FN Thomson Reuters Web of Science™ VR 1.0 PT J AU PEDERSEN, AM TAYLOR, BK PAYNE, AM ABDELRAHIM, M FRANCIS, GL AF PEDERSEN, AM TAYLOR, BK PAYNE, AM ABDELRAHIM, M FRANCIS, GL TI MACROPHAGE CONDITIONED MEDIA AFFECTS STEROID-HORMONE PRODUCTION BY PLACENTAL CULTURES SO ANNALS OF CLINICAL AND LABORATORY SCIENCE LA English DT Article ID TUMOR-NECROSIS-FACTOR; PRETERM LABOR; AMNIOTIC-FLUID; PROSTAGLANDIN BIOSYNTHESIS; INTRAAMNIOTIC INFECTION; HUMAN PARTURITION; DECIDUAL CELLS; LEYDIG-CELLS; INTERLEUKIN-1; SECRETION AB Placental steroid hormone production appears to be critical in maintaining pregnancy and possibly initiating parturition. Cytokines, produced by activated macrophages and decidua, are present during delivery, but their role in this process is not yet clear. To our knowledge, only one recent study, which used JEG-3 choriocarcinoma cells as an in vitro model, has evaluated the possibility that cytokines might affect placental steroidogenesis. Our current study reports observations on the effect of macrophage conditioned media (MCM, known to contain several cytokines) on the synthesis of progesterone and estradiol by term, normal, human placenta. Macrophage conditioned media significantly decreased progesterone (36 percent) and increased estradiol (76 percent) production by short-term placental organ cultures. these results suggest that macrophage secretory products might significantly alter placental steroidogenesis which could make them important factors in the physiology of parturition. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 34 TC 6 Z9 6 U1 0 U2 0 PU INST CLINICAL SCIENCE INC PI PHILADELPHIA PA 1833 DELANCEY PLACE, PHILADELPHIA, PA 19103 SN 0091-7370 J9 ANN CLIN LAB SCI JI Ann. Clin. Lab. Sci. PD NOV-DEC PY 1994 VL 24 IS 6 BP 548 EP 554 PG 7 WC Medical Laboratory Technology SC Medical Laboratory Technology GA PN372 UT WOS:A1994PN37200009 PM 7847783 ER PT J AU KALCHAYANAND, N SIKES, T DUNNE, CP RAY, B AF KALCHAYANAND, N SIKES, T DUNNE, CP RAY, B TI HYDROSTATIC-PRESSURE AND ELECTROPORATION HAVE INCREASED BACTERICIDAL EFFICIENCY IN COMBINATION WITH BACTERIOCINS SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Note ID LACTIC-ACID BACTERIA; PEDIOCOCCUS-ACIDILACTICI; SUBLETHAL INJURY; PEDIOCIN ACH AB WE report here that both ultrahigh hydrostatic pressure (UHP) and electroporation (EP) induced sublethal injury to bacterial cells surviving the treatments. The injured cells of both gram-positive and -negative bacteria became sensitive to the bacteriocins pediocin AcH and nisin. Bacteriocins in combination with either UHP or EP have greater antibacterial effectiveness than UHP or EP alone. C1 UNIV WYOMING,DEPT ANIM SCI,FOOD MICROBIOL LAB,LARAMIE,WY 82071. USA,NATICK RES DEV & ENGN CTR,SUSTAINABIL DIRECTORATE,NATICK,MA 01760. NR 24 TC 138 Z9 142 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD NOV PY 1994 VL 60 IS 11 BP 4174 EP 4177 PG 4 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA PP139 UT WOS:A1994PP13900043 PM 16349445 ER PT J AU RACINE, CH WALTERS, JC AF RACINE, CH WALTERS, JC TI GROUNDWATER-DISCHARGE FENS IN THE TANANA LOWLANDS, INTERIOR ALASKA USA SO ARCTIC AND ALPINE RESEARCH LA English DT Article ID VEGETATION; GRADIENTS; ALBERTA AB Large expanses of herbaceous floating mat wetlands (FMW) bordered by slightly higher uplands with forest or scrub occur in the northwest corner of the Tanana Flats between the Alaska Range and the Tanana. River. Five major FMW systems, together with other outliers and extensions, are linear in shape and cover over 20 km(2). Nutrient-rich and circumneutral water flows slowly through these areas toward the northwest and through outlets to the Tanana River. The floating mat vegetation consists of tall emergent macrophytes; mosses, in particular Sphagnum spp., are conspicuously absent and shrubs are infrequent. Although species dominance shifts over short distances on the mat, four community types can be recognized: (1) Menyanthes trifoliata, (2) Carex aquatilis, (3) Typha latifolia, and (4) Calla palustris. Below the water surface, the mat extends to a depth of 0.5 to 1.0 m and consists of rhizomes and roots in a matrix of well-decomposed peat and water. The mat then either directly overlies unfrozen gray silts at a depth of 1 m, or more commonly, floats on a clear-water or loose peat zone above more consolidated peat lying on unfrozen silt at a depth of 1.5 to 2.5 m. No permafrost or frozen ground was detected in late August or late winter below these floating mats but it is ubiquitous on the bordering uplands, 0.5 to 2 m above the FMW. The topographic location, apparent absence of permafrost, water chemistry, and vegetation composition suggest that these areas are fens fed by groundwater sources flowing out of the Alaska Range. Permafrost degradation and lateral expansion of these FMW is indicated by slumped blocks of forest pear, dead trees, and open water moats along the upland margin. Although floating mats are frequently described in the literature as occupying the edge of northern ponds and lakes, the FMW described here do not and they appear to be unique because of their large extent, absence of mosses, physiographic position, and presumed origin. C1 UNIV NO IOWA,DEPT EARTH SCI,CEDAR FALLS,IA 50614. RP RACINE, CH (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 25 TC 21 Z9 21 U1 0 U2 7 PU INST ARCTIC ALPINE RES PI BOULDER PA UNIV COLORADO, BOULDER, CO 80309 SN 0004-0851 J9 ARCTIC ALPINE RES JI Arct. Alp. Res. PD NOV PY 1994 VL 26 IS 4 BP 418 EP 426 DI 10.2307/1551804 PG 9 WC Environmental Sciences; Geography SC Environmental Sciences & Ecology; Geography GA PT769 UT WOS:A1994PT76900013 ER PT J AU CRAIG, SC AF CRAIG, SC TI THE LIFE OF BRIGADIER GENERAL LYSTER,THEODORE,C SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Item About an Individual AB Theodore C. Lyster is a familiar name to aerospace medicine physicians. His early recognition of the unique physical requirements of aviators, the specialized training necessary for flight surgeons, and the need for altitude physiology research provided the foundation on which the specialty of aviation medicine was built. Lyster's medical career, however, encompassed much more than aviation medicine. From his earliest assignment as a contract physician in Cuba in 1899 until his entry into private practice in 1921, he was heavily involved with the fight against yellow fever. In the era before medical residencies were commonplace, Lyster sought out training in ophthalmology and oto laryngology in the U.S. and abroad. His clinical and organizational abilities made him a valuable asset during the construction of the Panama Canal and during World War I. Lyster's many talents and his philosophy about aviation medicine make him a worthy role model for flight surgeons today. C1 WOMACK ARMY MED CTR,PREVENT MED SERV,FT BRAGG,NC. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD NOV PY 1994 VL 65 IS 11 BP 1047 EP 1053 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA PQ628 UT WOS:A1994PQ62800012 PM 7840746 ER PT J AU ELSMORE, TF AF ELSMORE, TF TI SYNWORK1 - A PC-BASED TOOL FOR ASSESSMENT OF PERFORMANCE IN A SIMULATED WORK-ENVIRONMENT SO BEHAVIOR RESEARCH METHODS INSTRUMENTS & COMPUTERS LA English DT Article ID TEST BATTERIES; MILLISECOND AB SYNWORK1 is a computer-based performance task that requires subjects to work simultaneously on four distinct subtasks involving memory, arithmetic processing, and visual and auditory monitoring. Difficulty levels, the payoff matrix, feedback levels, and component subtask mix are user selectable. Detailed data are automatically collected, and a suite of data analysis programs is available. SYNWORK1 is being used in sleep-deprivation and circadian desynchronization experiments and in a variety of clinical research applications. Representative data from a sleep-deprivation experiment are presented to demonstrate the sensitivity of the technique. The strategy used for programming concurrent tasks on a PC is described. C1 USN,HLTH RES CTR,SAN DIEGO,CA 92152. RP ELSMORE, TF (reprint author), WALTER REED ARMY INST RES,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307, USA. NR 18 TC 51 Z9 51 U1 0 U2 1 PU PSYCHONOMIC SOC INC PI AUSTIN PA 1710 FORTVIEW RD, AUSTIN, TX 78704 SN 0743-3808 J9 BEHAV RES METH INSTR JI Behav. Res. Methods Instr. Comput. PD NOV PY 1994 VL 26 IS 4 BP 421 EP 426 DI 10.3758/BF03204659 PG 6 WC Psychology, Mathematical; Psychology, Experimental SC Psychology GA PT270 UT WOS:A1994PT27000007 ER PT J AU SHUKITTHALE, B STILLMAN, MJ WELCH, DI LEVY, A DEVINE, JA LIEBERMAN, HR AF SHUKITTHALE, B STILLMAN, MJ WELCH, DI LEVY, A DEVINE, JA LIEBERMAN, HR TI HYPOBARIC HYPOXIA IMPAIRS SPATIAL MEMORY IN AN ELEVATION-DEPENDENT FASHION SO BEHAVIORAL AND NEURAL BIOLOGY LA English DT Article ID MORRIS WATER MAZE; HIPPOCAMPAL DAMAGE; FOREBRAIN ISCHEMIA; WORKING MEMORY; PERFORMANCE; ACETYLCHOLINE; PIRENZEPINE; ALTITUDE; BLOCKADE; DEFICITS AB The effects of various levels of hypobaric hypoxia, exposure to reduced atmospheric pressure, on spatial memory in rats were examined. Hypobaric hypoxia simulates high altitude conditions where substantial deficits in human cognitive performance occur. However, few studies have measured cognitive changes in animals during exposure to this type of hypoxia. Male Fischer 344 rats were tested in the learning set version of the Morris water maze, a test known to assess spatial memory. Rats were tested at 2 and 6 hours while exposed to a range of simulated altitudes: sea level, 5500 in, 5950 m, and 6400 m. Altitude exposures at 5950 or 6400 m decreased both reference and working memory performance, as demonstrated by latency, distance, and. speed measures, in an elevation-dependent fashion. During sea level testing on the day following hypobaric exposure, decrements in reference memory were still observed on all dependent measures, but only speed was impaired on the working memory task. These results agree with human studies that demonstrate elevation-dependent impairments in spatial memory performance during exposure to hypobaric hypoxia. The deficits may be attributable to changes in hippocampal cholinergic function. (C) 1994 Academic Press, Inc. C1 USA,ENVIRONM MED RES INST,DIV MIL PERFORMANCE & NEUROSCI,NATICK,MA 01760. GEOCENTERS INC,NEWTON,MA 02159. BOSTON UNIV,DEPT PSYCHOL,BOSTON,MA 02215. ISRAEL INST BIOL RES,DEPT PHARMACOL,NESS ZIONA,ISRAEL. NR 29 TC 43 Z9 48 U1 0 U2 2 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0163-1047 J9 BEHAV NEURAL BIOL JI Behav. Neural Biol. PD NOV PY 1994 VL 62 IS 3 BP 244 EP 252 DI 10.1016/S0163-1047(05)80023-8 PG 9 WC Behavioral Sciences; Neurosciences; Psychology SC Behavioral Sciences; Neurosciences & Neurology; Psychology GA PP755 UT WOS:A1994PP75500009 PM 7857247 ER PT J AU SMITH, JD PATTERSON, CH ALFEROS, CD PINTO, DC CHIANG, PK AF SMITH, JD PATTERSON, CH ALFEROS, CD PINTO, DC CHIANG, PK TI EFFECT OF PHOSPHATIDYLCHOLINE ON PHOSPHATIDYLCHOLINE BIOSYNTHESIS IN TETRAHYMENA - DIFFERENTIAL RESPONSES TO INHIBITION BY THE S-ADENOSYLHOMOCYSTEINE ANALOGS 5'-DEOXY-5'-ISOBUTYLTHIOADENOSINE (SIBA) AND 5'-DEOXY-5'-ISOBUTYLTHIO-3-DEAZAADENOSINE (DZ-SIBA) SO BIOCHEMICAL ARCHIVES LA English DT Article ID PHOSPHOLIPID-METABOLISM; CDP-CHOLINE; PHOSPHONIC ACID; N-METHYLATION; RAT-LIVER; PHOSPHATIDYLETHANOLAMINE; ETHANOLAMINE; 3-DEAZAADENOSINE; CELLS AB Exposure of Tetrahymena to high doses of the S-adenosylhomocysteine analogues SIBA(4) and dz-SIBA leads to strong growth inhibition, abnormal cell morphology and inhibition of phosphatidylcholine formation both by methylation of phosphatidylethanolamine and by incorporation of choline via the cholinephosphotransferase pathway, as determined by measuring alterations in the relative incorporation of [H-3-CH3]choline and [C-14-CH3]methionine into the phospholipids of the organism during growth. Inclusion of phosphatidylcholine or choline in the growth medium with dz-SIBA reverses the morphological distortions but only phosphatidylcholine reverses the growth inhibition as well. By contrast, the growth inhibition produced by SIBA is not reversed by phosphatidylcholine, indicating that the two inhibitors produce their effects by different processes. Growth of uninhibited cells with phosphatidylcholine results in significant reduction in both choline and methionine incorporation into phosphatidylcholine and an increase in cellular phosphatidylcholine content from approximately 15% to 40% of the total cellular phospholipids pointing to direct uptake of the intact phospholipid. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC 20307. RP SMITH, JD (reprint author), UNIV MASSACHUSETTS,DEPT CHEM,N DARTMOUTH,MA 02747, USA. NR 24 TC 0 Z9 0 U1 0 U2 0 PU MBR PRESS INC PI KENYON PA PO BOX P, KENYON, MN 55946-000P SN 0749-5331 J9 BIOCHEM ARCH JI Biochem. Arch. PD NOV PY 1994 VL 10 IS 4 BP 303 EP 309 PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA PR348 UT WOS:A1994PR34800013 ER PT J AU HWANG, HM LOYA, JA PERRY, DL SCHOLZE, R AF HWANG, HM LOYA, JA PERRY, DL SCHOLZE, R TI INTERACTIONS BETWEEN SUBSURFACE MICROBIAL ASSEMBLAGES AND MIXED ORGANIC AND INORGANIC CONTAMINANT SYSTEMS SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article ID GROUND-WATER; ADAPTATION; DEGRADATION; SITE C1 UNIV CALIF BERKELEY,LAWRENCE BERKELEY LAB,BERKELEY,CA 94720. USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61824. RP HWANG, HM (reprint author), JACKSON STATE UNIV,DEPT BIOL,JACKSON,MS 39217, USA. FU NIGMS NIH HHS [SO6GM08047] NR 14 TC 3 Z9 5 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0007-4861 J9 B ENVIRON CONTAM TOX JI Bull. Environ. Contam. Toxicol. PD NOV PY 1994 VL 53 IS 5 BP 771 EP 778 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA PH793 UT WOS:A1994PH79300021 PM 7833616 ER PT J AU CARDELLO, AV AF CARDELLO, AV TI FOOD, HEALTH, AND SENSORY EVALUATION IN THE NEW-AGE SO CEREAL FOODS WORLD LA English DT Article ID INTENTIONS; SELECTION; ATTITUDES; NORMS RP CARDELLO, AV (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 13 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CEREAL CHEMISTS PI ST PAUL PA 3340 PILOT KNOB RD, ST PAUL, MN 55121-2097 SN 0146-6283 J9 CEREAL FOOD WORLD JI Cereal Foods World PD NOV-DEC PY 1994 VL 39 IS 11 BP 877 EP 879 PG 3 WC Food Science & Technology SC Food Science & Technology GA PX977 UT WOS:A1994PX97700012 ER PT J AU MACKOWIAK, PA WASSERMAN, SS TACKET, CO VAUGHN, DW ECKELS, KH DUBOIS, DR HOKE, CH EDELMAN, R AF MACKOWIAK, PA WASSERMAN, SS TACKET, CO VAUGHN, DW ECKELS, KH DUBOIS, DR HOKE, CH EDELMAN, R TI QUANTITATIVE RELATIONSHIP BETWEEN ORAL-TEMPERATURE AND SEVERITY OF ILLNESS FOLLOWING INOCULATION WITH CANDIDATE ATTENUATED DENGUE VIRUS-VACCINES SO CLINICAL INFECTIOUS DISEASES LA English DT Note AB The relationship between oral temperature and other parameters of illness was examined in 51 adult volunteers who were inoculated experimentally with partially attenuated candidate dengue virus vaccines. In subjects who developed clinical illness, the peak illness temperature, mean illness temperature, and peak 6:00 A.M. illness temperature all correlated positively with the total number of signs and symptoms other than fever and with a fall in the white blood cell count (the latter was the only laboratory abnormality significantly associated with clinical illness [P = .02]). Of these factors, the peak 6:00 A.M. Oral temperature exhibited the strongest correlations with the two parameters used to estimate severity of illness (r(xy) = .58 and P < .01 for signs and symptoms; r(xy) = .37 and P = .01 for fall in white blood cell count). C1 UNIV MARYLAND,SCH MED,DEPT MED,CTR VACCINE DEV,BALTIMORE,MD. WALTER REED ARMY INST RES,DEPT VIRUS DIS,WASHINGTON,DC. WALTER REED ARMY INST RES,DEPT BIOL RES,WASHINGTON,DC. RP MACKOWIAK, PA (reprint author), DEPT VET AFFAIRS MED CTR,MED SERV 111,10 N GREENE ST,BALTIMORE,MD 21201, USA. NR 8 TC 6 Z9 7 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD NOV PY 1994 VL 19 IS 5 BP 948 EP 950 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA PT713 UT WOS:A1994PT71300024 PM 7893886 ER PT J AU ABBOTT, KC WORTHAM, WG AF ABBOTT, KC WORTHAM, WG TI ULTRASONOGRAPHIC UNILATERAL HYDRONEPHROSIS WITH BLADDER OUTLET OBSTRUCTION SO CLINICAL NEPHROLOGY LA English DT Note DE ULTRASONOGRAPHY; UNILATERAL HYDRONEPHROSIS; BLADDER OUTLET OBSTRUCTION ID AZOTEMIC PATIENTS; US; ULTRASOUND AB Renal ultrasonography plays an important role in the evaluation of azotemic patients. Knowledge of its limitations is crucial for the proper evaluation of obstructive uropathy. Two cases are presented in which screening ultrasonography detected unilateral hydronephrosis despite lower urinary tract obstruction. Both patients had markedly asymmetrical renal function, with the hydronephrosis found in the better functioning kidney. The importance of searching for asymmetry of renal function in the azotemic patient with atypical ultrasonogram findings is emphasized. Other clinical factors which would heighten suspicion for obstructive uropathy and lead to further investigation despite a minimally abnormal or even normal renal ultrasonogram are also discussed. RP ABBOTT, KC (reprint author), BROOKE ARMY MED CTR,SERV NEPHROL,FT SAM HOUSTON,TX 78234, USA. OI Abbott, Kevin/0000-0003-2111-7112 NR 10 TC 0 Z9 0 U1 0 U2 0 PU DUSTRI-VERLAG DR KARL FEISTLE PI MUNCHEN-DEISENHOFEN PA BAHNHOFSTRABE 9 POSTFACH 49, W-8024 MUNCHEN-DEISENHOFEN, GERMANY SN 0301-0430 J9 CLIN NEPHROL JI Clin. Nephrol. PD NOV PY 1994 VL 42 IS 5 BP 337 EP 340 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA PT831 UT WOS:A1994PT83100011 PM 7851037 ER PT J AU NAKANO, Y AF NAKANO, Y TI QUASI-STEADY PROBLEMS IN FREEZING SOILS .4. TRAVELING-WAVE SOLUTIONS SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article ID ICE LAYER; GROWTH AB A mathematical model of a frozen fringe called M(1) was introduced (Nakano, 1990). The results of mathematical and experimental studies presented in preceding papers (Nakano, 1990; Takeda and Nakano, 1990; Nakano and Takeda, 1991) clearly show that the model M(1) accurately describes the properties of a frozen fringe when the steady growth of an ice layer occurs. In this work the steady growth of ice-rich frozen soil is studied by using M(1). Deriving a traveling wave solution to the problem, we have found that the condition of steady growth of ice-rich frozen soil is uniquely determined by a set of two physical variables, such as alpha(0) and alpha(1) used earlier (Nakano, 1990), under given hydraulic conditions and overburden pressures and that the traveling wave solution converges to the solution to the problem of a steadily growing ice layer when the velocity of the 0 degrees C isotherm relative to the unfrozen part of the soil vanishes. RP NAKANO, Y (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 10 TC 2 Z9 3 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD NOV PY 1994 VL 23 IS 1 BP 1 EP 17 DI 10.1016/0165-232X(94)90009-4 PG 17 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA PX247 UT WOS:A1994PX24700001 ER PT J AU DAYTON, DC FAUST, CM ANDERSON, WR SAUSA, RC AF DAYTON, DC FAUST, CM ANDERSON, WR SAUSA, RC TI FLAME STRUCTURE STUDY OF A LEAN H-2/N2O/AR FLAME EMPLOYING MOLECULAR-BEAM MASS-SPECTROMETRY AND MODELING SO COMBUSTION AND FLAME LA English DT Article; Proceedings Paper CT 25th International Symposium on Combustion CY JUL 31-AUG 05, 1994 CL IRVINE, CA ID SHOCK-TUBE; N2O-H2 REACTION; RATE CONSTANTS; COMBUSTION; MECHANISM; SYSTEMS AB A combined experimental and detailed modeling study has been performed on a fuel-lean (Phi = 0.64), 20-torr, low-pressure, burner-stabilized H-2/N2O/Ar flame. Species concentration and temperature profiles were obtained using molecular beam mass spectrometry and thin-wire Pt/Pt-Rh(10%) thermocouples, respectively. Species profiles include H-2, N2O, N-2, H2O, NO, O-2, H, O, and OH. These profiles are compared with calculated profiles generated using PREMIX, a one-dimensional premixed laminar flame code. The detailed chemical mechanism employed in the code consists of 38 reactions and 14 species, and was derived from preliminary calculations using a more comprehensive set of reactions (> 200) obtained from a critical literature review. Rate and sensitivity analyses were performed on the PREMIX results using an interactive postprocessing code we have written so that the details of the chemistry may be understood. The results provide a stringent test of the detailed chemical flame model and chemical mechanism for the H-2/N2O/Ar system. RP DAYTON, DC (reprint author), USA,RES LAB,AMSRL,WT,PC,ABERDEEN PROVING GROUND,MD 21005, USA. NR 27 TC 6 Z9 6 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0010-2180 J9 COMBUST FLAME JI Combust. Flame PD NOV PY 1994 VL 99 IS 2 BP 323 EP 330 DI 10.1016/0010-2180(94)90137-6 PG 8 WC Thermodynamics; Energy & Fuels; Engineering, Multidisciplinary; Engineering, Chemical; Engineering, Mechanical SC Thermodynamics; Energy & Fuels; Engineering GA PR020 UT WOS:A1994PR02000017 ER PT J AU KIMSEY, KD OLSON, MA AF KIMSEY, KD OLSON, MA TI PARALLEL COMPUTATION OF IMPACT DYNAMICS SO COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING LA English DT Article; Proceedings Paper CT Symposium on Parallel Finite Element Computations CY OCT 25-27, 1993 CL UNIV MINNESOTA, SUPERCOMP INST, MINNEAPOLIS, MN SP UNIV MINNESOTA, ARMY HIGH PERFORMANCE COMP RES CTR, UNIV MINNESOTA, SUPERCOMP INST HO UNIV MINNESOTA, SUPERCOMP INST AB This paper discusses a parallel algorithm and data structures for implementing multimaterial, two-step Eulerian finite difference solution schemes on hypercube architectures. Selected problems in impact dynamics have been modeled on the Connection Machine model CM5, and the results are compared with computational results reported in the literature, as well as direct comparison with experimental data. RP KIMSEY, KD (reprint author), USA,RES LAB,WEAP TECHNOL DIRECTORATE,ABERDEEN PROVING GROUND,MD 21005, USA. NR 20 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0045-7825 J9 COMPUT METHOD APPL M JI Comput. Meth. Appl. Mech. Eng. PD NOV PY 1994 VL 119 IS 1-2 BP 113 EP 121 DI 10.1016/0045-7825(94)00079-4 PG 9 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Engineering; Mathematics; Mechanics GA PV586 UT WOS:A1994PV58600008 ER PT J AU SALINGER, AG XIAO, Q ZHOU, YM DERBY, JJ AF SALINGER, AG XIAO, Q ZHOU, YM DERBY, JJ TI MASSIVELY-PARALLEL FINITE-ELEMENT COMPUTATIONS OF 3-DIMENSIONAL, TIME-DEPENDENT, INCOMPRESSIBLE FLOWS IN MATERIALS PROCESSING SYSTEMS SO COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING LA English DT Article ID CRYSTAL-GROWTH; CONNECTION MACHINE; HEAT-TRANSFER; EQUATIONS; ALGORITHM AB A parallel implementation of the Galerkin finite element method for three-dimensional, incompressible flows is presented. The inherent element-by-element parallelism of the method is exploited to make efficient use of the architecture of the CM-5 computer. Our implementation features a mixed formulation to expand the primitive variables using triquadratic brick elements with linear, discontinuous pressure basis functions, and the GMRES method with diagonal preconditioning is employed to solve the linear system at each Newton iteration. Transitions among flow states in the classical Taylor-Couette system, which are representative of the complexity of flows found in materials processing systems, are computed as benchmark solutions, and preliminary results are presented for flow in a large-scale, solution crystal growth system. Sustained calculation rates of up to 6 GigaFLOPS are achieved on 512 processors of the CM-5. C1 UNIV MINNESOTA, DEPT CHEM ENGN & MAT SCI, MINNEAPOLIS, MN 55455 USA. UNIV MINNESOTA, ARMY HIGH PERFORMANCE COMP RES CTR, MINNEAPOLIS, MN 55455 USA. RI Derby, Jeffrey/B-9706-2009; OI Derby, Jeffrey/0000-0001-6418-2155 NR 54 TC 35 Z9 35 U1 0 U2 2 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0045-7825 J9 COMPUT METHOD APPL M JI Comput. Meth. Appl. Mech. Eng. PD NOV PY 1994 VL 119 IS 1-2 BP 139 EP 156 DI 10.1016/0045-7825(94)00081-6 PG 18 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Engineering; Mathematics; Mechanics GA PV586 UT WOS:A1994PV58600010 ER PT J AU BURGESS, JT SMITH, WB KEELING, JH AF BURGESS, JT SMITH, WB KEELING, JH TI SEBORRHEIC KERATOSIS WITH TRICHILEMMOMAS MASQUERADING AS MELANOMA SO CUTIS LA English DT Article ID SQUAMOUS-CELL CARCINOMA; INSITU AB Seborrheic keratoses are benign lesions and, generally, are easily diagnosed based on clinical criteria. However, several types of benign as well as malignant lesions have been found associated with seborrheic keratoses, thus confusing the clinical picture. Presented is the first reported case of trichilemmomas occurring within seborrheic keratosis and masquerading as melanoma with regression. Biopsy of unusual seborrheic keratoses is recommended. C1 BROOKE ARMY MED CTR,DEPT MED,DERMATOL SERV,FT SAM HOUSTON,TX 78234. NR 13 TC 4 Z9 4 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0011-4162 J9 CUTIS JI Cutis PD NOV PY 1994 VL 54 IS 5 BP 351 EP 353 PG 3 WC Dermatology SC Dermatology GA PT907 UT WOS:A1994PT90700013 PM 7835066 ER PT J AU MAENO, Y FUJIOKA, H HOLLINGDALE, MR OCKENHOUSE, CF NAKAZAWA, S AIKAWA, M AF MAENO, Y FUJIOKA, H HOLLINGDALE, MR OCKENHOUSE, CF NAKAZAWA, S AIKAWA, M TI ULTRASTRUCTURAL-LOCALIZATION OF CD36 IN HUMAN HEPATIC SINUSOIDAL LINING CELLS, HEPATOCYTES, HUMAN HEPATOMA (HEPG2-A1G) CELLS, AND C32 AMELANOTIC MELANOMA-CELLS SO EXPERIMENTAL PARASITOLOGY LA English DT Article DE PLATELET GLYCOPROTEIN IV; HUMAN LIVER; HUMAN HEPATOMA CELL; C32 AMELANOTIC MELANOMA CELL; IMMUNOELECTRON MICROSCOPY ID FALCIPARUM-INFECTED ERYTHROCYTES; HUMAN CEREBRAL MALARIA; VEIN ENDOTHELIAL-CELLS; PLASMODIUM-FALCIPARUM; CIRCUMSPOROZOITE PROTEIN; ADHESION MOLECULE-1; SPOROZOITE INVASION; RECEPTOR; CYTOADHERENCE; MEMBRANE AB CD36 is expressed in the endothelial cells of some human organs, but the ultrastructural localization of this molecule in the sinusoidal lining cells of human liver is not well established. We report the ultrastructural localization of CD36 in the liver using a novel murine monoclonal antibody against CD36, namely MO30, as a primary antibody. Immunocytochemistry by the postembedding method showed that CD36 was localized in endothelial cells of sinusoids and in hepatocyte microvilli protruding into the space of Disse. Moreover, in cultured human hepatoma (HepG2-A16) cells and C32 amelanotic melanoma cells, MO30 reacted with microvilli. Hence, CD36 expressed on these cells may be involved in recognition and/or entry of these cells by malaria sporozoites. (C) 1994 Academic Press, Inc. C1 US FDA,CBER,ROCKVILLE,MD 20852. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307. RP MAENO, Y (reprint author), CASE WESTERN RESERVE UNIV,INST PATHOL,2085 ADELBERT RD,CLEVELAND,OH 44106, USA. FU NIAID NIH HHS [AI-10645-22] NR 27 TC 20 Z9 20 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0014-4894 J9 EXP PARASITOL JI Exp. Parasitol. PD NOV PY 1994 VL 79 IS 3 BP 383 EP 390 DI 10.1006/expr.1994.1100 PG 8 WC Parasitology SC Parasitology GA PR139 UT WOS:A1994PR13900016 PM 7525338 ER PT J AU NAKAZAWA, S BROWN, AE MAENO, Y SMITH, CD AIKAWA, M AF NAKAZAWA, S BROWN, AE MAENO, Y SMITH, CD AIKAWA, M TI MALARIA-INDUCED INCREASE OF SPLENIC GAMMA-DELTA T-CELLS IN HUMANS, MONKEYS, AND MICE SO EXPERIMENTAL PARASITOLOGY LA English DT Article DE SPLENIC GAMMA-DELTA T CELLS; PLASMODIUM FALCIPARUM; PLASMODIUM COATNEYI; PLASMODIUM CHABAUDI; IMMUNOFLUORESCENCE MICROSCOPY ID PLASMODIUM-FALCIPARUM MALARIA; LYMPHOCYTES-T; RECEPTOR; INFECTION; MOLECULE; BEARING; HETERODIMER; THYMOCYTES; EXPRESSION; ACTIVATION AB The number and distribution of gamma delta T cells in spleens from patients who died of cerebral malaria and from rhesus monkeys severely infected with Plasmodium coatneyi were examined by immunocytochemistry. gamma delta T cells were significantly increased in these spleens. In a rodent malaria model using Plasmodium chabaudi adami, an avirulent strain of murine malaria parasites, the degree of parasitemia appears to be modulated by the number of gamma delta T cells in the spleen. As parasitemia increases, these T cells increase in number. At some critical point, gamma delta T cells in collaboration with macrophages and alpha beta T cells apparently start to clear parasitized erythrocytes from the blood, leading to an abatement of the parasitemia, which is followed by a reduction in the number of gamma delta T cells. This gamma delta T cell phenomenon may be responsible for the self-limiting infection in mice. (C) 1994 Academic Press, Inc. C1 ARMED FORCES RES INST MED SCI,BANGKOK 10400,THAILAND. RP NAKAZAWA, S (reprint author), CASE WESTERN RESERVE UNIV,INST PATHOL,2085 ADELBERT RD,CLEVELAND,OH 44106, USA. FU NIAID NIH HHS [AI-10645] NR 25 TC 18 Z9 18 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0014-4894 J9 EXP PARASITOL JI Exp. Parasitol. PD NOV PY 1994 VL 79 IS 3 BP 391 EP 398 DI 10.1006/expr.1994.1101 PG 8 WC Parasitology SC Parasitology GA PR139 UT WOS:A1994PR13900017 PM 7957758 ER PT J AU CONDIE, LW LAUER, WC WOLFE, GW CZEH, ET BURNS, JM AF CONDIE, LW LAUER, WC WOLFE, GW CZEH, ET BURNS, JM TI DENVER POTABLE WATER REUSE DEMONSTRATION PROJECT - COMPREHENSIVE CHRONIC RAT STUDY SO FOOD AND CHEMICAL TOXICOLOGY LA English DT Article ID B6C3F1 MICE; HOMOGENEITY; PROPORTIONS; PROGRAM; TREND AB The health effects testing program for the Denver Water Department's Potable Water Reuse Demonstration Project was designed to evaluate the relative health effects of highly treated reclaimed water derived from secondary wastewater in comparison with Denver's present high-quality drinking water. The 1 x 10(6) gal/day treatment plant provided 500-fold concentrates of water that had been treated by multiple processes to remove microbial and chemical contaminants. Fischer 344 rats were exposed to the complex mixture solutions for up to 2 yr to evaluate chronic toxicity and oncogenicity effects. The following parameters were evaluated: clinical observations, survival rate, growth, food and water consumption, haematology, clinical chemistry, urinalysis, organ weights, gross autopsy and histopathological examination of all lesions, major tissues and organs. Clinical pathology, gross pathology, and microscopic pathology conducted at wk 26 and 65 and at the end of the study did not reveal any findings that could be considered to be treatment related. Administration of drinking water concentrates at up to 500 times the original concentration in the original water samples to F344 rats for up to 104 wk did not result in any overt toxicological or carcinogenic effects. C1 DENVER WATER DEPT,DENVER,CO 80254. HAZLETON WASHINGTON INC,VIENNA,VA 22182. RP CONDIE, LW (reprint author), USA,DUGWAY PROVING GROUND,STEDPMTC,DUGWAY PROVING GROUND,UT 84022, USA. NR 15 TC 7 Z9 8 U1 1 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0278-6915 J9 FOOD CHEM TOXICOL JI Food Chem. Toxicol. PD NOV PY 1994 VL 32 IS 11 BP 1021 EP 1030 DI 10.1016/0278-6915(94)90142-2 PG 10 WC Food Science & Technology; Toxicology SC Food Science & Technology; Toxicology GA PT680 UT WOS:A1994PT68000003 PM 7959456 ER PT J AU OCONNOR, CJ LEE, YS TANG, J JOHN, VT KOMMAREDDI, NS TATA, M MCPHERSON, GL AKKARA, JA KAPLAN, DL AF OCONNOR, CJ LEE, YS TANG, J JOHN, VT KOMMAREDDI, NS TATA, M MCPHERSON, GL AKKARA, JA KAPLAN, DL TI SUPERPARAMAGNETISM OF FERRITE PARTICLES DISPERSED IN SPHERICAL POLYMERIC MATERIALS SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT 6th Joint Magnetism and Magnetic Materials-Intermag Conference CY JUN 20-23, 1994 CL ALBUQUERQUE, NM SP AMER INST PHYS, IEEE, MAGNET SOC, MINERALS MET & MAT SOC, AMER SOC TESTING & MAT, USN, OFF NAVAL RES, AMER CERAM SOC ID IRON-OXIDES AB Superparamagnetic iron oxide particles synthesized in water-in-oil microemulsions have been incorporated into a polymer matrix. The microstructured micellar environment provides a template for polymer synthesis, leading to the formation of interconnected polymer particles with spherical morphologies. The resulting iron oxide-polymer composites reveal superparamagnetic properties and low temperature remanence and susceptibility characteristic of a superparamagnet. The results of temperature and field dependent magnetic characterizations of these composites are described. Ultramicrotomed TEM micrographs show that the iron oxide particles (size < 100 Angstrom) are uniformly distributed in the polymer microspheres. C1 UNIV NEW ORLEANS,DEPT PHYS,NEW ORLEANS,LA 70148. TULANE UNIV,DEPT CHEM ENGN,NEW ORLEANS,LA 70118. TULANE UNIV,DEPT CHEM,NEW ORLEANS,LA 70118. USA,NATICK RES & DEV CTR,NATICK,MA 01760. RP OCONNOR, CJ (reprint author), UNIV NEW ORLEANS,DEPT CHEM,NEW ORLEANS,LA 70148, USA. RI John, Vijay/G-3747-2010 NR 12 TC 7 Z9 7 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD NOV PY 1994 VL 30 IS 6 BP 4954 EP 4956 DI 10.1109/20.334277 PN 1 PG 3 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA PU429 UT WOS:A1994PU42900376 ER PT J AU BALLATO, A GUALTIERI, JG AF BALLATO, A GUALTIERI, JG TI ADVANCES IN HIGH-Q PIEZOELECTRIC RESONATOR MATERIALS AND DEVICES SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article ID ELECTROMECHANICAL PROPERTIES; ALPHA-QUARTZ; CRYSTALS; TRANSDUCERS AB In order to compare piezoelectric materials and devices, an intrinsic parameter, the motional time constant tau1(m) = (omega(m)Q(m))-1 for a particular mode m is employed. The use of tau1(m) follows from the accommodation of acoustic loss in the elastic compliance/stiffness and the establishment of material coefficients that are elements of viscosity matrices. Alternative and fully equivalent definitions of tau1 are given based on the RC time constant derived from the equivalent circuit representation of a crystal resonator, acoustic attenuation, logarithmic decrement, and viscosity or damping. For quartz devices, the variation of tau1 : for any simple thickness mode, for the Y'X shear mode for rotated Y-cuts, and with diameter-thickness ratio for AT-cuts is discussed. Other factors such as mounting loss and loss caused by crystal inhomogeneities (dislocations, defect positions in the resonator, and impurity migration under vibrational stress) are briefly considered with quartz devices as the model. Some new piezoelectric materials/material constants/devices are reviewed and their motional time constants are compared. A physical parameter, composed of acoustic velocity, piezoelectric coupling, and tau1 is identified which aids in understanding the maximum frequency limitations of plate resonators. RP BALLATO, A (reprint author), USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,AMSRL EP,FT MONMOUTH,NJ 07703, USA. NR 63 TC 44 Z9 44 U1 1 U2 9 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD NOV PY 1994 VL 41 IS 6 BP 834 EP 844 DI 10.1109/58.330264 PG 11 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA PP106 UT WOS:A1994PP10600006 PM 18263273 ER PT J AU WEINSTEIN, PD ANDERSON, AO MAGE, RG AF WEINSTEIN, PD ANDERSON, AO MAGE, RG TI RABBIT IGH SEQUENCES IN APPENDIX GERMINAL-CENTERS - VH DIVERSIFICATION BY GENE CONVERSION-LIKE AND HYPERMUTATION MECHANISMS SO IMMUNITY LA English DT Article ID CHAIN VARIABLE-REGION; HUMORAL IMMUNE-SYSTEM; B-CELL DEVELOPMENT; HEAVY-CHAIN; SOMATIC DIVERSIFICATION; ANTIBODY DIVERSITY; LYMPHOID-TISSUES; EMBRYONIC BURSA; PEYERS-PATCHES; VDJ GENES AB Although the rabbit IgH locus contains approximately 100 VH genes, the majority of B cells rearrange VH1. To produce a primary repertoire containing a sufficient number of protective antibodies, rearranged VH1-DH-JH sequences may diversify within rabbit B cells in an organ that functions like a chicken bursa, sheep ileal Peyer's patch, or both. It was suggested many years ago that the rabbit appendix could be a bursal equivalent. To reexamine this possibility, we analyzed rearranged heavy chain variable region sequences in B cells from light and dark zones of appendix germinal centers from B-week old rabbits. Our findings indicate that antibody diversification occurs by gene conversion-like and somatic hypermutation mechanisms in appendix germinal centers of young rabbits. C1 NIAID, IMMUNOL LAB, BETHESDA, MD 20892 USA. RP WEINSTEIN, PD (reprint author), USA, MED RES INST INFECT DIS, DIV APPL RES, FT DETRICK, FREDERICK, MD 21702 USA. NR 67 TC 120 Z9 121 U1 0 U2 3 PU CELL PRESS PI CAMBRIDGE PA 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 SN 1074-7613 J9 IMMUNITY JI Immunity PD NOV PY 1994 VL 1 IS 8 BP 647 EP 659 DI 10.1016/1074-7613(94)90036-1 PG 13 WC Immunology SC Immunology GA PT930 UT WOS:A1994PT93000003 PM 7600292 ER PT J AU KOMISAR, JL SMALLHARRIS, S TSENG, JN AF KOMISAR, JL SMALLHARRIS, S TSENG, JN TI LOCALIZATION OF BINDING-SITES OF STAPHYLOCOCCAL-ENTEROTOXIN-B (SEB), A SUPERANTIGEN, FOR HLA-DR BY INHIBITION WITH SYNTHETIC PEPTIDES OF SEB SO INFECTION AND IMMUNITY LA English DT Article ID CLASS-II MOLECULES; SHOCK SYNDROME TOXIN-1; MURINE T-CELLS; ACCESSORY CELLS; ACTIVATION; EXOTOXINS; TOXICITY; REQUIREMENT; ENGAGEMENT; MONOCYTES AB Staphylococcal enterotoxins are major causes of food poisoning and toxic shock syndrome. Their ability to bind to major histocompatibility complex (MHC) class II molecules has been suggested to be the first step in the mechanism whereby they cause illness. By flow cytometric analysis, the sites of interaction of staphylococcal enterotoxin B (SEB) with HLA-DR molecules were probed in the present study by inhibiting the binding of biotinylated SEB to a human T-cell line (HUT-78) with synthetic peptides of SEB. Five peptides of SEB gave significant inhibition of binding: a peptide containing amino acids 9 to 20 [SEB(9-20)], SEB(30-38), SEB(61-70), SEB(90-114), and SEB(169-181). One peptide, SEB(39-51), enhanced binding, Among the inhibitory peptides, SEB(90-114), a peptide spanning the entire disulfide loop, showed the most efficient inhibition of binding. Peptides SEB(9-20) and SEB(39-51) include amino acid residues that have been identified by previous mutation studies (J.W. Kappler, A. Herman, J. Clements, and P. Marrack, J. Exp. Med. 175:387-396, 1992) as being important in binding to MHC class II. Amino acids lining the alpha 5 groove of SEB have also been postulated to be involved in binding to MHC class LT molecules. However, only two of the residues that line the alpha 5 groove of SEB, His-12 and Tyr-17, are on peptide SEB(9-20) that inhibits binding. These results confirm previous studies that implicated the amino-terminal portion of the molecule in binding to MHC class II molecules and further indicate an important role for residues in other regions, particularly the disulfide loop. RP KOMISAR, JL (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT EXPTL PATHOL,DIV PATHOL,WASHINGTON,DC 20307, USA. NR 52 TC 13 Z9 14 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD NOV PY 1994 VL 62 IS 11 BP 4775 EP 4780 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA PN304 UT WOS:A1994PN30400011 PM 7927754 ER PT J AU SCHELLER, LF WIRTZ, RA AZAD, AF AF SCHELLER, LF WIRTZ, RA AZAD, AF TI SUSCEPTIBILITY OF DIFFERENT STRAINS OF MICE TO HEPATIC INFECTION WITH PLASMODIUM-BERGHEI SO INFECTION AND IMMUNITY LA English DT Article ID FALCIPARUM SPOROZOITES; IRRADIATED SPOROZOITES; YOELII SPOROZOITES; MALARIA; IMMUNIZATION; IMMUNITY; VACCINE AB Despite the low susceptibility of BALB/c mice to hepatic infection by Plasmodium berghei, this animal model is routinely used to investigate the basic biology of the malaria parasite and to test vaccines and the immune response against exoerythrocytic (EE) stages derived from sporozoites. A murine model in which a large number of EE parasites are established would he useful for furthering such investigations. Therefore, we assayed six mouse strains for susceptibility to erythrocytic and hepatic infections. The administration of 50 sporozoites by intravenous inoculation was sufficient to establish erythrocytic infections in five of five C57BL/6 mice compared with 10,000 sporozoites required to infect 100% of BALB/c mice. To assay for hepatic infections, mice received an intravenous inoculum of 10(6) sporozoites, and liver sections for light microscopy and histology were obtained at 29 and 44 h postinoculation. EE parasites were visualized by immunofluorescence, using an antibody to a P. falciparum heat shock protein. The mean number of EE parasites per 100 cm(2) for C57BL/6 and A/J strains was significantly higher than that for BALB/c (2,190 +/- 260, 88 +/- 38, and 6 +/- 2, respectively). The proportion of inoculated sporozoites transforming into liver schizonts was 8.2% in C57BL/6 and <1% in C3H/HeJ, DBA/1, and Swiss CD-1/ICR mice. Nonspecific inflammatory infiltrates around EE parasites were less prevalent in liver sections from C57BL/6 mice than in those from BALB/c mice, which contributed to the decrease in developing EE stages in BALB/c mice. These data indicate that the C57BL/6-P. berghei system is preferable for investigating the biology and immunology of liver stage parasites. C1 UNIV MARYLAND,SCH MED,DEPT MICROBIOL & IMMUNOL,BALTIMORE,MD 21201. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. NR 23 TC 42 Z9 42 U1 1 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD NOV PY 1994 VL 62 IS 11 BP 4844 EP 4847 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA PN304 UT WOS:A1994PN30400021 PM 7927764 ER PT J AU OELSCHLAEGER, TA BARRETT, TJ KOPECKO, DJ AF OELSCHLAEGER, TA BARRETT, TJ KOPECKO, DJ TI SOME STRUCTURES AND PROCESSES OF HUMAN EPITHELIAL-CELLS INVOLVED IN UPTAKE OF ENTEROHEMORRHAGIC ESCHERICHIA-COLI O157/H7 STRAINS SO INFECTION AND IMMUNITY LA English DT Article ID HEMOLYTIC UREMIC SYNDROME; SHIGA-LIKE TOXINS; MAMMALIAN-CELLS; 60-MEGADALTON PLASMID; CHLAMYDIA-PSITTACI; INVASIN PROTEIN; AMINES INHIBIT; O157-H7; RECEPTORS; INFECTION AB Several enterohemorrhagic Escherichia coli (EHEC) strains of serotype O157:H7 isolated from patients with hemorrhagic colitis, ischemic colitis, or hemolytic uremic syndrome were all found to be able to invade certain human epithelial cell lines in vitro. Their ability to gain entry into epithelial cells was compared with those of known invasive Shigella flexneri and Salmonella typhi strains and the noninvasive E. coli strain HB101 in invasion assays utilizing gentamicin to kill extracellular bacteria. All EHEC strains under investigation were efficiently internalized into T24 bladder and HCT-8 ileocecal cells. In striking contrast to shigellae, the same EHEC strains were not taken up into human embryonic intestinal INT407 cells or HEp-2 cells any more than the noninvasive E. coli strain HB101. The mechanism(s) of EHEC internalization was characterized by comparing the invasion efficiencies in the absence and presence of a variety of inhibitors acting on structures and processes of prokaryotic or eukaryotic cells. Also, wild-type, plasmid-containing EHEC strains were compared with their plasmid-cured isogenic derivative strains to determine if plasmid genes affect invasion ability. Plasmid-cured EHEC invaded as well as wild-type EHEC, indicating that invasion ability is chromosomally encoded. Inhibition of bacterial protein synthesis by simultaneous addition of bacteria and chloramphenicol to the monolayer blocked EHEC uptake dramatically, suggesting the presence of an invasion protein(s) with a short half-life. Studies utilizing inhibitors which act on eukaryotic cells demonstrated a strong dependence on microfilaments in the process of uptake of all EHEC strains into both T24 and HCT-8 cells. In general, depolymerization of microtubules as well as inhibition of receptor-mediated endocytosis reduced the efficiency of EHEC invasion of T24 cells, whereas interference with endosome acidification reduced EHEC entry into only HCT-S cells. Taxol-induced stabilization of microtubules did not inhibit internalization into T24 cells or into the HCT-8 cell line. In marked contrast, the ability of S. typhi Ty2 to invade either cell line was inhibited only by depolymerization of microfilaments. In addition to the cell line specificity of EHEC invasion, not all EHEC strains displayed uniform behavior in the presence of inhibitors, suggesting the existence of variant uptake pathways in different strains. Most importantly, previous reports of the inability of EHEC to invade INT407 or HEp-2 cell lines support the currently held belief that EHEC strains are noninvasive. However, our findings demonstrate for the first time the ability of EHEC to invade selected human epithelial cell lines, a process that may be important in EHEC pathogenesis, and define some potential requirements for the invasion mechanism(s). C1 WALTER REED ARMY INST RES, DEPT BACTERIAL DIS, WASHINGTON, DC 20307 USA. CTR DIS CONTROL & PREVENT, DEPT FOODBORNE & ENTER DIS, ATLANTA, GA 30333 USA. RI Oelschlaeger, Tobias/B-5624-2015 NR 44 TC 49 Z9 50 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD NOV PY 1994 VL 62 IS 11 BP 5142 EP 5150 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA PN304 UT WOS:A1994PN30400061 PM 7523304 ER PT J AU ORR, N ARNON, R RUBIN, G COHEN, D BERCOVIER, H LOWELL, GH AF ORR, N ARNON, R RUBIN, G COHEN, D BERCOVIER, H LOWELL, GH TI ENHANCEMENT OF ANTI-SHIGELLA LIPOPOLYSACCHARIDE (LPS) RESPONSE BY ADDITION OF THE CHOLERA-TOXIN B SUBUNIT TO ORAL AND INTRANASAL PROTEOSOME SHIGELLA-FLEXNERI-2A LPS VACCINES SO INFECTION AND IMMUNITY LA English DT Note ID IMMUNE-RESPONSE; IMMUNOGENICITY; IMMUNIZATION AB Addition of the cholera toxin B subunit to oral and intranasal proteosome-Shigella flexneri 2a lipopolysaccharide vaccines improved their immunogenicities. Enhancement of anti-O-Shigella immunoglobulin A levels was most evident in lung lavages following oral immunization and in lung and intestinal fluids when suboptimal doses were used with either immunization route. C1 WEIZMANN INST SCI,DEPT CHEM IMMUNOL,IL-76100 REHOVOT,ISRAEL. HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT CLIN MICROBIOL,IL-91010 JERUSALEM,ISRAEL. WALTER REED ARMY INST RES,DIV PATHOL,WASHINGTON,DC. RP ORR, N (reprint author), ISRAEL DEF FORCES,MED CORPS,IL-02149 MILITARY POST,ISRAEL. NR 15 TC 16 Z9 16 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD NOV PY 1994 VL 62 IS 11 BP 5198 EP 5200 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA PN304 UT WOS:A1994PN30400074 PM 7927807 ER PT J AU HAMBURGER, KE AF HAMBURGER, KE TI THE VIETNAM-WAR, HANDBOOK OF THE LITERATURE AND RESEARCH - OLSON,JS SO INTERNATIONAL HISTORY REVIEW LA English DT Book Review RP HAMBURGER, KE (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ROYAL ROADS MILITARY COLL PI VICTORIA PA FLEET MAIL OFFICE, VICTORIA BC V0S 1B0, CANADA SN 0707-5332 J9 INT HIST REV JI Int. Hist. Rev. PD NOV PY 1994 VL 16 IS 4 BP 851 EP 852 PG 2 WC History SC History GA PV819 UT WOS:A1994PV81900051 ER PT J AU WARD, C CHANG, TM PHILLIPS, TM ACUFF, PR AF WARD, C CHANG, TM PHILLIPS, TM ACUFF, PR TI A COMPARATIVE-STUDY OF SOLAR INTERFERENCE ON THE IRIDIUM AND MSS CONSTELLATIONS SO INTERNATIONAL JOURNAL OF SATELLITE COMMUNICATIONS LA English DT Article DE CONSTELLATION; IRIDIUM; LASER CROSS-LINK; LEO; MSS; SOLAR INTERFERENCE AB Radio frequency cross-links are the preferred communication medium for low earth orbit (LEG) satellite networks today. However, future cross-link designs may be expected to deploy laser crosslinks to increase communication bandwidth. These cross-links are rendered inoperative when incident with high level background radiation sources such as the Sun. The Iridium and Multiple Satellite System (MSS) are two well-researched constellations in the literature and are ideal candidates for the investigation of solar interference on point-to-point constellations. In this paper a comparison of the impact of solar radiation on link availability for these two systems is presented. Evaluation of link availability based on the motions of the bodies in question is computationally infeasible. It is therefore necessary to reduce the state space to a manageable computing basis by reformulating the problem domain and by simulation. In this report the development of an algorithm and a software simulation tool to analyse the two constellations will be presented, and the results of laser cross-link availability will be discussed. The technique introduced here may be generalized to study a variety of different constellations. C1 AUBURN UNIV,DEPT COMP SCI & ENGN,AUBURN,AL 36849. USA,MISSILE COMMAND,CTR RES DEV & ENGN,GUIDANCE & CONTROL DIRECTORATE,REDSTONE ARSENAL,AL 35898. RP WARD, C (reprint author), CUNY HUNTER COLL,DEPT COMP SCI,695 PK AVE,NEW YORK,NY 10021, USA. NR 0 TC 0 Z9 0 U1 3 U2 3 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0737-2884 J9 INT J SATELL COMMUN JI Int. J. Satell. Commun. PD NOV-DEC PY 1994 VL 12 IS 6 BP 525 EP 538 DI 10.1002/sat.4600120603 PG 14 WC Engineering, Aerospace; Telecommunications SC Engineering; Telecommunications GA QF700 UT WOS:A1994QF70000002 ER PT J AU VANCOTT, TC BETHKE, FR KALYANARAMAN, V BURKE, DS REDFIELD, RR BIRX, DL AF VANCOTT, TC BETHKE, FR KALYANARAMAN, V BURKE, DS REDFIELD, RR BIRX, DL TI PREFERENTIAL ANTIBODY RECOGNITION OF STRUCTURALLY DISTINCT HIV-1 GP120 MOLECULES SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE HUMAN IMMUNODEFICIENCY VIRUS; GP120 ENVELOPE; AIDS VACCINES; BIOSPECIFIC INTERACTION ANALYSIS; BIOSENSORS ID IMMUNODEFICIENCY-VIRUS TYPE-1; HUMAN MONOCLONAL-ANTIBODY; BIOSPECIFIC INTERACTION ANALYSIS; SURFACE-PLASMON RESONANCE; CD4 BINDING-SITE; ENVELOPE GLYCOPROTEIN; NEUTRALIZING ANTIBODIES; RECOMBINANT GP160; V3 DOMAIN; ANTIGENIC STRUCTURE AB We have developed an assay, using a biosensor matrix and surface plasmon resonance, that rapidly and reproducibly measures antibody reactivity to human immunodeficiency virus type 1 (HIV-1) gp120 in various structural conformations. In particular, antibodies displaying preferential reactivity to a CD4-binding competent (''native,'' rgp120) or CD4-binding incompetent (''reduced,'' rcmgp120) monomeric gp120 molecule were distinguished. This technique has advantages over conventional enzyme-linked immunosorbent assay (ELISA) methodology in which it is difficult to control the concentration of protein adsorbed to the ELISA wells and a significant disruption of protein structure occurs on adsorption. A population of gp120 molecules that lacked CD4 receptor binding capacity and bound antibodies specific for reduced gp120 was found in several native gp120 preparations. The relative amount of this CD4-binding incompetent population varied among the various preparations studied. This presence of CD4-binding incompetent molecules within various native recombinant gp120 preparations may have implications for HIV-1 envelope vaccine development. By measuring antibody-binding ratios, several monoclonal antibodies were identified, which, although elicited by immunization with various native gp120 preparations, bound specifically to reduced gp120. The ability to screen antibody specificity against HIV-1 envelope proteins with different conformations will assist in determining the quality of antibodies induced by various HIV-1 envelope vaccine candidates. C1 WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD 20850. HENRY M JACKSON FDN,ROCKVILLE,MD. ADV BIOSCI LAB INC,KENSINGTON,MD. RP VANCOTT, TC (reprint author), WALTER REED ARMY INST RES,DEPT RETROVIRAL RES,SUITE 200,13 TAFT CT,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 NR 74 TC 15 Z9 15 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD NOV PY 1994 VL 7 IS 11 BP 1103 EP 1115 PG 13 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA PM299 UT WOS:A1994PM29900001 PM 7523653 ER PT J AU DREA, EJ AF DREA, EJ TI ULTRA IN THE PACIFIC - HOW BREAKING JAPANESE CODES AND CIPHERS AFFECTED NAVAL OPERATIONS AGAINST JAPAN - WINTON,J SO JOURNAL OF ASIAN STUDIES LA English DT Book Review RP DREA, EJ (reprint author), USA,CTR MIL HIST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ASSN ASIAN STUDIES INC PI ANN ARBOR PA UNIV MICH 1 LANE HALL, ANN ARBOR, MI 48109 SN 0021-9118 J9 J ASIAN STUD JI J. Asian Stud. PD NOV PY 1994 VL 53 IS 4 BP 1223 EP 1225 DI 10.2307/2059252 PG 3 WC Area Studies; Asian Studies SC Area Studies; Asian Studies GA QA934 UT WOS:A1994QA93400022 ER PT J AU DAVIS, ST DUCEY, JP FINCHER, CW HOSKING, MP AF DAVIS, ST DUCEY, JP FINCHER, CW HOSKING, MP TI THE ANESTHETIC MANAGEMENT OF A PATIENT WITH CHROMOSOME 10QTER DELETION SYNDROME SO JOURNAL OF CLINICAL ANESTHESIA LA English DT Note DE CHROMOSOME 10; 10QTER DELETION SYNDROME AB Terminal deletions of chromosome 10q are uncommon. The resulting syndrome includes cardiac and facial anomalies, urogenital abnormalities, limb defects, and mental retardation. Most affected infants require surgical correction of these anomalies. Presented are features inherent in the syndrome that will aid the anesthesiologist in the perioperative management of such patients. RP DAVIS, ST (reprint author), BROOKE ARMY MED CTR,DEPT SURG,ANESTHESIA & OPERAT SERV,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU BUTTERWORTH-HEINEMANN PI WOBURN PA 225 WILDWOOD AVE #UNITB PO BOX 4500, WOBURN, MA 01801-2084 SN 0952-8180 J9 J CLIN ANESTH JI J. Clin. Anesth. PD NOV-DEC PY 1994 VL 6 IS 6 BP 512 EP 514 DI 10.1016/0952-8180(94)90095-7 PG 3 WC Anesthesiology SC Anesthesiology GA PX073 UT WOS:A1994PX07300012 PM 7880517 ER PT J AU ABERNATHY, CO ROBERTS, WC AF ABERNATHY, CO ROBERTS, WC TI RISK ASSESSMENT IN THE ENVIRONMENTAL-PROTECTION-AGENCY SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article ID RFD AB Risk assessment is the general process used to determine the potential risk of an adverse health effect occurring from exposure to an agent. It consists of a hazard identification, a dose-response evaluation, an exposure assessment and a risk characterization. At the US Environmental Protection Agency, risk assessments are used to estimate risks from environmental contaminants. Risk management uses the risk characterization along with such variables as economic, social, legal, technical, analytical and political factors to arrive at a regulatory level. The public is informed of regulatory actions prior to and after promulgation of the final rule through the process of risk communication. C1 USA,MATERIAL COMMAND,OFF COMMAND SURG,ALEXANDRIA,VA 22333. RP ABERNATHY, CO (reprint author), US EPA,OFF DRINKING WATER,HUMAN RISK ASSESSMENT BRANCH 4304,401 M ST SW,WASHINGTON,DC 20460, USA. NR 9 TC 7 Z9 7 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD NOV PY 1994 VL 39 IS 2 BP 135 EP 142 DI 10.1016/0304-3894(94)00049-2 PG 8 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA PP992 UT WOS:A1994PP99200002 ER PT J AU BOLUS, RL AF BOLUS, RL TI A SPOT SURVEY OF WILD-RICE IN NORTHERN MINNESOTA SO JOURNAL OF IMAGING SCIENCE AND TECHNOLOGY LA English DT Article AB A survey of the areal extent of wild rice around three lakes in northern Minnesota has been conducted. Wild rice is a desirable natural marsh grass that is sensitive not only to the phosphorus washed from farm, urban, and industrial areas, but also to water level. Both wild birds that migrate along the waterway routes and the Chippewa Indians living there use it as a food staple. The objective of the survey was to produce a geographic information system map from the remotely sensed Satellite Pour l'Observation de la Terra (SPOT) data, showing identification and location of the wild rice on the Chippewa reservation and listing its acreage. The approach used was the technique of supervised spectral classification. The results surprisingly show three distinct and separate spectral populations of wild rice. Although it is unrealistic that different varieties are growing in close proximity, some possible causes for the results are that (1) dissimilar land cover backgrounds are causing different mixed pixel responses, (2) varying crop canopies are causing different detected radiance, and (3) varying water content of the vegetation is causing radiance differences. RP BOLUS, RL (reprint author), USA,CORPS ENGINEERS,CTR REMOTE SENSING & GEOG INFORMAT SYST,72 LYNNE RD,HANOVER,NH 03755, USA. NR 5 TC 0 Z9 0 U1 0 U2 2 PU I S & T - SOC IMAGING SCIENCE TECHNOLOGY PI SPRINGFIELD PA 7003 KILWORTH LANE, SPRINGFIELD, VA 22151 SN 8750-9237 J9 J IMAGING SCI TECHN JI J. Imaging Sci. Technol. PD NOV-DEC PY 1994 VL 38 IS 6 BP 594 EP 597 PG 4 WC Imaging Science & Photographic Technology SC Imaging Science & Photographic Technology GA QN867 UT WOS:A1994QN86700015 ER PT J AU MATHER, B AF MATHER, B TI MATHEMATICS OF CONCRETE SCALING - DISCUSSION SO JOURNAL OF MATERIALS IN CIVIL ENGINEERING LA English DT Discussion RP MATHER, B (reprint author), USA,WATERWAYS EXPT STN,STRUCT LAB,VICKSBURG,MS 39180, USA. NR 2 TC 0 Z9 0 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0899-1561 J9 J MATER CIVIL ENG JI J. Mater. Civ. Eng. PD NOV PY 1994 VL 6 IS 4 BP 614 EP 615 DI 10.1061/(ASCE)0899-1561(1994)6:4(614) PG 2 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA QQ235 UT WOS:A1994QQ23500012 ER PT J AU PICKENS, LG JAWORSKI, J KOVAC, B MILLS, GD AF PICKENS, LG JAWORSKI, J KOVAC, B MILLS, GD TI TRAPS AND BAITS FOR FLIES (DIPTERA) ON PACIFIC ISLANDS SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE TRAPS; BAITS; FLIES AB Studies conducted on Oahu, HI, and on islands of the Kwajalein Atoll, Marshall Islands, demonstrated that adult house flies, Musca domestica L., were attracted to a mixture of cooked rice and chicken and to a commercial bait, whereas adults of Chrysomya megacephala F. and Musca sorbens Wiedemann were attracted to shark fluids or to ripe breadfruit. M. domestica and M. sorbens could be captured in standard inverted-cone traps, whereas C. megacephala could be captured in traps fitted with horizontal entry cones or in cone traps in which the bait was placed inside the cone chamber. M. sorbens and C. megacephala were killed by horizontal electric grids placed over yellow plastic or paper at ground level. M. sorbens was attracted to 15-cm cubes, but not to larger objects. C1 TRIPLER ARMY MED CTR,PREVENT MED SERV,HONOLULU,HI 96859. RP PICKENS, LG (reprint author), USDA ARS,BELTSVILLE AGR RES CTR,INST LIVESTOCK & POULTRY SCI,LIVESTOCK INSECTS LAB,BELTSVILLE,MD 20705, USA. NR 16 TC 5 Z9 6 U1 0 U2 2 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD NOV PY 1994 VL 31 IS 6 BP 828 EP 832 PG 5 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA PP733 UT WOS:A1994PP73300004 PM 7815393 ER PT J AU FATHERAZI, S IZUTSU, KT WELLNER, RB BELTON, CM AF FATHERAZI, S IZUTSU, KT WELLNER, RB BELTON, CM TI HYPOTONICALLY ACTIVATED CHLORIDE CURRENT IN HSG CELLS SO JOURNAL OF MEMBRANE BIOLOGY LA English DT Article DE CHLORIDE CHANNELS; HYPOTONIC STRESS; SALIVARY GLANDS; DUCTAL CELLS; PATCH CLAMP; CYTOSKELETON ID ASCITES TUMOR-CELLS; HUMAN EPITHELIAL-CELLS; VOLUME REGULATION; CL CHANNELS; CONDUCTANCE; K+; CYTOSKELETON; STIMULATION; MEMBRANE; EFFLUX AB Hypotonically induced changes in whole-cell currents and in cell volume were studied in the HSG cloned cell line using the whole-cell, patch clamp and Coulter counter techniques, respectively. Exposures to 10 to 50% hypotonic solutions induced dose-dependent increases in whole-cell conductances when measured using K+ and Cl- containing solutions. An outward current detected at 0 mV, corresponded to a K+ current which was transiently activated, (usually preceding activation of an inward current and had several characteristics in common with a Ca2+-activated K+ current we previously described in these cells. The hypotonically induced inward current had characteristics of a Cl- current. This current was inhibited by NPPB (5-nitro-2-(3-phenyl-propylamino)-benzoate) and SITS (4-acetamido-4'-isothiocyanostilbene), and its reversal potentials corresponded to the Cl- equilibrium potentials at high and low external Cl- concentrations. The induced current inactivated at voltages greater than +80 mV, and the I-V curve was outwardly rectifying. The current was unaffected by addition of BAPTA or removal of GTP from the patch pipette, but was inhibited by removal of ATP or by the presence of extracellular arachidonic acid, quinacrine, nordihydroguairetic acid, and cytochalasin D. Moreover, exposure of HSG cells to hypotonic media caused them to swell and then to undergo a regulatory volume decrease (RVD) response. Neither NPPB, SITS or qui nine acting alone could inhibit RVD, but NPPB and quinine together totally inhibited RVD. These properties, plus the magnitudes of the induced currents, indicate that the hypotonically induced K+ and Cl- currents may underlie the RVD response. Cytochalasin D also blocked the RVD response, indicating that intact cytoskeletal F-actin may be required for activation of the present currents. Hence, our results indicate that hypotonic stress activates K+ and Cl- conductances in these cells, and that the activation pathway for the K+ conductance apparently involves [Ca2+], while the activation pathway for the Cl- conductance does not involve [Ca2+] nor lipoxygenase metabolism, but does require intact cytoskeletal F-actin. C1 USA,MED RES INST INFECT DIS,DIV TOXICOL,FREDERICK,MD 21702. RP FATHERAZI, S (reprint author), UNIV WASHINGTON,SCH DENT,DEPT ORAL BIOL,SB-22,SEATTLE,WA 98195, USA. FU NIDCR NIH HHS [R03 DE10535, R01 DE09812] NR 40 TC 53 Z9 53 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0022-2631 J9 J MEMBRANE BIOL JI J. Membr. Biol. PD NOV PY 1994 VL 142 IS 2 BP 181 EP 193 PG 13 WC Biochemistry & Molecular Biology; Cell Biology; Physiology SC Biochemistry & Molecular Biology; Cell Biology; Physiology GA PR238 UT WOS:A1994PR23800004 PM 7884810 ER PT J AU DEVOID, DE PINEIROCARRERO, VM GOODMAN, Z LATIMER, JS AF DEVOID, DE PINEIROCARRERO, VM GOODMAN, Z LATIMER, JS TI CHRONIC ACTIVE HEPATITIS-B INFECTION IN ROMANIAN ADOPTEES SO JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION LA English DT Note ID VIRUS-INFECTION; CHILDREN C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC. ARMED FORCES INST PATHOL,DEPT HEPAT & GASTROINTESTINAL PATHOL,WASHINGTON,DC. NR 18 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0277-2116 J9 J PEDIATR GASTR NUTR JI J. Pediatr. Gastroenterol. Nutr. PD NOV PY 1994 VL 19 IS 4 BP 431 EP 436 DI 10.1097/00005176-199411000-00012 PG 6 WC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics SC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics GA PV007 UT WOS:A1994PV00700012 PM 7876999 ER PT J AU KLEMME, WR JAMES, P SKINNER, SR AF KLEMME, WR JAMES, P SKINNER, SR TI LATENT ONSET UNILATERAL TOE-WALKING SECONDARY TO HEMANGIOMA OF THE GASTROCNEMIUS SO JOURNAL OF PEDIATRIC ORTHOPAEDICS LA English DT Article DE GASTROCNEMIUS; HEMANGIOMA; TOE-WALKING AB Acquired unilateral pes planus due to hemangioma of the gastrocnemius is an unusual and rarely reported event. In recent years, three children with latent onset unilateral toe-walking due to hemangioma of the proximal gastrocnemius have received treatment at our facility. This report details the usual clinical syndrome and presents postsurgical results. Our experience suggests that in children, a presumptive diagnosis of benign hemangioma of gastrocnemius can be predicated on the basis of history, clinical examination, imaging studies, and laboratory assessment. In contrast to previous reports recommending primary tumor resection, isolated open tendoachilles lengthening can provide acceptable results with minimum morbidity. RP KLEMME, WR (reprint author), TRIPLER ARMY MED CTR,ORTHOPED SERV,HONOLULU,HI 96859, USA. NR 0 TC 10 Z9 11 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0271-6798 J9 J PEDIATR ORTHOPED JI J. Pediatr. Orthop. PD NOV-DEC PY 1994 VL 14 IS 6 BP 773 EP 775 PG 3 WC Orthopedics; Pediatrics SC Orthopedics; Pediatrics GA PM730 UT WOS:A1994PM73000016 PM 7814593 ER PT J AU BERNET, VJ FINGER, DR AF BERNET, VJ FINGER, DR TI GRAVES-DISEASE FOLLOWING SILICONE BREAST IMPLANTATION SO JOURNAL OF RHEUMATOLOGY LA English DT Letter ID SCLERODERMA RP BERNET, VJ (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 10 TC 2 Z9 2 U1 0 U2 0 PU J RHEUMATOL PUBL CO PI TORONTO PA 920 YONGE ST, SUITE 115, TORONTO ON M4W 3C7, CANADA SN 0315-162X J9 J RHEUMATOL JI J. Rheumatol. PD NOV PY 1994 VL 21 IS 11 BP 2169 EP 2169 PG 1 WC Rheumatology SC Rheumatology GA PR235 UT WOS:A1994PR23500040 PM 7869333 ER PT J AU RINNOVATORE, JV LUKENS, KF REINHOLD, J MAHON, W AF RINNOVATORE, JV LUKENS, KF REINHOLD, J MAHON, W TI CHARPY TRANSITION STUDIES OF AN EMBRITTLED AISI-8640 LOWER BAINITIC STEEL SO JOURNAL OF TESTING AND EVALUATION LA English DT Article DE EMBRITTLEMENT; CHARPY IMPACT; TRANSITION TEMPERATURE; 8640 ALLOY STEEL; BAINITE; PHOSPHORUS; ARSENIC AB A study was performed of the effects of phosphorus and arsenic as embrittling agents on the Charpy impact behavior of resulfurized AISI 8640 steel. The steel was heat-treated to several bainitic and one martensitic condition with a wide range of strength levels. Charpy transition temperature curves were developed for each condition. SEM fractography was used to analyze the fracture behavior of the various heat-treated structures. The results show that AISI 8640 steel with high phosphorus and high arsenic was embrittled in the low-strength bainitic condition as well as in the high-strength martensitic condition. Embrittlement was evidenced by low Charpy impact energies, increased transition temperatures, and an intergranular fracture mode. RP RINNOVATORE, JV (reprint author), USA,ARMAMENT RES,CTR DEV & ENGN,PICATINNY ARSENAL,NJ 07806, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0090-3973 J9 J TEST EVAL JI J. Test. Eval. PD NOV PY 1994 VL 22 IS 6 BP 517 EP 521 PG 5 WC Materials Science, Characterization & Testing SC Materials Science GA PQ501 UT WOS:A1994PQ50100003 ER PT J AU SMITH, KJ SKELTON, HG YEAGER, J LEDSKY, R MCCARTHY, W BAXTER, D WAGNER, KF AF SMITH, KJ SKELTON, HG YEAGER, J LEDSKY, R MCCARTHY, W BAXTER, D WAGNER, KF TI CUTANEOUS FINDINGS IN HIV-1-POSITIVE PATIENTS - A 42-MONTH PROSPECTIVE-STUDY SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; TUMOR-NECROSIS-FACTOR; FLOW CYTOMETRIC ANALYSIS; HIV-INFECTION; HOMOSEXUAL MEN; T-CELLS; ANTICARDIOLIPIN ANTIBODIES; HIV-1-INFECTED PATIENTS; MOSQUITO BITES; DISEASE AB Background: Cutaneous disease is common in patients infected with HIV-1. Objective: The aim of our study was to identify cutaneous markers associated with HIV-1 infection and disease progression as measured by Walter Reed (WR) stage. Methods: For 42 months we have observed 912 HIV-1-positive patients in all WR stages. All patients had an extensive past and present medical history taken as well as a complete physical examination, periodic visits, and appropriate diagnostic procedures. Results: Increasing dryness of the skin and seborrheic dermatitis are early findings in a large percentage of patients in WR stage 1; the occurrence and severity of both conditions increase with disease progression. Tinea infections, condylomata acuminata, and verrucae are seen early, but with disease progression, although there is no dear increase in occurrence, these infections become more diffuse and resistant to treatment. Flares in acne vulgaris and folliculitis show a peak occurrence in early and mid-stage disease with a decreased occurrence in late-stage disease. Herpes simplex infections, oral candidiasis, molluscum contagiosum, Staphylococcus aureus infections, and oral hairy leukoplakia show a marked increase in occurrence with advanced disease. Conditions that have a statistically significant association with disease progression as measured by a change in stage include drug eruptions, seborrheic dermatitis, oral candidiasis, oral hairy leukoplakia, molluscum contagiosum, herpes tester, and hyperpigmentation (nail, oral, skin). Conclusion: The most frequent and persistent cutaneous disorders were asteatosis (with or without asteatotic eczema) and seborrheic dermatitis. Conditions that were associated with a change in WR stage include drug eruptions, seborrheic dermatitis, oral candidiasis, oral hairy leukoplakia, molluscum contagiosum, herpes tester, and hyperpigmentation. In addition to Kaposi's sarcoma, patients with HIV-1 disease have an increased potential. for the de development of both cutaneous epithelial and probably melanocytic malignancies. Epithelial tumors were seen in patients in all stages of disease. C1 ARMED FORCES INST RES,WASHINGTON,DC. HENRY M JACKSON FDN,WASHINGTON,DC. USN,NATL HOSP,DEPT DERMATOL,BETHESDA,MD. RP SMITH, KJ (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307, USA. FU NIAMS NIH HHS [Y01AR00014, Y01AR90008] NR 81 TC 107 Z9 114 U1 0 U2 5 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD NOV PY 1994 VL 31 IS 5 BP 746 EP 754 PN 1 PG 9 WC Dermatology SC Dermatology GA PN838 UT WOS:A1994PN83800008 PM 7929920 ER PT J AU CALDWELL, JB YANCEY, KB ENGLER, RJM JAMES, WD AF CALDWELL, JB YANCEY, KB ENGLER, RJM JAMES, WD TI EPIDERMOLYSIS-BULLOSA ACQUISITA - EFFICACY OF HIGH-DOSE INTRAVENOUS IMMUNOGLOBULINS SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Letter ID GLOBULIN C1 NATL INST HLTH,DERMATOL BRANCH,BETHESDA,MD. WALTER REED ARMY MED CTR,DEPT ALLERGY & IMMUNOL,WASHINGTON,DC. RP CALDWELL, JB (reprint author), WALTER REED ARMY MED CTR,DEPT DERMATOL,WASHINGTON,DC 20307, USA. NR 3 TC 34 Z9 34 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD NOV PY 1994 VL 31 IS 5 BP 827 EP 828 PN 1 PG 2 WC Dermatology SC Dermatology GA PN838 UT WOS:A1994PN83800035 PM 7929940 ER PT J AU SPERLING, LC AF SPERLING, LC TI BIOLOGY OF ANDROGENIC DISORDERS IN WOMEN - REPLY SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Letter RP SPERLING, LC (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD NOV PY 1994 VL 31 IS 5 BP 827 EP 827 PN 1 PG 1 WC Dermatology SC Dermatology GA PN838 UT WOS:A1994PN83800034 ER PT J AU CARTER, AJ LAIRD, JR FARB, A KUFS, W WORTHAM, DC VIRMANI, R AF CARTER, AJ LAIRD, JR FARB, A KUFS, W WORTHAM, DC VIRMANI, R TI MORPHOLOGIC CHARACTERISTICS OF LESION FORMATION AND TIME-COURSE OF SMOOTH-MUSCLE CELL-PROLIFERATION IN A PORCINE PROLIFERATIVE RESTENOSIS MODEL SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Article ID LUMINAL CORONARY ANGIOPLASTY; ANGIOGRAPHIC FOLLOW-UP; BALLOON ANGIOPLASTY; INTIMAL PROLIFERATION; STENT IMPLANTATION; INJURY; ARTERIES; KINETICS; PLAQUE AB Objectives. This study was performed to define the evolution of lesion morphology and its relation to thrombus formation and smooth muscle cell proliferation after experimental coronary stent placement. Background. Restenosis after percutaneous revascularization may develop because of thrombus accumulation and smooth muscle cell proliferation. In animal models of restenosis, thrombus may assume a significant role in neointimal formation by providing an absorbable matrix into which smooth muscle cells proliferate. Methods. Twenty eight oversized stents were placed in the coronary arteries of 23 juvenile domestic pigs. The histologic degree of vessel injury, lesion morphometry and smooth muscle cell proliferation measured by immunolocalization with a mono clonal antibody to proliferating cell nuclear antigen (PCNA) were assessed. at 24 h and 7, 14 and 28 days after stent placement. Results. The area of thrombus was minimal at 24 h ([mean +/- SE] 044 +/- 0.12 mm(2)). Neointimal area at 7 days (0.72 +/- 0.20 mm(2)) was similar to the area of thrombus, followed by a significant increase at 14 days (3.15 +/- 0.39 mm(2)) and 28 days (3.30 +/- 0.28 mm(2)) (p < 0.0036, 24 h and 7 days vs. 14 and 28 days). At 14 and 28 days, neointimal thickness correlated with the histologic degree of vessel injury (p < 0.003). In arteries with severe injury, the increase in neointimal thickness is accounted for by replacement of the damaged media. The smooth muscle cell proliferation index was 18.6 +/- 3.5% at 7 days compared with 9.6 +/- 13% by 14 days (p = 0.0247) and declined to 1.1 +/- 0.97% by 28 days (p < 0.008, 7 and 14 days vs. 28 days). Conclusions. Early thrombus formation is minimal, and thrombus accounts for a small portion of subsequent neointimal formation. Smooth muscle cell proliferation and matrix formation are the major factors relating to neointimal formation in this proliferative model of restenosis. The evolution of neointimal formation after coronary stenting shows maximal smooth muscle cell proliferation at 7 days, with a decline to low levels by 28 days. Therefore, these data may be useful for developing effective therapies for restenosis. C1 ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. RP CARTER, AJ (reprint author), WALTER REED ARMY MED CTR,SERV CARDIOL,WASHINGTON,DC, USA. NR 29 TC 183 Z9 195 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD NOV 1 PY 1994 VL 24 IS 5 BP 1398 EP 1405 PG 8 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA PN650 UT WOS:A1994PN65000031 PM 7930266 ER PT J AU BACH, DE WAITE, PD ADAMS, RC AF BACH, DE WAITE, PD ADAMS, RC TI AUTOLOGOUS TMJ DISK REPLACEMENT SO JOURNAL OF THE AMERICAN DENTAL ASSOCIATION LA English DT Article ID IMPLANTATION FOLLOWING DISCECTOMY; PRIMATE TEMPOROMANDIBULAR-JOINT; SURGICAL-TREATMENT; LONG-TERM; MENISCECTOMY; GRAFTS AB Several techniques have been advocated for replacement of displaced or diseased temporomandibular joint disks. Techniques are reviewed and the author's experience in managing this complex problem is presented. C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. NR 38 TC 4 Z9 4 U1 0 U2 0 PU AMER DENTAL ASSN PI CHICAGO PA 211 E CHICAGO AVE, CHICAGO, IL 60611 SN 0002-8177 J9 J AM DENT ASSOC JI J. Am. Dent. Assoc. PD NOV PY 1994 VL 125 IS 11 BP 1504 EP & PG 0 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA PQ507 UT WOS:A1994PQ50700017 PM 7963102 ER PT J AU LOUBE, DI LOUBE, AA MITLER, MM AF LOUBE, DI LOUBE, AA MITLER, MM TI WEIGHT-LOSS FOR OBSTRUCTIVE SLEEP-APNEA - THE OPTIMAL THERAPY FOR OBESE PATIENTS SO JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION LA English DT Article ID MORBID-OBESITY AB Obstructive sleep apnea (OSA) is a common disorder in which upper-airway obstruction during sleep results in cessation of breathing. OSA is associated with increased morbidity and mortality and impaired daytime functioning. Upper-body obesity is a risk factor for OSA, and it is well documented that weight loss has a notable ameliorative impact on the occurrence of OSA. Nasal continuous positive airway pressure (nCPAP) during