FN Thomson Reuters Web of Science™ VR 1.0 PT J AU RUSHING, E ARMONDA, R ANSARI, Q MENA, H AF RUSHING, E ARMONDA, R ANSARI, Q MENA, H TI MESENCHYMAL CHONDROSARCOMA - A CLINICOPATHOLOGICAL AND FLOW CYTOMETRIC STUDY OF 13 CASES PRESENTING IN THE CENTRAL-NERVOUS-SYSTEM SO JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY LA English DT Meeting Abstract C1 UNIV TEXAS,SW MED CTR,DEPT PATHOL,NEUROPATHOL LAB,DALLAS,TX. UNIV TEXAS,SW MED CTR,DEPT PATHOL,FLOW CYTOMETRY LAB,DALLAS,TX. ARMED FORCES INST PATHOL,DEPT NEUROPATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,DEPT NEUROSURG,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSN NEUROPATHOLOGISTS INC PI LAWRENCE PA 1041 NEW HAMPSHIRE ST, LAWRENCE, KS 66044 SN 0022-3069 J9 J NEUROPATH EXP NEUR JI J. Neuropathol. Exp. Neurol. PD MAY PY 1995 VL 54 IS 3 BP 457 EP 457 DI 10.1097/00005072-199505000-00199 PG 1 WC Clinical Neurology; Neurosciences; Pathology SC Neurosciences & Neurology; Pathology GA QX385 UT WOS:A1995QX38500198 ER PT J AU ATKINSON, JC ROYCE, LS WELLNER, R PILLEMER, SR BERMUDEZ, D FOX, PC AF ATKINSON, JC ROYCE, LS WELLNER, R PILLEMER, SR BERMUDEZ, D FOX, PC TI ANTISALIVARY ANTIBODIES IN PRIMARY SJOGRENS-SYNDROME SO JOURNAL OF ORAL PATHOLOGY & MEDICINE LA English DT Article DE AUTOANTIBODIES; SALIVARY GLANDS; SJOGRENS SYNDROME; SS-A/RO; SS-B/LA ID CELL-LINE; SS-A; GLAND; LA; FEATURES; PROTEINS; PARTICLE; RNA AB Earlier studies have described an antibody that recognized salivary ductal epithelium in sera from 15-50% of patients with primary Sjogren's syndrome; however, the specific salivary antigen in those studies was not identified The present study further investigated this unknown salivary antigen. Twenty-nine of 31 patients (94%) with primary Sjogren's syndrome demonstrated IgG antinuclear antibodies that bound to an epithelial cell line with ductal characteristics derived from a human salivary gland. Seventy-seven percent of these patients had serum antibodies that bound to ductal cells of normal human parotid tissue after formalin fixation. Western blots of cell extracts, immunofluorescence, and adsorption studies indicated that SS-A/Ro and SS-B/La were the antigens recognized in the salivary cell line. The pattern of fluorescence seen when anti-SS-B/La bound to normal parotid tissue was identical to the fluorescence pattern of the anti-salivary ductal antibodies described in earlier literature. C1 NIDR,CLIN INVEST SECT,CLIN INVEST & PATIENT CARE BRANCH,BETHESDA,MD 20892. USA,MED RES INST INFECT DIS,DIV PATHOPHYSIOL,FT DETRICK,MD 21702. NIAMSD,OFF PREVENT EPIDEMIOL & CLIN APPLICAT,BETHESDA,MD 20892. NR 25 TC 11 Z9 11 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0904-2512 J9 J ORAL PATHOL MED JI J. Oral Pathol. Med. PD MAY PY 1995 VL 24 IS 5 BP 206 EP 212 DI 10.1111/j.1600-0714.1995.tb01168.x PG 7 WC Dentistry, Oral Surgery & Medicine; Pathology SC Dentistry, Oral Surgery & Medicine; Pathology GA QX631 UT WOS:A1995QX63100004 PM 7616459 ER PT J AU TAYLOR, BF WARING, CA BRASHEAR, TA AF TAYLOR, BF WARING, CA BRASHEAR, TA TI THE EFFECTS OF THERAPEUTIC APPLICATION OF HEAT OR COLD FOLLOWED BY STATIC STRETCH ON HAMSTRING MUSCLE LENGTH SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE HAMSTRING MUSCLES; STRETCHING; THERMAL AB Hamstring stretching is an important part of treatment programs aimed at decreasing the likelihood of hamstring injury. Few studies have examined the use of superficial thermal modalities in conjunction with hamstring stretching. The purpose of this study was to determine if the application of a superficial heating or cooling modality, followed by static stretch, increased the efficacy of static stretching of the hamstring muscles. This study examined 12 male and 12 female subjects, ages 18-38. All subjects received each of the following treatments: heat followed by static stretch, cold followed by static stretch, and static stretch alone. Each treatment was separated by at least 1 week. Pre- and post-treatment measurement of hamstring length were obtained using the Active-Knee-Extension (AKE) test. The data were analyzed via a 2 X 3 analysis of variance experimental design. Results indicated that there was an increase in hamstring length regardless of stretch treatment used, with F(1,23) = 35.49, p < .001. However, no significant differences were detected among stretch treatments, F < 1.0, nor among interaction effects, F < 1.0. The results of this study suggest that adequate hamstring stretching can occur without the use of a superficial thermal modality. C1 USA,FT KNOX,KY. USA,FT SILL,OK. NR 0 TC 39 Z9 40 U1 3 U2 3 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD MAY PY 1995 VL 21 IS 5 BP 283 EP 286 PG 4 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA QU282 UT WOS:A1995QU28200006 PM 7787852 ER PT J AU SLANE, S SALOMON, M AF SLANE, S SALOMON, M TI COMPOSITE GEL ELECTROLYTE FOR RECHARGEABLE LITHIUM BATTERIES SO JOURNAL OF POWER SOURCES LA English DT Article DE RECHARGEABLE LITHIUM BATTERIES; POLYMER ELECTROLYTES ID POLYMER ELECTROLYTES; IONIC-CONDUCTIVITY AB Composite polymer electrolyte films consisting of zeolite powders dispersed in poly(acrylonitrile) (PAN)-based gels with LiAsF6 have been prepared and their electrochemical properties studied. Gel electrolytes prepared by adding LiAsF6 in propylene carbonate (PC) and ethylene carbonate (EC) mixtures with PAN have demonstrated ionic conductivities greater than 10(-3) S/cm at room temperature and above. The addition of zeolite powders increased ionic conductivity at low temperatures due to the highly amorphous nature of the composite him. Impedance spectroscopy was performed to study the Li electrode/electrolyte interface and a reduction of the passivation kinetics was observed. Cyclic voltammetry showed that addition of PAN and zeolite powder to LiAsF6, PC and EC mixtures did not change the stable electrochemical potential window. In Li/LiCoO2 cells, at 25 degrees C, these composite electrolytes demonstrated current densities as high as 0.5 mA/cm(2), with little voltage or capacity loss compared with cells with liquid electrolytes. RP SLANE, S (reprint author), USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,DIV POWER SOURCES,AMSRL EP PB,FT MONMOUTH,NJ 07703, USA. NR 12 TC 70 Z9 79 U1 9 U2 40 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD MAY PY 1995 VL 55 IS 1 BP 7 EP 10 DI 10.1016/0378-7753(94)02148-V PG 4 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA RD341 UT WOS:A1995RD34100002 ER PT J AU PEDERSEN, AM FULTON, SK PORTER, L FRANCIS, GL AF PEDERSEN, AM FULTON, SK PORTER, L FRANCIS, GL TI TUMORNECROSIS FACTOR-ALPHA AFFECTS IN-VITRO HORMONE PRODUCTION BY JEG-3 CHORIOCARCINOMA CELL-CULTURES SO JOURNAL OF REPRODUCTIVE IMMUNOLOGY LA English DT Article DE CYTOKINE; TNF-ALPHA; PLACENTA; LABOR; STEROID HORMONES ID TUMOR-NECROSIS-FACTOR; PRETERM LABOR; AMNIOTIC-FLUID; INTRAAMNIOTIC INFECTION; HUMAN PARTURITION; LEYDIG-CELLS; INTERLEUKIN-6; PROSTAGLANDINS; SECRETION; RAT AB Steroid hormones, produced by the placenta, appear to be critically important in maintaining the pregnancy of experimental animals and possibly humans. Previous studies in our laboratory have shown that macrophage-conditioned media, which are known to contain several cytokines including tumor necrosis factor-alpha (TNF-alpha), decreased the in vitro synthesis of progesterone (P) and increased the synthesis of estradiol (E(2)) by placental fragments. The present study was designed to further our understanding of the effect of cytokines on the synthesis of placental trophoblast hormones. The current study shows that TNF-alpha (1-20 ng/ml) decreases the in vitro synthesis of P and increases the synthesis of both E(2) and human chorionic gonadotropin (hCG) by JEG-3 choriocarcinoma cells (a model for trophoblast hormone synthesis). The effects of TNF-alpha are independent of changes in formation of adenosine 3':5' cyclic-monophosphate, guanosine 3':5' cyclic-monophosphate, prostaglandin E2, and prostaglandin F2 alpha. However, the effect of TNF-alpha on P formation is blocked by cycloheximide (1 mu g/ml). These observations suggest TNF-alpha could have effects on placental hormone synthesis which might be important in the pathogenesis of both normal and preterm labor. At least some of these effects appear mediated through new protein synthesis. C1 WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT,BETHESDA,MD 20814. UNIV PORTLAND,PORTLAND,OR 97203. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 32 TC 22 Z9 22 U1 0 U2 0 PU ELSEVIER SCI PUBL IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0165-0378 J9 J REPROD IMMUNOL JI J. Reprod. Immunol. PD MAY PY 1995 VL 29 IS 1 BP 69 EP 80 DI 10.1016/0165-0378(95)00931-A PG 12 WC Immunology; Reproductive Biology SC Immunology; Reproductive Biology GA RN342 UT WOS:A1995RN34200006 PM 8531193 ER PT J AU APODACA, CC GILILLAND, JL AF APODACA, CC GILILLAND, JL TI SUCCESSFUL REPEAT MICROSURGICAL FALLOPIAN-TUBE ANASTOMOSIS - A CASE-REPORT SO JOURNAL OF REPRODUCTIVE MEDICINE LA English DT Article DE STERILIZATION REVERSAL ID STERILIZATION; REVERSAL AB While multiple series have documented the success of microsurgical tubal anastomosis, there is limited information available concerning repeat procedures; that may reflect reluctance on the part of the microsurgeon to consider these patients candidates for additional surgery. In this report we describe a patient who underwent repeat microsurgical fallopian tube anastomosis and subsequently achieved pregnancy. C1 TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,REPROD ENDOCRINE & INFERTIL SECT,HONOLULU,HI 96859. NR 10 TC 0 Z9 0 U1 0 U2 0 PU SCI PRINTERS & PUBL INC PI ST LOUIS PA P.O. DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 SN 0024-7758 J9 J REPROD MED JI J. Reprod. Med. PD MAY PY 1995 VL 40 IS 5 BP 407 EP 408 PG 2 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA QY127 UT WOS:A1995QY12700019 PM 7608888 ER PT J AU REARDON, C AF REARDON, C TI GETTYSBURG - CULPS-HILL AND CEMETERY-HILL - PFANZ,HW SO JOURNAL OF SOUTHERN HISTORY LA English DT Book Review RP REARDON, C (reprint author), USA,INST MIL HIST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOUTHERN HISTORICAL ASSN PI ATHENS PA UNIV GEORGIA HISTORY DEPT, ATHENS, GA 30602 SN 0022-4642 J9 J SOUTHERN HIST JI J. South. Hist. PD MAY PY 1995 VL 61 IS 2 BP 394 EP 395 DI 10.2307/2211611 PG 2 WC History SC History GA QX874 UT WOS:A1995QX87400038 ER PT J AU GOFF, JM MOLLOY, M DEBBAS, MT HALE, DA JAQUES, DP AF GOFF, JM MOLLOY, M DEBBAS, MT HALE, DA JAQUES, DP TI LONG-TERM IMPACT OF PREVIOUS BREAST BIOPSY ON BREAST-CANCER SCREENING MODALITIES SO JOURNAL OF SURGICAL ONCOLOGY LA English DT Article DE MAMMOGRAPHY; BREAST EXAMINATION; POSTOPERATIVE ID NEEDLE LOCALIZATION BIOPSY; MAMMOGRAPHY; REDUCTION; MORTALITY; AGE AB Approximately 80% of breast biopsies are performed for what proves to be a benign process. The patients who undergo these procedures should continue screening with breast physical examination and mammography. The long-term impact of breast biopsy on these screening modalities has not been well studied. We performed a prospective, follow-up evaluation in 63 patients who underwent needle localization biopsy with benign histology at our institution between 6 and 7 years ago. This evaluation consisted of a directed history, breast physical examination, and follow-up mammogram. Two patients (3%) had undergone mastectomy for an interval breast cancer; 17 others (28%) had undergone subsequent biopsies. No patient had changes on physical examination of the biopsy site. All mammograms were evaluated as normal or as having benign abnormalities. Excisional breast biopsy does not generally produce long-term changes affecting the interpretation of breast physical examination or mammography. (C) 1995 Wiley-Liss, Inc. C1 WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. NR 10 TC 1 Z9 1 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0022-4790 J9 J SURG ONCOL JI J. Surg. Oncol. PD MAY PY 1995 VL 59 IS 1 BP 18 EP 20 DI 10.1002/jso.2930590106 PG 3 WC Oncology; Surgery SC Oncology; Surgery GA QY857 UT WOS:A1995QY85700006 PM 7745971 ER PT J AU SKELTON, HG SMITH, KJ LASKIN, WB MCCARTHY, WF GAGNIER, JM GRAHAM, JH LUPTON, GP AF SKELTON, HG SMITH, KJ LASKIN, WB MCCARTHY, WF GAGNIER, JM GRAHAM, JH LUPTON, GP TI DESMOPLASTIC MALIGNANT-MELANOMA SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID NEUROTROPIC MELANOMA; PROGNOSTIC FACTORS; VARIANT; CELL AB Background: Desmoplastic malignant melanoma (DMM) is an uncommon variant of malignant melanoma and often is difficult to diagnose. Because of the relative rarity of this tumor, it has not been well studied and controversy remains concerning its biologic potential. Objective: We compared survival rates of DMM with those of other malignant melanomas and determined what clinical and/or histologic features, if any, correlated with survival. Methods: The files of the Armed Forces Institute of Pathology were searched for cases of DMM or related tumors with adequate material for further histologic and immunohistochemical evaluation. Follow-up on each patient was requested from the pathologist, clinician, and/or the patient. The follow-up was correlated with the histologic findings in each case. The relationship of histologic features to disease-free survival was evaluated. Results: Adequate material for evaluation was available in 128 cases. The overall histologic features were similar to those previously reported. Immunohistochemical studies showed that all lesions were negative for HMB-45, a marker for premelanosomes. Factors that correlated with survival included tumor location, sex, tumor depth, and the presence of stromal mucin. The 5-year disease-free survival rate was 68% for all cases and 61% for lesions more than 4 mm deep. Conclusion: With a 5-year disease-free survival rate of 61%, DMM has a significantly better prognosis than other melanomas that have a 5-year disease-free survival rates of 40% to 41%. This may be related to neural differentiation of these tumors. C1 USA,RES LOGIST & ACQUIST COMMAND,BETHESDA,MD. US HLTH SCI MED SCH,DEPT ANAT PATHOL,BETHESDA,MD. USN HOSP,DEPT SURG,BETHESDA,MD. SCRIPPS CLIN & RES FDN,DEPT PATHOL,DIV DERMATOPATHOL,LA JOLLA,CA. RP SKELTON, HG (reprint author), ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306, USA. NR 31 TC 105 Z9 106 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD MAY PY 1995 VL 32 IS 5 BP 717 EP 725 DI 10.1016/0190-9622(95)91448-X PN 1 PG 9 WC Dermatology SC Dermatology GA QW104 UT WOS:A1995QW10400004 PM 7722014 ER PT J AU MYHAND, RC HUNG, PH CALDWELL, JB JAMES, WD SAU, P HARGIS, JB AF MYHAND, RC HUNG, PH CALDWELL, JB JAMES, WD SAU, P HARGIS, JB TI OSTEOGENIC-SARCOMA WITH SKIN METASTASES SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Note ID OSTEOSARCOMA; BONE C1 WALTER REED ARMY MED CTR,HEMATOL ONCOL SERV,WASHINGTON,DC. PENTAGON HLTH CLIN,ARLINGTON,VA. WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC. NR 20 TC 17 Z9 18 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD MAY PY 1995 VL 32 IS 5 BP 803 EP 805 DI 10.1016/0190-9622(95)91479-X PN 1 PG 3 WC Dermatology SC Dermatology GA QW104 UT WOS:A1995QW10400018 PM 7722027 ER PT J AU CUOZZO, DW BENSON, PM SPERLING, LC SKELTON, HG AF CUOZZO, DW BENSON, PM SPERLING, LC SKELTON, HG TI ESSENTIAL SYPHILITIC ALOPECIA REVISITED SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Note ID SECONDARY SYPHILIS; ADULTS AB There has been a resurgence of syphilis in the past decade. Uncommonly, diffuse hair loss, termed essential alopecia, is the only sign of syphilitic infection. We describe two patients with syphilis in whom the first sign of disease was alopecia and discuss the clinical and histopathologic findings of essential syphilitic alopecia. C1 ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306. RP CUOZZO, DW (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 15 TC 23 Z9 24 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD MAY PY 1995 VL 32 IS 5 BP 840 EP 843 PN 2 PG 4 WC Dermatology SC Dermatology GA QW359 UT WOS:A1995QW35900003 PM 7722040 ER PT J AU KIM, HH SOHN, KS CASAS, LM PFEFFER, RL LAREAU, RT AF KIM, HH SOHN, KS CASAS, LM PFEFFER, RL LAREAU, RT TI PREPARATION OF PARAELECTRIC PLT THIN-FILMS USING REACTIVE MAGNETRON SPUTTERING OF MULTICOMPONENT METAL TARGET SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID PBTIO3 AB Paraelectric lead lanthanum titanate (PLT) thin films have been prepared by a reactive de magnetron sputtering system using a multicomponent metal target. The surface area control of each element on the target markedly facilitates the fabrication of thin films of complex ceramic compounds. A postdeposition heat-treatment was applied to all as-deposited PLT thin films at annealing temperatures up to 750 degrees C for crystallization. The composition of the PLT (28) thin film annealed at 650 degrees C was: Pb, 0.73; La, 0.28; Ti, 0.88; O, 2.9. The dielectric constant and dissipation factor of the thin film (200 nm) at low field measurements (500 V cm(-1)) are 1216 and 0.018, respectively. The charge storage density using a typical Sawyer-Tower circuit with a 500 Hz sine wave was 12.5 mu C cm(-2) at the electric field of 200 kV cm(-1). C1 USA,RES LAB,FT MONMOUTH,NJ 07703. RP KIM, HH (reprint author), NEW JERSEY INST TECHNOL,DEPT ELECT & COMP ENGN,NEWARK,NJ 07102, USA. NR 13 TC 0 Z9 0 U1 0 U2 0 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD MAY PY 1995 VL 142 IS 5 BP 1640 EP 1643 DI 10.1149/1.2048629 PG 4 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA QX765 UT WOS:A1995QX76500051 ER PT J AU YOWELL, L CONNON, WH AF YOWELL, L CONNON, WH TI ON-SITE PREDICTION OF OVERSTRESS IN AN AIRCRAFT MUNITIONS CARRIER SO JOURNAL OF THE IES LA English DT Article DE STRESS PREDICTION; STRAIN GAUGE; DYNAMIC TESTING; MODELING; FATIGUE LIFE AB Vibration and strain data were measured on a modified munitions trailer to ensure that the design strength criteria had not been exceeded. These data were used in conjunction with a computer model to determine if the stress levels were sufficiently low to allow adequate fatigue life without further modification to the trailer. By combining standard data verification techniques with a stress prediction. technique, data from a number of channels were reviewed at the test site to determine the severity of measured levels. This information was used to control the test process. RP YOWELL, L (reprint author), USA,COMBAT SYST TEST ACT,ABERDEEN PROVING GROUND,MD, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INST ENVIRONMENTAL SCI PI MOUNT PROSPECT PA 940 E NORTHWEST HIGHWAY, MOUNT PROSPECT, IL 60056 SN 1052-2883 J9 J IES JI J. IES PD MAY-JUN PY 1995 VL 38 IS 3 BP 26 EP 29 PG 4 WC Engineering, Environmental; Environmental Sciences; Instruments & Instrumentation SC Engineering; Environmental Sciences & Ecology; Instruments & Instrumentation GA RE003 UT WOS:A1995RE00300004 ER PT J AU HILL, SC SALEHEEN, HI FULLER, KA AF HILL, SC SALEHEEN, HI FULLER, KA TI VOLUME CURRENT METHOD FOR MODELING LIGHT-SCATTERING BY INHOMOGENEOUSLY PERTURBED SPHERES SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID MORPHOLOGY-DEPENDENT RESONANCES; TIME-INDEPENDENT PERTURBATION; SMALL PARTICLES; RADIATION; DROPLET; SYSTEMS AB A volume current method (VCM) for calculating the optical scattering by inhomogeneous spheres is presented. The method is applicable to spheres having small refractive-index perturbations. In this method the internal and scattered fields are approximated with a separation-of-variables solution, in which each mode has its own effective-average refractive index. These fields generate an additional volume polarization current in the regions where the refractive index differs from the average refractive index of the sphere. The fields radiated by these polarization currents are then added to the approximate fields radiated by the unperturbed sphere. When they are tested with off-centered layered spheres, the fields calculated with the VCM compare well with those found with separation of variables so long as the changes in the refractive index are small. When the host sphere is near resonance and the perturbation is in a region where the resonant fields are large, the perturbations must be smaller than when the sphere is off resonance. C1 NEW MEXICO STATE UNIV,DEPT ELECT & COMP ENGN,LAS CRUCES,NM 88003. COLORADO STATE UNIV,DEPT ATMOSPHER SCI,FT COLLINS,CO 80523. RP HILL, SC (reprint author), USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 39 TC 23 Z9 23 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0740-3232 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD MAY PY 1995 VL 12 IS 5 BP 905 EP 915 DI 10.1364/JOSAA.12.000905 PG 11 WC Optics SC Optics GA QV029 UT WOS:A1995QV02900009 ER PT J AU CANNON, ML FINGER, MJ BULAS, DI AF CANNON, ML FINGER, MJ BULAS, DI TI MANUAL TESTICULAR DETORSION AIDED BY COLOR DOPPLER ULTRASONOGRAPHY SO JOURNAL OF ULTRASOUND IN MEDICINE LA English DT Note ID TORSION; SONOGRAPHY; US C1 CHILDRENS NATL MED CTR,DEPT DIAGNOST IMAGING & RADIOL,WASHINGTON,DC 20010. GEORGE WASHINGTON UNIV,SCH MED & HLTH SCI,WASHINGTON,DC 20052. UROL SERV,WASHINGTON,DC. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 11 TC 4 Z9 4 U1 0 U2 0 PU AMER INST ULTRASOUND MEDICINE PI LAUREL PA SUBSCRIPTION DEPT, 14750 SWEITZER LANE, STE 100, LAUREL, MD 20707-5906 SN 0278-4297 J9 J ULTRAS MED JI J. Ultrasound Med. PD MAY PY 1995 VL 14 IS 5 BP 407 EP 409 PG 3 WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging GA QY602 UT WOS:A1995QY60200015 PM 7609022 ER PT J AU MCLEOD, DG AF MCLEOD, DG TI PROSTATE-CANCER DIAGNOSIS SO JOURNAL OF UROLOGY LA English DT Editorial Material C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP MCLEOD, DG (reprint author), WALTER REED ARMY MED CTR,UROL SERV,BETHESDA,MD, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD MAY PY 1995 VL 153 IS 5 BP 1570 EP 1571 DI 10.1016/S0022-5347(01)67463-9 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA QR574 UT WOS:A1995QR57400059 PM 7536269 ER PT J AU CUOZZO, DW VACHHER, P SAU, P FRISHBERG, DP JAMES, WD AF CUOZZO, DW VACHHER, P SAU, P FRISHBERG, DP JAMES, WD TI VERRUCIFORM XANTHOMA - A BENIGN PENILE GROWTH SO JOURNAL OF UROLOGY LA English DT Note DE XANTHOMATOSIS; PENIS ID VERRUCIFORM-XANTHOMA; VULVA; LIGHT AB Verruciform xanthoma is a rare benign lesion. The majority of the cases occur on the oral mucosa. However, other sites, particularly the anogenital region, may be involved. We report the eleventh case in the literature of verruciform xanthoma of the penis. Genital verruciform xanthoma is significant because it can simulate verrucous carcinoma or invasive squamous cell carcinoma. Proper diagnosis by clinical recognition, adequate but limited biopsy and histopathological examination will avoid unnecessarily aggressive surgical procedures. The pertinent clinical and histological features of our case are described and the literature on penile verruciform xanthoma is reviewed. C1 WALTER REED ARMY MED CTR,SERV ANAT PATHOL,WASHINGTON,DC 20307. RP CUOZZO, DW (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 19 TC 10 Z9 10 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD MAY PY 1995 VL 153 IS 5 BP 1625 EP 1627 DI 10.1016/S0022-5347(01)67481-0 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA QR574 UT WOS:A1995QR57400077 PM 7714990 ER PT J AU MOUL, JW SNOW, PB FERNANDEZ, EB MAHER, PD SESTERHENN, IA AF MOUL, JW SNOW, PB FERNANDEZ, EB MAHER, PD SESTERHENN, IA TI NEURAL-NETWORK ANALYSIS OF QUANTITATIVE HISTOLOGICAL FACTORS TO PREDICT PATHOLOGICAL STAGE IN CLINICAL STAGE-I NONSEMINOMATOUS TESTICULAR CANCER SO JOURNAL OF UROLOGY LA English DT Article DE TESTICULAR NEOPLASMS; NEURAL NETWORKS; COMPUTER ID GERM-CELL TUMORS; MYOCARDIAL-INFARCTION; PROGNOSTIC FACTORS; DIAGNOSIS; SURVEILLANCE; TESTIS; HISTOPATHOLOGY; MULTIVARIATE; INTELLIGENCE; ORCHIECTOMY AB A great deal of controversy exists in staging clinical stage I (CSI) nonseminomatous testicular germ cell tumors (NSGCT) because of the difficulty of distinguishing true stage I patients from those with occult retroperitoneal or distant metastases. The goal of this study was to quantitate primary tumor histologic factors and to apply these in a neural network computer analysis to determine if more accurate staging could be achieved. All available primary tumor histological slides from 93 CSI NSGCT patients were analyzed for vascular invasion (VI), lymphatic invasion (LI), tunical invasion (TI) and quantitative determination of percentage of the primary tumor composed of embryonal carcinoma (%EMB), yolk sac carcinoma (%YS), teratoma (%TER) and seminoma (%SEM). These patients had undergone retroperitoneal lymphadenectomy or follow-up such that final stage included 55 pathologic stage I and 38 stage II or higher lesions. Two investigators were provided identical datasets for neural network analysis; one experienced researcher used custom Kohonen and back propagation programs and one less experienced researcher used a commercially available program. For each experiment, a subset of data was used for training, and subsets were blindly used to test the accuracy of the networks. In the custom back propagation network, 86 of 93 patients were correctly staged for an overall accuracy of 92% (sensitivity 88%, specificity 96%). Using Neural Ware commercial software 74 of 93 (79.6%) were accurately staged when all 7 input variables were used; however, accuracy improved from 84.9 to 87.1% when 2, 4 and 5 of the variables were used. Quantitative histologic assessment of the primary tumor and neural network processing of data may provide clinically useful information in the CSI NSGCT population; however, the expertise of the network researcher appears to be important, and commercial software in general use may not be superior to standard regression analysis. Prospective testing of expert methodology should be instituted to confirm its utility. C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. KAMAN SCI CORP,COLORADO SPRINGS,CO. ARMED FORCES INST PATHOL,DEPT GENITOURINARY PATHOL,WASHINGTON,DC 20306. RP MOUL, JW (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 40 TC 25 Z9 25 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD MAY PY 1995 VL 153 IS 5 BP 1674 EP 1677 DI 10.1016/S0022-5347(01)67502-5 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA QR574 UT WOS:A1995QR57400098 PM 7715008 ER PT J AU WILSON, RG PEARTON, SJ ABERNATHY, CR ZAVADA, JM AF WILSON, RG PEARTON, SJ ABERNATHY, CR ZAVADA, JM TI OUTDIFFUSION OF DEUTERIUM FROM GAN, ALN, AND INN SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A-VACUUM SURFACES AND FILMS LA English DT Article; Proceedings Paper CT 41st National Symposium of the American-Vacuum-Society CY OCT 24-28, 1994 CL DENVER, CO SP Amer Vacuum Soc C1 UNIV FLORIDA,DEPT MAT SCI & ENGN,GAINESVILLE,FL 32611. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP WILSON, RG (reprint author), HUGHES RES LABS,MALIBU,CA 90265, USA. NR 13 TC 34 Z9 34 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0734-2101 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A-Vac. Surf. Films PD MAY-JUN PY 1995 VL 13 IS 3 BP 719 EP 723 DI 10.1116/1.579814 PN 1 PG 5 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA RD766 UT WOS:A1995RD76600042 ER PT J AU MCLANE, GF CASAS, L LAREAU, RT ECKART, DW VARTULI, CB PEARTON, SJ ABERNATHY, CR AF MCLANE, GF CASAS, L LAREAU, RT ECKART, DW VARTULI, CB PEARTON, SJ ABERNATHY, CR TI MAGNETRON REACTIVE ION ETCHING OF ALN AND INN IN BCL3 PLASMAS SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A-VACUUM SURFACES AND FILMS LA English DT Article; Proceedings Paper CT 41st National Symposium of the American-Vacuum-Society CY OCT 24-28, 1994 CL DENVER, CO SP Amer Vacuum Soc ID MOLECULAR-BEAM EPITAXY; GAAS; DRY; GAN C1 UNIV FLORIDA,DEPT MAT SCI & ENGN,GAINESVILLE,FL 32611. RP MCLANE, GF (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 16 TC 6 Z9 6 U1 0 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0734-2101 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A-Vac. Surf. Films PD MAY-JUN PY 1995 VL 13 IS 3 BP 724 EP 726 DI 10.1116/1.579815 PN 1 PG 3 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA RD766 UT WOS:A1995RD76600043 ER PT J AU DEB, KK BENNETT, KW BRODY, PS AF DEB, KK BENNETT, KW BRODY, PS TI INVESTIGATION OF PYROELECTRIC CHARACTERISTICS OF LEAD TITANATE THIN-FILMS FOR MICROSENSOR APPLICATIONS SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A-VACUUM SURFACES AND FILMS LA English DT Article; Proceedings Paper CT 41st National Symposium of the American-Vacuum-Society CY OCT 24-28, 1994 CL DENVER, CO SP Amer Vacuum Soc ID PBTIO3; DETECTOR; FET C1 USA,RES LAB,ADELPHI,MD 20783. RP DEB, KK (reprint author), USA,RES LAB,FT BELVOIR,VA 22060, USA. NR 24 TC 8 Z9 8 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0734-2101 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A-Vac. Surf. Films PD MAY-JUN PY 1995 VL 13 IS 3 BP 1128 EP 1132 DI 10.1116/1.579598 PN 1 PG 5 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA RD766 UT WOS:A1995RD76600119 ER PT J AU DUBEY, M JONES, KA CASAS, LM ECKART, D PFEFFER, RL AF DUBEY, M JONES, KA CASAS, LM ECKART, D PFEFFER, RL TI SINGLE-CRYSTAL EPITAXIAL GE-BASED OHMIC CONTACT STRUCTURE FOR III-V NANOELECTRONIC AND MESOSCOPIC DEVICES SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article; Proceedings Paper CT 3rd International Conference on Nanometer-Scale Science and Technology CY OCT 24-28, 1994 CL DENVER, CO SP Amer Vacuum Soc, USN, Off Naval Res, USA, Army Res Off, Natl Sci Fdn ID NORMAL-GAAS; N-GAAS RP DUBEY, M (reprint author), USA,RES LAB,EPSID,AMSRL EP EC,FT MONMOUTH,NJ 07703, USA. NR 13 TC 0 Z9 0 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD MAY-JUN PY 1995 VL 13 IS 3 BP 1358 EP 1363 DI 10.1116/1.587853 PG 6 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA RD494 UT WOS:A1995RD49400101 ER PT J AU WAGNER, GW MACIVER, BK YANG, YC AF WAGNER, GW MACIVER, BK YANG, YC TI MAGIC-ANGLE-SPINNING NMR-STUDY OF ADSORBATE REACTIONS ON ACTIVATED-CHARCOAL SO LANGMUIR LA English DT Letter AB Magic angle spinning (MAS) NMR can distinguish between molecules adsorbed in monolayers within the micropores (>20 Angstrom) of activated charcoal and those present in multilayers or capillary-condensed liquid in the mesopores (20-500 Angstrom). The differentiation is possible due to the NMR shifts to low frequency induced by the large, diamagnetic susceptibility of the graphitic surface of the micropores (upon which primary adsorption occurs) in combination with slow molecular exchange between the micropores and mesopores. This study uses MAS NMR to characterize the adsorption and oxidation of 2-chloroethyl phenyl sulfide (CEPS) on activated charcoal. Micropore-filling by solvents and solvent displacement of micropore-adsorbed CEPS are also demonstrated for charcoal using this technique. C1 USA,ERDEC,RES & TECHNOL DIRECTORATE,ABERDEEN PROVING GROUND,MD 21010. RP WAGNER, GW (reprint author), GEOCENTERS INC,GUNPOWDER BRANCH,POB 68,ABERDEEN PROVING GROUND,MD 21010, USA. NR 9 TC 19 Z9 19 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0743-7463 J9 LANGMUIR JI Langmuir PD MAY PY 1995 VL 11 IS 5 BP 1439 EP 1442 DI 10.1021/la00005a006 PG 4 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA RA110 UT WOS:A1995RA11000007 ER PT J AU BRYZIK, W KAMO, R WOODS, M AF BRYZIK, W KAMO, R WOODS, M TI NITRIDE ION-BEAM MIXING OF PISTON RINGS FOR HIGH-TEMPERATURE DIESEL-ENGINE SO LUBRICATION ENGINEERING LA English DT Article DE SOLID LUBRICATION; WEAR REDUCTION; FRICTION REDUCTION AB Direct ion implantation and ion beam mixing surface treatment processes are being explored to enhance the friction and wear characteristics of piston rings for the adiabatic diesel engine. Bench test results to temperatures of 540 degrees C indicate that titanium nitride and chrome nitride ion beam mixing of M2 steel produces superior friction and wear properties compared to traditional plasma-sprayed chrome oxide and chrome carbide coatings. Friction was reduced by a factor of two and wear was reduced by a factor of 20. C1 ADIABAT INC,COLUMBUS,IN. WAYNE STATE UNIV,DEPT MECH ENGN,DETROIT,MI 48202. RP BRYZIK, W (reprint author), USA,TARDEC,WARREN,MI, USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU SOC TRIBOLOGISTS & LUBRICATION ENGINEERS PI PARK RIDGE PA 838 BUSSE HIGHWAY, PARK RIDGE, IL 60068 SN 0024-7154 J9 LUBR ENG JI Lubric. Eng. PD MAY PY 1995 VL 51 IS 5 BP 373 EP 379 PG 7 WC Engineering, Mechanical SC Engineering GA QX248 UT WOS:A1995QX24800004 ER PT J AU WHEELER, JS AF WHEELER, JS TI PRELUDE TO POWER - THE CRISIS OF 1649 AND THE FOUNDATION OF ENGLISH NAVAL POWER SO MARINERS MIRROR LA English DT Article RP WHEELER, JS (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 11 TC 0 Z9 0 U1 0 U2 0 PU SOC NAUTICAL RESEARCH PI LONDON PA NATIONAL MARITIME MUSEUM GREENWICH, LONDON, ENGLAND SE10 9NF SN 0025-3359 J9 MARINERS MIRROR JI Mar. Mirror PD MAY PY 1995 VL 81 IS 2 BP 148 EP 155 PG 8 WC History SC History GA RA367 UT WOS:A1995RA36700004 ER PT J AU CARLIN, K CARLIN, S AF CARLIN, K CARLIN, S TI GENESIS AND ACID-BASE SO MEDICAL HYPOTHESES LA English DT Article ID FOLLICLE-STIMULATING-HORMONE; GONADOTROPIN-RELEASING-HORMONE; LUTEINIZING-HORMONE; INTRACELLULAR PH; CELLS; HETEROGENEITY; INVITRO; GRANULOSA; RECEPTOR; BOVINE AB Perhaps the enigmatic etiology of cell specialization ultimately leading to organogenesis can be explained by the unusual combined application of some common mechanisms. Perhaps the combination of control of variable pH through compartmentalization, dialysis/diffusion gradients, and an electrophoresis plane impacts cells in zones causing the developmental patterns. Possibly pH is even manipulated at times to change the charge on molecules in order that attraction of opposite charges can be utilized. RP CARLIN, K (reprint author), BROOKE ARMY MED CTR,DEPT ENDOCRINOL,SAN ANTONIO,TX 78234, USA. NR 46 TC 0 Z9 0 U1 0 U2 0 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH, MIDLOTHIAN, SCOTLAND EH1 3AF SN 0306-9877 J9 MED HYPOTHESES JI Med. Hypotheses PD MAY PY 1995 VL 44 IS 5 BP 339 EP 346 DI 10.1016/0306-9877(95)90260-0 PG 8 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA RJ567 UT WOS:A1995RJ56700008 PM 8583964 ER PT J AU LAUDER, TD MOSES, FM AF LAUDER, TD MOSES, FM TI RECURRENT ABDOMINAL-PAIN FROM ABDOMINAL ADHESIONS IN AN ENDURANCE TRIATHLETE SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Note DE LAPAROSCOPY; ATHLETICS; GASTROINTESTINAL; RUNNING; TRIATHLETE ID GASTROINTESTINAL SYMPTOMS; DIAGNOSTIC LAPAROSCOPY; RUNNERS; EXERCISE; COMPLAINTS; DISORDERS AB Abdominal adhesions have been described as developing postoperatively and as developing ''spontaneously'' in patients over 60 yr old. To our knowledge, abdominal adhesions have not been described as an etiology of recurrent abdominal pain in young endurance athletes, without prior history of abdominal surgery. We present a 28-yr-old endurance triathlete with recurrent abdominal pain in which multiple diagnostic imaging studies were unable to diagnose the etiology. Diagnostic laparoscopy revealed adhesions between the ascending colon and the anterior abdominal wall. Laparoscopic adhesiolysis was performed successfully and the athlete resumed his training several weeks post-laparoscopy without symptoms. One year later, the athlete remains pain free. C1 WALTER REED ARMY MED CTR,PHYS MED & REHABIL SERV,WASHINGTON,DC. WALTER REED ARMY MED CTR,GASTROENTEROL SERV,WASHINGTON,DC. NR 22 TC 4 Z9 4 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 1995 VL 27 IS 5 BP 623 EP 625 PG 3 WC Sport Sciences SC Sport Sciences GA QW449 UT WOS:A1995QW44900001 PM 7674863 ER PT J AU MORRISSEY, MC HARMAN, EA JOHNSON, MJ AF MORRISSEY, MC HARMAN, EA JOHNSON, MJ TI RESISTANCE TRAINING MODES - SPECIFICITY AND EFFECTIVENESS SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Review DE STRENGTH; RESISTANCE; WEIGHT TRAINING; ISOMETRIC; ISOTONIC; ISOKINETIC; CONCENTRIC; ECCENTRIC; JOINT ANGLE; RANGE OF MOTION; SPEED; VELOCITY; STATIC; DYNAMIC; FORCE; TORQUE; REHABILITATION; PHYSICAL PERFORMANCE ID MUSCLE STRENGTH; QUADRICEPS FEMORIS; PEAK TORQUE; POWER; VELOCITY; ADAPTATIONS AB There is considerable demand for information on the effectiveness of various resistance exercises for improving physical performance, and on how exercise programs must match functional activities to produce the greatest performance gains (training specificity). Evidence supports exercise-type specificity; the greatest training effects occur when the same exercise type is used for both resting and training. Range-of-motion (ROM) specificity is supported; strength improvements are greatest at the exercised joint angles, with enough carryover to strengthen ROMs precluded from direct training due to injury. Velocity specificity is supported; strength gains are consistently greatest at the training velocity, with some carryover. Some studies have produced a training effect only for velocities at and below the training velocity while others have produced effects around the training velocity. The little, mainly isokinetic, evidence comparing different exercise velocities for improving functional performance suggests that faster exercise best improves fast athletic movements. Yet isometric exercise can improve actions like the vertical jump, which begin slowly. The rate of force application may be more important in training than actual movement speed. More research is needed into the specificity and efficacy of resistance exercise. Test populations should include both males and females of various ages and rehabilitation patients. C1 USA,ENVIRONM MED RES INST,DIV OCCUPAT PHYSIOL,NATICK,MA 01760. BOSTON UNIV,SARGENT COLL,DEPT HLTH SCI,NATICK,MA. NR 85 TC 137 Z9 141 U1 1 U2 20 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 1995 VL 27 IS 5 BP 648 EP 660 PG 13 WC Sport Sciences SC Sport Sciences GA QW449 UT WOS:A1995QW44900006 PM 7674868 ER PT J AU ZAPP, J THORNE, T AF ZAPP, J THORNE, T TI COMFORTABLE LABOR WITH INTRATHECAL NARCOTICS SO MILITARY MEDICINE LA English DT Article AB Aggressive pursuit of high-quality health care had guided the Health Service of the United States Army to establish a labor analgesia program within its hospitals. A dedicated Labor Epidural Service can be quite expensive, especially from the manpower standpoint. Therefore, the Anesthesia Service at Reynolds Army Community Hospital, Fort Sill, Oklahoma, implemented a program of intrathecal narcotic injection as an alternative to costly labor epidural analgesia, After reviewing a patient fact sheet, 150 laboring patients volunteered for labor intrathecal analgesia (LIA). Once active labor began, the patient received intrathecal morphine (0.25 mg) and fentanyl (25 mu g). The pain level before and after the LIA was evaluated by the visual analog schedule method. At 2 weeks follow-up the intrathecal narcotic-assisted labor was subjectively reported by the patients. Ninety-four percent of the patients agreed that the LIA worked well and that they would do it again. LIA was found to be a well-accepted, cost-saving, very effective approach to labor analgesia. RP ZAPP, J (reprint author), REYNOLDS ARMY COMMUNITY HOSP,ANESTHESIA SERV,FT SILL,OK 73503, USA. NR 0 TC 11 Z9 11 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 1995 VL 160 IS 5 BP 217 EP 219 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA RE457 UT WOS:A1995RE45700004 PM 7659207 ER PT J AU LAMIELL, JM AF LAMIELL, JM TI MODELING INTENSIVE-CARE UNIT CENSUS SO MILITARY MEDICINE LA English DT Article AB A mathematical model revealing the relationships between bed capacity, average patient admission rate, average patient length of stay, utilization rate, and overfill rate in intensive care units is developed and explained. Mathematical model predictions are compared to predictions of two kinds of discrete event intensive care unit simulations and to data from a variety of real intensive care units. This methodology applies to any intensive care unit or hospital ward. There is no significant (p < 0.05) difference between measured utilization and overfill rates assessed in actual intensive care units, the rates obtained by discrete event simulations, and the rates predicted by the intensive care unit model. The intensive care unit census model can enhance rational determination of intensive care unit bed and staff requirements. RP LAMIELL, JM (reprint author), USA,MED DEPT CTR & SCH,OFF CLIN INVEST REGULATORY,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 10 Z9 10 U1 1 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 1995 VL 160 IS 5 BP 227 EP 232 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA RE457 UT WOS:A1995RE45700007 PM 7659210 ER PT J AU ROTHBERG, JM KOSHES, RJ SHANAHAN, JE CHRISTMAN, KW AF ROTHBERG, JM KOSHES, RJ SHANAHAN, JE CHRISTMAN, KW TI MOBILIZATION AND REJECTION OF INDIVIDUAL READY RESERVE PERSONNEL IN OPERATIONS-DESERT-SHIELD-STORM AT A US ARMY QUARTERMASTER POST SO MILITARY MEDICINE LA English DT Article AB The Individual Ready Reserve (IRR) is an important component of the U,S. Army's total combat force. After Operations Desert Shield/Storm, we investigated the mobilization of soldiers with combat service support specialties from the IRR to a quartermaster training post. In the initial 2 weeks of activation prior to assignment and deployment, the soldiers went through medical and administrative screening, and general and specialized military training. During this period, a sizable portion (one-quarter) of IRR troops who reported to duty were rejected for a variety of reasons (overweight, inadequate dependent arrangements, etc.) and did not remain on active duty. Potential changes to the policies that led to these rejections are discussed. RP ROTHBERG, JM (reprint author), WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,WASHINGTON,DC, USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 1995 VL 160 IS 5 BP 240 EP 242 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA RE457 UT WOS:A1995RE45700010 PM 7659213 ER PT J AU CARTER, AM VANVLEET, MA AF CARTER, AM VANVLEET, MA TI CHAMPUS PSYCHIATRIC INPATIENT SAVINGS - MILITARY MANAGEMENT VERSUS CONTRACTOR, THE FORT-POLK EXPERIENCE SO MILITARY MEDICINE LA English DT Article AB Inpatient psychiatric costs were a significant part of the CHAMPUS bill at Bayne Jones Army Community Hospital, With implementation of Gateway to Care, a case management program was developed for intervention. In May 1993, Foundation Health Federal Services Inc, began a modified CHAMPUS Reform Initiative program providing an opportunity to retrospectively analyze two methods of managed care, Civilian hospital inpatient admissions for both programs during fiscal year (FY) 1993 were compared to corresponding periods in FY 1992. Under the case management program, admissions were reduced by 67%, occupied bed days by 74%, and costs by 76%, Under the Foundation Health Program, admissions were reduced by 13%, occupied bed days by 15%, and total costs by 42%. Both methods achieved savings over standard CHAMPUS. In spite of constraints that Foundation Health did not have, the case management program appeared to be more effective, demonstrating that a managed health care program directed by the hospital commander can significantly reduce costs. RP CARTER, AM (reprint author), USAMEDDAC,CMHS,FT LEAVENWORTH,KS 66027, USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 1995 VL 160 IS 5 BP 242 EP 247 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA RE457 UT WOS:A1995RE45700011 PM 7659214 ER PT J AU COQUILLA, BH LEWIS, CW AF COQUILLA, BH LEWIS, CW TI MANAGEMENT OF PSEUDOFOLLICULITIS BARBAE SO MILITARY MEDICINE LA English DT Article AB Pseudofolliculitis barbae is a common dermatologic condition primarily affecting black men who shave closely on a regular basis, Figures cited in the literature indicate 10 to 83% of black men have some form of it. Commonly encountered in the military, pseudofollliculitis barbae has caused significant problems in all commands, both medically and administratively. This article will review the pathogenesis of pseudofolliculitis barbae and provide a variety of treatment modalities, Proper treatment is essential to avoid unnecessary scarring, pigmentation, and keloid formation. RP COQUILLA, BH (reprint author), USA,MED DEPT ACTIV,FT POLK,LA 71459, USA. NR 0 TC 15 Z9 15 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 1995 VL 160 IS 5 BP 263 EP 269 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA RE457 UT WOS:A1995RE45700015 PM 7659218 ER PT J AU MCDIARMID, MA JACOBSONKRAM, D KOLODER, K DEETER, DP LACHIVER, RM SCOTT, BG PETRUCELLI, BP GUSTAVISON, D PUTMAN, D AF MCDIARMID, MA JACOBSONKRAM, D KOLODER, K DEETER, DP LACHIVER, RM SCOTT, BG PETRUCELLI, BP GUSTAVISON, D PUTMAN, D TI INCREASED FREQUENCIES OF SISTER-CHROMATID EXCHANGE IN SOLDIERS DEPLOYED TO KUWAIT SO MUTAGENESIS LA English DT Note ID PERIPHERAL-BLOOD LYMPHOCYTES AB Frequencies of sister chromatid exchange (SCE), a measure of genotoxic exposure, were assessed in military troops deployed to Kuwait in 1991. Soldiers completed health questionnaires and had blood collected prior to, during and following deployment to Kuwait. Frequency of spontaneous SCE was determined on blood samples as a measure of mutagenic exposure. Compared to pre-deployment baseline SCE frequency means, levels obtained 2 months into the Kuwaiti deployment were significantly increased (P < 0.001) and persisted for at least 1 month after return to Germany. Outcome was unaffected by known personal SCE effect modifiers including smoking, age and diet. Potential sources of the apparent mutagenic exposure are discussed. C1 MICROBIOL ASSOCIATES INC,ROCKVILLE,MD. USA,MED DEPT CTR & SCH,FT SAM HOUSTON,TX. HILTON HEAD HOSP,HILTON HEAD ISL,SC,BRAZIL. USA,SPECIAL OPERAT COMMAND,FT BRAGG,NC 28307. WALTER REED ARMY INST RES,DIV PREVENT MED,WASHINGTON,DC 20307. USA,ARMAMENT MUNIT & CHEM COMMAND,ROCK ISL,IL. USA,ENVIRONM HYG AGCY,DIV ENVIRONM & OCCUPAT MED,ABERDEEN PROVING GROUND,MD 21010. RP MCDIARMID, MA (reprint author), JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,615 N WOLFE ST,BALTIMORE,MD 21205, USA. NR 15 TC 12 Z9 12 U1 0 U2 0 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0267-8357 J9 MUTAGENESIS JI Mutagenesis PD MAY PY 1995 VL 10 IS 3 BP 263 EP 265 DI 10.1093/mutage/10.3.263 PG 3 WC Genetics & Heredity; Toxicology SC Genetics & Heredity; Toxicology GA RB038 UT WOS:A1995RB03800018 PM 7666779 ER PT J AU SHANLEY, DJ AF SHANLEY, DJ TI MINERALIZING MICROANGIOPATHY - CT AND MRI SO NEURORADIOLOGY LA English DT Article DE MINERALIZING MICROANGIOPATHY; CHEMOTHERAPY; RADIOTHERAPY; COMPUTED TOMOGRAPHY; MAGNETIC RESONANCE IMAGING ID CENTRAL NERVOUS-SYSTEM; ACUTE LYMPHOCYTIC-LEUKEMIA; RADIATION-INJURY; BASAL GANGLIA; BRAIN-TUMOR; CHILDREN; CALCIFICATION; CHEMOTHERAPY; METHOTREXATE; CHILDHOOD AB Mineralizing microangiopathy, a distinctive histopathologic process involving the microvasculature of the central nervous system (CNS), is usually seen following combined radiation and chemotherapy for the treatment of CNS neoplasms in childhood. CT typically demonstrates calcification within the basal ganglia and subcortical white matter. The areas of calcification may give paradoxically increased signal on T1-weighted MRI due to a surface-relaxation mechanism, and decreased signal on T2-weighted images. RP SHANLEY, DJ (reprint author), TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859, USA. NR 16 TC 21 Z9 21 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0028-3940 J9 NEURORADIOLOGY JI Neuroradiology PD MAY PY 1995 VL 37 IS 4 BP 331 EP 333 PG 3 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA RA264 UT WOS:A1995RA26400021 PM 7666975 ER PT J AU DAVANLOO, F BOROVINA, DL COLLINS, CB AGEE, FJ KINGSLEY, LE AF DAVANLOO, F BOROVINA, DL COLLINS, CB AGEE, FJ KINGSLEY, LE TI REPETITIVELY PULSED HIGH-POWER STACKED BLUMLEIN GENERATORS SO NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS LA English DT Article; Proceedings Paper CT 13th International Conference on the Application of Accelerators in Research and Industry CY NOV 07-10, 1994 CL DENTON, TX SP US DOE, Natl Sci Fdn, Univ N Texas AB The stacked Blumlein pulse generators developed at the University of Texas at Dallas consist of several triaxial Blumleins stacked in series at one end. The lines are charged in parallel and synchronously commuted with a single switching element at the other end. In this way, relatively low charging voltages are multiplied to give the desired discharge voltage across an arbitrary load. Described here is the progress in development and characterization of these novel pulse-power generators capable of discharging at high repetition rates. The introduction of a tapered transmission line concept to the stacked Blumlein design provided fine tuning of output waveforms. C1 PHILLIPS LAB,PL WSR,KIRTLAND AFB,NM 87117. USA,RES LAB,EPSD,FT MONMOUTH,NJ 07703. RP DAVANLOO, F (reprint author), UNIV TEXAS,CTR QUANTUM ELECTR,POB 830688,RICHARDSON,TX 75083, USA. NR 7 TC 1 Z9 1 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-583X J9 NUCL INSTRUM METH B JI Nucl. Instrum. Methods Phys. Res. Sect. B-Beam Interact. Mater. Atoms PD MAY PY 1995 VL 99 IS 1-4 BP 713 EP 716 DI 10.1016/0168-583X(94)00549-4 PG 4 WC Instruments & Instrumentation; Nuclear Science & Technology; Physics, Atomic, Molecular & Chemical; Physics, Nuclear SC Instruments & Instrumentation; Nuclear Science & Technology; Physics GA RK760 UT WOS:A1995RK76000187 ER PT J AU WOOD, GL MILLER, MJ MOTT, AG AF WOOD, GL MILLER, MJ MOTT, AG TI INVESTIGATION OF TETRABENZPORPHYRIN BY THE Z-SCAN TECHNIQUE SO OPTICS LETTERS LA English DT Article ID 3RD-ORDER AB The nonlinear transmission of tetrabenzporphyrin dissolved in tetrahydrofuran was measured with the Z-scan technique at 532 nm with nanosecond pulses. The excited-state absorption cross section, the excited-state refractive-index cross section, and the linear and nonlinear absorption contributing to a thermal index change have been determined. To our knowledge, the excited-state cross section and its effective ratio to the ground-state cross section are the largest values reported to date. RP WOOD, GL (reprint author), USA,RES LAB,FT BELVOIR,VA 22060, USA. NR 10 TC 116 Z9 117 U1 0 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD MAY 1 PY 1995 VL 20 IS 9 BP 973 EP 975 DI 10.1364/OL.20.000973 PG 3 WC Optics SC Optics GA QV829 UT WOS:A1995QV82900009 PM 19859394 ER PT J AU MATHER, B AF MATHER, B TI ALKALI-AGGREGATE REACTIVITY - A SUMMARY SO PCI JOURNAL LA English DT Discussion C1 USA,WATERWAYS EXPT STN,STRUCT LAB,VICKSBURG,MS 39180. NR 0 TC 0 Z9 0 U1 0 U2 1 PU PRECAST/PRESTRESSED CONCRETE INST PI CHICAGO PA 175 W JACKSON BLVD, CHICAGO, IL 60604 SN 0887-9672 J9 PCI J JI PCI J. PD MAY-JUN PY 1995 VL 40 IS 3 BP 124 EP 125 PG 2 WC Construction & Building Technology SC Construction & Building Technology GA RF865 UT WOS:A1995RF86500007 ER PT J AU CIESLAK, TJ IRWIN, RG DOUGHERTY, PA MILLER, GM AF CIESLAK, TJ IRWIN, RG DOUGHERTY, PA MILLER, GM TI A PSEUDOEPIDEMIC OF TUBERCULIN SKIN-TEST CONVERSIONS CAUSED BY A PARTICULAR LOT OF PURIFIED PROTEIN DERIVATIVE OF TUBERCULIN TEST SOLUTION SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Note DE MANTOUX TEST; TUBERCULIN TEST; MASS SCREENING; TUBERCULOSIS RP CIESLAK, TJ (reprint author), BROOKE ARMY MED CTR,DEPT PEDIAT,FT SAM HOUSTON,TX 78234, USA. NR 8 TC 7 Z9 7 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD MAY PY 1995 VL 14 IS 5 BP 392 EP 393 DI 10.1097/00006454-199505000-00011 PG 2 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA QX698 UT WOS:A1995QX69800012 PM 7638016 ER PT J AU SCALORA, M BOWDEN, CM AF SCALORA, M BOWDEN, CM TI PROPAGATION EFFECTS AND ULTRAFAST OPTICAL SWITCHING IN DENSE MEDIA SO PHYSICAL REVIEW A LA English DT Article ID 2-LEVEL ATOMS; RESONANT MEDIUM; BISTABILITY; REFLECTION RP SCALORA, M (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,ST,WS,RD,AMSMI,WEAP SCI DIRECTORATE,HUNTSVILLE,AL 35899, USA. NR 29 TC 18 Z9 18 U1 0 U2 2 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD MAY PY 1995 VL 51 IS 5 BP 4048 EP 4056 DI 10.1103/PhysRevA.51.4048 PG 9 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA RA431 UT WOS:A1995RA43100087 ER PT J AU BOWDEN, CM AGRAWAL, GP AF BOWDEN, CM AGRAWAL, GP TI MAXWELL-BLOCH FORMULATION FOR SEMICONDUCTORS - EFFECTS OF COHERENT COULOMB EXCHANGE SO PHYSICAL REVIEW A LA English DT Article ID 2-LEVEL ATOMS; OPTICAL BISTABILITY; QUANTUM WELLS; DENSE MEDIUM; LASERS; SATURATION; EQUATIONS; EXCITONS; CDS C1 UNIV ROCHESTER,INST OPT,ROCHESTER,NY 14627. RP BOWDEN, CM (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,ST,WS,RD,AMSMI,WEAP SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. RI Agrawal, Govind/D-5380-2013 OI Agrawal, Govind/0000-0003-4486-8533 NR 35 TC 38 Z9 38 U1 1 U2 5 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD MAY PY 1995 VL 51 IS 5 BP 4132 EP 4139 DI 10.1103/PhysRevA.51.4132 PG 8 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA RA431 UT WOS:A1995RA43100096 ER PT J AU BENSON, CJ SCHRECK, RC UNDERWOOD, FB GREATHOUSE, DG AF BENSON, CJ SCHRECK, RC UNDERWOOD, FB GREATHOUSE, DG TI THE ROLE OF ARMY PHYSICAL-THERAPISTS AS NONPHYSICIAN HEALTH-CARE PROVIDERS WHO PRESCRIBE CERTAIN MEDICATIONS - OBSERVATIONS AND EXPERIENCES SO PHYSICAL THERAPY LA English DT Article DE NEUROMUSCULOSKELETAL; ORTHOPEDICS; PHARMACOLOGICAL MEDICATION; PHYSICAL THERAPY AB For two decades, Army physical therapists have been granted limited privileges to prescribe certain medications when serving as nonphysician health care providers for the primary evaluation and treatment of patients with neuromusculoskeletal dysfunctions. A brief summary of the events that led to this physician-extender role is presented. This article describes the Army regulations, credentialing process, and expanded clinical privileges developed to prepare and support physical therapists working as primary neuromusculoskeletal screeners who are credentialed to order certain pharmacologic medications. A historical synopsis of Army physical therapists ordering pharmacologic medications in their expanded role as nonphysician health care providers is also presented. Results of a 1994 Army-wide survey of physical therapy clinics are provided in terms of medications prescribed and observations by those involved. The educational opportunities designed to ensure safe and appropriate uses of these privileges are described. C1 USA,HEADQUARTERS,OFF SURGEON GEN,FALLS CHURCH,VA 22041. TRIPLER ARMY MED CTR,HONOLULU,HI 96859. USA,CTR MED DEPT,GRAD PROGRAM PHYS THERAPY,HOUSTON,TX 78234. USA,BAYLOR UNIV,HOUSTON,TX 78234. NR 11 TC 15 Z9 16 U1 0 U2 0 PU AMER PHYS THER ASSN PI ALEXANDRIA PA 1111 N FAIRFAX ST, ALEXANDRIA, VA 22314 SN 0031-9023 J9 PHYS THER JI Phys. Ther. PD MAY PY 1995 VL 75 IS 5 BP 380 EP 386 PG 7 WC Orthopedics; Rehabilitation SC Orthopedics; Rehabilitation GA QW072 UT WOS:A1995QW07200007 PM 7732082 ER PT J AU DAI, WL WOODWARD, PR AF DAI, WL WOODWARD, PR TI A STUDY TOR THE INTERACTION BETWEEN SOLAR-WIND IRREGULARITIES AND THE MAGNETOSPHERE THROUGH 3-DIMENSIONAL SIMULATIONS SO PHYSICS OF PLASMAS LA English DT Article ID KELVIN-HELMHOLTZ INSTABILITY; IMPULSIVE PENETRATION; MAGNETOPAUSE-BOUNDARY; DAYSIDE MAGNETOPAUSE; PLASMA ELEMENTS RP DAI, WL (reprint author), UNIV MINNESOTA, SCH PHYS & ASTRON, ARMY HIGH PERFORMANCE COMP RES CTR, INST SUPERCOMP, MINNEAPOLIS, MN 55415 USA. NR 17 TC 3 Z9 3 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 1070-664X EI 1089-7674 J9 PHYS PLASMAS JI Phys. Plasmas PD MAY PY 1995 VL 2 IS 5 BP 1725 EP 1734 DI 10.1063/1.871320 PG 10 WC Physics, Fluids & Plasmas SC Physics GA QZ330 UT WOS:A1995QZ33000041 ER PT J AU LARSEN, TB YUEN, DA MALEVSKY, AV SMEDSMO, JL AF LARSEN, TB YUEN, DA MALEVSKY, AV SMEDSMO, JL TI DYNAMICS OF THERMAL-CONVECTION WITH NEWTONIAN TEMPERATURE-DEPENDENT VISCOSITY AT HIGH RAYLEIGH NUMBER SO PHYSICS OF THE EARTH AND PLANETARY INTERIORS LA English DT Article ID INFINITE PRANDTL NUMBER; FREE UPPER BOUNDARY; MANTLE CONVECTION; EARTHS MANTLE; HEAT-TRANSPORT; HISTORY; MODELS; TURBULENCE; EVOLUTION; ANOMALIES AB Two-dimensional, time-dependent convection with a Newtonian temperature-dependent viscosity has been investigated in wide aspect-ratio boxes. Large-scale circulations have been found in the regime with volumetrically averaged Rayleigh numbers, Ra-v ranging between O(10(5)) and O(10(8)). Viscosity contrasts up to 1000 have been examined. The horizontally averaged temperature in the interior, [T](1/2), does not vary much within the above range of Ra-v for large-aspect-ratio boxes. The horizontal Fourier spectra of the viscosity field show a decrease of magnitude in the viscosity with shorter wavelength. The viscosity spectra decay differently with decreasing wavelength than the corresponding thermal spectra. Lithospheric processes, such as lubrication of subduction and lithospheric thinning, are facilitated by high Ra-v. The vertical correlation function for the temperature anomalies used recently for comparing convection calculations with tomographic models is found to be strongly time-dependent for Ra-v O(10(6)). The temporal fluctuations of the vertical correlation function decrease for higher Rayleigh numbers. Correlation functions for low Ra are broad and smooth, while those for high Ra, greater than 10(7), are narrow and fragmented. C1 UNIV MINNESOTA,DEPT GEOL & GEOPHYS,MINNEAPOLIS,MN 55415. UNIV MINNESOTA,MINNESOTA SUPERCOMP INST,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55415. NR 38 TC 6 Z9 6 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0031-9201 J9 PHYS EARTH PLANET IN JI Phys. Earth Planet. Inter. PD MAY PY 1995 VL 89 IS 1-2 BP 9 EP 33 DI 10.1016/0031-9201(94)03002-Z PG 25 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA QV364 UT WOS:A1995QV36400002 ER PT J AU DOWLING, J AF DOWLING, J TI MIRROR, MIRROR, ON THE WALL - IS THE PHOTON THERE AT ALL SO PHYSICS WORLD LA English DT Article RP DOWLING, J (reprint author), USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898, USA. NR 0 TC 2 Z9 2 U1 0 U2 1 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0953-8585 J9 PHYS WORLD JI Phys. World PD MAY PY 1995 VL 8 IS 5 BP 23 EP 24 PG 2 WC Physics, Multidisciplinary SC Physics GA QY433 UT WOS:A1995QY43300030 ER PT J AU SOICHER, H GORMAN, FJ TSEDILINA, EE WEITSMAN, OV AF SOICHER, H GORMAN, FJ TSEDILINA, EE WEITSMAN, OV TI IONOSPHERIC F(0)F(2) VALUES AND THEIR GRADIENTS AT EUROPEAN LONGITUDES SO RADIO SCIENCE LA English DT Article; Proceedings Paper CT Ionospheric Effects Symposium (IES 93) CY 1993 CL ALEXANDRIA, VA SP USN, NAVAL RES LAB, PHILLIPS LAB, USA, SPACE & TERRESTRIAL COMMUN DIRECTORATE, USN, OFF NAVAL RES AB Ionospheric f(o)F(2) values were deduced from vertical ionograms taken near the maximum of the current solar cycle at three European locations during 1990-1991: Dourbes, Belgium (50.1 degrees N, 4.6 degrees E); Roquetes, Tarragona, Spain (40.8 degrees N, 0.3 degrees E); and Pome, Italy (41.9 degrees N, 12.5 degrees). The three stations form a nearly equilateral triangle with a base distance of similar to 1100 km. Diurnal, day-to-day, as well as seasonal variations are evident for the parameter and its gradients. Cross-correlation analysis was performed to assess the predictability of the ionospheric variability at one locale based on real-time measurement at another. C1 TEL AVIV UNIV,DEPT GEOPHYS & PLANETARY SCI,RAMAT AVIV,ISRAEL. RP SOICHER, H (reprint author), USA,COMMUNICAT ELECTR COMMAND,FT MONMOUTH,NJ 07703, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0048-6604 J9 RADIO SCI JI Radio Sci. PD MAY-JUN PY 1995 VL 30 IS 3 BP 755 EP 764 DI 10.1029/94RS03178 PG 10 WC Astronomy & Astrophysics; Geochemistry & Geophysics; Meteorology & Atmospheric Sciences; Remote Sensing; Telecommunications SC Astronomy & Astrophysics; Geochemistry & Geophysics; Meteorology & Atmospheric Sciences; Remote Sensing; Telecommunications GA RB414 UT WOS:A1995RB41400025 ER PT J AU THWAITES, BK POWELL, DR AF THWAITES, BK POWELL, DR TI INTERPLEURAL BLOCK FOR ACUTE COMBINED CERVICAL AND THORACIC HERPES-ZOSTER SO REGIONAL ANESTHESIA LA English DT Letter RP THWAITES, BK (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 6 Z9 6 U1 0 U2 0 PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS PI NEW YORK PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011 SN 0146-521X J9 REGION ANESTH JI Reg. Anesth. PD MAY-JUN PY 1995 VL 20 IS 3 BP 255 EP 256 PG 2 WC Anesthesiology SC Anesthesiology GA RA086 UT WOS:A1995RA08600020 PM 7547670 ER PT J AU QUIGLEY, CJ MEAD, J JOHNSON, AR AF QUIGLEY, CJ MEAD, J JOHNSON, AR TI LARGE-STRAIN VISCOELASTIC CONSTITUTIVE MODELS FOR RUBBER .2. DETERMINATION OF MATERIAL CONSTANTS SO RUBBER CHEMISTRY AND TECHNOLOGY LA English DT Article ID BEHAVIOR AB A method for determining material constants in large strain viscoelastic materials was demonstrated for a highly saturated nitrile rubber. Material constant selection was based an viscoelastic stress relaxation data at small and large strains, under both tension and compression, and was constrained to assure Drucker stability. Assuming that the viscoelastic strain energy function was both time and strain separable, a Prony series was constructed for the time dependent material constants. For comparison, four different Prony series were developed from collocation methods and a nonlinear regression analysis, each separately based on either large or small tensile strain relaxation data. III addition, a final Prony series was constructed from dynamic data. These Prony series were included in this comparison to judge their ability to predict both large and small strain material behavior. Finite element analyses of large and small step-strain relaxation tests and a single cycle hysteresis loop at large deformations were performed for each set of Prony series. The results were then compared to experimental behavior. The Prony series based on the constrained method accurately predicted step-strain relaxation behavior at all strain levels, for both tension and compression. The finite element results for the other Prony series show that large strain material behavior was best predicted by those Prony series based on large strain material behavior. Similar findings were found for small strain material behavior. The constrained Prony series and the two large strain based Prony series best modeled the experimental hysteresis loop. C1 NASA,LANGLEY RES CTR,USA,RES LAB,VEHICLE STRUCT DIRECTORATE,HAMPTON,VA 23681. RP QUIGLEY, CJ (reprint author), USA,RES LAB,MAT DIRECTORATE,WATERTOWN,MA 02172, USA. NR 27 TC 16 Z9 16 U1 0 U2 4 PU AMER CHEMICAL SOC INC PI AKRON PA RUBBER DIV UNIV AKRON PO BOX 499, AKRON, OH 44309-0499 SN 0035-9475 J9 RUBBER CHEM TECHNOL JI Rubber Chem. Technol. PD MAY-JUN PY 1995 VL 68 IS 2 BP 230 EP 247 DI 10.5254/1.3538738 PG 18 WC Polymer Science SC Polymer Science GA RG264 UT WOS:A1995RG26400005 ER PT J AU JOHNSON, KB CHARYA, RV WIESMANN, WP PEARCE, FJ AF JOHNSON, KB CHARYA, RV WIESMANN, WP PEARCE, FJ TI PLASMA AND TISSUE HISTAMINE CHANGES DURING HEMORRHAGIC-SHOCK IN THE RAT SO SHOCK LA English DT Article ID DIAMINE OXIDASE; CARNOSINE; ISCHEMIA; BLOCKERS; RELEASE; PHASE AB We investigated the phase-associated changes in plasma histamine levels in an isobaric model of hemorrhagic shock, in an attempt to determine whether histamine might be an etiologic factor in the onset of decompensation. Sprague-Dawley rats were bled according to an isobaric bleeding protocol which maintained the mean arterial blood pressure at 40 mmHg until death. The status of vascular compensation for the blood loss was tracked by measurement of the shed blood volume (SBV) required to maintain the target pressure. Blood samples for analysis were taken at the control period and at 25% intervals of the peak shed blood volume (PSBV) during the compensatory and decompensatory phases. Plasma and tissue histamine levels were measured using a radioimmunoassay method. In untreated animals, plasma histamine levels at control, 75 and 100% of the PSBV, and after return of 25 and 75% of the PSBV were 45 +/- 10, 48 +/- 9, 134 +/- 48, 693 +/- 351, and 994 +/- 371 nM, respectively. These results show that rises in plasma histamine occurred coincidentally with the onset of decompensation (p < .05), however, the subsequent rate of decompensation did not correlate with plasma histamine changes during decompensation. Organ histamine levels measured after hemorrhage were lower in the duodenum and colon than in unbled control animals, suggesting that parts of the intestinal tract may contribute to the elevated plasma histamine levels seen in severe hypotension (p < .05). C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV SURG,WASHINGTON,DC 20307. NR 35 TC 13 Z9 14 U1 0 U2 0 PU BIOMEDICAL PRESS PI AUGUSTA PA 1021 15TH ST, BIOTECH PARK STE 9, AUGUSTA, GA 30901 SN 1073-2322 J9 SHOCK JI Shock PD MAY PY 1995 VL 3 IS 5 BP 343 EP 349 PG 7 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA QY848 UT WOS:A1995QY84800005 PM 7648335 ER PT J AU GAGLIARDI, JA EVANS, EM CHANDNANI, VP MYERS, JB PACHECO, CM AF GAGLIARDI, JA EVANS, EM CHANDNANI, VP MYERS, JB PACHECO, CM TI OSTEOGENESIS IMPERFECTA COMPLICATED BY OSTEOSARCOMA SO SKELETAL RADIOLOGY LA English DT Note C1 TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT PATHOL,HONOLULU,HI 96859. USA,HOSP COMBAT SUPPORT 67TH,DEPT RADIOL,WURZBURG,GERMANY. NR 8 TC 9 Z9 9 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0364-2348 J9 SKELETAL RADIOL JI Skeletal Radiol. PD MAY PY 1995 VL 24 IS 4 BP 308 EP 310 PG 3 WC Orthopedics; Radiology, Nuclear Medicine & Medical Imaging SC Orthopedics; Radiology, Nuclear Medicine & Medical Imaging GA QY621 UT WOS:A1995QY62100017 PM 7544031 ER PT J AU THORPY, M CHESSON, A DERDERIAN, S KADER, G POTOLICCHIO, S ROSEN, G STROLLO, PJ CHEDIAK, A FERBER, R REITE, M WOOTEN, V AF THORPY, M CHESSON, A DERDERIAN, S KADER, G POTOLICCHIO, S ROSEN, G STROLLO, PJ CHEDIAK, A FERBER, R REITE, M WOOTEN, V TI PRACTICE PARAMETERS FOR THE USE OF ACTIGRAPHY IN THE CLINICAL-ASSESSMENT OF SLEEP DISORDERS SO SLEEP LA English DT Editorial Material DE ACTIGRAPHY; INSOMNIA; MOVEMENT; PHYSIOLOGICAL MONITORING; PRACTICE GUIDELINES; SLEEP; SLEEP DISORDERS AB These clinical guidelines, which have been reviewed and approved by the Board of Directors of the American Sleep Disorders Association, provide recommendations for the practice of sleep medicine in North America for the use of actigraphy in the clinical assessment of sleep disorders. The American Sleep Disorders Association has produced these guidelines, based upon a critical review of the scientific literature, regarding the use of actigraphy in the clinical evaluation of sleep disorders. Though not indicated for the routine assessment of sleep disorders, actigraphy may be a useful adjunct, in certain circumstances, to a detailed history and examination when demonstration of multiday rest-activity patterns is necessary to diagnose, document severity, and guide proper treatment of sleep disorders. C1 MONTEFIORE MED CTR,CTR SLEEP WAKE DISORDERS,BRONX,NY 10467. ALBERT EINSTEIN COLL MED,BRONX,NY 10467. LOUISIANA STATE UNIV,MED CTR,CTR SLEEP DISORDERS,SHREVEPORT,LA 71130. WALTER REED ARMY MED CTR,SLEEP DISORDERS RESP RES LAB,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. UNIV KANSAS,SCH MED,LAWRENCE,KS 66045. RHODE ISL HOSP,CTR SLEEP DISORDERS,PROVIDENCE,RI 02902. BROWN UNIV,PROVIDENCE,RI 02912. GEORGETOWN UNIV,CTR SLEEP DISORDERS,WASHINGTON,DC. HENNEPIN CTY MED CTR,CTR SLEEP DISORDERS,MINNEAPOLIS,MN. UNIV MINNESOTA,SCH MED,DEPT PEDIAT,MINNEAPOLIS,MN 55455. PULM SLEEP EVALUAT CTR,PITTSBURGH,PA. UNIV PITTSBURGH,SCH MED,PITTSBURGH,PA 15260. HCA WESLEY NEURODIAGNOST & SLEEP DISORDERS CTR,WICHITA,KS. NR 1 TC 97 Z9 100 U1 0 U2 4 PU AMER SLEEP DISORDERS ASSOC PI ROCHESTER PA 1610 14TH STREET NW SUITE 300, ROCHESTER, MN 55806 SN 0161-8105 J9 SLEEP JI Sleep PD MAY PY 1995 VL 18 IS 4 BP 285 EP 287 PG 3 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA QZ819 UT WOS:A1995QZ81900012 ER PT J AU MURPHY, FT MANOWN, TJ KNUTSON, SW ELIASSON, AH AF MURPHY, FT MANOWN, TJ KNUTSON, SW ELIASSON, AH TI EPINEPHRINE-INDUCED LACTIC-ACIDOSIS IN THE SETTING OF STATUS-ASTHMATICUS SO SOUTHERN MEDICAL JOURNAL LA English DT Note ID ACUTE BRONCHOSPASM; TERBUTALINE; HYPOKALEMIA; MANAGEMENT; MECHANISMS; THERAPY AB A relationship between intravenous epinephrine infusion and the development of lactic acidosis has been well described. We report a temporal association between the administration of subcutaneous epinephrine and the development of lactic acidosis in the setting of status asthmaticus. A 20-year-old woman with a history of asthma came to the emergency service in acute respiratory distress and was treated with subcutaneous epinephrine. Six hours later, serial arterial blood gas studies revealed the onset of a primary metabolic acidosis. Additional diagnostic studies revealed a serum lactate level of 9.5 mu mol/L. The lactic acidosis resolved within 15 hours. The patient never exhibited signs of hypotension, hypoxemia, or sepsis, and other potential etiologies for lactic acidosis were excluded. We believe the events of this case constitute a new observation and theorize a mechanism of peripheral vasoconstriction and transient tissue hypoperfusion mediated by the subcutaneous epinephrine. C1 WALTER REED ARMY MED CTR,PULM & CRIT CARE MED SERV,WASHINGTON,DC 20307. RP MURPHY, FT (reprint author), WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307, USA. NR 25 TC 9 Z9 9 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD MAY PY 1995 VL 88 IS 5 BP 577 EP 579 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA QX244 UT WOS:A1995QX24400014 PM 7732451 ER PT J AU KATRITZKY, AR BELYAKOV, SA CHENG, D DURST, HD AF KATRITZKY, AR BELYAKOV, SA CHENG, D DURST, HD TI SYNTHESES OF FORMAZANS UNDER PHASE-TRANSFER CONDITIONS SO SYNTHESIS-STUTTGART LA English DT Article DE FORMAZANS; SYNTHESIS; PHASE-TRANSFER CATALYSIS; TETRABUTYL-AMMONIUM SALTS; DICYCLOHEXANO-18-CROWN-6 AB Several 1,3,5-triarylformazans were synthesized (42-77 %) using a new methodology. Ate-coupling of aryldiazonium salts with arylaldehyde arylhydrazones under mild basic conditions in two-phase liquid-liquid media is efficiently promoted by phase-transfer catalysts (onium salts or dicyclohexano-18-crown-6) at 5-25 degrees C. The condensation of benzaldehyde with phenylhydrazine followed by phase-transfer catalyzed azo-coupling with phenyldiazonium chloride (one-pot procedure) gave 1,3,5-triphenylformazan in a 54 % yield without isolation of the intermediate benzaldehyde phenylhydrazone. A double ate-coupling reaction of phenyldiazonium chloride with 9 different CH-active compounds afforded corresponding formazan only in the case of phenylpyruvic acid. Reaction in malonamide gave 3-carbamoyl-1,5-diphenylformazan instead of the expected 1,5-diphenylformazan. C1 USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. RP KATRITZKY, AR (reprint author), UNIV FLORIDA,DEPT CHEM,CTR HETEROCYCL CPDS,GAINESVILLE,FL 32611, USA. NR 25 TC 29 Z9 29 U1 1 U2 5 PU GEORG THIEME VERLAG PI STUTTGART PA P O BOX 30 11 20, D-70451 STUTTGART, GERMANY SN 0039-7881 J9 SYNTHESIS-STUTTGART JI Synthesis PD MAY PY 1995 IS 5 BP 577 EP 581 PG 5 WC Chemistry, Organic SC Chemistry GA QY365 UT WOS:A1995QY36500020 ER PT J AU FERRARIS, JP HENDERSON, C TORRES, D MEEKER, D AF FERRARIS, JP HENDERSON, C TORRES, D MEEKER, D TI SYNTHESIS, SPECTROELECTROCHEMISTRY AND APPLICATION IN ELECTROCHROMIC DEVICES OF AN N-DOPABLE AND P-DOPABLE CONDUCTING POLYMER SO SYNTHETIC METALS LA English DT Article DE SYNTHESIS; SPECTROELECTROCHEMISTRY; ELECTROCHROMIC DEVICES; DOPING ID POLY(ISOTHIANAPHTHENE) AB The synthesis and spectroelectrochemistry of poly(cyclopenta[2,1 -b;4,3-b']dithiophen-4-(cyano,nonafluorobutylsulfonyl)-methylidene) (PCNFBS), a low bandgap conducting polymer which is both p- and n-dopable, are reported: A model electrochromic device incorporating this polymer as both the anode and the cathode is demonstrated. C1 USA,ENGINEER WATERWAYS EXPT STN,CEWES CCD RES GRP,VICKSBURG,MS 39180. RP FERRARIS, JP (reprint author), UNIV TEXAS,DEPT CHEM,RICHARDSON,TX 75083, USA. NR 23 TC 40 Z9 41 U1 0 U2 2 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0379-6779 J9 SYNTHETIC MET JI Synth. Met. PD MAY PY 1995 VL 72 IS 2 BP 147 EP 152 DI 10.1016/0379-6779(94)02331-R PG 6 WC Materials Science, Multidisciplinary; Physics, Condensed Matter; Polymer Science SC Materials Science; Physics; Polymer Science GA QZ816 UT WOS:A1995QZ81600007 ER PT J AU LAUMAKIS, PJ HARLOW, DG AF LAUMAKIS, PJ HARLOW, DG TI PROBABILITY FAILURE MODELING OF WOVEN FIBER NETWORKS SO TEXTILE RESEARCH JOURNAL LA English DT Article ID LOAD-SHARING SYSTEMS; FIBROUS MATERIALS; COMPOSITE-MATERIALS; PERCOLATION MODELS; TENSILE-STRENGTH; BREAKDOWN; APPROXIMATIONS; DISTRIBUTIONS; FRACTURE; BOUNDS AB A probability model is developed to describe the failure of a biaxially loaded woven fiber network. The system under consideration consists of fibers arranged in a mutually orthogonal, simple weave pattern. The primary goal is to estimate the cumulative distribution function for failure of the network as a function of the fiber properties and the failure mechanism. The two-dimensional load sharing model is applicable to systems consisting of different fibers and various biaxial loading conditions. An algorithm that explicitly computes the distribution function is developed and evaluated numerically. Results are qualitatively consistent with other lattice models. C1 LEHIGH UNIV,DEPT MECH ENGN & MECH,BETHLEHEM,PA 18015. RP LAUMAKIS, PJ (reprint author), US MIL ACAD,DEPT MATH SCI,W POINT,NY 10996, USA. NR 28 TC 1 Z9 1 U1 0 U2 1 PU TEXTILE RESEARCH INST PI PRINCETON PA PO BOX 625, PRINCETON, NJ 08540 SN 0040-5175 J9 TEXT RES J JI Text. Res. J. PD MAY PY 1995 VL 65 IS 5 BP 254 EP 264 DI 10.1177/004051759506500502 PG 11 WC Materials Science, Textiles SC Materials Science GA QV073 UT WOS:A1995QV07300002 ER PT J AU MATTIX, ME HUNT, RE WILHELMSEN, CL JOHNSON, AJ BAZE, WB AF MATTIX, ME HUNT, RE WILHELMSEN, CL JOHNSON, AJ BAZE, WB TI AEROSOLIZED STAPHYLOCOCCAL-ENTEROTOXIN B-INDUCED PULMONARY-LESIONS IN RHESUS-MONKEYS (MACACA-MULATTA) SO TOXICOLOGIC PATHOLOGY LA English DT Article DE BIOTOXIN; ENTEROTOXEMIA; PULMONARY EDEMA; SHOCK; SUPERANTIGEN; T-CELL MITOGEN; NONHUMAN PRIMATE AB The pathology of aerosolized staphylococcal enterotoxin B (SEE) was studied in the nonhuman primate. Six juvenile rhesus monkeys that received multiple lethal inhaled doses of SEE developed diarrhea and vomiting within 24 hr followed by depression, dyspnea, and shock. Three of 6 animals died by 52 hr. The most striking gross lesion in all 6 monkeys was diffuse severe pulmonary edema. Histologically, edema fluid was present within the peribronchiolar, peribronchial, and perivascular interstitium, alveolar septa, and alveoli. The adventitia of pulmonary vessels was infiltrated by lymphocytes, macrophages, and fewer neutrophils. Numerous large lymphocytes with occasional mitotic figures were within pulmonary vessels, often occluding alveolar capillaries. These cells were strongly immunoreactive with monoclonal antibodies against CD3, establishing them as T cells. Ultrastructurally, endothelial cell junctions were intact, and endothelial cells and type I pneumocytes contained numerous pinocytotic vesicles. Alveolar septal interstitial spaces were expanded by edema. The mechanism of these SEE-induced pulmonary lesions was not determined. We hypothesize that cytokine production by activated T cells may have caused vascular permeability changes leading to widespread pulmonary edema and shock. