radically change the way dentists diagnose and treat dental pathoses. They offer instantaneous availability of radiographs, markedly lower patient radiation exposure, and the elimination; of developing chemicals and developing equipment. The storage of dental radiographs as digital data permits their transmittal over phone lines facilitating phone consultations and may someday allow expedited authorization of treatment plans by dental insurance companies. With the use of digital subtraction radiology the dental practitioner will be able to diagnose periodontal disease progression and dental caries progression long before current techniques can detect a change. With tuned aperture computed tomography, the owner of a filmless digital system can make tomographic radiographs that allow the visualization of slices through areas of interest without having to buy additional hardware. Computer-aided diagnosis will facilitate the detection of proximal dental caries and osteoporosis, and may someday allow automated tracing of cephalometric radiographs. C1 WAKE FOREST UNIV,BOWMAN GRAY MED CTR,WINSTON SALEM,NC 27109. RP VANDRE, RH (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,USA DENT RES DETACHMENT,FT GEORGE G MEADE,MD 20755, USA. NR 46 TC 37 Z9 39 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 1079-2104 J9 ORAL SURG ORAL MED O JI Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. PD OCT PY 1995 VL 80 IS 4 BP 471 EP 478 PG 8 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA TA766 UT WOS:A1995TA76600022 PM 8521112 ER PT J AU GUPTA, L SORTRAKUL, T CHARLES, A KISATSKY, P AF GUPTA, L SORTRAKUL, T CHARLES, A KISATSKY, P TI ROBUST AUTOMATIC TARGET RECOGNITION USING A LOCALIZED BOUNDARY REPRESENTATION SO PATTERN RECOGNITION LA English DT Article; Proceedings Paper CT 1st International Symposium on AIES (Adaptive Intelligent Energy Systems) CY FEB, 1993 CL BRUSSELS, BELGIUM SP Commiss European Communities, Directorate Gen XII, Cranfield Univ UK, Int Fdn Artificial Intelligence Japan DE AUTOMATIC TARGET RECOGNITION; PARTIAL TARGETS; TARGET REPRESENTATION; LOCAL FEATURES ID PARTIAL SHAPE CLASSIFICATION; DYNAMIC ALIGNMENT; OBJECTS AB A localized classification approach which includes a localized target boundary representation, a set of local features to characterize parts of a target boundary, and a feature matching method is developed to classify highly degraded targets. Each pixel on the target boundary is represented by the perpendicular Euclidean distance between the boundary pixel and the chord connecting the end-points of a window centered on the boundary pixel. The resulting localized representation is quite robust with respect to noise and missing segments in the targets. A local feature is the segment of the localized representation between two points selected on the target boundary. The two points on the boundary may be specified or randomly selected. The reference features of a hypothesized target class are compared with segments of the localized representation of the test target to determine a dissimilarity measure between the hypothesized target class and the test target. Segments of the test target may also be matched with the reference localized contour sequences of the targets. The test target is assigned to a target class using a minimum mismatch rule. Results from a series of experiments conducted on three targets show that it is possible to classify targets experiencing high levels of noise and high percentages of missing segments in partial targets. C1 USA ARMAMENTS,CTR RES DEV & ENGN,PICATINNY ARSENAL,NJ 07806. RP GUPTA, L (reprint author), SO ILLINOIS UNIV,DEPT ELECT ENGN,CARBONDALE,IL 62901, USA. NR 18 TC 6 Z9 6 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0031-3203 J9 PATTERN RECOGN JI Pattern Recognit. PD OCT PY 1995 VL 28 IS 10 BP 1587 EP 1598 DI 10.1016/0031-3203(94)00023-F PG 12 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic SC Computer Science; Engineering GA TA237 UT WOS:A1995TA23700015 ER PT J AU MCGOWAN, AS AF MCGOWAN, AS TI REACHING THE PUBLIC THROUGH CABLE AND EDUCATIONAL-TELEVISION SO PHI DELTA KAPPAN LA English DT Article C1 US MIL ACAD,GRAD PROGRAM COUNSELING,W POINT,NY 10996. RP MCGOWAN, AS (reprint author), LONG ISL UNIV,GRAD PROGRAM COUNSELING & DEV,BROOKVILLE,NY, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU PHI DELTA KAPPA PI BLOOMINGTON PA 8TH AND UNION P O BOX 789, BLOOMINGTON, IN 47402 SN 0031-7217 J9 PHI DELTA KAPPAN JI Phi Delta Kappan PD OCT PY 1995 VL 77 IS 2 BP 182 EP 184 PG 3 WC Education & Educational Research SC Education & Educational Research GA RX789 UT WOS:A1995RX78900016 ER PT J AU LEWIS, BR ENGLAND, JP WINKEL, RJ BANERJEE, SS DOOLEY, PM GIBSON, ST BALDWIN, KGH AF LEWIS, BR ENGLAND, JP WINKEL, RJ BANERJEE, SS DOOLEY, PM GIBSON, ST BALDWIN, KGH TI EXPERIMENTAL-OBSERVATION OF THE LOWEST (1)SIGMA(+)(U) VALENCE STATE OF O-2 SO PHYSICAL REVIEW A LA English DT Article ID DISSOCIATIVE RECOMBINATION; CONFIGURATION INTERACTION; POTENTIAL CURVES; O2; PREDISSOCIATION; GENERATION; RADIATION; SPECTRUM; O(1S); O(1D) AB Transitions into the lowest (1) Sigma(u)(+) valence state of O-2, which we shall name f'(1) Sigma(u)(+), are observed. A total of nine weak absorption bands is found from the system f'(1) Sigma(u)(+)<--X(3) Sigma(g)(-) for the isotopes O-16(2) and O-18(2). The observed band origins and rotational constants are found to be significantly perturbed due to an electrostatic interaction between the valence state f'(1) Sigma(u)(+) and the Rydberg states 3p pi(u)f(1) Sigma(u)(+) and 4p pi(u)j(1) Sigma(u)(+). In addition, rotational perturbations observed in certain vibrational levels of the Rydberg states f(1) Sigma(u)(+) and j(1) Sigma(u)(+) are found to be caused by the f'(1) Sigma(u)(+) state through the same valence-Rydberg interaction. The f'<--X bands are found to be predissociating resonances that exhibit Beutler-Fano line shapes of widely varying asymmetry. In particular, the (13,0) band of O-18(2) is an example of a window resonance in molecular dissociation. C1 US MIL ACAD,DEPT PHYS,W POINT,NY 10996. RP LEWIS, BR (reprint author), AUSTRALIAN NATL UNIV,RES SCH PHYS SCI & ENGN,CANBERRA,ACT 0200,AUSTRALIA. RI Baldwin, Kenneth/A-4928-2008 OI Baldwin, Kenneth/0000-0002-2043-5330 NR 49 TC 20 Z9 20 U1 1 U2 6 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD OCT PY 1995 VL 52 IS 4 BP 2717 EP 2733 DI 10.1103/PhysRevA.52.2717 PG 17 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA TA424 UT WOS:A1995TA42400035 ER PT J AU WREN, GP COFFEE, TP DESPIRITO, J KNAPTON, JD KLINGENBERG, G AF WREN, GP COFFEE, TP DESPIRITO, J KNAPTON, JD KLINGENBERG, G TI PRESSURE OSCILLATIONS IN REGENERATIVE LIQUID PROPELLANT GUNS SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article AB The present paper deals with pressure oscillations in regenerative liquid propellant guns (RLPG) presenting the state-of-the-art research into sources and control of these combustion instabilities. Pressure oscillations with amplitudes up to 50% of mean pressure and frequencies up to 60 kHz or more are present in experimental data of RLPGs, especially at medium and large calibers. Amplitudes increase with the volumetric energy density of the liquid propellant and the mass flow rate during injection. Frequency analyses reveal that both acoustic modes and combustion noise are components of the recorded oscillations. Acoustic modes, in particular, have the potential to couple to resonant modes in near-field mechanical structures. A multi-phase, multi-dimensional model investigation at ARL indicates that pressure waves reflected from internal boundaries are amplified as they pass the combustion zone of the highly pressure-sensitive liquid propellant in a localized region near the injector. Experimental data lead to a similar understanding of the amplification of pressure oscillations in RLPGs. Experiments in the United States and in Germany confirm that the pressure oscillations can be mitigated by altering the combustion characteristics of the liquid propellant. Also, techniques that more effectively disperse the liquid propellant jet and thereby decrease the local accumulation of liquid propellant, may reduce pressure oscillations as shown in 30-mm RLPG experiments. Further, energy-absorbing chamber walls or liners can serve as broad-band filters and have been shown experimentally to be effective in reducing the amplitude of all frequencies. In addition, physical methods such as cavities and baffles reduce significantly specific acoustic frequencies of the oscillations. C1 ERNST MACH INST,FRAUNHOFER INST KURZZEITDYNAM,D-79576 WEIL AM RHEIN,GERMANY. RP WREN, GP (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD, USA. NR 21 TC 2 Z9 2 U1 0 U2 0 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD OCT PY 1995 VL 20 IS 5 BP 225 EP 231 DI 10.1002/prep.19950200502 PG 7 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA TJ455 UT WOS:A1995TJ45500001 ER PT J AU PAYNE, BS MILLER, AC LEI, J AF PAYNE, BS MILLER, AC LEI, J TI PALP TO GILL AREA RATIO OF BIVALVES - A SENSITIVE INDICATOR OF ELEVATED SUSPENDED-SOLIDS SO REGULATED RIVERS-RESEARCH & MANAGEMENT LA English DT Article; Proceedings Paper CT International Conference on Sustaining the Ecological Integrity of Large Floodplain Rivers - Application of Ecological Knowledge to River Management CY JUL 12-15, 1994 CL LA CROSSE, WI SP Natl Biol Serv, Environm Management Tech Ctr DE BIVALVES; ECOPHENOTYPIC VARIATIONS; FRESH-WATER BIVALVES; GILLS; PALPS; SUSPENDED SOLIDS; SUSPENDED SOLIDS EFFECTS AB Area measurements were made of the gills and labial palps of several freshwater bivalve species from sites with distinctly different suspended solids concentrations. Without exception, the palp to gill area ratio (PA:GA) was markedly higher for populations from sites with high versus low suspended solids concentrations. The average PA:GA (expressed as a percentage) ranged from 9.3 to 11.5 for bivalves from high suspended solids concentration sites and from 2.5 to 4.8 for bivalves from low suspended solids concentration sites. Such interpopulation differences were observed for two introduced species, Dreissena polymorpha and Corbicula fluminea, despite extremely brief residence times in an evolutionary sense. At any particular location, different species of native unionids had similar PA:GA. These results suggest that PA:GA is a sensitive biological indicator of suspended solids concentration, with interpopulation differences probably reflecting ecophenotypic rather than genetic variation. RP PAYNE, BS (reprint author), USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180, USA. NR 0 TC 17 Z9 17 U1 0 U2 7 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0886-9375 J9 REGUL RIVER JI Regul. Rivers-Res. Manage. PD OCT PY 1995 VL 11 IS 2 BP 193 EP 200 DI 10.1002/rrr.3450110209 PG 8 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA TC926 UT WOS:A1995TC92600008 ER PT J AU STOCKSTILL, RL MARTIN, SK BERGER, RC AF STOCKSTILL, RL MARTIN, SK BERGER, RC TI HYDRODYNAMIC MODEL OF VESSEL-GENERATED CURRENTS SO REGULATED RIVERS-RESEARCH & MANAGEMENT LA English DT Article; Proceedings Paper CT International Conference on Sustaining the Ecological Integrity of Large Floodplain Rivers - Application of Ecological Knowledge to River Management CY JUL 12-15, 1994 CL LA CROSSE, WI SP Natl Biol Serv, Environm Management Tech Ctr DE DRAWDOWN; FINITE ELEMENT; NAVIGATION; NUMERICAL MODEL; PETROV-GALERKIN; RETURN CURRENTS; SHALLOW WATER EQUATIONS AB The drawdown and return currents of vessels navigating in channels have previously been described by empirical relations or by using physical models. The empirical solutions are generally limited in scope to idealized channel shapes. Physical models are unrestricted in this respect, but have limitations related to expense and scale effects. In this paper, vessel effects are modelled numerically. The vessel's displacement is represented by a moving pressure field. The movement of the pressure field is spatially varied in time, representing a vessel navigating along a channel. The hydrodynamics are described using the two-dimensional shallow water equations, which are modified to account for the effects of the imposed pressure field. A Petrov-Galerkin finite-element scheme using characteristic-based weighting is used to solve the governing equations. This Petrov-Galerkin test function is specifically designed to model flow fields containing large gradients such as those found in the vicinity of the moving vessel. The numerical results for return flows and water surface elevations are compared with flume results of vessel passages. RP STOCKSTILL, RL (reprint author), USA,ENGINEER WATERWAYS EXPT STN,CEWES HL,VICKSBURG,MS 39180, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0886-9375 J9 REGUL RIVER JI Regul. Rivers-Res. Manage. PD OCT PY 1995 VL 11 IS 2 BP 211 EP 225 DI 10.1002/rrr.3450110211 PG 15 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA TC926 UT WOS:A1995TC92600010 ER PT J AU SONG, GH ANDRE, RG SCHEIBEL, LW WIRTZ, RA STRICKMAN, DA CHERIATHUNDAM, E ALVARES, AP AF SONG, GH ANDRE, RG SCHEIBEL, LW WIRTZ, RA STRICKMAN, DA CHERIATHUNDAM, E ALVARES, AP TI PLASMODIUM-BERGHEI - SENSITIVITY OF CHLOROQUINE-RESISTANT AND CHLOROQUINE-SENSITIVE STRAINS TO IRRADIATION AND THE EFFECT OF IRRADIATED MALARIA PARASITES ON CYTOCHROME P450-DEPENDENT MONOOXYGENASES SO RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY LA English DT Article ID INDUCTION AB Differences in sensitivities of chloroquine-sensitive and chloroquine-resistant strains of Plasmodium berghei were observed following irradiation of the parasites. A dose of 15 kilorads from a cobalt-60 source killed the erythrocytic stages of the chloroquine-sensitive strain and no parasitemias were observed when mice were injected with these irradiated parasites. In contrast, when the chloroquine-resistant strain was irradiated with the same dose of cobalt-60 and injected into mice, an infection rate of 12.5% was observed, indicating that the latter strain was more resistant to inactivation by irradiation. Following injection of these irradiated strains of P. berghei into mice, significant decreases in mouse hepatic cytochrome P450 and benzo(a)pyrene hydroxylase activity, with no significant effect on N-demethylase activity, were observed. Serum glutamic-oxaloacetic transaminase (SCOT) and glutamic-pyruvic transaminase (SGPT) levels of mice injected with the irradiated parasites fell within the range of the serum enzyme levels in normal laboratory mice. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PHARMACOL,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT PREVENT MED & BIOMETR,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTOMOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. NR 21 TC 1 Z9 1 U1 0 U2 0 PU P J D PUBLICATIONS LTD PI WESTBURY PA PO BOX 966, WESTBURY, NY 11590 SN 1078-0297 J9 RES COMMUN MOL PATH JI Res. Commun. Mol. Pathol. Pharmacol. PD OCT PY 1995 VL 90 IS 1 BP 75 EP 86 PG 12 WC Biochemistry & Molecular Biology; Pathology; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Pathology; Pharmacology & Pharmacy GA TC935 UT WOS:A1995TC93500008 PM 8581351 ER PT J AU BALINGIT, AG SLACK, MC ALLEN, S CARAVALHO, J RIVERA, JE RODRIGUEZ, AA AF BALINGIT, AG SLACK, MC ALLEN, S CARAVALHO, J RIVERA, JE RODRIGUEZ, AA TI RIGHT-VENTRICULAR (201)T1 UPTAKE ON MYOCARDIAL PERFUSION SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY IMAGING SO SEMINARS IN NUCLEAR MEDICINE LA English DT Article ID PULMONARY-HYPERTENSION; HEART-DISEASE; TL-201; CHILDREN C1 WALTER REED ARMY MED CTR,SERV CARDIOL,WASHINGTON,DC 20307. RP BALINGIT, AG (reprint author), WALTER REED ARMY MED CTR,DEPT RADIOL,NUCL MED SERV,WASHINGTON,DC 20307, USA. NR 16 TC 2 Z9 2 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0001-2998 J9 SEMIN NUCL MED JI Semin. Nucl. Med. PD OCT PY 1995 VL 25 IS 4 BP 348 EP 351 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA TC010 UT WOS:A1995TC01000008 PM 8545639 ER PT J AU DONOVAN, WH AF DONOVAN, WH TI THEORETICAL INVESTIGATION OF ISOTOPIC SCRAMBLING MECHANISMS IN 2-CHLOROETHYL METHYL SULFIDE SO STRUCTURAL CHEMISTRY LA English DT Article DE ISOTOPIC SCRAMBLING; 2-CHLOROETHYL METHYL SULFIDE; REACTION MECHANISM; SOLVATION ENERGIES ID AQUEOUS-SOLUTION; FREE-ENERGIES; MUSTARD DERIVATIVES; MOLECULAR-MODELS; SOLVATION; HYDROLYSIS; EQUILIBRIA; PM3-SM3; WATER AB Ab initio and semiempirical molecular orbital calculations have been applied to study the concerted and stepwise isotopic scrambling mechanisms of 2-chloroethyl methyl sulfide in the gas phase and in aqueous solution. The calculations reveal the structural details of the reactants, transition structures, and intermediates involved in this reaction and provide relative energy estimates. The concerted mechanism is found to be competitive with the stepwise mechanism in the gas phase, but the stepwise mechanism is favored in aqueous solution as no true transition structure for the concerted mechanism could be found using the solvation models. A combined approach of evaluating solvation energies with the generalized-Born-plus-surface-tensions SMx solvation models of Cramer and Truhlar at ab initio optimized geometries is found to deliver the best agreement with experimentally determined reaction barriers. Together with the recent experimental results of McManus and co-workers, the present study provides insights into the controlling factors involved in the elementary reaction steps of sulfur mustards and a solid foundation for investigations into more complex reactions of related compounds. RP DONOVAN, WH (reprint author), USA,EDGEWOOD RES DEV & ENGN CTR,SCBRD,RTC,BLDG E3160,ABERDEEN PROVING GROUND,MD 21010, USA. NR 48 TC 2 Z9 2 U1 0 U2 0 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 1040-0400 J9 STRUCT CHEM JI Struct. Chem. PD OCT PY 1995 VL 6 IS 4-5 BP 243 EP 254 DI 10.1007/BF02293117 PG 12 WC Chemistry, Multidisciplinary; Chemistry, Physical; Crystallography SC Chemistry; Crystallography GA TA172 UT WOS:A1995TA17200005 ER PT J AU LOWREY, AH FAMINI, GR AF LOWREY, AH FAMINI, GR TI USING THEORETICAL DESCRIPTORS IN QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS - HPLC CAPACITY FACTORS FOR ENERGETIC MATERIALS SO STRUCTURAL CHEMISTRY LA English DT Article DE EXPLOSIVES; SOLVATION; COMPUTATIONAL CHEMISTRY; CHROMATOGRAPHY; QSAR ID EXPLOSIVES AB The widespread application of computational techniques to studies in biology and chemistry has led to a quest for important characteristic properties that may be directly derived from these methods. The theoretical linear solvation energy relationships (TLSER) have successfully replaced empirical parameters, such as in the linear solvation energy relationships (LSER) of Kamlet and Taft, with theoretical descriptors that are consistently derived for a wide variety of chemical and biological properties and for a large range of molecules. These descriptors are small in number, well-defined in theoretical terms, and provide a systematic basis for computational studies of complex phenomena. Energetic materials are a class of molecules whose explosive characteristics have been previously studied by empirical methods. The forensic and environmental sciences have prompted the conduct of detailed high performance liquid chromatography (HPLC) studies for identifying of trace quantities of commonly used explosives. The TLSER methodology provides good correlations between the calculated quantities and the experimentally determined HPLC capacity factors. This provides a reasonable interpretation of retention times in terms of molecular volume and quantities associated with acidity and basicity. C1 USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD. RP LOWREY, AH (reprint author), USN,RES LAB,STRUCT MATTER LAB,WASHINGTON,DC 20375, USA. NR 30 TC 13 Z9 13 U1 1 U2 5 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 1040-0400 J9 STRUCT CHEM JI Struct. Chem. PD OCT PY 1995 VL 6 IS 4-5 BP 357 EP 365 DI 10.1007/BF02293131 PG 9 WC Chemistry, Multidisciplinary; Chemistry, Physical; Crystallography SC Chemistry; Crystallography GA TA172 UT WOS:A1995TA17200019 ER PT J AU BRANDT, JT TRIPLETT, DA ALVING, B SCHARRER, I AF BRANDT, JT TRIPLETT, DA ALVING, B SCHARRER, I TI CRITERIA FOR THE DIAGNOSIS OF LUPUS ANTICOAGULANTS - AN UPDATE SO THROMBOSIS AND HAEMOSTASIS LA English DT Note ID PARTIAL THROMBOPLASTIN TIME; ANTIPHOSPHOLIPID ANTIBODIES; NEUTRALIZATION TEST; CLOTTING TIME; PLASMA; HYPOPROTHROMBINEMIA C1 BALL MEM HOSP,DEPT PATHOL,MUNCIE,IN 47303. WALTER REED ARMY INST RES,DEPT HEMATOL,WASHINGTON,DC. UNIV HOSP FRANKFURT,DEPT INTERNAL MED,FRANKFURT,GERMANY. RP BRANDT, JT (reprint author), OHIO STATE UNIV,DEPT PATHOL,164 HAMILTON HALL,164 NEIL AVE,COLUMBUS,OH 43210, USA. RI Scharrer, Inge/N-2999-2013 NR 41 TC 1027 Z9 1046 U1 3 U2 4 PU F K SCHATTAUER VERLAG GMBH PI STUTTGART PA P O BOX 10 45 45, LENZHALDE 3, D-70040 STUTTGART, GERMANY SN 0340-6245 J9 THROMB HAEMOSTASIS JI Thromb. Haemost. PD OCT PY 1995 VL 74 IS 4 BP 1185 EP 1190 PG 6 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA TA951 UT WOS:A1995TA95100034 PM 8560433 ER PT J AU LAPENOTIERE, HF CLAYTON, MA MIDDLEBROOK, JL AF LAPENOTIERE, HF CLAYTON, MA MIDDLEBROOK, JL TI EXPRESSION OF A LARGE, NONTOXIC FRAGMENT OF BOTULINUM NEUROTOXIN SEROTYPE-A AND ITS USE AS AN IMMUNOGEN SO TOXICON LA English DT Note ID ESCHERICHIA-COLI; TETANUS AB Using the polymerase chain reaction, a large fragment of botulinum toxin was placed in two expression systems, one designed to produce a fusion protein product and another designed to produce only the toxin fragment. Expression of the fragment in the latter system was inconsistent. Expression of the fusion protein was easily measurable by ELISA. Mice were vaccinated with crude fusion protein, then challenged with native toxin. Mice receiving two immunizations were partially protected from up to 1200 LD(50) suggesting that this toxin fragment may be a good vaccine candidate to replace the currently used toxoid. C1 USA,DUGWAY PROVING GROUND,DIV LIFE SCI,DUGWAY PROVING GROUND,UT 84022. USA,MED RES INST INFECT DIS,DIV TOXINOL,FREDERICK,MD 21702. NR 8 TC 43 Z9 48 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD OCT PY 1995 VL 33 IS 10 BP 1383 EP 1386 DI 10.1016/0041-0101(95)00072-T PG 4 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA TB554 UT WOS:A1995TB55400014 PM 8599190 ER PT J AU GAMBEL, JM BROWN, AE DRABICK, JJ PETRUCCELLI, BP BRUNDAGE, JF AF GAMBEL, JM BROWN, AE DRABICK, JJ PETRUCCELLI, BP BRUNDAGE, JF TI RISK OF LATE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 SEROCONVERSION IN UNITED-STATES SOLDIERS WHOSE INITIAL SCREENING-TESTS WERE REACTIVE SO TRANSFUSION LA English DT Letter C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT DIAGNOST RETROVIROL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. USA,CTR HLTH PROMOT & PREVENT MED PROVIS,ABERDEEN PROVING GROUND,MD 21010. RP GAMBEL, JM (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV PREVENT MED,WASHINGTON,DC 20307, USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU AMER ASSOC BLOOD BANKS PI BETHESDA PA 8101 GLENBROOK RD, BETHESDA, MD 20814-2749 SN 0041-1132 J9 TRANSFUSION JI Transfusion PD OCT PY 1995 VL 35 IS 10 BP 886 EP 887 DI 10.1046/j.1537-2995.1995.351096026377.x PG 2 WC Hematology SC Hematology GA TA448 UT WOS:A1995TA44800020 PM 7570926 ER PT J AU HESS, JR AF HESS, JR TI BLOOD PRODUCT REQUIREMENTS FOR NATIONAL DEFENSE SO TRANSFUSION LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC BLOOD BANKS PI BETHESDA PA 8101 GLENBROOK RD, BETHESDA, MD 20814-2749 SN 0041-1132 J9 TRANSFUSION JI Transfusion PD OCT PY 1995 VL 35 IS 10 SU S BP A27 EP A27 PG 1 WC Hematology SC Hematology GA TB478 UT WOS:A1995TB47800294 ER PT J AU BETENBAUGH, M YU, MC KUEHL, K WHITE, J PENNOCK, D SPIK, K SCHMALJOHN, C AF BETENBAUGH, M YU, MC KUEHL, K WHITE, J PENNOCK, D SPIK, K SCHMALJOHN, C TI NUCLEOCAPSID-LIKE AND VIRUS-LIKE PARTICLES ASSEMBLE IN CELLS INFECTED WITH RECOMBINANT BACULOVIRUSES OR VACCINIA VIRUSES EXPRESSING THE M-SEGMENTS AND THE S-SEGMENTS OF HANTAAN-VIRUS SO VIRUS RESEARCH LA English DT Article DE HANTAAN VIRUS; VIRUS-LIKE PARTICLE; BACULOVIRUS; VACCINIA VIRUS ID HEMORRHAGIC-FEVER; RENAL SYNDROME; INSECT CELLS; MONOCLONAL-ANTIBODIES; PROTEINS; HANTAVIRUSES; RNA; L1; REQUIREMENTS; POLYPROTEIN AB The formation of Hantaan (HTN) virus nucleocapsid-like structures (NLS) or virus-like particles (VLP) from expressed gene products was investigated in two eukaryotic systems. Baculovirus expression of the HTN virus Small segment (S), which encodes the viral nucleocapsid protein, resulted in assembly of NLS inside infected insect cells. The NLS and authentic ribonucleocapsids, prepared by detergent disruption of HTN virions, had similar sedimentation characteristics and morphologies, and were recognized by HTN virus N-specific antibodies. Co-expression of S and the medium segment (M), which encodes the two viral envelope glycoproteins (G1 and G2), did not efficiently generate VLP in the baculovirus-insect cell system, but VLP were observed in lysates and supernatants of cells infected with a recombinant vaccinia virus co-expressing HTN virus M and S. The VLP sedimented in sucrose to densities consistent with HTN virions, and some of them bore a striking resemblance to Hantaan virions when examined by immunoelectron microscopy. C1 USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21702. JOHNS HOPKINS UNIV,DEPT CHEM ENGN,BALTIMORE,MD 21218. USA,MED RES INST INFECT DIS,DIV PATHOL,FT DETRICK,MD 21702. RI Betenbaugh, Michael J./A-3252-2010 OI Betenbaugh, Michael J./0000-0002-6336-4659 NR 38 TC 40 Z9 42 U1 3 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-1702 J9 VIRUS RES JI Virus Res. PD OCT PY 1995 VL 38 IS 2-3 BP 111 EP 124 DI 10.1016/0168-1702(95)00053-S PG 14 WC Virology SC Virology GA RZ285 UT WOS:A1995RZ28500002 PM 8578853 ER PT J AU TORTELLA, FC KLETTE, KL DECOSTER, MA DAVIS, BJ NEWMAN, AH AF TORTELLA, FC KLETTE, KL DECOSTER, MA DAVIS, BJ NEWMAN, AH TI DEXTROMETHORPHAN ANALOGS ARE NEUROPROTECTIVE IN-VITRO AND BLOCK GLUTAMATE-INDUCED EXCITOTOXIC CALCIUM SIGNALS IN NEURONS SO NEUROSCIENCE LETTERS LA English DT Article DE DEXTROMETHORPHAN; DEXTROMETHORPHAN ANALOGS; GLUTAMATE; NEURONAL INJURY; CALCIUM; CELL CULTURE ID NEUROTOXICITY; DEXTRORPHAN; LIGANDS AB Consistent with the neuroprotective effects of the non-opioid antitussive dextromethorphan (DM) described in several models of CNS injury, micromolar concentrations of three novel analogs of DM markedly attenuated the injury produced by glutamate in cultured rat cortical neurons. Furthermore, the neuroprotective actions of the DM analogs correlated with their effects to block glutamate-induced excitotoxic calcium signals and were unrelated to metabolism to the phencyclidine (PCP)-like drug dextrorphan (DX). These observations establish a new class of compounds related to DM which, by virtue of their efficacy to protect neurons against a severe glutamate insult, may possess therapeutic potential as treatment modalities for a number of neurodegenerative diseases. C1 NIDA,ADDICT RES CTR,PSYCHOBIOL SECT,DRUG DEV GRP,BALTIMORE,MD 21224. RP TORTELLA, FC (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT NEUROPHARMACOL & MOLEC BIOL,WASHINGTON,DC 20307, USA. NR 13 TC 10 Z9 10 U1 0 U2 0 PU ELSEVIER SCI PUBL IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0304-3940 J9 NEUROSCI LETT JI Neurosci. Lett. PD SEP 29 PY 1995 VL 198 IS 2 BP 79 EP 82 DI 10.1016/0304-3940(95)11966-Z PG 4 WC Neurosciences SC Neurosciences & Neurology GA TA406 UT WOS:A1995TA40600003 PM 8592646 ER PT J AU TIDROW, MZ CHOI, KK DEANNI, AJ CHANG, WH SVENSSON, SP AF TIDROW, MZ CHOI, KK DEANNI, AJ CHANG, WH SVENSSON, SP TI GRATING-COUPLED MULTICOLOR QUANTUM-WELL INFRARED PHOTODETECTORS SO APPLIED PHYSICS LETTERS LA English DT Article ID GAAS/ALGAAS AB Gratings of different period spacings are fabricated on quantum well infrared photodetectors having two-stack multiple quantum wells (MQW) to determine the grating coupling efficiency in multicolor detection. The peak wavelength of each MQW is 4.8 and 9.4 mu m, respectively, covering the two atmospheric windows. 