sleep is the primary treatment for OSA, and is usually effective in relieving upper-airway obstruction. However, compliance with prolonged nCPAP use has been proven problematic. Upper-airway surgeries may be efficacious for the treatment of OSA in carefully selected patients, but often are not successful for obese patients with OSA. The concomitant use of nCPAP and behavioral weight loss therapy in obese patients with OSA may result in enhanced weight loss. In moderately obese patients, modest weight reduction may alleviate the need for long-term nCPAP therapy or upper-airway surgery. Severely obese patients usually require more substantial weight loss and may be candidates for behavioral therapy in combination with gastric surgery. The role of the dietitian in the treatment of OSA cannot be overemphasized and warrants further development and study. C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. UNIV CALIF SAN DIEGO,SAN DIEGO,CA 92103. SCRIPPS CLIN & RES FDN,CTR SLEEP DISORDERS,LA JOLLA,CA 92037. NR 58 TC 38 Z9 39 U1 0 U2 2 PU AMER DIETETIC ASSN PI CHICAGO PA 216 W JACKSON BLVD #800, CHICAGO, IL 60606-6995 SN 0002-8223 J9 J AM DIET ASSOC JI J. Am. Diet. Assoc. PD NOV PY 1994 VL 94 IS 11 BP 1291 EP 1295 DI 10.1016/0002-8223(94)92462-7 PG 5 WC Nutrition & Dietetics SC Nutrition & Dietetics GA PQ974 UT WOS:A1994PQ97400017 PM 7963174 ER PT J AU ADAMS, SO MALLER, O CARDELLO, AV AF ADAMS, SO MALLER, O CARDELLO, AV TI SODIUM AID POTASSIUM MIXTURES CAN REDUCE SODIUM-LEVELS SO JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION LA English DT Article ID SALT; SUBSTITUTE; CHLORIDE C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. RP ADAMS, SO (reprint author), GEOCENTERS INC,190 N MAIN ST,NATICK,MA 01760, USA. NR 18 TC 5 Z9 5 U1 0 U2 1 PU AMER DIETETIC ASSN PI CHICAGO PA 216 W JACKSON BLVD #800, CHICAGO, IL 60606-6995 SN 0002-8223 J9 J AM DIET ASSOC JI J. Am. Diet. Assoc. PD NOV PY 1994 VL 94 IS 11 BP 1313 EP 1315 DI 10.1016/0002-8223(94)92469-4 PG 3 WC Nutrition & Dietetics SC Nutrition & Dietetics GA PQ974 UT WOS:A1994PQ97400023 PM 7963179 ER PT J AU KOTULAK, JC MORSE, SE AF KOTULAK, JC MORSE, SE TI RELATIONSHIP AMONG ACCOMMODATION, FOCUS, AND RESOLUTION WITH OPTICAL-INSTRUMENTS (VOL 11, PG 71, 1994) SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Correction, Addition RP KOTULAK, JC (reprint author), USA,AEROMED RES LAB,VISUAL SCI BRANCH,POB 620577,FT RUCKER,AL 36362, USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0740-3232 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD NOV PY 1994 VL 11 IS 11 BP 2919 EP 2919 DI 10.1364/JOSAA.11.002919 PG 1 WC Optics SC Optics GA PN300 UT WOS:A1994PN30000020 ER PT J AU MOUL, JW FERNANDEZ, EB BRYAN, MG STEUART, P HO, CK MCLEOD, DG AF MOUL, JW FERNANDEZ, EB BRYAN, MG STEUART, P HO, CK MCLEOD, DG TI THYMIC HYPERPLASIA IN NEWLY-DIAGNOSED TESTICULAR GERM-CELL TUMORS SO JOURNAL OF UROLOGY LA English DT Article DE TESTICULAR NEOPLASMS; THYMUS; GERM CELLS; HYPERPLASIA ID HODGKINS-DISEASE; REBOUND PHENOMENON; CHEMOTHERAPY; ENLARGEMENT; CANCER; ASSOCIATION AB Thymic hyperplasia has been reported as a rebound phenomenon in children and young people, most commonly following chemotherapy for cancer. Although thymic hyperplasia has been documented in testis cancer patients after chemotherapy, to our knowledge it has not previously been reported in newly diagnosed cases before systemic therapy. A retrospective review of 362 testicular germ cell tumor patients treated at a single tertiary care center between January 1, 1980 and August 1, 1993 was performed, with special review of 221 who underwent computerized tomography staging of the chest. Thymic hyperplasia was detected in 4 of the 221 patients (1.8%) including 3 of 100 (3.0%) with seminoma and 1 of 121 (0.8%) with nonseminoma. All 4 patients had low stage (I or IIa) disease with a delay in diagnosis (5 to 24 weeks) and thymic hyperplasia was discovered at staging evaluation 18 to 37 days after orchiectomy but before other cancer therapy was administered. Of the 4 patients 2 underwent thymectomy, revealing histological thymic rebound hyperplasia. All 4 patients had no evidence of recurrence at 1 to 54 months after treatment. In addition to the well known post-chemotherapy phenomenon, thymic hyperplasia may also occur in nonsystemically treated, newly diagnosed testicular cancer patients. An anterior mediastinal mass in an otherwise low stage newly diagnosed testicular cancer patient may represent thymic hyperplasia and not necessarily metastatic disease. C1 WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT SURG,UROL SERV,WASHINGTON,DC 20307. RP MOUL, JW (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 26 TC 6 Z9 6 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD NOV PY 1994 VL 152 IS 5 BP 1480 EP 1483 PN 1 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA PL685 UT WOS:A1994PL68500037 PM 7933189 ER PT J AU AUSTENFELD, MS THOMPSON, IM MIDDLETON, RG AF AUSTENFELD, MS THOMPSON, IM MIDDLETON, RG TI METAANALYSIS OF THE LITERATURE GUIDELINE DEVELOPMENT FOR PROSTATE-CANCER TREATMENT SO JOURNAL OF UROLOGY LA English DT Article; Proceedings Paper CT Conference on Detection and Treatment of Early Stage Prostate Cancer CY DEC 03-05, 1993 CL CRYSTAL CITY, VA SP AMER UROL ASSOC, AMER CANC SOC, NCI, AMER COLL SURGEONS COMMISS CANC DE PROSTATIC NEOPLASMS; PRACTICE MANAGEMENT, MEDICAL; METAANALYSIS; OUTCOME ASSESSMENT (HEALTH CARE) AB Medical interventions are identified to be in need of practice guidelines based on several criteria, including uncertainty of therapeutic benefit, economic impact, variation in practice patterns and lack of objective data for new developments. Treatment of localized adenocarcinoma of the prostate meets these criteria and has been identified as an issue in need of practice guideline development. The American Urological Association began working toward establishing prostate cancer treatment guidelines in 1989. An explicit method based on collection of scientific data was adopted, which requires complete review of the literature and analysis of the evidence collected. An update on the progress toward this data analysis and guideline document is presented. C1 BROOKE ARMY MED CTR,DEPT SURG,UROL SERV,FT SAM HOUSTON,TX 78234. UNIV UTAH,MED CTR,DIV UROL,SALT LAKE CITY,UT 84112. RP AUSTENFELD, MS (reprint author), UNIV KANSAS,MED CTR,UROL SECT,KANSAS CITY,KS 66103, USA. NR 8 TC 19 Z9 19 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD NOV PY 1994 VL 152 IS 5 BP 1866 EP 1869 PN 2 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA PL686 UT WOS:A1994PL68600047 PM 7933243 ER PT J AU HANDLEY, MR AUSTENFELD, MS SCARDINO, PT COCKETT, ATK MCCONNELL, JD SIMPSON, KN CHODAK, GW MCCULLOUGH, DL LITTRUP, PJ BAGSHAW, MA FEIGHTNER, JW OESTERLING, JE CATALONA, WJ AF HANDLEY, MR AUSTENFELD, MS SCARDINO, PT COCKETT, ATK MCCONNELL, JD SIMPSON, KN CHODAK, GW MCCULLOUGH, DL LITTRUP, PJ BAGSHAW, MA FEIGHTNER, JW OESTERLING, JE CATALONA, WJ TI DISCUSSION SO JOURNAL OF UROLOGY LA English DT Discussion ID PROSTATE-CANCER C1 UNIV KANSAS, MED CTR, UROL SECT, KANSAS CITY, KS 66103 USA. BROOKE ARMY MED CTR, DEPT SURG, UROL SERV, FT SAM HOUSTON, TX 78234 USA. UNIV UTAH, MED CTR, DIV UROL, SALT LAKE CITY, UT USA. BAYLOR COLL MED, MATSUNAGA CONTE PROSTATE CANC RES CTR, SCOTT DEPT UROL, HOUSTON, TX USA. BAYLOR COLL MED, DEPT PATHOL, HOUSTON, TX 77030 USA. BAYLOR COLL MED, DEPT MED, HOUSTON, TX 77030 USA. METHODIST HOSP, HOUSTON, TX 77030 USA. STANFORD UNIV, MED CTR, DEPT UROL, STANFORD, CA 94305 USA. UNIV N CAROLINA, SCH PUBL HLTH, DEPT HLTH POLICY & ADM, CHAPEL HILL, NC USA. UNIV CHICAGO, PRITZKER SCH MED, CHICAGO, IL 60637 USA. WEISS MEM HOSP, CTR PROSTATE & UROL, CHICAGO, IL USA. WAYNE STATE UNIV, HARPER HOSP, DEPT RADIOL, DETROIT, MI 48201 USA. MCMASTER UNIV, DEPT FAMILY MED, HAMILTON L8S 4L8, ON, CANADA. MAYO CLIN & MAYO FDN, DEPT UROL, ROCHESTER, MN 55905 USA. MAYO CLIN & MAYO FDN, BIOSTAT SECT, ROCHESTER, MN 55905 USA. KAMAN SCI CORP, COLORADO SPRINGS, CO USA. WASHINGTON UNIV, SCH MED, DIV UROL SURG, ST LOUIS, MO 63110 USA. RP HANDLEY, MR (reprint author), GRP HLTH COOPERAT PUGET SOUND, DEPT MED EDUC, SEATTLE, WA 98121 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 EI 1527-3792 J9 J UROLOGY JI J. Urol. PD NOV PY 1994 VL 152 IS 5 BP 1870 EP 1872 PN 2 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA PL686 UT WOS:A1994PL68600048 ER PT J AU SCARDINO, PT LITWIN, MS ANDRIOLE, GL MILES, BJ MENON, M AUSTENFELD, MS CATALONA, WJ GROSSMAN, HB BECK, JR WILT, TJ GOHAGAN, JK OLSSON, CA AF SCARDINO, PT LITWIN, MS ANDRIOLE, GL MILES, BJ MENON, M AUSTENFELD, MS CATALONA, WJ GROSSMAN, HB BECK, JR WILT, TJ GOHAGAN, JK OLSSON, CA TI DISCUSSION SO JOURNAL OF UROLOGY LA English DT Discussion ID PROSTATE-CANCER C1 UNIV CALIF LOS ANGELES, DEPT SURG, DIV UROL, LOS ANGELES, CA 90024 USA. WASHINGTON UNIV, SCH MED, DIV UROL SURG, ST LOUIS, MO 63110 USA. WASHINGTON UNIV, SCH MED, DIV LAB MED, ST LOUIS, MO 63110 USA. BAYLOR COLL MED, DEPT PATHOL, INFORMAT TECHNOL PROGRAM, HOUSTON, TX 77030 USA. UNIV KANSAS, MED CTR, UROL SECT, KANSAS CITY, KS 66103 USA. BROOKE ARMY MED CTR, DEPT SURG, UROL SERV, FT SAM HOUSTON, TX 78234 USA. UNIV UTAH, MED CTR, DIV UROL, SALT LAKE CITY, UT USA. WASHINGTON UNIV, SCH MED, DIV UROL SURG, ST LOUIS, MO 63110 USA. VET ADM MED CTR, DEPT MED, GEN INTERNAL MED SECT, MINNEAPOLIS, MN USA. UNIV MINNESOTA, MINNEAPOLIS, MN 55455 USA. VET ADM MED CTR, DEPT UROL, SEATTLE, WA 98108 USA. UNIV WASHINGTON, SEATTLE, WA 98195 USA. NCI, DIV CANC PREVENT & CONTROL, BETHESDA, MD 20892 USA. COLUMBIA UNIV, COLL PHYS & SURG,COLUMBIA PRESBYTERIAN MED CTR, SQUIER UROL CLIN,DEPT UROL, NEW YORK, NY 10032 USA. RP SCARDINO, PT (reprint author), BAYLOR COLL MED, DEPT UROL, INFORMAT TECHNOL PROGRAM, HOUSTON, TX 77030 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 EI 1527-3792 J9 J UROLOGY JI J. Urol. PD NOV PY 1994 VL 152 IS 5 BP 1900 EP 1902 PN 2 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA PL686 UT WOS:A1994PL68600054 ER PT J AU KO, KK PANG, SW BROCK, T COLE, MW CASAS, LM AF KO, KK PANG, SW BROCK, T COLE, MW CASAS, LM TI EVALUATION OF SURFACE DAMAGE ON GAAS ETCHED WITH AN ELECTRON-CYCLOTRON-RESONANCE SOURCE SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article; Proceedings Paper CT 38th International Symposium on Electron, Ion and Photon Beams CY MAY 31-JUN 03, 1994 CL NEW ORLEANS, LA SP AMER VACUUM SOC, IEEE, ELECTRON DEVICE SOC, OPT SOC AMER ID ION; SEMICONDUCTORS C1 USA,RES LAB,FT MONMOUTH,NJ 07703. RP KO, KK (reprint author), UNIV MICHIGAN,DEPT ELECT ENGN & COMP SCI,ANN ARBOR,MI 48109, USA. RI Pang, Stella/A-7770-2012 OI Pang, Stella/0000-0002-4330-0877 NR 14 TC 21 Z9 21 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0734-211X J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD NOV-DEC PY 1994 VL 12 IS 6 BP 3382 EP 3387 DI 10.1116/1.587517 PG 6 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA PY133 UT WOS:A1994PY13300056 ER PT J AU BALOCKI, JB BURGES, SJ AF BALOCKI, JB BURGES, SJ TI RELATIONSHIPS BETWEEN N-DAY FLOOD VOLUMES FOR INFREQUENT LARGE FLOODS SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT-ASCE LA English DT Article AB Design floods of specified frequency are used to consider relevant hydrologic and economic factors int he evaluation of operation, or changes in operation, of flood-damage mitigation facilities. The design flood hydrograph is constructed using flood volumes, often extrapolated beyond observed records, from flood-volume-duration-frequency curves. We examined the foundation of this approach using flood flow data from seven Pacific Northwest river catchments. Nested occurrence of large-return-period flood volumes (i.e., 1-day and n-day flood volumes occur concurrently), for flood durations important to decision making, held true for all seven basins. Coincidence of floods occurs when the 1-day and n-day flood volumes have the same return period. Flood volume-frequency and duration for the largest two or three flood volumes is strongly related (coincident) in three catchments and moderately related in three others. No apparent relationship was observed in the seventh. No link is apparent for any of the seven catchments between catchment physical and climatological features and flood-volume concurrence or coincidence of frequency. These results indicate the flood-hydrograph-frequency record for each catchment should be evaluated prior to using assumed nested volume relationships to derive a design flood hydrograph having a given exceedance frequency. A general method for constructing design flood hydrographs for low exceedance probabilities (high return periods) is given. C1 UNIV WASHINGTON,DEPT CIVIL ENGN,SEATTLE,WA 98195. RP BALOCKI, JB (reprint author), USA,CORPS ENGRS,WALLA WALLA,WA 99362, USA. NR 26 TC 8 Z9 8 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9496 J9 J WATER RES PL-ASCE JI J. Water Resour. Plan. Manage.-ASCE PD NOV-DEC PY 1994 VL 120 IS 6 BP 794 EP 818 DI 10.1061/(ASCE)0733-9496(1994)120:6(794) PG 25 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA PM503 UT WOS:A1994PM50300004 ER PT J AU WALTON, TL AF WALTON, TL TI SHORELINE SOLUTION FOR TAPERED BEACH FILL SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Note AB An analytical solution for the evolution of the planform for a beach fill with tapered ends is presented, and solution charts are given for two cases of taper-section length to straight fill-section length. An analytical solution for the proportion of fill remaining after a given time is also presented as a function of a dimensionless time constant. RP WALTON, TL (reprint author), USA CORPS ENGINEERS,COAST ENGN RES CTR,WTRWY EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 6 TC 13 Z9 13 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD NOV-DEC PY 1994 VL 120 IS 6 BP 651 EP 655 DI 10.1061/(ASCE)0733-950X(1994)120:6(651) PG 5 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA PM488 UT WOS:A1994PM48800011 ER PT J AU BARTH, J AF BARTH, J TI THE BUFFETT,WARREN WAY - INVESTMENT STRATEGIES OF THE WORLDS GREATEST INVESTOR - HAGSTROM,RG SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), USA,MIL ACAD LIB,W POINT,NY, USA. NR 1 TC 0 Z9 0 U1 0 U2 2 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD NOV 1 PY 1994 VL 119 IS 18 BP 90 EP 90 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA PP320 UT WOS:A1994PP32000146 ER PT J AU PIERSON, LL GERHARDT, KJ ABRAMS, RM GRIFFITHS, SK PETERS, AJM AF PIERSON, LL GERHARDT, KJ ABRAMS, RM GRIFFITHS, SK PETERS, AJM TI EFFECT OF IMPULSE NOISE ON THE AUDITORY BRAIN-STEM RESPONSE OF THE FETAL SHEEP AND THE ADULT EWE - CASE-STUDY SO MILITARY MEDICINE LA English DT Article AB Auditory brainstem responses (ABR) were obtained from a sheep fetus in utero and from a nonpregnant ewe before and after a noise exposure generated by 10 105-mm howitzer impulses (160-166 dB peak pressure). Fetal ABR thresholds shifted by less than 15 dB, whereas the adult thresholds shifted more than 50 dB, Comparison of exposed and nonexposed fetal cytocochleograms revealed minimal sensory cell loss in two age-matched animals, Although fetal ABR threshold shifts were noted in this study, the magnitude of shift was modest when compared to the significant elevation of the adult ABR thresholds. RP PIERSON, LL (reprint author), USA,AMSRL SD HR,ATTN,HUMAN RES & ENGN DIRECTORATE,ABERDEEN PROVING GROUND,MD 21005, USA. FU NICHD NIH HHS [HD 20084] NR 0 TC 3 Z9 3 U1 1 U2 2 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 1994 VL 159 IS 11 BP 676 EP 680 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA QD553 UT WOS:A1994QD55300005 PM 7885594 ER PT J AU KENNEDY, TE AF KENNEDY, TE TI THE EVOLUTION OF NURSING RESEARCH IN THE ARMY-NURSE-CORPS SO MILITARY MEDICINE LA English DT Article AB The growth of nursing research has been richly nurtured in the military nursing community. Army nurses have been at the forefront of the growth of the discipline both within the military community and at civilian institutions after their departure from active duty, This paper describes the development of the nursing research program by the Army Nurse Corps (ANC) within the Army Medical Department (AMEDD) from its earliest stages through the present, it discusses the organizational structure of nursing research within the ANC and the leadership innovations being implemented to make nursing research responsive to the needs of the AMEDD into the next century, RP KENNEDY, TE (reprint author), USA,NURSE CORPS,OFF CHIEF,DASG CN,5111 LEESBURG PIKE,FALLS CHURCH,VA 22041, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 1994 VL 159 IS 11 BP 680 EP 683 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA QD553 UT WOS:A1994QD55300006 PM 7885595 ER PT J AU MANGELSDORFF, AD AF MANGELSDORFF, AD TI PATIENT ATTITUDES AND UTILIZATION PATTERNS IN ARMY MEDICAL-TREATMENT FACILITIES SO MILITARY MEDICINE LA English DT Article AB In Section 733 of the National Defense Authorization Act for Fiscal Years 1992 and 1993, Congress directed the Department of Defense to study the military medical care system. When the Congressionally directed study findings become available, baseline data will be needed for comparison. From 1989 to 1992, patient satisfaction surveys were conducted of eligible beneficiaries who might seek health care in Army military medical treatment facilities (MMTFs). Regression models were developed to predict overall quality of care, Most of the beneficiaries are generally satisfied with the Army health care system. However, care provided by CHAMPUS, private, or other sources is rated more satisfying than that in MMTFs. Retired personnel were most satisfied, whereas active duty dependents were the least satisfied group. RP MANGELSDORFF, AD (reprint author), USA,MED DEPT CTR & SCH,CTR HEALTHCARE EDUC & STUDIES,MCCS HRA,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 1994 VL 159 IS 11 BP 686 EP 690 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA QD553 UT WOS:A1994QD55300008 PM 7885597 ER PT J AU LAMIELL, JM AF LAMIELL, JM TI RESEARCH FOR GRADUATE MEDICAL-EDUCATION SO MILITARY MEDICINE LA English DT Article AB Several important questions are addressed herein, What is graduate medical education (GME), and what is research? What is the history of the association between GME and research? Why is research required for GME? What research is required for GME? How will health care reform affect GME and biomedical research? How much research is done in the United States? How can the value of research be assessed? What can we expect for the future with respect to GME and research? RP LAMIELL, JM (reprint author), BROOKE ARMY MED CTR,DEPT CLIN INVEST,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 1994 VL 159 IS 11 BP 698 EP 704 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA QD553 UT WOS:A1994QD55300011 PM 7885600 ER PT J AU WITTICH, AC OLSON, HL ELG, SA AF WITTICH, AC OLSON, HL ELG, SA TI TUBERCULOUS PERITONITIS IN A YOUNG FEMALE DIAGNOSED USING MINI-LAPAROTOMY - A CASE-REPORT SO MILITARY MEDICINE LA English DT Note AB An 18-year-old female Pacific Islander with abdominal pain, ascites, and fever was transferred to our hospital with suspected ovarian malignancy, These nonspecific clinical features of tuberculous peritonitis in a female frequently contribute to misdiagnosis, Preoperative findings included negative sputums, negative purified protein derivative, and no acid-fast bacilli (AFB) found in peritoneal fluid or fine needle biopsy of the omentum, Tuberculous peritonitis was diagnosed after omental biopsy obtained at mini-laparotomy showed granulomatous inflammation and positive isolation of AFB. RP WITTICH, AC (reprint author), TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,HONOLULU,HI 96859, USA. NR 0 TC 4 Z9 4 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 1994 VL 159 IS 11 BP 715 EP 717 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA QD553 UT WOS:A1994QD55300015 PM 7885604 ER PT J AU BERIGAN, TR ADAMS, DW AF BERIGAN, TR ADAMS, DW TI THERAPEUTIC LITHIUM-RELATED CARDIAC CONDUCTION DISTURBANCE IN A PREVIOUSLY HEALTHY PATIENT - A CASE-REPORT SO MILITARY MEDICINE LA English DT Note AB A case is presented in which a 37-year-old female with bipolar affective disorder, no known cardiac problem, and treated successfully with lithium for over 1 year developed significant sinoatrial node block, which resolved in less than 24 hours upon discontinuation of lithium, RP BERIGAN, TR (reprint author), TRIPLER ARMY MED CTR,DEPT PSYCHIAT,TRIPLER AMC,HI 96859, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 1994 VL 159 IS 11 BP 717 EP 717 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA QD553 UT WOS:A1994QD55300016 PM 7885605 ER PT J AU PHELPS, JY MAYER, AR AF PHELPS, JY MAYER, AR TI CERVICAL CONE MARGINS AS A PREDICTOR FOR RESIDUAL DYSPLASIA IN POST-CONE HYSTERECTOMY SPECIMENS - REPLY SO OBSTETRICS AND GYNECOLOGY LA English DT Letter C1 WALTER REED ARMY MED CTR,GYNECOL ONCOL SERV,WASHINGTON,DC 20307. RP PHELPS, JY (reprint author), BROOKE ARMY MED CTR,DEPT OBSTET & GYNECOL,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD NOV PY 1994 VL 84 IS 5 BP 898 EP 898 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA PN551 UT WOS:A1994PN55100039 ER PT J AU RABIN, J AF RABIN, J TI LUMINANCE EFFECTS ON VISUAL-ACUITY AND SMALL LETTER CONTRAST SENSITIVITY SO OPTOMETRY AND VISION SCIENCE LA English DT Article DE VISUAL ACUITY; CONTRAST SENSITIVITY; LUMINANCE; RESOLUTION AB The purpose of this study was to evaluate the effects of luminance on visual acuity (VA) and small letter contrast sensitivity (SLCS). Computer-generated letter charts were used to measure VA and SLCS [6/7.5 (20/25) Snellen equivalent] as a function of stimulus luminance. Letter size (VA) and contrast (SLCS) were varied in equal logarithmic steps, making the task and scoring procedure comparable for the two types of measurement. Both VA and SLCS decreased with decreasing luminance, but the effect was far greater in the contrast domain. Reducing luminance from 116 cd/m2 to 0.23 cd/m2 produced a 3 x reduction in VA, but a 17 x reduction in SLCS. The greater sensitivity of SLCS to luminance endured even after correction for greater measurement variability. SLCS is a sensitive approach for detecting resolution loss undisclosed by standard measures of VA. It may be useful for monitoring visual loss from light attenuation in early cataracts, and for detecting subtle resolution loss from neural or pathologic factors in ocular and neuro-ophthalmologic disease. RP RABIN, J (reprint author), USA,AEROMED RES LAB,DIV AIRCREW HLTH PERFORMANCE,FT RUCKER,AL 36360, USA. NR 0 TC 26 Z9 27 U1 1 U2 5 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1040-5488 J9 OPTOMETRY VISION SCI JI Optom. Vis. Sci. PD NOV PY 1994 VL 71 IS 11 BP 685 EP 688 DI 10.1097/00006324-199411000-00003 PG 4 WC Ophthalmology SC Ophthalmology GA PW544 UT WOS:A1994PW54400003 PM 7885672 ER PT J AU YINON, J BULUSU, S AXENROD, T YAZDEKHASTI, H AF YINON, J BULUSU, S AXENROD, T YAZDEKHASTI, H TI MASS-SPECTRAL FRAGMENTATION PATHWAYS IN SOME GLYCOLURIL-TYPE EXPLOSIVES - A STUDY BY COLLISION-INDUCED DISSOCIATION AND ISOTOPE LABELING SO ORGANIC MASS SPECTROMETRY LA English DT Article ID ELECTRON-IMPACT FRAGMENTATION; NITRAMINES AB Electron impact (EI), chemical ionization and negative-ion chemical ionization (NCI) mass spectra of 1,4-dinitroglycoluril (DINGU), its N-15- and H-2-labeled analogues and the dimethyl-substituted derivatives were recorded. Tandem mass spectrometry with collision induced dissociation was used to study the fragmentation pathways of these compounds. It was found that the main EI fragmentation processes of DINGU are due to the cleavage of C-N bonds and some rearrangement reactions. C1 USA,ARDEC,PICATINNY ARSENAL,NJ 07806. CUNY CITY COLL,DEPT CHEM,NEW YORK,NY 10031. RP YINON, J (reprint author), WEIZMANN INST SCI,DEPT ENVIRONM SCI & ENERGY RES,IL-76100 REHOVOT,ISRAEL. NR 16 TC 13 Z9 13 U1 0 U2 5 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0030-493X J9 ORG MASS SPECTROM JI Org. Mass Spectrom. PD NOV PY 1994 VL 29 IS 11 BP 625 EP 631 DI 10.1002/oms.1210291109 PG 7 WC Chemistry, Organic; Spectroscopy SC Chemistry; Spectroscopy GA QF691 UT WOS:A1994QF69100009 ER PT J AU DAI, WL WOODWARD, PR AF DAI, WL WOODWARD, PR TI INTERACTIONS BETWEEN MAGNETOHYDRODYNAMIC DISCONTINUITIES SO PHYSICS OF PLASMAS LA English DT Article ID CLOUDS; SHOCKS AB Interactions between magnetohydrodynamical (MHD) discontinuities are studied through numerical simulations for the set of one-dimensional MHD equations. The interactions include the impact of a shock on a contact discontinuity, the collision of two shocks, and the catchup of a shock over another shock. The shocks involved in the interactions may be very strong. Each shock in an interaction may be either a fast or a slow shock. RP DAI, WL (reprint author), UNIV MINNESOTA,SCH PHYS & ASTRON,ARMY HIGH PERFORMANCE COMP RES CTR,INST SUPERCOMP,MINNEAPOLIS,MN 55415, USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 1070-664X J9 PHYS PLASMAS JI Phys. Plasmas PD NOV PY 1994 VL 1 IS 11 BP 3662 EP 3675 DI 10.1063/1.870901 PG 14 WC Physics, Fluids & Plasmas SC Physics GA PP156 UT WOS:A1994PP15600018 ER PT J AU EARLS, JP ROBLES, HA MCADAMS, HP KRISHNA, CVG AF EARLS, JP ROBLES, HA MCADAMS, HP KRISHNA, CVG TI GENERAL-CASE OF THE DAY - MALIGNANT MELANOTIC SCHWANNOMA OF THE 8TH CRANIAL NERVE SO RADIOGRAPHICS LA English DT Note DE BRAIN NEOPLASMS; SCHWANNOMA ID MR; TUMOR C1 UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL & NUCL MED,BETHESDA,MD 20814. JOHNS HOPKINS UNIV,SCH MED,DEPT RADIOL & RADIOL SCI,BALTIMORE,MD 21205. RP EARLS, JP (reprint author), WALTER REED ARMY MED CTR,DEPT RADIOL,GEORGIA AVE NW,WASHINGTON,DC 20307, USA. RI McAdams, Holman/N-8218-2015 OI McAdams, Holman/0000-0002-7044-3320 NR 11 TC 18 Z9 19 U1 0 U2 0 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0271-5333 J9 RADIOGRAPHICS JI Radiographics PD NOV PY 1994 VL 14 IS 6 BP 1425 EP 1427 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA PR453 UT WOS:A1994PR45300025 PM 7855352 ER PT J AU MCADAMS, HP ROSADODECHRISTENSON, ML MORAN, CA AF MCADAMS, HP ROSADODECHRISTENSON, ML MORAN, CA TI MEDIASTINAL HEMANGIOMA - RADIOGRAPHIC AND CT FEATURES IN 14 PATIENTS SO RADIOLOGY LA English DT Article DE ANGIOMA; MEDIASTINUM, NEOPLASMS AB PURPOSE: To characterize the imaging features of mediastinal hemangioma. MATERIALS AND METHODS: The authors retrospectively reviewed chest radiographs and computed tomographic (CT) scans from 14 patients with mediastinal hemangioma. RESULTS: Mast mediastinal hemangiomas manifested as well-marginated masses at CT. Three masses had punctate calcifications, and one had phleboliths. Five masses were of heterogeneous attenuation at unenhanced CT. Ten of 11 (91%) hemangiomas were of heterogeneous attenuation at contrast material-enhanced CT, and the following four patterns were observed: central (n = 6, 60%), mixed central and peripheral (n = 2, 20%), peripheral (n = 1, 10%), and nonspecific (n = 1, 10%) increased attenuation. Central increased attenuation was observed more frequently after administration of a bolus of contrast material than after slow infusion. CONCLUSION: Hemangiomas should be considered in the differential diagnosis of well-marginated mediastinal masses that have heterogeneous attenuation on CT scans, show central enhancement after administration of contrast material, or contain punctate calcification. C1 WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL & NUCL MED,BETHESDA,MD 20814. ARMED FORCES INST PATHOL,DEPT RADIOL PATHOL,WASHINGTON,DC 20306. ARMED FORCES INST PATHOL,DEPT PULM & MEDIASTINAL PATHOL,WASHINGTON,DC. RP MCADAMS, HP (reprint author), DUKE UNIV,MED CTR,DEPT RADIOL,BOX 3808,ERWIN RD,DURHAM,NC 27710, USA. RI McAdams, Holman/N-8218-2015 OI McAdams, Holman/0000-0002-7044-3320 NR 16 TC 32 Z9 40 U1 0 U2 0 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0033-8419 J9 RADIOLOGY JI Radiology PD NOV PY 1994 VL 193 IS 2 BP 399 EP 402 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA PN947 UT WOS:A1994PN94700026 PM 7972751 ER PT J AU MADUH, EU BASKIN, SI AF MADUH, EU BASKIN, SI TI PROTEIN-KINASE-C MODULATION OF RHODANESE-CATALYZED CONVERSION OF CYANIDE TO THIOCYANATE SO RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY LA English DT Article ID POSSIBLE REGULATORY ROLE; INDUCED NEUROTOXICITY; SUBCELLULAR-DISTRIBUTION; MITOCHONDRIAL RHODANESE; ENZYMATIC-ACTIVITY; DIACETYL MONOXIME; DOWN-REGULATION; LEUKEMIA-CELLS; RAT-BRAIN; CALCIUM AB Detoxification of cyanide is catalyzed by a sulfurtransferase, rhodanese, a phosphoprotein regulated by unknown protein kinases. In this study, we determined if a Ca2+/phospholipid-modulated phosphotransferase, protein kinase C (PKC) could modify rhodanese activity. Thiocyanate (SCN-) production as an estimate of rhodanese activity in vitro was measured in the presence or absence of exogenously added purified PKC, or 12-O-tetradecanoylphorbol acetate (TPA), a pharmacologic activator of the endogenous PKC. HI-6 (1-(2-(hydroximino)methyl))pyridinium-2-(4-(aminocarbonyl) pyridinium dimethylether) is an oxime that may dephosphorylate phosphoproteins due to the proposed phosphatase-like activity of the oximes. We examined HI-6's effect on rhodanese-catalyzed SCN- production. Bovine kidney rhodanese (0.40 mg/ml protein) was reacted with 4 mM KCN and SCN- production determined spectrophotometrically following the method of Westley (1981). Preincubating rhodanese with 20 or 100 ng of purified PKC (alpha, beta, gamma isozymes) for 5 min before initiating the reaction with 4 mM KCN as the substrate increased SCN- production by 17 or 40%, respectively, over the control (P<0.05). Rhodanese formation of SCN- decreased when the preincubation was conducted with 1 nM or 100 nM of TPA. With HI-6 at 1 or 10 mu M used in place of PKC, or TPA, rhodanese activity was increased by 6 or 14% (P<0.05), respectively, compared to control. Under the conditions examined, exogenous PKC acting as a possible phosphate acceptor, and HI-6, a potential dephosphorylating compound, increased rhodanese activity. These data are consistent with the observation that rhodanese can exist as a phosphorylated enzyme which is not active and a dephosphorylated form which is active. It is suggested that addition of purified, exogenous PKC may accept phosphate from phosphorylated rhodanese or HI-6 may dephosphorylate rhodanese, both of which stimulate the conversion of cyanide anion to the less toxic SCN-. These observations support the possibility that rhodanese may be regulated by protein phosphorylation and treatments that alter the phosphorylation state of rhodanese may affect cyanide detoxification via SCN- formation. RP MADUH, EU (reprint author), USA,MED RES INST CHEM DEF,DIV PHARMACOL,BIOCHEM PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 59 TC 5 Z9 5 U1 0 U2 0 PU P J D PUBLICATIONS LTD PI WESTBURY PA PO BOX 966, WESTBURY, NY 11590 SN 1078-0297 J9 RES COMMUN MOL PATH JI Res. Commun. Mol. Pathol. Pharmacol. PD NOV PY 1994 VL 86 IS 2 BP 155 EP 173 PG 19 WC Biochemistry & Molecular Biology; Pathology; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Pathology; Pharmacology & Pharmacy GA PV676 UT WOS:A1994PV67600003 PM 7881866 ER PT J AU KENYON, RH NIKLASSON, B JAHRLING, PB GEISBERT, T SVENSSON, L FRYDEN, A BENGTSSON, M FOBERG, U PETERS, CJ AF KENYON, RH NIKLASSON, B JAHRLING, PB GEISBERT, T SVENSSON, L FRYDEN, A BENGTSSON, M FOBERG, U PETERS, CJ TI VIROLOGICAL INVESTIGATION OF A CASE OF SUSPECTED HEMORRHAGIC-FEVER SO RESEARCH IN VIROLOGY LA English DT Article DE MARBURG VIRUS; VIRAL HEMORRHAGIC FEVER; FILOVIRION; SUB-SAHARAN AFRICA ID HEMORRHAGIC-FEVER; UNITED-STATES; EBOLA VIRUS; MICROSCOPY AB After travelling ire subsaharan Africa, an area known for sporadic cases of Marburg virus infection, a young Swedish man presented with a classical picture of severe viral haemorrhagic fever complicated by disseminated intravascular coagulation and septicaemia. Serum samples examined by electron microscopy revealed particles of a size compatible with filivirions. Indirect fluorescent antibody tests indicated transient seroconversion to Marburg virus. In lymphocyte transformation assays of cells isolated from the patient 11 months after the onset of acute disease, Marburg viral antigen was able to stimulate lymphocyte proliferation 3.9-fold; however, exhaustive attempts to isolate virus from acute phase blood cultured in vitro or in vivo from guinea pigs and monkeys failed. Data suggest that this patient may have been infected with a filovirus. This case demonstrates the difficulties that may occur in laboratory diagnosis of viral haemorrhagic fevers. C1 SWEDISH INST INFECT DIS CONTROL,DEPT VIROL,S-10521 STOCKHOLM,SWEDEN. USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702. NATL DEF RES ESTAB,FOA,ABC,S-90182 UMEA,SWEDEN. LINKOPING UNIV HOSP,DEPT INFECT DIS,S-58185 LINKOPING,SWEDEN. LINKOPING UNIV HOSP,DEPT ANAESTHESIOL,S-58185 LINKOPING,SWEDEN. NR 16 TC 9 Z9 9 U1 2 U2 4 PU EDITIONS SCIENTIFIQUES ELSEVIER PI PARIS CEDEX 15 PA 141 RUE JAVEL, 75747 PARIS CEDEX 15, FRANCE SN 0923-2516 J9 RES VIROLOGY JI Res. Virol. PD NOV-DEC PY 1994 VL 145 IS 6 BP 397 EP 406 DI 10.1016/S0923-2516(07)80046-X PG 10 WC Virology SC Virology GA QA806 UT WOS:A1994QA80600007 PM 7709077 ER PT J AU JOHNSON, AR QUIGLEY, CJ MEAD, JL AF JOHNSON, AR QUIGLEY, CJ MEAD, JL TI LARGE-STRAIN VISCOELASTIC CONSTITUTIVE MODELS FOR RUBBER .1. FORMULATIONS SO RUBBER CHEMISTRY AND TECHNOLOGY LA English DT Article ID ELASTICITY AB Constitutive models for large strain isothermal viscoelastic deformations of rubber are reviewed. The models discussed are for materials which have separable long and short term stresses, and for which the short term stresses have separable time and strain effects. They include the history integral model, an internal stress variable model, an internal stretch variable model, and an internal solid model. The internal stretch variable model and the internal solid model were motivated by molecular descriptions of rubber viscoelasticity. The material tests required to determine the constants for these large strain models are discussed. The classical problem of determining a rubber energy density function, used to describe both the long term and short term energy in these models, is reviewed. A method to assure Drucker stability, a commonly overlooked issue, is presented for experimentally determined Rivlin energy density function expansions. Also, an improved method for determining the coefficients of a Prony series, which defines a material's relaxation time spectrum, from experimental relaxation data is presented. C1 USA,RES LAB,MAT DIRECTORATE,AMSRL,MA,PC,WATERTOWN,MA 02172. RP JOHNSON, AR (reprint author), NASA,LANGLEY RES CTR,VEHICLE STRUCT DIRECTORATE,USA,RES LAB,HAMPTON,VA 23681, USA. NR 30 TC 35 Z9 35 U1 0 U2 5 PU AMER CHEMICAL SOC INC PI AKRON PA RUBBER DIV UNIV AKRON PO BOX 499, AKRON, OH 44309-0499 SN 0035-9475 J9 RUBBER CHEM TECHNOL JI Rubber Chem. Technol. PD NOV-DEC PY 1994 VL 67 IS 5 BP 904 EP 917 DI 10.5254/1.3538721 PG 14 WC Polymer Science SC Polymer Science GA QE808 UT WOS:A1994QE80800015 ER PT J AU MCCORMICK, SE SJOGREN, MH GOODMAN, ZD AF MCCORMICK, SE SJOGREN, MH GOODMAN, ZD TI A 22-YEAR-OLD MAN WITH A LIVER MASS AND MARKEDLY ELEVATED SERUM ALPHA-FETOPROTEIN SO SEMINARS IN LIVER DISEASE LA English DT Review ID HEPATITIS-B VIRUS; NODULAR REGENERATIVE HYPERPLASIA; HEPATOCELLULAR-CARCINOMA; SURFACE-ANTIGEN; DISEASE; DIAGNOSIS; TAIWAN; DNA C1 ARMED FORCES INST PATHOL,DIV HEPAT PATHOL,WASHINGTON,DC 20306. RP MCCORMICK, SE (reprint author), WALTER REED ARMY MED CTR,DEPT GASTROENTEROL,WASHINGTON,DC 20307, USA. NR 25 TC 3 Z9 3 U1 0 U2 0 PU THIEME MEDICAL PUBL INC PI NEW YORK PA 381 PARK AVE SOUTH, NEW YORK, NY 10016 SN 0272-8087 J9 SEMIN LIVER DIS JI Semin. Liver Dis. PD NOV PY 1994 VL 14 IS 4 BP 395 EP 403 DI 10.1055/s-2007-1007330 PG 9 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA PQ743 UT WOS:A1994PQ74300010 PM 7531871 ER PT J AU KELLY, JW MORRIS, MJ AF KELLY, JW MORRIS, MJ TI EMPYEMA-THORACIS - MEDICAL ASPECTS OF EVALUATION AND TREATMENT SO SOUTHERN MEDICAL JOURNAL LA English DT Article ID PARAPNEUMONIC EFFUSIONS; SURGICAL INTERVENTION; CATHETER DRAINAGE; BACTERIAL EMPYEMA; PLEURAL EMPYEMA; MANAGEMENT; THORACOTOMY; EXPERIENCE; MORTALITY; ADULTS AB Empyema thoracis is a disease that, despite centuries of study, still causes significant morbidity and mortality. Sixty-five cases were seen at Brooke Army Medical Center over an 8-year period (March 1, 1985, through March 1, 1993). The majority of the patients were men, older than 50 years of ape, with significant underlying diseases. Pneumonia remains the most common single proximate cause of empyema. Gram-positive cocci are the most frequently isolated organisms; however, empyemas due to gramnegative organisms and anaerobes are associated with higher mortality. Pleural fluid gram stains proved to be an accurate but neglected diagnostic tool in guiding initial therapy. The choice of antibiotics seemed to have no discernible impact on