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV PATHOL,WASHINGTON,DC 20307. NR 0 TC 35 Z9 37 U1 0 U2 1 PU SOC TOXICOLOGIC PATHOLOGISTS PI LAWRENCE PA 1041 NEW HAMPSHIRE ST PO BOX 368, LAWRENCE, KS 66044 SN 0192-6233 J9 TOXICOL PATHOL JI Toxicol. Pathol. PD MAY-JUN PY 1995 VL 23 IS 3 BP 262 EP 268 PG 7 WC Pathology; Toxicology SC Pathology; Toxicology GA RD372 UT WOS:A1995RD37200004 PM 7659951 ER PT J AU KINKEAD, ER WOLFE, RE FLEMMING, CD CALDWELL, DJ MILLER, CR MARIT, GB AF KINKEAD, ER WOLFE, RE FLEMMING, CD CALDWELL, DJ MILLER, CR MARIT, GB TI REPRODUCTIVE TOXICITY SCREEN OF 1,3,5-TRINITROBENZENE ADMINISTERED IN THE DIET OF SPRAGUE-DAWLEY RATS SO TOXICOLOGY AND INDUSTRIAL HEALTH LA English DT Article DE DIETARY; EXPLOSIVES; METHEMOGLOBINEMIA; NITRATE; ORAL; REPRODUCTIVE SCREEN; TNB ID 1,3-DINITROBENZENE; TRINITROTOLUENE AB Several Army installations targeted for restoration have measurable quantities of 1,3,5-trinitrobenzene (TNB) in the soil and groundwater. As part of the process of developing environmental and health effects criteria for restoration, a modified Screening Information Data Set (SIDS) reproductive study was performed. Male and female Sprague-Dawley rats received a diet containing approximately 30, 150, or 300 mg TNB/kg diet. Mating occurred following 14 days of treatment. All darns, one-half the males, and representative pups were maintained for a total of 90 days of treatment. No mortality occurred during the study; however, a decrease in mean body weights was noted in both sexes of high-dose rats. A dose-related effect was noted in measurements of sperm function/activity. Sperm depletion and degeneration of the seminiferous tubules were noted histopathologically. Methemoglobinemia and splenic hemosiderosis were common findings in the high- and mid-dose levels of both sexes at necropsy. No adverse effects were noted in mating or fertility indices. No significant treatment-related differences were found in length of gestation, sex ratio, gestation index, or mean number of pups per litter. C1 USA,WALTER REED ARMY INST RES,MED RES DETACHMENT,WRIGHT PATTERSON AFB,OH. ARMSTRONG LAB,DIV TOXICOL,OCCUPAT & ENVIRONM HLTH DIRECTORATE,WRIGHT PATTERSON AFB,OH. RP KINKEAD, ER (reprint author), MANTECH ENVIRONM TECHNOL INC,POB 31009,DAYTON,OH 45437, USA. NR 23 TC 7 Z9 7 U1 0 U2 0 PU PRINCETON SCIENTIFIC PUBL INC PI PRINCETON PA PO BOX 2155, PRINCETON, NJ 08543 SN 0748-2337 J9 TOXICOL IND HEALTH JI Toxicol. Ind. Health PD MAY-JUN PY 1995 VL 11 IS 3 BP 309 EP 323 PG 15 WC Public, Environmental & Occupational Health; Toxicology SC Public, Environmental & Occupational Health; Toxicology GA RR535 UT WOS:A1995RR53500002 PM 7482571 ER PT J AU CHEN, YY AF CHEN, YY TI STATISTICAL-INFERENCE BASED ON THE POSSIBILITY AND BELIEF MEASURES SO TRANSACTIONS OF THE AMERICAN MATHEMATICAL SOCIETY LA English DT Article DE POSSIBILITY MEASURE; BELIEF MEASURE; LIKELIHOOD INFERENCE; HYPOTHESIS EVALUATION; LIKELIHOOD INTERVAL ID FUZZY AB In statistical inference, we infer the population parameter based on the realization of sample statistics. This can be considered in the framework of inductive inference. We showed, in Chen (1993), that if we measure a parameter by the possibility (or belief) measure, we can have an inductive inference similar to the Bayesian inference in belief update. In this article we apply this inference to statistical estimation and hypotheses evaluation (testing) for some parametric models, and compare them to the classical statistical inferences for both one-sample and two-sample problems. RP CHEN, YY (reprint author), USA,CONCEPT ANAL AGCY,BETHESDA,MD 20814, USA. NR 18 TC 8 Z9 8 U1 0 U2 2 PU AMER MATHEMATICAL SOC PI PROVIDENCE PA 201 CHARLES ST, PROVIDENCE, RI 02940-2213 SN 0002-9947 J9 T AM MATH SOC JI Trans. Am. Math. Soc. PD MAY PY 1995 VL 347 IS 5 BP 1855 EP 1863 DI 10.2307/2154981 PG 9 WC Mathematics SC Mathematics GA QY786 UT WOS:A1995QY78600023 ER PT J AU YAN, CH RILL, WL MALLI, R HEWETSON, J TAMMARIELLO, R KENDE, M AF YAN, CH RILL, WL MALLI, R HEWETSON, J TAMMARIELLO, R KENDE, M TI DEPENDENCE OF RICIN TOXOID VACCINE EFFICACY ON THE STRUCTURE OF POLY(LACTIDE-CO-GLYCOLIDE) MICROPARTICLE CARRIERS SO VACCINE LA English DT Article DE RICIN TOXOID VACCINE; POLY(LACTIDE-CO-GLYCOLIDE) MICROPARTICLES; CONTROLLED RELEASE; IMMUNIZATION; IGG TITER; AEROSOL CHALLENGE; PROTECTION ID BIODEGRADABLE MICROSPHERES; ADJUVANT; ANTIBODY; MICE; IMMUNIZATION; DELIVERY; INVITRO; ANTIGEN; RELEASE; CELLS AB Biodegradable microparticles made of poly(lactide-co-glycolide) (PLG) were used for protracted and pulsed-release of the incorporated ricin toroid (RT) vaccine to reduce the multiple immunization doses and the time required to induce complete protection against lethal aerosol-borne ricin challenge. The release rate of RT encapsulated in PLG microparticles was controlled by polymer selection and varying the preparation procedures, which allowed us to control microparticle size and the distribution of the vaccine in the polymeric matrix. PLG-microparticles in which RT vaccine was distributed heterogeneously in small pockets stimulated a rapid antibody response which was independent of the polymeric composition of the carriers. PLG-microparticles in which RT vaccine was distributed homogeneously throughout the polymeric matrix induced a slower antibody response, which depended on the polymeric composition of the carriers. Administration of RT in homogeneous microparticles made from 50/50 PLG or 100% polylactide stimulated two distinct anti-ricin IgG peaks, while RT in heterogeneous microparticles stimulated identical IgG peaks. An early (3 weeks) and long-lasting (1 year or longer) anti-ricin antibody response was evoked by a single administration of encapsulated RT vaccine when prepared by the above-mentioned conditions. In contrast, three administrations of the aqueous RT were required to stimulate similar antibody response. Reduction of immunization time from 6 to 4 weeks was achieved with RT encapsulated in small homogeneous microparticles but not with homogeneous large microparticles. These results demonstrated the usefulness of biodegradable microparticles to improve the efficacy of immunization with RT vaccine and probably many other vaccines as well. RP YAN, CH (reprint author), USA,MED RES INST INFECT DIS,FT DETRICK,FREDERICK,MD 21702, USA. NR 30 TC 16 Z9 17 U1 0 U2 1 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA LINACRE HOUSE JORDAN HILL, OXFORD, OXON, ENGLAND OX2 8DP SN 0264-410X J9 VACCINE JI Vaccine PD MAY PY 1995 VL 13 IS 7 BP 645 EP 651 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA RG404 UT WOS:A1995RG40400006 PM 7668034 ER PT J AU BEGUE, RE CASTELLARES, G RUIZ, R HAYASHI, KE SANCHEZ, JL GOTUZZO, E OBERST, RB TAYLOR, DN SVENNERHOLM, AM AF BEGUE, RE CASTELLARES, G RUIZ, R HAYASHI, KE SANCHEZ, JL GOTUZZO, E OBERST, RB TAYLOR, DN SVENNERHOLM, AM TI COMMUNITY-BASED ASSESSMENT OF SAFETY AND IMMUNOGENICITY OF THE WHOLE-CELL PLUS RECOMBINANT B-SUBUNIT (WC/RBS) ORAL CHOLERA VACCINE IN PERU SO VACCINE LA English DT Article DE CHOLERA; CHOLERA VACCINE; PERU ID ANTIBODY-RESPONSES; VIBRIO-CHOLERAE; FIELD TRIAL; BLOOD-GROUPS; FOLLOW-UP; BANGLADESH; VOLUNTEERS AB Every year since its introduction in 1991, there have been epidemics of cholera in Lima, Peru. Vaccination is one approach to the control of cholera. A pilot study was conducted to assess the safety and immunogenicity of a whole cell plus recombinant B subunit (WC/rBS) cholera vaccine in Lima, Peru. Five hundred and forty-one volunteers aged 2-65 years received two doses two weeks apart of WC/rBS vaccine or Escherichia coli K12 placebo administered in bicarbonate buffered water. Symptoms were monitored on all subjects and blood was collected from 102 persons before the first dose and two weeks after the second dose. Mild post-vaccination gastrointestinal symptoms were reported with equal frequency for both the vaccine and placebo recipients. Among 51 vaccinees, 49% had a twofold or greater increase in serum vibriocidal titers (GMT = 78, range <1:10 to 1:5120); and 92% and 82% developed a twofold or greater serum anti-cholera toxin IgG and IgA response, respectively. Persons with elevated prevaccination vibriocidal titers had a decreased response to the WC/rBS. Age and blood group did not affect the immune response. The WC/rBS vaccine was safe and immunogenic in a group of native Peruvians. C1 LIMA DETACHMENT,NAVAL MED RES INST,LIMA,PERU. WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC. GOTHENBURG UNIV,GOTHENBURG,SWEDEN. RP BEGUE, RE (reprint author), UNIV PERUANA CAYETANO HEREDIA,LIMA,PERU. NR 18 TC 16 Z9 16 U1 0 U2 4 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA LINACRE HOUSE JORDAN HILL, OXFORD, OXON, ENGLAND OX2 8DP SN 0264-410X J9 VACCINE JI Vaccine PD MAY PY 1995 VL 13 IS 7 BP 691 EP 694 DI 10.1016/0264-410X(94)00056-S PG 4 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA RG404 UT WOS:A1995RG40400012 PM 7668039 ER PT J AU EICEMAN, GA WANG, YF GARCIAGONZALEZ, L HARDEN, CS SHOFF, DB AF EICEMAN, GA WANG, YF GARCIAGONZALEZ, L HARDEN, CS SHOFF, DB TI ENHANCED SELECTIVITY IN ION MOBILITY SPECTROMETRY ANALYSIS OF COMPLEX-MIXTURES BY ALTERNATE REAGENT GAS CHEMISTRY SO ANALYTICA CHIMICA ACTA LA English DT Article DE MASS SPECTROMETRY; VOLATILE ORGANIC COMPOUNDS; ORGANOPHOSPHORUS COMPOUNDS ID PLASMA CHROMATOGRAPH AB Ion mobility spectrometry (IMS) analysis of a complex mixture of volatile organic compounds (VOCs) and organophosphorus compounds (OPCs) at vapor levels of 10-40 mg/m(3) produced mobility spectra with broad profiles illustrating limitations of ion mobility spectrometry (IMS) for screening such mixtures. Preseparation of this mixture with a gas chromatograph inlet to an ion mobility spectrometer enhanced analytical selectivity although OPC detection was complicated by co-elution with other VOCs. Water reagent gas in the ion source of the ion mobility spectrometer yielded 46 gas chromatographic peaks in a mixture of 45 VOCs and 19 OPCs. Co-elution of two materials was observed in eight of the chromatographic peaks and co-elution of three materials occurred in four instances. Further selectivity was gained using reagent gases of elevated proton affinity in the ion source. Reagent gas chemistry for acetone and dimethylsulfoxide reduced the number of GC peaks to 26 and 20, respectively. Moreover, spectral integrity and quantitative response for OPCs were retained at 50 to 1000 pg levels with these reagent gases. For OPCs, analyte ions were shown to be of the type M(2)H(+) under these conditions of analysis and the mobilities of the product ions were independent of reagent gas. Reduced mobility values were assigned to OPC spectra using a well-characterized OPC ion as the reference. Spectral profiles and reduced mobilities suggested that the OPC product ions were not clustered with reagent gas molecules at 100 degrees C. C1 USA,EDGEWOOD RES & DEV ENGN CTR,RES & TECHNOL DIRECTORATE,ABERDEEN PROVING GROUND,MD 21010. NEW MEXICO STATE UNIV,DEPT CHEM,LAS CRUCES,NM 88003. NR 25 TC 48 Z9 50 U1 5 U2 20 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0003-2670 J9 ANAL CHIM ACTA JI Anal. Chim. Acta PD APR 28 PY 1995 VL 306 IS 1 BP 21 EP 33 DI 10.1016/0003-2670(94)00668-C PG 13 WC Chemistry, Analytical SC Chemistry GA QW826 UT WOS:A1995QW82600003 ER PT J AU WILSON, RG PEARTON, SJ ABERNATHY, CR ZAVADA, JM AF WILSON, RG PEARTON, SJ ABERNATHY, CR ZAVADA, JM TI THERMAL-STABILITY OF IMPLANTED DOPANTS IN GAN SO APPLIED PHYSICS LETTERS LA English DT Article ID MOLECULAR-BEAM EPITAXY; ELECTRON-MOBILITY; GALLIUM NITRIDE; ZINCBLENDE GAN; RESONANCE; GROWTH; FILMS; GAAS C1 UNIV FLORIDA, GAINESVILLE, FL 32611 USA. USA, RES OFF, RES TRIANGLE PK, NC 27709 USA. RP HUGHES RES LABS, MALIBU, CA 90265 USA. NR 29 TC 59 Z9 59 U1 1 U2 3 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD APR 24 PY 1995 VL 66 IS 17 BP 2238 EP 2240 DI 10.1063/1.113178 PG 3 WC Physics, Applied SC Physics GA QU406 UT WOS:A1995QU40600030 ER PT J AU BROWN, ND BUTLER, DA LENAVITT, JA GORDON, RK CHIANG, PK AF BROWN, ND BUTLER, DA LENAVITT, JA GORDON, RK CHIANG, PK TI THYMOPENTIN (TP-5) ANALOGS WHICH PROTECT AGAINST ANATOXM-A (ANTX) INDUCED GUINEA-PIG ILEUM CONTRACTION SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT APPL BIOCHEM,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 24 PY 1995 VL 9 IS 6 BP A1373 EP A1373 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QV274 UT WOS:A1995QV27400771 ER PT J AU BRUGH, SA GORDON, RK AF BRUGH, SA GORDON, RK TI CHARACTERIZATION OF RICIN TOXICITY IN A549 CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 24 PY 1995 VL 9 IS 6 BP A1313 EP A1313 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QV274 UT WOS:A1995QV27400429 ER PT J AU CHIANG, PK LENAVITT, JA BUTLER, DL GORDON, RK AF CHIANG, PK LENAVITT, JA BUTLER, DL GORDON, RK TI ADENOSINE RECEPTOR (ADOR) LIGANDS AS MODULATORS OF CHOLINERGIC INDUCED ILEUM CONTRACTION SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT APPL BIOCHEM,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 24 PY 1995 VL 9 IS 6 BP A1371 EP A1371 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QV274 UT WOS:A1995QV27400761 ER PT J AU GORDON, RK PANKASKIE, MC HERSHFIELD, MS BRUGH, SA LANE, JR BURKE, DS MAYERS, DL CHIANG, PK AF GORDON, RK PANKASKIE, MC HERSHFIELD, MS BRUGH, SA LANE, JR BURKE, DS MAYERS, DL CHIANG, PK TI POSSIBLE MECHANISMS FOR THE ANTI-HIV ACTIVITY OF 3-DEAZA-ADENOSINE (DZA) ANALOGS SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV NEBRASKA,MED CTR,OMAHA,NE 68105. DUKE UNIV,MED CTR,DURHAM,NC 27710. SRA TECHNOL,ROCKVILLE,MD. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 24 PY 1995 VL 9 IS 6 BP A1279 EP A1279 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QV274 UT WOS:A1995QV27400224 ER PT J AU LEADER, H WOLFE, AD CHIANG, PK AF LEADER, H WOLFE, AD CHIANG, PK TI CHOLINESTERASE INHIBITION BY BINARY PRODRUGS COMPOSED OF PYRIDOSTIGMINE AND APROPHEN SUBSTITUENTS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT APPL BIOCHEM,DIV BIOCHEM,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 24 PY 1995 VL 9 IS 6 BP A1444 EP A1444 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QV274 UT WOS:A1995QV27401181 ER PT J AU MILLARD, CB LOCKRIDGE, O BROOMFIELD, CA AF MILLARD, CB LOCKRIDGE, O BROOMFIELD, CA TI BUTYRYLCHOLINESTERASE G117H, BUT NOT G117K, REACTIVATES SPONTANEOUSLY AFTER INHIBITION WITH NERVE AGENTS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. UNIV NEBRASKA,MED CTR,EPPLEY CANC INST,OMAHA,NE 68198. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 24 PY 1995 VL 9 IS 6 BP A1434 EP A1434 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QV274 UT WOS:A1995QV27401122 ER PT J AU RAY, P LIN, CP AF RAY, P LIN, CP TI MECHANISM OF MASTOPARAN EFFECTS ON ACETYLCHOLINE-RELEASE AND BOTULINUM TOXICITY IN PC12 CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 24 PY 1995 VL 9 IS 6 BP A1378 EP A1378 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QV274 UT WOS:A1995QV27400800 ER PT J AU RAY, R MAJERUS, BJ BROOMFIELD, CA AF RAY, R MAJERUS, BJ BROOMFIELD, CA TI A CALCIUM-MEDIATED MECHANISM OF MEMBRANE FLUIDITY ALTERATION DUE TO SULFUR MUSTARD IN CULTURED NORMAL HUMAN EPIDERMAL-KERATINOCYTES (NHEK) SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 24 PY 1995 VL 9 IS 6 BP A1375 EP A1375 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QV274 UT WOS:A1995QV27400783 ER PT J AU SAXENA, A HUR, R DOCTOR, BP AF SAXENA, A HUR, R DOCTOR, BP TI MECHANISM OF INHIBITION OF ACETYLCHOLINESTERASE BY MONOCLONAL-ANTIBODIES SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 24 PY 1995 VL 9 IS 6 BP A1483 EP A1483 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QV274 UT WOS:A1995QV27401403 ER PT J AU WOLFE, AD SAXENA, A LEADER, H CHIANG, PK AF WOLFE, AD SAXENA, A LEADER, H CHIANG, PK TI ACETYLCHOLINESTERASE INHIBITION BY ANALOGS OF PYRIDOSTIGMINE IN THE ABSENCE AND PRESENCE OF THE MONOCLONAL-ANTIBODY AE-2 SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 24 PY 1995 VL 9 IS 6 BP A1444 EP A1444 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QV274 UT WOS:A1995QV27401179 ER PT J AU ROSEN, LN DURAND, D WESTHUIS, DJ TEITELBAUM, JM AF ROSEN, LN DURAND, D WESTHUIS, DJ TEITELBAUM, JM TI MARITAL ADJUSTMENT OF ARMY SPOUSES ONE-YEAR AFTER OPERATION DESERT-STORM SO JOURNAL OF APPLIED SOCIAL PSYCHOLOGY LA English DT Article ID ATTACHMENT; SEPARATION AB One year after Operation Desert Storm, marital adjustment was studied among 773 Army spouses married to soldiers who had been deployed. Interviews with some spouses and soldiers, conducted during site visits to a sample of installations, led to the identification of 19 marital adjustment events. Questions regarding these events were included in a mailed questionnaire that was sent to a sample of Army spouses. A factor analysis of the 19 events produced five factors: (a) Distance, (b) Closeness, (c) Role sharing, (d) Independent Spouse, (e) Dependent Spouse/Withdrawn Soldier. Predictors of factor scores were examined through multiple regression analysis. Predictors of factor scores included stress, prior marital problems, social support, and emotional well-being. Most spouses adjusted well to the deployment. Adjustment patterns are discussed in light of previous literature on war separation and attachment theory. RP ROSEN, LN (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,SGRD UWI A,WASHINGTON,DC 20307, USA. NR 33 TC 8 Z9 8 U1 0 U2 1 PU V H WINSTON & SONS INC PI SILVER SPRING PA 7961 EASTERN AVE, SILVER SPRING, MD 20910 SN 0021-9029 J9 J APPL SOC PSYCHOL JI J. Appl. Soc. Psychol. PD APR 16 PY 1995 VL 25 IS 8 BP 677 EP 692 DI 10.1111/j.1559-1816.1995.tb01768.x PG 16 WC Psychology, Social SC Psychology GA QQ893 UT WOS:A1995QQ89300002 ER PT J AU COSTER, TS KILLEEN, KP WALDOR, MK BEATTIE, DT SPRIGGS, DR KENNER, JR TROFA, A SADOFF, JC MEKALANOS, JJ TAYLOR, DN AF COSTER, TS KILLEEN, KP WALDOR, MK BEATTIE, DT SPRIGGS, DR KENNER, JR TROFA, A SADOFF, JC MEKALANOS, JJ TAYLOR, DN TI SAFETY, IMMUNOGENICITY, AND EFFICACY OF LIVE ATTENUATED VIBRIO-CHOLERAE O139 VACCINE PROTOTYPE SO LANCET LA English DT Article ID BANGLADESH; RESPONSES; NON-01; SYSTEM AB New vaccines are needed to prevent cholera caused by Vibrio cholerae O139. Attenuated V cholerae O139 vaccines were made by deleting multiple copies of the cholera-toxin genetic element from two virulent strains of the organism, MO10 and Al4456. The deletion mutants were further modified by insertion of a construct that encoded the B subunit of cholera toxin, thus generating strains Bengal-3 and VRI-16, A stable spontaneous nonmotile derivative of Bengal-3 was isolated end designated Bengal-15; VRI-16 is naturally non-motile. Bengal-3, Bengal-15, and VRI-16 were evaluated as oral single-dose cholera vaccine candidates in 4 volunteers each, and MO10 was given to 3 volunteers, 1 of 4 volunteers who received Bengal-3 and all 3 who received MO10 had diarrhoea, VRI-16 caused no significant symptoms but was not immunogenic. Bengal-15 produced few symptoms and was nearly as immunogenic as MO10. Subsequently, Bengal-15 was given to 10 volunteers at a dose of 10(6) colony-forming units. No volunteers had diarrhoea, and other subjective symptoms were as common in vaccinees as in 3 buffer recipients. 1 month after vaccination, 7 vaccinees, the 3 buffer recipients, and 3 unimmunised subjects were challenged with 5x10(6) colony-forming units of V cholerae O139. 5 of 6 controls had cholera-like diarrhoea, By contrast, 1 of 7 vaccinees had diarrhoea, which was mild and had a long incubation period. Vaccine protective efficacy was 83%. Our results indicate the Bengal-15 is a safe live attenuated vaccine candidate for cholera caused by the O139 serogroup. C1 INST VIRUS RES,CAMBRIDGE,MA. HARVARD UNIV,SCH MED,DEPT MICROBIOL & MOLEC GENET,BOSTON,MA. WALTER REED ARMY INST RES,DEPT CLIN TRIALS,DIV COMMUN DIS & IMMUNOL,WASHINGTON,DC. RP COSTER, TS (reprint author), USA,MED RES INST INFECT DIS,DIV MED,CLIN STUDIES BRANCH,FREDERICK,MD 21702, USA. NR 21 TC 106 Z9 109 U1 0 U2 1 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0099-5355 J9 LANCET JI Lancet PD APR 15 PY 1995 VL 345 IS 8955 BP 949 EP 952 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA QT919 UT WOS:A1995QT91900008 PM 7715293 ER PT J AU BARTH, J AF BARTH, J TI THE KING OF CASH - THE INSIDE STORY OF TISCH,LAURENCE - WINANS,C SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD,LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 15 PY 1995 VL 120 IS 7 BP 87 EP 87 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA QT087 UT WOS:A1995QT08700089 ER PT J AU MAZUMDER, MM CHEN, G CHANG, RK GILLESPIE, JB AF MAZUMDER, MM CHEN, G CHANG, RK GILLESPIE, JB TI WAVELENGTH SHIFTS OF DYE LASING IN MICRODROPLETS - EFFECT OF ABSORPTION CHANGE SO OPTICS LETTERS LA English DT Article ID EMISSION AB With addition of an absorber to dye-doped microdroplets, an absorption-dependent blue shift in the lasing spectra has been observed. The better the spectral overlap between the absorption and the fluorescence spectra of the dye, the larger the blue shift. The experimental observations are explained by a simple model of dye lasing in an optical cavity that includes losses because of the absorber and radiation leakage. C1 YALE UNIV,CTR LASER DIAGNOST,NEW HAVEN,CT 06520. USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP MAZUMDER, MM (reprint author), YALE UNIV,DEPT APPL PHYS,NEW HAVEN,CT 06520, USA. NR 11 TC 23 Z9 23 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD APR 15 PY 1995 VL 20 IS 8 BP 878 EP 880 DI 10.1364/OL.20.000878 PG 3 WC Optics SC Optics GA QT452 UT WOS:A1995QT45200025 PM 19859360 ER PT J AU SIRENKO, YM STROSCIO, MA KIM, KW MITIN, V AF SIRENKO, YM STROSCIO, MA KIM, KW MITIN, V TI BALLISTIC PROPAGATION OF INTERFACE OPTICAL PHONONS SO PHYSICAL REVIEW B LA English DT Article ID ELECTRON-HOLE TRANSPORT; LO PHONONS; GAAS; HETEROSTRUCTURES; RAMAN; DIMENSIONALITY; SCATTERING; GENERATION; STATISTICS; GAAS/ALAS C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. WAYNE STATE UNIV,DEPT ELECT & COMP ENGN,DETROIT,MI 48202. RP SIRENKO, YM (reprint author), N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695, USA. NR 27 TC 0 Z9 0 U1 0 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD APR 15 PY 1995 VL 51 IS 15 BP 9863 EP 9866 DI 10.1103/PhysRevB.51.9863 PG 4 WC Physics, Condensed Matter SC Physics GA QV237 UT WOS:A1995QV23700054 ER PT J AU BANNOV, N ARISTOV, V MITIN, V STROSCIO, MA AF BANNOV, N ARISTOV, V MITIN, V STROSCIO, MA TI ELECTRON RELAXATION-TIMES DUE TO THE DEFORMATION-POTENTIAL INTERACTION OF ELECTRONS WITH CONFINED ACOUSTIC PHONONS IN A FREESTANDING QUANTUM-WELL SO PHYSICAL REVIEW B LA English DT Article ID BRILLOUIN-SCATTERING; 2 INTERFACES; WIRES; MODES; SYSTEMS; WAVES; FABRICATION; DYNAMICS; FILMS C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP BANNOV, N (reprint author), WAYNE STATE UNIV,DEPT ELECT & COMP ENGN,DETROIT,MI 48202, USA. NR 42 TC 134 Z9 134 U1 1 U2 9 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD APR 15 PY 1995 VL 51 IS 15 BP 9930 EP 9942 DI 10.1103/PhysRevB.51.9930 PG 13 WC Physics, Condensed Matter SC Physics GA QV237 UT WOS:A1995QV23700064 ER PT J AU PIERSON, SW REINECKE, TL RUDIN, S AF PIERSON, SW REINECKE, TL RUDIN, S TI NEUTRAL-DONOR-BOUND COLLECTIVE EXCITATIONS IN THE BULK AND IN QUANTUM-WELLS SO PHYSICAL REVIEW B LA English DT Article ID ELECTRON-PHONON INTERACTION; POLAR SEMICONDUCTORS; IMPURITIES C1 USA,RES LAB,FT MONMOUTH,NJ 07703. RP PIERSON, SW (reprint author), USN,RES LAB,WASHINGTON,DC 20375, USA. NR 12 TC 3 Z9 3 U1 0 U2 0 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD APR 15 PY 1995 VL 51 IS 16 BP 10817 EP 10824 DI 10.1103/PhysRevB.51.10817 PG 8 WC Physics, Condensed Matter SC Physics GA QW284 UT WOS:A1995QW28400057 ER PT J AU BAHDER, TB AF BAHDER, TB TI CONVERSE PIEZOELECTRIC EFFECT IN [111] STRAINED-LAYER HETEROSTRUCTURES SO PHYSICAL REVIEW B LA English DT Article ID OPTICAL-PROPERTIES; QUANTUM-WELLS; HYDROSTATIC PRESSURE; ELECTRONIC-STRUCTURE; ZINCBLENDE CRYSTALS; SUPERLATTICES; FIELDS; GROWTH RP USA, RES LAB, 2800 POWDER MILL RD, ADELPHI, MD 20783 USA. NR 34 TC 20 Z9 20 U1 1 U2 3 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9950 EI 2469-9969 J9 PHYS REV B JI Phys. Rev. B PD APR 15 PY 1995 VL 51 IS 16 BP 10892 EP 10896 DI 10.1103/PhysRevB.51.10892 PG 5 WC Physics, Condensed Matter SC Physics GA QW284 UT WOS:A1995QW28400067 ER PT J AU DUDLEY, M WANG, SP HUANG, W CARTER, CH TSVETKOV, VF FAZI, C AF DUDLEY, M WANG, SP HUANG, W CARTER, CH TSVETKOV, VF FAZI, C TI WHITE-BEAM SYNCHROTRON TOPOGRAPHIC STUDIES OF DEFECTS IN 6H-SIC SINGLE-CRYSTALS SO JOURNAL OF PHYSICS D-APPLIED PHYSICS LA English DT Article ID SILICON-CARBIDE AB Synchrotron white-beam x-ray topography studies, in conjunction with Nomarski optical microscopy, have been carried out on 6H-SiC single crystals grown by the sublimation physical vapour transport technique. Two kinds of dislocations were observed using topography: dislocations exhibiting bimodal images of various widths and with line directions approximately parallel to the [0001] axis and dislocations confined to the basal plane, which appear to have emanated from the former dislocations. The larger bimodal image width dislocations were found to have hollow cores, known as 'micropipes'. Detailed contrast analysis of topographic images obtained in transmission and back-reflection geometries establishes that 'micropipes' are Frank-type hollow-core screw dislocations with Burgers vectors typically equal to 3-7 times the c lattice parameter. X-ray topography also revealed many line defects approximately parallel to the [0001] axis that were determined to be screw dislocations with Burgers vectors equal to the c lattice parameter and there were no discernible 'micropipes' associated with these latter screw dislocations. C1 CREE RES INC,DURHAM,NC 27713. USA,RES LAB,ADELPHI,MD 20783. RP DUDLEY, M (reprint author), SUNY STONY BROOK,DEPT MAT SCI & ENGN,STONY BROOK,NY 11794, USA. NR 16 TC 79 Z9 81 U1 0 U2 5 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0022-3727 J9 J PHYS D APPL PHYS JI J. Phys. D-Appl. Phys. PD APR 14 PY 1995 VL 28 IS 4A SI SI BP A63 EP A68 DI 10.1088/0022-3727/28/4A/012 PG 6 WC Physics, Applied SC Physics GA QX640 UT WOS:A1995QX64000014 ER PT J AU DUDLEY, M HUANG, W WANG, S POWELL, JA NEUDECK, P FAZI, C AF DUDLEY, M HUANG, W WANG, S POWELL, JA NEUDECK, P FAZI, C TI WHITE-BEAM SYNCHROTRON TOPOGRAPHIC ANALYSIS OF MULTI-POLYTYPE SIC DEVICE CONFIGURATIONS SO JOURNAL OF PHYSICS D-APPLIED PHYSICS LA English DT Article ID CHEMICAL VAPOR-DEPOSITION; 6H; FILMS AB White-beam synchrotron topographic analysis of SiC device configurations of various polytypes has been carried out. The devices, p-n junctions of area 1 mm(2), were fabricated via chemical vapour deposition epilayer growth of nominally 3C- or 6H-SiC, on 6H-SiC substrates grown by either the physical vapour transport or the Lely technique. Detailed analysis of diffracted intensities from the different device areas in grazing reflection geometry, using a specially developed computer program, is presented. Depth profiling carried out using variable penetration depth, grazing-incidence geometries reveals both the polytype configuration and the defect structure as a function of depth in these multi-polytype epilayers. C1 NASA,LEWIS RES CTR,CLEVELAND,OH 44135. USA,RES LAB,SLCHD NW RF,ADELPHI,MD 20783. RP DUDLEY, M (reprint author), SUNY STONY BROOK,DEPT MAT SCI & ENGN,STONY BROOK,NY 11794, USA. NR 17 TC 15 Z9 15 U1 0 U2 1 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0022-3727 J9 J PHYS D APPL PHYS JI J. Phys. D-Appl. Phys. PD APR 14 PY 1995 VL 28 IS 4A SI SI BP A56 EP A62 DI 10.1088/0022-3727/28/4A/011 PG 7 WC Physics, Applied SC Physics GA QX640 UT WOS:A1995QX64000013 ER PT J AU DOEBLER, JA WILTSHIRE, ND MAYER, TW ESTEP, JE MOELLER, RB TRAUB, RK BROOMFIELD, CA CALAMAIO, CA THOMPSON, WL PITT, ML AF DOEBLER, JA WILTSHIRE, ND MAYER, TW ESTEP, JE MOELLER, RB TRAUB, RK BROOMFIELD, CA CALAMAIO, CA THOMPSON, WL PITT, ML TI THE DISTRIBUTION OF [I-125] RICIN IN MICE FOLLOWING AEROSOL INHALATION EXPOSURE SO TOXICOLOGY LA English DT Article DE RICIN (RCA 60); AEROSOL INHALATION; ORGAN DISTRIBUTION; [I-125] RICIN ID LECTINS ABRIN; RAT-LIVER; RICIN; TOXICITY; CATABOLISM; MECHANISM; INTESTINE; PROTEINS; CELLS AB Studies were conducted to examine the uptake and redistribution of [I-125]ricin from the lungs of mice following nose-only aerosol inhalation exposure. Radiolabelled contents were measured in lung and various extra-pulmonary tissues 15 min through 30 h following 10 min aerosol exposures, Pharmacokinetic analyses were performed on whole-organ data obtained for lungs, stomach, liver and spleen. Radioactivity within the lungs, maximal at 15 min post-exposure, was eliminated in a biexponential fashion with a long beta half-life (similar to 40 h). Large amounts of radiolabel were also found within the gastrointestinal tract. Radiolabel within the stomach exhibited an absorption phase and two-compartment elimination, Radiolabel content of many other tissues, including known accumulation sites for intravenously administered toxin, was significantly (p < 0.05) increased (relative to 15 min post-exposure) in association with tile early elimination of radiolabel from the lungs, but levels in these tissues were very low and did not increase after 4 h post-exposure, The only exception was our sample of trachea, which showed delayed elevations in radiolabel (peak at 24 h); this pattern was attributable to the contained thyroid (not removed at necropsy) and its trapping of free [I-125] released upon tissue [I-125]ricin degradation. The overall data indicate that ricin administered by aerosol inhalation is delivered to both respiratory and gastrointestinal tracts; however, it is not extensively transported from either tract to other potential target sites, Ricin delivered to the lungs is primarily sequestered within the lungs until degradation, Only small amounts of ricin delivered to the gastrointestinal tract are absorbed into the circulation. C1 USA,MED RES INST CHEM DEF,DIV VET MED & LAB RESOURCES,ABERDEEN PROVING GROUND,MD 21010. USA,MED RES INST INFECT DIS,DIV APPL RES,FT DETRICK,MD 21702. USA,MED RES INST CHEM DEF,DIV PHARMACOL,ABERDEEN PROVING GROUND,MD 21010. USA,MED RES INST INFECT DIS,DIV TOXICOL,FT DETRICK,MD 21702. RP DOEBLER, JA (reprint author), USA,MED RES INST CHEM DEF,DIV PATHOPHYSIOL,ABERDEEN PROVING GROUND,MD 21010, USA. NR 19 TC 30 Z9 33 U1 0 U2 4 PU ELSEVIER SCI PUBL IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD APR 12 PY 1995 VL 98 IS 1-3 BP 137 EP 149 DI 10.1016/0300-483X(94)02978-4 PG 13 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA QX943 UT WOS:A1995QX94300015 PM 7740542 ER PT J AU KEWITSCH, AS TOWE, TW SALAMO, GJ YARIV, A ZHANG, M SEGEV, M SHARP, EJ NEURGAONKAR, RR AF KEWITSCH, AS TOWE, TW SALAMO, GJ YARIV, A ZHANG, M SEGEV, M SHARP, EJ NEURGAONKAR, RR TI OPTICALLY INDUCED QUASI-PHASE MATCHING IN STRONTIUM BARIUM NIOBATE SO APPLIED PHYSICS LETTERS LA English DT Article C1 UNIV ARKANSAS,DEPT PHYS,FAYETTEVILLE,AR 72701. PRINCETON UNIV,DEPT ELECT ENGN,PRINCETON,NJ 08544. USA,RES LAB,FT BELVOIR,VA 22060. ROCKWELL INT CORP,CTR SCI,THOUSAND OAKS,CA 91360. RP KEWITSCH, AS (reprint author), CALTECH,DEPT APPL PHYS,PASADENA,CA 91125, USA. NR 10 TC 14 Z9 14 U1 0 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD APR 10 PY 1995 VL 66 IS 15 BP 1865 EP 1867 DI 10.1063/1.113303 PG 3 WC Physics, Applied SC Physics GA QR189 UT WOS:A1995QR18900003 ER PT J AU BULUSU, S DAMAVARAPU, R AUTERA, JR BEHRENS, R MINIER, LM VILLANUEVA, J JAYASURIYA, K AXENROD, T AF BULUSU, S DAMAVARAPU, R AUTERA, JR BEHRENS, R MINIER, LM VILLANUEVA, J JAYASURIYA, K AXENROD, T TI THERMAL REARRANGEMENT OF 1,4-DINITROIMIDAZOLE TO 2,4-DINITROIMIDAZOLE - CHARACTERIZATION AND INVESTIGATION OF THE MECHANISM BY MASS-SPECTROMETRY AND ISOTOPE LABELING SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID OCTAHYDRO-1,3,5,7-TETRANITRO-1,3,5,7-TETRAZOCINE HMX; PYROLYSIS; MIGRATION; PRODUCTS AB The thermal rearrangement of 1,4-dinitroimidazole to 2,4-dinitroimidazole has been investigated by differential scanning calorimetry and mass spectrometry techniques. When mixtures of independently prepared deuterium and N-15-labeled samples of the 1,4-isomer were subjected to thermal rearrangement, the resulting 2,4-dinitroimidazole failed to show isotope-scrambled molecular ions in its mass spectrum, suggesting that the reaction was intramolecular in nature. This was interpreted to mean that the mechanism was of the (1,5)-sigmatropic type rearrangement. Extensive NMR measurements were used to obtain unequivocal evidence for the identity of the assumed structures of the isomeric dinitroimidazoles. Two byproducts (4-nitroimidazole and a trinitroimidazole), formed during the rearrangement reaction, have also been identified. Plausible mechanisms for their formation are discussed. C1 SANDIA NATL LABS,COMBUST RES FACIL,LIVERMORE,CA 94551. USA,ARMAMENTS RES,GEO CTR INC,PICATINNY ARSENAL,NJ 07806. CUNY CITY COLL,DEPT CHEM,NEW YORK,NY 10031. RP BULUSU, S (reprint author), USA,ARMAMENTS RES,CTR DEV & ENGN,DIV ENERGET MAT,PICATINNY ARSENAL,NJ 07806, USA. NR 17 TC 59 Z9 64 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD APR 6 PY 1995 VL 99 IS 14 BP 5009 EP 5015 DI 10.1021/j100014a022 PG 7 WC Chemistry, Physical SC Chemistry GA QR228 UT WOS:A1995QR22800022 ER PT J AU RICE, BM ADAMS, GF PAGE, M THOMPSON, DL AF RICE, BM ADAMS, GF PAGE, M THOMPSON, DL TI CLASSICAL DYNAMICS SIMULATIONS OF UNIMOLECULAR DECOMPOSITION OF CH2NNO2 - HONO ELIMINATION VS N-N BOND SCISSION SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID ISOMERIZATION; DISSOCIATION; MODEL AB Classical dynamics simulations of the-unimolecular decomposition of CH2NNO2 have been performed. A potential energy function was developed based on MCSCF and MRCI calculations of Mowrey, Page, Adams, and Lengsfield (J. Chem. Phys. 1990, 93, 1857). Rates and mechanisms for the primary decomposition channels of CH2NNO2 are presented. The two primary decomposition pathways are (I) N-N bond scission to form H2CN and NO2 and (II) concerted dissociation via a five-center transition state to eliminate HONO + HCN. The classical barrier heights differ by 2 kcal/mol. Reactions I and II are first-order decay processes and are well-behaved with increasing energy. At low energies I is the major decomposition pathway, but at high energies II becomes equally probable. Product energy distributions for I are unremarkable, with the relative translational and rotational distributions peaked near zero; however, distributions for II show interesting behavior. The trajectories resulting in II that do not experience secondary HONO decomposition have a translational energy distribution that is shifted significantly away from zero, as expected for reactions with large back reaction barriers. The trajectories resulting in II that undergo secondary HONO decomposition, however, have a translational energy distribution that is similar to the distributions in I, indicating very little translational energy excitation upon formation. Rotational energy distributions for II are peaked near zero, regardless of whether: HONO decomposes. Most of the available product energy for II goes into vibration. Our results, calculated under microcanonical conditions in which energy is partitioned in a statistical manner among the internal modes, are not consistent with the molecular beam measurements of RDX, in which CH2NNO2 is a primary decomposition product that subsequently decomposes only through concerted molecular eliminations. C1 N DAKOTA STATE UNIV,DEPT CHEM,FARGO,ND 58105. OKLAHOMA STATE UNIV,DEPT CHEM,STILLWATER,OK 74078. RP RICE, BM (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 19 TC 26 Z9 26 U1 1 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD APR 6 PY 1995 VL 99 IS 14 BP 5016 EP 5028 DI 10.1021/j100014a023 PG 13 WC Chemistry, Physical SC Chemistry GA QR228 UT WOS:A1995QR22800023 ER PT J AU BROWN, AE BURKE, DS AF BROWN, AE BURKE, DS TI COST OF HIV TESTING IN THE US ARMY SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter ID STATES RP BROWN, AE (reprint author), WALTER REED ARMY INST RES,ROCKVILLE,MD 20850, USA. NR 4 TC 5 Z9 5 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD APR 6 PY 1995 VL 332 IS 14 BP 963 EP 963 DI 10.1056/NEJM199504063321419 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA QP893 UT WOS:A1995QP89300030 PM 7877666 ER PT J AU LEAVITT, RP BRADSHAW, JL PHAM, JT AF LEAVITT, RP BRADSHAW, JL PHAM, JT TI SUPERLATTICE-EQUIVALENT (IN,GA)AS/(IN,AL)AS QUANTUM-WELLS WITH LARGE STARK SHIFTS IN THE 1.3-MU-M SPECTRAL REGION SO APPLIED PHYSICS LETTERS LA English DT Article ID ELECTRIC-FIELD; ELECTROABSORPTION RP LEAVITT, RP (reprint author), USA,RES LAB,ADELPHI,MD 20783, USA. RI Bradshaw, John/E-8330-2011 NR 10 TC 4 Z9 4 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD APR 3 PY 1995 VL 66 IS 14 BP 1803 EP 1805 DI 10.1063/1.113327 PG 3 WC Physics, Applied SC Physics GA QQ377 UT WOS:A1995QQ37700031 ER PT J AU KAPLAN, DL AF KAPLAN, DL TI PROTEIN-BASED POLYMERS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RES & DEV CTR,DIV BIOTECHNOL,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 31 EP PMSE PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP233 UT WOS:A1995QP23301557 ER PT J AU VALDES, JJ TAYLOR, RB CHAMBERS, JP AF VALDES, JJ TAYLOR, RB CHAMBERS, JP TI STRATEGIES FOR ARTIFICIAL BIOLOGICAL RECOGNITION - PHAGE DISPLAYED AND OTHER NOVEL PEPTIDES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,EDGEWOOD RD&E CTR,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 32 EP AGRO PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP232 UT WOS:A1995QP23200182 ER PT J AU HOYT, RW AF HOYT, RW TI ENERGY AND WATER REQUIREMENTS FOR WORK IN MOUNTAINOUS TERRAIN SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,DIV ALTITUDE PHYSIOL & MED,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 33 EP AGFD PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP232 UT WOS:A1995QP23200033 ER PT J AU LIEBERMAN, HR AF LIEBERMAN, HR TI PERFORMANCE ENHANCING FOOD COMPONENTS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,DIV MIL NUTR,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 34 EP AGFD PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP232 UT WOS:A1995QP23200034 ER PT J AU TAUB, IA LEWIS, SF AF TAUB, IA LEWIS, SF TI COMPLEX CARBOHYDRATES AS A CONTROLLABLE ENERGY-SOURCE FOR EXTENDING PERFORMANCE SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 BOSTON UNIV,BOSTON,MA 02215. USA,NATICK RD&E CTR,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 36 EP AGFD PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP232 UT WOS:A1995QP23200036 ER PT J AU PRINCE, JT MCGRATH, KP DIGIROLAMO, C KAPLAN, DL AF PRINCE, JT MCGRATH, KP DIGIROLAMO, C KAPLAN, DL TI SYNTHETIC SPIDER DRAGLINE SILK SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,DIV BIOTECHNOL,CTR DEV & ENGN,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 53 EP PMSE PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP233 UT WOS:A1995QP23301579 ER PT J AU MENKING, DE GOODE, MT AF MENKING, DE GOODE, MT TI ANTIBODY-BASED BIOLOGICAL TOXIN DETECTION SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,EDGEWOOD RES,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 78 EP AGFD PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP232 UT WOS:A1995QP23200078 ER PT J AU STILES, BG KRAKAUER, T BONVENTRE, PF AF STILES, BG KRAKAUER, T BONVENTRE, PF TI EFFECTS OF TOXIC SHOCK SYNDROME TOXIN-1 AND A SITE-DIRECTED MUTANT, H135A, IN MICE SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. UNIV CINCINNATI,MED CTR,CINCINNATI,OH 45267. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 80 EP AGFD PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP232 UT WOS:A1995QP23200080 ER PT J AU YUE, CL DAVE, V KAPLAN, DL MCCARTHY, SP AF YUE, CL DAVE, V KAPLAN, DL MCCARTHY, SP TI ADVANCED MATERIALS FROM RENEWABLE RESOURCES - KONJAC PULLULAN BLENDS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV MASSACHUSETTS,DEPT PLAST ENGN,LOWELL,MA 01854. USA,CTR RES DEV & ENGN,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 81 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP233 UT WOS:A1995QP23301217 ER PT J AU GARTHWAITE, I POLI, M TOWERS, NR AF GARTHWAITE, I POLI, M TOWERS, NR TI COMPARISON OF IMMUNOASSAY, CELLULAR AND CLASSICAL MOUSE BIOASSAY METHODS FOR DETECTION OF THE NEUROTOXIC SHELLFISH TOXINS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 AGRES RUAKURA,HAMILTON,NEW ZEALAND. USA,FT DETRICK,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 89 EP BTEC PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP233 UT WOS:A1995QP23301968 ER PT J AU WINFREE, ML APPLAND, JP FILBERT, MG AF WINFREE, ML APPLAND, JP FILBERT, MG TI ZINC CHELATION FOR IN-VITRO PROTECTION AGAINST BOTULINUM TOXIN-INDUCED LOSS OF SYNAPTIC TRANSMISSION IN APLYSIA BUCCAL GANGLIA SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 92 EP AGFD PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP232 UT WOS:A1995QP23200092 ER PT J AU CROWSON, A AF CROWSON, A TI SMART MATERIALS BASED ON POLYMERIC SYSTEMS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,RES OFF,DIV MAT SCI,RES TRIANGLE PK,NC 27709. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 96 EP PMSE PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP233 UT WOS:A1995QP23301622 ER PT J AU ELDEFRAWI, M ELDEFRAWI, A EMANUEL, P VALDES, J ROGERS, K JOHNSON, E AF ELDEFRAWI, M ELDEFRAWI, A EMANUEL, P VALDES, J ROGERS, K JOHNSON, E TI IMMUNOSENSORS FOR DETECTION OF CHEMICAL-MIXTURES - ANTIBODY AFFINITIES, SELECTIVITIES AND CLONING SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPTL THERAP,BALTIMORE,MD 21201. USA,EDGEWOOD RD & EC,ABERDEEN PROVING GROUND,MD 21010. US EPA,ENVIRONM MONITORING SYST LAB,LAS VEGAS,NV 89193. USDA,WEED SCI LAB,BELTSVILLE,MD 20705. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 97 EP BTEC PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP233 UT WOS:A1995QP23301976 ER PT J AU ELDEFRAWI, M ZHAO, C ELDEFRAWI, A ANIS, N VALDES, J AF ELDEFRAWI, M ZHAO, C ELDEFRAWI, A ANIS, N VALDES, J TI A POTENTIOMETRIC BIOSENSOR FOR MONITORING PHOSPHORYLATION AND AGING OF CHOLINESTERASES AS BIOMARKERS OF EXPOSURE SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21201. USA,EDGEWOOD RDEC,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 108 EP AGRO PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP232 UT WOS:A1995QP23200258 ER PT J AU WHITE, WE DONOVAN, WH AF WHITE, WE DONOVAN, WH TI TRANSITION-STATE ANALOGS FOR MUSTARD SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 116 EP COMP PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP232 UT WOS:A1995QP23201877 ER PT J AU FAMINI, GR WILSON, LY CHESTER, NA STERLING, PA AF FAMINI, GR WILSON, LY CHESTER, NA STERLING, PA TI USING THEORETICAL DESCRIPTIONS IN STRUCTURE-ACTIVITY-RELATIONSHIPS - VALIDATING TOXICITY PREDICTIONS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. LA SIERRA UNIV,RIVERSIDE,CA 92515. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 130 EP AGRO PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP232 UT WOS:A1995QP23200278 ER PT J AU ZHANG, XY YAO, XT HE, MY DALTON, JT SHAMS, G LEI, L FELLER, DR HSU, FL MILLER, DD AF ZHANG, XY YAO, XT HE, MY DALTON, JT SHAMS, G LEI, L FELLER, DR HSU, FL MILLER, DD TI DESIGN, SYNTHESIS AND BIOLOGICAL-ACTIVITY OF CONFORMATIONALLY RESTRICTED NAPHTHALENE DERIVATIVES OF MEDETOMIDINE AS ALPHA(2)-ADRENERGIC AGONISTS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 OHIO STATE UNIV,COLL PHARM,DIV MED CHEM & PHARMACOL,COLUMBUS,OH 43210. UNIV TENNESSEE CTR HLTH SCI,COLL PHARM,DEPT PHARMACEUT SCI,MEMPHIS,TN 38163. USA,EDGEWOOD RES DEV ENGN CTR,SCRRD,RTC,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 154 EP MEDI PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP232 UT WOS:A1995QP23203347 ER PT J AU PRZESLAWSKI, RM HSU, FL ASHMAN, WP DALTON, JT MILLER, DD AF PRZESLAWSKI, RM HSU, FL ASHMAN, WP DALTON, JT MILLER, DD TI SYNTHESIS AND ALPHA-ADRENERGIC ACTIVITIES OF QUINOLINE AND QUINOXALINE ANALOGS OF MEDETOMIDINE SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. UNIV TENNESSEE CTR HLTH SCI,COLL PHARM,MEMPHIS,TN 38163. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 156 EP MEDI PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP232 UT WOS:A1995QP23203349 ER PT J AU FAMINI, GR WEI, S AF FAMINI, GR WEI, S TI VISUALIZATION OF ELECTRONIC-PROPERTIES OF MOLECULES IN CHEMICAL-REACTIONS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,EDGEWOOD RDE CTR,ABERDEEN PROVING GROUND,MD 21010. ST JOSEPHS UNIV,DEPT MATH & COMP SCI,PHILADELPHIA,PA 19131. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 174 EP COMP PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP232 UT WOS:A1995QP23201935 ER PT J AU LANZEROTTI, YD AF LANZEROTTI, YD TI POWER SPECTRAL CHARACTERIZATION OF TNT FRACTURE SURFACES USING ATOMIC-FORCE MICROSCOPY SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 AT&T BELL LABS,MURRAY HILL,NJ 07974. USA,ARDEC,RICATINNY ARSENAL,NJ 07806. NEW YORK CITY TECH COLL,BROOKLYN,NY 11201. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 192 EP PHYS PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP233 UT WOS:A1995QP23300945 ER PT J AU MAXWELL, DM CLARK, CR ZOEFFEL, LD ARROYO, CM LOWE, JR LIESKE, CN AF MAXWELL, DM CLARK, CR ZOEFFEL, LD ARROYO, CM LOWE, JR LIESKE, CN TI THERMODYNAMIC PARAMETERS IN ALBUMIN-CATALYZED CYANOLYSIS USING ELEMENTAL SULFUR SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,MRICD,ABERDEEN PROVING GROUND,MD 21010. PROGRAMMING CONSULTANTS,BRADDOCK HTS,MD 21714. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 226 EP MEDI PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP232 UT WOS:A1995QP23203419 ER PT J AU MUNAVALLI, S ROHRBAUGH, DK ROSSO, T ROSSMAN, DI ELLZY, MW FERGUSON, CP DURST, HD AF MUNAVALLI, S ROHRBAUGH, DK ROSSO, T ROSSMAN, DI ELLZY, MW FERGUSON, CP DURST, HD TI TRIFLUOROMETHYLTHIOCOPPER CATALYZED OXIRANE RING-OPENING SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 GEOCENTERS INC,FT WASHINGTON,MD 20774. USA,CTR EDGEWOOD RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 306 EP ORGN PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP233 UT WOS:A1995QP23300425 ER PT J AU WAGNER, GW BEAUDRY, WT WARD, JR AF WAGNER, GW BEAUDRY, WT WARD, JR TI CU(II)-DIAMINE COMPLEX-CATALYZED HYDROLYSIS OF PHOSPHATE TRIESTERS ADSORBED ON STRONG-BASE ION-EXCHANGE RESINS - P-31 NMR RELAXATION MEASUREMENTS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 GEOCENTERS INC,GUNPOWDER BRANCH,ABERDEEN PROVING GROUND,MD 21010. USA,R&T DIRECTORATE,ERDEC,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 449 EP INOR PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP232 UT WOS:A1995QP23203048 ER PT J AU OWENS, PM AF OWENS, PM TI REPORT ON A GENERAL-CHEMISTRY COURSE THAT FOCUSES ON MATERIALS SCIENCE, ENVIRONMENTAL SCIENCE, AND LIFE SCIENCES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 US MIL ACAD,DEPT CHEM,W POINT,NY 10996. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 471 EP CHED PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP232 UT WOS:A1995QP23201331 ER PT J AU MUNAVALLI, S SZAFRANIEC, LL BEAUDRY, WT ROHRBAUGH, DK ROSSMAN, DI ROSSO, T DURST, HD AF MUNAVALLI, S SZAFRANIEC, LL BEAUDRY, WT ROHRBAUGH, DK ROSSMAN, DI ROSSO, T DURST, HD TI NOVEL REACTIONS OF BIS (TRIFLUOROMETHYL) DISULFIDE AND TRIFLUOROMETHYLSULFENYL CHLORIDE WITH 1,3-DITHIANE SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 GEOCENTERS INC,FT WASHINGTON,MD 20774. USA,CTR EDGEWOOD RES DEV & ENGN,EDGEWOOD,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 2 PY 1995 VL 209 BP 493 EP ORGN PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA QP233 UT WOS:A1995QP23300611 ER PT J AU DOMS, RW EARL, PL MASCOLA, JR HOXIE, JA BRODER, CC ABEDON, ST AF DOMS, RW EARL, PL MASCOLA, JR HOXIE, JA BRODER, CC ABEDON, ST TI THE HUMORAL RESPONSE TO OLIGIOMERIC HIV-1 ENV PROTEIN SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Meeting Abstract C1 UNIV PENN,PHILADELPHIA,PA 19104. NIH,BETHESDA,MD 20892. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD APR 2 PY 1995 SU 21B BP 219 EP 219 PG 1 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA QT865 UT WOS:A1995QT86500742 ER PT J AU PESTANO, GA HOSFORD, K RILEY, J SPIRA, A MASCOLA, J GUYDEN, J HO, DD BOTO, WM AF PESTANO, GA HOSFORD, K RILEY, J SPIRA, A MASCOLA, J GUYDEN, J HO, DD BOTO, WM TI CONSERVATION OF ANTIGENIC SPECIFICITIES IN DIVERGENT V3 LOOP RESIDUES FROM HIV-1 SUBTYPE-A THROUGH SUBTYPE-F SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Meeting Abstract C1 CUNY CITY COLL,DEPT BIOL & CHEM,NEW YORK,NY 10031. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. AARON DIAMOND AIDS RES FDN,NEW YORK,NY 10016. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD APR 2 PY 1995 SU 21B BP 224 EP 224 PG 1 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA QT865 UT WOS:A1995QT86500762 ER PT J AU MCDONALD, RA MAYERS, DL CHUNG, RCY WAGNER, KF BIRX, D MICHAEL, NL AF MCDONALD, RA MAYERS, DL CHUNG, RCY WAGNER, KF BIRX, D MICHAEL, NL TI ENVELOPE SEQUENCE DIVERSITY OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 AND DISEASE PROGRESSION IN A LONGITUDINAL STUDIED COHORT SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,RV43 STUDY GRP,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD APR 2 PY 1995 SU 21B BP 240 EP 240 PG 1 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA QT865 UT WOS:A1995QT86500827 ER PT J AU MORGAN, JA AF MORGAN, JA TI CLINICAL PEARLS - UNILATERAL FACIAL SWELLING AND FEVER - ERYSIPELAS SO ACADEMIC EMERGENCY MEDICINE LA English DT Note DE CRYSIPELAS; CELLULITIS; GROUP A STREPTOCOCCUS C1 WILFORD HALL USAF MED CTR,DEPT EMERGENCY MED,LACKLAND AFB,TX. RP MORGAN, JA (reprint author), BROOKE ARMY MED CTR,JOINT MIL MED CTR SAN ANTONIO,EMERGENCY MED RESIDENCY,FT SAM HOUSTON,TX 78234, USA. NR 8 TC 1 Z9 1 U1 0 U2 2 PU HANLEY & BELFUS INC PI PHILADELPHIA PA 210 S 13TH ST, PHILADELPHIA, PA 19107 SN 1069-6563 J9 ACAD EMERG MED JI Acad. Emerg. Med. PD APR PY 1995 VL 2 IS 4 BP 320 EP & PG 0 WC Emergency Medicine SC Emergency Medicine GA RA302 UT WOS:A1995RA30200016 PM 11727692 ER PT J AU BROWN, AE LANE, JR WAGNER, KF ZHOU, S CHUNG, R RAY, KL BLATT, SP AF BROWN, AE LANE, JR WAGNER, KF ZHOU, S CHUNG, R RAY, KL BLATT, SP TI RATES OF P24 ANTIGENEMIA AND VIRAL ISOLATION IN COMPARABLE WHITE AND BLACK HIV-INFECTED SUBJECTS SO AIDS LA English DT Article DE HIV; AIDS; P24 ANTIGEN; RACE; MILITARY MEDICINE ID IMMUNODEFICIENCY-VIRUS TYPE-1; CAPTURE ASSAY AB Objective: To determine the relative frequencies of HIV-1 p24 antigen and culture positivity in white and black patients. Design: Volunteers in the US military's HIV natural history study were 46% white, 44% black, 7% Hispanic and 3% other. Focusing on the comparable groups of whites and blacks, a retrospective analysis was performed of the results of virologic assays collected over a 2-year period. Methods: p24 antigen was quantitated in sera with and without immune complex dissociation (ICD); viral isolation was performed by coculture of peripheral blood mononuclear cells. Results: Results of the two virologic assays were very similar in the two racial groups, both overall and after stratification by CD4 cell count. As reported previously, the concentration of serum immunoglobulin G was found to be greater in black than white subjects. In contrast to results with ICD, sera tested without ICD resulted in differing (higher) rates of antigenemia in whites than blacks (P=0.002). Conclusions: The frequencies of p24 antigen and culture positivity were found to be independent of race. Previously observed racial differences in antigen positivity were likely to be due to more extensive antibody binding in blacks than in whites. C1 WALTER REED ARMY INST RES,DIV PREVENT MED,ROCKVILLE,MD 20850. SRA TECHNOL,ROCKVILLE,MD. HENRY M JACKSON FDN,ROCKVILLE,MD. USN,MED CTR,BETHESDA,MD 20889. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. WILFORD HALL USAF MED CTR,SAN ANTONIO,TX 78236. RP BROWN, AE (reprint author), WALTER REED ARMY INST RES,DEPT RETROVIRAL RES,SUITE 201,13 TAFT COURT,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 NR 17 TC 6 Z9 6 U1 0 U2 0 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0269-9370 J9 AIDS JI Aids PD APR PY 1995 VL 9 IS 4 BP 325 EP 328 PG 4 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA QP022 UT WOS:A1995QP02200002 PM 7794537 ER PT J AU SMITH, KJ SKELTON, HG ANGRITT, P AF SMITH, KJ SKELTON, HG ANGRITT, P TI CHANGES OF VERRUCIFORM XANTHOMA IN AN HIV-1+ PATIENT WITH DIFFUSE PSORIASIFORM SKIN-DISEASE SO AMERICAN JOURNAL OF DERMATOPATHOLOGY LA English DT Note DE VERRUCIFORM XANTHOMA; PSORIASIS; HIV ID INFECTION; CHILD; LIGHT AB Verruciform xanthoma occurs most commonly in the oral mucosa; however, rare cutaneous lesions have been described. Although the pathogenesis of this entity is not known, dysregulation of epithelial proliferation and degenerative changes in the epithelium may explain the occurrence of this lesion in association with inflammatory dermatoses, epithelial hamartomas, and epithelial dysplasia. We report an HIV-1+ patient with diffuse psoriasiform skin lesions that showed histologic changes of verruciform xanthoma. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. AIDS REGISTRY,WASHINGTON,DC. RP SMITH, KJ (reprint author), ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306, USA. NR 26 TC 13 Z9 13 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0193-1091 J9 AM J DERMATOPATH JI Am. J. Dermatopathol. PD APR PY 1995 VL 17 IS 2 BP 185 EP 188 DI 10.1097/00000372-199504000-00012 PG 4 WC Dermatology SC Dermatology GA QP639 UT WOS:A1995QP63900013 PM 8600786 ER PT J AU YAVORSKI, RT WONG, RKH MAYDONOVITCH, C BATTIN, LS FURNIA, A AMUNDSON, DE AF YAVORSKI, RT WONG, RKH MAYDONOVITCH, C BATTIN, LS FURNIA, A AMUNDSON, DE TI ANALYSIS OF 3,294 CASES OF UPPER GASTROINTESTINAL-BLEEDING IN MILITARY MEDICAL FACILITIES SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article ID NATIONAL ASGE SURVEY; PROGNOSTIC FACTORS; SEX-DIFFERENCES; ULCER DISEASE; PEPTIC-ULCER; HEMORRHAGE; RECURRENCE; MANAGEMENT; ENDOSCOPY; MORTALITY AB Objectives: Upper gastrointestinal bleeding (UGIB) remains a commonly encountered medical emergency with significant morbidity and mortality. Most large studies detailing the specific incidence, demographic, and mortality data were performed more than a decade ago. This study analyzes 3,294 cases of UGIB from 139 military medical treatment facilities over a 12-month period. Methods: A retrospective chart review of Department of Defense military medical treatment facilities for UGIB was performed from October 1990 through September 1991. Core data such as demographic information were analyzed, as well as specific data relating to UGIB. Results: The incidence of UGIB was 36 per 100,000 population with a male-to-female ratio of 2.18 and a mean age of 52 +/- 19.65 yr. The number of cases increased with age; 44.5% of all patients were greater than or equal to 60 yr old. The overall mortality was 7.0% (231 of 3294), and death rates were similar among males and females (7.1% vs. 6.8%) with an odds ratio of 1.03 (CI: 0.77-1.402). Mortality increased with age in both genders; 73.2% of deaths occurred in patients more than 60 yr old. Comorbid illness was noted in 50.9% (1675 of 3294) of patients, with similar occurrence in males (48.7%) and females (55.4%). One or more comorbid illnesses were noted in 98.3% of the patients who died, and in 72.3% of cases, they were the primary cause of death. Bleeding was the primary cause of death in 18.6% of patients. Upper endoscopy was performed in 68.8% of cases, therapeutic endoscopy in 12.6%, repeat endoscopy in 10.7%, and surgery in 4.4%. Blood transfusions were administered in 47.3% of cases, with most patients receiving < 5 units of blood. Rebleeding after initial hemostasis was noted in 7.1% of cases. Factors related to increased mortality include age > 60 (p < 0.001), transfusion requirement > 5 U (p < 0.001), presence of comorbid illness (p < 0.001), rebleeding after initial hemostasis (p < 0.005), surgery (p < 0.001), and UGIB occurring during hospitalization (p = 0.027). Conclusions: We conclude: 1) The incidence of UGIB is 2-fold greater in males than in females, in all age groups; however, the death rate is similar in both sexes. 2) The mortality rate in this study is slightly lower than in most previous studies and may be more reflective of the average mortality in the community at large. 3) In UGIB patients, comorbid illness and not actual bleeding is the major cause of death. 4) Upper endoscopy was performed less often in this study than in other studies, and there were fewer blood transfusions; however, rebleeding and mortality rates remained similar. C1 WALTER REED ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,WASHINGTON,DC 20307. FORENS MED ADVISORY SERV INC,ROCKVILLE,MD. USN,MED CTR,DEPT CRIT CARE,SAN DIEGO,CA 92152. NR 32 TC 114 Z9 120 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD APR PY 1995 VL 90 IS 4 BP 568 EP 573 PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA QR280 UT WOS:A1995QR28000008 PM 7717312 ER PT J AU SPIRNAK, JP NIEVES, N HOLLSTEN, DA WHITE, WC BETZ, TA AF SPIRNAK, JP NIEVES, N HOLLSTEN, DA WHITE, WC BETZ, TA TI GADOLINIUM-ENHANCED MAGNETIC-RESONANCE-IMAGING ASSESSMENT OF HYDROXYAPATITE ORBITAL IMPLANTS SO AMERICAN JOURNAL OF OPHTHALMOLOGY LA English DT Article ID CORALLINE HYDROXYAPATITE; HYDROXYLAPATITE AB PURPOSE: Successful prosthesis attachment depends on complete vascularization of porous coral-line hydroxyapatite when it is used as an orbital implant. We retrospectively assessed the utility of gadolinium-enhanced magnetic resonance imaging to evaluate and characterize the temporal progression of this fibrovascular process, which has been histologically documented elsewhere. METHODS: Serial T-1-weighted gadolinium enhanced orbital magnetic resonance examinations were performed in five patients receiving hydroxyapatite orbital implants. Retrospective evaluation of the enhancement patterns was per formed. Magnetic resonance imaging enhance ment patterns guided timing of final drilling for prosthesis fixation. RESULTS: Serial gadolinium enhanced T-1-weighted sequences consistently demonstrated centrally advancing, peripheral enhancement cen tered on the drilled access channels. Progression over time varied, with the following two patterns demonstrated: (1) rapid peripheral enhancement, which led to diffuse enhancement (three patients); and (2) enhancement limited to the periphery, which failed to advance centrally. CONCLUSIONS: The temporal enhancement seen on magnetic resonance imaging is identical to the histologically proven fibrovascular ingrowth pattern and most likely reflects this process. Magnetic resonance imaging can identify progression of fibrovascular ingrowth into the hydroxyapatite orbital implants and guide surgical planning. It may also identify implants that fail to vascularize, thereby preventing the morbidity encountered by drilling into an avascular hydroxyapatite implant. C1 BROOKE ARMY MED CTR,DEPT RADIOL,FT SAM HOUSTON,TX. RP SPIRNAK, JP (reprint author), DWIGHT D EISENHOWER ARMY MED CTR,DEPT RADIOL,HSHR-R,FT GORDON,GA 30905, USA. NR 18 TC 23 Z9 27 U1 1 U2 3 PU OPHTHALMIC PUBL CO PI CHICAGO PA 77 WEST WACKER DR, STE 660, CHICAGO, IL 60601 SN 0002-9394 J9 AM J OPHTHALMOL JI Am. J. Ophthalmol. PD APR PY 1995 VL 119 IS 4 BP 431 EP 440 PG 10 WC Ophthalmology SC Ophthalmology GA QR237 UT WOS:A1995QR23700005 PM 7535979 ER PT J AU KILKENNY, TE SWENSON, GW AF KILKENNY, TE SWENSON, GW TI KELOIDS OF THE BREAST - MAMMOGRAPHIC FINDINGS SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Letter RP KILKENNY, TE (reprint author), TRIPLER ARMY MED CTR,HONOLULU,HI 96859, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD APR PY 1995 VL 164 IS 4 BP 1022 EP 1022 PG 1 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA QN207 UT WOS:A1995QN20700055 PM 7726020 ER PT J AU LONG, GW FRIES, L WATT, GH HOFFMAN, SL AF LONG, GW FRIES, L WATT, GH HOFFMAN, SL TI POLYMERASE CHAIN-REACTION AMPLIFICATION FROM PLASMODIUM-FALCIPARUM ON DRIED BLOOD SPOTS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; FILTER-PAPER; WHOLE-BLOOD; PCR; DNA; MALARIA; SAMPLES AB We report a simple method for the polymerase chain reaction (PCR) amplification of whole blood samples collected on filter paper. The blood spot was used directly in the PCR after treatment with methanol. We evaluated this assay using clinical samples collected from subjects in a Plasmodium falciparum vaccine trial and from samples collected during a hospital-based study in Thailand. Specimens prepared from heparinized blood samples were successfully amplified following pretreatment with heparinase. Sensitivity was 100% when compared with thick blood film results in the vaccine trial (range = 4-60 parasites/mu l, median = 8/mu l) and 94.6% (range = 3-133,988 parasites/mu l, median = 616/mu l) in the hospital study. C1 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,CTR VACCINE RES,BALTIMORE,MD 21205. ARMED FORCES RES INST MED SCI,DEPT MED,BANGKOK 10400,THAILAND. RP LONG, GW (reprint author), USN,MED RES INST,MALARIA PROGRAM,12300 WASHINGTON AVE,ROCKVILLE,MD 20852, USA. NR 18 TC 23 Z9 23 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 1995 VL 52 IS 4 BP 344 EP 346 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA QX896 UT WOS:A1995QX89600013 PM 7741174 ER PT J AU PANG, L ALENCAR, FEC CERUTTI, C MILHOUS, WK ANDRADE, AL OLIVEIRA, R KANESATHASAN, N MACARTHY, PO HOKE, CH AF PANG, L ALENCAR, FEC CERUTTI, C MILHOUS, WK ANDRADE, AL OLIVEIRA, R KANESATHASAN, N MACARTHY, PO HOKE, CH TI SHORT REPORT - HEPATITIS-E INFECTION IN THE BRAZILIAN AMAZON SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Note ID LINKED-IMMUNOSORBENT-ASSAY; E VIRUS; CHILDREN; ANTIBODY AB This is the first report of serlogic evidence of hepatitis E infection in Brazil. During a community-based survey of healthy individuals, six of 97 gold miners in the Amazon region of Mato Grosso had antibody to the virus. The mining camps have poor sanitation with a great potential for fecal-oral transmission of disease. Since levels of hepatitis E antibodies may quickly wane, studies to directly measure the incidence of seroconversion are planned to determine the intensity of transmission in this area. C1 FED UNIV GOIAS,INST TROP PATHOL & PUBL HLTH,GOIANIA,GO,BRAZIL. WALTER REED ARMY INST RES,WASHINGTON,DC. RP PANG, L (reprint author), USA,MED RES UNIT BRAZIL,RIO JANEIRO,BRAZIL. RI Andrade, Ana Lucia/L-5751-2013; Cerutti Junior, Crispim/C-4529-2011 NR 11 TC 21 Z9 23 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 1995 VL 52 IS 4 BP 347 EP 348 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA QX896 UT WOS:A1995QX89600014 PM 7741175 ER PT J AU POTEGAL, M COOMBES, K AF POTEGAL, M COOMBES, K TI ATTACK PRIMING AND AGGRESSIVE AROUSAL IN FEMALE SYRIAN GOLDEN-HAMSTERS, MESOCRICETUS-AURATUS SO ANIMAL BEHAVIOUR LA English DT Article ID INTRASPECIFIC AGGRESSION; AGONISTIC BEHAVIOR; TIME COURSE; RATS AB Earlier studies have found that priming a resident female hamster by allowing it to attack a conspecific intruder transiently reduced the latency of its attack on a second (probe) intruder. The present series of experiments showed that the time the subject spent in contact with each intruder prior to attack revealed this priming effect more clearly than did the conventional total elapsed time measure. The inference that stimuli encountered during the first few minutes of intruder exploration would heighten the subject's aggressive arousal was confirmed in experiments showing that increasing exposure to an anaesthetized intruder from 0 to 90 s systematically reduced subsequent attack latency. Ninety seconds of contact with an anaesthetized intruder just prior to testing on a pair of priming and probe trials significantly reduced the priming effect. However, such exposure may not reproduce the full reduction in latency that follows an overt attack. Consecutive priming and probe attack latencies were uncorrelated even though the latter is routinely shorter than the former. Attacks were therefore modelled as stochastic events. Standard log survivor analysis suggested that attack probabilities increase to an asymptote during both priming and probe trials. A novel theta(t) transformation of the data showed more clearly that the priming effect results from a probability of attack which starts at a higher level on probe trials and rises to asymptote faster. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307. UNIV MARYLAND,DEPT MATH,COLLEGE PK,MD 20742. NR 38 TC 13 Z9 13 U1 0 U2 1 PU ACADEMIC PRESS (LONDON) LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0003-3472 J9 ANIM BEHAV JI Anim. Behav. PD APR PY 1995 VL 49 IS 4 BP 931 EP 947 DI 10.1006/anbe.1995.0124 PG 17 WC Behavioral Sciences; Zoology SC Behavioral Sciences; Zoology GA QT441 UT WOS:A1995QT44100007 ER PT J AU BURCH, HB WARTOFSKY, L BURMAN, KD AF BURCH, HB WARTOFSKY, L BURMAN, KD TI ANTITHYROID DRUGS AND RADIOIODINE THERAPY SO ANNALS OF INTERNAL MEDICINE LA English DT Letter C1 WASHINGTON HOSP CTR,WASHINGTON,DC 20010. RP BURCH, HB (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD APR 1 PY 1995 VL 122 IS 7 BP 554 EP 554 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA QP008 UT WOS:A1995QP00800016 PM 7532924 ER PT J AU BURCH, HB BURMAN, KD WARTOFSKY, L AF BURCH, HB BURMAN, KD WARTOFSKY, L TI RADIOIODINE THERAPY IN GRAVES-DISEASE - RESPONSE SO ANNALS OF INTERNAL MEDICINE LA English DT Letter C1 WASHINGTON HOSP CTR,WASHINGTON,DC 20010. RP BURCH, HB (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD APR 1 PY 1995 VL 122 IS 7 BP 555 EP 555 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA QP008 UT WOS:A1995QP00800019 ER PT J AU BROWN, TD FLEMING, TR GOODMAN, PJ MACDONALD, JS PUGH, RP OROURKE, T AF BROWN, TD FLEMING, TR GOODMAN, PJ MACDONALD, JS PUGH, RP OROURKE, T TI A RANDOMIZED TRIAL OF 2 SCHEDULES OF TRIMETREXATE VERSUS 5-FLUOROURACIL IN ADVANCED COLORECTAL-CANCER - A SOUTHWEST-ONCOLOGY-GROUP STUDY SO ANTI-CANCER DRUGS LA English DT Article DE ADVANCED COLORECTAL CANCER; 5-FLUOROURACIL; PHASE II-III TRIAL; TRIMETREXATE ID CLINICAL-PHARMACOLOGY; PHASE-I AB Trimetrexate (TMQ), a non-classical folate antagonist, was studied in a randomized controlled trial in patients with advanced colorectal cancer and without prior chemotherapy. Patients were randomly assigned to one of three treatments: TMQ at 200 mg/m(2) i.v.q 2 weeks, TMQ at 12mg/m(2) i.v. weekly. Overall response rates were: 6% (four partial responses in 71 patients, 95% Cl of 2-14% for q 2 week TMQ, O% (zero of 29, 95% Cl of 0-29% for daily x 5 TMQ and 18% (two complete and nine partial responses in 62 patients, 95% Cl or 9-30%) for 5-FU. Median survival estimates were 10.3 months for the q 2 week TMQ schedule, 8.7 months for the daily x 5 TMQ schedule and 13.6 months for the 5-FU schedule. Grade less than or equal to 3 toxicities were significantly more common with TMQ. TMQ does not appear to have significant anti-tumor activity against colorectal cancer. C1 NORFOLK DIAGNOST CLIN,NORFOLK,VA 23502. SW ONCOL GRP,CTR STAT,SEATTLE,WA. TEMPLE UNIV,PHILADELPHIA,PA. ALLEGHENY HLTH EDUC & RES,PITTSBURGH,PA. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX. FU NCI NIH HHS [CA22433, CA35112, CA37429] NR 14 TC 7 Z9 7 U1 1 U2 1 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0959-4973 J9 ANTI-CANCER DRUG JI Anti-Cancer Drugs PD APR PY 1995 VL 6 IS 2 BP 219 EP 223 DI 10.1097/00001813-199504000-00004 PG 5 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA QU087 UT WOS:A1995QU08700004 PM 7795270 ER PT J AU KIMBERLIN, DW SPECTOR, SA HILL, EL BIRON, KK HAY, AJ MAYERS, DL WHITLEY, RJ AF KIMBERLIN, DW SPECTOR, SA HILL, EL BIRON, KK HAY, AJ MAYERS, DL WHITLEY, RJ TI ASSAYS FOR ANTIVIRAL DRUG-RESISTANCE SO ANTIVIRAL RESEARCH LA English DT Article; Proceedings Paper CT State-of-the-Art Symposium on Antiviral Resistance CY DEC 08-10, 1994 CL NEW YORK, NY SP MACRE GRP, INT SOC ANTIVIRAL RES, NIAID ID HUMAN-IMMUNODEFICIENCY-VIRUS; HERPES-SIMPLEX VIRUS; ZIDOVUDINE RESISTANCE; INFLUENZA; MUTATIONS; CYTOMEGALOVIRUS; INFECTION; MUTANTS; TYPE-1; DNA C1 UNIV CALIF SAN DIEGO,LA JOLLA,CA. BURROUGHS WELLCOME CO,RES TRIANGLE PK,NC. NATL INST MED RES,LONDON,ENGLAND. WALTER REED ARMY INST RES,ROCKVILLE,MD. RP KIMBERLIN, DW (reprint author), UNIV ALABAMA,DEPT PEDIAT,1600 7TH AVE S,SUITE 616,BIRMINGHAM,AL 35233, USA. NR 22 TC 6 Z9 6 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD APR PY 1995 VL 26 IS 4 BP 403 EP 413 DI 10.1016/0166-3542(95)00028-K PG 11 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA QZ059 UT WOS:A1995QZ05900003 PM 7574542 ER PT J AU ENGELL, D TOURILA, H RADOVSKY, E MEISELMAN, A AF ENGELL, D TOURILA, H RADOVSKY, E MEISELMAN, A TI SENSORY INFLUENCES ON PREDICTED AND ACTUAL BEVERAGE INTAKE FOLLOWING EXERCISE SO APPETITE LA English DT Meeting Abstract C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. HELSINKI UNIV,HELSINKI,FINLAND. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS (LONDON) LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0195-6663 J9 APPETITE JI Appetite PD APR PY 1995 VL 24 IS 2 BP 186 EP 186 PG 1 WC Behavioral Sciences; Nutrition & Dietetics SC Behavioral Sciences; Nutrition & Dietetics GA QQ655 UT WOS:A1995QQ65500025 ER PT J AU MEISELMAN, HL MASTROIANNI, GR EDWARDS, J AF MEISELMAN, HL MASTROIANNI, GR EDWARDS, J TI A LONGITUDINAL-STUDY OF FOOD-HABITS, ATTITUDES AND HUMAN-PERFORMANCE SO APPETITE LA English DT Meeting Abstract C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. GEOCENTERS INC,NEWTON,MA 02159. BOURNEMOUTH UNIV,BOURNEMOUTH,DORSET,ENGLAND. NR 0 TC 1 Z9 1 U1 1 U2 2 PU ACADEMIC PRESS (LONDON) LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0195-6663 J9 APPETITE JI Appetite PD APR PY 1995 VL 24 IS 2 BP 193 EP 193 PG 1 WC Behavioral Sciences; Nutrition & Dietetics SC Behavioral Sciences; Nutrition & Dietetics GA QQ655 UT WOS:A1995QQ65500043 ER PT J AU STANLEY, AE AF STANLEY, AE TI FT-IR ANALYSIS OF THE LASER-INDUCED DISSOCIATION OF METHYLPHOSPHONIC DIFLUORIDE SO APPLIED SPECTROSCOPY LA English DT Article DE LASER; INFRARED; METHYLPHOSPHONIC DIFLUORIDE ID KINETICS AB The output of a continuous-wave carbon dioxide laser was used successfully for the dissociation of methylphosphonic difluoride. End product analysis using Fourier transform infrared spectroscopy revealed that the phosphorus-to-carbon bond was cleaved, yielding the products methane, ethene, ethyne, hydrophosphoryl difluoride, and a mixture of phosphorus compounds. These results are presented and discussed. The dissociation was optimized. A reaction mechanism of the dissociation is suggested. RP STANLEY, AE (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,AMSMI RD WS CM,WEAPONS SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. NR 20 TC 0 Z9 0 U1 0 U2 0 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA PO BOX 1438, FREDERICK, MD 21701 SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD APR PY 1995 VL 49 IS 4 BP 478 EP 481 DI 10.1366/0003702953964219 PG 4 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA QV637 UT WOS:A1995QV63700013 ER PT J AU GOLDBERG, MK RUSSELL, HC AF GOLDBERG, MK RUSSELL, HC TI TOWARD COMPUTING M(4) SO ARS COMBINATORIA LA English DT Article ID HYPERGRAPHS C1 RENSSELAER POLYTECH INST,DEPT COMP SCI,TROY,NY 12181. US MIL ACAD,DEPT MATH,W POINT,NY 10996. LOS ALAMOS NATL LAB,LOS ALAMOS,NM. NR 15 TC 4 Z9 6 U1 0 U2 0 PU CHARLES BABBAGE RES CTR PI WINNIPEG PA PO BOX 272 ST NORBERT POSTAL STATION, WINNIPEG MB R3T 2N2, CANADA SN 0381-7032 J9 ARS COMBINATORIA JI ARS Comb. PD APR PY 1995 VL 39 BP 139 EP 148 PG 10 WC Mathematics SC Mathematics GA QY408 UT WOS:A1995QY40800014 ER PT J AU MUTALIB, A KEIRS, R MASLIN, W TOPPER, M DUBEY, JP AF MUTALIB, A KEIRS, R MASLIN, W TOPPER, M DUBEY, JP TI SARCOCYSTIS-ASSOCIATED ENCEPHALITIS IN CHICKENS SO AVIAN DISEASES LA English DT Note ID FALCATULA AB Sarcocystis-associated encephalitis was diagnosed in a backyard chicken nock that had nervous manifestations. The main histopathologic lesion was necrotizing encephalitis characterized by a large focal area of necrosis infiltrated and surrounded by mononuclear cells, heterophils, and multinucleated giant cells. Schizonts and merozoites were observed in the lesion. Immunohistochemical staining of the brain lesion revealed positive reaction to Sarcocystis antiserum. The ultrastructural characteristics of the parasite were typical of Sarcocystis, including the presence of a nucleus, a conoid, numerous micronemes, and lack of rhoptries. Medication with amprolium and sulfamethazine or with chlortetracycline was not effective in controlling the mortality. Trapping of opossums on the farm and relocating the chickens to clean, new premises seemed to reduce mortality from this infection. C1 WALTER REED ARMY INST RES,DIV PATHOL,WASHINGTON,DC 20307. USDA ARS,BELTSVILLE AGR RES CTR,LPSI,PARASITE BIOL & EPIDEMIOL LAB,BELTSVILLE,MD 20705. RP MUTALIB, A (reprint author), MISSISSIPPI STATE UNIV,COLL VET MED,MISSISSIPPI STATE,MS 39762, USA. NR 12 TC 14 Z9 14 U1 0 U2 1 PU AMER ASSOC AVIAN PATHOLOGISTS PI KENNETT SQ PA UNIV PENN, NEW BOLTON CENTER, KENNETT SQ, PA 19348-1692 SN 0005-2086 J9 AVIAN DIS JI Avian Dis. PD APR-JUN PY 1995 VL 39 IS 2 BP 436 EP 440 DI 10.2307/1591891 PG 5 WC Veterinary Sciences SC Veterinary Sciences GA RD512 UT WOS:A1995RD51200030 PM 7677669 ER PT J AU PANDOLF, KB STROSCHEIN, LA GONZALEZ, RR SAWKA, MN AF PANDOLF, KB STROSCHEIN, LA GONZALEZ, RR SAWKA, MN TI PREDICTING HUMAN HEAT STRAIN AND PERFORMANCE WITH APPLICATION TO SPACE OPERATIONS SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Note ID HYPOHYDRATION; TEMPERATURE; RESPONSES; EXERCISE; ENERGY; LOADS AB This Institute has developed a USARIEM Heat strain Prediction Model for predicting physiological responses and soldier performance in the heat, which has been programmed for use by handheld calculators and personal computers, and incorporated into the development of a hear strain decision aid. This model is demonstrated to predict accurately (generally within +/-1 SD/SEM) rectal temperature (Tie) responses for soldiers wearing various military clothing ensembles during U.S. or non-U.S. military sce narios in the heat at home or abroad. The value of this model is shown presently for three NASA scenarios involving the Launch and Entry Suit (LES). The LES (ventilated or unventilated) is modeled during pre-launch/launch, re-entry/landing, and emergency egress after re entry/landing scenarios, predominately to evaluate heat acclimation and hydration state effects. During the pre-launch/launch scenario, predicted final Tie closely agrees with observed values suggesting minimal heat strain (Tie similar to 38.0 degrees C). In contrast, dehydrated (3%) unacclimated individuals show moderate levels of heat strain (Tre similar to 38.5 degrees C) for this same scenario. During the re-entry/landing and emergency egress scenarios, dehydrated unacclimated individuals are predicted to exhibit excessive heat strain (Tre > 39.0 degrees C). Thermal tolerance time is predicted to be only 6 min during emergency egress if individuals are: dehydrated and unacclimated to heat while wearing the LES, If heat transfer values for space operations clothing are known, NASA can use this prediction model to help avoid undue heat strain involving astronauts for most scenarios during spaceflight. RP PANDOLF, KB (reprint author), USA,ENVIRONM MED RES INST,ENVIRONM PHYSIOL & MED DIRECTORATE,NATICK,MA 01760, USA. NR 19 TC 5 Z9 6 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD APR PY 1995 VL 66 IS 4 BP 364 EP 368 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA QQ607 UT WOS:A1995QQ60700012 PM 7794230 ER PT J AU ALBON, R AF ALBON, R TI JAPAN AT WAR - AN ORAL-HISTORY - COOK,HT, COOK,TF SO BULLETIN OF CONCERNED ASIAN SCHOLARS LA English DT Book Review RP ALBON, R (reprint author), USA,WASHINGTON,DC 20310, USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU BULL CONCERNED ASIAN SCH PI BOULDER PA BILL DOUB, MANAGING EDITOR 3239 9TH ST PHONE #303-449-7439, BOULDER, CO 80304-2112 SN 0007-4810 J9 B CONCERN ASIA SCHOL JI Bull. Concerned Asian Sch. PD APR-JUN PY 1995 VL 27 IS 2 BP 79 EP 80 PG 2 WC Area Studies SC Area Studies GA RY458 UT WOS:A1995RY45800015 ER PT J AU WOLFE, D WEBER, B WUERTZ, D WELSH, D MERRITT, D KING, S FRITZ, R MORAN, K SIMON, M SIMON, A COGAN, J LITTELL, D MEASURE, E AF WOLFE, D WEBER, B WUERTZ, D WELSH, D MERRITT, D KING, S FRITZ, R MORAN, K SIMON, M SIMON, A COGAN, J LITTELL, D MEASURE, E TI AN OVERVIEW OF THE MOBILE PROFILER SYSTEM - PRELIMINARY-RESULTS FROM FIELD-TESTS DURING THE LOS-ANGELES FREE-RADICAL STUDY SO BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY LA English DT Article ID RADAR MEASUREMENTS; WIND PROFILER; TEMPERATURE AB The System Demonstration and Integration Division of the Environmental Technology Laboratory and the Battlefield Environment Directorate of the U.S. Army Research Laboratory have designed and built the Mobile Profiler System (MPS). The MPS is an integrated system of ground-based and satellite-borne remote sensors that measure nearly continuous wind and temperature profiles from the surface up through the troposphere. Ground-based sensors include a 924-MHz phased-array wind and temperature profiler, a four-channel microwave radiometer, a surf ace meteorological tower, and a balloon sounding system. Although MPS was initially developed for military applications, the nonmilitary environmental applications are numerous and significant. This paper provides an overview of the instrumentation, software networking, data processing, data integration, and near real-time data display capabilities currently incorporated into the MPS. initial results from the first field tests (Los Angeles Free-Radical Study, 3-24 September 1993) demonstrate the ability of MPS to observe the complex meteorological structures associated with high-pollution events within the Los Angeles Basin. C1 UNIV COLORADO,COOPERAT INST RES ENVIRONM SCI,BOULDER,CO. USA,RES LAB,WHITE SANDS MISSILE RANGE,NM. RP WOLFE, D (reprint author), US DEPT COMMERCE,NOAA,ENVIRONM RES LABS,ENVIRONM TECHNOL LAB,DIV SYST DEMONSTRAT & INTEGRAT,BOULDER,CO 80303, USA. NR 30 TC 13 Z9 13 U1 0 U2 0 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 SN 0003-0007 J9 B AM METEOROL SOC JI Bull. Amer. Meteorol. Soc. PD APR PY 1995 VL 76 IS 4 BP 523 EP 534 DI 10.1175/1520-0477(1995)076<0523:AOOTMP>2.0.CO;2 PG 12 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA QV757 UT WOS:A1995QV75700004 ER PT J AU CIVANTOS, F MARCIAL, MA BANKS, ER HO, CK SPEIGHTS, VO DREW, PA MURPHY, WM SOLOWAY, MS AF CIVANTOS, F MARCIAL, MA BANKS, ER HO, CK SPEIGHTS, VO DREW, PA MURPHY, WM SOLOWAY, MS TI PATHOLOGY OF ANDROGEN DEPRIVATION THERAPY IN PROSTATE CARCINOMA - A COMPARATIVE-STUDY OF 173 PATIENTS SO CANCER LA English DT Article DE ANDROGEN DEPRIVATION; LEUPROLIDE; LUTEINIZING HORMONE-RELEASING HORMONE EFFECT; PROSTATE CANCER ID PROGRAMMED CELL-DEATH; ADENOCARCINOMA; CANCER; DIETHYLSTILBESTROL; LEUPROLIDE; CASTRATION; FLUTAMIDE; ANTIBODY AB Background. Leuprolide, an agonist of luteinizing hormone-releasing hormone (LH-RH), and flutamide, an antiandrogen, increasingly are being used in the treatment of clinically localized prostate cancer. Only two small series (of 23 and 12 patients) have been published on the distinctive pathologic changes induced in the prostate by androgen deprivation therapy with discrepancies on the presence of squamous metaplasia, necrosis, and possible tumor destruction by combined androgen deprivation-therapy. Methods. One hundred and thirteen radical prostatectomy specimens obtained after at least 3 months of leuprolide-flutamide androgen inhibition therapy and 60 nonhormonally treated prostates in randomly selected clinical Stage T2 prostate adenocarcinoma patients were entirely sectioned. Distinctive histologic findings were tabulated and their statistical value determined. Results. Resection margins of excision were involved by tumor in 43% of untreated and in 19% of androgen-deprived patients. Characteristic changes in androgen-inhibited nontumor glands included atrophy, basal cell prominence, vacuolated luminal cell layer, and squamous and transitional cell metaplasia. Prostatic intraepithelial neoplasia (PIN) was observed in 35% of treated patients. The presence of small tumor glands separated by stroma was the most frequently noted effect of androgen deprivation on prostate adenocarcinoma; pyknosis and branching empty spaces were less frequent. Large clear tumor cells within an inflammatory response was a third histologic pattern. Apparently unaltered tumor areas were observed in 43% of prostates exposed to androgen deprivation therapy. Conclusions. Androgen deprivation therapy results in histologically distinctive changes that can be recognized in both nonneoplastic and neoplastic prostate tissue. Residual tumor was present in all 113 treated radical prostatectomy specimens. In addition to glandular shrinkage, therapy was associated with statistically significant reductions in the frequency of high grade PIN and extension of cancer to prostate specimen margins of excisions. C1 UNIV CENT CARIBE,SCH MED,DEPT PATHOL,BAYAMON,PR. DEPT VET AFFAIRS MED CTR,DEPT PATHOL,LEXINGTON,KY. WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. TEXAS A&M UNIV,COLL MED,DEPT PATHOL,TEMPLE,TX 76508. SCOTT & WHITE MEM HOSP & CLIN,DEPT PATHOL,TEMPLE,TX 76508. UNIV FLORIDA,COLL MED,DEPT PATHOL,GAINESVILLE,FL. UNIV MIAMI,SCH MED,DEPT UROL,MIAMI,FL. RP CIVANTOS, F (reprint author), UNIV MIAMI,SCH MED,DEPT PATHOL,D-33,POB 016960,MIAMI,FL 33101, USA. NR 33 TC 83 Z9 87 U1 2 U2 2 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD APR 1 PY 1995 VL 75 IS 7 BP 1634 EP 1641 DI 10.1002/1097-0142(19950401)75:7<1634::AID-CNCR2820750713>3.0.CO;2-# PG 8 WC Oncology SC Oncology GA QN813 UT WOS:A1995QN81300012 PM 8826921 ER PT J AU MCLEOD, DG AF MCLEOD, DG TI HORMONAL-THERAPY IN THE TREATMENT OF CARCINOMA OF THE PROSTATE SO CANCER LA English DT Article; Proceedings Paper CT National Conference on Prostate Cancer CY SEP 29-OCT 01, 1994 CL PHILADELPHIA, PA DE PROSTATE CANCER; HORMONAL THERAPY; CLINICAL TRIALS; METASTATIC DISEASE ID CANCER; TRIAL; ORCHIECTOMY; FLUTAMIDE; ANTIGEN; SURAMIN AB Although chronic hormonal treatment is the cornerstone of therapy in metastatic disease, questions are being raised regarding the need for continual ablation. With increasing cognizance on quality-of-life issues and cost of therapy, an intergroup trial is being planned to compare intermittent combined hormonal therapy versus continual therapy in patients with minimal metastatic disease and good performance status. Newly diagnosed patients with severe metastatic disease should soon be eligible for a trial to evaluate the addition of the chemotherapeutic agent suramin to standard combined therapy. During the past several years there has been a trend toward the use of hormonal ablation in earlier stages of prostate cancer. Hormonal therapy is being used with increasing frequency in both neoadjuvant and adjuvant settings, and the use of prostate specific antigen is one prognostic factor that has shifted the focus in follow-up and treatment of all stages of the disease. To answer the challenges in the treatment of prostatic cancer, clinical trials are playing an increasingly important role in the diagnosis and treatment of this disease. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP MCLEOD, DG (reprint author), WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307, USA. NR 28 TC 12 Z9 12 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD APR 1 PY 1995 VL 75 IS 7 SU S BP 1914 EP 1919 DI 10.1002/1097-0142(19950401)75:7+<1914::AID-CNCR2820751626>3.0.CO;2-Q PG 6 WC Oncology SC Oncology GA QP393 UT WOS:A1995QP39300024 ER PT J AU TORRINGTON, KG FINELLI, MR AF TORRINGTON, KG FINELLI, MR TI SMALL-VOLUME BRONCHOALVEOLAR LAVAGE USED IN DIAGNOSING PNEUMOCYSTIS-CARINII PNEUMONIA IN HIV-INFECTED PATIENTS SO CHEST LA English DT Article ID ACQUIRED IMMUNODEFICIENCY SYNDROME; SPECIMENS AB To determine the volume of bronchoalveolar lavage (BAL) fluid necessary to diagnose Pneumocystis carinii pneumonia (PCP) in immunocompromised patients, specimens from 25 patients were evaluated. Twenty-one patients were HIV infected. BAL was performed using three to four 60-mL aliquots of room temperature, sterile, saline solution. Each syringe of BAL effluent was numbered and its volume was measured. Immunofluorescent stains were performed on about 8-mL aliquots of the initial, final, and aggregate BAL specimens, and a modified Giemsa stain was also performed on a 0.4-mL aliquot of the aggregate specimen. Of 25 patients, Pneumocystis carinii organisms were identified in 9 with HIV infection, in whom all BAL specimens were positive with both immunofluorescence and Giemsa stains. In 16 patients, BAL specimens were negative for P carinii on both immunofluorescent and modified Giemsa testing. Both staining methods were 100% specific (95% confidence interval [CI], 83 to 100%) and 100% sensitive (95% CI, 72 to 100%). The volume of BAL effluent in the initial specimens positive for P carinii ranged from 15 to 25 mL. We conclude that in this small group of patients, PCP was accurately diagnosed from a single 60-mL BAL specimen stained with immunofluorescence methods. C1 WALTER REED ARMY MED CTR,DEPT PATHOL,SPECIAL DIAGNOST SECT,WASHINGTON,DC 20307. RP TORRINGTON, KG (reprint author), WALTER REED ARMY MED CTR,DEPT ARMY,PULM & CRIT CARE MED SERV,WASHINGTON,DC 20307, USA. NR 14 TC 7 Z9 7 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD APR PY 1995 VL 107 IS 4 BP 1013 EP 1017 DI 10.1378/chest.107.4.1013 PG 5 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA QR617 UT WOS:A1995QR61700027 PM 7705107 ER PT J AU STEINBAUM, SS URETZKY, ID MCADAMS, HP TORRINGTON, KG COHEN, AJ AF STEINBAUM, SS URETZKY, ID MCADAMS, HP TORRINGTON, KG COHEN, AJ TI EXPLORATORY THORACOTOMY FOR NONRESECTABLE LUNG-CANCER SO CHEST LA English DT Article DE LUNG NEOPLASM; THORACOSCOPY; THORACOTOMY ID BRONCHOGENIC-CARCINOMA; COMPUTED-TOMOGRAPHY; MEDIASTINUM; EFFICACY AB We sought to evaluate the effect of new diagnostic modalities on patients explored surgically for inoperable lung cancer, From July 1983 to February 1992, 335 patients underwent thoracotomy for lung cancer, Thirty-three of the 35 patients with nonresectable disease had sufficient data for analysis and underwent chest radiography (CXR), CT scan, and bronchoscopy. The study was terminated when video-assisted thoracoscopy (VAT) was introduced at the institution, Causes of nonresectability included significant Na disease not diagnosed preoperatively (n=11), tumor invasion of contiguous mediastinal structures (n=8), and insufficient pulmonary function (n=4). Four patients were left with unresected disease because of thoracic metastasis, Two patients had technically unresectable disease; three patients were explored surgically because diagnoses could be obtained by no other means. One patient was found to have small cell, cancer, Data analysis demonstrated that 19 of 33 thoracotomies could potentially have been avoided or resulted in resection with current techniques, Refinement of imaging criteria, a judicious surgical approach to N-2 disease, and VAT may significantly reduce thoracotomies for nonresectable lung cancer. C1 WALTER REED ARMY MED CTR,DEPT THORAC SURG,WASHINGTON,DC. RI McAdams, Holman/N-8218-2015 OI McAdams, Holman/0000-0002-7044-3320 NR 9 TC 12 Z9 12 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD APR PY 1995 VL 107 IS 4 BP 1058 EP 1061 DI 10.1378/chest.107.4.1058 PG 4 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA QR617 UT WOS:A1995QR61700037 PM 7705117 ER PT J AU HOLMES, DR TOPOL, EJ CALIFF, RM BERDAN, LG LEYA, F BERGER, PB WHITLOW, PL SAFIAN, RD ADELMAN, AG KELLETT, MA TALLEY, JD SHANI, J GOTTLIEB, RS PINKERTON, CA LEE, KL KEELER, GP ELLIS, SG FRANCO, I DEBOWEY, D LINCOFF, M KEREIAKES, D ABBOTTSMITH, C KENT, K LEON, M PICHARD, A SATLER, L POPMA, J HINOHARA, T KOSINSKI, E SIMONTON, C BERSIN, RM CEDARHOLM, J WILSON, B MCKEEVER, LS MARTIN, F CHAPEKIS, A GEORGE, BS COWLEY, M PINKERTON, C PETERS, T COHEN, M JACOBS, A FAXON, DP LEVINE, G KELLETT, M KING, S MASDEN, R MOONEY, M WHITE, CJ HOFLING, B WILLIAMS, D TALLEY, D WHITE, H BRINKER, J STEWART, DK CHAMBERS, J AU, P PALACIOS, I KUNTZ, R SAFIAN, R IVANHOE, R PUEL, J RAYBUCK, B BONAN, R PEARSON, C LAIRD, JR BURWELL, L CARNEY, RJ BELLINGER, R RICCI, D SPOKOJNY, A MARTYAK, TE COHEN, E ADELMAN, A LEWIS, S WEBB, J TRABOULSI, D REEN, B NIESS, G SLATER, J MARQUIS, JF BUSH, HS MOSES, JW HEUSER, R AYRES, M APFELBAUM, MA BLEICH, S ROUBIN, G STEIN, R HARTMAN, CW DENARDO, R LINDSEY, D CORIN, W UNTERECKER, B STILLABOWER, M MICK, M SHARMA, S COHEN, H BARBEAU, G GRIFFIN, J ARNOLD, A CALIFF, R AF HOLMES, DR TOPOL, EJ CALIFF, RM BERDAN, LG LEYA, F BERGER, PB WHITLOW, PL SAFIAN, RD ADELMAN, AG KELLETT, MA TALLEY, JD SHANI, J GOTTLIEB, RS PINKERTON, CA LEE, KL KEELER, GP ELLIS, SG FRANCO, I DEBOWEY, D LINCOFF, M KEREIAKES, D ABBOTTSMITH, C KENT, K LEON, M PICHARD, A SATLER, L POPMA, J HINOHARA, T KOSINSKI, E SIMONTON, C BERSIN, RM CEDARHOLM, J WILSON, B MCKEEVER, LS MARTIN, F CHAPEKIS, A GEORGE, BS COWLEY, M PINKERTON, C PETERS, T COHEN, M JACOBS, A FAXON, DP LEVINE, G KELLETT, M KING, S MASDEN, R MOONEY, M WHITE, CJ HOFLING, B WILLIAMS, D TALLEY, D WHITE, H BRINKER, J STEWART, DK CHAMBERS, J AU, P PALACIOS, I KUNTZ, R SAFIAN, R IVANHOE, R PUEL, J RAYBUCK, B BONAN, R PEARSON, C LAIRD, JR BURWELL, L CARNEY, RJ BELLINGER, R RICCI, D SPOKOJNY, A MARTYAK, TE COHEN, E ADELMAN, A LEWIS, S WEBB, J TRABOULSI, D REEN, B NIESS, G SLATER, J MARQUIS, JF BUSH, HS MOSES, JW HEUSER, R AYRES, M APFELBAUM, MA BLEICH, S ROUBIN, G STEIN, R HARTMAN, CW DENARDO, R LINDSEY, D CORIN, W UNTERECKER, B STILLABOWER, M MICK, M SHARMA, S COHEN, H BARBEAU, G GRIFFIN, J ARNOLD, A CALIFF, R TI A MULTICENTER, RANDOMIZED TRIAL OF CORONARY ANGIOPLASTY VERSUS DIRECTIONAL ATHERECTOMY FOR PATIENTS WITH SAPHENOUS-VEIN BYPASS GRAFT LESIONS SO CIRCULATION LA English DT Article DE ANGIOPLASTY; REVASCULARIZATION ID TRANS-LUMINAL ANGIOPLASTY; AORTOCORONARY BYPASS; BALLOON ANGIOPLASTY; FOLLOW-UP; RESTENOSIS; SURGERY; ATHEROSCLEROSIS; EXPERIENCE; STENOSIS; ARTERIES AB Background Directional coronary atherectomy and percutaneous transluminal coronary angioplasty have both been used in symptomatic patients with coronary saphenous vein bypass graft stenoses. The relative merits of plaque excision and removal versus balloon dilatation remain uncertain. We compared outcomes after directional coronary atherectomy or angioplasty in patients with de novo bypass graft stenoses. Methods and Results Fifty-four North American and European sites randomized 305 patients with de novo vein graft lesions to atherectomy (n=149) or angioplasty (n=156). Quantitative coronary angiography at a core laboratory assessed initial and 6-month results. Initial angiographic success was greater with atherectomy (89.2% versus 79.0%), as was initial luminal gain (1.45 versus 1.12 mm, P<.001). Distal embolization was increased with atherectomy (P=.012), and a trend was shown toward more non-Q-wave myocardial infarction (P=.09). Although the 6-month net minimum luminal diameter gain was 0.68 mm for atherectomy and 0.50 mm for angioplasty, the restenosis rates were similar, 45.6% for atherectomy and 50.5% for angioplasty (P=.491). At 6 months, there was a trend toward decreased repeated target-vessel interventions for atherectomy (P=.092); in addition, 13.2% of patients treated with atherectomy versus 22.4% of the angioplasty patients (P=.041) required repeated percutaneous intervention of the initial target lesion. Conclusions Atherectomy of de novo vein graft lesions was associated with improved initial angiographic success and luminal diameter but also with increased distal embolization. There was no difference in 6-month restenosis rates, although primary atherectomy patients tended to require fewer target-vessel revascularization procedures. C1 CLEVELAND CLIN FDN,CLEVELAND,OH 44195. DUKE UNIV,MED CTR,DURHAM,NC. LOYOLA MED CTR,CHICAGO,IL. WILLIAM BEAUMONT ROYAL OAK HOSP,ROYAL OAK,MI. UNIV LOUISVILLE,LOUISVILLE,KY 40292. MAINE MED CTR,PORTLAND,ME 04102. MAIMONIDES HOSP,BROOKLYN,NY. GRAD HOSP PHILADELPHIA,PHILADELPHIA,PA 19146. TORONTO GEN HOSP,TORONTO,ON,CANADA. ST VINCENTS HOSP,INDIANAPOLIS,IN. CHRIST HOSP,CINCINNATI,OH 45219. CARDIOL CTR,WASHINGTON,DC. SEQUOIA HOSP,REDWOOD CITY,CA. ST VINCENTS MED CTR,BRIDGEPORT,CT. CAROLINAS MED CTR,CHARLOTTE,NC 28203. CAROLINAS HEART INST,CHARLOTTE,NC 28232. MIDWEST HEART RES FDN,LOMBARD,IL. METHODIST HOSP,MEMPHIS,TN. RIVERSIDE METHODIST HOSP,COLUMBUS,OH 43214. VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,RICHMOND,VA 23298. ST FRANCIS HOSP,BEECH GROVE,IN. BOSTON UNIV,MED CTR,BOSTON,MA. EMORY HOSP,ATLANTA,GA. JEWISH HOSP,LOUISVILLE,KY. MINNEAPOLIS HEART INST,MINNEAPOLIS,MN. OCHSNER FDN HOSP,NEW ORLEANS,LA. UNIV MUNICH,KLINIKUM GROSSHADERN,W-8000 MUNICH,GERMANY. RHODE ISL HOSP,PROVIDENCE,RI 02902. SW CARDIOL ASSOCIATES,ALBUQUERQUE,NM. GRAD CARDIOL CONSULTANTS,PHILADELPHIA,PA. JOHNS HOPKINS UNIV HOSP,BALTIMORE,MD. LOYOLA MED CTR,MAYWOOD,IL. UNIV WASHINGTON,SEATTLE,WA 98195. MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. BETH ISRAEL HOSP,BOSTON,MA 02215. FLORIDA HOSP,ORLANDO,FL. CHU RANGUEIL,F-31054 TOULOUSE,FRANCE. FAIRFAX HOSP,ANNANDALE,VA. MONTREAL HEART INST,MONTREAL,PQ H1T 1C8,CANADA. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIV VIRGINIA,CHARLOTTESVILLE,VA. MOTHER FRANCES,TYLER,TX. SUTTER HOSP,SACRAMENTO,CA. HAHNEMANN UNIV,PHILADELPHIA,PA. VANCOUVER GEN HOSP,VANCOUVER,BC,CANADA. CORNELL UNIV,MED CTR,NEW YORK HOSP,NEW YORK,NY 10021. HENRICO HOSP,FREDERICKSBURG,VA. TORONTO GEN HOSP,N YORK,ON,CANADA. MT SINAI HOSP,TORONTO,ON M5G 1X5,CANADA. CARLESTON MED CTR,CHARLESTON,WV. ST PAULS HOSP,VANCOUVER,BC V6Z 1Y6,CANADA. FOOTHILLS PROV GEN HOSP,CALGARY,AB,CANADA. PRESBYTERIAN HOSP,CHARLOTTE,NC. ST LUKES ROOSEVELT HOSP,NEW YORK,NY 10025. OTTAWA HEART,OTTAWA,ON,CANADA. CLEVELAND CLIN FLORIDA,FT LAUDERDALE,FL. LENOX HILL HOSP,NEW YORK,NY 10021. HEALTHWEST REG MED CTR,PHOENIX,AZ. FT SANDERS REG MED CTR,KNOXVILLE,TN. COLUMBIA PRESBYTERIAN MED CTR,NEW YORK,NY 10032. E JEFFERSON HOSP,METAIRIE,LA. UNIV ALABAMA,BIRMINGHAM,AL. SENTARA NORFOLK GEN HOSP,NORFOLK,VA. ST MARYS HOSP,SAGINAW,MI. SHADYSIDE HOSP,PITTSBURGH,PA 15232. PRESBYTERIAN MED CTR,PHILADELPHIA,PA 19104. MED CTR DELAWARE,NEWARK,DE. METHODIST HOSP INDIANA,INDIANAPOLIS,IN 46202. MT SINAI MED CTR,NEW YORK,NY 10029. ST JOHNS HOSP,SANTA MONICA,CA. LAVAL HOSP,ST FOY,PQ,CANADA. VIRGINIA BEACH GEN HOSP,VIRGINIA BEACH,VA. OLYMPIA FIELDS HOSP 3,OLYMPIA FIELDS,IL. MCLAREN REG MED CTR,FLINT,MI. RP HOLMES, DR (reprint author), MAYO CLIN & MAYO FDN,CARDIAC CARE UNIT,200 1ST ST SW,ROCHESTER,MN 55905, USA. RI White, Christopher/J-6686-2012; OI White, Christopher/0000-0001-8618-7539; Topol, Eric/0000-0002-1478-4729 NR 37 TC 160 Z9 161 U1 2 U2 4 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0009-7322 J9 CIRCULATION JI Circulation PD APR 1 PY 1995 VL 91 IS 7 BP 1966 EP 1974 PG 9 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA QP542 UT WOS:A1995QP54200014 PM 7895354 ER PT J AU DULLE, KJ STRECKFUSS, TH AF DULLE, KJ STRECKFUSS, TH TI GREENING OF GROUND-WATER SO CIVIL ENGINEERING LA English DT Article AB At the heavily contaminated Bofors-Nobel Superfund site in Michigan, engineers built a $12.4 million, 1.1 mgd continuous-flow plant that establishes an innovative new model for the much-maligned pump and-treat remedial approach. C1 USA,CORPS ENGINEERS,OMAHA,NE. RP DULLE, KJ (reprint author), SVERDRUP ENVIRONM INC,REMEDIAL CONSTRUCT,ST LOUIS,MO, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0885-7024 J9 CIVIL ENG JI Civil Eng. PD APR PY 1995 VL 65 IS 4 BP 62 EP 65 PG 4 WC Engineering, Civil SC Engineering GA QP560 UT WOS:A1995QP56000014 ER PT J AU ARTENSTEIN, AW KIM, JH WILLIAMS, WJ CHUNG, RCY AF ARTENSTEIN, AW KIM, JH WILLIAMS, WJ CHUNG, RCY TI ISOLATED PERIPHERAL TUBERCULOUS LYMPHADENITIS IN ADULTS - CURRENT CLINICAL AND DIAGNOSTIC ISSUES SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID LYMPH-NODE TUBERCULOSIS; HUMAN-IMMUNODEFICIENCY-VIRUS; NEEDLE ASPIRATION CYTOLOGY; EXTRAPULMONARY TUBERCULOSIS; MYCOBACTERIAL LYMPHADENITIS; CERVICAL LYMPHADENOPATHY; UNITED-STATES; MANAGEMENT; EXPERIENCE; INFECTION AB Eight cases of isolated peripheral tuberculous lymphadenitis occurred over a 16-month period at our institution, prompting a literature review to establish the epidemiology, clinical manifestations, and current approaches to diagnosis and treatment of this disorder. It occurs most commonly in young adult women who either are immigrants from areas where tuberculous is endemic or have histories of travel that are suggestive of exposure to Mycobacterium tuberculosis. The disease is indolent and usually presents as a unilateral painless neck mass. Constitutional symptoms are rare, except in individuals infected with the human immunodeficiency virus (HIV). The results of skin testing with purified protein derivative are invariably positive. Excisional biopsy for histopathologic and microbiological evaluations provides the highest diagnostic yield, although fine needle aspiration may be useful for HIV-infected individuals and in areas of the world with a high prevalence of disease. A 6-month course of combination antituberculous therapy is adequate for disease due to susceptible organisms. This infection may be readily diagnosed if suggestive epidemiological and clinical findings lead to expeditious tissue sampling. C1 WALTER REED ARMY MED CTR,INFECT DIS SERV,WASHINGTON,DC. RP ARTENSTEIN, AW (reprint author), WALTER REED ARMY INST RES,DIV RETROVIROL,1600 E GUDE DR,ROCKVILLE,MD 20850, USA. NR 46 TC 57 Z9 60 U1 0 U2 3 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD APR PY 1995 VL 20 IS 4 BP 876 EP 882 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA QP662 UT WOS:A1995QP66200023 PM 7795089 ER PT J AU MELLOR, AM WIEGAND, DA ISOM, KB AF MELLOR, AM WIEGAND, DA ISOM, KB TI HOT-SPOT HISTORIES IN ENERGETIC MATERIALS SO COMBUSTION AND FLAME LA English DT Article ID PROPELLANTS; IGNITION; SENSITIVITY AB Interest in the mechanisms by which hot spots either grow to sustained reaction or are quenched results from the observation that the energy required to ignite a propellant or explosive can be significantly less than that needed to bulk heat a test specimen uniformly to its ignition temperature. This result is independent of the original form of nonthermal energy and has been used to interpret data for shock, impact, friction and electrostatic discharge (ESD) stimuli. We present new flowcharts that include events resulting in hot spot formation and subsequent pathways that lead to sustained reaction or quenching. The mechanism appears capable of categorizing and demonstrating the similarities and differences between hot spot growth to ignition or hot spot quenching, for shock, impact, and ESD stimuli. Sample confinement and temperature and stimulus duration are the independent variables whose roles are particularly clarified in the mechanism. C1 USA,CTR RD & E,DIV ENERGET & WARHEADS,PICATINNY ARSENAL,NJ. HERCULES INC,MAGNA,UT. RP MELLOR, AM (reprint author), VANDERBILT UNIV,DEPT MECH ENGN,BOX 1592,STN B,NASHVILLE,TN 37235, USA. NR 46 TC 12 Z9 19 U1 0 U2 18 PU ELSEVIER SCIENCE PUBL CO INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0010-2180 J9 COMBUST FLAME JI Combust. Flame PD APR PY 1995 VL 101 IS 1-2 BP 26 EP 35 DI 10.1016/0010-2180(94)00171-N PG 10 WC Thermodynamics; Energy & Fuels; Engineering, Multidisciplinary; Engineering, Chemical; Engineering, Mechanical SC Thermodynamics; Energy & Fuels; Engineering GA QV574 UT WOS:A1995QV57400003 ER PT J AU FAIRCHILD, RP AF FAIRCHILD, RP TI NATIONAL DEFENSE SO COMMENTARY LA English DT Letter RP FAIRCHILD, RP (reprint author), USA,NATL GUARD,HAMPTON,VA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER JEWISH COMMITTEE PI NEW YORK PA 165 E 56TH ST, NEW YORK, NY 10022 SN 0010-2601 J9 COMMENTARY JI Commentary PD APR PY 1995 VL 99 IS 4 BP 12 EP 12 PG 1 WC Political Science; Social Issues SC Government & Law; Social Issues GA QN520 UT WOS:A1995QN52000011 ER PT J AU JORDAN, R AF JORDAN, R TI EFFECTS OF CAPILLARY DISCONTINUITIES ON WATER-FLOW AND WATER-RETENTION IN LAYERED SNOWCOVERS SO DEFENCE SCIENCE JOURNAL LA English DT Article ID MELTWATER; SNOW; INFILTRATION; SIMULATION AB The effect of capillary barriers in layered snowcovers has been examined through use of a numerical mass and energy balance model, laboratory tests and field tests. The degree of,suction within the layers has been related to capillary rise and in turn to snow porosity and grain size. The relative importance of permeability and capillary tension on liquid water levels has been examined and it was concluded that capillary discontinuities play a dominant role. It has been shown both theoretically and experimentally that high-over-low suction transitions lead to interruption of water flow vertically and to horizontal movement along discontinuities. Infiltration rates predicted by the numerical model are low because of the omission of finger flow. A more realistic rendering would require a three-dimensional model or incorporate the empirical approach of Marsh and Woo(6). RP JORDAN, R (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 15 TC 7 Z9 7 U1 0 U2 2 PU DEFENCE SCIENTIFIC INFORMATION DOCUMENTATION CENTRE PI DELHI PA METCALFE HOUSE, DELHI 110054, INDIA SN 0011-748X J9 DEFENCE SCI J JI Def. Sci. J. PD APR PY 1995 VL 45 IS 2 BP 79 EP 91 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA RC419 UT WOS:A1995RC41900002 ER PT J AU NESS, JW MARSHALL, TR ARAVICH, PF AF NESS, JW MARSHALL, TR ARAVICH, PF TI EFFECTS OF REARING CONDITION ON ACTIVITY-INDUCED WEIGHT SO DEVELOPMENTAL PSYCHOBIOLOGY LA English DT Article ID ACTIVITY-STRESS ULCER; ACTIVITY-BASED ANOREXIA; RATS; ABNORMALITIES; RESPONSES; EXERCISE; VARIANCE; NERVOSA; MODEL; BRAIN AB This study evaluated the effects of differential rearing conditions on a rat protocol for various human syndromes. Subjects were 26 male Sprague-Dawley rats, 24 days old at the start of the experiment, matched according to weight, acid randomly assigned to an isolation- or group-reared (4 rats/cage) condition. At 60 days of age (273 +/- 13 g), subjects were individually housed in cages allowing access to running wheels. Weight loss was produced through voluntary exercise and restricted food access. Animals in the isolation-reared condition lost weight at a faster rate and had heavier relative thymus weights than those in the group-reared condition. Animals in both conditions ran equivalent distances and ate equivalent amounts of food. The data show that postweaning rearing conditions impact the interpretation of behavioral and physiological outcomes of animal models. The results implicate a shift from maternal regulation of pup physiological and behavioral systems to the broader social niche. (C) 1995 John Wiley & Sons, Inc. C1 CHRISTOPHER NEWPORT UNIV,DEPT PSYCHOL,NEWPORT NEWS,VA. VET AFFAIRS MED CTR,HAMPTON,VA. RP NESS, JW (reprint author), USA,MED RES DETACHMENT,ATTN MCMR-UWB-L-CPT NESS,7914 A DR,BLDG 176,BROOKS AFB,TX 78235, USA. NR 41 TC 7 Z9 7 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0012-1630 J9 DEV PSYCHOBIOL JI Dev. Psychobiol. PD APR PY 1995 VL 28 IS 3 BP 165 EP 173 DI 10.1002/dev.420280304 PG 9 WC Developmental Biology; Psychology SC Developmental Biology; Psychology GA QP357 UT WOS:A1995QP35700003 PM 7796976 ER PT J AU EVERSON, CA REED, HL AF EVERSON, CA REED, HL TI PITUITARY AND PERIPHERAL THYROID-HORMONE RESPONSES TO THYROTROPIN-RELEASING-HORMONE DURING SUSTAINED SLEEP-DEPRIVATION IN FREELY MOVING RATS SO ENDOCRINOLOGY LA English DT Article ID BROWN ADIPOSE-TISSUE; HYPOTHALAMIC RELEASE; TRIIODOTHYRONINE; HYPOTHYROIDISM; THYROXINE; SECRETION; COLD; 5'-DEIODINASE; 3,5,3'-TRIIODOTHYRONINE; THERMOGENESIS AB Sleep deprivation is associated with poor cognitive ability and impaired physical health, but the ways in which the brain and body become compromised are not understood. In sleep-deprived rats, plasma total T-4 and T-3 concentrations decline progressively to 78% and 47% below baseline values, respectively, brown adipose tissue 5'-deiodinase type II activity increases 100-fold, and serum TSH values are unknown. The progressive decline in plasma thyroid hormones is associated with a deep negative energy balance despite normal or increased food intake and malnutrition-like symptoms that eventuate in hypothermia and lethal systemic infections. The purpose of the present experiment was to evaluate the probable causes of the low plasma total T-4 during sleep deprivation by measuring the free hormone concentration to minimize binding irregularities and by challenging the pituitary-thyroid axis with iv TRH to determine both 1) the pituitary release of TSH and 2) the thyroidal response of free T-4 (FT4) and free T-3 (FT3) release to the TSH increment. Sleep-deprived rats were awake 91% of the total time compared with 63% of the total time in yoked control rats and 50% of the total time during the baseline period. Cage control comparison rats were permitted to sleep normally. Sustained sleep deprivation resulted in a decline from baseline in plasma FT4 of 73 +/- 6% and FT3 of 45 +/- 12%, which were similar to the declines in total hormone concentrations observed previously; nonstimulated TSH was unchanged. In the yoked and cage control groups, FT4 also declined, but much less than that of the sleep-deprived group. The relative changes in free compared with total hormone concentrations over the study were also less parallel than those in the sleep-deprived group. The plasma TSH response to TRH was similar in all groups across experimental days. The plasma FT4 and FT3 concentrations in sleep-deprived rats increased after TRH-stimulated TSH release to an extent comparable to control values. Taken together, low basal FT4 and FT3 hormone concentrations and unchanged TSH and thyroidal responses to TRH suggest a pituitary or hypothalamic contribution to the hypothyroxinemia during sleep deprivation. C1 WALTER REED ARMY MED CTR, ENDOCRINE SERV, WASHINGTON, DC 20307 USA. RP EVERSON, CA (reprint author), NIMH, CLIN PSYCHOBIOL BRANCH, BLDG 10, ROOM 4S-239, 10 CTR DR MSC 1390, BETHESDA, MD 20892 USA. NR 51 TC 22 Z9 22 U1 0 U2 3 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0013-7227 EI 1945-7170 J9 ENDOCRINOLOGY JI Endocrinology PD APR PY 1995 VL 136 IS 4 BP 1426 EP 1434 DI 10.1210/en.136.4.1426 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA QP117 UT WOS:A1995QP11700015 PM 7895653 ER PT J AU SIMINI, M WENTSEL, RS CHECKAI, RT PHILLIPS, CT CHESTER, NA MAJOR, MA AMOS, JC AF SIMINI, M WENTSEL, RS CHECKAI, RT PHILLIPS, CT CHESTER, NA MAJOR, MA AMOS, JC TI EVALUATION OF SOIL TOXICITY AT JOLIET ARMY AMMUNITION PLANT SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE ECOLOGICAL RISK ASSESSMENT; EXPLOSIVES; TNT; RDX ID SITES AB Environmental toxicity testing and chemical analyses of soil were performed as part of an ecological risk assessment at the Joliet Army Ammunition Plant (JAAP), Joliet, Illinois. Soils were collected from an area where munitions were loaded, assembled, and packed (area L7, group 1), and from an area where waste explosives were burned on unprotected soil (area L2). Control samples were collected from an adjacent field. Soil toxicity was determined using early seedling growth and vigor tests, earthworm survival and growth tests, and Microtox(R) assays. Relative toxicity of soils was determined within each area based on statistical significance (p = 0.05) of plant and earthworm growth and survival, and the effective concentration at which luminescence of the bacterium Photobacterium phosphoreum was reduced by 50% (EC50) in the Microtox assay. Samples were designated as having high, moderate, or no significant toxicity. Son that had significant toxicity according to at least one test, and representative samples showing no toxicity, were analyzed for munitions via HPLC. Chemical residues found in soils were 2,4,6-trinitrotoluene (TNT); 1,3,5-trinitrobenzene (TNB); 2,4-dinitrotoluene (2,4-DNT); 2,6-dinitrotoluene; 2-amino-4,6-DNT; 4-amino-2,6-DNT; 1,3,5-trinitro-1,3,5-triazine (RDX); and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX). All soils with no significant toxicity were void of these chemicals. However, some soils void of munitions still showed toxicity that may have been caused by elevated levels of heavy metals. Linear regressions of toxicity test results vs. chemical concentrations showed that TNT and TNB accounted for most of the soil toxicity. Lowest-observable-effect concentrations (LOEC) of TNT were determined from these data. This study presents a simple, relatively inexpensive methodology for assessing toxicity of soils containing TNT, RDX, and other contaminants related to munitions production. C1 USA,ERDEC,ABERDEEN PROVING GROUND,MD 21010. USA,CHPPM,FT DETRICK,FREDERICK,MD 21701. RP SIMINI, M (reprint author), GEOCENTERS INC,GUNPOWDER BRANCH,POB 68,ABERDEEN PROVING GROUND,MD 21010, USA. NR 20 TC 84 Z9 86 U1 1 U2 13 PU SETAC PRESS PI PENSACOLA PA 1010 NORTH 12TH AVE, PENSACOLA, FL 32501-3370 SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD APR PY 1995 VL 14 IS 4 BP 623 EP 630 DI 10.1897/1552-8618(1995)14[623:EOSTAJ]2.0.CO;2 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA QN885 UT WOS:A1995QN88500010 ER PT J AU LEITSCHUH, PH ZIMMERMAN, JP UHORCHAK, JM ARCIERO, RA BOWSER, L AF LEITSCHUH, PH ZIMMERMAN, JP UHORCHAK, JM ARCIERO, RA BOWSER, L TI HALLUX FLEXION DEFORMITY SECONDARY TO ENTRAPMENT OF THE FLEXOR HALLUCIS LONGUS TENDON AFTER FIBULAR FRACTURE SO FOOT & ANKLE INTERNATIONAL LA English DT Article AB This article presents a case of entrapment of the flexor hallucis longus tendon after open reduction and internal fixation of a Weber C ankle fracture resulting in interphalangeal joint contracture of the hallux. Pathology involving other tendons at the foot and ankle associated with ankle fractures is reviewed. Other scenarios of flexor hallucis longus pathology are discussed. Flexor hallucis longus anatomy, as related to distal fibular fractures, is outlined, and a recommendation is made to consider flexor hallucis longus entrapment as a cause of hallux dysfunction after open reduction and internal fixation of an ankle fracture. C1 FRANKLIN DELANO ROOSEVELT VET ADM HOSP,MONTROSE,NY. RP LEITSCHUH, PH (reprint author), KELLER ARMY COMMUNITY HOSP,DEPT ORTHOPAED,W POINT,NY 10996, USA. NR 0 TC 18 Z9 21 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1071-1007 J9 FOOT ANKLE INT JI Foot Ankle Int. PD APR PY 1995 VL 16 IS 4 BP 232 EP 235 PG 4 WC Orthopedics SC Orthopedics GA QU335 UT WOS:A1995QU33500013 PM 7787984 ER PT J AU BAMBERGER, PK DUNCAN, MD MOLLOY, M BATZRI, S GOLDBERG, WJ HARMON, JW AF BAMBERGER, PK DUNCAN, MD MOLLOY, M BATZRI, S GOLDBERG, WJ HARMON, JW TI TRANSIENT, DEOXYCHOLATE INDUCED, HYPERCALCEMIA IN HUMAN COLON-CANCER CELLS SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 VET ADM MED CTR,DEPT SURG,WASHINGTON,DC 20422. WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1995 VL 108 IS 4 SU S BP A447 EP A447 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA QT863 UT WOS:A1995QT86301775 ER PT J AU BROWN, WR LE, M REID, R BOEDEKER, E VANHAMONT, J AF BROWN, WR LE, M REID, R BOEDEKER, E VANHAMONT, J TI ORAL IMMUNIZATION STRATEGIES - STUDIES OF VARIABLES IN THE INTESTINAL UPTAKE OF MICROPARTICLES SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. VET ADM MED CTR,DENVER,CO 80220. UNIV COLORADO,MED CTR,DENVER,CO 80202. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1995 VL 108 IS 4 SU S BP A788 EP A788 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA QT863 UT WOS:A1995QT86303141 ER PT J AU CONWELL, D SHAY, S AF CONWELL, D SHAY, S TI POSTURE INFLUENCES REFLUX EVENT (RE) COMPOSITION AS WELL AS RE FREQUENCY DURING FASTING SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. CLEVELAND CLIN EDUC FDN,CLEVELAND,OH 44106. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1995 VL 108 IS 4 SU S BP A75 EP A75 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA QT863 UT WOS:A1995QT86300293 ER PT J AU EGAN, J SALATA, K CREMINS, J KIKENDALL, JW NAIR, P LOHANI, A HERSHEY, J SHARMI, S DAVIS, K WONG, RKH AF EGAN, J SALATA, K CREMINS, J KIKENDALL, JW NAIR, P LOHANI, A HERSHEY, J SHARMI, S DAVIS, K WONG, RKH TI CD45-POSITIVE CELLS IN FECES - A MARKER FOR DISEASE-ACTIVITY IN INFLAMMATORY BOWEL-DISEASE SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DIV CLIN INVEST,GASTROENTEROL SERV,WASHINGTON,DC 20307. USDA,LIPID NUTR LAB,BELTSVILLE,MD 20705. FITZSIMONS ARMY MED CTR,AURORA,CO 80045. NR 0 TC 2 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1995 VL 108 IS 4 SU S BP A814 EP A814 DI 10.1016/0016-5085(95)27567-3 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA QT863 UT WOS:A1995QT86303245 ER PT J AU SJOGREN, MH PITTMAN, P LACHANCE, R HACK, D MAKUCH, R SEE, A MACARTHY, P AF SJOGREN, MH PITTMAN, P LACHANCE, R HACK, D MAKUCH, R SEE, A MACARTHY, P TI HEPATITIS-A VACCINE - AN ACCELERATED DOSE SCHEDULE SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 USAMRIID,FT DETRICK,MD. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1995 VL 108 IS 4 SU S BP A1172 EP A1172 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA QT863 UT WOS:A1995QT86304667 ER PT J AU WONG, PWK BACHINSKI, M MAYDONOVITCH, C SJOGREN, M AF WONG, PWK BACHINSKI, M MAYDONOVITCH, C SJOGREN, M TI APPLICATION OF THE INTERNATIONAL AUTOIMMUNE HEPATITIS GROUP SCORING SYSTEM TO AUTOIMMUNE HEPATITIS AND CHRONIC HEPATITIS-C PATIENTS SO GASTROENTEROLOGY LA English DT Meeting Abstract RP WONG, PWK (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1995 VL 108 IS 4 SU S BP A1200 EP A1200 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA QT863 UT WOS:A1995QT86304778 ER PT J AU LAZAS, D MOSES, F WONG, RKH AF LAZAS, D MOSES, F WONG, RKH TI VIDEOENDOSCOPIC ANOSCOPY - AN ADAPTATION TO THE MODERN-ERA SO GASTROINTESTINAL ENDOSCOPY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD APR PY 1995 VL 41 IS 4 BP 307 EP 307 DI 10.1016/S0016-5107(05)80082-3 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA QT419 UT WOS:A1995QT41900046 ER PT J AU LAZAS, D KIKENDALL, JW WONG, R AF LAZAS, D KIKENDALL, JW WONG, R TI ESOPHAGEAL STRICTURE IN A PATIENT WITH EPIDERMOLYSIS-BULLOSA ACQUISITA - ENDOSCOPIC AND MEDICAL-MANAGEMENT SO GASTROINTESTINAL ENDOSCOPY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD APR PY 1995 VL 41 IS 4 BP 354 EP 354 DI 10.1016/S0016-5107(05)80270-6 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA QT419 UT WOS:A1995QT41900234 ER PT J AU ZYBURA, MF JONES, JR JONES, SH TAIT, GB AF ZYBURA, MF JONES, JR JONES, SH TAIT, GB TI SIMULATION OF 100-300-GHZ SOLID-STATE HARMONIC SOURCES SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article; Proceedings Paper CT 5th International Symposium on Space Terahertz Technology CY MAY, 1994 CL UNIV MICHIGAN, ANN ARBOR, MI HO UNIV MICHIGAN ID SCHOTTKY-BARRIER DIODES; BOUNDARY-CONDITION AB Accurate and efficient simulations of the large-signal time-dependent characteristics of second-harmonic Transferred Electron Oscillators (TEO's) and Heterostructure Barrier Varactor (HBV) frequency triplers have been obtained, This is accomplished by using a novel and efficient harmonic-balance circuit analysis technique which facilitates the integration of physics-based hydrodynamic device simulators, The integrated hydrodynamic device/harmonic-balance circuit simulators allow TEO and HBV circuits to be co-designed from both a device and a circuit point of view, Comparisons have been made with published experimental data for both TEO's and HBV's, For TEO's, excellent correlation has been obtained at 140 GHz and 188 GHz in second-harmonic operation. Excellent correlation has also been obtained for HBV frequency triplers operating near 200 GHz, For HBV's, both a lumped quasi-static equivalent circuit model and the hydrodynamic device simulator have been linked to the harmonic-balance circuit simulator. This comparison illustrates the importance of representing active devices with physics-based numerical device models rather than analytical device models. C1 US MIL ACAD,DEPT ELECT ENGN & COMP SCI,W POINT,NY 10996. RP ZYBURA, MF (reprint author), UNIV VIRGINIA,DEPT ELECT ENGN,CHARLOTTESVILLE,VA 22903, USA. NR 15 TC 9 Z9 9 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD APR PY 1995 VL 43 IS 4 BP 955 EP 961 DI 10.1109/22.375260 PN 2 PG 7 WC Engineering, Electrical & Electronic SC Engineering GA QT617 UT WOS:A1995QT61700007 ER PT J AU STILES, BG KRAKAUER, T BONVENTRE, PF AF STILES, BG KRAKAUER, T BONVENTRE, PF TI BIOLOGICAL-ACTIVITY OF TOXIC SHOCK SYNDROME TOXIN-1 AND A SITE-DIRECTED MUTANT, H135A, IN A LIPOPOLYSACCHARIDE-POTENTIATED MOUSE LETHALITY MODEL SO INFECTION AND IMMUNITY LA English DT Article ID STAPHYLOCOCCAL ENTEROTOXIN-B; TUMOR-NECROSIS-FACTOR; CLASS-II MOLECULES; STREPTOCOCCAL PYROGENIC TOXINS; T-CELLS; MONOCLONAL-ANTIBODY; COMMON ANTIBODIES; GAMMA-INTERFERON; HLA-DR; ENDOTOXIN AB A recombinant of toxic shock syndrome toxin 1 (TSST-1) which contains a single histidine-to-alanine mutation at residue 135 (H135A) was analyzed for toxicity and vaccine potential in a lipopolysaccharide (LPS)-potentiated mouse lethality model. The 50% lethal dose (LD(50)) of TSST-1 in BALB/c mice was 47.2 mu/kg, but H135A was not lethal when tested at a dose equivalent to 10 LD(50)s of TSST-1. Levels of tumor necrosis factor (TNF) and gamma interferon (IFN-gamma) in serum were, respectively, 10- and 50 fold higher in LPS-potentiated mice injected with 15 LD(50)s of TSST-1 than in mice given H135A. Mice injected with only TSST-1 did not have elevated levels of TNF or IFN-gamma in serum, while H135A plus LPS or LPS alone elicited identical, yet very low, levels of TNF and IFN-gamma. An enzyme-linked immunosorbent assay of H135A and TSST-1 with anti-TSST-1 serum yielded very similar dose-response curves, which strongly suggests that H135A serologically and conformationally resembles the native toxin. Mice immunized with H135A developed anti bodies that recognized TSST-1 in an enzyme-linked immunosorbent assay and afforded protection against a 15-LD(50) challenge of TSST-1 plus LPS. The pooled sera of mice immunized with either TSST-1 or H135A also prevented lymphocyte proliferation due to TSST-1. C1 USA,MED RES INST INFECT DIS,DIV APPL RES,FREDERICK,MD 21702. UNIV CINCINNATI,DEPT MOLEC GENET BIOCHEM & MICROBIOL,CINCINNATI,OH 45267. RP STILES, BG (reprint author), USA,MED RES INST INFECT DIS,DIV TOXICOL,FREDERICK,MD 21702, USA. NR 69 TC 31 Z9 32 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD APR PY 1995 VL 63 IS 4 BP 1229 EP 1234 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA QP134 UT WOS:A1995QP13400014 PM 7890377 ER PT J AU FORTIER, AH LEIBY, DA NARAYANAN, RB ASAFOADJEI, E CRAWFORD, RM NACY, CA MELTZER, MS AF FORTIER, AH LEIBY, DA NARAYANAN, RB ASAFOADJEI, E CRAWFORD, RM NACY, CA MELTZER, MS TI GROWTH OF FRANCISELLA-TULARENSIS LVS IN MACROPHAGES - THE ACIDIC INTRACELLULAR COMPARTMENT PROVIDES ESSENTIAL IRON REQUIRED FOR GROWTH SO INFECTION AND IMMUNITY LA English DT Article ID SALMONELLA-TYPHIMURIUM; EXPERIMENTAL-INFECTION; LEISHMANIA-DONOVANI; SHIGELLA-FLEXNERI; VIRULENCE FACTOR; PARASITE; CELLS; SUSCEPTIBILITY; MULTIPLICATION; IDENTIFICATION AB Murine macrophages supported exponential intracellular growth of Francisella tularensis LVS in vitro with a doubling time of 4 to 6 h, LVS was internalized and remained in a vacuolar compartment throughout its growth cycle, The importance of endosome acidification to intracellular growth of this bacterium was assessed by treatment of LVS-infected macrophages with several different lysosomotropic agents (chloroquine, NH4Cl, and ouabain), Regardless of the agent used or its mechanism of action, macrophages treated with agents that blocked endosome acidification no longer supported replication of LVS, Over several experiments for each lysosomotropic agent, the number of CFU of LVS recovered from treated macrophage cultures was equivalent to the input inoculum (approximately 10(4) CFU) at 72 h, In contrast, over 10(8) CFU was consistently recovered from untreated cultures, Pretreatment of macrophages with these endosome acidification inhibitors did not alter their ingestion of bacteria. Further, the effects of the inhibitors were completely reversible: inhibitor-pretreated LVS-infected macrophages washed free of the agent and cultured in medium fully supported LVS growth over 72 h, Endosome acidification is an important cellular event essential for release of iron from transferrin, The growth-inhibitory effects of both chloroquine and NH4Cl were completely reversed by addition of ferric PPi, a transferrin-independent iron source, at a neutral pH but not by addition of excess holotransferrin, Thus, intracellular localization in an acidic vesicle which facilitates the availability of iron essential for Francisella growth is a survival tactic of this bacterium, and iron depletion is one mechanism that macrophages use to inhibit its growth. C1 WALTER REED ARMY INST RES,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DEPT PATHOL,WASHINGTON,DC 20307. NR 33 TC 119 Z9 119 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD APR PY 1995 VL 63 IS 4 BP 1478 EP 1483 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA QP134 UT WOS:A1995QP13400053 PM 7890413 ER PT J AU DURKOT, MJ DEGARAVILLA, L CARETTI, D FRANCESCONI, R AF DURKOT, MJ DEGARAVILLA, L CARETTI, D FRANCESCONI, R TI THE EFFECTS OF DICHLOROACETATE ON LACTATE ACCUMULATION AND ENDURANCE IN AN EXERCISING RAT MODEL SO INTERNATIONAL JOURNAL OF SPORTS MEDICINE LA English DT Article DE LACTATE; GLYCOGEN SPARING; PERFORMANCE ENHANCEMENT ID LACTIC-ACIDOSIS; METABOLISM; BLOOD; DOGS; HUMANS; MUSCLE AB Severe lactic acidosis usually accompanies intense endurance exercise. It has been postulated that glycogen depletion working in concert with elevated muscle and plasma lactate levels lead to a concomitant reduction in pH. Their cumulative effect during prolonged physical exertion now leads to muscular fatigue and eventually limit endurance capacity. Therefore in the present study, dichloroacetate (DCA), a compound which enhances the rate of pyruvate oxidation thus reducing lactate formation, has been evaluated in a validated rat model of sub-maximal exercise performance. Male rats (350 g) were divided into two groups (control-saline, IV and DCA 5 mg/kg, IV) and were exercised to exhaustion in a chamber (26 degrees C) on a treadmill (11 m/min, 6 degrees incline). When compared to controls, the DCA-treated rats had longer run times (169 vs 101 min) and a decreased heating rate (0.020 vs 0.029 degrees C/min). In addition, DCA attenuated the increase in plasma lactate (28 vs 40 mg/dl) and significantly reduced both the rate and absolute amount of depletion of muscle glycogen stores. These results suggest that the activation of pyruvate dehydrogenase activity by DCA resulted in a reduction in the rate of glycogenolysis in addition to decreasing lactate accumulation by presumably limiting the availability of pyruvate for conversion to lactate, therefore increasing muscle carbohydrate oxidation via the TCA cycle. Thus DCA effected a significant delay in muscle fatigue. RP DURKOT, MJ (reprint author), USA,ENVIRONM MED RES INST,SGRD UE EPC,NATICK,MA 01760, USA. NR 33 TC 12 Z9 12 U1 1 U2 4 PU GEORG THIEME VERLAG PI STUTTGART PA P O BOX 30 11 20, D-70451 STUTTGART, GERMANY SN 0172-4622 J9 INT J SPORTS MED JI Int. J. Sports Med. PD APR PY 1995 VL 16 IS 3 BP 167 EP 171 DI 10.1055/s-2007-972986 PG 5 WC Sport Sciences SC Sport Sciences GA QW715 UT WOS:A1995QW71500006 PM 7649707 ER PT J AU RACHELE, H TUNICK, A HANSEN, FV AF RACHELE, H TUNICK, A HANSEN, FV TI MARIAH - A SIMILARITY-BASED METHOD FOR DETERMINING WIND, TEMPERATURE, AND HUMIDITY PROFILE STRUCTURE IN THE ATMOSPHERIC SURFACE-LAYER SO JOURNAL OF APPLIED METEOROLOGY LA English DT Note AB Methodology for determining the similarity scaling constants for wind, temperature, and specific humidity from micrometeorological tower data is presented. The equations and the approach for solving them are referred to as MARIAH. The MARIAH solution is much simpler than using the traditional O'KEYPS functions primarily due to the elimination of laborious, iterative schemes required for evaluating the diabatic influence functions, dimensionless lapse rate, and dimensionless wind shear. Examples of output are given to demonstrate the equivalency of MARIAH to O'KEYPS. C1 USA,RES LAB,BATTLEFIELD ENVIRONM DIRECTORATE,WHITE SANDS MISSILE RANGE,NM 88002. NR 20 TC 5 Z9 5 U1 0 U2 0 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 SN 0894-8763 J9 J APPL METEOROL JI J. Appl. Meteorol. PD APR PY 1995 VL 34 IS 4 BP 1000 EP 1005 DI 10.1175/1520-0450(1995)034<1000:MASBMF>2.0.CO;2 PG 6 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA QP501 UT WOS:A1995QP50100020 ER PT J AU MACUCCI, M HESS, K IAFRATE, GJ AF MACUCCI, M HESS, K IAFRATE, GJ TI SIMULATION OF ELECTRONIC-PROPERTIES AND CAPACITANCE OF QUANTUM DOTS SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID MAGNETIC-FIELD; GROUND-STATE; SPECTROSCOPY; ENERGIES; SPECTRA C1 UNIV ILLINOIS,BECKMAN INST,URBANA,IL 61801. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP MACUCCI, M (reprint author), UNIV PISA,DIPARTIMENTO INGN INFORMAZ,VIA DIOTISALVI 2,I-56126 PISA,ITALY. OI Macucci, Massimo/0000-0002-7943-2441 NR 34 TC 62 Z9 62 U1 0 U2 4 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD APR 1 PY 1995 VL 77 IS 7 BP 3267 EP 3276 DI 10.1063/1.358680 PG 10 WC Physics, Applied SC Physics GA QQ609 UT WOS:A1995QQ60900053 ER PT J AU DISHMAN, RK WARREN, JM YOUNGSTEDT, SD YOO, H BUNNELL, BN MOUGEY, EH MEYERHOFF, JL JASOFRIEDMANN, L EVANS, DL AF DISHMAN, RK WARREN, JM YOUNGSTEDT, SD YOO, H BUNNELL, BN MOUGEY, EH MEYERHOFF, JL JASOFRIEDMANN, L EVANS, DL TI ACTIVITY-WHEEL RUNNING ATTENUATES SUPPRESSION OF NATURAL-KILLER-CELL ACTIVITY AFTER FOOTSHOCK SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE LYMPHOCYTES; ADRENOCORTICOTROPIC HORMONE; CORTICOSTERONE; PROLACTIN; RAT MODEL ID NEUROPEPTIDE-Y; PHYSICAL EXERCISE; PERIPHERAL-BLOOD; STRESS; IMMUNOSUPPRESSION; CATECHOLAMINES; CYTOTOXICITY; MODULATION; IMMUNITY; RATS AB We studied whether voluntary running in an activity wheel moderates splenic natural killer (NK) cell cytotoxicity after footshock. Young (50-day) male Fischer 344 rats were randomly assigned to 1) sedentary (n = 16) or 2) activity-wheel (n = 16) groups that each received controllable or uncontrollable footshock on 2 consecutive days or 3) a sedentary home-cage control group (n = 8). Spleens and trunk blood were collected 30 min after the second footshock session. Cytotoxicity was determined by a standard 4-h Cr-51 release assay. Percentages of OX6(+) (B), OX8(+) [T suppressor/cytotoxic (T-s/c)], W3/25(+) (T helper), Thy-1.1 (Pan T cell marker), and 5C6(+) (NK) cells were determined by flow cytometry. Plasma adrenocorticotropic hormone, corticosterone, and prolactin concentrations were measured by radioimmunoassay as modulators of NK activity. Percentage of specific lysis after footshock was similar to 52% of control values for sedentary animals compared with similar to 96% of control values for activity-wheel animals. The groups did not differ in percentages of NK or T-s/c cells. We conclude that voluntary activity-wheel running protects against the suppression of splenic NK activity induced by footshock. This protective effect of wheel running is not explained by an elevation in baseline NK activity; increased percentages of splenic NK or T-s/c cells; or plasma levels of adrenocorticotropic hormone, corticosterone, and prolactin. C1 UNIV GEORGIA,DEPT PSYCHOL,ATHENS,GA 30602. UNIV GEORGIA,DEPT MED MICROBIOL,ATHENS,GA 30602. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT MED NEUROSCI,WASHINGTON,DC 20307. RP DISHMAN, RK (reprint author), UNIV GEORGIA,DEPT EXERCISE SCI,ATHENS,GA 30602, USA. NR 46 TC 48 Z9 52 U1 1 U2 1 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD APR PY 1995 VL 78 IS 4 BP 1547 EP 1554 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA QR546 UT WOS:A1995QR54600046 PM 7615468 ER PT J AU MCLOUGHLIN, TM CARTER, WR KING, CD AF MCLOUGHLIN, TM CARTER, WR KING, CD TI CASE-2 - 1995 - CONTINUOUS RETROGRADE CEREBRAL PERFUSION AS AN ADJUNCT TO BRAIN PROTECTION DURING DEEP HYPOTHERMIC SYSTEMIC CIRCULATORY ARREST SO JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA LA English DT Discussion ID TRANSVERSE AORTIC-ARCH; CARBON-DIOXIDE TENSION; NUCLEAR-MAGNETIC-RESONANCE; LOW-FLOW PERFUSION; CARDIOPULMONARY BYPASS; PROFOUND HYPOTHERMIA; BLOOD-FLOW; GLUCOSE PRETREATMENT; OXYGEN-CONSUMPTION; NEONATAL RAT C1 UNIFORMED SERV UNIV HLTH SCI,WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,PERFUS TECHNOL SECT,BETHESDA,MD. RP MCLOUGHLIN, TM (reprint author), UNIFORMED SERV UNIV HLTH SCI,WALTER REED ARMY MED CTR,DEPT ANESTHESIOL,ANESTHESIA & OPERAT SERV,WASHINGTON,DC 20307, USA. NR 76 TC 7 Z9 7 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 1053-0770 J9 J CARDIOTHOR VASC AN JI J. Cardiothorac. Vasc. Anesth. PD APR PY 1995 VL 9 IS 2 BP 205 EP 214 DI 10.1016/S1053-0770(05)80196-X PG 10 WC Anesthesiology; Cardiac & Cardiovascular Systems; Respiratory System; Peripheral Vascular Disease SC Anesthesiology; Cardiovascular System & Cardiology; Respiratory System GA QQ797 UT WOS:A1995QQ79700018 PM 7780080 ER PT J AU SPERLING, LC LUPTON, GP AF SPERLING, LC LUPTON, GP TI PERSPECTIVES IN DERMATOPATHOLOGY - HISTOPATHOLOGY OF NON-SCARRING ALOPECIA SO JOURNAL OF CUTANEOUS PATHOLOGY LA English DT Article ID LOOSE ANAGEN HAIR; MALE-PATTERN ALOPECIA; ANDROGENETIC ALOPECIA; HUMAN SCALP; TRICHOTILLOMANIA; ANATOMY; AREATA; PATHOLOGY; MINOXIDIL; BALDNESS C1 ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306. RP SPERLING, LC (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 46 TC 67 Z9 69 U1 1 U2 1 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0303-6987 J9 J CUTAN PATHOL JI J. Cutan. Pathol. PD APR PY 1995 VL 22 IS 2 BP 97 EP 114 DI 10.1111/j.1600-0560.1995.tb01391.x PG 18 WC Dermatology; Pathology SC Dermatology; Pathology GA QT968 UT WOS:A1995QT96800001 PM 7560359 ER PT J AU JARVIS, MS OSTERGREN, WJ SMITH, B AF JARVIS, MS OSTERGREN, WJ SMITH, B TI THE APPLICABILITY OF ELECTRICALLY DRIVEN ACCESSORIES FOR TURBOSHAFT ENGINES SO JOURNAL OF ENGINEERING FOR GAS TURBINES AND POWER-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT 38th International Gas Turbine and Aeroengine Congress and Exposition CY MAY 24-27, 1993 CL CINCINNATI, OH SP INT GAS TURBINE INST AB Improved electrical power generation and actuation systems offer new design approaches for performing the engine control and accessory functions in helicopter propulsion systems. Present helicopter technology utilizes turboshaft engines with mechanically driven accessories. These accessories perform the functions of starting, fuel and lube pumping, variable stator actuation, and inlet particle separation. This paper discusses the applicability of replacing the mechanically driven accessories with their electrically driven counterparts. An electric accessory system is defined, which includes a switched reluctance starter/generator and its associated control unit; an electric pumping and actuation system; and the engine mounting for the starter/gener ator. A comparison between the mechanically and electrically driven accessory systems is performed on the basis of cost, weight, and reliability. Experience to date with switched reluctance machines and electrically driven turboshaft accessory systems is summarized. The benefits of electrically driven accessories are shown and recommendations for future activity for this important technology are discussed. C1 USA,AVIAT & TROOP COMMAND,AVIAT APPL TECHNOL DIRECTORATE,FT EUSTIS,VA 23604. RP JARVIS, MS (reprint author), GE CO,AIRCRAFT ENGINES,LYNN,MA 01910, USA. NR 6 TC 0 Z9 0 U1 0 U2 1 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0742-4795 J9 J ENG GAS TURB POWER JI J. Eng. Gas. Turbines Power-Trans. ASME PD APR PY 1995 VL 117 IS 2 BP 221 EP 226 DI 10.1115/1.2814084 PG 6 WC Engineering, Mechanical SC Engineering GA QW733 UT WOS:A1995QW73300001 ER PT J AU BONACUSE, PJ KALLURI, S AF BONACUSE, PJ KALLURI, S TI ELEVATED-TEMPERATURE AXIAL AND TORSIONAL FATIGUE BEHAVIOR OF HAYNES-188 SO JOURNAL OF ENGINEERING MATERIALS AND TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article AB The results are reported for high-temperature axial and torsional low-cycle fatigue experiments performed at 760 degrees C in air on thin-walled tubular specimens of Haynes 188, a wrought cobalt-base superalloy. Data are also presented for mean coefficient of thermal expansion, elastic modulus, and shear modulus at various temperatures from room to 1000 degrees C, and monotonic and cyclic stress-strain curves in tension and in shear at 760 degrees C. This data set is used to evaluate several multiaxial fatigue life models (most were originally developed for room temperature multiaxial life prediction) including von Mises equivalent strain range (ASME Boiler and Pressure Vessel Code), Manson-Halford, Modified Multiaxiality Factor (proposed in this paper), Modified Smith-Watson-Topper, and Fatemi-Socie-Kurath. At von Mises equivalent strain ranges (the torsional strain range divided by root 3, taking the Poisson's ratio to be 0.5), torsionally strained specimens lasted, on average, factors of 2 to 3 times longer than axially strained specimens. The Modified Multiaxiality Factor approach shows promise as a useful method of estimating torsional fatigue life from axial fatigue data at high temperatures. Several difficulties arose with the specimen geometry and extensometry used in these experiments. Cracking at extensometer probe indentations was a problem at smaller strain ranges. Also, as the largest axial and torsional strain range fatigue tests neared completion, a small amount of specimen buckling was observed. C1 NASA,LEWIS RES CTR,NYMA INC,CLEVELAND,OH 44135. RP BONACUSE, PJ (reprint author), USA,RES LAB,NASA,LEWIS RES CTR,VEHICLE PROPULS DIRECTORATE,CLEVELAND,OH 44135, USA. NR 14 TC 10 Z9 10 U1 3 U2 9 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0094-4289 J9 J ENG MATER-T ASME JI J. Eng. Mater. Technol.-Trans. ASME PD APR PY 1995 VL 117 IS 2 BP 191 EP 199 DI 10.1115/1.2804529 PG 9 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA QW902 UT WOS:A1995QW90200009 ER PT J AU DORTCH, MS HAMLINTILLMAN, DE AF DORTCH, MS HAMLINTILLMAN, DE TI DISAPPEARANCE OF REDUCED MANGANESE IN RESERVOIR TAILWATERS SO JOURNAL OF ENVIRONMENTAL ENGINEERING-ASCE LA English DT Article ID OXIDATION AB Results of field studies conducted downstream of five reservoirs are used to develop an improved understanding of the disappearance of reduced manganese in tailwaters. A first-order removal formulation accurately describes the removal of dissolved manganese versus travel time downstream. Results support the theory that adsorption to the stream bottom is the primary removal mechanism. The first-order removal rate, which varied by an order of magnitude from 0.30 to 4.45 day(-1), is found to be highly correlated to the stream slope, which affects shear velocity. Using observed removal rates, a formulation based on the ratio of the stream-bottom mass-transfer velocity, which depends on bottom-shear velocity, and stream depth is developed for computing the removal-rate coefficient. The formulation also depends on substrate type (i.e., cobble or fine-grain sediments). Dissolved manganese concentrations computed with the developed mathematical model show good agreement with observations. Some questions still remain, such as whether there is an annual acclimation time for manganese removal. RP DORTCH, MS (reprint author), USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 22 TC 4 Z9 4 U1 1 U2 3 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9372 J9 J ENVIRON ENG-ASCE JI J. Environ. Eng.-ASCE PD APR PY 1995 VL 121 IS 4 BP 287 EP 297 DI 10.1061/(ASCE)0733-9372(1995)121:4(287) PG 11 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA QN681 UT WOS:A1995QN68100004 ER PT J AU CERCO, CF AF CERCO, CF TI SIMULATION OF LONG-TERM TRENDS IN CHESAPEAKE BAY EUTROPHICATION SO JOURNAL OF ENVIRONMENTAL ENGINEERING-ASCE LA English DT Article AB A predictive mathematical model was employed to examine trends in Chesapeake Bay eutrophication from 1959 to 1988. The model provided details of processes and substances for which no record existed. The simulation indicated the volume of anoxic water was largest in the decade 1969-78. Since then, anoxic volume has declined. The decline was largely due to hydrodynamic effects. In 1969-78, high runoff caused the Bay to be highly stratified and inhibited oxygen transport to bottom waters, Less runoff in the years 1979-88 diminished stratification and allowed enhanced oxygen transport to bottom waters. When only years of similar stratification were compared, an increase in anoxic volume was noted from the 1959-68 decade to the 1979-88 decade. The increase was associated with increasing nitrogen concentration in runoff from two major tributaries and with increasing chlorophyll concentration in the mainstem Bay. RP CERCO, CF (reprint author), USA,ENGINEER WATERWAYS EXPT STN,MAIL STOP ES-Q,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 11 TC 35 Z9 35 U1 2 U2 3 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9372 J9 J ENVIRON ENG-ASCE JI J. Environ. Eng.-ASCE PD APR PY 1995 VL 121 IS 4 BP 298 EP 310 DI 10.1061/(ASCE)0733-9372(1995)121:4(298) PG 13 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA QN681 UT WOS:A1995QN68100005 ER PT J AU ROY, MJ KROENKE, K HERBERS, JE AF ROY, MJ KROENKE, K HERBERS, JE TI WHEN THE PHYSICIAN LEAVES THE PATIENT - PREDICTORS OF SATISFACTION WITH THE TRANSFER OF CARE IN A PRIMARY-CARE CLINIC SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Article DE PREDICTORS; PATIENT SATISFACTION; TRANSFER OF CARE AB OBJECTIVE: To identify independent predictors of patients' satisfaction with transfer of their care from a departing to a new resident physician. DESIGN: A self-administered questionnaire completed by consecutive patients following up after transfer of their care, and by a randomly selected 50% of patients not returning within three months after transfer. SETTING: An internal medicine clinic in a teaching hospital. PATIENTS: Questionnaires were completed by 376 patients: 237 returning to clinic and 139 (91%) of 152 randomly selected patients who had not returned. Mean age of the patients was 65 years, 52% were men, and they had come to the clinic for a median of four years. RESULTS: 57% of the patients were satisfied with the transfer process, 25% were neutral, and 18% expressed frank dissatisfaction. Of nine variables significantly associated with satisfaction by univariate analysis, stepwise multiple regression identified five independent predictors. Personal notification of the patient by the departing physician was the most powerful determinant, explaining 41% of the variability in satisfaction. Other predictors were whether patients believed their physicians had done everything possible to facilitate transfer, whether the departing physician had provided opportunity for discussion of the transfer, whether this discussion was considered sufficient, and patients' impressions of the institution. CONCLUSIONS: Most of the predictors identified can be influenced by physician behavior, suggesting that physicians should personally notify patients of their departure and provide an opportunity for discussion. This could significantly improve patient satisfaction with the transfer process and, as previous studies suggest, translate into greater compliance with medications and follow-up. RP ROY, MJ (reprint author), WALTER REED ARMY MED CTR,DEPT MED,GULF WAR ILLNESS CTR,WASHINGTON,DC 20307, USA. NR 0 TC 11 Z9 11 U1 0 U2 0 PU BLACKWELL SCIENCE PUBL INC CAMBRIDGE PI CAMBRIDGE PA 238 MAIN ST, CAMBRIDGE, MA 02142 SN 0884-8734 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 1995 VL 10 IS 4 BP 206 EP 210 DI 10.1007/BF02600256 PG 5 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA QT151 UT WOS:A1995QT15100005 PM 7790982 ER PT J AU KLOTZ, FW SCHELLER, LF SEGUIN, MC KUMAR, N MARLETTA, MA GREEN, SJ AZAD, AF AF KLOTZ, FW SCHELLER, LF SEGUIN, MC KUMAR, N MARLETTA, MA GREEN, SJ AZAD, AF TI COLOCALIZATION OF INDUCIBLE-NITRIC OXIDE SYNTHASE AND PLASMODIUM-BERGHEI IN HEPATOCYTES FROM RATS IMMUNIZED WITH IRRADIATED SPOROZOITES SO JOURNAL OF IMMUNOLOGY LA English DT Article ID T-CELLS RECOGNIZE; CIRCUMSPOROZOITE PROTEIN; MALARIA SPOROZOITES; PARASITES AB Both CD8(+) T cells and IFN-gamma (IFN-gamma) are important components in the regulation of inducible-nitric oxide synthase (iNOS) which contribute to liver stage anti-malarial activity in rodents immunized with irradiated sporozoites. IFN-gamma, provided by malaria-specific CD8(+) T cells, stimulates liver cells to produce nitric oxide (NO) for the destruction of infected hepatocytes or the parasite within these cells. To identify the cell source of iNOS in livers from Brown Norway rats challenged with Plasmodium berghei sporozoites, we probed tissue sections with antisera that recognize iNOS and the malarial exoerythrocytic stage parasite. Immunofluorescence analysis of parasitized livers demonstrate that 1) iNOS was found in infected hepatocytes, not Kupffer or endothelial cells; and 2) a higher proportion of infected hepatocytes express iNOS in immunized rats compared with naive animals after challenge. There was no immunoreactivity to the iNOS antisera in liver sections of immunized rats 15 h after sporozoite challenge, however, iNOS activity was present in 18% of the infected hepatocytes by 24 h and reached 81% by 31 h. In contrast, <10% of the infected hepatocytes displayed iNOS activity in naive or immune animals 48 h after challenge. We also found a significant decrease in the ability of the immunized animals to express iNOS in response to sporozoite challenge by accelerating the removal of pre-existing irradiated-attenuated parasites from hepatocytes with the antimalarial drug, primaquine. Therefore, induction and maintenance of iNOS activity were dependent on intrahepatic persistence of the irradiated-attenuated parasite. These results suggest that liver-iNOS expression following sporozoite challenge is restricted to the infected hepatocyte and dependent on the presence of the irradiated-attenuated parasite in immune animals. C1 ENTREMED INC,ROCKVILLE,MD 20850. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,DEPT IMMUNOL,WASHINGTON,DC 20307. UNIV MARYLAND,SCH MED,DEPT MICROBIOL & IMMUNOL,BALTIMORE,MD 21201. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT MOLEC MICROBIOL & IMMUNOL,BALTIMORE,MD 21205. UNIV MICHIGAN,COLL PHARM,ANN ARBOR,MI 48109. FU NCI NIH HHS [CA26731]; PHS HHS [A131589] NR 23 TC 55 Z9 57 U1 0 U2 2 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD APR 1 PY 1995 VL 154 IS 7 BP 3391 EP 3395 PG 5 WC Immunology SC Immunology GA QN459 UT WOS:A1995QN45900036 PM 7534796 ER PT J AU NOTTET, HSLM JETT, M FLANAGAN, CR ZHAI, QH PERSIDSKY, Y RIZZINO, A BERNTON, EW GENIS, P BALDWIN, T SCHWARTZ, J LABENZ, CJ GENDELMAN, HE AF NOTTET, HSLM JETT, M FLANAGAN, CR ZHAI, QH PERSIDSKY, Y RIZZINO, A BERNTON, EW GENIS, P BALDWIN, T SCHWARTZ, J LABENZ, CJ GENDELMAN, HE TI A REGULATORY ROLE FOR ASTROCYTES IN HIV-1 ENCEPHALITIS - AN OVEREXPRESSION OF EICOSANOIDS, PLATELET-ACTIVATING-FACTOR, AND TUMOR-NECROSIS-FACTOR-ALPHA BY ACTIVATED HIV-1-INFECTED MONOCYTES IS ATTENUATED BY PRIMARY HUMAN ASTROCYTES SO JOURNAL OF IMMUNOLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; GROWTH-FACTOR-BETA; CENTRAL-NERVOUS-SYSTEM; IMMUNE-DEFICIENCY-SYNDROME; COLONY-STIMULATING FACTOR; AIDS DEMENTIA COMPLEX; ARACHIDONIC-ACID; CULTURED ASTROCYTES; GENE-EXPRESSION; COAT PROTEIN AB HIV-1-infected brain macrophages participate in neurologic dysfunction through their continual secretion of neurotoxins. We previously demonstrated that astroglial cells activate HIV-1-infected monocytes to produce such neurotoxic activities. In this study, the mechanism underlying these monocyte secretory activities was unraveled and found dependent on HIV-1's ability to prime monocytes for activation. LPS stimulation of HIV-1-infected monocytes resulted in an overexpression of eicosanoids, platelet-activating factor (PAF), and TNF-alpha. This was dependent on the level of HIV-1 infection and monocyte stimulation. Cell to cell interactions between activated virus-infected monocytes and primary human astrocytes reduced monocyte secretions. The capacity of astrocytes to deactivate monocytes was, notably, TGF-beta independent. Although astrocytes constitutively produced latent TGF-beta 2, HIV-1-infected monocytes neither affected TGF-beta 2 production nor converted it into a bioactive molecule. Furthermore, addition of rTGF-beta 1 or rTGF-beta 2 or its Abs to LPS-stimulated monocyte-astrocyte mixtures had no effect on monokine production. In contrast, addition of rIL-10 to LPS-stimulated monocytes produced a dose-dependent decrease in TNF-alpha. IL-10 mRNAs were detected in monocytes, but not astrocytes, following LPS treatment. These results suggest that macrophage activation, a major component of HIV-1 infection in the brain, precipitates neuronal injury by causing virus-infected cells to synthesize neurotoxins. The neurotoxins produced by monocytes are then regulated by astrocytes. Astrocytes therefore, can play either positive or negative roles for disease depending on prior macrophage activation. These findings begin to unravel the cellular control mechanisms that influence cognitive and motor dysfunctions in HIV-1-infected individuals. C1 UNIV NEBRASKA,MED CTR,DEPT MED,OMAHA,NE 68198. UNIV NEBRASKA,MED CTR,EPPLEY INST RES CANC & ALLIED DIS,OMAHA,NE 68198. CREIGHTON UNIV,OMAHA,NE 68131. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT MOLEC PATHOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. SCHERING PLOUGH CORP,RES INST,KENILWORTH,NJ 07033. RP NOTTET, HSLM (reprint author), UNIV NEBRASKA,MED CTR,DEPT PATHOL & MICROBIOL,VIRAL PATHOGENESIS LAB,600 S 42ND ST,OMAHA,NE 68198, USA. FU NHLBI NIH HHS [P01 HL43628-05]; NINDS NIH HHS [P01 NS31492-01] NR 89 TC 116 Z9 120 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD APR 1 PY 1995 VL 154 IS 7 BP 3567 EP 3581 PG 15 WC Immunology SC Immunology GA QN459 UT WOS:A1995QN45900055 PM 7897236 ER PT J AU ARTENSTEIN, AW VANCOTT, TC MASCOLA, JR CARR, JK HEGERICH, PA GAYWEE, J SANDERSBUELL, E ROBB, ML DAYHOFF, DE THITIVICHIANLERT, S NITAYAPHAN, S MCNEIL, JG BIRX, DL MICHAEL, RA BURKE, DS MCCUTCHAN, FE AF ARTENSTEIN, AW VANCOTT, TC MASCOLA, JR CARR, JK HEGERICH, PA GAYWEE, J SANDERSBUELL, E ROBB, ML DAYHOFF, DE THITIVICHIANLERT, S NITAYAPHAN, S MCNEIL, JG BIRX, DL MICHAEL, RA BURKE, DS MCCUTCHAN, FE TI DUAL INFECTION WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 OF DISTINCT ENVELOPE SUBTYPES IN HUMANS SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID HTLV-III/LAV; HIV TYPE-1; THAILAND; INVIVO; AIDS; SUPERINFECTION; GENOTYPES; VARIANTS; SEQUENCE; RISK AB Multiple genetic subtypes of human immunodeficiency virus type 1 (HIV-1) have been identified among internationally collected isolates. The HIV-1 epidemic in Thailand is largely due to B and E subtypes of virus. Dual infection with distinct HIV-1 subtypes would suggest that antiviral immunity evoked by one subtype can be incompletely protective against a second. Polymerase chain reaction typing and serologic typing were used to screen a panel of specimens from HIV-1-infected subjects in Thailand. Two persons simultaneously harbored HIV-1 of env subtypes B and E, and this was confirmed by colony hybridization with subtype-specific probes and nucleotide sequence analysis of a 630-bp fragment of gp120 from multiple molecular clones. In addition, both subtypes were identified in cocultured peripheral blood mononuclear cells from 1 individual. These data provide the first evidence of dual HIV-1 infection in humans and reinforce the need for polyvalent vaccines. C1 HENRY M JACKSON FDN,ROCKVILLE,MD. ARMED FORCES RES INST MED SCI,DEPT RETROVIROL,BANGKOK 10400,THAILAND. RP ARTENSTEIN, AW (reprint author), WALTER REED ARMY INST RES,DIV RETROVIROL,1600 E GUDE DR,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 NR 31 TC 145 Z9 145 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD APR PY 1995 VL 171 IS 4 BP 805 EP 810 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA QP912 UT WOS:A1995QP91200007 PM 7706806 ER PT J AU GAMBEL, JM DEFRAITES, R HOKE, C BROWN, A SANCHEZ, J KARABATSOS, N TSAI, T MESCHIEVITZ, C AF GAMBEL, JM DEFRAITES, R HOKE, C BROWN, A SANCHEZ, J KARABATSOS, N TSAI, T MESCHIEVITZ, C TI JAPANESE ENCEPHALITIS VACCINE - PERSISTENCE OF ANTIBODY UP TO 3 YEARS AFTER A 3-DOSE PRIMARY SERIES SO JOURNAL OF INFECTIOUS DISEASES LA English DT Letter ID NEUTRALIZATION C1 CTR DIS CONTROL & PREVENT,ATLANTA,GA 30341. CONNAUGHT LABS INC,SWIFTWATER,PA 18370. RP GAMBEL, JM (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV PREVENT MED,WASHINGTON,DC 20307, USA. NR 3 TC 24 Z9 26 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD APR PY 1995 VL 171 IS 4 BP 1074 EP 1074 PG 1 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA QP912 UT WOS:A1995QP91200062 PM 7706798 ER PT J AU VANBREEMEN, RB JIANG, O TIDWELL, RR HALL, JE BREWER, TG AF VANBREEMEN, RB JIANG, O TIDWELL, RR HALL, JE BREWER, TG TI FAST-ATOM-BOMBARDMENT TANDEM MASS-SPECTROMETRY OF THE ANTIPARASITIC AGENT PENTAMIDINE AND ITS OXYGENATED METABOLITES SO JOURNAL OF MASS SPECTROMETRY LA English DT Article ID PNEUMOCYSTIS-CARINII PNEUMONIA; HYDROXYLATION; ASSAY AB Although pentamidine (1,5-bis(4'-amidinophenoxy)pentane) is currently in use for the treatment of a variety of parasitic infections, including acquired immune deficiency syndrome-related Pneumocystis carinii pneumonia, its metabolism is still under investigation. Positive-ion fast atom bombardment mass spectrometry was used with high-energy collision-activated dissociation (CAD) and linked scanning at constant BIE to obtain tandem mass spectra of protonated molecules of pentamidine and seven synthetic oxygenated derivatives, which are known metabolites of pentamidine. Charge-initiated fragmentation produced abundant fragment ions of m/z 120 and 137 and loss of neutral ammonia from the protonated analyte that characterized the amidinophenoxy group. The structures of isomeric 2-hydroxypentamidine, 3-hydroxypentamidine and N-hydroxypeotamidine could be distinguished based on charge-remote fragmentation that produced a series of fragment ions of the pentyl chain and permitted the exact location of the hydroxyl group in each molecule to be determined Next, tandem mass spectra were obtained and the charge-initiated and charge-remote fragmentation discussed for four other metabolites of pentamidine, including N,N'-dihydroxypentamidine, 5-(4'-amidinophenoxy)pentanoic acid, 5-(4'-amidinophenoxy) pentan-1-ol, and p-hydroxybenzamidine. Finally, tandem mass spectrometry was used to identify pentamidine and three pentamidine metabolites contained in high-performance liquid chromatographic (HPLC) fractions from rat Liver perfusate and rat urine following treatment with pentamidine. Pentamidine metabolites identified in rat urine sad liver perfusate using mass spectrometry and HPLC retention times included 2-hydroxypentamidine, 3-hydroxypentamidine and 5-(4'-amidinophenoxy)pentanoic acid. C1 UNIV N CAROLINA,DEPT PATHOL,CHAPEL HILL,NC 27599. UNIV N CAROLINA,DEPT EPIDEMIOL,CHAPEL HILL,NC 27599. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. RP VANBREEMEN, RB (reprint author), UNIV ILLINOIS,COLL PHARM,DEPT MED CHEM & PHARMACOGNOSY,CHICAGO,IL 60612, USA. NR 16 TC 3 Z9 3 U1 0 U2 1 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 1076-5174 J9 J MASS SPECTROM JI J. Mass Spectrom. PD APR PY 1995 VL 30 IS 4 BP 549 EP 556 DI 10.1002/jms.1190300405 PG 8 WC Biophysics; Chemistry, Organic; Spectroscopy SC Biophysics; Chemistry; Spectroscopy GA QW160 UT WOS:A1995QW16000004 ER PT J AU MORELOCK, JD AF MORELOCK, JD TI THE LAST ASSAULT - THE BATTLE-OF-THE-BULGE REASSESSED - WHITING,C SO JOURNAL OF MILITARY HISTORY LA English DT Book Review RP MORELOCK, JD (reprint author), COMBAT STUDIES INST,FT LEAVENWORTH,KS, USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU VIRGINIA MILITARY INST PI LEXINGTON PA LEXINGTON, VA 24450 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 1995 VL 59 IS 2 BP 360 EP 360 DI 10.2307/2944605 PG 1 WC History SC History GA QW764 UT WOS:A1995QW76400036 ER PT J AU JENNINGS, BM AF JENNINGS, BM TI NURSING RESEARCH - A TIME FOR REDIRECTION SO JOURNAL OF NURSING ADMINISTRATION LA English DT Article ID ADMINISTRATIVE PRACTICE; CARE C1 MADIGAN ARMY MED CTR,INPATIENT QUAL MANAGEMENT GRP,TACOMA,WA. RP JENNINGS, BM (reprint author), USA,NURSE CORPS,WASHINGTON,DC 20310, USA. NR 29 TC 6 Z9 6 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0002-0443 J9 J NURS ADMIN JI J. Nurs. Adm. PD APR PY 1995 VL 25 IS 4 BP 9 EP 11 DI 10.1097/00005110-199504000-00002 PG 3 WC Nursing SC Nursing GA QR218 UT WOS:A1995QR21800002 PM 7714632 ER PT J AU ARROYO, CM JANNY, SJ AF ARROYO, CM JANNY, SJ TI EPR SPIN-LABEL TECHNIQUE AS AN ANALYTICAL TOOL FOR DETERMINING THE RESISTANCE OF REACTIVE TOPICAL SKIN PROTECTANTS (RTSPS) TO THE BREAKTHROUGH OF VESICANT AGENTS SO JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS LA English DT Article DE EPR; SPIN LABELING; ANTIVESICANT; TOPICAL SKIN PROTECTANT; HALF-MUSTARD GAS; H-MG AB Ointment formulations of reactive topical skin protectants (rTSPs) or topical skin protectants (TSPs) based on perfluorinated polyether material (PFPE, i.e., fomblin RT-15) were prepared and spin labeled. Four N-oxyl-4-4'-dimethyloxazolidine derivatives of stearic acid, 5-NS, 7-NS, 12-NS, and 16-NS, were used as spin probes. The spin-labeled vehicle, fomblin-RT-15, and vehicle containing chloroamide (S-330, an antivesicant) were exposed to various concentrations of half-mustard gas. The order parameter (S) was dependent on the depth of penetration of the paramagnetic group into the vehicle (fomblin) and on the chemical composition of the reactive antivesicant under investigation. The net change of the viscosity of the vehicle and the chemical composition were seen to affect the penetration profile. This will provide a useful in vitro screening technique to develop antivesicant TSPs. RP ARROYO, CM (reprint author), USA,MED RES INST CHEM DEF,ATTN MCMR UV DA DR ARROYO,ABERDEEN PROVING GROUND,MD 21010, USA. NR 4 TC 3 Z9 3 U1 0 U2 1 PU ELSEVIER SCIENCE PUBL CO INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 1056-8719 J9 J PHARMACOL TOXICOL JI J. Pharmacol. Toxicol. Methods PD APR PY 1995 VL 33 IS 2 BP 109 EP 112 DI 10.1016/1056-8719(94)00064-B PG 4 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA QM208 UT WOS:A1995QM20800006 PM 7766917 ER PT J AU MCCAMBRIDGE, MM VOGELGESANG, SA OCKENHOUSE, CF AF MCCAMBRIDGE, MM VOGELGESANG, SA OCKENHOUSE, CF TI LISTERIA-MONOCYTOGENES INFECTION IN A PATIENT TREATED WITH METHOTREXATE FOR RHEUMATOID-ARTHRITIS SO JOURNAL OF RHEUMATOLOGY LA English DT Note DE RHEUMATOID ARTHRITIS; LISTERIA MONOCYTOGENES; METHOTREXATE AB We describe a patient with rheumatoid arthritis who developed bacteremia from Listeria monocytogenes after treatment with low dose oral pulse methotrexate. We discuss possible immunologic mechanisms for susceptibility to Listeria infections. As the elderly population increases with more frequent use of immunosuppressive medications, clinical suspicion must be maintained to correctly diagnose and treat infections such as Listeria. C1 WALTER REED ARMY MED CTR,DEPT MED,RHEUMATOL SERV,WASHINGTON,DC 20307. NR 14 TC 8 Z9 8 U1 0 U2 0 PU J RHEUMATOL PUBL CO PI TORONTO PA 920 YONGE ST, SUITE 115, TORONTO ON M4W 3C7, CANADA SN 0315-162X J9 J RHEUMATOL JI J. Rheumatol. PD APR PY 1995 VL 22 IS 4 BP 786 EP 787 PG 2 WC Rheumatology SC Rheumatology GA QU120 UT WOS:A1995QU12000042 PM 7791185 ER PT J AU FINGER, DR KLIPPLE, GL AF FINGER, DR KLIPPLE, GL TI GYNECOMASTIA FOLLOWING LOW-DOSE METHOTREXATE THERAPY FOR RHEUMATOID-ARTHRITIS SO JOURNAL OF RHEUMATOLOGY LA English DT Letter C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP FINGER, DR (reprint author), WILLIAM BEAUMONT ARMY MED CTR,EL PASO,TX 79920, USA. NR 10 TC 6 Z9 6 U1 0 U2 0 PU J RHEUMATOL PUBL CO PI TORONTO PA 920 YONGE ST, SUITE 115, TORONTO ON M4W 3C7, CANADA SN 0315-162X J9 J RHEUMATOL JI J. Rheumatol. PD APR PY 1995 VL 22 IS 4 BP 796 EP 797 PG 2 WC Rheumatology SC Rheumatology GA QU120 UT WOS:A1995QU12000061 PM 7791195 ER PT J AU ADAMS, SO MALLER, O CARDELLO, AV AF ADAMS, SO MALLER, O CARDELLO, AV TI CONSUMER ACCEPTANCE OF FOODS LOWER IN SODIUM SO JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION LA English DT Article ID DIETARY-SODIUM; BLOOD-PRESSURE; SALT TASTE; REDUCTION; RESTRICTION; CHLORIDE AB Objective To assess the magnitude of sodium reduction that can be made without significantly changing the perception of saltiness and acceptability of a broad range of common food items. Design The investigation was carried out in two phases. Military and civilian volunteers (N=190 in study 1; N=380 in study 2) from the US Army Natick Research, Development and Engineering Center rated the saltiness and acceptability of foods containing differing sodium concentrations. Setting Consumers rated food items in the sensory testing laboratory. Intervention ''Regular'' and ''low-sodium'' entrees were rated for saltiness and acceptability in study 1. Prepared food, commercially prepared food, and beverages containing various concentrations of sodium were rated for saltiness and acceptability in study 2. Statistical analyses performed Results were analyzed using Pearson correlation coefficients, Student's t test, and analysis of variance. Results The perception of saltiness increased as the concentration of sodium increased. Acceptance ratings varied considerably over a broad range of sodium concentrations, which indicates that the relationship was product specific. Results suggest that a reduction of one third or more in added sodium can be made to some foods without significantly affecting consumer acceptance. Applications The sodium content of food can be reduced by consumer-guided food engineering and food preparation. Alterations in food preparation and product formulation, in conjunction with alterations in diet, can be effective methods for reducing sodium consumption. C1 USA, NATICK RES & DEV & ENGN CTR, NATICK, MA 01760 USA. RP GEOCENTERS INC, 190 N MAIN ST, NATICK, MA 01760 USA. NR 34 TC 24 Z9 26 U1 1 U2 8 PU AMER DIETETIC ASSOC PI CHICAGO PA 120 S RIVERSIDE PLZ, STE 2000, CHICAGO, IL 60606-6995 USA SN 0002-8223 J9 J AM DIET ASSOC JI J. Am. Diet. Assoc. PD APR PY 1995 VL 95 IS 4 BP 447 EP 453 DI 10.1016/S0002-8223(95)00120-4 PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA QT197 UT WOS:A1995QT19700014 PM 7699187 ER PT J AU Gorton, SA Poling, DR Dadone, L AF Gorton, SA Poling, DR Dadone, L TI Laser velocimetry and blade pressure measurements of a blade-vortex interaction SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB An investigation of the flowfield characteristics around a rotor blade during a blade-vortex interaction (BVI) was conducted at the NASA Langley Research Center by the Army's Aeroperformance Division and the Boeing Defense and Space Group, Helicopter Division, during a wind-tunnel test in the 14 by 22-foot Subsonic Tunnel. A two-component laser velocimeter was used to measure the flowfield near the rotor blade, and blade-mounted surface pressure transducers were used to measure the blade pressure during a BVI. This paper presents velocity measurements that indicate the presence of a vortex in the flowfield and blade surface pressures during a BVI. The following conclusions can be made from this investigation: 1) The streamlines and vectors of the induced velocity, when studied in conjunction with the blade surface pressures, indicate how the flowfield is behaving during a BVI. The blade approaches and intersects a vortex, and the vortex slides beneath the blade. 