2D gratings of box-shaped cavities with grating period either in 3 or 4.6 mu m spacing are used to coupled normal incident light into the detector. Comparing detectors with and without gratings at either normal or 45 degrees facet incidence, the detectors with an optimized grating show efficient light coupling for both wavelengths due to the fact that the longer wavelength in the present case is an integral multiple of the shorter wavelength. The optimized long wavelength grating couples the shorter wavelength through additional higher orders of diffraction. (C) 1995 American Institute of Physics. C1 MARTIN MARIETTA CORP LABS,BALTIMORE,MD 21227. RP TIDROW, MZ (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. RI Choi, Kwong-Kit/K-9205-2013 NR 11 TC 30 Z9 31 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 25 PY 1995 VL 67 IS 13 BP 1800 EP 1802 DI 10.1063/1.115063 PG 3 WC Physics, Applied SC Physics GA RW225 UT WOS:A1995RW22500002 ER PT J AU CLAPP, LE KLETTE, KL DECOSTER, MA BERNTON, E PETRAS, JM DAVE, JR LASKOSKY, MS SMALLRIDGE, RC TORTELLA, FC AF CLAPP, LE KLETTE, KL DECOSTER, MA BERNTON, E PETRAS, JM DAVE, JR LASKOSKY, MS SMALLRIDGE, RC TORTELLA, FC TI PHOSPHOLIPASE A(2)-INDUCED NEUROTOXICITY IN-VITRO AND IN-VIVO IN RATS SO BRAIN RESEARCH LA English DT Article DE PHOSPHOLIPASE A(2); MELITTIN; NEUROTOXICITY; NEURONAL CULTURE; [CA2+](I) SEIZURE; RAT ID ACID RELEASE; GLUTAMATE; MELITTIN; NEURONS; PREVENTS; INFLUX; CELLS; VENOM AB The present study evaluated the neurotoxic potential of phospholipase A(2) (PLA(2)) in in vitro (primary neuronal cultures) and in vivo (EEG and behavior) rat models of CNS excitability. In vitro, PLA(2) (0.0038-5.8 nM) or melittin (a potent activator of endogenous PLA(2); 100-5000 nM), were highly neurotoxic, causing approximately 500 units/ml LDH release. The neurotoxic EC(50)s for PLA(2) and melittin were 1.8 (1.4-2.3) and 848 (501-1280) nM, respectively. Neurotoxic concentrations of PLA(2) stimulated neuronal release of [H-3]AA. Preliminary in vitro experiments evaluating changes in neuronal calcium flux indicated that PLA(2) caused transient, and melittin sustained, increases in [Ca2+](i). In vivo, PLA(2) (0.5-5 mu g i.c.v.) or melittin (2.5-20 mu g i.c.v.) produced nonconvulsive EEG seizures, which generalized to status epilepticus. While the onset of seizure development was markedly delayed for PLA(2) (1.5-4.5 h), the seizure inducing effects of melittin were evident within 3.5 +/- 0.2 min and more severe. Both PLA(2) and melittin were lethal, exhibiting LD(50)s of 0.62 mu g and 8.4 mu g, respectively. Pretreatment with(+)-MK801 (5 mu g, i.c.v.) significantly attenuated melittin, but not PLA(2), in vivo neurotoxicity. PLA(2) induced neuropathology in surviving rats revealed extensive cortical and subcortical injury to forebrain neurons and fibre pathways. Collectively, these results demonstrate the potent neurotoxic potential of PLA(2), the delayed clinical nature of its in vivo neurotoxicity and the applicability of these model systems to future studies on mechanisms of PLA(2) neurotoxicity and the development of potential PLA(2) antagonists. C1 WALTER REED ARMY INST RES,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DEPT MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,ALLERGY IMMUNOL SERV,WASHINGTON,DC 20307. NR 25 TC 26 Z9 28 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 J9 BRAIN RES JI Brain Res. PD SEP 25 PY 1995 VL 693 IS 1-2 BP 101 EP 111 DI 10.1016/0006-8993(95)00720-B PG 11 WC Neurosciences SC Neurosciences & Neurology GA RX133 UT WOS:A1995RX13300012 PM 8653397 ER PT J AU CHEICANTE, RL STUFF, JR DURST, HD AF CHEICANTE, RL STUFF, JR DURST, HD TI SEPARATION OF SULFUR-CONTAINING CHEMICAL WARFARE RELATED-COMPOUNDS IN AQUEOUS SAMPLES BY MICELLAR ELECTROKINETIC CHROMATOGRAPHY SO JOURNAL OF CHROMATOGRAPHY A LA English DT Note ID CAPILLARY ZONE ELECTROPHORESIS AB A method is described in which micellar electrokinetic chromatography (MEKC) is used to separate thiodiglycol, 2,2'-sulfinyldiethanol, 1,4-dithiane, 1,4-thioxane, O-isobutyl methylphosphonothioic acid and O-ethyl methylphosphonothioic acid in aqueous samples. Detection limits range from 1 to 10 mu g/ml and the calibration curves are linear over two orders of magnitude. The compounds are separated in under 10 min. The method fulfills our requirements for a rapid, on-site screening technique for these compounds. C1 EAI CORP,ABINGDON,MD 21009. USA,MAT COMMAND TREATY LAB,EDGEWOOD,MD 21005. NR 13 TC 29 Z9 29 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0021-9673 J9 J CHROMATOGR A JI J. Chromatogr. A PD SEP 22 PY 1995 VL 711 IS 2 BP 347 EP 352 DI 10.1016/0021-9673(95)00524-Q PG 6 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA RY346 UT WOS:A1995RY34600013 ER PT J AU NI, TD STURZEBECHER, D CUMMINGS, M PERLMAN, B AF NI, TD STURZEBECHER, D CUMMINGS, M PERLMAN, B TI DESIGN, FABRICATION, AND TEST OF WIDE-ANGLE LOW-LOSS Y-JUNCTION HYBRID POLYMER COUPLERS SO APPLIED PHYSICS LETTERS LA English DT Article ID WAVE-GUIDES; RADIATION LOSS; BENDS AB Optical couplers are key components for signal distribution in optoelectronic transmitter/receiver modules. A new low-loss large-angle Y-junction hybrid polymer optical coupler incorporating an integrated microprism has been fabricated and demonstrated experimentally for use in a mixed-signal module environment. The results show that the radiation loss is small with relatively wide branching angle as compared to a conventional Y-junction coupler. RP NI, TD (reprint author), USA,RES LAB,PHYS SCI DIRECTORATE,EB,PS,AMSRL,FT MONMOUTH,NJ 07703, USA. NR 10 TC 7 Z9 7 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 18 PY 1995 VL 67 IS 12 BP 1651 EP 1652 DI 10.1063/1.115045 PG 2 WC Physics, Applied SC Physics GA RV180 UT WOS:A1995RV18000005 ER PT J AU JIA, QX WU, XD FOLTYN, SR FINDIKOGLU, AT TIWARI, P ZHENG, JP JOW, TR AF JIA, QX WU, XD FOLTYN, SR FINDIKOGLU, AT TIWARI, P ZHENG, JP JOW, TR TI HETEROEPITAXIAL GROWTH OF HIGHLY CONDUCTIVE METAL-OXIDE RUO2 THIN-FILMS BY PULSED-LASER DEPOSITION SO APPLIED PHYSICS LETTERS LA English DT Article ID CHEMICAL-VAPOR-DEPOSITION; RUTHENIUM DIOXIDE; FATIGUE; IRO2 AB Highly conductive ruthenium oxide (RuO2) has been epitaxially grown on LaAlO3 substrates by pulsed laser deposition. The RuO2 film is (hOO) oriented normal to the substrate surface. The heteroepitaxial growth of RuO2 on LaAlO3 is demonstrated by the strong in-plane orientation of thin films with respect to the major axes of the substrate. High crystallinity of RuO2 thin films is also determined from Rutherford backscattering channeling measurements. Electrical measurements on the RuO2 thin films demonstrate a quite low room-temperature resistivity of 35+/-2 mu Omega cm at deposition temperatures of above 500 degrees C. (C) 1995 American Institute of Physics. C1 USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703. RP JIA, QX (reprint author), LOS ALAMOS NATL LAB,CTR SUPERCONDUCT TECHNOL,LOS ALAMOS,NM 87545, USA. RI Jia, Q. X./C-5194-2008 NR 22 TC 33 Z9 33 U1 0 U2 4 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 18 PY 1995 VL 67 IS 12 BP 1677 EP 1679 DI 10.1063/1.115054 PG 3 WC Physics, Applied SC Physics GA RV180 UT WOS:A1995RV18000014 ER PT J AU NABET, B YOUTZ, A CASTRO, F COOKE, P PAOLELLA, A AF NABET, B YOUTZ, A CASTRO, F COOKE, P PAOLELLA, A TI CURRENT TRANSPORT IN AS-GROWN AND ANNEALED INTERMEDIATE TEMPERATURE MOLECULAR-BEAM EPITAXY-GROWN GAAS SO APPLIED PHYSICS LETTERS LA English DT Article ID MBE AB Molecular beam epitaxy (MBE) GaAs grown in the intermediate temperature range of about 400 degrees C may provide combination of low lifetime, high resistivity, and high mobility. We compare current conduction in unannealed and annealed material grown at 400 degrees C by fabricating photodetectors on substrates grown between temperature ranges of 250-500 degrees C. The unannealed version of the device grown at 400 degrees C shows substantial difference of conduction properties in dark and under light. It is shown that while at low biases the unannealed material may be semi-insulating, at high biases more current is conducted than in annealed material. We attribute this to the effect of intergap states on current conduction and suggest that defect state assisted tunneling is the dominant current transport mechanism in these ranges. Quenching of response by light suggests that occupancy of traps can eliminate their role in current conduction. (C) 1995 American Institute of Physics. C1 USA,RES LAB,EPSD DIRECTORATE,FT MONMOUTH,NJ 07703. RP NABET, B (reprint author), DREXEL UNIV,DEPT ELECT & COMP ENGN,PHILADELPHIA,PA 19104, USA. NR 14 TC 9 Z9 9 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 18 PY 1995 VL 67 IS 12 BP 1748 EP 1750 DI 10.1063/1.115037 PG 3 WC Physics, Applied SC Physics GA RV180 UT WOS:A1995RV18000038 ER PT J AU MORRISON, PW SOMASHEKHAR, A GLASS, JT PRATER, JT AF MORRISON, PW SOMASHEKHAR, A GLASS, JT PRATER, JT TI GROWTH OF DIAMOND FILMS USING AN ENCLOSED COMBUSTION-FLAME SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID CHEMICAL-VAPOR-DEPOSITION; OXYGEN-ACETYLENE FLAMES; RAMAN-SPECTROSCOPY; CRYSTAL-GROWTH; SCALING LAWS; NUCLEATION AB This paper discusses the growth of diamond thin films using an enclosed oxyacetylene torch operating at 700 Torr. Using response surface methodologies, we have systematically explored the parameter space to construct maps of nucleation density, film quality, growth rate, and orientational texture as functions of conditions. The deposition process has been broken down into a nucleation enhancement step and a growth step, and each step is optimized separately. In the study of the nucleation enhancement, we vary the flow ratio=O-2/C2H2 (R), substrate-flame distance (z), and pretreatment time (t) while holding substrate temperature (T-sub) less than or equal to 550 degrees C and flow rate (F)=4 slm. Scanning electron microscopy determines the nucleation density and nucleation uniformity. The best nucleation enhancement occurs at R=0.91, z=50% of the feather length, and t=5 minutes. For the growth study, the variables are R, z, and T-sub (F=4 slm), and we employ two different Raman scattering measurements to assess film quality. In one case, we determine quality using the quality fraction=diamond peak/(diamond peak + nondiamond peak); the second indicator is the luminescence (L) determined from the baseline of the spectrum and is related to defects in the film. The highest quality films appear at high R (0.95-0.97), z=1 mm, and high T-sub (900-1000 degrees C). We have also determined the growth rate as a function of conditions using infrared spectroscopy and find that the growth rate is a factor of 10 less than in the unenclosed flame (i.e., open to the atmosphere). Films grown for one hour show orientational texturing predominantly in the [111] direction. (C) 1995 American Institute of Physics. C1 N CAROLINA STATE UNIV, DEPT MAT SCI & ENGN, RALEIGH, NC 27695 USA. USA, RES OFF, DIV MAT SCI, RES TRIANGLE PK, NC 27709 USA. RI Glass, Jeffrey/A-2266-2010 OI Glass, Jeffrey/0000-0002-9554-4398 NR 45 TC 17 Z9 17 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 15 PY 1995 VL 78 IS 6 BP 4144 EP 4156 DI 10.1063/1.359874 PG 13 WC Physics, Applied SC Physics GA RU953 UT WOS:A1995RU95300088 ER PT J AU JOHNSON, JB AF JOHNSON, JB TI EQUATION OF STATE FOR EXTRAPOLATION OF HIGH-PRESSURE SHOCK HUGONIOT DATA - COMMENT SO JOURNAL OF APPLIED PHYSICS LA English DT Note AB Oh and Persson [J. Appl. Phys. 65, 3852 (1989)] proposed an equation of state to extrapolate high-pressure shock Hugoniot data to other high-pressure and high-temperature states and compared it to data. The requirement that F=-(partial derivative E/partial derivative V)(p)/(partial derivative E/partial derivative V)(H) approximate to 1 (E is specific internal energy, V is specific volume, P is the constant pressure path and H is the constant Hugoniot path) needed to establish the equation of state appears to be in error. I have found F to vary from 0.16 to 3.59 for fifteen common materials of interest to shock physicists. Oh and Persson's [J. Appl. Phys. 65, 3852 (1989)] comparison of their equation of state to data gives the impression of a better agreement than actually occurs because of possible errors in the transcription of data, and the use of an inappropriate Hugoniot for water. When data are correctly plotted and an appropriate water Hugoniot is used, the comparison of data to theory indicates that the equation of state loses accuracy with increasing pressure or decreasing porous initial density. RP JOHNSON, JB (reprint author), USA,COLD REG RES & ENGN LAB,POB 35170,FT WAINWRIGHT,AK 99703, USA. NR 10 TC 2 Z9 2 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 15 PY 1995 VL 78 IS 6 BP 4300 EP 4302 DI 10.1063/1.359833 PG 3 WC Physics, Applied SC Physics GA RU953 UT WOS:A1995RU95300117 ER PT J AU BURGESS, EB AF BURGESS, EB TI PANAMA - ZENCEY,E SO LIBRARY JOURNAL LA English DT Book Review RP BURGESS, EB (reprint author), USA,COMBINED ARMS RES LIB,FT LEAVENWORTH,KS 66027, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD SEP 15 PY 1995 VL 120 IS 15 BP 95 EP 95 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RU365 UT WOS:A1995RU36500195 ER PT J AU DAVIS, NL BROWN, KW GREENWALD, GF ZAJAC, AJ ZACNY, VL SMITH, JF JOHNSTON, RE AF DAVIS, NL BROWN, KW GREENWALD, GF ZAJAC, AJ ZACNY, VL SMITH, JF JOHNSTON, RE TI ATTENUATED MUTANTS OF VENEZUELAN EQUINE ENCEPHALITIS-VIRUS CONTAINING LETHAL MUTATIONS IN THE PE2 CLEAVAGE SIGNAL COMBINED WITH A 2ND-SITE SUPPRESSOR MUTATION IN E1 SO VIROLOGY LA English DT Article ID SEMLIKI FOREST VIRUS; PSEUDOMONAS EXOTOXIN-A; TRINIDAD DONKEY STRAIN; SINDBIS VIRUS; STRUCTURAL PROTEINS; MEMBRANE-PROTEINS; VERTEBRATE CELLS; SPIKE PROTEIN; CDNA CLONE; LOW PH AB The PE2 cleavage signal in a full-length cDNA clone of the alphavirus Venezuelan equine encephalitis virus (VEE) was ablated by site-directed mutagenesis. RNA transcripts derived from the resulting plasmids programmed the production of nonviable particles upon transfection of baby hamster kidney (BHK) cells. However, the mutant RNAs also gave rise to a smalt proportion of viable revertants. Analysis of these biological revertants and their molecularly cloned homologs demonstrated that second-site suppressor mutations at either E2 position 243 or E1 position 253 were able to restore viability to PE2 cleavage signal mutants. The viable revertants incorporated unprocessed PE2 into particles which showed normal infectivity for BHK cells, but reduced ability to grow in C6/36 mosquito cells. A mutant carrying a lethal PE2 cleavage signal mutation in combination with a suppressor at El 253 was either avirulent or highly attenuated in adult mice when inoculated by the subcutaneous, intracerebral, or intranasal route and conferred complete protection against both intraperitoneal and intranasal challenge with virulent VEE. These results indicate the close functional association of the E2 and E1 proteins in the alphavirus spike. They also have implications for the design of recombinant live virus Vaccines for VEE, for other alphaviruses, and for other viruses that use a similar mechanism for glycoprotein maturation. (C) 1995 Academic Press, Inc. C1 USA,INFECT DIS RES INST,DIV VIROL,FREDERICK,MD 21702. RP DAVIS, NL (reprint author), UNIV N CAROLINA,DEPT MICROBIOL & IMMUNOL,BOX 7290,CHAPEL HILL,NC 27599, USA. FU NIAID NIH HHS [AI22186]; NINDS NIH HHS [NS26681] NR 45 TC 86 Z9 88 U1 0 U2 2 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD SEP 10 PY 1995 VL 212 IS 1 BP 102 EP 110 DI 10.1006/viro.1995.1458 PG 9 WC Virology SC Virology GA RV178 UT WOS:A1995RV17800012 PM 7676619 ER PT J AU JONES, CR KOSAI, H DUTTA, JM PETERS, MJ GUO, W DELUCIA, FC BENSON, SV MADEY, JMJ SWARTZ, JC GUENTHER, BD AF JONES, CR KOSAI, H DUTTA, JM PETERS, MJ GUO, W DELUCIA, FC BENSON, SV MADEY, JMJ SWARTZ, JC GUENTHER, BD TI GENERATION OF PICOSECOND PULSES AT MILLIMETER WAVELENGTHS SO APPLIED PHYSICS LETTERS LA English DT Article AB We report here on an experiment in which picosecond electron pulses, produced by a compact radiation frequency (rf) electron gun, were used to excite a rectangular waveguide, generating 5 ps pulses of radiation with a bandwidth of similar to 200 GHz. The interaction of the electron pulses with the waveguide can be modeled quite simply by performing a harmonic expansion of the pulse train produced by the electron gun and employing Poynting's theorem to compute the power coupled into the modes of the waveguide by each harmonic. The resulting model for the distribution of spectral power yields good agreement with the observed spectrum. (C) 1995 American Institute of Physics. C1 OHIO STATE UNIV,DEPT PHYS,COLUMBUS,OH 43210. DUKE UNIV,DEPT PHYS,DURHAM,NC 27708. USA,RES OFF,DIV PHYS,RES TRIANGLE PK,NC 27709. RP JONES, CR (reprint author), N CAROLINA CENT UNIV,DEPT PHYS,DURHAM,NC 27707, USA. NR 6 TC 3 Z9 3 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 4 PY 1995 VL 67 IS 10 BP 1483 EP 1485 DI 10.1063/1.114502 PG 3 WC Physics, Applied SC Physics GA RR440 UT WOS:A1995RR44000048 ER PT J AU MASON, CJ MARKOWITZ, LE KITSIRIPORNCHAI, S JUGSUDEE, A SIRISOPANA, N TORUGSA, K CARR, JK MICHAEL, RA NITAYAPHAN, S MCNEIL, JG AF MASON, CJ MARKOWITZ, LE KITSIRIPORNCHAI, S JUGSUDEE, A SIRISOPANA, N TORUGSA, K CARR, JK MICHAEL, RA NITAYAPHAN, S MCNEIL, JG TI DECLINING PREVALENCE OF HIV-1 INFECTION IN YOUNG THAI MEN SO AIDS LA English DT Article DE EPIDEMIOLOGY; ASIA; HIV SEROPREVALENCE; THAILAND; MILITARY PERSONNEL ID NORTHERN THAILAND; VACCINE TRIALS; BISEXUAL MEN AB Objective: To evaluate trends in HIV-1 seroprevalence in Thailand. Design: HIV-1 serosurvey of successive cohorts of young Thai men entering service with the Royal Thai Army (RTA) between November 1989 and November 1994. Methods: In November 1989, the RTA Medical Department began routine HIV-1-antibody screening of men who were selected by lottery for conscription. Between November 1989 and November 1994, 311 108 young men were screened at induction. Demographic data were collected between November 1991 and May 1993 and again in November 1994. Results: The seroprevalence of HIV-1 among conscripts nationwide increased rapidly from 0.5% in 1989 to 3.5% in 1992 and reached 3.7% in 1993. In 1994, the overall prevalence decreased to 3.0%. The decrease was greatest in the upper North (from 12.4% in 1992 to 7.9% in 1994), where the prevalence has been the highest. However, decreases were observed in men from all regions of residence in the country, from both rural and urban areas, and at all educational levels. Conclusions: The decline in prevalence suggests declining incidence and that HIV control programs in Thailand are having an impact on the HIV epidemic. C1 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,BALTIMORE,MD. ARMY INST PATHOL,BANGKOK,THAILAND. HENRY M JACKSON SCH INT STUDIES,ROCKVILLE,MD. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. RP MASON, CJ (reprint author), ARMED FORCES RES INST MED SCI,315-6 RAJVITHI RD,BANGKOK 10400,THAILAND. OI MASON, CARL/0000-0002-3676-2811 NR 21 TC 70 Z9 71 U1 0 U2 0 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0269-9370 J9 AIDS JI Aids PD SEP PY 1995 VL 9 IS 9 BP 1061 EP 1065 DI 10.1097/00002030-199509000-00012 PG 5 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA RU013 UT WOS:A1995RU01300012 PM 8527079 ER PT J AU CELENTANO, DD BEYRER, C NATPRATAN, C EIUMTRAKUL, S SUSSMAN, L RENZULLO, PO KHAMBOONRUANG, C NELSON, KE AF CELENTANO, DD BEYRER, C NATPRATAN, C EIUMTRAKUL, S SUSSMAN, L RENZULLO, PO KHAMBOONRUANG, C NELSON, KE TI WILLINGNESS TO PARTICIPATE IN AIDS VACCINE TRIALS AMONG HIGH-RISK POPULATIONS IN NORTHERN THAILAND SO AIDS LA English DT Article DE AIDS VACCINES; THAILAND; HUMAN VOLUNTEERS; PROPHYLACTIC TRIALS; RISK FACTORS; PROSTITUTION; HIV/AIDS; SEXUALLY TRANSMITTED DISEASES ID INFECTION; MEN; HIV AB Objectives: To determine the anticipated participation in a prophylactic AIDS vaccine trial and to identify perceived benefits and barriers to enrollment of HIV-seronegative volunteers at risk of HIV infection in northern Thailand. Design: A cross-sectional survey. Methods: Subjects interviewed in a cross-sectional survey included female commercial sex workers (n=215), men attending sexually transmitted disease clinics (n=219), conscripts in the Royal Thai Army (n=1453), and men discharged from the army (n=293) who had returned to civilian life. We determined AIDS vaccine knowledge and attitudes, perceived vulnerability to HIV infection, barriers and incentives to participate in a future vaccine trial and agreement to participate in a randomized trial. Results: Awareness of vaccines (88-97%) and AIDS vaccine development efforts (62-77%) were common and viewed to be a complement to behavior change (74-94%). Approximately 25% of subjects would definitely join a trial if asked, and an additional 38% would accept an AIDS vaccine if they were convinced it would be safe and effective. Important barriers to participation included concerns with discrimination (16-45%), short- (37-60%) and long-term (30-55%) vaccine side-effects, fear of disability and death (36-58%), and beliefs that partners would refuse to have sex (24-49%) after immunization. The principal inducement to join a trial was health insurance (62%). Conclusion: Potential HIV vaccine trial participants have several fears of joining a vaccine study at this time. Information derived from Phase I/II trials is needed to address these concerns if enrollment in efficacy trials is to be successful in the near future. C1 ROYAL THAI MINIST PUBL HLTH,DEPT COMMUNICABLE DIS CONTROL,CHIANG MAI,THAILAND. KAWILA HOSP,ROYAL THAI ARMY MED CORPS,CHIANG MAI,THAILAND. WALTER REED ARMY INST RES,WASHINGTON,DC. CHIANG MAI UNIV,HLTH SCI RES INST,CHIANG MAI 50000,THAILAND. RP CELENTANO, DD (reprint author), JOHNS HOPKINS MED INST,SCH HYG & PUBL HLTH,FAC SOCIAL & BEHAV SCI,624 N BROADWAY,BALTIMORE,MD 21205, USA. FU NIAID NIH HHS [AI33863] NR 33 TC 47 Z9 49 U1 0 U2 2 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0269-9370 J9 AIDS JI Aids PD SEP PY 1995 VL 9 IS 9 BP 1079 EP 1083 DI 10.1097/00002030-199509000-00015 PG 5 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA RU013 UT WOS:A1995RU01300015 PM 8527082 ER PT J AU BOAM, WD MISER, WF AF BOAM, WD MISER, WF TI ACUTE FOCAL BACTERIAL PYELONEPHRITIS SO AMERICAN FAMILY PHYSICIAN LA English DT Article AB Acute focal bacterial pyelonephritis is a renal inflammatory disease that has similarities to both pyelonephritis and renal abscess. The diagnosis is based on clinical symptoms of pyelonephritis and renal abnormalities detected on radiologic imaging studies (ultrasonography and computed tomographic scanning). Ultrasonographic examination demonstrates mass lesions in the renal cortex that resolve after appropriate antibiotic therapy. Computed tomographic studies reveal localized, wedge-shaped or circular, poorly enhancing, hypodense areas and/or swelling of the superior pole of the kidney. A voiding cystourethrogram should be done to rule out reflux as an underlying cause. Magnetic resonance imaging is not required for diagnosis or follow-up evaluation. Escherichia coli is the most common etiologic agent. All reported cases have responded to conservative therapy with extended courses of oral bactericidal antibiotics. Resolution is typically complete in one to three months. A follow-up evaluation with ultrasonography is required to document resolution. RP BOAM, WD (reprint author), US MIL ACAD,KELLER ARMY COMMUNITY HOSP,W POINT,NY 10996, USA. RI Miser, William/E-3686-2011 NR 0 TC 12 Z9 12 U1 0 U2 1 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD SEP 1 PY 1995 VL 52 IS 3 BP 919 EP 924 PG 6 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA RT932 UT WOS:A1995RT93200019 PM 7653429 ER PT J AU PHELPS, JY HIGBY, H SMYTH, MH WARD, JA ARREDONDO, F MAYER, AR AF PHELPS, JY HIGBY, H SMYTH, MH WARD, JA ARREDONDO, F MAYER, AR TI ACCURACY AND INTRAOBSERVER VARIABILITY OF SIMULATED CERVICAL DILATATION MEASUREMENTS SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE CERVICAL DILATATION; CERVICAL MEASUREMENTS; LABOR AB OBJECTIVE: Our purpose was to assess the accuracy and intraobserver variability of clinical cervical diameter measurements among obstetric health care providers. STUDY DESIGN: Polyvinyl chloride pipes 1 to 10 cm in diameter were mounted in cardboard boxes and used to simulate cervical examinations. The boxes were designed so that the examiner had to rely solely on proprioception to determine the inner diameter. RESULTS: A total of 1574 simulated cervical diameter measurements were obtained from 102 different examiners in a two-part study. The overall accuracy for determining the exact diameter was 56.3%, which improved to 89.5% when an error of ii cm was allowed. Intraobserver variability for a given diameter measurement was 52.1%, which decreased to 10.5% when an error of +/- 1 cm was allowed. CONCLUSIONS: Cervical diameter measurements obtained by digital examination are precise when an error of +/- 1 cm is allowed for. Intraobserver variability is > 50% and is an important consideration when evaluating dysfunctional labor. C1 UNIV TEXAS,MED CTR HOSP,SAN ANTONIO,TX. BROOKE ARMY MED CTR,DEPT OBSTET & GYNECOL,SAN ANTONIO,TX. NR 9 TC 54 Z9 55 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD SEP PY 1995 VL 173 IS 3 BP 942 EP 945 DI 10.1016/0002-9378(95)90371-2 PN 1 PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA RX497 UT WOS:A1995RX49700050 PM 7573274 ER PT J AU RUMANS, TM JONES, M RAMIREZ, SG AF RUMANS, TM JONES, M RAMIREZ, SG TI FUNGAL SINUSITIS PRESENTING AS AN ETHMOID MUCOCELE SO AMERICAN JOURNAL OF RHINOLOGY LA English DT Article AB Fungal sinusitis was first reported in the late 1880s and was due to Aspergillus. Since this initial report, scattered case reports of fungal sinusitis have appeared in the medical literature, with the majority of these cases being due to Aspergillus and Mucormycosis. These case reports have also demonstrated multiple presentations of fungal sinusitis; however, our review of the literature did not demonstrate any previous case reports presenting as an ethmoid sinus mucocele. We now describe what we believe to be the first case of fungal sinusitis that presented as an ethmoid sinus mucocele. C1 DWIGHT DAVID EISENHOWER MED CTR,OTOLARYNGOL HEAD & NECK SURG SERV,FT GORDON,GA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU OCEAN SIDE PUBLICATIONS INC PI PROVIDENCE PA 95 PITMAN ST, PROVIDENCE, RI 02906 SN 1050-6586 J9 AM J RHINOL JI Am. J. Rhinol. PD SEP-OCT PY 1995 VL 9 IS 5 BP 247 EP 249 DI 10.2500/105065895781808874 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA TF581 UT WOS:A1995TF58100002 ER PT J AU MARINER, JC MORRILL, J KSIAZEK, TG AF MARINER, JC MORRILL, J KSIAZEK, TG TI ANTIBODIES TO HEMORRHAGIC-FEVER VIRUSES IN DOMESTIC LIVESTOCK IN NIGER - RIFT-VALLEY FEVER AND CRIMEAN-CONGO HEMORRHAGIC-FEVER SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID IMMUNOGLOBULIN-M ANTIBODIES; LINKED IMMUNOSORBENT-ASSAY; MAURITANIA; EPIDEMIC; PHLEBOVIRUSES; TRANSMISSION; SEROSURVEY; INFECTION; CATTLE; SHEEP AB A repository of domestic animal sera collected in Niger between 1984 and 1988 was assayed for antibody against two zoonotic hemorrhagic fever viruses known to be present in the West African Sahel. A total of 2,540 serum samples from 2,324 cattle, sheep, goats, and camels were tested by an IgG-specific enzyme-linked immunosorbent assay (ELISA) and the 80% plaque reduction neutralization test (PRNT(80)) for Rift Valley fever (RVF) virus antibody. Of the 2,540 sera tested for RVF-specific IgG antibody, 1,676 sera from cattle, sheep, and goats were examined for RVF-specific IgM antibody by ELISA. A subset of 2,263 sera were examined for evidence of Crimean-Congo hemorrhagic fever (CCHF) virus antibody by an IgG-specific ELISA. Antibody against CCHF virus was found to be most prevalent in adult cattle (422 of 732 or 57.7% positive) sampled at nine locations in the Niamey area. The highest prevalence for RVF neutralizing antibodies was found in camels from the Agadez Department with 67 (47.5%) of 141 positive. The results indicate that both CCHF and RVF Viruses are circulating in Niger and are potential zoonotic health risks. C1 RDP LIVESTOCK SERV,ZEIST,NETHERLANDS. CTR DIS CONTROL & PREVENT,DIV VIRAL & RICKETTSIAL DIS,SPECIAL PATHOGENS BRANCH,ATLANTA,GA 30333. TUFTS UNIV,SCH VET MED,N GRAFTON,MA 01536. USA,MED RES INST INFECT DIS,DIV APPL RES,FREDERICK,MD 21702. NR 31 TC 19 Z9 20 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD SEP PY 1995 VL 53 IS 3 BP 217 EP 221 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA RY073 UT WOS:A1995RY07300001 PM 7573699 ER PT J AU CLAYSON, ET INNIS, BL MYINT, KSA NARUPITI, S VAUGHN, DW GIRI, S RANABHAT, P SHRESTHA, MP AF CLAYSON, ET INNIS, BL MYINT, KSA NARUPITI, S VAUGHN, DW GIRI, S RANABHAT, P SHRESTHA, MP TI DETECTION OF HEPATITIS-E VIRUS-INFECTIONS AMONG DOMESTIC SWINE IN THE KATHMANDU VALLEY OF NEPAL SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID NON-B HEPATITIS; EPIDEMIC NON-A; VIRAL-HEPATITIS; TRANSMISSION AB The prevalence of hepatitis E virus (HEV) infections among 55 domestic swine living in the Kathmandu Valley of Nepal was investigated. Sera and stool specimens were collected from 47 free-roaming swine and examined for the presence of HEV genomic sequences by the reverse transcription-polymerase chain reaction. Sera from these animals, as well as sera from eight other swine, were also examined for the presence of HEV-specific antibodies by an enzyme-linked immunosorbent assay and by a fluorescent antibody blocking assay. Hepatitis E virus RNA was detected in the sera and/or stool of three of 47 swine, while HEV-specific antibodies were detected in 18 of 55 swine. These results indicate that HEV is a zoonotic virus, and that swine are among its natural hosts. C1 WALTER REED ARMY INST RES, DEPT VIRUS DIS, WASHINGTON, DC 20307 USA. INFECT DIS HOSP, KATMANDU, NEPAL. USA MED COMPONENT, ARMED FORCES RES INST MED SCI, DEPT VIROL, BANGKOK, THAILAND. NR 24 TC 131 Z9 138 U1 0 U2 5 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD SEP PY 1995 VL 53 IS 3 BP 228 EP 232 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA RY073 UT WOS:A1995RY07300003 PM 7573701 ER PT J AU KONISHI, E KURANE, I MASON, PW INNIS, BL ENNIS, FA AF KONISHI, E KURANE, I MASON, PW INNIS, BL ENNIS, FA TI JAPANESE ENCEPHALITIS VIRUS-SPECIFIC PROLIFERATIVE RESPONSES OF HUMAN PERIPHERAL-BLOOD T-LYMPHOCYTES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID INTERFERON GAMMA-PRODUCTION; LETHAL JEV INFECTION; CELL RESPONSES; CEREBROSPINAL-FLUID; ANTIBODY-RESPONSE; FLAVIVIRUS KUNJIN; E-GLYCOPROTEIN; DENGUE; EXPRESSION; PROTEINS AB The T lymphocytes play an important role in prevention and recovery from viral infections. To characterize T lymphocyte responses to Japanese encephalitis (JE) virus infections, we analyzed JE virus-specific T lymphocytes in peripheral blood mononuclear cells (PBMC) obtained from seven JE patients and 10 vaccinees who had received a formalin-inactivated, purified JE virus vaccine (Biken vaccine). These PBMC were examined for proliferative responses against live JE virus, a glutaraldehyde-fixed lysate of cells infected with JE virus, and extracellular particles (EPs; subviral membrane vesicles released from cells infected with recombinant vaccinia viruses encoding the JE virus premembrane and envelope proteins). Japanese encephalitis virus-specific T cell proliferation was demonstrated with PBMC from both patients and vaccinees after stimulation with infectious JE virus or the lysate of JE virus-infected cells. Proliferating PBMC included CD4(+) T lymphocytes and CD8(+) T lymphocytes in responses to either form of JE viral antigens. Responses to EPs were observed only with PBMC from some American vaccinees whose PBMC also responded to the virus and lysate. These results indicate that JE virus infection and immunization with an inactivated JE vaccine induce JE virus-specific CD4(+) and CD8(+) T memory lymphocytes that can be induced to proliferate by infectious JE virus and noninfectious JE antigens. C1 UNIV MASSACHUSETTS,MED CTR,DEPT MED,DIV INFECT DIS & IMMUNOL,WORCESTER,MA 01655. USDA ARS,PLUM ISL ANIM DIS CTR,GREENPORT,NY 11944. WALTER REED ARMY INST RES,DEPT VIRAL DIS,WASHINGTON,DC 20307. ARMED FORCES RES INST MED SCI,DEPT VIROL,BANGKOK,THAILAND. RP KONISHI, E (reprint author), KOBE UNIV,SCH MED,DEPT MED ZOOL,CHUO KU,7-5-1 KUSUNOKI CHO,KOBE 650,JAPAN. FU NIAID NIH HHS [AI-10987-17, R01-AI-30624] NR 30 TC 30 Z9 32 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD SEP PY 1995 VL 53 IS 3 BP 278 EP 283 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA RY073 UT WOS:A1995RY07300015 PM 7573713 ER PT J AU STOLTZFUS, DP WATSON, CB RIES, MC AF STOLTZFUS, DP WATSON, CB RIES, MC TI ANESTHESIOLOGY CRITICAL CARE MEDICINE FELLOWSHIP TRAINING SO ANESTHESIA AND ANALGESIA LA English DT Article AB Anesthesiology critical care medicine (ACCM) fellowship training was accredited in 1989, and a small number of graduating anesthesiology residents pursue this additional training. Considering the flexible program guidelines of the American Board of Anesthesiology (ABA), we hypothesized that ACCM fellowship training programs varied significantly among the 42 institutions accredited to offer this program. This study of ACCM fellowship programs used a six-part, 57-item questionnaire completed by 36 program directors to describe six aspects of the program: institution size, program director, attending staff, fellowship applicants, curriculum, and the role of the American Society of Critical Care Anesthesiologists (ASCCA). Ninety-four percent of ACCM fellowships are in facilities with more than 400 beds; 81% of these institutions have more than 20 intensive care unit (ICU) beds as the basis for fellowship teaching. Eighty-three percent of ACCM program directors have practiced critical care for more than 5 yr. All programs had more than one attending physician, with the majority having a multidisciplinary attending staff. During two academic years (1990-1992), 12 (33%) of 36 programs did not have a fellow, resulting in an average of less than one fellow for each program. ACCM fellow involvement in patient care was characterized as ''primary'' in medical and pediatric ICUs and ''cooperative'' in surgical ICUs. Fellowship curricula had varied requirements for research, intraoperative anesthesia, and ICU procedures performed by the fellow. In general, program directors believe that salary and on-call responsibility are not important issues for applicants. Nineteen percent of program directors train ACCM fellows longer than the 12 mo required by the ABA and believe that ACCM training should be lengthened. C1 VET ADM MED CTR,GAINESVILLE,FL 32602. BRIDGEPORT HOSP,BRIDGEPORT,CT. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP STOLTZFUS, DP (reprint author), UNIV FLORIDA,COLL MED,DEPT ANESTHESIOL,EDITORIAL OFF,POB 100254 JHMHC,GAINESVILLE,FL 32610, USA. NR 3 TC 10 Z9 10 U1 1 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD SEP PY 1995 VL 81 IS 3 BP 441 EP 445 DI 10.1097/00000539-199509000-00002 PG 5 WC Anesthesiology SC Anesthesiology GA RR780 UT WOS:A1995RR78000002 PM 7653801 ER PT J AU BROWN, RS MONGAN, PD AF BROWN, RS MONGAN, PD TI HEMOCHRON ONSITE COAGULATION MONITORING (HC) AS A PREDICTOR OF BLEEDING IN CARDIOPULMONARY BYPASS (CP) PATIENTS SO ANESTHESIOLOGY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,ANESTHESIA SVCS,SAN ANTONIO,TX 78234. BROOKE ARMY MED CTR,OPERAT SVCS,SAN ANTONIO,TX 78234. NR 3 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD SEP PY 1995 VL 83 IS 3A SU S BP A96 EP A96 PG 1 WC Anesthesiology SC Anesthesiology GA RX685 UT WOS:A1995RX68500096 ER PT J AU BROWN, RS THWAITES, BK MONGAN, PD BOUSKA, GW AF BROWN, RS THWAITES, BK MONGAN, PD BOUSKA, GW TI APROTONIN (AP) OFFERS NO ADVANTAGE OVER TRANEXAMIC ACID (TA) IN HIGH-RISK CARDIAC-SURGERY SO ANESTHESIOLOGY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,ANESTHESIA SERV,SAN ANTONIO,TX. BROOKE ARMY MED CTR,OPERAT SERV,SAN ANTONIO,TX. NR 3 TC 1 Z9 2 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD SEP PY 1995 VL 83 IS 3A SU S BP A97 EP A97 PG 1 WC Anesthesiology SC Anesthesiology GA RX685 UT WOS:A1995RX68500097 ER PT J AU GREILICH, P ALVING, B HEALEY, P CHANG, A ONEILL, K REID, T AF GREILICH, P ALVING, B HEALEY, P CHANG, A ONEILL, K REID, T TI MONITORING THE ANTIPLATELET EFFECTS OF C7E3 FAB (REOPRO(TM)) IN HEPARINIZED SURGICAL PATIENTS SO ANESTHESIOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT ANESTHESIOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT HEMATOL & VASC BIOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 4 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD SEP PY 1995 VL 83 IS 3A SU S BP A98 EP A98 PG 1 WC Anesthesiology SC Anesthesiology GA RX685 UT WOS:A1995RX68500098 ER PT J AU STEVENS, JB SHEPHERD, JM VORIES, PA WALKER, SC VESCOVO, MV AF STEVENS, JB SHEPHERD, JM VORIES, PA WALKER, SC VESCOVO, MV TI RAPID-SEQUENCE INDUCTION OF ANESTHESIA WITH A COMBINATION OF ROCURONIUM AND MIVACURIUM SO ANESTHESIOLOGY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,ANESTHESIA & OPERAT SERV,SAN ANTONIO,TX 78234. NR 2 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD SEP PY 1995 VL 83 IS 3A SU S BP A912 EP A912 PG 1 WC Anesthesiology SC Anesthesiology GA RX685 UT WOS:A1995RX68500912 ER PT J AU THWAITES, BK BOUSKA, G NIGUS, DB MONGAN, PD AF THWAITES, BK BOUSKA, G NIGUS, DB MONGAN, PD TI PLATELET-FUNCTION DURING SPINAL-ANESTHESIA AND SURGERY BEFORE AND AFTER IV KETOROLAC SO ANESTHESIOLOGY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,ANESTHESIA SERV,FT SAM HOUSTON,TX 78234. NR 2 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD SEP PY 1995 VL 83 IS 3A SU S BP A785 EP A785 PG 1 WC Anesthesiology SC Anesthesiology GA RX685 UT WOS:A1995RX68500785 ER PT J AU ASHTON, WS DEGNAN, BM DANIEL, A FRANCIS, GL AF ASHTON, WS DEGNAN, BM DANIEL, A FRANCIS, GL TI TESTOSTERONE INCREASES INSULIN-LIKE GROWTH-FACTOR-I AND INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN SO ANNALS OF CLINICAL AND LABORATORY SCIENCE LA English DT Article ID CULTURED HUMAN-FIBROBLASTS; FACTOR-I; HORMONE DEFICIENCY; IGF-BINDING; RECEPTOR; AGE AB Growth of the male external genitalia is primarily regulated by androgens; however, several observations suggest growth hormone (GH) or a GH dependent factor, such as insulin-like growth factor-1 (IGF-1), might also be involved. It is hypothesized that testosterone (T) might induce the synthesis of IGF-1 or IGF-binding protein (IGF-BP) which could affect cell proliferation. This was evaluated by determining the effect of T on thymidine incorporation, cell surface IGF-1 binding, and the production of ICF-1 and ICF-BP by cultured neonatal foreskin fibroblasts. Testosterone significantly increased thymidine incorporation and the production of IGF-1 and IGF-BP (p < 0.05 vs control). However, T significantly decreased the cell surface binding of IGF-1 (p < 0.0001 vs control). To determine whether or not the increase in IGF-1 production was important in mediating the effect of T on thymidine incorporation, cells were incubated with either anti-ICF-1 antibody (anti-IGF-1), anti-IGF-1-receptor antibody (IGF-1-R-Ab), or a non-specific control antibody (NS-Ab). Anti-IGF-1 significantly decreased thymidine incorporation in both control cultures and those containing T. In addition, IGF-1-R-Ab blocked the expected T dependent increase in thymidine incorporation, while NS-Ab had no effect. These in vitro observations suggest both T and IGF-1 affect neonatal foreskin fibroblasts in a complex relationship. In addition, these data suggest T might stimulate foreskin fibroblast proliferation, at least in part, by changing the balance in production and effects of IGF-1 and IGF-BP. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. NR 16 TC 18 Z9 18 U1 0 U2 1 PU INST CLINICAL SCIENCE INC PI PHILADELPHIA PA 1833 DELANCEY PLACE, PHILADELPHIA, PA 19103 SN 0091-7370 J9 ANN CLIN LAB SCI JI Ann. Clin. Lab. Sci. PD SEP-OCT PY 1995 VL 25 IS 5 BP 381 EP 388 PG 8 WC Medical Laboratory Technology SC Medical Laboratory Technology GA RQ960 UT WOS:A1995RQ96000002 PM 7486812 ER PT J AU MARSELLA, RC BUCKNER, SB BRATTHAUER, GL OCONNOR, DM OLEARY, TJ AF MARSELLA, RC BUCKNER, SB BRATTHAUER, GL OCONNOR, DM OLEARY, TJ TI IDENTIFICATION OF GENITAL HERPES-SIMPLEX VIRUS-INFECTION BY IMMUNOPEROXIDASE STAINING - COMPARISON WITH CULTURE AND CYTOLOGY RESULTS SO APPLIED IMMUNOHISTOCHEMISTRY LA English DT Article DE HERPES VIRUS; CYTOLOGY ID POLYMERASE CHAIN-REACTION; DIRECT IMMUNOFLUORESCENCE; VIRAL-ISOLATION; DELIVERY; STRATEGIES; PREGNANCY; DIAGNOSIS; LESIONS; SAMPLES; ANTIGEN AB Although culture remains the ''gold standard'' for diagnosis of genital herpes simplex virus infections, it is both time consuming and expensive. We have investigated the diagnostic utility of an indirect immunoperoxidase staining method for diagnosis of herpes simplex virus in 392 women of childbearing age from whom both cervical cultures and Pap smears could be obtained. Herpes simplex virus was identified in the same seven patients by both culture and immunoperoxidase methods, indicating a high sensitivity and specificity of the immunoperoxidase method. These results suggest that the immunoperoxidase approach may be a rapid and inexpensive way to diagnose genital herpes simplex virus infection, and might be useful in the prevention of neonatal herpes virus infections. C1 ARMED FORCES INST PATHOL,DEPT CELLULAR PATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,DEPT OBSTET & GYNECOL,WASHINGTON,DC 20307. NR 20 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1062-3345 J9 APPL IMMUNOHISTOCHEM JI Appl. Immunohistochem. PD FAL PY 1995 VL 3 IS 3 BP 184 EP 189 PG 6 WC Anatomy & Morphology; Medical Laboratory Technology; Pathology SC Anatomy & Morphology; Medical Laboratory Technology; Pathology GA RT419 UT WOS:A1995RT41900006 ER PT J AU YIN, S LU, G ZHANG, J YU, FTS MAIT, JN AF YIN, S LU, G ZHANG, J YU, FTS MAIT, JN TI KINOFORM-BASED NIPKOW DISK FOR A CONFOCAL MICROSCOPE SO APPLIED OPTICS LA English DT Article AB A kinoform-based Nipkow-disk system, as applied to a real-time confocal microscope, is presented. The major advantage of this technique must be its high light efficiency (e.g., > 80%), which significantly improves the performance of a confocal microscope. Our preliminary experiment indicates that there are potential applications to three-dimensional microscopic imaging as well as to object surface detection. C1 USA,RES LAB,IA,SS,AMSRL,ADELPHI,MD 20783. RP YIN, S (reprint author), PENN STATE UNIV,DEPT ELECT ENGN,UNIVERSITY PK,PA 16802, USA. NR 6 TC 13 Z9 14 U1 3 U2 6 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD SEP 1 PY 1995 VL 34 IS 25 BP 5695 EP 5698 PG 4 WC Optics SC Optics GA RR044 UT WOS:A1995RR04400019 PM 21060399 ER PT J AU ROSEN, DL PENDLETON, JD AF ROSEN, DL PENDLETON, JD TI DETECTION OF BIOLOGICAL PARTICLES BY THE USE OF CIRCULAR-DICHROISM MEASUREMENTS IMPROVED BY SCATTERING-THEORY SO APPLIED OPTICS LA English DT Article DE CIRCULAR POLARIZATION; SCATTERING; OPTICAL ACTIVITY; CIRCULAR DICHROISM; BIODETECTION; MIE; APERTURE; CHIRAL ID LIGHT-SCATTERING; POLARIZATION; SPECTROSCOPY; ARTIFACTS AB Light scattered from optically active spheres was theoretically analyzed for biodetection. The circularly polarized signal of near-forward scattering from circularly dichroic spheres was calculated. Both remote and point biodetection were considered. The analysis included the effect of a circular aperture and beam block at the detector. If the incident light is linearly polarized, a false signal would limit the sensitivity of the biodetector. If the incident light is randomly polarized, shot noise would limit the sensitivity. Suggested improvements to current techniques include a beam block, precise angular measurements, randomly polarized light, index-matching fluid, and larger apertures for large particles. RP ROSEN, DL (reprint author), USA,RES LAB,BATTLEFIELD ENVIRONM DIRECTORATE,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 25 TC 3 Z9 3 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD SEP 1 PY 1995 VL 34 IS 25 BP 5875 EP 5884 PG 10 WC Optics SC Optics GA RR044 UT WOS:A1995RR04400043 PM 21060423 ER PT J AU SMITH, KJ SKELTON, HG YEAGER, J RUIZ, N WAGNER, KF AF SMITH, KJ SKELTON, HG YEAGER, J RUIZ, N WAGNER, KF TI METRONIDAZOLE FOR EOSINOPHILIC PUSTULAR FOLLICULITIS IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE 1-POSITIVE PATIENTS SO ARCHIVES OF DERMATOLOGY LA English DT Note ID INFECTION C1 USN,ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306. USN,BETHESDA,MD. RP SMITH, KJ (reprint author), USA,WASHINGTON,DC 20310, USA. NR 5 TC 18 Z9 19 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD SEP PY 1995 VL 131 IS 9 BP 1089 EP 1091 DI 10.1001/archderm.131.9.1089 PG 3 WC Dermatology SC Dermatology GA RU135 UT WOS:A1995RU13500024 PM 7661619 ER PT J AU HAMMILL, JP SEGAL, DR SEGAL, MD AF HAMMILL, JP SEGAL, DR SEGAL, MD TI SELF-SELECTION AND PARENTAL SOCIOECONOMIC-STATUS AS DETERMINANTS OF THE VALUES OF WEST-POINT CADETS SO ARMED FORCES & SOCIETY LA English DT Article; Proceedings Paper CT 88th Annual Meeting of the American-Sociological-Association CY AUG 13-17, 1993 CL MIAMI BEACH, FL SP Amer Sociol Assoc ID SOCIALIZATION AB This study examines the relationship between parental socioeconomic status (SES) and values in an entry-level class of cadets at the United States Military Academy in an exploration of the value bases of our future military elite. Following Kohn's model of social structure and values, we hypothesized relationships between parental SES and cadet orientations toward self-direction and conformity. We found little support for the model. Rather, there seems to be an overwhelming degree of value consensus among cadets, which we believe is a function of self-selection and anticipatory socialization. This is manifested in an expressed admiration for conformity and an expressed dislike for independent action. C1 UNIV MARYLAND,CTR INT & SECUR STUDIES,COLLEGE PK,MD 20742. UNIV MARYLAND,WOMENS STUDIES PROGRAM,COLLEGE PK,MD 20742. RP HAMMILL, JP (reprint author), US MIL ACAD,DEPT BS&L,W POINT,NY 10996, USA. NR 23 TC 18 Z9 18 U1 0 U2 0 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD FAL PY 1995 VL 22 IS 1 BP 103 EP & DI 10.1177/0095327X9502200106 PG 0 WC Political Science; Sociology SC Government & Law; Sociology GA TE839 UT WOS:A1995TE83900006 ER PT J AU LAKHANI, H AF LAKHANI, H TI REENLISTMENT INTENTIONS OF CITIZEN SOLDIERS IN THE US ARMY SO ARMED FORCES & SOCIETY LA English DT Article; Proceedings Paper CT 1993 Biennial Conference of the Inter-University-Seminar-on-Armed-Forces-and-Society CY OCT 22-24, 1993 CL BALTIMORE, MD SP Inter Univ Seminar Armed Forces & Soc AB This article analyzes the economic, attitudinal, institutional, and affective variables involved in predicting reenlistment intentions of citizen soldiers, i.e., Select Reserve and National Guard, in the U.S. Army. Data from the 1986 U.S. Department of Defense's Reserve Components Survey, matched with Reserve Components Common Personnel Data System files for 1985 to 1991, are analyzed to estimate the probability of reenlistment. The estimates reveal that reenlistment probability increases with an increase in reserve earnings, preferably as these match or surpass civilian wage opportunities. The attitudinal and affective variables, such as a spouse's favorable attitude toward the reservist's reenlistment, or a reservist's satisfaction with military life, or his/her job satisfaction, also increase reenlistment intentions. Reenlistment probability is, however, reduced if the reservist's primary job requires 45 or more hours per week, if a reservist's spouse is working for pay, or if a reservist spends a smaller percentage of time in the Primary Military Occupational Specialty (PMOS) for which he/she is trained. Policy implications of these results are discussed in the context of increasing reenlistment. RP LAKHANI, H (reprint author), USA,BEHAV & SOCIAL SCI RES INST,5001 EISENHOWER AVE,ALEXANDRIA,VA 22333, USA. NR 22 TC 8 Z9 8 U1 0 U2 3 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD FAL PY 1995 VL 22 IS 1 BP 117 EP & DI 10.1177/0095327X9502200107 PG 0 WC Political Science; Sociology SC Government & Law; Sociology GA TE839 UT WOS:A1995TE83900007 ER PT J AU ECHEVARRIA, AJ AF ECHEVARRIA, AJ TI CLAUSEWITZ IN ENGLISH - THE RECEPTION OF CLAUSEWITZ IN BRITAIN AND AMERICA, 1815-1945 - BASSFORD,C SO ARMED FORCES & SOCIETY LA English DT Book Review RP ECHEVARRIA, AJ (reprint author), US MIL ACAD,DEPT HIST,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD FAL PY 1995 VL 22 IS 1 BP 131 EP 133 DI 10.1177/0095327X9502200108 PG 3 WC Political Science; Sociology SC Government & Law; Sociology GA TE839 UT WOS:A1995TE83900008 ER PT J AU TOLNAY, M LAMBRIS, JD SMALLRIDGE, RC TSOKOS, GC AF TOLNAY, M LAMBRIS, JD SMALLRIDGE, RC TSOKOS, GC TI TRANSCRIPTIONAL CONTROL OF THE COMPLEMENT RECEPTOR-2 GENE BY AND INDUCIBLE NUCLEAR-PROTEIN THAT BINDS TO A CAMP REGULATORY ELEMENT-LIKE MOTIF IN THE PROMOTER REGION OF THE GENE SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20305. WALTER REED ARMY INST RES,DIV MED,WASHINGTON,DC 20307. UNIV PENN,DEPT PATHOL,PHILADELPHIA,PA 19104. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 1995 VL 38 IS 9 SU S BP 27 EP 27 PG 1 WC Rheumatology SC Rheumatology GA RX684 UT WOS:A1995RX68400027 ER PT J AU MURPHY, FT DENNIS, GJ AF MURPHY, FT DENNIS, GJ TI THE CLINICAL-SIGNIFICANCE OF REACTIVE FLUORESCENT TREPONEMAL ANTIBODY SEROLOGIES IN PATIENTS WITH SLE SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT RHEUMATOL & CLIN IMMUNOL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 1995 VL 38 IS 9 SU S BP 119 EP 119 PG 1 WC Rheumatology SC Rheumatology GA RX684 UT WOS:A1995RX68400119 ER PT J AU GRADY, EP CARPENTER, MT BATTAFARANO, DF OLDER, SA KOENIG, CD AF GRADY, EP CARPENTER, MT BATTAFARANO, DF OLDER, SA KOENIG, CD TI RHEUMATOLOGIC FINDINGS IN PERSIAN-GULF-WAR VETERANS SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,SAN ANTONIO,TX. NR 0 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 1995 VL 38 IS 9 SU S BP 1020 EP 1020 PG 1 WC Rheumatology SC Rheumatology GA RX684 UT WOS:A1995RX68401020 ER PT J AU TESAR, J KATONA, I HORNSTEIN, E SCHWARTZ, P AF TESAR, J KATONA, I HORNSTEIN, E SCHWARTZ, P TI PRIMARY ANTIPHOSPHOLIPID ANTIBODY SYNDROME (APAS) IN CHILDREN - B-2-GP-I DEPENDENCE OF APL ANTIBODY SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 1995 VL 38 IS 9 SU S BP 1111 EP 1111 PG 1 WC Rheumatology SC Rheumatology GA RX684 UT WOS:A1995RX68401110 ER PT J AU HOGAN, AW AF HOGAN, AW TI THE WEICKMANN,HELMUT MEMORIAL SO ATMOSPHERIC RESEARCH LA English DT Item About an Individual RP HOGAN, AW (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE PUBL CO INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0169-8095 J9 ATMOS RES JI Atmos. Res. PD SEP PY 1995 VL 38 IS 1-4 BP 1 EP 2 DI 10.1016/0169-8095(95)90023-3 PG 2 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA RX723 UT WOS:A1995RX72300001 ER PT J AU CALDWELL, JA LEWIS, JA AF CALDWELL, JA LEWIS, JA TI THE FEASIBILITY OF COLLECTING IN-FLIGHT EEG DATA FROM HELICOPTER PILOTS SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Note AB An assessment of whether valid EEG data could be collected on helicopter pilots in flight was conducted. Each subject provided eyes-open/eyes-closed EEG in the laboratory and in a helicopter. During flights, EEG's were monitored on the ground in real-time via radio telemetry. Analyses were conducted on the data recorded from Fz, Cz, Pz, P3, P4, O1, and O2 from eight subjects. Delta activity at one recording site (Fz) was higher in the aircraft than in the laboratory probably because of increased eye movements. Both theta and alpha activity at several sites also were increased in the aircraft, and alpha activity at all electrodes showed the expected augmentation from eyes-opened to eyes-closed; however, there were no interactions indicative of problems detecting normal alpha changes due to eye closure in the aircraft. Beta activity recorded from Cz and O1 was elevated during flight testing, but it was concluded that at least the O1 effect was due to muscle artifact in the more active environment. While there were more recording artifacts in the helicopter than in the laboratory, the overall results show it is possible to telemeter EEG from helicopter pilots in flight. Follow-on studies are needed to assess whether recordings can be obtained while pilots are performing flight-related tasks. RP CALDWELL, JA (reprint author), USA,AEROMED RES LAB,DIV AIRCREW HLTH & PERFORMANCE,POB 620577,FT RUCKER,AL 36360, USA. NR 9 TC 6 Z9 6 U1 1 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD SEP PY 1995 VL 66 IS 9 BP 883 EP 889 PN 1 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA RR602 UT WOS:A1995RR60200011 PM 7487829 ER PT J AU Rosen, LN AF Rosen, LN TI Life events and symptomatic recovery of Army spouses following Operation Desert Storm SO BEHAVIORAL MEDICINE LA English DT Article DE army wives; deployment; Operation Desert Storm; life events ID PSYCHIATRIC-ILLNESS; STRESS AB The relation between life events and psychiatric symptoms among wives of soldiers deployed to the Persian Gulf during Operation Desert Storm (ODS) was examined. Psychiatric symptoms were measured, using the 25-item Hopkins Symptom Checklist (HSCL), at two times, once while the soldiers were away and a second time several months after they returned In a multiple regression analysis, symptoms at Time 2 were predicted by post-Desert Storm events as well as by events and emotional stressors that occurred during the military operation. The strongest predictor of post-Desert Storm events was pre-Desert Storm events. The impact of the deployment was also assessed on the basis of respondents' symptom profiles over time. Although 70% of the respondents were symptomatic during the deployment, 40% had recovered by Time 2; only 24% were symptomatic at both times. Even in the latter group, there was an improvement in symptoms between Time 1 (T1) and Time 2 (T2). RP Rosen, LN (reprint author), WALTER REED ARMY MED CTR,DEPT MIL PSYCHIAT,SGRD UWI A,WASHINGTON,DC 20307, USA. NR 20 TC 3 Z9 3 U1 0 U2 1 PU HELDREF PUBLICATIONS PI WASHINGTON PA 1319 EIGHTEENTH ST NW, WASHINGTON, DC 20036-1802 SN 0896-4289 J9 BEHAV MED JI Behav. Med. PD FAL PY 1995 VL 21 IS 3 BP 131 EP 139 PG 9 WC Behavioral Sciences; Psychiatry SC Behavioral Sciences; Psychiatry GA TQ796 UT WOS:A1995TQ79600004 PM 8789649 ER PT J AU CARR, ME ALVING, BM AF CARR, ME ALVING, BM TI EFFECT OF FIBRIN STRUCTURE ON PLASMIN-MEDIATED DISSOLUTION OF PLASMA CLOTS SO BLOOD COAGULATION & FIBRINOLYSIS LA English DT Article DE PLASMINOGEN; UROKINASE; TISSUE PLASMINOGEN ACTIVATOR; DEXTRAN ID MASS-LENGTH RATIO; TISSUE ACTIVATOR; GELS; THROMBIN; FIBERS; DEGRADATION; TURBIDITY; FRAGMENTS; DENSITY; SIZE AB Previous studies in purified systems have demonstrated that fibrin structure influences the rate of conversion of plasminogen to plasmin by t-PA as well as the rate of plasmin-mediated clot digestion. The present study extended these observations to a plasma system in which fibrin structure was altered by varying the thrombin concentration, varying the plasma ionic strength, or by adding dextran 40. The effect of fibrin structure on the rate of fibrinolysis was assessed by adding plasminogen activators (t-PA or urokinase (UK)) either before or after clot formation, Gel formation and dissolution were monitored optically (turbidity) and isotopically (I-125-fibrinogen). Clots formed under conditions of high ionic strength and/or high thrombin concentration were composed of thin fibrin fibres that dissolved slowly. Clots formed at lower ionic strengths, at lower thrombin concentrations or in the presence of dextran were composed of thicker fibres and dissolved more rapidly. The difference in fibrinolytic rate between thin and thick fibres was noted when t-PA or UK was added before or after clot formation. These data indicate that even in a plasma milieu fibre diameter is a factor in determining fibrinolytic rate induced by either UK or t-PA. The method by which fibre diameter is altered does not influence the conclusion that fibrinolytic rate is increased with increasing diameter. C1 VIRGINIA COMMONWEALTH UNIV MED COLL VIRGINIA,DEPT PATHOL,DIV HEMATOL ONCOL,RICHMOND,VA 23298. MCGUIRE DEPT VET AFFAIRS MED CTR,RICHMOND,VA 23249. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT HEMATOL & VASC BIOL,WASHINGTON,DC 20307. RP CARR, ME (reprint author), VIRGINIA COMMONWEALTH UNIV MED COLL VIRGINIA,DEPT MED,DIV HEMATOL ONCOL,RICHMOND,VA 23298, USA. NR 39 TC 98 Z9 101 U1 1 U2 5 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0957-5235 J9 BLOOD COAGUL FIBRIN JI Blood Coagul. Fibrinolysis PD SEP PY 1995 VL 6 IS 6 BP 567 EP 573 DI 10.1097/00001721-199509000-00011 PG 7 WC Hematology SC Hematology GA RU630 UT WOS:A1995RU63000011 PM 7578900 ER PT J AU SUMFEST, JM AF SUMFEST, JM TI PSEUDOURETEROCELE - POTENTIAL FOR MISDIAGNOSIS OF AN ECTOPIC URETER AS A URETEROCELE - REPLY SO BRITISH JOURNAL OF UROLOGY LA English DT Letter RP SUMFEST, JM (reprint author), TRIPLER ARMY MED CTR,DIV PEDIAT UROL,HONOLULU,HI 96859, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0007-1331 J9 BRIT J UROL JI Br. J. Urol. PD SEP PY 1995 VL 76 IS 3 BP 412 EP 412 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA RT180 UT WOS:A1995RT18000040 ER PT J AU HONEYCUTT, ME MCFARLAND, VA MCCANT, DD AF HONEYCUTT, ME MCFARLAND, VA MCCANT, DD TI COMPARISON OF 3 LIPID EXTRACTION METHODS FOR FISH SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article ID POLYCHLORINATED-BIPHENYLS; BIOACCUMULATION; PCBS AB The role of lipids as the major compartment for neutral organic chemical partitioning in organism tissues has been well documented (Esser 1986; Roberts et al. 1977; Connell 1988; Schneider 1982). Lipid normalization is used in the calculation of accumulation factors (AF), which express the equilibrium distribution of neutral chemicals between sediments and aquatic biota (Ankley et al. 1992; Ferraro et al. 1990, 1991; Lake et al. 1990; McFarland et al. 1994; Young et al. 1991). A screening test used to estimate the bioaccumulation potential of neutral chemicals associated with dredged sediments relies on equilibrium partitioning to organism lipids (USEPA/USACE 1991). Additionally, the USEPA seeks to promulgate sediment quality criteria (SQC) that will require lipid normalization of data (USEPA 1993). Thus, lipid content of aquatic organism tissues is becoming an increasingly important parameter in environmental regulation involving contaminants in sediments. No standardized method exists for lipid determinations in environmental tissue samples. Typically, analysts either reserve an aliquot of a residue-analysis tissue extract for lipid analysis, or analyze a separate tissue sample for lipids concurrently. in the former case, hexane:acetone or dichloromethane are commonly used as solvents (Ryan et al. 1985; Schwartz et al. 1993). In the latter case, the chloroform:methanol (Bligh-Dyer) method is commonly used, as it is specifically intended for lipid analysis and is routinely used to measure the lipid content of foods (Bligh and Dyer 1959). Often, the amount of tissue used in either of the above cases may vary due to differing amounts of-tissue required (or available) for chemical analysis, or to the amount of sample remaining for lipid analysis after that required for chemical analysis has been taken. Knowledge of the variability that may be introduced due to sample size or solvent used is required in order to compare lipid-normalized data obtained from different studies. The purpose of this study was to assess these sources of variability by comparing percent lipid determinations made on different sample sizes of the same homogenized fish tissue. Three lipid extraction methods (Bligh-Dyer, hexane:acetone and dichloromethane) and six sample sizes representing a two hundred-fold range of tissue weights were compared. While other extraction methods, e.g., petroleum ether, pentane, acetonitrile, etc., are used to some extent, in our experience the three methods in the present study are the most often used, especially in the regulatory realm. C1 ASCI CORP,VICKSBURG,MS 39180. RP HONEYCUTT, ME (reprint author), USA,ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 19 TC 27 Z9 27 U1 0 U2 9 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0007-4861 J9 B ENVIRON CONTAM TOX JI Bull. Environ. Contam. Toxicol. PD SEP PY 1995 VL 55 IS 3 BP 469 EP 472 PG 4 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA RH075 UT WOS:A1995RH07500021 PM 8520156 ER PT J AU BERENBERG, JL TANGEN, C MACDONALD, JS HUTCHINS, LF NATALE, RB OISHI, N GUY, JT FLEMING, TR AF BERENBERG, JL TANGEN, C MACDONALD, JS HUTCHINS, LF NATALE, RB OISHI, N GUY, JT FLEMING, TR TI PHASE-II STUDY OF 5-FLUOROURACIL AND FOLINIC ACID IN THE TREATMENT OF PATIENTS WITH ADVANCED GASTRIC-CANCER - A SOUTHWEST-ONCOLOGY-GROUP STUDY SO CANCER LA English DT Article DE STOMACH NEOPLASMS; LEUCOVORIN; FLUOROURACIL; ANTINEOPLASTIC AGENTS ID BIOCHEMICAL MODULATION; ADENOCARCINOMAS; FLUOROURACIL; METHOTREXATE; DOXORUBICIN; LEUCOVORIN; CARCINOMA; TRIAL AB Background. The biochemical modulation of 5-fluorouracil (5-FU) by the reduced folate folinic acid (FA) in the treatment of patients with advanced gastric cancer was examined. Methods. The Southwest Oncology Group performed parallel randomized Phase II trials of two schedules of 5-FU and FA in 80 patients with advanced gastric cancer, Of 76 analyzable patients, 36 were randomized to receive bolus FA (200 mg/m(2), days 1-4) along with continuous infusion 5-FU (1000 mg/m(2), days 1-4) and 40 were randomized to receive bolus FA (200 mg/m(2), days 1-5) before the bolus 5-FU (375 mg/m(2), days 1-5). Results. There were three (8%) partial responses (95% confidence interval [CI] 2%-22%) on the continuous infusion arm. The bolus arm had two (5%) complete response rate of 20% (95% CI 9%-36%). The median duration of response was 4.6 months for the infusion patients and 16.6 months for the bolus patients. Survival was poor, with median survival of 5 months on both regimens. Gastrointestinal toxicity was substantial, with Grade 3 mucositis observed in 36% of patients on the continuous infusion regimen versus only 10% of patients on the bolus regimen. Grade 3 or higher hematologic toxicity occurred more often in the bolus arm than in the continuous infusion arm (28% vs. 14%, respectively). Two toxic deaths occurred, one related to sepsis the other secondary to coronary insufficiency. Conclusions. Biochemical modulation of 5-FU by FA using the dose and schedules tested has only modest activity in the treatment of advanced gastric cancer. C1 CTR CANC RES,HONOLULU,HI. TRIPLER ARMY MED CTR,HONOLULU,HI 96859. SW ONCOL GRP,CTR STAT,SEATTLE,WA. TEMPLE UNIV,PHILADELPHIA,PA 19122. UNIV ARKANSAS MED SCI HOSP,LITTLE ROCK,AR 72205. UNIV MICHIGAN,MED CTR,ANN ARBOR,MI 48109. COLUMBUS CCOP,COLUMBUS,OH. FU NCI NIH HHS [CA-32734, CA-37429, CA-37981] NR 21 TC 22 Z9 22 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD SEP 1 PY 1995 VL 76 IS 5 BP 715 EP 719 DI 10.1002/1097-0142(19950901)76:5<715::AID-CNCR2820760502>3.0.CO;2-3 PG 5 WC Oncology SC Oncology GA RP851 UT WOS:A1995RP85100001 PM 8625171 ER PT J AU MARSHALL, ME WOLF, M CRAWFORD, ED THOMPSON, IM FLANIGAN, R BALCERZAK, SP MEYERS, FJ AF MARSHALL, ME WOLF, M CRAWFORD, ED THOMPSON, IM FLANIGAN, R BALCERZAK, SP MEYERS, FJ TI EVALUATION OF LOW-DOSE ALPHA-INTERFERON (ROFERON-A(R)) IN PATIENTS WITH ADVANCED RENAL-CELL CARCINOMA - A SOUTHWEST-ONCOLOGY-GROUP STUDY SO CANCER BIOTHERAPY LA English DT Article DE RENAL CELL CARCINOMA; ALPHA-INTERFERON; ROFERON-A(R) ID DISSEMINATED MALIGNANT-MELANOMA; LEUKOCYTE-A INTERFERON; PHASE-II AB Alpha-interferon (IFN) has been shown to produce antitumor responses among patients with advanced venal cell carcinoma. While responses have been observed over a range of IFN doses and schedules, significant toxicities can be experienced from relatively high doses given three to five times weekly. Based upon the report of a pilot study indicating that low dose daily IFN could produce antitumor responses with minimal toxicity, the Southwest Oncology Group investigated this schema in a phase II trial. Patients with bidimensionally measurable disease were treated with Roferon-A(R) I million units subcutaneously daily and tumor assessments were conducted on a monthly basis. There were no dose escalations and no dose reductions for toxicity. The treatment was well tolerated with only two patients withdrawing from treatment because of side effects. Among 56 eligible patients treated, there were five partial responses and one complete response for an overall response rate of 11% (95% confidence interval 4 - 22%). However, objective antitumor responses could not be determined for 16 of the 56 patients. Among the 40 fully evaluable patients the 6 objective responses yields a response rate of 15% (95% confidence interval, 5.7 - 30%). It is concluded that this dose and schedule of IFN has activity against advanced renal cell carcinoma. A randomized trial would be required to determine if this low dose regimen is as effective as the higher doses which have been used traditionally. C1 UNIV CINCINNATI,MED CTR,CINCINNATI,OH 45267. UNIV COLORADO,DENVER,CO 80202. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. LOYOLA UNIV,CHICAGO,IL 60611. OHIO STATE UNIV,CTR HLTH,COLUMBUS,OH 43210. UNIV CALIF DAVIS,SACRAMENTO,CA 95817. RP MARSHALL, ME (reprint author), CTR STAT,SW ONCOL GRP,OPERAT OFF,SWOG-9012,14980 OMICRON DR,SAN ANTONIO,TX 78245, USA. FU NCI NIH HHS [CA-38926, CA-04920, CA-42777] NR 5 TC 12 Z9 12 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 1062-8401 J9 CANCER BIOTHERAPY JI Cancer Biother. PD FAL PY 1995 VL 10 IS 3 BP 205 EP 209 DI 10.1089/cbr.1995.10.205 PG 5 WC Oncology SC Oncology GA RU345 UT WOS:A1995RU34500004 PM 8547959 ER PT J AU FLEMING, RA CAPIZZI, RL ROSNER, GL OLIVER, LK SMITH, SJ SCHIFFER, CA SILVER, RT PETERSON, BA WEISS, RB OMURA, GA MAYER, RJ VANECHO, DA BLOOMFIELD, CD SCHILSKY, RL AF FLEMING, RA CAPIZZI, RL ROSNER, GL OLIVER, LK SMITH, SJ SCHIFFER, CA SILVER, RT PETERSON, BA WEISS, RB OMURA, GA MAYER, RJ VANECHO, DA BLOOMFIELD, CD SCHILSKY, RL TI CLINICAL-PHARMACOLOGY OF CYTARABINE IN PATIENTS WITH ACUTE MYELOID-LEUKEMIA - A CANCER AND LEUKEMIA GROUP-B STUDY SO CANCER CHEMOTHERAPY AND PHARMACOLOGY LA English DT Article DE CYTARABINE; LEUKEMIA ID HIGH-DOSE 1-BETA-D-ARABINOFURANOSYLCYTOSINE; CYTOSINE-ARABINOSIDE TRANSPORT; ARA-C; CELLS; METABOLISM; PHARMACOKINETICS; PHOSPHORYLATION; DEOXYCYTIDINE; ACCUMULATION; TOXICITY AB The pharmacokinetics of cytarabine (ara-C) were determined in 265 patients with acute myeloid leukemia (AML) receiving ara-C (200 mg/m(2) per day for 7 days as a continuous infusion) and daunorubicin during induction therapy. The mean (standard deviation) ara-C concentration at steady-state (Css) and systemic clearance (Cl) were 0.30 (0.13) mu M and 134(71) 1/h per m(2) respectively. Males had a significantly faster ara-C Cl (139 vs 131 1/h per m(2), P = 0.025) than females. Significant correlations were noted between ara-C Cl and the pretreatment, peripheral white blood cell count (P = 0.005) and pretreatment blast count (P = 0.020). No significant differences in ara-C Css or CI were noted in patients achieving complete remission compared with those failing therapy (P = 0.315, P = 0.344, respectively). No significant correlations were observed between ara-C pharmacokinetic parameters and several indices of patient toxicity. Our findings indicate that variability in ara-C disposition in plasma at this dosage level does not correlate with remission status or toxicity in patients with AML receiving initial induction therapy with ara-C and daunorubicin. C1 DUKE UNIV,MED CTR,DURHAM,NC. UPJOHN CO,KALAMAZOO,MI 49001. UNIV MARYLAND,CTR CANC,BALTIMORE,MD 21201. NEW YORK HOSP,NEW YORK,NY 10021. UNIV MINNESOTA,SCH MED,MINNEAPOLIS,MN 55455. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIV ALABAMA,BIRMINGHAM,AL. DANA FARBER CANC INST,BOSTON,MA 02115. ROSWELL PK CANC INST,BUFFALO,NY 14263. UNIV CHICAGO,CANC RES CTR,CHICAGO,IL 60637. RP FLEMING, RA (reprint author), WAKE FOREST UNIV,CTR COMPREHENS CANC,MED CTR BLVD,WINSTON SALEM,NC 27157, USA. FU NCI NIH HHS [CA-03927, CA-37027, CA-59518] NR 30 TC 13 Z9 14 U1 0 U2 1 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0344-5704 J9 CANCER CHEMOTH PHARM JI Cancer Chemother. Pharmacol. PD SEP PY 1995 VL 36 IS 5 BP 425 EP 430 DI 10.1007/BF00686192 PG 6 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA RN819 UT WOS:A1995RN81900010 PM 7634384 ER PT J AU PEOPLES, GE SMITH, RC LINEHAN, DC YOSHINO, I GOEDEGEBUURE, PS EBERLEIN, TJ AF PEOPLES, GE SMITH, RC LINEHAN, DC YOSHINO, I GOEDEGEBUURE, PS EBERLEIN, TJ TI SHARED T-CELL EPITOPES IN EPITHELIAL TUMORS SO CELLULAR IMMUNOLOGY LA English DT Article ID HUMAN-MELANOMA CELLS; OVARIAN-CANCER; INFILTRATING LYMPHOCYTES; PEPTIDES; RECOGNIZE; GENE; IDENTIFICATION; ANTIGENS; RECEPTOR; PROTEIN AB we have previously shown the importance of human leukocyte antigen (HLA)-A2 and the proto-oncogene HER2/neu in the T cell recognition of ovarian cancer, Since these proteins are ubiquitously expressed in epithelial-derived tumors, we have acid-eluted HLA-bound peptides from ovarian cancers, fractionated the peptides, and reconstituted T cell epitopes on the HLA-A2(+) T2 cell line to determine if common tumor-associated antigens exist among HLA-A2(+), HER2/neu(+) epithelial cancers. We demonstrate that tumor-specific cytotoxic T lymphocytes (CTL) generated from tumorinfiltrating lymphocytes isolated from three ovarian, two breast, and two non-small-cell lung cancers recognize at least three of the same peptide fractions from multiple elutions, One of these peptide fractions coelutes with a HERS/neu-derived peptide which has been shown recently to be recognized by these same CTL, These findings demonstrate that a common peptide-based tumor vaccine is theoretically possible for many different epithelial-derived cancers. (C) 1995 Academic Press, Inc. C1 HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,BIOL CANC THERAPY LAB,BOSTON,MA 02115. USA,DEPT MED,STUDENT DETACHMENT,FT SAM HOUSTON,TX 78234. HARVARD UNIV,CHILDRENS HOSP,SCH MED,DEPT SURG RES,BOSTON,MA 02115. FU NCI NIH HHS [CA09535, R01 CA45484] NR 25 TC 33 Z9 33 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 SN 0008-8749 J9 CELL IMMUNOL JI Cell. Immunol. PD SEP PY 1995 VL 164 IS 2 BP 279 EP 286 DI 10.1006/cimm.1995.1171 PG 8 WC Cell Biology; Immunology SC Cell Biology; Immunology GA RU196 UT WOS:A1995RU19600015 PM 7656335 ER PT J AU CARDELLO, AV AF CARDELLO, AV TI AGE, SENSORY FUNCTION, AND FOOD BEHAVIOR IN THE EXTENDED FAMILY SO CEREAL FOODS WORLD LA English DT Note ID RESPONSES; NEWBORNS RP CARDELLO, AV (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 14 TC 0 Z9 0 U1 1 U2 2 PU AMER ASSOC CEREAL CHEMISTS PI ST PAUL PA 3340 PILOT KNOB RD, ST PAUL, MN 55121-2097 SN 0146-6283 J9 CEREAL FOOD WORLD JI Cereal Foods World PD SEP PY 1995 VL 40 IS 9 BP 611 EP 613 PG 3 WC Food Science & Technology SC Food Science & Technology GA RR622 UT WOS:A1995RR62200008 ER PT J AU BRANNON, JM PENNINGTON, JC MCFARLAND, VA HAYES, C AF BRANNON, JM PENNINGTON, JC MCFARLAND, VA HAYES, C TI THE EFFECTS OF SEDIMENT CONTACT TIME ON K-OC OF NONPOLAR ORGANIC CONTAMINANTS SO CHEMOSPHERE LA English DT Article ID WATER PARTITION-COEFFICIENTS; POLYCHLORINATED BIPHENYL CONGENERS; HYDROPHOBIC POLLUTANTS; NATURAL SEDIMENTS; SORPTION; CHEMICALS; MATTER; SOILS; NONEQUILIBRIUM; HYDROCARBONS AB Mobility of nonpolar organic contaminants depends upon partitioning between sediment solids and interstitial water. The objective of this study was to measure the constancy of K-oc values for polychlorinated biphenyls (PCBs) and polynuclear aromatic hydrocarbons (PAHs) over time. Two PCBs and one PAH were incubated and sampled periodically over a 6 month period. Results demonstrated that as time of contact increased, the value of K-oc increased, reflecting a decrease in the truly dissolved contaminant concentration in the interstitial water. The data also showed a marked dependence of K-oc on the source of organic carbon and a 2 to 17 fold deviation of measured K-oc values from values predicted by empirical relationships. Therefore, empirical data may be the only truly reliable alternative for determining mobility potential of these contaminants. C1 ASCI CORP,MCLEAN,VA 22101. RP BRANNON, JM (reprint author), USA,ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39181, USA. NR 26 TC 12 Z9 12 U1 2 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD SEP PY 1995 VL 31 IS 6 BP 3465 EP 3473 DI 10.1016/0045-6535(95)00199-I PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA RX182 UT WOS:A1995RX18200011 ER PT J AU JONAS, WB AF JONAS, WB TI EFFECTIVENESS OF EDTA CHELATION-THERAPY SO CIRCULATION LA English DT Letter RP JONAS, WB (reprint author), WALTER REED ARMY INST RES,DIV MED,WASHINGTON,DC 20307, USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0009-7322 J9 CIRCULATION JI Circulation PD SEP 1 PY 1995 VL 92 IS 5 BP 1352 EP 1352 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA RR276 UT WOS:A1995RR27600046 PM 7648688 ER PT J AU KUSCHNER, RA TROFA, AF THOMAS, RJ HOGE, CW PITARANGSI, C AMATO, S OLAFSON, RP ECHEVERRIA, P SADOFF, JC TAYLOR, DN AF KUSCHNER, RA TROFA, AF THOMAS, RJ HOGE, CW PITARANGSI, C AMATO, S OLAFSON, RP ECHEVERRIA, P SADOFF, JC TAYLOR, DN TI USE OF AZITHROMYCIN FOR THE TREATMENT OF CAMPYLOBACTER ENTERITIS IN TRAVELERS TO THAILAND, AN AREA WHERE CIPROFLOXACIN RESISTANCE IS PREVALENT SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID ESCHERICHIA-COLI; INVITRO ACTIVITY; DOUBLE-BLIND; DIARRHEA; ERYTHROMYCIN; NORFLOXACIN; JEJUNI; PATHOGENS; CHILDREN; FLUOROQUINOLONES AB We evaluated the use of azithromycin (500 mg) or ciprofloxacin (500 mg) daily for 3 days for the treatment of acute diarrhea among United States military personnel in Thailand. Stool cultures were obtained and symptoms were recorded on study days 0, 1, 2, 3, and 10. Campylobacter species were the most common pathogen isolated (44 isolates from 42 patients). All Campylobacter isolates were susceptible to azithromycin; 22 were resistant to ciprofloxacin. Among the 42 patients with campylobacter infection, there were 2 clinical and 6 bacteriologic treatment failures in the ciprofloxacin group and no treatment failures in the azithromycin group (P = .021 for bacteriologic failures). Overall, azithromycin was as effective as ciprofloxacin in decreasing the duration of illness (36.9 hours vs. 38.2 hours, respectively) and the number of stools (6.4 vs. 7.8, respectively). Among those not infected with Campylobacter species (n = 30), the duration of illness was 32.9 hours vs, 20.7 hours (P = .03) for the azithromycin and ciprofloxacin groups, respectively. Azithromycin is superior to ciprofloxacin in decreasing the excretion of Campylobacter species and as effective as ciprofloxacin in shortening the duration of illness. Azithromycin therapy may be an effective alternative to ciprofloxacin therapy in areas where ciprofloxacin-resistant Campylobacter species are prevalent. C1 MARINE EXPEDIT FORCE 3,SURGEONS OFF,OKINAWA,JAPAN. ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. NAVAL MED RES UNIT 2,JAKARTA,INDONESIA. RP KUSCHNER, RA (reprint author), WALTER REED ARMY MED CTR,DEPT CLIN TRIALS,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307, USA. NR 38 TC 132 Z9 134 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD SEP PY 1995 VL 21 IS 3 BP 536 EP 541 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA RU940 UT WOS:A1995RU94000009 PM 8527539 ER PT J AU SHERMAN, RA WOERMAN, A KARSTETTER, KW MAY, H AF SHERMAN, RA WOERMAN, A KARSTETTER, KW MAY, H TI PREDICTION AND PORTRAYAL OF REPETITIVE STRESS-INDUCED LOWER-LIMB PAIN DISORDERS AMONG SOLDIERS IN BASIC TRAINING USING VIDEOTHERMOGRAPHY SO CLINICAL JOURNAL OF PAIN LA English DT Article DE THERMOGRAPHY; PAIN; LOWER LIMB; PREDICTION; DEPICTION ID SURFACE BLOOD-FLOW; THERMAL ASYMMETRY; QUANTIFICATION; THERMOGRAPHY; DIAGNOSIS AB Objective: Thermography has been widely espoused for both detecting and portraying pain problems. Development of repetitive stress-induced lower limb pain during army basic training is a relatively common occurrence. This study was designed to assess the usefulness of thermography for differentiating soldiers who developed lower limb pain during training from those who did not. This information was intended to be used to determine the usefulness of pretraining thermograms taken just as people came into the army in predicting which trainees would develop these conditions during training. Design: Videothermographic pictures were taken of the lower limbs of 639 newly enlisted soldiers who had just arrived at a large U.S. Army base but had not yet begun basic training, The amount of symmetry was correlated with the development of lower limb pain. Each soldier reporting lower limb pain and ''controls'' with nonpain problems (usually minor colds) received a thermographic evaluation identical to the original evaluation when they came for their medical examination. Results: Among prebasic trainees, 37% showed 1.0 degrees C of asymmetry somewhere in their lower limbs, 14% were asymmetrical by between 1, 1 degrees and 2.0 degrees C. 5% by 3.0 degrees C and 4% by 4.0 degrees C or more. Thus, only 40% of the prebasic trainees were within accepted ''normal'' limits before participating in training, Thirty-nine percent of those with asymmetrical thermograms developed lower limb pain compared with 28% of those with symmetrical thermograms (significant at p < 0.05). It was impossible to predict from any thermographic measurement on the lower limbs which soldiers were most likely to develop lower limb pain. This held true even for those pretrainees with the greatest asymmetries. Eighty-four percent of trainees reporting lower limb pain produced abnormal thermograms regardless of whether or not they produced abnormal thermograms prior to training. Conclusion: Thermograms were of little value for either predicting or portraying repetitive stress-induced lower limb pain in this population. C1 MADIGAN ARMY MED CTR,ORTHOPAED SURG SERV,FT LEWIS,WA. OLYMP SPORTS & SPINE REHABIL CLIN,PUYALLUP,WA. UNIV COLORADO,HLTH SCI CTR,DEPT ORTHOPED SURG,DENVER,CO. REYNOLDS ARMY COMMUNITY HOSP,PHYS THERAPY SERV,FT SILL,OK. NR 23 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0749-8047 J9 CLIN J PAIN JI Clin. J. Pain PD SEP PY 1995 VL 11 IS 3 BP 236 EP 241 PG 6 WC Anesthesiology; Clinical Neurology SC Anesthesiology; Neurosciences & Neurology GA TB564 UT WOS:A1995TB56400012 PM 8535044 ER PT J AU OKEEFE, RJ OCONNELL, JX TEMPLE, HT SCULLY, SP KATTAPURAM, SV SPRINGFIELD, DS ROSENBERG, AE MANKIN, HJ AF OKEEFE, RJ OCONNELL, JX TEMPLE, HT SCULLY, SP KATTAPURAM, SV SPRINGFIELD, DS ROSENBERG, AE MANKIN, HJ TI CALCIFIC MYONECROSIS - A LATE SEQUELA TO COMPARTMENT SYNDROME OF THE LEG SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID MYOSITIS-OSSIFICANS; FEATURES; SARCOMA AB The clinicopathologic features of calcific myonecrosis are presented from results of an examination of 3 cases of this rare syndrome and review of the literature, Calcific myonecrosis is a painful, expansile, calcified mass that develops in muscle several decades after lower extremity trauma that typically has been associated with vascular injury, Plain radiographs show a well-defined and heavily calcified mass replacing the leg musculature. The calcifications are present in a thin, linear pattern and are organized around the periphery of the lesion, Smooth erosion of the adjacent bone may be present, whereas magnetic resonance imaging shows a heterogeneous signal with enhancement limited to the periphery of the mass, Pathologic features consist of a centrally cystic mass arising in muscle filled with friable, tan to dark red, soft debris, The cyst walls are firm and fibrous and contain many needle-like, elongated, calcified shards of necrotic tissue composed of hypocellular fibrous tissue with focal aggregates of hemosiderin-laden macrophages. The cyst contents are composed of necrotic skeletal muscle and acellular amorphous debris containing many cholesterol crystals, fibrin, and recent hemorrhage, including focal aggregates of organizing thrombus, The pathologic findings suggest that calcific myonecrosis might expand with time by virtue of recurrent intralesional hemorrhage into a chronic calcified mass that eventually becomes symptomatic, Surgical intervention is associated with a high rate of complication, particularly in cases in which intralesional procedures have been done. C1 VANCOUVER GEN HOSP,DEPT PATHOL,VANCOUVER,BC V5Z 1M9,CANADA. WALTER REED ARMY MED CTR,DEPT ORTHOPAED,WASHINGTON,DC 20307. DUKE UNIV,MED CTR,DEPT ORTHOPAED,DURHAM,NC. MASSACHUSETTS GEN HOSP,DEPT RADIOL,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,ORTHOPAED SERV,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,DEPT PATHOL,BOSTON,MA 02114. RP OKEEFE, RJ (reprint author), UNIV ROCHESTER,MED CTR,DEPT ORTHOPAED,BOX 665,ROCHESTER,NY 14642, USA. NR 15 TC 27 Z9 29 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD SEP PY 1995 IS 318 BP 205 EP 213 PG 9 WC Orthopedics; Surgery SC Orthopedics; Surgery GA RV243 UT WOS:A1995RV24300027 PM 7671519 ER PT J AU HUGHES, SA AF HUGHES, SA TI NEARSHORE WAVEHEIGHT DURING STORMS - COMMENTS SO COASTAL ENGINEERING LA English DT Discussion ID WATER RP HUGHES, SA (reprint author), USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3839 J9 COAST ENG JI Coast. Eng. PD SEP PY 1995 VL 26 IS 1-2 BP 105 EP 107 DI 10.1016/0378-3839(95)00014-7 PG 3 WC Engineering, Civil; Engineering, Ocean SC Engineering GA TK305 UT WOS:A1995TK30500008 ER PT J AU SAETHER, E AF SAETHER, E TI CLOSED-FORM DERIVATION OF AN 8-NODE HEXAHEDRAL ELEMENT STIFFNESS MATRIX BY THE HYBRID STRESS METHOD SO COMMUNICATIONS IN NUMERICAL METHODS IN ENGINEERING LA English DT Article DE FINITE ELEMENT THEORY; EXPLICIT STIFFNESS MATRICES; HYBRID STRESS METHOD AB A general methodology for deriving explicit element stiffness matrices in hybrid stress formulations has recently been developed by the author. The technique utilizes special stress field transformations to eliminate the complementary energy matrix inherent to hybrid formulations, thus simplifying the stiffness definition such that an explicit evaluation can be accomplished. The elimination of numerical integration and matrix inversion results in a substantial decrease in computational cost. The methodology is applied to derive explicit algebraic expressions for the Pian-Tong hexahedral element stiffness matrix. RP SAETHER, E (reprint author), USA,RES LAB,MAT DIRECTORATE,AMSRL MA PA,COMPUTAT MECH GRP,WATERTOWN,MA 02172, USA. NR 4 TC 2 Z9 2 U1 0 U2 1 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 1069-8299 J9 COMMUN NUMER METH EN JI Commun. Numer. Methods Eng. PD SEP PY 1995 VL 11 IS 9 BP 775 EP 787 DI 10.1002/cnm.1640110908 PG 13 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA RV693 UT WOS:A1995RV69300007 ER PT J AU LOWREY, AH CRAMER, CJ URBAN, JJ FAMINI, GR AF LOWREY, AH CRAMER, CJ URBAN, JJ FAMINI, GR TI QUANTUM-CHEMICAL DESCRIPTORS FOR LINEAR SOLVATION ENERGY RELATIONSHIPS SO COMPUTERS & CHEMISTRY LA English DT Article; Proceedings Paper CT 3rd Conference on Computers in Chemistry, including the Workshop on Computational Methods for Large Molecular Systems CY JUN 23-26, 1994 CL WROCLAW, POLAND SP Polish Amer Sklodowska Curie Fdn ID WATER PARTITION-COEFFICIENTS; SOLVATOCHROMIC PARAMETERS; MOLECULAR-PROPERTIES; THEORETICAL DESCRIPTORS; PI-STAR; ALPHA; BETA; SOLUBILITY; SOLVENTS AB Linear solvation energy relationships (LSER) have been successfully used to correlate over 300 complex chemical and biochemical properties with small sets of descriptors related to fundamental characteristics of molecular structure and chemistry. This is a branch of the unnamed science (after Hansch) which is concerned with the intricate interactions between chemicals and life. Until recently, the descriptors in these relationships have been empirically determined. Recent developments in both the experimental understanding of these descriptors and in molecular orbital calculations have provided a new ground for fertile interaction between computational and experimental techniques. This manuscript describes development in the use of LSER and the recent molecular orbital formulations which provide basic descriptors developed from fundamental computational techniques. Examples from current research are presented to illustrate the expanding areas of chemistry accessible to these new ideas. C1 UNIV MINNESOTA,DEPT CHEM,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,INST SUPERCOMP,MINNEAPOLIS,MN 55455. USN ACAD,DEPT CHEM,ANNAPOLIS,MD 21402. USA,EDGEWOOD RES DEV & ENGN CTR,INT PROGRAMS OFF,ABERDEEN PROVING GROUND,MD 21010. RP LOWREY, AH (reprint author), USN,RES LAB,STRUCT MATTER LAB,WASHINGTON,DC 20375, USA. RI Cramer, Christopher/B-6179-2011 OI Cramer, Christopher/0000-0001-5048-1859 NR 52 TC 26 Z9 27 U1 1 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0097-8485 J9 COMPUT CHEM JI Comput. Chem. PD SEP PY 1995 VL 19 IS 3 BP 209 EP 215 DI 10.1016/0097-8485(94)00058-M PG 7 WC Chemistry, Multidisciplinary; Computer Science, Interdisciplinary Applications SC Chemistry; Computer Science GA RW142 UT WOS:A1995RW14200009 ER PT J AU ANDERSON, LL GIANDONI, MB KELLER, RA GRABSKI, WJ AF ANDERSON, LL GIANDONI, MB KELLER, RA GRABSKI, WJ TI SURGICAL-WOUND HEALING COMPLICATED BY ASPERGILLUS INFECTION IN A NONIMMUNOCOMPROMISED HOST SO DERMATOLOGIC SURGERY LA English DT Note ID INVASIVE EXTERNAL OTITIS AB BACKGROUND. An unusual complication of cutaneous surgery and its management is presented. Aspergillus flavus was identified from a nonhealing surgical wound of the ear undergoing cartilaginous necrosis in an immunocompetent host. OBJECTIVE. We wish to alert clinicians that Aspergillus may infect surgical wounds of the ear causing significant morbidity. METHOD. A healthy man underwent Mohs micrographic surgery for invasive Bowen's disease of the ear. Due to the size and location of the defect it was allowed to heal by secondary intent. The patient developed inflammation and subsequent destruction of the ear cartilage. Aspergillus was demonstrated by touch preps and cultured from swabs and tissue from the necrotic wound. RESULTS. In spite of aggressive topical and oral antifungal therapy severe distortion of the pinna occurred, resulting in surgical removal of the upper two-thirds of the ear. CONCLUSIONS. In the presence of cartilage necrosis following surgery on the ear, Aspergillus infection should be considered. Early aggressive management with surgical debridement, and topical and oral antifungal therapy may prevent destruction of the cartilage and a significant cosmetic defect. C1 BROOKE ARMY MED CTR,DERMATOL SERV,FT SAM HOUSTON,TX 78234. NR 9 TC 11 Z9 13 U1 1 U2 1 PU ELSEVIER SCIENCE PUBL CO INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 1076-0512 J9 DERMATOL SURG JI Dermatol. Surg. PD SEP PY 1995 VL 21 IS 9 BP 799 EP 801 PG 3 WC Dermatology; Surgery SC Dermatology; Surgery GA RT680 UT WOS:A1995RT68000011 PM 7655801 ER PT J AU SWAB, JJ SWEENEY, MP AF SWAB, JJ SWEENEY, MP TI FRACTURE-ANALYSIS OF AN ALL-CERAMIC BEARING SYSTEM SO ENGINEERING FAILURE ANALYSIS LA English DT Article ID SILICON-NITRIDE; STRESS RUPTURE; SI3N4 AB This paper summarizes the fracture mechanism of an all-ceramic duplex spin bearing which was tested to failure to establish a design load margin. This bearing is part of a gyro-optics assembly being developed for use in an infrared seeker. The analysis revealed that machining-induced microcracks grew in the inner raceway beneath a ball. These microcracks coalesced to form macrocracks which led to fracture of the inner race and the failure of the bearing system. C1 RAYTHEON CO,DIV MISSILE SYST,TEWKSBURY,MA 01876. RP SWAB, JJ (reprint author), USA,RES LAB,CERAM RES BRANCH,MAT DIRECTORATE,405 ARSENAL ST,WATERTOWN,MA 01272, USA. NR 20 TC 3 Z9 3 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 1350-6307 J9 ENG FAIL ANAL JI Eng. Fail. Anal. PD SEP PY 1995 VL 2 IS 3 BP 175 EP 190 DI 10.1016/1350-6307(95)00018-L PG 16 WC Engineering, Mechanical; Materials Science, Characterization & Testing SC Engineering; Materials Science GA TE120 UT WOS:A1995TE12000002 ER PT J AU HILL, CA DUBLYANSKY, YV HARMON, RS SCHLUTER, CM AF HILL, CA DUBLYANSKY, YV HARMON, RS SCHLUTER, CM TI OVERVIEW OF CALCITE/OPAL DEPOSITS AT OR NEAR THE PROPOSED HIGH-LEVEL NUCLEAR WASTE SITE, YUCCA MOUNTAIN, NEVADA, USA - PEDOGENIC, HYPOGENE, OR BOTH SO ENVIRONMENTAL GEOLOGY LA English DT Review DE YUCCA MOUNTAIN; CALCITE OPAL DEPOSITS; HYPOGENE; PEDOGENIC ID GREAT-BASIN; ROCKS; CALIFORNIA; CARBONATES; AREA AB Calcite/opal deposits (GOD) at Yucca Mountain were studied with respect to their regional and field geology, petrology and petrography, chemistry and isotopic geochemistry, and fluid inclusions. They were also compared with true pedogenic deposits (TPD), groundwater spring deposits (GSD), and calcite vein deposits (CVD) in the subsurface. Some of the data are equivocal and can support either a hypogene or pedogenic origin for these deposits. However, Sr-, C-, and O-isotope, fluid inclusion, and other data favor a hypogene interpretation. A hypothesis that may account for all currently available data is that the COD precipitated from warm, CO2-rich water that episodically upwelled along faults during the Pleistocene, and which, upon reaching the surface, flowed downslope within existing alluvial, colluvial, eluvial, or soil deposits. Being formed near, or on, the topographic surface, the COD acquired characteristics of pedogenic deposits. This subject relates to the suitability of Yucca Mountain as a high-level nuclear waste site. C1 RUSSIAN ACAD SCI,INST MINERAL & PETROG,NOVOSIBIRSK 630090,RUSSIA. USA,RES OFF,TERR SCI PROGRAM,RES TRIANGLE PK,NC 27709. TECHNOL & RESOURCE ASSESSMENT CORP,BOULDER,CO 80303. NR 65 TC 16 Z9 17 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0177-5146 J9 ENVIRON GEOL JI Environ. Geol. PD SEP PY 1995 VL 26 IS 2 BP 69 EP 88 PG 20 WC Environmental Sciences; Geosciences, Multidisciplinary; Water Resources SC Environmental Sciences & Ecology; Geology; Water Resources GA RW164 UT WOS:A1995RW16400001 ER PT J AU LI, J WIRTZ, RA MCCONKEY, GA SATTABONGKOT, J WATERS, AP ROGERS, MJ MCCUTCHAN, TF AF LI, J WIRTZ, RA MCCONKEY, GA SATTABONGKOT, J WATERS, AP ROGERS, MJ MCCUTCHAN, TF TI PLASMODIUM - GENUS-CONSERVED PRIMERS FOR SPECIES IDENTIFICATION AND QUANTITATION SO EXPERIMENTAL PARASITOLOGY LA English DT Article DE MALARIA; PLASMODIUM FALCIPARUM; PLASMODIUM GALLINACEUM; PLASMODIUM KNOWLESI; PLASMODIUM MALARIAE; PLASMODIUM OVALE; PLASMODIUM VIVAX; SSU RIBOSOMAL-RNA; 18S RIBOSOMAL-RNA; COMPETITIVE RT/PCR; DIAGNOSTICS ID SUBUNIT RNA SEQUENCES; RIBOSOMAL-RNA; FALCIPARUM; MALARIA; GENES; COMPILATION; DIAGNOSIS; BERGHEI AB Stable RNAs have regions of primary sequence that are nearly identical in every member of the Plasmodium genus and not found in the host or in other common pathogens. Several ''genus-conserved'' sequences, which flank hypervariable regions, were identified within the small subunit ribosomal RNA of Plasmodium species. Primers based on these conserved sequences permit amplification of species- or possibly even strain-specific sequences from samples of unknown composition. As an example of this approach, sequences from the four human malaria species were successfully recovered from Giemsa-stained blood smears, including two different sequences for Plasmodium ovale (of 91.5% similarity). This type of information is useful for epidemiological and phylogenetic analysis of any malaria species. We show that amplification of rRNA-derived sequences behaves in a competitive fashion during the cycles of polymerase amplification and therefore target sequences from Plasmodium species are amplified in proportion to their abundance in the sample. There are several implications of this finding. (1) The proportion of different products resulting from amplification from samples with mixed infections is closely related to the proportion of infecting species, (2) Direct quantitation of parasite nucleic acids within a sample can be derived when known amounts of competitor RNA are added to the RT/PCR reaction. (3) Amplification of rRNA sequences, using genus-specific primers, allows one to monitor the development of the parasite in the mosquito. (C) 1995 Academic Press, Inc. C1 WALTER REED ARMY MED CTR,DEPT ENTOMOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. NIAID,PARASIT DIS LAB,GROWTH & DEV SECT,BETHESDA,MD 20892. LEIDEN UNIV,PARASITOL LAB,LEIDEN,NETHERLANDS. USA,MED COMPONENT,DEPT ENTOMOL,BANGKOK,THAILAND. RP LI, J (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT PREVENT MED & BIOMETR,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. RI Waters, Andy/C-9377-2009 OI Waters, Andy/0000-0001-8900-2982 NR 21 TC 77 Z9 82 U1 1 U2 4 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 SN 0014-4894 J9 EXP PARASITOL JI Exp. Parasitol. PD SEP PY 1995 VL 81 IS 2 BP 182 EP 190 DI 10.1006/expr.1995.1107 PG 9 WC Parasitology SC Parasitology GA RV904 UT WOS:A1995RV90400005 PM 7556560 ER PT J AU BENSEN, CH CHAMBERLAIN, EJ ERICKSON, AE WANG, XD AF BENSEN, CH CHAMBERLAIN, EJ ERICKSON, AE WANG, XD TI ASSESSING FROST DAMAGE IN COMPACTED CLAY LINERS SO GEOTECHNICAL