mortality. Closed tube thoracostomy was the initial method of drainage in most patients and had an overall success rate of 50%. Empyemas that could not be effectively drained by a single chest tube were unlikely to be drained by additional closed maneuvers. There was an overall 22% case-fatality rate with most deaths related to our inability to eradicate the empyema. C1 BROOKE ARMY MED CTR,DEPT PULM DIS CRIT CARE,FT SAM HOUSTON,TX 78234. RP KELLY, JW (reprint author), BROOKE ARMY MED CTR,MAJ MORRIS,MDP,HSHE,DEPT INFECT DIS,1950 STANLEY RD,FT SAM HOUSTON,TX 78234, USA. NR 69 TC 17 Z9 18 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD NOV PY 1994 VL 87 IS 11 BP 1103 EP 1110 DI 10.1097/00007611-199411000-00009 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA PR087 UT WOS:A1994PR08700009 PM 7973893 ER PT J AU CLARK, JY THOMPSON, IM AF CLARK, JY THOMPSON, IM TI MILITARY RANK AS A MEASURE OF SOCIOECONOMIC-STATUS AND SURVIVAL FROM PROSTATE-CANCER SO SOUTHERN MEDICAL JOURNAL LA English DT Article ID WHITE MEN; BLACK; MORTALITY; RACE AB Previous studies have shown an association between cancer survival and socioeconomic status. In the United States Armed Forces, military rank is a measure of socioeconomic status. To determine whether an association exists between socioeconomic status (as measured by military rank) and prostate cancer, we carried out a retrospective review of the clinical data from 237 patients entered into the Tumor Registry. There was no statistically significant association between rank and the stage of disease at diagnosis or actual 5-year survival. In the military, health care is provided free of charge, independent of rank, and this study showed that when there is equal access to health care, socioeconomic status does not correlate with prostate cancer outcome. Future studies comparing outcomes of prostate cancer should control for accessibility to health care. C1 BROOKE ARMY MED CTR,DEPT SURG,UROL SERV,SAN ANTONIO,TX 78234. OI Clark, Joseph/0000-0002-3817-4343 NR 12 TC 12 Z9 13 U1 1 U2 1 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD NOV PY 1994 VL 87 IS 11 BP 1141 EP 1144 DI 10.1097/00007611-199411000-00017 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA PR087 UT WOS:A1994PR08700017 PM 7973901 ER PT J AU BLACKWELL, PE AF BLACKWELL, PE TI THE LIMITS OF AIR POWER SO TECHNOLOGY REVIEW LA English DT Letter RP BLACKWELL, PE (reprint author), USA,DEPT OPERAT & PLANS,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MASS INST TECHNOL PI CAMBRIDGE PA CAMBRIDGE, MA 02139 SN 0040-1692 J9 TECHNOL REV JI Technol. Rev. PD NOV-DEC PY 1994 VL 97 IS 8 BP 6 EP 6 PG 1 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA PP073 UT WOS:A1994PP07300002 ER PT J AU POLI, MA RIVERA, VR HEWETSON, JF MERRILL, GA AF POLI, MA RIVERA, VR HEWETSON, JF MERRILL, GA TI DETECTION OF RICIN BY COLORIMETRIC AND CHEMILUMINESCENCE ELISA SO TOXICON LA English DT Article ID IMMUNOTOXINS; INTOXICATION AB A highly sensitive and specific ELISA was developed to detect ricin in biological fluids. The assay utilizes an affinity-purified goat polyclonal antibody to adsorb ricin from solution. The same antibody (biotinylated) is then used to form a sandwich, and avidin-linked alkaline phosphatase allows color development and measurement of optical density at 405 nm. Our routine assay uses a standard curve over the range of 0-10 ng/ml ricin, with accurate quantitation below 1 ng/ml (100 pg/well) in assay buffer as well as in a 1:10 dilution of human urine or 1:50 dilution of human serum spiked with ricin. Ricin measured in spiked samples demonstrated accuracy typically within 5% of the expected value in all matrices. The coefficient of variation ranged from 3-10% at 10 ng/ml to 8-25% at 2.5 ng/ml. Two variations on the routine assay were also investigated. First, lengthened incubation times and additional time for color development allowed accurate quantitation in serum dilutions as low as 1:2. Second, increased concentrations of biotinylated antibody and avidin-linked enzyme from 1:250 to 1:70 enhanced the sensitivity of the assay 10-fold, achieving a detection limit of at least 100 pg/ml (10 pg/well). The assay was also configured to a format based upon chemiluminescence, which allowed quantitation in the 0.1-1 ng/ml range, but was subject to slightly greater variability than the colorimetric assay. C1 BROOKE ARMY MED CTR,SAN ANTONIO,TX. RP POLI, MA (reprint author), USA,MED RES INST INFECT DIS,DIV TOXICOL,FREDERICK,MD 21702, USA. NR 23 TC 94 Z9 97 U1 1 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD NOV PY 1994 VL 32 IS 11 BP 1371 EP 1377 DI 10.1016/0041-0101(94)90409-X PG 7 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA PQ848 UT WOS:A1994PQ84800008 PM 7886695 ER PT J AU TACKET, CO REID, RH BOEDEKER, EC LOSONSKY, G NATARO, JP BHAGAT, H EDELMAN, R AF TACKET, CO REID, RH BOEDEKER, EC LOSONSKY, G NATARO, JP BHAGAT, H EDELMAN, R TI ENTERAL IMMUNIZATION AND CHALLENGE OF VOLUNTEERS GIVEN ENTEROTOXIGENIC ESCHERICHIA-COLI CFA/II ENCAPSULATED IN BIODEGRADABLE MICROSPHERES SO VACCINE LA English DT Article DE ENTEROTOXIGENIC ESCHERICHIA COLI; BIODEGRADABLE MICROSPHERES; ENTERAL IMMUNIZATION ID TOXIGENIC ESCHERICHIA-COLI; DIARRHEAL DISEASE; VACCINATING DAMS; TRAVELERS DIARRHEA; ORAL IMMUNIZATION; IMMUNE-RESPONSES; SUCKLING PIGS; PROTECTION; PILI; INFECTION AB The development of a safe and effective vaccine against enterotoxigenic Escherichia coli (ETEC) would be useful for travellers and for young children in endemic areas. A feasibility study of an enteral ETEC vaccine prototype consisting of colonization factor antigen II (CFA/II), containing two component antigens CS1 and CS3, encapsulated in biodegradable polymer microspheres (BPM) was conducted in healthy volunteers. Ten adult volunteers swallowed intestinal tubes on days 0, 7, 14 and 28; after collection of jejunal fluid samples, 1 mg of CFA/II in BPM was administered via the tube. Volunteers kept a diary of symptoms after each close. Secretory IgA in jejunal fluids, serum responses and circulating antibody-secreting cells (ASC) were measured before and after vaccination, The vaccine was well tolerated. Five of ten volunteers developed TgA anti-CFA/II ASC by 7 days after the last dose of vaccine; these same five vaccinees had IgA anti-CS3 ASC, and three of these five vaccinees had IgA anti-CSI ASC. Five of ten vaccinees developed rises in jejunal fluid sIgA anti-CFA/II with peak GMT of 1:42. About 8 weeks after the first dose of vaccine, ten vaccinees and ten unvaccinated control volunteers underwent challenge with 10(9) c.f.u. ETEC E24377A (0139:H28 LT(+) ST+ CS1(+) CS3 +). Ten of ten controls and seven of ten vaccinees developed diarrhoea (p = 0.11, 30% vaccine efficacy). Two of the three protected vaccinees had the highest numbers of ASC and highest sIgA titres during the course of immunization, suggesting that these responses were protective and that this vaccine development strategy has merit. Future studies with higher dosages and a different dosing schedule are planned. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20012. UNIV MARYLAND,SCH PHARM,BALTIMORE,MD 21201. RP TACKET, CO (reprint author), UNIV MARYLAND,SCH MED,DEPT MED,CTR VACCINE DEV,DIV GEOG MED,10 S PINE ST,BALTIMORE,MD 21201, USA. NR 22 TC 80 Z9 84 U1 0 U2 2 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD NOV PY 1994 VL 12 IS 14 BP 1270 EP 1274 DI 10.1016/S0264-410X(94)80038-2 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA PL791 UT WOS:A1994PL79100005 PM 7856290 ER PT J AU EDELMAN, R TAYLOR, DN WASSERMAN, SS MCCLAIN, JB CROSS, AS SADOFF, JC QUE, JU CRYZ, SJ AF EDELMAN, R TAYLOR, DN WASSERMAN, SS MCCLAIN, JB CROSS, AS SADOFF, JC QUE, JU CRYZ, SJ TI PHASE-1 TRIAL OF A 24-VALENT KLEBSIELLA CAPSULAR POLYSACCHARIDE VACCINE AND AN 8-VALENT PSEUDOMONAS O-POLYSACCHARIDE CONJUGATE VACCINE ADMINISTERED SIMULTANEOUSLY SO VACCINE LA English DT Article DE KLEBSIELLA; PSEUDOMONAS AERUGINOSA; SIMULTANEOUS ADMINISTRATION ID INTRAVENOUS IMMUNE GLOBULIN; PROTECTIVE ACTIVITY; CYSTIC-FIBROSIS; AERUGINOSA; LIPOPOLYSACCHARIDE; BACTEREMIA; ANTIBODIES; ADULTS; IMMUNOGENICITY; ANTIGENS AB A Klebsiella (K) vaccine consisting of 24 capsular polysaccharide antigens and a Pseudomonas aeruginosa (P) vaccine consisting of eight O-polysaccharide antigens conjugated to P toxin A have been developed to prevent sepsis by means of active or passive immunoprophylaxis. In search for a practical immunization schedule, the two vaccines were injected in opposite arms simultaneously (20 volunteers) or 14 days apart (21 volunteers). The vaccines were similarly well tolerated by both volunteer groups. Geometric mean antibody, concentrations and mean fold antibody rises to the 33 vaccine antigens (including toxin A) were similar in the two groups at 2 months, and the decline in antibody measured at 18 months,was also similar. Because the two vaccines were safe and similarly immunogenic in the two vaccine groups, they can be administered simultaneously to patients or plasma donors in a practical vaccination schedule. C1 UNIV MARYLAND,SCH MED,CTR VACCINE DEV,BALTIMORE,MD 21201. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BACTERIOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. SWISS SERUM & VACCINE INST,CH-3001 BERN,SWITZERLAND. RP EDELMAN, R (reprint author), UNIV MARYLAND,SCH MED,DEPT MED,DIV GEOG MED,10 S PINE ST,BALTIMORE,MD 21201, USA. NR 24 TC 25 Z9 25 U1 0 U2 2 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD NOV PY 1994 VL 12 IS 14 BP 1288 EP 1294 DI 10.1016/S0264-410X(94)80054-4 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA PL791 UT WOS:A1994PL79100008 PM 7856293 ER PT J AU COHEN, D ASHKENAZI, S GREEN, MS YAVZORI, M ORR, N SLEPON, R LERMAN, Y ROBIN, G AMBAR, R BLOCK, C TAYLOR, DN HALE, TL SADOFF, JC WIENER, M AF COHEN, D ASHKENAZI, S GREEN, MS YAVZORI, M ORR, N SLEPON, R LERMAN, Y ROBIN, G AMBAR, R BLOCK, C TAYLOR, DN HALE, TL SADOFF, JC WIENER, M TI SAFETY AND IMMUNOGENICITY OF THE ORAL ESCHERICHIA-COLI K12 SHIGELLA-FLEXNERI 2A VACCINE (ECSF2A-2) AMONG ISRAELI SOLDIERS SO VACCINE LA English DT Article DE ORAL IMMUNIZATION; SHIGELLA FLEXNERI; ECSF2A-2 HYBRID VACCINE ID SALMONELLA-TYPHI TY21A; SHIGELLA-SONNEI; IMMUNOGLOBULIN-A; SOMATIC ANTIGEN; EPIDEMIOLOGY; LIPOPOLYSACCHARIDE; TRANSMISSION; INFECTIONS; ANTIBODIES; MONKEYS AB A doubled-blind placebo-controlled study was carried out on rite safety and immunogenicity of the oral Shigella flexneri (EcSf2a-2) vaccine among Israeli soldiers. Sixty volunteers received the vaccine and 59 received placebo. Fifty-three were given the full vaccine regimen (four noses). Doses ranged between 4.1 x 10(8) and 1.1 x 10(9) c.f.u. Visits to the unit clinic for mild gastrointestinal symptoms were common after the first dose in vaccinees (13%) as compared with placebo recipients (5%), but the difference was nor significant, p = 0.12. Similarly, there was no difference between the groups for either gastrointestinal or non-gastrointestinal complaints reported by questionnaire. The vaccine strain was excreted by 69% and 67% of the vaccinees one day after receiving the second and the fourth doses, respectively. As judged by antibiotic susceptibility, phage typing and restriction fragment length polymorphism (RFLP), the vaccine strain emerged as genetically stable after replication in human gut and shedding. There was neither bacteriological nor serological evidence of transmission of the vaccine from vaccinees to placebo recipients. Eighteen of 26 (69.2%) and 11 of 30 (36.7%) vaccinees had significant IgA secreting cell responses 7 and 21 days after the first dose, respectively. Significant IgA or IgG serum antibody response to S. flexneri 2a LPS was detected in 30% of the vaccinees. These results support further evaluation of EcSf2a-2 vaccine protective efficacy infield studies. C1 WALTER REED ARMY INST RES,WASHINGTON,DC. RP COHEN, D (reprint author), ISRAEL DEF FORCES MED CORPS,MIL POST 02149,JERUSALEM,ISRAEL. NR 29 TC 5 Z9 5 U1 0 U2 0 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD NOV PY 1994 VL 12 IS 15 BP 1436 EP 1442 DI 10.1016/0264-410X(94)90153-8 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA PQ234 UT WOS:A1994PQ23400013 PM 7887022 ER PT J AU SANIN, FD VESILIND, PA MARTEL, CJ AF SANIN, FD VESILIND, PA MARTEL, CJ TI PATHOGEN REDUCTION CAPABILITIES OF FREEZE/THAW SLUDGE CONDITIONING SO WATER RESEARCH LA English DT Article DE SLUDGE; FREEZING; PATHOGENS; INDICATORS ID WATER AB Freezing and thawing sludge has become an economically feasible technique of sludge conditioning in regions where natural freezing is available. Even though the dramatic effects of freeze/thaw on dewatering have been studied extensively, its effects on the survival of pathogenic microorganisms have not been investigated. If freeze/thaw conditioning can be shown to reduce pathogenic microorganisms, then sludges treated in this fashion can be disposed of on land with less risk of health effects. In this paper, the effects of freezing rate, temperature and time in the frozen state on the removal of pathogens are tested. The response of seven indicators of microbial contamination; fecal coliforms, Salmonella, plaque forming units, fecal streptococci, poliovirus, helminths and protozoa to the freeze/thawing of both aerobically and anaerobically digested sludges is examined. Fecal coliforms, fecal streptococci, and plaque forming units are chosen as the commonly used indicators of bacteria and viruses, respectively in wastewater sludges. Pathogenic bacteria (Salmonella), virus (Poliovirus) and parasites (Ascaris suum and Cryptosporidium parvum) tested in the second phase are chosen as sample microorganisms in their respective classes. Freeze/thaw sludge conditioning is proven to be an effective means of removing most pathogenic microorganisms. Fecal streptococci are found to be the best indicator of the effectiveness of freeze/thawing on enteric bacteria. Results of this study indicate that freeze/thaw conditioning coupled with sludge digestion can significantly enhance the overall pathogenic microorganism reduction achieved in a wastewater treatment plant. Added effectiveness by freeze/thaw treatment may become critical for a plant in meeting the pathogen reduction requirements by U.S. regulations prior to any practice of land application or land disposal of sludge. C1 DUKE UNIV,DEPT CIVIL & ENVIRONM ENGN,DURHAM,NC 27708. USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. NR 22 TC 31 Z9 32 U1 1 U2 13 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0043-1354 J9 WATER RES JI Water Res. PD NOV PY 1994 VL 28 IS 11 BP 2393 EP 2398 PG 6 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA PJ238 UT WOS:A1994PJ23800017 ER PT J AU BICKELL, WH WALL, MJ PEPE, PE MARTIN, RR GINGER, VF ALLEN, MK MATTOX, KL AF BICKELL, WH WALL, MJ PEPE, PE MARTIN, RR GINGER, VF ALLEN, MK MATTOX, KL TI IMMEDIATE VERSUS DELAYED FLUID RESUSCITATION FOR HYPOTENSIVE PATIENTS WITH PENETRATING TORSO INJURIES SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID ANESTHETIZED SWINE; HEMORRHAGE; AORTOTOMY; ANEURYSM; PRESSURE; SHOCK AB Background. Fluid resuscitation may be detrimental when given before bleeding is controlled in patients with trauma. The purpose of this study was to determine the effects of delaying fluid resuscitation until the time of operative intervention in hypotensive patients with penetrating injuries to the torso. Methods. We conducted a prospective trial comparing immediate and delayed fluid resuscitation in 598 adults with penetrating torso injuries who presented with a pre; hospital systolic blood pressure less than or equal to 90 mm Hg. The study setting was a city with a single centralized system of prehospital emergency care and a single receiving facility for patients with major trauma. Patients assigned to the immediate-resuscitation group received standard fluid resuscitation before they reached the hospital and in the trauma center, and those assigned to the delayed-resuscitation group received intravenous cannulation but no fluid resuscitation until they reached the operating room. Results. Among the 289 patients who received delayed fluid resuscitation, 203 (70 percent) survived and were discharged from the hospital, as compared with 193 of the 309 patients (62 percent) who received immediate fluid resuscitation (P = 0.04). The mean estimated intraoperative blood loss was similar in the two groups. Among the 238 patients in the delayed-resuscitation group who survived to the postoperative period, 55 (23 percent) had. one or more complications (adult respiratory distress syndrome, sepsis syndrome, acute renal failure, coagulopathy, wound infection, and pneumonia), as compared with 69 of the 227 patients (30 percent) in the immediate-resuscitation group (P = 0.08). The duration of hospitalization was shorter in the delayed-resuscitation group. Conclusions. For hypotensive patients with penetrating torso injuries, delay of aggressive fluid resuscitation until operative intervention improves the outcome. C1 BAYLOR COLL MED,CORA & WEBB MADING DEPT SURG,HOUSTON,TX 77030. ST FRANCIS HOSP,DEPT EMERGENCY SERV,TULSA,OK. BAYLOR COLL MED,DEPT MED,HOUSTON,TX 77030. BEN TAUB GEN HOSP,HOUSTON,TX 77030. HOUSTON EMERGENCY MED SERV,HOUSTON,TX. BROOKE ARMY MED CTR,DEPT SURG,TRAUMA SECT,FT SAM HOUSTON,TX 78234. NR 36 TC 1028 Z9 1084 U1 2 U2 24 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD OCT 27 PY 1994 VL 331 IS 17 BP 1105 EP 1109 DI 10.1056/NEJM199410273311701 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA PN065 UT WOS:A1994PN06500001 PM 7935634 ER PT J AU BURCH, HB SOLOMON, BL WARTOFSKY, L BURMAN, KD AF BURCH, HB SOLOMON, BL WARTOFSKY, L BURMAN, KD TI DISCONTINUING ANTITHYROID DRUG-THERAPY BEFORE ABLATION WITH RADIOIODINE IN GRAVES-DISEASE SO ANNALS OF INTERNAL MEDICINE LA English DT Article DE GRAVES DISEASE; IODINE RADIOISOTOPES; HYPERTHYROIDISM; THYROID ANTAGONISTS; THYROID CRISIS ID THYROID STORM; HYPERTHYROIDISM AB Objective: To determine the relative effects on thyroid hormone levels of discontinuing antithyroid drug therapy and subsequent ablation with radioiodine in patients with hyperthyroid Graves disease. Design: A clinical trial with a prospective analysis of the relative change in thyroid hormone levels over time in response to therapy in two study groups. Setting: An outpatient endocrine clinic at a tertiary care hospital. Patients: 21 patients with a clinical diagnosis of hyperthyroid Graves disease scheduled to receive ablation therapy with radioiodine (I-131): 17 patients were pretreated with antithyroid drugs, and 4 were not. Methods: Antithyroid drugs were stopped 6 days before radioiodine therapy. Patients were monitored clinically and biochemically with measurement of free and total levels of thyroxine (T-4) and triiodothyronine (T-3) on days -6, -3, -1;the day of radioiodine therapy; and days 1, 2, 3, 4, 5, 7, and 14. Results: Before radioiodine treatment and compared with baseline measurement, the mean increase in free T-4 levels after discontinuation of antithyroid therapy was 86% (95% CI, 16.1% to 156%), with a concurrent mean increase in free T-3 levels of 71.6% (CI, 31% to 112%). Radioiodine therapy resulted in a mean decrease in free T-3 levels of 28.7% (CI, -44.1% to -13.2%), a mean decrease in total T-3 levels of 22.9% (CI, -39.4% to -6.4%), and stability in free and total T-4 levels rather than aggravation of thyrotoxicosis. A smaller group of patients not receiving antithyroid drugs experienced a course qualitatively similar to that of pretreated patients after I-131 treatment, with a mean reduction in free T-4 levels of 39.8% (CI, -69.9% to -9.7%) and a mean decrease in free T-3 levels of 49.4% (CI, -93.7% to -5.1%). Conclusion: Short-term increases in thyroid hormone levels in patients with Graves disease receiving radioiodine ablation occur primarily as a result of discontinuing antithyroid therapy rather than as a result of treatment with I-131. Stability or decrease in thyroid hormone levels, rather than further elevation, occurs during the 2-week interval after ablation therapy with I-131. Antithyroid drug therapy before radioiodine ablation may have little effect on the short-term biochemical course after I-131 therapy for Graves disease. The homogeneity of our sample regarding age, diagnosis, and general health may prevent application of these findings to other populations without further study. C1 WASHINGTON HOSP CTR,DEPT MED,WASHINGTON,DC 20010. RP BURCH, HB (reprint author), WALTER REED ARMY MED CTR,ENDOCRINE METAB SERV,WASHINGTON,DC 20307, USA. NR 22 TC 46 Z9 48 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD OCT 15 PY 1994 VL 121 IS 8 BP 553 EP & PG 0 WC Medicine, General & Internal SC General & Internal Medicine GA PL486 UT WOS:A1994PL48600001 PM 7521992 ER PT J AU SEGLETES, SB AF SEGLETES, SB TI FURTHER EXAMINATIONS ON THE THERMODYNAMIC STABILITY OF THE MIE-GRUNEISEN EQUATION OF STATE SO JOURNAL OF APPLIED PHYSICS LA English DT Article AB The Mie-Gruneisen equation of state (EOS) is further examined for restrictions upon the form of the Gruneisen parameter, which is given as a function of volume and relates the pressure and energy changes at constant volume. Employing basic thermodynamic rules and applying them to the Mie-Gruneisen EOS, a more restrictive condition is offered for the Gruneisen parameter, which extends previous work on the subject. RP SEGLETES, SB (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 10 TC 9 Z9 9 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD OCT 15 PY 1994 VL 76 IS 8 BP 4560 EP 4566 DI 10.1063/1.357288 PG 7 WC Physics, Applied SC Physics GA PM731 UT WOS:A1994PM73100013 ER PT J AU STROSCIO, MA KIM, KW YU, SG BALLATO, A AF STROSCIO, MA KIM, KW YU, SG BALLATO, A TI QUANTIZED ACOUSTIC-PHONON MODES IN QUANTUM WIRES AND QUANTUM DOTS SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID BRILLOUIN-SCATTERING; RAMAN-SCATTERING; SUPERLATTICES; FILMS AB Acoustic phonon modes in isotropic cubic media are derived for a number of quantum-wire and quantum-dot geometries of significant interest in nanoelectronics and optoelectronics. In each case, the mode amplitude is determined by requiring that the mode energy be given by that of the properly quantized phonon. For the case of cylindrical quantum wires and quantum dots with rectangular faces, the Hamiltonians for the deformation potential interactions are derived. These quantized acoustic modes and the associated deformation potential Hamiltonians provide a basis for modeling carrier-acoustic-phonon interactions in a variety of mesoscopic devices. Our new results supplement previous treatments of related piezoelectric effects in cylindrical quantum wires. C1 N CAROLINA STATE UNIV, DEPT ELECT & COMP ENGN, RALEIGH, NC 27695 USA. USA, RES LAB, ELECTR & POWER SOURCES DIRECTORATE, FT MONMOUTH, NJ 07703 USA. N CAROLINA STATE UNIV, DEPT PHYS, RALEIGH, NC 27695 USA. RP USA, RES OFF, POB 12211, RES TRIANGLE PK, NC 27709 USA. NR 25 TC 58 Z9 58 U1 0 U2 5 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD OCT 15 PY 1994 VL 76 IS 8 BP 4670 EP 4675 DI 10.1063/1.357305 PG 6 WC Physics, Applied SC Physics GA PM731 UT WOS:A1994PM73100030 ER PT J AU BEAUDRY, WT WAGNER, GW WARD, JR AF BEAUDRY, WT WAGNER, GW WARD, JR TI CUII DIAMINE COMPLEX-CATALYZED HYDROLYSIS OF PHOSPHATE TRIESTERS ADSORBED ON STRONG-BASE ION-EXCHANGE RESINS - P-31 NMR RELAXATION MEASUREMENTS SO JOURNAL OF MOLECULAR CATALYSIS LA English DT Article DE AMINE COMPLEXES; COPPER; HYDROLYSIS; ION EXCHANGE; PHOSPHATE TRIESTERS; RELAXATION MEASUREMENTS; RESINS ID DIVALENT METAL-IONS; REACTIVE PHOSPHATES; COPPER(II) CATALYSTS; MAS NMR; IODOSOBENZOATE; CLEAVAGE; POLYMER; PHOSPHODIESTERS; CHEMISTRY; ESTERS AB The Cu(II)-diamine complexes, (bipy)CuSO4 and (tmen)CuSO4, catalyze the hydrolysis of p-nitrophenyl diphenyl phosphate (PNDP) adsorbed on a strong-base ion exchange resin. Turnover is observed. The major hydrolysis products are diphenyl phosphate, p-nitrophenyl phenyl phosphate, and the ethanolysis product ethyl diphenyl phosphate (EDPP) which are observed in similar amounts in both the presence and absence of the Cu(II)-diamine catalysts. The apparent bimolecular rate constants found for the (bipy) CuSO4 and (tmen)CuSO4 catalysts are 0.023 and 0.024 M-1 s-1, respectively. CuSO4 is inactive as a catalyst. P-31 MAS NMR relaxation measurements of the stable EDPP product reveal that the Cu(II)-diamine complexes greatly enhance T1 relaxation, whereas CuSO4 has only minimal effect. These results are consistent with the complexation of neutral phosphorus esters by the Cu(II-diamine catalysts. P-31 T1 mesurements of hydrolytically-stable dimethyl methylphosphonate (DMMP) in water solutions of Cu2+, (tmen)Cu2+, and Mn2+ suggest that DMMP exchanges rapidly between inner-sphere and outer-sphere complexes in a nearly identical manner with each of these paramagnetic species. C1 USA,CTR EDGEWOOD RES DEV & ENGN,RES & TECHNOL DIRECTORATE,ABERDEEN PROVING GROUND,MD 21010. NR 25 TC 10 Z9 10 U1 1 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-5102 J9 J MOL CATAL PD OCT 13 PY 1994 VL 93 IS 2 BP 221 EP 231 DI 10.1016/0304-5102(94)00094-8 PG 11 WC Chemistry, Physical SC Chemistry GA PK763 UT WOS:A1994PK76300009 ER PT J AU WHITBURN, KD PORTER, WL DUNNE, CP AF WHITBURN, KD PORTER, WL DUNNE, CP TI BIPHASIC PROTONATION OF HYDROPHILIC CARGO AGENTS IN UNILAMELLAR PHOSPHOLIPID-VESICLES - IMPLICATIONS ABOUT CARGO LOCATION SO BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM LA English DT Article DE VESICLE; PHOSPHOLIPID; CHROMATE; CARBOXYFLUORESCEIN; PROTONATION; LEAKAGE ID HYDROXYL PERMEABILITY; LIPOSOMES; MECHANISM; PHOSPHATIDYLCHOLINE; STABILITY; PEPTIDE; RELEASE; ACID; DYE AB The commonly used cargo agents for liposome entrapment, chromate and 5(6)-carboxyflourescein (CF), have been sequestered in small unilamellar vesicles composed of dipalmitoylphosphatidylcholine through preparations involving either sonication or extrusion methods. Once loaded, these water-soluble chromophoric cargo agents have been exposed to small quantities of externally applied acid solution, which decreases the pH from neutral to approx. 6. By monitoring photometrically the time profile of the protonation of the sequestered chromophores, it is evident that the uptake of protons by each cargo agent is biphasic. An immediate spectral change is followed by further change over 10-40 min, where the extent of protonation occurring in each time frame is approximately equal. The vesicles themselves are unaffected by the induced pH change. The leakages of both chromate and CF from loaded sonicated vesicles were monitored at both 25 degrees C and 45 degrees C. Overall, the leakage processes exhibited a deceleration over time. The biphasic protonation and decelerating leakage phenomena are together interpreted in terms of a mechanism of cargo loading involving an intercalation of the water-soluble agent along with water into the vesicle bilayer, rather than involving internal capture of the cargo inside the vesicles, or through electrostatic interactions with the bilayer surfaces. In addition, the measured extents of cargo loading are more consistent with calculated estimates of loading through bilayer intercalation than with those for internal capture. C1 USA,NATICK RES DEV & ENGN CTR,SUSTAINABIL DIRECTORATE,NATICK,MA 01760. RP WHITBURN, KD (reprint author), FRAMINGHAM STATE COLL,DEPT CHEM & FOOD SCI,FRAMINGHAM,MA 01701, USA. NR 42 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0005-2760 J9 BBA-LIPID LIPID MET JI Biochim. Biophys. Acta-Lipids Lipid Metab. PD OCT 6 PY 1994 VL 1214 IS 3 BP 243 EP 252 DI 10.1016/0005-2760(94)90070-1 PG 10 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA PM284 UT WOS:A1994PM28400004 PM 7918606 ER PT J AU KRAUSS, M JENSEN, JO HAMEKA, HF AF KRAUSS, M JENSEN, JO HAMEKA, HF TI ELECTRONIC-STRUCTURE OF THE EXCITED-STATES AND PHENOL FLUORESCENCE SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID PHOTOELECTRON-SPECTROSCOPY; AMINO-ACIDS; TYROSINE; FIELD AB The excitation energies of phenol and the deprotonated anion have been determined at geometries relevant to both the absorption and fluorescence spectra using first-order configuration interaction methods. Optimized geometries were calculated for the ground and first excited singlet and triplet state of both neutral and anion molecules. Solvatochromic shifts are predicted to be very small since the ground and singlet excited state dipole moments are very similar. The fluorescent shift is dominated by the differences in the vertical transition energies at the equilibrium geometries of the ground and excited state. Anion absorption and fluorescence shifts are substantially to the red of those found for the neutral molecule. Ordering and assignment of the tripler valence states of neutral and deprotonated phenol are determined to be different. Experimental observation that anion formation strongly deactivates fluorescence is related to these differences. Coupling of the first excited singlet to its cognate triplet state is suggested as the quenching mechanism in the anion, and the same process occurs more weakly in the neutral species. C1 USA, EDGEWOOD RES DEV & ENGN CTR, ABERDEEN PROVING GROUND, MD 21010 USA. UNIV PENN, DEPT CHEM, PHILADELPHIA, PA 19104 USA. RP KRAUSS, M (reprint author), NIST, CTR ADV RES BIOTECHNOL, ROCKVILLE, MD 20850 USA. NR 19 TC 27 Z9 28 U1 0 U2 13 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD OCT 6 PY 1994 VL 98 IS 40 BP 9955 EP 9959 DI 10.1021/j100091a004 PG 5 WC Chemistry, Physical SC Chemistry GA PK740 UT WOS:A1994PK74000004 ER PT J AU COBB, PW DEGEN, DR CLARK, GM CHEN, SF KUHN, JG GROSS, JL KIRSHENBAUM, MR SUN, JH BURRIS, HA VONHOFF, DD AF COBB, PW DEGEN, DR CLARK, GM CHEN, SF KUHN, JG GROSS, JL KIRSHENBAUM, MR SUN, JH BURRIS, HA VONHOFF, DD TI ACTIVITY OF DMP-840, A NEW BIS-NAPHTHALIMIDE, ON PRIMARY HUMAN TUMOR COLONY-FORMING-UNITS SO JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Article ID STEM-CELLS; INVITRO; ASSAY AB Background: DMP 840 {(R,R)-2,2'-[1,2-ethanediylbis[imino(1-methyl-2,1- ethanediyl)]]-bis[5-nitro-1H-benz[de]iso[quinoline-1,3(2H)-dione]dimethane- sulfonate; NSC-D640430} is one in a series of bis-naphthalimides that binds DNA with high affinity and has sequence specificity to multiple G and C bases, It is also a potent inhibitor of RNA synthesis. DMP 840 has been selected for clinical evaluation on the basis of a broad spectrum of activity (including cures) in human tumors in murine models. Purpose: We evaluated DMP 840 in a human tumor clonogenic assay to estimate what plasma concentrations may be necessary for clinical cytotoxic activity and to determine what types of tumors potentially might be primary targets for initial phase II studies. Methods: A soft-agar cloning system assay was used to determine the in vitro effects of DMP 840 against cells from biopsy specimens of colorectal, breast, lung, ovarian, renal cell, stomach, and bladder cancers and from other tumor types. A total of 260 human tumor specimens were exposed continuously during the assay to DMP 840; 103 were assessable (20 colonies or more on control plates and 30% or less survival for the positive control). An in vitro response was defined as at least a 50% decrease in tumor colony formation resulting from drug exposure compared with controls. Results: In vitro responses were seen in 10% (one of 10), 54% (55 of 101), 80% (82 of 103), and 89% (82 of 92) of specimens tested at 0.01, 0.1, 1.0, and 10.0 mu g/mL of DMP 840, respectively. At a concentration of 0.1 mu g/mL, specific activity was seen against melanoma (80%) and against renal ce11 (80%), ovarian (63%), breast (54%), non-small-cell lung (42%), and colorectal cancers (33%). DMP 840 demonstrated activity in tumor specimens resistant in vitro to methotrexate (88%), doxorubicin (58%), platinum (57%), cyclophosphamide (53%), vinblastine (53%), etoposide (53%), fluorouracil (37%), and paclitaxel (36%). Conclusions: At in vitro concentrations of 0.1 mu g/mL as a continuous exposure, DMP 840 has activity against a variety of human tumors, including a subgroup resistant in vitro to standard antineoplastic agents. Implications: Further clinical development of DMP 840 is warranted. C1 CANC THERAPY & RES CTR S TEXAS,SAN ANTONIO,TX 78229. UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX. CHEKTEC CORP,BALTIMORE,MD. DUPONT MERCK PHARMACEUT CO,WILMINGTON,DE 19880. RP COBB, PW (reprint author), BROOKE ARMY MED CTR,HEMATOL ONCOL CLIN,FT SAM HOUSTON,TX 78234, USA. RI Gross, Jorge/G-9138-2012 NR 18 TC 15 Z9 16 U1 0 U2 0 PU NATL CANCER INSTITUTE PI BETHESDA PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0027-8874 J9 J NATL CANCER I JI J. Natl. Cancer Inst. PD OCT 5 PY 1994 VL 86 IS 19 BP 1462 EP 1465 DI 10.1093/jnci/86.19.1462 PG 4 WC Oncology SC Oncology GA PJ101 UT WOS:A1994PJ10100010 PM 8089865 ER PT J AU ASCHER, DP BLATT, SP HENDRIX, CW ROBERTS, C FOWLER, A AF ASCHER, DP BLATT, SP HENDRIX, CW ROBERTS, C FOWLER, A TI VALIDATION OF POST-ACIDIFICATION P24-ANTIGEN AS A PROGNOSTIC MARKER FOR HIV DISEASE PROGRESSION SO AIDS PATIENT CARE LA English DT Article ID IMMUNODEFICIENCY VIRUS TYPE-1; P24 ANTIGEN; IMMUNE-COMPLEXES; INFECTION; COUNTS; ASSAY; CHILDREN; COHORT; AIDS AB The HIV p24 antigen has demonstrated predictive value for HIV disease progression independent of CD4 count. An acidification procedure has resulted in 40-70 percent p24 antigen positivity across HIV clinical stages, although the predictive value of post-acidification p24 antigen for disease progression has not been fully validated. We hypothesized that there would be significant differences in p24 antigen positivity between matched cohorts of rapid progressors (RP) and slow progressors (SP). Seven hundred sixteen people enrolled in the USAF HIV Natural History Study were stratified according to the slope of CD4 change over time. RP were defined as people in the fastest 15 percent of CD4 decline who also progressed at least 2 Walter Reed (WR) stages. SP were defined as people in the slowest 15 percent of CD4 decline who did not progress more than 1 WR stage. Twenty-five RP were matched to 25 SP based on initial CD4 count (median CD4 RP = 750, SP=720), WR stage, age, and duration of follow-up (RP=1086 days, SP=1126 days) with no significant differences between groups. Ten/25 (40 percent) of the RP and 2/25 (8 percent) of the SP were p24 antigen positive by the acidification assay (p=0.018). Using the standard assay, 6/25 (24 percent) of RP and 1/25 (4 percent) of SP were p24 antigen positive (p=0.098). There were no quantitative differences between p24 antigen positive RP and SP. p24 antigen as detected with the acidification assay was predictive for HIV rapid progressors when compared to slow progressors in early stage HIV patients even when controlling for initial CD4 count, age, and duration of follow-up. C1 WALTER REED ARMY INST RES,DIV RETROVIROL,WASHINGTON,DC 20307. SRA TECHNOL INC,ROCKVILLE,MD. RP ASCHER, DP (reprint author), WILFORD HALL USAF MED CTR,DEPT PEDIAT & MED,INFECT DIS SERV,SAN ANTONIO,TX, USA. RI Hendrix, Craig/G-4182-2014 OI Hendrix, Craig/0000-0002-5696-8665 NR 17 TC 0 Z9 0 U1 1 U2 1 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0893-5068 J9 AIDS PATIENT CARE JI Aids Patient Care PD OCT PY 1994 VL 8 IS 5 BP 251 EP 253 DI 10.1089/apc.1994.8.251 PG 3 WC Public, Environmental & Occupational Health; Nursing SC Public, Environmental & Occupational Health; Nursing GA PN863 UT WOS:A1994PN86300003 ER PT J AU CAMPOSESTEVE, MA LAIRD, JR KUFS, WM WORTHAM, DC AF CAMPOSESTEVE, MA LAIRD, JR KUFS, WM WORTHAM, DC TI SIDE-BRANCH OCCLUSION WITH DIRECTIONAL CORONARY ATHERECTOMY - INCIDENCE AND RISK-FACTORS SO AMERICAN HEART JOURNAL LA English DT Article ID ANGIOPLASTY AB Side-branch occlusion is a recognized complication of directional coronary atherectomy (DCA). To evaluate the incidence, risk factors, and clinical outcome of side-branch compromise, we analyzed our first 100 consecutive atherectomies of native coronary arteries. Seventy-eight patients had 122 side branches at risk, 21 (17%) of which demonstrated compromised flow after DCA. Origin of the side branch from the culprit atheroma and preexisting side-branch ostial stenosis were highly predictive of this complication in 20 of 55 (p < 0.05) and 14 of 31 (p < 0.05) lesions, respectively. There was one non-Q-wave myocardial infarction, no emergency surgeries, and no deaths. In conclusion, side-branch loss after DCA occurs with a frequency similar to balloon angioplasty and was well tolerated in our patient population. Side branches that originate directly from culprit lesions or that have significant ostial narrowing have a higher incidence of this complication. C1 WALTER REED ARMY MED CTR,SERV CARDIOL,WASHINGTON,DC 20307. RP CAMPOSESTEVE, MA (reprint author), BROOKE ARMY MED CTR,SERV CARDIOL,FT SAM HOUSTON,TX 78234, USA. NR 8 TC 5 Z9 5 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-8703 J9 AM HEART J JI Am. Heart J. PD OCT PY 1994 VL 128 IS 4 BP 686 EP 690 DI 10.1016/0002-8703(94)90265-8 PG 5 