2) The data provide detailed flowfield information for validating computational predictions of BVI and also for evaluating and improving current wake models. Among the options investigated, only the free-wake calculation by TECH-01 indicated any BVI activity in the first quadrant. C1 USA, ATCOM, Hampton, VA USA. Boeing Def & Space Grp, Helicopter Div, Philadelphia, PA USA. RP Gorton, SA (reprint author), USA, ATCOM, Hampton, VA USA. NR 34 TC 3 Z9 3 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD APR PY 1995 VL 40 IS 2 BP 15 EP 23 PG 9 WC Engineering, Aerospace SC Engineering GA V3034 UT WOS:000169111900002 ER PT J AU Ham, JA Gardner, CK Tischler, MB AF Ham, JA Gardner, CK Tischler, MB TI Flight-testing and frequency-domain analysis for rotorcraft handling qualities SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB A demonstration of frequency-domain flight-testing techniques and analysis was performed on a U.S. Army OH-58D helicopter in support of the OH-58D Airworthiness and Flight Characteristics Evaluation and of the Army's development and ongoing review of Aeronautical Design Standard 33C, Handling Qualities Requirements for Military Rotorcraft. Hover and forward flight (60 kn) tests were conducted in I flight hour by Army experimental test pilots. Further processing of the hover data generated a complete database of velocity, angular-rate, and acceleration-frequency responses to control inputs. A joint effort was then undertaken by the Airworthiness Qualification Test Directorate and the U.S. Army Aeroflightdynamics Directorate to derive handling-quality information from the frequency-response database. A significant amount of information could be extracted from the frequency. domain database using a variety of approaches. This report documents numerous results that have been obtained from the simple frequency-domain tests; in many areas, these results provide more insight into the aircraft dynamics that affect handling qualities than do traditional flight tests. The handling-quality results include ADS-33C bandwidth and phase-delay calculations, vibration spectral determinations, transfer-function models to examine single-axis results, and a six-degree-of-freedom fully coupled state-space model. The ability of this model to accurately predict aircraft responses was verified using data from pulse inputs. This report also documents the frequency-sweep flight-test technique and data analysis used to support the tests. C1 Test Directorate, Airworthiness Qualificat, Edwards AFB, CA 93523 USA. USA, Aeroflightdynam Directorate, ATCOM, Ames Res Ctr, Moffett Field, CA USA. RP Ham, JA (reprint author), Test Directorate, Airworthiness Qualificat, Edwards AFB, CA 93523 USA. NR 16 TC 6 Z9 7 U1 0 U2 2 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD APR PY 1995 VL 40 IS 2 BP 28 EP 38 PG 11 WC Engineering, Aerospace SC Engineering GA V3034 UT WOS:000169111900004 ER PT J AU ANDREAS, EL AF ANDREAS, EL TI THE TEMPERATURE OF EVAPORATING SEA SPRAY DROPLETS SO JOURNAL OF THE ATMOSPHERIC SCIENCES LA English DT Article ID AIR AB Evaporating sea spray droplets are often assumed to be at the temperature of a well-ventilated wet-bulb thermometer, T-wet. Although this assumption may be accurate enough in practice, it is incorrect on theoretical grounds. Spray droplets have curved surfaces, they contain dissolved salts, and they may be small enough that the air and water vapor surrounding them do not behave as continuous fluids. Each of these characteristics of aqueous solution droplets can potentially affect vapor exchange at a droplet's surface and, thus, its temperature; but the wet-bulb temperature accounts for none of these. This paper uses a full microphysical model to accurately predict the evaporating temperature, T-ev, of pure and saline droplets to investigate how close T-wet is to this temperature. In general, T-wet is within 0.2 degrees-0.3 degrees C of T-ev for droplets with salinities from 0 to 40 psu when the droplet radius is 10 mu m or greater. When the droplet radius is less than 10 mu m, however, T-wet can underestimate T-ev badly, especially for higher air temperatures. To provide accurate estimates of T-ev quickly, the paper describes an algorithm that predicts T-ev to within 0.3 degrees C of the temperature predicted by the full model for droplets with radii from 0.5 to 500 mu m when air temperatures are from -10 degrees to 30 degrees C, relative humidities are from 80% to 97.5%, and droplet salinities are from 0 to 40 psu. RP ANDREAS, EL (reprint author), USA,COLD REG RES & ENGN LAB,SNOW & ICE BRANCH,72 LYME RD,HANOVER,NH 03755, USA. NR 22 TC 39 Z9 45 U1 1 U2 5 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 SN 0022-4928 J9 J ATMOS SCI JI J. Atmos. Sci. PD APR 1 PY 1995 VL 52 IS 7 BP 852 EP 862 DI 10.1175/1520-0469(1995)052<0852:TTOESS>2.0.CO;2 PG 11 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA QT709 UT WOS:A1995QT70900005 ER PT J AU McPherson, KR Wilson, SW AF McPherson, KR Wilson, SW TI Life history and descriptions of immatures of the dictyopharid planthopper Phylloscelis pallescens (Homoptera: Fulgoroidea) SO JOURNAL OF THE NEW YORK ENTOMOLOGICAL SOCIETY LA English DT Article AB The life history of Phylloscelis pallescens Germar in Missouri is summarized and the egg and nymphs are described and illustrated. P. pallescens is univoltine, has live nymphal instars and apparently overwinters as eggs. This dictyopharid planthopper feeds exclusively on slender mountain mint [Pycnanthemum tenuifolium Schrad. (Lamiaceae)]. Nymphal instars can be separated by body size, number of pit-like sensoria, size of wing pads, metatibia and tarsomere spination, and number of metatarsomeres. RP McPherson, KR (reprint author), WALTER REED ARMY MED CTR,DEPT ENTOMOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307, USA. NR 13 TC 7 Z9 9 U1 0 U2 2 PU NEW YORK ENTOMOLOGICAL SOC INC PI NEW YORK PA C/O AMER MUSEUM NAT HIST 79TH & CENTRAL PARK WEST, NEW YORK, NY 10024 SN 0028-7199 J9 J NEW YORK ENTOMOL S JI J. N.Y. Entomol. Soc. PD APR PY 1995 VL 103 IS 2 BP 170 EP 179 PG 10 WC Entomology SC Entomology GA UU625 UT WOS:A1995UU62500006 ER PT J AU TZENG, JT AF TZENG, JT TI PREDICTIONS AND EXPERIMENTAL-VERIFICATION OF RESIDUAL-STRESSES IN THERMOPLASTIC COMPOSITE CYLINDERS SO JOURNAL OF THERMOPLASTIC COMPOSITE MATERIALS LA English DT Article AB A model was proposed to predict residual stresses in thermoplastic composite cylinders fabricated using in-situ consolidation processes. A series of poly-ether-ketone-ketone (PEKK)-based glass and graphite composite cylinders with various layup constructions were fabricated to verify the residual stress predictions. The resin viscosity and storage modulus of the polymer were measured for analysis. A ''split ring experiment'' shows a fairly reasonable agreement between the predictions and test data from an application point of view. RP TZENG, JT (reprint author), USA,RES LAB,WEAPONS TECHNOL DIRECTORATE,AMSRL,WT,PD,ABERDEEN PROVING GROUND,MD 21005, USA. NR 11 TC 5 Z9 6 U1 1 U2 4 PU TECHNOMIC PUBL CO INC PI LANCASTER PA 851 NEW HOLLAND AVE, BOX 3535, LANCASTER, PA 17604 SN 0892-7057 J9 J THERMOPLAST COMPOS JI J. Thermoplast. Compos. Mater. PD APR PY 1995 VL 8 IS 2 BP 163 EP 179 PG 17 WC Materials Science, Composites SC Materials Science GA RH655 UT WOS:A1995RH65500002 ER PT J AU MCCARROLL, JE URSANO, RJ FULLERTON, CS OATES, GL VENTIS, WL FRIEDMAN, H SHEAN, GL WRIGHT, KM AF MCCARROLL, JE URSANO, RJ FULLERTON, CS OATES, GL VENTIS, WL FRIEDMAN, H SHEAN, GL WRIGHT, KM TI GRUESOMENESS, EMOTIONAL ATTACHMENT, AND PERSONAL THREAT - DIMENSIONS OF THE ANTICIPATED STRESS OF BODY RECOVERY SO JOURNAL OF TRAUMATIC STRESS LA English DT Note DE PSYCHOLOGICAL STRESS; HUMAN REMAINS; MILITARY PSYCHIATRY; MILITARY PSYCHOLOGY; COMBAT; DISASTER AB Previous research has shown that exposure to grotesque death has been associated with posttraumatic stress disorder and higher levels of stress have been associated with mortuary workers who anticipated handling remains than those who did not. Additional research is presented here to further clarify the nature of the anticipated stress of handling the dead. Anticipated stress of handling human remains was rated for 13 different situations by 479 persons (384 men and 95 women) without such experience, but whose job was likely to require it. Factor analysis of their ratings revealed three psychological dimensions: the gruesomeness of the remains, an emotional link between the viewer and the remains, and personal threats to the remains handler. Suggestions for preventive measures, training, and interventions for those who may handle remains are made. C1 UNIV MARYLAND,DEPT SOCIOL,COLLEGE PK,MD 20742. UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,DEPT PSYCHIAT,BETHESDA,MD 20814. COLL WILLIAM & MARY,DEPT PSYCHOL,WILLIAMSBURG,VA 23185. RP MCCARROLL, JE (reprint author), WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307, USA. NR 9 TC 15 Z9 15 U1 1 U2 1 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0894-9867 J9 J TRAUMA STRESS JI J. Trauma Stress PD APR PY 1995 VL 8 IS 2 BP 343 EP 349 DI 10.1007/BF02109569 PG 7 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA QV146 UT WOS:A1995QV14600013 PM 7627448 ER PT J AU COSTABILE, RA AF COSTABILE, RA TI SURGICAL TECHNIQUES FOR MALE FACTOR INFERTILITY SO JOURNAL OF UROLOGY LA English DT Editorial Material RP COSTABILE, RA (reprint author), WALTER REED ARMY MED CTR,DEPT SURG,UROL SERV,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD APR PY 1995 VL 153 IS 4 BP 1159 EP 1159 DI 10.1016/S0022-5347(01)67537-2 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA QL361 UT WOS:A1995QL36100023 PM 7869487 ER PT J AU YASUTOMI, Y KOENIG, S WOODS, RM MADSEN, J WASSEF, NM ALVING, CR KLEIN, HJ NOLAN, TE BOOTS, LJ KESSLER, JA EMINI, EA CONLEY, AJ LETVIN, NL AF YASUTOMI, Y KOENIG, S WOODS, RM MADSEN, J WASSEF, NM ALVING, CR KLEIN, HJ NOLAN, TE BOOTS, LJ KESSLER, JA EMINI, EA CONLEY, AJ LETVIN, NL TI A VACCINE-ELICITED, SINGLE VIRAL EPITOPE-SPECIFIC CYTOTOXIC T-LYMPHOCYTE RESPONSE DOES NOT PROTECT AGAINST INTRAVENOUS, CELL-FREE SIMIAN IMMUNODEFICIENCY VIRUS CHALLENGE SO JOURNAL OF VIROLOGY LA English DT Article ID INFECTED RHESUS-MONKEYS; SYNTHETIC PEPTIDE; GAG; MACAQUES; IMMUNIZATION; RETROVIRUS; DISEASE; AIDS AB Protection against simian immunodeficiency virus (SIV) challenge was assessed in rhesus monkeys with a vaccine-elicited, single SIV epitope-specific cytotoxic T-lymphocyte (CTL) response in the absence of SIV-specific antibody. Strategies were first explored for eliciting an optimal SIV Gag epitope-specific CTL response, These studies were performed in rhesus monkeys expressing the major histocompatibility complex (MHC) class I gene Mamu-A*01, a haplotype associated with a predominant SIV CTL epitope mapped to residues 182 to 190 of the Gag protein (p11C). We demonstrated that a combined modality immunization strategy using a recombinant Mycobacterium bovis BCG-SIV Gag construct for priming, and peptide formulated in liposome for boosting, elicited a greater p11C-specific CTL response than did a single immunization with peptide-liposome alone. Vaccinated and control monkeys were then challenged with cell-free SIVmine by an intravenous route of inoculation. Despite a vigorous p11C-specific CTL response at the time of virus inoculation, all monkeys became infected with SIV. gag gene sequencing of the virus isolated from these monkeys demonstrated that the established viruses had no mutations in the p11C-coding region, Thus, the preexisting CTL response did not select for a viral variant that might escape T-cell immune recognition, These studies demonstrate that a potent SIV-specific CTL response can be elicited by combining live vector and peptide vaccine modalities, However, a single SIV Gag epitope-specific CTL response in the absence of SIV-specific antibody did not provide protection against a cell-free, intravenous SIV challenge. C1 HARVARD UNIV,BETH ISRAEL HOSP,SCH MED,BOSTON,MA 02215. MEDIMMUNE INC,GAITHERSBURG,MD 20878. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. MERCK SHARP & DOHME LTD,RES LABS,W POINT,PA 19486. FU NCI NIH HHS [CA-50139]; NIAID NIH HHS [AI-35351, AI-20729] NR 31 TC 87 Z9 88 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD APR PY 1995 VL 69 IS 4 BP 2279 EP 2284 PG 6 WC Virology SC Virology GA QL683 UT WOS:A1995QL68300036 PM 7884874 ER PT J AU CHANDLER, SK FRASER, JD BUEHLER, DA SEEGAR, JKD AF CHANDLER, SK FRASER, JD BUEHLER, DA SEEGAR, JKD TI PERCH TREES AND SHORELINE DEVELOPMENT AS PREDICTORS OF BALD EAGLE DISTRIBUTION ON CHESAPEAKE BAY SO JOURNAL OF WILDLIFE MANAGEMENT LA English DT Article DE BALD EAGLE; CHESAPEAKE BAY; DEVELOPMENT; HABITAT; HALIAEETUS-LEUCOCEPHALUS; HUMAN DISTURBANCE; LOGISTIC REGRESSION; MARYLAND ID HABITAT USE; RESPONSES AB We studied the influence of shoreline perch trees and human development on bald eagle (Haliaeetus leucocephalus) distribution on the northern Chesapeake Bay. Bald eagle distributions may be determined by available suitable shoreline perch areas. Models based on human development and shoreline habitat variables may alleviate problems associated with classifying bald eagle habitat by identifying characteristics predictive of eagle presence. We observed 2,962 eagles during 36 shoreline surveys and relocated 110 radiomarked eagles 1,350 times during 1985-92. We counted 5,928 suitable (height greater-than-or-equal-to 6.1 m, diam at breast height [dbh] greater-than-or-equal-to 20.0 cm, and shoreline accessibility greater-than-or-equal-to 30-degrees) perch trees in 229, 250- x 50-m segments along shoreline during 1990-91. Shoreline segments used by eagles had more suitable perch trees (x = 30.3 vs. 22.0; P < 0.001) and a larger percentage of forest cover (x = 54.9 vs. 39.4; P < 0.001) than unused segments. Suitable trees on segments with eagle use were closer to water than suitable trees on segments without eagle use (x = 8.4 vs. 17.0 m; P = 0.009). Most segments classified as marsh (66.7%) were unused. Marsh segments had fewer suitable perch trees, less forest cover, and a greater mean distance from water to the nearest suitable perch tree than did other land types (P < 0.001). Developed segments had fewer suitable perch trees, less forest cover, and a shorter distance from water to the nearest suitable perch tree than undeveloped forested segments (P less-than-or-equal-to 0.01). Logistic regression models based on various measures of perch tree abundance and shoreline development correctly predicted eagle use for 65.9-71.0% of segments. C1 USA,CHEM RJES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP CHANDLER, SK (reprint author), VIRGINIA POLYTECH INST & STATE UNIV,DEPT FISHERIES & WILDLIFE SCI,BLACKSBURG,VA 24061, USA. NR 23 TC 16 Z9 16 U1 0 U2 7 PU WILDLIFE SOC PI BETHESDA PA 5410 GROSVENOR LANE, BETHESDA, MD 20814-2197 SN 0022-541X J9 J WILDLIFE MANAGE JI J. Wildl. Manage. PD APR PY 1995 VL 59 IS 2 BP 325 EP 332 DI 10.2307/3808946 PG 8 WC Ecology; Zoology SC Environmental Sciences & Ecology; Zoology GA QT328 UT WOS:A1995QT32800016 ER PT J AU GARDNER, DJ DAVIS, JA WEINA, PJ THEUNE, B AF GARDNER, DJ DAVIS, JA WEINA, PJ THEUNE, B TI COMPARISON OF TRIBROMOETHANOL, KETAMINE ACETYLPROMAZINE, TELAZOL(TM) XYLAZINE, PENTOBARBITAL, AND METHOXYFLURANE ANESTHESIA IN HSD-ICR MICE SO LABORATORY ANIMAL SCIENCE LA English DT Article ID FENTANYL-DROPERIDOL DROPERIDOL; ADULT MALE-RATS; BODY-TEMPERATURE; COMBINATION; DIAZEPAM AB Variation in the duration of surgical anesthesia in mice prompted an evaluation of various commonly used anesthetics, Using biotelemetric technology, we evaluated the effects of six anesthetic regimens (tribromoethanol, ketamine and acetylpromazine in combination, Telazol(TM) and xylazine in two combinations, pentobarbital, and methoxyflurane) on temperature and activity. Six groups of four male HSD:ICR mice received one of the anesthetic regimens or an equivalent volume of saline, Induction time (time from anesthetic administration until righting reflex loss) and duration of anesthesia (loss of response to interdigital toe pinch) were evaluated, Methoxyflurane and both doses of Telazol(TM) combinations resulted in the shortest and most repeatable induction times. None of the mice in the ketamine/acetylpromazine- and pentobarbital-treated groups lost the interdigital toe pinch reflex. Duration of anesthesia was superior in the two Telazol(TM)/xylazine-treated groups, A direct correlation existed between duration of anesthesia and magnitude and duration of temperature reduction, Duration of anesthesia can be used to predict extent of hypothermia. C1 WALTER REED ARMY INST RES,DIV VET MED,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20889. RP GARDNER, DJ (reprint author), US FDA,CTR BIOL EVALUAT & RES,DIV VET SERV,BETHESDA,MD 20892, USA. NR 16 TC 33 Z9 33 U1 0 U2 3 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD APR PY 1995 VL 45 IS 2 BP 199 EP 204 PG 6 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA QU962 UT WOS:A1995QU96200015 PM 7603025 ER PT J AU WITTESJO, B EITREM, R NIKLASSON, B VENE, S MANGIAFICO, JA AF WITTESJO, B EITREM, R NIKLASSON, B VENE, S MANGIAFICO, JA TI JAPANESE ENCEPHALITIS AFTER A 10-DAY HOLIDAY IN BALI SO LANCET LA English DT Letter C1 SWEDISH INST INFECT DIS CONTROL,STOCKHOLM,SWEDEN. USA,MED RES INST INFECT DIS,FT DETRICK,FREDERICK,MD 21702. RP WITTESJO, B (reprint author), CENT HOSP KARLSKRONA,DEPT INFECT DIS,S-37185 KARLSKRONA,SWEDEN. NR 2 TC 41 Z9 43 U1 0 U2 0 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0099-5355 J9 LANCET JI Lancet PD APR 1 PY 1995 VL 345 IS 8953 BP 856 EP 856 DI 10.1016/S0140-6736(95)92990-8 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA QQ195 UT WOS:A1995QQ19500037 PM 7898243 ER PT J AU CASHMAN, TM MURRAY, PM AF CASHMAN, TM MURRAY, PM TI RESPIRATORY PROTECTION IN OCCUPATIONAL-HEALTH UPDATE SO MILITARY MEDICINE LA English DT Article AB Respiratory protection is a complex field involving industrial hygiene, physics, physiology, toxicology, medicine, anthropology, engineering, law, and worksite administration. Although the use of respirators is widespread, they are the least effective and often the most costly method of protecting workers. Preferred methods of protection are engineering controls that eliminate exposure and substitution of the agent for one of lesser toxicity. However, in work situations where alternative methods are not available, a well-designed and well-monitored respiratory protection program can still provide a safe environment for the soldier and civilian worker. With the enactment and enforcement of the Occupational Health and Safety Act, worker protection has gained a much higher priority among employers and health officials. The field is dynamic and some of the medical screening procedures outlined in TB MED 502 (Respiratory Protection) are outdated. Industrial processes and state-of-the-art protective equipment change rapidly. Because certified occupational health physicians and nurses are not always available, health care workers need a fundamental understanding of respiratory protection. RP CASHMAN, TM (reprint author), TRIPLER ARMY MED CTR,PREVENT MED SERV,HONOLULU,HI 96859, USA. NR 0 TC 1 Z9 1 U1 1 U2 3 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 1995 VL 160 IS 4 BP 168 EP 171 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA RC128 UT WOS:A1995RC12800007 PM 7617222 ER PT J AU WEST, IJ CLARK, C AF WEST, IJ CLARK, C TI THE ARMY NURSE CORPS AND OPERATION RESTORE HOPE SO MILITARY MEDICINE LA English DT Article RP WEST, IJ (reprint author), USA,CTR MIL HIST,WASHINGTON,DC 20310, USA. NR 0 TC 8 Z9 8 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 1995 VL 160 IS 4 BP 179 EP 183 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA RC128 UT WOS:A1995RC12800011 PM 7617226 ER PT J AU SHARPS, P BRAUDAWAY, C SAMTER, J AF SHARPS, P BRAUDAWAY, C SAMTER, J TI THE 91C PROGRAM - AUGMENTING THE READINESS OF THE ARMY-RESERVE SO MILITARY MEDICINE LA English DT Article RP SHARPS, P (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20357, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 1995 VL 160 IS 4 BP 203 EP 207 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA RC128 UT WOS:A1995RC12800017 PM 7617232 ER PT J AU JOHNSON, NA MCCLURE, MJ PROTZKO, E FOSMIRE, D AF JOHNSON, NA MCCLURE, MJ PROTZKO, E FOSMIRE, D TI WILDERVANCKS SYNDROME PRESENTING AS HEMIPARESTHESIA SO MILITARY MEDICINE LA English DT Note AB A 41-year-old male presented with recent-onset left hemiparesthesia, described as a ''tingling numbness'' of the upper extremity, torso, and face. History revealed a lifelong horizontal diplopia, neck stiffness, and left-sided hearing loss for 5 months. Examination revealed an ocular exam consistent with Duane's retraction syndrome, clinical and radiographic evidence of congenital fusion of C2 and C3 demonstrative of the Klippel-Feil anomaly, and a sensorineural hearing loss confirmed by audiometry. The diagnosis of Wildervanck's syndrome was made based on this classic triad of findings. A thorough evaluation has not yielded an objective explanation for the episodic hemiparesthesia. We present a patient exhibiting the classic triad of Wildervanck's syndrome, whose presentation is unique because hemiparesthesia has not previously been reported in association with this rare syndrome. RP JOHNSON, NA (reprint author), DWIGHT D EISENHOWER ARMY MED CTR,DEPT FAMILY & COMMUNITY MED,FT GORDON,GA 30905, USA. NR 0 TC 2 Z9 2 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 1995 VL 160 IS 4 BP 208 EP 211 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA RC128 UT WOS:A1995RC12800018 PM 7617233 ER PT J AU BITTERS, DL AF BITTERS, DL TI EFFICIENT CONCENTRATION OF FORCES, OR HOW TO FIGHT OUTNUMBERED AND WIN SO NAVAL RESEARCH LOGISTICS LA English DT Article AB The dramatic outcome of Operation Desert Storm has caused a paradigm shift in military thinking. Traditionally the overriding factor in combat operations has been mission accomplishment, but doctrinal developers now include additional criteria. Though there are many ways to conduct a campaign to assure a military victory, some are costlier than others in terms of casualties. Current thinking requires that the commander have the goal of mission accomplishment with minimum loss of friendly forces. This article explores the principle of efficient force concentration as a means of minimizing losses while defeating an enemy farce, particularly one that is numerically superior. It looks at several attrition mechanisms and considers conditions under which theory suggests defeat of a larger force is and is not possible. It also investigates properties of a measure of effectiveness called force elasticity and argues that this is the proper benchmark for comparing the relative effectiveness of combatants. (C) 1995 John Wiley and Sons, Inc. C1 USN,POSTGRAD SCH,MONTEREY,CA 93943. RP BITTERS, DL (reprint author), USA,COMMAND & GEN STAFF COLL,FT LEAVENWORTH,KS 66027, USA. NR 21 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0894-069X J9 NAV RES LOG JI Nav. Res. Logist. PD APR PY 1995 VL 42 IS 3 BP 397 EP 418 DI 10.1002/1520-6750(199504)42:3<397::AID-NAV3220420306>3.0.CO;2-Q PG 22 WC Operations Research & Management Science SC Operations Research & Management Science GA QM302 UT WOS:A1995QM30200004 ER PT J AU HELMBOLD, RL REHM, AS AF HELMBOLD, RL REHM, AS TI THE INFLUENCE OF THE NUMERICAL STRENGTH OF ENGAGED FORCES IN THEIR CASUALTIES, BY OSIPOV,M SO NAVAL RESEARCH LOGISTICS LA English DT Article RP HELMBOLD, RL (reprint author), USA,CONCEPTS ANAL AGCY,8120 WOODMONT AVE,BETHESDA,MD 20814, USA. NR 14 TC 3 Z9 3 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0894-069X J9 NAV RES LOG JI Nav. Res. Logist. PD APR PY 1995 VL 42 IS 3 BP 435 EP 490 DI 10.1002/1520-6750(199504)42:3<435::AID-NAV3220420308>3.0.CO;2-2 PG 56 WC Operations Research & Management Science SC Operations Research & Management Science GA QM302 UT WOS:A1995QM30200006 ER PT J AU GRAZKO, MA POLO, KB JABBARI, B AF GRAZKO, MA POLO, KB JABBARI, B TI BOTULINUM TOXIN-A FOR SPASTICITY, MUSCLE SPASMS, AND RIGIDITY SO NEUROLOGY LA English DT Article ID DRUG-THERAPY AB We studied the effects of botulinum toxin A in 12 patients with spasticity and in eight patients with rigidity. The study design was a double-blind, placebo-controlled crossover trial with botulinum toxin A versus saline. Using the Ashworth Scale for spasticity and the Unified Parkinson's Disease Rating Scale for rigidity, we gave the patients a tone grade before and 2 weeks after treatment. Improvement in tone by two grades or more was considered clinically significant. In the spasticity group, botulinum toxin A reduced the tone of all patients significantly, improved functionality and nursing care in eight of 12 patients, and alleviated painful spasms in five of five patients. In the rigidity group, muscle tone was decreased in seven of eight patients, functionality improved in four of seven, and joint and muscle pain decreased in four of five. We conclude that botulinum toxin A is effective against the disabling effects of spasticity and rigidity. The treatment was well tolerated. C1 WALTER REED ARMY MED CTR,NEUROL SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT NEUROL,BETHESDA,MD 20814. FT CARSON ARMY COMMUNITY HOSP,FT CARSON,CO. NR 22 TC 153 Z9 159 U1 1 U2 2 PU LITTLE BROWN CO PI BOSTON PA 34 BEACON STREET, BOSTON, MA 02108-1493 SN 0028-3878 J9 NEUROLOGY JI Neurology PD APR PY 1995 VL 45 IS 4 BP 712 EP 717 PG 6 WC Clinical Neurology SC Neurosciences & Neurology GA QT454 UT WOS:A1995QT45400020 PM 7723960 ER PT J AU SHERIDAN, MF BRUNS, AD BURGESS, LPA AF SHERIDAN, MF BRUNS, AD BURGESS, LPA TI HEMIAGENESIS OF THE THYROID-GLAND SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Note ID I-123 RP SHERIDAN, MF (reprint author), TRIPLER ARMY MED CTR,HSHK DSH,DEPT SURG,HONOLULU,HI 96859, USA. NR 14 TC 6 Z9 6 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD APR PY 1995 VL 112 IS 4 BP 621 EP 623 DI 10.1177/019459989511200422 PG 3 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA QR876 UT WOS:A1995QR87600022 PM 7700675 ER PT J AU DEGNAN, BM MCCLELLAN, DR FRANCIS, GL AF DEGNAN, BM MCCLELLAN, DR FRANCIS, GL TI RESULTS OF FINE-NEEDLE ASPIRATION BIOPSY OF THE THYROID IN CHILDREN AND ADOLESCENTS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR, DEPT PEDIAT, WASHINGTON, DC 20307 USA. USUHS, BETHESDA, MD USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1995 VL 37 IS 4 BP A87 EP A87 PN 2 PG 1 WC Pediatrics SC Pediatrics GA QP082 UT WOS:A1995QP08200509 ER PT J AU DRESSEL, MVC IWAMOTO, LM MARINKOVICH, GA LAVALLEE, SL NAKAMURA, KT AF DRESSEL, MVC IWAMOTO, LM MARINKOVICH, GA LAVALLEE, SL NAKAMURA, KT TI ROLE OF HYPEROXIA AND EPITHELIUM ON AIRWAY CONTRACTILITY IN PRETERM GUINEA-PIGS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 UNIV HAWAII, TRIPLER ARMY MED CTR, KAPIOLANI MED CTR, DEPT PEDS, HONOLULU, HI 96822 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1995 VL 37 IS 4 BP A390 EP A390 PN 2 PG 1 WC Pediatrics SC Pediatrics GA QP082 UT WOS:A1995QP08202324 ER PT J AU IWAMOTO, LM WILSON, VL LEWIS, DE NAKAMURA, KT AF IWAMOTO, LM WILSON, VL LEWIS, DE NAKAMURA, KT TI ROLE OF GESTATIONAL-AGE IN COCAINE AND BENZOYLECGONINE RECOVERY FROM MECONIUM AND AMNIOTIC-FLUID IN GUINEA-PIGS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 UNIV HAWAII, KAPIOLANI MED CTR, DEPT PEDIAT, HONOLULU, HI 96822 USA. US DRUG TESTING LABS, CHICAGO, IL USA. TRIPLER ARMY MED CTR, DEPT CLIN INVEST, HONOLULU, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1995 VL 37 IS 4 BP A77 EP A77 PN 2 PG 1 WC Pediatrics SC Pediatrics GA QP082 UT WOS:A1995QP08200447 ER PT J AU PATRINOS, ME RUBIN, BK STENZLER, A BENT, R EASA, D AF PATRINOS, ME RUBIN, BK STENZLER, A BENT, R EASA, D TI MOVEMENT OF MECONIUM IN AN IN-VITRO AIRWAY WITH ASYMMETRIC HIGH-FREQUENCY OSCILLATION (AHFO) SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 UNIV HAWAII, KAPIOLANI MED CTR, TRIPLER ARMY MED CTR, HONOLULU, HI 96822 USA. ST LOUIS UNIV, SCH MED, SENSOR MED GRP, ST LOUIS, MO 63104 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1995 VL 37 IS 4 BP A230 EP A230 PN 2 PG 1 WC Pediatrics SC Pediatrics GA QP082 UT WOS:A1995QP08201364 ER PT J AU SOOD, SL BALARAMAN, V FINN, KC DIMAURO, S UYEHARA, CFT EASA, D AF SOOD, SL BALARAMAN, V FINN, KC DIMAURO, S UYEHARA, CFT EASA, D TI THE SYNTHETIC SURFACTANT, KL4, FUNCTIONS LIKE A BOVINE SURFACTANT SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 UNIV HAWAII, TRIPLER ARMY MED CTR, KAPIOLANI MED CTR, HONOLULU, HI 96822 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1995 VL 37 IS 4 BP A54 EP A54 PN 2 PG 1 WC Pediatrics SC Pediatrics GA QP082 UT WOS:A1995QP08200311 ER PT J AU SCHUSTER, RH GAMBLE, WB HAMRA, ST MANSON, PN AF SCHUSTER, RH GAMBLE, WB HAMRA, ST MANSON, PN TI COMPARISON OF FLAP VASCULAR ANATOMY IN 3 RHYTIDECTOMY TECHNIQUES SO PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Article ID INJECTION TECHNIQUE; FACE; SMAS; TERRITORIES; SURGERY AB The purpose of this study was to examine differences in blood supply to facial flaps created by three rhyditectomy techniques. The techniques chosen for comparison included a two-layer technique, consisting of separate subcutaneous and extended submuscular aponeurotic system (SMAS) dissections, the Composite dissections as described by Hamra, and a subperiosteal dissection. Six cadavers were injected with lead oxide before dissection, and eight were injected after dissection. After allowing the lead oxide to set, the soft tissues were removed from the face. Vascular patterns of the face were interpreted from x-rays taken of the specimens. Results of the injections performed before dissection confirmed contributions of previously described arteries, including the transverse facial, facial, infra-orbital and terminal branches of the ophthalmic. In addition, there are numerous branches that connect these Vessels to each other. The most consistent of these include the masseteric, jugal, submental, labial, angular and nasal arteries. The patterns of communications between these vessels allow for the visualization of three vertically oriented vascular zones, each connected to the nest by choke zones where anastomoses occur. Dissections performed before injection reveal increased filling of the vessels through more of the flap on the Composite side when compared with the two-layered dissection, absence of vessels in the SMAS, and filling across all three zones on the subperiosteal side. We conclude that there are vascular regions in the face connected by anastomotic choke zones. Separate subcutaneous and sub-SMAS dissections interrupt the vascular connection between zones. Arterial continuity is better maintained in the Composite lift and is literally undisturbed in the subperiosteal lift. These findings may help to explain why extreme tension applied to the Composite flap during closure is so well-tolerated and why extended subcutaneous dissection places the skin at risk for ischemic necrosis. Finally, the SMAS may contain a separate vascular supply, but this supply is probably tenuous and easily compromised after extensive dissection. C1 JOHNS HOPKINS MED INST,DIV PLAST & RECONSTRUCT SURG,BALTIMORE,MD 21205. WALTER REED ARMY MED CTR,PLAST & RECONSTRUCT SURG SERV,WASHINGTON,DC 20307. NR 29 TC 25 Z9 27 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0032-1052 J9 PLAST RECONSTR SURG JI Plast. Reconstr. Surg. PD APR PY 1995 VL 95 IS 4 BP 683 EP 690 PG 8 WC Surgery SC Surgery GA QM073 UT WOS:A1995QM07300009 PM 7892312 ER PT J AU WALTERS, WP SUMMERS, RL AF WALTERS, WP SUMMERS, RL TI AN ANALYTICAL MODEL FOR THE PARTICULATION OF A JET FROM A SHAPED CHARGE LINER SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article AB A new model is presented to predict the cumulative breakup time of the jet from a shaped charge liner. The model invokes a plastic instability criterion, kinematic considerations, and a material constitutive equation. Very good agreement of the cumulative breakup time and jet length with experimental data for several copper liner geometries is shown. The results are dependent on the initial strain rate and jet temperature distribution. RP WALTERS, WP (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 15 TC 2 Z9 3 U1 0 U2 4 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD APR PY 1995 VL 20 IS 2 BP 58 EP 63 DI 10.1002/prep.19950200203 PG 6 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA RA866 UT WOS:A1995RA86600002 ER PT J AU SCHEFFER, R CORRENTI, EE MUKHERJEE, S AF SCHEFFER, R CORRENTI, EE MUKHERJEE, S TI HISTORY OF PREMORBID FUNCTIONING AND ITS DETERIORATION IN FIRST EPISODE PSYCHOSIS PATIENTS SO SCHIZOPHRENIA RESEARCH LA English DT Meeting Abstract C1 DD EISENHOWER ARMY MED CTR,DEPT PSYCHIAT & NEUROL,FT GORDON,GA 30905. NR 0 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-9964 J9 SCHIZOPHR RES JI Schizophr. Res. PD APR PY 1995 VL 15 IS 1-2 BP 20 EP 20 DI 10.1016/0920-9964(95)95073-I PG 1 WC Psychiatry SC Psychiatry GA QN952 UT WOS:A1995QN95200054 ER PT J AU SCHEFFER, R MUKHERJEE, S MAHADIK, SP CORRENTI, EE AF SCHEFFER, R MUKHERJEE, S MAHADIK, SP CORRENTI, EE TI EFFECTS OF NEUROLEPTIC TREATMENT ON RBC ACTIVITIES OF ANTIOXIDANT ENZYMES SO SCHIZOPHRENIA RESEARCH LA English DT Meeting Abstract C1 DD EISENHOWER ARMY MED CTR,DEPT PSYCHIAT & NEUROL,FT GORDON,GA 30905. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-9964 J9 SCHIZOPHR RES JI Schizophr. Res. PD APR PY 1995 VL 15 IS 1-2 BP 70 EP 70 DI 10.1016/0920-9964(95)95221-T PG 1 WC Psychiatry SC Psychiatry GA QN952 UT WOS:A1995QN95200198 ER PT J AU BROWN, JS AF BROWN, JS TI THE GEOGRAPHIC CORRELATION OF SCHIZOPHRENIA TO TICKS AND TICK-BORNE ENCEPHALITIS SO SCHIZOPHRENIA RESEARCH LA English DT Meeting Abstract C1 US MIL ACAD,COMMUNITY MENTAL HLTH CLIN,W POINT,NY 10996. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-9964 J9 SCHIZOPHR RES JI Schizophr. Res. PD APR PY 1995 VL 15 IS 1-2 BP 190 EP 190 PG 1 WC Psychiatry SC Psychiatry GA QN952 UT WOS:A1995QN95200559 ER PT J AU ZYBURA, MF JONES, SH TAIT, G DUVA, JM AF ZYBURA, MF JONES, SH TAIT, G DUVA, JM TI EFFICIENT COMPUTER-AIDED-DESIGN OF GAAS AND INP MILLIMETER-WAVE TRANSFERRED ELECTRON DEVICES INCLUDING DETAILED THERMAL-ANALYSIS SO SOLID-STATE ELECTRONICS LA English DT Article ID GUNN-DIODES; SIMULATION; MICROWAVE; POWER; GHZ AB An accurate calculation of the large-signal a.c. behavior with detailed thermal considerations is presented for GaAs and InP transferred electron devices. This is accomplished by sequentially solving the temperature dependent drift and diffusion equations along with a novel heat flow analysis to update the temperature profile in the device. The drift and diffusion equations employ both held and temperature dependent mobility and diffusivity derived from Monte Carlo simulations, and the thermal analysis includes all regions of the device. Simulation results are compared to experimental devices with good agreement. The relationship between the graded active layer doping profiles, device area and device length, with the device temperature, output power and device admittance is clearly illuminated by the temperature dependent large-signal a.c, simulator. For the devices simulated, the complex device admittances are calculated over the range of stable operation and at the maximum power point. C1 UNIV VIRGINIA,DEPT ELECT ENGN,CHARLOTTESVILLE,VA 22903. US MIL ACAD,DEPT ELECT ENGN & COMP SCI,W POINT,NY 10996. UNIV VIRGINIA,DEPT APPL MATH,CHARLOTTESVILLE,VA 22903. NR 21 TC 14 Z9 14 U1 1 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD APR PY 1995 VL 38 IS 4 BP 873 EP 880 DI 10.1016/0038-1101(94)00178-I PG 8 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA QN627 UT WOS:A1995QN62700021 ER PT J AU JOHNSON, JE PEACOCK, MD HAYES, JA MORRIS, MJ ANDERS, GT BLANTON, HM AF JOHNSON, JE PEACOCK, MD HAYES, JA MORRIS, MJ ANDERS, GT BLANTON, HM TI FORCED EXPIRATORY FLOW IS REDUCED BY 100-PERCENT OXYGEN IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY-DISEASE SO SOUTHERN MEDICAL JOURNAL LA English DT Article ID AIRWAY OBSTRUCTION; VALUES; LUNG AB In order to determine the effect of breathing high fractional concentrations of oxygen on forced expiratory flow in individuals with chronic obstructive pulmonary disease (COPD), we studied 18 patients with moderately severe disease. The patients were studied breathing air, 100% oxygen, or a four-gas mixture in a randomized double-blind study design. The four-gas mixture (oxygen 21.0%, argon 48.6%, nitrogen 19.3%, and helium 11.1%)was calculated to have a density and viscosity similar to oxygen. During spirometric testing, breathing oxygen produced a detectable reduction in timed volumes by 1 minute that was sustained at 5 minutes (FEVI reduction 4.9% at 1 minute and 6.3% at 5 minutes), Breathing the gas mixture for 5 minutes resulted in similar reductions in flow. We conclude that high concentrations of oxygen reduce forced expiratory flow in patients with airflow obstruction, an effect probably related to the increased density and viscosity relative to air. This reduction in forced expiratory flow may contribute to the deterioration seen when COPD patients with acute respiratory failure are treated with 100% oxygen. RP JOHNSON, JE (reprint author), BROOKE ARMY MED CTR,PULM DIS CRIT CARE SERV,HSHE-MDP,BLDG 2376,1950 STANLEY RD,FT SAM HOUSTON,TX 78234, USA. NR 28 TC 5 Z9 5 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD APR PY 1995 VL 88 IS 4 BP 443 EP 449 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA QT269 UT WOS:A1995QT26900012 PM 7716598 ER PT J AU WANG, XD KIANG, JG SMALLRIDGE, RC AF WANG, XD KIANG, JG SMALLRIDGE, RC TI IDENTIFICATION OF PROTEIN-KINASE-C AND ITS MULTIPLE ISOFORMS IN FRTL-5 THYROID-CELLS SO THYROID LA English DT Article ID PROMOTING PHORBOL ESTERS; ACTIVATION; GROWTH; DIFFERENTIATION; PROLIFERATION; CULTURE; ACETATE AB Protein kinase C (PKC) has been implicated as an important regulator of signal transduction in the FRTL-5 thyroid cell line, but little is known about its isoforms in this cell line. In the present investigation, we characterized the activation of PKC by measuring the enzyme activity and identifying its isoforms in both cytosol and membrane fractions. Phorbol 12-myristate W-acetate (PMA) was used as a PKC activator in this study. PKC activity assay revealed that PMA (300 nM) induced a rapid translocation from cytosol to membrane within 1 min and led to an almost complete translocation within 15 min. Multiple PKC isoforms were examined by Western blot analysis with specific antibodies against alpha, beta, gamma, delta, epsilon, and zeta isoforms. PKC alpha, delta, epsilon, and zeta were identified in this cell line, but PKC beta and gamma were not. Exposure of the cells to PMA (300 nM) for 5 to 30 min led to the translocation of PKC alpha, delta, and epsilon from the cytosol to the membrane fraction, while PKC zeta was not affected. Treatment with PMA (300 nM) for 24 h resulted in the down-regulation of PKC alpha, delta, and epsilon, but not PKC zeta. This study demonstrates for the first time direct evidence for the activation of PKC, and expression and distribution of its isoforms in FRTL-5 thyroid cells. C1 WALTER REED ARMY MED CTR,DEPT CLIN PHYSIOL,DIV MED,WASHINGTON,DC 20307. NR 26 TC 18 Z9 18 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 1050-7256 J9 THYROID JI Thyroid PD APR PY 1995 VL 5 IS 2 BP 137 EP 140 DI 10.1089/thy.1995.5.137 PG 4 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA QZ364 UT WOS:A1995QZ36400011 PM 7647574 ER PT J AU SMITH, LA OLSON, MA LAFAYE, PJ DOLLY, JO AF SMITH, LA OLSON, MA LAFAYE, PJ DOLLY, JO TI CLONING AND EXPRESSION OF MAMBA TOXINS SO TOXICON LA English DT Article; Proceedings Paper CT 4th International Symposium on Neurotoxins in Neurobiology CY SEP 19-23, 1993 CL BATH, ENGLAND ID AMINO-ACID-SEQUENCE; SNAKE-VENOM TOXINS; POLYMERASE CHAIN-REACTION; K+-CHANNEL PROBE; POTASSIUM CHANNELS; TRYPSIN-INHIBITOR; ALPHA-DENDROTOXIN; MESSENGER-RNA; BINDING-SITES; GREEN MAMBA AB Mamba venoms contain pharmacologically active proteins that interfere with neuromuscular transmission by binding to and altering the normal functioning of neuronal proteins involved, directly or indirectly, with regulating nerve transmission. Of the mamba toxins studied to date, many act on voltage-sensitive K+ channels, nicotinic or muscarinic acetylcholine receptors, or acetylcholinesterase. In an attempt to clone, characterize, and express the genes encoding these toxins, as well as other genes specifying activities not completely elucidated as yet, a cDNA library was constructed from mRNA isolated from the glands of the black mamba. Clones from the library harboring sequences encoding 14 different mamba toxins were isolated and characterized by nucleotide sequence analysis. Genes coding for three proteins, dendrotoxins (DTX) K, I, and E, were expressed as maltose-binding (MBP) fusion proteins in the periplasmic space of Escherichia coli. The DTX(K)-MBP fusion protein was affinity purified, cleaved from its chaperon, and the recombinant DTX(K) purified from MBP. Recombinant DTX(K) was shown to be identical to native DTX(K) in its N-terminal sequence, chromatographic behavior, convulsion-inducing activity, and binding to voltage-activated K+ channels in bovine synaptic membranes. Computer modeling was employed to create three-dimensional structures of DTX(K) and DTX(l) from the X-ray crystal structure of alpha-DTX utilizing both structural and sequence homologies. Comparisons were made between the three toxins, providing a framework for site-directed mutagenesis. C1 INST PASTEUR,HYBRIDOLAB,PARIS,FRANCE. UNIV LONDON IMPERIAL COLL SCI & TECHNOL,DEPT BIOCHEM,LONDON SW7 2AY,ENGLAND. RP SMITH, LA (reprint author), USA,MED RES INST INFECT DIS,DEPT IMMUNOL & MOLEC BIOL,DIV TOXICOL,FT DETRICK,MD 21702, USA. RI Dolly, Oliver/G-1532-2012 OI Dolly, Oliver/0000-0002-0861-5320 NR 51 TC 8 Z9 8 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD APR PY 1995 VL 33 IS 4 BP 459 EP 474 DI 10.1016/0041-0101(94)00193-C PG 16 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA RC096 UT WOS:A1995RC09600007 PM 7570631 ER PT J AU ADLER, M SCOVILL, J PARKER, G LEBEDA, FJ PIOTROWSKI, J DESHPANDE, SS AF ADLER, M SCOVILL, J PARKER, G LEBEDA, FJ PIOTROWSKI, J DESHPANDE, SS TI ANTAGONISM OF BOTULINUM TOXIN-INDUCED MUSCLE WEAKNESS BY 3,4-DIAMINOPYRIDINE IN RAT PHRENIC NERVE-HEMIDIAPHRAGM PREPARATIONS SO TOXICON LA English DT Article; Proceedings Paper CT 4th International Symposium on Neurotoxins in Neurobiology CY SEP 19-23, 1993 CL BATH, ENGLAND ID NEUROTRANSMITTER RELEASE; TETANUS TOXIN; 4-AMINOPYRIDINE; NEUROTOXINS; SYNAPTOBREVIN; CURRENTS; BLOCK AB The effects of the potassium channel inhibitor and putative botulinum toxin antagonist 3,4-diaminopyridine (3,4-DAP) were investigated in vitro on the contractile properties of rat diaphragm muscle. In the presence of 100 pM botulinum neurotoxin A (BoNT/A), twitches elicited by supramaximal nerve stimulation (0.1 Hz) were reduced to approximately 10% of control in 3 hr at 37 degrees C. Addition of 3,4-DAP led to a rapid reversal of the BoNT/A-induced depression of twitch tension. In the presence of 100 mu M 3,4-DAP, antagonism of the BoNT/A-induced blockade began within 30-40 sec and reached 82% of control with a half-time of 6.7 min. The beneficial effect of 3,4-DAP was well maintained and underwent little or no decrement relative to control for at least 8 hr after addition. Application of 1 mu M neostigmine 1 hr after 3,4-DAP led to a further potentiation of twitch tension, but this action lasted for < 20 min. Moreover, neostigmine caused tetanic fade during repetitive stimulation. In contrast to the efficacy of the parent compound, the quaternary derivative of 3,4-DAP, 3,4-diamino-1-methyl pyridinium produced little or no twitch potentiation up to a concentration of 1 mM. The potassium channel blocker, tetraethylammonium, generated a transient potentiation followed by a sustained depression of twitch tensions. It is concluded that 3,4-DAP is of benefit in antagonizing the muscle paralysis following exposure to BoNT/A. Co-application of neostigmine or tetraethylammonium with 3,4-DAP, however, appears to confer no additional benefit. C1 USA,MED RES INST INFECT DIS,DIV TOXINOL,FREDERICK,MD 21701. RP ADLER, M (reprint author), USA,MED RES INST CHEM DEF,DIV PATHOPHYSIOL,NEUROTOXICOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 29 TC 29 Z9 29 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD APR PY 1995 VL 33 IS 4 BP 527 EP 537 DI 10.1016/0041-0101(94)00183-9 PG 11 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA RC096 UT WOS:A1995RC09600014 PM 7570638 ER PT J AU SHERIDAN, RE DESHPANDE, SS AF SHERIDAN, RE DESHPANDE, SS TI INTERACTIONS BETWEEN HEAVY-METAL CHELATORS AND BOTULINUM NEUROTOXINS AT THE MOUSE NEUROMUSCULAR-JUNCTION SO TOXICON LA English DT Article; Proceedings Paper CT 4th International Symposium on Neurotoxins in Neurobiology CY SEP 19-23, 1993 CL BATH, ENGLAND ID TETANUS TOXIN; NEUROTRANSMITTER RELEASE; TRANSMITTER RELEASE; ZINC; INHIBITION; MECHANISM; PROTEIN; NEURONS AB Exposure of isolated mouse hemidiaphragms to botulinum neurotoxins, 0.1 nM BoNT-A or BoNT-B, at 36 degrees C reduced nerve-elicited peak isometric twitch tension to 50% of control values at 55 min (BoNT-A) to 68 min (BoNT-B) after application, Either coincubation of BoNT with the heavy metal chelator TPEN, preincubation with TPEN followed by BoNT, or application of TPEN after BoNT but before neuromuscular block, delayed the onset of muscle failure in a dose-dependent manner by up to five-fold, TPEN doses between 2 and 10 mu M were required to antagonize significantly the muscle block produced by BoNT, and the delay in onset was maximal between 10 and 50 mu M TPEN. Treatment of muscles with a Zn2+-TPEN coordination complex, rather than TPEN alone, eliminated any beneficial effects of TPEN on BoNT intoxication, indicating that these effects were mediated by chelation of Zn2+. Other metal chelators that were not as membrane permeant as TPEN were ineffective in delaying BoNT paralysis, suggesting that TPEN acts by chelating intraterminal Zn2+. In the absence of BoNT, TPEN caused a dose-dependent increase in nerve-elicited twitch tension with a half-maximal concentration at 8 mu M. There was no corresponding change in twitches from direct electrical stimulation of the muscle. After BoNT (A or B serotype) had reduced the muscle twitch by 20 to 70%, however, subsequent application of TPEN rapidly depressed nerve-elicited twitches. The shift from potentiation to depression after BoNT treatment suggests that presynaptic vesicle mobilization and/or release involve Zn2+-dependent enzymes and that BoNTs interact with these enzyme pathways. RP SHERIDAN, RE (reprint author), USA,MED RES INST CHEM DEF,DIV PATHOPHYSIOL,NEUROTOXICOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 19 TC 24 Z9 24 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD APR PY 1995 VL 33 IS 4 BP 539 EP 549 DI 10.1016/0041-0101(94)00185-B PG 11 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA RC096 UT WOS:A1995RC09600015 PM 7570639 ER PT J AU DESHPANDE, SS SHERIDAN, RE ADLER, M AF DESHPANDE, SS SHERIDAN, RE ADLER, M TI A STUDY OF ZINC-DEPENDENT METALLOENDOPEPTIDASE INHIBITORS AS PHARMACOLOGICAL ANTAGONISTS IN BOTULINUM NEUROTOXIN POISONING SO TOXICON LA English DT Article; Proceedings Paper CT 4th International Symposium on Neurotoxins in Neurobiology CY SEP 19-23, 1993 CL BATH, ENGLAND ID NEUROTRANSMITTER RELEASE; TETANUS TOXIN; PROTEASE AB Zinc-dependent metalloprotease inhibitors phosphoramidon, captopril and a peptide hydroxamate were studied as potential pretreatment Compounds by examining their ability to delay the onset or to prolong the time to 50% block of nerve-elicited muscle twitch tension in the mouse phrenic-nerve diaphragm (in vitro at 36 degrees C) after botulinum neurotoxin serotypes A and B (BoNT-A, BoNT-B). Addition of BoNT-A or BoNT-B (1 x 10(-10) M) produced 50% block of the twitch response at 56 +/- 9 min and 76 +/- 4 min, respectively. Preincubation (45 min) of muscles with phosphoramidon (0.2 mM) prolonged the time to 50% block by 15 min in BoNT-B-poisoned muscles with no effect on the time-course of paralysis in BoNT-A exposed muscles, When the same quantities of BoNT-A or BoNT-B (equivalent to 1 x 10(-10) M bath concentration) were preincubated for 2 hr with phosphoramidon (equivalent to 0.2 mM final bath concentration), and the incubation mixture was added to the muscle chamber, the times to 50% block were prolonged by 38 min and 18 min for BoNT-B and BoNT-A, respectively. Preincubation of diaphragms with captopril (up to 10 mM) or peptide hydroxamate (75 mu M) failed to antagonize BoNT-A or BoNT-B-induced neuromuscular block, Among the three metalloprotease inhibitors examined here, only phosphoramidon showed a significant protection against both serotypes of BoNT. A search for better inhibitor compounds specifically tailored to match the active site on BoNT molecule deserves attention. RP DESHPANDE, SS (reprint author), USA,MED RES INST CHEM DEF,DIV PATHOPHYSIOL,NEUROTOXICOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 9 TC 30 Z9 30 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD APR PY 1995 VL 33 IS 4 BP 551 EP 557 DI 10.1016/0041-0101(94)00188-E PG 7 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA RC096 UT WOS:A1995RC09600016 PM 7570640 ER PT J AU LEBEDA, FJ OLSON, MA AF LEBEDA, FJ OLSON, MA TI STRUCTURAL PREDICTIONS OF THE CHANNEL-FORMING REGION OF BOTULINUM NEUROTOXIN HEAVY-CHAIN SO TOXICON LA English DT Article; Proceedings Paper CT 4th International Symposium on Neurotoxins in Neurobiology CY SEP 19-23, 1993 CL BATH, ENGLAND ID PROTEIN SECONDARY STRUCTURE; DIPHTHERIA-TOXIN; MEMBRANES; SEQUENCES; TETANUS; BIOLOGY AB A novel combination of theoretical approaches was exploited to predict which amino acid residues of various botulinum neurotoxin serotypes participate in forming ion channels. Estimates of sequence hydrophobic moments were used initially to identify residues within amphipathic regions in the N-terminal half of the heavy chain. A neural network algorithm was then used to make additional secondary structural predictions for these regions. Together, these approaches predicted a complimentary pattern of four, adjacent amphipathic, possibly transmembrane, regions that may be separated by solvent-exposed loops, Both the hydrophobic moment and the neural net analyses predicted that at least one of these amphipathic segments may be in an extended conformation, These theoretical results are discussed in view of our current knowledge of other transmembrane structures. RP LEBEDA, FJ (reprint author), USA,MED RES INST INFECT DIS,DEPT CELL BIOL & BIOCHEM,DIV TOXINOL,FREDERICK,MD 21702, USA. NR 30 TC 21 Z9 21 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD APR PY 1995 VL 33 IS 4 BP 559 EP 567 DI 10.1016/0041-0101(94)00192-B PG 9 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA RC096 UT WOS:A1995RC09600017 PM 7570641 ER PT J AU HILLNER, BE MCLEOD, DG CRAWFORD, ED BENNETT, CL AF HILLNER, BE MCLEOD, DG CRAWFORD, ED BENNETT, CL TI ESTIMATING THE COST-EFFECTIVENESS OF TOTAL ANDROGEN BLOCKADE WITH FLUTAMIDE IN M1 PROSTATE-CANCER SO UROLOGY LA English DT Article ID DECISION-ANALYSIS; THERAPY; CARCINOMA; TRIALS AB Objectives. Although combined androgen blockade with flutamide plus medical or surgical castration is effective in metastatic prostate cancer, debate exists over whether it is cost effective, Methods. Decision analysis model of hypothetical cohorts of 70-year-old men presenting with metastatic prostate cancer, using a societal perspective, calculated anticipated survival and incremental cost per life-year gained. Time to progression and survival rate were from the Intergroup 0036 trial. Costs were based on Medicare data and wholesale drug pricing, Flutamide was estimated to reduce the relative risk of progressive disease by 25% (range, 0 to 50%). Costs and survival benefits were discounted at a 5% annual rate. Results. In our model for minimal disease, median survival increased from 42.3 to 49.4 months with flutamide and average survival by 5.2 months at an incremental cost of $25,300 per life-year gained. If the efficacy were as high as 50%, the benefit would be 12 months at a cost of $13,700 per life-year gained. At a 10% efficacy, the benefit would be 1.9 months at a cost of $60,900 per life-year gained. For severe disease, the model estimated the median survival increased from 29.5 to 34.3 months with flutamide and average survival by 4.0 months at an incremental cost of $20,000 per life-year gained. At worst-case 10% efficacy, the benefit decreased to 1.5 months at an incremental cost of $47,500 per life-year gained. Total costs for patients treated with an orchiectomy and flutamide compared to leuprolide alone were similar if severe disease was present and actually lowered costs if there was minimal disease. Conclusions. Flutamide has an incremental cost effectiveness more favorable than most accepted therapies. If drug costs are covered under health care reform, flutamide should be initiated and covered for all good performance status patients. C1 UNIFORMED SERV UNIV HLTH SCI,WALTER REED ARMY MED CTR,BETHESDA,MD. UNIV COLORADO,MED CTR,DIV UROL,DENVER,CO. DUKE UNIV,MED CTR,VET AFFAIRS MED CTR,DIV HEMATOL & ONCOL,DURHAM,ENGLAND. RP HILLNER, BE (reprint author), VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT INTERNAL MED,RICHMOND,VA 23219, USA. RI Bennett, Charles/C-2050-2008; Hillner, Bruce/A-6852-2009 NR 25 TC 39 Z9 39 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD APR PY 1995 VL 45 IS 4 BP 633 EP 640 DI 10.1016/S0090-4295(99)80055-7 PG 8 WC Urology & Nephrology SC Urology & Nephrology GA QQ902 UT WOS:A1995QQ90200018 PM 7716844 ER PT J AU CRYZ, SJ QUE, JO CROSS, AS FURER, E AF CRYZ, SJ QUE, JO CROSS, AS FURER, E TI SYNTHESIS AND CHARACTERIZATION OF A POLYVALENT ESCHERICHIA-COLI O-POLYSACCHARIDE TOXIN-A CONJUGATE VACCINE SO VACCINE LA English DT Article DE VACCINE; ESCHERICHIA COLI; CONJUGATES ID PSEUDOMONAS-AERUGINOSA; MONOCLONAL-ANTIBODIES; INFECTION; LIPOPOLYSACCHARIDE; IMMUNOGLOBULIN; BACTEREMIA; ANTIGEN; K1 AB A 12-valent Escherichia coli O-polysaccharide (O-PS)-toxin A conjugate vaccine was formulated Nonpyrogenic, low-molecular-weight O-PS, was derived from lipopolysaccharides (LPS) of the following serotypes: 01, 02, 04, 06, 07, 08, 012 015, 016, 018, 025, and 075. Individual O-PS were covalently coupled to Pseudomonas aeruginosa toxin A using adipic acid dihydrazide as a spacer molecule and carbodiimide as a coupling agent. On a weight basis, the final multivalent vaccine was composed of 43% O-PS and 57% toxin A. The vaccine was nontoxic and nonpyrogenic in standard animal tests. Immunization of rabbits engendered a marked rise (6-74-fold) in anti-LPS immunoglobulin G (IgG) antibody titers. When passively transferred to mice, immune turze rabbit IgG conferred statistically significant (p<0.05) protection against a challenge with 9 of the 12 vaccine serotypes. For two serotypes, although the mortality rate declined by greater than or equal to 50% in the passively immunized versus the control group, the difference did not reach statistical significance. The degree of protection provided by passively transferred IgG was influenced by both the anti-LPS antibody levels in the IgG preparation and the virulence of the challenge strain. Active immunization of mice with either conjugate vaccine or killed E. coli, whole cells did not confer protection. This was most probably due to the fact that these antigens induced a meagre anti-LPS IgG antibody response. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. RP CRYZ, SJ (reprint author), SWISS SERUM & VACCINE INST,POB 2707,CH-3001 BERN,SWITZERLAND. NR 24 TC 13 Z9 16 U1 0 U2 1 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA LINACRE HOUSE JORDAN HILL, OXFORD, OXON, ENGLAND OX2 8DP SN 0264-410X J9 VACCINE JI Vaccine PD APR PY 1995 VL 13 IS 5 BP 449 EP 453 DI 10.1016/0264-410X(94)00009-C PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA QR844 UT WOS:A1995QR84400005 PM 7639013 ER PT J AU CHANH, TC HEWETSON, JF AF CHANH, TC HEWETSON, JF TI PROTECTION AGAINST RICIN INTOXICATION IN-VIVO BY ANTIIDIOTYPE VACCINATION SO VACCINE LA English DT Article ID MONOCLONAL-ANTIBODIES; IMMUNE-RESPONSE; MICE; VIRUS; MODULATION; TOXICITY; CHAIN; CYTOTOXICITY; CARBOHYDRATE; IMMUNIZATION AB A BALB/c murine anti-ricin monoclonal antibody (mAb BG11-G2, IgG(1k)), was recently isolated and shown to passively protect syngeneic mice against ricin intoxication in vivo. New Zealand White rabbit polyclonal anti-idiotype (anti-Id) antibodies were raised to BG11-G2 anti-ricin mAb, and rendered specific by repeated absorption over agarose-normal mouse immunoglobulin (Ig). The absorbed rabbit anti-Id antibodies lost reactivity to normal mouse Ig and to a BALB/c anti-T-2 mycotoxin IgG(1k) mAb (HD11), but remained reactive with BG11-G2 anti-ricin mAb. The rabbit anti-Id inhibited the binding of BG11-G2 mAb to ricin-coated wells, and elicited a specific and protective anti-ricin antibody response in naive BALB/c mice. Whereas all mice vaccinated with a control rabbit anti-Id antibody preparation died from in vivo ricin challenges, mice immunized with the rabbit anti-Id specific for BG11-G2 mAb were protected to various degrees. All mice vaccinated with rabbit anti-Id to BG11-G2 and challenged with ricin doses of 35 and 50 mu g kg(-1) body weight died from the challenge; however, a delay in the elapsed time between ricin administration and death was observed in these mice as compared to that of the control anti-Id-immune mice. Five of seven mice vaccinated with the rabbit anti-Id to BG11-G2 and subsequently challenged in vivo with a ricin dose of 20 mu g kg(-1) body weight survived the lethal in vivo ricin challenge, whereas all the control mice died. The five surviving mice were successively rechallenged with increasing ricin doses of 50, 150, and 500 mu g kg(-1) body weight, respectively, on days 76, 82 and 92 following the first ricin challenge. All five mice survived the subsequent in vivo ricin rechallenges, and remained healthy two months following the last ricin re-challenge, suggesting an anti-Id-induced priming of an enhanced protective immune response to the nominal antigen, ricin. C1 USA,MED RES INST INFECT DIS,DEPT PATHOPHYSIOL,DIV TOXINOL,FREDERICK,MD 20071. RP CHANH, TC (reprint author), SW FDN BIOMED RES,DEPT VIROL & IMMUNOL,POB 28147,SAN ANTONIO,TX 78228, USA. NR 43 TC 6 Z9 6 U1 0 U2 0 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA LINACRE HOUSE JORDAN HILL, OXFORD, OXON, ENGLAND OX2 8DP SN 0264-410X J9 VACCINE JI Vaccine PD APR PY 1995 VL 13 IS 5 BP 479 EP 485 DI 10.1016/0264-410X(94)00020-N PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA QR844 UT WOS:A1995QR84400009 PM 7639015 ER PT J AU KOTLOFF, KL LOSONSKY, GA NATARO, JP WASSERMAN, SS HALE, TL TAYLOR, DN NEWLAND, JW SADOFF, JC FORMAL, SB LEVINE, MM AF KOTLOFF, KL LOSONSKY, GA NATARO, JP WASSERMAN, SS HALE, TL TAYLOR, DN NEWLAND, JW SADOFF, JC FORMAL, SB LEVINE, MM TI EVALUATION OF THE SAFETY, IMMUNOGENICITY, AND EFFICACY IN HEALTHY-ADULTS OF 4 DOSES OF LIVE ORAL HYBRID ESCHERICHIA-COLI SHIGELLA-FLEXNERI 2A VACCINE STRAIN ECSF2A-2 SO VACCINE LA English DT Article DE PHASE I STUDY; MUCOSAL IMMUNITY; SHIGELLA FLEXNERI ID SALMONELLA-TYPHI; BIVALENT VACCINE; IMMUNOGLOBULIN-A; SOMATIC ANTIGEN; SECRETING CELLS; SONNEI VACCINE; HUMANS; PROTECTION; MONKEYS; PLASMID AB In previous trials, live invasive Escherichia coli-Shigella flexneri 2a hybrid vaccine candidate EcSf2a-2, administered to adult volunteers as 3 doses of ca. 2x10(9) colony, forming units (c.f.u.) spaced over one week, induced fever and/or diarrhea in 11% of subjects and provided only limited protection (36% efficacy) against illness following challenge with virulent S. flexneri 2a. We sought to improve the clinical safety of this vaccine by administering a lower inoculum, and to enhance protective immunity by administering additional booster closes at 2 weeks. Twenty-one healthy adults were immunized with ca. 7x10(8) c.f.u. of EcSf2a-2 on days 0, 3, 14, and 17. The vaccine consistently colonized the intestine without causing serious adverse reactions; mild diarrhea developed in one subject and low grade fever in another. Vaccination elicited an antibody secreting cell (ASC) response to lipopolysaccharide (LPS) in all subjects, which was highest on day 7 and notably diminished thereafter on days 10, 16, 21, and 24, suggesting that active mucosal immunity developed rapidly,. The magnitude of the response was was modest (geometric mean peak = 16 IgA ASC/10(6) peripheral blood mononuclear cells) and an IgG serological response to LPS was detected in only 19% of subjects. Following experimental challenge with virulent S. flexneri 2a administered with bicarbonate buffer, shigellosis (diarrhea, dysentery, or fever) developed in 10 of 16 vaccine recipients (63%) and in 12 of 14 unvaccinated controls (86%), resulting in a vaccine efficacy of 27% (95% confidence limits -197, 82, p = 0.15, 1-tailed). We conclude that four doses of EcSf2a-2 spaced over 17 days at inocula that are well-tolerated do not confer significant protection against illness following experimental challenge of healthy adult volunteers. C1 UNIV MARYLAND,SCH MED,DEPT PEDIAT,DIV INFECT DIS & TROP PEDIAT,BALTIMORE,MD 21201. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. RP KOTLOFF, KL (reprint author), UNIV MARYLAND,SCH MED,CTR VACCINE DEV,DEPT MED,DIV GEOG MED,10 S PINE ST,BALTIMORE,MD 21201, USA. RI kotloff, karen/E-7768-2012 OI kotloff, karen/0000-0003-1808-6431 NR 38 TC 55 Z9 58 U1 0 U2 1 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA LINACRE HOUSE JORDAN HILL, OXFORD, OXON, ENGLAND OX2 8DP SN 0264-410X J9 VACCINE JI Vaccine PD APR PY 1995 VL 13 IS 5 BP 495 EP 502 DI 10.1016/0264-410X(94)00011-B PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA QR844 UT WOS:A1995QR84400011 PM 7639017 ER PT J AU DEHAVENHUDKINS, DL ALLEN, JT HUDKINS, RL STUBBINS, JF TORTELLA, FC AF DEHAVENHUDKINS, DL ALLEN, JT HUDKINS, RL STUBBINS, JF TORTELLA, FC TI ANTICONVULSANT ACTIVITY OF CARAMIPHEN ANALOGS SO LIFE SCIENCES LA English DT Article DE ANTICONVULSANT; CARAMIPHEN; [H-3] 1,2-DI(2-TOLYL)GUANIDINE; SEIZURE; [H-3] (+)PENTAZOCINE ID NONOPIOID ANTITUSSIVES; BINDING; SOMAN; DEXTROMETHORPHAN; AGENTS; ANTAGONISTS; DERIVATIVES; AFFINITY; LIGANDS; POTENT AB Caramiphen potently blocks maximal electroshock (MES)-induced seizures in mice and rats. The anticonvulsant mechanism has been hypothesized to be due to high-affinity binding to sigma recognition sites in brain. To study the structure-activity relationship for anticonvulsant activity of caramiphen we evaluated 8 analogs in MES-induced seizures in rats and also determined whether a correlation exists between anticonvulsant potency and a binding affinity. Some of the analogs potently inhibited sigma binding but were devoid of anticonvulsant activity. Aminocaramiphen 2 (ED(50) = 3.4 mg/kg) and N-methyl-4-piperidinyl 1-phenylcyclopentanecarboxylate 9 (ED(50) = 4.8 mg/kg) showed anticonvulsant activity comparable to caramiphen (ED(50) = 3.1 mg/kg), although in sigma binding assays the affinities were 3-and 30-fold less than caramiphen, respectively. In the presence of 250 mu M of phenytoin, caramiphen and p-aminocaramiphen showed 3- to 5-fold increases in affinity for [H-3](+)pentazocine binding, whereas p-iodocaramiphen, which was inactive as an anticonvulsant, showed no change in affinity for sigma binding. These results indicate that anticonvulsant activity of the caramiphen analogs is not due to interaction with sigma binding sites. C1 STERLING WINTHROP PHARMACEUT RES DIV,DEPT BIOCHEM,COLLEGEVILLE,PA 19426. VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT MED CHEM,RICHMOND,VA 23298. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT MED NEUROSCI,WASHINGTON,DC 20307. NR 26 TC 7 Z9 7 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0024-3205 J9 LIFE SCI JI Life Sci. PD MAR 31 PY 1995 VL 56 IS 19 BP 1571 EP 1576 DI 10.1016/0024-3205(95)00123-N PG 6 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA QQ788 UT WOS:A1995QQ78800004 PM 7723585 ER PT J AU WU, YW CHANG, SC AF WU, YW CHANG, SC TI CODING SCHEME FOR MULTIPLE-ACCESS ADDER CHANNEL WITH AND WITHOUT IDLE USERS SO ELECTRONICS LETTERS LA English DT Article DE MULTIACCESS SYSTEMS; CODES AB A new coding scheme with asymptotically good, uniquely decodable codes for the multiple-access adder channel with and without idle users is developed based on the Lindstrom combinatory detection algorithm. C1 GEORGE MASON UNIV,DEPT ELECT & COMP ENGN,FAIRFAX,VA 22030. RP WU, YW (reprint author), USA,CECOM RDEC,,INTELLIGENCE & ELECTR WARFARE DIRECTORATE,AMSEL RD IEW TRS,VINT HILL FARMS STN,WARRENTON,VA 22186, USA. NR 4 TC 5 Z9 5 U1 0 U2 1 PU IEE-INST ELEC ENG PI HERTS PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTS, ENGLAND SG1 2AY SN 0013-5194 J9 ELECTRON LETT JI Electron. Lett. PD MAR 30 PY 1995 VL 31 IS 7 BP 523 EP 524 DI 10.1049/el:19950380 PG 2 WC Engineering, Electrical & Electronic SC Engineering GA QT823 UT WOS:A1995QT82300011 ER PT J AU MCLANE, GF CASAS, L REID, JS NICOLET, MA AF MCLANE, GF CASAS, L REID, JS NICOLET, MA TI REACTIVE ION ETCHING OF TA-SI-N DIFFUSION-BARRIERS IN CHF3+O-2 SO ELECTRONICS LETTERS LA English DT Article DE REACTIVE ION ETCHING ID SILICON-NITRIDE; TANTALUM; METALLIZATIONS; CF4 AB Reactive ion etching of Ta36Si14N50 diffusion barrier layers was performed in CHF3+O-2 plasmas. Etch depths and rates were determined as a function of etch gas composition, cathode power, and etching time. Etching proceeds only after an initial delay which depends on gas composition and cathode power. This delay is attributed to the presence of a native surface oxide which must first be removed before etching can commence. Maximum etch rate was attained at 62.5% O-2 concentration, which also corresponds to minimum delay. C1 CALTECH,PASADENA,CA 91125. RP MCLANE, GF (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 9 TC 2 Z9 2 U1 0 U2 1 PU IEE-INST ELEC ENG PI HERTS PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTS, ENGLAND SG1 2AY SN 0013-5194 J9 ELECTRON LETT JI Electron. Lett. PD MAR 30 PY 1995 VL 31 IS 7 BP 591 EP 592 DI 10.1049/el:19950363 PG 2 WC Engineering, Electrical & Electronic SC Engineering GA QT823 UT WOS:A1995QT82300057 ER PT J AU SHARMA, A SUNDARAM, ST ZHANG, YZ BRODMAN, BW AF SHARMA, A SUNDARAM, ST ZHANG, YZ BRODMAN, BW TI BIODEGRADATION OF NITRATE ESTERS .2. DEGRADATION OF NITROCELLULOSE BY A FUNGUS ISOLATED FROM A DOUBLE-BASE PROPELLANT SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article ID PHANEROCHAETE-CHRYSOSPORIUM; NITRITE REDUCTASE; HYDROGEN-PEROXIDE; GLUCOSE-OXIDASE; PURIFICATION; DENITRIFICATION; POLLUTANTS; PHOTOLYSIS; RADICALS AB An organism found to be growing on moist double-base propellant, containing nitrocellulose (NC) and nitroglycerine aerobically degraded NC in submerged cultivation. This organism, which was subsequently identified as Penicillium corylophilum Dierckx, was able to degrade the NC (13.17% N) when it was present as the sole nitrogen source, in conjunction with either starch or xylan as a carbon source. It was found that 20% of the NC was utilized in a 3-day period. Also, NC degradation was studied utilizing Fusarium solani IFO 310393, a denitrifying fungus, in combination with P. corylophilum; however, no increased utilization was observed. Evidence for the degradation includes a decrease in the NC weight, an increase in the biomass weight, the presence of cellulolytic and denitrifying enzymes, and other appropriate growth parameters. (C) 1995 John Wiley and Sons, Inc. C1 USA,CTR ARMAMENTS RES DEV & ENGN,PICATINNY ARSENAL,NJ 07806. GEOCENTERS INC,LAKE HOPATCONG,NJ 07849. NR 41 TC 10 Z9 11 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0021-8995 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD MAR 28 PY 1995 VL 55 IS 13 BP 1847 EP 1854 DI 10.1002/app.1995.070551315 PG 8 WC Polymer Science SC Polymer Science GA QJ628 UT WOS:A1995QJ62800015 ER PT J AU DAVE, PR AXENROD, T QI, LD BRACUTI, A AF DAVE, PR AXENROD, T QI, LD BRACUTI, A TI SYNTHESIS OF 1,2,2-TRINITROADAMANTANE SO JOURNAL OF ORGANIC CHEMISTRY LA English DT Note ID ALPHA-NITRO KETONES; NITROKETONES C1 CUNY CITY COLL,DEPT CHEM,NEW YORK,NY 10031. USA,ARMAMENTS RES,CTR DEV & ENGN,PICATINNY ARSENAL,NJ 07806. RP DAVE, PR (reprint author), ARDEC,GEOCENTERS INC,762 ROUTE 15 S,LAKE HOPATCONG,NJ 07849, USA. NR 24 TC 8 Z9 9 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0022-3263 J9 J ORG CHEM JI J. Org. Chem. PD MAR 24 PY 1995 VL 60 IS 6 BP 1895 EP 1896 DI 10.1021/jo00111a062 PG 2 WC Chemistry, Organic SC Chemistry GA QN888 UT WOS:A1995QN88800062 ER PT J AU SUN, JY HUANG, Q GILBERT, JA AF SUN, JY HUANG, Q GILBERT, JA TI COMPARING CROSS-TALK IN DOPED SCINTILLATING-FIBER BUNDLES SO APPLIED OPTICS LA English DT Note ID STOKES AB A simple experimental technique to measure and compare cross talk in fiber bundles designed for high-energy-particle-tracking systems in colliders is described. Each bundle is composed of individual step-index, multimode fibers that are doped with a scintillating material at a given concentration. Results for two different scintillators doped at two different concentrations are included to demonstrate the validity and the potential of the technique. C1 USA,MISSILE COMMAND,WEAPONS SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898. UNIV ALABAMA,DEPT MECH & AEROSP ENGN,HUNTSVILLE,AL 35899. RP SUN, JY (reprint author), UNIV ALABAMA,DEPT PHYS,HUNTSVILLE,AL 35899, USA. NR 5 TC 3 Z9 3 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD MAR 20 PY 1995 VL 34 IS 9 BP 1536 EP 1539 PG 4 WC Optics SC Optics GA QM282 UT WOS:A1995QM28200011 PM 21037693 ER PT J AU BEAVEN, SG LOCKHART, GL GOGINENI, SP HOSSEINMOSTAFA, AR JAZEK, K GOW, AJ PEROVICH, DK FUNG, AK TJUATJA, S AF BEAVEN, SG LOCKHART, GL GOGINENI, SP HOSSEINMOSTAFA, AR JAZEK, K GOW, AJ PEROVICH, DK FUNG, AK TJUATJA, S TI LABORATORY MEASUREMENTS OF RADAR BACKSCATTER FROM BARE AND SNOW-COVERED SALINE ICE SHEETS SO INTERNATIONAL JOURNAL OF REMOTE SENSING LA English DT Article ID SEA ICE; SURFACE; SCATTERING AB We performed experiments to collect radar backscatter data at K-u (13.4 GHz) and C bands (5.3 GHz) over simulated sea ice at the U.S. Army Cold Regions Research and Engineering Laboratory (CRREL) during the 1990 and 1992 winter seasons. These experiments were conducted over bare saline ice grown in an indoor tank and an outdoor pond facility. The radar data were calibrated using a complex vector calibration scheme to reduce systematic effects. In conjunction with the radar measurements we measured ice physical properties. These measurements demonstrate that the dominant backscatter mechanism for bare saline ice is surface scattering. Both the copolarized and cross-polarized measurements compare favourably with the predictions of surface scattering models at two frequencies. During the 1992 indoor tank experiment we applied four successive layers of snow (about 2.5 cm each) to the saline ice sheet after the ice thickness had reached about 12 cm. The backscatter at normal incidence dropped by 15 dB and the backscatter at 45 degrees increased by 11 dB with the introduction of the first snow layer. The application of three more layers, each of approximately 2.5 cm depth, did not alter the radar signature significantly. By modelling and direct observation we found that the initial change in the signature was caused by a roughening of the surface at the snow-ice interface and the change in dielectric contrast at the snow-ice interface. C1 OHIO STATE UNIV,BYRD POLAR RES CTR,COLUMBUS,OH 43210. USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. UNIV TEXAS,DEPT ELECT ENGN,WAVE SCATTERING RES CTR,ARLINGTON,TX 76019. RP BEAVEN, SG (reprint author), UNIV KANSAS,DEPT ELECT ENGN & COMP SCI,RADAR SYST & REMOTE SENSING LAB,2291 IRVING HILL RD,LAWRENCE,KS 66045, USA. NR 25 TC 36 Z9 37 U1 0 U2 2 PU TAYLOR & FRANCIS LTD LONDON PI LONDON PA ONE GUNDPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 0143-1161 J9 INT J REMOTE SENS JI Int. J. Remote Sens. PD MAR 20 PY 1995 VL 16 IS 5 BP 851 EP 876 PG 26 WC Remote Sensing; Imaging Science & Photographic Technology SC Remote Sensing; Imaging Science & Photographic Technology GA QR620 UT WOS:A1995QR62000007 ER PT J AU HOGE, CW SHLIM, DR GHIMIRE, M RABOLD, JG PANDEY, P WALCH, A RAJAH, R GAUDIO, P ECHEVERRIA, P AF HOGE, CW SHLIM, DR GHIMIRE, M RABOLD, JG PANDEY, P WALCH, A RAJAH, R GAUDIO, P ECHEVERRIA, P TI PLACEBO-CONTROLLED TRIAL OF COTRIMOXAZOLE FOR CYCLOSPORA INFECTIONS AMONG TRAVELERS AND FOREIGN RESIDENTS IN NEPAL SO LANCET LA English DT Article ID ACQUIRED-IMMUNODEFICIENCY-SYNDROME; ISOSPORA-BELLI INFECTION; CYANOBACTERIUM-LIKE BODIES; DIARRHEA; TRAVELERS; ORGANISM; PATHOGEN AB Cyclospora is a coccidian (previously referred to as cyanobacterium-like bodies) that has been implicated in cases of prolonged diarrhoea. The average duration of symptoms is more than three weeks, and no specific treatment has been shown to shorten the illness. A case report suggested that co-trimoxazole may be effective. Expatriate persons with gastrointestinal complaints and cyclospora detected on examination of faeces were recruited from two clinics in Kathmandu, Nepal, between May and August, 1994. Participants were assigned in a randomised, double-blinded manner to receive either co-trimoxazole (160 mg trimethoprim, 800 mg sulphamethoxazole) or placebo tablets twice daily for 7 days. Of 40 patients included in the study, 21 received co-trimoxazole and 19 placebo. There were no significant differences between these two groups in age, sex, time in Nepal, duration or severity of illness, or presence of other enteric pathogens. After 3 days, 71% of patients receiving co-trimoxazole still had cyclospora detected, compared with 100% of patients receiving placebo (p=0.016). After 7 days, cyclospora was detected in 1 (6%) of 16 patients treated with co-trimoxazole who submitted stool specimens compared with 15 (88%) of 17 patients receiving placebo (p<0.0001). Eradication of the organism was correlated with clinical improvement. There was no evidence of relapse of infection among treated patients followed for an additional 7 days. Treatment with co-trimoxazole for 7 days was effective in curing cyclospora infection among an expatriate population in Nepal. C1 CIWEC CLIN,KATMANDU,NEPAL. US EMBASSY & PEACE CORPS MED UNIT,KATMANDU,NEPAL. RP HOGE, CW (reprint author), ARMED FORCES RES INST MED SCI,USA MED COMPONENT,DEPT BACTERIOL IMMUNOL & MOLEC GENET,BANGKOK 10400,THAILAND. NR 18 TC 113 Z9 119 U1 0 U2 0 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0099-5355 J9 LANCET JI Lancet PD MAR 18 PY 1995 VL 345 IS 8951 BP 691 EP 693 DI 10.1016/S0140-6736(95)90868-4 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA QM732 UT WOS:A1995QM73200009 PM 7885125 ER PT J AU ASHANI, Y RADIC, Z TSIGELNY, I VELLOM, DC PICKERING, NA QUINN, DM DOCTOR, BP TAYLOR, P AF ASHANI, Y RADIC, Z TSIGELNY, I VELLOM, DC PICKERING, NA QUINN, DM DOCTOR, BP TAYLOR, P TI AMINO-ACID-RESIDUES CONTROLLING REACTIVATION OF ORGANOPHOSPHONYL CONJUGATES OF ACETYLCHOLINESTERASE BY MONOQUATERNARY AND BISQUATERNARY OXIMES SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID STEREOSPECIFIC REACTIVATION; SOMAN; INVITRO; BUTYRYLCHOLINESTERASE; SPECIFICITY; TORPEDO; BINDING; BRAIN; SITE; EEL AB Single and multiple site mutants of recombinant mouse acetylcholinesterase (rMoAChE) were inhibited with racemic 7-(methylethoxyphosphinyloxy)-1-methylquinolinium iodide (MEPQ) and the resulting mixture of two enantiomers, CH3PR,S(O)(OC2H5)-AChE(EMP(R,S)-AChE), were subjected to reactivation with 2-(hydroxyiminomethyl)-1-methylpyridinium methanesulfonate (P2S) and 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride (HI-6), Kinetic analysis of the reactivation profiles revealed biphasic behavior with an approximate 1:1 ratio of two presumed reactivatable enantiomeric components. Equilibrium dissociation and kinetic rate constants for reactivation of site-specific mutant enzymes were compared with those obtained for wild-type rMoAChE, tissue-derived Torpedo AChE and human plasma butyrylcholinesterase. Substitution of key amino acid residues at the entrance to the active-site gorge (Trp-286, Tyr-124, Tyr-72, and Asp-74) had a greater influence on the reactivation kinetics of the bisquaternary reactivator HI-6 compared with the monoquaternary reactivator P2S, Replacement of Phe-295 by Leu enhanced reactivation by HI-6 but not by P2S, Of residues forming the choline-binding subsite, the E202Q mutation had a dominant influence where reactivation by both oximes was decreased 16- to 33-fold, Residues Trp-86 and Tyr-337 in this subsite showed little involvement, These kinetic findings, together with energy minimization of the oxime complex with the phosphonylated enzyme, provide a model for differences in the reactivation potencies of P2S and HI-6, The two kinetic components of oxime reactivation of MEPQ-inhibited AChEs arise from the chirality of O-ethyl methylphosphonyl moieties conjugated with Ser-203 and may be attributable to the relative stability of the phosphonyl oxygen of the two enantiomers in the oxyanion hole, C1 WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC 20307. UNIV CALIF SAN DIEGO,DEPT PHARMACOL,LA JOLLA,CA 92093. NR 39 TC 78 Z9 80 U1 0 U2 4 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD MAR 17 PY 1995 VL 270 IS 11 BP 6370 EP 6380 PG 11 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA QM945 UT WOS:A1995QM94500097 PM 7890775 ER PT J AU PEARTON, SJ ABERNATHY, CR WILSON, RG REN, F ZAVADA, JM AF PEARTON, SJ ABERNATHY, CR WILSON, RG REN, F ZAVADA, JM TI EFFECT OF ION ENERGY ON HYDROGEN DIFFUSION IN N- AND P- GAAS SO ELECTRONICS LETTERS LA English DT Article DE SEMICONDUCTOR DOPING; PASSIVATION AB The ion energy during electron cyclotron resonance (ECR) plasma hydrogenation is found to have a strong effect on both the effective diffusivity and solubility of hydrogen in n(+) and p(+) GaAs. For fixed plasma exposure conditions (30 min, 250 degrees C) the diffusion depths for -150 V acceleration voltage are similar to 50 and similar to 100% larger, respectively, in p(+)- and n(+)-GaAs compared to 0V acceleration voltage. The smaller incorporation depths at lower ion energy coincide with much larger peak hydrogen concentrations and higher apparent thermal stability of passivated dopants. C1 HUGHES RES LABS,MALIBU,CA 90265. AT&T BELL LABS,MURRAY HILL,NJ 07974. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP PEARTON, SJ (reprint author), UNIV FLORIDA,GAINESVILLE,FL 32611, USA. RI Schaff, William/B-5839-2009 NR 4 TC 6 Z9 6 U1 0 U2 1 PU IEE-INST ELEC ENG PI HERTS PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTS, ENGLAND SG1 2AY SN 0013-5194 J9 ELECTRON LETT JI Electron. Lett. PD MAR 16 PY 1995 VL 31 IS 6 BP 496 EP 497 DI 10.1049/el:19950326 PG 2 WC Engineering, Electrical & Electronic SC Engineering GA QQ517 UT WOS:A1995QQ51700057 ER PT J AU CHAN, DS AF CHAN, DS TI RECOMMENDED DAILY ALLOWANCE OF MAINTENANCE PARENTERAL-NUTRITION IN INFANTS AND CHILDREN SO AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY LA English DT Letter RP CHAN, DS (reprint author), TRIPLER ARMY MED CTR,MCHK-PY,DEPT ARMY PHARM SERV,HONOLULU,HI 96859, USA. NR 18 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 SN 1079-2082 J9 AM J HEALTH-SYST PH JI Am. J. Health-Syst. Pharm. PD MAR 15 PY 1995 VL 52 IS 6 BP 651 EP 653 PG 3 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA QM521 UT WOS:A1995QM52100014 PM 7606583 ER PT J AU AHUMADA, AJ ROHALY, AM WATSON, AB AF AHUMADA, AJ ROHALY, AM WATSON, AB TI IMAGE DISCRIMINATION MODELS PREDICT OBJECT DETECTION IN NATURAL BACKGROUNDS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NASA,AMES RES CTR,MOFFETT FIELD,CA 94035. USA,RES LAB,ABERDEEN PROVING GROUND,MD 21010. NR 2 TC 4 Z9 4 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1995 VL 36 IS 4 BP S439 EP S439 PG 1 WC Ophthalmology SC Ophthalmology GA QM915 UT WOS:A1995QM91502008 ER PT J AU ALFARO, DV NOSSOV, P SCHECH, J WINTER, L BRIGGS, J MOSS, S AF ALFARO, DV NOSSOV, P SCHECH, J WINTER, L BRIGGS, J MOSS, S TI INTRAVENOUS CEFAZOLIN IN PENETRATING EYE TRAUMA - A SWINE MODEL SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1995 VL 36 IS 4 BP S614 EP S614 PG 1 WC Ophthalmology SC Ophthalmology GA QM915 UT WOS:A1995QM91502828 ER PT J AU BELYEA, DA GEIGER, JM CHALFA, R AF BELYEA, DA GEIGER, JM CHALFA, R TI THE EFFECT OF CRICOID PRESSURE ON INTRAOCULAR-PRESSURE IN SUPINE AWAKE VOLUNTEERS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1995 VL 36 IS 4 BP S81 EP S81 PG 1 WC Ophthalmology SC Ophthalmology GA QM915 UT WOS:A1995QM91500394 ER PT J AU BLANTON, CL SCHALLHOM, SC NG, JD GILBERT, BT WHITE, LJ PARMLEY, VC MADER, TH AF BLANTON, CL SCHALLHOM, SC NG, JD GILBERT, BT WHITE, LJ PARMLEY, VC MADER, TH TI REFRACTIVE CHANGES DURING PROLONGED EXPOSURE TO ALTITUDE FOLLOWING REFRACTIVE SURGERY SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USN,MED CTR,DEPT OPHTHALMOL,SAN DIEGO,CA 92132. EISENHOWER ARMY MED CTR,DEPT OPHTHALMOL,FT GORDON,GA. MADIGAN ARMY MED CTR,DEPT OPHTHALMOL,TACOMA,WA 98431. CASCADE EYE & SKIN CTR,TACOMA,WA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1995 VL 36 IS 4 BP S435 EP S435 PG 1 WC Ophthalmology SC Ophthalmology GA QM915 UT WOS:A1995QM91501990 ER PT J AU BRIGGS, J NOSSOV, P SCHECH, J SANFORD, EG MICHAUS, M DALGETTY, M ALFARO, DV AF BRIGGS, J NOSSOV, P SCHECH, J SANFORD, EG MICHAUS, M DALGETTY, M ALFARO, DV TI INTRAVENOUS GENTAMICIN AND CEFTAZIDIME IN PENETRATING EYE TRAUMA - A SWINE MODEL SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1995 VL 36 IS 4 BP S613 EP S613 PG 1 WC Ophthalmology SC Ophthalmology GA QM915 UT WOS:A1995QM91502827 ER PT J AU CHAO, GM ODOM, JV SCHWARTZ, T AF CHAO, GM ODOM, JV SCHWARTZ, T TI SUBTHRESHOLD BINOCULAR INTERACTION - A COMPARISON OF BINOCULAR NORMALS TO A BINOCULAR ABNORMAL WITH MONOFIXATION SYNDROME SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,RES LAB,WASHINGTON,DC 20310. W VIRGINIA UNIV,MED CTR,SCH MED,DEPT OPHTHALMOL,MORGANTOWN,WV 26506. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1995 VL 36 IS 4 BP S46 EP S46 PG 1 WC Ophthalmology SC Ophthalmology GA QM915 UT WOS:A1995QM91500219 ER PT J AU FREUND, DE MCCALLY, RL FARRELL, RA SLINEY, DH AF FREUND, DE MCCALLY, RL FARRELL, RA SLINEY, DH TI THEORETICAL INVESTIGATIONS OF RETINAL TEMPERATURE-CHANGES RESULTING FROM LASER-DIODE EXPOSURE SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,CTR HLTH PROMOT & PREVENT MED,ABERDEEN PROVING GROUND,MD 21010. JOHNS HOPKINS UNIV,APPL PHYS LAB,LAUREL,MD 20723. NR 0 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1995 VL 36 IS 4 BP S117 EP S117 PG 1 WC Ophthalmology SC Ophthalmology GA QM915 UT WOS:A1995QM91500572 ER PT J AU GAGLIANO, DA DICARLO, CD BOPPART, SA COX, AB HAMMER, DX FUJIMOTO, JG HEE, MR SWANSON, EA ROACH, WP STUCK, BE AF GAGLIANO, DA DICARLO, CD BOPPART, SA COX, AB HAMMER, DX FUJIMOTO, JG HEE, MR SWANSON, EA ROACH, WP STUCK, BE TI OPTICAL COHERENCE TOMOGRAPHY (OCT) EVALUATION OF LENTICULAR OPACIFICATION IN NONHUMAN-PRIMATES SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,MED RES DETACHMENT,BROOKS AFB,TX. USAF,ARMSTRONG LAB,OCCUPAT & ENVIRONM HLTH DIRECTORATE,BROOKS AFB,TX 78235. MIT,DEPT ELECT ENGN,CAMBRIDGE,MA 02139. RI Boppart, Stephen/C-7338-2009 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1995 VL 36 IS 4 BP S799 EP S799 PG 1 WC Ophthalmology SC Ophthalmology GA QM915 UT WOS:A1995QM91503689 ER PT J AU GILBERT, BN GEORGE, DP PARMLEY, VC RIFFLE, JE RIBER, JI AF GILBERT, BN GEORGE, DP PARMLEY, VC RIFFLE, JE RIBER, JI TI ANALYSIS OF METALLIC DEBRIS FOLLOWING PHACOEMULSIFICATION SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 MADIGAN ARMY MED CTR,DEPT OPHTHALMOL,TACOMA,WA 98431. KELLER ARMY COMMUNITY HOSP,DEPT OPHTHALMOL,W POINT,NY. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1995 VL 36 IS 4 BP S809 EP S809 PG 1 WC Ophthalmology SC Ophthalmology GA QM915 UT WOS:A1995QM91503744 ER PT J AU KLYMENKO, V VERONAS, RW MARTIN, JS BEASLEY, HH MCLEAN, WE AF KLYMENKO, V VERONAS, RW MARTIN, JS BEASLEY, HH MCLEAN, WE TI THE PERCEPTION OF LUNING IN MONOCULAR REGIONS OF PARTIAL BINOCULAR OVERLAP HELMET-MOUNTED DISPLAYS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 UES INC,FT RUCKER,AL. USA,AEROMED RES LAB,FT RUCKER,AL 36360. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1995 VL 36 IS 4 BP S668 EP S668 PG 1 WC Ophthalmology SC Ophthalmology GA QM915 UT WOS:A1995QM91503052 ER PT J AU KMENTA, S POLEWARCZYK, J CUSUMANO, E HECKMANN, T WITUS, G MEITZLER, T AF KMENTA, S POLEWARCZYK, J CUSUMANO, E HECKMANN, T WITUS, G MEITZLER, T TI VISUAL-SEARCH OF DRIVERS AT INTERSECTIONS - A FIELD-STUDY SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 OPTIMETR INC,ANN ARBOR,MI. USA,CTR TANK AUTOMOT RES DEV & ENGN,WARREN,MI. STANFORD UNIV,STANFORD,CA 94305. GM CORP,CTR SAFETY,WARREN,MI 48090. GM CORP,CTR RES & DEV,WARREN,MI 48090. RI Meitzler, Thomas/D-1065-2017 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1995 VL 36 IS 4 BP S899 EP S899 PG 1 WC Ophthalmology SC Ophthalmology GA QM915 UT WOS:A1995QM91504118 ER PT J AU LUND, DJ ZWICK, H SCHUSCHEREBA, ST ELLIOT, R AF LUND, DJ ZWICK, H SCHUSCHEREBA, ST ELLIOT, R TI THE UTILIZATION OF SMALL EYES IN THE ANALYSIS OF LASER RETINAL DAMAGE SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,SAN ANTONIO,TX 78235. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1995 VL 36 IS 4 BP S118 EP S118 PG 1 WC Ophthalmology SC Ophthalmology GA QM915 UT WOS:A1995QM91500576 ER PT J AU MORSE, SE KOTULAK, JC BILLOCK, VA AF MORSE, SE KOTULAK, JC BILLOCK, VA TI RED-GREEN OPPONENT-COLOR CHANNEL AND ACCOMMODATION SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,AEROMED RES LAB,FT RUCKER,AL 36360. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1995 VL 36 IS 4 BP S13 EP S13 PG 1 WC Ophthalmology SC Ophthalmology GA QM915 UT WOS:A1995QM91500052 ER PT J AU NOSSOV, PC BRIETZKE, S LIGGETT, PE ALFARO, DV AF NOSSOV, PC BRIETZKE, S LIGGETT, PE ALFARO, DV TI SCANNING ELECTRON-MICROSCOPY OF FOSCARNET TOXICITY TO THE PRIMATE RETINA SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. YALE UNIV,CTR EYE,NEW HAVEN,CT 06520. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1995 VL 36 IS 4 BP S778 EP S778 PG 1 WC Ophthalmology SC Ophthalmology GA QM915 UT WOS:A1995QM91503590 ER PT J AU RABIN, J WICKS, J AF RABIN, J WICKS, J TI THE SMALL LETTER CONTRAST TEST - SENSITIVITY, RELIABILITY AND APPLICATION SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,AEROMED RES LAB,FT RUCKER,AL 36362. NR 1 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1995 VL 36 IS 4 BP S943 EP S943 PG 1 WC Ophthalmology SC Ophthalmology GA QM915 UT WOS:A1995QM91504336 ER PT J AU SCHUSCHEREBA, ST BOWMAN, PD UJIMON, V HOXIE, S CROSS, ME LUND, DJ AF SCHUSCHEREBA, ST BOWMAN, PD UJIMON, V HOXIE, S CROSS, ME LUND, DJ TI CYTOKINE MESSENGER-RNA SYNTHESIS IN MOUSE RETINA AFTER LASER INJURY BY REVERSE-TRANSCRIPTASE POLYMERASE CHAIN-REACTION (RT-PCR) SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,USA MED RES DETACHMENT,BROOKS AFB,TX 78235. USA,INST SURG RES,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1995 VL 36 IS 4 BP S256 EP S256 PG 1 WC Ophthalmology SC Ophthalmology GA QM915 UT WOS:A1995QM91501159 ER PT J AU STUCK, BE ZWICK, H MOLCHANY, JW GAGLIANO, DA BELKIN, M AF STUCK, BE ZWICK, H MOLCHANY, JW GAGLIANO, DA BELKIN, M TI ACCIDENTAL HUMAN LASER RETINAL INJURIES FROM A HAND-HELD MILITARY LASER RANGEFINDER SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,SAN ANTONIO,TX. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1995 VL 36 IS 4 BP S118 EP S118 PG 1 WC Ophthalmology SC Ophthalmology GA QM915 UT WOS:A1995QM91500575 ER PT J AU THAYER, J BRUNETTE, I AMYOT, M DESJARDINS, D BOISJOLY, H SHI, ZH MICHALUK, D BERNIER, P AF THAYER, J BRUNETTE, I AMYOT, M DESJARDINS, D BOISJOLY, H SHI, ZH MICHALUK, D BERNIER, P TI CORNEAL ENDOTHELIAL-CELL LOSS AFTER PHACOEMULSIFICATION, TRABECULECTOMY AND COMBINED PHACOEMULSIFICATION AND TRABECULECTOMY SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. HOSP MAISSONNEUVE ROSEMONT,DEPT OPHTHALMOL,MONTREAL,PQ,CANADA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1995 VL 36 IS 4 BP S36 EP S36 PG 1 WC Ophthalmology SC Ophthalmology GA QM915 UT WOS:A1995QM91500164 ER PT J AU UYEMURA, MJ UYEMURA, MD FRYE, MB PEELE, KA AF UYEMURA, MJ UYEMURA, MD FRYE, MB PEELE, KA TI DURATION OF SIMULATED RELATIVE AFFERENT PUPILLARY DEFECTS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 FITZSIMONS ARMY MED CTR,AURORA,CO 80045. UNIV MIAMI,SCH MED,MIAMI,FL 33152. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1995 VL 36 IS 4 BP S456 EP S456 PG 1 WC Ophthalmology SC Ophthalmology GA QM915 UT WOS:A1995QM91502092 ER PT J AU WITUS, G HECKMANN, T MEITZLER, T GERHART, G SOHN, EJ AF WITUS, G HECKMANN, T MEITZLER, T GERHART, G SOHN, EJ TI EVALUATING A COMPUTER-MODEL OF SEARCH AND DETECTION IN COMPLEX SCENES SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 OPTIMETR INC,ANN ARBOR,MI. USA,TANK AUTOMOT RES & DEV CTR,WARREN,MI. GM CORP,CTR RES & DEV,WARREN,MI 48090. RI Meitzler, Thomas/D-1065-2017 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1995 VL 36 IS 4 BP S900 EP S900 PG 1 WC Ophthalmology SC Ophthalmology GA QM915 UT WOS:A1995QM91504119 ER PT J AU ZWICK, H GAGLIANO, DA ZUCLICH, JA STUCK, BE GLICKMAN, R BELKIN, M AF ZWICK, H GAGLIANO, DA ZUCLICH, JA STUCK, BE GLICKMAN, R BELKIN, M TI SECONDARY EFFECTS OF ACUTE LASER RETINAL INJURY SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 UNIV TEXAS,HLTH SCI CTR,USA,SAN ANTONIO,TX 78284. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1995 VL 36 IS 4 BP S118 EP S118 PG 1 WC Ophthalmology SC Ophthalmology GA QM915 UT WOS:A1995QM91500574 ER PT J AU ZAVADA, JM CASEY, HC STATES, RJ NOVAK, SW LONI, A AF ZAVADA, JM CASEY, HC STATES, RJ NOVAK, SW LONI, A TI CORRELATION OF SUBSTITUTIONAL HYDROGEN TO REFRACTIVE-INDEX PROFILES IN ANNEALED PROTON-EXCHANGED Z-CUT AND X-CUT LINBO3 SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID WAVE-GUIDES; WAVEGUIDES C1 DUKE UNIV,DEPT ELECT ENGN,DURHAM,NC 27708. EVANS E INC,PLAINSBORO,NJ 08536. DEF RES AGCY,MALVERN WR14 3PS,WORCS,ENGLAND. RP ZAVADA, JM (reprint author), USA,RES OFF,RES TRIANGLE PK,NC 27709, USA. NR 24 TC 24 Z9 25 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAR 15 PY 1995 VL 77 IS 6 BP 2697 EP 2708 DI 10.1063/1.358738 PG 12 WC Physics, Applied SC Physics GA QN148 UT WOS:A1995QN14800072 ER PT J AU ANDREAS, EL CLAFFEY, KJ AF ANDREAS, EL CLAFFEY, KJ TI AIR-ICE DRAG COEFFICIENTS IN THE WESTERN WEDDELL SEA .1. VALUES DEDUCED FROM PROFILE MEASUREMENTS SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID ANTARCTIC PACK ICE; WIND STRESS; SURFACE; SNOW; ROUGHNESS; MOMENTUM; LAYER; HEAT; FLUX AB From 197 hourly averaged, four-level wind speed profiles collected on Ice Station Weddell (ISW) in February and March 1992, we compute the neutral stability, 10-m, air-ice drag coefficient, C-DN10. Values range from 1.3 x 10(-3) to 2.5 x 10(-3) for the multiyear ice floe that was ISW. Individual C-DN10 values depend critically on how well the mean wind is aligned with the dominant snowdrift patterns. On ISW, 20% of the time, we experienced drifting or blowing snow; when the wind speed at 5 m exceeded 8 m s(-1), such wind-driven snow was a virtual certainty. Consequently, the surface was continually changing, drifts were building, drifts were eroding. As the wind continued from a constant direction and the building drifts streamlined the surface, C-DN10 could decrease by as much as 30% in 12 hours. If the wind direction then shifted by as little as 20 degrees, C-DN10 would immediately increase significantly. The implications are that snow-covered sea ice does not present an isotropic surface; it has a preferred direction dictated by the wind's history. Consequently, computing surface stress using an average value for C-DN10 will produce errors of up to 30%. RP ANDREAS, EL (reprint author), USA,COLD REG RES & ENGN LAB,SNOW & ICE BRANCH,72 LYME RD,HANOVER,NH 03755, USA. NR 40 TC 48 Z9 51 U1 0 U2 2 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD MAR 15 PY 1995 VL 100 IS C3 BP 4821 EP 4831 DI 10.1029/94JC02015 PG 11 WC Oceanography SC Oceanography GA QN009 UT WOS:A1995QN00900042 ER PT J AU ANDREAS, EL AF ANDREAS, EL TI AIR-ICE DRAG COEFFICIENTS IN THE WESTERN WEDDELL SEA .2. A MODEL-BASED ON FORM DRAG AND DRIFTING SNOW SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID BOUNDARY-LAYER; WIND STRESS; SURFACE; ROUGHNESS; MOMENTUM AB In part 1 (Andreas and Claffey, this issue) we observed some characteristics of the neutral stability air-ice drag coefficient at a reference height of 10 m (C-DN10) that had not been documented before. Our main conclusion was that wind-driven snow continually alters the sea ice surface; the resulting snowdrifts determine how large C-DN10 is. In particular, part 1 reported three observations that I would like to explain. (1) C-DN10 is near 1.5 x 10(-3) when the wind is well aligned with the drifted snow. (2) C-DN10 is near 2.5 x 10(-3) when the wind makes a large angle with the dominant orientation of the snowdrifts. (3) C-DN10 can increase by 20% if, after being well aligned with the drift patterns, the mean wind direction shifts by as little as 20 degrees. To investigate this behavior of C-DN10, here I adapt a model developed by Raupach (1992) that partitions the total surface stress into contributions from form drag and skin friction. An essential part of this development was extending Raupach's model to the more complex geometry of sastrugi-like roughness elements. Assuming that 10-cm high sastrugi cover 15% of the surface, this physically based model reproduces the three main observations listed above. Thus the model seems to include the basic physics of air-ice momentum exchange. The main conclusion from this modeling is that 10-cm, sastrugi-like snowdrifts, rather than pressure ridges, sustain most of the form drag over compact sea ice in the western Weddell Sea. Secondly, the modeling suggests that skin friction accounts for about 60% of the surface stress when the wind is well aligned with the sastrugi; but when the wind is not well aligned, form drag accounts for about 80% of the stress. The sastrugi are thus quite effective in streamlining the surface. RP ANDREAS, EL (reprint author), USA,COLD REG RES & ENGN LAB,SNOW & ICE BRANCH,72 LYME RD,HANOVER,NH 03755, USA. NR 32 TC 31 Z9 31 U1 0 U2 3 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD MAR 15 PY 1995 VL 100 IS C3 BP 4833 EP 4843 DI 10.1029/94JC02016 PG 11 WC Oceanography SC Oceanography GA QN009 UT WOS:A1995QN00900043 ER PT J AU WANG, RB CHAROENVIT, Y CORRADIN, G PORROZZI, R HUNTER, RL GLENN, G ALVING, CR CHURCH, P HOFFMAN, SL AF WANG, RB CHAROENVIT, Y CORRADIN, G PORROZZI, R HUNTER, RL GLENN, G ALVING, CR CHURCH, P HOFFMAN, SL TI INDUCTION OF PROTECTIVE POLYCLONAL ANTIBODIES BY IMMUNIZATION WITH A PLASMODIUM-YOELII CIRCUMSPOROZOITE PROTEIN MULTIPLE ANTIGEN PEPTIDE VACCINE SO JOURNAL OF IMMUNOLOGY LA English DT Article ID T-CELL EPITOPES; SYNTHETIC PEPTIDE; MALARIA VACCINE; MONOCLONAL-ANTIBODIES; MURINE MALARIA; REPEAT REGION; SURFACE-ANTIGEN; INVITRO ASSAY; FALCIPARUM; SPOROZOITE AB Monoclonal Abs against the repeat region of the circumsporozoite protein (CSP) completely protect mice against Plasmodium yoelii (Py), but synthetic peptide and recombinant protein vaccines designed to produce only Abs to the PyCSP repeat region have never been reported to consistently provide protection. This lack of protection in the rodent model system has predicted the poor protection achieved in humans after immunization with synthetic peptide and recombinant protein P. falciparum CSP vaccines and has raised serious questions regarding the capacity for vaccine-induced polyclonal Abs against the CSP to consistently protect humans. We now report immunization studies with a multiple Ag peptide vaccine designed to rely on ''universal'' T epitopes from tetanus toxin to produce T cell help for induction of protective Abs against the repeat region of the PyCSP. When delivered with a nonionic block co-polymer adjuvant, the vaccine protected 78 to 100% of three inbred strains of mice, and 100% of outbred mice against P. yoelii sporozoite challenge. Protection was associated with Ab titer, and passive transfer of purified IgG from immune mice protected naive recipients. Similar protection was achieved when the peptide was encapsulated in liposomes with lipid A and mixed with aluminum hydroxide. By demonstrating for the first time solid protection against P. yoelii by polyclonal Abs against the CSP, these data provide the rationale for assessment of a similarly constructed and formulated P. falciparum CSP multiple Ag peptide vaccine in humans. C1 USN,MED RES INST,MALARIA PROGRAM,BETHESDA,MD 20889. UNIV LAUSANNE,INST BIOCHEM,CH-1066 EPALINGES,SWITZERLAND. FIOCRUZ MS,DEPT ULTRASTRUCT & CELL BIOL,RIO JANEIRO,BRAZIL. EMORY UNIV,DEPT PATHOL,ATLANTA,GA 30322. WALTER REED ARMY INST RES,DEPT MEMBRANE BIOCHEM,WASHINGTON,DC 20307. NR 51 TC 72 Z9 76 U1 0 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAR 15 PY 1995 VL 154 IS 6 BP 2784 EP 2793 PG 10 WC Immunology SC Immunology GA QL084 UT WOS:A1995QL08400025 PM 7876549 ER PT J AU BARTH, J AF BARTH, J TI THE DIVIDEND CONNECTION - HOW DIVIDENDS CREATE VALUE IN THE STOCK-MARKET - WEISS,G, WEISS,G SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD MAR 15 PY 1995 VL 120 IS 5 BP 84 EP 84 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA QL362 UT WOS:A1995QL36200107 ER PT J AU MANKA, AS SCALORA, M DOWLING, JP BOWDEN, CM AF MANKA, AS SCALORA, M DOWLING, JP BOWDEN, CM TI PULSE-PROPAGATION IN A RAMAN PUMPED, 4-LEVEL MEDIUM THAT EXHIBITS INVERSIONLESS GAIN SO OPTICS COMMUNICATIONS LA English DT Note ID POPULATION-INVERSION; LIGHT AMPLIFICATION; LASER; COHERENCE; DRIVEN; SODIUM; MODEL AB We numerically study the effect of two, coherent, copropagating pulses incident on an atomic beam of identical, homogeneously broadened, four-level atoms. The injected pulses have different frequencies that are nearly resonant with the allowed dipole transitions. The complex polarization that gives rise to gain and dispersion is examined at various field strengths; including strong probe field strengths where standard linear treatments are not valid. We conclude that in contrast to the steady state case, the maximum gain decreases at the sidebands with increasing pump strengths. In the nonlinear regime, where pump and probe are of comparable magnitude, competition between the upper and lower coherences may lead to loss of gain. RP MANKA, AS (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,AMSMI RD WS ST,REDSTONE ARSENAL,AL 35898, USA. RI DOWLING, JONATHAN/L-2749-2013 NR 20 TC 4 Z9 4 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD MAR 15 PY 1995 VL 115 IS 3-4 BP 283 EP 290 DI 10.1016/0030-4018(94)00681-J PG 8 WC Optics SC Optics GA QL915 UT WOS:A1995QL91500011 ER PT J AU JIA, QX ZHENG, JP KWOK, HS ANDERSON, WA AF JIA, QX ZHENG, JP KWOK, HS ANDERSON, WA TI INDIUM TIN OXIDE ON INP BY PULSED-LASER DEPOSITION SO THIN SOLID FILMS LA English DT Article DE ELECTRICAL PROPERTIES AND MEASUREMENTS; INDIUM PHOSPHIDE; LASER ABLATION; PHOTOVOLTAGE ID HOMOJUNCTION SOLAR-CELLS; VAPOR-PHASE EPITAXY; FILMS AB Indium tin oxide (ITO) films with a resistivity of the order of 6 x 10(-4) Omega cm were deposited at room temperature on InP by pulsed laser ablation. The resistivity of the films was further reduced to less than 2 x 10(-4) Omega cm if the deposition was done at a substrate temperature of 310 degrees C. The enhanced blue response of the photovoltaic device of ITO/InP deposited at room temperature indicated improved collection efficiency near the ITO-InP interface. The dark current-voltage measurements indicated higher excess current at lower bias for the devices fabricated at 310 degrees C. C1 USA,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703. SUNY BUFFALO,DEPT ELECT & COMP ENGN,BUFFALO,NY 14260. RP JIA, QX (reprint author), LOS ALAMOS NATL LAB,POB 1663,LOS ALAMOS,NM 87545, USA. RI Jia, Q. X./C-5194-2008 NR 17 TC 10 Z9 10 U1 0 U2 4 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0040-6090 J9 THIN SOLID FILMS JI Thin Solid Films PD MAR 15 PY 1995 VL 258 IS 1-2 BP 260 EP 263 DI 10.1016/0040-6090(94)06362-1 PG 4 WC Materials Science, Multidisciplinary; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA QN158 UT WOS:A1995QN15800040 ER PT J AU MENSHIKOVA, EV RITOV, VB SHVEDOVA, AA ELSAYED, N KAROL, MH KAGAN, VE AF MENSHIKOVA, EV RITOV, VB SHVEDOVA, AA ELSAYED, N KAROL, MH KAGAN, VE TI PULMONARY MICROSOMES CONTAIN A CA2+-TRANSPORT SYSTEM SENSITIVE TO OXIDATIVE STRESS SO BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS LA English DT Article DE ATPASE, CA2+-; CALCIUM ION TRANSPORT; OXIDATIVE STRESS; IRON; ASCORBATE; FERRYLHEMOGLOBIN; ALAMETHICIN; (LUNG); (MICROSOME) ID INTRACELLULAR CALCIUM HOMEOSTASIS; CARDIAC SARCOPLASMIC-RETICULUM; LIPID-PEROXIDATION; INOSITOL TRISPHOSPHATE; CA-2+ CONCENTRATION; IONOPHORE A23187; SKELETAL-MUSCLE; ATPASE ACTIVITY; MESSENGER; LUNG AB A variety of events, including inhalation of atmospheric chemicals, trauma, and ischemia-reperfusion, may cause generation of reactive oxygen species in the lung and result in airways constriction. The specific metabolic mechanisms that translate oxygen radical production into airways constriction are yet to be identified. In the lung, calcium homeostasis is central to release of bronchoactive and vasoactive chemical mediators and to regulation of smooth muscle cell contractility, i.e., airway constriction. In the present work, we characterized Ca2+-transport in the microsomal fraction of mouse lungs, and determined how reactive oxygen species, generated by Fe2+/ascorbate and H2O2/hemoglobin, affected Ca2+ transport. The microsomal fraction of pulmonary tissue accumulated 90 +/- 5 nmol Ca2+/mg protein by an ATP-dependent process in the presence of 15 mM oxalate, and 16 +/- 2 nmol Ca2+ in its absence. In the presence of oxalate, the rate of Ca2+ uptake was 50 +/- 5 nmol Ca2+/min per mg protein at pCa 5.9 (37 degrees C). The Ca2+-ATPase activity was 50-60 nmol P-i/min per mg protein (pCa 5.9, 37 degrees C) in the presence of alamethicin. Inhibitors of mitochondrial H+-ATPase had no effect on the Ca2+ transport. Half-maximal activation of Ca2+ transport was produced by 0.4-0.5 mu M Ca2+. Endoplasmic reticulum Ca2+-pump (SERC-ATPase) was found to be predominantly responsible for the Ca2+-accumulating capacity of the pulmonary microsomes. Incubation of the microsomes in the presence of either Fe2+/ascorbate or H2O2/hemoglobin resulted in a time-dependent accumulation of peroxidation products (TBARS) and in inhibition of the Ca2+ transport. The inhibitory effect of Fe2+/ascorbate on Ca2+ transport strictly correlated with the inhibition of the Ca2+-ATPase activity. These results are the first to indicate a highly active microsomal Ca2+ transport system in murine lungs which is sensitive to endogenous oxidation products. The importance of this system to pulmonary disorders exacerbated by oxidative chemicals remains to be studied. C1 UNIV PITTSBURGH, DEPT ENVIRONM & OCCUPAT HLTH, PITTSBURGH, PA 15238 USA. WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, DEPT RESP RES, WASHINGTON, DC 20307 USA. UNIV CALIF LOS ANGELES, DEPT ENVIRONM & OCCUPAT HLTH, LOS ANGELES, CA USA. FU PHS HHS [5651] NR 58 TC 14 Z9 14 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0005-2728 EI 0006-3002 J9 BBA-BIOENERGETICS JI Biochim. Biophys. Acta-Bioenerg. PD MAR 14 PY 1995 VL 1228 IS 2-3 BP 165 EP 174 DI 10.1016/0005-2728(94)00166-3 PG 10 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA QM744 UT WOS:A1995QM74400003 PM 7893726 ER PT J AU DUREE, G MORIN, M SALAMO, G SEGEV, M CROSIGNANI, B DIPORTO, P SHARP, E YARIV, A AF DUREE, G MORIN, M SALAMO, G SEGEV, M CROSIGNANI, B DIPORTO, P SHARP, E YARIV, A TI DARK PHOTOREFRACTIVE SPATIAL SOLITONS AND PHOTOREFRACTIVE VORTEX SOLITONS SO PHYSICAL REVIEW LETTERS LA English DT Article ID MEDIA; BEAM C1 PRINCETON UNIV,DEPT ELECT ENGN,PRINCETON,NJ 08544. PRINCETON UNIV,ADV CTR PHOTON & OPTOELECTR MAT,PRINCETON,NJ 08544. PRINCETON UNIV,PRINCETON MAT INST,PRINCETON,NJ 08544. UNIV AQUILA,DIPARTIMENTO FIS,LAQUILA,ITALY. USA,RES LAB,FT BELVOIR,VA 22060. CALTECH,PASADENA,CA 91125. RP DUREE, G (reprint author), UNIV ARKANSAS,DEPT PHYS,FAYETTEVILLE,AR 72701, USA. NR 14 TC 157 Z9 158 U1 1 U2 5 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD MAR 13 PY 1995 VL 74 IS 11 BP 1978 EP 1981 DI 10.1103/PhysRevLett.74.1978 PG 4 WC Physics, Multidisciplinary SC Physics GA QL584 UT WOS:A1995QL58400021 ER PT J AU BASSETT, GM WOODWARD, PR AF BASSETT, GM WOODWARD, PR TI SIMULATION OF THE INSTABILITY OF MACH 2-AND MACH-4 GASEOUS JETS IN 2-DIMENSIONS AND 3-DIMENSIONS SO ASTROPHYSICAL JOURNAL LA English DT Article DE GALAXIES, JETS; HYDRODYNAMICS; INSTABILITIES; ISM, JETS AND OUTFLOWS; METHODS, NUMERICAL; SHOCK WAVES; VIDEOTAPES ID SUPERSONIC VORTEX SHEETS; KELVIN-HELMHOLTZ INSTABILITIES; NONLINEAR KINK MODES; NUMERICAL SIMULATIONS; ASTROPHYSICAL JETS; SPATIAL STABILITY; RADIO-SOURCES; ASYMMETRIC MORPHOLOGY; ATMOSPHERIC GRADIENTS; REFLECTION MODES AB Instabilities affecting the propagation of supersonic gaseous jets have been studied using high-resolution computer simulations with the piecewise-parabolic method. These results are discussed in relation to jets from galactic nuclei. These studies involve a detailed treatment of a single section of a very long jet, approximating the dynamics by using periodic boundary conditions. Convergence of the numerical approximations has been tested by comparing jet simulations with different grid resolutions. The effects of initial conditions and geometry on the dominant disruptive instabilities have also been explored. For simulations of periodic jets, the initial velocity perturbations set up zig-zag shock patterns inside the jet. In each case a single zig-zag shock pattern (an odd mode) or a double zig-zag shock pattern (an even mode) grows to dominate the flow. The dominant kink instability responsible for these shock patterns moves approximately at the linear resonance velocity, upsilon(mode) = c(ext) upsilon(rel)/(c(jet) + c(ext)). For high-resolution simulations (those with 150 or more computational zones across the jet width), the even mode dominates if the even perturbation is higher in amplitude initially than the odd perturbation. For low-resolution simulations, the odd mode dominates even for a stronger even mode perturbation. In high-resolution simulations, the jet boundary rolls up and large amounts of external gas are entrained into the jet. In low-resolution simulations, this entrainment process is impeded. Large-amplitude modes take much longer to develop in jets perturbed at one point in space (long, nonperiodic jets) than those with spatially periodic perturbations, but once a dominant mode is established, disruption occurs at essentially the same rate. Except for the presence of small-scale turbulence at low resolution, the three-dimensional jet simulations behave similarly to two-dimensional jet runs. C1 UNIV MINNESOTA, DEPT ASTRON, MINNEAPOLIS, MN 55455 USA. UNIV MINNESOTA, ARMY HIGH PERFORMANCE COMP RES CTR, MINNEAPOLIS, MN 55455 USA. UNIV MINNESOTA, MINNESOTA SUPERCOMP INST, MINNEAPOLIS, MN 55455 USA. NR 52 TC 23 Z9 23 U1 0 U2 1 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0004-637X EI 1538-4357 J9 ASTROPHYS J JI Astrophys. J. PD MAR 10 PY 1995 VL 441 IS 2 BP 582 EP 602 DI 10.1086/175385 PN 1 PG 21 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA QK140 UT WOS:A1995QK14000016 ER PT J AU ANDERSON, DR BYERS, SL CLARK, CR SCHLEHR, JA AF ANDERSON, DR BYERS, SL CLARK, CR SCHLEHR, JA TI CHANGES IN RAT LUNG LAVAGE FLUID FOLLOWING ACUTE SULFUR MUSTARD INHALATION SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 10 PY 1995 VL 9 IS 4 BP A716 EP A716 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QM406 UT WOS:A1995QM40600532 ER PT J AU ASSAAD, A KOKES, J BAVARI, S PITT, L WADE, J WILHELMSEN, C AF ASSAAD, A KOKES, J BAVARI, S PITT, L WADE, J WILHELMSEN, C TI EFFECT OF NEUTROPHIL DEPLETION ON THE PATHOGENESIS OF RICIN INDUCED ACUTE PULMONARY TOXICITY IN RATS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 10 PY 1995 VL 9 IS 4 BP A964 EP A964 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QM406 UT WOS:A1995QM40601974 ER PT J AU ATKINS, J JOHNSON, K SCOTT, Z PEARCE, F AF ATKINS, J JOHNSON, K SCOTT, Z PEARCE, F TI HEMORRHAGE AUGMENTS THE EFFECT OF OXYGEN ON MEAN ARTERIAL BLOOD-PRESSURE (MABP) SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 8 Z9 8 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 10 PY 1995 VL 9 IS 4 BP A890 EP A890 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QM406 UT WOS:A1995QM40601546 ER PT J AU BENTON, BJ SPRIGGS, D DOEBLER, J CHANG, FCT AF BENTON, BJ SPRIGGS, D DOEBLER, J CHANG, FCT TI 4-AMINOPYRIDINE (4-AP) ANTAGONIZES SAXITOXIN (STX) INDUCED LETHALITY SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,DIV PATHOPHYSIOL,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 10 PY 1995 VL 9 IS 4 BP A664 EP A664 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QM406 UT WOS:A1995QM40600234 ER PT J AU BOWERS, W BLAHA, M SANKOVICH, J AF BOWERS, W BLAHA, M SANKOVICH, J TI HEAT-INDUCED RELEASE OF INTERLEUKIN-1-ALPHA (IL-1-ALPHA) AND PROSTAGLANDIN-E(2) (PGE(2)) FROM ARTIFICIAL HUMAN SKIN SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 10 PY 1995 VL 9 IS 4 BP A708 EP A708 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QM406 UT WOS:A1995QM40600485 ER PT J AU BYERS, CE CAPACIO, BR CHANG, FCT MATTHEWS, RL AF BYERS, CE CAPACIO, BR CHANG, FCT MATTHEWS, RL TI AN HPLC METHOD FOR THE DETERMINATION OF 4-AMINOPYRIDINE IN GUINEA-PIG PLASMA SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,DIV PHARMACOL,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 1 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 10 PY 1995 VL 9 IS 4 BP A687 EP A687 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QM406 UT WOS:A1995QM40600363 ER PT J AU CAPACIO, BR CHANG, FCT SPRIGGS, D BYERS, CE MATTHEWS, RL AF CAPACIO, BR CHANG, FCT SPRIGGS, D BYERS, CE MATTHEWS, RL TI PHARMACOKINETICS AND PHARMACODYNAMICS OF 4-AMINO-PYRIDINE IN GUINEA-PIGS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,DIV PHARMACOL,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 10 PY 1995 VL 9 IS 4 BP A687 EP A687 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QM406 UT WOS:A1995QM40600366 ER PT J AU CHANG, FCT BENTON, BJ CAPACIO, BR SPRIGGS, D AF CHANG, FCT BENTON, BJ CAPACIO, BR SPRIGGS, D TI 4-AMINOPYRIDINE (4-AP) REVERSES THE SUBLETHAL EFFECTS OF SAXITOXIN (STX) AND TETRODOTOXIN (TTX) SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,DIV PATHOPHYSIOL,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 10 PY 1995 VL 9 IS 4 BP A664 EP A664 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QM406 UT WOS:A1995QM40600231 ER PT J AU DUBICK, MA GRETZ, D BROOKS, DE JANSSEN, CM SCHAEFFER, MC AF DUBICK, MA GRETZ, D BROOKS, DE JANSSEN, CM SCHAEFFER, MC TI SKIN WOUND-HEALING IN RATS FED DIFFERENT VITAMIN-B-6 (PYRIDOXINE) DIETS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST SURG RES,SAN ANTONIO,TX 78234. USDA ARS,SAN FRANCISCO,CA 94129. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 10 PY 1995 VL 9 IS 4 BP A986 EP A986 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QM406 UT WOS:A1995QM40602103 ER PT J AU DUBOSE, DA GAFFIN, S SHIPPEE, RL AF DUBOSE, DA GAFFIN, S SHIPPEE, RL TI COMPARISON BETWEEN ENDOTOXIN (ET) AND HYPERTHERMIA (HT) ON THE CYTOKINE RESPONSE (CR) BY HUMAN WHOLE-BLOOD (HWB) UNDER IN-VITRO CONDITIONS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 10 PY 1995 VL 9 IS 4 BP A709 EP A709 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QM406 UT WOS:A1995QM40600491 ER PT J AU FULCO, CS LEWIS, SF FRYKMAN, P BOUSHEL, R SMITH, S HARMAN, E CYMERMAN, A PANDOLF, KB AF FULCO, CS LEWIS, SF FRYKMAN, P BOUSHEL, R SMITH, S HARMAN, E CYMERMAN, A PANDOLF, KB TI FATIGUE IN DYNAMIC LEG EXERCISE UNDER CONDITIONS OF HYPOBARIC HYPOXIA SO FASEB JOURNAL LA English DT Meeting Abstract C1 BOSTON UNIV,BOSTON,MA 02215. USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 10 PY 1995 VL 9 IS 4 BP A647 EP A647 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QM406 UT WOS:A1995QM40600132 ER PT J AU GORBOUNOV, M OSIPOV, A DAY, B KAGAN, V ELSAYED, N AF GORBOUNOV, M OSIPOV, A DAY, B KAGAN, V ELSAYED, N TI NITRIC-OXIDE PROTECTS FROM OXIDATIVE STRESS BY REDUCING FERRYL MYOGLOBIN AND FERRYL HEMOGLOBIN RADICALS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. UNIV CALIF LOS ANGELES,LOS ANGELES,CA. UNIV PITTSBURGH,PITTSBURGH,PA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 10 PY 1995 VL 9 IS 4 BP A892 EP A892 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QM406 UT WOS:A1995QM40601555 ER PT J AU HEWETSON, JF ASSAAD, AW KOKES, JM TETERS, DR AF HEWETSON, JF ASSAAD, AW KOKES, JM TETERS, DR TI RICIN-SPECIFIC ANTIBODIES IN THE BRONCHIOAVEOLAR LAVAGE (BAL) OF RATS IMMUNIZED WITH A GMP RICIN TOXOID PROTECT AGAINST INHALED RICIN SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 10 PY 1995 VL 9 IS 4 BP A685 EP A685 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QM406 UT WOS:A1995QM40600352 ER PT J AU JOHNSON, K CHARYA, R WIESMANN, W PEARCE, F AF JOHNSON, K CHARYA, R WIESMANN, W PEARCE, F TI H-2-RECEPTOR ANTAGONISM WITH CIMETIDINE (CIM) AND FAMOTIDINE (FAM) DURING HEMORRHAGIC-SHOCK (HS) IN THE RAT SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 10 PY 1995 VL 9 IS 4 BP A889 EP A889 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QM406 UT WOS:A1995QM40601541 ER PT J AU KAMIMORI, GH DAVIS, HQ BALKIN, TJ SANTAROMANA, M THORNE, DA LAWLESS, N AF KAMIMORI, GH DAVIS, HQ BALKIN, TJ SANTAROMANA, M THORNE, DA LAWLESS, N TI RELATIONSHIP BETWEEN PAO2, ACUTE MOUNTAIN-SICKNESS (AMS), AND COGNITIVE PERFORMANCE DURING 8 HRS OF SEVERE HYPOXIA IN MALES SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 10 PY 1995 VL 9 IS 4 BP A648 EP A648 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QM406 UT WOS:A1995QM40600137 ER PT J AU KRAKAUER, T AF KRAKAUER, T TI DIFFERENTIAL INHIBITORY EFFECTS OF INTERLEUKIN-10, INTERLEUKIN-4 AND DEXAMETHASONE ON STAPHYLOCOCCAL ENTEROTOXIN-INDUCED CYTOKINE PRODUCTION AND T-CELL ACTIVATION SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 10 PY 1995 VL 9 IS 4 BP A822 EP A822 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QM406 UT WOS:A1995QM40601143 ER PT J AU LYONS, TP FREUND, BJ YOUNG, AJ SAWKA, MN MUZA, SR CYMERMAN, A VALERI, CR DELANY, JP AF LYONS, TP FREUND, BJ YOUNG, AJ SAWKA, MN MUZA, SR CYMERMAN, A VALERI, CR DELANY, JP TI ERYTHROCYTE INFUSION EFFECTS ON FLUID REDISTRIBUTION AT HIGH-ALTITUDE SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 10 PY 1995 VL 9 IS 4 BP A650 EP A650 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QM406 UT WOS:A1995QM40600147 ER PT J AU MARCHITELLI, LJ WESTPHAL, KA FRIEDL, KE SHARP, MA AF MARCHITELLI, LJ WESTPHAL, KA FRIEDL, KE SHARP, MA TI RELATIONSHIP BETWEEN MILITARY BODY-FAT STANDARDS, PHYSICAL-FITNESS, AND CARDIOVASCULAR RISK-FACTORS IN FEMALE SOLDIERS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 10 PY 1995 VL 9 IS 4 BP A1013 EP A1013 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QM406 UT WOS:A1995QM40602252 ER PT J AU MATTHEW, CB GENTILE, BJ AF MATTHEW, CB GENTILE, BJ TI COMPARISON OF SPECIFIC PATHOGEN-FREE (SPF) AND CONVENTIONAL RATS UNDER EXPERIMENTAL STRESSORS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 10 PY 1995 VL 9 IS 4 BP A644 EP A644 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QM406 UT WOS:A1995QM40600116 ER PT J AU QIAO, YR KOMISAR, J TSENG, JN AF QIAO, YR KOMISAR, J TSENG, JN TI THE ROLE OF POLYMORPHONUCLEAR LEUKOCYTES (PMNS) IN PULMONARY INJURY CAUSED BY THE SUPERANTIGEN STAPHYLOCOCCAL-ENTEROTOXIN-B (SEB) SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT EXPTL PATHOL,WASHINGTON,DC 20307. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 10 PY 1995 VL 9 IS 4 BP A963 EP A963 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QM406 UT WOS:A1995QM40601972 ER PT J AU SHIPPEE, R WOOD, S ANDERSON, P KRAMER, T NEITA, M WOLCOTT, K AF SHIPPEE, R WOOD, S ANDERSON, P KRAMER, T NEITA, M WOLCOTT, K TI EFFECTS OF GLUTAMINE SUPPLEMENTATION ON IMMUNOLOGICAL RESPONSES OF SOLDIERS DURING THE SPECIAL FORCES ASSESSMENT AND SELECTION COURSE SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. USDA,BELTSVILLE,MD 20705. ROSS LABS,COLUMBUS,OH 43215. USA,INST SURG RES,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 10 PY 1995 VL 9 IS 4 BP A731 EP A731 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QM406 UT WOS:A1995QM40600617 ER PT J AU SHIRAKI, K TORII, R SAGAWA, S ENDO, Y WADA, F NAGAYA, K YAMAZAKI, F LIN, YC CLAYBAUGH, JR AF SHIRAKI, K TORII, R SAGAWA, S ENDO, Y WADA, F NAGAYA, K YAMAZAKI, F LIN, YC CLAYBAUGH, JR TI CHANGES IN CENTRAL VENOUS-PRESSURE AND VASOPRESSIN IN HUMANS DURING EXPOSURE AT 3 ATM ABS AIR SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV HAWAII,HONOLULU,HI 96822. UNIV OCCUPAT & ENVIRONM HLTH,SCH MED,DEPT PHYSIOL,KITAKYUSHU,FUKUOKA 807,JAPAN. TRIPLER ARMY MED CTR,HONOLULU,HI 96859. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 10 PY 1995 VL 9 IS 4 BP A644 EP A644 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QM406 UT WOS:A1995QM40600113 ER PT J AU SMITH, SA HOYT, RW STAAB, JS LEWIS, SF WREN, JA AF SMITH, SA HOYT, RW STAAB, JS LEWIS, SF WREN, JA TI EFFECT OF HIGH-ALTITUDE ACCLIMATIZATION ON MUSCLE PHOSPHATE AND KINETICS DURING STATIC EXERCISE AND RECOVERY SO FASEB JOURNAL LA English DT Meeting Abstract C1 BOSTON UNIV,BOSTON,MA 02215. USA,ENVIRONM MED RES INST,NATICK,MA 01760. MIT,CAMBRIDGE,MA 02139. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 10 PY 1995 VL 9 IS 4 BP A647 EP A647 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QM406 UT WOS:A1995QM40600134 ER PT J AU VASSILOPOULOS, D KOVACS, B TSOKOS, GC AF VASSILOPOULOS, D KOVACS, B TSOKOS, GC TI T-CELL RECEPTOR CD3 COMPLEX-MEDIATED SIGNAL-TRANSDUCTION PATHWAY IN T-CELLS AND T-CELL LINES FROM PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 10 PY 1995 VL 9 IS 4 BP A1029 EP A1029 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QM406 UT WOS:A1995QM40602345 ER PT J AU ADLER, P WOOD, SJ LEE, YC LEE, RT PETRI, WA SCHNAAR, RL AF ADLER, P WOOD, SJ LEE, YC LEE, RT PETRI, WA SCHNAAR, RL TI HIGH-AFFINITY BINDING OF THE ENTAMOEBA-HISTOLYTICA LECTIN TO POLYVALENT N-ACETYLGALACTOSAMINIDES SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID ADHERENCE LECTIN; CLUSTER GLYCOSIDES; HUMAN-ERYTHROCYTES; COLONIC MUCINS; RECEPTOR; SUBUNIT; RAT; PROTEINS; LIGANDS; LIVER AB Entamoeba histolytica trophozoites initiate pathogenic colonization by adherence to host glycoconjugates via an amebic surface lectin which binds to galactose (Gal) and N-acetylgalactosamine (GalNAc) residues. Monovalent and multivalent carbohydrate ligands were screened for inhibition of E. histolytica lectin-mediated human red cell hemagglutination, revealing that: (i) the synthetic multivalent neoglycoprotein GalNAc(39)BSA (having an average of 39 GalNAc residues linked to bovine serum albumin) was 140,000-fold more potent an inhibitor than monovalent GalNAc and 500,000-fold more potent than monovalent Gal; and (ii) small synthetic multivalent ligands which bind with high affinity to the mammalian hepatic Gal/GalNAc lectin do not bind with high affinity to the E. histolytica lectin. Radioligand binding studies revealed saturable binding of I-125-GalNAc(39)BSA to E. histolytica membranes (K-D = 10 +/- 3 nM, B-max = 0.9 +/- 0.08 pmol/mg membrane protein). Maximal binding required the presence of calcium chloride (300 mu M) or sodium chloride (50 mM), and had a broad pH maximum (pH 6-9), GalNAc(39)BSA was 200,000-fold more potent than monovalent GalNAc in blocking radio ligand binding, Among synthetic saccharide-derivatized linear polymers, the GalNAc beta and GalNAc alpha 3Gal beta derivatives were the most potent, with GalNAc alpha and GalNAc alpha 3(Fuc alpha 2)Gal beta derivatives much weaker. The data support a model in which a unique pattern of spaced multiple GalNAc residues are the highest affinity targets for the E. histolytica lectin. C1 JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL & MOLEC SCI,BALTIMORE,MD 21205. USA,CHEM RES DEV COMMAND,ABERDEEN PROVING GROUND,MD 21010. JOHNS HOPKINS UNIV,DEPT BIOL,BALTIMORE,MD 21218. UNIV VIRGINIA,SCH MED,DEPT MED,CHARLOTTESVILLE,VA 22908. UNIV VIRGINIA,SCH MED,DEPT PATHOL & MICROBIOL,CHARLOTTESVILLE,VA 22908. RI Schnaar, Ronald/S-8967-2016 OI Schnaar, Ronald/0000-0002-7701-5484 FU NIAID NIH HHS [AI-26649] NR 28 TC 73 Z9 74 U1 0 U2 2 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD MAR 10 PY 1995 VL 270 IS 10 BP 5164 EP 5171 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA QL580 UT WOS:A1995QL58000034 PM 7890626 ER PT J AU WERRLEIN, RJ MADRENWHALLEY, JS KIRBY, SD AF WERRLEIN, RJ MADRENWHALLEY, JS KIRBY, SD TI DENDRITIC-CELL TRANSFORMATION AND EXPRESSION OF OX-6 BY A PHOSGENE-SENSITIVE PROGENITOR GROWN FROM RAT TRACHEAL EXPLANTS SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD MAR 10 PY 1995 SU 21A BP 22 EP 22 PG 1 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA QT864 UT WOS:A1995QT86400074 ER PT J AU WHITE, KL KRZYCH, U AF WHITE, KL KRZYCH, U TI T-CELL ACTIVATION BY SPOROZOITE VS CSP PROTEIN-SPECIFIC PEPTIDES SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307. CATHOLIC UNIV AMER,WASHINGTON,DC 20026. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD MAR 10 PY 1995 SU 21A BP 23 EP 23 PG 1 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA QT864 UT WOS:A1995QT86400075 ER PT J AU DEFRANK, JJ CHENG, TC KOLAKOWSKI, E HARVEY, SP AF DEFRANK, JJ CHENG, TC KOLAKOWSKI, E HARVEY, SP TI ADVANCES IN THE BIODEGRADATION OF CHEMICAL WARFARE AGENTS AND RELATED MATERIALS SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Meeting Abstract C1 USA,CTR,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 1 Z9 1 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD MAR 10 PY 1995 SU 21A BP 41 EP 41 PG 1 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA QT864 UT WOS:A1995QT86400138 ER PT J AU MELLO, CM SZAFRANSKI, P SANO, T SMITH, CL CANTOR, CR KAPLAN, DL AF MELLO, CM SZAFRANSKI, P SANO, T SMITH, CL CANTOR, CR KAPLAN, DL TI GENETIC CONSTRUCTS FOR HAZARDOUS MATERIALS SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Meeting Abstract C1 USA,NATICK RD&E CTR,DIV BIOTECHNOL,NATICK,MA 01760. BOSTON UNIV,CTR ADV BIOTECHNOL,BOSTON,MA 02215. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD MAR 10 PY 1995 SU 21A BP 44 EP 44 PG 1 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA QT864 UT WOS:A1995QT86400146 ER PT J AU KIM, JH SITZ, KV RATTO, S MCLINDEN, RJ DAVIS, K BURKE, DS BOSWELL, RN MOSCA, JD REDFIELD, RR BIRX, DL AF KIM, JH SITZ, KV RATTO, S MCLINDEN, RJ DAVIS, K BURKE, DS BOSWELL, RN MOSCA, JD REDFIELD, RR BIRX, DL TI ANTIGEN-INDUCIBLE EXPRESSION OF AN EXOGENOUS IL-7 GENE IN HUMAN, ANTIGEN-SPECIFIC T-CELLS SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Meeting Abstract C1 HENRY M JACKSON FDN,ROCKVILLE,MD. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD MAR 10 PY 1995 SU 21A BP 396 EP 396 PG 1 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA QT864 UT WOS:A1995QT86401433 ER PT J AU RATTO, S SITZ, KV SCHERER, AM KIM, JH BIRX, DL AF RATTO, S SITZ, KV SCHERER, AM KIM, JH BIRX, DL TI HIV-1 ENVELOPE-SPECIFIC CD4+ T-LYMPHOCYTE LINES AND CLONES AS TOOLS FOR GENE-THERAPY SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Meeting Abstract C1 HM JACKSON FDN,ROCKVILLE,MD 20850. WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD 20850. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD MAR 10 PY 1995 SU 21A BP 399 EP 399 PG 1 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA QT864 UT WOS:A1995QT86401445 ER PT J AU CLINE, A JANSEN, G MELBY, C AF CLINE, A JANSEN, G MELBY, C TI STRESS-FRACTURES IN FEMALE ARMY RECRUITS - IMPLICATIONS OF EXERCISE, CALCIUM INTAKE AND BONE-DENSITY SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. COLORADO STATE UNIV,FT COLLINS,CO 80523. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP 162 EP 162 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98700968 ER PT J AU ARENDT, MA RUBAL, BJ AF ARENDT, MA RUBAL, BJ TI ACUTE EFFECTS OF PARENTERAL MGSO, ON CARDIAC CONDUCTION TIMES AND HEMODYNAMICS DURING RIGHT ATRIAL-PACING SO FASEB JOURNAL LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A604 EP A604 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98703526 ER PT J AU BAKERFULCO, CJ BUCHBINDER, JC TORRI, SA AF BAKERFULCO, CJ BUCHBINDER, JC TORRI, SA TI DIETARY INTAKES OF MARINES ON LIBERTY SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A176 EP A176 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98701052 ER PT J AU BHAT, KR RAY, R AF BHAT, KR RAY, R TI SULFUR MUSTARD (HD) CAUSES DNA-LIGASE ACTIVATION IN NORMAL HUMAN EPIDERMAL-KERATINOCYTES (NHEK) SO FASEB JOURNAL LA English DT Meeting Abstract C1 LINCOLN UNIV,DEPT CHEM,LINCOLN,PA 19352. USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 2 Z9 2 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A425 EP A425 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98702487 ER PT J AU BURLESON, DG MASON, AD PRUITT, BA AF BURLESON, DG MASON, AD PRUITT, BA TI CHANGES IN LYMPHOCYTE SURFACE-ANTIGENS THAT PRECEDE INFECTION IN BURNED PATIENTS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST SURG RES,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A520 EP A520 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98703037 ER PT J AU CARETTI, DM KUHLMANN, WD AF CARETTI, DM KUHLMANN, WD TI RESISTANCE BREATHING CURING EXERCISE ALTERS VENTILATORY PATTERNS AND RESPIRATORY TIMING SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,EDGEWOOD RD&E CTR,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A360 EP A360 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98702111 ER PT J AU CLAYBAUGH, JR SATO, AK VANSCOY, SC AF CLAYBAUGH, JR SATO, AK VANSCOY, SC TI EFFECTS OF HYPEROXIA AND HYPOXIA ON CARDIOPULMONARY AND HORMONAL RESPONSES TO HEMORRHAGE SO FASEB JOURNAL LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A265 EP A265 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98701559 ER PT J AU COURTNEY, B SCHLAGER, I AF COURTNEY, B SCHLAGER, I TI A DEGENERATIVE PRIMER SET FOR PCR AMPLIFICATION OF THE MURINE IMMUNOGLOBULIN IN HEAVY-CHAIN VARIABLE REGION AND DIAGNOSTIC PRIMERS FOR PCR AMPLIFICATION CONDITIONS AND RNA QUALITY SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A411 EP A411 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98702403 ER PT J AU DROST, AC MOORE, R MASON, AD PRUITT, BA CIOFFI, WG AF DROST, AC MOORE, R MASON, AD PRUITT, BA CIOFFI, WG TI ALTERED GRANULOCYTE H2O2 RELEASE FOLLOWING SEVERE THERMAL-INJURY SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST SURG RES,FT SAM HOUSTON,TX 78234. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A227 EP A227 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98701343 ER PT J AU FRIEDL, KE WESTPHAL, KA MARCHITELLI, LJ AF FRIEDL, KE WESTPHAL, KA MARCHITELLI, LJ TI REPRODUCTIVE STATUS AND MENSTRUAL CYCLICITY OF PREMENOPAUSAL WOMEN IN ARMY BASIC COMBAT TRAINING (BCT) SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,DIV OCCUPAT PHYSIOL,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A292 EP A292 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98701717 ER PT J AU GABAREE, CLV STEPHENSON, LA KOLKA, MA AF GABAREE, CLV STEPHENSON, LA KOLKA, MA TI COMPARISON OF LASER-DOPPLER FLOWMETRY (LDF) AND VENOUS OCCLUSION PLETHYSMOGRAPHY (VOP) MEASUREMENTS OF SKIN BLOOD-FLOW SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A360 EP A360 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98702108 ER PT J AU GOODWIN, C WHITSON, J PRUITT, BA AF GOODWIN, C WHITSON, J PRUITT, BA TI ALTERED MITOCHONDRIAL FAT-METABOLISM IN HYPERMETABOLIC INJURED RAT SO FASEB JOURNAL LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,INST SURG RES,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A477 EP A477 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98702786 ER PT J AU KOKES, J HEWETSON, J WILHELMSEN, C PITT, L ASSAAD, A AF KOKES, J HEWETSON, J WILHELMSEN, C PITT, L ASSAAD, A TI A GMP RICIN TOXOID ATTENUATES ACUTE PULMONARY TOXICITY IN RATS EXPOSED TO A LETHAL DOSE OF RICIN AEROSOL SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702. USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A431 EP A431 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98702521 ER PT J AU KOLKA, MA STEPHENSON, LA AF KOLKA, MA STEPHENSON, LA TI SKIN BLOOD NOW MEASURED BY LASER-DOPPLER FLOWMETRY AND VENOUS OCCLUSION PLETHESMOGRAPHY - PHYSIOLOGICAL AND METHODOLOGICAL CONSIDERATIONS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A357 EP A357 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98702095 ER PT J AU KOVACS, B TSOKOS, GC AF KOVACS, B TSOKOS, GC TI CROSS-LINKING OF FAS/APO1 ANTIGEN SUPPRESSES THE CD3-MEDIATED SIGNAL-TRANSDUCTION IN HUMAN T-LYMPHOCYTES SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A197 EP A197 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98701172 ER PT J AU LEWIS, SF FULCO, CS FRYKMAN, P BOUSHEL, R SMITH, S HARMAN, E CYMERMAN, A PANDOLF, KB AF LEWIS, SF FULCO, CS FRYKMAN, P BOUSHEL, R SMITH, S HARMAN, E CYMERMAN, A PANDOLF, KB TI MUSCLE FATIGUE DOES NOT IMPACT PRESSOR AND HEART-RATE RESPONSES DURING DYNAMIC LEG EXERCISE SO FASEB JOURNAL LA English DT Meeting Abstract C1 BOSTON UNIV,BOSTON,MA 02215. USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 1 Z9 1 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A360 EP A360 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98702110 ER PT J AU LUCHETTI, JM HASHIRO, GM NAKAMURA, KT UYEHARA, CFT AF LUCHETTI, JM HASHIRO, GM NAKAMURA, KT UYEHARA, CFT TI COMPARISON OF NITRIC-OXIDE SYNTHASE (NOS) ISOFORMS AND THEIR INFLUENCE ON VASOPRESSIN (VP) ACTION DURING HYPOXIA SO FASEB JOURNAL LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. KAPIOLANI MED CTR,HONOLULU,HI 96826. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A265 EP A265 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98701562 ER PT J AU MACDONALD, VW CHAVEZ, MD RUDOLPH, AS AF MACDONALD, VW CHAVEZ, MD RUDOLPH, AS TI LIPOSOME ENCAPSULATION DOES NOT IMPEDE INTERACTIONS OF HEMOGLOBIN WITH NITRIC-OXIDE SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. USN,RES LAB,CTR BIOMOLEC SCI & ENGN,WASHINGTON,DC 20375. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A27 EP A27 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98700153 ER PT J AU MATYAS, GR ALVING, CR AF MATYAS, GR ALVING, CR TI PRODUCTION OF SERUM IGA AND HIGH-TITER IGG ANTIBODIES BY INTRANASAL IMMUNIZATION WITH LIPOSOME-ENCAPSULATED RICIN SUBUNITS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT MEMBRANE BIOCHEM,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A216 EP A216 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98701278 ER PT J AU MCPHERSON, JC TOBIAS, SW WILLIAMS, LE CHUANG, AH MCPHERSON, JC AF MCPHERSON, JC TOBIAS, SW WILLIAMS, LE CHUANG, AH MCPHERSON, JC TI RED-BLOOD-CELL DEFORMABILITY FOLLOWING PROPYLENE-GLYCOL FEEDING IN RATS SO FASEB JOURNAL LA English DT Meeting Abstract C1 MED COLL GEORGIA,AUGUSTA,GA 30912. EISENHOWER ARMY MED CTR,FT GORDON,GA 30905. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A365 EP A365 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98702138 ER PT J AU MONTAIN, SJ KAIN, JE SAWKA, MN AF MONTAIN, SJ KAIN, JE SAWKA, MN TI REFLEX SWEATING RESPONSE TO DRINKING DURING EXERCISE - EFFECT OF HYPOHYDRATION LEVEL SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A357 EP A357 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98702092 ER PT J AU MUZA, SR YOUNG, AJ SAWKA, MN FORTE, VA KENNEY, JL ROCK, PB LYONS, T FULCO, CS CYMERMAN, A AF MUZA, SR YOUNG, AJ SAWKA, MN FORTE, VA KENNEY, JL ROCK, PB LYONS, T FULCO, CS CYMERMAN, A TI BIPHASIC VENTILATORY RESPONSE TO POIKILOCAPNIC HYPOXIA IS NOT DIMINISHED DURING HIGH-ALTITUDE RESIDENCE SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A566 EP A566 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98703305 ER PT J AU NARAYAN, KA PORCELLA, C SHAW, C AF NARAYAN, KA PORCELLA, C SHAW, C TI THE EFFECT OF HIGH-TEMPERATURE STORAGE ON THE DIGESTIBILITY OF CARBOHYDRATES IN POUCH BREAD SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A454 EP A454 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98702656 ER PT J AU STEPHENSON, LA KOLKA, MA AF STEPHENSON, LA KOLKA, MA TI ENDOGENOUS 17-BETA-ESTRADIOL DECREASES CORE TEMPERATURE THRESHOLD FOR SWEATING IN WOMEN SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 3 Z9 3 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A357 EP A357 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98702094 ER PT J AU THOMAS, V GROPPER, SS AF THOMAS, V GROPPER, SS TI EFFECTS OF CHROMIUM SUPPLEMENTS ON PLASMA-LIPID PROFILES IN HUMANS SO FASEB JOURNAL LA English DT Meeting Abstract C1 AUBURN UNIV,AUBURN,AL 36849. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A578 EP A578 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98703372 ER PT J AU TOLNAY, M LAMBRIS, JD TSOKOS, GC AF TOLNAY, M LAMBRIS, JD TSOKOS, GC TI REGULATION OF COMPLEMENT RECEPTOR-2 (CR-2) EXPRESSION IN HUMAN B-LYMPHOBLASTOID CELL (BLC) LINES SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. UNIV PENN,DEPT PATHOL,PHILADELPHIA,PA 19104. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A212 EP A212 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98701255 ER PT J AU UYEHARA, CFT MATSUDA, LS AF UYEHARA, CFT MATSUDA, LS TI EFFECT OF EARLY TREATMENT WITH NATRIURETIC AGENTS ON HYPERTENSION (HT) DEVELOPMENT IN SPONTANEOUSLY HYPERTENSIVE RATS (SHR) SO FASEB JOURNAL LA English DT Meeting Abstract C1 KAPIOLANI MED CTR,HONOLULU,HI 96826. TRIPLER ARMY MED CTR,HONOLULU,HI 96859. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A335 EP A335 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98701966 ER PT J AU VANSCOY, SC CLAYBAUGH, JR UYEHARA, CFT SATO, AK NAKAMURA, KT AF VANSCOY, SC CLAYBAUGH, JR UYEHARA, CFT SATO, AK NAKAMURA, KT TI IMPROVED OXYGEN DELIVERY IN HYPOXIC NEONATAL PIGLETS WITH COMBINATION INFUSION OF VASOPRESSIN V1-AGONIST (V1) AND DOBUTAMINE (DB) SO FASEB JOURNAL LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. KAPIOLANI MED CTR,HONOLULU,HI 96826. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A265 EP A265 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98701560 ER PT J AU WESTPHAL, KA MARCHITELLI, LJ FRIEDL, KE SHARP, MA AF WESTPHAL, KA MARCHITELLI, LJ FRIEDL, KE SHARP, MA TI RELATIONSHIP BETWEEN IRON STATUS AND PHYSICAL PERFORMANCE IN FEMALE SOLDIERS DURING US-ARMY BASIC COMBAT TRAINING SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A361 EP A361 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98702117 ER PT J AU WILHELMSEN, C ASSAAD, A KOKES, J AF WILHELMSEN, C ASSAAD, A KOKES, J TI BLOOD-COAGULATION PARAMETERS AND MICROSCOPIC LESIONS OF RATS WITH INTRAVENOUS RICIN INTOXICATION SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 9 PY 1995 VL 9 IS 3 BP A425 EP A425 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA QL987 UT WOS:A1995QL98702489 ER PT J AU ROBERTSON, DL SHARP, PM MCCUTCHAN, FE HAHN, BH AF ROBERTSON, DL SHARP, PM MCCUTCHAN, FE HAHN, BH TI RECOMBINATION IN HIV-1 SO NATURE LA English DT Letter ID GENES C1 UNIV NOTTINGHAM HOSP,QUEENS MED CTR,DEPT GENET,NOTTINGHAM NG7 2UH,ENGLAND. WALTER REED ARMY INST RES,HENRY M JACKSON FDN,ROCKVILLE,MD 20850. WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD 20850. UNIV ALABAMA,DEPT MED,BIRMINGHAM,AL 35294. UNIV ALABAMA,DEPT MICROBIOL,BIRMINGHAM,AL 35294. RI Sharp, Paul/F-5783-2010 OI Sharp, Paul/0000-0001-9771-543X NR 10 TC 486 Z9 506 U1 0 U2 6 PU MACMILLAN MAGAZINES LTD PI LONDON PA 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF SN 0028-0836 J9 NATURE JI Nature PD MAR 9 PY 1995 VL 374 IS 6518 BP 124 EP 126 DI 10.1038/374124b0 PG 3 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA QL397 UT WOS:A1995QL39700041 PM 7877682 ER PT J AU LIN, AJ MILLER, RE AF LIN, AJ MILLER, RE TI ANTIMALARIAL ACTIVITY OF NEW DIHYDROARTEMISININ DERIVATIVES .6. ALPHA-ALKYLBENZYLIC ETHERS SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID PLASMODIUM-FALCIPARUM; HEPATIC-METABOLISM; ARTEMISININ DRUGS; INVITRO AB A series of diastereomeric dihydroartemisinin alpha-alkylbenzylic ethers was synthesized in search for analogs with higher antimalarial efficacy and longer plasma half-life than the existing artemisinin derivatives. Artelinic acid was used as the model molecule for the design of new analogs. Two approaches were taken in an attempt to (a) increase the lipophilicity of the molecule and (b) decrease the rate of oxidative dealkylation of the target compounds. All compounds in this study showed at least equal or better in vitro antimalarial activity against Plasmodium falciparum than artelinic acid. The most active compounds of this series showed 10-, 20-, and 40-fold better inhibitory activity than artemether, artemisinin, and artelinic acid, respectively. Compounds which have a small methyl group substituted at the alpha-methylene group showed weaker activity than compounds with a larger carbethoxyalkyl substituent, indicating that the lipophilicity and the steric effect of the molecules play important roles in their antimalarial activity. This fact is further substantiated by the significantly weaker antimalarial activity of the carboxylic acids than their corresponding esters. Compounds with electron-withdrawing function (NO2) substantially increase the antimalarial activity. The S-diastereomers, in general, are severalfold more potent than the corresponding R-isomer. RP LIN, AJ (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 25 TC 51 Z9 53 U1 0 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD MAR 3 PY 1995 VL 38 IS 5 BP 764 EP 770 DI 10.1021/jm00005a004 PG 7 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA QL254 UT WOS:A1995QL25400004 PM 7877142 ER PT J AU HOFF, SM AF HOFF, SM TI APPLYING ADVANCED MATERIALS TO TURBOSHAFT ENGINES SO AEROSPACE ENGINEERING LA English DT Article RP HOFF, SM (reprint author), USA,AVIAT APPL TECHNOL DIRECTORATE,WASHINGTON,DC 20310, USA. NR 0 TC 7 Z9 7 U1 0 U2 2 PU SOC AUTOMOTIVE ENG INC PI WARRENDALE PA 400 COMMONWEALTH DRIVE, WARRENDALE, PA 15096 SN 0736-2536 J9 AEROSPACE ENG JI Aerosp. Eng. PD MAR PY 1995 VL 15 IS 2 BP 27 EP 30 PG 4 WC Engineering, Aerospace SC Engineering GA QL600 UT WOS:A1995QL60000006 ER PT J AU DAUGHTRY, CST MCMURTREY, JE CHAPPELLE, EW DULANEY, WP IRONS, JR SATTERWHITE, MB AF DAUGHTRY, CST MCMURTREY, JE CHAPPELLE, EW DULANEY, WP IRONS, JR SATTERWHITE, MB TI POTENTIAL FOR DISCRIMINATING CROP RESIDUES FROM SOIL BY REFLECTANCE AND FLUORESCENCE SO AGRONOMY JOURNAL LA English DT Article ID COVER AB Crop residues left in the field after harvest can be important in controlling soil erosion. Current methods for quantifying percent crop residue cover are tedious and somewhat subjective. There is a need for new methods to quantify residue cover that are rapid, accurate, and objective. We evaluated reflectance and fluorescence techniques for discriminating crop residues from a wide range of soils. Reflectance and fluorescence spectra of 37 agricultural soils (wet and dry) and of recently harvested and weathered corn (Zea mays L.), soybean [Glycine mar (L.) Mere], sorghum [Sorghum bicolor (L.) Moench], and wheat (Triticum aestivum L.) residues were measured in the lab. Reflectance factors in the visible or near-infrared wavelengths did not uniquely distinguish all soils from all crop residues. Crop residues may be brighter or darker than a given soil, depending on soil moisture and residue age. When illuminated with ultraviolet radiation, however, the crop residues fluoresced more than most of the soils. Fluorescence of crop residues was a broad-band phenomenon centered between 420 to 520 nm and induced by a relatively broad range of excitation wavelengths centered between 350 to 400 nm. More than 90% of the crop residues <2 yr old could be discriminated from 33 of 37 dry soils and 36 of 37 wet soils using fluorescence. The threshold for discrimination can be optimized for classification accuracy for each soil. Fluorescence techniques are less ambiguous than reflectance methods and are better suited for discriminating crop residues on soils. Furthermore, if properly implemented, fluorescence techniques can be used to quantify crop residue cover in the field. C1 NASA,GODDARD SPACE FLIGHT CTR,GREENBELT,MD 20771. UNIV MARYLAND,DEPT GEOG,COLLEGE PK,MD 20742. USA,ENGINEER TOPOG LABS,FT BELVOIR,VA 22060. RP DAUGHTRY, CST (reprint author), USDA ARS,REMOTE SENSING RES LAB,BLDG 007 BARC W,10300 BALTIMORE AVE,BELTSVILLE,MD 20705, USA. RI Irons, James/D-8535-2012 NR 18 TC 38 Z9 40 U1 3 U2 5 PU AMER SOC AGRONOMY PI MADISON PA 677 S SEGOE RD, MADISON, WI 53711 SN 0002-1962 J9 AGRON J JI Agron. J. PD MAR-APR PY 1995 VL 87 IS 2 BP 165 EP 171 PG 7 WC Agronomy SC Agriculture GA QX030 UT WOS:A1995QX03000005 ER PT J AU WINSLOW, TM OSSIPOV, MA FAZIO, GP SIMONSON, JS REDBERG, RF SCHILLER, NB AF WINSLOW, TM OSSIPOV, MA FAZIO, GP SIMONSON, JS REDBERG, RF SCHILLER, NB TI 5-YEAR FOLLOW-UP-STUDY OF THE PREVALENCE AND PROGRESSION OF PULMONARY-HYPERTENSION IN SYSTEMIC LUPUS-ERYTHEMATOSUS SO AMERICAN HEART JOURNAL LA English DT Article ID NONINVASIVE EVALUATION; DISEASE; DOPPLER; MANIFESTATIONS; HEMODYNAMICS; EXERCISE AB The purpose of this study was to determine the prevalence and progression of pulmonary hypertension over a 5-year follow-up period in 28 patients with systemic lupus erythematosus (SLE) who were originally enrolled in an echocardiographic study of pulmonary hypertension in 1985 and 1986. Twenty healthy volunteers without cardiac or pulmonary disease participated as normal controls. Each patient and control underwent a complete Doppler echocardiographic study. Doppler echocardiographic recordings of tricuspid insufficiency, with saline contrast enhancement when necessary, were used to calculate pulmonary artery systolic pressure according to the modified Bernoulli equation. Doppler echocardiographic measurement of cardiac output was performed at rest for each subject, and pulmonary resistance was calculated by dividing the pulmonary artery systolic pressure by the cardiac output. These results were compared to results of the original studies to detect serial changes in pulmonary pressure and pulmonary resistance; results were also compared to the group of normal controls. The prevalence of pulmonary hypertension increased from 14% at the first study to 43% at follow-up. A significant increase in mean systolic pulmonary artery pressure was detected in the SLE patients during the follow-up period: 23.4 vs 27.5 mm Hg (p < 0.005). In addition, a significantly higher pulmonary artery pressure was detected in the SLE patients compared with the normal controls (p < 0.005). An increase in pulmonary resistance during the follow-up period was detected for the SLE group as a whole (p < 0.001) and for the subgroup of patients with pulmonary hypertension at the second study (p < 0.001), implying that the mechanism for pulmonary hypertension was an increase in pulmonary vascular resistance. In conclusion, pulmonary hypertension is common in SLE, is gradually progressive over time, and is related to an increase in pulmonary resistance. C1 UNIV CALIF SAN FRANCISCO,CARDIOVASC RES INST,DIV MED,JOHN HENRY MILLS ECHOCARDIOG LAB,SAN FRANCISCO,CA 94143. TRIPLER ARMY MED CTR,DEPT INTERNAL MED,SERV CARDIOL,HONOLULU,HI 96859. CARDIOVASC CONSULTANTS LTD,MINNEAPOLIS,MN. NR 28 TC 79 Z9 89 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-8703 J9 AM HEART J JI Am. Heart J. PD MAR PY 1995 VL 129 IS 3 BP 510 EP 515 DI 10.1016/0002-8703(95)90278-3 PG 6 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA QK465 UT WOS:A1995QK46500017 PM 7872181 ER PT J AU STOLL, BC ASHCOM, TL JOHNS, JP JOHNSON, JE RUBAL, BJ AF STOLL, BC ASHCOM, TL JOHNS, JP JOHNSON, JE RUBAL, BJ TI EFFECTS OF ATENOLOL ON REST AND EXERCISE HEMODYNAMICS IN PATIENTS WITH MITRAL-STENOSIS SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Article ID SINUS RHYTHM; DOPPLER AB Beta-blocker therapy remains controversial in patients with mitral stenosis. In this randomized, double-blind, crossover, placebo-controlled study, the effects of atenolol (50 and 100 mg/day) were assessed in 15 patients (aged 46 +/- 11 years) with mitral stenosis (mean valve area 1.0 +/- 0.4 cm(2); New York Heart Association class II or III) at rest and during upright bicycle ergometry. Doppler echocardiography was used to compare heart rate, cardiac and stroke volume indexes, diastolic filling period, and peak and mean transmitral gradients; a metabolic cart was used to obtain maximal oxygen consumption, carbon dioxide production, and anaerobic threshold. Beta-blocking therapy did not improve exercise time, external work, maximal oxygen consumption rate, or anaerobic threshold. Compared with placebo, maximal oxygen consumption rate and cardiac index decreased (p <0.05) >11% and >20%, respectively, with atenolol at peak exercise. Although heart rate was reduced >20% and diastolic filling period prolonged >40% by atenolol at rest and exercise (p <0.05), stroke volume index changed little compared with placebo. The data suggest that despite lower trans-valvular pressure gradients, little benefit in exercise performance is achieved with beta-blocker therapy in patients with severe mitral stenosis. RP STOLL, BC (reprint author), BROOKE ARMY MED CTR,DEPT MED,SERV CARDIOL,FT SAM HOUSTON,TX 78234, USA. NR 14 TC 14 Z9 15 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD MAR 1 PY 1995 VL 75 IS 7 BP 482 EP 484 DI 10.1016/S0002-9149(99)80585-2 PG 3 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA QH855 UT WOS:A1995QH85500011 PM 7863993 ER PT J AU UTT, TW MEYERS, CE WIERZBA, TF HONDRUM, SO AF UTT, TW MEYERS, CE WIERZBA, TF HONDRUM, SO TI A 3-DIMENSIONAL COMPARISON OF CONDYLAR POSITION CHANGES BETWEEN CENTRIC RELATION AND CENTRIC OCCLUSION USING THE MANDIBULAR POSITION INDICATOR SO AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS LA English DT Article ID TEMPOROMANDIBULAR-JOINT RADIOGRAPHS; ASYMPTOMATIC POPULATION; DYSFUNCTION; DIAGNOSIS; DISORDERS AB The mandibular position indicator (MPI) was used to compare condylar position between centric relation (CR) and centric occlusion (CO) for 107 patients before orthodontic treatment. The MPI data were examined to determine frequency, direction, and magnitude of CO-CR difference; and data were analyzed for possible correlation to the patient's Angle classification, ANB angular measurement, age, or gender. Only one patient (0.9%) had no measurable CO-CR difference in all three spatial planes. Six subjects (5.6%) showed a shift in condylar position in the transverse plane without a measurable difference in the sagittal plane. Twenty patients (18.7%) experienced a superoinferior (SI) or anteroposterior (AP) condylar displacement of at least 2.0 mm on one or both sides; 17 (15.9%) displayed a transverse shift at the level of the condyles of 0.5 mm or greater. No statistical difference was found between the 31 patients with Class I malocclusions and 72 patients with Class II malocclusions when comparing the amount or direction of CO-CP change. The amount of CO-CR difference was nearly identical for right and left sides with the amount of SI displacement (x = 0.84 mm) consistently greater than AP displacement (x = 0.61 mm). Only weak correlations were found between movements of right and left condyles. The average transverse CO-CR difference was 0.27 mm. Patient age, ANB angle, gender, or Angle classification cannot be used to predict frequency, magnitude, or direction of CO-CR changes at the level of the condyles. C1 HENRY M JACKSON FDN,ROCKVILLE,MD. USA,ORTHODONT RESIDENCY PROGRAM,APO,AE. RP UTT, TW (reprint author), USA,DENT CORPS,INST DENT RES,89TH MED DET,UNIT 30401,BOX 2545,APO,AE 09131, USA. NR 60 TC 31 Z9 40 U1 1 U2 2 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0889-5406 J9 AM J ORTHOD DENTOFAC JI Am. J. Orthod. Dentofac. Orthop. PD MAR PY 1995 VL 107 IS 3 BP 298 EP 308 DI 10.1016/S0889-5406(95)70146-X PG 11 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA QL597 UT WOS:A1995QL59700017 PM 7879763 ER PT J AU REGENNITTER, FJ VOLZ, JE AF REGENNITTER, FJ VOLZ, JE TI AN INTRODUCTION TO THE INTERNET .2. SO AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS LA English DT Editorial Material RP REGENNITTER, FJ (reprint author), USA,DENT CORPS,FT KNOX,KY 40121, USA. NR 26 TC 3 Z9 3 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0889-5406 J9 AM J ORTHOD DENTOFAC JI Am. J. Orthod. Dentofac. Orthop. PD MAR PY 1995 VL 107 IS 3 BP 339 EP 344 DI 10.1016/S0889-5406(95)70150-8 PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA QL597 UT WOS:A1995QL59700025 PM 7879768 ER PT J AU HOLLAND, TD AF HOLLAND, TD TI BRIEF COMMUNICATION - ESTIMATION OF ADULT STATURE FROM THE CALCANEUS AND TALUS SO AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY LA English DT Note DE HAMANN-TODD COLLECTION; TARSALS ID FRAGMENTARY AB Calcanei and tall of 100 skeletons in the Hamann-Todd Collection at the Cleveland Museum of Natural History were measured. The skeletons represented 50 males and 50 females distributed equally by race, i.e., whites and blacks. Linear-regression equations, with standard errors ranging from 4.09 to 6.11 cm, were derived from these measurements for the purpose of estimating stature. Two independent control samples, including one comprised of remains of American servicemen lost in World War II and the Korea and Vietnam wars, were tested with relatively accurate results. (C) 1995 Wiley-Liss, Inc. RP HOLLAND, TD (reprint author), USA,CENT IDENTIFICAT LAB,HICKAM AFB,HI 96853, USA. NR 19 TC 47 Z9 52 U1 2 U2 7 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0002-9483 J9 AM J PHYS ANTHROPOL JI Am. J. Phys. Anthropol. PD MAR PY 1995 VL 96 IS 3 BP 315 EP 320 DI 10.1002/ajpa.1330960308 PG 6 WC Anthropology; Evolutionary Biology SC Anthropology; Evolutionary Biology GA QP638 UT WOS:A1995QP63800007 PM 7785728 ER PT J AU SARIBANSOHRABY, S MIES, F ABRAMOW, M FISHER, RS AF SARIBANSOHRABY, S MIES, F ABRAMOW, M FISHER, RS TI ALDOSTERONE STIMULATION OF GTP HYDROLYSIS IN MEMBRANES FROM RENAL EPITHELIA SO AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY LA English DT Article DE GUANOSINETRIPHOSPHATASE; A6 CELLS; SODIUM TRANSPORT; PERTUSSIS TOXIN; APICAL MEMBRANE ID NA+ CHANNEL; ADENYLATE-CYCLASE; APICAL MEMBRANE; A6 CELLS; SODIUM-TRANSPORT; PROTEIN; ACTIVATION; AMILORIDE; MECHANISM; TOXIN AB Specific hydrolysis of GTP catalyzed by membranes prepared from A6 epithelial cells grown on porous supports was measured. Aldosterone treatment of the cells for 4 h increased Na+ transport and stimulated GTP hydrolysis by apical membranes in vitro more than twofold over basal levels. This stimulation was attributed to an increase in maximum velocity with little change in Michaelis-Menten constant values. Na+ transport rate and GTP hydrolysis were linearly correlated after aldosterone. This relationship was maintained when aldosterone's response was blunted by various inhibitors. Spironolactone decreased both the hormone-stimulated guanosinetriphosphatase (GTPase) and the Nat transport rate. Pertussis toxin, which exerted minimal effects on basal rates, reduced the increase of Nat current normally observed after aldosterone and the hormone stimulation of GTPase activity. The expression of classical G(i)/G(o)-type G proteins was not increased after hormone treatment. When A6 cells were grown on nonporous plastic dishes, aldosterone neither stimulated GTPase activity nor increased amiloride-blockable Na-22(+) fluxes. We propose that activation of one or more G proteins in the apical membrane of AG cells is directly involved in the natriferic action of aldosterone. C1 WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, DEPT NEPHROL, WASHINGTON, DC 20307 USA. RP SARIBANSOHRABY, S (reprint author), FREE UNIV BRUSSELS, PHYTOPATHOL LAB, BAT E 2 4, 808 ROUTE LENNIK, B-1070 BRUSSELS, BELGIUM. NR 37 TC 15 Z9 15 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0363-6143 J9 AM J PHYSIOL-CELL PH JI Am. J. Physiol.-Cell Physiol. PD MAR PY 1995 VL 268 IS 3 BP C557 EP C562 PG 6 WC Cell Biology; Physiology SC Cell Biology; Physiology GA QM032 UT WOS:A1995QM03200005 PM 7900764 ER PT J AU SCIUTO, AM STRICKLAND, PT KENNEDY, TP GURTNER, GH AF SCIUTO, AM STRICKLAND, PT KENNEDY, TP GURTNER, GH TI PROTECTIVE EFFECTS OF N-ACETYLCYSTEINE TREATMENT AFTER PHOSGENE EXPOSURE IN RABBITS SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Article ID LUNG TOXICITY; INJURY; GLUTATHIONE; MEDIATORS AB We examined the effects of treatment with N-acetylcysteine (NAG) on pulmonary edema formation in isolated perfused rabbit lungs following in vivo phosgene exposure. This study focused on posttreatment intratracheal administration of NAC after exposure. Rabbits, 2 to 3 kg, were exposed to a cumulative dose of phosgene to attain a concentration x time exposure effect of 1,500 ppm/min. Lungs were perfused with Krebs-Henseleit buffer at 40 ml/min from 70 to 150 min after exposure. Pulmonary artery pressure (Ppa), tracheal pressure (Pt), and the rate of lung weight gain (LWG) were measured continuously. Perfusate concentration of peptide leukotrienes LTC(4), D-4, and E(4) were measured every 20 min during perfusion. At the conclusion of the experiment, lung tissue was analyzed for reduced and oxidized glutathione (GSH and GSSG) and lipid peroxidation (thiobarbituric acid-reactive substances, TEARS). Exposure to phosgene significantly increased Pt, LWG, LTC(4), D-4, and E(4), TEARS, and GSSG over time compared with controls. Compared with phosgene, intratracheal NAC lowered Ppa, LWG, LTC(4), D-4, and E(4), TEARS, and GSSG. We conclude that NAC protected against phosgene-induced lung injury by acting as an antioxidant by maintaining protective levels of glutathione, reducing both lipid peroxidation and production of arachidonic acid metabolites. C1 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT ENVIRONM HLTH SCI,BALTIMORE,MD. USA,MED RES INST CHEM DEF,DIV PATHOPHYSIOL,PHYSIOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. NEW YORK MED COLL,DEPT MED,VALHALLA,NY 10595. NEW YORK MED COLL,DEPT PHYSIOL,VALHALLA,NY 10595. FU NHLBI NIH HHS [HL-83543] NR 30 TC 59 Z9 62 U1 1 U2 1 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 1073-449X J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PD MAR PY 1995 VL 151 IS 3 BP 768 EP 772 PG 5 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA QL391 UT WOS:A1995QL39100031 PM 7881668 ER PT J AU SHANLEY, DJ AF SHANLEY, DJ TI TUBERCULOSIS OF THE SPINE - IMAGING FEATURES SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article ID COMPUTED-TOMOGRAPHY; INFECTIONS AB Spinal tuberculosis, the most common form of skeletal involvement, is increasing in prevalence because of the resurgence of tuberculosis during the past decade in patients with AIDS, the spread of tuberculosis among the homeless, and the expanding immigrant population. Spinal infection is usually the result of hematogenous seeding of the vertebral body, and the diagnosis often remains elusive because of the indolent nature of tuberculous infection, As a result, the radiographic findings and the signs and symptoms are typically far advanced when the diagnosis is finally established. Radiographic manifestations of tuberculous spondylitis include intraosseous and paraspinal abscess formation, subligamentous spread of infection, vertebral body destruction and collapse, and extension into the spinal epidural space. Significant instability and deformity of the spine can result, mandating prompt diagnosis and treatment to prevent permanent neurologic damage. The purpose of this essay is to illustrate the broad spectrum of imaging findings on plain radiographs, bone scans, CT scans, myelograms, and MR images of patients with spinal tuberculosis. The value of MR imaging in determining the extent of disease is demonstrated. RP SHANLEY, DJ (reprint author), TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859, USA. NR 8 TC 84 Z9 87 U1 0 U2 4 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD MAR PY 1995 VL 164 IS 3 BP 659 EP 664 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA QH860 UT WOS:A1995QH86000022 PM 7863889 ER PT J AU EGERLAND, WO AF EGERLAND, WO TI COMPLEX ROOTS OF SPECIAL QUARTIC POLYNOMIALS SO AMERICAN MATHEMATICAL MONTHLY LA English DT Letter RP EGERLAND, WO (reprint author), ARL,ABERDEEN PROVING GROUND,MD, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MATHEMATICAL ASSOC AMER PI WASHINGTON PA 1529 18TH STREET NW, WASHINGTON, DC 20036 SN 0002-9890 J9 AM MATH MON JI Am. Math. Mon. PD MAR PY 1995 VL 102 IS 3 BP 277 EP 277 PG 1 WC Mathematics SC Mathematics GA QL294 UT WOS:A1995QL29400019 ER PT J AU MULLIGAN, C HOWELL, C HATLEY, R MARTINDALE, R CLARK, J AF MULLIGAN, C HOWELL, C HATLEY, R MARTINDALE, R CLARK, J TI CONSERVATIVE MANAGEMENT OF PEDIATRIC PANCREATIC PSEUDOCYST USING OCTREOTIDE ACETATE SO AMERICAN SURGEON LA English DT Article; Proceedings Paper CT 62nd Annual Scientific Meeting of the Southeastern Surgical Conference CY FEB 06-10, 1994 CL LAKE BUENA VISTA, FL ID PERSISTENT HYPERINSULINEMIC HYPOGLYCEMIA; ACTING SOMATOSTATIN ANALOG; LONG-TERM TREATMENT; PERCUTANEOUS DRAINAGE; CATHETER DRAINAGE; CHILDREN; SANDOSTATIN; INFANCY AB Pancreatic pseudocysts in children are rare. A total of 213 cases have been reported in the literature, the majority secondary to trauma (65%). Treatment options range from conservative, non-operative management to operative drainage. Octreotide acetate, a long-acting analog of somatostatin, is a synthetic peptide with a variety of endocrine and gastrointestinal functions. Octreotide has been successfully used following pancreatic surgery to reduce exocrine function and most recently in the management of adult pancreatic pseudocysts. We report the efficacy of octreotide, as an adjunct to treatment, in two children with pancreatic pseudocyst. Each child was treated conservatively with bowel rest, hyperalimentation, and octreotide acetate (2.5 mug/kg SQ QD). Complete resolution of the pseudocysts occurred within 5 weeks. We conclude that octreotide acetate is a safe and potentially effective adjunct in the treatment of pediatric pancreatic pseudocyst, and should be added to the management of pseudocyst before drainage procedures. C1 MED COLL GEORGIA,DEPT SURG,AUGUSTA,GA 30912. RP MULLIGAN, C (reprint author), EISENHOWER ARMY MED CTR,DEPT GEN SURG,FT GORDON,GA 30905, USA. NR 28 TC 12 Z9 14 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI ATLANTA PA 1776 PEACHTREE RD, NW., SUITE 410N, ATLANTA, GA 30309-2352 SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD MAR PY 1995 VL 61 IS 3 BP 206 EP 209 PG 4 WC Surgery SC Surgery GA QM985 UT WOS:A1995QM98500005 PM 7887530 ER PT J AU VELANOVICH, V AF VELANOVICH, V TI FINE-NEEDLE ASPIRATION CYTOLOGY IN THE DIAGNOSIS AND MANAGEMENT OF ECTOPIC BREAST-TISSUE SO AMERICAN SURGEON LA English DT Article; Proceedings Paper CT 62nd Annual Scientific Meeting of the Southeastern Surgical Conference CY FEB 06-10, 1994 CL LAKE BUENA VISTA, FL AB Ectopic breast tissue presents as solitary or multiple masses in young women along the milk line. The most common site is in the axilla. This may present a diagnostic problem as lymphadenopathy, either primary or secondary, or other soft tissue tumors that may present in a similar way. Six patients with eight axillary masses suspicious for ectopic breast tissue were evaluated with fine needle aspiration (FNA) cytology. Five aspirates revealed epithelial cells consistent with breast tissue; one showed adipose tissue; and two were non-diagnostic. This information helped prevent surgery in one pregnant and one lactating woman. Therefore, FNA examination is helpful in the diagnosis of management of ectopic breast tissue. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. RP VELANOVICH, V (reprint author), USA,IRELAND COMMUNITY HOSP,GEN SURG SERV,851 IRELAND LOOP,FT KNOX,KY 40121, USA. NR 4 TC 11 Z9 11 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI ATLANTA PA 1776 PEACHTREE RD, NW., SUITE 410N, ATLANTA, GA 30309-2352 SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD MAR PY 1995 VL 61 IS 3 BP 277 EP 278 PG 2 WC Surgery SC Surgery GA QM985 UT WOS:A1995QM98500021 PM 7887546 ER PT J AU GREILICH, PE CARR, ME CARR, SL CHANG, AS AF GREILICH, PE CARR, ME CARR, SL CHANG, AS TI REDUCTIONS IN PLATELET FORCE DEVELOPMENT BY CARDIOPULMONARY BYPASS ARE ASSOCIATED WITH HEMORRHAGE SO ANESTHESIA AND ANALGESIA LA English DT Article ID CLOT RETRACTION; BLEEDING-TIME; HEPARIN; RECEPTORS; COAGULATION; INHIBITION; SURGERY; THERAPY; RELEASE; ASPIRIN AB Quantitative assessment of platelet dysfunction after cardiopulmonary bypass (CPB) and prediction of excessive microvascular bleeding remain elusive goals. We used a sensitive instrument capable of simultaneously measuring the force generated by platelets during plasma clot retraction and global clot strength. We hypothesized that CPB would significantly reduce these two variables. Platelet-rich plasma was obtained from eight patients undergoing aortocoronary revascularization prior to induction, after 90 min of CPB, and after protamine administration. Platelet force development was measured using a standardized technique that controlled for platelet number and permitted clot formation in the presence of heparin. Despite the presence of a measurable elastic modulus, platelet force development during bypass was abolished. Peak platelet force development after CPB was significantly lower than before CPB (5255 +/- 955 dynes vs 11,600 +/- 780 dynes, P = 0.01). The percent recovery (after/before bypass) of peak platelet force development inversely correlated with tube thoracostomy drainage during the first 24 h after placement (r(s) = -0.71, P = 0.048). This study demonstrates that CPB has dramatic effects on platelet force development. The correlation between the percent recovery of peak platelet force development and blood loss supports the clinical relevance of this measurement. C1 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT ANESTHESIOL,RICHMOND,VA 23298. VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT MED,RICHMOND,VA 23298. VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PATHOL,RICHMOND,VA 23298. MCGUIRE DEPT VET AFFAIRS MED CTR,COAGULAT SPECIAL STUDIES LAB,RICHMOND,VA. RP GREILICH, PE (reprint author), WALTER REED ARMY MED CTR,DEPT CLIN INVEST,6900 GEORGIA AVE NW,WASHINGTON,DC 20307, USA. NR 41 TC 40 Z9 41 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD MAR PY 1995 VL 80 IS 3 BP 459 EP 465 DI 10.1097/00000539-199503000-00005 PG 7 WC Anesthesiology SC Anesthesiology GA QJ611 UT WOS:A1995QJ61100005 PM 7864408 ER PT J AU BYRD, JC HERTLER, AA WEISS, RB FREIMAN, J KWEDER, SL DIEHL, LF AF BYRD, JC HERTLER, AA WEISS, RB FREIMAN, J KWEDER, SL DIEHL, LF TI FATAL RECURRENCE OF AUTOIMMUNE HEMOLYTIC-ANEMIA FOLLOWING PENTOSTATIN THERAPY IN A PATIENT WITH A HISTORY OF FLUDARABINE-ASSOCIATED HEMOLYTIC-ANEMIA SO ANNALS OF ONCOLOGY LA English DT Note DE AUTOIMMUNE HEMOLYTIC ANEMIA; FLUDARABINE; PENTOSTATIN; CHRONIC LYMPHOCYTIC LEUKEMIA; ADVERSE DRUG REACTION ID CHRONIC LYMPHOCYTIC-LEUKEMIA; DEOXYCOFORMYCIN C1 UNIFORMED SERV UNIV HLTH SCI,WASHINGTON,DC. PS,DEPT HEMATOL ONCOL,ROCKWOOD CLIN,SPOKANE,WA. US FDA,CTR DRUG EVALUAT & RES,EPIDEMIOL BRANCH,ROCKVILLE,MD 20857. RP BYRD, JC (reprint author), WALTER REED ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,WASHINGTON,DC 20307, USA. NR 13 TC 29 Z9 29 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0923-7534 J9 ANN ONCOL JI Ann. Oncol. PD MAR PY 1995 VL 6 IS 3 BP 300 EP 301 PG 2 WC Oncology SC Oncology GA QX057 UT WOS:A1995QX05700019 PM 7612497 ER PT J AU JORGENSON, DS ANTOINE, GA AF JORGENSON, DS ANTOINE, GA TI ADVANCES IN THE TREATMENT OF LOWER-EXTREMITY WOUNDS APPLIED TO MILITARY CASUALTIES SO ANNALS OF PLASTIC SURGERY LA English DT Article ID MANAGEMENT; RECONSTRUCTION; FRACTURES; INJURIES; DEFECTS; TRAUMA AB A review of six patients with severe lower extremity injuries (four of six with grade IIIB tibia fractures), resulting from combat in Somalia, was undertaken to identify patterns of injury, treatment, and problems unique to combat injuries. An AK-47 gunshot was the mechanism of injury in five of six patients. Muscle flaps were required in all patients (four pedicled muscle flaps and three free vascularized flaps), with five of six patients undergoing flap closure during the subacute phase. Ilizarov devices were used in three of four grade IIIB tibia fractures. Five major nerve injuries were identified in three of six patients. The ballistic effect of an AK-47 to the soft tissues of the extremity is not a high-energy wound as seen in civilian blunt trauma. Knowledge of ballistics and the delay in definitive flap coverage secondary to evacuation allowed definition of zones of injury and successful use of local flaps in the majority of our patients. The high number of nerve injuries not commonly described with blunt trauma may prevent full rehabilitation. RP JORGENSON, DS (reprint author), WALTER REED ARMY MED CTR,PLAST SURG SERV,WASHINGTON,DC 20307, USA. NR 16 TC 13 Z9 13 U1 1 U2 3 PU LITTLE BROWN CO PI BOSTON PA 34 BEACON STREET, BOSTON, MA 02108-1493 SN 0148-7043 J9 ANN PLAS SURG JI Ann. Plast. Surg. PD MAR PY 1995 VL 34 IS 3 BP 298 EP 303 DI 10.1097/00000637-199503000-00013 PG 6 WC Surgery SC Surgery GA QM271 UT WOS:A1995QM27100013 PM 7598388 ER PT J AU KOMMAREDDI, NS TATA, M KARAYIGITOGLU, C JOHN, VT MCPHERSON, GL HERMAN, MF OCONNOR, CJ LEE, YS AKKARA, JA KAPLAN, DL AF KOMMAREDDI, NS TATA, M KARAYIGITOGLU, C JOHN, VT MCPHERSON, GL HERMAN, MF OCONNOR, CJ LEE, YS AKKARA, JA KAPLAN, DL TI ENZYMATIC POLYMERIZATIONS USING SURFACTANT MICROSTRUCTURES AND THE PREPARATION OF POLYMER-FERRITE COMPOSITES SO APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY LA English DT Article; Proceedings Paper CT 16th Symposium on Biotechnology for Fuels and Chemicals CY MAY 09-13, 1994 CL GATLINBURG, TN SP US DOE, BIOFUELS SYST DIV, ADV IND CONCEPTS DIV, OAK RIDGE NATL LAB, NATL RENEWABLE ENERGY LAB, IDAHO NATL ENG LAB, AMOCO CORP, ARCHER DANIELS MIDLAND CO, BIO TECH RESOURCES L P, DORR OLIVER INC, ENZYME BIO SYST LTD, GENENCOR INT, GIST BROCADES, GOLDEN TECHNOL CO LNC, GRAIN PROC CORP, MARTIN MARIETTA ENERGY SYST INC, MICHIGAN BIOTECHNOL INST, NEW ENERGY CO INDIANA L P, PROC SYST INC, RAPHAEL KATZEN ASSOC INT INC, ROQUETTE AMER INC, SOLVAY ENZYMES INC, A E STALEY, WEYERHAEUSER, AMER CHEM SOC, DIV BIOCHEM TECHNOL DE HORSERADISH PEROXIDASE; MICROEMULSIONS; POLYMERS; NANOPARTICLES AB Horseradish peroxidase has been used as a biocatalyst to synthesize a polymeric material from alkyl-substituted phenols. The synthesis is carried out in a surfactant-based microemulsion environment, with the monomer partitioned at the oil/water interface. The spherical nature of the microemulsion nanodroplets may be acting as a template for the polymer synthesis. The resultant polymer particles are spherical and typically in the submicron size range. The characteristics of the morphology development are described. The templating effect of the surfactant environment becomes more evident when the polymer particles are fully dissolved in a suitable solvent and refolded in the presence of surfactant. Interestingly, submicron-sized spherical particles are obtained only in the presence of surfactant, and particles of arbitrary morphology are seen in the absence of surfactant. Aspects of morphology development leading to the preparation of polymer-iron oxide composites are described. C1 TULANE UNIV,DEPT CHEM ENGN,NEW ORLEANS,LA 70118. TULANE UNIV,DEPT CHEM,NEW ORLEANS,LA 70118. UNIV NEW ORLEANS,DEPT CHEM,NEW ORLEANS,LA 70148. USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. RI John, Vijay/G-3747-2010 NR 6 TC 9 Z9 9 U1 0 U2 3 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07012 SN 0273-2289 J9 APPL BIOCHEM BIOTECH JI Appl. Biochem. Biotechnol. PD SPR PY 1995 VL 51-2 BP 241 EP 252 DI 10.1007/BF02933427 PG 12 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA QW150 UT WOS:A1995QW15000023 ER PT J AU XU, XD JOHN, VT MCPHERSON, GL GRIMM, DA AKKARA, JA KAPLAN, DT AF XU, XD JOHN, VT MCPHERSON, GL GRIMM, DA AKKARA, JA KAPLAN, DT TI A COMBINED CHEMICAL-ENZYMATIC METHOD TO REMOVE SELECTED AROMATICS FROM AQUEOUS STREAMS SO APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY LA English DT Article; Proceedings Paper CT 16th Symposium on Biotechnology for Fuels and Chemicals CY MAY 09-13, 1994 CL GATLINBURG, TN SP US DOE, BIOFUELS SYST DIV, ADV IND CONCEPTS DIV, OAK RIDGE NATL LAB, NATL RENEWABLE ENERGY LAB, IDAHO NATL ENG LAB, AMOCO CORP, ARCHER DANIELS MIDLAND CO, BIO TECH RESOURCES L P, DORR OLIVER INC, ENZYME BIO SYST LTD, GENENCOR INT, GIST BROCADES, GOLDEN TECHNOL CO LNC, GRAIN PROC CORP, MARTIN MARIETTA ENERGY SYST INC, MICHIGAN BIOTECHNOL INST, NEW ENERGY CO INDIANA L P, PROC SYST INC, RAPHAEL KATZEN ASSOC INT INC, ROQUETTE AMER INC, SOLVAY ENZYMES INC, A E STALEY, WEYERHAEUSER, AMER CHEM SOC, DIV BIOCHEM TECHNOL DE AROMATICS; AQUEOUS STREAMS; PHENOLICS; FENTON REACTION; ENZYMATIC POLYMERIZATION ID FENTONS REAGENT; PEROXIDASE; WATER AB Aromatics are major pollutants found in aqueous environments and in sediments. Although there are many chemical and biochemical processes to remove and/or treat these contaminants, they have to be considered in light of the economcs and the time scales for treatment. We describe our initial work on a hybrid chemical-enzymatic technique to remove aromatics from aqueous streams. The aromatic is first converted to the corresponding phenol through classical Fenton-type chemistry involving catalysis by Fe(II). The phenol is subsequently polymerized through an enzymatic mechanism, using horseradish peroxidase as the oxidative enzyme. The polymer is insoluble in water and can be easily recovered. In addition, such phenolic polymers are useful products with varied applications in coatings and resins technologies. Thus, the pollutants can be eventually converted to useful products. C1 TULANE UNIV,DEPT CHEM ENGN,NEW ORLEANS,LA 70118. TULANE UNIV,DEPT CHEM,NEW ORLEANS,LA 70118. TULANE UNIV,COORDINATED INSTRUMENTAT FACIL,NEW ORLEANS,LA 70118. USA,NATICK RES DEV & ENGN LABS,NATICK,MA 01760. RI John, Vijay/G-3747-2010 NR 12 TC 3 Z9 3 U1 0 U2 2 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07012 SN 0273-2289 J9 APPL BIOCHEM BIOTECH JI Appl. Biochem. Biotechnol. PD SPR PY 1995 VL 51-2 BP 649 EP 660 DI 10.1007/BF02933466 PG 12 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA QW150 UT WOS:A1995QW15000062 ER PT J AU WALSH, DS DUNN, CL KONZELMAN, J SAU, P JAMES, WD AF WALSH, DS DUNN, CL KONZELMAN, J SAU, P JAMES, WD TI A VAGINAL PROSTHETIC DEVICE AS AN AID IN TREATING ULCERATIVE LICHEN-PLANUS OF THE MUCOUS-MEMBRANE - SUCCESSFUL COMBINATION THERAPY WITH A CORTICOSTEROID-BIOADHESIVE COMPOUND AND IONTOPHORESIS SO ARCHIVES OF DERMATOLOGY LA English DT Note ID FOLLOW-UP C1 HENRY M JACKSON FDN,ROCKVILLE,MD. RP WALSH, DS (reprint author), WALTER REED ARMY MED CTR,DEPT DERMATOL,WASHINGTON,DC 20307, USA. NR 15 TC 12 Z9 12 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD MAR PY 1995 VL 131 IS 3 BP 265 EP 267 DI 10.1001/archderm.131.3.265 PG 3 WC Dermatology SC Dermatology GA QM006 UT WOS:A1995QM00600002 PM 7887654 ER PT J AU CUOZZO, DW AARONSON, B BENSON, PM SAU, P AF CUOZZO, DW AARONSON, B BENSON, PM SAU, P TI CANDIDA-KRUSEI ABDOMINAL-WALL ABSCESS PRESENTING AS ECCHYMOSIS - DIAGNOSIS WITH ULTRASOUND SO ARCHIVES OF DERMATOLOGY LA English DT Note ID RECTUS SHEATH HEMATOMA; ANTICOAGULANT-THERAPY; HEPARIN NECROSIS C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 14 TC 1 Z9 2 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD MAR PY 1995 VL 131 IS 3 BP 275 EP 277 PG 3 WC Dermatology SC Dermatology GA QM006 UT WOS:A1995QM00600003 PM 7887655 ER PT J AU YOUNG, TD AF YOUNG, TD TI CAPABILITIES-BASED DEFENSE PLANNING - THE AUSTRALIAN EXPERIENCE SO ARMED FORCES & SOCIETY LA English DT Article AB Prior to the end of the Cold War, most militaries of the Western Alliance planned their force structures primarily on the basis of an identifiable and quantifiable threat. The force planning process, for most participants, was relatively predictable and comfortable. However, since the end of the Cold War, the lack of such threats has resulted in a scramble to create new approaches by most members of NATO for developing and justifying force structures. This issue, of creating well-reasoned force development plans for political authorities, is not an inconsequential matter, particularly because many NATO countries have rushed to effect substantial defense savings.(1) Defense and Alliance officials now face the difficult problem of translating the implications of a threat-ambiguous strategic environment into defense planning and force development methodologies that are applicable to modern military structures and convincing to cost-conscious politicians.(2) Although this is not widely understood in NATO, Australia has not designed its force structure on the basis of an identifiable and quantifiable threat since the late 1960s.(3) By the end of the 1980s, after many false starts, the Australian Department of Defence, including the Headquarters Australian Defence Force (HQADF), had developed principles and processes for guiding force development that reflect government strategy and guidance to defend that country, while making threats less weighty. In their place, ''credible contingencies'' that are based on capabilities rather than on existing threat, as defined and described below, are employed. The result of these efforts has been to create a unique methodology that makes the development of the Australian Defence Force (ADF) more relevant to Australia's enduring strategic circumstances. At the same time, the ADF has become more responsive to government guidance and less influenced by parochial interests and problematical threat scenarios. Thus the relevance of assessing the Australian experience is that it establishes guidelines against which the ADF could conceivably operate in a nonthreat specific environment, while making adequate provision for other important factors such as financial limitations. Notwithstanding the unique characteristics of Australia's geostrategic situation, the requirement that Australian defense planners come to terms with a threat-ambiguous environment is broadly similar to the imperative now faced by many Western countries in the post-Cold War era. The purpose of this article is to describe the Australian defense planning process and its force development methodology, concluding with an analysis of the lessons to be learned from Australia in implementing such a system. While not all aspects of the process are germane elsewhere, the 20-year experience of the Australian Department of Defence and the ADF planners warrants careful examination. At the least, defense planners elsewhere may avoid mistakes that have been made by their Australian counterparts. A summary of Australia's planning performance suggests that its methodology may actually provide significantly more positive benefits. Australian defense expenditures, as a percentage of Gross Domestic Product (GDP), have remained essentially constant since the 1970s and are currently about $10 billion per annum (Australian). However, since the 1970s (without increasing the defense-to-GDP ratio), the ADF has become an increasingly joint force, capable of executing additional national tasks. It has also retained an ability to participate in allied operations without employing a threat-based planning process. While perhaps not perfect, aspects of this system should warrant serious consideration by others. (Figure 1.) RP YOUNG, TD (reprint author), USA,WAR COLL,INST STRATEG STUDIES,CARLISLE,PA 17013, USA. NR 25 TC 0 Z9 0 U1 0 U2 1 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD SPR PY 1995 VL 21 IS 3 BP 349 EP & DI 10.1177/0095327X9502100303 PG 0 WC Political Science; Sociology SC Government & Law; Sociology GA QY410 UT WOS:A1995QY41000002 ER PT J AU CANNON, M AF CANNON, M TI COMMANDERS IN CHIEF - PRESIDENTIAL LEADERSHIP IN MODERN WARS - DAWSON,JG SO ARMED FORCES & SOCIETY LA English DT Book Review RP CANNON, M (reprint author), US MIL ACAD,DEPT HIST,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD SPR PY 1995 VL 21 IS 3 BP 472 EP 473 DI 10.1177/0095327X9502100310 PG 2 WC Political Science; Sociology SC Government & Law; Sociology GA QY410 UT WOS:A1995QY41000009 ER PT J AU KAMIMORI, GH HOYT, RW EDDINGTON, ND YOUNG, PM DURKOT, MJ FORTE, VA BRUNHART, AE LUGO, S CYMERMAN, A AF KAMIMORI, GH HOYT, RW EDDINGTON, ND YOUNG, PM DURKOT, MJ FORTE, VA BRUNHART, AE LUGO, S CYMERMAN, A TI EFFECTS OF CHRONIC HYPOXIA ON THE PHARMACOKINETICS OF CAFFEINE AND CARDIO-GREEN IN MICRO SWINE SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID HEPATIC BLOOD-FLOW; INDOCYANINE GREEN; DISPOSITION; EXERCISE; HUMANS AB Methods: The pharmacokinetics of caffeine and cardio-green (ICG) were examined in four micro swine at sea level (SEA) and following 21 d continuous exposure to 4600 m (ALT) in a hypobaric chamber, Caffeine (84.7 mg) and ICG(IO mg) were administered as separate intravenous boluses and sequential blood samples collected, Results: Caffeine clearance significantly (p < 0.05) increased in ALT (96.8 +/- 20.0 ml min(-1)) as compared to SEA (53.6 a 24.8 ml min(-1)), demonstrating that liver function increased in ALT, There was no significant change in the ratio of primary metabolites to caffeine, suggesting that the increase in clearance was not due to a change in the rate of caffeine metabolism. ICG clearance significantly increased in ALT (179.8 a 57.4 ml min(-1)) as compared to SEA (84.4 +/- 28.9 ml min(-1)) indicating that hepatic blood flow (HBF) increased. Conclusion: These results demonstrate that chronic exposure to 4600 m increases the clearance of caffeine and ICG in the micro swine model and suggests that the increase in caffeine clearance is related to HBF. C1 UNIV MARYLAND,DEPT PHARMACEUT,PHARMACOKINET BIOPHARMACEUT LAB,BALTIMORE,MD. USA,ENVIRONM MED RES INST,NATICK,MA 01760. RP KAMIMORI, GH (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BEHAV BIOL,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307, USA. NR 26 TC 4 Z9 4 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAR PY 1995 VL 66 IS 3 BP 247 EP 250 PG 4 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA QK391 UT WOS:A1995QK39100009 PM 7661835 ER PT J AU LARUSSA, VF INNIS, BL AF LARUSSA, VF INNIS, BL TI MECHANISMS OF DENGUE VIRUS-INDUCED BONE-MARROW SUPPRESSION SO BAILLIERES CLINICAL HAEMATOLOGY LA English DT Article ID TUMOR-NECROSIS-FACTOR; ERYTHROID COLONY FORMATION; THYMIC REGULATORY CELLS; INTERFERON-ALPHA; HEMORRHAGIC-FEVER; FACTOR-RECEPTOR; GROWTH-FACTOR; CULTURES; BIOLOGY; INVITRO C1 WALTER REED ARMY INST RES,DEPT VIRUS RES,WASHINGTON,DC 20307. RP LARUSSA, VF (reprint author), WALTER REED ARMY INST RES,DEPT HEMATOL & VASC BIOL,HEMATOPOIESIS & BONE MARROW CELL BIOL SECT,WASHINGTON,DC 20307, USA. NR 64 TC 73 Z9 78 U1 1 U2 4 PU BAILLIERE TINDALL PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0950-3536 J9 BAILLIERE CLIN HAEM JI Baillieres Clin. Haematol. PD MAR PY 1995 VL 8 IS 1 BP 249 EP 270 DI 10.1016/S0950-3536(05)80240-9 PG 22 WC Hematology SC Hematology GA QW108 UT WOS:A1995QW10800012 PM 7663049 ER PT J AU HOSKIN, FCG WALKER, JE DETTBARN, WD WILD, JR AF HOSKIN, FCG WALKER, JE DETTBARN, WD WILD, JR TI HYDROLYSIS OF TETRISO BY AN ENZYME DERIVED FROM PSEUDOMONAS-DIMINUTA AS A MODEL FOR THE DETOXICATION OF O-ETHYL S-(2-DIISOPROPYLAMINOETHYL) METHYLPHOSPHONOTHIOLATE(VX) SO BIOCHEMICAL PHARMACOLOGY LA English DT Article DE ACETYLCHOLINESTERASE; DETOXICATION; ORGANOPHOSPHORUS HYDROLASE (OPH); PSEUDOMONAS DIMINUTA; TETRISO; VX ID PHOSPHOTRIESTERASE AB An enzyme termed organophosphorus hydrolase (OPH), derived from Pseudomonas diminuta, had been found previously to hydrolyze the powerful acetylcholinesterase (AChE) inhibitor O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothiolate (VX). This enzyme has now been shown to be correlated with the loss of AChE inhibitory potency (detoxication). OPH also hydrolyzed and detoxified the VX analogue, O,O-diisopropyl S-(2-diisopropylaminoethyl) phosphorothiolate (Tetriso), also a potent AChE inhibitor, about five times faster than VX. The K-m for the hydrolysis of the P-S bond of Tetriso was 6.7 x 10-(3) M. OPH also hydrolyzed diisopropylphosphorofluoridate (DFP) 50-60 times faster than Tetriso, and 1,2,2-trimethylpropyl methylphosphonofluoridate (Soman) about seven times faster than Tetriso. DFP was a non-competitive inhibitor of Tetriso hydrolysis, K-i = 8.7 x 10(-4) M. The DFP hydrolysis product, diisopropyl phosphate, was a competitive inhibitor, K-i = 2.3 x 10(-4) M. The rate of detoxication of Tetriso compared with the rate of hydrolysis suggests that OPH may not be totally specific for PS bond cleavage. OPH was inhibited completely by 1.5 x 10(-4) M 8-hydroxyquinoline-5-sulfonate or 1,10-phenanthroline, both transition element chelators, but inhibited only partially by EDTA, a much more potent chelator. C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. VANDERBILT UNIV,SCH MED,DEPT PHARMACOL,NASHVILLE,TN 37212. TEXAS A&M UNIV,DEPT BIOCHEM & BIOPHYS,COLLEGE STN,TX 77843. RP HOSKIN, FCG (reprint author), MARINE BIOL LAB,WOODS HOLE,MA 02543, USA. NR 19 TC 42 Z9 44 U1 0 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0006-2952 J9 BIOCHEM PHARMACOL JI Biochem. Pharmacol. PD MAR 1 PY 1995 VL 49 IS 5 BP 711 EP 715 DI 10.1016/0006-2952(94)00496-9 PG 5 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA QM055 UT WOS:A1995QM05500016 PM 7887986 ER PT J AU SUMFEST, JM BURNS, MW MITCHELL, ME AF SUMFEST, JM BURNS, MW MITCHELL, ME TI PSEUDOURETEROCELE - POTENTIAL FOR MISDIAGNOSIS OF AN ECTOPIC URETER AS A URETEROCELE SO BRITISH JOURNAL OF UROLOGY LA English DT Article DE URETEROCELE; URETER; ECTOPIC; UROLOGICAL DISEASES ID CHILDREN AB Objective To present several case reports of children with 'pseudoureteroceles'. Familiarization with this entity should help to avoid an error in diagnosis and possible improper therapy. Patients and methods Three girls with ectopic ureters entering mesonephric duct cysts are presented for review. Results Misdiagnosis of the pseudoureterocele as an ectopic ureter was made in two children, The 'pseudoureterocele' may lie dormant for many years and often presents with acute urinary incontinence and/or onset of urinary tract infections. Resection of the dysplastic kidney and ipsilateral ureter, marsupialization of the cyst into the vagina, and closure of the vesical fistula is the preferred treatment. Conclusion An ectopic ureter draining into a Gartner's duct cyst can be confused with an ectopic ureterocele, Correct diagnosis is vital to ensure proper treatment. C1 CHILDRENS HOSP & MED CTR,DEPT UROL,SEATTLE,WA 98105. RP SUMFEST, JM (reprint author), TRIPLER ARMY MED CTR,DIV PEDIAT UROL,HONOLULU,HI 96859, USA. NR 14 TC 11 Z9 12 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0007-1331 J9 BRIT J UROL JI Br. J. Urol. PD MAR PY 1995 VL 75 IS 3 BP 401 EP 405 DI 10.1111/j.1464-410X.1995.tb07357.x PG 5 WC Urology & Nephrology SC Urology & Nephrology GA QL533 UT WOS:A1995QL53300024 PM 7735809 ER PT J AU WALSH, ME AF WALSH, ME TI ANALYTICAL METHOD FOR WHITE PHOSPHORUS IN WATER SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article RP WALSH, ME (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 20 TC 6 Z9 6 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0007-4861 J9 B ENVIRON CONTAM TOX JI Bull. Environ. Contam. Toxicol. PD MAR PY 1995 VL 54 IS 3 BP 432 EP 439 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA QD256 UT WOS:A1995QD25600018 PM 7749278 ER PT J AU HONG, MK WONG, SC FARB, A MEHLMAN, MD VIRMANI, R BARRY, JJ LEON, MB AF HONG, MK WONG, SC FARB, A MEHLMAN, MD VIRMANI, R BARRY, JJ LEON, MB TI LOCALIZED DRUG-DELIVERY IN ATHEROSCLEROTIC ARTERIES VIA A NEW BALLOON ANGIOPLASTY CATHETER WITH INTRAMURAL CHANNELS FOR SIMULTANEOUS LOCAL-DRUG DELIVERY SO CATHETERIZATION AND CARDIOVASCULAR DIAGNOSIS LA English DT Article DE INTRAMURAL CHANNELS; EXTERIOR PORES; ANGIOPLASTY ID SMOOTH-MUSCLE CELLS; HYPERCHOLESTEROLEMIC RABBIT; MYOINTIMAL PROLIFERATION; GENE-TRANSFER; HEPARIN; CORONARY; INVIVO; RESTENOSIS; INJURY; WALL AB A dual-purpose angioplasty catheter with intramural channels and exterior pores for local drug delivery (''channeled balloon'') was studied in eight atherosclerotic human necropsy arteries and in 22 rabbits with atherosclerotic peripheral arteries, in which markers (0.005 mum to 15 mum) were infused locally at 2 atmospheres during simultaneous angioplasty of 6 atmospheres. Thirteen of the rabbits were sacrificed at 4 or 24 h after procedure to determine the intramural retention over time. Histology confirmed effective angioplasty and revealed presence of markers in the arterial wall in 29 of 43 treated arteries (67%), whereas all control segments without local delivery had no marker staining. Majority of the ineffective local delivery (12/14) occurred when 15 mum particles were infused (12/13 arteries without intramural markers), especially when examined 4 or 24 h later. Thus, in atherosclerotic arteries, the channeled balloon enabled simultaneous local drug delivery at low pressure during effective angioplasty, although particle size may play a role in successful intramural impregnation and retention. (C) 1995 Wiley-Liss, Inc. C1 WASHINGTON HOSP CTR,DEPT INTERNAL MED,DIV CARDIOL,WASHINGTON,DC 20010. USA,INST PATHOL,DIV CARDIOVASC,WASHINGTON,DC 20310. MANSFIELD BOSTON SCI CORP,WATERTOWN,MA. NR 27 TC 14 Z9 14 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0098-6569 J9 CATHETER CARDIO DIAG JI Catheter. Cardiovasc. Diagn. PD MAR PY 1995 VL 34 IS 3 BP 263 EP 270 DI 10.1002/ccd.1810340122 PG 8 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA QK021 UT WOS:A1995QK02100021 PM 7497498 ER PT J AU WINSLOW, RL CAI, DM VARGHESE, A LAI, YC AF WINSLOW, RL CAI, DM VARGHESE, A LAI, YC TI GENERATION AND PROPAGATION OF NORMAL AND ABNORMAL PACEMAKER ACTIVITY IN NETWORK MODELS OF CARDIAC SINUS NODE AND ATRIUM SO CHAOS SOLITONS & FRACTALS LA English DT Article ID MASSIVELY PARALLEL COMPUTER; GAP JUNCTIONAL CHANNELS; RAT-HEART; CALCIUM-CONCENTRATION; INTRACELLULAR SODIUM; CONNECTION MACHINE; STRANGE ATTRACTORS; PURKINJE-FIBERS; CELL NETWORKS; FERRET HEARTS AB Effects of cell-to-cell coupling conductance on dynamics of sinus node cells are examined. Cell models are biophysically detailed, and are based on the kinetic equations developed by Noble ct al. [Neuronal and Cellular Oscillators, edited by J. W. Jacklet. Marcel Deckker, New York (1989).] Resistively coupled cell pairs show five regimes of behavior as a function of coupling conductance: (1) independent oscillation for G(c) < 1 pS; (2) primarily quasiperiodic oscillation for 1 less than or equal to G(c) < 116 pS; (3) windows of periodic behavior which undergo period doubling bifurcation to chaos for 116 less than or equal to G(c) < 212 pS; (4) frequency entrainment for G(c) greater than or equal to 212 pS; (5) waveform entrainment for G(c) greater than or equal to 50 nS. Thus, only 4-5 gap junction channels are required for frequency entrainment. This is shown to also be the case for large networks of sinus cells modeled on the Connection Machine CM-5. A biophysically detailed two-dimensional network model of the cardiac atrium has also been implemented on the CM-5 supercomputer. The model is used to study effects of spatially localized inhibition of the Na-K pump. Na overloading produced by pump inhibition can induce spontaneous, propagating ectopic beats within the network. At a cell-to-cell coupling value yielding a realistic plane wave conduction velocity of 60 cms(-1) pump inhibition in small regions of the network containing as few as 1000 cells can induce propagating ectopic beats. C1 UNIV MINNESOTA,BIOMED ENGN PROGRAM,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,USA,HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. RP WINSLOW, RL (reprint author), JOHNS HOPKINS UNIV,SCH MED,DEPT BIOMED ENGN,BALTIMORE,MD 21205, USA. NR 51 TC 24 Z9 25 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0960-0779 J9 CHAOS SOLITON FRACT JI Chaos Solitons Fractals PD MAR-APR PY 1995 VL 5 IS 3-4 BP 491 EP 512 DI 10.1016/0960-0779(93)E0038-D PG 22 WC Mathematics, Interdisciplinary Applications; Physics, Multidisciplinary; Physics, Mathematical SC Mathematics; Physics GA QR953 UT WOS:A1995QR95300016 ER PT J AU WAAG, DM MCKEE, KT SANDSTROM, G PRATT, LLK BOLT, CR ENGLAND, MJ NELSON, GO WILLIAMS, JC AF WAAG, DM MCKEE, KT SANDSTROM, G PRATT, LLK BOLT, CR ENGLAND, MJ NELSON, GO WILLIAMS, JC TI CELL-MEDIATED AND HUMORAL IMMUNE-RESPONSES AFTER VACCINATION OF HUMAN VOLUNTEERS WITH THE LIVE VACCINE STRAIN OF FRANCISELLA-TULARENSIS SO CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY LA English DT Article ID POLYACRYLAMIDE GELS; HUMAN TULAREMIA; DIAGNOSIS; AGGLUTININS; STIMULATION; INFECTION; PROTEINS; DISEASE AB The specific humoral and cell-mediated immune responses of human volunteers vaccinated with the Francisella tularensis live vaccine strain (LVS) were evaluated. In the search for an optimal antigen to measure the immunogenicity of the vaccine in an enzyme-linked immunosorbent assay, we tested irradiation-killed LVS, an aqueous ether extract of the LVS (EEx), lipopolysaccharide (LPS) from LVS, and a virulent strain (SCHU4). Volunteers were immunized with LVS by scarification. Immunoglobulin G (IgG) responses to LVS and LPS gave the highest background titers when tested with sera from unimmunized volunteers, whereas IgA, IgG, and IgM background titers to EEx and SCHU4 were low. Vaccination caused a significant rise (P < 0.01) in IgA, IgG, and IgM titers to all antigens tested, except for the IgG response to LPS. Eighty percent of vaccinated volunteers developed a positive IgG response to EEx 14 days postvaccination, while 50% were positive to LVS. By day 14 after vaccination, 70% of immunized volunteers exhibited a positive response to EEx in an in vitro peripheral blood lymphocyte proliferation assay. EEx, a specific and sensitive antigen for evaluating immune responses of vaccinated volunteers, may be a superior antigen for the diagnosis of tularemia. C1 USA,MED RES INST INFECT DIS,DIV MED,FT DETRICK,MD 21702. USA,MED RES INST INFECT DIS,DIV BIOMETR & INFORMAT MANAGEMENT,FT DETRICK,MD 21702. US FDA,CTR BIOL EVALUAT & RES,OFF VACCINES RES & REVIEW,DIV VACCINES & RELATED PROD APPLICAT,BETHESDA,MD 20892. UMEA UNIV,DEPT INFECT DIS,S-90185 UMEA,SWEDEN. NATL DEF RES ESTAB,DEPT MICROBIOL,S-90182 UMEA,SWEDEN. RP WAAG, DM (reprint author), USA,MED RES INST INFECT DIS,DIV BACTERIOL,PATHOGENESIS & IMMUNOL BRANCH,FT DETRICK,MD 21702, USA. NR 24 TC 30 Z9 31 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 1071-412X J9 CLIN DIAGN LAB IMMUN JI Clin. Diagn. Lab. Immunol. PD MAR PY 1995 VL 2 IS 2 BP 143 EP 148 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA QK802 UT WOS:A1995QK80200004 PM 7697521 ER PT J AU GOMEZ, ER AF GOMEZ, ER TI SATELLITE LINKS WORLD HOT-SPOTS TO WALTER-REED-HOSPITAL SO COMMUNICATIONS NEWS LA English DT Article RP GOMEZ, ER (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NELSON PUBLISHING PI NOKOMIS PA 2504 NORTH TAMIAMI TRAIL, NOKOMIS, FL 34275-3482 SN 0010-3632 J9 COMMUN NEWS JI Commun. News PD MAR PY 1995 VL 32 IS 3 BP 12 EP 12 PG 1 WC Telecommunications SC Telecommunications GA QK805 UT WOS:A1995QK80500004 ER PT J AU SATAVA, RM AF SATAVA, RM TI VIRTUAL-REALITY AND TELEPRESENCE FOR MILITARY MEDICINE SO COMPUTERS IN BIOLOGY AND MEDICINE LA English DT Article DE VIRTUAL REALITY; TELEPRESENCE; ARTIFICIAL INTELLIGENCE; COMBAT CASUALTY CARE; MILITARY MEDICINE; SURGICAL SIMULATION ID SURGERY; FUTURE AB The profound changes brought about by technology in the past few decades are leading to a total revolution in medicine. The advanced technologies of telepresence and virtual reality are but two of the manifestations emerging from our new information age; now all of medicine can be empowered because of this digital technology. The leading edge is on the digital battlefield, where an entire new concept in military medicine is evolving. Using remote sensors, intelligent systems, telepresence surgery and virtual reality surgical simulations, combat casualty care is prepared for the 21st century. C1 ADV RES PROJECTS AGCY,ARLINGTON,VA 22203. RP SATAVA, RM (reprint author), UNIFORMED SERV UNIV HLTH SCI,WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 8 TC 28 Z9 29 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0010-4825 J9 COMPUT BIOL MED JI Comput. Biol. Med. PD MAR PY 1995 VL 25 IS 2 BP 229 EP 236 DI 10.1016/0010-4825(94)00006-C PG 8 WC Biology; Computer Science, Interdisciplinary Applications; Engineering, Biomedical; Mathematical & Computational Biology SC Life Sciences & Biomedicine - Other Topics; Computer Science; Engineering; Mathematical & Computational Biology GA RF807 UT WOS:A1995RF80700014 PM 7554840 ER PT J AU HEWITT, AD GRANT, CL AF HEWITT, AD GRANT, CL TI ROUND-ROBIN STUDY OF PERFORMANCE EVALUATION SOILS VAPOR-FORTIFIED WITH VOLATILE ORGANIC-COMPOUNDS SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article AB Three soils were vapor-fortified with volatile organic compounds (VOCs) to produce materials suitable for performance evaluation and related quality assurance/quality control (QA/QC) functions. Twelve laboratories analyzed two independently prepared sets of three different soil subsamples fortified with trans- 1,2-dichloroethylene (TDCE), trichloroethylene (TCE), benzene (Ben), and toluene (Tol). Analyte concentration estimates were reported for each soil subsample following a methanol extraction, purge- and-trap gas chromatography/mass spectrometry analysis (Method 8240, SW846). Relative standard deviations within individual soils ranged from 8.5 to 28.2%, with a pooled standard deviation of < 13%. The best precision was for Ben (pooled RSD, 9.0%), while TDCE showed the greatest overall un certainty (pooled RSD, 20.3%). These results confirm that vapor fortification, followed by confinement in sealed glass ampules, is a precise means of preparing and storing VOC-contaminated soil subsamples for use in quality assurance programs. C1 UNIV NEW HAMPSHIRE,DURHAM,NH 03824. RP HEWITT, AD (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 22 TC 11 Z9 11 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD MAR PY 1995 VL 29 IS 3 BP 769 EP 774 DI 10.1021/es00003a026 PG 6 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA QJ908 UT WOS:A1995QJ90800041 PM 22200287 ER PT J AU KAPLAN, M AF KAPLAN, M TI THE CULTURE AT WORK - CULTURAL ERGONOMICS SO ERGONOMICS LA English DT Article DE CULTURAL ERGONOMICS; CODIFYING CULTURAL INFLUENCES; GLOBAL WORKPLACE; AVIATION AEROSPACE EXIGENCIES; IMPLEMENTING TRANSFERRED TECHNOLOGY; TASK PERFORMANCE AB With the subject matter of ergonomics increasingly broadly conceived, a need is suggested for the systematization and codification of cultural influences on the wide-ranging elements of the field. Pertinent types of systematic analysis, basic and applied research, and training are viewed as necessary, both (a) to generate new knowledge, and (b) to develop culturally appropriate user applications that are important for varied work environments world-wide. C1 USA,RES INST,ALEXANDRIA,VA 22333. NR 40 TC 6 Z9 6 U1 2 U2 5 PU TAYLOR & FRANCIS LTD LONDON PI LONDON PA ONE GUNDPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 0014-0139 J9 ERGONOMICS JI Ergonomics PD MAR PY 1995 VL 38 IS 3 BP 606 EP 615 DI 10.1080/00140139508925134 PG 10 WC Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Engineering; Psychology GA QM935 UT WOS:A1995QM93500021 ER PT J AU UNDERWOOD, JH AF UNDERWOOD, JH TI RESIDUAL-STRESS EFFECTS AT A NOTCH ROOT IN A723 STEEL TO EXTEND FATIGUE LIFE SO EXPERIMENTAL MECHANICS LA English DT Article AB Fatigue-life tests were performed with notched bend specimens of ASTM A723 steel with three types of notch treatment and resulting residual stress; shot peening, hole swaging, and tensile overload. The three notch treatments produced widely different depths and surface values of residual stress near the notch root and different fatigue lives, dependent mainly on the notch root surface value of compressive residual stress. The highest life was measured from overload specimens, which had both the deepest and the highest surface-value residual-stress distribution. Fracture-mechanics-based calculations of fatigue life agree well with measurements. The calculations account for the following factors which affect fatigue life: the crack-growth properties of the material; the shallow surface-crack configuration; the applied loading; and the depth and surface magnitude of the residual-stress distribution. A consistent description of fatigue life was obtained from a DELTAK versus calculated life plot, where the DELTAK is that for a shallow crack near the notch root and in the region of compressive residual stress. A power-law relationship between DELTAK and life agrees well with the results from both the untreated notches and those with the three types of residual stress, indicating that life predictions could be made with some confidence for tests under generally similar conditions. RP UNDERWOOD, JH (reprint author), USA,CTR ARMAMENT RD&E,BENET LABS,BLDG 115,WATERVLIET,NY 12189, USA. NR 8 TC 3 Z9 3 U1 0 U2 0 PU SOC EXPERIMENTAL MECHANICS PI BETHEL PA 7 SCHOOL STREET, BETHEL, CT 06801 SN 0014-4851 J9 EXP MECH JI Exp. Mech. PD MAR PY 1995 VL 35 IS 1 BP 61 EP 65 DI 10.1007/BF02325836 PG 5 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing SC Materials Science; Mechanics GA QR053 UT WOS:A1995QR05300010 ER PT J AU CHARLAB, R TESH, RB ROWTON, ED RIBEIRO, JMC AF CHARLAB, R TESH, RB ROWTON, ED RIBEIRO, JMC TI LEISHMANIA-AMAZONENSIS - SENSITIVITY OF DIFFERENT PROMASTIGOTE MORPHOTYPES TO SALIVARY-GLAND HOMOGENATES OF THE SAND FLY LUTZOMYIA-LONGIPALPIS SO EXPERIMENTAL PARASITOLOGY LA English DT Article DE LEISHMANIA AMAZONENSIS; PARASITIC PROTOZOA; PROMASTIGOTE MORPHOTYPES; PROLIFERATION AND DIFFERENTIATION; SAND FLY LEISHMANIA INTERACTION; LUTZOMYIA LONGIPALPIS; PHLEBOTOMINE SAND FLIES; SALIVARY GLAND HOMOGENATES; BRAIN HEART INFUSION MEDIUM; HEAT-INACTIVATED FETAL CALF SERUM ID PSYCHODIDAE; DIPTERA; STAGE AB We have recently demonstrated that Luizomyia longipalpis salivary gland homogenates (SGH) inhibited the multiplication of Leishmania promastigotes in vitro. The present work shows that Leishmania amazonensis sensitivity to SGH is correlated to the phase of promastigote in vitro growth and can be decreased by the addition of hemin to the culture medium. The possible relevance of these in vitro results is discussed in relation to the development of Leishmania parasites within their sand fly vectors. (C) 1995 Academic Press, Inc. C1 UNIV ARIZONA,DEPT ENTOMOL,TUCSON,AZ 85721. YALE UNIV,SCH MED,DEPT EPIDEMIOL & PUBL HLTH,YALE ARBOVIRUS RES UNIT,NEW HAVEN,CT 06510. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. RI Rowton, Edgar/A-4474-2012; Rowton, Edgar/A-1975-2011; OI Rowton, Edgar/0000-0002-1979-1485; Ribeiro, Jose/0000-0002-9107-0818 FU NIAID NIH HHS [AI-21049] NR 13 TC 14 Z9 15 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 SN 0014-4894 J9 EXP PARASITOL JI Exp. Parasitol. PD MAR PY 1995 VL 80 IS 2 BP 167 EP 175 DI 10.1006/expr.1995.1021 PG 9 WC Parasitology SC Parasitology GA QP934 UT WOS:A1995QP93400001 PM 7895828 ER PT J AU DIGGS, CL HINES, F WELLDE, BT AF DIGGS, CL HINES, F WELLDE, BT TI PLASMODIUM-FALCIPARUM - PASSIVE-IMMUNIZATION OF AOTUS-LEMURINUS GRISEIMEMBRA WITH IMMUNE SERUM SO EXPERIMENTAL PARASITOLOGY LA English DT Article AB Owl monkeys (Aotus lemurinus griseimembra) were immunized against Plasmodium falciparum by infection and drug cure. After challenge, 3 of 4 monkeys developed extended prepatent periods and low grade parasitemias followed by self cure. The fourth monkey did not develop a patent infection. Immune monkey serum passively transferred at the time of challenge conferred immunity to 20 naive monkeys. Immunity was characterized by extended prepatent periods in 19 monkeys, low levels of parasitemia (less than or equal to 1%) followed by self cure in 12 animals, and lack of detectable infection in 3 recipient monkeys, Immune serum collected from monkeys undergoing repeated challenges afforded more protection than serum from singly infected monkeys. However, single doses of hyperimmune serum appeared to be as effective as multiple doses. Normal serum had no effect on the course of infection in 12 monkeys. These studies confirm that owl monkeys can be immunized by infection and cure and demonstrate that this immunity can, in large part, be transferred to nonimmune recipients with serum from immune donors. (C) 1995 Academic Press, Inc. C1 US FDA,CTR FOOD SAFETY & APPL NUTR,OFF SCI ANAL & SUPPORT,DIV GEN SCI SUPPORT,WASHINGTON,DC 20204. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307. RP DIGGS, CL (reprint author), JOHNS HOPKINS UNIV,DEPT INT HLTH,103 E MT ROYAL AVE,2B,BALTIMORE,MD 21202, USA. NR 16 TC 8 Z9 9 U1 1 U2 2 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 SN 0014-4894 J9 EXP PARASITOL JI Exp. Parasitol. PD MAR PY 1995 VL 80 IS 2 BP 291 EP 296 DI 10.1006/expr.1995.1035 PG 6 WC Parasitology SC Parasitology GA QP934 UT WOS:A1995QP93400015 PM 7895839 ER PT J AU KOVACS, A HOLLADAY, JS BERGERON, CJ AF KOVACS, A HOLLADAY, JS BERGERON, CJ TI THE FOOTPRINT ALTITUDE RATIO FOR HELICOPTER ELECTROMAGNETIC SOUNDING OF SEA-ICE THICKNESS - COMPARISON OF THEORETICAL AND FIELD ESTIMATES SO GEOPHYSICS LA English DT Article ID AIRBORNE AB Helicopter-towed electromagnetic (HEM) induction sounding systems are typically used for geologic surveys. More recently, HEM systems have been used for the remote measurement of sea-ice thickness and shallow sea bathymetry. An important aspect of this remote sensing technology is the area, or footprint, in which the secondary field is predominantly generated by induced currents. A knowledge of the size of the footprint is important to understanding the accuracy of HEM sounding results over lateral variations in relief or conductivity. Conventional wisdom among workers in the field held that the footprint diameter is a few times the HEM antenna altitude. We confirm this view using airborne measurements over sea ice to calculate the footprint size/antenna altitude ratio. These findings are compared to various theoretical estimates and are found to be in reasonable agreement. For a vertical coaxial coil antenna arrangement, the apparent footprint diameter was found to be about 1.3 times the antenna height above the sea-ice/water interface, and for a horizontal coplanar coil figuration the ratio is about 3.8 times the antenna height. C1 GEONEX AERODAT INC,MISSISSAUGA,ON L4V 1R3,CANADA. UNIV NEW ORLEANS,DEPT PHYS,NEW ORLEANS,LA 70148. UNIV NEW ORLEANS,GEOPHYS RES LAB,NEW ORLEANS,LA 70148. RP KOVACS, A (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 10 TC 46 Z9 49 U1 0 U2 0 PU SOC EXPLORATION GEOPHYSICISTS PI TULSA PA 8801 S YALE ST, TULSA, OK 74137 SN 0016-8033 J9 GEOPHYSICS JI Geophysics PD MAR-APR PY 1995 VL 60 IS 2 BP 374 EP 380 DI 10.1190/1.1443773 PG 7 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA QN687 UT WOS:A1995QN68700006 ER PT J AU GABR, MA AKRAM, M TAYLOR, HM AF GABR, MA AKRAM, M TAYLOR, HM TI EFFECT OF SIMULATED ROOTS ON THE PERMEABILITY OF SILTY SOIL SO GEOTECHNICAL TESTING JOURNAL LA English DT Note DE HYDRAULIC CONDUCTIVITY; LEVEE; PERMEABILITY; ROOTS AB A preliminary laboratory testing program was conducted to investigate the potential effect of vegetation on the hydraulic conductivity of soils used to construct levee structures. The testing program was conducted using a silty sand soil with a simulated root system. Testing apparatus included rigid-wall-double-ring permeameters and flexible-wall permeameters. The simulated roots were made using Balsa wood having a square cross section of 1.65 by 1.65 mm and approximately 12 to 25 mm in length. The measured hydraulic conductivity for specimens without simulated roots decreased as a function of the moisture content from approximately 1 X 10(-3) cm/s to 5 X 10(-4) cm/s. Values obtained using the flexible-wall device were less than those measured using the rigid-wall device by a factor of approximately 2. The addition of 1% simulated roots decreased the measured hydraulic conductivity, k. The reduction in k increased from less than 10% at a molding water content of 10% to approximately 50% at a water content of 25%. Similar behavior was observed in the case of specimens with 2% simulated roots. For gamma(dry) of 10 kN/m(3), the estimated k values were 1 X 10 5 cm/s for the case of 2% roots versus 3 x 10(-4) cm/s for the case of 1% roots. The k values decreased as the unit weight of the specimens was increased for both cases. In addition, the difference between k values obtained for specimens containing 1% and specimens containing 2% simulated roots increased as the dry unit weight of the specimens was increased. C1 W VIRGINIA UNIV,DEPT CIVIL ENGN,MORGANTOWN,WV 26506. USA,CORPS ENGINEERS,GEOTECH LAB,WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP GABR, MA (reprint author), W VIRGINIA UNIV,DEPT CIVIL & ENVIRONM ENGN,BOX 6101,MORGANTOWN,WV 26506, USA. OI Gabr, Mohammed/0000-0001-6396-9730 NR 2 TC 4 Z9 4 U1 2 U2 3 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0149-6115 J9 GEOTECH TEST J JI Geotech. Test. J. PD MAR PY 1995 VL 18 IS 1 BP 112 EP 115 PG 4 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA QM140 UT WOS:A1995QM14000011 ER PT J AU POSNER, GH OH, CH GERENA, L MILHOUS, WK AF POSNER, GH OH, CH GERENA, L MILHOUS, WK TI SYNTHESIS AND ANTIMALARIAL ACTIVITIES OF STRUCTURALLY SIMPLIFIED 1,2,4-TRIOXANES RELATED TO ARTEMISININ SO HETEROATOM CHEMISTRY LA English DT Article ID SOLUBLE DIHYDROARTEMISININ DERIVATIVES; QINGHAOSU ARTEMISININ; ANALOGS; ACID; CONVERSION; DEOXOQINGHAOSU; CHEMISTRY; KETONES; INVITRO AB Eleven derivatives of the clinically useful, antimalarial, 1,2,4-trioxane artemisinin have been synthesized in only several steps from commercial cyclohexanones. Of these simple, tricyclic 1,2,4-trioxanes, 10 showed considerable in vitro antimalarial activity, with one being as potent as artemisinin. Some structure-activity relationship generalizations are made from this series of artemisinin analogs. Triethylsilyl hydrotrioxide (Et(3)SiOOOH), prepared in situ from ozone and triethylsilane, is shown to be a mild, fast-acting, and effective dioxetane-forming reagent with vinyl ethers and with a vinyl thioether on relatively small (50-100 mg) scale. C1 WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, DIV EXPTL THERAPEUT, WASHINGTON, DC 20307 USA. RP POSNER, GH (reprint author), JOHNS HOPKINS UNIV, DEPT CHEM, CHARLES & 34TH ST, BALTIMORE, MD 21218 USA. NR 59 TC 29 Z9 29 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1042-7163 J9 HETEROATOM CHEM JI Heteroatom Chem. PD MAR-APR PY 1995 VL 6 IS 2 BP 105 EP 116 DI 10.1002/hc.520060205 PG 12 WC Chemistry, Multidisciplinary SC Chemistry GA RK337 UT WOS:A1995RK33700004 ER PT J AU KING, CS AF KING, CS TI D-DAY JUNE 6, 1944 - THE CLIMATIC BATTLE OF WORLD-WAR-II - AMBROSE,SE SO HISTORIAN LA English DT Book Review RP KING, CS (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU PHI ALPHA THETA PI ALLENTOWN PA THE HISTORIAN 2333 LIBERTY STREET, ALLENTOWN, PA 18104 SN 0018-2370 J9 HISTORIAN JI Historian PD SPR PY 1995 VL 57 IS 3 BP 655 EP 656 PG 2 WC History SC History GA QX547 UT WOS:A1995QX54700078 ER PT J AU MILLER, JR AF MILLER, JR TI SINGLE MEASUREMENT TESTING, PROS AND CONS SO IEEE AEROSPACE AND ELECTRONIC SYSTEMS MAGAZINE LA English DT Article AB There is a school of thought that believes making a single measurement of some parameter is a proper test procedure. For reasons of speed and the large number of measurements to be made on an item, so the reasoning goes, one cannot afford to make multiple measurements, calculate the average and the variation of the readings. What are the consequences of this approach? Can one test a unit to its specifications using this approach? What are the trade-offs inherent in single measurement testing? What happens if an erratic unit is tested? An alternative testing method involves taking a few repeat values, averaging them and estimating their repeatability. The same set of questions apply. The pros and cons of these two approaches will be discussed. Practical real world examples will be presented. RP MILLER, JR (reprint author), USA,TMDE ACT,REDSTONE ARSENAL,AL 35898, USA. NR 0 TC 5 Z9 7 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-8985 J9 IEEE AERO EL SYS MAG JI IEEE Aerosp. Electron. Syst. Mag. PD MAR PY 1995 VL 10 IS 3 BP 35 EP 39 DI 10.1109/62.391913 PG 5 WC Engineering, Aerospace; Engineering, Electrical & Electronic SC Engineering GA QM903 UT WOS:A1995QM90300008 ER PT J AU TORRIERI, D BAKHRU, K AF TORRIERI, D BAKHRU, K TI PERFORMANCE OF RECURSIVE SUPPRESSION ALGORITHM IN NONSTATIONARY ENVIRONMENTS SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article ID MUSIC AB Adaptive superresolution algorithms possess the inherent ability to adapt to nonstationary environments, In this paper, the recursive suppression algorithm is shown to provide much better resolution than the MUSIC algorithm when the average signal-to-noise ratios at array outputs are low and there are power variations or there is relative motion between the array and closely spaced signal sources. An implementation of the recursive suppression algorithm using digital signal processing is presented. C1 CUB DEF SYST INC,SAN DIEGO,CA. RP TORRIERI, D (reprint author), USA,AMSRL,SS,IB,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 9 TC 3 Z9 3 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD MAR PY 1995 VL 43 IS 3 BP 299 EP 307 DI 10.1109/8.372000 PG 9 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA QN930 UT WOS:A1995QN93000011 ER PT J AU FRASIER, SJ LIU, Y MOLLER, D MCINTOSH, RE LONG, C AF FRASIER, SJ LIU, Y MOLLER, D MCINTOSH, RE LONG, C TI DIRECTIONAL OCEAN WAVE MEASUREMENTS IN A COASTAL SETTING USING A FOCUSED ARRAY IMAGING RADAR SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article ID SYNTHETIC APERTURE RADAR; GRAVITY-WAVES; SPECTRA AB A unique focused array imaging Doppler radar was used to measure directional spectra of ocean surface waves in a nearshore experiment performed on the North Carolina Outer Banks. Radar images of the ocean surface's Doppler velocity were used to generate two dimensional spectra of the radial component of the ocean surface velocity field. These are compared to simultaneous in-situ measurements made by a nearby array of submerged pressure sensors. Analysis of the resulting two-dimensional spectra include comparisons of dominant wave lengths, wave directions, and wave energy accounting for relative differences in water depth at the measurement locations. Limited estimates of the two-dimensional surface displacement spectrum are derived from the radar data. The radar measurements are analogous to those of interferometric synthetic aperture radars (INSAR), and the equivalent INSAR parameters are shown. The agreement between the remote and in-situ measurements suggests that an imaging Doppler radar is effective for these wave measurements at near grazing incidence angles. C1 USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,FIELD RES FACIL,DUCK,NC. RP FRASIER, SJ (reprint author), UNIV MASSACHUSETTS,MICROWAVE REMOTE SENSING LAB,AMHERST,MA 01003, USA. RI Frasier, Stephen/H-1536-2015 OI Frasier, Stephen/0000-0003-4287-2889 NR 23 TC 21 Z9 21 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD MAR PY 1995 VL 33 IS 2 BP 428 EP 440 DI 10.1109/36.377943 PG 13 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA QN940 UT WOS:A1995QN94000021 ER PT J AU PAOLELLA, A MALONE, S BERCELI, T HERCZFELD, PR AF PAOLELLA, A MALONE, S BERCELI, T HERCZFELD, PR TI MMIC COMPATIBLE LIGHTWAVE-MICROWAVE MIXING TECHNIQUE SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article AB The work presented here concerns the mixing of a microwave signal with a modulated optical signal in a MESFET, A brief theoretical analysis of the mixing mechanism is given in terms of the input signal parameters and device characteristics. Experimental results for the IF response of the MESFET as a function of RF frequency, incident optical power, optical modulation depth and gate bias voltage are shown, The IF response and the noise figure of the MESFET below 700 MHz were smaller than those of a p-i-n detector/Schottky mixer combination. C1 DREXEL UNIV,CTR MICROWAVE LIGHTWAVE ENGN,PHILADELPHIA,PA 19104. TECH UNIV BUDAPEST,TELECOMMUN RES INST,BUDAPEST,HUNGARY. RP PAOLELLA, A (reprint author), USA,RES LAB,FT MONMOUTH,NJ, USA. NR 11 TC 12 Z9 12 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD MAR PY 1995 VL 43 IS 3 BP 518 EP 522 DI 10.1109/22.372095 PG 5 WC Engineering, Electrical & Electronic SC Engineering GA QM887 UT WOS:A1995QM88700007 ER PT J AU STOUTE, JA BALLOU, WR KOLODNY, N DEAL, CD WIRTZ, RA LINDLER, LE AF STOUTE, JA BALLOU, WR KOLODNY, N DEAL, CD WIRTZ, RA LINDLER, LE TI INDUCTION OF HUMORAL IMMUNE-RESPONSE AGAINST PLASMODIUM-FALCIPARUM SPOROZOITES BY IMMUNIZATION WITH A SYNTHETIC PEPTIDE MIMOTOPE WHOSE SEQUENCE WAS DERIVED FROM SCREENING A FILAMENTOUS PHAGE EPITOPE LIBRARY SO INFECTION AND IMMUNITY LA English DT Article ID HUMAN MALARIA PARASITES; CIRCUMSPOROZOITE PROTEIN; ESCHERICHIA-COLI; VACCINE; IMMUNOGENICITY; EXPRESSION; MOLECULES; ANTIBODY; LIGANDS AB The mouse monoclonal antibody 2A10 (immunoglobulin G), which recognizes the (NANP)(n) repeat of Plasmodium falciparum circumsporozoite surface protein, was used to screen a filamentous phage epitope library expressing random amino acid hexamers. The sequences obtained were TNRNPQ, SNRNPQ, NND-NPQ, SNYNPQ, and QNDNPQ (single-letter amino acid designation). These peptides showed 50% homology with the native epitope (PNANPN) and therefore were considered to mimic its structure (mimotopes). Two of these mimotopes (TNRNPQ and NNDNPQ) inhibited the binding of monoclonal antibody 2A10 to the recombinant protein R32LR, which contains the amino acid sequence [(NANP)(15)NVDP](2). Immunization of mice and rabbits using the peptide (TNRNPQ)(4) induced a humoral response that recognized R32LR by an enzyme-linked immunosorbent assay and P. falciparum sporozoites by an immunofluorescence assay. These results suggest that phage epitope libraries can be exploited to screen for mimotopes in the design of subunit vaccines against infectious agents. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT MED,INFECT DIS SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTOMOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. RP STOUTE, JA (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT IMMUNOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307, USA. NR 30 TC 31 Z9 33 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD MAR PY 1995 VL 63 IS 3 BP 934 EP 939 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA QJ524 UT WOS:A1995QJ52400028 PM 7532629 ER PT J AU ISHIHARA, S TAKINO, M OKADA, Y MIMURA, K AF ISHIHARA, S TAKINO, M OKADA, Y MIMURA, K TI SEPTIC SHOCK DUE TO PSEUDOMONAS-AERUGINOSA IN A PREVIOUSLY HEALTHY WOMAN SO INTENSIVE CARE MEDICINE LA English DT Note DE PSEUDOMONAS-AERUGINOSA; SEPTICEMIA; SEPTIC SHOCK AB Pseudomonas aeruginosa septicemia rarely occurs in non-immunocompromised adults. We present a case of septic shock following Pseudomonas aeruginosa pneumonia in a previously healthy 48-year-old woman. The onset was sudden, with back pain, pyrexia and shock. Chest radiographs revealed pneumonia, and Pseudomonas aeruginosa was identified from blood and sputum cultures. Therapy with dopamine, piperacillin and fluid replacement led to a prompt recovery. Laboratory tests failed to reveal any immunological deficits. Including this case, only five cases of Pseudomonas aeruginosa septicemia in patients though to be non-immunocompromised have been reported. Two remarkable features of this type of Pseudomonas infection are apparent: i) it commonly develops from pneumonia and ii) it has a better prognosis than that in immunocompromised hosts. C1 NATL DEF MED COLL,DEPT TRAUMATOL & CRIT CARE MED,TOKOROZAWA,SAITAMA 359,JAPAN. RP ISHIHARA, S (reprint author), USA,INST SURG RES,FT SAM HOUSTON,TX 78234, USA. NR 10 TC 5 Z9 5 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0342-4642 J9 INTENS CARE MED JI Intensive Care Med. PD MAR PY 1995 VL 21 IS 3 BP 226 EP 228 DI 10.1007/BF01701476 PG 3 WC Critical Care Medicine SC General & Internal Medicine GA QM303 UT WOS:A1995QM30300006 PM 7790608 ER PT J AU KAMIMORI, GH LUGO, SI PENETAR, DM CHAMBERLAIN, AC BRUNHART, GE BRUNHART, AE EDDINGTON, ND AF KAMIMORI, GH LUGO, SI PENETAR, DM CHAMBERLAIN, AC BRUNHART, GE BRUNHART, AE EDDINGTON, ND TI DOSE-DEPENDENT CAFFEINE PHARMACOKINETICS DURING SEVERE SLEEP-DEPRIVATION IN HUMANS SO INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS LA English DT Article DE CAFFEINE; SLEEP DEPRIVATION; ORAL PHARMACOKINETICS; METABOLISM ID DISPOSITION; EXERCISE AB Following 49 h of sleep deprivation, 37 healthy males ingested either 2.1, 4.3, or 8.6 mg*kg(-1) body weight of caffeine in a randomized double-blind design, Subjects were sleep deprived for additional 12 h and venous blood samples were collected intermittently. Caffeine and primary metabolite concentrations were determined by HPLC. Pharmacokinetics were computed using the Lagran computer program. The ratio of the primary human metabolite, paraxanthine, to caffeine was used to estimate the rate of metabolism. There was a significant (p < 0.05) and disproportional increase in the dose normalized caffeine AUC and a significant decrease in its clearance associated with increasing dose. In addition, the paraxanthine to caffeine ratio significantly decreased with an increase in dose, indicating that the rate of caffeine metabolism decreased. These results demonstrate that under the conditions of severe sleep deprivation caffeine exhibits dose-dependent pharmacokinetics. In addition, these results are consistent with a model of capacity-limited metabolism. C1 UNIV MARYLAND,DEPT PHARMACEUT,PHARMACOKINET BIOPHARMACEUT LAB,BALTIMORE,MD 21201. RP KAMIMORI, GH (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BEHAV BIOL,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307, USA. NR 15 TC 21 Z9 21 U1 1 U2 4 PU DUSTRI-VERLAG DR KARL FEISTLE PI MUNCHEN-DEISENHOFEN PA BAHNHOFSTRABE 9 POSTFACH 49, W-8024 MUNCHEN-DEISENHOFEN, GERMANY SN 0946-1965 J9 INT J CLIN PHARM TH JI Int. J. Clin. Pharmacol. Ther. PD MAR PY 1995 VL 33 IS 3 BP 182 EP 186 PG 5 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA QM135 UT WOS:A1995QM13500010 PM 7599918 ER PT J AU SHUKLA, YN GORDON, RK KAPADIA, GJ AF SHUKLA, YN GORDON, RK KAPADIA, GJ TI SYNTHESIS AND ANTIMUSCARINIC ACTIVITY OF TROPINE NONANOATE SO INTERNATIONAL JOURNAL OF PHARMACOGNOSY LA English DT Note DE ANTIMUSCARINIC; TROPINE ANALOG; SYNTHESIS; RADIOLIGAND BINDING ASSAY ID ANALOGS AB The recently isolated tropine nonanoate from Duboisia myoporoides R. Brown (Solanaceae) was synthesized, and the sulfate and hydrochloride salts were prepared. In addition, the H-1- and C-13-NMR spectral data is reported. Finally, the antimuscarinic potency of the synthesized sulfate of tropine nonanoate was compared to atropine sulfate in a radioligand binding assay. C1 HOWARD UNIV,COLL PHARM & PHARM SCI,DEPT MED CHEM,WASHINGTON,DC 20059. WALTER REED ARMY INST RES,DEPT APPL BIOCHEM,DIV BIOCHEM,WASHINGTON,DC 20307. NR 7 TC 1 Z9 1 U1 0 U2 0 PU SWETS ZEITLINGER BV PI LISSE PA P O BOX 825, 2160 SZ LISSE, NETHERLANDS SN 0925-1618 J9 INT J PHARMACOGN JI Int. J. Pharmacogn. PD MAR PY 1995 VL 33 IS 1 BP 78 EP 80 PG 3 WC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy SC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy GA TF517 UT WOS:A1995TF51700016 ER PT J AU RUSSELL, PK AF RUSSELL, PK TI HEADING OFF A CRISIS IN VACCINE DEVELOPMENT SO ISSUES IN SCIENCE AND TECHNOLOGY LA English DT Article C1 USA,MED RES & DEV COMMAND,WASHINGTON,DC 20310. RP RUSSELL, PK (reprint author), JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,615 N WOLFE ST,BALTIMORE,MD, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0748-5492 J9 ISSUES SCI TECHNOL JI Issues Sci. Technol. PD SPR PY 1995 VL 11 IS 3 BP 26 EP 32 PG 7 WC Engineering, Multidisciplinary; Engineering, Industrial; Multidisciplinary Sciences; Social Issues SC Engineering; Science & Technology - Other Topics; Social Issues GA QU009 UT WOS:A1995QU00900015 ER PT J AU HOGAN, DW AF HOGAN, DW TI PERILOUS OPTIONS - SPECIAL OPERATIONS AS AN INSTRUMENT OF UNITED-STATES-FOREIGN-POLICY - VANDENBROUCKE,LS SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review RP HOGAN, DW (reprint author), USA,CTR MIL HIST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ORGAN AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47401 SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD MAR PY 1995 VL 81 IS 4 BP 1824 EP 1825 DI 10.2307/2081841 PG 2 WC History SC History GA QP952 UT WOS:A1995QP95200241 ER PT J AU BOEHM, KA ROSS, PF AF BOEHM, KA ROSS, PF TI DETERMINATION OF TOTAL NITROGEN IN URINE BY PYROCHEMILUMINESCENCE - COLLABORATIVE STUDY SO JOURNAL OF AOAC INTERNATIONAL LA English DT Article ID BALANCE; NUTRITION AB Twelve collaborating laboratories analyzed 5 blind duplicate samples of human urine for total nitrogen using a pyrochemiluminescence method. The nitrogen content ranged from low (650 mg/L) to high levels (8800 mg/L) in urine samples of people under moderate to severe stress. In addition to test samples, collaborators also received a certified standard (sodium nitrite in water) as an external control. The pyrochemiluminescence assay was performed on urine samples diluted in water within a range of 1:50 to 1:100. The method detects total nitrogen by reaction of the product of high temperature oxidative pyrolysis and ozone. Repeatability standard deviation values (RDS(r)) ranged from 1.49 to 3.91% and reproducibility standard deviation values (RSD(R)) ranged from 3.66 to 9.57%. The average recovery of total nitrogen was 99.9%. The pyrochemiluminescence method for determination of total nitrogen in urine was adopted first action by AOAC INTERNATIONAL. C1 USDA,ANIM & PLANT HLTH INSPECT SERV,NATL VET SERV LABS,AMES,IA 50010. USA,INST SURG RES,CTR BURN,FT SAM HOUSTON,TX 78234. UNIV MICHIGAN,ANN ARBOR,MI 48109. UNIV TENNESSEE,CTR HLTH SCI,DEPT CLIN PHARM,MEMPHIS,TN 38163. SCI RES CONSORTIUM,ST PAUL,MN. DUKE UNIV,CRIT CARE DIAGNOST SERV,DURHAM,NC. UNIV ROCHESTER,SCH MED,DEPT SURG,ROCHESTER,NY. PENNINGTON BIOMED RES CTR,BATON ROUGE,LA. UNIV TENNESSEE,DEPT ANESTHESIOL RES,KNOXVILLE,TN. USDA ARS,HUMAN NUTR RES CTR,GRAND FORKS,ND 58202. MCGAW INC,DEPT MED,IRVINE,CA. UNIV WASHINGTON,HARBORVIEW MED CTR,DEPT LAB MED,SEATTLE,WA 98104. RP BOEHM, KA (reprint author), ANTEK INSTRUMENTS INC,DEPT MED & NUTR RES,300 BAMMEL WESTFIELD RD,HOUSTON,TX 77090, USA. NR 8 TC 5 Z9 5 U1 1 U2 4 PU AOAC INTERNATIONAL PI GAITHERSBURG PA 481 NORTH FREDRICK AVE, STE 500, GAITHERSBURG, MD 20877-2504 SN 1060-3271 J9 J AOAC INT JI J. AOAC Int. PD MAR-APR PY 1995 VL 78 IS 2 BP 301 EP 306 PG 6 WC Chemistry, Analytical; Food Science & Technology SC Chemistry; Food Science & Technology GA QN304 UT WOS:A1995QN30400005 PM 7756845 ER PT J AU POLI, MA REIN, KS BADEN, DG AF POLI, MA REIN, KS BADEN, DG TI RADIOIMMUNOASSAY FOR PBTX-2-TYPE BREVETOXINS - EPITOPE SPECIFICITY OF 2 ANTI-PBTX SERA SO JOURNAL OF AOAC INTERNATIONAL LA English DT Article; Proceedings Paper CT Symposium on Analytical Methods for Seafood Toxins, at the 107th AOAC International Annual Meeting CY JUL 26-29, 1993 CL WASHINGTON, DC SP ASSOC OFFICIAL ANALYT CHEMISTS ID RED TIDE DINOFLAGELLATE; PTYCHODISCUS-BREVIS; GYMNODINIUM; ANTIBODIES; TOXINS AB Antiserum against PbTx-2-type brevetoxins was produced by immunizing rabbits with a PbTx-2-bovine serum albumin (BSA) conjugate, This serum had a higher affinity, but lower titer, than our current goat serum, Using 4 natural brevetoxins and 6 synthetic derivatives as competitors in our brevetoxin radioimmunoassay, we determined the epitope specificity of both sera. Modification of the backbone structure at C-42 on the K-ring had little or no effect on the antigen-binding capability of either serum, Reduction of the double bond between C-2 and C-3 on the A-ring by reduction of the lactone decreased binding 500 to 750-fold. Epoxidation of the double bond between C-27 and C-28 on the H-ring did not affect binding, which suggested that the goat serum is specific for the A-ring region of the brevetoxin backbone, In contrast, modifying the A-ring had no effect on rabbit serum binding. However, epoxidation of the H-ring decreased binding 5 to 20-fold, which suggested that the rabbit antiserum is specific for the H-ring region of the molecule, These results suggest that assays utilizing only one antibody may not adequately detect toxin metabolites if molecules are altered in the critical region of antibody recognition. C1 UNIV MIAMI,ROSENSTIEL SCH MARINE & ATMOSPHER SCI,NIEHS,CTR MARINE & FRESHWATER BIOMED SCI,MIAMI,FL 33101. RP POLI, MA (reprint author), USA,MED RES INST INFECT DIS,FREDERICK,MD 21702, USA. NR 17 TC 35 Z9 36 U1 0 U2 0 PU AOAC INTERNATIONAL PI GAITHERSBURG PA 481 NORTH FREDRICK AVE, STE 500, GAITHERSBURG, MD 20877-2504 SN 1060-3271 J9 J AOAC INT JI J. AOAC Int. PD MAR-APR PY 1995 VL 78 IS 2 BP 538 EP 542 PG 5 WC Chemistry, Analytical; Food Science & Technology SC Chemistry; Food Science & Technology GA QN304 UT WOS:A1995QN30400044 PM 7538841 ER PT J AU BATRA, RC ZHANG, X WRIGHT, TW AF BATRA, RC ZHANG, X WRIGHT, TW TI CRITICAL STRAIN RANKING OF 12 MATERIALS IN DEFORMATIONS INVOLVING ADIABATIC SHEAR BANDS SO JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME LA English DT Note C1 USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005. RP BATRA, RC (reprint author), VIRGINIA POLYTECH INST & STATE UNIV,DEPT ENGN SCI & MECH,BLACKSBURG,VA 24061, USA. NR 8 TC 10 Z9 10 U1 0 U2 3 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0021-8936 J9 J APPL MECH-T ASME JI J. Appl. Mech.-Trans. ASME PD MAR PY 1995 VL 62 IS 1 BP 252 EP 255 DI 10.1115/1.2895918 PG 4 WC Mechanics SC Mechanics GA QR187 UT WOS:A1995QR18700043 ER PT J AU GRUBER, JB MORRISON, CA HARRIS, DC SELTZER, MD ALLIK, TH HUTCHINSON, JA SCRIPSICK, MP AF GRUBER, JB MORRISON, CA HARRIS, DC SELTZER, MD ALLIK, TH HUTCHINSON, JA SCRIPSICK, MP TI SPECTRA OF TETRAVALENT CHROMIUM IN CALCIUM FLUOROPHOSPHATE SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SPECTROSCOPIC PROPERTIES; FORSTERITE; LASER; IONS C1 USA,RES LAB,ADELPHI,MD 20783. USN,CTR AIR WARFARE,RES DEPT,DIV CHEM,CHINA LAKE,CA 93555. SCI APPLICAT INT CORP,MCLEAN,VA 22102. USA,NIGHT VIS & ELECTR SENSORS DIRECTORATE,FT BELVOIR,VA 22060. W VIRGINIA UNIV,DEPT PHYS,MORGANTOWN,WV 26505. RP GRUBER, JB (reprint author), SAN JOSE STATE UNIV,DEPT PHYS,SAN JOSE,CA 95192, USA. NR 37 TC 2 Z9 2 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAR 1 PY 1995 VL 77 IS 5 BP 2116 EP 2123 DI 10.1063/1.358787 PG 8 WC Physics, Applied SC Physics GA RC303 UT WOS:A1995RC30300048 ER PT J AU YOUNG, AJ SAWKA, MN LEVINE, L BURGOON, PW LATZKA, WA GONZALEZ, RR PANDOLF, KB AF YOUNG, AJ SAWKA, MN LEVINE, L BURGOON, PW LATZKA, WA GONZALEZ, RR PANDOLF, KB TI METABOLIC AND THERMAL ADAPTATIONS FROM ENDURANCE TRAINING IN HOT OR COLD-WATER SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE BLOOD LACTATE; BODY TEMPERATURE; ENERGY METABOLISM; MUSCLE GLYCOGEN; MUSCLE TEMPERATURE; PHYSICAL FITNESS ID MUSCLE BLOOD-FLOW; SKELETAL-MUSCLE; HEAT-STRESS; EXERCISE; HYPERTHERMIA; TEMPERATURE; TISSUES; HUMANS AB Metabolic and thermal adaptations resulting from endurance training in hot vs. cold water were compared. It was hypothesized that training in hot water would have greater effects on muscle glycogen use and blood lactate accumulation during exercise than training in cold water. Eighteen men exercised at 60% of maximal oxygen uptake while immersed in hot (n = 9) or cold water (n = 9) for 1 h, 5 days/wk, for 8 wk. Training in hot water (35 degrees C) potentiated body temperature increases during exercise, and training in cold water (20 degrees C) blunted body temperature increases during exercise. Before and after training, cardiorespiratory and thermoregulatory responses and muscle glycogen and blood lactate changes were assessed during a 1-h exercise trial in hot water and, on a separate day using the same intensity, in cold water. Oxygen uptake was similar for all trials, averaging 2.0 +/- 0.1 l/min. It was observed that 1) training reduced glycogen use and lactate accumulation during exercise, with no difference between cold and hot water training groups in the magnitude of this effect; 2) lactate accumulation during exercise was the same in hot water as in cold water; and 3) skin temperature decreased more rapidly during cold-water exercise after than before training, with no difference between cold and hot water training groups in the magnitude of this effect. Thus, exercise-induced body temperature increases are not an important stimulus for glycogen-sparing effects and blunted lactate accumulation associated with endurance training. RP YOUNG, AJ (reprint author), USA,ENVIRONM MED RES INST,DIV THERMAL PHYSIOL & MED,NATICK,MA 01760, USA. NR 29 TC 16 Z9 16 U1 2 U2 3 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD MAR PY 1995 VL 78 IS 3 BP 793 EP 801 PG 9 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA QP826 UT WOS:A1995QP82600007 PM 7775320 ER PT J AU KRAEMER, WJ PATTON, JF GORDON, SE HARMAN, EA DESCHENES, MR REYNOLDS, K NEWTON, RU TRIPLETT, NT DZIADOS, JE AF KRAEMER, WJ PATTON, JF GORDON, SE HARMAN, EA DESCHENES, MR REYNOLDS, K NEWTON, RU TRIPLETT, NT DZIADOS, JE TI COMPATIBILITY OF HIGH-INTENSITY STRENGTH AND ENDURANCE TRAINING ON HORMONAL AND SKELETAL-MUSCLE ADAPTATIONS SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE TESTOSTERONE; CORTISOL; ANAEROBIC POWER; MUSCLE FIBERS ID HEAVY-RESISTANCE EXERCISE; MYOFIBRILLAR ATPASE ACTIVITY; GROWTH-FACTOR RESPONSES; PLASMA BETA-ENDORPHIN; CONCURRENT STRENGTH; CHAIN COMPOSITION; MAXIMAL POWER; PROTOCOLS; VELOCITY; REGIMENS AB Thirty-five healthy men were matched and randomly assigned to one of four training groups that performed high-intensity strength and endurance training (C; n = 9), upper body only high-intensity strength and endurance training (UC; n = 9), high-intensity endurance training (E; n = 8), or high-intensity strength training (ST; n = 9). The C and ST groups significantly increased one-repetition maximum strength for all exercises (P < 0.05). Only the C, UC, and E groups demonstrated significant increases in treadmill maximal oxygen consumption. The ST group showed significant increases in power output. Hormonal responses to treadmill exercise demonstrated a differential response to the different training programs, indicating that the underlying physiological milieu differed with the training program. Significant changes in muscle fiber areas were as follows: types I, IIa, and IIc increased in the ST group; types I and IIc decreased in the E group; type IIa increased in the C group; and there were no changes in the UC group. Significant shifts in percentage from type IIb to type IIa were observed in all training groups, with the greatest shift in the groups in which resistance trained the thigh musculature. This investigation indicates that the combination of strength and endurance training results in an attenuation of the performance improvements and physiological adaptations typical of single-mode training. C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. RP KRAEMER, WJ (reprint author), PENN STATE UNIV,CTR SPORTS MED,146 REC BLDG,UNIVERSITY PK,PA 16802, USA. RI Enright, Kevin/A-5349-2011; Newton, Robert/A-3466-2009 OI Newton, Robert/0000-0003-0302-6129 NR 47 TC 413 Z9 427 U1 7 U2 74 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD MAR PY 1995 VL 78 IS 3 BP 976 EP 989 PG 14 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA QP826 UT WOS:A1995QP82600031 PM 7775344 ER PT J AU YOURICK, JJ DAWSON, JS MITCHELTREE, LW AF YOURICK, JJ DAWSON, JS MITCHELTREE, LW TI REDUCTION OF ERYTHEMA IN HAIRLESS GUINEA-PIGS AFTER CUTANEOUS SULFUR MUSTARD VAPOR EXPOSURE BY PRETREATMENT WITH NIACINAMIDE, PROMETHAZINE AND INDOMETHACIN SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE SULFUR MUSTARD; HAIRLESS GUINEA PIG; NIACINAMIDE; PROMETHAZINE; INDOMETHACIN ID 2,2'-DICHLORODIETHYL SULFIDE; PROSTAGLANDIN SYNTHESIS; TOPICAL INDOMETHACIN; NAD+ LEVELS; SKIN; PATHOGENESIS; NICOTINAMIDE; MECHANISM; SUNBURN; CULTURE AB Erythema is the initial symptom that occurs after sulfur mustard (HD) cutaneous exposure. The time course of HD-induced erythema is similar to that observed after UV irradiation, which can be reduced by indomethacin. Sulfur mustard lethality is decreased by using promethazine, which is an antihistamine. Niacinamide can reduce microvesication after HD vapor exposure in hairless guinea pig (HGP) skin. The present study examines the effect of the combined administration of niacinamide, indomethacin and promethazine used alone or in all possible combinations on the degree of erythema and histopathologic skin damage after HD exposure in HGP. Niacinamide (750 mg kg(-1), i.p.), promethazine (12.5 mg kg(-1), i.m,) or indomethacin (4 mg kg(-1), p.o.) used singly or in combination was given as a 30-min pretreatment before an 8-min HD vapor cup skin exposure. Using a combination pretreatment of niacinamide, promethazine and indomethacin, erythema was reduced at 4 (91%) and 6 (55%) h, but not 24 h after HD. The incidence of histopathological skin changes (microvesicles, follicular involvement, epidermal necrosis, intracellular edema and pustular epidermatitis) 24 h after HD was not reduced. This study indicates that HD-induced erythema may result from several different mechanisms, including inflammation, histamine release and DNA damage. It is suggested that two phases of inflammation may occur: an early phase sensitive to antihistamines and non-steroidal antiinflammatory drugs and a late phase of extensive cell damage that was not sensitive to these drug pretreatments. C1 USA,MED RES INST CHEM DEF,APPL PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. USA,MED RES INST CHEM DEF,COMPARAT PATHOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. NR 33 TC 31 Z9 31 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD MAR-APR PY 1995 VL 15 IS 2 BP 133 EP 138 DI 10.1002/jat.2550150213 PG 6 WC Toxicology SC Toxicology GA QP847 UT WOS:A1995QP84700011 PM 7782559 ER PT J AU KIM, HJ AF KIM, HJ TI INHIBITION OF ENZYMATIC BROWNING REACTION BY SULFITE SO JOURNAL OF CHEMICAL EDUCATION LA English DT Article C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. NR 6 TC 2 Z9 2 U1 1 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0021-9584 J9 J CHEM EDUC JI J. Chem. Educ. PD MAR PY 1995 VL 72 IS 3 BP 242 EP 243 PG 2 WC Chemistry, Multidisciplinary; Education, Scientific Disciplines SC Chemistry; Education & Educational Research GA QN887 UT WOS:A1995QN88700019 ER PT J AU TURNER, JF MASON, T ANDERSON, D GULATI, A SBARBARO, JA AF TURNER, JF MASON, T ANDERSON, D GULATI, A SBARBARO, JA TI PHYSICIANS ETHICAL RESPONSIBILITIES UNDER CO-PAY INSURANCE - SHOULD POTENTIAL FISCAL LIABILITY BECOME PART OF INFORMED CONSENT SO JOURNAL OF CLINICAL ETHICS LA English DT Article ID INTENSIVE-CARE; SURVIVAL C1 FITZSIMONS ARMY MED CTR,MED ICU,AURORA,CO. UNIV COLORADO,HLTH SCI CTR,COLORADO AIDS EDUC & TRAINING CTR,SEARCH AHEC PROGRAM,DENVER,CO 80262. UNIV COLORADO,PUBL HLTH PROGRAM,DENVER,CO 80202. UNIV COLORADO,HLTH SCI CTR,DEPT MED,HLTH POLICY & MED ETH SECT,DENVER,CO 80262. RP TURNER, JF (reprint author), USA,FITZSIMONS ARMY MED CTR,MED CORPS,DEPT MED,DIV PULM DIS & CRIT CARE,AURORA,CO, USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU UNIV PUBL GROUP, INC PI FREDERICK PA 12 SOUTH MARKET ST, STE 301, FREDERICK, MD 21701 SN 1046-7890 J9 J CLIN ETHIC JI J. Clin. Ethics PD SPR PY 1995 VL 6 IS 1 BP 68 EP 72 PG 5 WC Ethics; Social Sciences, Biomedical SC Social Sciences - Other Topics; Biomedical Social Sciences GA QX756 UT WOS:A1995QX75600010 PM 7632999 ER PT J AU KEPCZYK, T ANGUEIRA, CE KADAKIA, SC MILLER, G MELENSON, G AF KEPCZYK, T ANGUEIRA, CE KADAKIA, SC MILLER, G MELENSON, G TI CHOLEDOCHAL CYST MIMICKING A PANCREATIC PSEUDOCYST SO JOURNAL OF CLINICAL GASTROENTEROLOGY LA English DT Article DE PANCREATITIS; PANCREATIC PSEUDOCYST; CHOLEDOCHAL CYST; SUPPURATIVE CHOLANGITIS ID BILE-DUCT; CLASSIFICATION; MANAGEMENT; DILATATION; ADULT AB Choledochal cyst mimicking a pancreatic pseudocyst radiographically has not yet been reported. We report such a patient with a choledochal cyst whose initial presentation was acute pancreatitis. Ultrasound and computed tomography scan showed images that resembled a pancreatic pseudocyst. C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DEPT SURG,GEN SURG SERV,FT SAM HOUSTON,TX 78234. NR 12 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0192-0790 J9 J CLIN GASTROENTEROL JI J. Clin. Gastroenterol. PD MAR PY 1995 VL 20 IS 2 BP 139 EP 141 DI 10.1097/00004836-199503000-00014 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA QM502 UT WOS:A1995QM50200014 PM 7769195 ER PT J AU KADAKIA, SC AF KADAKIA, SC TI D-LACTIC ACIDOSIS IN A PATIENT WITH JEJUNOILEAL BYPASS SO JOURNAL OF CLINICAL GASTROENTEROLOGY LA English DT Article DE D-LACTIC ACIDOSIS; JEJUNOILEAL BYPASS ID SHORT-BOWEL SYNDROME; D-LACTATE; ENCEPHALOPATHY; METABOLISM AB D-Lactic acidosis is an unique complication of jejunoileal bypass occurring because of alteration of colonic bacterial flora with selective proliferation of D-lactate-producing bacteria. The D-lactate accumulation in the serum is associated with encephalopathy, which responds to oral antibiotic drugs in most patients. Because gastroenterologists may encounter such patients for some time to come, we report a new case and review the literature. C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,SAN ANTONIO,TX. NR 19 TC 14 Z9 14 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0192-0790 J9 J CLIN GASTROENTEROL JI J. Clin. Gastroenterol. PD MAR PY 1995 VL 20 IS 2 BP 154 EP 156 DI 10.1097/00004836-199503000-00019 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA QM502 UT WOS:A1995QM50200019 PM 7769200 ER PT J AU GRUNBERG, SM BURRIS, H LIVINGSTON, R AF GRUNBERG, SM BURRIS, H LIVINGSTON, R TI THE PRICE OF SUCCESS SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Letter ID SECONDARY LEUKEMIA; ETOPOSIDE; CANCER C1 BROOKE ARMY MED CTR,SAN ANTONIO,TX. UNIV WASHINGTON,SEATTLE,WA 98195. RP GRUNBERG, SM (reprint author), UNIV VERMONT,VERMONT CANC CTR,BURLINGTON,VT, USA. NR 7 TC 3 Z9 3 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAR PY 1995 VL 13 IS 3 BP 797 EP 798 PG 2 WC Oncology SC Oncology GA QL034 UT WOS:A1995QL03400040 PM 7884441 ER PT J AU SODHI, DS AF SODHI, DS TI BREAKTHROUGH LOADS OF FLOATING ICE SHEETS SO JOURNAL OF COLD REGIONS ENGINEERING LA English DT Article AB For safe transportation of loads on floating ice sheets, it is important to determine the breakthrough load of an ice sheet. At present, the breakthrough load is estimated using empirical relations developed from the results of full-scale field experiments. In this paper, a theoretical formulation is presented to derive an expression for the breakthrough load using plastic limit analysis. The velocity field in the vicinity of a distributed load is assumed, and the stresses induced in the columnar ice are assumed to be the biaxial strength, which depends on the strain rate derived form assumed velocity field. The breakthrough load is obtained by equating the rate of work done by the load to the rate of energy dissipation during compression of ice caused by radial and circumferential wedging of ice during deformation. The agreement between the theoretical estimates and the experimental breakthrough loads is good when energy dissipation due to radical deformation along circumferential cracks is ignored. The theoretical estimates of breakthrough loads are about twice the experimental loads when the radial crushing strength along circumferential cracks is assumed to be 1 MPa. Shear or punching failure due to concentrated load on a floating ice sheet is also briefly discussed. RP SODHI, DS (reprint author), USA,CORPS ENGINEERS,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 29 TC 15 Z9 15 U1 0 U2 2 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0887-381X J9 J COLD REG ENG JI J. Cold Reg. Eng. PD MAR PY 1995 VL 9 IS 1 BP 4 EP 22 DI 10.1061/(ASCE)0887-381X(1995)9:1(4) PG 19 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA RP457 UT WOS:A1995RP45700002 ER PT J AU DALY, SF AF DALY, SF TI FRACTURE OF RIVER ICE COVERS BY RIVER WAVES SO JOURNAL OF COLD REGIONS ENGINEERING LA English DT Article ID BREAKUP AB The stresses induced in ice covers by river waves are investigated as a possible mechanism for causing transverse cracks during breakup. The maximum stress levels that river waves can cause in the ice cover are determined over the entire spectrum of waves that may be present at breakup. The ice cover is analyzed as a continuous elastic plate. For a given wave amplitude, the amplitude of ice covers bending stress has two possible maximums: one when the wavelength is equal to 2 pi/ (where l is the characteristic length of the ice cover), and a second when the celerity of the propagating wave equals the celerity of a free (homogeneous) wave of the same wavelength. The present calculations indicate that the celerities of propagating waves are always less than the celerity of free waves of the same wavelength, and, as a result, only the first maximum is possible. The global minimum wave amplitude required to cause cracks is therefore found at a wavelength of 2 pi/. At this wavelength, a simple expression describing the minimum wave amplitude causing cracks can be derived. RP DALY, SF (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 25 TC 13 Z9 14 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0887-381X J9 J COLD REG ENG JI J. Cold Reg. Eng. PD MAR PY 1995 VL 9 IS 1 BP 41 EP 52 DI 10.1061/(ASCE)0887-381X(1995)9:1(41) PG 12 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA RP457 UT WOS:A1995RP45700004 ER PT J AU JERANT, AF AF JERANT, AF TI TERAZOSIN FOR BPH SO JOURNAL OF FAMILY PRACTICE LA English DT Letter RP JERANT, AF (reprint author), EISENHOWER ARMY MED CTR,FT GORDON,GA 30905, USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU APPLETON & LANGE PI E NORWALK PA 25 VAN ZANT ST, E NORWALK, CT 06855 SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD MAR PY 1995 VL 40 IS 3 BP 222 EP 222 PG 1 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA QL852 UT WOS:A1995QL85200001 PM 7533204 ER PT J AU BUEHLER, DA FRASER, JD FULLER, MR MCALLISTER, LS SEEGAR, JKD AF BUEHLER, DA FRASER, JD FULLER, MR MCALLISTER, LS SEEGAR, JKD TI CAPTIVE AND FIELD-TESTED RADIO TRANSMITTER ATTACHMENTS FOR BALD EAGLES SO JOURNAL OF FIELD ORNITHOLOGY LA English DT Article ID CHESAPEAKE BAY; LOAD AB The effects of two radio transmitter attachment techniques on captive and one attachment technique on wild Bald Eagles (Habiaeetus leucocephalus) were studied. A Y-attachment method with a 160-g dummy transmitter was less apt to cause tissue damage on captive birds than an X-attachment method, and loosely fit transmitters caused less damage than tightly fit transmitters. Annual survival of wild birds fitted with 65-g transmitters via an X attachment was estimated at 90-95%. As a result of high survival, only five wild birds marked as nestlings were recovered. Two of these birds had superficial pressure sores from tight-fitting harnesses. It is recommended that a 1.3-cm space be left between the transmitter and the bird's back when radio-tagging post-fledging Bald Eagles. Additional space, perhaps up to 2.5 cm, is required for nestlings to anew for added growth and development. C1 VIRGINIA POLYTECH INST & STATE UNIV,DEPT FISHERIES & WILDLIFE SCI,BLACKSBURG,VA 24061. US FISH & WILDLIFE SERV,PATUXENT WILDLIFE RES CTR,LAUREL,MD 20708. USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 22 TC 51 Z9 53 U1 0 U2 6 PU ASSOC FIELD ORNITHOLOGISTS PI BELOIT PA BELOIT COLLEGE, DEPT BIOLOGY, 700 COLLEGE ST, BELOIT, WI 53511 SN 0273-8570 J9 J FIELD ORNITHOL JI J. Field Ornithol. PD SPR PY 1995 VL 66 IS 2 BP 173 EP 180 PG 8 WC Ornithology SC Zoology GA QV969 UT WOS:A1995QV96900001 ER PT J AU TAYLOR, MS ZOLTANI, CK AF TAYLOR, MS ZOLTANI, CK TI METAANALYSIS OF GAS-FLOW RESISTANCE MEASUREMENTS THROUGH PACKED-BEDS SO JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME LA English DT Article AB Measurements of the resistance to flow through packed beds of inert spheres have been reported by a number of authors through relations expressing the coefficient of drag as a function of Reynolds number. A meta-analysis of the data using improved statistical methods is undertaken to aggregate the available experimental results. For Reynolds number in excess of Id the relation log F-v = 0.49 + 0.90 log Re' is shown to be a highly effective representation of all available data. RP TAYLOR, MS (reprint author), USA,RES LAB,DEPT ARMY,ABERDEEN PROVING GROUND,MD 21005, USA. NR 16 TC 0 Z9 0 U1 0 U2 1 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0098-2202 J9 J FLUID ENG-T ASME JI J. Fluids Eng.