TESTING JOURNAL LA English DT Article DE FROST; FREEZE-THAW; CLAY LINER; HYDRAULIC CONDUCTIVITY; FIELD TESTS ID HYDRAULIC CONDUCTIVITY; FREEZE-THAW AB Methods used to assess frost damage (here defined as a large increase in hydraulic conductivity) in compacted clay liners are reviewed and evaluated using data collected from two test pads that were instrumented and then exposed to winter weather. The methods include comparisons of measurements of either water content and dry unit weight or hydraulic conductivity made before and after winter exposure. Field and laboratory methods of assessing hydraulic conductivity are considered. The comparison shows that assessments based on water content and dry unit weight can be misleading. Assessments based on hydraulic conductivity are recommended. Field hydraulic conductivity tests can be useful provided the soil is not disturbed or smeared and the test method permits evaluation of liners partially penetrated by frost. In this study however, the field tests yielded only qualitative results. Laboratory tests can also be used provided undisturbed specimens of sufficient size are collected. Specimens 70 mm in diameter were of adequate size in this study. Suitable specimens can be collected as blocks from thawed soil or with a core barrel while the soil is frozen. Collecting specimens in thin-wall sampling tubes (i.e., ''Shelby'' tubes) causes significant disturbance of thawed soil and thus is not recommended. Data are also presented to illustrate that laboratory tests should be conducted at effective stresses similar to those existing in the field. C1 USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. CH2M HILL INC,MILWAUKEE,WI 53202. RP BENSEN, CH (reprint author), UNIV WISCONSIN,DEPT CIVIL & ENVIRONM ENGN,GEOTECH LAB,MADISON,WI 53706, USA. NR 27 TC 10 Z9 10 U1 0 U2 0 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0149-6115 J9 GEOTECH TEST J JI Geotech. Test. J. PD SEP PY 1995 VL 18 IS 3 BP 324 EP 333 PG 10 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA RW291 UT WOS:A1995RW29100003 ER PT J AU TAYLOR, RR LINNOILA, RI GERARDTS, J TENERIELLO, MG NASH, JD PARK, RC BIRRER, MJ AF TAYLOR, RR LINNOILA, RI GERARDTS, J TENERIELLO, MG NASH, JD PARK, RC BIRRER, MJ TI ABNORMAL EXPRESSION OF THE RETINOBLASTOMA GENE IN OVARIAN NEOPLASMS AND CORRELATION TO P53 AND K-RAS MUTATIONS SO GYNECOLOGIC ONCOLOGY LA English DT Article ID CANCER; OVEREXPRESSION AB We analyzed the expression of the retinoblastoma (Rb) gene in a group of ovarian neoplasms previously characterized for mutations in the p53 suppressor gene and the Ki-ras oncogene, Using immunohistochemical techniques, a total of 59 ovarian neoplasms spanning the histiologic spectrum from benign to malignant were examined for the expression of the Rb protein. All benign cystic adenomas and low malignant potential tumors exhibited normal expression of the Rb protein, Abnormalities in Rb protein staining were noted in 3 of 22 (14%) ovarian carcinomas. The staining patterns included tumors that were totally or focally negative for Rb protein. One tumor focally expressed Rb. This tumor demonstrated a direct juxtaposition of sections of Rb expressing and nonexpressing malignant epithelial cells. Two of the three tumors with abnormal Rb expression also had p53 mutations and staining on serial sections demonstrated that selected ovarian cancer cells possessed mutations in both oncogenes. These data suggest that the loss of Rb gene expression may play a role in the pathogenesis of a small number of invasive ovarian malignancies, but not in noninvasive ovarian neoplasms. C1 NCI, EDCOP, BRPB, DIV CANC PREVENT & CONTROL, ROCKVILLE, MD 20850 USA. NATL NAVAL MED CTR, DEPT OBSTET & GYNECOL GYNECOL ONCOL, BETHESDA, MD 20889 USA. WALTER REED ARMY MED CTR, DEPT OBSTET & GYNECOL GYNECOL ONCOL, WASHINGTON, DC 20307 USA. UNIV N CAROLINA, DEPT SURG PATHOL, CHAPEL HILL, NC 27514 USA. NR 15 TC 19 Z9 19 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD SEP PY 1995 VL 58 IS 3 BP 307 EP 311 DI 10.1006/gyno.1995.1235 PG 5 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA RU141 UT WOS:A1995RU14100005 PM 7545631 ER PT J AU BREDOW, JW PORCO, RL FUNG, AK TJUATJA, S JEZEK, KC GOGINENI, S GOW, AJ AF BREDOW, JW PORCO, RL FUNG, AK TJUATJA, S JEZEK, KC GOGINENI, S GOW, AJ TI DETERMINATION OF VOLUME AND SURFACE SCATTERING FROM SALINE ICE USING ICE SHEETS WITH PRECISELY CONTROLLED ROUGHNESS PARAMETERS SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article; Proceedings Paper CT 14th Annual International Geoscience and Remote Sensing Symposium (IGARSS 94) CY AUG 08-12, 1994 CL CALIF INST TECHNOL, PASADENA, CA SP IEEE, Geosci & Remote Sensing Soc, Int Union Radio Sci, Opt Soc Amer HO CALIF INST TECHNOL AB Experiments were performed at the U.S. Army Cold Regions Research and Engineering Laboratory (CRREL) in Hanover, NH, to precisely determine the relative contributions of surface and volume scattering from saline ice that has well-known surface roughness characteristics. The ice growth phase of the experiment made use of two 6-ft diameter tanks and a 6-ft diameter mold with known roughness statistical parameters of rms height = 0.25 cm and Gaussian correlation (correlation length = 2.0 cm). One tank was used for growing a moderately thick saline ice sheet with very smooth surface, and the other was used for growing a thin layer of freshwater ice over the surface mold. The latter resulted in a layer with one statistically known rough boundary and one smooth boundary. Wide-bandwidth, multiple incidence angle backscattering measurements were performed, first on the bare saline ice sheet and then on the same sheet after the thin freshwater ice sheet was placed on top of it. Results indicate that the surface scattering dominates over saline ice volume scattering at all frequencies for low incidence angles for both the very smooth and Gaussian rough surfaces. The significance of volume scattering depends strongly on angle of incidence, frequency, volume scattering albedo, surface roughness, and surface correlation function. C1 OHIO STATE UNIV,BYRD POLAR RES CTR,COLUMBUS,OH 43210. USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. UNIV KANSAS,DEPT ELECT ENGN & COMP SCI,RADAR SYST & REMOTE SENSING LAB,LAWRENCE,KS 66045. RP BREDOW, JW (reprint author), UNIV TEXAS,WAVE SCATTERING RES CTR,DEPT ELECT ENGN,ARLINGTON,TX 76019, USA. NR 5 TC 1 Z9 1 U1 1 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD SEP PY 1995 VL 33 IS 5 BP 1214 EP 1221 DI 10.1109/36.469485 PG 8 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA TB578 UT WOS:A1995TB57800014 ER PT J AU SADDOW, SE LEE, CH AF SADDOW, SE LEE, CH TI OPTICAL CONTROL OF MICROWAVE-INTEGRATED CIRCUITS USING HIGH-SPEED GAAS AND SI PHOTOCONDUCTIVE SWITCHES SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article ID SEMICONDUCTOR AB An optoelectronic attenuator suitable for the optical control of microwave-integrated circuits is presented. High-speed photoconductive switches are embedded in planar microwave transmission lines fabricated on both semi-insulating GaAs and high-resistivity silicon substrates, and a fiber pigtailed semiconductor laser diode is used to control the microwave signal level on these high-speed lines. Forty-five dB of microwave attenuation was demonstrated with a silicon coplanar waveguide-photoconductive switch, while up to 8.5 dB of attenuation was achieved with a GaAs device. In addition, the optically induced phase delay through the silicon device was observed to be as large as 180 degrees. The microwave performance of these photoconductive devices has been fully characterized and their, suitability for various optical control applications compared. So that one can optimize the laser diode/GaAs photoconductive device interaction, the GaAs device has been characterized as a function of laser photon energy, switch temperature, and applied de electric field, and the optimum operating point has been determined through experiment. C1 UNIV MARYLAND,DEPT ELECT ENGN,COLLEGE PK,MD 20742. RP SADDOW, SE (reprint author), USA,RES LAB,ADELPHI,MD 20783, USA. NR 19 TC 12 Z9 13 U1 1 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD SEP PY 1995 VL 43 IS 9 BP 2414 EP 2420 DI 10.1109/22.414597 PN 2 PG 7 WC Engineering, Electrical & Electronic SC Engineering GA RU479 UT WOS:A1995RU47900036 ER PT J AU BALLATO, A AF BALLATO, A TI PIEZOELECTRICITY - OLD EFFECT, NEW THRUSTS SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article ID ELASTIC-CONSTANTS; BIMORPHS AB A tutorial synopsis of the piezoelectric effect is presented in the context of its history, traditional uses, and relation to crystal symmetry. Associated effects are briefly noted. Future prospects, particularly in the area of microelectromechanical systems/structures (MEMS) are discussed. RP BALLATO, A (reprint author), USA,RES LAB,AMSRL PS,PHYS SCI DIRECTORATE,FT MONMOUTH,NJ 07703, USA. NR 68 TC 54 Z9 55 U1 3 U2 8 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD SEP PY 1995 VL 42 IS 5 BP 916 EP 926 DI 10.1109/58.464826 PG 11 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA RW007 UT WOS:A1995RW00700016 ER PT J AU DRAZEK, ES HOUNG, HSH CRAWFORD, RM HADFIELD, TL HOOVER, DL WARREN, RL AF DRAZEK, ES HOUNG, HSH CRAWFORD, RM HADFIELD, TL HOOVER, DL WARREN, RL TI DELETION OF PURE ATTENUATES BRUCELLA-MELITENSIS 16M FOR GROWTH IN HUMAN MONOCYTE-DERIVED MACROPHAGES SO INFECTION AND IMMUNITY LA English DT Article ID POLYMORPHONUCLEAR LEUKOCYTES; SALMONELLA-TYPHIMURIUM; AUXOTROPHIC MUTANTS; ABORTUS; VIRULENCE; STRAINS; INHIBITION; MICE AB We constructed a defined purine-auxotrophic mutant of Brucella melitensis 16M by chromosomal gene replacement, We electroporated B, melitensis 16M with suicide plasmids containing a kanamycin resistance cassette that replaced 226 bp at the carboxyl end of purE, the intergenic region, and 18 bases of the purK open reading frame, Recombinant B, melitensis Delta purE201 required exogenous purines for growth on minimal media. Purine auxotrophy was complemented by electroporation of B, melitensis Delta purE201 with a plasmid, pSD5, carrying only the wild-type purE gene, In in vitro assays of virulence, B, melitensis Delta purE201 failed to grow in human monocyte-derived macrophages, while the growth of wild-type 16M and the complemented strain, Delta purE201(pSD5), increased by nearly two logs, These results suggest that B, melitensis Delta purE201 will be attenuated in animals and humans and thus may be useful as a live attenuated vaccine. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTER INFECT,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,DEPT INFECT & PARASIT DIS,WASHINGTON,DC 20306. RP DRAZEK, ES (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,BLDG 40,RM 1021,WASHINGTON,DC 20307, USA. NR 31 TC 40 Z9 42 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD SEP PY 1995 VL 63 IS 9 BP 3297 EP 3301 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA RQ792 UT WOS:A1995RQ79200009 PM 7642258 ER PT J AU ENGLISH, JC COLLINS, M BRYANTBRUCE, C AF ENGLISH, JC COLLINS, M BRYANTBRUCE, C TI PITYRIASIS LICHENOIDES ET VARIOLIFORMIS ACUTA AND GROUP-A BETA-HEMOLYTIC STREPTOCOCCAL INFECTION SO INTERNATIONAL JOURNAL OF DERMATOLOGY LA English DT Note ID MUCHA-HABERMANNS DISEASE; ASSOCIATION C1 USA,MED DEPT ACTIV,DEPT PRIMARY CARE & COMMUNITY MED,FT CAMPBELL,KY 42223. USA,MED DEPT ACTIV,DEPT MED DERMATOL,FT CAMPBELL,KY 42223. NR 10 TC 11 Z9 13 U1 0 U2 0 PU DECKER PERIODICALS INC PI HAMILTON PA 4 HUGHSON ST, PO BOX 620, LCD 1, HAMILTON ON L8N 3K7, CANADA SN 0011-9059 J9 INT J DERMATOL JI Int. J. Dermatol. PD SEP PY 1995 VL 34 IS 9 BP 642 EP 644 DI 10.1111/j.1365-4362.1995.tb01097.x PG 3 WC Dermatology SC Dermatology GA RT768 UT WOS:A1995RT76800014 PM 7591466 ER PT J AU WRIGHT, TW AF WRIGHT, TW TI SCALING LAWS FOR ADIABATIC SHEAR BANDS SO INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES LA English DT Article; Proceedings Paper CT International Symposium on Dynamic Failure Mechanics of Modern Materials CY 1994 CL CALIF INST TECHNOL, PASADENA, CA HO CALIF INST TECHNOL AB Mathematical analysis of a simple, one-dimensional, canonical problem has yielded a number of scaling laws that relate various characteristic features of an adiabatic shear band to the physical properties of the material and the ambient conditions. Specific formulas have been obtained from solutions to linear and non-linear problems coupled with asymptotic representations of the results. Examples are shear band width, most sensitive strain rate and shear band spacing. Other results show the equivalence of initial fluctuations in strength or temperature, and still others show how to scale the defect in formulas for estimating the timing of localization. The paper summarizes previous results and presents some new formulas that show how strain rate sensitivity affects band spacing, number density acid morphology as a function of strain rate. RP WRIGHT, TW (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 9 TC 10 Z9 10 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0020-7683 J9 INT J SOLIDS STRUCT JI Int. J. Solids Struct. PD SEP PY 1995 VL 32 IS 17-18 BP 2745 EP 2750 DI 10.1016/0020-7683(94)00289-9 PG 6 WC Mechanics SC Mechanics GA RL557 UT WOS:A1995RL55700020 ER PT J AU PLUMMER, JD EDZWALD, JK KELLEY, MB AF PLUMMER, JD EDZWALD, JK KELLEY, MB TI REMOVING CRYPTOSPORIDIUM BY DISSOLVED-AIR FLOTATION SO JOURNAL AMERICAN WATER WORKS ASSOCIATION LA English DT Article ID WATER-SUPPLIES; GIARDIA; OUTBREAK AB Bench-scale studies were used to investigate the effectiveness of dissolved-air flotation (DAF) for the removal of Cryptosporidium parvum oocysts from a drinking water supply. Oocysts were spiked into a natural water at a concentration of 3-4 x 10(5) oocysts/L. Results indicate that DAF achieved a > 2-log removal of oocysts under a variety of conditions. In addition, flotation was a superior clarification process to sedimentation for the conditions tested. Coagulation and DAF conditions that minimize residual turbidity and maximize the removals of organic matter are conditions that produce high log removals of Cryptosporidium. C1 US MIL ACAD,DEPT GEOG & ENVIRONM ENGN,W POINT,NY 10996. RP PLUMMER, JD (reprint author), UNIV MASSACHUSETTS,DEPT CIVIL & ENVIRONM ENGN,235 MARSTON HALL,AMHERST,MA 01003, USA. NR 25 TC 31 Z9 32 U1 1 U2 4 PU AMER WATER WORKS ASSN PI DENVER PA 6666 W QUINCY AVE, DENVER, CO 80235 SN 0003-150X J9 J AM WATER WORKS ASS JI J. Am. Water Work Assoc. PD SEP PY 1995 VL 87 IS 9 BP 85 EP 95 PG 11 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA RU888 UT WOS:A1995RU88800011 ER PT J AU LOOMIS, LD DEAL, CD KERSEY, KS BURKE, DS REDFIELD, RR BIRX, DL AF LOOMIS, LD DEAL, CD KERSEY, KS BURKE, DS REDFIELD, RR BIRX, DL TI HUMORAL RESPONSES TO LINEAR EPITOPES ON THE HIV-1 ENVELOPE IN SEROPOSITIVE VOLUNTEERS AFTER VACCINE THERAPY WITH RGP160 SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE HUMAN IMMUNODEFICIENCY VIRUS; ENVELOPE GLYCOPROTEIN; VACCINE THERAPY; EPITOPE MAPPING; PEPSCAN; IMMUNOBLOTTING ID HUMAN-IMMUNODEFICIENCY-VIRUS; B-CELL EPITOPES; RECOMBINANT GP160; SYNTHETIC PEPTIDES; AMINO-ACID; NEUTRALIZING ANTIBODIES; IMMUNE-RESPONSE; SERONEGATIVE VOLUNTEERS; MONOCLONAL-ANTIBODIES; INFECTIOUS-DISEASES AB Humoral responses to the HIV-1 envelope were investigated in 30 human volunteers enrolled in a phase I vaccine therapy trial of rgp160 (LAI/LAV) using two techniques that emphasize detection of antibody response against linear (continuous) epitopes: immunoblotting and PEPSCAN. Seven fusion proteins containing large portions from constant regions 1, 2, 3, and 5, and variable region 3 of gp120 and two regions in the transmembrane protein, gp41, were employed in immunoblots to quantitatively measure immune response as a function of immunization. In addition, the entire gp160 (LAI/LAV) envelope protein was constructed in duplicate sets of 211 overlapping 12-mer peptides to fine-map the changes. Immunoblotting defined significant changes in reactivity to epitopes in constant regions; of 28 volunteers completing the trial, the percentage with reactivity against C1 changed from 62 to 100%; for C2, from 0 to 46%; for C3, from 0 to 82%; and for a constant region in gp41, from 25 to 68%. PEPSCAN on a subset (n = 8) of these volunteers identified new reactivity to epitopes throughout the envelope, concentrated in V1, C3, and C5 in gp120 and several peptides in gp41. Completely immunized patients responded to double the number of linear epitopes compared with two patients receiving alum alone. The results verify that the response to rgpl60 is significantly broadened after immunization, providing additional evidence that HIV-1-infected volunteers can expand their antibody repertoire against a protein from a pathogen during chronic infection with that same pathogen. These results expand those previously obtained in this patient cohort, by defining explicitly the immunogenic regions recognized postvaccination and by providing methodology for quantitating those changes. C1 WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,ROCKVILLE,MD. WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD. RP LOOMIS, LD (reprint author), HENRY M JACKSON FDN,HIV LAB,13 TAFT COURT,SUITE 200,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 NR 85 TC 19 Z9 20 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD SEP 1 PY 1995 VL 10 IS 1 BP 13 EP 26 PG 14 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA RR296 UT WOS:A1995RR29600003 PM 7544225 ER PT J AU LILENBAUM, RC RATAIN, MJ MILLER, AA HARGIS, JB HOLLIS, DR ROSNER, GL OBRIEN, SM BREWSTER, L GREEN, MR SCHILSKY, RL AF LILENBAUM, RC RATAIN, MJ MILLER, AA HARGIS, JB HOLLIS, DR ROSNER, GL OBRIEN, SM BREWSTER, L GREEN, MR SCHILSKY, RL TI PHASE-I STUDY OF PACLITAXEL AND TOPOTECAN IN PATIENTS WITH ADVANCED TUMORS - A CANCER AND LEUKEMIA GROUP-B STUDY SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID TAXOL AB Purpose: To define the dose-limiting toxicities (DLTs) and the recommended phase II doses of paclitaxel combined with topotecan, without and with filgrastim support. Patients and Methods: patients with advanced solid tumors and a maximum of one prior chemotherapy regimen for metastatic disease were eligible if they herd a performance status of 0 to 1 and normal renal, hepatic, and bone marrow function, Prior treatment with taxanes or camptothecin analogs, and prior pelvic irradiation were not allowed, patients with a history of cardiac disease or on medications known to effect cardiac conduction were excluded, The dose of topotecan was fixed at 1.0 mg/m(2)/d for 5 days, The dose of paclitaxel was escalated until the maximum-tolerated dose (MTD), without and with filgrastim 5 mu g/kg subcutaneously (SC) on days 6 to 14, was reached, Paclitaxel was administered over 3 hours on day 1 before topotecan, Treatment cycles were repeated every 21 days, Results: Of 46 patients entered, 45 were assessable for toxicity and 34 for response, The principal toxicity was neutropenia Without filgrastim, the MTD of paclitaxel was 80 mg/m(2) on day 1 in combination with topotecan 1.0 mg/m(2)/d for 5 days. With filgrastim, the dose of paclitaxel wets escalated to 230 mg/m(2) in combination with the same dose of topotecan. At this dose level, one patient had hematologic DLT and a second patient developed neuromuscular DLT, Three patients had a partial response (PR): one with head and neck canter, a second with non-small cell lung cancer, and the third with colon cancer. Conclusion: We conclude that paclitaxel can be given at clinically relevant doses in combination with topotecan and filgrastim, The recommended dose for phase II studies is paclitaxel 230 mg/m(2) on day 1 and topotecan 1.0 mg/m(2)/day for 5 days with filgrastim 5 mu g/kg on days 6 to 14. (C) 1995 by American Society of Clinical Oncology. C1 UNIV CALIF SAN DIEGO,SAN DIEGO,CA 92103. UNIV CHICAGO,MED CTR,CHICAGO,IL 60637. UNIV TENNESSEE,MEMPHIS,TN. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. LEUKEMIA GRP B STAT OFF,DURHAM,NC. FU NCI NIH HHS [CA11789, CA41287, CA47555] NR 27 TC 56 Z9 58 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD SEP PY 1995 VL 13 IS 9 BP 2230 EP 2237 PG 8 WC Oncology SC Oncology GA RT917 UT WOS:A1995RT91700012 PM 7545219 ER PT J AU SCULLY, SP TEMPLE, HT OKEEFFE, RJ SCARBOROUGH, MT MANKIN, HJ GEBHARDT, MC AF SCULLY, SP TEMPLE, HT OKEEFFE, RJ SCARBOROUGH, MT MANKIN, HJ GEBHARDT, MC TI ROLE OF SURGICAL RESECTION IN PELVIC EWINGS-SARCOMA SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID THERAPY; BONE AB Purpose: The improved survival in patients with Ewing's sarcoma over the past two decades has placed increased importance on achievement of local disease control, Ewing's sarcoma that arises in the pelvis has been recognized to have a worse prognosis than that in the appendicular skeleton, and the role of surgical resection in these cases remains controversial. The current study attempts to identify a benefit to surgical resection in these patients. Methods: We retrospectively examined 39 patients who presented with Ewing's sarcoma in a pelvic location, all of whom were treated systemically with chemotherapy, Twenty patients received radiation only as a means of local control, and 19 underwent resection with or without radiation therapy, The patients were evaluated with end points of disease-free survival and overall survival for a minimum of 24 months and a mean of 58 months. Results: There was an even distribution among patients who underwent surgical resection for local control as compared with those who received only radiation therapy with respect to age, site, date of treatment, and stage of disease, Despite uncontrolled biases including tumor size and response to chemotherapy that would be expected to favor patients who undergo resection, surgery in addition to or in substitution for radiation therapy did not result in a statistically significant increase in disease-free survival or overall survival. Local disease control was comparable between those who underwent resection and those who did not: three patients in each group developed a local recurrence. Conclusion: Currently, morbidity of surgical resection should be weighed against the efficacy and secondary complications of radiation therapy in the decision-making process for local disease control, The issue of whether overall survival and local disease control is improved in patients who undergo surgical resection remains controversial and may require a prospective randomized trial to be answered definitively. (C) 1995 by American Society of Clinical Oncology. C1 MASSACHUSETTS GEN HOSP,ORTHOPAED ONCOL UNIT,BOSTON,MA. WALTER REED ARMY MED CTR,WASHINGTON,DC. UNIV FLORIDA,GAINESVILLE,FL. UNIV ROCHESTER,ROCHESTER,NY. RP SCULLY, SP (reprint author), DUKE UNIV,MED CTR,BOX 3312,DURHAM,NC 27710, USA. NR 20 TC 55 Z9 56 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD SEP PY 1995 VL 13 IS 9 BP 2336 EP 2341 PG 6 WC Oncology SC Oncology GA RT917 UT WOS:A1995RT91700026 PM 7666092 ER PT J AU LEENKNECHT, DA SHERLOCK, AR SZUWALSKI, A AF LEENKNECHT, DA SHERLOCK, AR SZUWALSKI, A TI AUTOMATED TOOLS FOR COASTAL ENGINEERING SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE COMPUTER PROGRAMS; WIND ADJUSTMENT; WAVE GROWTH, THEORY, AND TRANSFORMATION; STRUCTURAL DESIGN, RUNUP, TRANSMISSION, OVERTOPPING; LITTORAL AND INLET PROCESSES ID WAVE AB Coastal Engineering practice encompasses a substantial diversity of technologies varying in sophistication and origin. The U.S. Army Corps of Engineers requires interactive computer based design capabilities for this purpose. An overview is presented of the contents, history, usage and issues relative to a widely used collection of automated technologies for a variety of coastal engineering topics. RP LEENKNECHT, DA (reprint author), USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 72 TC 3 Z9 3 U1 0 U2 0 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD FAL PY 1995 VL 11 IS 4 BP 1108 EP 1124 PG 17 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA TB661 UT WOS:A1995TB66100013 ER PT J AU LEE, GH NICHOLLS, RJ BIRKEMEIER, WA LEATHERMAN, SP AF LEE, GH NICHOLLS, RJ BIRKEMEIER, WA LEATHERMAN, SP TI A CONCEPTUAL FAIRWEATHER STORM MODEL OF BEACH NEARSHORE PROFILE EVOLUTION AT DUCK, NORTH-CAROLINA, USA SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE SLOPE; COASTAL EROSION; SEDIMENT BUDGET; SHOREFACE ID SHOREFACE AB Limited long-term (decadal) beach-nearshore profile observations suggest that during fairweather conditions, the beach-nearshore slope gradually steepens while the shoreline remains relatively stable. The steepening process is terminated by an extreme storm event during which sand is carried offshore, the shoreline migrates landward and the beach-nearshore slope flattens. When the interval between storms is large, the profile approaches a maximum steepness and its susceptibility to erosion and shoreline recession is maximized. To test this conceptual fairweather/storm model, storm events were related to shoreline position, sediment volume and slope changes obtained from the high precision profile data at Duck, North Carolina Beach-nearshore profiles have been collected for 10 1/2 years at approximately biweekly intervals. Four major groups of storms occurred during the observation period. They all caused an abrupt increase in the volume of the upper shoreface; in two cases there was a net volume gain to the overall profile. During intervening fairweather conditions, there was a steady onshore transport of sand from the upper shoreface while the total volume remained constant. Slope changes, determined by linear regression of the upper shoreface, support the conceptual fairweather/storm model. Inclusion of the more landward element of the profile was difficult due to the presence of bars. The shoreline at Duck was insensitive to these offshore changes due to the coarse grain sire at the shoreline. However, other sites composed of finer-grained sediments might be expected to more sensitive to such changes. These results show that the fairweather/storm model may be a useful conceptual tool to examine medium- to long-term (years to many decades) beach-nearshore profile behavior. C1 UNIV MARYLAND,COASTAL RES LAB,COLLEGE PK,MD 20740. RP LEE, GH (reprint author), USA,ENGINEER WATERWAYS EXPT STN,FIELD RES FACIL,1261 DUCK RD,KITTY HAWK,NC 27949, USA. RI Nicholls, Robert/G-3898-2010 OI Nicholls, Robert/0000-0002-9715-1109 NR 16 TC 22 Z9 23 U1 0 U2 2 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD FAL PY 1995 VL 11 IS 4 BP 1157 EP 1166 PG 10 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA TB661 UT WOS:A1995TB66100017 ER PT J AU SMITH, JL JIN, L PARSONS, T TUREK, T RON, E PHILBROOK, CM KENLEY, RA MARDEN, L HOLLINGER, J BOSTROM, MPG TOMIN, E LANE, JM AF SMITH, JL JIN, L PARSONS, T TUREK, T RON, E PHILBROOK, CM KENLEY, RA MARDEN, L HOLLINGER, J BOSTROM, MPG TOMIN, E LANE, JM TI OSSEOUS REGENERATION IN PRECLINICAL MODELS USING BIOABSORBABLE DELIVERY TECHNOLOGY FOR RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2 (RHBMP-2) SO JOURNAL OF CONTROLLED RELEASE LA English DT Article; Proceedings Paper CT 3rd European Symposium on Controlled Drug Delivery CY APR 04-06, 1994 CL NOORDWIJK, NETHERLANDS SP 3M Medica GmbH, Germany, Astra Arcus AB, Sweden, Astra Hassle AB, Sweden, Ciba Geigy Ltd, US, Insutech Inc, US, Medisorb Technol Int LP, US, N V Organon Akzo Nobel, Netherlands, Pronova Biopolym a s, Norway, Rhone Poulenc Rorer SA, France, Sandoz Pharma Ltd, Switzerland, Yamanouchi Europe B V, Netherlands DE BONE REGENERATION; MORPHOGENETIC FACTOR; GROWTH FACTOR; ORTHOPEDICS; BIOABSORBABLE POLYMER AB Novel delivery systems for the bone morphogenetic protein rhBMP-2, consisting of poly(D,L-lactide-co-glycolide) porous microspheres as bioabsorbable filling material with either autologous blood clot or carboxymethylcellulose as binding agent, were tested in several preclinical models including a rat calvarial defect model, a rabbit radius segmental defect model, and a rabbit ulna segmental defect model. In the rat calvarial defect model, these novel delivery systems were shown to be comparable to inactivated collagenous bone matrix as a matrix for rhBMP-2 delivery at the appropriate dose. The incidence of union in the rabbit long bone studies exhibited a rhBMP-2 dose-response, achieving an incidence of union of nearly 100% at the higher doses tested. Histological evaluation showed remodelling of newly generated bone, and biomechanical testing found that the healed limbs were as strong as untreated control limbs. These studies demonstrate that it is possible to obtain osseous regeneration of critical-size defects by combining rhBMP-2 with synthetic delivery systems. C1 USA,WALTER REED ARMY MED CTR,INST DENT RES,WASHINGTON,DC 20307. HOSP SPECIAL SURG,NEW YORK,NY 10021. RP SMITH, JL (reprint author), INST GENET,1 BURTT RD,ANDOVER,MA 01810, USA. NR 19 TC 23 Z9 23 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-3659 J9 J CONTROL RELEASE JI J. Control. Release PD SEP PY 1995 VL 36 IS 1-2 BP 183 EP 195 DI 10.1016/0168-3659(95)00046-B PG 13 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Chemistry; Pharmacology & Pharmacy GA RV908 UT WOS:A1995RV90800017 ER PT J AU Zeid, AA Overholt, JL AF Zeid, AA Overholt, JL TI Singularly perturbed bond graph models for simulation of multibody systems SO JOURNAL OF DYNAMIC SYSTEMS MEASUREMENT AND CONTROL-TRANSACTIONS OF THE ASME LA English DT Article ID MECHANISMS; DYNAMICS AB This paper develops a bond graph-based formalism for modeling multibody systems in a singularly perturbed formulation. As opposed to classical multibody modeling methods, the singularly perturbed formulation is explicit, which makes it suitable for modular simulation. Kinematic joints that couple rigid bodies are described by a set of differential equations with an order of magnitude smaller time scale than that of the system. Singularly perturbed models of joints can be used to investigate nonlinear properties of joints, such as clearance and friction. The main restriction of this approach is that the simulation may need to be computed using 64 bits precision because of the two-time scale nature of the solution. The formalism is based on developing bond graph models of art elementary set of graphical velocity-based constraint functions. This set can be used to construct bond graphs of any type of mechanical joint. Here, this set is used to develop bond