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA PJ929 UT WOS:A1994PJ92900007 PM 7942438 ER PT J AU CARETTI, DM PULLEN, PV PREMO, LA KUHLMANN, WD AF CARETTI, DM PULLEN, PV PREMO, LA KUHLMANN, WD TI RELIABILITY OF RESPIRATORY INDUCTIVE PLETHYSMOGRAPHY FOR MEASURING TIDAL VOLUME DURING EXERCISE SO AMERICAN INDUSTRIAL HYGIENE ASSOCIATION JOURNAL LA English DT Article AB This study was designed to determine the reliability of measurements of respiratory volumes obtained with a respiratory inductive plethysmograph (RIP) during exercise. Tidal volumes (V(T)) from the RIP were compared with simultaneous flowmeter volumes in 8 healthy subjects at 5 incremental work rates of 60, 90, 120, 150, and 180 W during cycling and treadmill exercise. During cycling, average RIP and flowmeter values did not differ significantly at work rates below 180 W for 63% of the subjects. Average RIP and flowmeter V(T) were similar at work rates below 180 W for 50% of the subjects, and for 83% of the subjects at intensities below 150 W. The variability in these results may be attributed to several factors including RIP calibration errors and slippage of the RIP elastic bands containing the inductive coils. Correlations of breath-by-breath flowmeter and RIP V(T) were significant for subjects during cycling (R = 0.73, P < 0.05) and treadmill exercise (R = 0.78, P < 0.05). These findings suggest that the RIP should be considered a semi-quantitative method for measurements of tidal volume during exercise with and without respirator wear. RP CARETTI, DM (reprint author), USA,EDGEWOOD RES,CTR DEV & ENGN,RESP PROTECT TECHNOL TEAM,ABERDEEN PROVING GROUND,MD 21010, USA. NR 13 TC 15 Z9 16 U1 0 U2 4 PU AMER INDUSTRIAL HYGIENE ASSOC PI FAIRFAX PA 2700 PROSPERITY AVE #250, FAIRFAX, VA 22031-4307 SN 0002-8894 J9 AM IND HYG ASSOC J JI Am. Ind. Hyg. Assoc. J. PD OCT PY 1994 VL 55 IS 10 BP 918 EP 923 DI 10.1080/15428119491018411 PG 6 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA PM526 UT WOS:A1994PM52600006 PM 7977031 ER PT J AU JAMES, WD ODOM, RB AF JAMES, WD ODOM, RB TI ECZEMA REVISITED - A STATUS-REPORT BASED UPON CURRENT TEXTBOOKS OF DERMATOLOGY - REPLY SO AMERICAN JOURNAL OF DERMATOPATHOLOGY LA English DT Article C1 UNIV CALIF SAN FRANCISCO,SAN FRANCISCO,CA 94143. RP JAMES, WD (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0193-1091 J9 AM J DERMATOPATH JI Am. J. Dermatopathol. PD OCT PY 1994 VL 16 IS 5 BP 523 EP 524 PG 2 WC Dermatology SC Dermatology GA PL216 UT WOS:A1994PL21600008 ER PT J AU SKELTONJ, HG SMITH, KJ LUPTON, GP AF SKELTONJ, HG SMITH, KJ LUPTON, GP TI COLLAGENOUS SPHERULOSIS IN A SCHWANNOMA SO AMERICAN JOURNAL OF DERMATOPATHOLOGY LA English DT Note DE COLLAGENOUS SPHERULOSIS; SCHWANNOMA ID BREAST; TUMOR AB ''Collagenous spherulosis'' is the term used to describe striking concentric and radiating formations of collagen in tumors. It was originally used for these formations in epithelial tumors of the breast and subsequently in tumors of salivary glands. Recently, the histologic, immunohistochemical, and ultrastructural features were described in a chondroid syringoma. We report a case of collagenous spherulosis in a schwannoma. Routine histologic sections showed a circumscribed tumor in which the predominant feature was radiating fibrillar structures that tended to compress the cellular component of the tumor. Immunohistochemical studies showed that the cells were positive for glial fibrillary acidic protein (GFAP) and S-100 protein but negative for keratin. EMA showed a positive reaction in a thin band of cells around the periphery of the tumor consistent with perineurial cells. Type IV collagen stained around the periphery of the collagen formations. Electron microscopy revealed that the material was consistent with collagen. Our findings were essentially identical to those reported in the chondroid syringoma. This case confirms the findings of the previous study and shows that these unusual formations are not confined to tumors of epithelial origin. Because the architecture of the tumor is distorted, special stains may be required for correct diagnosis. C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. RP SKELTONJ, HG (reprint author), ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306, USA. NR 11 TC 16 Z9 16 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0193-1091 J9 AM J DERMATOPATH JI Am. J. Dermatopathol. PD OCT PY 1994 VL 16 IS 5 BP 549 EP 553 DI 10.1097/00000372-199410000-00018 PG 5 WC Dermatology SC Dermatology GA PL216 UT WOS:A1994PL21600018 PM 7528476 ER PT J AU HIGBY, K SUITER, CR PHELPS, JY SILERKHODR, T LANGER, O AF HIGBY, K SUITER, CR PHELPS, JY SILERKHODR, T LANGER, O TI NORMAL VALUES OF URINARY ALBUMIN AND TOTAL PROTEIN EXCRETION DURING PREGNANCY SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article; Proceedings Paper CT 14th Annual Meeting of the Society-of-Perinatal-Obstetricians CY JAN 24-29, 1994 CL LAS VEGAS, NV SP SOC PERINATAL OBSTETRICIANS DE URINARY PROTEIN EXCRETION; URINARY ALBUMIN EXCRETION; PREGNANCY ID MICROALBUMINURIA; PREECLAMPSIA; CREATININE; PREDICTOR AB OBJECTIVE: Our purpose was to determine the normal 24-hour excretion values of urinary albumin and total protein in healthy pregnant women. STUDY DESIGN: We evaluated 270 healthy pregnant women less than or equal to 35 years old without a history of diabetes, hypertension, pyelonephritis, preeclampsia, or renal or connective tissue disease. Adequacy of 24-hour collection was determined by creatinine excretion. RESULTS: The mean protein excretion in 24 hours was 116.9 mg, upper 95% confidence limit 259.4 mg. The mean albumin excretion in 24 hours was 11.8 mg, upper 95% confidence limit 28.7 mg. Both protein and albumin excretion increased after 20 weeks of gestation. No patient had evidence of microalbuminuria, defined as urinary albumin excretion >30 mg/L. CONCLUSION: These data support 260 mg per 24 hours of urinary protein and 29 mg per 24 hours of albumin as the upper limit of normal in pregnancy. Albumin accounts for a small fraction of total urinary protein excretion. C1 UNIV TEXAS,HLTH SCI CTR,DEPT OBSTET & GYNECOL,SAN ANTONIO,TX 78284. RP HIGBY, K (reprint author), BROOKE ARMY MED CTR,DEPT OBSTET & GYNECOL,FT SAM HOUSTON,TX 78234, USA. NR 25 TC 64 Z9 69 U1 0 U2 7 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD OCT PY 1994 VL 171 IS 4 BP 984 EP 989 PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA PN360 UT WOS:A1994PN36000019 PM 7943114 ER PT J AU VANDERGRACHT, J AF VANDERGRACHT, J TI SIMPLE METHOD FOR DEMONSTRATING FRAUNHOFER-DIFFRACTION SO AMERICAN JOURNAL OF PHYSICS LA English DT Article ID LASER AB A simple and inexpensive method is presented for displaying Fraunhofer diffraction in a classroom environment. Laser printers are used to create the input patterns and the diffraction patterns can be viewed without the use of a laser or lenses. RP VANDERGRACHT, J (reprint author), USA,RES LAB,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 13 TC 2 Z9 2 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0002-9505 J9 AM J PHYS JI Am. J. Phys. PD OCT PY 1994 VL 62 IS 10 BP 934 EP 937 DI 10.1119/1.17684 PG 4 WC Education, Scientific Disciplines; Physics, Multidisciplinary SC Education & Educational Research; Physics GA PJ023 UT WOS:A1994PJ02300017 ER PT J AU AVSICZUPANC, T POLJAK, M FURLAN, P KAPS, R XIAO, SY LEDUC, JW AF AVSICZUPANC, T POLJAK, M FURLAN, P KAPS, R XIAO, SY LEDUC, JW TI ISOLATION OF A STRAIN OF A HANTAAN VIRUS FROM A FATAL CASE OF HEMORRHAGIC-FEVER WITH RENAL SYNDROME IN SLOVENIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID POLYMERASE CHAIN-REACTION; NEPHROPATHIA-EPIDEMICA VIRUS; SEQUENCE-ANALYSIS; UNITED-STATES; DOBRAVA VIRUS; CELL-CULTURE; HANTAVIRUS; RNA; YUGOSLAVIA; DISEASE AB Hemorrhagic fever with renal syndrome (HFRS) has been serologically confirmed in Slovenia during the last seven years. There is evidence that three hantaviruses (Hantaan, Puumala, and a newly described form termed Dobrava) circulate simultaneously in this area. Recently, a hantavirus was isolated from the urine and brain tissue of a fatal case of HFRS. Positive immunofluorescent reactions with reference human sera and monoclonal antibodies were first recognized after the second cell culture passage. Extensive cross-reactivity between our isolate and prototype Hantaan virus, strain 76-118, and Hantaan-like isolates from the former Yugoslavia, Fojnica and Plitvice, was revealed by enzyme-linked immunosorbent assay with specific rat antisera. The reaction pattern of the isolate was similar to the prototype Hantaan virus by indirect immunofluorescent assay with a panel of monoclonal antibodies. Furthermore, the specificity of the isolates was confirmed by analysis of polymerase chain reaction products of this virus with five restriction endonucleases. This appears to be the first isolation of a strain of prototype Hantaan virus from a fatal case of HFRS in Europe. C1 REG HOSP NOVO MESTO,NOVO MESTO,SLOVENIA. NIAID,BETHESDA,MD 20892. USA,MED RES INST INFECT DIS,FREDERICK,MD. RP AVSICZUPANC, T (reprint author), UNIV LJUBLJANA FAC MED,INST MICROBIOL,ZALOSKA 4,LJUBLJANA 61105,SLOVENIA. RI Xiao, Shu-Yuan/E-2215-2012 NR 28 TC 15 Z9 16 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1994 VL 51 IS 4 BP 393 EP 400 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA PN553 UT WOS:A1994PN55300004 PM 7943563 ER PT J AU STRICKMAN, D SMITH, CD CORCORAN, KD NGAMPOCHJANA, M WATCHARAPICHAT, P PHULSUKSOMBATI, D TANSKUL, P DASCH, GA KELLY, DJ AF STRICKMAN, D SMITH, CD CORCORAN, KD NGAMPOCHJANA, M WATCHARAPICHAT, P PHULSUKSOMBATI, D TANSKUL, P DASCH, GA KELLY, DJ TI PATHOLOGY OF RICKETTSIA-TSUTSUGAMUSHI INFECTION IN BANDICOTA-SAVILEI, A NATURAL HOST IN THAILAND SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SCRUB TYPHUS AB Following rodent surveys in a rice-growing area of central Thailand where we found Bandicota savilei, B. indica, and Rattus rattus infected with Rickettsia tsutsugamushi, we performed a study of pathogenesis of R. tsutsugamushi in laboratory-reared B. savilei. Eight animals were injected with saline and 19 animals were injected with 4.0 x 10(6) mouse 50% lethal dose units of a strain of R. tsutsugamushi isolated from a human in central Thailand. Animals were evaluated at intervals for IgG and IgM antibodies to R. tsutsugamushi by an indirect immunoperoxidase assay, the presence of the pathogen in liver and spleen by murine inoculation, and the pathology of representative tissues by gross and microscopic examination. The infected animals began to show internal evidence of mild illness 7-14 days after inoculation, and exhibited no changes in behavior. Total white blood cell counts decreased on day seven (including lymphocytes and polymorphonuclear leukocytes), followed by an almost equal increase on day 14. Gross pathology noted at necropsy was limited to slight liver and spleen enlargement accompanied by low numbers of abscesses and fibrinous tags present in the abdominal cavity. In addition to the gross morphologic changes, histopathologic lesions noted were all mild, consisting of vasculitis of the lung, activation of the mononuclear phagocyte system, abdominal mesothelial cell hyperplasia, and peritonitis. Rickettsiae were isolated from liver and spleen on days 0, 7, and 14, but not thereafter. Specific antibody response was first observed on day 14, peaked on day 21, and it decreased to levels observed in uninfected animals between days 120 and 180. The course of infection in B. savilei was less prolonged and more pathologic than that reported in wild southeast Asian Rattus species. C1 USN,MED RES INST,VIRAL & RICKETTSIAL DIS PROGRAM,BETHESDA,MD. ARMED FORCES RES INST MED SCI,ROYAL THAI ARMY COMPONENT,DEPT VET MED,BANGKOK,THAILAND. ARMED FORCES RES INST MED SCI,USA MED COMPONENT,DEPT MED ENTOMOL,BANGKOK,THAILAND. ARMED FORCES RES INST MED SCI,USA MED COMPONENT,DEPT VET MED,BANGKOK,THAILAND. RP STRICKMAN, D (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT RICKETTSIOL DIS,WASHINGTON,DC 20307, USA. NR 18 TC 19 Z9 19 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1994 VL 51 IS 4 BP 416 EP 423 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA PN553 UT WOS:A1994PN55300008 PM 7943567 ER PT J AU PICHYANGKUL, S SAENGKRAI, P WEBSTER, HK AF PICHYANGKUL, S SAENGKRAI, P WEBSTER, HK TI PLASMODIUM-FALCIPARUM PIGMENT INDUCES MONOCYTES TO RELEASE HIGH-LEVELS OF TUMOR-NECROSIS-FACTOR-ALPHA AND INTERLEUKIN-1-BETA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID CEREBRAL MALARIA; MACROPHAGES; CACHECTIN; TNF; NEUTROPHILS; PATHOLOGY AB We show that high levels of tumor necrosis factor-alpha (TNF-alpha) activity were consistently detected when monocytes were cocultured with Plasmodium falciparum schizont stage-parasitized erythrocytes that subsequently ruptured. Isolated pigment recovered from ruptured schizonts was found to specifically induce monocyte release of high levels of TNF-alpha and interleukin-1 beta (IL-1 beta). Particulate free-culture supernatant that contained various soluble parasite macromolecules induced relatively low levels of TNF-alpha and IL-1 beta. When isolated pigment was treated with protease, the monokine inducing-activity was abolished. Isolated pigment prepared from different natural isolates of P. falciparum stimulated variable levels of monokine production. We propose that in vivo, malaria pigment from parasites sequestered in the host microvasculature is a physiologically relevant moiety that interacts with monocytes and stimulates the release of TNF-alpha and IL-1 beta. These observations suggest that malaria pigment may be a virulence factor in the monokine-mediated induction of organ-specific and systemic pathophysiology in falciparum malaria. RP PICHYANGKUL, S (reprint author), ARMED FORCES RES INST MED SCI,US MED COMPONENT,DEPT IMMUNOL & PARASITOL,315-6 RAJVITHI RD,BANGKOK 10400,THAILAND. NR 21 TC 128 Z9 129 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1994 VL 51 IS 4 BP 430 EP 435 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA PN553 UT WOS:A1994PN55300010 PM 7943569 ER PT J AU OROURKE, TJ WEISS, GR NEW, P BURRIS, HA RODRIGUEZ, G ECKHARDT, J HARDY, J KUHN, JG FIELDS, S CLARK, GM VONHOFF, DD AF OROURKE, TJ WEISS, GR NEW, P BURRIS, HA RODRIGUEZ, G ECKHARDT, J HARDY, J KUHN, JG FIELDS, S CLARK, GM VONHOFF, DD TI PHASE-I CLINICAL-TRIAL OF ORMAPLATIN (TETRAPLATIN, NSC-363812) SO ANTI-CANCER DRUGS LA English DT Article DE NEUROTOXICITY; ORMAPLATIN; PHASE I TRIAL ID CARCINOMA CELL-LINES; OVARIAN-CANCER; PERIPHERAL NEUROTOXICITY; CISPLATIN NEUROTOXICITY; PLATINUM ANALOGS; SENSITIVITY; RESISTANCE; NEUROPATHY; COMPLEXES; TOXICITY AB Ormaplatin is a platinum analog that was developed because of an altered toxicity profile and non-cross resistance to cisplatin in both in vitro and in vivo models. To determine the toxicities and maximum tolerated dose of ormaplatin on a daily times five schedule, patients with refractory solid tumors received ormaplatin on five consecutive days at nine dose levels ranging from 1.0 to 15.0 mg/m(2)/day. A total of 35 patients received 70 cycles of therapy. Nausea and vomiting and myelosuppression were moderate and not dose-limiting. Dose-limiting neurotoxicity, consisting of a sensory peripheral neuropathy, was seen in all five patients who received cumulative doses greater than or equal to 165 mg/m(2). This neurotoxicity was symptomatic in all patients and caused significant functional impairment in four patients with inability to walk in two patients. A sensitive atomic absorption spectroscopy analysis performed for one patient at the 13.0 mg/m(2)/day dose level showed a Cp(max) of 163 ng/ml and a t(1/2) of 10.9 min for free platinum. A phase II dose could not be determined due to the onset of peripheral neuropathy at low cumulative doses and not at absolute dose levels. C1 UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284. CANC THERAPY & RES CTR S TEXAS,SAN ANTONIO,TX 78229. RP OROURKE, TJ (reprint author), BROOKE ARMY MED CTR,HEMATOL ONCOL SERV,FT SAM HOUSTON,TX 78234, USA. FU NCI NIH HHS [P01-CA54-174-02, CM 07305-01]; NCRR NIH HHS [5M01RR01346-09] NR 27 TC 33 Z9 33 U1 1 U2 1 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0959-4973 J9 ANTI-CANCER DRUG JI Anti-Cancer Drugs PD OCT PY 1994 VL 5 IS 5 BP 520 EP 526 DI 10.1097/00001813-199410000-00002 PG 7 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA PM436 UT WOS:A1994PM43600002 PM 7858283 ER PT J AU SIDWELL, RW HUFFMAN, JH BARNARD, DL SMEE, DF WARREN, RP CHIRIGOS, MA KENDE, M HUGGINS, J AF SIDWELL, RW HUFFMAN, JH BARNARD, DL SMEE, DF WARREN, RP CHIRIGOS, MA KENDE, M HUGGINS, J TI ANTIVIRAL AND IMMUNOMODULATING INHIBITORS OF EXPERIMENTALLY-INDUCED PUNTA-TORO VIRUS-INFECTIONS SO ANTIVIRAL RESEARCH LA English DT Article DE PUNTA TORO VIRUS; ANTIVIRAL; RIBAVIRIN ANALOG; IMMUNOMODULATOR ID ALPHA-BETA INTERFERON; PHLEBOVIRUS INFECTIONS; RIBAVIRIN; MICE; 3-DEAZAGUANINE; INDUCTION; AGENT; RNA AB A major component of a US Army Medical Research and Development Command-supported program to discover and develop new drugs for the treatment of Rift Valley fever, sandfly fever, and Crimean-Congo hemorrhagic fever has been to study candidate test materials against hepatotropic infections of C57BL/6 mice induced by the related but less biohazardous Punta Toro virus (PTV). The effects of 75 compounds, some of which were considered immunomodulators in their primary mechanism of activity, were studied in the PTV infection model. Of these, ribavirin, ribamidine, ribavirin 2',3',5'-triacetate, tiazofurin, tiazofurin-5'-monophosphate, tiazofurin-2',3',5'-triacetate, selenazofurin, pyrazofurin, 3-deazaguanine, and 3-deazaguanosine were considered significantly inhibitory, acting against the infection by a direct antiviral (non-immunomodulatory) fashion. These compounds had therapeutic indices (TI) ranging from greater than or equal to 5 to 65, using increased survivors as the evaluation parameter. Immunomodulators considered significantly inhibitory to this infection were poly (ICLC), ampligen, human recombinant interferon-alpha-A/D, MVE-1, MVE-2, AM-3, AM-5, mannozym, bropirimine, CL246,738, phenyleneamine, and 7-thia-8-oxoguanosine. Utilizing increased survivor numbers as measure of activity, these inhibitors had TI ranging from greater than or equal to 16 to 1000. Other antiviral effects exerted by the active compounds included reduction of hepatic icterus, lowered serum glutamic oxaloacetic and pyruvic acid transaminases, and inhibition of recoverable serum and liver virus titers. The active immunomodulators were significantly effective when therapy was initiated as late as 48 h after virus inoculation, at a time when clinical signs of the PTV disease were being manifested in the animal. C1 USA,MED RES INST INFECT DIS,DIV VIROL,FT DETRICK,MD 21702. RP SIDWELL, RW (reprint author), UTAH STATE UNIV,INST ANTIVIRAL RES,LOGAN,UT 84322, USA. NR 42 TC 32 Z9 37 U1 1 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD OCT PY 1994 VL 25 IS 2 BP 105 EP 122 DI 10.1016/0166-3542(94)90100-7 PG 18 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA PK666 UT WOS:A1994PK66600003 PM 7847873 ER PT J AU OWENS, FJ AF OWENS, FJ TI DC-MAGNETIC-FIELD DEPENDENCE OF RF PENETRATION DEPTH AND VORTEX DYNAMICS IN HG-PB-BA-CA-CU-O, 135 K SUPERCONDUCTOR SO APPLIED SUPERCONDUCTIVITY LA English DT Article; Proceedings Paper CT 7th Conference on Superconductivity and Applications CY SEP 07-09, 1994 CL NEW YORK INST SUPERCONDUCT, BUFFALO, NY SP New York State Inst Superconduct HO NEW YORK INST SUPERCONDUCT ID MICROWAVE-ABSORPTION OBSERVATION; CRYSTALS; DISSIPATION; LATTICE AB The vortex dynamics and flux trapping behavior are studied in the newly synthetized superconductor Hg0.7Pb0.3Ba2Ca2Cu3O8+x (T-c = 135 K) by measuring the magnetic field dependence of the r.f. penetration depth at 10 MHz. The penetration depth is shown to depend linearly on B-1/2 With a change in slope occurring at a field B* which is associated with the depinning transition in agreement with theoretical predictions. The irreversibility line at 10 MHz is measured from the temperature dependence of B*. A comparison of the field dependence of the r.f. penetration depth in Hg,Pb1223 with that in Y-Ba-Cu-O indicates the Hg,Pb1223 superconductor more strongly traps flux at 77 K compared to Y-Ba-Cu-O. C1 CUNY HUNTER COLL,DEPT PHYS,NEW YORK,NY 10021. RP OWENS, FJ (reprint author), USA,CTR ARMAMENT RES & DEV,PICATINNY,NJ 07806, USA. NR 15 TC 0 Z9 0 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0964-1807 J9 APPL SUPERCOND JI Appl. Supercond. PD OCT-DEC PY 1994 VL 2 IS 10-12 BP 651 EP 655 PG 5 WC Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA RE624 UT WOS:A1994RE62400006 ER PT J AU WEISS, DJ GEARY, RS WUSTENBERG, W BUCCI, TJ PERMAN, V BAUMEL, IP DACRE, JC AF WEISS, DJ GEARY, RS WUSTENBERG, W BUCCI, TJ PERMAN, V BAUMEL, IP DACRE, JC TI THE COMPARATIVE METABOLISM OF DIISOPROPYL METHYLPHOSPHONATE IN MINK AND RATS SO ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article AB This study reports the metabolism of carbon-(14)labeled diisopropyl methylphosphonate (DIMP) in mink and rats, undertaken to better understand the dose-related mortality reported for mink in a previous study. In both male and female mink and rats, DIMP was rapidly absorbed after oral administration; it was metabolized by a saturable pathway to a single metabolite, isopropyl methylphosphonate (IMPA), which was rapidly excreted, primarily in the urine (90%). Fecal radioactivity, also identified as IMPA, was 1.7-3.1% of the administered dose. Female rats had a slower rate of conversion of DIMP to IMPA and less total excretion of IMPA than male rats. Metabolism of DIMP administered intravenously was not very different from that given orally in both species. These data indicate that mink absorb, metabolize, and excrete DIMP (as IMPA) in a manner very similar to mice, rats, and dogs. C1 USA,BIOMED RES & DEV LAB,GEOCENTERS INC,FREDERICK,MD 21702. UNIV MINNESOTA,DEPT VET PATHOBIOL,ST PAUL,MN 55108. SW RES INST,SAN ANTONIO,TX 78228. VITAL HEART SYST INC,ST PAUL,MN 55458. PATHOL ASSOCIATES INC,JEFFERSON,AR 72079. NR 15 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0090-4341 J9 ARCH ENVIRON CON TOX JI Arch. Environ. Contam. Toxicol. PD OCT PY 1994 VL 27 IS 3 BP 420 EP 425 PG 6 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA PD585 UT WOS:A1994PD58500021 PM 7944557 ER PT J AU STILES, BG SEXTON, FW GUEST, SB OLSON, MA HACK, DC AF STILES, BG SEXTON, FW GUEST, SB OLSON, MA HACK, DC TI CHARACTERIZATION OF MONOCLONAL-ANTIBODIES AGAINST NAJA-NAJA-OXIANA NEUROTOXIN-I SO BIOCHEMICAL JOURNAL LA English DT Article ID AMINO-ACID-SEQUENCE; VENOM POSTSYNAPTIC NEUROTOXINS; ALPHA-BUNGAROTOXIN; ACETYLCHOLINE-RECEPTOR; 3-DIMENSIONAL STRUCTURE; CRYSTAL-STRUCTURE; ELAPID SNAKE; RESOLUTION; BINDING; PEPTIDE AB Seven monoclonal antibodies (mAbs) were developed against neurotoxin I (NT-1), a protein from central Asian cobra (Naja naja oxiana) venom which binds specifically to nicotinic acetylcholine receptor (AchR). All of the mAbs cross-reacted with another long-chain post-synaptic neurotoxin, Bungarus multi-cinctus alpha-bungarotoxin (alpha-BT), but not Naja naja kaouthia alpha-cobratoxin, in an enzyme-linked immunosorbent assay (e.l.i.s.a.). Short-chain post-synaptic neurotoxins like Naja naja atra cobrotoxin, Laticauda semifasciata erabutoxin b, or N. n. oxiana neurotoxin II did not cross-react with the NT-1 mAbs, but an antigen(s) found in Dendroaspis polylepis, Acanthophis antarcticus and Pseudechis australis venoms was immunoreactive. The e.l.i.s.a. readings for dithiothreitol-reduced NT-1 and NT-1 mAbs ranged from 13 to 27% of those for native toxin but reduced alpha-BT was not immunoreactive. Synthetic NT-1 peptides were used in epitope-mapping studies and two, non-contiguous regions (Cys(15)-Tyr(23) and Lys(25)-Gly(33) or Pro(17)-Lys(25) and Asp(29)-Lys(37)) were recognized by the NT-1 mAbs. The NT-1 mAbs individually inhibited 31-71% of alpha-BT binding to AchR in vitro and afforded a slight protective effect in vivo with a toxin:antibody mole ratio of 1:1.5. This report is the first to describe mAbs which recognize and protect against a heterologous, long-chain, post-synaptic neurotoxin from snake venom. C1 USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21702. USA,MED RES INST INFECT DIS,DIV MED,FREDERICK,MD 21702. RP STILES, BG (reprint author), USA,MED RES INST INFECT DIS,DIV TOXICOL,FT DETRICK,FREDERICK,MD 21702, USA. NR 42 TC 10 Z9 11 U1 1 U2 2 PU PORTLAND PRESS PI LONDON PA 59 PORTLAND PLACE, LONDON, ENGLAND W1N 3AJ SN 0264-6021 J9 BIOCHEM J JI Biochem. J. PD OCT 1 PY 1994 VL 303 BP 163 EP 170 PN 1 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA PL764 UT WOS:A1994PL76400024 PM 7945236 ER PT J AU ROY, BF DAUPHIN, MM WARDEN, DL PIERCE, PF RICHERT, JR AF ROY, BF DAUPHIN, MM WARDEN, DL PIERCE, PF RICHERT, JR TI CSF ANTIBODIES FOR DYNORPHIN BIND SYNTHETIC STAPHYLOCOCCUS-AUREUS REPLICATION PROTEIN-B-275-290 SO BIOLOGICAL PSYCHIATRY LA English DT Note DE AUTOIMMUNITY; DYNORPHIN; EPITOPE; MOLECULAR MIMICRY; HEROIN ABUSE; STAPHYLOCOCCUS AUREUS ID SEQUENCE-ANALYSIS; CLONING C1 VET AFFAIRS MED CTR,PSYCHIAT SERV,ALBANY,NY. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. GEORGETOWN UNIV,SCH MED,WASHINGTON,DC. RP ROY, BF (reprint author), ALBANY MED COLL,DEPT PSYCHIAT A164,47 NEW SCOTLAND AVE,ALBANY,NY 12208, USA. NR 15 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD OCT 1 PY 1994 VL 36 IS 7 BP 482 EP 484 DI 10.1016/0006-3223(94)90645-9 PG 3 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA PJ339 UT WOS:A1994PJ33900009 PM 7811846 ER PT J AU BUI, LM KEEN, CL DUBICK, MA AF BUI, LM KEEN, CL DUBICK, MA TI INFLUENCE OF 12-WEEK NICOTINE TREATMENT AND DIETARY COPPER AN BLOOD-PRESSURE AND INDEXES OF THE ANTIOXIDANT SYSTEM IN MALE SPONTANEOUS HYPERTENSIVE RATS SO BIOLOGICAL TRACE ELEMENT RESEARCH LA English DT Article DE SHR; TRACE ELEMENTS; ANTIOXIDANT ENZYMES; NICOTINE; HYPERTENSION; DRUG-NUTRIENT; ZINC; COPPER; IRON; MANGANESE ID GLUTATHIONE-PEROXIDASE; SUPEROXIDE-DISMUTASE; LIPID-PEROXIDATION; FREE-RADICALS; ABNORMALITIES; CERULOPLASMIN; HYPERTROPHY; DEFICIENCY; SCAVENGER; DISEASE AB Nicotine treatment and copper (Cu) deficiency have been associated with an increased production of reactive oxygen species that may contribute to the development and/or progression of cardiovascular diseases (CVD). The present study investigated the influence of dietary Cu intake on the response to chronic nicotine treatment in spontaneous hypertensive rats (SHR) with respect to tissue trace mineral levels, several components of the oxidant defense system, and Lipid peroxidation rates. SHR weighing 100-110 g were fed a Cu deficient diet (-Cu) (0.5 mu g Cu/g) for 14 d prior to nicotine treatment. C1 UNIV CALIF DAVIS,DEPT NUTR,DAVIS,CA 95616. UNIV CALIF DAVIS,DEPT INTERNAL MED,DAVIS,CA 95616. LETTERMAN ARMY INST RES,DIV MIL TRAUMA RES,SAN FRANCISCO,CA 94129. USA,INST SURG RES,FT SAM HOUSTON,TX 78234. NR 39 TC 6 Z9 6 U1 0 U2 1 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 SN 0163-4984 J9 BIOL TRACE ELEM RES JI Biol. Trace Elem. Res. PD OCT-NOV PY 1994 VL 46 IS 1-2 BP 67 EP 78 DI 10.1007/BF02790068 PG 12 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism SC Biochemistry & Molecular Biology; Endocrinology & Metabolism GA PW527 UT WOS:A1994PW52700005 PM 7888285 ER PT J AU SUNG, C BLANEY, SM COLE, DE BALIS, FM DEDRICK, RL AF SUNG, C BLANEY, SM COLE, DE BALIS, FM DEDRICK, RL TI A PHARMACOKINETIC MODEL OF TOPOTECAN CLEARANCE FROM PLASMA AND CEREBROSPINAL-FLUID SO CANCER RESEARCH LA English DT Article ID TOPOISOMERASE-I INHIBITOR; PHASE-I; CONTINUOUS INFUSION; CAMPTOTHECIN; REPLICATION AB We present a physiological pharmacokinetic model that describes the plasma and cerebrospinal fluid (CSF) concentrations of topotecan [(S)-9-dimethylaminomethyl-10-hydroxycamptothecin hydrochloride, SKandF 104863-A, NSC 609699] following i.v. and intraventricular administrations in monkeys. The model consists of three physical spaces: the CSF, the plasma, and a body compartment. The model incorporates such processes as reversible conversion of topotecan lactone to an inactive hydroxy acid form, microvascular exchange between CSF and plasma, bulk CSF flow, exchange between plasma and body compartments, and elimination of drug from the plasma compartment. Several parameters in the model mere obtained from published literature on the physiology of the monkey. The model mas then fit to the plasma and CSF data to deduce the other parameters. Calculated clearances of topotecan lactone and total drug from the CSF after intraventricular injection mere 3.9 and 2.2 ml/h, respectively. Clearances of topotecan lactone and total drug from the plasma following a 10-min infusion were 26.3 liters/h/m(2) and 17.8 liters/h/m(2), respectively. The calculated ratios of the area under the concentration curve in the CSP following i.v. infusion to the area under the concentration curve in plasma mere 0.11 and 0.19 for topotecan and total drug, respectively, indicating significant CSF penetration. The volume of distribution was 0.77 liters/kg, which represents distribution in a volume approximating total body mater. The forward and reverse rate constants for the lactone-to-hydroxy acid conversion mere 1.0 and 0.29 h(-1), respectively. Comparison of the clearances (normalized to body surface area) with values reported for mice and humans shows reasonable similarity across species. This pharmacokinetic model may help guide future development and refinement of clinical protocols, especially in the treatment of diseases of the central nervous system. C1 NCI,PEDIAT BRANCH,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC. RP SUNG, C (reprint author), NIH,NATL CTR RES RESOURCES,BIOMED ENGN & INSTRUMENTAT PROGRAM,BLDG 13,ROOM 3N17,BETHESDA,MD 20892, USA. NR 17 TC 45 Z9 45 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 1994 VL 54 IS 19 BP 5118 EP 5122 PG 5 WC Oncology SC Oncology GA PH774 UT WOS:A1994PH77400019 PM 7923128 ER PT J AU ADEBONOJO, SA AF ADEBONOJO, SA TI DELAYED PERFORATION OF THE ESOPHAGUS BY A CLOSED THORACOSTOMY TUBE SO CHEST LA English DT Letter RP ADEBONOJO, SA (reprint author), WALTER REED ARMY MED CTR,DEPT CARDIOTHORAC SURG,WASHINGTON,DC 20307, USA. NR 2 TC 3 Z9 3 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD OCT PY 1994 VL 106 IS 4 BP 1306 EP 1306 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA PM304 UT WOS:A1994PM30400074 PM 7924529 ER PT J AU OLSEN, SB AYALA, B TANG, DB JACKSON, MR GOMEZ, ER ALVING, BM AF OLSEN, SB AYALA, B TANG, DB JACKSON, MR GOMEZ, ER ALVING, BM TI ENHANCEMENT OF PLATELET DEPOSITION BY CROSS-LINKED HEMOGLOBIN IN A RAT CAROTID ENDARTERECTOMY MODEL SO CIRCULATION LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT PY 1994 VL 90 IS 4 BP 345 EP 345 PN 2 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA PN417 UT WOS:A1994PN41701887 ER PT J AU ISENBARGER, DW ARONSON, NE AF ISENBARGER, DW ARONSON, NE TI LYTIC VERTEBRAL LESIONS - AN UNUSUAL MANIFESTATION OF AIDS-ASSOCIATED KAPOSIS-SARCOMA SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID CAT-SCRATCH DISEASE; BACILLARY EPITHELIOID ANGIOMATOSIS; ACQUIRED IMMUNODEFICIENCY SYNDROME; OSSEOUS LESIONS; BONE-MARROW; SOFT-TISSUE; PATIENT; INVOLVEMENT; INFECTION; ROCHALIMAEA AB The differential diagnosis of neovascular skin lesions in patients with AIDS includes Kaposi's sarcoma and bacillary angiomatosis. It has been suggested that the radiographic presence of lytic bone lesions in association with these skin lesions supports a diagnosis of bacillary angiomatosis. We present a case of disseminated Kaposi's sarcoma in which evidence of lytic vertebral disease was seen on computed tomography; the histopathologic characteristics of the osseous lesions are described. Findings of magnetic resonance imaging implied more diffuse marrow involvement. Human immunodeficiency virus-associated osseous manifestations of rochalimaea infection and Kaposi's sarcoma are reviewed. C1 WALTER REED ARMY MED CTR,INFECT DIS SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. NR 25 TC 20 Z9 20 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD OCT PY 1994 VL 19 IS 4 BP 751 EP 755 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA PK857 UT WOS:A1994PK85700018 PM 7803643 ER PT J AU DOOLEY, DP REDDY, RK SMITH, CE AF DOOLEY, DP REDDY, RK SMITH, CE TI COCCIDIOIDOMYCOSIS PRESENTING AS AN OMENTAL MASS SO CLINICAL INFECTIOUS DISEASES LA English DT Letter ID PERITONITIS C1 WILFORD HALL USAF MED CTR,LACKLAND AFB,TX 78236. DWIGHT D EISENHOWER ARMY MED CTR,FT GORDON,GA. RP DOOLEY, DP (reprint author), BROOKE ARMY MED CTR,DEPT MED,FT SAM HOUSTON,TX 78234, USA. NR 10 TC 6 Z9 6 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD OCT PY 1994 VL 19 IS 4 BP 802 EP 803 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA PK857 UT WOS:A1994PK85700037 PM 7803662 ER PT J AU MAGILL, AJ GROGL, M JOHNSON, SC GASSER, RA AF MAGILL, AJ GROGL, M JOHNSON, SC GASSER, RA TI VISCERAL INFECTION DUE TO LEISHMANIA-TROPICA IN A VETERAN OF OPERATION-DESERT-STORM WHO PRESENTED 2 YEARS AFTER LEAVING SAUDI-ARABIA SO CLINICAL INFECTIOUS DISEASES LA English DT Letter C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. KEESLER MED CTR,BILOXI,MS. RP MAGILL, AJ (reprint author), WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307, USA. NR 6 TC 37 Z9 38 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD OCT PY 1994 VL 19 IS 4 BP 805 EP 806 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA PK857 UT WOS:A1994PK85700040 PM 7803664 ER PT J AU TORTELLA, FC DECOSTER, MA AF TORTELLA, FC DECOSTER, MA TI KAPPA-OPIOIDS - THERAPEUTIC CONSIDERATIONS IN EPILEPSY AND CNS INJURY SO CLINICAL NEUROPHARMACOLOGY LA English DT Review DE KAPPA OPIOIDS; SEIZURES; ANTICONVULSANTS; NEUROPROTECTIN; STROKE; TRAUMA; ENADOLINE ID FOCAL CEREBRAL-ISCHEMIA; SPINAL-CORD INJURY; AMINO-ACID RECEPTORS; NOR-BINALTORPHIMINE; SELECTIVE AGONIST; N-TYPE; RAT; DYNORPHIN; CI-977; GLUTAMATE AB Epilepsy and CNS injury identify a heterogenous group of diseases, many of which exhibit refractoriness (e.g., the partial epilepsies) to established drug therapy or, as in the case of brain and spinal cord injuries of variable etiologies, remain a formidable target for successful drug development. As such, the search for safe, effective antiepileptic and neuroprotective drugs continues. Although several CNS targets have been identified for drug development, especially the excitatory amino acid receptors, free-radical systems, gangliosides, and nitric oxide, etc., the opioid system and its diversity of receptors have, until recently, received little attention. This review attempts to focus on one opioid system, namely the kappa receptor class of opioid ligands, specifically addressing the potential anticonvulsant and neuroprotective properties of the arylacetamide series of kappa opioid analgesics as novel pharmacotherapeutic approaches to the treatment of epilepsy, stroke, or trauma related brain or spinal cord injury. RP TORTELLA, FC (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT MED NEUROSCI,NEUROPHARMACOL BRANCH,WASHINGTON,DC 20307, USA. NR 77 TC 35 Z9 36 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0362-5664 J9 CLIN NEUROPHARMACOL JI Clin. Neuropharmacol. PD OCT PY 1994 VL 17 IS 5 BP 403 EP 416 DI 10.1097/00002826-199410000-00002 PG 14 WC Clinical Neurology; Pharmacology & Pharmacy SC Neurosciences & Neurology; Pharmacology & Pharmacy GA PH647 UT WOS:A1994PH64700002 PM 9316689 ER PT J AU BABONIS, T WEIR, MR KELLY, PC KROBER, MS AF BABONIS, T WEIR, MR KELLY, PC KROBER, MS TI PROGRESSION OF TYMPANOMETRY AND ACOUSTIC REFLECTOMETRY - FINDINGS IN CHILDREN WITH ACUTE OTITIS-MEDIA SO CLINICAL PEDIATRICS LA English DT Article ID MIDDLE-EAR; AMOXICILLIN-CLAVULANATE; EFFUSION; MYRINGOTOMY; THERAPY; TRIAL; IDENTIFICATION AB The presence of middle ear effusion (MEE) following acute otitis media (AOM) has been assessed by impedance tympanometry and acoustic reflectometry but has not been assessed serially from the time of presentation for AOM in the same group of patients. This descriptive study examined serial measurements by tympanometry and reflectometry in children with clinical AOM at the time of diagnosis, 3 to 5 days later, and at final follow-up 12 to 15 days after diagnosis. The study entry criteria were conservative in order to represent obvious cases of AOM and included 90 patients representing 107 ears. The objective was co describe the evolution of instrumental findings and to attempt to identify unique patient subpopulations with differing prognoses. We found that combined use of initial tympanometry and reflectometry, while yielding intriguing results, does not allow for identification of subpopulations with good or poor progression for MEE clearance at 2-week follow-up. It is our conclusion that initial tympanometry and reflectometry add to the cost of AOM diagnosis without clear benefit for the individual patient. C1 TEXAS A&M UNIV,SCOTT & WHITE MEM HOSP & CLIN,SHERWOOD & BRINDLEY FDN,COLL MED,HLTH SCI CTR,TEMPLE,TX 76508. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. MADIGAN ARMY MED CTR,TACOMA,WA 98431. NR 33 TC 5 Z9 5 U1 0 U2 1 PU WESTMINSTER PUBL INC PI GLEN HEAD PA 708 GLEN COVE AVE, GLEN HEAD, NY 11545 SN 0009-9228 J9 CLIN PEDIATR JI Clin. Pediatr. PD OCT PY 1994 VL 33 IS 10 BP 593 EP 600 DI 10.1177/000992289403301004 PG 8 WC Pediatrics SC Pediatrics GA PM026 UT WOS:A1994PM02600004 PM 7813138 ER PT J AU RASZKA, WV TRINH, TT ZAWADSKY, PM AF RASZKA, WV TRINH, TT ZAWADSKY, PM TI MULTIFOCAL MYCOBACTERIUM-INTRACELLULARE OSTEOMYELITIS IN AN IMMUNOCOMPETENT CHILD SO CLINICAL PEDIATRICS LA English DT Article ID MYCOBACTERIUM-AVIUM-INTRACELLULARE; COMPLEX INFECTION; TRIMETHOPRIM-SULFAMETHOXAZOLE; AIDS; AZITHROMYCIN; ETHAMBUTOL; RIFABUTIN; DISEASE AB We report the successful treatment of disseminated Mycobacterium intracellulare osteomyelitis, without evidence of other visceral involvement, in a previously healthy, HIV-negative, 2-year-old female using a 23-month regimen of antimicrobial agents that included 18 months of oral therapy with azithromycin, rifabutin, trimethoprim-sulfamethoxazole (TMP/SMX), and ethambutol. C1 WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. RP RASZKA, WV (reprint author), WILLIAM BEAUMONT ARMY MED CTR,DEPT PEDIAT,EL PASO,TX 79920, USA. NR 25 TC 17 Z9 17 U1 0 U2 0 PU WESTMINSTER PUBL INC PI GLEN HEAD PA 708 GLEN COVE AVE, GLEN HEAD, NY 11545 SN 0009-9228 J9 CLIN PEDIATR JI Clin. Pediatr. PD OCT PY 1994 VL 33 IS 10 BP 611 EP 616 DI 10.1177/000992289403301007 PG 6 WC Pediatrics SC Pediatrics GA PM026 UT WOS:A1994PM02600007 PM 7813141 ER PT J AU BORRADORI, L CALDWELL, JB BRIGGAMAN, RA JAMES, WD YANCEY, KB AF BORRADORI, L CALDWELL, JB BRIGGAMAN, RA JAMES, WD YANCEY, KB TI PASSIVE TRANSFER OF AUTOANTIBODIES FROM A PATIENT WITH MUTILATING EPIDERMOLYSIS-BULLOSA ACQUISITA (EBA) INDUCES SPECIFIC ALTERATIONS IN ME SKIN OF NEONATAL MICE SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 NIH,DERMATOL BRANCH,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307. UNIV N CAROLINA,DEPT DERMATOL,CHAPEL HILL,NC 27514. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD OCT PY 1994 VL 42 IS 3 BP A454 EP A454 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA PD505 UT WOS:A1994PD50500557 ER PT J AU SMITH, KJ SKELTON, H YEAGER, J WAGNER, K ANGRITT, P AF SMITH, KJ SKELTON, H YEAGER, J WAGNER, K ANGRITT, P TI DECREASED CD7 EXPRESSION IN CUTANEOUS INFILTRATES OF HIV-1+ PATIENTS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES, WASHINGTON, DC USA. ARMED FORCES INST PATHOL, BETHESDA, MD USA. NATL NAVAL MED CTR, DEPT DERMATOL, BETHESDA, MD USA. HENRY M JACKSON FDN, BETHESDA, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD OCT PY 1994 VL 42 IS 3 BP A463 EP A463 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA PD505 UT WOS:A1994PD50500602 ER PT J AU MODIANO, SH VANDERHOFF, JA AF MODIANO, SH VANDERHOFF, JA TI MULTICHANNEL INFRARED-ABSORPTION SPECTROSCOPY OF SOLID-PROPELLANT FLAMES SO COMBUSTION AND FLAME LA English DT Note RP MODIANO, SH (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 9 TC 4 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0010-2180 J9 COMBUST FLAME JI Combust. Flame PD OCT PY 1994 VL 99 IS 1 BP 187 EP 189 DI 10.1016/0010-2180(94)90089-2 PG 3 WC Thermodynamics; Energy & Fuels; Engineering, Multidisciplinary; Engineering, Chemical; Engineering, Mechanical SC Thermodynamics; Energy & Fuels; Engineering GA PH996 UT WOS:A1994PH99600012 ER PT J AU GARNER, JM AF GARNER, JM TI UNTITLED SO COMPARATIVE STRATEGY LA English DT Letter RP GARNER, JM (reprint author), USA,WASHINGTON,DC 20310, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 0149-5933 J9 COMP STRATEGY PD OCT-DEC PY 1994 VL 13 IS 4 BP 459 EP 459 DI 10.1080/01495939408403002 PG 1 WC International Relations; Political Science SC International Relations; Government & Law GA PV253 UT WOS:A1994PV25300009 ER PT J AU MUNDIE, TG EASA, D FINN, KC STEVENS, EL HASHIRO, G BALARAMAN, V AF MUNDIE, TG EASA, D FINN, KC STEVENS, EL HASHIRO, G BALARAMAN, V TI EFFECT OF BASE-LINE LUNG COMPLIANCE ON THE SUBSEQUENT RESPONSE TO POSITIVE END-EXPIRATORY PRESSURE IN VENTILATED PIGLETS WITH NORMAL LUNGS SO CRITICAL CARE MEDICINE LA English DT Article DE POSITIVE-PRESSURE RESPIRATION; POSITIVE END-EXPIRATORY PRESSURE; LUNG COMPLIANCE; LUNG VOLUME MEASUREMENTS; HEMODYNAMICS; NEONATAL INTENSIVE CARE; PULMONARY GAS EXCHANGE; VASCULAR RESISTANCE; CARDIAC OUTPUT; MECHANICAL VENTILATION ID INDUCED PULMONARY-HYPERTENSION; ACUTE RESPIRATORY-FAILURE; YOUNG PIGLETS; ATELECTASIS; SURFACTANT; PEEP; DEPRESSION; ANESTHESIA; CHILDREN; INFANTS AB Objective: To determine the pulmonary function and hemodynamic effects of incremental positive end-expiratory pressure in two groups of normal ventilated newborn piglets with different baseline dynamic lung compliance. Design: Prospective, controlled, intervention study. Setting: Animal laboratory. Interventions: One group of piglets (inflation group) was prepared with 3 cm H2O (0.29 kPa) positive end-expiratory pressure and a maximal lung inflation to increase baseline lung compliance as compared with the other group (no-inflation group), prepared by 3 hrs of ventilation at zero end-expiratory pressure. Both groups were then subjected to a sequence of incremental positive end-expiratory pressures from 0 to 12 cm H2O (0 to 1.18 kPa) in 2-cm increments for 15-min periods at each level followed by a 60-min recovery period at zero end-expiratory pressure. Measurements and Main Results: Pulmonary function, hemodynamic and blood gas data were collected at each positive end-expiratory pressure value and at 15-min intervals during recovery. Baseline dynamic lung compliance was 5.2 +/- 0.3 mL/cm H2O (53.04 +/- 3.06 mL/kPa) in the inflation group and 2.5 +/- 0.1 mL/cm H2O (25.5 +/- 1.02 mL/kPa) in the no-inflation group. No differences were found in any other pulmonary function, hemodynamic or blood gas value at baseline. Incremental positive end-expiratory pressure resulted in a decrease in dynamic lung compliance and an increase in end-expiratory lung volume in both groups of piglets; dynamic lung compliance was greater in the inflation group at all times. No differences were found in end-expiratory lung volume between groups. Hemodynamic changes in both groups of piglets included: decreased cardiac output and increased pulmonary vascular resistance and systemic vascular resistance. The changes in cardiac output (-23% vs. -32%), pulmonary vascular resistance (+53% vs. +95%), and systemic vascular resistance (17% vs. 51%) were less in the inflation group as compared with the no-inflation group. Conclusions: Baseline dynamic lung compliance is an important determinant of the subsequent effect of positive end-expiratory pressure on pulmonary function and hemodynamics in the ventilated piglet with normal lungs. C1 KAPIOLANI MED CTR WOMEN & CHILDREN,JOHN A BURNS SCH MED,DEPT PEDIAT,HONOLULU,HI 96826. TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI. NR 31 TC 4 Z9 4 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD OCT PY 1994 VL 22 IS 10 BP 1631 EP 1638 PG 8 WC Critical Care Medicine SC General & Internal Medicine GA PK865 UT WOS:A1994PK86500020 PM 7924376 ER PT J AU LEE, MS DUNCAN, MB KEELING, JH AF LEE, MS DUNCAN, MB KEELING, JH TI 2 UNUSUAL CASES OF ANHIDROSIS SO CUTIS LA English DT Article ID CONGENITAL HORNERS SYNDROME; DISORDERS AB Many disorders produce anhidrosis, including abnormalities of the central or peripheral nervous system. Tumors, infarcts, injuries, or hemorrhages of the brain can be the cause. We describe two patients with anhidrosis due to neurologic causes. One patient had an acquired complete left unilateral anhidrosis without an ipsilateral Horner's syndrome. The other patient showed the second case associated with congenital Horner's syndrome reported in the dermatologic literature. The patient with unilateral anhidrosis had multiple infarcts noted on computed axial tomography and magnetic resonance imaging of his head and spine, which were thought to be the cause of his anhidrosis. Congenital Horner's syndrome is rare, but can be differentiated from other causes of Horner's syndrome by the finding of hypochromia of the affected iris, as in our patient. We present two patients with anhidrosis due to conditions with which the practitioner may not be familiar. C1 BROOKE ARMY MED CTR,DEPT MED,FT SAM HOUSTON,TX 78234. NR 12 TC 2 Z9 3 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0011-4162 J9 CUTIS JI Cutis PD OCT PY 1994 VL 54 IS 4 BP 261 EP 265 PG 5 WC Dermatology SC Dermatology GA PL768 UT WOS:A1994PL76800010 PM 7805410 ER PT J AU ACKLEY, SF SULLIVAN, CW AF ACKLEY, SF SULLIVAN, CW TI PHYSICAL CONTROLS ON THE DEVELOPMENT AND CHARACTERISTICS OF ANTARCTIC SEA-ICE BIOLOGICAL COMMUNITIES - A REVIEW AND SYNTHESIS SO DEEP-SEA RESEARCH PART I-OCEANOGRAPHIC RESEARCH PAPERS LA English DT Article ID WINTER MIXED LAYER; WEDDELL-SCOTIA SEA; PACK-ICE; MICROBIAL COMMUNITIES; EDGE ZONE; MCMURDO-SOUND; EUPHAUSIA-SUPERBA; PHYTOPLANKTON; MICROALGAE; ABUNDANCE AB Ice structures found in Antarctic sea ice and related morphological processes are summarized, including: frazil ice growth; the flooded snow layer; pressure ridge induced flooding; thermally driven brine drainage; and platelet-ice formation. The associated colonization, physiological adaptation, and growth of sea ice biota within these structures, to the levels presently identifiable, are also reviewed. A strong interaction exists between the physical processes that form, evolve and deteriorate sea ice, and the biological communities located within sea ice. Variability of ice structure and associated biological communities over small spatial scales necessitated analysis of the biological component in combination with physical and chemical properties of the sea ice. The ice microstructure provides indications of the growth and evolution of the ice properties and initially defines how ice biota colonize the ice. The light, temperature,space and nutrient fields within which ice biota subsequently adapt and grow, are the other key determinants of the biology. While the ice microstructure shapes the localized biological response; relatively large regions of pack ice have characteristic microstructures. Regional patterns of biomass and biological productivity within the Antarctic sea ice zone may therefore be predictable as a result of these physical-biological associations. Examples from the drifting pack ice and fast ice zones of the Weddell and Ross Seas are given. C1 UNIV SO CALIF,DEPT BIOL SCI,LOS ANGELES,CA 90089. RP ACKLEY, SF (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 83 TC 140 Z9 147 U1 2 U2 23 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0967-0637 J9 DEEP-SEA RES PT I JI Deep-Sea Res. Part I-Oceanogr. Res. Pap. PD OCT PY 1994 VL 41 IS 10 BP 1583 EP 1604 DI 10.1016/0967-0637(94)90062-0 PG 22 WC Oceanography SC Oceanography GA QB438 UT WOS:A1994QB43800009 ER PT J AU ROEBUCK, BD WALSH, ME RACINE, CH REITSMA, L STEELE, B NAM, SI AF ROEBUCK, BD WALSH, ME RACINE, CH REITSMA, L STEELE, B NAM, SI TI PREDATION OF DUCKS POISONED BY WHITE PHOSPHORUS - EXPOSURE AND RISK TO PREDATORS SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE WHITE PHOSPHORUS; YELLOW PHOSPHORUS; WATERFOWL; TOXICITY; PREDATION AB White phosphorus (P-4) has been identified as the cause of mortality for dabbling ducks and swans at an estuarine salt marsh in Alaska. Predation of ducks poisoned by P-4 was monitored to assess the extent and range of predator exposures to P-4 Avian tissues were analyzed for P-4 by gas chromatography. We observed that both sick and dead dabbling ducks were common prey of bald eagles (Haliaeetus leucocephalus), herring gulls (Larus argentatus), and common ravens (Corvus corax). Frank signs of P-4 intoxication attracted predators and rendered the ducks easy prey. White phosphorus was found in the tissue remains of ducks that had been preyed upon, thus providing positive evidence that predators were exposed to P-4. Although P-4 varied widely among individuals, P-4 was generally highest in the gizzard contents followed by fatty tissues such as fat depots and the skin. White phosphorus was identified in fatty tissues of one eagle and in one herring gull egg, thus providing direct evidence of absorption of P-4 by predators. C1 USA, CORPS ENGINEERS, COLD REG RES & ENGN LAB, HANOVER, NH 03755 USA. PLYMOUTH STATE COLL, DEPT NAT SCI, PLYMOUTH, NH 03264 USA. COLBY SAWYER COLL, DEPT NAT SCI, NEW LONDON, NH 03257 USA. NR 22 TC 4 Z9 4 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD OCT PY 1994 VL 13 IS 10 BP 1613 EP 1618 DI 10.1897/1552-8618(1994)13[1613:PODPBW]2.0.CO;2 PG 6 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA PH803 UT WOS:A1994PH80300010 ER PT J AU BANTLE, JA BURTON, DT DAWSON, DA DUMONT, JN FINCH, RA FORT, DJ LINDER, G RAYBURN, JR BUCHWALTER, D GAUDETHULL, AM MAURICE, MA TURLEY, SD AF BANTLE, JA BURTON, DT DAWSON, DA DUMONT, JN FINCH, RA FORT, DJ LINDER, G RAYBURN, JR BUCHWALTER, D GAUDETHULL, AM MAURICE, MA TURLEY, SD TI FETAX INTERLABORATORY VALIDATION-STUDY - PHASE-II TESTING SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE FETAX; XENOPUS; TERATOGEN; INTERLABORATORY VALIDATION; DEVELOPMENTAL TOXICITY ID EFFLUENT TOXICITY TESTS AB The Frog Embryo Teratogenesis Assay-Xenopus (FETAX) is a 96-h whole embryo developmental toxicity screening assay that can be used in ecotoxicology and in detecting mammalian developmental toxicants when an in vitro metabolic activation system is employed. A standardized American Society for Testing and Materials (ASTM) guide for the conduct of FETAX has been published along with a companion atlas that helps in embryo staging and identifying malformations. As part of the ASTM process, an interlaboratory validation study was undertaken to evaluate the repeatability and reliability of FETAX. Six different laboratories participated in the study. Each laboratory utilized one technician with the exception of one laboratory, which utilized two independent technicians. In Phase I, FETAX proved to be more repeatable and reliable than many other bioassays. However, some excessive variation was observed in a few laboratories. Some of this variation may have been due to an initial lack of experience with the assay by some technicians. Phase II, which is reported here, showed far less intralaboratory and interlaboratory variability than did Phase I. Nonteratogens such as saccharin and sodium cyclamate showed the most consistent results, whereas more variability was observed for the teratogens caffeine and 5-fluorouracil. Interlaboratory coefficient of variation values for all FETAX end points ranged from 7.3 to 54.7%. The minimum concentration to inhibit growth proved to be the most variable end point for three of the four test chemicals, whereas the LC50 and EC50 (malformation) proved to be less variable. C1 WYE,CTR RES & EDUC,QUEENSTOWN,MD 21658. ASHLAND UNIV,DEPT BIOL & TOXICOL,ASHLAND,OH 44805. OAK RIDGE NATL LAB,DEPT QUAL,OAK RIDGE,TN 37830. STOVER BIOMETR LABS INC,STILLWATER,OK 74076. MANTECH ENVIRONM TECHNOL INC,ENVIRONM RES LAB,CORVALLIS,OR 97333. USA,BIOMED RES & DEV LAB,FT DETRICK,MD 21702. RP BANTLE, JA (reprint author), OKLAHOMA STATE UNIV,DEPT ZOOL,STILLWATER,OK 74078, USA. NR 14 TC 39 Z9 43 U1 1 U2 4 PU SETAC PRESS PI PENSACOLA PA 1010 NORTH 12TH AVE, PENSACOLA, FL 32501-3370 SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD OCT PY 1994 VL 13 IS 10 BP 1629 EP 1637 DI 10.1897/1552-8618(1994)13[1629:FIVSPI]2.0.CO;2 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA PH803 UT WOS:A1994PH80300012 ER PT J AU PANDOLF, KB AF PANDOLF, KB TI HEAT TOLERANCE AND AGING SO EXPERIMENTAL AGING RESEARCH LA English DT Article ID THERMOREGULATORY RESPONSES; DRY-HEAT; AGE; EXERCISE; FLOW; WORK; MEN AB Work-heat tolerance has been reported to be generally lower in middle-aged and elderly men and women than in younger men and women. Some authors have suggested that physically fit older men have fewer decrements in performance during work-heat stress than do less fit men of the same age. However, none of the studies matched older and younger individuals on any pertinent physiological or morphological variables. Recently, four different researchers have reported results of studies in which men or women differed in average age by 25 to 36 years but were matched for body weight, surface area, surface area:body weight ratio, percentage of body fat, and maximal aerobic power. Evidence from three of these studies indicated little impairment of the thermoregulatory system during acute work-heat stress or heat acclimation in these men and women, at least through the seventh decade of life. One of the four studies did indicate higher core temperatures and lower sweating rates in middle-aged women than in younger women after heat acclimation; however, the length of time the heat could be tolerated did not differ between these matched groups. These observations generally support the importance of aerobic fitness and other morphological factors to middle-aged and elderly individuals working or performing recreational activities in hot environments. RP PANDOLF, KB (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 17 TC 4 Z9 4 U1 0 U2 2 PU TAYLOR & FRANCIS PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 0361-073X J9 EXP AGING RES JI Exp. Aging Res. PD OCT-DEC PY 1994 VL 20 IS 4 BP 275 EP 284 DI 10.1080/03610739408253977 PG 10 WC Geriatrics & Gerontology; Psychology SC Geriatrics & Gerontology; Psychology GA PL973 UT WOS:A1994PL97300006 PM 7843214 ER PT J AU WEITZEL, MH HUDAK, JL BECKER, HA WALLER, PR STUIFBERGEN, AK AF WEITZEL, MH HUDAK, JL BECKER, HA WALLER, PR STUIFBERGEN, AK TI AN EXPLORATORY ANALYSIS OF HEALTH PROMOTION BELIEFS AND BEHAVIORS AMONG WHITE, HISPANIC, AND BLACK-MALES SO FAMILY & COMMUNITY HEALTH LA English DT Article DE CULTURAL DIVERSITY; ETHNIC MINORITIES; HEALTH BEHAVIORS; HEALTH BELIEFS; HEALTH PROMOTION; WELLNESS ID PREVENTION AB Secondary analyses were conducted to determine if there are differences in health beliefs and behaviors among three ethnic groups. Responses from 1,033 men on the Multidimensional Health Locus of Control (MHLC) and the Health Promoting Lifestyle Profile (HPLP) instruments were analyzed using one-way analyses of covariance. Significant differences were found only in the powerful others MHLC subscale and in the nutrition HPLP subscale. However, patterns in this exploratory study suggested that Hispanic and black participants' beliefs may be different. The implication for researchers and practitioners is that the common practice of assuming that minority groups share similar health-related beliefs should be reexamined. C1 USA,WASHINGTON,DC 20310. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP WEITZEL, MH (reprint author), UNIV TEXAS,SCH NURSING,CTR HLTH CARE RES & EVALUAT,AUSTIN,TX, USA. NR 24 TC 12 Z9 12 U1 0 U2 0 PU ASPEN PUBL INC PI FREDERICK PA 7201 MCKINNEY CIRCLE, FREDERICK, MD 21701 SN 0160-6379 J9 FAM COMMUNITY HEALTH JI Fam. Community Health PD OCT PY 1994 VL 17 IS 3 BP 23 EP 34 PG 12 WC Family Studies; Public, Environmental & Occupational Health SC Family Studies; Public, Environmental & Occupational Health GA QD378 UT WOS:A1994QD37800005 ER PT J AU KILKELLY, FX MCHALE, KA AF KILKELLY, FX MCHALE, KA TI ACUTE RUPTURE OF THE PERONEAL LONGUS TENDON IN A RUNNER - A CASE-REPORT AND REVIEW OF THE LITERATURE SO FOOT & ANKLE INTERNATIONAL LA English DT Note AB Traumatic rupture of the peroneal longus tendon is rare and the diagnosis may be difficult. Swelling and tenderness about the lateral aspect of the ankle, increased hindfoot varus, and pain with active eversion are helpful clinical signs. Magnetic resonance imaging may be helpful in making the diagnosis. We present the case of a patient who sustained an acute rupture of the peroneal longus tendon. The tendon was repaired primarily and the patient was able to return to running. A high index of suspicion is required to prevent a delay in the diagnosis and further disability. RP KILKELLY, FX (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 0 TC 13 Z9 13 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1071-1007 J9 FOOT ANKLE INT JI Foot Ankle Int. PD OCT PY 1994 VL 15 IS 10 BP 567 EP 569 PG 3 WC Orthopedics SC Orthopedics GA PN312 UT WOS:A1994PN31200009 PM 7834066 ER PT J AU WOODARD, CL CALAMAIO, CA KAMINSKIS, A ANDERSON, DR HARRIS, LW MARTIN, DG AF WOODARD, CL CALAMAIO, CA KAMINSKIS, A ANDERSON, DR HARRIS, LW MARTIN, DG TI ERYTHROCYTE AND PLASMA CHOLINESTERASE ACTIVITY IN MALE AND FEMALE RHESUS-MONKEYS BEFORE AND AFTER EXPOSURE TO SARIN SO FUNDAMENTAL AND APPLIED TOXICOLOGY LA English DT Article AB The rhesus monkey (Macaca mulatta) has a menstrual cycle similar to the human. Differences in hormone levels have been demonstrated between the sexes and in females during the menstrual cycle but these differences in terms of organophosphorus toxicity have not been explored. Plasma cholinesterase (ChE/BuChE) and erythrocyte (RBC) acetylcholinesterase (AChE) activity were measured before and after exposure to the organophosphorus compound sarin (11 mu g/kg, iv; 0.75 LD50) in six male and six female rhesus monkeys. After baseline measurements were obtained, sarin was administered to atropinized monkeys to determine in vivo differences between the sexes in their response to sarin. With the baseline values, the intraanimal and intragroup BuChE/AChE variations were found to be minimal. Following sarin intoxication and 2-PAM treatment no significant differences were seen between the sexes in the rate of reactivation of BuChE or AChE by 2-PAM. The rate of aging of sarin phosphonylated RBC AChE between the sexes was also similar. De novo regeneration of RBC AChE and plasma BuChE after sarin intoxication was different between the male and female monkeys. The female plasma BuChE recovery rate was 48% slower than the male recovery rate, while the early (first 63 days) RBC AChE recovery rate was 24.5% faster in the females. In conclusion, there probably are not any clinically significant differences between male and female rhesus monkeys acutely intoxicated with sarin. However, on subsequent exposure clinical differences may be observed due to substantial differences in the rate of de novo synthesis of both plasma BuChE and RBC AChE. (C) 1994 Society of Toxicology. C1 USN,MED RES UNIT,FPO,AE 09835. USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. RP WOODARD, CL (reprint author), USA,MED RES & DEV COMMAND,FT DETRICK,MD 21702, USA. NR 6 TC 10 Z9 10 U1 0 U2 3 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0272-0590 J9 FUND APPL TOXICOL JI Fundam. Appl. Toxicol. PD OCT PY 1994 VL 23 IS 3 BP 342 EP 347 DI 10.1006/faat.1994.1114 PG 6 WC Toxicology SC Toxicology GA PL450 UT WOS:A1994PL45000003 PM 7835534 ER PT J AU ANGUEIRA, CE KADAKIA, SC AF ANGUEIRA, CE KADAKIA, SC TI EFFECTS OF LARGE-VOLUME PARACENTESIS ON PULMONARY-FUNCTION IN PATIENTS WITH TENSE CIRRHOTIC ASCITES SO HEPATOLOGY LA English DT Article ID THERAPEUTIC PARACENTESIS; INTRAVENOUS ALBUMIN; LIVER-CIRRHOSIS; SAFE AB Large-volume paracentesis is an accepted therapeutic modality for the treatment of tense ascites in patients with cirrhosis. Whereas the effects of large-volume paracentesis on the cardiovascular system have been studied in great detail, the effects of tense ascites and large-volume paracentesis on the respiratory system have undergone only limited evaluation. Most patients report symptomatic improvement in breathing after large-volume paracentesis. The aim of our study was to prospectively evaluate the effects of large-volume paracentesis on the pulmonary function of patients with tense ascites. Nine patients with alcoholic cirrhosis and tense ascites underwent large-volume paracentesis (mean, 3,500 ml of ascites removed) followed by intravenous albumin infusion (10 gm/L ascites removed). Pulmonary function tests were performed just before and 2 hr after large-volume paracentesis. The functional residual capacity increased from 2.46 +/- 0.92 to 2.99 +/- 0.97L (p = 0.01) and total lung capacity from 5.08 +/- 1.18 to 5.72 +/- 1.32 L (p = 0.03). The forced vital capacity, expiratory reserve volume and residual volume also increased but were not statistically significant (p = 0.07 for all). We noted no significant improvement in forced expiratory volume in 1 sec, forced expiratory effort 25% to 75%, vital capacity or diffusion capacity, There was marked symptomatic improvement in all patients. We conclude that large-volume paracentesis improves measured lung volumes within hours in patients with tense ascites. C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,GI ENDOSCOPY UNIT,FT SAM HOUSTON,TX 78234. UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78234. NR 19 TC 33 Z9 34 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 1994 VL 20 IS 4 BP 825 EP 828 DI 10.1002/hep.1840200409 PN 1 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA PJ592 UT WOS:A1994PJ59200008 PM 7927222 ER PT J AU SHERMAN, KE SJOGREN, MH CREAGER, RL FREEMAN, S OBRIEN, J ROOT, S DAVIS, D AF SHERMAN, KE SJOGREN, MH CREAGER, RL FREEMAN, S OBRIEN, J ROOT, S DAVIS, D TI HEPATITIS-C RNA RESPONSE TO COMBINED THERAPY WITH THYMOSIN ALPHA-1 AND INTERFERON SO HEPATOLOGY LA English DT Meeting Abstract C1 FITZSIMONS ARMY MED CTR,AURORA,CO 80045. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 5 Z9 5 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 1994 VL 20 IS 4 BP A207 EP A207 PN 2 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA PM556 UT WOS:A1994PM55600442 ER PT J AU LEMLEY, PV AMANATIDES, P WRIGHT, DC AF LEMLEY, PV AMANATIDES, P WRIGHT, DC TI IDENTIFICATION AND CHARACTERIZATION OF A MONOCLONAL-ANTIBODY THAT NEUTRALIZES RICIN TOXICITY IN-VITRO AND IN-VIVO SO HYBRIDOMA LA English DT Article ID IMMUNOTOXINS; CELLS; LINES; MICE AB We wanted to identify and characterize MAbs with specificity for the toxic lectin ricin, which could serve as detection reagents in elucidating mechanisms and tissue distribution. Neutralizing MAbs could be developed into immunotherapeutics to reverse clinical intoxications from immunotoxin or to counteract the use of ricin as a terrorist or biological warfare weapon. Two hybridomas, UNIVAX 70 and 138, producing MAbs against ricin were identified by Western blot strip analysis. The antibodies were IgG(1) and were specific for the ricin A chain with no ricin B chain cross-reactivity. The MAbs neutralized ricin in vitro in an EL-4 mouse leukemia cell assay and in an in vivo mouse model. The two antibodies recognized the same epitope or overlapping epitopes, based on a competition with one another. All further characterization proceeded on the assumption that they were the same. The MAb UNIVAX 70/138 was characterized in vivo by titrating it against an 18 mu g/kg (>six LD(50)) i.v. challenge and by titrating the i.v. toxin challenge against a constant dose of 100 mu g of passive antibody per mouse. A 4:1 molar ratio of MAb to ricin led to neutralization of greater than or equal to 90 % of the toxin in vitro. The MAb recognized ricin toroid prepared by formaldehyde treatment and after conjugation of low molecular weight haptens (based on ELISA) equally as well as it recognized ricin and ricin A chain. The affinity and specificity of UNIVAX 70/138 give it excellent reagent potential, and the toxin-neutralizing capacity makes it at least a log and a half better than the next best candidate immunotherapeutic. C1 UNIVAX BIOL INC,ROCKVILLE,MD 20853. RP LEMLEY, PV (reprint author), USA,MED RES INST INFECT DIS,DIV TOXICOL,FT DETRICK,FREDERICK,MD 21702, USA. NR 11 TC 62 Z9 63 U1 0 U2 1 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0272-457X J9 HYBRIDOMA JI Hybridoma PD OCT PY 1994 VL 13 IS 5 BP 417 EP 421 DI 10.1089/hyb.1994.13.417 PG 5 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Immunology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Immunology GA PP892 UT WOS:A1994PP89200011 PM 7860097 ER PT J AU LEMLEY, PV AF LEMLEY, PV TI UNIVAX-70/138, ANTI-RICIN SO HYBRIDOMA LA English DT Note RP LEMLEY, PV (reprint author), USA,MED RES INST INFECT DIS,DIV TOXICOL,FREDERICK,MD 21702, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0272-457X J9 HYBRIDOMA JI Hybridoma PD OCT PY 1994 VL 13 IS 5 BP 442 EP 442 PG 1 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Immunology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Immunology GA PP892 UT WOS:A1994PP89200016 ER PT J AU WOOLARD, DL TIAN, H LITTLEJOHN, MA KIM, KW AF WOOLARD, DL TIAN, H LITTLEJOHN, MA KIM, KW TI THE IMPLEMENTATION OF PHYSICAL BOUNDARY-CONDITIONS IN THE MONTE-CARLO SIMULATION OF ELECTRON DEVICES SO IEEE TRANSACTIONS ON COMPUTER-AIDED DESIGN OF INTEGRATED CIRCUITS AND SYSTEMS LA English DT Article ID TRANSPORT; MODEL AB This paper investigates the problem of specifying and implementing physical boundary conditions for the Monte Carlo (MC) simulation of electron dynamics in semiconductor devices. The goal of this work is to establish an accurate and efficient ohmic boundary condition scheme for use in characterizing realistic device structures. In this work, three distinct physical models for specifying the boundary electrons at the ideal ohmic contacts of an N+ - N - N+ GaAs Ballistic diode structure are investigated. This study demonstrates that a displaced Maxwellian scheme, which allows for an electron ensemble with momentum space displacement and random spread, presents definite computational advantages when one is interested in resolving asymmetries in the electron distribution function throughout the semiconductor device structure. C1 N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695. RP WOOLARD, DL (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 19 TC 3 Z9 3 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0278-0070 J9 IEEE T COMPUT AID D JI IEEE Trans. Comput-Aided Des. Integr. Circuits Syst. PD OCT PY 1994 VL 13 IS 10 BP 1241 EP 1246 DI 10.1109/43.317467 PG 6 WC Computer Science, Hardware & Architecture; Computer Science, Interdisciplinary Applications; Engineering, Electrical & Electronic SC Computer Science; Engineering GA PG045 UT WOS:A1994PG04500005 ER PT J AU WARD, AL TAN, RJ KAUL, R AF WARD, AL TAN, RJ KAUL, R TI SPIKE LEAKAGE OF THIN SI PIN LIMITERS SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article AB Thin PIN diode limiters (10 mu m or less) are used to protect sensitive microwave components from fast-risetime microwave pulses having energies exceeding 1 to 10 mu J. This paper analyzes and experimentally confirms the performance of these PIN limiters. It is shown that spike leakage is a transit-time effect that is controlled by the mobility of the carriers. A p-type background I-region should yield less spike leakage energy for a given thickness. It is proposed that the hysteresis effect observed when limiters are operated under cw conditions is due to space charge effects and stored charges remaining after the reverse-biased half cycle. Detailed agreement between the measured and calculated device voltage waveforms requires accurate modeling of the circuit parasitics because of the high rate-of-change currents arising from avalanching. RP WARD, AL (reprint author), USA,RES LAB,RF EFFECTS & HARDENING TECHNOL BRANCH,ADELPHI,MD 20783, USA. NR 21 TC 14 Z9 16 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD OCT PY 1994 VL 42 IS 10 BP 1879 EP 1885 DI 10.1109/22.320768 PG 7 WC Engineering, Electrical & Electronic SC Engineering GA PL265 UT WOS:A1994PL26500006 ER PT J AU SOLN, J AF SOLN, J TI HELICAL CERENKOV EFFECT, A NOVEL RADIATION SOURCE SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article AB The observability of the helical Cerenkov effect as a novel radiation source is discussed. Depending on the value of the index of refraction of the medium, the strength of the uniform magnetic field, and the electron beam energy, helical Cerenkov radiation can occur in the same spectral regions as the ordinary Cerenkov effect, that is, from microwave to visible wavelengths. From the kinematics point of view, I argue that for a microwave wavelength of 10(-1) cm this effect should be observable in a medium with an index of refraction of 1.4, with a beam energy of 3 MeV, and a uniform magnetic field of 4 T. On the specific level, however, for the sake of simplicity, I discuss the observability of this effect for visible light with the central wavelength of 5 x 10(-5) cm which can be achieved with 2 MeV in beam energy, silica aerogel as a medium (with an index of refraction of 1.075), and uniform magnetic fields from 5 to 10 T. For a 10-T magnetic field, I calculate that in the visible region of 250 to 750 nm an electron will produce a photon per 10 cm of traveled length. As to the stimulated helical Cerenkov emission, I estimate that respectable gains are possible even if the beam passes close to the dielectric rather than through it. In addition to being potentially a new radiation source, the helical Cerenkov effect could possibly be used as a detector of radiation by energetic electrons that are trapped in a medium by strong magnetic fields. RP SOLN, J (reprint author), USA,RES LAB,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 17 TC 1 Z9 1 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0093-3813 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD OCT PY 1994 VL 22 IS 5 BP 526 EP 529 DI 10.1109/27.338263 PG 4 WC Physics, Fluids & Plasmas SC Physics GA PT931 UT WOS:A1994PT93100006 ER PT J AU MAIN, W CARMEL, Y OGURA, K WEAVER, J NUSINOVICH, GS KOBAYASHI, S TATE, JP RODGERS, J BROMBORSKY, A WATANABE, S AMIN, MR MINAMI, K DESTLER, WW GRANATSTEIN, VL AF MAIN, W CARMEL, Y OGURA, K WEAVER, J NUSINOVICH, GS KOBAYASHI, S TATE, JP RODGERS, J BROMBORSKY, A WATANABE, S AMIN, MR MINAMI, K DESTLER, WW GRANATSTEIN, VL TI ELECTROMAGNETIC PROPERTIES OF OPEN AND CLOSED OVERMODED SLOW-WAVE RESONATORS FOR INTERACTION WITH RELATIVISTIC ELECTRON-BEAMS SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article ID OSCILLATORS; GENERATION AB Specific slow wave structures are needed in order to produce coherent Cherenkov radiation in overmoded relativistic generators. The electromagnetic characteristics of such slow wave, resonant, finite length structures commonly used in relativistic backward wave oscillators have been studied both experimentally and theoretically. In experiments, perturbation techniques were used to study both the fundamental and higher order symmetric transverse magnetic (TM) modes. Finite length effects lead to end reflections and quantization of the wave number. The effects of end reflections in open slow wave structures were found from the spectral broadening of the discrete resonances of the different axial modes. The measured axial and radial field distributions are in excellent agreement with the results of a 2-D code developed for the calculation of the fields in these structures. C1 USA,RES LABS,ADELPHI,MD. UNIV MARYLAND,DEPT PHYS,COLLEGE PK,MD 20742. NIIGATA UNIV,GRAD SCH SCI & TECHNOL,DEPT ELECT & ELECTR ENGN,NIIGATA,JAPAN. NIIGATA UNIV,DEPT ELECT ENGN,NIIGATA,JAPAN. UNIV MARYLAND,INST PLASMA RES,DEPT ELECT ENGN,COLLEGE PK,MD 20742. RP MAIN, W (reprint author), ACCURAY INC,SANTA CLARA,CA, USA. NR 29 TC 42 Z9 46 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0093-3813 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD OCT PY 1994 VL 22 IS 5 BP 566 EP 577 DI 10.1109/27.338269 PG 12 WC Physics, Fluids & Plasmas SC Physics GA PT931 UT WOS:A1994PT93100012 ER PT J AU SADLER, BM GIANNAKIS, GB LII, KS AF SADLER, BM GIANNAKIS, GB LII, KS TI ESTIMATION AND DETECTION IN NON-GAUSSIAN NOISE USING HIGHER-ORDER STATISTICS SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article ID GAUSSIAN AUTOREGRESSIVE PROCESSES; IDENTIFICATION; BISPECTRUM; CUMULANT; SYSTEMS; SIGNAL AB One of the primary applications of higher order statistics has been for detection and estimation of nonGaussian signals in Gaussian noise of unknown covariance. This is motivated by the fact that higher order cumulants of Gaussian processes vanish. In the present work we study the opposite problem, namely, detection and estimation in nonGaussian noise. We estimate cumulants of nonGaussian processes in the presence of unknown deterministic and/or Gaussian signals, which allows either parametric or nonparametric estimation of the covariance of the nonGaussian process via its cumulants. This in turn motivates a study of detection in colored nonGaussian noise. Our approach is to augment existing second-order detection methods using cumulants. We propose solutions for detection of deterministic signals based on matched filters and the generalized likelihood ratio test which incorporate cumulants, where the resulting solutions are valid under either detection hypothesis. This allows for single record detection and obviates the need for noise-only training records. The problem of estimating signal strength in the presence of nonGaussian noise of unknown covariance is also considered, and a cumulant-based solution is proposed which uses a single data record. Examples are used throughout to illustrate our proposed methods. C1 UNIV VIRGINIA,DEPT ELECT