-Trans. ASME PD MAR PY 1995 VL 117 IS 1 BP 176 EP 180 DI 10.1115/1.2816808 PG 5 WC Engineering, Mechanical SC Engineering GA QP809 UT WOS:A1995QP80900031 ER PT J AU MORYAN, D AF MORYAN, D TI USING THE VIDEO SPECTRAL COMPARATOR IN THE COMPARISON OF CARBON COPIES AND CARBON PAPER IMPRESSIONS SO JOURNAL OF FORENSIC SCIENCES LA English DT Note DE QUESTIONED DOCUMENTS; CARBON PAPER; VIDEO SPECTRAL COMPARATOR AB Provided with overwritten carbon paper images and one carbon copied document produced by the carbon paper, decipherment of the overwritten entries can be made. A technique using the Video Spectral Comparator with the Image Integration Comparator can reveal overwritten entries by storing and superimposing images of the carbon paper and carbon copied document. RP MORYAN, D (reprint author), USA,CRIMINAL INVEST LAB,DIV QUESTIONED DOCUMENT,FT GILLEM,GA 30050, USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD MAR PY 1995 VL 40 IS 2 BP 296 EP 299 PG 4 WC Medicine, Legal SC Legal Medicine GA QN285 UT WOS:A1995QN28500029 ER PT J AU ENGHARDT, MH AGHASSI, NB BOND, CJ ELSTON, DM AF ENGHARDT, MH AGHASSI, NB BOND, CJ ELSTON, DM TI A SIMPLIFIED MULTITISSUE CONTROL BLOCK SO JOURNAL OF HISTOTECHNOLOGY LA English DT Article DE IMMUNOHISTOCHEMISTRY; MULTITISSUE CONTROL; MULTITISSUE CORE BLOCK; QUALITY CONTROL ID TISSUE BLOCK AB A modification of the multitissue control for immunohistochemistry is described. The multitissue core block (MTCB) was made by extracting rods of paraffin embedded tissue from existing blocks and inserting them according to a predefined pattern into a blank paraffin block. The rods were sealed into place with heat. The procedure is simple and requires no complex equipment. The result is a structured multitissue control that can be prepared facilely and quickly. Archived blocks can be used as a source of control tissue without destructive sampling. This concept was successfully tested with an automated immunohistochemical staining system. C1 BIOGENEX CORP,SAN RAMON,CA. RP ENGHARDT, MH (reprint author), BROOKE ARMY MED CTR,DEPT PATHOL & DERMATOL,FT SAM HOUSTON,TX 78234, USA. NR 9 TC 2 Z9 2 U1 0 U2 0 PU NATL SOC HISTOTECHNOLOGY PI BOWIE PA 4201 NORTHVIEW DR, STE 502, BOWIE, MD 20716-1073 SN 0147-8885 J9 J HISTOTECHNOL JI J. Histotechnol. PD MAR PY 1995 VL 18 IS 1 BP 51 EP 55 PG 5 WC Cell Biology SC Cell Biology GA QY296 UT WOS:A1995QY29600009 ER PT J AU BRODINE, SK HYAMS, KC MOLGAARD, CA ITO, SI THOMAS, RJ ROBERTS, CR GOLBECK, AL OLDFIELD, EC BLATTNER, WA AF BRODINE, SK HYAMS, KC MOLGAARD, CA ITO, SI THOMAS, RJ ROBERTS, CR GOLBECK, AL OLDFIELD, EC BLATTNER, WA TI THE RISK OF HUMAN T-CELL LEUKEMIA-VIRUS AND VIRAL-HEPATITIS INFECTION AMONG US MARINES STATIONED IN OKINAWA, JAPAN SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note ID UNITED-STATES-NAVY; SEXUAL TRANSMISSION; MILITARY PERSONNEL; DISEASES; ANTIBODY AB The prevalence and incidence of human T cell leukemia virus type I/II (HTLV-I/II) and hepatitis A, B, and C virus infection were determined among US Marines stationed in Okinawa, Japan. Of 2875 personnel, 2 (0.07%) had antibody to HTLV-I/II. After 1-3 years, no HTLV seroconversions were observed, although 23% reported sexual contact with Okinawans. Of 1010 hepatitis-tested marines, 121 (12%) had antibody to hepatitis A virus (anti-HAV), 26 (2.6%) had antibody to hepatitis B core antigen (anti-HBc), and 2 (0.2%) had antibody to hepatitis C virus (anti-HCV). On follow-up, 1 subject seroconverted to anti-HAV, 8 to anti-HBc, and none to anti-HCV. Most marines with recent hepatitis B infection were young, single, and enlisted and had been on short deployments to other countries in Southeast Asia. Marines stationed in Okinawa are not at high risk for HTLV infection but are at increased risk for hepatitis B infection and should be considered for vaccination. C1 USN,MED CTR,DEPT INTERNAL MED,DIV INFECT DIS,SAN DIEGO,CA 92152. NCI,NAVAL MED RES INST,DIV EPIDEMIOL,BETHESDA,MD. NCI,VIRAL EPIDEMIOL SECT,BETHESDA,MD. NAVAL HOSP OKINAWA,DEPT PREVENT MED,MARINE EXPEDITIONARY FORCE 3,OKINAWA,JAPAN. WALTER REED ARMY INST RES,DIV RETROVIROL,WASHINGTON,DC. RP BRODINE, SK (reprint author), SAN DIEGO STATE UNIV,NAVAL HLTH RES CTR,GRAD SCH PUBL HLTH,DEPT MATH SCI,SAN DIEGO,CA 92186, USA. NR 17 TC 5 Z9 6 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAR PY 1995 VL 171 IS 3 BP 693 EP 696 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA QJ455 UT WOS:A1995QJ45500028 PM 7876620 ER PT J AU NUZUM, E WHITE, F THAKUR, C DIETZE, R WAGES, J GROGL, M BERMAN, J AF NUZUM, E WHITE, F THAKUR, C DIETZE, R WAGES, J GROGL, M BERMAN, J TI DIAGNOSIS OF SYMPTOMATIC VISCERAL LEISHMANIASIS BY USE OF THE POLYMERASE CHAIN-REACTION ON PATIENT BLOOD SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note ID KINETOPLAST DNA; KALA-AZAR; SODIUM STIBOGLUCONATE; AMPLIFICATION; HYBRIDIZATION; MINICIRCLES; REGIONS AB To diagnose symptomatic visceral leishmaniasis (kala-azar) using peripheral blood rather than tissue aspirates, a polymerase chain reaction (PCR) technique was developed for which the detection limit is 1 Leishmania-infected macrophage in 8 mL of blood. For Indian, Kenyan, or Brazilian patients with parasitologically confirmed kala-azar, 57 of 63 cases before treatment had blood that was PCR-positive (90% sensitivity). None of 40 clinically healthy persons had PCR-positive blood (100% specificity). Twelve (92%) of 13 clinically cured Indian patients had negative PCR reactions 1-6 months after treatment. This PCR procedure can provide a parasitologic diagnosis for the vast majority of kala-azar cases before therapy, may identify patients who have been successfully treated by chemotherapy, and should substantially reduce the need for invasive tests. C1 SRA TECHNOL INC,ROCKVILLE,MD. PATNA MED COLL,PATNA,BIHAR,INDIA. FED UNIV ESPIRITO SANTO,VITORIA,ES,BRAZIL. RP NUZUM, E (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 13 TC 66 Z9 70 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAR PY 1995 VL 171 IS 3 BP 751 EP 754 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA QJ455 UT WOS:A1995QJ45500043 PM 7876635 ER PT J AU DEFRAITES, RF FEIGHNER, BH BINN, LN KANJARPANE, DD DELEM, AD MACARTHY, PO KRAUSS, MR KRAUSE, DS MOONSAMMY, GI HOKE, CH AF DEFRAITES, RF FEIGHNER, BH BINN, LN KANJARPANE, DD DELEM, AD MACARTHY, PO KRAUSS, MR KRAUSE, DS MOONSAMMY, GI HOKE, CH TI IMMUNIZATION OF US SOLDIERS WITH A 2-DOSE PRIMARY SERIES OF INACTIVATED HEPATITIS-A VACCINE - EARLY IMMUNE-RESPONSE, PERSISTENCE OF ANTIBODY, AND RESPONSE TO A 3RD DOSE AT 1 YEAR SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT Meeting on Overview of the Clinical Development of Hepatitis A Vaccine CY FEB 03-06, 1994 CL MARCO ISLAND, FL ID A VIRUS; TRAVELERS; VIROLOGY AB To study the feasibility of using inactivated hepatitis A vaccine for rapid immunization of US soldiers, 276 randomized seronegative volunteers received one of four regimens: two injections, on day 0 or one each on day 0 and 14, day 0 and 30, or day 0 and 180. A third dose was given on day 380, Among the 256 recipients of two doses, 99% responded with antibody (by ELISA) with few symptoms. A higher percentage of recipients of both doses on day 0 had antibody at day 14 (68% vs. 52% of all others, P < .03), The highest antibody concentrations (711 mIU/mL on day 240) were observed in subjects given a second dose on day 180. Recipients of the third injection developed a median 15-fold rise in antibody within 2 weeks. Virus-neutralizing antibody was detected in high titers after the third dose and neutralized strains of hepatitis A virus from several countries. Vaccines containing 1440 ELISA units of antigen may be useful for rapid immunization. C1 SMITHKLINE BEECHAM BIOL,RIXENSART,BELGIUM. MADIGAN ARMY MED CTR,FT LEWIS,WA. SMITHKLINE BEECHAM PHARMACEUT,KING OF PRUSSIA,PA. RP DEFRAITES, RF (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT FIELD STUDIES,WASHINGTON,DC 20307, USA. NR 28 TC 3 Z9 3 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAR PY 1995 VL 171 SU 1 BP S61 EP S69 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA QK826 UT WOS:A1995QK82600013 PM 7876651 ER PT J AU HOKE, CH EGAN, JE SJOGREN, MH SANCHEZ, J DEFRAITES, RF MACARTHY, PO BINN, LN RICE, R BURKE, A HILL, J KIMES, MH ERIKSON, L BOSCIA, J MOONSAMMY, GI DHONDT, E BANCROFT, WH AF HOKE, CH EGAN, JE SJOGREN, MH SANCHEZ, J DEFRAITES, RF MACARTHY, PO BINN, LN RICE, R BURKE, A HILL, J KIMES, MH ERIKSON, L BOSCIA, J MOONSAMMY, GI DHONDT, E BANCROFT, WH TI ADMINISTRATION OF HEPATITIS-A VACCINE TO A MILITARY POPULATION BY NEEDLE AND JET INJECTOR AND WITH HEPATITIS-B VACCINE SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT Meeting on Overview of the Clinical Development of Hepatitis A Vaccine CY FEB 03-06, 1994 CL MARCO ISLAND, FL ID A VIRUS-VACCINE; CELL-CULTURES; IMMUNOGENICITY; ORIGIN AB Military personnel are an important target population for hepatitis A immunization. Soldiers are often given vaccines by jet injector and may be required to receive multiple vaccines at one time. Formalin-inactivated hepatitis A vaccine containing 360 ELISA units of antigen was evaluated at Fort Campbell. Volunteers received vaccine at 0, 1, and 6 months as follows: group 1, hepatitis A vaccine by needle; group 2, hepatitis A vaccine by jet injector; group 3, hepatitis B vaccine by needle; and group 4, both hepatitis vaccines by needle in separate arms. Immune response and reactogenicity were evaluated. After two doses, recipients of vaccine administered by jet injector had a higher prevalence of antibody than those who received vaccine by needle (93% vs, 79%). By the 8th month, the vaccine was 100% immunogenic by either route or with hepatitis B vaccine. No interaction between hepatitis A and B vaccines was detected. C1 FT CAMPBELL,FT CAMPBELL,KY. USA,MED MAT DEV ACTIV,FT DETRICK,MD. SMITHKLINE BEECHAM PHARMACEUT,CONSHOHOCKEN,PA. RP HOKE, CH (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT VIRUS DIS,WASHINGTON,DC 20307, USA. NR 21 TC 18 Z9 18 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAR PY 1995 VL 171 SU 1 BP S53 EP S60 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA QK826 UT WOS:A1995QK82600012 PM 7876650 ER PT J AU WAGER, SJ SCHULZ, DE AF WAGER, SJ SCHULZ, DE TI CIVIL-MILITARY RELATIONS IN MEXICO - THE ZAPATISTA REVOLT AND ITS IMPLICATIONS SO JOURNAL OF INTERAMERICAN STUDIES AND WORLD AFFAIRS LA English DT Article C1 USA,COLL WAR,INST STRATEG STUDIES,WASHINGTON,DC 20310. RP WAGER, SJ (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 64 TC 4 Z9 4 U1 0 U2 1 PU UNIV MIAMI PI CORAL GABLES PA J INTERAMER STUD WORLD AFF PO BOX 248134, CORAL GABLES, FL 33124 SN 0022-1937 J9 J INTERAM STUD WORLD JI J. Interam. Stud. World Aff. PD SPR PY 1995 VL 37 IS 1 BP 1 EP 42 DI 10.2307/166215 PG 42 WC Area Studies; International Relations; Political Science SC Area Studies; International Relations; Government & Law GA RG109 UT WOS:A1995RG10900001 ER PT J AU JONES, AP WEBB, LMC ANDERSON, AO LEONARD, EJ ROT, A AF JONES, AP WEBB, LMC ANDERSON, AO LEONARD, EJ ROT, A TI NORMAL HUMAN SWEAT CONTAINS INTERLEUKIN-8 SO JOURNAL OF LEUKOCYTE BIOLOGY LA English DT Article DE CHEMOKINES; CHEMOTAXIS; LEUKOCYTES; MCP-1 ID RECEPTOR; CELLS; SPECIFICITY; CHEMOTAXIS; BINDING AB Sweating in humans is induced by physical or emotional stress, which raises the possibility that sweating may relate to host defense. We therefore asked whether human eccrine sweat attracts leukocytes and found that it is chemotactic for human neutrophils. This activity was due to several chemoattractants, one of which was interleukin-8 (IL-8). Using immunohistochemistry and in situ hybridization IL-8 and its mRNA have been detected in sweat gland epithelium, indicating that IL-8 is produced in situ. This establishes a pattern of physiological IL-8 secretion by exocrine glands and suggests that, in addition to its role as a major inflammatory mediator, IL-8 also has physiological homeostatic flunctions. C1 SANDOZ GMBH,FORSCHUNGSINST DERMATOL,A-1235 VIENNA,AUSTRIA. USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702. NCI,FREDERICK CANC RES & DEV CTR,FREDERICK,MD 21702. NR 24 TC 24 Z9 24 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0741-5400 J9 J LEUKOCYTE BIOL JI J. Leukoc. Biol. PD MAR PY 1995 VL 57 IS 3 BP 434 EP 437 PG 4 WC Cell Biology; Hematology; Immunology SC Cell Biology; Hematology; Immunology GA QM410 UT WOS:A1995QM41000013 PM 7884315 ER PT J AU KRAKAUER, T AF KRAKAUER, T TI DIFFERENTIAL INHIBITORY EFFECTS OF INTERLEUKIN-10, INTERLEUKIN-4, AND DEXAMETHASONE ON STAPHYLOCOCCAL ENTEROTOXIN-INDUCED CYTOKINE PRODUCTION AND T-CELL ACTIVATION SO JOURNAL OF LEUKOCYTE BIOLOGY LA English DT Article DE SUPERANTIGEN; TH1 TH2 CYTOKINES ID HUMAN-MONOCYTES; IL-10; PROLIFERATION; TOXICITY; RELEASE; CLONES; GAMMA; MICE AB The cytokine profile of human peripheral blood mononuclear cells (PBMC) stimulated by staphylococcal enterotoxin (SE) A and B was examined. Production of tumor necrosis factor (TNF alpha), interleukin (IL)-1, IL-6, IL-2, and gamma interferon (IFN-gamma) was observed. In contrast, Th2 cytokines IL-4 and IL-10 were absent from SEA- or SEE-stimulated PBMC, Moreover, adding IL-10 to SE-stimulated PBMC inhibited the production of IL-1, IL-6, TNF alpha, and IFN gamma by 50 to 80% but had less effect (8-30%) on T cell proliferation, IL-4 was less effective than IL-10 in inhibiting cytokine production and enhanced T cell proliferation by SEA or SEE. The antiinflammatory agent, dexamethasone, was the most potent agent in controlling the SE-mediated effects as evidenced by inhibited T cell proliferation (55%) and reduced levels of IL-1, IL-6, and IFN gamma (60% to 100%) and TNF alpha (50%), Reducing levels of toxic mediators such as TNF alpha, IL-1, IL-6, and IFN gamma by dexamethasone in SE-induced T cell responses may be a useful therapeutic strategy to circumvent SE toxicity and pathogenesis. RP KRAKAUER, T (reprint author), USA,MED RES INST INFECT DIS,DIV APPL RES,BLDG 1425,FREDERICK,MD 21702, USA. NR 26 TC 32 Z9 35 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0741-5400 J9 J LEUKOCYTE BIOL JI J. Leukoc. Biol. PD MAR PY 1995 VL 57 IS 3 BP 450 EP 454 PG 5 WC Cell Biology; Hematology; Immunology SC Cell Biology; Hematology; Immunology GA QM410 UT WOS:A1995QM41000016 PM 7884317 ER PT J AU MESSIER, DR PATEL, PJ AF MESSIER, DR PATEL, PJ TI HIGH-MODULUS GLASS-FIBERS SO JOURNAL OF NON-CRYSTALLINE SOLIDS LA English DT Article ID AL-O-N; NA2O-CAO-SIO2 GLASSES; OXYNITRIDE GLASSES; NITROGEN AB As compared with competing materials, glass fibers offer high stiffness as well as high tensile and compressive strengths at substantial cost advantages. That, in addition to their lack of flammability, and low toxicity when heated, make them attractive for use as reinforcements in advanced composites. Requirements for improved glass fibers for composites are reviewed, and the suitability of existing and developmental fibers for meeting those requirements is discussed. While oxynitride glasses are shown to be promising candidate materials for forming high-elastic-modulus glass fibers, tensile strengths are still below the strengths of the best oxide glass fibers. It is proposed that Si-rich metallic defects limit oxynitride glass fiber strength, and the origins of, and possible means of minimizing or eliminating the defects are discussed. RP MESSIER, DR (reprint author), USA,RES LAB,MAT DIRECTORATE,ARSENAL ST,WATERTOWN,MA 02172, USA. NR 28 TC 12 Z9 12 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-3093 J9 J NON-CRYST SOLIDS JI J. Non-Cryst. Solids PD MAR PY 1995 VL 182 IS 3 BP 271 EP 277 DI 10.1016/0022-3093(94)00520-6 PG 7 WC Materials Science, Ceramics; Materials Science, Multidisciplinary SC Materials Science GA QK778 UT WOS:A1995QK77800006 ER PT J AU MYATT, G BAXTER, R DOUGHERTY, R WILLIAMS, G HALLE, J STETTS, D UNDERWOOD, F AF MYATT, G BAXTER, R DOUGHERTY, R WILLIAMS, G HALLE, J STETTS, D UNDERWOOD, F TI THE CARDIOPULMONARY COST OF BACKWARD WALKING AT SELECTED SPEEDS SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE GAIT; OXYGEN CONSUMPTION; KNEE INJURIES AB Backward walking has been advocated as a method of maintaining cardiovascular conditioning in patients undergoing knee rehabilitation because it may decrease patellofemoral joint compressive forces. The primary purpose of this study was to determine the relationship between the rate of oxygen consumption (VO2) and backward walking speed. Twenty-five healthy males, aged 18-35 years, participated in this study. The rate of oxygen consumption and heart rate were measured at the backward walking speeds of 0.89, 1.12, 1.34, 1.56, and 1.79 m/sec (2.0, 2.5, 3.0, 3.5, and 4.0 miles/hour, respectively). Analysis revealed a direct, curvilinear relationship between VO2 and backward walking speed. This research provides information that can be used to prescribe a backward walking rehabilitation program which may be appropriate to maintain aerobic fitness levels during rehabilitation of patients with patellofemoral pain syndrome. C1 USA,BAYLOR UNIV,GRAD PROGRAM PHYS THERAPY,FT SAM HOUSTON,TX. NR 0 TC 26 Z9 28 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD MAR PY 1995 VL 21 IS 3 BP 132 EP 138 PG 7 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA QK190 UT WOS:A1995QK19000002 PM 7742838 ER PT J AU FINGER, DR BERNET, VJ DOYLE, JJ AF FINGER, DR BERNET, VJ DOYLE, JJ TI POLYGLANDULAR AUTOIMMUNE ENDOCRINOPATHY FOLLOWING PROCAINAMIDE INDUCED LUPUS SO JOURNAL OF RHEUMATOLOGY LA English DT Letter ID ADDISONS-DISEASE; ANTIBODIES C1 LANDSTUHL ARMY MED CTR,LANDSTUHL,GERMANY. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP FINGER, DR (reprint author), WILLIAM BEAUMONT ARMY MED CTR,EL PASO,TX 79920, USA. NR 8 TC 1 Z9 1 U1 0 U2 0 PU J RHEUMATOL PUBL CO PI TORONTO PA 920 YONGE ST, SUITE 115, TORONTO ON M4W 3C7, CANADA SN 0315-162X J9 J RHEUMATOL JI J. Rheumatol. PD MAR PY 1995 VL 22 IS 3 BP 574 EP 575 PG 2 WC Rheumatology SC Rheumatology GA QP817 UT WOS:A1995QP81700051 PM 7783091 ER PT J AU HARTUNG, GH AF HARTUNG, GH TI PHYSICAL-ACTIVITY AND HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL SO JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS LA English DT Editorial Material RP HARTUNG, GH (reprint author), TRIPLER ARMY MED CTR,DEPT MED,DMC,MCHK,SERV CARDIOL,HONOLULU,HI 96859, USA. NR 0 TC 7 Z9 8 U1 0 U2 0 PU EDIZIONI MINERVA MEDICA PI TURIN PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY SN 0022-4707 J9 J SPORT MED PHYS FIT JI J. Sports Med. Phys. Fit. PD MAR PY 1995 VL 35 IS 1 BP 1 EP 5 PG 5 WC Sport Sciences SC Sport Sciences GA RP453 UT WOS:A1995RP45300001 PM 7474986 ER PT J AU ELSTON, DM MCCOLLOUGH, ML ANGELONI, VL AF ELSTON, DM MCCOLLOUGH, ML ANGELONI, VL TI VERTICAL AND TRANSVERSE SECTIONS OF ALOPECIA BIOPSY SPECIMENS COMBINING THE 2 TO MAXIMIZE DIAGNOSTIC YIELD SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID ANATOMY; SCALP AB Background: Traditional vertical sections of scalp biopsy specimens contain few hair follicles. For this reason transverse sections of scalp biopsy specimens have been advocated. Both methods have advantages and disadvantages. We have developed a simple method that we believe offers the best of both methods. Objective: Our purpose was to assess the impact of combining vertical and transverse sections of scalp biopsy specimens. Methods: Two 4 mm punch biopsies are performed. One specimen is bisected vertically: half for hematoxylin-eosin (H-E) staining, half for direct immunofluorescence. The second specimen is bisected transversely and submitted for H-E. The three pieces of tissue for H-E staining are embedded in a single cassette. Results: Because a biopsy specimen for direct immunofluorescence is commonly obtained in cases of alopecia, our method does not add a surgical procedure. All three pieces of tissue for H-E staining are embedded in a single paraffin block. Therefore the cost of histologic interpretation is not increased. Our diagnostic yield improved. Transverse sections were superior in cases of lupus erythematosus and lichen planopilaris with focal follicular involvement. Features of the follicular degeneration syndrome were also best demonstrated in transverse sections. Interface changes, lupus panniculitis, miniaturized hairs, and trichomalacia were better demonstrated in vertical sections. Conclusion: Our method exploits the advantages of both vertical and transverse sections and improves diagnostic yield without increasing cost. C1 BROOKE ARMY MED CTR,DEPT PATHOL,FT SAM HOUSTON,TX 78234. RP ELSTON, DM (reprint author), BROOKE ARMY MED CTR,DERMATOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 9 TC 38 Z9 40 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD MAR PY 1995 VL 32 IS 3 BP 454 EP 457 DI 10.1016/0190-9622(95)90068-3 PG 4 WC Dermatology SC Dermatology GA QJ458 UT WOS:A1995QJ45800007 PM 7868715 ER PT J AU SAMLASKA, CP AF SAMLASKA, CP TI PENTOXIFYLLINE FOR SWEETS-SYNDROME - REPLY SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Letter RP SAMLASKA, CP (reprint author), TRIPLER ARMY MED CTR,DEPT ARMY,DERMATOL SERV,HONOLULU,HI 96859, USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD MAR PY 1995 VL 32 IS 3 BP 534 EP 535 DI 10.1016/0190-9622(95)90110-8 PG 2 WC Dermatology SC Dermatology GA QJ458 UT WOS:A1995QJ45800037 ER PT J AU GRABSKI, WJ GIANDONI, MB AF GRABSKI, WJ GIANDONI, MB TI DERMAL SUTURING TECHNIQUE - REPLY SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Letter C1 WILLIAM BEAUMONT ARMY MED CTR,DERMATOL SERV,EL PASO,TX 79920. RP GRABSKI, WJ (reprint author), BROOKE ARMY MED CTR,SAN ANTONIO,TX 78234, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD MAR PY 1995 VL 32 IS 3 BP 535 EP 535 DI 10.1016/0190-9622(95)90112-4 PG 1 WC Dermatology SC Dermatology GA QJ458 UT WOS:A1995QJ45800039 ER PT J AU KELEMEN, JJ CIOFFI, WG MCMANUS, WF MASON, AD PRUITT, BA AF KELEMEN, JJ CIOFFI, WG MCMANUS, WF MASON, AD PRUITT, BA TI BURN CENTER CARE FOR PATIENTS WITH TOXIC EPIDERMAL NECROLYSIS SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Article ID LANGERHANS CELLS; MANAGEMENT AB BACKGROUND: Toxic epidermal necrolysis (TEN) is a life threatening exfoliative disorder that is most commonly precipitated by the administration of a medication. Efforts to reduce morbidity and improve survival have brought into question the use of corticosteroids and recommend the transfer of patients to a burn center to facilitate wound care. STUDY DESIGN: This study evaluated the correlation of measures of disease severity and impact of treatment strategies on morbidity and mortality in patients with TEN. The records of all patients with TEN admitted to the United States Army Institute of Surgical Research. during a 12 year period were reviewed. Patient characteristics, etiologic agents, time to referral of patients to the burn center, corticosteroid therapy, and other demographic features were studied. Univariate and multivariate analyses were used to determine the significance of these factors with respect to outcome. RESULTS: The sulfonamides and phenytoin were the most frequently identified etiologic agents. Patients at the extremes of age had a higher mortality rate, The period of hospitalization was longer in patients transferred to the burn center more than seven days after skin slough, Percent of epidermalysis, white blood cell count nadir, and corticosteroid administration for more than 48 hours were independently associated with mortality. CONCLUSIONS: These data indicate that the sulfonamides and phenytoin are the most common etiologic agents, expeditious transfer to a burn center reduces morbidity, and corticosteroid administration dramatically increases mortality. C1 BROOKE ARMY MED CTR,DEPT GEN SURG,FT SAM HOUSTON,TX 78234. RP KELEMEN, JJ (reprint author), USA,INST SURG RES,2332 HARNEY RD,BLDG 2653,FT SAM HOUSTON,TX 78234, USA. NR 27 TC 90 Z9 91 U1 0 U2 1 PU AMER COLL SURGEONS PI CHICAGO PA 54 EAST ERIE ST, CHICAGO, IL 60611 SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD MAR PY 1995 VL 180 IS 3 BP 273 EP 278 PG 6 WC Surgery SC Surgery GA QK363 UT WOS:A1995QK36300002 PM 7874336 ER PT J AU STRICKMAN, D WIRTZ, R LAWYER, P GLICK, J STOCKWELL, S PERICH, M AF STRICKMAN, D WIRTZ, R LAWYER, P GLICK, J STOCKWELL, S PERICH, M TI METEOROLOGICAL EFFECTS ON THE BITING ACTIVITY OF LEPTOCONOPS AMERICANUS (DIPTERA, CERATOPOGONIDAE) SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article ID SOUTHERN-CALIFORNIA; DESERT AB Collections of biting Leptoconops americanus were made at half-hour intervals throughout the daylight hours on Stansbury Island, UT, during 9 days in May, 1993. The most favorable conditions for biting (greater than or equal to 90 bites on the ears in 15 min) included temperatures higher than 15 degrees C, minimum wind (<5 kph), minimum cloud cover, maximum sun, and no rain. Temperatures below 10 degrees C or the presence of rain prevented almost all biting. Higher winds and cloudiness decreased biting activity, but did not eliminate it if other conditions were favorable. Although not statistically significant, there was some suggestion from the data that higher temperatures (>25 degrees C) reduced biting. The flies did not appear to be more numerous at any particular part of the day; the biting rate simply followed meteorological conditions at the time. Ambient light varied between 1 and 10,000 foot candles during the study, with high biting rates (76 and 99 bites per 15 min) observed at levels as low as 80-100 foot candles. RP STRICKMAN, D (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307, USA. NR 15 TC 5 Z9 6 U1 0 U2 0 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD MAR PY 1995 VL 11 IS 1 BP 15 EP 20 PG 6 WC Entomology SC Entomology GA QV796 UT WOS:A1995QV79600004 PM 7616184 ER PT J AU MURTY, KG DJANG, P BUTLER, W LAFERRIERE, R AF MURTY, KG DJANG, P BUTLER, W LAFERRIERE, R TI THE ARMY TRAINING MIX MODEL SO JOURNAL OF THE OPERATIONAL RESEARCH SOCIETY LA English DT Article DE MILITARY TRAINING; COST EFFECTIVE TRAINING STRATEGIES; MIXED INTEGER PROGRAMMING; LINEAR PROGRAMMING AB We describe a model for making decisions concerning the proper mix of TADSS (training aids, devices, simulator and simulations) and conventional training resources, and the best modes of using them to maintain solider and unit proficiency. Given the proficiency standards, the model determines the resources needed the training methods for using them, and the frequency with which each method needs to be repeated, in order to maintain the standards at minimum cost (sum of equipment procurement costs and operational costs). The model is illustrated with an example problem dealing with the analysis of training systems in a battalion training strategy. Our model has much wider applicability: it can be used for evaluating and determining minimum cost training strategies for other combined arms elements, higher level units and other training scenarios under a variety of circumstances. C1 USA,TRAINING & DOCTRINE COMMAND,WASHINGTON,DC 20310. RP MURTY, KG (reprint author), UNIV MICHIGAN,DEPT IND & OPERAT ENGN,ANN ARBOR,MI 48109, USA. NR 1 TC 2 Z9 3 U1 0 U2 1 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HANTS, ENGLAND RG21 2XS SN 0160-5682 J9 J OPER RES SOC JI J. Oper. Res. Soc. PD MAR PY 1995 VL 46 IS 3 BP 294 EP 303 PG 10 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA QK460 UT WOS:A1995QK46000002 ER PT J AU HAMELINK, JK TANG, DB BARR, CF JACKSON, MR REID, TJ GOMEZ, ER ALVING, BM AF HAMELINK, JK TANG, DB BARR, CF JACKSON, MR REID, TJ GOMEZ, ER ALVING, BM TI INHIBITION OF PLATELET DEPOSITION BY COMBINED HIRULOG AND ASPIRIN IN A RAT CAROTID ENDARTERECTOMY MODEL SO JOURNAL OF VASCULAR SURGERY LA English DT Article ID THROMBIN INHIBITOR; RECOMBINANT HIRUDIN; DIRECT ANTITHROMBIN; HEPARIN; ANTICOAGULANT; INTERRUPTION; BABOONS; THROMBOLYSIS; ANGIOPLASTY; REOCCLUSION AB Purpose: Hirulog, a thrombin-specific inhibitor, has shown efficacy in reducing arterial thrombosis in patients treated with aspirin who require angioplasty or have unstable angina. In this study, the effect of hirulog on reducing deposition of indium(111)-labeled platelets was assessed in a surgical model of aspirin-treated rats undergoing carotid endarterectomy. Methods: Animals were randomly assigned to one of five groups: control (no aspirin or hirulog); aspirin alone (10 mg/kg); aspirin plus low-dose hirulog (0.2 mg/kg bolus followed by 0.5 mg/kg/hr); aspirin plus medium-dose hirulog (0.4 mg/kg bolus followed by 1.0 mg/kg/hr); or aspirin plus high-dose hirulog (0.6 mg/kg bolus followed by 1.5 mg/kg/hr). Hirulog was infused before surgery and continued until termination of the experiment 30 minutes after endarterectomy. Results: Platelet deposition in rats receiving aspirin atone was reduced by 19% +/- 23% SE (p = 0.26) compared with controls. Deposition in aspirin-treated groups receiving low-, medium-, and high-dose hirulog decreased in a dose-dependent manner by 37% +/- 20% (p = 0.048), 44% +/- 19% (p = 0.061), and 56% +/- 13% (p = 0.022), respectively. As the dose of hirulog was increased, the plasma hirulog levels and activated partial thromboplastin time ratios (final:initial) also increased in a dose-dependent manner. The mean plasma hirulog levels ranged from 0.74 +/- 0.08 mu g/ml in the low-dose hirulog group to 2.55 +/- 0.08 mu g/ml in the high-dose hirulog group, and the corresponding activated partial thromboplastin time ratios were 1.5 +/- 0.12 (p = 0.001) and 3.3 +/- 0.63 (p = 0.001). Bleeding was easily controlled by local hemostatic measures for all experimental groups. Conclusion: Hirulog causes significant decrease in In-111-labeled platelet deposition in aspirin-treated rats subjected to microsurgical endarterectomy at doses that allow surgical hemostasis to be easily established. C1 WALTER REED ARMY MED CTR,DEPT HEMATOL & VASC BIOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT BIOMETR & STAT,WASHINGTON,DC 20307. NR 32 TC 10 Z9 10 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD MAR PY 1995 VL 21 IS 3 BP 492 EP 498 DI 10.1016/S0741-5214(95)70292-X PG 7 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA QL648 UT WOS:A1995QL64800019 PM 7877232 ER PT J AU MICHAEL, NL MO, T MERZOUKI, A OSHAUGHNESSY, M OSTER, C BURKE, DS REDFIELD, RR BIRX, DL CASSOL, SA AF MICHAEL, NL MO, T MERZOUKI, A OSHAUGHNESSY, M OSTER, C BURKE, DS REDFIELD, RR BIRX, DL CASSOL, SA TI HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 CELLULAR RNA LOAD AND SPLICING PATTERNS PREDICT DISEASE PROGRESSION IN A LONGITUDINALLY STUDIED COHORT SO JOURNAL OF VIROLOGY LA English DT Article ID POLYMERASE CHAIN-REACTION; LONG TERMINAL REPEAT; VIRAL MESSENGER-RNA; REV GENE-PRODUCT; CD4+ T-CELLS; PERIPHERAL-BLOOD; TRANSCRIPTIONAL ELONGATION; HIV-INFECTION; HTLV-III; EXPRESSION AB We report the results of a longitudinal study of RNA splicing patterns in 31 early stage human immuno deficiency virus disease patients with an average follow-up time of 3 years. Eighteen patients showed no evidence for disease progression, whereas 13 patients either showed a greater than or equal to 50% reduction in baseline CD4 count or developed opportunistic infections. Levels of unspliced, tat, rev, and nef mRNAs in peripheral blood mononuclear cells were measured by a reverse transcriptase quantitative, competitive PCR assay. Viral RNA was detected in all patients at ah time points. Ah 13 rapid progressors had viral RNA loads that were greater than or equal to 1 log unit greater than those of the slow progressors. In addition, seven of the rapid progressors showed a reduction of more than threefold in the ratio of spliced to unspliced RNA over the 3 years of follow-up. Conversely, two Slow progressors with intermediate levels of viral RNA showed no splicing shift. These results confirm earlier observations that viral RNA is uniformly expressed in early-stage patients. We further show that cellular RNA viral load is predictive of disease progression. Importantly, the shift from a predominately spliced or regulatory viral mRNA pattern to a predominately unspliced pattern both is associated with disease progression and adds predictive utility to measurement of either RNA class alone. C1 WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. BRITISH COLUMBIA CTR EXCELLENCE HIV AIDS,VANCOUVER,BC,CANADA. OI /0000-0002-5704-8094 NR 55 TC 77 Z9 77 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD MAR PY 1995 VL 69 IS 3 BP 1868 EP 1877 PG 10 WC Virology SC Virology GA QG073 UT WOS:A1995QG07300060 PM 7853528 ER PT J AU BRUNO, FF AKKARA, JA SAMUELSON, LA KAPLAN, DL MANDAL, BK MARX, KA KUMAR, J TRIPATHY, SK AF BRUNO, FF AKKARA, JA SAMUELSON, LA KAPLAN, DL MANDAL, BK MARX, KA KUMAR, J TRIPATHY, SK TI ENZYMATIC MEDIATED SYNTHESIS OF CONJUGATED POLYMERS AT THE LANGMUIR TROUGH AIR-WATER-INTERFACE SO LANGMUIR LA English DT Article ID HORSERADISH-PEROXIDASE; BLODGETT-FILMS; POLYMERIZATION; OXIDATION; KINETICS; SURFACE; PHENOLS; CRESOL; ACIDS AB An approach for the enzyme-mediated in-situ synthesis of polymers in two dimensions on a Langmuir trough surface is reported. Horseradish peroxidase-mediated polymerization of monomer mixtures of unsubstituted and long alkyl chain substituted phenols and aromatic amines at the air-water interface was demonstrated. The use of the Langmuir trough to organize and orient the reactants results in improved control of monomer reactivity and orientation in the resulting polymer compared to the polymer synthesized in bulk solvent. In turn, this enhanced control results in improved processability because of reduced chain branching. Good thermal stability and significant electronic and optical properties of the ordered polymer were demonstrated. This interfacial polymerization procedure creates opportunities in the development of improved materials for applications in biology, medicine, and microelectronics. C1 UNIV MASSACHUSETTS,DEPT CHEM,CTR ADV MAT,LOWELL,MA 01854. USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. NR 22 TC 61 Z9 63 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0743-7463 J9 LANGMUIR JI Langmuir PD MAR PY 1995 VL 11 IS 3 BP 889 EP 892 DI 10.1021/la00003a035 PG 4 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA QP595 UT WOS:A1995QP59500035 ER PT J AU BYRNE, CA DESPER, CR SCHNEIDER, NS LI, YJ CHU, B AF BYRNE, CA DESPER, CR SCHNEIDER, NS LI, YJ CHU, B TI POLYETHYLENE-BASED POLYURETHANE COPOLYMERS AND BLOCK-COPOLYMERS SO MACROMOLECULAR SYMPOSIA LA English DT Article; Proceedings Paper CT Recent Advances in the Synthesis and Characterization of Block and Graft Copolymers CY AUG 22-27, 1993 CL CHICAGO, IL SP AMER CHEM SOC, DIV POLYM CHEM ID SEGMENTED POLYURETHANES; POLYOLEFIN; ELASTOMERS AB Low molecular weight hydroxy terminated polyethylene (HTPE) containing on average an ethyl group every 16-18 carbon atoms, and a hydroxy functionality of 2.6, has been used to prepare polyurethane copolymers and block copolymers which have good solvent resistance. The polymers show somewhat complicated thermal behavior, including T-g's at around -40 degrees C due to the HTPE and diffuse endotherms between 40 and 60 degrees C. The simple copolymers, containing only the polyol and a diisocyanate, show infrared evidence for two phases in the case where CHDI (trans-1,4-diisocyanatocyclohexane) was used, and poorer phase separation where other diisocyanates were used. Dynamic mechanical spectra show very broad tan delta transitions for the copolymers in the range of -9 to -23 degrees C. All the polymers exhibit another transition in the G'' curve above room temperature. SAXS reveals a microphase separated structure at 30 degrees C for the simple copolymers which increases in spacing, then disappears in the 60-70 degrees C range. With cooling, the microphase separated structure reappears readily for the CHDI-based copolymer, while its reappearance shows a hysteresis resulting from rate effects for the other copolymers. C1 GEOCENTERS INC,NEWTON,MA 02159. SUNY STONY BROOK,DEPT CHEM,STONY BROOK,NY 11794. RP BYRNE, CA (reprint author), USA,RES LAB,POLYMER RES BRANCH,WATERTOWN,MA 02172, USA. NR 22 TC 4 Z9 4 U1 0 U2 7 PU HUTHIG & WEPF VERLAG PI BASEL PA AUF DEM WOLF 4 FX#001-41-61-317-94-11, CH-4052 BASEL, SWITZERLAND SN 1022-1360 J9 MACROMOL SYMP JI Macromol. Symp. PD MAR PY 1995 VL 91 BP 1 EP 26 DI 10.1002/masy.19950910103 PG 26 WC Polymer Science SC Polymer Science GA QU128 UT WOS:A1995QU12800002 ER PT J AU MATHER, B SADEGZADEH, M PAGE, CL VASSIE, PRW AF MATHER, B SADEGZADEH, M PAGE, CL VASSIE, PRW TI EFFECTS OF UREA ON DURABILITY OF REINFORCED-CONCRETE - DISCUSSION SO MAGAZINE OF CONCRETE RESEARCH LA English DT Article RP MATHER, B (reprint author), USA,ENGINEER WATERWAYS EXPT STN,STUCT LAB,VICKSBURG,MS 39180, USA. NR 9 TC 1 Z9 1 U1 0 U2 3 PU THOMAS TELFORD SERVICES LTD PI LONDON PA THOMAS TELFORD HOUSE, 1 HERON QUAY, LONDON, ENGLAND E14 4JD SN 0024-9831 J9 MAG CONCRETE RES JI Mag. Concr. Res. PD MAR PY 1995 VL 47 IS 170 BP 93 EP 94 PG 2 WC Construction & Building Technology; Materials Science, Multidisciplinary SC Construction & Building Technology; Materials Science GA QY679 UT WOS:A1995QY67900012 ER PT J AU Burrows, EP AF Burrows, EP TI Dimethyl ether chemical ionization mass spectrometry SO MASS SPECTROMETRY REVIEWS LA English DT Review ID ION-MOLECULE REACTIONS; COLLISIONALLY ACTIVATED DISSOCIATION; FUNCTIONAL-GROUP INTERACTIONS; DOUBLE-BONDS; LOCATION; GAS AB The uses of dimethyl ether (DME) as an unusual positive ion reagent for chemical ionization mass-spectrometry (CIMS) are reviewed. The fragment-molecule adducts formed by ion-molecule reactions of organic substrates with the ionized gas are highly characteristic for the substrates and frequently can be used to differentiate among isomers. The fragmentation mechanisms of the adducts have been studied by collision-induced dissociation and with deuterium labeling, and, in some cases, are well-understood. DME CIMS has been applied to a wide variety of classes of organic compounds, including substituted aromatics, amino alcohols, lactones, lactams, polyethylene glycols, benzodiazepines, azepines, trichothecenes, and certain alkaloids, nucleoside antibiotics, and polynuclear aromatic hydrocarbons. (C) 1995 John Wiley & Sons, Inc. RP Burrows, EP (reprint author), USA,CHPPM RES DETACHMENT,FT DETRICK,FT DETRICK,MD 21702, USA. NR 27 TC 20 Z9 20 U1 0 U2 5 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0277-7037 J9 MASS SPECTROM REV JI Mass Spectrom. Rev. PD MAR PY 1995 VL 14 IS 2 BP 107 EP 115 DI 10.1002/mas.1280140204 PG 9 WC Spectroscopy SC Spectroscopy GA UA281 UT WOS:A1995UA28100003 ER PT J AU HARTUNG, GH BLANCQ, RJ LALLY, DA KROCK, LP AF HARTUNG, GH BLANCQ, RJ LALLY, DA KROCK, LP TI ESTIMATION OF AEROBIC CAPACITY FROM SUBMAXIMAL ERGOMETRY IN WOMEN SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE HEART RATE; OXYGEN UPTAKE; EXERCISE TEST; SUBMAXIMAL ERGOMETRY ID MAXIMAL OXYGEN-UPTAKE; VO2MAX AB Simple, valid, and reliable methods of estimating maximal oxygen uptake (VO2max) are needed for epidemiologic studies of physical activity, to evaluate fitness for job performance, and to assist in prescription of exercise. Such estimations in women have not received due research attention. Heart rate responses to submaximal cycle ergometry and VO2max during maximal treadmill and cycle ergometer resting were measured in 37 healthy women aged 19-47 yr ((X) over bar = 31.7 +/- 7.9). The submaximal test was very reliable on retest (r 0.92), but overestimated measured treadmill VO2max ((X) over bar = 2.42 vs 2.23 l . min(-1); r = 0.76, SEE = 0.229). The submaximal test also greatly overestimated maximal cycle ergometer VO2max ((X) over bar = 2.42 vs 2.06 l . min(-1); r = 0.70, SEE = 0.340). Similar 8.5% (treadmill) and 18.5% (cycle ergometer) overestimations by the submaximal test were found for VO2max relative to body weight. A simple submaximal exercise test is highly reliable as an estimate of VO2max when used for women. It also provides a reasonably good estimate of treadmill measured VO2max. C1 UNIV HAWAII,JOHN A BURNS SCH MED,DEPT PHYSIOL,HONOLULU,HI 96822. ARMSTRONG LAB,DIV CREW TECHNOL,FLIGHT MOT EFFECTS BRANCH,BROOKS AFB,TX 78235. RP HARTUNG, GH (reprint author), TRIPLER ARMY MED CTR,DEPT MED,DMC,HSHK,SERV CARDIOL,HONOLULU,HI 96859, USA. NR 29 TC 25 Z9 26 U1 3 U2 18 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAR PY 1995 VL 27 IS 3 BP 452 EP 457 PG 6 WC Sport Sciences SC Sport Sciences GA QM259 UT WOS:A1995QM25900024 PM 7752875 ER PT J AU LALL, P PECHT, M HAKIM, EB AF LALL, P PECHT, M HAKIM, EB TI CHARACTERIZATION OF FUNCTIONAL-RELATIONSHIP BETWEEN TEMPERATURE AND MICROELECTRONIC RELIABILITY SO MICROELECTRONICS AND RELIABILITY LA English DT Article ID SILICON-OXIDES; BREAKDOWN; SIO2 AB The functional relationship between temperature and microelectronic reliability is presently characterized by an Arrhenius relationship. The Arrhenius relationship encourages lowering temperature to achieve reliability goals. In this paper, the role of temperature in achieving cost-effective reliable electronic equipment has been investigated. The effect of temperature on reliability has been evaluated based on failure mechanisms and electrical parameter variations. The device investigated in this paper is assumed to consist of a bipolar or MOSFET (silicon) semiconductor device with device packaging consisting of first-level interconnects that may be wirebonds, flip-chip, or tape automated bonds, die attachment, substrate attachment, case, lid, lid seal and lead seal. Failure mechanisms actuated under various temperature stresses, including steady-state temperature, temperature cycling, temperature gradients, and time-dependent temperature change, have been identified for each of the package elements. A methodology for derivation of the functional relationship between temperature and microelectronic reliability has been discussed. C1 USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,COMPONENT RELIABIL BRANCH,AMSRL,EP,RA,FT MONMOUTH,NJ 07703. RP LALL, P (reprint author), UNIV MARYLAND,ELECTR PACKAGING RES CTR,CALCE,COLLEGE PK,MD 20742, USA. OI Pecht, Michael/0000-0003-1126-8662 NR 82 TC 18 Z9 18 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0026-2714 J9 MICROELECTRON RELIAB JI Microelectron. Reliab. PD MAR PY 1995 VL 35 IS 3 BP 377 EP 402 DI 10.1016/0026-2714(95)93067-K PG 26 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA QJ905 UT WOS:A1995QJ90500004 ER PT J AU STRETCH, RH BLIESE, PD MARLOWE, DH WRIGHT, KM KNUDSON, KH HOOVER, CH AF STRETCH, RH BLIESE, PD MARLOWE, DH WRIGHT, KM KNUDSON, KH HOOVER, CH TI PHYSICAL HEALTH SYMPTOMATOLOGY OF GULF-WAR ERA SERVICE PERSONNEL FROM THE STATES OF PENNSYLVANIA AND HAWAII SO MILITARY MEDICINE LA English DT Article AB We present data on physical health and possible ''Gulf War syndrome'' from a Congressionally mandated study of over 4,000 active duty and reserve service members from the states of Hawaii and Pennsylvania who served during Operation Desert Storm. We found that deployed veterans report significantly more physical health symptoms than non-deployed veterans that cannot be explained by reasons other than deployment alone. We also identified a subgroup of 178 deployed veterans at risk for possible Gulf War syndrome. We recommend that services collect baseline information from units likely to deploy in the future and update that information regularly. RP STRETCH, RH (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307, USA. NR 0 TC 51 Z9 51 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 1995 VL 160 IS 3 BP 131 EP 136 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA QY950 UT WOS:A1995QY95000010 PM 7783936 ER PT J AU HANSEN, HK AF HANSEN, HK TI CAMP FLOYD AND THE MORMONS - THE UTAH WAR - MOORMAN,DR, SESSION,GA SO MONTANA-THE MAGAZINE OF WESTERN HISTORY LA English DT Book Review RP HANSEN, HK (reprint author), USA,COLL WAR,CARLISLE,PA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MONTANA HISTORICAL SOC PI HELENA PA 225 N ROBERTS ST, HELENA, MT 59601 SN 0026-9891 J9 MONTANA JI Mont.-Mag. West. Hist. PD SPR PY 1995 VL 45 IS 2 BP 74 EP 75 PG 2 WC History SC History GA RD162 UT WOS:A1995RD16200014 ER PT J AU JOHNSON, RE ISENSEE, EK ALLISON, WT AF JOHNSON, RE ISENSEE, EK ALLISON, WT TI A STOCHASTIC VERSION OF THE CONCEPTS EVALUATION MODEL (CEM) SO NAVAL RESEARCH LOGISTICS LA English DT Article AB The concepts evaluation model (CEM) is a computer simulation model of ground and air warfare operations that is used by the U.S. Army Concepts Analysis Agency (CAA) to conduct analysis of the capabilities and requirements of forces engaged in warfare at theater level. The CEM has been applied to campaign analyses for numerous scenarios since the early 1970s, including Central Europe, Korea, Iran, and Iraq theaters of operation. The standard CEM is fully automated and deterministic, yielding a single outcome for any situation simulated, providing no confidence intervals, range, nor distribution of possible outcomes. Modern, faster computers have now reduced CEM execution time to a level that makes multiple replications of the CEM feasible. In this project a stochastic version of the CEM has been developed that makes use of individual replications of stochastic attrition input data, rather than averaged sample data, and that simulates commanders' decisions, the disposition of casualties and of combat-damaged vehicles, and certain other functions based on statistical distributions rather than on expected values. This article reports the methodology and results of an analysis of this stochastic version of CEM, indicating which stochastic features most influenced the variability among replications of one simulated campaign and outlining costs and benefits of using a stochastic version of the CEM (C) 1995 John Wiley and Sons, Inc.* RP JOHNSON, RE (reprint author), USA,CONCEPTS ANAL AGCY,BETHESDA,MD, USA. RI Allison, W. Ted/K-5228-2012 NR 3 TC 2 Z9 2 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0894-069X J9 NAV RES LOG JI Nav. Res. Logist. PD MAR PY 1995 VL 42 IS 2 BP 233 EP 246 DI 10.1002/1520-6750(199503)42:2<233::AID-NAV3220420207>3.0.CO;2-G PG 14 WC Operations Research & Management Science SC Operations Research & Management Science GA QH845 UT WOS:A1995QH84500005 ER PT J AU GUNDERSON, CH AF GUNDERSON, CH TI THE IMPACT OF NEW PHARMACEUTICAL AGENTS OF THE COST OF NEUROLOGIC CARE SO NEUROLOGY LA English DT Article ID UNITED-STATES; ALZHEIMERS-DISEASE; DOUBLE-BLIND; SUMATRIPTAN; PREVALENCE; FELBAMATE; MIGRAINE; HEADACHE; DEPRENYL; DEMENTIA AB Since the emergence of the specialty, neurologists have worked with a rather restricted list of relatively inexpensive pharmacologic agents. This is rapidly changing with the development of new agents for the treatment of migraine, multiple sclerosis, Parkinson's disease, Alzheimer's disease, and epilepsy, accelerated in part by designation of the 1990s as the ''Decade of the Brain.'' Exciting as these developments are, they are very costly when applied to the large number of patients who may benefit, perhaps exceeding $6.4 billion. Since this cost exceeds the $1.5 billion income of all practicing neurologists, it enhances the value of the neurologic consultation, which can provide more accurate diagnosis and more expertly directed therapy. Our relationships with the drug manufacturers are changing as our prescribing habits become a more likely determinant of profits. C1 WALTER REED ARMY MED CTR,NEUROL SERV,WASHINGTON,DC 20307. RP GUNDERSON, CH (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT NEUROL,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 21 TC 20 Z9 20 U1 0 U2 0 PU LITTLE BROWN CO PI BOSTON PA 34 BEACON STREET, BOSTON, MA 02108-1493 SN 0028-3878 J9 NEUROLOGY JI Neurology PD MAR PY 1995 VL 45 IS 3 BP 569 EP 572 PN 1 PG 4 WC Clinical Neurology SC Neurosciences & Neurology GA QM902 UT WOS:A1995QM90200036 PM 7898720 ER PT J AU MCDONOUGH, JH DOCHTERMAN, LW SMITH, CD SHIH, TM AF MCDONOUGH, JH DOCHTERMAN, LW SMITH, CD SHIH, TM TI PROTECTION AGAINST NERVE AGENT-INDUCED NEUROPATHOLOGY, BUT NOT CARDIAC PATHOLOGY, IS ASSOCIATED WITH THE ANTICONVULSANT ACTION OF DRUG-TREATMENT SO NEUROTOXICOLOGY LA English DT Article DE NERVE AGENTS; SOMAN; SEIZURE; NEUROPATHOLOGY; CARDIOMYOPATHY; ANTICONVULSANTS ID SOMAN-INDUCED SEIZURES; BLOOD-BRAIN-BARRIER; STATUS-EPILEPTICUS; INTOXICATED RATS; POISONED RATS; HIPPOCAMPUS; GLUTAMATE; COMPOUND; DAMAGE; ACETYLCHOLINE AB Brain and cardiac tissue was examined for pathological changes from rats that survived 24 hrs following exposure to a convulsant dose of the nerve agent soman. The animals had been treated following varying durations of seizure activity (2.5 - 40 min) with a number of different compounds that did or did not terminate the seizure. Moderate to severe neuropathology was evident in virtually all animals (98%) in which drug treatment did not terminate seizures. All animals that experienced up to 10 min of seizure activity before drug treatment successfully terminated the seizure were free of neuropathology. There was an increasing frequency in the incidence of neuropathology in animals that experienced 20 (10%) or 40 min (79%) of seizure activity before drug treatment terminated the seizure, but the degree of neuropathology in these groups was significantly less than that observed in animals where seizure activity was not terminated. Cardiac lesions occurred at a much higher frequency (88%) than neuropathological changes (57%) and were not consistently associated with the anticonvulsant effectiveness. Early treatment (less than or equal to 10 min) with anticholinergic drugs, however, was associated with protection from cardiac damage. The results strongly support the hypothesis that nerve agent-induced brain damage is linked to epileptiform activity. The minimal amount of seizure activity necessary for irreversible neural damage to become evident under these conditions is similar to 20 min, and the process accelerates greatly after this minimal time has elapsed. Successful termination of seizure activity, regardless of the type of drug used, protected either totally or relatively against brain damage depending upon how long the seizure had progressed. The mechanisms responsible for cardiac lesion formation occur more rapidly and may have a cholinergic component. (C) 1995 Intox Press, Inc. C1 USA,MED RES INST CHEM DEF,DEPT COMPARAT PATHOL,MSMR,UV,PA,ABERDEEN PROVING GROUND,MD 21010. RP MCDONOUGH, JH (reprint author), USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,MSMR,UV,PA,ABERDEEN PROVING GROUND,MD 21010, USA. NR 41 TC 46 Z9 47 U1 0 U2 1 PU INTOX PRESS INC PI LITTLE ROCK PA PO BOX 24865, LITTLE ROCK, AR 72221 SN 0161-813X J9 NEUROTOXICOLOGY JI Neurotoxicology PD SPR PY 1995 VL 16 IS 1 BP 123 EP 132 PG 10 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA QV617 UT WOS:A1995QV61700013 PM 7603632 ER PT J AU YANCEY, MK DUFF, P AF YANCEY, MK DUFF, P TI ACUTE HYPOTENSION RELATED TO SEPSIS IN THE OBSTETRIC PATIENT SO OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA LA English DT Article ID ANTIENDOTOXIN MONOCLONAL-ANTIBODIES; GRAM-NEGATIVE BACTEREMIA; SEPTIC SHOCK; OXYGEN DELIVERY; FLUID RESUSCITATION; SURGICAL PATIENTS; CONSUMPTION; PATHOGENESIS; PREGNANCY; TRIAL AB Localized bacterial infections, primarily involving the genitourinary tract, are relatively common during pregnancy. Ln rare instances, these localized infections can lead to bacteremia and the clinical manifestations of the sepsis syndrome and septic shock. Sepsis is the general term that describes the constellation of clinical signs and symptoms associated with the host response to circulating bacterial exotoxins and endotoxins. Definitions for sepsis, sepsis syndrome, and septic shock are listed in Table 1. These conditions occur as circulating endotoxins or exotoxins trigger the systemic activation of cytokines, complement, coagulation factors, and immune cellular elements. The basic pathophysiology of the sepsis syndrome and septic shock can generally be thought of as the result of host defense mechanisms gone awry. In approximately 5% of bacteremic obstetric patients, the sepsis syndrome will be accompanied by significant hypotension and can be classified as septic shock.(4,14) Sepsis syndrome and septic shock are progressive states of impaired perfusion of multiple organs that results in dysfunction of these organs.(11) Dysfunction occurs in spite of cardiovascular homeostatic mechanisms that attempt to maintain tissue oxygen delivery in the face of profound pathophysiologic alterations. The early clinical signs and symptoms of the sepsis syndrome can easily be mistaken for an acute response to moderate hypovolemia or increased circulating catecholamines due to pain or anxiety. Later findings will reflect marked disruption of tissue perfusion and progressive end-organ dysfunction. If sepsis is unrecognized or inadequately treated, mortality may be alarmingly high. However, early recognition and treatment with antimicrobials and cardiovascular supportive measures can result in a marked reduction in the morbidity and mortality associated with this condition. C1 UNIV FLORIDA,COLL MED,DEPT GYNECOL & OBSTET,DIV MATERNAL FETAL MED,GAINESVILLE,FL. RP YANCEY, MK (reprint author), TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,MATERNAL FETAL MED SERV,HONOLULU,HI 96859, USA. NR 29 TC 1 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0889-8545 J9 OBSTET GYN CLIN N AM JI Obstet. Gynecol. Clin. N. Am. PD MAR PY 1995 VL 22 IS 1 BP 91 EP 109 PG 19 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA QM292 UT WOS:A1995QM29200008 PM 7784043 ER PT J AU WORTMAN, DE MORRISON, CA AF WORTMAN, DE MORRISON, CA TI ANALYSIS OF THE ENERGY-LEVELS OF MN2+ IN HALO APATITE STRUCTURES SO OPTICAL MATERIALS LA English DT Article ID CALCIUM FLUOROPHOSPHATE; IONS; PHOSPHORS; LOCATION; CENTERS AB Reported optical spectra of Mn2+-doped halo apatites are analyzed in octahedral, cubic, and C-3 symmetries. Specifically the apatites doped with Mn2+ are Ca10F2(PO4)(6), Cd10Cl2(PO4)(6), Ca10F1.8Cl0.2(PO4)(6), and Sr10F1.8Cl0.2(PO4)6. The cubic approximation was assisted by the use of Tanabe-Sugano-like plots, and the experimental data were averaged for a best analysis where the Slater parameters F-(2) and F-(4) and the crystal-field parameter B-40 were varied. A point charge calculation of the crystal-field parameters for the C-3 sites in each of the apatites and the resulting crystal-field parameters, B-20, B-40, and B-43, were used as starting values in fitting the reported energy levels in C-3 symmetry. The parameters that best fit both the cubic approximation and the C-3 symmetry are given for each of the apatite host crystals. RP WORTMAN, DE (reprint author), USA,RES LAB,ADELPHI,MD 20783, USA. NR 45 TC 6 Z9 6 U1 1 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0925-3467 J9 OPT MATER JI Opt. Mater. PD MAR PY 1995 VL 4 IS 4 BP 487 EP 505 DI 10.1016/0925-3467(94)00124-3 PG 19 WC Materials Science, Multidisciplinary; Optics SC Materials Science; Optics GA QW267 UT WOS:A1995QW26700007 ER PT J AU VIDEEN, G AF VIDEEN, G TI LIGHT-SCATTERING FROM A PARTICLE ON OR NEAR A PERFECTLY CONDUCTING SURFACE SO OPTICS COMMUNICATIONS LA English DT Note ID CLASSICAL ELECTROMAGNETIC SCATTERING; CONSUMMATE SOLUTION; SPHERES; PLANE; SUBSTRATE; ENSEMBLE AB A formal solution to the scattered field of a particle of arbitrary shape and optical constants located on or near a perfectly conducting surface is derived. The solution is in terms of a vector harmonic expansion. The only knowledge required of the particle is its scattering coefficients when the plane surface is not present. It is sufficiently general that the particle can be inhomogeneous or represent a set of subparticles. C1 ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM. NR 24 TC 21 Z9 21 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD MAR 1 PY 1995 VL 115 IS 1-2 BP 1 EP 7 DI 10.1016/0030-4018(94)00668-K PG 7 WC Optics SC Optics GA QK598 UT WOS:A1995QK59800001 ER PT J AU KLEMME, WR PETERSEN, SA AF KLEMME, WR PETERSEN, SA TI AVULSION OF THE TRICEPS BRACHII WITH SELECTIVE RADIAL NEUROPATHY SO ORTHOPEDICS LA English DT Note RP KLEMME, WR (reprint author), TRIPLER ARMY MED CTR,ORTHOPED SERV,HONOLULU,HI 96859, USA. NR 0 TC 8 Z9 8 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD MAR PY 1995 VL 18 IS 3 BP 285 EP 287 PG 3 WC Orthopedics SC Orthopedics GA QM700 UT WOS:A1995QM70000008 PM 7761319 ER PT J AU JOHNSON, RE STAMBAUGH, CKI RICHMOND, MH BALBUENA, L AF JOHNSON, RE STAMBAUGH, CKI RICHMOND, MH BALBUENA, L TI TORTUOUS INTERNAL CAROTID-ARTERY PRESENTING AS AN OROPHARYNGEAL MASS SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Note CT 1993 Annual Meeting of the American-Academy-of-Otolaryngology - Head-and-Neck-Surgery CY OCT 02-06, 1993 CL MINNEAPOLIS, MN SP AMER ACAD OTOLARYNGOL, HEAD & NECK SURG C1 WALTER REED ARMY MED CTR,OTOLARYNGOL HEAD & NECK SURG SERV,FT HOOD,TX. DARNELL ARMY COMMUNITY HOSP,OTOLARYNGOL HEAD & NECK SURG SERV,WASHINGTON,DC. RP JOHNSON, RE (reprint author), BROOKE ARMY MED CTR,HSHE SDT,OTOLARYNGOL HEAD & NECK SURG SERV,FT SAM HOUSTON,TX 78234, USA. NR 10 TC 4 Z9 6 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD MAR PY 1995 VL 112 IS 3 BP 479 EP 482 DI 10.1016/S0194-5998(95)70290-3 PG 4 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA QK715 UT WOS:A1995QK71500023 PM 7870456 ER PT J AU DHAWAN, S HEREDIA, A WAHL, LM EPSTEIN, JS MELTZER, MS HEWLETT, IK AF DHAWAN, S HEREDIA, A WAHL, LM EPSTEIN, JS MELTZER, MS HEWLETT, IK TI INTERFERON-GAMMA-INDUCED DOWN-REGULATION OF CD4 INHIBITS THE ENTRY OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 IN PRIMARY MONOCYTES SO PATHOBIOLOGY LA English DT Article DE HUMAN IMMUNODEFICIENCY VIRUS TYPE-1; PATHOGENESIS; MONOCYTES; INTERFERON-GAMMA; TUMOR NECROSIS FACTOR-ALPHA ID IFN-GAMMA; MONONUCLEAR PHAGOCYTES; INFECTED-CELLS; MACROPHAGES; AIDS; REPLICATION; ACTIVATION; MECHANISM; NITRITE; ALPHA AB We have previously shown that the treatment of monocytes with interferon-gamma (IFN-gamma) prior to exposure with human immunodeficiency virus type-1 (HIV) results in complete inhibition of HIV infection of monocytes. In the present report, we have extended this study to obtain information on the mechanism(s) underlying IFN-gamma-induced inhibition of HIV infection of monocytes. To examine the effect of IFN-gamma on HIV entry, the first event in the infectious cycle of the virus, we amplified HIV-gag sequences in the genomic DNA and RNA of IFN-gamma treated monocytes, and found no evidence for the presence of either proviral DNA or HIV RNA sequences. These results were consistent with the absence of intracellular HIV particles either in the latent or actively replicating state as determined by flow-cytometric analysis of these cells. Furthermore, no HIV-induced cytopathic effects, such as multinucleated giant cell formation or cell death, were observed in IFN-gamma-treated monocytes after their exposure to HIV. Stimulation of IFN-gamma-treated monocytes 6 days postinfection with tumor necrosis factor-alpha(TNF-alpha), which is known to augment HIV replication in the infected cells, did not result in the induction of the HIV indicating the absence of latent HIV infection in IFN-gamma-treated monocytes. Treatment of monocytes with IFN-gamma, TNF-alpha, or with a combination of the two agents which is known to induce antimicrobial free radical nitric oxide (NO2- in the murine system did not induce NO(2)(-)production human monocytes suggesting the antiviral activity of IFN-gamma to be independent of NO(2)(-)mediated killing of HIV or HIV-infected monocytes. Interestingly, CD4 expression on the surface of monocytes was substantially downregulated by IFN-gamma treatment, and was directly related to intracellular HIV-p24 levels. These results indicate that IFN-gamma-mediated inhibition of HIV infection of monocytes was not due to virus latency or killing of these cells, but was primarily due to downregulation of CD4 expression resulting in the inhibition of HIV entry into monocytes. C1 NIDR,IMMUNOL LAB,BETHESDA,MD 20892. WALTER REED ARMY INST RES,DEPT CELLULAR IMMUNOL,WASHINGTON,DC. RP DHAWAN, S (reprint author), US FDA,CTR BIOL EVALUAT & RES,DIV TRANSFUS TRANSMITTED DIS,MOLEC VIROL LAB,ROCKVILLE,MD 20852, USA. NR 23 TC 28 Z9 30 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1015-2008 J9 PATHOBIOLOGY JI Pathobiology PD MAR-APR PY 1995 VL 63 IS 2 BP 93 EP 99 DI 10.1159/000163939 PG 7 WC Cell Biology; Pathology SC Cell Biology; Pathology GA RY038 UT WOS:A1995RY03800006 PM 8554705 ER PT J AU SAMLASKA, CP DELORIMIER, AJ HELDMAN, LS AF SAMLASKA, CP DELORIMIER, AJ HELDMAN, LS TI EOSINOPHILIC PANNICULITIS SO PEDIATRIC DERMATOLOGY LA English DT Note AB Eosinophilic panniculitis is a poorly defined entity with variable clinical features. We report a case of rapidly enlarging, asymptomatic subcutaneous scalp nodules in a 6-year-old black boy with atopic dermatitis. The nodules resolved spontaneously over two to three days. Biopsy specimens were remarkable for eosinophilic panniculitis without evidence of epidermal change or vasculitis. We believe that this is the youngest reported patient with this disorder. RP SAMLASKA, CP (reprint author), TRIPLER ARMY MED CTR,DERMATOL SERV,HONOLULU,HI 96859, USA. NR 0 TC 3 Z9 5 U1 0 U2 0 PU BLACKWELL SCIENCE PUBL INC CAMBRIDGE PI CAMBRIDGE PA 238 MAIN ST, CAMBRIDGE, MA 02142 SN 0736-8046 J9 PEDIATR DERMATOL JI Pediatr. Dermatol. PD MAR PY 1995 VL 12 IS 1 BP 35 EP 38 DI 10.1111/j.1525-1470.1995.tb00121.x PG 4 WC Dermatology; Pediatrics SC Dermatology; Pediatrics GA QM417 UT WOS:A1995QM41700008 PM 7792217 ER PT J AU EASA, D FINN, KC BALARAMAN, V SOOD, S WILKERSON, S TAKENAKA, W MUNDIE, TG AF EASA, D FINN, KC BALARAMAN, V SOOD, S WILKERSON, S TAKENAKA, W MUNDIE, TG TI PRESERVATION OF PULMONARY-FUNCTION IN THE VENTILATED NEONATAL PIGLET WITH NORMAL LUNGS SO PEDIATRIC PULMONOLOGY LA English DT Article ID FREQUENCY OSCILLATORY VENTILATION; RESPIRATORY MECHANICS; PREMATURE-INFANTS; INJURY; ATELECTASIS; PRESSURE; RABBITS; ANESTHESIA; VOLUME AB Little attention has been focused on the progressive pulmonary deterioration which occurs in mechanically ventilated infants with normal or mildly abnormal lungs. We hypothesized that lung function would deteriorate over a 24-hr period in anesthetized neonatal piglets with normal lungs mechanically ventilated at 2 cm H2O PEEP (2PEEP group). We further hypothesized that an intermittent lung inflation procedure consisting of 15 out of 60 min of increasing lung distention (4, 8, 12 cm H2O PEEP), with the remaining 45 min at 2 cm H2O PEEP (Inflation group) would prevent this deterioration in lung function, similar to piglets mechanically ventilated continuously at 6 cm H2O PEEP (6PEEP). Results indicate that 2PEEP piglets experienced progressive deterioration in lung function, including dynamic lung compliance (-42%) and lung resistance (+55%). In contrast, Inflation piglets and 6PEEP piglets had no deterioration in lung function. Hemodynamics were similar between groups, although they were the most stable in the 6PEEP group. Histopathological changes were not significantly different. We conclude that (1) prolonged mechanical ventilation at 2 cm H2O PEEP in neonatal piglets resulted in progressive deterioration in pulmonary function, (2) intermittent lung inflation or continuous 6 cm H2O PEEP prevented deterioration, and (3) functional changes occurred without changes in histopathology. Lung inflation strategies other than PEEP can be used to prevent deterioration in lung function which accompanies prolonged mechanical ventilation in anesthetized nonspontaneously breathing piglets with normal lungs. (C) 1995 Wiley-Liss, Inc. C1 KAPIOLANI MED CTR WOMEN & CHILDREN,JOHN A BURNS SCH MED,DEPT RESP CARE,HONOLULU,HI 96826. TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT PATHOL,HONOLULU,HI 96859. RP EASA, D (reprint author), KAPIOLANI MED CTR WOMEN & CHILDREN,JOHN A BURNS SCH MED,DEPT PEDIAT,1319 PUNAHOU ST,HONOLULU,HI 96826, USA. NR 33 TC 2 Z9 2 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 8755-6863 J9 PEDIATR PULM JI Pediatr. Pulmonol. PD MAR PY 1995 VL 19 IS 3 BP 174 EP 181 DI 10.1002/ppul.1950190306 PG 8 WC Pediatrics; Respiratory System SC Pediatrics; Respiratory System GA QQ289 UT WOS:A1995QQ28900005 PM 7792120 ER PT J AU WHITEWELKLEY, JE BUNNELL, BN MOUGEY, EH MEYERHOFF, JL DISHMAN, RK AF WHITEWELKLEY, JE BUNNELL, BN MOUGEY, EH MEYERHOFF, JL DISHMAN, RK TI TREADMILL EXERCISE TRAINING AND ESTRADIOL DIFFERENTIALLY MODULATE HYPOTHALAMIC-PITUITARY-ADRENAL CORTICAL RESPONSES TO ACUTE RUNNING AND IMMOBILIZATION SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE STRESS; RAT MODEL; ACTH; CORTICOSTERONE; PROLACTIN; OVARIECTOMIZED ID PROLACTIN RESPONSE; STRESS RESPONSE; ESTROUS-CYCLE; FEMALE RATS; CORTICOSTERONE; HORMONE; FITNESS; ACTH; VASOPRESSIN; WOMEN AB It is generally believed that physical fitness promotes health by attenuating responsiveness to other stressors. The experimental evidence for this belief is limited and does not extend to interactions between the hypothalamic-pituitary-adrenal cortical (HPA) and hypothalamic-pituitary-gonadal (HPG) axes. We tested the hypothesis that treadmill exercise training would lead to an estrogen-dependent hyporesponsiveness of the HPA axis that would generalize to immobilization stress. Ovariectomized female Sprague-Dawley rats (N = 74) that had been treadmill trained (TT) or sedentary for 6 weeks received intramuscular injections of estradiol benzoate (Eb) or sesame oil on each of 3 days prior to 15 min of acute treadmill running or immobilization. Plasma (adrenocorticotrophin) (ACTH), (corticosterone) (B) and (prolactin) (PRL) were determined from trunk blood by radioimmunoassay and compared in a 2 group (TT vs. sedentary)-by-2 treatment (Eb vs. oil)-by-2 acute stressor (running vs. immobilization) design. Home-cage (HC) animals (N = 24) provided baseline hormone levels. ACTH and B levels were elevated after stressors in animals treated with either Eb or oil compared to HC, but increases in PRL after stressors were dependent on Eb. Treadmill exercise training led to an attenuation of ACTH and prolactin to running, but the attenuation did nor generalize to immobilization. In contrast, treadmill exercise training led to a hyperresponsiveness of ACTH. Treadmill training did not modulate prolactin responses to immobilization. The modulating effects of the estradiol treatment are consistent with an interaction of the HPA and HPG axes in response to stress. Whether such an interaction, and the increased cross-stressor responsiveness of ACTH we observed after exercise training, has positive or negative consequences for homeostasis and health requires study. C1 UNIV GEORGIA,DEPT EXERCISE SCI,ATHENS,GA 30602. UNIV GEORGIA,DEPT PSYCHOL,ATHENS,GA 30602. WALTER REED ARMY INST RES,DEPT MED NEUROSCI,WASHINGTON,DC. NR 50 TC 36 Z9 36 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD MAR PY 1995 VL 57 IS 3 BP 533 EP 540 DI 10.1016/0031-9384(94)00348-9 PG 8 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA QH074 UT WOS:A1995QH07400018 PM 7786348 ER PT J AU BERLIN, RH AF BERLIN, RH TI UNITED-STATES MARINES IN THE PERSIAN-GULF, 1990-1991 - WITH THE 1ST-MARINE-DIVISION IN DESERT-SHIELD AND DESERT-STORM - CURETON,CH SO PUBLIC HISTORIAN LA English DT Book Review RP BERLIN, RH (reprint author), SCH ADV MIL STUDIES,US ARMY COMMAND & GENERAL STAFF COLL,FT LEAVENWORTH,KS 66027, USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU UNIV CALIF PRESS PI BERKELEY PA JOURNALS DEPT 2120 BERKELEY WAY, BERKELEY, CA 94720 SN 0272-3433 J9 PUBL HISTORIAN JI Public Hist. PD SPR PY 1995 VL 17 IS 2 BP 100 EP 102 PG 3 WC History SC History GA RC314 UT WOS:A1995RC31400031 ER PT J AU BERLIN, RH AF BERLIN, RH TI UNITED-STATES MARINES IN VIETNAM - THE WAR THAT WOULD NOT END, 1971-1973 - MELSON,CD, ARNOLD,CG SO PUBLIC HISTORIAN LA English DT Book Review RP BERLIN, RH (reprint author), SCH ADV MIL STUDIES,US ARMY COMMAND & GENERAL STAFF COLL,FT LEAVENWORTH,KS 66027, USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU UNIV CALIF PRESS PI BERKELEY PA JOURNALS DEPT 2120 BERKELEY WAY, BERKELEY, CA 94720 SN 0272-3433 J9 PUBL HISTORIAN JI Public Hist. PD SPR PY 1995 VL 17 IS 2 BP 100 EP 102 PG 3 WC History SC History GA RC314 UT WOS:A1995RC31400030 ER PT J AU BERLIN, RH AF BERLIN, RH TI 1ST OFFENSIVE - THE MARINE CAMPAIGN FOR GUADALCANAL - SHAW,HI SO PUBLIC HISTORIAN LA English DT Book Review RP BERLIN, RH (reprint author), SCH ADV MIL STUDIES,US ARMY COMMAND & GENERAL STAFF COLL,FT LEAVENWORTH,KS 66027, USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU UNIV CALIF PRESS PI BERKELEY PA JOURNALS DEPT 2120 BERKELEY WAY, BERKELEY, CA 94720 SN 0272-3433 J9 PUBL HISTORIAN JI Public Hist. PD SPR PY 1995 VL 17 IS 2 BP 100 EP 102 PG 3 WC History SC History GA RC314 UT WOS:A1995RC31400029 ER PT J AU BERLIN, RH AF BERLIN, RH TI INFAMOUS DAY - MARINES AT PEARL-HARBOR, 7-DECEMBER-1941 - CRESSMAN,RJ, WENGER,MJ SO PUBLIC HISTORIAN LA English DT Book Review RP BERLIN, RH (reprint author), SCH ADV MIL STUDIES,US ARMY COMMAND & GENERAL STAFF COLL,FT LEAVENWORTH,KS 66027, USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU UNIV CALIF PRESS PI BERKELEY PA JOURNALS DEPT 2120 BERKELEY WAY, BERKELEY, CA 94720 SN 0272-3433 J9 PUBL HISTORIAN JI Public Hist. PD SPR PY 1995 VL 17 IS 2 BP 100 EP 102 PG 3 WC History SC History GA RC314 UT WOS:A1995RC31400028 ER PT J AU CHAPMAN, AW AF CHAPMAN, AW TI THE COAST-GUARD AND THE GREENLAND PATROL - TILLEY,JA SO PUBLIC HISTORIAN LA English DT Book Review RP CHAPMAN, AW (reprint author), OFFICE COMMAND HISTORIAN,US ARMY TRAINING & DOCTRINE COMMAND,FT MONROE,VA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CALIF PRESS PI BERKELEY PA JOURNALS DEPT 2120 BERKELEY WAY, BERKELEY, CA 94720 SN 0272-3433 J9 PUBL HISTORIAN JI Public Hist. PD SPR PY 1995 VL 17 IS 2 BP 102 EP 104 PG 3 WC History SC History GA RC314 UT WOS:A1995RC31400033 ER PT J AU CHAPMAN, AW AF CHAPMAN, AW TI THE COAST-GUARD AND THE WOMENS RESERVE IN WORLD-WAR-II - THOMSON,RJ SO PUBLIC HISTORIAN LA English DT Book Review RP CHAPMAN, AW (reprint author), OFFICE COMMAND HISTORIAN,US ARMY TRAINING & DOCTRINE COMMAND,FT MONROE,VA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CALIF PRESS PI BERKELEY PA JOURNALS DEPT 2120 BERKELEY WAY, BERKELEY, CA 94720 SN 0272-3433 J9 PUBL HISTORIAN JI Public Hist. PD SPR PY 1995 VL 17 IS 2 BP 102 EP 104 PG 3 WC History SC History GA RC314 UT WOS:A1995RC31400034 ER PT J AU CHAPMAN, AW AF CHAPMAN, AW TI COAST-GUARD-MANNED NAVAL VESSELS IN WORLD-WAR-II - JOHNSON,RE SO PUBLIC HISTORIAN LA English DT Book Review RP CHAPMAN, AW (reprint author), OFFICE COMMAND HISTORIAN,US ARMY TRAINING & DOCTRINE COMMAND,FT MONROE,VA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CALIF PRESS PI BERKELEY PA JOURNALS DEPT 2120 BERKELEY WAY, BERKELEY, CA 94720 SN 0272-3433 J9 PUBL HISTORIAN JI Public Hist. PD SPR PY 1995 VL 17 IS 2 BP 102 EP 104 PG 3 WC History SC History GA RC314 UT WOS:A1995RC31400032 ER PT J AU PERLSTEIN, RS MEHTA, NR MOUGEY, EH WHITNALL, MH NETA, R AF PERLSTEIN, RS MEHTA, NR MOUGEY, EH WHITNALL, MH NETA, R TI WHOLE-BODY IRRADIATION TRANSIENTLY DIMINISHES THE ADRENOCORTICOTROPIN RESPONSE TO RECOMBINANT HUMAN INTERLEUKIN-1-ALPHA SO RADIATION RESEARCH LA English DT Article ID TUMOR-NECROSIS-FACTOR; IONIZING-RADIATION; GENE-EXPRESSION; ACTH-SECRETION; CYTOKINES; INVIVO; CORTICOSTERONE; MODULATION; INHIBITION; RELEASE AB Recombinant human interleukin-1 alpha (rhIL-1 alpha) has significant potential as a radioprotector and/or treatment for radiation-induced hematopoietic injury. Both IL-1 and whole-body ionizing irradiation acutely stimulate the hypothalamic-pituitary-adrenal axis. We therefore assessed the interaction of whole-body irradiation and rhIL-1 alpha in altering the functioning of the axis in mice. Specifically, we determined the adrenocorticotropin (ACTH) and corticosterone responses to rhIL-1 alpha administered just before and hours to days after whole-body or sham irradiation. Our results indicate that whole-body irradiation does not potentiate the rhIL-1 alpha-induced increase in ACTH levels at the doses used. In fact, the rhIL-1 alpha-induced increase in plasma ACTH is transiently impaired when the cytokine is administered 5 h after, but not 1 h before, exposure to whole-body irradiation. The ACTH response may be inhibited by elevated corticosterone levels after whole-body irradiation, or by other radiation-induced effects on the pituitary gland and hypothalamus. (C) 1995 by Radiation Research Society C1 ARMED FORCES RADIOBIOL RES INST,DEPT PHYSIOL,BETHESDA,MD 20889. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT MED NEUROSCI,WASHINGTON,DC 20307. RP PERLSTEIN, RS (reprint author), ARMED FORCES RADIOBIOL RES INST,DEPT EXPTL HEMATOL,BETHESDA,MD 20889, USA. NR 36 TC 4 Z9 4 U1 0 U2 0 PU RADIATION RESEARCH SOC PI OAK BROOK PA 2021 SPRING RD, STE 600, OAK BROOK, IL 60521 SN 0033-7587 J9 RADIAT RES JI Radiat. Res. PD MAR PY 1995 VL 141 IS 3 BP 336 EP 341 DI 10.2307/3579013 PG 6 WC Biology; Biophysics; Radiology, Nuclear Medicine & Medical Imaging SC Life Sciences & Biomedicine - Other Topics; Biophysics; Radiology, Nuclear Medicine & Medical Imaging GA QH651 UT WOS:A1995QH65100014 PM 7871163 ER PT J AU MCADAMS, HP ROSADODECHRISTENSON, ML LESAR, M TEMPLETON, PA MORAN, CA AF MCADAMS, HP ROSADODECHRISTENSON, ML LESAR, M TEMPLETON, PA MORAN, CA TI THORACIC MYCOSES FROM ENDEMIC FUNGI - RADIOLOGIC-PATHOLOGICAL CORRELATION SO RADIOGRAPHICS LA English DT Article DE BLASTOMYCOSIS; COCCIDIOIDOMYCOSIS; HISTOPLASMOSIS; LUNG, INFECTION ID PULMONARY BLASTOMYCOSIS; DISSEMINATED HISTOPLASMOSIS; FIBROSING MEDIASTINITIS; CT; COCCIDIOIDOMYCOSIS; MANIFESTATIONS; INFECTIONS; DIAGNOSIS AB The endemic fungi Histoplasma capsulatum, Blastomyces dermatitidis and Coccidioides immitis are primary human pathogens whose major portal of entry is the respiratory tract, Their clinical manifestations are categorized as acute, chronic or chronic progressive, or disseminated fungal disease, Most acute pulmonary infections are self-limited, and many are asymptomatic, Chronic, progressive, or disseminated disease is much less common and most often occurs in immunocompromised patients, The radiologic manifestations of these disorders are protean, They include interstitial or air-space opacities, solitary or multiple pulmonary nodules, parenchymal masses, cavities, and hilar or mediastinal adenopathy, The diagnosis of a thoracic mycosis requires familiarity with the epidemiology of the fungus in question, the various modes of clinical presentation, and the full spectrum of radiologic manifestations, Although skin and serologic tests can be useful, definitive diagnosis requires culture of the fungus from infected tissue or demonstration of the organism at microscopic examination. C1 WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL & NUCL MED,BETHESDA,MD 20814. ARMED FORCES INST PATHOL,DEPT RADIOL PATHOL,WASHINGTON,DC 20306. ARMED FORCES INST PATHOL,DEPT PULM & MEDIASTINAL PATHOL,WASHINGTON,DC 20306. UNIV MARYLAND,MED SYST,DEPT RADIOL,BALTIMORE,MD 21201. RI McAdams, Holman/N-8218-2015 OI McAdams, Holman/0000-0002-7044-3320 NR 29 TC 15 Z9 15 U1 0 U2 0 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0271-5333 J9 RADIOGRAPHICS JI Radiographics PD MAR PY 1995 VL 15 IS 2 BP 255 EP 270 PG 16 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA QM398 UT WOS:A1995QM39800001 PM 7761632 ER PT J AU MCADAMS, HP ROSADODECHRISTENSON, ML TEMPLETON, PA LESAR, M MORAN, CA AF MCADAMS, HP ROSADODECHRISTENSON, ML TEMPLETON, PA LESAR, M MORAN, CA TI THORACIC MYCOSES FROM OPPORTUNISTIC FUNGI - RADIOLOGIC-PATHOLOGICAL CORRELATION SO RADIOGRAPHICS LA English DT Article DE ASPERGILLOSIS; CANDIDIASIS; CRYPTOCOCCOSIS; LUNG, INFECTION ID INVASIVE PULMONARY ASPERGILLOSIS; ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS; AIR CRESCENT SIGN; ACUTE-LEUKEMIA; CANDIDA-ALBICANS; EARLY DIAGNOSIS; SPECTRUM; INFECTIONS; CT; CRYPTOCOCCOSIS AB Fungi of the genera Aspergillus, Candida, and Cryptococcus and the class Zygomycetes are the most common causes of thoracic opportunistic mycoses in immunocompromised patients. Candidiasis and zygomycosis usually manifest as severe, often life-threatening, pneumonias, Aspergillus species are commonly implicated as the causative organisms in a broad spectrum of pulmonary disorders, ranging from hypersensitivity lung disease in atopic patients to invasive pneumonia in immunocompromised patients, Cryptococcus neoformans infects both immunologically normal and abnormal patients, with variable clinical and radiologic findings, The diagnosis of an opportunistic mycosis requires familiarity with the epidemiology of the disease, the various modes of clinical presentation, and the full spectrum of radiologic manifestations; Because many of these fungi mar normally colonize in the upper respiratory tract, sputum cultures are considered diagnostically unreliable, Instead, definitive diagnosis hinges on either culture of the fungus from infected tissue or demonstration of the organism at microscopic examination. C1 WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL & NUCL MED,BETHESDA,MD 20814. ARMED FORCES INST PATHOL,DEPT RADIOL PATHOL,WASHINGTON,DC 20306. ARMED FORCES INST PATHOL,DEPT PULM & MEDIASTINAL PATHOL,WASHINGTON,DC 20306. UNIV MARYLAND,MED SYST,DEPT RADIOL,BALTIMORE,MD 21201. RI McAdams, Holman/N-8218-2015 OI McAdams, Holman/0000-0002-7044-3320 NR 42 TC 24 Z9 27 U1 0 U2 0 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0271-5333 J9 RADIOGRAPHICS JI Radiographics PD MAR PY 1995 VL 15 IS 2 BP 271 EP 286 PG 16 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA QM398 UT WOS:A1995QM39800002 PM 7761633 ER PT J AU WALKER, J GARSTER, J AF WALKER, J GARSTER, J TI DIFFERENTIAL GPS - REVOLUTIONING CORPS APPLICATIONS SO SEA TECHNOLOGY LA English DT Article C1 USA,CTR TOPOG ENGN,FT BELVOIR,VA. NR 6 TC 1 Z9 1 U1 0 U2 0 PU COMPASS PUBL INC PI ARLINGTON PA SUITE 1000 1117 N 19 ST, ARLINGTON, VA 22209 SN 0093-3651 J9 SEA TECHNOL JI Sea Technol. PD MAR PY 1995 VL 36 IS 3 BP 29 EP & PG 0 WC Engineering, Ocean SC Engineering GA QM913 UT WOS:A1995QM91300004 ER PT J AU DELOACH, S SHANNON, B WELLS, DE DODD, D AF DELOACH, S SHANNON, B WELLS, DE DODD, D TI DELINEATION OF TIDAL DATUMS, WATER-SURFACE SLOPES WITH GPS SO SEA TECHNOLOGY LA English DT Article C1 USA,CTR TOPOGR ENGN,DIV SURVEYING,FT BELVOIR,VA. UNIV NEW BRUNSWICK,DEPT GEODESY & GEOMAT ENGN,FREDERICTON,NB E3B 5A3,CANADA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU COMPASS PUBL INC PI ARLINGTON PA SUITE 1000 1117 N 19 ST, ARLINGTON, VA 22209 SN 0093-3651 J9 SEA TECHNOL JI Sea Technol. PD MAR PY 1995 VL 36 IS 3 BP 56 EP 60 PG 5 WC Engineering, Ocean SC Engineering GA QM913 UT WOS:A1995QM91300008 ER PT J AU REDMOND, J SAMHA, MA CHARLES, RS VUKELJA, SJ FARAGHER, D TENGLIN, R REID, T DAWSON, N AUERBACH, H RICHTER, MP AF REDMOND, J SAMHA, MA CHARLES, RS VUKELJA, SJ FARAGHER, D TENGLIN, R REID, T DAWSON, N AUERBACH, H RICHTER, MP TI BILATERAL SYNCHRONOUS TESTICULAR GERM-CELL CANCER SO SOUTHERN MEDICAL JOURNAL LA English DT Article ID CONTRALATERAL TESTIS; CARCINOMA INSITU; TUMORS; RISK AB Bilateral synchronous testicular cancer is a rare occurrence usually associated with similar histologic findings in each testicle. We describe eight patients with bilateral synchronous testicular germ cell cancer, of whom four had dissimilar histologic findings. Contralateral disease in three patients was identified only by testicular ultrasonography or intraoperative exploration of the contralateral testicle, and in two cases by palpation 6 months after identification of the primary cancer. Treatment was determined by conventional staging and five of eight patients have remained free of recurrent disease. C1 ABINGTON MEM HOSP,DEPT UROL,ABINGTON,PA 19001. ABINGTON MEM HOSP,DEPT PATHOL,ABINGTON,PA 19001. ABINGTON MEM HOSP,DEPT RADIAT ONCOL,ABINGTON,PA 19001. BROOKE ARMY MED CTR,DEPT MED,SAN ANTONIO,TX. FITZSIMONS ARMY MED CTR,DEPT MED,AURORA,CO 80045. MADIGAN ARMY MED CTR,DEPT MED,TACOMA,WA 98431. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. RP REDMOND, J (reprint author), ABINGTON MEM HOSP,DEPT MED,DIV MED ONCOL,ABINGTON,PA 19001, USA. NR 18 TC 9 Z9 9 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD MAR PY 1995 VL 88 IS 3 BP 305 EP 308 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA QK962 UT WOS:A1995QK96200011 PM 7886527 ER PT J AU RAY, R LEGERE, RH MAJERUS, BJ PETRALI, JP AF RAY, R LEGERE, RH MAJERUS, BJ PETRALI, JP TI SULFUR MUSTARD-INDUCED INCREASE IN INTRACELLULAR FREE CALCIUM LEVEL AND ARACHIDONIC-ACID RELEASE FROM CELL-MEMBRANE SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article ID NAD+ LEVELS; PC12 CELLS; RAT-LIVER; PHOSPHOLIPASE-A2; NICOTINAMIDE; LYMPHOCYTES; MECHANISMS; RECEPTORS; EXPOSURE; TURNOVER AB The mechanism of action of the alkylating agent bis-(2-chloroethyl)sulfide (sulfur mustard, SM) was studied using the in vitro mouse neuroblastoma-rat glioma hybrid NG108-15 clonal cell line model. Following 0.3 mM SM exposure, cell viability remained high (>80% of untreated control) up to 9 hr and then declined steadily to about 40% of control after 20-24 hr. During the early period of SM exposure, when there was no significant cell viability loss, the following effects were observed. The cellular glutathione level decreased 20% after 1 hr and 34% after 6 hr. Between 2 and 6 hr, there was a time-dependent increase (about 10 to 30%) in intracellular free calcium (Ca2+), which was localized to the limiting membrane of swollen endoplasmic reticula and mitochondria, to euchromatin areas of the nucleus, and to areas of the cytosol and plasma membrane. Moreover, there was also a time-dependent increase in the release of isotopically labeled arachidonic acid ([H-3]AA) from cellular membranes. Increase in [H-3]AA release was 28% at 3 hr and about 60-80% between 6 and 9 hr. This increase in [H-3]AA release was inhibited by quinacrine (20 mu M), which is a phospholipase (PLA(2)) inhibitor. At 16 hr after SM exposure, there was a large increase (about 200% of control) in [H-3]AA release, which was coincident with a 50% loss of cell viability. These results suggest a Ca2+-mediated toxic mechanism of SM via PLA(2) activation and arachidonate release. (C) 1995 Academic Press, Inc. C1 USA,MED RES INST CHEM DEF,COMPARAT PATHOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. RP RAY, R (reprint author), USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 38 TC 46 Z9 46 U1 0 U2 3 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD MAR PY 1995 VL 131 IS 1 BP 44 EP 52 DI 10.1006/taap.1995.1045 PG 9 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA QK940 UT WOS:A1995QK94000006 PM 7878677 ER PT J AU KINKEAD, ER WOLFE, RE SALINS, SA FLEMMING, CD LEAHY, HF CALDWELL, DJ MILLER, CR MARIT, GB AF KINKEAD, ER WOLFE, RE SALINS, SA FLEMMING, CD LEAHY, HF CALDWELL, DJ MILLER, CR MARIT, GB TI GENERAL TOXICITY AND REPRODUCTIVE SCREEN OF LIQUID PROPELLANT XM46 ADMINISTERED IN THE DRINKING-WATER OF SPRAGUE-DAWLEY RATS SO TOXICOLOGY AND INDUSTRIAL HEALTH LA English DT Article DE DRINKING WATER; HEMOLYTIC ANEMIA; LIQUID PROPELLANT; NITRATE; REPRODUCTIVE SCREEN; SPRAGUE-DAWLEY RAT; XM46 AB Liquid propellant XM46 is being considered as a replacement for solid propellants, both as part of a regenerative injection gun system and as a working fluid in an electrothermal gun system. The XM46 formulation contains hydroxylammonium nitrate, triethanolammonium nitrate, and water. Male and female Sprague-Dawley rats received XM46 in drinking water containing 2.0, 1.0, 0.2, or 0.0 g XM46/liter throughout a 90-day study. Mating occurred following 14 days of treatment. One-half the male rats per group were necropsied after 28 days of treatment; the remaining males and all dams were necropsied following 90 days of treatment. No mortality occurred in any of the parental animals during the study. The study did not demonstrate any adverse effects on reproduction or litter parameters. Hemolytic anemia and methemoglobinemia were common in both sexes of rats. Splenomegaly was found in both sexes; in male rats as early as 28 days. Exposures via drinking water containing XM46 for 90 days did not result in any decrease in reproductive performance in male or female rats, but it did result in clinical signs of hemolytic anemia at doses as low as 17 mg/kg/day. C1 USA,MED RES DETACHMENT,WALTER REED ARMY INST RES,WRIGHT PATTERSON AFB,OH. ARMSTRONG LAB,DIV TOXICOL,OCCUPAT & ENVIRONM HLTH DIRECTORATE,WRIGHT PATTERSON AFB,OH. RP KINKEAD, ER (reprint author), MANTECH ENVIRONM TECHNOL INC,POB 31009,DAYTON,OH 45437, USA. NR 27 TC 3 Z9 9 U1 0 U2 1 PU PRINCETON SCIENTIFIC PUBL INC PI PRINCETON PA PO BOX 2155, PRINCETON, NJ 08543 SN 0748-2337 J9 TOXICOL IND HEALTH JI Toxicol. Ind. Health PD MAR-APR PY 1995 VL 11 IS 2 BP 199 EP 215 PG 17 WC Public, Environmental & Occupational Health; Toxicology SC Public, Environmental & Occupational Health; Toxicology GA RH360 UT WOS:A1995RH36000007 PM 7491635 ER PT J AU TSAI, MC HSIEH, WH SMITH, LA LEE, CY AF TSAI, MC HSIEH, WH SMITH, LA LEE, CY TI EFFECTS OF WAGLERIN-I ON NEUROMUSCULAR-TRANSMISSION OF MOUSE NERVE-MUSCLE PREPARATIONS SO TOXICON LA English DT Article ID TRIMERESURUS-WAGLERI; PIT VIPER; LETHAL PEPTIDES; TERMINALS; VENOM; CURRENTS AB The effects of waglerin-I, a toxin from Trimeresurus wagleri, on neuromuscular (NM) transmission were studied on the phrenic nerve-diaphragm preparation and triangularis sterni nerve-muscle preparation of mice. The toxin (1.2-4.0 mu M) reversibly inhibited the indirectly elicited twitch tension of the diaphragm and decreased the ACh-elicited muscle contracture of chronically denervated diaphragm, while the directly elicited twitch tension was not affected. The toxin reversibly decreased the amplitude of miniature endplate potential (MEPP) at 0.52 mu M and endplate potential (EPP) at 1.2-4 nM. The toxin (120 nM-0.4 mu M) also decreased the quantal content of EPP. The perineural waveforms were recorded with an extracellular electrode placed into the perineural sheaths of motor nerves of M. triangularis sterni. The toxin (4 mu M) did not alter the amplitudes of waveforms related to sodium and potassium currents of the nerve terminal action potential, while the waveform related to calcium current was decreased. It is concluded that the toxin acts on both presynaptic and postsynaptic sires of the mouse motor endplate, and that the presynaptic effect is apparently more potent than the postsynaptic effect. C1 USA,MED RES INST INFECT DIS,FT DETRICK,MD 21701. RP TSAI, MC (reprint author), NATL TAIWAN UNIV,COLL MED,DEPT PHARMACOL,JEN AI RD,TAIPEI 10018,TAIWAN. NR 13 TC 16 Z9 16 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD MAR PY 1995 VL 33 IS 3 BP 363 EP 371 DI 10.1016/0041-0101(94)00158-5 PG 9 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA QU466 UT WOS:A1995QU46600008 PM 7638875 ER PT J AU TAKEUCHI, H MOHRI, M SHIRAKI, K LIN, YC CLAYBAUGH, JR HONG, SK AF TAKEUCHI, H MOHRI, M SHIRAKI, K LIN, YC CLAYBAUGH, JR HONG, SK TI DIURNAL RENAL RESPONSES IN MAN TO WATER LOADING AT SEA-LEVEL AND 31-ATM-ABS SO UNDERSEA AND HYPERBARIC MEDICINE LA English DT Article DE CUMULATIVE URINE OUTPUT; VASOPRESSIN; CIRCADIAN RHYTHM; ALDOSTERONE ID DRY SATURATION DIVE; SEADRAGON-VI; 31-ATA; DIURESIS; BALANCE; HUMANS; NIGHT AB The hyperbaric environment causes a sustained diuresis accompanied by normal water intake and a decrease in insensible water loss. The maintained water intake may be necessary for the maintenance of water balance because of a reduced ability of the kidney to retain water, or may be causal in the diuresis. This problem was studied in four male subjects. Each ingested 1 liter of water (15 degrees C) at 0800 and 2000 h on different days, at 1 atm abs during a predive control, at 31 atm abs, and at 1 atm abs during the postdive control period. Urine was collected 30 min before and 3 h after the drink. Plasma vasopressin (VP) showed a circadian rhythm only at 1 atm abs, higher during the daytime. Because of this, and slightly lower VP levels at hyperbaria, a decrease in VP in response to the water load was significantly detectable only at 1 atm abs during the daytime. At 60 min after all water loads, there were no differences in plasma VP or plasma or urinary osmolality. Variability in the length of time of similarly reduced urine osmolality and increased free water excretion accounted for the increased urine flow during day compared to night (P < 0.05) at 120 and 150 min after the water load. The ability to excrete a water load both day (free water clear-ance, P < 0.05 at 60 min post-drink) and night (free water clearance, P < 0.05 at 60, 90, and 120 min post-drink) at 31 atm abs was enhanced. It is concluded that maintained water intake at hyperbaria is necessary to maintain water balance because there is a reduced ability of the body through renal mechanisms to retain a water load. C1 JAPAN MARINE SCI & TECHNOL CTR, YOKOSUKA, KANAGAWA, JAPAN. UNIV HAWAII, HONOLULU, HI 96822 USA. TRIPLER ARMY MED CTR, HONOLULU, HI 96859 USA. SUNY BUFFALO, BUFFALO, NY 14214 USA. RP TAKEUCHI, H (reprint author), UNIV OCCUPAT & ENVIRONM HLTH, DEPT PHYSIOL, NISHI KU, 1-1 ISEIGAOKA, KITAKYUSHU, FUKUOKA 807, JAPAN. FU NHLBI NIH HHS [HL-28542] NR 15 TC 5 Z9 5 U1 0 U2 1 PU UNDERSEA & HYPERBARIC MEDICAL SOC INC PI DURHAM PA 21 WEST COLONY PLACE, STE 280, DURHAM, NC 27705 USA SN 1066-2936 J9 UNDERSEA HYPERBAR M JI Undersea Hyperb. Med. PD MAR PY 1995 VL 22 IS 1 BP 61 EP 71 PG 11 WC Marine & Freshwater Biology; Medicine, Research & Experimental SC Marine & Freshwater Biology; Research & Experimental Medicine GA QH659 UT WOS:A1995QH65900008 PM 7742711 ER PT J AU KOTULAK, JC MORSE, SE AF KOTULAK, JC MORSE, SE TI THE EFFECT OF PERCEIVED DISTANCE ON ACCOMMODATION UNDER BINOCULAR STEADY-STATE CONDITIONS SO VISION RESEARCH LA English DT Article DE ACCOMMODATION; PERCEIVED DISTANCE; BINOCULAR VISION; AUTOSTEREOGRAM ID ADAPTATION; LUMINANCE; VERGENCE; CUES AB Spatiotopic cues, such as perceived distance, have little effect on accommodation unless blur has been reduced or eliminated, We investigated the effect of perceived distance on accommodation under binocular steady-state conditions, about which little is known. Blur was reduced but not eliminated by using a stimulus with a moderately low luminance, Accommodation was measured under two conditions: (I) when cues from perceived distance, blur, and convergence were aligned; and (2) when perceived distance was opposed by both blur and convergence. We found a significant difference in accommodation between the two conditions, which we attribute to perceived distance. RP KOTULAK, JC (reprint author), USA,AEROMED RES LAB,VISUAL SCI BRANCH,POB 620577,FT RUCKER,AL 36362, USA. NR 28 TC 11 Z9 11 U1 0 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0042-6989 J9 VISION RES JI Vision Res. PD MAR PY 1995 VL 35 IS 6 BP 791 EP 795 DI 10.1016/0042-6989(94)00157-H PG 5 WC Neurosciences; Ophthalmology SC Neurosciences & Neurology; Ophthalmology GA QK904 UT WOS:A1995QK90400006 PM 7740770 ER PT J AU DUMAIS, RE YOUNG, KC AF DUMAIS, RE YOUNG, KC TI USING A SELF-LEARNING ALGORITHM FOR SINGLE-STATION QUANTITATIVE PRECIPITATION FORECASTING IN GERMANY SO WEATHER AND FORECASTING LA English DT Article AB A self-learning algorithm called goal-oriented pattern detection was used to develop a set of 12 models designed to forecast 24-h precipitation amounts for eight sites in southern Germany. The forecasts of expected precipitation amount valid for the following 24-h period are issued shortly after 0000 UTC each day and are based on the available rawinsonde data from the current 0000 UTC and previous 1200 UTC observations. The period 1973-1982 was used for developing the forecast models, and the year 1983 was used for verification purposes. The forecast models provide the probability of precipitation greater than any specified amount at each of the eight stations. The overall skill score (percentage reduction in the squared forecast error compared to climatology) for 1983 over five forecast amounts was 31%. The forecast skill for measurable precipitation was 37% and decreased with increasing precipitation amounts to 19% for amounts greater than or equal to 0.20 in. The forecast model executes on an MS-DOS-based personal computer and provides the probability of precipitation greater than any specified amount or specifies the amount of precipitation associated with any given risk level. These values can be shown in tabular form for each station or displayed as a contour map over the region of interest. C1 UNIV ARIZONA,INST ATMOSPHER PHYS,TUCSON,AZ. RP DUMAIS, RE (reprint author), USA,RES LAB,AMSRL BE W,BATTLEFIELD ENVIRONM DIRECTORATE,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 13 TC 3 Z9 3 U1 0 U2 0 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 SN 0882-8156 J9 WEATHER FORECAST JI Weather Forecast. PD MAR PY 1995 VL 10 IS 1 BP 105 EP 113 DI 10.1175/1520-0434(1995)010<0105:UASLAF>2.0.CO;2 PG 9 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA QU385 UT WOS:A1995QU38500008 ER PT J AU STRUTHWOLF, ME AF STRUTHWOLF, ME TI FORECASTING MAXIMUM TEMPERATURES THROUGH USE OF AN ADJUSTED 850-MB TO 700-MB THICKNESS TECHNIQUE SO WEATHER AND FORECASTING LA English DT Note AB A new technique is discussed for forecasting maximum daily surface temperatures at Dugway Proving Ground (DPG), Utah, a non-MOS site, using real-time surface data and the adjusted 850- to 700-mb thickness from 1200 UTC radiosonde profiles. Based on the hypsometric equation, this technique is easily computed, is less influenced by climatology, and allows the forecaster to weigh the various parameters influencing each forecast. The technique requires that empirical best-fit relationships between maximum temperature and the 1200 UTC 850- to 700-mb thickness be established by month for various sky conditions. These relationships are further adjusted and refined by empirical rules that account for thermal advection at 700 mb, state of ground, surface pressure, and surface wind circulations. As a result, this adjusted thickness technique has been used successfully at DPG to accurately forecast days ranging from ones with temperatures near the climatological average to ones with an extreme departure from average. Forecasters at DPG expressed greater confidence in their maximum temperature forecasts using this adjusted thickness technique. While only demonstrated at DPG, it has potential use elsewhere. C1 USA,DIV METEOROL,DUGWAY PROVING GROUND,UT. NR 10 TC 2 Z9 2 U1 0 U2 0 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 SN 0882-8156 J9 WEATHER FORECAST JI Weather Forecast. PD MAR PY 1995 VL 10 IS 1 BP 160 EP 171 DI 10.1175/1520-0434(1995)010<0160:FMTTUO>2.0.CO;2 PG 12 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA QU385 UT WOS:A1995QU38500012 ER PT J AU JAGLOWSKI, AJ SINGLER, RE ATKINS, EDT AF JAGLOWSKI, AJ SINGLER, RE ATKINS, EDT TI LIQUID-CRYSTALLINE BEHAVIOR OF POLY[((6-(4-PHENYLPHENOXY)HEXYL)OXY)(TRIFLUOROETHOXY)PHOSPHAZENE] SO MACROMOLECULES LA English DT Article ID SIDE GROUPS; PHOSPHAZENES AB The thermotropic liquid crystalline behavior of a mixed-substituent poly(organophosphazene) containing trifluoroethoxy and (6-(4-phenylphenoxy)hexyl)oxy side chain groups has been investigated by differential scanning calorimetry, polarized optical microscopy, and X-ray diffraction. Upon cooling from the isotropic Liquid a ''batonnet'' texture mesophase formed, which is indicative of a smectic-like structure as compared to low molar mass molecules. The texture grows and coalesces to a final texture. The X-ray diffraction pattern of the ''captured'' structure upon quench-cooling from the mesophase indicated a mixture of smectic C- and A-like phases. The phosphazene backbone layer thickness is approximately 2.4 mo, and the mesogenic (6-(4-phenylphenoxy)hexyl) oxy side chain overlaps in an antiparallel, interdigitated structure within this layered interval. Mesophase formation in the mixed-substituent polyphosphazene is due largely to the chemical inhomogeneity of the side chain groups, since the single-substituent polyphosphazene containing the same biphenyl side chain does not exhibit a liquid crystalline phase. C1 USA,RES LAB,POLYMER RES BRANCH,WATERTOWN,MA 02172. UNIV BRISTOL,HH WILLS PHYS LAB,BRISTOL BS8 1TL,AVON,ENGLAND. NR 13 TC 32 Z9 33 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD FEB 27 PY 1995 VL 28 IS 5 BP 1668 EP 1672 DI 10.1021/ma00109a045 PG 5 WC Polymer Science SC Polymer Science GA QK081 UT WOS:A1995QK08100045 ER PT J AU HAMMACK, J MCCALLISTER, D SCHEFFNER, N SEGUR, H AF HAMMACK, J MCCALLISTER, D SCHEFFNER, N SEGUR, H TI 2-DIMENSIONAL PERIODIC-WAVES IN SHALLOW-WATER .2. ASYMMETRIC WAVES SO JOURNAL OF FLUID MECHANICS LA English DT Article AB We demonstrate experimentally the existence of a family of gravity-induced finite-amplitude water waves that propagate practically without change of form in shallow water of uniform depth. The surface patterns of these waves are genuinely two-dimensional, and periodic. The basic template of a wave is hexagonal, but it need not be symmetric about the direction of propagation, as required in our previous studies (e.g. Hammack et al. 1989). Like the symmetric waves in earlier studies, the asymmetric waves studied here are easy to generate, they seem to be stable to perturbations, and their amplitudes need not be small. The Kadomtsev-Petviashvili (KP) equation is known to describe approximately the evolution of waves in shallow water, and an eight-parameter family of exact solutions of this equation ought to describe almost all spatially periodic waves of permanent form. We present an algorithm to obtain the eight parameters from wave-gauge measurements. The resulting KP solutions are observed to describe the measured waves with reasonable accuracy, even outside the putative range of validity of the KP model. C1 PENN STATE UNIV,DEPT MATH,UNIVERSITY PK,PA 16802. UNIV COLORADO,PROGRAM APPL MATH,BOULDER,CO 80309. USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,VICKSBURG,MS 39180. RP HAMMACK, J (reprint author), PENN STATE UNIV,DEPT GEOSCI,UNIVERSITY PK,PA 16802, USA. NR 18 TC 51 Z9 51 U1 0 U2 3 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 40 WEST 20TH STREET, NEW YORK, NY 10011-4211 SN 0022-1120 J9 J FLUID MECH JI J. Fluid Mech. PD FEB 25 PY 1995 VL 285 BP 95 EP 122 DI 10.1017/S0022112095000474 PG 28 WC Mechanics; Physics, Fluids & Plasmas SC Mechanics; Physics GA QK091 UT WOS:A1995QK09100005 ER PT J AU WRABACK, M SHEN, H PAMULAPATI, J NEWMAN, PG DUTTA, M AF WRABACK, M SHEN, H PAMULAPATI, J NEWMAN, PG DUTTA, M TI POLARIZATION-DEPENDENT EXCITONIC OPTICAL NONLINEARITIES IN GAAS/ALGAAS MULTIPLE-QUANTUM WELLS UNDER ANISOTROPIC INPLANE STRAIN SO PHYSICAL REVIEW LETTERS LA English DT Article ID UNIAXIAL-STRESS; BLUE SHIFT; SUBBANDS RP WRABACK, M (reprint author), USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,AMSRL EP EF,FT MONMOUTH,NJ 07703, USA. NR 18 TC 12 Z9 12 U1 0 U2 2 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD FEB 20 PY 1995 VL 74 IS 8 BP 1466 EP 1469 DI 10.1103/PhysRevLett.74.1466 PG 4 WC Physics, Multidisciplinary SC Physics GA QH293 UT WOS:A1995QH29300053 ER PT J AU PEARTON, SJ ABERNATHY, CR MACKENZIE, JD WILSON, RG REN, F ZAVADA, JM AF PEARTON, SJ ABERNATHY, CR MACKENZIE, JD WILSON, RG REN, F ZAVADA, JM TI THERMAL-STABILITY OF DEUTERIUM IN INALN AND INALGAN SO ELECTRONICS LETTERS LA English DT Article DE INDIUM COMPOUNDS; PLASMA DEPOSITION AB Deuterium concentrations of greater than or equal to 10(21) cm(-3) can be introduced into epitaxial InAlN and InAlGaN by plasma exposure at 250 degrees C. This produces a decrease of approximately a factor of 10 in the n-type carrier concentration in these materials, but can be reversed by annealing at similar to 500 degrees C. Reactivation occurs with an apparent activation energy of similar to 2.4 eV. Annealing at 900 degrees C is required to remove > 90% of the deuterium from both nitride materials. C1 HUGHES RES LABS,MALIBU,CA 90265. AT&T BELL LABS,MURRAY HILL,NJ 07974. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP PEARTON, SJ (reprint author), UNIV FLORIDA,DEPT MAT SCI & ENGN,GAINESVILLE,FL 32611, USA. NR 8 TC 4 Z9 4 U1 0 U2 8 PU IEE-INST ELEC ENG PI HERTS PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTS, ENGLAND SG1 2AY SN 0013-5194 J9 ELECTRON LETT JI Electron. Lett. PD FEB 16 PY 1995 VL 31 IS 4 BP 327 EP 329 DI 10.1049/el:19950194 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA QL564 UT WOS:A1995QL56400060 ER PT J AU CHO, PS GOLDHAR, J LEE, CH SADDOW, SE NEUDECK, P AF CHO, PS GOLDHAR, J LEE, CH SADDOW, SE NEUDECK, P TI PHOTOCONDUCTIVE AND PHOTOVOLTAIC RESPONSE OF HIGH-DARK-RESISTIVITY 6H-SIC DEVICES SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SILICON-CARBIDE; DIAMOND C1 WEAPONS TECHNOL DIRECTORATE,ARMY RES LAB,ADELPHI,MD 20783. NASA,LEWIS RES CTR,CLEVELAND,OH 44135. RP CHO, PS (reprint author), UNIV MARYLAND,DEPT ELECT ENGN,COLLEGE PK,MD 20742, USA. NR 30 TC 16 Z9 22 U1 0 U2 7 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD FEB 15 PY 1995 VL 77 IS 4 BP 1591 EP 1599 DI 10.1063/1.358912 PG 9 WC Physics, Applied SC Physics GA QG500 UT WOS:A1995QG50000036 ER PT J AU SHADRIN, VD MITIN, VV KOCHELAP, VA CHOI, KK AF SHADRIN, VD MITIN, VV KOCHELAP, VA CHOI, KK TI PHOTOCONDUCTIVE GAIN AND GENERATION-RECOMBINATION NOISE IN QUANTUM-WELL INFRARED PHOTODETECTORS SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID DETECTORS C1 WAYNE STATE UNIV,DEPT ELECT & COMP ENGN,DETROIT,MI 48202. USA,RES LAB,EPSD,FT MONMOUTH,NJ 07703. NR 14 TC 20 Z9 20 U1 0 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD FEB 15 PY 1995 VL 77 IS 4 BP 1771 EP 1775 DI 10.1063/1.358873 PG 5 WC Physics, Applied SC Physics GA QG500 UT WOS:A1995QG50000068 ER PT J AU BARTH, J AF BARTH, J TI HOW TO BUY STOCKS THE SMART WAY - LITTAUER,S SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD FEB 15 PY 1995 VL 120 IS 3 BP 164 EP 165 PG 2 WC Information Science & Library Science SC Information Science & Library Science GA QG429 UT WOS:A1995QG42900085 ER PT J AU HOLMSTROM, SA TAHERI, B REEVES, RJ POWELL, RC SHARP, EJ NEURGOANKAR, RR AF HOLMSTROM, SA TAHERI, B REEVES, RJ POWELL, RC SHARP, EJ NEURGOANKAR, RR TI NONLINEAR-OPTICAL RESPONSES OF STRONTIUM BARIUM NIOBATE SO OPTICS COMMUNICATIONS LA English DT Note ID PHOTOREFRACTIVE PROPERTIES; LIGHT-PULSES; BSO; GRATINGS; HOLOGRAPHY; ABSORPTION; BUILDUP; DECAY AB Single laser light pulses were used to induce gratings in nominally undoped and iron-doped Sr0.60Ba0.40Nb2O6 (SBN:60) using, in separate experiments, both 22 ps (lambda = 532 nm) and 400 fs (lambda = 580 nm) pulses. In both cases the gratings appear to have at least two temporal components outside the cross correlation time scale of the pulses. The first component is shown to be associated with induced absorption at the probe wavelength while a photorefractive grating associated with the displacement of charge carriers explains the second. The two-photon absorption coefficient, beta, was measured to be 2.3 cm/GW (lambda = 532 nm) and 2.0 cm/GW (lambda = 580 nm) for the undoped sample and 2.15 cm/GW (lambda = 532 nm) for the iron-doped sample. C1 OKLAHOMA STATE UNIV,DEPT PHYS,STILLWATER,OK 74078. OKLAHOMA STATE UNIV,CTR LASER RES,STILLWATER,OK 74078. USA,RES LAB,FT BELVOIR,VA 22060. ROCKWELL INT SCI CTR,THOUSAND OAKS,CA 91360. NR 22 TC 3 Z9 3 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD FEB 15 PY 1995 VL 114 IS 5-6 BP 413 EP 420 DI 10.1016/0030-4018(94)00629-9 PG 8 WC Optics SC Optics GA QG578 UT WOS:A1995QG57800009 ER PT J AU YU, SG KIM, KW STROSCIO, MA IAFRATE, GJ AF YU, SG KIM, KW STROSCIO, MA IAFRATE, GJ TI ELECTRON ACOUSTIC-PHONON SCATTERING RATES IN CYLINDRICAL QUANTUM WIRES SO PHYSICAL REVIEW B LA English DT Note ID BRILLOUIN-SCATTERING; RAMAN-SCATTERING; FILMS; MODES C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. N CAROLINA STATE UNIV,DEPT PHYS,RALEIGH,NC 27695. RP YU, SG (reprint author), N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695, USA. NR 17 TC 47 Z9 47 U1 0 U2 0 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD FEB 15 PY 1995 VL 51 IS 7 BP 4695 EP 4698 DI 10.1103/PhysRevB.51.4695 PG 4 WC Physics, Condensed Matter SC Physics GA QH869 UT WOS:A1995QH86900094 ER PT J AU ZHOU, WM SHEN, H PAMULAPATI, J COOKE, P DUTTA, M AF ZHOU, WM SHEN, H PAMULAPATI, J COOKE, P DUTTA, M TI HEAVY-HOLE AND LIGHT-HOLE BAND CROSSING IN A VARIABLE-STRAIN QUANTUM-WELL HETEROSTRUCTURE SO PHYSICAL REVIEW B LA English DT Note ID SEMICONDUCTORS; SUPERLATTICE; STATES C1 GEOCENTERS INC,LAKE HOPATCONG,NJ 07849. RP ZHOU, WM (reprint author), USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703, USA. NR 15 TC 1 Z9 1 U1 0 U2 0 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD FEB 15 PY 1995 VL 51 IS 8 BP 5461 EP 5464 DI 10.1103/PhysRevB.51.5461 PG 4 WC Physics, Condensed Matter SC Physics GA QP758 UT WOS:A1995QP75800093 ER PT J AU SIMION, BM THOMAS, G RAMESH, R KERAMIDAS, VG PFEFFER, RL AF SIMION, BM THOMAS, G RAMESH, R KERAMIDAS, VG PFEFFER, RL TI GROWTH AND CHARACTERIZATION OF (Y3FE5O12-BI3FE5O12) HETEROSTRUCTURES BY PULSED-LASER DEPOSITION SO APPLIED PHYSICS LETTERS LA English DT Article ID IRON-GARNET FILMS C1 UNIV CALIF BERKELEY,LAWRENCE BERKELEY LAB,DIV MAT SCI,BERKELEY,CA 94720. BELL COMMUN RES INC,RED BANK,NJ 07701. USA,RES LAB,FT MONMOUTH,NJ 07701. RP SIMION, BM (reprint author), UNIV CALIF BERKELEY,DEPT MAT SCI & ENGN,BERKELEY,CA 94720, USA. NR 7 TC 16 Z9 16 U1 1 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD FEB 13 PY 1995 VL 66 IS 7 BP 830 EP 832 DI 10.1063/1.113436 PG 3 WC Physics, Applied SC Physics GA QG232 UT WOS:A1995QG23200018 ER PT J AU RONALD, MG BLANCK, R HIATT, J HYAMS, KC KANG, H MATHER, S MURPHY, F ROSWELL, R THACKER, SB AF RONALD, MG BLANCK, R HIATT, J HYAMS, KC KANG, H MATHER, S MURPHY, F ROSWELL, R THACKER, SB TI UNEXPLAINED ILLNESSES AMONG DESERT-STORM VETERANS - A SEARCH FOR CAUSES, TREATMENT, AND COOPERATION SO ARCHIVES OF INTERNAL MEDICINE LA English DT Article ID PERSIAN-GULF-WAR; PYRIDOSTIGMINE; SYMPTOMS; SUPPORT; DISEASE AB Between August 1990 and March 1991, the United States deployed 697 000 troops to the Persian Gulf to liberate Kuwait from Iraqi occupation. Since the Gulf War, most veterans seeking medical care at Departments of Veterans Affairs and Defense medical facilities have had diagnosable conditions, but the symptoms of several thousand veterans have not been readily explained. The most commonly reported, unexplained complaints have been chronic fatigue, rash, headache, arthralgias/myalgias, difficulty concentrating, forgetfulness, and irritability. These symptoms have not been localized to any one organ system, and there has been no consistent physical sign or laboratory abnormality that indicates a single specific disease. Because of the unexplained illnesses being experienced by some Gulf War troops, a comprehensive clinical and research effort has been organized by the Departments of Veterans Affairs, Defense, and Health and Human Services to provide care for veterans and to evaluate their medical problems. To determine the causes and most effective treatments of illnesses among Gulf War veterans, a thorough understanding of all potential health risks associated with service in the Persian Gulf is necessary. These risks are reviewed in this article and include possible reactions to prophylactic drugs and vaccines, infectious diseases, and exposures to chemicals, radiation, and smoke from oil fires. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. USA,ENVIRONM MED RES INST,NATICK,MA. DEPT VET AFFAIRS,WASHINGTON,DC. VET AFFAIRS MED CTR,BIRMINGHAM,AL. CTR DIS CONTROL & PREVENT,ATLANTA,GA 30341. RP RONALD, MG (reprint author), PERSIAN GULF VET COORDINATING BOARD,TECHNOL WORLD,S BLDG,SUITE 450,800 K ST NW,WASHINGTON,DC 20575, USA. NR 33 TC 123 Z9 123 U1 0 U2 5 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern Med. PD FEB 13 PY 1995 VL 155 IS 3 BP 262 EP 268 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA QF095 UT WOS:A1995QF09500003 ER PT J AU OEHRLE, SA BOSSLE, PC AF OEHRLE, SA BOSSLE, PC TI ANALYSIS OF NERVE AGENT DEGRADATION PRODUCTS USING CAPILLARY ION ELECTROPHORESIS SO JOURNAL OF CHROMATOGRAPHY A LA English DT Note CT 18th International Symposium on Column Liquid Chromatography CY MAY 08-13, 1994 CL MINNEAPOLIS, MN ID ANIONS; OPTIMIZATION; WATER AB A method has been developed for the analysis of nerve agent degradation products using capillary ion electrophoresis. Analysis of the primary degradation products isopropyl methylphosphonic acid, ethyl methylphosphonic acid, pinacolyl methylphosphonic acid and methylphosphonic acid was accomplished with run times of less than 5 min. Detection of low mg/l levels of degradation products in spiked water samples was possible. Little sample preparation was required for the analysis of the alkyl methylphosphonic acids. C1 USA,EDGEWOOD RES,CTR DEV & ENGN,RES & TECHNOL DIRECTORATE,ABERDEEN PROVING GROUND,MD 21010. RP OEHRLE, SA (reprint author), WATERS CORP,34 MAPLE ST,MILFORD,MA 01757, USA. NR 9 TC 44 Z9 44 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0021-9673 J9 J CHROMATOGR A JI J. Chromatogr. A PD FEB 10 PY 1995 VL 692 IS 1-2 BP 247 EP 252 DI 10.1016/0021-9673(94)01024-9 PG 6 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA QJ001 UT WOS:A1995QJ00100030 ER PT J AU BASSETT, GM WOODWARD, PR AF BASSETT, GM WOODWARD, PR TI NUMERICAL-SIMULATION OF NONLINEAR KINK INSTABILITIES ON SUPERSONIC SHEAR LAYERS SO JOURNAL OF FLUID MECHANICS LA English DT Article ID VORTEX SHEETS; MODES AB Nonlinear kink instabilities of high-Reynolds-number supersonic shear layers have been studied using high-resolution computer simulations with the piecewise-parabolic-method (PPM). The transition region between the two fluids of the shear layer is spread out over many computational zones to avoid numerical effects introduced on the smallest lengthscales. Mach number, density contrast, and perturbation speed and amplitude were varied to study their effects on the growth of the kink instabilities. In response to a perturbing sound wave, a travelling kink mode grows in amplitude until enough of a disturbance on the shear layer has been created for it to roll up and rapidly grow in thickness. The time it takes for this rapid growth to be initiated is proportional to the initial shear-layer thickness and increases for increasing Mach number or decreasing perturbation amplitude. For equal density, Mach 4 shear layers, perturbed by a sound wave with a 2% amplitude at the traveling mode velocity, the growth time is T-g = (546 +/- 24) delta/c, where c is the sound speed and delta the half-width of the shear layer. C1 UNIV MINNESOTA, MINNESOTA SUPERCOMP INST, MINNEAPOLIS, MN 55455 USA. RP BASSETT, GM (reprint author), UNIV MINNESOTA, ARMY HIGH PERFORMANCE COMP RES CTR, DEPT ASTRON, MINNEAPOLIS, MN 55455 USA. NR 15 TC 6 Z9 6 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0022-1120 EI 1469-7645 J9 J FLUID MECH JI J. Fluid Mech. PD FEB 10 PY 1995 VL 284 BP 323 EP 340 DI 10.1017/S0022112095000371 PG 18 WC Mechanics; Physics, Fluids & Plasmas SC Mechanics; Physics GA QK089 UT WOS:A1995QK08900014 ER PT J AU HAMEKA, HF JENSEN, JO AF HAMEKA, HF JENSEN, JO TI CALCULATIONS OF THE ENERGIES, GEOMETRIES AND VIBRATIONAL FREQUENCIES OF THE GROUND AND FIRST EXCITED SINGLET-STATES OF TOLUENE AND P-CRESOL SO THEOCHEM-JOURNAL OF MOLECULAR STRUCTURE LA English DT Article ID ELECTRON-DIFFRACTION; INFRARED FREQUENCIES; MOLECULAR-STRUCTURE AB We attempt to interpret the fluorescence of toluene and p-cresol from ab initio calculations on the ground state and the lowest excited singlet state of each molecule. We determine the energy minima and the optimized geometries of the ground states and of the lowest excited singlet states from 4 in 4 CASSCF computations using a 6-31G basis set. We also compute the vibrational frequencies of both molecules in the two states. C1 USA,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP HAMEKA, HF (reprint author), UNIV PENN,DEPT CHEM,PHILADELPHIA,PA 19104, USA. NR 22 TC 34 Z9 34 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 THEOCHEM-J MOL STRUC JI Theochem-J. Mol. Struct. PD FEB 10 PY 1995 VL 331 IS 3 BP 203 EP 214 DI 10.1016/0166-1280(94)03888-R PG 12 WC Chemistry, Physical SC Chemistry GA QQ619 UT WOS:A1995QQ61900001 ER PT J AU DECOSTER, MA KLETTE, KL KNIGHT, ES TORTELLA, FC AF DECOSTER, MA KLETTE, KL KNIGHT, ES TORTELLA, FC TI SIGMA-RECEPTOR-MEDIATED NEUROPROTECTION AGAINST GLUTAMATE TOXICITY IN PRIMARY RAT NEURONAL CULTURES SO BRAIN RESEARCH LA English DT Article DE GLUTAMATE TOXICITY; LACTATE DEHYDROGENASE; NEURONAL CULTURE; SIGMA-MEDIATED NEUROPROTECTION; INTRACELLULAR CALCIUM; NEURONAL MORPHOLOGY ID D-ASPARTATE RECEPTOR; GLOBAL BRAIN ISCHEMIA; DORSAL HIPPOCAMPUS; LIGANDS; NEUROTOXICITY; BINDING; INVIVO; DEXTROMETHORPHAN; ANTAGONISTS; SKF-10,047 AB The role of the putative a receptor in mediating neuroprotection against glutamate-induced neuronal injury was examined in mature cultured rat cortical neurons. With the exception of the selective sigma(1) ligand (+)-3-PPP, all of the sigma ligands tested were neuroprotective, preventing glutamate-induced morphological changes and increases in LDH release. Their rank order of neuroprotective potency (and EC(50) values) was as follows: (+)-SKF 10,047 (0.81 mu M)>(+)-cyclazocine (2.3 mu M)>dextromethorphan (3.1 mu M) = haloperidol (3.7 mu M)>(+)-pentazocine (8.5 mu M)>DTG (42.7 mu M) = carbetapentane (46.3 mu M). When corrected for relative sigma versus PCP binding affinity, it appears that a positive correlation exists between neuroprotective potency and sigma(1) site affinity. However, there does not appear to be a significant correlation between neuroprotective potency and the sigma(2) site. Critically, none of the a ligands were neurotoxic when tested alone at concentrations at least 5-30 times their respective neuroprotective EC(50) values. Results from preliminary experiments with the selective sigma(1) ligand (+)-pentazocine indicated that sigma-mediated neuroprotection may involve the buffering of glutamate-induced calcium flux. Collectively, the results of these in vitro experiments demonstrate that sigma ligands are neuroprotective and therefore deserve further exploration as potential therapeutic agents in in vivo models of CNS injury and neurodegenerative disorders. C1 WALTER REED ARMY INST RES,DEPT MED NEUROSCI,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,DIV FORENS TOXICOL,OFF ARMED FORCES MED EXAMINER,WASHINGTON,DC 20306. NR 26 TC 93 Z9 93 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 J9 BRAIN RES JI Brain Res. PD FEB 6 PY 1995 VL 671 IS 1 BP 45 EP 53 DI 10.1016/0006-8993(94)01294-R PG 9 WC Neurosciences SC Neurosciences & Neurology GA QG261 UT WOS:A1995QG26100006 PM 7728532 ER PT J AU ALLEY, RB GOW, AJ JOHNSEN, SJ KIPFSTUHL, J MEESE, DA THORSTEINSSON, T AF ALLEY, RB GOW, AJ JOHNSEN, SJ KIPFSTUHL, J MEESE, DA THORSTEINSSON, T TI COMPARISON OF DEEP ICE CORES SO NATURE LA English DT Letter ID GISP2 C1 ALFRED WEGENER INST POLAR & MARINE RES,D-27568 BREMERHAVEN,GERMANY. PENN STATE UNIV,CTR EARTH SYST SCI,UNIVERSITY PK,PA 16802. PENN STATE UNIV,DEPT GEOSCI,UNIVERSITY PK,PA 16802. USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. UNIV COPENHAGEN,NIELS BOHR INST,DK-2200 COPENHAGEN,DENMARK. NR 6 TC 97 Z9 99 U1 0 U2 6 PU MACMILLAN MAGAZINES LTD PI LONDON PA 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF SN 0028-0836 J9 NATURE JI Nature PD FEB 2 PY 1995 VL 373 IS 6513 BP 393 EP 394 DI 10.1038/373393b0 PG 2 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA QE670 UT WOS:A1995QE67000040 ER PT J AU MATOCHIK, JA MOLCHAN, SE ZAMETKIN, AJ WARDEN, DL SUNDERLAND, T COHEN, RM AF MATOCHIK, JA MOLCHAN, SE ZAMETKIN, AJ WARDEN, DL SUNDERLAND, T COHEN, RM TI REGIONAL CEREBRAL GLUCOSE-METABOLISM IN AUTOPSY-CONFIRMED CREUTZFELDT-JAKOB-DISEASE SO ACTA NEUROLOGICA SCANDINAVICA LA English DT Note DE CREUTZFELDT-JAKOB DISEASE; POSITRON EMISSION TOMOGRAPHY; GLUCOSE METABOLISM; PRION DISEASE; ENCEPHALOPATHY; DEMENTIA ID POSITRON EMISSION TOMOGRAPHY AB Regional cerebral glucose metabolism was measured in a 72-year-old man, with Creutzfeldt-Jakob disease (CJD), by positron emission tomography using [F-18]-2-fluoro-2-deoxy-D-glucose as the tracer. The diagnosis of CJD, a rare neurodegenerative disorder, was confirmed at autopsy 13 months later. Compared with five unaffected elderly men, the patient had reduced metabolism heterogeneously distributed throughout the brain. The hypometabolism was most evident in the right hemisphere, particularly in the posterior frontal, parietal, Sylvian, and temporal regions. This left-right asymmetry is more extensive than that previously reported in Alzheimer's disease, and may provide a useful metabolic marker for early diagnosis of CJD. C1 NIMH,CLIN SCI LAB,GERIATR PSYCHIAT SECT,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP MATOCHIK, JA (reprint author), NIMH,CEREBRAL METAB LAB,CLIN BRAIN IMAGING SECT,BLDG 10,ROOM 4N317,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA. NR 13 TC 10 Z9 10 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0001-6314 J9 ACTA NEUROL SCAND JI Acta Neurol. Scand. PD FEB PY 1995 VL 91 IS 2 BP 153 EP 157 PG 5 WC Clinical Neurology SC Neurosciences & Neurology GA QR036 UT WOS:A1995QR03600013 PM 7785428 ER PT J AU YU, YH LEE, S MCALISTER, KW TUNG, C WANG, CM AF YU, YH LEE, S MCALISTER, KW TUNG, C WANG, CM TI DYNAMIC STALL CONTROL FOR ADVANCED ROTORCRAFT APPLICATION SO AIAA JOURNAL LA English DT Article AB Advanced concepts designed to improve the lift, drag, and pitching moment characteristics of rotor blades have been investigated for the purpose of enhancing rotor maneuver capability. The advantages and disadvantages of these concepts have been evaluated using both computational and experimental means. The concepts that mere considered in this study included a leading-edge slat, a deformable leading-edge, and upper-surface blowing. The results show the potential of these concepts for substantially improving the performance of a rotor. C1 GEORGIA INST TECHNOL,SCH AEROSP ENGN,ATLANTA,GA 30332. USA,AEROFLIGHTDYNAM DIRECTORATE,STERLING FED SYST,MOFFETT FIELD,CA 94035. NR 12 TC 28 Z9 28 U1 0 U2 2 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0001-1452 J9 AIAA J JI AIAA J. PD FEB PY 1995 VL 33 IS 2 BP 289 EP 295 DI 10.2514/3.12496 PG 7 WC Engineering, Aerospace SC Engineering GA QK492 UT WOS:A1995QK49200014 ER PT J AU RAINES, EF AF RAINES, EF TI IN MANY A STRIFE - THOMAS,GERALD,C. AND THE UNITED-STATES-MARINE-CORPS, 1917-1956 - MILLETT,AR SO AMERICAN HISTORICAL REVIEW LA English DT Book Review RP RAINES, EF (reprint author), USA,CTR MIL HIST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER HISTORICAL REVIEW PI WASHINGTON PA 400 A ST SE, WASHINGTON, DC 20003 SN 0002-8762 J9 AM HIST REV JI Am. Hist. Rev. PD FEB PY 1995 VL 100 IS 1 BP 263 EP 263 DI 10.2307/2168171 PG 1 WC History SC History GA QH807 UT WOS:A1995QH80700191 ER PT J AU BEIDLEMAN, BA PUHL, JL DESOUZA, MJ AF BEIDLEMAN, BA PUHL, JL DESOUZA, MJ TI ENERGY-BALANCE IN FEMALE DISTANCE RUNNERS SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article DE ENERGY INTAKE; ENERGY EXPENDITURE; ENERGY BALANCE; RESTING METABOLIC RATE; THERMAL EFFECT OF A TEST MEAL; THERMAL EFFECT OF ACTIVITY; HEART RATE MONITORING ID RESTING METABOLIC-RATE; DOUBLY-LABELED WATER; HEART-RATE; AEROBIC FITNESS; EXPENDITURE; WOMEN; THERMOGENESIS; CALORIMETRY; MASS; DIET AB Metabolic efficiency was assessed in ovulatory eumenorrheic female distance runners and untrained control subjects of similar age, body weight, and fat-free mass (FFM). Energy intake (EI) was estimated from 3-d dietary records. Energy expenditure (EE) was determined during the same 3-d period from individual heartrate oxygen uptake (HR/VO2) curves during rest and exercise, 24-h HR records, and the thermic effect of meals. The runners and control subjects did not differ in resting metabolic rate statistically adjusted for FFM (kJ/min), the thermic effect of a test meal (kJ/3 h) the energy cost of submaximal physical activity, or EI. EE was higher (P = 0.01) in the runners. Reported EI was lower than EE in both the runners (P = 0.007) and control subjects, (P = 0.006), resulting in energy deficits of -4131 +/- 1185 kJ/d and -1652 +/- 456 kJ/d, respectively. These female runners did not exhibit an enhanced metabolic efficiency compared with the control subjects. It is possible that the energy deficit for both the runners and control subjects was due to both restricted eating and underreporting during the measurement period. Additional studies using longer measurement periods, more sophisticated technology (ie, doubly labeled water, more subjects, and subjects of varying menstrual and energy intake status) are needed to truly answer this question. C1 SPRINGFIELD COLL,DEPT PHYS EDUC,SPRINGFIELD,MA. RHODE ISL HOSP,DIV GEN INTERNAL MED,PROVIDENCE,RI 02903. BROWN UNIV,PROVIDENCE,RI. UNIV CONNECTICUT,CTR HLTH,DEPT OBSTET & GYNECOL,FARMINGTON,CT. RP BEIDLEMAN, BA (reprint author), USA,ENVIRONM MED RES INST,DIV ALTITUDE PHYSIOL & MED,NATICK,MA 01760, USA. NR 40 TC 24 Z9 24 U1 1 U2 1 PU AMER SOC CLIN NUTRITION INC PI BETHESDA PA 9650 ROCKVILLE PIKE SUBSCRIPTIONS, RM L-2310, BETHESDA, MD 20814-3998 SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD FEB PY 1995 VL 61 IS 2 BP 303 EP 311 PG 9 WC Nutrition & Dietetics SC Nutrition & Dietetics GA QD951 UT WOS:A1995QD95100009 PM 7840067 ER PT J AU KRYWICKI, R BOWEN, K ANDERSON, L GARLAND, D COBB, P JENKINS, T OROURKE, T AF KRYWICKI, R BOWEN, K ANDERSON, L GARLAND, D COBB, P JENKINS, T OROURKE, T TI MIXED-LINEAGE ACUTE MYELOID-LEUKEMIA ASSOCIATED WITH A SUPRASELLAR SYSGERMINOMA SO AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS LA English DT Article DE DYSGERMINOMA; ACUTE MYELOID LEUKEMIA ID GERM-CELL TUMORS; HEMATOLOGIC MALIGNANCIES; TERATOMA; CHEMOTHERAPY; ORIGIN AB An association between primary mediastinal germ cell tumors and hematologic malignancies has been recognized since 1985. We present a patient with a suprasellar germ cell tumor and an associated leukemia. A 20-year-old black female presented in December 1987 with a 6-month history of headaches and weight loss, confusion, polyuria, and polydipsia. Evaluation revealed hypernatremia, normal neurologic examination except poor recall, and an enhancing inhomogeneous suprasellar mass on cranial computed tomography. Biopsy of the mass diagnosed a dysgerminoma, which was treated with craniospinal radiation. In February 1988, the patient developed pancytopenia, which resolved with discontinuation of cimetidine and phenytoin. She did well until June 1988 when she presented with skin lesions over the trunk and extremities. Skin biopsy revealed a leukemic infiltration. She was admitted with a WBC 1,500/mul (without blasts), Hb 11.6 g/dl, PLT 210,000 mul. Bone marrow biopsy revealed hypercellularity with 50% blasts, demonstrating mixed-lineage acute myeloblastic leukemia (myelomonocytic-M4; megakaryoblastic-M7). The patient was induced with a standard Ara-C/daunorubicin regimen. Two weeks postinduction, she became septic and expired. An autopsy demonstrated leukemic involvement of the spleen, liver, bone marrow, and skin, without residual dysgerminoma. This represents the first reported case of suprasellar dysgerminoma associated with a mixed-lineage leukemia not related to chemotherapy. C1 BROOKE ARMY MED CTR,HEMATOL ONCOL SERV,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DEPT MED,DERMATOL SERV,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DEPT PATHOL,FT SAM HOUSTON,TX 78234. NR 22 TC 6 Z9 6 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0277-3732 J9 AM J CLIN ONCOL-CANC JI Am. J. Clin. Oncol.-Cancer Clin. Trials PD FEB PY 1995 VL 18 IS 1 BP 83 EP 86 DI 10.1097/00000421-199502000-00018 PG 4 WC Oncology SC Oncology GA QD531 UT WOS:A1995QD53100018 PM 7847266 ER PT J AU REGENNITTER, FJ VOLZ, JE AF REGENNITTER, FJ VOLZ, JE TI AN INTRODUCTION TO THE INTERNET SO AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS LA English DT Article RP REGENNITTER, FJ (reprint author), USA,DENT CORPS,FT KNOX,KY 40121, USA. NR 0 TC 7 Z9 7 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0889-5406 J9 AM J ORTHOD DENTOFAC JI Am. J. Orthod. Dentofac. Orthop. PD FEB PY 1995 VL 107 IS 2 BP 214 EP 217 DI 10.1016/S0889-5406(95)70135-4 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA QG769 UT WOS:A1995QG76900015 PM 7847278 ER PT J AU ECHEVERRIA, P HOGE, CW BODHIDATTA, L SERICHANTALERGS, O DALSGAARD, A EAMPOKALAP, B PERRAULT, J PAZZAGLIA, G OHANLEY, P ENGLISH, C AF ECHEVERRIA, P HOGE, CW BODHIDATTA, L SERICHANTALERGS, O DALSGAARD, A EAMPOKALAP, B PERRAULT, J PAZZAGLIA, G OHANLEY, P ENGLISH, C TI MOLECULAR CHARACTERIZATION OF VIBRIO-CHOLERAE O139 ISOLATES FROM ASIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID TOXIN GENES; THAILAND AB In 1992, a serologically novel clone of Vibrio cholerae, designated O139, caused large epidemics of diarrhea in India and Bangladesh. To determine the extent of the spread of V. cholerae O139 worldwide, 484 V. cholerae non-O1 strains isolated from different patients with diarrhea in Thailand, Indonesia, the Philippines, and Peru in 1993 were tested for agglutination in O139 antisera. One hundred fifty-one of these 484 isolates were examined for genes encoding cholera toxin, zonula occlulans toxin, the repetitive sequence 1, and the toxin coregulated pilin A (the V. cholerae virulence gene complex). Thirty-three percent (122 of 364) of V. cholerae non-O1 strains isolated from different patients with diarrhea in Thailand agglutinated in O139 antisera. Ninety-eight percent (120 of 122) of V. cholerae O139 contained the V. cholerae virulence gene complex. None of the 104 V. cholerae non-Ol strains isolated from patients with diarrhea in Indonesia or the 14 strains from patients with diarrhea in the Philippines were serotype O139. Four different ribotypes were found in V. cholerae O139 isolated in Asia. Twenty-three (47%) of 49 Thai O139 strains examined were of different ribotypes than isolates from India and Bangladesh; V. cholerae strains that were not O1 or O139 that were isolated from flies and water in Thailand 11 years previously in 1981 contained the same V. cholerae virulence gene complex found in V. cholerae O1 and O139. This suggests that other unidentified virulence determinants are involved in V. cholerae O139 pathogenesis. C1 ARMED FORCES RES INST MED SCI,BANGKOK 10400,THAILAND. ROYAL VET & AGR UNIV,FREDERIKSBERG,DENMARK. BAMRASNARADURA INFECT DIS HOSP,NONTHABURI,THAILAND. NAVAL MED RES UNIT DETACHMENT 2,MANILA,PHILIPPINES. NAVAL MED RES UNIT 2,JAKARTA,INDONESIA. NAVAL MED RES INST DETACHMENT,LIMA,PERU. NR 18 TC 14 Z9 14 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 1995 VL 52 IS 2 BP 124 EP 127 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA QL877 UT WOS:A1995QL87700002 PM 7872438 ER PT J AU ANDERSEN, SL AGER, A MCGREEVY, P SCHUSTER, BG WESCHE, D KUSCHNER, R OHRT, C ELLIS, W ROSSAN, R BERMAN, J AF ANDERSEN, SL AGER, A MCGREEVY, P SCHUSTER, BG WESCHE, D KUSCHNER, R OHRT, C ELLIS, W ROSSAN, R BERMAN, J TI ACTIVITY OF AZITHROMYCIN AS A BLOOD SCHIZONTICIDE AGAINST RODENT AND HUMAN PLASMODIA IN-VIVO SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID CHLOROQUINE-RESISTANT; FALCIPARUM-MALARIA; ERYTHROMYCIN; TETRACYCLINE; QUININE AB We compared the efficacy of azithromycin to the clinical antimalarial doxycycline in Plasmodium berghei-infected mice and in P. falciparum-infected Aotus monkeys. When mice were administered drug orally twice a day for three days, the minimum total dose of azithromycin that cured all mice was 768 mg/kg. Doxycycline at a dose of 1,536 mg/kg cured no mice. The efficacy of fast-acting blood schizonticides (quinine, halofantrine, artemisinin) against P, berghei was augmented by azithromycin. In monkey experiments in which there were two animals per experimental group, azithromycin (100 mg/kg/day for seven days) eliminated parasitemia; azithromycin (30 mg/ kg/day) initially cleared 99.8-100% of the parasites with recrudescence in the one completely cleared case. Doxycycline (30 mg/kg/day) cleared 100% of the parasites with recrudescence in both cleared cases. Since azithromycin can be clinically administered at a somewhat higher daily dosage than doxycycline, the data suggest that it may be possible to replace drugs of the tetracycline class with azithromycin in combination with fast-acting blood schizonticides for the treatment of P. falciparum infection. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. CTR TROP DIS,DEPT MICROBIOL & IMMUNOL,MIAMI,FL 33177. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. GORGAS MEM LAB,PANAMA CITY,PANAMA. NR 9 TC 39 Z9 40 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 1995 VL 52 IS 2 BP 159 EP 161 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA QL877 UT WOS:A1995QL87700009 PM 7872444 ER PT J AU TURELL, MJ KORCH, GW ROSSI, CA SESLINE, D ENGE, BA DONDERO, DV JAY, M LUDWIG, GV LI, D SCHMALJOHN, CS JACKSON, RJ ASCHER, MS AF TURELL, MJ KORCH, GW ROSSI, CA SESLINE, D ENGE, BA DONDERO, DV JAY, M LUDWIG, GV LI, D SCHMALJOHN, CS JACKSON, RJ ASCHER, MS TI PREVALENCE OF HANTAVIRUS INFECTION IN RODENTS ASSOCIATED WITH 2 FATAL HUMAN INFECTIONS IN CALIFORNIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Note AB Rodents living near two fatal human cases of hantavirus pulmonary syndrome in California were surveyed for evidence of hantavirus infection. Seventeen (15%) (14 Peromyscus maniculatus and one each of P. truei, Eutamias minimus, and Microtus californicus) of 114 rodents tested had evidence (enzyme-linked immunosorbent assay or polymerase chain reaction) of hantavirus infection. This suggests that Peromyscus mice, and P. maniculatus in particular, may be the reservoir for the virus causing this newly recognized disease in California, as previously reported for New Mexico and Arizona. C1 CALIF DEPT HLTH SERV,BERKELEY,CA 94704. RP TURELL, MJ (reprint author), USA,MED RES INST INFECT DIS,FT DETRICK,FREDERICK,MD 21702, USA. NR 8 TC 7 Z9 7 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 1995 VL 52 IS 2 BP 180 EP 182 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA QL877 UT WOS:A1995QL87700015 PM 7872450 ER PT J AU SHARP, TW THORNTON, SA WALLACE, MR DEFRAITES, RE SANCHEZ, JL BATCHELOR, RA ROZMAJZL, PJ HANSON, RK ECHEVERRIA, P KAPIKIAN, AZ XIANG, XJ ESTES, MK BURANS, JP AF SHARP, TW THORNTON, SA WALLACE, MR DEFRAITES, RE SANCHEZ, JL BATCHELOR, RA ROZMAJZL, PJ HANSON, RK ECHEVERRIA, P KAPIKIAN, AZ XIANG, XJ ESTES, MK BURANS, JP TI DIARRHEAL-DISEASE AMONG MILITARY-PERSONNEL DURING OPERATION-RESTORE-HOPE, SOMALIA, 1992-1993 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID HOUSEFLIES MUSCA-DOMESTICA; TRAVELERS DIARRHEA; DESERT-SHIELD; SHIGELLOSIS; TRANSMISSION; PATHOGENS; STORM; TRIAL AB The potential for widespread diarrheal disease was regarded as a substantial threat to U.S. troops participating in the early phases of Operation Restore Hope in Somalia. Outpatient surveillance of 20,859 U.S. troops deployed during the first eight weeks, however, indicated that a mean of only 0.8% (range 0.5-1.2%) of personnel sought care for diarrhea each week, and in three epidemiologic surveys, < 3% of troops reported experiencing a diarrheal illness per week. Despite these low overall attack rates, diarrhea accounted for 16% of 381 hospital admissions and 20% of 245 patients admitted with a temperature greater than or equal to 38.5 degrees C. Sixty-one specimens were obtained from inpatients and 52 were obtained from outpatients. Shigella sp. were isolated from 33%, enterotoxigenic Escherichia coli from 16%, Giardia lamblia from 4%, and rotavirus from 1% of 113 stool samples obtained from inpatient (61) and outpatient (52) troops with diarrhea. Bacterial isolates obtained in Somalia were resistant to doxycycline (78%), ampicillin (54%), and sulfamethoxazole (49%), but uniformly sensitive to ciprofloxacin. With the exception of 10 Shigella sonnei isolates that were linked epidemiologically to one eating facility, bacterial pathogens occurred sporadically and demonstrated a wide variation of serotypes and antibiotic sensitivity patterns. Additionally, three of 11 paired sera collected from persons with nausea, vomiting, and watery diarrhea demonstrated a four-fold or greater increase in titer to Norwalk virus antibody. These data indicate that large outbreaks of diarrheal disease did not occur; however, highly drug-resistant enteric bacteria, and to a lesser extent viral and parasitic pathogens, were important causes of morbidity among U.S. troops in Somalia. C1 USN,MED RES INST,BETHESDA,MD 20889. USN,MED CTR,DIV INFECT DIS,SAN DIEGO,CA 92134. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV PREVENT MED,WASHINGTON,DC 20307. USN,ENVIRONM & PREVENT MED UNIT 7,NAPLES,ITALY. USN,MED RES UNIT 3,CAIRO,EGYPT. USN,ENVIRONM & PREVENT MED UNIT 6,HONOLULU,HI. ARMED FORCES RES INST MED SCI,BANGKOK 10400,THAILAND. NIAID,INFECT DIS LAB,BETHESDA,MD 20892. BAYLOR COLL MED,TEXAS MED CTR,DIV MOLEC VIROL,HOUSTON,TX 77030. NR 32 TC 51 Z9 51 U1 1 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 1995 VL 52 IS 2 BP 188 EP 193 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA QL877 UT WOS:A1995QL87700017 PM 7872452 ER PT J AU ROSENBERG, M SCHOOLER, C SCHOENBACH, C ROSENBERG, F AF ROSENBERG, M SCHOOLER, C SCHOENBACH, C ROSENBERG, F TI GLOBAL SELF-ESTEEM AND SPECIFIC SELF-ESTEEM - DIFFERENT CONCEPTS, DIFFERENT OUTCOMES SO AMERICAN SOCIOLOGICAL REVIEW LA English DT Article ID SOCIAL-CLASS AB In this paper, we attempt to shed light on the nature of relevance of, and relationship between global self-esteem and specific self-esteem. We marshal evidence that the two types of self-esteem may have strikingly different consequences, global self-esteem being more relevant to psychological wellbeing, and specific self-esteem being more relevant to behavior. We use linear structural equation causal modeling to test this hypothesis for the case of global self-esteem (Rosenberg 1979) and specific (academic) self-esteem. Our findings show that, while global self-esteem is more strongly related to measures of psychological well-being, specific (academic) self-esteem is a much better predictor of school performance. Other findings indicate that the degree to which specific academic self-esteem affects global self-esteem, particularly the positive component of global self-esteem, is a function of how highly academic performance is personally valued. C1 NIMH,SOCIOENVIRONM STUDIES LAB,BETHESDA,MD 20892. UNIV MARYLAND,COLLEGE PK,MD 20742. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT PSYCHIAT,BETHESDA,MD 20814. NR 61 TC 409 Z9 423 U1 14 U2 137 PU AMER SOCIOLOGICAL ASSOC PI WASHINGTON PA 1722 N ST NW, WASHINGTON, DC 20036-2981 SN 0003-1224 J9 AM SOCIOL REV JI Am. Sociol. Rev. PD FEB PY 1995 VL 60 IS 1 BP 141 EP 156 DI 10.2307/2096350 PG 16 WC Sociology SC Sociology GA RC478 UT WOS:A1995RC47800009 ER PT J AU FONTANA, JL WELBORN, L MONGAN, PD STURM, P MARTIN, G BUNGER, R AF FONTANA, JL WELBORN, L MONGAN, PD STURM, P MARTIN, G BUNGER, R TI OXYGEN-CONSUMPTION AND CARDIOVASCULAR FUNCTION IN CHILDREN DURING PROFOUND INTRAOPERATIVE NORMOVOLEMIC HEMODILUTION SO ANESTHESIA AND ANALGESIA LA English DT Article ID CRITICAL-LEVEL; DELIVERY; ERYTHROCYTES; ANESTHESIA AB The clinically acceptable limit of acute normovolemic, normothermic hemodilution, a standard procedure in scoliosis surgery, is not yet well defined. Eight ASA class I patients undergoing idiopathic scoliosis correction were administered a standard anesthetic with 100% oxygen and controlled ventilation. Hemodilution was accomplished by exchanging whole blood for 5% albumin in 0.9% saline. Blood gases, acid-base status, and circulatory variables were recorded prior to and after hemodilution, and every 30 min throughout surgery. The impact of hemodilution was judged by mixed venous oxygen saturation which was maintained at greater than or equal to 60%, while intravascular volume was maintained with the 5% albumin solution. Reinfusion of the autologous blood was completed by the end of surgery. In the eight controlled cases in which normovolemic hemodilution was studied, hemoglobin levels decreased from 10.0 +/- 1.6 g/dL to 3.0 +/- 0.8 g/dL. Mixed venous oxygen saturation decreased from 90.8% +/- 5.4% to 72.3% +/- 7.8%. Oxygen extraction ratio increased from 17.3% +/- 6.2% to 44.4% +/- 5.9%. Oxygen delivery decreased from 532.1 +/- 138.1 mL.min(-1).m(-2) to 260.2 +/- 57.1 mL.min(-1).m(-2), while global oxygen consumption did not decrease and plasma lactate did not appreciably increase. Central venous pressure increased and peripheral resistance decreased during hemodilution. Cardiac index increased, heart rate remained essentially constant, and left ventricular stroke work index did not decrease significantly. No patients suffered clinically ad verse outcomes. Global oxygen transport and myocardial work can be maintained at extreme normovolemic anemia. Our evidence suggests that stages of normovolemic hemodilution more severe than previously reported map be clinically acceptable for young, healthy patients during normocarbic anesthesia. C1 CHILDRENS NATL MED CTR,WASHINGTON,DC. WALTER REED ARMY MED CTR,WASHINGTON,DC. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX. RP FONTANA, JL (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT ANESTHESIOL,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 26 TC 118 Z9 123 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD FEB PY 1995 VL 80 IS 2 BP 219 EP 225 DI 10.1097/00000539-199502000-00003 PG 7 WC Anesthesiology SC Anesthesiology GA QD734 UT WOS:A1995QD73400003 PM 7818103 ER PT J AU MARTINEZ, MJ KONZELMAN, JL ENGLER, RJM AF MARTINEZ, MJ KONZELMAN, JL ENGLER, RJM TI PERSISTENT WHITE LESIONS OF THE TONGUE IN A PATIENT WITH LOW CD4 COUNTS SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY LA English DT Discussion ID ORAL HAIRY LEUKOPLAKIA; HIV-INFECTION; TRANSPLANT PATIENT; T-LYMPHOCYTOPENIA; VIRUS; MANAGEMENT; RISK; IMMUNODEFICIENCY; LEUCOPLAKIA; DEFICIENCY C1 WALTER REED ARMY MED CTR,JACKSON FDN MED EDUC & RES,WASHINGTON,DC 20307. RP MARTINEZ, MJ (reprint author), WALTER REED ARMY MED CTR,ALLERGY IMMUNOL SERV,WASHINGTON,DC 20307, USA. NR 31 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL ALLERGY ASTHMA IMMUNOLOGY PI ARLINGTON HTS PA 85 WEST ALGONQUIN RD SUITE 550, ARLINGTON HTS, IL 60005 SN 1081-1206 J9 ANN ALLERG ASTHMA IM JI Ann. Allergy Asthma Immunol. PD FEB PY 1995 VL 74 IS 2 BP 134 EP 139 PG 6 WC Allergy; Immunology SC Allergy; Immunology GA QK907 UT WOS:A1995QK90700003 PM 7697471 ER PT J AU ENGLER, RJM SQUIRE, E BENSON, P AF ENGLER, RJM SQUIRE, E BENSON, P TI CHRONIC SULFASALAZINE THERAPY IN THE TREATMENT OF DELAYED PRESSURE URTICARIA AND ANGIOEDEMA SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY LA English DT Article ID CETIRIZINE; SULPHASALAZINE; DISEASE AB Background: Delayed pressure urticaria/angioedema can be profoundly disabling with painful and prolonged swelling of feet and hands as well as systemic symptoms of malaise and flu-like illness. Occupations requiring prolonged standing and forceful use of hands may be seriously compromised by this condition. The severe forms of the disease are usually unresponsive to antihistamines and nonsteroidal anti-inflammatory drugs, and patients frequently require corticosteroids for control of symptoms. Objective: It was the purpose of this report to evaluate the clinical utility of sulfasalazine for two patients with refractory delayed pressure urticaria. Methods: Sulfasalazine, starting at 500 mg/day (with weekly incremental dosing to a total of 4 g), was administered to two patients with disabling pressure urticaria and angioedema (symptomatic daily with normal activities) who had failed all other reported therapeutic options except corticosteroids. Results: Patient A required daily prednisone in excess of 30 mg (for more than 6 months) to control his painful angioedema sufficiently in order to continue working asa colorectal surgeon. Patient B also experienced daily symptoms for more than 1 year. Both patients tolerated sulfasalazine to a dose of 4 g/day without adverse reactions and achieved complete resolution of symptoms. Patient A continued to be well controlled 1 year after starting but must maintain a dose of 2 g or greater per day. Patient B reported excellent control 6 months after starting but was subsequently lost to follow-up. Conclusion: Sulfasalazine, in doses used for inflammatory bowel disease, appears to be an effective alternative therapy for delayed pressure urticaria and angioedema in patients poorly controlled by traditional treatment and may act as a corticosteroid-sparing agent. C1 WALTER REED ARMY MED CTR,SERV DERMATOL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,SCH MED,DEPT MED & PEDIAT,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,SCH MED,DEPT DERMATOL,BETHESDA,MD 20814. RP ENGLER, RJM (reprint author), WALTER REED ARMY MED CTR,ALLERGY IMMUNOL SERV,WASHINGTON,DC 20307, USA. NR 22 TC 46 Z9 46 U1 0 U2 0 PU AMER COLL ALLERGY ASTHMA IMMUNOLOGY PI ARLINGTON HTS PA 85 WEST ALGONQUIN RD SUITE 550, ARLINGTON HTS, IL 60005 SN 1081-1206 J9 ANN ALLERG ASTHMA IM JI Ann. Allergy Asthma Immunol. PD FEB PY 1995 VL 74 IS 2 BP 155 EP 159 PG 5 WC Allergy; Immunology SC Allergy; Immunology GA QK907 UT WOS:A1995QK90700007 PM 7697475 ER PT J AU ADEBONOJO, SA AF ADEBONOJO, SA TI HOW PROLONGED IS PROLONGED AIR LEAK SO ANNALS OF THORACIC SURGERY LA English DT Letter ID COMPLICATIONS RP ADEBONOJO, SA (reprint author), WALTER REED ARMY MED CTR,DEPT CARDIOTHORAC SURG,WASHINGTON,DC 20307, USA. NR 5 TC 9 Z9 9 U1 0 U2 0 PU ELSEVIER SCIENCE PUBL CO INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0003-4975 J9 ANN THORAC SURG JI Ann. Thorac. Surg. PD FEB PY 1995 VL 59 IS 2 BP 549 EP 549 PG 1 WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery SC Cardiovascular System & Cardiology; Respiratory System; Surgery GA QF299 UT WOS:A1995QF29900069 PM 7847995 ER PT J AU MARSHALL, DW BELL, R AF MARSHALL, DW BELL, R TI THE INFLUENCE OF SITUATION ON FOOD CHOICE SO APPETITE LA English DT Meeting Abstract C1 UNIV EDINBURGH,DEPT BUSINESS STUDIES,EDINBURGH EH8 9JV,MIDLOTHIAN,SCOTLAND. USA,NATICK RES DEV & ENGN CTR,DIV BEHAV SCI,NATICK,MA 01769. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ACADEMIC PRESS (LONDON) LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0195-6663 J9 APPETITE JI Appetite PD FEB PY 1995 VL 24 IS 1 BP 69 EP 69 PG 1 WC Behavioral Sciences; Nutrition & Dietetics SC Behavioral Sciences; Nutrition & Dietetics GA QH025 UT WOS:A1995QH02500024 ER PT J AU ZIMMERMAN, GC KEELING, JH BURRIS, HA COOK, G IRVIN, R KUHN, J MCCOLLOUGH, ML VONHOFF, DD AF ZIMMERMAN, GC KEELING, JH BURRIS, HA COOK, G IRVIN, R KUHN, J MCCOLLOUGH, ML VONHOFF, DD TI ACUTE CUTANEOUS REACTIONS TO DOCETAXEL, A NEW CHEMOTHERAPEUTIC AGENT SO ARCHIVES OF DERMATOLOGY LA English DT Article ID PLANTAR ERYTHRODYSESTHESIA SYNDROME; INDUCED ACRAL ERYTHEMA; TAXOTERE; RP-56976; ANALOG; TAXOL AB Background: Docetaxel (RP 56976) is a new chemotherapeutic agent that has shown promise in a number of animal studies and is currently undergoing phase I and phase II trials. Early in the phase I trials, it was noted that a significant number of patients were experiencing a variety of cutaneous complaints, so we elected to prospectively evaluate the cutaneous reactions occurring during the first three courses of therapy in the first 12 patients enrolled for phase I chemotherapy at our institutions. Observations: All but one patient had some type of cutaneous eruption over the three courses of therapy. Of the 27 evaluable courses of docetaxel given, 19 (70%) resulted in a cutaneous eruption with four (21%) being asymptomatic and 15 (79%) being at least mildly symptomatic. The most common reaction seen was characterized by discrete erythematous to violaceous patches or edematous plaques similar to acral erythema. Conclusion: Although a majority of patients receiving docetaxel experience some degree of cutaneous reaction, the eruptions are usually mildly symptomatic and almost always self-limiting. C1 BROOKE ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,FT SAM HOUSTON,TX. UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX. UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX. UNIV TEXAS,CANC THERAPY & RES CTR,SAN ANTONIO,TX. RP ZIMMERMAN, GC (reprint author), BROOKE ARMY MED CTR,DEPT MED,DERMATOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 15 TC 74 Z9 75 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD FEB PY 1995 VL 131 IS 2 BP 202 EP 206 DI 10.1001/archderm.131.2.202 PG 5 WC Dermatology SC Dermatology GA QG245 UT WOS:A1995QG24500013 PM 7857119 ER PT J AU GENTILE, BJ SZLYKMODROW, PC SILS, IV KRESTEL, BA TARTARINI, KA FRANCESCONI, RP AF GENTILE, BJ SZLYKMODROW, PC SILS, IV KRESTEL, BA TARTARINI, KA FRANCESCONI, RP TI SPLENIC EFFECTS ON HEMODYNAMICS INDUCED BY HYPOTHERMIA AND REWARMING IN MINIATURE SWINE SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID ACCIDENTAL HYPOTHERMIA; BLOOD-FLOW; PIGS AB Central arterial hemodynamic changes were assessed during cooling, hypothermia, and rewarming in splenectomized (SPX, n = 4) and unsplenectomized (SP, n = 4) 8-10 month old male Yucatan miniature swine (34.0 +/- 1.4 kg). Under isoflurane anesthesia, and using circulating-water blankets, pigs were cooled to and then maintained for 2 h at a rectal temperature (Tro) of 27 +/- 1 degrees C; hypothermia was followed by rewarming to normothermia (37 +/- 1 degrees C). There were significantly (p less than or equal to 0.05) greater changes in central arterial hematocrit and hemoglobin (Delta HCT and Delta HGB) from respective precooling baseline levels in the SP group during hypothermia and early rewarming (SP: Delta HCTmax = 9-10%RBC, and Delta HGBmax = 3.0-3.5 g/dl vs. SPX: Delta HCTmax = 3-4%RBC, and Delta HGBmax = 1.5-1.8 g/dl). By the end of rewarming, splenic resequestration and extravascular fluid shifts resulted in these values returning to baseline. In addition, cardiovascular instability was seen in the spy group compared to the SP animals as evidenced by significant tachycardia and hypotension during rewarming. We have concluded from these studies that hypothermia causes significant hemoconcentration, and that splenic contraction is the major cause of this hemoconcentration during hypothermia and initial rewarming in miniature swine. A splenectomized design should be considered for swine studies that purport to pattern human pathophysiology, especially for modelling rewarming shock. RP GENTILE, BJ (reprint author), USA,ENVIRONM MED RES INST,DIV COMPARAT PHYSIOL,NATICK,MA 01760, USA. NR 21 TC 3 Z9 3 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD FEB PY 1995 VL 66 IS 2 BP 143 EP 147 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA QE273 UT WOS:A1995QE27300009 PM 7726778 ER PT J AU YEE, E CHAN, R KOSTENIUK, PR CHANDLER, GM BILTOFT, CA BOWERS, JF AF YEE, E CHAN, R KOSTENIUK, PR CHANDLER, GM BILTOFT, CA BOWERS, JF TI MEASUREMENTS OF LEVEL-CROSSING STATISTICS OF CONCENTRATION FLUCTUATIONS IN PLUMES DISPERSING IN THE ATMOSPHERIC SURFACE-LAYER SO BOUNDARY-LAYER METEOROLOGY LA English DT Article ID TURBULENT BOUNDARY-LAYER; RECURRENCE AB The statistics of level crossings and local extremes in concentration fluctuations in plumes dispersing in the atmosphere have been investigated. A set of concentration fluctuation tracer experiments has been utilized to measure the statistical properties of the upcrossing interval (inter-arrival time between consecutive concentration bursts), excursion duration (persistence or width of concentration bursts), and concentration amplitude (difference between the maximum and minimum concentrations between successive upcrossings) with respect to a range of concentration crossing levels. In particular, the effect of downwind distance and atmospheric stratification on the level-crossing statistics has been studied in detail. It is shown that the effect of increasing atmospheric stability on level-crossing statistics is similar to the effect of increasing distance from the source in the sense that level-crossing statistics of concentration fluctuations in stable stratification resemble those in neutral stratification, but at a greater downwind distance. It is also found that the distribution of the interval between consecutive upcrossings of a concentration level, as well as the duration of an excursion across a concentration level, can be approximated by a lognormal distribution, whereas the distribution of the concentration amplitude is best characterized by a gamma distribution. Some implications of these results for the modeling of level-crossing statistics of concentration fluctuations are discussed. C1 KOSTENIUK CONSULTING LTD,SASKATOON,SK S7K 0H2,CANADA. S & J ENGN INC,SCARBOROUGH,ON M1V 3S1,CANADA. USA,MATERIEL TEST DIRECTORATE,DIV METEOROL,DUGWAY PROVING GROUND,UT 84022. RP YEE, E (reprint author), DEF RES ESTAB SUFFIELD,BOX 4000,MEDICINE HAT,AB T1A 8K6,CANADA. NR 22 TC 13 Z9 13 U1 0 U2 1 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0006-8314 J9 BOUND-LAY METEOROL JI Bound.-Layer Meteor. PD FEB PY 1995 VL 73 IS 1-2 BP 53 EP 90 DI 10.1007/BF00708930 PG 38 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA QW564 UT WOS:A1995QW56400004 ER PT J AU BRANNON, JM PENNINGTON, JC DAVIS, WM HAYES, C AF BRANNON, JM PENNINGTON, JC DAVIS, WM HAYES, C TI FLUORANTHENE K-DOC IN SEDIMENT PORE WATERS SO CHEMOSPHERE LA English DT Article ID DISSOLVED HUMIC MATERIALS; ORGANIC-MATTER; AROMATIC-HYDROCARBONS; SORPTION; CHEMICALS; CARBON; BIOAVAILABILITY; POLLUTANTS; TRANSPORT; BINDING AB When calculating concentrations of truly dissolved hydrophobic organic contaminants (HOCs) in sediment pore water, a common assumption is that the partition coefficient between pore water and colloidal plus dissolved organic carbon (K-DOC) equals the partition coefficient between pore water and sediment total organic carbon (K-DOC). This study examined the K-DOC of fluoranthene in pore water from 11 sediments. Truly dissolved fluoranthene was separated from DOG-associated fluoranthene by partitioning on C-18 Sep Paks. Measured values of K-DOC were not constant over the 11 sediments examined, and were over or underestimated by assuming that K-DOC = K-oc. Current models used to predict the fate of HOCs may require modification to account for the observed difference between K-DOC and K-OC. C1 ASCI CORP, MCLEAN, VA 22101 USA. RP BRANNON, JM (reprint author), USA, ENGINEER WATERWAYS EXPT STN, 3909 HALLS FERRY RD, VICKSBURG, MS 39181 USA. NR 24 TC 13 Z9 13 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD FEB PY 1995 VL 30 IS 3 BP 419 EP 428 DI 10.1016/0045-6535(94)00421-P PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA QG653 UT WOS:A1995QG65300002 ER PT J AU PENNINGTON, JC HAYES, CA MYERS, KF OCHMAN, M GUNNISON, D FELT, DR MCCORMICK, EF AF PENNINGTON, JC HAYES, CA MYERS, KF OCHMAN, M GUNNISON, D FELT, DR MCCORMICK, EF TI FATE OF 2,4,6-TRINITROTOLUENE IN A SIMULATED COMPOST SYSTEM SO CHEMOSPHERE LA English DT Article AB Composting of 2,4,6-trinitrotoluene (TNT) contaminated soils is a potentially economical remediation alternative. To determine whether environmentally undesirable emissions or residuals are produced, an explosives contaminated soil was amended with radiolabelled TNT before composting in a small-scale compost simulation system. Mass balance results indicated that TNT was not mineralized to volatile organic compounds and almost no radiolabelled CO2 was produced. Only transformation to the solvent extractable products, 4-amino-2,6-dinitrotoluene and 2-amino-4,6-dinitrotoluene, and conjugation to cellulosic, humin, humic acid and fulvic acid occurred. More than half of the added radioactivity was recovered in the cellulose plus humin fractions. C1 AMER SCI INT CORP,MCLEAN,VA 22101. RP PENNINGTON, JC (reprint author), USA,ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 9 TC 61 Z9 62 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD FEB PY 1995 VL 30 IS 3 BP 429 EP 438 DI 10.1016/0045-6535(94)00422-Q PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA QG653 UT WOS:A1995QG65300003 ER PT J AU DILLARD, TA MOORES, LK BILELLO, KL PHILLIPS, YY AF DILLARD, TA MOORES, LK BILELLO, KL PHILLIPS, YY TI THE PREFLIGHT EVALUATION - A COMPARISON OF THE HYPOXIA INHALATION TEST WITH HYPOBARIC EXPOSURE SO CHEST LA English DT Article DE ALTITUDE; CHRONIC OBSTRUCTIVE PULMONARY DISEASE; EMPHYSEMA; HYPOXEMIA; HYPOXIA ID OBSTRUCTIVE PULMONARY-DISEASE; AIR-TRAVEL; HYPOXEMIA AB Study objective: We sought to compare arterial oxygen partial pressure (PaO2) relationships between a 15.1% hypoxia inhalation test (HIT) at sea level and a hypobaric chamber exposure equivalent to 2,438 m (8,000 feet) of altitude above sea level in patients with chronic obstructive pulmonary disease (COPD) and healthy subjects. Design: Comparison of physiologic variables before and during intervention. Setting: A referral-based pulmonary disease clinic at a US Army medical center in a metropolitan area. Subjects: The study included three groups: group 1, 15 patients, 3 women and 12 men, with COPD (forced expiratory volume in the first second [FEV(1), mean +/- SD], 41 +/- 14% of predicted); group 2, 9 healthy men; and group 3, 18 men with COPD (FEV(1), 31 +/- 10% of predicted) previously reported in detail. Interventions: We evaluated each group at sea level followed by one of two different types of hypoxic exposures. Group 1 received exposure to 15.1%, oxygen at sea level, the HIT. Groups 2 and 3 received hypobaric chamber exposure equivalent to 2,438 m (8,000 feet) above sea level. Measurements and main results: For all three groups combined, the arterial oxygen tension at sea level (PaO2SL) explained significant variability in PaO2 during hypoxic exposure according to the following formula: PaO2 during exposure = 0.417 (PaO2SL)] +/- 17.802 (n = 42; r = 0.756; p < 0.001). Neither the type of hypoxic exposure (HIT vs hypobaric), status as patient vs control, sex, nor age explained significant variability in PaO2 during hypoxia exposure after inclusion of PaO2SL, as a covariate in analysis of variance. Subsequent analysis revealed that forced expiratory spirometric variables FEV(1) and FEV(1) to FVC ratio served as second order covariates with PaO2SL to improve description of PaO2 during hypoxia exposure for the combined samples (n = 42; p < 0.05). Analysis of residuals from regression analysis revealed approximately normal distribution. Conclusions: The PaO2 relationships did not differ between the 15.1% HIT at sea level and hypobaric exposures of 2,438 m (8,000 feet) above sea level. Normal subjects and patients with COPD formed a single relationship. The present study extends descriptive models to a larger range of subjects. Regression models have definable accuracy in predicting PaO2 during hypoxia exposure that increases with inclusion of spirometric variables. C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. MADIGAN ARMY MED CTR,TACOMA,WA 98431. RP DILLARD, TA (reprint author), WALTER REED ARMY MED CTR,DEPT MED,PULM FUNCT LAB,WARD 77,ROOM 7735,BLDG 2,WASHINGTON,DC 20307, USA. NR 12 TC 66 Z9 68 U1 2 U2 2 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD FEB PY 1995 VL 107 IS 2 BP 352 EP 357 DI 10.1378/chest.107.2.352 PG 6 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA QG122 UT WOS:A1995QG12200015 PM 7842760 ER PT J AU THEOCHARIS, S SFIKAKIS, PP LIPNICK, RN KLIPPLE, GL STEINBERG, AD TSOKOS, GC AF THEOCHARIS, S SFIKAKIS, PP LIPNICK, RN KLIPPLE, GL STEINBERG, AD TSOKOS, GC TI CHARACTERIZATION OF IN-VIVO MUTATED T-CELL CLONES FROM PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS SO CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY LA English DT Article ID ANTI-DNA AUTOANTIBODIES; MYELIN BASIC-PROTEIN; SECRETING B-CELLS; X-SWR MODEL; MULTIPLE-SCLEROSIS; LYMPHOCYTES-T; HELPER CELLS; 6-THIOGUANINE-RESISTANT LYMPHOCYTES; SOMATIC MUTATIONS; PERIPHERAL-BLOOD AB Patients with systemic lupus erythematosus (SLE) have increased percentages of activated T cells and increased numbers of cells with mutations in their hypoxanthine-guanine phosphoribosyltransferase (hprt) gene, as judged by growth in the presence of 6-thioguanine. To study the relevance of these mutant T cells to disease pathogenesis, we have assessed the phenotype and functional capabilities of such cells from 21 patients with SLE who never had received cytotoxic drugs. The frequency of T cells with mutations in hprt in the blood of these patients ranged from normal to 25 times normal (mean +/- SEM [21.1 +/- 6.1] x 10(-6) versus [4.8 +/- 0.8] x 10(-6), in 15 age-matched normal individuals, P < 0.001) and correlated significantly with disease duration. CD4(+) and CD8(+) phenotypes were comparable among mutated and nonmutated clones from both patients and normals. Although the frequency of CD3(+)CD4(-)CD8(-) cells was low, it was increased among SLE-derived T cells (mutated and wild-type) compared with clones derived from normals (5% for SLE vs 1% for normals). A substantial percentage of all clones were able to help autologous B cells to produce anti-ssDNA, 11 of 68 (16%) selected clones and 3 of 28 (11%) nonselected clones. Help for autoantibody production was confined to CD4(+) SLE-derived T cell clones. It could be blocked using an anti-HLA-DR mAb, suggesting that classical cognate help was operative. This represents the first estimate of the frequency of T cells able to drive autoantibody production in SLE. (C) 1995 Academic Press, Inc. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. MITRE CORP,MCLEAN,VA 22102. RP THEOCHARIS, S (reprint author), WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307, USA. NR 46 TC 32 Z9 32 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 SN 0090-1229 J9 CLIN IMMUNOL IMMUNOP JI Clin. Immunol. Immunopathol. PD FEB PY 1995 VL 74 IS 2 BP 135 EP 142 DI 10.1006/clin.1995.1020 PG 8 WC Immunology; Pathology SC Immunology; Pathology GA QD308 UT WOS:A1995QD30800003 PM 7828367 ER PT J AU CANTILENA, LR SORRELS, S WILEY, T WORTHAM, D AF CANTILENA, LR SORRELS, S WILEY, T WORTHAM, D TI FLUCONAZOLE ALTERS TERFENADINE PHARMACOKINETICS AND ELECTROCARDIOGRAPHIC PHARMACODYNAMICS SO CLINICAL PHARMACOLOGY & THERAPEUTICS LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,DIV CLIN PHARMACOL,BETHESDA,MD. WALTER REED ARMY MED CTR,DEPT CARDIOL,WASHINGTON,DC. NR 0 TC 12 Z9 12 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0009-9236 J9 CLIN PHARMACOL THER JI Clin. Pharmacol. Ther. PD FEB PY 1995 VL 57 IS 2 BP 185 EP 185 PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA QJ312 UT WOS:A1995QJ31200199 ER EF