graphs of several joints used in multibody systems and spatial mechanisms. Complex models of multibody systems may now be built by graphically concatenating bond graphs of rigid bodies and bond graphs of joints. The dynamic equations of the system are automatically generated from the resulting bond graph model. The dynamic equation derived from the bond graph are in explicit state space form, ready for numerical integration, and exclude the computationally intensive terms that arise from acceleration analysis. C1 USA, TANK AUTOMOT COMMAND, WARREN, MI 48379 USA. RP AHPCRC, CSC, WARREN, MI 48090 USA. NR 34 TC 11 Z9 13 U1 0 U2 0 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0022-0434 EI 1528-9028 J9 J DYN SYST-T ASME JI J. Dyn. Syst. Meas. Control-Trans. ASME PD SEP PY 1995 VL 117 IS 3 BP 401 EP 410 DI 10.1115/1.2799131 PG 10 WC Automation & Control Systems; Instruments & Instrumentation SC Automation & Control Systems; Instruments & Instrumentation GA TT879 UT WOS:A1995TT87900018 ER PT J AU DHAR, NK WOOD, CEC BOYD, PR POLLEHN, HK MARTINKA, M BENSON, JD DINAN, JH AF DHAR, NK WOOD, CEC BOYD, PR POLLEHN, HK MARTINKA, M BENSON, JD DINAN, JH TI 2-DIMENSIONAL MOLECULAR-BEAM EPITAXY OF (001) CDTE ON CD AND ZN TERMINATED (001) GAAS SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 1994 US Workshop on the Physics and Chemistry of Mercury Cadmium Telluride and Other IR Materials CY OCT 04-06, 1994 CL SAN ANTONIO, TX DE CDTE/GAAS; GROWTH MODES; MOLECULAR BEAM EPITAXY (MBE) ID 100 ORIENTED GAAS; HETEROEPITAXIAL GROWTH; ORIENTATION; FILMS; TE; SUBSTRATE; LAYERS AB Amorphous layers of CdTe deposited on Cd or Zn terminated GaAs {001} surfaces can be recrystallized above similar to 200 degrees C. Subsequent molecular beam epitaxy of CdTe proceeds in a two-dimensional mode and leads to layers which are specular and single domain {001}. Threading dislocation density in these layers was 1-2 x 10(5) cm(-2). Values of full width at half maximum for x-ray rocking curves were as low as 80 arc-s. C1 UNIV MARYLAND,DEPT ELECT ENGN,COLLEGE PK,MD 20742. NIGHT VIS & ELECTR SENSORS DIRECTORATE,FT BELVOIR,VA 22060. RP DHAR, NK (reprint author), USA,RES LAB,FT BELVOIR,VA 22060, USA. RI Schaff, William/B-5839-2009 NR 22 TC 2 Z9 2 U1 0 U2 2 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 420 COMMONWEALTH DR, WARRENDALE, PA 15086 SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD SEP PY 1995 VL 24 IS 9 BP 1041 EP 1046 DI 10.1007/BF02653050 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA RR911 UT WOS:A1995RR91100002 ER PT J AU JAMES, WF BARKO, JW EAKIN, HL AF JAMES, WF BARKO, JW EAKIN, HL TI INTERNAL PHOSPHORUS LOADING IN LAKE PEPIN, UPPER MISSISSIPPI RIVER SO JOURNAL OF FRESHWATER ECOLOGY LA English DT Article ID PHOSPHATE RELEASE; SEDIMENTS; DIFFUSION; SHALLOW; WATER; PH AB We examined rates of internal phosphorus (P) loading from sediments in Lake Pepin, an impoundment on the upper Mississippi River. Laboratory-determined rates of P release from the sediment, measured using intact sediment core systems, were very high, with mean values ranging from 3.8 to 15 mg m(-2) d(-1) under oxic and anoxic conditions, respectively. Independently-determined Fickean diffusional fluxes (mean of 4.9 mg m(-2) d(-1)), measured in situ under oxic conditions using sediment peepers, were not statistically different from those rates determined in the laboratory under similar temperature, pH, and oxygen conditions. The dominant inorganic P fractions in the sediments were NaOH-extractable P and HCl-extractable P. Under both oxic and anoxic conditions, significant correlations existed between rates of P release and the NH4Cl- and NaOH-extractable P fractions, suggesting that loosely-bound and iron- and aluminum-bound sediment P contributed to P release from the sediments in this lake. Correlations between total sediment P and extractable sediment P fractions indicated that loosely-bound and iron- and aluminum-bound P increased, while calcium-bound P decreased, with increasing total P content of the sediment. Our results suggest that internal P loading from the sediments under oxic, as well as anoxic, conditions can play a very important role in the P economy of this system. C1 ENVIRONM MANAGEMENT TECH CTR,ONLASKA,WI 54650. RP JAMES, WF (reprint author), USA,ENGINEER WATERWAYS EXPT STN,EAU GALLE AQUAT ECOL LAB,SPRING VALLEY,WI 54767, USA. NR 24 TC 21 Z9 25 U1 0 U2 5 PU OIKOS PUBL INC PI LA CROSSE PA PO BOX 2558, LA CROSSE, WI 54601 SN 0270-5060 J9 J FRESHWATER ECOL JI J. Freshw. Ecol. PD SEP PY 1995 VL 10 IS 3 BP 269 EP 276 DI 10.1080/02705060.1995.9663446 PG 8 WC Ecology; Limnology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA RZ113 UT WOS:A1995RZ11300008 ER PT J AU GRATT, HJ MCCOWAN, WL AF GRATT, HJ MCCOWAN, WL TI FEEDBACK LINEARIZATION AUTOPILOT DESIGN FOR THE ADVANCED KINETIC-ENERGY MISSILE BOOST PHASE SO JOURNAL OF GUIDANCE CONTROL AND DYNAMICS LA English DT Article AB This paper describes an application of feedback linearization to the design of an autopilot for the boost phase of the advanced kinetic energy missile, a hypervelocity missile being developed by the U.S. Army Missile Command. The rapid change in missile states during the boost phase, coupled with a requirement for accurate guidance, provide a challenge for the autopilot designer. Application of the feedback linearization methodology permitted an autopilot design to be successfully accomplished without the necessity for generating numerous airframe transfer functions and frozen-point stability plots. The resulting autopilot is easily updated to accommodate changes in the missile design. C1 USA,MISSILE COMMAND,CTR RES DEV & ENGN,GUIDANCE & CONTROL ANAL BRANCH,REDSTONE ARSENAL,AL 35898. KBM ENTERPRISES INC,GUIDANCE & CONTROL,HUNTSVILLE,AL 35803. NR 11 TC 3 Z9 3 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0731-5090 J9 J GUID CONTROL DYNAM JI J. Guid. Control Dyn. PD SEP-OCT PY 1995 VL 18 IS 5 BP 945 EP 950 DI 10.2514/3.21489 PG 6 WC Engineering, Aerospace; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA RZ381 UT WOS:A1995RZ38100002 ER PT J AU CASSELS, FJ HUGHES, CV NAUSS, JL AF CASSELS, FJ HUGHES, CV NAUSS, JL TI ADHESIN RECEPTORS OF HUMAN ORAL BACTERIA AND MODELING OF PUTATIVE ADHESIN-BINDING DOMAINS SO JOURNAL OF INDUSTRIAL MICROBIOLOGY LA English DT Article DE ADHESIN RECEPTORS; STREPTOCOCCAL POLYSACCHARIDES; COAGGREGATION; SALIVARY PROTEINS; MOLECULAR MODELING ID PROLINE-RICH PROTEINS; CAPNOCYTOPHAGA-OCHRACEA ATCC-33596; MOLECULAR-DYNAMICS SIMULATIONS; HUMAN SALIVARY AGGLUTININ; SEROTYPE-C STRAINS; STREPTOCOCCUS-SANGUIS; ACTINOMYCES-NAESLUNDII; APATITIC SURFACES; TYPE-1 FIMBRIAE; FUSOBACTERIUM-NUCLEATUM AB Adherence by bacteria to a surface is critical to their survival in the human oral cavity, Many types of molecules are present in the saliva and serous exudates that form the acquired pellicle, a coating on the tooth surface, and serve as receptor molecules for adherent bacteria. The primary colonizing bacteria utilize adhesins to adhere to specific pellicle receptor molecules, then may adhere to other primary colonizers via adhesins, or may present receptor molecules to be utilized by secondary colonizing species. The most common primary colonizing bacteria are streptococci, and six streptococcal cell wall polysaccharide receptor molecules have been structurally characterized. A comparison of the putative adhesin disaccharide-binding regions of the six polysaccharides suggests three groups, A representative of each group was modeled in molecular dynamics simulations, In each case it was found that a loop formed between the galactofuranose beta (Galf beta) and an oxygen of the nearest phosphate group on the reducing side of the Galf beta, that this loop was stabilized by hydrogen bonds, and that within each loop resides the putative disaccharide-binding domain. C1 BOSTON UNIV, DEPT PEDIAT DENT, BOSTON, MA 02118 USA. UNIV CINCINNATI, DEPT CHEM, CINCINNATI, OH 45221 USA. RP CASSELS, FJ (reprint author), WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, DEPT GASTROENTEROL, DIV MED, WASHINGTON, DC 20307 USA. RI Hughes, Christopher/E-1438-2014 NR 92 TC 14 Z9 15 U1 0 U2 0 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE RG21 6XS, HAMPSHIRE, ENGLAND SN 0169-4146 J9 J IND MICROBIOL JI J. Indust. Microbiol. PD SEP PY 1995 VL 15 IS 3 BP 176 EP 185 DI 10.1007/BF01569823 PG 10 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA TA263 UT WOS:A1995TA26300009 PM 8519475 ER PT J AU CASSELS, FJ WOLF, MK AF CASSELS, FJ WOLF, MK TI COLONIZATION FACTORS OF DIARRHEAGENIC ESCHERICHIA-COLI AND THEIR INTESTINAL RECEPTORS SO JOURNAL OF INDUSTRIAL MICROBIOLOGY LA English DT Review DE COLONIZATION FACTORS; INTESTINAL RECEPTORS; DIARRHEAGENIC ESCHERICHIA-COLI; ENTEROTOXIGENIC ESCHERICHIA-COLI; FIMBRIAE; ADHESINS ID TOXIGENIC ESCHERICHIA-COLI; FACTOR ANTIGEN-I; BUNDLE-FORMING PILUS; ENTERO-TOXIN TYPE; NUCLEOTIDE-SEQUENCE; ERYTHROCYTE RECEPTOR; SURFACE ANTIGEN-4; REGULATORY GENE; K99 FIMBRIAE; AF/R1 PILI AB While Escherichia coli is common as a commensal organism in the distal ileum and colon, the presence of colonization factors (CF) on pathogenic strains of E. coli facilitates attachment of the organism to intestinal receptor molecules in a species- and tissue-specific fashion. After the initial adherence, colonization occurs, and the involvement of additional virulence determinants leads to illness, Enterotoxigenic E. coli(ETEC) is the most extensively studied of the five categories of E. coli that cause diarrheal disease, and has the greatest impact on health worldwide, ETEC can be isolated from domestic animals and humans, The biochemistry, genetics, epidemiology, antigenic characteristics, and cell and receptor binding properties of ETEC have been extensively described, Another major category, enteropathogenic E. coli (EPEC), has virulence mechanisms, primarily effacement and cytoskeletal rearrangement of intestinal brush borders, that are distinct from ETEC, An EPEC CF receptor has been purified and characterized as a sialidated transmembrane glycoprotein complex directly attached to actin, thereby associating CF-binding with host-cell response. Three additional categories of E. coli diarrheal disease, their colonization factors and their host cell receptors, are discussed. It appears that biofilms exist in the intestine in a manner similar to oral bacterial biofilms, and that E. coli is part of these biofilms as both commensals and pathogens. RP CASSELS, FJ (reprint author), WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, DEPT GASTROENTEROL, DIV MED, WASHINGTON, DC 20307 USA. NR 167 TC 60 Z9 62 U1 3 U2 15 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE RG21 6XS, HAMPSHIRE, ENGLAND SN 0169-4146 J9 J IND MICROBIOL JI J. Indust. Microbiol. PD SEP PY 1995 VL 15 IS 3 BP 214 EP 226 DI 10.1007/BF01569828 PG 13 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA TA263 UT WOS:A1995TA26300014 PM 8519480 ER PT J AU HO, M SEXTON, MM TONGTAWE, P LOOAREESUWAN, S SUNTHARASAMAI, P WEBSTER, HK AF HO, M SEXTON, MM TONGTAWE, P LOOAREESUWAN, S SUNTHARASAMAI, P WEBSTER, HK TI INTERLEUKIN-10 INHIBITS TUMOR-NECROSIS-FACTOR PRODUCTION BUT NOT ANTIGEN-SPECIFIC LYMPHOPROLIFERATION IN ACUTE PLASMODIUM-FALCIPARUM MALARIA SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID T-CELL CLONES; CYTOKINE PRODUCTION; CEREBRAL MALARIA; INTERFERON-GAMMA; IL-10; PROLIFERATION; INFECTION; SUBSETS; INVITRO; INVIVO AB In vivo interleukin (IL)-2, IL-4, IL-10, and interferon (IFN)-gamma production was measured at the mRNA transcript and protein levels in patients acutely infected with Plasmodium falciparum and during convalescence. Both IL-10 and IFN-gamma but not IL-2 were produced regardless of the patients' clinical severity, IL-4 production was variable. Circulating IFN-gamma and IL-10 were significantly higher in patients with severe disease (P < .01 and .001, respectively). In vitro stimulation of peripheral blood mononuclear cells (PBMC) by malarial antigens during acute infection showed that although there was no lymphoproliferation, the cells could produce IL-10 and IFN-gamma. Recombinant human IL-10 completely abolished in vitro tumor necrosis factor (TNF)-alpha production in response to malarial antigens, as web as the antigen-specific proliferative response of convalescent patients. However, anti-IL-10 was insufficient to restore proliferation of PBMC from acutely infected patients. These findings suggest that IL-10 may have an important negative feedback action on the production of inflammatory cytokines in acute falciparum malaria without contributing to the defect in antigen-specific proliferation. C1 MAHIDOL UNIV,HOSP TROP DIS,FAC TROP MED,DEPT CLIN TROP MED,BANGKOK 10700,THAILAND. ARMED FORCES RES INST MED SCI,USA COMPONENT,BANGKOK 10400,THAILAND. RP HO, M (reprint author), UNIV CALGARY,HLTH SCI CTR,DEPT MICROBIOL & INFECT DIS,3330 HOSP DR NW,CALGARY,AB T2N 4N1,CANADA. NR 44 TC 80 Z9 81 U1 1 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD SEP PY 1995 VL 172 IS 3 BP 838 EP 844 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA RR073 UT WOS:A1995RR07300030 PM 7658079 ER PT J AU WILSON, RA SONGER, AD DIEKMANN, J AF WILSON, RA SONGER, AD DIEKMANN, J TI PARTNERING - MORE THAN A WORKSHOP, A CATALYST FOR CHANGE SO JOURNAL OF MANAGEMENT IN ENGINEERING LA English DT Article AB Partnering is an increasingly popular management tool aimed at reversing the negative affects of adversarial relationships in construction. Currently, partnering in the construction industry focuses on a project by project implementation effort. However, this approach does not address the organizational changes required to fully internalize partnering into a construction corporate culture. Many organizational behaviorists agree that a cultural change must be managed. However, it is usually a difficult venture that must be carefully considered and cautiously undertaken (Frost 1985). This paper investigates partnering from a strategic viewpoint. It imbeds the strategic aspect of a partnering process into a modern organizational-change model. The resulting partnering process model serves as a guide for those construction organizations preparing to partner or those currently partnering with a desire to internalize their concepts and values. C1 UNIV COLORADO,DEPT CIVIL ENGN,BOULDER,CO 80309. RP WILSON, RA (reprint author), USA,CORPS ENGINEERS,HUNTINGTON,WV 25701, USA. NR 27 TC 23 Z9 23 U1 0 U2 6 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0742-597X J9 J MANAGE ENG JI J. Manage. Eng. PD SEP-OCT PY 1995 VL 11 IS 5 BP 40 EP 45 DI 10.1061/(ASCE)0742-597X(1995)11:5(40) PG 6 WC Engineering, Industrial; Engineering, Civil SC Engineering GA RQ838 UT WOS:A1995RQ83800017 ER PT J AU WILKERSON, RC PARSONS, TJ KLEIN, TA GAFFIGAN, TV BERGO, E CONSOLIM, J AF WILKERSON, RC PARSONS, TJ KLEIN, TA GAFFIGAN, TV BERGO, E CONSOLIM, J TI DIAGNOSIS BY RANDOM AMPLIFIED POLYMORPHIC DNA-POLYMERASE CHAIN-REACTION OF 4 CRYPTIC SPECIES-RELATED TO ANOPHELES (NYSSORHYNCHUS) ALBITARSIS (DIPTERA, CULICIDAE) FROM PARAGUAY, ARGENTINA, AND BRAZIL SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE ANOPHELES (NYSSORHYNCHUS) ALBITARSIS SPECIES COMPLEX; RANDOM AMPLIFIED POLYMORPHIC DNA; MALARIA VECTORS ID ARBITRARY PRIMERS; POPULATIONS; COMPLEX; MARKERS; PCR AB Random amplified polymorphic DNA polymerase chain reaction (RAPD-PCR) analysis was applied to samples from widespread populations of the poorly characterized Anopheles (Nyssorhynchus) albitarsis Lynch-Arribalzaga species complex, and 4 genetically differentiated species were distinguished A screen of 65 random decamer oligonucleotide primers identified 12 primers, which produced 19 reproducible species-specific genetic markers and 4 markers common to 2 or more species. These markers were correlated in nearly all individuals of each species throughout the ranges sampled, including populations as far apart as 2,500 km. Each individual analyzed tvas from a different isofemale progeny brood, with associated morphological specimens. These specimens will facilitate studies to relate these species to previously reported chromosomal and enzymatic variation as well as to their feeding behavior and potential as malaria vectors. We hypothesize that 3 of the species have recognized valid names: An. (Nys.) albitarsis Lynch-Arribalzaga, An. (Nys.) marajoara Galvao and Damasceno, and An. (Nys.) deaneorum Rosa-Freitas, whereas the 4th is undescribed. RP WILKERSON, RC (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307, USA. NR 26 TC 81 Z9 85 U1 0 U2 3 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD SEP PY 1995 VL 32 IS 5 BP 697 EP 704 PG 8 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA RT608 UT WOS:A1995RT60800017 PM 7473625 ER PT J AU DALSGAARD, A SERICHANTALERGS, O SHIMADA, T SETHABUTR, O ECHEVERRIA, P AF DALSGAARD, A SERICHANTALERGS, O SHIMADA, T SETHABUTR, O ECHEVERRIA, P TI PREVALENCE OF VIBRIO-CHOLERAE WITH HEAT-STABLE ENTEROTOXIN (NAG-ST) AND CHOLERA-TOXIN GENES - RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISMS OF NAG-ST GENES AMONG VIBRIO-CHOLERAE O-SEROGROUPS FROM A MAJOR SHRIMP PRODUCTION AREA IN THAILAND SO JOURNAL OF MEDICAL MICROBIOLOGY LA English DT Article ID OLIGONUCLEOTIDE PROBE; ESCHERICHIA-COLI; NON-O1; INDIA; DNA; PURIFICATION; STRAINS; GASTROENTERITIS; TRAVELERS; CALCUTTA AB A total of 148 Vibrio cholerae isolates from a major shrimp production area in Southern Thailand were examined by colony hybridisation for genes encoding heat-stable enterotoxin (NAG-ST) and cholera toxin (CT). Only non-O1 V. cholerae strains were found to harbour NAG-ST (14 of 146) whereas no strains hybridised with the CT probe. NAG-ST-positive V. cholerae non-O1 strains were isolated from shrimp farms situated close to urban areas. Five different O serogroups were found among NAG-ST positive non-O1 strains. Southern blot and restriction endonuclease analysis of NAG-ST-positive strains revealed a high degree of genetic divergence. A total of seven classes of enterotoxin gene patterns were found with HindIII and EcoRI restriction endonucleases. Enterotoxin gene patterns correlated with O-antigen expression in 84% of isolates tested. In combination with other molecular techniques Southern blot analysis with an NAG-ST oligonucleotide probe could be useful for studying the molecular epidemiology of V. cholerae non-O1 strains. C1 ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. NIH,DEPT BACTERIOL,SHINJUKU KU,TOKYO 162,JAPAN. RP DALSGAARD, A (reprint author), ROYAL VET & AGR UNIV,DEPT VET MICROBIOL,FISH DIS SECT,13 BULOWSVEJ,DK-1870 FREDERIKSBERG C,DENMARK. NR 32 TC 19 Z9 21 U1 0 U2 0 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH, MIDLOTHIAN, SCOTLAND EH1 3AF SN 0022-2615 J9 J MED MICROBIOL JI J. Med. Microbiol. PD SEP PY 1995 VL 43 IS 3 BP 216 EP 220 PG 5 WC Microbiology SC Microbiology GA RQ379 UT WOS:A1995RQ37900009 PM 7650730 ER PT J AU BAKER, JT BORRIS, RP CARTE, B CORDELL, GA SOEJARTO, DD CRAGG, GM GUPTA, MP IWU, MM MADULID, DR TYLER, VE AF BAKER, JT BORRIS, RP CARTE, B CORDELL, GA SOEJARTO, DD CRAGG, GM GUPTA, MP IWU, MM MADULID, DR TYLER, VE TI NATURAL PRODUCT DRUG DISCOVERY AND DEVELOPMENT - NEW PERSPECTIVES ON INTERNATIONAL COLLABORATION SO JOURNAL OF NATURAL PRODUCTS-LLOYDIA LA English DT Article ID MEDICINAL-PLANTS; IN-VIVO AB Until recently, the prevailing attitude in developed nations regarded the world's genetic resources, which are mainly concentrated in the developing world, as a common resource of humankind, to be exploited freely irrespective of national origin. With the devastation being wreaked in the tropical rainforests and the resurgence in interest in recent years in the discovery of novel drugs from natural sources, particularly plants and marine organisms, the international scientific community has realized that the conservation of these global genetic resources and the indigenous knowledge associated with their use are of primary importance if their potential is to be fully explored. With this realization has come a recognition that these goals must be achieved through collaboration with, and fair and equitable compensation of, the scientists and communities of the genetically rich source countries. The signing of the United Nations Convention on Biological Diversity by nearly all of the world's nations has emphasized the need for the implementation of such policies. In this review, the articles of the Convention of relevance to the activities and practices of the natural products scientific community are briefly discussed. This discussion is followed by a summary of policies for international collaboration and compensation being implemented by several developed country organizations, and the perspectives on the current developments given by representatives of some of the source countries located in the regions of greatest biodiversity. C1 AUSTRALIAN INST MARINE SCI,TOWNSVILLE,QLD 4810,AUSTRALIA. MERCK RES LABS,RAHWAY,NJ 07065. SMITHKLINE BEECHAM PHARMACEUT,KING OF PRUSSIA,PA 19406. UNIV ILLINOIS,COLL PHARM,DEPT MED CHEM & PHARMACOGNOSY,PROGRAM COLLABORAT RES PHARMACEUT SCI,CHICAGO,IL 60612. NCI,FREDERICK CANC RES & DEV CTR,DIV CANC TREATMENT,DEV THERAPEUT PROGRAM,NAT PROD BRANCH,FREDERICK,MD 21702. UNIV PANAMA,COLL PHARM,CTR PHARMACOGNOST RES PANAMANIAN FLORA,PANAMA CITY,PANAMA. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NATL MUSEUM,DIV BOT,MANILA,PHILIPPINES. PURDUE UNIV,SCH PHARM & PHARMACEUT SCI,DEPT MED CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907. RI Borris, Robert/K-1095-2015; OI Borris, Robert/0000-0002-5317-7382; Gupta, Mahabir/0000-0002-9302-7864 NR 44 TC 128 Z9 136 U1 1 U2 13 PU AMER SOC PHARMACOGNOSY PI CINCINNATI PA LLOYD LIBRARY & MUSEUM 917 PLUM ST, CINCINNATI, OH 45202 SN 0163-3864 J9 J NAT PRODUCTS JI J. Nat. Prod. PD SEP PY 1995 VL 58 IS 9 BP 1325 EP 1357 DI 10.1021/np50123a003 PG 33 WC Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy SC Plant Sciences; Pharmacology & Pharmacy GA TB928 UT WOS:A1995TB92800003 PM 7494142 ER PT J AU BALLOUGH, GPH MARTIN, LJ CANN, FJ GRAHAM, JS SMITH, CD KLING, CE FORSTER, JS PHANN, S FILBERT, MG AF BALLOUGH, GPH MARTIN, LJ CANN, FJ GRAHAM, JS SMITH, CD KLING, CE FORSTER, JS PHANN, S FILBERT, MG TI MICROTUBULE-ASSOCIATED PROTEIN 2(MAP-2) - A SENSITIVE MARKER OF SEIZURE-RELATED BRAIN-DAMAGE SO JOURNAL OF NEUROSCIENCE METHODS LA English DT Article DE MICROTUBULE-ASSOCIATED PROTEIN-2; SEIZURE; NEUROTOXICITY; SOMAN; GFAP; CRESYL VIOLET; HEMATOXYLIN; EOSIN ID RAT-BRAIN; ACUTE NEUROPATHOLOGY; POISONED RATS; CALPAIN-I; SOMAN; NEUROTOXICITY; DEGENERATION; ACRYLAMIDE; DEPENDENCE; COMPOUND AB We have assessed the efficacy of MAP-2 immunohistochemistry as a marker of seizure-related brain damage and its suitability for quantitation of the damage using densitometric and morphometric image analysis. Seizures were produced in rats by administration of 1.5 LD(50) soman, an irreversible AChE inhibitor. Our results demonstrate that neuronal damage, assessed using hematoxylin and eosin, and cresyl violet staining, was colocalized on adjacent serial sections with clearly demarcated reductions in MAP-2 staining. The most severely damaged brain regions were devoid of MAP-2 staining. Reductions in MAP-2 immunostaining were found to be exceptionally well suited for quantitation using densitometric and morphometric image analysis. This study represents the first demonstration of seizure-induced excitotoxic alterations in MAP-2. C1 USA,MED RES INST CHEM DEF,DIV PATHOPHYSIOL,NEUROTOXICOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. JOHNS HOPKINS UNIV,SCH MED,DEPT PATHOL,BALTIMORE,MD 21205. JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205. LA SALLE UNIV,DEPT BIOL,PHILADELPHIA,PA 19141. NR 32 TC 40 Z9 43 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-0270 J9 J NEUROSCI METH JI J. Neurosci. Methods PD SEP-OCT PY 1995 VL 61 IS 1-2 BP 23 EP 32 DI 10.1016/0165-0270(95)00019-Q PG 10 WC Biochemical Research Methods; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA TG023 UT WOS:A1995TG02300005 PM 8618422 ER PT J AU OLSON, RK CONNELLY, LM AF OLSON, RK CONNELLY, LM TI MENTORING THROUGH PREDOCTORAL FELLOWSHIPS TO ENHANCE RESEARCH PRODUCTIVITY SO JOURNAL OF PROFESSIONAL NURSING LA English DT Article DE MENTORING; NURSING STUDENTS; PREDOCTORAL FELLOWSHIPS; RESEARCH AB This article reports a study of the mentoring relationships that developed during predoctoral fellowships awarded to five nursing students who worked with faculty mentors at the University of Kansas, School of Nursing. Data were gathered through interviews and a written questionnaire from each of eight study participants (four of the five pairs). The analysis of interview and questionnaire data supported the existence of a mentoring relationship according to Yoder's (1990) model of mentoring, with the addition of two variables, socialization as a researcher and mutual sharing, that are unique to doctoral education. Themes that represented the experience of the mentor-protege pairs were identified: (1) productivity, (2) work organization, (3) mutual learning, (4) problems encountered, (5) beneficial research application skills, and (6) innovative communication. All participants were enthusiastic about the experience, and students indicated increased confidence in application of the research process. C1 UNIV KANSAS,KANSAS CITY,KS. BROOKE ARMY MED CTR,HOUSTON,TX. RP OLSON, RK (reprint author), S DAKOTA STATE UNIV,COLL NURSING,BOX 2275,BROOKINGS,SD 57007, USA. NR 16 TC 14 Z9 14 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 8755-7223 J9 J PROF NURS JI J. Prof. Nurs. PD SEP-OCT PY 1995 VL 11 IS 5 BP 270 EP 275 DI 10.1016/S8755-7223(05)80007-9 PG 6 WC Nursing SC Nursing GA RU658 UT WOS:A1995RU65800007 PM 7593970 ER PT J AU SAHU, J NIETUBICZ, CJ AF SAHU, J NIETUBICZ, CJ TI APPLICATION OF CHIMERA TECHNIQUE TO PROJECTILES IN RELATIVE MOTION SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article ID COMPUTATIONS; FLOW AB This article describes the application of the versatile chimera numerical technique to a time-dependent, mutli-body projectile configuration. A computational study was performed to determine the aerodynamics of small cylindrical segments ejected into the wake of a flared projectile. The complexity and uniqueness of this problem result from the segments being in relative motion, embedded in a nonuniform wake flow, and requiring a time-dependent solution. Flowfield computations for this problem have been performed for supersonic conditions. The predicted flowfield over the segments was found to undergo significant changes as the segments separated from the parent projectile. Comparison of the unsteady chimera results with the quasistatic approach shows the difference in drag to be significant, which indicates the need for time-dependent solution techniques. A subsequent experimental program was conducted, and the computed segment positions and velocities were found to be in good agreement with the experimental data. RP SAHU, J (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 22 TC 4 Z9 4 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0022-4650 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD SEP-OCT PY 1995 VL 32 IS 5 BP 795 EP 800 DI 10.2514/3.26686 PG 6 WC Engineering, Aerospace SC Engineering GA TC857 UT WOS:A1995TC85700009 ER PT J AU CHOWDHURY, MR RAY, JC AF CHOWDHURY, MR RAY, JC TI FURTHER CONSIDERATIONS FOR NONLINEAR FINITE-ELEMENT ANALYSIS SO JOURNAL OF STRUCTURAL ENGINEERING-ASCE LA English DT Note AB The results from a nonlinear finite-element analysis (NLFEA) of a reinforced concrete (RC) slab bridge are presented and discussed. The analytical results are compared with those obtained in 1993 by Huria Lee and Aktan and their differences are discussed. The analytical results are also compared in general to experimental results on a similar structure, as presented by Aktan, Zwick, Miller and Sharooz in 1992. The analyses predicted approximately the same ultimate failure load as that experienced by the bridge, but the failure mechanisms differed. All of the differences mentioned are used as the basis for additional recommendations to practicing engineers for conducting NLFEA of RC structures. RP CHOWDHURY, MR (reprint author), USA,ENGINEER WATERWAYS EXPT STN,STRUCT LAB,VICKSBURG,MS 39180, USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9445 J9 J STRUCT ENG-ASCE JI J. Struct. Eng.-ASCE PD SEP PY 1995 VL 121 IS 9 BP 1377 EP 1379 DI 10.1061/(ASCE)0733-9445(1995)121:9(1377) PG 3 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA RQ544 UT WOS:A1995RQ54400017 ER PT J AU PERICH, MJ WELLS, C BERTSCH, W TREDWAY, KE AF PERICH, MJ WELLS, C BERTSCH, W TREDWAY, KE TI ISOLATION OF THE INSECTICIDAL COMPONENTS OF TAGETES MINUTA (COMPOSITAE) AGAINST MOSQUITO LARVAE AND ADULTS SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article AB Application of Tagetes minuta floral extract to silica gel column chromatography produced 2 fractions with the hydrogenate part 20-30 times more toxic to larvae and 12-13 times more toxic to adults of Aedes aegypti and Anopheles stephensi, respectively, than the oxygenate part. Further fractionation by column chromatography of the hydrogenate fraction produced 4 thiophenes, 5-(but-3-ene-1-ynyl)-2,2'-bithiophene, 5-(but-3-ene-1-ynyl)-5'-methyl-2,2'-bithiophene, 2,2',5',2 ''-terthiophene, and 5-methyl-2,2',5',2 ''-terthiophene. These compounds in Tagetes minuta are largely responsible for the toxicity exhibited against the tested mosquitoes. C1 UNIV ALABAMA,DEPT CHEM,TUSCALOOSA,AL 35487. MONSANTO CHEM CORP,DECATUR,AL 35602. USA,BIOMED RES & DEV LAB,FREDERICK,MD 21702. RP PERICH, MJ (reprint author), WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307, USA. NR 9 TC 52 Z9 64 U1 0 U2 3 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD SEP PY 1995 VL 11 IS 3 BP 307 EP 310 PG 4 WC Entomology SC Entomology GA RW376 UT WOS:A1995RW37600003 PM 8551298 ER PT J AU BAIMAI, V RATTANARITHIKUL, R KIJCHALAO, U AF BAIMAI, V RATTANARITHIKUL, R KIJCHALAO, U TI METAPHASE KARYOTYPES OF ANOPHELES OF THAILAND AND SOUTHEAST-ASIA .4. THE BARBIROSTRIS AND UMBROSUS SPECIES GROUPS, SUBGENUS ANOPHELES (DIPTERA, CULICIDAE) SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article ID HETEROCHROMATIN AB Metaphase karyotypes of 2 and 3 species of the Umbrosus and the Barbirostris Groups, respectively, of the subgenus Anopheles occurring in Thailand and Indonesia show inter- and intraspecific differences with respect to the amount and distribution of constitutive heterochromatin in the sex chromosomes and/or autosomes. Four forms of metaphase karyotypes have been recognized in the wild samples of Anopheles barbirostris based on differences in size and shape of X and Y chromosomes. It is not known whether forms A, B, and C of the metaphase karyotype of An. barbirostris found in Thailand represent inter- or intraspecific differences. However, form D, which occurs only in Indonesia, may represent a mitotic karyotype of a distinct species closely related to An. barbirostris. Anopheles campestris and An. barbumbrosus are each readily separated from An. barbirostris by mitotic chromosomes. Anopheles umbrosus and An. letifer of the Umbrosus Group also exhibit heterochromatin variation in the X chromosomes. These 2 species can be readily distinguished by the gross morphology of mitotic karyotypes, particularly the X and Y chromosomes. C1 USA,MED COMPONENT,ARMED FORCES RES INST MED SCI,DEPT MED ENTOMOL,BANGKOK 10400,THAILAND. RP BAIMAI, V (reprint author), MAHIDOL UNIV,FAC SCI,DEPT BIOL,RAMA VI RD,BANGKOK 10400,THAILAND. NR 12 TC 15 Z9 15 U1 0 U2 0 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD SEP PY 1995 VL 11 IS 3 BP 323 EP 328 PG 6 WC Entomology SC Entomology GA RW376 UT WOS:A1995RW37600006 PM 8551301 ER PT J AU YUAN, C BOHEN, E CAROME, M AF YUAN, C BOHEN, E CAROME, M TI BETAINE EXPOSURE INHIBITS HEAT SHOCK-INDUCED UP-REGULATION OF HSP70 PROTEIN AND SUBSEQUENT TOLERANCE TO CYCLOSPORINE TOXICITY IN LLC-PK1 CELLS SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,SERV NEPHROL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD SEP PY 1995 VL 6 IS 3 SI SI BP 371 EP 371 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA RX686 UT WOS:A1995RX68600275 ER PT J AU SMITH, AC ABBOTT, K BAKRIS, GL AF SMITH, AC ABBOTT, K BAKRIS, GL TI SODIUM-INTAKE DETERMINES THE DEGREE OF ALBUMINURIA REDUCTION WITH CERTAIN CALCIUM-ANTAGONISTS SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Meeting Abstract C1 RUSH UNIV,CTR HYPERTENS,CHICAGO,IL 60612. BROOKE ARMY MED CTR,SAN ANTONIO,TX. NR 1 TC 1 Z9 1 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD SEP PY 1995 VL 6 IS 3 SI SI BP 650 EP 650 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA RX686 UT WOS:A1995RX68601389 ER PT J AU BOHEN, EM YUAN, CM CAROME, MA AF BOHEN, EM YUAN, CM CAROME, MA TI HYDROGEN-PEROXIDE INDUCES HSP70 GENE-EXPRESSION AND PROTECTS AGAINST SUBSEQUENT H2O2 OR CYCLOSPORINE (CYA) TOXICITY IN LLC-PK1 CELLS SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,SERV NEPHROL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD SEP PY 1995 VL 6 IS 3 SI SI BP 974 EP 974 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA RX686 UT WOS:A1995RX68602684 ER PT J AU CAROME, MA BOHEN, EM YUAN, CM AF CAROME, MA BOHEN, EM YUAN, CM TI ARACHIDONIC-ACID (AA) INDUCES HSP70 GENE-EXPRESSION BUT FAILS TO INDUCE TOLERANCE TO SUBSEQUENT TOXIN EXPOSURE IN LLC-PK1 CELLS SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,SERV NEPHROL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD SEP PY 1995 VL 6 IS 3 SI SI BP 975 EP 975 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA RX686 UT WOS:A1995RX68602688 ER PT J AU CAROME, MA BOHEN, EM YUAN, CM AF CAROME, MA BOHEN, EM YUAN, CM TI HEAT-SHOCK INDUCES TOLERANCE AGAINST SUBSEQUENT HYDROGEN-PEROXIDE EXPOSURE BUT NOT AGAINST ARACHIDONIC-ACID TOXICITY IN LLC-PK1 CELLS SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,NEPHROL SECT,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD SEP PY 1995 VL 6 IS 3 SI SI BP 975 EP 975 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA RX686 UT WOS:A1995RX68602689 ER PT J AU CAROME, MA BOHEN, EM SABNIS, S YUAN, CM AF CAROME, MA BOHEN, EM SABNIS, S YUAN, CM TI THE EFFECT OF GLYCINE ON CISPLATIN NEPHROTOXICITY AND HEAT-SHOCK-PROTEIN-70 EXPRESSION IN THE RAT-KIDNEY SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,NEPHROL SERV,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,WASHINGTON,DC. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD SEP PY 1995 VL 6 IS 3 SI SI BP 985 EP 985 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA RX686 UT WOS:A1995RX68602727 ER PT J AU PISEL, GA YUAN, CM CAROME, MA AF PISEL, GA YUAN, CM CAROME, MA TI INDUCTION OF THE HEAT-SHOCK RESPONSE PROTECTS CULTURED HUMAN RENAL PROXIMAL TUBULAR (HRPT) CELLS FROM CYCLOSPORINE-A (CYA) TOXICITY SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,NEPHROL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD SEP PY 1995 VL 6 IS 3 SI SI BP 1063 EP 1063 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA RX686 UT WOS:A1995RX68603038 ER PT J AU YUAN, CM BOHEN, EM CAROME, MA AF YUAN, CM BOHEN, EM CAROME, MA TI CYCLOSPORINE (CYA) INDUCES HSP70 GENE-EXPRESSION AND PROTECTS AGAINST SUBSEQUENT CYA TOXICITY IN LLC-PK1 CELLS SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DIV NEPHROL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD SEP PY 1995 VL 6 IS 3 SI SI BP 1067 EP 1067 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA RX686 UT WOS:A1995RX68603054 ER PT J AU DUFEY, DG AF DUFEY, DG TI TRANSIENT STRATOSPHERIC PLANETARY-WAVES GENERATED BY TROPOSPHERIC FORCING SO JOURNAL OF THE ATMOSPHERIC SCIENCES LA English DT Article ID SOUTHERN WINTER TROPOSPHERE; BAROCLINIC INSTABILITY; VERTICAL PROPAGATION; HEMISPHERE; STRATAN AB In this paper the tropospheric-stratospheric system is modeled as a two-layer, quasigeostrophic atmosphere, and the modal and nonmodal solutions that arise from an impulse forcing within the troposphere are found. Regardless of the nature of the zonal how, the troposphere can support disturbances over a broad range of wavenumbers, whereas the stratospheric solutions have significant amplitudes only at low wavenumbers. The results are applied to observational data given by a tropospheric-stratospheric analysis. It is shown that explosive baroclinic disturbances within the troposphere can generate transient waves within the stratosphere. RP DUFEY, DG (reprint author), US MIL ACAD,DEPT MATH SCI,W POINT,NY 10996, USA. NR 25 TC 0 Z9 0 U1 0 U2 0 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 SN 0022-4928 J9 J ATMOS SCI JI J. Atmos. Sci. PD SEP 1 PY 1995 VL 52 IS 17 BP 3109 EP 3128 PG 20 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA RR005 UT WOS:A1995RR00500004 ER PT J AU FLEMISH, JR XIE, K DU, H WITHROW, SP AF FLEMISH, JR XIE, K DU, H WITHROW, SP TI ION-IMPLANTATION AND ACTIVATION OF ALUMINUM IN 6H-SIC SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Letter ID SILICON-CARBIDE; NITROGEN; DIODES; BORON AB Ion implantation of large doses (> 10(15)/cm(2)) or Al into SIC is known to produce excessive damage which cannot be readily eliminated by thermal annealing. We have demonstrated electrical activation of ion-implanted Al in 6H-SiC, using a relatively low total ion dose (2.9 x 10(14)/cm(2)) implanted at three energies (65, 135, and 220 keV) into a 2 mu m epitaxial layer with a background p-type doping level of 1 x 10(18)/cm(3). The implanted samples were annealed at temperatures from 1300 to 1500 degrees C using a proximity annealing method to retard the decomposition of the SiC surface at high temperatures. Upon annealing at 1450 degrees C the sheet resistance of the implanted layer was reduced by approximately a factor of four relative to the same p-type layer which was not implanted. C1 STEVENS INST TECHNOL,DEPT MAT SCI & ENGN,HOBOKEN,NJ 07030. OAK RIDGE NATL LAB,OAK RIDGE,TN 37831. RP FLEMISH, JR (reprint author), USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703, USA. NR 14 TC 4 Z9 4 U1 0 U2 1 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD SEP PY 1995 VL 142 IS 9 BP L144 EP L146 DI 10.1149/1.2048727 PG 3 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA RV179 UT WOS:A1995RV17900003 ER PT J AU CHANDRA, AMS QUALLS, CW REDDY, G MEINKOTH, JH AF CHANDRA, AMS QUALLS, CW REDDY, G MEINKOTH, JH TI HEMATOLOGICAL EFFECTS OF 1,3,5-TRINITROBENZENE (TNB) IN RATS IN-VIVO AND IN-VITRO SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH LA English DT Article ID HEINZ BODY FORMATION; OXIDATIVE REACTIONS; FISCHER-344 RATS; ORAL TOXICITY; HEMOGLOBIN; TRINITROTOLUENE; OXYHEMOGLOBIN; ERYTHROCYTES; ACETYLPHENYLHYDRAZINE; DENATURATION AB We studied the hematological effects of single and repealed exposure to 1,3,5-trinitrobenzene (TNB) in rats. Male F-344 rats were gavaged with TNB al 35.5 and 71 mg/kg in corn oil. Blood was collected 5 h and 24 h after a single oral dose or 24 h after daily oral doses for 4 or 10 d in four different set of experiments. A dose-dependent methemoglobinemia was present only in blood collected 5 h after a single dose. A highly significant dose-dependent anemia with reduced red cells, hemoglobin, and hemotocrit was present in rats receiving TNB for 4 or 10 d. A dose-dependent decrease in serum triglycerides was present in rats receiving TNB for 10 d. There was no hemolysis when rat erythrocytes were incubated with TNB (in vitro) for 9 h. Spectral changes of hemoglobin recorded during the incubation with TNB confirm methemoglobin formation and progressive denaturation of hemoglobin-forming hemichromes. The significance of methemoglobin and hemichrome formation is discussed, and a probable hypothesis for the hemolytic anemia is suggested. C1 OKLAHOMA STATE UNIV,COLL VET MED,DEPT VET PATHOL,STILLWATER,OK 74078. USA,CTR HLTH PROMOT & PREVENT MED,FREDERICK,MD. NR 47 TC 8 Z9 8 U1 0 U2 2 PU TAYLOR & FRANCIS PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 0098-4108 J9 J TOXICOL ENV HEALTH JI J. Toxicol. Environ. Health PD SEP PY 1995 VL 46 IS 1 BP 57 EP 72 PG 16 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA RU782 UT WOS:A1995RU78200006 PM 7666494 ER PT J AU SHANDERA, KC THOMPSON, IM AF SHANDERA, KC THOMPSON, IM TI INTRAPERITONEAL URINARY EXTRAVASATION ASSOCIATED WITH INFECTED URACHAL CYST SO JOURNAL OF UROLOGY LA English DT Note DE BLADDER; URACHAL CYST AB Urachal disorders in the adult are distinctly uncommon with most series comprising fewer than 5 cases. Nevertheless, on rare occasions infected urachal cysts or sinuses may be the cause of acute abdominal symptoms. A rare case of necrosis of the bladder dome, intraperitoneal urinary extravasation and peritonitis due to an infected urachal cyst is reported. RP SHANDERA, KC (reprint author), BROOKE ARMY MED CTR,UROL SERV,SAN ANTONIO,TX, USA. NR 3 TC 1 Z9 1 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD SEP PY 1995 VL 154 IS 3 BP 1130 EP 1131 DI 10.1016/S0022-5347(01)66998-2 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA RN531 UT WOS:A1995RN53100064 PM 7637063 ER PT J AU GARCIN, D LEZZI, M DOBBS, M ELLIOTT, RM SCHMALJOHN, C KANG, CY KOLAKOFSKY, D AF GARCIN, D LEZZI, M DOBBS, M ELLIOTT, RM SCHMALJOHN, C KANG, CY KOLAKOFSKY, D TI THE 5'-ENDS OF HANTAAN VIRUS (BUNYAVIRIDAE) RNAS SUGGEST A PRIME-AND-REALIGN MECHANISM FOR THE INITIATION OF RNA-SYNTHESIS SO JOURNAL OF VIROLOGY LA English DT Article ID MESSENGER-RNAS; NUCLEOTIDE-SEQUENCE; HETEROGENEOUS SEQUENCES; TRANSCRIPTION PROCESSES; GENOME REPLICATION; NONTEMPLATED BASES; ESCHERICHIA-COLI; UUKUNIEMI VIRUS; CODING STRATEGY; VACCINIA VIRUS AB We examined the 5' ends of Hantaan virus (HTN) genomes and mRNAs to gain insight into the manner in which these chains were initiated. Like those of all members of the family Bunyaviridae described so far, the HTN mRNAs contained 5' terminal extensions that were heterogeneous in both length and sequence, presumably because HTN also ''cap snatches'' host mRNAs to initiate the viral mRNAs. Unexpectedly however, almost ah of the mRNAs contained a G residue at position -1, and a large fraction also lacked precisely one of the three UAG repeats at the termini. The genomes, on the other hand, commenced with a U residue at position +1, but only 5' monophosphates were found here, indicating that these chains may not have initiated with UTP at this position. Taken together, these unusual findings suggest a prime-and-realign mechanism of chain initiation in which mRNAs are initiated with a G-terminated host cell primer and genomes with GTP, not at the 3' end of the genome template but internally (opposite the template C at position +3), and after extension by one or a few nucleotides, the nascent chain realigns backwards by virtue of the terminal sequence repeats, before processive elongation takes place. For genome initiation, an endonuclease, perhaps that involved in cap snatching, is postulated to remove the 5' terminal extension of the genome, leaving the 5' pU at position +1. C1 UNIV GENEVA,SCH MED,CTR MED UNIV,DEPT GENET & MICROBIOL,CH-1211 GENEVA,SWITZERLAND. UNIV OTTAWA,FAC MED,DEPT MICROBIOL & IMMUNOL,OTTAWA,ON K1H 8M5,CANADA. UNIV GLASGOW,INST VIROL,GLASGOW G11 5JR,LANARK,SCOTLAND. USA,MED RES INST INFECT DIS,DIV VIROL,FT DETRICK,MD 21701. UNIV WESTERN ONTARIO,FAC MED,DEPT MICROBIOL & IMMUNOL,LONDON,ON N6A 5B7,CANADA. NR 66 TC 122 Z9 126 U1 1 U2 8 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD SEP PY 1995 VL 69 IS 9 BP 5754 EP 5762 PG 9 WC Virology SC Virology GA RN986 UT WOS:A1995RN98600065 PM 7637020 ER PT J AU Ferrando, RE Schuschereba, ST Quong, JA Bowman, PD AF Ferrando, RE Schuschereba, ST Quong, JA Bowman, PD TI Carbon dioxide laser induction of heat shock protein 70 synthesis: Comparison with high temperature treatment SO LASERS IN MEDICAL SCIENCE LA English DT Article DE heat shock protein 70 (hsp70); carbon dioxide laser; sodium arsenite; human diploid fibroblast; electrophoresis; immunocytochemistry ID STRESS PROTEINS AB In a previous study, it was demonstrated that heat shock protein 70 (hsp70) was induced by short duration (<1 s) carbon dioxide (CO2) laser radiation (10.6 mu m). To further characterize the stress response after laser irradiation, the time course of synthesis and cellular localization of hsp70 has been followed. As it had been shown that laser irradiation elevated the temperature to about 67 +/- 2 degrees C, the authors also attempted to duplicate the response with high temperature elevation by dipping cells grown on plastic coverslips into media heated in a hot water bath to specified temperatures. Exposure to CO2 laser irradiation resulted in a time course and localization response similar to that reported for induction of hsp70 by elevated temperature (41-44 degrees C). However, in contrast to the response to elevated temperature, only hsp70 was induced by laser irradiation. Short exposure (1-4 s) of cells medium heated to 58 degrees C produced a response similar to that obtained with CO2 laser irradiation suggesting that the CO2 laser irradiation effect on cells is produced by heating for short periods to 55-70 degrees C. C1 USA,MED RES DETACHMENT,WALTER REED ARMY INST RES,BROOKS AFB,SAN ANTONIO,TX 78285. NR 15 TC 6 Z9 7 U1 0 U2 0 PU W B SAUNDERS CO LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0268-8921 J9 LASER MED SCI JI Lasers Med. Sci. PD SEP PY 1995 VL 10 IS 3 BP 207 EP 212 DI 10.1007/BF02133333 PG 6 WC Engineering, Biomedical; Surgery SC Engineering; Surgery GA UJ058 UT WOS:A1995UJ05800009 ER PT J AU PROSSER, WH JACKSON, KE KELLAS, S SMITH, BT MCKEON, J FRIEDMAN, A AF PROSSER, WH JACKSON, KE KELLAS, S SMITH, BT MCKEON, J FRIEDMAN, A TI ADVANCED WAVE-FORM-BASED ACOUSTIC-EMISSION DETECTION OF MATRIX CRACKING IN COMPOSITES SO MATERIALS EVALUATION LA English DT Article DE ACOUSTIC EMISSION; COMPOSITE MATERIALS; CRACKS; GRAPHITE-EPOXY COMPOSITES; NONDESTRUCTIVE EVALUATION; TRANSVERSE MATRIX CRACKING ID TRANSVERSE CRACKING; EPOXY; STRENGTH; GLASS; WAVES AB An advanced, waveform based acoustic emission system was used to study the initiation of transverse matrix cracking in cross-ply graphite/epoxy composites. The acoustic emission signals were detected with broad band, high fidelity sensors, and digitized for analysis. Plate wave propagation analysis was used to discriminate noise signals from those generated by cracks. The noise signals were confirmed to have originated in the specimen grip region by a new, highly accurate form of location analysis which was independent of threshold setting. Six different specimen thicknesses ([0(n), 90(n), 0(n)],n = 1 to 6) were tested under stroke controlled, quasi-static tensile loading. The presence and location of the cracks were confirmed post test by microscopy. Back scatter ultrasonics, penetrant enhanced X-ray techniques, and in limited cases, destructive sectioning and microscopy were also used to determine the length of the cracks. For thicker specimens (n > 2), there was an exact, one to one correspondence between acoustic emission crack signals and observed cracks. The lengths of the cracks in these specimens extended the full specimen width. Precise linear location of the crack position was demonstrated. The average absolute value of the difference between the microscopy determined crack location and the acoustic emission crack location was 3.2 mm (0.225 in.) for a nominal sensor gage length of 152 mm (6 in.). A four-sensor array was used that improved the linear location accuracy and provided the lateral position of the crack initiation site. This allowed determination of whether the cracks initiated in the interior bulk of the specimens or along the free edges. For all cracks, the location of the crack initiation site was at one of the edges of the specimen. The cracks were more difficult to detect with acoustic emission in the thin specimens (n less than or equal to 2). The cracks in these specimens also initiated at the specimen edge, but did not immediately propagate across the specimen width. They generated significantly smaller amplitude acoustic emission signals. These measurements demonstrated that the same source mechanism can generate a wide range of acoustic emission signal amplitudes. C1 NASA, LANGLEY RES CTR, LOCKHEED ENGN & SCI CO, HAMPTON, VA 23681 USA. COLL WILLIAM & MARY, WILLIAMSBURG, VA 23187 USA. RP PROSSER, WH (reprint author), USA, NASA, LANGLEY RES CTR, MS 231, HAMPTON, VA 23681 USA. NR 37 TC 114 Z9 117 U1 1 U2 19 PU AMER SOC NON-DESTRUCTIVE TEST PI COLUMBUS PA 1711 ARLINGATE LANE PO BOX 28518, COLUMBUS, OH 43228-0518 SN 0025-5327 J9 MATER EVAL JI Mater. Eval. PD SEP PY 1995 VL 53 IS 9 BP 1052 EP 1058 PG 7 WC Materials Science, Characterization & Testing SC Materials Science GA RT981 UT WOS:A1995RT98100010 ER PT J AU AYYAGARI, MS KAMTEKAR, S PANDE, R MARX, KA KUMAR, J TRIPATHY, SK KAPLAN, DL AF AYYAGARI, MS KAMTEKAR, S PANDE, R MARX, KA KUMAR, J TRIPATHY, SK KAPLAN, DL TI BIOSENSORS FOR PESTICIDE DETECTION BASED ON ALKALINE PHOSPHATASE-CATALYZED CHEMILUMINESCENCE SO MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC MATERIALS SENSORS AND SYSTEMS LA English DT Article; Proceedings Paper CT International Conference on Intelligent Materials (ICIM2) CY 1994 CL WILLIAMSBURG, VA DE ORGANOPHOSPHORUS PESTICIDES; BIOSENSORS; PESTICIDE DETECTION; ALKALINE PHOSPHATASE; CHEMILUMINESCENCE ID FRUITS AB An enzyme-based detection methodology for sensing and quantitation of organophosphorus pesticides is described. The enzyme, alkaline phosphatase, is used in soluble form for reactions in bulk solutions, and in immobilized form for reactions on optical fibers or in glass capillaries. The immobilization strategy involves building a molecular assembly of the enzyme and a conjugated copolymer, poly(3-undecylthiophene-co-3-thiophenecarboxyldehyde-biotin-LC-hydrozone) on a glass surface. Hydrophobic or specific biotin-streptavidin interactions are used to immobilize the biotinylated copolymer on a silanized glass surface and attach a streptavidin conjugate of alkaline phosphatase to the copolymer. Alkaline phosphatase catalyzes the dephosphorylation of a macrocyclic compound, chloro-3-(4-methoxy spiro[1,2 dioxetane-3-2'-tricyclo-{3.3.1.1}-decan]-4-yl) phenyl phosphate and releases light; the chemiluminescence signal is detected with a simple photomultiplier tube. The enzyme activity, and proportionately the chemiluminescence signal strength, are inhibited in the presence of organophosphorus pesticides such as paraoxon. Quantitation of pesticides is thus possible from the inverse correlation between the enzyme activity or signal strength and pesticide concentration. Detection of paraoxon at a concentration of about 50 ppb is achieved with this system. Reaction kinetics are examined for the enzyme in both states. The immobilized enzyme can be reused a number of times, and there is no significant loss of enzyme activity over a period of eight weeks. The design of a flow cell for continuous analysis of the pesticides is described. C1 UNIV MASSACHUSETTS,CTR ADV MAT & INTELLIGENT BIOMAT,DEPT CHEM,LOWELL,MA 01854. USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. UNIV MASSACHUSETTS,CTR ADV MAT & INTELLIGENT BIOMAT,DEPT PHYS,LOWELL,MA 01854. NR 15 TC 20 Z9 24 U1 3 U2 7 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0928-4931 J9 MAT SCI ENG C-BIOMIM JI Mater. Sci. Eng. C-Biomimetic Mater. Sens. Syst. PD SEP PY 1995 VL 2 IS 4 BP 191 EP 196 DI 10.1016/0928-4931(95)00077-1 PG 6 WC Materials Science, Multidisciplinary SC Materials Science GA TG131 UT WOS:A1995TG13100002 ER PT J AU WILKERSON, RC HRIBAR, LJ MILSTREY, EG FALERO, GC AF WILKERSON, RC HRIBAR, LJ MILSTREY, EG FALERO, GC TI THE IDENTIFICATION OF ANOPHELES (NYSSORHYNCHUS) RONDONI (DIPTERA, CULICIDAE) IN MATO-GROSSO STATE, BRAZIL - AN ANALYSIS OF KEY CHARACTER VARIABILITY SO MEMORIAS DO INSTITUTO OSWALDO CRUZ LA English DT Article DE ANOPHELES (NYSSORHYNCHUS) RONDONI; KEY CHARACTERS; IDENTIFICATION; PUPA ID MOSQUITOS AB A morphological study was made of a population of Anopheles (Nyssorhynchus) rondoni (Neiva and Pinto) from northern Mate Grosso, Brazil. This population usually lacked the primary key character of a dark basal band on hindtarsomere 3, i.e., hindtarsomere 3 was all white as in most other members of the subgenus. It was determined that this species can be recognized instead by the presence of a dark spot on the thorax made up of a large dark prescutellar space that is contiguous with a concolorous central area on the scutellum. A secondary character of a dark area on the costa created by the fusion of the humeral dark, presector dark and sector dark proximal spots is also usually reliable. Regression analyses comparing the lengths and ratios of the dark bands on hindtarsomeres 2 to those on 3 describe a straight line relationship. This suggests that the ''atypical'' population is at one end of a character gradient. We propose that in the subgenus Nyssorhynchus individuals that have a long basal band on hindtarsomere 2 are more likely to also have a basal band on hindtarsomere 3. The pupal stage of this species has not been previously described Reared-associated specimens ft om this study show that the pupa can be easily differentiated from all other Nyssorhynchus by the relatively stout, usually 2 or 3 branched (1-5), setae 1 and 5 on segments IV-VII. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. FLORIDA MED ENTOMOL LAB,VERO BEACH,FL 32962. PAN AMER HLTH ORG,BRASILIA,DF,BRAZIL. NR 21 TC 4 Z9 4 U1 0 U2 1 PU MEM INST OSWALDO CRUZ PI RIO DE JANEIRO PA SECRETARY CAIXA POSTAL 926, 20001 RIO DE JANEIRO, RJ, BRAZIL SN 0074-0276 J9 MEM I OSWALDO CRUZ JI Mem. Inst. Oswaldo Cruz PD SEP-OCT PY 1995 VL 90 IS 5 BP 575 EP 582 PG 8 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA RY153 UT WOS:A1995RY15300006 ER PT J AU KECSKES, LJ HALL, IW AF KECSKES, LJ HALL, IW TI HOT EXPLOSIVE CONSOLIDATION OF W-TI ALLOYS SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article AB High-density (98 pct TD) 95W-5Ti (wt pct) alloys have been fabricated by a combustion-synthesis-assisted hot explosive consolidation (CSA-HEC) technique. In the current procedure, a W + Ti powder compact is preheated by the heat released by a Ti + C exothermic combustion synthesis reaction and subsequently consolidated by pressure waves generated by the detonation of an explosive. The amounts of explosive charge, sample configuration, and molar ratio of exothermic material to sample were found to affect the degree of consolidation. Auxiliary temperature measurements were performed to determine the precompaction thermal history of the sample to obtain the optimum delay time for consolidation. As observed with scanning electron microscopy (SEM), the CSA-HEC microcomposites consist of W particles surrounded by a partially discontinuous Ti-rich matrix. Transmission electron microscopy (TEM) was also used to further characterize the W/Ti interfacial region. The pertinent features of the technique as well as those of the product microstructures are discussed. C1 UNIV DELAWARE,MAT SCI PROGRAM,NEWARK,DE 19716. RP KECSKES, LJ (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. RI Kecskes, Laszlo/F-6880-2014 OI Kecskes, Laszlo/0000-0002-1342-3729 NR 26 TC 13 Z9 13 U1 0 U2 1 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 420 COMMONWEALTH DR, WARRENDALE, PA 15086 SN 1073-5623 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD SEP PY 1995 VL 26 IS 9 BP 2407 EP 2414 DI 10.1007/BF02671254 PG 8 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA RR270 UT WOS:A1995RR27000020 ER PT J AU HARVEY, RP DUNBAR, NW MCINTOSH, WC ESSER, RP TAYLOR, S AF HARVEY, RP DUNBAR, NW MCINTOSH, WC ESSER, RP TAYLOR, S TI A METEORITIC EVENT LAYER IN ANTARCTIC ICE SO METEORITICS LA English DT Meeting Abstract C1 CASE WESTERN RESERVE UNIV,CLEVELAND,OH 44106. NEW MEXICO INST MIN & TECHNOL,SONOMA,NM 87801. COLD REG RES & ENGN LAB,HANOVER,NH 03755. NR 3 TC 1 Z9 1 U1 0 U2 1 PU METEORITICAL SOC PI FAYETTEVILLE PA DEPT CHEMISTRY/BIOCHEMISTRY, UNIV ARKANSAS, FAYETTEVILLE, AR 72701 SN 0026-1114 J9 METEORITICS JI Meteoritics PD SEP PY 1995 VL 30 IS 5 BP 517 EP 518 PG 2 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA RR518 UT WOS:A1995RR51800080 ER PT J AU McGillin, HO AF McGillin, HO TI Article 31(b) triggers: Re-examining the ''officiality doctrine'' SO MILITARY LAW REVIEW LA English DT Article RP McGillin, HO (reprint author), USA,JUDGE ADVOCATE GEN SCH,ACAD DEPT,CHARLOTTESVILLE,VA 22901, USA. NR 21 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1995 VL 150 BP 1 EP 78 PG 78 WC Law SC Government & Law GA VA043 UT WOS:A1995VA04300001 ER PT J AU Masterton, RP AF Masterton, RP TI The military's drunk driving statute: Have we gone too far? SO MILITARY LAW REVIEW LA English DT Article ID BREATH-ALCOHOL ANALYSIS; BLOOD-ALCOHOL; WISCONSIN DRIVERS; PERFORMANCE RP Masterton, RP (reprint author), USA,JUDGE ADVOCATE GEN SCH,CRIMINAL LAW DEP,CHARLOTTESVILLE,VA 22901, USA. NR 22 TC 0 Z9 0 U1 0 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1995 VL 150 BP 353 EP 381 PG 29 WC Law SC Government & Law GA VA043 UT WOS:A1995VA04300005 ER PT J AU Berrigan, ED AF Berrigan, ED TI Which side are you on? Trying to be for labor when it's flat on its back - Geoghegan,T SO MILITARY LAW REVIEW LA English DT Book Review RP Berrigan, ED (reprint author), USA,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1995 VL 150 BP 397 EP 402 PG 6 WC Law SC Government & Law GA VA043 UT WOS:A1995VA04300007 ER PT J AU Cook, HOG AF Cook, HOG TI The myth of repressed memory: False memories and allegations of sexual abuse - Loftus,E, Ketcham,K SO MILITARY LAW REVIEW LA English DT Book Review RP Cook, HOG (reprint author), USA,JUDGE ADVOCATE GEN SCH,CHARLOTTESVILLE,VA, USA. NR 16 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1995 VL 150 BP 403 EP 409 PG 7 WC Law SC Government & Law GA VA043 UT WOS:A1995VA04300008 ER PT J AU Lescault, MA AF Lescault, MA TI Crusade in Europe - Eisenhower,DD SO MILITARY LAW REVIEW LA English DT Book Review RP Lescault, MA (reprint author), USA,JUDGE ADVOCATE GEN SCH,ADM & CIVIL LAW DEPT,CHARLOTTESVILLE,VA, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1995 VL 150 BP 423 EP 429 PG 7 WC Law SC Government & Law GA VA043 UT WOS:A1995VA04300011 ER PT J AU Shumake, S AF Shumake, S TI The class of 1846, from West Point to Appomattox: Stonewall Jackson, George McClellan and their brothers - Waugh,JC SO MILITARY LAW REVIEW LA English DT Book Review RP Shumake, S (reprint author), USA,JUDGE ADVOCATE GEN CORPS,CHARLOTTESVILLE,VA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1995 VL 150 BP 434 EP 439 PG 6 WC Law SC Government & Law GA VA043 UT WOS:A1995VA04300013 ER PT J AU Hawk, TO AF Hawk, TO TI Robert E. Lee: A biography - Thomas,EM, Lee,RE SO MILITARY LAW REVIEW LA English DT Book Review RP Hawk, TO (reprint author), USA,JUDGE ADVOCATE GEN CORPS,CHARLOTTESVILLE,VA, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1995 VL 150 BP 440 EP 443 PG 4 WC Law SC Government & Law GA VA043 UT WOS:A1995VA04300014 ER PT J AU Hawk, SD AF Hawk, SD TI Shrouds of glory - Groom,W SO MILITARY LAW REVIEW LA English DT Book Review RP Hawk, SD (reprint author), USA,JUDGE ADVOCATE GEN CORPS,CHARLOTTESVILLE,VA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1995 VL 150 BP 444 EP 448 PG 5 WC Law SC Government & Law GA VA043 UT WOS:A1995VA04300015 ER PT J AU Parker, CA AF Parker, CA TI In their own words, Civil War commanders - Stiles,TJ SO MILITARY LAW REVIEW LA English DT Book Review RP Parker, CA (reprint author), USA,JUDGE ADVOCATE GEN CORPS,CHARLOTTESVILLE,VA, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1995 VL 150 BP 449 EP 454 PG 6 WC Law SC Government & Law GA VA043 UT WOS:A1995VA04300016 ER PT J AU Jones, KD AF Jones, KD TI Strength for the fight - A history of Black Americans in the military - Nalty,BC SO MILITARY LAW REVIEW LA English DT Book Review RP Jones, KD (reprint author), USA,JUDGE ADVOCATE GEN CORPS,CHARLOTTESVILLE,VA, USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1995 VL 150 BP 455 EP 458 PG 4 WC Law SC Government & Law GA VA043 UT WOS:A1995VA04300017 ER PT J AU Burch, L AF Burch, L TI The ashes of Waco: An investigation - Reavis,DJ SO MILITARY LAW REVIEW LA English DT Book Review RP Burch, L (reprint author), USA,JUDGE ADVOCATE GEN CORPS,CHARLOTTESVILLE,VA, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1995 VL 150 BP 459 EP 464 PG 6 WC Law SC Government & Law GA VA043 UT WOS:A1995VA04300018 ER PT J AU Wells, EG AF Wells, EG TI Hiroshima in America: Fifty years of denial - Lifton,RJ, Mitchell,G SO MILITARY LAW REVIEW LA English DT Book Review RP Wells, EG (reprint author), USA,JUDGE ADVOCATE GEN CORPS,CHARLOTTESVILLE,VA, USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1995 VL 150 BP 465 EP 470 PG 6 WC Law SC Government & Law GA VA043 UT WOS:A1995VA04300019 ER PT J AU WARBER, J HADDAD, E HODGKIN, G LEE, J AF WARBER, J HADDAD, E HODGKIN, G LEE, J TI DIETARY FIBER CONTENT OF A 6-DAY WEIGHED MILITARY RATION SO MILITARY MEDICINE LA English DT Article AB No studies have accurately reported on the total dietary fiber content of current military dining facility meals. The military nutrition data base is incomplete for total, insoluble, and soluble dietary fiber content. The Military Recommended Dietary Allowances has no recommendation for dietary fiber. The American Dietetic Association advises all Americans to consume 25 to 35 g/day. This study estimated total dietary fiber intake from a calculated analysis of a 6-day weighed military ration. The calculated fiber values for the sample military diet provided 6.8 g of total dietary fiber per 1,000 kcal. Substituting whole-grain cereal products for all the refined cereal products increased the fiber to 9.5 g/1,000 kcal. Calculated results were validated by chemical analysis. Total dietary fiber was 4.1 g/1,000 kcal for the sample military diet and 5.6 g/1,000 kcal for the whole-grain test diet. Fiber content of the sample military diet was well below recommended levels but similar to that found in other studies on the typical American diet. RP WARBER, J (reprint author), USA,INST ENVIRONM MED,DIV MIL NUTR,NATICK,MA 01760, USA. NR 0 TC 0 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 1995 VL 160 IS 9 BP 438 EP 442 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA RU744 UT WOS:A1995RU74400004 PM 7478026 ER PT J AU WATANABE, HR JENSEN, PS ROSEN, LN NEWBY, J RICHTERS, JE CORTES, RM AF WATANABE, HR JENSEN, PS ROSEN, LN NEWBY, J RICHTERS, JE CORTES, RM TI SOLDIER FUNCTIONING UNDER CHRONIC STRESS - EFFECTS OF FAMILY MEMBER ILLNESS SO MILITARY MEDICINE LA English DT Article AB The psychological functioning of soldiers with a handicapped. child in the family were compared with that of soldiers without such a child through a survey of 443 soldiers. Self-report questionnaires were utilized to measure depressive symptoms, marital adjustment, social. supports, stressful life events. military satisfaction, military performance, and coping. Differences between the 147 soldier-parents with a handicapped child and those without were examined using one-way analyses of variance. The results indicated that soldier-parents with a handicapped child showed significantly higher depressive symptoms, including lower scores on coping, less favorable perception of their military skills and abilities, and more pessimistic attitudes about their long-term military career options, than did the comparison group. Differences in marital satisfaction were not found. Also, perceived social sup ports played a significantly greater role in buffering the effects of stress on marital adjustment among families with a handicapped child than among those without. RP WATANABE, HR (reprint author), WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,DIV NEUROPSYCHIAT,WASHINGTON,DC 20005, USA. OI Richters, John/0000-0002-6780-1828; Jensen, Peter/0000-0003-2387-0650 NR 0 TC 7 Z9 7 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 1995 VL 160 IS 9 BP 457 EP 461 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA RU744 UT WOS:A1995RU74400009 PM 7478031 ER PT J AU CHANG, SM LILLISHEARNE, PK LARSON, DA WARA, WM BOLLEN, AW PRADOS, MD AF CHANG, SM LILLISHEARNE, PK LARSON, DA WARA, WM BOLLEN, AW PRADOS, MD TI PINEALOBLASTOMA IN ADULTS SO NEUROSURGERY LA English DT Article DE BRAIN NEOPLASM; CHEMOTHERAPY; MEDULLOBLASTOMA; PINEALOBLASTOMA; RADIATION THERAPY ID PRIMITIVE NEUROECTODERMAL TUMORS; PINEAL REGION TUMORS; CHILDREN AB THIS IS THE first report of a series of adults (>16 years of age) with pineoblastomas who had their entire neuraxis staged at the time of diagnosis. Between 1975 and 1992, seven men and four women with histologically proven pineoblastomas were evaluated at the University of California, San Francisco. The median age at diagnosis was 36 years (range, 17-59 yr). All patients presented with symptomatic hydrocephalus. One patient had a complete surgical resection, eight had subtotal resections, and two had biopsies only. One patient refused any treatment or follow-up review and died 6 months after diagnosis. The five patients with positively staged disease had progression either focally or in the spine 8 to 49 months (median, 10 mo) after initial diagnosis and died 1 to 20 months after recurrence; the median overall survival time from the date of surgery was 30 months. In contrast, all five patients with negatively staged disease were alive without disease progression after a median of 26 months of follow-up. Our retrospective review shows that the extent of disease at diagnosis seems to be an important prognostic factor for pineoblastomas, as is true for medulloblastomas and other primitive neuroectodermal tumors. Initial staging should include examination of the cerebrospinal fluid and magnetic resonance imaging of the spine. Although patients with pineoblastomas are often treated with adjuvant systemic chemotherapy after craniospinal irradiation, the benefits of this approach are unclear. C1 UNIV CALIF SAN FRANCISCO,SCH MED,DEPT NEUROL SURG,BRAIN TUMOR RES CTR,NEUROONCOL SERV,SAN FRANCISCO,CA 94143. UNIV CALIF SAN FRANCISCO,SCH MED,DEPT RADIAT ONCOL,SAN FRANCISCO,CA 94143. UNIV CALIF SAN FRANCISCO,SCH MED,DEPT PATHOL,SAN FRANCISCO,CA 94143. BROOKE ARMY MED CTR,DEPT RADIAT ONCOL,FT SAM HOUSTON,TX. FU NCI NIH HHS [CA-13525] NR 20 TC 48 Z9 51 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0148-396X J9 NEUROSURGERY JI Neurosurgery PD SEP PY 1995 VL 37 IS 3 BP 383 EP 390 PG 8 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA RU161 UT WOS:A1995RU16100006 PM 7501100 ER PT J AU Yoder, LH AF Yoder, LH TI Staff nurses' career development relationships and self-reports of professionalism, job satisfaction, and intent to stay SO NURSING RESEARCH LA English DT Article ID ROLE MODELS; TURNOVER; EMPLOYEES; MENTORS AB The purpose of this study was to investigate the range of career development relationships (CDRs) experienced by staff nurses in relation to the outcomes of professionalism, job satisfaction and intent to stay. A sample of 390 Army staff nurses completed questionnaires measuring five CDRs - precepting, peer-strategizing, coaching, sponsoring, and mentoring - and the outcome variables. Findings indicated that 61% of the sample experienced a CDR, with the predominant CDR being coaching. No CDR affected professionalism; however, job satisfaction and intent to stay may warrant further investigation in relation to CDRs. The findings suggest that if nurses perceived that an interest was taken in their career development and felt valued by the developer, then usually staff nurses viewed the relationship as professionally important. This perception of importance often influenced intent to stay in a positive direction. RP Yoder, LH (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 39 TC 46 Z9 51 U1 0 U2 11 PU AMER J NURSING CO PI NEW YORK PA 555 W 57TH ST, NEW YORK, NY 10019-2961 SN 0029-6562 J9 NURS RES JI Nurs. Res. PD SEP-OCT PY 1995 VL 44 IS 5 BP 290 EP 297 PG 8 WC Nursing SC Nursing GA UA164 UT WOS:A1995UA16400006 PM 7567485 ER PT J AU ARANDA, FJ RAO, DVGLN WONG, CL ZHOU, P CHEN, ZP AKKARA, JA KAPLAN, DL ROACH, JF AF ARANDA, FJ RAO, DVGLN WONG, CL ZHOU, P CHEN, ZP AKKARA, JA KAPLAN, DL ROACH, JF TI NONLINEAR-OPTICAL INTERACTIONS IN BACTERIORHODOPSIN USING Z-SCAN (VOL 2, PG 204, 1995) SO OPTICAL REVIEW LA English DT Correction, Addition C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. RP ARANDA, FJ (reprint author), UNIV MASSACHUSETTS,DEPT PHYS,BOSTON,MA 02125, USA. RI Rao, Devulapalli/L-8863-2015 NR 1 TC 0 Z9 0 U1 0 U2 0 PU OPTICAL SOC JAPAN PI TOKYO PA KUDAN-KITA BLDG 5F, 1-12-3, KUDAN-KITA CHIYODA-KU, TOKYO 102, JAPAN SN 1340-6000 J9 OPT REV JI Opt. Rev. PD SEP-OCT PY 1995 VL 2 IS 5 BP U3 EP U3 PG 1 WC Optics SC Optics GA TG517 UT WOS:A1995TG51700014 ER PT J AU THOMAS, TL AF THOMAS, TL TI FAULT LINES AND FACTIONS IN THE RUSSIAN ARMY SO ORBIS-A JOURNAL OF WORLD AFFAIRS LA English DT Article RP THOMAS, TL (reprint author), FOREIGN MIL STUDIES OFF,FT LEAVENWORTH,KS, USA. NR 46 TC 0 Z9 0 U1 0 U2 0 PU JAI PRESS INC PI GREENWICH PA 55 OLD POST RD-#2, PO BOX 1678, GREENWICH, CT 06836-1678 SN 0030-4387 J9 ORBIS-J WORLD AFF JI Orbis-J. World Aff. PD FAL PY 1995 VL 39 IS 4 BP 531 EP 548 DI 10.1016/0030-4387(95)90008-X PG 18 WC International Relations SC International Relations GA RW560 UT WOS:A1995RW56000009 ER PT J AU SARAIVA, EMB PIMENTA, PFP BRODIN, TN ROWTON, E MODI, GB SACKS, DL AF SARAIVA, EMB PIMENTA, PFP BRODIN, TN ROWTON, E MODI, GB SACKS, DL TI CHANGES IN LIPOPHOSPHOGLYCAN AND GENE-EXPRESSION ASSOCIATED WITH THE DEVELOPMENT OF LEISHMANIA-MAJOR IN PHLEBOTOMUS-PAPATASI SO PARASITOLOGY LA English DT Article DE LEISHMANIA; SAND FLY; METACYCLIC; LIPOPHOSPHOGLYCAN ID SURFACE LIPOPHOSPHOGLYCAN; PROMASTIGOTES; STAGE; METACYCLOGENESIS; TRANSMISSION; PSYCHODIDAE; DIPTERA AB Stage-specific molecular and morphogenic markers were used to follow the kinetics of appearance, number, and position of metacyclic promastigotes developing during the course of L. major infection in a natural vector, Phlebotomzrs papatasi. Expression of surface lipophosphoglycan (LPG) on transformed promastigotes was delayed until the appearance of nectomonad forms on day 3, and continued to be abundantly expressed by all promastigotes thereafter. An epitope associate with arabinose substitution of LPG side-chain oligosaccharides, identified by its differential expression by metacyclics in vitro, was detected on the surface of a low proportion of midgut promastigotes beginning on day 5, and on up to 60% of promatigotes on days 10 and 15. In contrast 100% of the parasites egested from the mouthparts during forced feeding of 15 day infected flies stained strongly for this epitope. At each time-point, the surface expression of the modified LPG was restricted to morphologically distinguished metacyclic forms. Ultrastructural study of the metacyclic surface revealed an approximate 2-fold increase in the thickness of the surface coat compared to nectomonad forms, suggesting elongation of LPG as occurs during metacyclogenesis in vitro. A metacyclic-associated transcript (MAT-1), another marker identified by its differential expression in vitro, also showed selective expression by promastigotes in the fly, and was used in in situ hybridization studies to demonstrate the positioning of metacyclics in the anterior gut. C1 NIAID,PARASIT DIS LAB,BETHESDA,MD 20892. WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. RI Rowton, Edgar/A-4474-2012; Rowton, Edgar/A-1975-2011 OI Rowton, Edgar/0000-0002-1979-1485 NR 26 TC 56 Z9 57 U1 0 U2 1 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 40 WEST 20TH STREET, NEW YORK, NY 10011-4211 SN 0031-1820 J9 PARASITOLOGY JI Parasitology PD SEP PY 1995 VL 111 BP 275 EP 287 PN 3 PG 13 WC Parasitology SC Parasitology GA RV202 UT WOS:A1995RV20200004 PM 7567096 ER PT J AU LOW, K BARKER, AJ VINCENT, JM AF LOW, K BARKER, AJ VINCENT, JM TI A 13-YEAR-OLD WITH A PAINFUL, SWOLLEN FOOT AND EOSINOPHILIA SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Note C1 TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. RP LOW, K (reprint author), TRIPLER ARMY MED CTR,DEPT FAMILY PRACTICE,HONOLULU,HI 96859, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD SEP PY 1995 VL 14 IS 9 BP 820 EP 820 PG 1 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA RU932 UT WOS:A1995RU93200023 PM 8559642 ER PT J AU MARINKOVICH, GA PICHOFF, BE IWAMOTO, LM DRESSEL, MVC NAKAMURA, KT AF MARINKOVICH, GA PICHOFF, BE IWAMOTO, LM DRESSEL, MVC NAKAMURA, KT TI ACUTE HYPEROXIC INJURY ATTENUATES THE RELAXING EFFECTS OF LOOP DIURETICS AND SALBUTAMOL ON LARGE AIRWAYS OF NEWBORN GUINEA-PIGS SO PEDIATRIC RESEARCH LA English DT Article ID SMOOTH-MUSCLE; BRONCHOPULMONARY DYSPLASIA; ETHACRYNIC-ACID; INDUCED BRONCHOCONSTRICTION; INHALED FUROSEMIDE; CONTROLLED TRIAL; OXYGEN-TOXICITY; LUNG-DISEASE; PULMONARY; INFANTS AB We have previously found an age-dependent relaxing effect of furosemide in normal fetal, newborn, and adult guinea pig airways with fetal trachea exhibiting the greatest relaxation and adult tissue the least. This study was designed to expand upon this finding by determining if in vivo hyperoxic exposure would influence in vitro airway relaxation mediated by the loop diuretics, furosemide and ethacrynic acid, and the beta(2)-adrenoceptor agonist, salbutamol. Newborn guinea pigs were raised in >95% FiO(2) until ill; controls,in room air. Isometric relaxation to 3 X 10(-5) M furosemide, 3 X 10(-6) M ethacrynic acid, or 10(-8)-10(-6) M salbutamol was recorded in 3 X 10(-6) M histamine-constricted airway rings. Ethacrynic acid, like furosemide, relaxed newborn guinea pig airways. Hyperoxia did not alter the contractile effect of 3 X 10(-6) M histamine but did significantly decrease the relaxing effect of furosemide, ethacrynic acid, and salbutamol, Loop diuretic mediated airway relaxation was accentuated in HEPES buffer when compared with Krebs, whereas salbutamol-mediated relaxation was unaffected. These results suggest that hyperoxia nonspecifically decreases airway responsiveness to the relaxing agents studied. C1 KAPIOLANI MED CTR WOMEN & CHILDREN,JOHN A BURNS SCH MED,DEPT PEDIAT,HONOLULU,HI 96826. TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. FU NHLBI NIH HHS [HL-45220] NR 33 TC 5 Z9 5 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD SEP PY 1995 VL 38 IS 3 BP 280 EP 285 DI 10.1203/00006450-199509000-00002 PG 6 WC Pediatrics SC Pediatrics GA RP608 UT WOS:A1995RP60800002 PM 7494647 ER PT J AU CROSLAND, RD AF CROSLAND, RD TI ACTION OF REACTIVE OXYGEN SPECIES AND THEIR ANTAGONISTS ON TWITCH TENSION OF THE RAT PHRENIC NERVE-DIAPHRAGM SO PHARMACOLOGY & TOXICOLOGY LA English DT Article ID FREE-RADICAL SCAVENGERS; AMYOTROPHIC-LATERAL-SCLEROSIS; SKELETAL-MUSCLE; REPERFUSION INJURY; ARACHIDONIC-ACID; SUPEROXIDE-DISMUTASE; FATIGUE; INDUCTION AB Reactive oxygen species have been implicated in normal and pathological processes of many tissues, including skeletal muscle. I extended previous studies by examining the effect of these intermediates and eight of their antagonists (superoxide dismutase, catalase, deferoxamine, [Cu(II)](2)(3,5-diisopropylsalicylate)(4), 1,2-dimethyl-3-hydroxy-pyridone, 1,3-dimethyl-2-thiourea, N-(2-mercaptopropionyl)-glycine, vitamin E) on indirectly stimulated twitch tension of an in vitro neuroskeletomuscular preparation, the phrenic nerve-diaphragm of the rat. In the absence of exogenous reactive oxygen species, none of the antagonists potentiated twitch tension, and all but one (N-[2-mercaptopropionyl]-glycine) of the membrane-permeant antagonists attenuated twitch tension. The reactive oxygen intermediate-generating system of purine plus xanthine oxidase reduced indirectly stimulated twitch tension by 36% while having no effect on directly stimulated twitch tension. Catalase (but not superoxide dismutase or deferoxamine) eliminated the reduction in twitch tension, indicating that hydrogen peroxide played a role in the reduction. The membrane-permeant antagonists [Cu(II)](2)(3,5-diisopropylsalicylate)(4) and 1,2-'dimethyl-3-hydroxy-pyridone also eliminated the reduction in twitch tension caused by reactive oxygen species, suggesting that hydrogen peroxide could have acted intracellularly through an iron-catalyzed Haber-Weiss reaction to produce hydroxyl radical, which in turn reacted with intracellular components, thereby reducing twitch tension. RP USA, MED RES INST INFECT DIS, DIV TOXICOL, FREDERICK, MD 21702 USA. NR 30 TC 6 Z9 6 U1 0 U2 0 PU BLACKWELL MUNKSGAARD PI FREDERIKSBERG C PA 1 ROSENORNS ALLE, DK-1970 FREDERIKSBERG C, DENMARK SN 0901-9928 J9 PHARMACOL TOXICOL JI Pharmacol. Toxicol. PD SEP PY 1995 VL 77 IS 3 BP 231 EP 237 PG 7 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA RU595 UT WOS:A1995RU59500013 PM 8884889 ER PT J AU SARAMA, S AF SARAMA, S TI FEWER EPITHETS, PLEASE SO PHOTONICS SPECTRA LA English DT Letter RP SARAMA, S (reprint author), ARMY RES LAB,ADELPHI,MD, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LAURIN PUBL CO INC PI PITTSFIELD PA BERKSHIRE COMMON PO BOX 1146, PITTSFIELD, MA 01202 SN 0731-1230 J9 PHOTON SPECTRA JI Photon. Spect. PD SEP PY 1995 VL 29 IS 9 BP 12 EP 12 PG 1 WC Optics SC Optics GA RT984 UT WOS:A1995RT98400004 ER PT J AU STEARNS, HF AF STEARNS, HF TI POWELL PAMPERED SO POLICY REVIEW LA English DT Letter RP STEARNS, HF (reprint author), USA,SPACE & STRATEG DEF COMMAND,HUNTSVILLE,AL, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU HERITAGE FOUNDATION PI WASHINGTON PA 214 MASSACHUSETTS AVE NE, WASHINGTON, DC 20002 SN 0146-5945 J9 POLICY REV JI Policy Rev. PD FAL PY 1995 IS 74 BP 96 EP 96 PG 1 WC Political Science SC Government & Law GA RY295 UT WOS:A1995RY29500025 ER PT J AU JENSEN, DW AF JENSEN, DW TI NILPOTENCY OF DERIVATIONS IN PRIME-RINGS SO PROCEEDINGS OF THE AMERICAN MATHEMATICAL SOCIETY LA English DT Article DE DERIVATIONS; NILPOTENCY; PRIME RINGS AB In 1957, E. C. Posner proved that if lambda and delta are derivations of a prime ring R, characteristic R not equivalent to 2, then lambda delta = 0 implies either lambda = 0 or delta = 0. We extend this well-known result by showing that, without any characteristic restriction, lambda delta(m) = 0 implies either lambda = 0 or delta(4m-1) = 0. We also prove that lambda(n) delta = 0 implies either delta(2) = 0 or lambda(12n-9) = 0. In the case where lambda(n) delta(m) = 0, we show that if lambda and delta commute, then at least one of the derivations must be nilpotent. RP JENSEN, DW (reprint author), US MIL ACAD,DEPT MATH STAT,W POINT,NY 10996, USA. NR 3 TC 4 Z9 4 U1 0 U2 0 PU AMER MATHEMATICAL SOC PI PROVIDENCE PA 201 CHARLES ST, PROVIDENCE, RI 02940-2213 SN 0002-9939 J9 P AM MATH SOC JI Proc. Amer. Math. Soc. PD SEP PY 1995 VL 123 IS 9 BP 2633 EP 2636 DI 10.2307/2160554 PG 4 WC Mathematics, Applied; Mathematics SC Mathematics GA RT074 UT WOS:A1995RT07400005 ER PT J AU WESENSTEN, NJ BALKIN, TJ DAVIS, HQ BELENKY, GL AF WESENSTEN, NJ BALKIN, TJ DAVIS, HQ BELENKY, GL TI REVERSAL OF TRIAZOLAM-INDUCED AND ZOLPIDEM-INDUCED MEMORY IMPAIRMENT BY FLUMAZENIL SO PSYCHOPHARMACOLOGY LA English DT Article DE FLUMAZENIL; TRIAZOLAM; ZOLPIDEM; MEMORY; BENZODIAZEPINE ANTAGONIST ID BENZODIAZEPINE ANTAGONIST RO-15-1788; RO 15-1788; INDUCED AMNESIA; MIDAZOLAM; PHARMACOKINETICS; PSYCHOMOTOR; RECEPTORS; DIAZEPAM; SEDATION; LIGANDS AB The effects of flumazenil, a benzodiazepine receptor antagonist, on triazolam- and zolpidem-induced memory impairment were investigated. Sixty subjects received oral triazolam 0.5 mg, zolpidem 20.0 mg, or placebo at 10 a.m. (n = 20 per drug). Ninety minutes later, half of the subjects (n = 10) in each oral drug group were administered flumazenil 1.0 mg, while the remaining half received placebo (normal saline), through indwelling venous catheters. Learning/memory tests (including Simulated Escape, Restricted Reminding, Paired-Associates, and Repeated Acquisition) were administered at that time, and at 1.5-h intervals over the next 6 h. Triazolam/placebo and zolpidem/placebo drug combinations impaired memory on all tests (all Ps < 0.05). However, the triazolam/flumazenil and zolpidem/flumazenil groups showed no evidence of impairment during any test session. These results demonstrate that flumazenil 1.0 mg rapidly and lastingly reverses memory impairment caused by agonists of the benzodiazepine receptor. Furthermore, nonsignificant trends suggested that performance of the placebo/flumazenil group was consistently better than that of the placebo/placebo group, denoting a possible role of endogenous benzodiazepine agonists in natural sleep/wake processes. RP WESENSTEN, NJ (reprint author), WALTER REED ARMY INST RES,DEPT BEHAV BIOL,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307, USA. NR 46 TC 19 Z9 19 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0033-3158 J9 PSYCHOPHARMACOLOGY JI Psychopharmacology PD SEP PY 1995 VL 121 IS 2 BP 242 EP 249 DI 10.1007/BF02245635 PG 8 WC Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA RY288 UT WOS:A1995RY28800013 PM 8545530 ER PT J AU WILLINGHAM, WF AF WILLINGHAM, WF TI THE NEED FOR HISTORICAL RESEARCH ON THE UNITED-STATES-ARMY-CORPS-OF-ENGINEERS PROTECTION OF THE SALMON SO PUBLIC HISTORIAN LA English DT Article RP WILLINGHAM, WF (reprint author), USA CORPS ENGINEERS,PORTLAND,OR, USA. NR 8 TC 1 Z9 1 U1 0 U2 0 PU UNIV CALIF PRESS PI BERKELEY PA JOURNALS DEPT 2120 BERKELEY WAY, BERKELEY, CA 94720 SN 0272-3433 J9 PUBL HISTORIAN JI Public Hist. PD FAL PY 1995 VL 17 IS 4 BP 9 EP 16 PG 8 WC History SC History GA TM877 UT WOS:A1995TM87700003 ER PT J AU PANTONGRAGBROWN, L NELSON, AM BROWN, AE BUETOW, PC BUCK, JL AF PANTONGRAGBROWN, L NELSON, AM BROWN, AE BUETOW, PC BUCK, JL TI FROM THE ARCHIVES OF THE AFIP - GASTROINTESTINAL MANIFESTATIONS OF ACQUIRED-IMMUNODEFICIENCY-SYNDROME - RADIOLOGIC-PATHOLOGICAL CORRELATION SO RADIOGRAPHICS LA English DT Review ID IMMUNE-DEFICIENCY-SYNDROME; PNEUMOCYSTIS-CARINII INFECTION; MYCOBACTERIUM-AVIUM-INTRACELLULARE; ABDOMINAL CT FINDINGS; CYTOMEGALO-VIRUS ESOPHAGITIS; TINY ECHOGENIC FOCI; DISSEMINATED HISTOPLASMOSIS; RADIOGRAPHIC FINDINGS; KAPOSIS-SARCOMA; HOMOSEXUAL MEN AB Gastrointestinal diseases are common in patients with the acquired immunodeficiency syndrome (AIDS), In this review, the radiologic and pathologic findings of these diseases in AIDS patients are illustrated with cases from the archives of the Armed Forces Institute of Pathology, Diseases are categorized in two etiologic groups, opportunistic infections and AIDS-related neoplasms, Opportunistic infections include those caused by viral, fungal, protozoan, and bacterial pathogens, The AIDS-related neoplasms of primary importance are Kaposi sarcoma and non-Hodgkin lymphoma. The radiologic findings of these gastrointestinal diseases are frequently nonspecific, However, interpretation of the images with knowledge of the underlying pathologic entities and the level of compromise of the immune system helps narrow the differential diagnosis and often helps identify the presumptive diagnosis. C1 ARMED FORCES INST PATHOL,DEPT INFECT & PARASIT DIS PATHOL,DIV AIDS PATHOL,WASHINGTON,DC 20306. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL & NUCL MED,BETHESDA,MD 20814. WALTER REED ARMY INST RES,DEPT DIAGNOST RETROVIROL,ROCKVILLE,MD. RP PANTONGRAGBROWN, L (reprint author), ARMED FORCES INST PATHOL,DEPT RADIOL PATHOL,BLDG 54,ALASKA & FERN STS,WASHINGTON,DC 20306, USA. NR 105 TC 14 Z9 14 U1 0 U2 0 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0271-5333 J9 RADIOGRAPHICS JI Radiographics PD SEP PY 1995 VL 15 IS 5 BP 1155 EP 1178 PG 24 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA RV156 UT WOS:A1995RV15600013 PM 7501857 ER PT J AU KNAPIK, JJ REYNOLDS, KL DUPLANTIS, KL JONES, BH AF KNAPIK, JJ REYNOLDS, KL DUPLANTIS, KL JONES, BH TI FRICTION BLISTERS - PATHOPHYSIOLOGY, PREVENTION AND TREATMENT SO SPORTS MEDICINE LA English DT Review AB Blisters occur frequently, especially in vigorously active populations. Studies using repetitive rubbing techniques show that blisters result from frictional forces that mechanically separate epidermal cells at the level of the stratum spinosum. Hydrostatic pressure causes the area of the separation to fill with a fluid that is similar in composition to plasma but has a lower protein level. About 6 hours after formation of the blister, cells in the blister base begin to take up amino acids and nucleosides; at 24 hours, there is high mitotic activity in the basal cells; at 48 and 120 hours, new stratum granulosum and stratum corneum, respectively, can be seen. The magnitude of frictional forces (F-f) and the number of times that an object cycles across the skin determine the probability of blister development - the higher the F-f, the fewer the cycles necessary to produce a blister. Moist skin increases F-f, but very dry or very wet skin decreases F-f. Blisters are more likely in skin areas that have a thick horny layer held tightly to underlying structures (e.g. palms of the hands or soles of the feet). More vigorous activity and the carrying of heavy loads during locomotion both appear to increase the likelihood of foot blisters. Antiperspirants with emollients and drying powders applied to the foot do not appear to decrease the probability of friction blisters. There is some evidence that foot blister incidence can be reduced by closed cell neoprene insoles. Wearing foot socks composed of acrylic results in fewer foot blisters in runners. A thin polyester sock, combined with a thick wool or polypropylene sock that maintains its bulk when exposed to sweat and compression, reduces blister incidence in Marine recruits. Recent exposure of the skin to repeated low intensity F-f results in a number of adaptations including cellular proliferation and epidermal thickening, which may reduce the likelihood of blisters. More well-designed studies are necessary to determine which prevention strategies actually decrease blister probability. Clinical experience suggests draining intact blisters and maintaining the blister roof results in the least patient discomfort and may reduce the possibility of secondary infection. Treating deroofed blisters with hydrocolloid dressings provides pain relief and may allow patients to continue physical activity if necessary. There is no evidence that antibiotics influence blister healing. Clinical trials are needed to determine the efficacy of various blister treatment methods. Considering the pervasive nature of friction blisters, there is a substantial amount of basic and applied research that remains to be performed, especially in the areas of prevention and treatment. C1 USA,ENVIRONM MED RES INST,DIV OCCUPAT MED,NATICK,MA 01760. STOUGH MED ASSOC,HOT SPRINGS,AR. USA,CTR HLTH PROMOT & PREVENT MED,DIRECTORATE EPIDEMIOL & DIS SURVEILLANCE,ABERDEEN PROVING GROUND,MD. RP KNAPIK, JJ (reprint author), USA,RES LAB,HUMAN RES & ENGN DIRECTORATE,DIV SOLDIER PERFORMANCE,ABERDEEN PROVING GROUND,MD 21005, USA. NR 0 TC 54 Z9 56 U1 1 U2 12 PU ADIS INTERNATIONAL LTD PI AUCKLAND PA 41 CENTORIAN DR, PRIVATE BAG 65901, MAIRANGI BAY, AUCKLAND 10, NEW ZEALAND SN 0112-1642 J9 SPORTS MED JI Sports Med. PD SEP PY 1995 VL 20 IS 3 BP 136 EP 147 DI 10.2165/00007256-199520030-00002 PG 12 WC Sport Sciences SC Sport Sciences GA RV352 UT WOS:A1995RV35200002 PM 8570998 ER PT J AU MULLER, HE FANNING, GH BRENNER, DJ AF MULLER, HE FANNING, GH BRENNER, DJ TI ISOLATION OF SERRATIA-FONTICOLA FROM MOLLUSKS SO SYSTEMATIC AND APPLIED MICROBIOLOGY LA English DT Article DE SERRATIA FONTICOLA; PHENOTYPIC IDENTIFICATION; DNA HYBRIDIZATION; TAXONOMY; MOLLUSKS; ECOLOGIC NICHE ID SPECIMENS AB Eleven of some 2400 strains of gram-negative rods isolated from mollusks were identified as Serratia fonticola both biochemically and by DNA hybridization. The phenotypic and genotypic data confirm that S. fonticola belongs to the genus Serratia. C1 WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC. CTR DIS CONTROL & PREVENT,NATL CTR INFECT DIS,EMERGING BACTERIAL & MYCOT DIS BRANCH,ATLANTA,GA 30341. RP MULLER, HE (reprint author), STAATLICHES MED UNTERSUCHUNGSAMT,ALTER RAUTHEIMER WEG 16,D-38126 BRAUNSCHWEIG,GERMANY. NR 16 TC 5 Z9 5 U1 1 U2 1 PU GUSTAV FISCHER VERLAG PI STUTTGART PA WOLLGRASWEG 49 POSTFACH 72 01 43, D-70577 STUTTGART, GERMANY SN 0723-2020 J9 SYST APPL MICROBIOL JI Syst. Appl. Microbiol. PD SEP PY 1995 VL 18 IS 2 BP 279 EP 284 PG 6 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA RV995 UT WOS:A1995RV99500014 ER PT J AU RIVERA, VR POLI, MA BIGNAMI, GS AF RIVERA, VR POLI, MA BIGNAMI, GS TI PROPHYLAXIS AND TREATMENT WITH A MONOCLONAL-ANTIBODY OF TETRODOTOXIN POISONING IN MICE SO TOXICON LA English DT Article ID SAXITOXIN; ASSAY; ANHYDROTETRODOTOXIN; PROTECTION AB The ability of a tetrodotoxin (TTX)-specific monoclonal antibody to confer passive protection against lethal TTX challenge was investigated. The monoclonal antibody, T20G10, has an estimated affinity for TTX of approximately 10(-9) M and is about 50-fold less reactive with anhydrotetrodotoxin and unreactive with tetrodonic acid by competitive immunoassay. T20G10 specifically inhibited TTX binding in an in vitro radioligand receptor binding assay, but had no effect on the binding of saxitoxin to the sodium channel on rat brain membranes. In prophylaxis studies, mice were administered T20G10 via the tail vein 30 min prior to i.p. TTX challenge (10 mu g/kg). Under these conditions, 100 mu g T20G10 protected 6/6 mice, whereas 3/6 mice were protected with 50 mu g T20G10. Non-specific control monoclonal antibody did not protect against lethality. Therapy studies simulating oral intoxication were performed with mice given a lethal dose of TTX by gavage in a suspension of non-fat dry milk in phosphate-buffered saline. Death occurred within 25-35 min in 6/6 mice not treated with T20G10. However, 500 mu g T20G10 administered via the tail vein 10-15 min after oral TTX exposure prevented death in 6/6 mice. Lower doses of mAb conferred less protection. C1 HAWAII BIOTECHNOL GRP INC,AIEA,HI 96701. USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702. NR 23 TC 25 Z9 27 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD SEP PY 1995 VL 33 IS 9 BP 1231 EP 1237 DI 10.1016/0041-0101(95)00060-Y PG 7 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA RW056 UT WOS:A1995RW05600013 PM 8585093 ER PT J AU Perez, D Dominici, GO Hierro, B Otte, D AF Perez, D Dominici, GO Hierro, B Otte, D TI New grasshopper genera and species from the Dominican Republic (Hispaniola) (Acridoidea: Acrididae) SO TRANSACTIONS OF THE AMERICAN ENTOMOLOGICAL SOCIETY LA English DT Article AB The Hispaniolan fauna of Acridoid grasshoppers is highly endemic and much more diverse than previously recognized. Three new genera and seven new species of Acridoid grasshoppers are here described and illustrated, mainly from subtropical dry forest populations in southwestern Dominican Republic, West Indies. The affinities of these new genera to other neotropical grasshoppers are unclear. They seem to be representatives of a ''primitive'' grasshopper fauna indigenous to the Caribbean. RP Perez, D (reprint author), USA,VIRAL CARCINOGENESIS LAB,BLDG 560,RM 11-84,FREDERICK,MD 21702, USA. NR 6 TC 4 Z9 6 U1 0 U2 0 PU AMER ENTOMOL SOC PI PHILADELPHIA PA 1900 BENJ FRANKLIN PARKWAY, PHILADELPHIA, PA 19103-1195 SN 0002-8320 J9 T AM ENTOMOL SOC JI Trans. Am. Entomol. Soc. PD SEP PY 1995 VL 121 IS 3 BP 153 EP 171 PG 19 WC Entomology SC Entomology GA TT456 UT WOS:A1995TT45600002 ER EF