ENGN,CHARLOTTESVILLE,VA 22903. UNIV CALIF RIVERSIDE,DEPT STAT,RIVERSIDE,CA 92502. RP SADLER, BM (reprint author), USA,RES LAB,ADELPHI,MD 20783, USA. NR 38 TC 49 Z9 54 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 1053-587X J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD OCT PY 1994 VL 42 IS 10 BP 2729 EP 2741 DI 10.1109/78.324738 PG 13 WC Engineering, Electrical & Electronic SC Engineering GA PL442 UT WOS:A1994PL44200017 ER PT J AU HOOVER, DL FRIEDLANDER, AM ROGERS, LC YOON, IK WARREN, RL CROSS, AS AF HOOVER, DL FRIEDLANDER, AM ROGERS, LC YOON, IK WARREN, RL CROSS, AS TI ANTHRAX EDEMA TOXIN DIFFERENTIALLY REGULATES LIPOPOLYSACCHARIDE-INDUCED MONOCYTE PRODUCTION OF TUMOR-NECROSIS-FACTOR-ALPHA AND INTERLEUKIN-6 BY INCREASING INTRACELLULAR CYCLIC-AMP SO INFECTION AND IMMUNITY LA English DT Article ID MESSENGER-RNA EXPRESSION; GENE-RELATED PEPTIDE; ADENYLATE-CYCLASE; BACILLUS-ANTHRACIS; LETHAL TOXIN; PERITONEAL-MACROPHAGES; PROTECTIVE ANTIGEN; IFN-GAMMA; CELLS; PROTEIN AB Bacillus anthracis exotoxins mediate most of the symptomatology of severe anthra?r. In addition to a clinical syndrome reminiscent of septic shock, which may be mediated by cytokines produced by macrophages stimulated with lethal toxin, infected patients show profound edema at sites of infection. Edema is mediated by edema toxin (ET), which comprises of a binding molecule, protective antigen, and an active moiety, edema factor, which possesses intrinsic adenylyl cyclase activity. Intracellular cyclic AMP (cAMP) regulates the production of several cytokines that modulate edema formation and play important roles in host defense against invading bacteria. To determine whether ET enhanced the accumulation of cAMP in monocytes and thereby influenced cytokine production, we cultured human monocytes with endotoxin (lipopolysaccharide [LPS]) and dilutions of ET and determined the levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) in culture supernatant fluids. We further estimated cytokine-specific mRNA accumulation in monocytes by reverse transcription PCR and examined intracellular cAMP concentrations following treatment with ET. ET and LPS each induced monocytes to secrete comparable amounts of IL-6. ET did not inhibit and in most experiments modestly enhanced LPS-induced IL-6 production. In contrast to this stimulatory effect on IL-6 production, ET induced little or no TNF-alpha production. Moreover, ET profoundly inhibited LPS-induced TNF-alpha synthesis. These regulatory phenomena were also observed at the mRNA level in association with dose-related enhancement of intracellular cAMP in ET-treated monocytes. Monocytes treated with dibutyryl cAMP, an active analog of cAMP, produced cytokines in a pattern identical to that of cells treated with ET. ?he disruption of cytokine networks as a consequence of unregulated, ET-induced cAMP accumulation in human monocytes may impair cellular antimicrobial responses and contribute to clinical signs and symptoms. C1 USA, MED RES INST INFECT DIS, DIV BACTERIOL, FREDERICK, MD 21701 USA. RP WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, DEPT BACTERIAL DIS, WASHINGTON, DC 20307 USA. NR 45 TC 104 Z9 106 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 EI 1098-5522 J9 INFECT IMMUN JI Infect. Immun. PD OCT PY 1994 VL 62 IS 10 BP 4432 EP 4439 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA PH298 UT WOS:A1994PH29800046 PM 7927706 ER PT J AU SZU, SC TAYLOR, DN TROFA, AC CLEMENTS, JD SHILOACH, J SADOFF, JC BRYLA, DA ROBBINS, JB AF SZU, SC TAYLOR, DN TROFA, AC CLEMENTS, JD SHILOACH, J SADOFF, JC BRYLA, DA ROBBINS, JB TI LABORATORY AND PRELIMINARY CLINICAL CHARACTERIZATION OF VI CAPSULAR POLYSACCHARIDE-PROTEIN CONJUGATE VACCINES SO INFECTION AND IMMUNITY LA English DT Article ID INFLUENZAE TYPE-B; TYPHOID-FEVER; SALMONELLA-TYPHI; ESCHERICHIA-COLI; CHOLERA-TOXIN; BONE-MARROW; CHILDREN; CULTURES; IMMUNOGENICITY; PREVENTION AB To improve its immunogenicity for children and adults and to make it suitable for routine immunization of infants against typhoid fever, the capsular polysaccharide of Salmonella typhi (Vi) was bound to the B subunit of the heat-labile toxin (LT-B) of Escherichia coli or the recombinant exoprotein ii (rEPA) of Pseudomonas aeruginosa. The conjugates elicited higher levels of antibodies (micrograms per milliliter of serum) in mice and in guinea pigs than did Vi and, unlike Vi alone, elicited booster antibody responses in both species. In adult volunteers, Vi-LT-B and Vi-rEPA respectively, elicited higher levels of antibodies than Vi alone after the first injection (4.74 versus 1.77 and 4.91 versus 1.77; P < 0.005) and 26 weeks later (2.32 and 2.69 versus 0.54; P < 0.04); a second injection of the conjugates did not elicit a booster response of Vi antibodies. None of the 51 vaccinees had fever or significant local reactions. Vi-rEPA elicited slightly higher levels of Vi antibodies than did Vi-LT-B at II intervals after injection, but these differences were not significant. Each conjugate elicited antibodies to its carrier protein. The antibody responses elicited in adults by Vi bound to LT-B and rEPA are similar to those of other polysaccharide-protein conjugates. These conjugates promise to be an improved Vi vaccine. Studies of Vi conjugates with adults and infants in areas where typhoid is endemic are planned. C1 NIDDKD,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. TULANE UNIV,MED CTR,DEPT MICROBIOL & IMMUNOL,NEW ORLEANS,LA 70112. RP SZU, SC (reprint author), NICHHD,BLDG 6,RM 145,BETHESDA,MD 20892, USA. NR 47 TC 80 Z9 82 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD OCT PY 1994 VL 62 IS 10 BP 4440 EP 4444 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA PH298 UT WOS:A1994PH29800047 PM 7927707 ER PT J AU DOMENICO, P SALO, RJ CROSS, AS CUNHA, BA AF DOMENICO, P SALO, RJ CROSS, AS CUNHA, BA TI POLYSACCHARIDE CAPSULE-MEDIATED RESISTANCE TO OPSONOPHAGOCYTOSIS IN KLEBSIELLA PNEUMONIAS SO INFECTION AND IMMUNITY LA English DT Article ID O-ANTIGEN; SALICYLATE AB The polysaccharide capsule of Klebsiella pneumoniae is an important virulence factor that confers resistance to phagocytosis. The treatment of encapsulated bacteria with salicylate to inhibit capsule expression was found to enhance the phagocytosis of encapsulated bacteria by human neutrophils only in the presence of cell surface-specific antibodies. Both type-specific rabbit antisera and anticapsular human hyperimmune globulin were employed as opsonins. Salicylate significantly enhanced phagocytosis with homologous, but not heterologous, whole-cell antisera. Antisera, diluted 1:40, no longer opsonized fully encapsulated bacteria but promoted the uptake of multiple salicylate-treated bacteria in >90% of neutrophils. Salicylate (0.25 to 1.0 mM) also enhanced opsonization with globulin against homologous bacteria. Higher salicylate levels (1 to 2.5 mM) enhanced the opsonization of heterologous serotypes with human globulin. The nature of antibody attachment to encapsulated bacteria was determined by immunofluorescence. Even after the addition of purified capsular polysaccharide to prevent phagocytosis, K-specific antibodies attached in large amounts to bacteria. K-specific antibodies reacted with antigens throughout the capsule and showed a predilection for a denser inner layer of the capsule, indicating that many of the K-specific antibodies may be masked underneath the capsule surface. K-specific antibodies can also be rendered nonfunctional by soluble, cell-free capsular antigen. In culture, large quantities of soluble capsular polysaccharide extrude from bacteria after overnight growth. The reduction in capsule expression caused by salicylate largely affected the soluble, cell-free fraction. Purified capsular polysaccharide was shown to retard the opsonophagocytosis of salicylate-treated bacteria in a concentration-dependent manner. However, extensive washing of encapsulated bacteria to remove loosely attached capsular material did not significantly enhance opsonophagocytosis. In conclusion, cell-free capsule and cell-associated capsule are antiphagocytic; both act to neutralize K-specific antibodies by binding or concealment. Salicylate-mediated inhibition of capsule expression, particularly of the cell-free fraction, improved K-specific opsonization dramatically. C1 SUNY STONY BROOK,SCH MED,STONY BROOK,NY 11794. NASSAU CTY MED CTR,DEPT PEDIAT,E MEADOW,NY 11554. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP DOMENICO, P (reprint author), WINTHROP UNIV HOSP,DIV INFECT DIS,MINEOLA,NY 11501, USA. NR 26 TC 40 Z9 42 U1 0 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD OCT PY 1994 VL 62 IS 10 BP 4495 EP 4499 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA PH298 UT WOS:A1994PH29800054 PM 7927714 ER PT J AU CHEN, JYJ QIAO, YR KOMISAR, JL BAZE, WB HSU, IC TSENG, JN AF CHEN, JYJ QIAO, YR KOMISAR, JL BAZE, WB HSU, IC TSENG, JN TI INCREASED SUSCEPTIBILITY TO STAPHYLOCOCCAL-ENTEROTOXIN-B INTOXICATION IN MICE PRIMED WITH ACTINOMYCIN-D SO INFECTION AND IMMUNITY LA English DT Note ID TUMOR-NECROSIS-FACTOR; HUMAN T-CELLS; SUPERANTIGENS; RESPONSES; TOXICITY; TOXINS AB Mice (BALB/cJ, C3H/HeN, and C3H/HeJ) primed with actinomycin D became highly susceptible to lethal Intoxication with staphylococcal enterotoxin B (SEB). The mice underwent toxicosis and toxic shock and died. Actinomycin D-primed C3H/HeN and C3H/HeJ mice showed equal sensitivity to SEB, suggesting that bacterial Lipopolysaccharide derived from gram-negative bacteria in the gut may not be an important cofactor in intoxication. In a time course study of the illness, prominent pathological changes characterized by blood congestion and thickening of alveolar septa were seen Tn the lung, while blood congestion, inflammation, epithelial cell flattening, and villous blunting were seen in the small intestine. In lymphoid tissues, such as the spleen, congestion, inflammation, and lymphoid cell depletion were the major reactions. The pathological features of them!ce had many similarities to those of rhesus monkeys intoxicated with intravenous SEB. The actinomycin D-primed C3H/HeJ mice are thus an ideal mouse model for studying SEB toxicosis and toxic shock. C1 WALTER REED ARMY MED CTR, DEPT EXPTL PATHOL, DIV PATHOL, WASHINGTON, DC 20307 USA. UNIV MARYLAND, SCH MED, DEPT PATHOL, BALTIMORE, MD 21201 USA. NR 28 TC 29 Z9 32 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 EI 1098-5522 J9 INFECT IMMUN JI Infect. Immun. PD OCT PY 1994 VL 62 IS 10 BP 4626 EP 4631 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA PH298 UT WOS:A1994PH29800072 PM 7927730 ER PT J AU WAIN, HJ WOLLAMN, K SANDMAN, L RADCLIFFE, E AF WAIN, HJ WOLLAMN, K SANDMAN, L RADCLIFFE, E TI A COMPARISON OF THE HYPNOTIC CAPACITY OF PSYCHIATRIC OUTPATIENTS AND PSYCHIATRIC-CONSULTATION LIAISON PATIENTS SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL HYPNOSIS LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 SN 0020-7144 J9 INT J CLIN EXP HYP JI Int. J. Clin. Exp. Hypn. PD OCT PY 1994 VL 42 IS 4 BP 471 EP 472 PG 2 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA PH040 UT WOS:A1994PH04000030 ER PT J AU WOODWARD, RL GOOCH, WA ODONNELL, RG PERCIBALLI, WJ BAXTER, BJ PATTIE, SD AF WOODWARD, RL GOOCH, WA ODONNELL, RG PERCIBALLI, WJ BAXTER, BJ PATTIE, SD TI A STUDY OF FRAGMENTATION IN THE BALLISTIC IMPACT OF CERAMICS SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article ID PENETRATION AB Experiments in which both confined and unconfined ceramic targets are perforated by pointed and blunt projectiles are described, and a correlation is established between increased degree of fragmentation and reduced ceramic toughness. Front confinement of the ceramic results in greater overall fragmentation, however fewer, very fine fragments are produced for confined targets compared to unconfined targets. By attributing the fine fragments principally to crushing ahead of the impacting projectile, and coarse fragmentation to the interaction of stress relief waves, the effects of confinement can be qualitatively explained in terms of a simple model for loading and stress relief during perforation. The use of blunt projectiles increases the degree of fragmentation in those cases where the ceramic strength itself is insufficient to fracture the tip on impact. Measurements of fractured ceramic surface area and calculations of fracture work demonstrate that very little of the projectile kinetic energy is consumed in creating new ceramic fracture surface, and it is shown that a high proportion of the projectile impact kinetic energy is redistributed to residual kinetic energy of ejected ceramic debris. For cases where the projectile does not deform during penetration it is possible to derive a value for the average pressure resisting the penetrator. The ballistic efficiency of the ceramic increases with hardness for the lower strength ceramics, however, for the hard ceramics, where the principal influence of the ceramic is to destroy the projectile nose and create an inefficient penetrator, it is found in these tests that the residual penetration depths are similar, and ballistic efficiency is then unrelated to ceramic strength. C1 USA,RES LAB,ABERDEEN PROVING GROUND,MD 21010. CSIRO,DIV MAT SCI,CLAYTON,VIC 3168,AUSTRALIA. RP WOODWARD, RL (reprint author), DSTO MAT RES LAB,POB 50,ASCOT,VIC 3032,AUSTRALIA. NR 23 TC 66 Z9 75 U1 1 U2 19 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD OCT PY 1994 VL 15 IS 5 BP 605 EP 618 DI 10.1016/0734-743X(94)90122-2 PG 14 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA NZ772 UT WOS:A1994NZ77200002 ER PT J AU RAFTENBERG, MN AF RAFTENBERG, MN TI LAGRANGIAN HYDROCODE SIMULATIONS OF ROLLED-HOMOGENEOUS-ARMOR PLATE PERFORATION BY A SHAPED CHARGE JET SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article AB Three experiments are performed in which a 13-mm-thick rolled-homogeneous-armor plate is perforated by the leading particle of a copper jet produced by firing a shaped charge warhead at long standoff These experiments are modelled using the 1986 version of EPIC-2, to which two failure models have been added to simulate effects of tensile voids and shear bands. The tensile void model employs a negative pressure cutoff onset criterion, followed by instantaneous reduction to zero of all deviatoric stresses and hydrostatic tensile stress within the finite element. The shear banding model uses the Zener-Hollomon onset criterion, followed by reduction of deviatoric stresses in proportion to the difference between the element's current level of equivalent plastic strain and that corresponding to onset. The two failure models together with the code's slideline erosion algorithm allow for good agreement with experiment in terms of the final hole radius averaged over the target plate's thickness, the time required for complete hole formation, and the net mass lost by the plate. Mesh sensitivity studies are conducted to validate partially the procedure. RP RAFTENBERG, MN (reprint author), USA,RES LAB,WEAP TECHNOL DIRECTORATE,ABERDEEN PROVING GROUND,MD 21010, USA. NR 19 TC 4 Z9 4 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD OCT PY 1994 VL 15 IS 5 BP 619 EP 643 DI 10.1016/0734-743X(94)90133-6 PG 25 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA NZ772 UT WOS:A1994NZ77200003 ER PT J AU RAO, DVGLN ARANDA, FJ REMY, DE ROACH, JF AF RAO, DVGLN ARANDA, FJ REMY, DE ROACH, JF TI 3RD-ORDER NONLINEAR-OPTICAL INTERACTIONS IN TETRABENZPORPHYRINS SO INTERNATIONAL JOURNAL OF NONLINEAR OPTICAL PHYSICS LA English DT Article ID ABSORPTION; BISTABILITY; FILMS AB Third-order nonlinear optical susceptibility chi(3) was measured for a variety of tetra-benzporphyrin compounds in solution in tetrahydrofuran at 532 nm using the technique of degenerate four-wave mixing. High values in the range 10(-9) to 10(-8) esu are observed. The dominant contribution comes from the imaginary part as a result of excited state absorption. Measurements were also made on thin films, deposited by the Langmuir-Blodgett technique, for one of the compounds. Mirrorless all-optical bistability induced by reverse saturable absorption was observed. These materials are good candidates for some applications in photonics technology. C1 USA,NATICK RES,DEV CTR & ENGN,NATICK,MA 01760. RP RAO, DVGLN (reprint author), UNIV MASSACHUSETTS,DEPT PHYS,BOSTON,MA 02125, USA. RI Rao, Devulapalli/L-8863-2015 NR 36 TC 17 Z9 17 U1 0 U2 1 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA JOURNAL DEPT PO BOX 128 FARRER ROAD, SINGAPORE 9128, SINGAPORE SN 0218-1991 J9 INT J NONLINEAR OPT PD OCT PY 1994 VL 3 IS 4 BP 511 EP 529 DI 10.1142/S0218199194000304 PG 19 WC Optics; Physics, Applied SC Optics; Physics GA PV204 UT WOS:A1994PV20400008 ER PT J AU BISELLI, R LOOMIS, LD DELBONO, V BURKE, DS REDFIELD, RR BIRX, DL AF BISELLI, R LOOMIS, LD DELBONO, V BURKE, DS REDFIELD, RR BIRX, DL TI IMMUNIZATION OF HIV-INFECTED PATIENTS WITH RGP160 - MODULATION OF ANTI-RGP120 ANTIBODY SPECTROTYPE SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE HUMAN IMMUNODEFICIENCY VIRUS; ENVELOPE GLYCOPROTEIN; VACCINE THERAPY; ISOELECTRIC FOCUSING ID HUMAN-IMMUNODEFICIENCY-VIRUS; HUMAN MONOCLONAL-ANTIBODIES; B-CELL ACTIVATION; ENVELOPE GLYCOPROTEIN; IMMUNE-RESPONSE; HOMOSEXUAL MEN; IMMUNOLOGICAL ABNORMALITIES; RECOMBINANT GP160; KAPOSIS SARCOMA; SYNDROME AIDS AB HIV-1 infection results in progressive failure of the immune system with decline in the number and/or function of B-cell clones originally recruited in specific humoral responses. Spectrotypic analysis, done by isoelectric focusing and reverse blotting (IEF-RB), is one technique for evaluating the activity and the number of specific B-cell clones and is adaptable to the direct measurement of antibodies to conformationally intact epitopes. The anti-HIV-1 (IIIB) rgp120 spectrotype was measured in 30 early-stage HIV-infected volunteers undergoing vaccine therapy with recombinant gp160 (rgp160). Twenty-five of the patients displayed a clear oligoclonal banding pattern; seven (28%) showed the same pattern in all samples, while 18 (72%) showed changes. Ten of the latter had an increase in band intensity over the course of immunization, and eight had an increase in both band intensity and number of bands. In contrast, serum samples from eight patients receiving placebo (alum) showed no changes over a comparable period. These findings suggest that vaccine therapy with rgp160 may be able to expand the anti-HIV-1 (LAI) gp120 B-cell clone pool in some HIV-infected patients as well as increase antibody synthesis by established B-cell clones recruited during natural infection. These data provide further evidence that postinfection vaccination may provide an alternative strategy in the treatment of chronic viral diseases. C1 HENRY M JACKSON FDN,HIV LAB,ROCKVILLE,MD 20850. WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD. WALTER REED ARMY INST RES,DEPT RETROVIRAL RES,ROCKVILLE,MD. OI /0000-0002-5704-8094 NR 57 TC 17 Z9 17 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD OCT PY 1994 VL 7 IS 10 BP 1016 EP 1024 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA PH776 UT WOS:A1994PH77600003 PM 8083819 ER PT J AU DANDEKAR, DP ABBATE, A FRANKEL, J AF DANDEKAR, DP ABBATE, A FRANKEL, J TI EQUATION OF STATE OF ALUMINUM NITRIDE AND ITS SHOCK RESPONSE SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID PRESSURE PHASE-TRANSITION; ROCK-SALT-TYPE; WAVE; ALN AB Equation of state of aluminum nitride (AIN) is determined from the ultrasonic wave velocity measurements of longitudinal and shear modes to 0.7 GPa. The equation of state obtained from the ultrasonic data is used in conjunction with the shock Hugoniot data on AIN to estimate its strength under plane shock wave compression. Further, a better understanding of the existing shock Hugoniot data above its transition stress from wurtzite to rock salt structure is realized through a comparison with the static high-pressure investigations pertaining to this phase transition in AlN. C1 USA,ARMAMENT MUNIT & CHEM COMMAND,BENET WEAPONS LAB,WATERVLIET,NY 12189. RP DANDEKAR, DP (reprint author), USA,RES LAB,MAT DIRECTORATE,WATERTOWN,MA 02172, USA. NR 27 TC 20 Z9 20 U1 0 U2 5 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD OCT 1 PY 1994 VL 76 IS 7 BP 4077 EP 4085 DI 10.1063/1.357357 PG 9 WC Physics, Applied SC Physics GA PK458 UT WOS:A1994PK45800019 ER PT J AU DEHLAWI, MS ELDEFRAWI, AT ELDEFRAWI, ME ANIS, NA VALDES, JJ AF DEHLAWI, MS ELDEFRAWI, AT ELDEFRAWI, ME ANIS, NA VALDES, JJ TI CHOLINE DERIVATIVES AND SODIUM-FLUORIDE PROTECT ACETYLCHOLINESTERASE AGAINST IRREVERSIBLE INHIBITION AND AGING BY DFP AND PARAOXON SO JOURNAL OF BIOCHEMICAL TOXICOLOGY LA English DT Article DE ACETYLCHOLINESTERASE PROTECTANTS; BIOSENSOR ACETYLCHOLINESTERASE; ORGANOPHOSPHATE INHIBITORS; ACETYLCHOLINESTERASE AGING; PARAOXON/ACETYLCHOLINESTERASE INHIBITION; NAF ACETYLCHOLINESTERASE PROTECTION; DFP ACETYLCHOLINESTERASE PROTECTION ID PRETREATMENT; PROPHYLAXIS; BIOSENSOR; ANIMALS AB A light addressable potentiometric sensor was used to measure acetylcholinesterase (AChE) activity in order to evaluate the protective effects of quaternary compounds and NaF against enzyme phosphorylation and aging by two organophosphates. The use of the immobilized AChE made possible the quick removal of reagents (i.e., organophosphate, 2-pralidoxime, and protectant), thereby permitting accurate determination of AChE activity before and after phosphorylation and aging. Paraoxon was 15-fold more potent in inhibiting AChE than DFP, while the percent aging following phosphorylation by diisopropylfluorophosphate (DFF) was much higher. Sodium fluoride (NaF), the most effective protectant against phosphorylation and aging, and the quaternary ammonium compounds reduced significantly AChE inhibition by DFP and paraoxon, to similar degrees. Even though the percent AChE activity that was lost to aging was reduced by these agents, aging as a percent of phosphorylated AChE was not reduced. Thus, their major effect was in reducing the percent AChE phosphorylation, which consequently resulted in reduction of total aged AChE. The finding that quaternary ammonium compounds protect against phosphorylation is consonant with the proposed presence of the active site of AChE in an aromatic gorge. C1 USA,EDGEWOOD RD & E CTR,DIV BIOTECHNOL,ABERDEEN PROVING GROUND,MD 21010. KING ABDULAZIZ UNIV,COLL SCI,DEPT BIOL SCI,JEDDAH,SAUDI ARABIA. NR 20 TC 14 Z9 15 U1 2 U2 3 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0887-2082 J9 J BIOCHEM TOXICOL JI J. Biochem. Toxicol. PD OCT PY 1994 VL 9 IS 5 BP 261 EP 268 DI 10.1002/jbt.2570090506 PG 8 WC Toxicology SC Toxicology GA PP045 UT WOS:A1994PP04500005 PM 7853361 ER PT J AU MARDEN, LJ HOLLINGER, JO CHAUDHARI, A TUREK, T SCHAUB, RG RON, E AF MARDEN, LJ HOLLINGER, JO CHAUDHARI, A TUREK, T SCHAUB, RG RON, E TI RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2 IS SUPERIOR TO DEMINERALIZED BONE-MATRIX IN REPAIRING CRANIOTOMY DEFECTS IN RATS SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH LA English DT Article ID BOVINE OSTEOGENIC PROTEIN; INDUCTIVE PROTEIN; DIFFERENTIATION INVITRO; EXTRACELLULAR-MATRIX; OSTEOBLASTIC CELLS; BETA FAMILY; PURIFICATION; CHROMATOGRAPHY; COLLAGEN; IMPLANTS AB The purpose of this study was to measure bone-regenerative effects of recombinant human bone morphogenetic protein-2 (rhBMP-2) in rat calvarial critical-size defects (CSDs). CSDs (8 mm in diameter) were treated with either: 1) 2.2 mu g rhBMP-2 combined with insoluble collagenous bone matrix (ICBM), 2) 6.5 mu g 8 rhBMP-2 plus ICBM, 3) ICBM alone, or 4) demineralized bone matrix (DBM), for 7, 14, or 21 days. Multiple linear regression showed that rhBMP-2 had a significant time- and dose-dependent effect on bone regeneration (P < .05). After 7 days, new calcifying cartilage and remineralizing ICBM, with an occasional zone of new woven bone, was evident in defects treated with rhBMP-2/ICBM. By 14 days, both doses of rhBMP-2 reconstituted with ICBM had induced more bone formation than ICBM alone or DBM, and 6.5 mu g was superior to 2.2 mu g, There was no evidence of adverse cellular response. This study shows for the first time that rhBMP-2 could restore osseous form to a calvarial defect. In addition, osteoregeneration was accelerated by the higher dose of rhBMP-2. (C) 1994 John Wiley & Sons, Inc. C1 USA,WALTER REED ARMY MED CTR,INST DENT RES,WASHINGTON,DC 20307. GENET INST INC,ANDOVER,MA 01810. NR 42 TC 126 Z9 128 U1 0 U2 4 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0021-9304 J9 J BIOMED MATER RES JI J. Biomed. Mater. Res. PD OCT PY 1994 VL 28 IS 10 BP 1127 EP 1138 DI 10.1002/jbm.820281003 PG 12 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA PJ304 UT WOS:A1994PJ30400002 PM 7829543 ER PT J AU KENLEY, R MARDEN, L TUREK, T JIN, L RON, E HOLLINGER, JO AF KENLEY, R MARDEN, L TUREK, T JIN, L RON, E HOLLINGER, JO TI OSSEOUS REGENERATION IN THE RAT CALVARIUM USING NOVEL DELIVERY SYSTEMS FOR RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2 (RHBMP-2) SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH LA English DT Article ID FRACTURE FIXATION IMPLANTS; OSTEOGENIN; ALGINATE AB In the current investigation, we report osseous regeneration in critical-size rat calvarial defects using recombinant human bone morphogenetic protein-2 (rhBMP-2) and novel delivery systems based on biomaterials. The novel systems combine rhBMP-2 with dry powder microparticles of poly(D,L-lactide-co-glycolide) (PLGA). The mixture of rhBMP-2 with PLGA microparticles is added to an aqueous solution of biopolymer to yield a semisolid paste. The biopolymers tested include autologous blood clot, hydroxypropyl methylcellulose, and sodium alginate cross-linked with calcium ion. Insoluble collageneous bone matrix was also studied as a control. Test articles were made at 0-, 10-, and 30-mu g doses of rhBMP-2 and implanted in 8-mm-diameter rat carvarial defects (which will not heal if left untreated). The animals were examined 21 days after implantation by radiography, radiomorphometry, histology, and histomorphometry. All tested materials containing rhBMP-2 restored radiopacity and normal contouring to the calvarial defects. Samples without added rhBMP-2 yielded only soft tissue within the defects. Histology showed restoration of inner and outer bone tables plus marrow constituents. The PLGA microparticles were significantly resorbed at the 21-day time point. Although small differences between delivery systems were evident at 0- and 10-mu g rhBMP-2 doses, all test articles performed essentially equivalently at the 30-mu g dose. Thus, novel delivery systems for rhBMP-2 offer the promise of combining the intrinsic bioactivity of the osteoinductive protein with pharmaceutically acceptable biomaterials. (C) 1994 John Wiley & Sons, Inc. C1 USA,WALTER REED ARMY MED CTR,INST DENT RES,WASHINGTON,DC 20307. GENET INST INC,ANDOVER,MA 01810. FOCAL INTERVENT THERAPIES INC,CAMBRIDGE,MA 02139. OREGON HLTH SCI UNIV,PORTLAND,OR 97201. RP KENLEY, R (reprint author), AMYLIN PHARMACEUT INC,9250 TRADE PL,SAN DIEGO,CA 92196, USA. NR 46 TC 148 Z9 153 U1 0 U2 3 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0021-9304 J9 J BIOMED MATER RES JI J. Biomed. Mater. Res. PD OCT PY 1994 VL 28 IS 10 BP 1139 EP 1147 DI 10.1002/jbm.820281004 PG 9 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA PJ304 UT WOS:A1994PJ30400003 PM 7829544 ER PT J AU MURRAY, RN PARKER, A KADAKIA, SC AYALA, E MARTINEZ, EM AF MURRAY, RN PARKER, A KADAKIA, SC AYALA, E MARTINEZ, EM TI CYTOMEGALOVIRUS IN UPPER GASTROINTESTINAL ULCERS SO JOURNAL OF CLINICAL GASTROENTEROLOGY LA English DT Article DE CYTOMEGALOVIRUS; ULCERS, UPPER GASTROINTESTINAL; ASPIRIN; NONSTEROIDAL ANTIINFLAMMATORY DRUGS ID VIRUS INFECTION; NORMAL HOST; GASTRIC-ULCERS; AIDS; ESOPHAGITIS; TRANSPLANTATION; MONONUCLEOSIS; ULCERATION; PATIENT; TRACT AB Cytomegalovirus (CMV), an important cause of severe infections in immunocompromised patients, can cause ulcerations anywhere in the gastrointestinal tract, most commonly stomach and colon. Only a few cases of CMV inclusions in gastrointestinal ulcers have been reported in normal hosts. We undertook a prospective study of the incidence of CMV in gastroduodenal ulcerations in immunocompetent patients. Thirty-eight patients who were referred for evaluation of dyspepsia, hematemesis, melena, guaiac-positive stools, or iron deficiency anemia and who had gastric or duodenal ulcerations without stigmata of recent hemorrhage or visible vessel were enrolled in the study. Six biopsies obtained from the ulcer base and margin were submitted for histologic examination, shell-vial viral cultures, and monoclonal antibody testing. Thirty-two patients had gastric ulcer and six had duodenal bulbar ulcer ranging in size from 8 to 20 mm in diameter. Forty-four percent of patients had been taking aspirin or nonsteroidal antiinflammatory drugs (NSAIDs) within 10 days of ulcer discovery. Evaluation of all biopsies in 38 patients failed to document any evidence of CMV by light microscopy, viral cultures, or monoclonal antibody testing. CMV infection is uncommon in the gastrointestinal tract of immunocompetent patients with gastroduodenal ulcers. Even within areas of previous mucosal injury induced by nonsteroidal drugs, no evidence of CMV ''superinfection'' was found. We conclude that CMV infection is not a significant factor in routine peptic or NSAID-induced ulcer disease, and the discovery of CMV inclusions in gastroduodenal ulcerations should lead to a search for an immunocompromised state. C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234. NR 33 TC 13 Z9 14 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0192-0790 J9 J CLIN GASTROENTEROL JI J. Clin. Gastroenterol. PD OCT PY 1994 VL 19 IS 3 BP 198 EP 201 DI 10.1097/00004836-199410000-00005 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA PH781 UT WOS:A1994PH78100004 PM 7806828 ER PT J AU CHENEY, CP MURPHY, JR WONG, RKH AF CHENEY, CP MURPHY, JR WONG, RKH TI COLONOSCOPIC DISSOLUTION OF A BAROLITH SO JOURNAL OF CLINICAL GASTROENTEROLOGY LA English DT Note ID BOWEL OBSTRUCTION; BARIUM RP CHENEY, CP (reprint author), WALTER REED ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,WASHINGTON,DC 20307, USA. NR 13 TC 4 Z9 4 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0192-0790 J9 J CLIN GASTROENTEROL JI J. Clin. Gastroenterol. PD OCT PY 1994 VL 19 IS 3 BP 265 EP 266 DI 10.1097/00004836-199410000-00021 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA PH781 UT WOS:A1994PH78100021 PM 7806843 ER PT J AU LYLE, KH DOWELL, EH AF LYLE, KH DOWELL, EH TI ACOUSTIC RADIATION DAMPING OF FLAT RECTANGULAR-PLATES SUBJECTED TO SUBSONIC FLOWS .1. ISOTROPIC SO JOURNAL OF FLUIDS AND STRUCTURES LA English DT Article ID MODEL; SOUND AB The acoustic radiation damping for various plates and semi-infinite strips subjected to a uniform, subsonic and steady flow has been predicted. The predictions are based on the linear vibration of a flat plate. The fluid loading is characterized as the perturbation pressure derived from the linearized Bernoulli and continuity equations. Parameters varied in the analysis include Mach number, mode number and plate size, aspect ratio and mass. Results show that the fluid loading can significantly affect realistic plate responses. In addition, acoustic radiation damping values can be greater than or equal to the structural component of the modal critical damping ratio (assumed as 0.01) for the higher subsonic Mach numbers. C1 DUKE UNIV,SCH ENGN,DURHAM,NC 27708. RP LYLE, KH (reprint author), NASA,LANGLEY RES CTR,USA,VEHICLE STRUCT DIRECTORATE,HAMPTON,VA 23665, USA. NR 25 TC 9 Z9 9 U1 0 U2 6 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0889-9746 J9 J FLUID STRUCT JI J. Fluids Struct. PD OCT PY 1994 VL 8 IS 7 BP 711 EP 735 DI 10.1016/S0889-9746(94)90180-5 PG 25 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA PN332 UT WOS:A1994PN33200003 ER PT J AU LYLE, KH DOWELL, EH AF LYLE, KH DOWELL, EH TI ACOUSTIC RADIATION DAMPING OF FLAT RECTANGULAR-PLATES SUBJECTED TO SUBSONIC FLOWS .2. COMPOSITE SO JOURNAL OF FLUIDS AND STRUCTURES LA English DT Article AB The acoustic radiation damping for various laminated composite and aluminum plates subjected to a uniform, subsonic, and steady flow has been predicted. The predictions are based on the linear equations of motion of a flat plate. The fluid loading is characterized as the perturbation pressure derived from the linearized Bernoulli and continuity equations of fluid mechanics. Parameters varied in the analysis include Mach number and plate material properties and ply lay-up. Results show that the fluid loading can significantly affect realistic plate responses. Universal curves are presented where the acoustic radiation damping normalized by the mass ratio is a smooth function of the reduced frequency. A separate curve was required for each Mach number and plate aspect ratio. Generally, graphite/epoxy and carbon/carbon plates have higher acoustic radiation damping values than similar aluminum plates, except near plate divergence conditions resulting from aeroelastic instability. In addition, acoustic radiation damping values can be greater than or equal to the structural damping ratio component (assumed as 0.01) for the higher Mach numbers. C1 DUKE UNIV,SCH ENGN,DURHAM,NC 27708. RP LYLE, KH (reprint author), NASA,LANGLEY RES CTR,USA,VEHICLE STRUCT DIRECTORATE,HAMPTON,VA 23665, USA. NR 14 TC 1 Z9 1 U1 1 U2 4 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0889-9746 J9 J FLUID STRUCT JI J. Fluids Struct. PD OCT PY 1994 VL 8 IS 7 BP 737 EP 746 DI 10.1016/S0889-9746(94)90200-3 PG 10 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA PN332 UT WOS:A1994PN33200004 ER PT J AU BOLTON, JM DURNFORD, DS CHARLIE, WA AF BOLTON, JM DURNFORD, DS CHARLIE, WA TI ONE-DIMENSIONAL SHOCK AND QUASI-STATIC LIQUEFACTION OF SILT AND SAND SO JOURNAL OF GEOTECHNICAL ENGINEERING-ASCE LA English DT Article AB This paper summarizes the results of undrained quasi-static and shock compression tests performed on confined specimens of saturated Bonny Silt, Monterey No. 0/30 sand, and a mixture of the two soids. The tests evaluated pore pressure response and liquefaction potential of sand, silt and silty-sand subjected to high intensity compressive loading. The quasi-static tests consisted of load cycles of increasing magnitude and the shock tests consisted of millisecond compressive wave loadings. Shock and quasi-static induced excess pore pressures were approximately equal when the sand was subjected to equal peak strains. The silt and the mixture exhibited significantly higher increases in excess pore pressure under quasi-static loading than under shock loading for the same peak strain. The pore-pressure ratio of the three soil types increased with increasing peak strain, with decreasing effective stress, and with increasing void ratio. C1 COLORADO STATE UNIV,DEPT CIVIL ENGN,FT COLLINS,CO 80523. COLORADO STATE UNIV,DEPT AGR & CHEM ENGN,FT COLLINS,CO 80523. RP BOLTON, JM (reprint author), USA,CORPS ENGINEERS,CENPP PE DC,POB 2946,PORTLAND,OR 97208, USA. NR 16 TC 9 Z9 9 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9410 J9 J GEOTECH ENG-ASCE JI J. Geotech. Eng.-ASCE PD OCT PY 1994 VL 120 IS 10 BP 1874 EP 1889 DI 10.1061/(ASCE)0733-9410(1994)120:10(1874) PG 16 WC Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA PH615 UT WOS:A1994PH61500012 ER PT J AU CROSS, A ARTENSTEIN, A QUE, J FREDEKING, T FURER, E SADOFF, JC CRYZ, SJ AF CROSS, A ARTENSTEIN, A QUE, J FREDEKING, T FURER, E SADOFF, JC CRYZ, SJ TI SAFETY AND IMMUNOGENICITY OF A POLYVALENT ESCHERICHIA-COLI VACCINE IN HUMAN VOLUNTEERS SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID GRAM-NEGATIVE BACTEREMIA; O-POLYSACCHARIDE-TOXIN; INFLUENZAE TYPE-B; CONJUGATE VACCINES; BACTERIAL POLYSACCHARIDE; HAEMOPHILUS-INFLUENZAE; ANTIBODY-RESPONSES; SUPPRESSION; EPISODES; ANTIGENS AB Since a limited number of O serogroups account for nearly 70% of bacteremic and meningitic Escherichia coli isolates, a polyvalent vaccine was made by conjugating a Pseudomonas aeruginosa exotoxin A carrier protein to the O polysaccharide of 12 serogroups off. coli (O1, O2, O3, O6-O8, O12, O15, O16, O18, O25, O75). No serious reactions occurred in 88 vaccinees. Fourfold or greater increases in ELISA antibody levels over baseline were greatest (> 60% of vaccinees) for O1, O2, O6-O8 and O15; intermediate (similar to 50%) for O18 and O75, and poorest (greater than or equal to 45%) for O4, O12, O16, and O25. Responses with functionally active opsonophagocytic antibody generally paralleled ELISA antibody responses. With the availability of a safe, immunogenic E. coli vaccine, active and passive immunization strategies merit further development as adjunctive treatment for E. coli bacteremia and neonatal meningitis. C1 ANTIBODY SYST,BEDFORD,TX. SWISS SERUM & VACCINE INST,CH-3001 BERN,SWITZERLAND. RP CROSS, A (reprint author), WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307, USA. NR 32 TC 14 Z9 14 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD OCT PY 1994 VL 170 IS 4 BP 834 EP 840 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA PJ694 UT WOS:A1994PJ69400012 PM 7523536 ER PT J AU BHATNAGAR, N GETACHEW, E STRALEY, S WILLIAMS, J MELTZER, M FORTIER, A AF BHATNAGAR, N GETACHEW, E STRALEY, S WILLIAMS, J MELTZER, M FORTIER, A TI REDUCED VIRULENCE OF RIFAMPICIN-RESISTANT MUTANTS OF FRANCISELLA-TULARENSIS SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID RNA-POLYMERASE; IDENTIFICATION; INFECTION; IMMUNITY; PROTEINS; MACROPHAGES; EXPRESSION; STRAIN; CELLS; GENE AB Rifampicin-resistant mutants of a live vaccine strain (LVS) of Francisella tularensis were produced and screened for virulence in mice; 4 avirulent clones with intraperitoneal (ip) LD(50)s > 10(6) cfu, compared with 10(2) cfu for LVS, were characterized. Growth characteristics at 37 degrees C, surface envelope proteins, and lipopolysaccharide profiles of resistant mutants were identical to those of LVS. Polymerase activity of the mutants was more resistant than the enzyme from LVS to the inhibitory action of rifampicin. Growth rates for mutants and LVS were similar during the first 5 h at 42 degrees C, but viability of the mutants decreased to < 0.01% at 24 h. LVS and mutants differed in their ability to grow in vitro in host macrophages: LVS increased 580-fold over 72 h; mutants increased 33-fold. After ip inoculation of the organisms into mice, increasing numbers of LVS from peritoneal cells were isolated; mutants decreased over 4 days. C1 ENTRE MED INC,ROCKVILLE,MD 20850. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. UNIV KENTUCKY,MED CTR,DEPT IMMUNOL & MICROBIOL,LEXINGTON,KY. KAISER PERMANENTE,FOOD & DRUG ADM,DERMATOL SERV,VACCINES BRANCH,ROCKVILLE,MD. NR 38 TC 25 Z9 25 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD OCT PY 1994 VL 170 IS 4 BP 841 EP 847 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA PJ694 UT WOS:A1994PJ69400013 PM 7930725 ER PT J AU BURKOT, TR PIESMAN, J WIRTZ, RA AF BURKOT, TR PIESMAN, J WIRTZ, RA TI QUANTITATION OF THE BORRELIA-BURGDORFERI OUTER SURFACE PROTEIN-A IN IXODES-SCAPULARIS - FLUCTUATIONS DURING THE TICK LIFE-CYCLE, DOUBLING TIMES, AND LOSS WHILE FEEDING SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID LYME-DISEASE SPIROCHETE; INBRED STRAINS; DAMMINI ACARI; SP-NOV; MICE; TRANSMISSION; IXODIDAE; AGENT; OSPA; INOCULATION AB The presence of outer surface protein A (OspA) as a marker for Borrelia burgdorferi in Ixodes scapularis ticks was monitored with an OspA antigen-capture ELISA. The OspA ELISA, with a sensitivity of 30 spirochetes (8 fg), was not affected by the presence of either recently blood-fed or flat tick homogenates. Median spirochete equivalent levels as high as 16,000 in larvae, 55,000 in attached nymphs, and 10,000 in unfed adults were observed. Estimates of OspA doubling times ranged from a maximum of 140 h in larvae to as short as 17.5 h during nymphal attachment to the host. Spirochete equivalents in nymphs fell by 3 X 10(4) spirochete equivalents (54% of total OspA) in the last 12 h of attachment to mice but rose after detachment. Each OspA-positive I. scapularis nymph, regardless of spirochete equivalent density or length of attachment, successfully transmitted B. burgdorferi to a mouse. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. RP BURKOT, TR (reprint author), CTR DIS CONTROL & PREVENT,DIV VECTOR BORNE INFECT DIS,MED ENTOMOL ECOL BRANCH,FT COLLINS,CO 80522, USA. RI Burkot, Thomas/C-6838-2013 NR 32 TC 56 Z9 56 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD OCT PY 1994 VL 170 IS 4 BP 883 EP 889 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA PJ694 UT WOS:A1994PJ69400020 PM 7930731 ER PT J AU KRAKAUER, T AF KRAKAUER, T TI COSTIMULATORY RECEPTORS FOR THE SUPERANTIGEN STAPHYLOCOCCAL-ENTEROTOXIN-B ON HUMAN VASCULAR ENDOTHELIAL-CELLS AND T-CELLS SO JOURNAL OF LEUKOCYTE BIOLOGY LA English DT Article DE SUPERANTIGEN; COSTIMULATORY RECEPTORS; ENDOTHELIAL CELLS; T CELLS; CYTOKINES ID TUMOR-NECROSIS-FACTOR; MICROBIAL SUPERANTIGENS; GAMMA-INTERFERON; ACCESSORY CELL; FACTOR-ALPHA; ACTIVATION; ADHESION; ICAM-1; EXPRESSION; CD28 AB Cell-surface molecules on human vascular endothelial cells (ECs) and T lymphocytes that mediate staphylococcal enterotoxin B (SEB)-induced T cell proliferation and cytokine production were investigated. Expression of HLA-DR and intercellular adhesion molecule 1 (ICAM-1) on EC was induced by interferon-gamma (IFN-gamma). IFN-gamma-treated ECs bound SEB effectively and stimulated T cells to proliferate and secrete tumor necrosis factor alpha (TNF-alpha) and IFN-gamma. SEB-induced T cell proliferation was inhibited by monoclonal antibodies to CD2, CD11a, CD28, ICAM-1, and endothelial leukocyte adhesion molecule (ELAM). These antibodies also blocked production of the proinflammatory mediators, TNP-alpha and IFN-gamma, in SEB-stimulated T cell-EC cocultures. These results suggest that the surface molecules, CD11a: CD18/ICAM-1, CD2, CD28, and ELAM, are all important costimulatory receptors for T cell activation by superantigens with the EC as the antigen-presenting cell. Thus, like conventional antigens, multiple stimulatory signals from the interactions of these receptors are required for superantigen-induced immune responses with ECs and T cells. Reducing proinflammatory mediators such as TNP-alpha and IFN-gamma by these antibodies in SEB-induced T cell responses may be a useful therapeutic strategy for circumventing SEB toxicity and pathogenesis. RP KRAKAUER, T (reprint author), USA,MED RES INST INFECT DIS,DIV APPL RES,BLDG 1425,FREDERICK,MD 21702, USA. NR 30 TC 26 Z9 28 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0741-5400 J9 J LEUKOCYTE BIOL JI J. Leukoc. Biol. PD OCT PY 1994 VL 56 IS 4 BP 458 EP 463 PG 6 WC Cell Biology; Hematology; Immunology SC Cell Biology; Hematology; Immunology GA PK360 UT WOS:A1994PK36000005 PM 7930941 ER PT J AU SCHOLTEN, RJPM KUIPERS, B VALKENBURG, HA DANKERT, J ZOLLINGER, WD POOLMAN, JT AF SCHOLTEN, RJPM KUIPERS, B VALKENBURG, HA DANKERT, J ZOLLINGER, WD POOLMAN, JT TI LIPO-OLIGOSACCHARIDE IMMUNOTYPING OF NEISSERIA-MENINGITIDIS BY A WHOLE-CELL ELISA WITH MONOCLONAL-ANTIBODIES SO JOURNAL OF MEDICAL MICROBIOLOGY LA English DT Article ID OUTER-MEMBRANE PROTEINS; MENINGOCOCCAL LIPOPOLYSACCHARIDES; SEROGROUP-A; LIPOOLIGOSACCHARIDES; SEROTYPES; EPITOPES; ANTIGENS; INHIBITION; EPIDEMIC; DISEASE AB To assess the applicability of a whole-cell ELISA (WCE) with monoclonal antibodies (MAbs) for lipo-oligosaccharide (LOS) immunotyping of Neisseria meningitidis, 675 meningococcal isolates obtained in 1989 and 1990 in the Netherlands and 57 isolates collected in 1974, of which the immunotype had been determined previously by microprecipitation, were analysed. Despite the lack of specific MAbs for L2 and L4, an algorithm was developed for the assignment of immunotypes on the basis of the reaction patterns of the reference strains and these isolates to a combination of 14 MAbs. The immunotypes found by WCE were in accordance with those obtained by microprecipitation and the results from WCE were reproducible. The distribution of immunotypes among isolates of the various serogroups in the Netherlands in 1989-1990 is presented. Based on the reaction patterns of the isolates, two main categories of related immunotypes could be distinguished among isolates of serogroups B and C: L2/L4 and L3/L1/L8. Some isolates of the latter category were of one immunotype, but many isolates expressed one or two additional immunotypes, either strongly or weakly, indicating that the differences in this category are quantitative rather than qualitative. The results of this study have demonstrated that the WCE method for LOS immunotyping is easily applicable and provides better definition of test strains for invitro bactericidal assays and research into pathogenesis. C1 NATL INST PUBL HLTH & ENVIRONM PROTECT,BACTERIAL VACCINE DEV & PATHOGENESIS RES UNIT,3720 BA BILTHOVEN,NETHERLANDS. UNIV AMSTERDAM,NATL INST PUBL HLTH & ENVIRONM PROTECT,WHO COLLABORATING CTR,AMSTERDAM,NETHERLANDS. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. RP SCHOLTEN, RJPM (reprint author), VRIJE UNIV AMSTERDAM,INST RES EXTRAMURAL MED,AMSTERDAM,NETHERLANDS. NR 29 TC 93 Z9 97 U1 0 U2 0 PU CHAPMAN HALL LTD PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8HN SN 0022-2615 J9 J MED MICROBIOL JI J. Med. Microbiol. PD OCT PY 1994 VL 41 IS 4 BP 236 EP 243 PG 8 WC Microbiology SC Microbiology GA PM994 UT WOS:A1994PM99400005 PM 7523677 ER PT J AU TAYLOR, JC CHRISTENSEN, LC AF TAYLOR, JC CHRISTENSEN, LC TI A CUSTOMIZED MANDREL FOR SIMPLIFYING THE POLISHING OF CRANIAL PROSTHESES SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Note RP TAYLOR, JC (reprint author), WALTER REED ARMY MED CTR,DEPT PROSTHODONT,WASHINGTON,DC 20307, USA. NR 2 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD OCT PY 1994 VL 72 IS 4 BP 450 EP 450 DI 10.1016/0022-3913(94)90570-3 PG 1 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA PJ318 UT WOS:A1994PJ31800019 PM 7990055 ER PT J AU MCCLEAN, MD LEVANDOWSKI, DR CORD, MT AF MCCLEAN, MD LEVANDOWSKI, DR CORD, MT TI INTERSYLLABIC MOVEMENT TIMING IN THE FLUENT SPEECH OF STUTTERERS WITH DIFFERENT DISFLUENCY LEVELS SO JOURNAL OF SPEECH AND HEARING RESEARCH LA English DT Article DE STUTTERING; MOVEMENT TIMING; SPEECH; SPEECH KINEMATICS ID KINEMATIC ANALYSIS; DYNAMICS AB The goal of this study was to identify possible differences in movement timing in the fluent speech of adult stutterers who show varying levels of speech disfluency. Strain gauge recordings of lip and jaw movements and electroglottographic recordings of laryngeal vibration were obtained in 31 subjects as they repeated simple speech utterances. Measures of the duration and variability of intersyllablic articulatory events were analyzed in relation to speech disfluency level and history of speech treatment. As expected, movement durations were longer in subjects who had been through speech treatment. No significant associations were observed between timing durations and disfluency level. However, more disfluent subjects tended to show reduced variability in timing durations, an effect that was independent of speech treatment. This finding is interpreted in relation to previous observations on control systems that show instability and disfunction in association with reduced output variability. When disfluency level was measured during physiologic testing, duration interacted with speech treatment, with more disfluent subjects in the treatment group showing increased durations in their fluent speech. This effect is attributed to volitional control intended to facilitate speech fluency. RP MCCLEAN, MD (reprint author), WALTER REED ARMY MED CTR,CTR AUDIOL & SPEECH,WASHINGTON,DC 20307, USA. NR 21 TC 14 Z9 14 U1 0 U2 1 PU AMER SPEECH-LANGUAGE-HEARING ASSOC PI ROCKVILLE PA 10801 ROCKVILLE PIKE RD, ROCKVILLE, MD 20852-3279 SN 0022-4685 J9 J SPEECH HEAR RES JI J. Speech Hear. Res. PD OCT PY 1994 VL 37 IS 5 BP 1060 EP 1066 PG 7 WC Language & Linguistics; Rehabilitation SC Linguistics; Rehabilitation GA PL224 UT WOS:A1994PL22400010 PM 7823552 ER PT J AU DEWEY, RR REICH, RW SAOUMA, VE AF DEWEY, RR REICH, RW SAOUMA, VE TI UPLIFT MODELING FOR FRACTURE-MECHANICS ANALYSIS OF CONCRETE DAMS SO JOURNAL OF STRUCTURAL ENGINEERING-ASCE LA English DT Article AB The modeling of uplift pressures within a dam, on the foundation on which it was constructed, and on the interface between the dam and foundation is a critical aspect in the analysis of concrete gravity dams. The procedures for modeling uplift pressures are well established for the traditional hand-calculation methods, but this is not the case for finite element (FE) analysis. In this paper, the procedures for including uplift pressures in the hand-calculation methods, as prescribed by various government agencies, are reviewed and compared. Three separate models for including uplift pressures in a FE analysis are proposed. The use of these models is demonstrated in cracked-base analyses of two different dam geometries with identical material properties. A linear elastic fracture mechanics criterion is used to determine the final crack length rather than the strength criterion used in the hand-calculation methods. The results of these analyses are compared with one another and with results published elsewhere for one of the two geometries but with different material properties. C1 FINITE ELEMENT FACTORY,SUNNYVALE,CA 94086. UNIV COLORADO,DEPT CIV ENV & ARCH ENGN,BOULDER,CO 80309. RP DEWEY, RR (reprint author), USA,CORPS ENGRS,PORTLAND,OR 97208, USA. RI Saouma, Victor/G-6191-2014 OI Saouma, Victor/0000-0003-1721-1034 NR 20 TC 7 Z9 7 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9445 J9 J STRUCT ENG-ASCE JI J. Struct. Eng.-ASCE PD OCT PY 1994 VL 120 IS 10 BP 3025 EP 3044 DI 10.1061/(ASCE)0733-9445(1994)120:10(3025) PG 20 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA PH603 UT WOS:A1994PH60300013 ER PT J AU CHOWDHURY, MR AF CHOWDHURY, MR TI NONLINEAR FINITE-ELEMENT ANALYSIS OF RC SLAB BRIDGE - DISCUSSION SO JOURNAL OF STRUCTURAL ENGINEERING-ASCE LA English DT Discussion RP CHOWDHURY, MR (reprint author), USA,ENGN WATERWAYS EXPT STN,STRUCT LAB,VICKSBURG,MS 39180, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9445 J9 J STRUCT ENG-ASCE JI J. Struct. Eng.-ASCE PD OCT PY 1994 VL 120 IS 10 BP 3077 EP 3078 DI 10.1061/(ASCE)0733-9445(1994)120:10(3077) PG 2 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA PH603 UT WOS:A1994PH60300020 ER PT J AU LI, YL WHITE, MJ HWANG, MH AF LI, YL WHITE, MJ HWANG, MH TI GREENS-FUNCTIONS FOR WAVE-PROPAGATION ABOVE AN IMPEDANCE GROUND SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID COMPLEX ERROR FUNCTION; SOUND-PROPAGATION; PLANE AB In this paper, a new method is introduced for attacking the problem of sound propagation above an impedance ground. This new method is based on a technique in which the solution of the Helmholtz equation is expressed as a onefold integral with an integrand that is identified as the solution of the heat conduction equation for an auxiliary problem. The heat conduction equation is solved via the inverse Laplace transform and its solution is substituted back into the original onefold integral. Finally, the new integral solution of the Helmholtz equation is approximated by the modified stationary phase method. Solutions of the Helmholtz equation are given for point and line sources above an impedance ground. The results obtained from these new solutions are compared with results from direct numerical integration of the exact solution. The agreement is excellent. C1 USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61826. RP LI, YL (reprint author), UNIV ILLINOIS,DEPT ELECT & COMP ENGN,WAVE PROPAGAT LAB,1308 W MAIN ST,URBANA,IL 61801, USA. RI White, Michael/B-3612-2009 OI White, Michael/0000-0001-8450-9135 NR 33 TC 5 Z9 5 U1 3 U2 4 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD OCT PY 1994 VL 96 IS 4 BP 2485 EP 2490 DI 10.1121/1.410121 PG 6 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA PL708 UT WOS:A1994PL70800056 ER PT J AU COZZA, SJ EDISON, DL AF COZZA, SJ EDISON, DL TI RISPERIDONE IN ADOLESCENTS SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY LA English DT Letter ID SCHIZOPHRENIA; CLOZAPINE RP COZZA, SJ (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 6 TC 30 Z9 30 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0890-8567 J9 J AM ACAD CHILD PSY JI J. Am. Acad. Child Adolesc. Psychiatr. PD OCT PY 1994 VL 33 IS 8 BP 1211 EP 1211 DI 10.1097/00004583-199410000-00023 PG 1 WC Psychology, Developmental; Pediatrics; Psychiatry SC Psychology; Pediatrics; Psychiatry GA PH203 UT WOS:A1994PH20300025 PM 7527022 ER PT J AU NORTON, SA AF NORTON, SA TI USEFUL PLANTS OF DERMATOLOGY .1. HYDNOCARPUS AND CHAULMOOGRA SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article RP NORTON, SA (reprint author), TRIPLER ARMY MED CTR,DEPT MED,DERMATOL SERV,HONOLULU,HI 96859, USA. NR 20 TC 11 Z9 11 U1 2 U2 3 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD OCT PY 1994 VL 31 IS 4 BP 683 EP 686 PG 4 WC Dermatology SC Dermatology GA PJ914 UT WOS:A1994PJ91400028 PM 8089304 ER PT J AU SINGH, D SINGH, JP MAJUMDAR, S KUPPERMAN, DS COWDIN, E BHATT, RT AF SINGH, D SINGH, JP MAJUMDAR, S KUPPERMAN, DS COWDIN, E BHATT, RT TI EFFECT OF PROCESSING VARIABLES ON INTERFACIAL PROPERTIES OF AN SIC-FIBER-REINFORCED REACTION-BONDED SI3N4 MATRIX COMPOSITE SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID CERAMIC-MATRIX; MECHANICAL-PROPERTIES; PUSHOUT TESTS; GLASS; STRENGTH; ROUGHNESS; BEHAVIOR AB Fiber/matrix interfacial debonding and frictional sliding stresses were evaluated by single-fiber pushout tests on unidirectional continuous silicon-carbide-fiber-reinforced, reaction-bonded silicon nitride matrix composites. The debonding and maximum pushout loads required to overcome interfacial friction were obtained from load-displacement plots of pushout tests. Interfacial debonding and frictional sliding stresses were evaluated for composites with various fiber contents and fiber surface conditions (coated and uncoated), and after matrix densification by hot isostatic pressing (HIPing). For as-fabricated composites, both debonding and frictional sliding stresses decreased with increasing fiber content. The HIPed composites, however, exhibited higher interfacial debonding and frictional sliding stresses than those of the as-fabricated composites. These results were related to variations in axial and transverse residual stresses on fibers in the composites. A shearlag model developed for a partially debonded composite, including full residual stress field, was employed to analyze the nonlinear dependence of maximum pushout load on embedded fiber length for as-fabricated and HIPed composites. Interfacial friction coefficients of 0.1-0.16 fitted the experimental data well. The extremely high debonding stress observed in uncoated fibers is believed to be due to strong chemical bonding between fiber and matrix. C1 NASA,LEWIS RES CTR,USA,PROPULS DIRECTORATE,CLEVELAND,OH 44035. RP SINGH, D (reprint author), ARGONNE NATL LAB,DIV ENERGY TECHNOL,ARGONNE,IL 60439, USA. NR 34 TC 13 Z9 13 U1 0 U2 5 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, PO BOX 6136, WESTERVILLE, OH 43081-6136 SN 0002-7820 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD OCT PY 1994 VL 77 IS 10 BP 2561 EP 2568 DI 10.1111/j.1151-2916.1994.tb04643.x PG 8 WC Materials Science, Ceramics SC Materials Science GA PM483 UT WOS:A1994PM48300010 ER PT J AU MILLER, WB RICKLIN, JC ANDREWS, LC AF MILLER, WB RICKLIN, JC ANDREWS, LC TI EFFECTS OF THE REFRACTIVE-INDEX SPECTRAL MODEL ON THE IRRADIANCE VARIANCE OF A GAUSSIAN-BEAM SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID TURBULENT MEDIA; PROPAGATION AB The normalized irradiance variance of a Gaussian beam in the weak-fluctuation regime is examined numerically with the use of various spectral models for refractive index fluctuations. The Kolmogorov, Tatarskii, and modified von Karman spectral models are chosen as conventional models, while the Hill numerical spectral model and the Andrews analytic approximation to the Hill model are selected to feature the characteristic bump at high wave numbers. The latter two models are known to predict higher scintillation levels than conventional spectral models when the Fresnel zone and the inner scale are of comparable size. Outer scale effects appear minimal near the centerline of the beam but can reduce off-axis scintillation significantly. Inner scale effects are prominent on axis as well as off axis, although they sometimes tend to diminish near the diffractive beam edge. Analytic approximations are developed for the irradiance variance based on the Kolmogorov, modified von Karman, and Andrews spectral models. These analytic expressions are generally in excellent agreement with numerical results. C1 UNIV CENT FLORIDA,DEPT MATH,ORLANDO,FL 32816. UNIV CENT FLORIDA,CTR RES & EDUC OPT & LASERS,ORLANDO,FL 32816. RP MILLER, WB (reprint author), USA,RES LAB,BATTLEFIELD ENVIRONM DIRECTORATE,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 22 TC 66 Z9 71 U1 1 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0740-3232 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD OCT PY 1994 VL 11 IS 10 BP 2719 EP 2726 DI 10.1364/JOSAA.11.002719 PG 8 WC Optics SC Optics GA PH986 UT WOS:A1994PH98600018 ER PT J AU HACKETT, S DUDLEY, D WALKER, J AF HACKETT, S DUDLEY, D WALKER, J TI HETEROGENEITIES, INFORMATION AND CONFLICT-RESOLUTION - EXPERIMENTAL-EVIDENCE ON SHARING CONTRACTS SO JOURNAL OF THEORETICAL POLITICS LA English DT Article DE COMMON-POOL RESOURCES; CONTRACTS; EXPERIMENTAL; HETEROGENEITY ID COMMON-POOL; MODEL AB A growing body of field and experimental literature provides considerable evidence that individuals may adopt self-governing institutions that enable conflict resolution. This paper examines this issue by exploring the role of heterogeneity in individuals' production capabilities and past investments as an obstacle to conflict resolution. Results are presented from two ongoing research programs: (1) individual and group decision making in the context of a commonly held resource that is subtractable in units of appropriation and (2) ex post negotiation of surplus shares in incomplete contracts. Both programs have been designed to investigate conflict resolution when subjects are heterogenous in costly investments they have incurred. C1 US MIL ACAD,DEPT SOCIAL SCI,W POINT,NY 10996. INDIANA UNIV,DEPT ECON,BLOOMINGTON,IN 47405. RP HACKETT, S (reprint author), HUMBOLDT STATE UNIV,SCH BUSINESS & ECON,ARCATA,CA 95521, USA. NR 33 TC 1 Z9 2 U1 5 U2 5 PU SAGE PUBLICATIONS LTD PI LONDON PA 6 BONHILL STREET, LONDON, ENGLAND EC2A 4PU SN 0951-6298 J9 J THEOR POLIT JI J. Theor. Polit. PD OCT PY 1994 VL 6 IS 4 BP 495 EP 525 DI 10.1177/0951692894006004005 PG 31 WC Political Science SC Government & Law GA PQ955 UT WOS:A1994PQ95500005 ER PT J AU KOLKA, MA STEPHENSON, LA GONZALEZ, RR AF KOLKA, MA STEPHENSON, LA GONZALEZ, RR TI THERMOREGULATION IN WOMEN DURING UNCOMPENSABLE HEAT-STRESS SO JOURNAL OF THERMAL BIOLOGY LA English DT Article DE THERMOREGULATION; WOMEN; CLOTHING; HEAT STRESS; SWEATING RATE ID MENSTRUAL-CYCLE; PHYSIOLOGICAL-RESPONSES; BLOOD-FLOW; EXERCISE; ACCLIMATION; MODERATE; MEN AB 1. The purpose of this investigation was to quantify heat exchange in women during exercise under conditions of uncompensable heat stress. The women were studied in the early follicular phase of the menstrual cycle. 2. The average exercise time was 52 +/- 13 minutes, end exercise mean body temperature was 38.4 +/- 0.4 degrees C, and end exercise heart rate was 169 +/- 14 b min(-1) during these follicular phase experiments. 3. Net heat flow (M(sk)) during exercise averaged 193 +/- 30 W m(-2), the change in body temperature was 0.03 +/- 0.01 degrees C min(-1), evaporative heat loss through the clothing (E(cl)) averaged 139 +/- 46 W m(-2), which was 45 +/- 14% of the sweating rate. 4. Women exercising during uncompensable heat stress during the early follicular phase of their menstrual cycles exercised for a similar duration as that predicted for men by our Institute's heat strain model. Currently, we do not generalize these conclusions to all phases of the menstrual cycle. C1 USA,ENVIRONM MED RES INST,DIV BIOMED MODELLING,NATICK,MA 01760. RP KOLKA, MA (reprint author), USA,ENVIRONM MED RES INST,DIV THERMAL PHYSIOL & MED,NATICK,MA 01760, USA. NR 23 TC 16 Z9 16 U1 3 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0306-4565 J9 J THERM BIOL JI J. Therm. Biol. PD OCT PY 1994 VL 19 IS 5 BP 315 EP 320 DI 10.1016/0306-4565(94)90067-1 PG 6 WC Biology; Zoology SC Life Sciences & Biomedicine - Other Topics; Zoology GA PW310 UT WOS:A1994PW31000004 ER PT J AU MILLER, MS AF MILLER, MS TI THERMOPHYSICAL PROPERTIES OF CYCLOTRIMETHYLENETRINITRAMINE SO JOURNAL OF THERMOPHYSICS AND HEAT TRANSFER LA English DT Note RP MILLER, MS (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 5 TC 8 Z9 8 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0887-8722 J9 J THERMOPHYS HEAT TR JI J. Thermophys. Heat Transf. PD OCT-DEC PY 1994 VL 8 IS 4 BP 803 EP 805 DI 10.2514/3.618 PG 3 WC Thermodynamics; Engineering, Mechanical SC Thermodynamics; Engineering GA PL528 UT WOS:A1994PL52800027 ER PT J AU BAIRD, DE OMDAL, DG YUILL, SC HANSEN, MF HASSELL, LH COCKERILL, ML BANKHEAD, RA AF BAIRD, DE OMDAL, DG YUILL, SC HANSEN, MF HASSELL, LH COCKERILL, ML BANKHEAD, RA TI DOPPLER ANALYSIS OF HEMODIALYSIS GRAFTS - RESISTIVE INDEX AS A PREDICTOR OF STENOSIS SO JOURNAL OF ULTRASOUND IN MEDICINE LA English DT Article ID VASCULAR ACCESS COMPLICATIONS; ARTERIOVENOUS-FISTULAS; PATENCY RATES; SONOGRAPHY; DIALYSIS; ANGIOGRAPHY; SHUNTS AB A series of six hemodialysis vascular access patients was evaluated with duplex Doppler sonography and angiography to identify Doppler sonographic parameters that are predictors of venous outflow stenosis. This preliminary series indicates that no venous outflow stenosis was present angiographically when the resistive index gradient across the venous anastomosis is less than or equal to zero and a significant venous outflow stenosis (50 to 100%) was present when the resistive index gradient is 0.15 or greater (P = 0.002, r = 0.963). Doppler acquisition of resistive index gradients across regions of venous outflow is a promising, noninvasive means of rapid radiologic evaluation of hemodialysis graft patients, especially when the need for angiography is equivocal. C1 TRIPLER ARMY MED CTR,DEPT NEPHROL,HONOLULU,HI. RP BAIRD, DE (reprint author), TRIPLER ARMY MED CTR,DEPT RADIOL HSHK DR,HONOLULU,HI 96859, USA. NR 17 TC 9 Z9 9 U1 0 U2 0 PU AMER INST ULTRASOUND MEDICINE PI LAUREL PA SUBSCRIPTION DEPT, 14750 SWEITZER LANE, STE 100, LAUREL, MD 20707-5906 SN 0278-4297 J9 J ULTRAS MED JI J. Ultrasound Med. PD OCT PY 1994 VL 13 IS 10 BP 791 EP 796 PG 6 WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging GA PL205 UT WOS:A1994PL20500010 PM 7823341 ER PT J AU FERNANDEZ, EB SESTERHENN, IA MCCARTHY, WF MOSTOFI, FK MOUL, JW AF FERNANDEZ, EB SESTERHENN, IA MCCARTHY, WF MOSTOFI, FK MOUL, JW TI PROLIFERATING CELL NUCLEAR ANTIGEN EXPRESSION TO PREDICT OCCULT DISEASE IN CLINICAL STAGE-I NONSEMINOMATOUS TESTICULAR GERM-CELL TUMORS SO JOURNAL OF UROLOGY LA English DT Article DE TESTICULAR NEOPLASMS; ANTIGENS, NEOPLASM; CARCINOMA ID DNA-REPLICATION; S-PHASE; CANCER INTERGROUP; EMBEDDED TISSUES; CYCLIN PCNA; CARCINOMA; P53; SUPPRESSOR; TESTIS; HISTOPATHOLOGY AB We analyzed primary tumor tissue from 89 clinical stage I nonseminomatous germ cell testicular tumor patients for proliferating cell nuclear antigen expression and histological features to determine if these elements could distinguish pathological stage I (52 patients) from pathological stage II disease or patients who later had relapse (37). Using a monoclonal antibody (PC10 dagger) developed for use in archival tissue, nuclear proliferating cell nuclear antigen expression was immunohistochemically measured for the overall tumor (total proliferating cell nuclear antigen) and for each neoplastic cell type present. In addition, the primary tumor was examined for the presence of vascular invasion and determination of the percentage of tumor composed of embryonal carcinoma. Univariate logistic regression analysis revealed higher total (p = 0.0001) and higher embryonal carcinoma proliferating cell nuclear antigen expression (p = 0.0437) to be statistically significant risk factors for occult disease, correctly predicting its presence 73% and 61.5% of the time, respectively. More importantly, the presence of vascular invasion and a higher percentage embryonal carcinoma were highly significant risk factors for occult disease and were truly predictive in 80.4% and 77.2% of the cases, respectively. Multivariate logistic regression analysis revealed a combination of vascular invasion and percentage embryonal carcinoma to be the best model to predict occult disease correctly (85.9%). The addition of total or embryonal carcinoma proliferating cell nuclear antigen expression did not improve the clinical use of the model containing vascular invasion and percentage embryonal carcinoma. Although proliferating cell nuclear antigen expression mirrors the biological behavior of clinical stage I nonseminomatous germ cell testicular tumor to some degree, assessment of vascular invasion and percentage embryonal carcinoma has greater clinical use. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,DEPT SURG,UROL SERV,WASHINGTON,MD. ARMED FORCES INST PATHOL,DEPT GENITOURINARY PATHOL,WASHINGTON,DC. NR 52 TC 18 Z9 18 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD OCT PY 1994 VL 152 IS 4 BP 1133 EP 1138 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA PF219 UT WOS:A1994PF21900022 PM 7915335 ER PT J AU THOMPSON, IM AF THOMPSON, IM TI PROSTATE-CANCER AND QUALITY-OF-LIFE SO JOURNAL OF UROLOGY LA English DT Editorial Material RP THOMPSON, IM (reprint author), BROOKE ARMY MED CTR,UROL SERV,SAN ANTONIO,TX, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD OCT PY 1994 VL 152 IS 4 BP 1180 EP 1180 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA PF219 UT WOS:A1994PF21900038 PM 8072089 ER PT J AU COCKMANTHOMAS, RA DUNN, DG INNSKEEP, W MONDY, WL SWEARENGEN, JR AF COCKMANTHOMAS, RA DUNN, DG INNSKEEP, W MONDY, WL SWEARENGEN, JR TI SPONTANEOUS OSTEOSARCOMA IN A C57BL/6J MOUSE SO LABORATORY ANIMAL SCIENCE LA English DT Article RP COCKMANTHOMAS, RA (reprint author), WALTER REED ARMY MED CTR,DIV VET MED,WASHINGTON,DC 20307, USA. NR 12 TC 6 Z9 6 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD OCT PY 1994 VL 44 IS 5 BP 531 EP 533 PG 3 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA PP079 UT WOS:A1994PP07900020 PM 7844967 ER PT J AU BARTH, J AF BARTH, J TI GRAHAM,BENJAMIN ON VALUE INVESTING - LESSONS FROM THE DEAN OF WALL-STREET - LOWE,J SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY, USA. NR 1 TC 0 Z9 0 U1 0 U2 2 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1994 VL 119 IS 16 BP 90 EP & PG 0 WC Information Science & Library Science SC Information Science & Library Science GA PK415 UT WOS:A1994PK41500150 ER PT J AU LACEY, PI AF LACEY, PI TI DEVELOPMENT OF A LUBRICITY TEST BASED ON THE TRANSITION FROM BOUNDARY LUBRICATION TO SEVERE ADHESIVE WEAR IN FUELS SO LUBRICATION ENGINEERING LA English DT Article DE BOUNDARY LUBRICATION; BENCH TEST; CORROSION INHIBITOR; DIESEL; ADHESIVE WEAR; VISCOSITY; HUMIDITY; POLISHING; SURFACE ROUGHNESS; CORROSION; SCUFFING; OXIDATIVE WEAR ID SURFACE AB Severe refinery practices to remove naturally occurring sulfur compounds affect fuel lubricity, and a laboratory wear test that accurately defines the lubricating qualities of diesel and kerosene fuels is urgently needed. This paper details the development of two closely related laboratory test procedures that predict fuel-related wear, cognizant of the contact conditions in full-scale equipment. Most preceding methodologies measure the wear scar produced under conditions of boundary lubrication in continuous sliding. In contrast, the tests described in the present study rely on the transition from mild boundary-lubricated wear to adhesive scuffing to define the lubricating qualities of the fuel. The resulting procedures allow the fuels to be either ranked using a continuous scale, or separated using a simple pass/fail criteria. Careful selection of the test parameters produced a sharp change in both friction and wear at the mechanism transition and wide separation between acceptable and unacceptable fluids. Both procedures were sensitive to the addition of trace quantities of lubricity additives and also showed directional correlation with refinery severity, as measured by sulfur and aromatic content. As a result, excellent correlation was achieved with full-scale equipment tests performed at a number of locations. However, the correlation achieved between laboratory wear tests and full-scale equipment fell below a critical viscosity. C1 NIST,WASHINGTON,DC. RP LACEY, PI (reprint author), USA,BELVOIR FUELS & LUBRICANTS RES FACIL,SW RES INST,SAN ANTONIO,TX, USA. NR 24 TC 5 Z9 5 U1 2 U2 7 PU SOC TRIBOLOGISTS & LUBRICATION ENGINEERS PI PARK RIDGE PA 838 BUSSE HIGHWAY, PARK RIDGE, IL 60068 SN 0024-7154 J9 LUBR ENG JI Lubric. Eng. PD OCT PY 1994 VL 50 IS 10 BP 749 EP 757 PG 9 WC Engineering, Mechanical SC Engineering GA PK426 UT WOS:A1994PK42600001 ER PT J AU COOPER, RD MEZA, RA SCHNEIDER, I AF COOPER, RD MEZA, RA SCHNEIDER, I TI ANOPHELES FARAUTI REFRACTORINESS TO MALARIA INFECTION WITH CULTURED GAMETOCYTES OF PLASMODIUM-FALCIPARUM SO MEDICAL AND VETERINARY ENTOMOLOGY LA English DT Note DE ANOPHELES FARAUTI; MALARIA VECTOR; PLASMODIUM FALCIPARUM; MALARIA; GAMETOCYTES; REFRACTORINESS ID MOSQUITOS; SELECTION; INVITRO C1 WALTER REED ARMY INST RES,WASHINGTON,DC. RP COOPER, RD (reprint author), ARMY MALARIA RES UNIT,LIVERPOOL MIL AREA,INGLEBURN,NSW 2174,AUSTRALIA. NR 10 TC 1 Z9 1 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0269-283X J9 MED VET ENTOMOL JI Med. Vet. Entomol. PD OCT PY 1994 VL 8 IS 4 BP 389 EP 390 DI 10.1111/j.1365-2915.1994.tb00105.x PG 2 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA PJ865 UT WOS:A1994PJ86500012 PM 7841495 ER PT J AU CARLIN, K CARLIN, S AF CARLIN, K CARLIN, S TI A POSSIBLE EXPLANATION FOR GROWTH-HORMONE RESISTANCE IN CHRONIC-RENAL-FAILURE SO MEDICAL HYPOTHESES LA English DT Note AB Perhaps the liver in renal failure significantly alters its pH in order to attempt to maintain homeostasis This alteration might explain the growth hormone resistance found in children with chronic renal failure. RP CARLIN, K (reprint author), USA,BROOKE ARMY MED CTR,DEPT ENDOCRINOL,SAN ANTONIO,TX 78234, USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH, MIDLOTHIAN, SCOTLAND EH1 3AF SN 0306-9877 J9 MED HYPOTHESES JI Med. Hypotheses PD OCT PY 1994 VL 43 IS 4 BP 193 EP 194 DI 10.1016/0306-9877(94)90064-7 PG 2 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA PN055 UT WOS:A1994PN05500002 PM 7837999 ER PT J AU LINDLER, LE HAYES, JM AF LINDLER, LE HAYES, JM TI NUCLEOTIDE-SEQUENCE OF THE SALMONELLA-TYPHI GROEL HEAT-SHOCK GENE SO MICROBIAL PATHOGENESIS LA English DT Note DE SALMONELLA TYPHI; HEAT SHOCK PROTEIN; GROEL; NUCLEOTIDE SEQUENCE ID STRESS PROTEINS AB Heat shock proteins (HSP) have been shown to elicit a strong immune response during infection by a variety of pathogens. The HSP60 gene of Salmonella typhi was amplified using oligonucleotide primers based on the Escherichia coli groEL sequence. The nucleotide sequence of the amplified fragment was determined and used to predict the amino acid sequence of S. typhi GroEL. The E. coli and S. typhi proteins were found to be highly similar; however, several non-conservative substitutions near the carboxy-termini of the two polypeptides were found. Knowing the amino acid sequence of the S. typhi HSP60 homologue will enhance our knowledge of host immune recognition of HSP produced by bacterial pathogens. RP LINDLER, LE (reprint author), WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, DEPT BACTERIAL DIS, WASHINGTON, DC 20307 USA. NR 10 TC 13 Z9 14 U1 0 U2 0 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0882-4010 J9 MICROB PATHOGENESIS JI Microb. Pathog. PD OCT PY 1994 VL 17 IS 4 BP 271 EP 275 DI 10.1006/mpat.1994.1072 PG 5 WC Immunology; Microbiology SC Immunology; Microbiology GA QC382 UT WOS:A1994QC38200007 PM 7715425 ER PT J AU STANLEY, OL AF STANLEY, OL TI LAO PEOPLES DEMOCRATIC-REPUBLIC VETERINARY PUBLIC-HEALTH PROJECT SO MILITARY MEDICINE LA English DT Article AB From May 21 to June 4, 1993, a collaborative training project involving U.S. Army veterinary personnel, the Lao-American Integrated Rural Development Project, and the Lao Department of Livestock and Veterinary Services occurred in the Houa Muang District of Houa Phan Province in northeastern Laos. The project focus was control of the major animal diseases of economic or public health importance in the area to include, but not limited to, hemorrhagic septicemia, anthrax, swine fever (hog cholera), and Newcastle disease. The project provided Lao veterinary personnel and villagers with didactic training and field demonstrations in disease control practices. Supplies and equipment necessary to continue disease control activities were provided to the district at the conclusion of the training and field demonstrations. The project was designed to be compatible with disease reporting and surveillance systems at district, province, and national levels and be exportable to other districts and provinces. In addition to disease-control efforts, blood and fecal parasite surveys were conducted. RP STANLEY, OL (reprint author), USAMEDDAC,VET SERV,FT SILL,OK 73503, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1994 VL 159 IS 10 BP 639 EP 643 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA QB527 UT WOS:A1994QB52700004 PM 7870320 ER PT J AU RITCHIE, EC AF RITCHIE, EC TI PSYCHIATRIC MEDICATIONS FOR DEPLOYMENT SO MILITARY MEDICINE LA English DT Article AB Standard medical sick-call chests used in the military contain either outdated or no psychiatric medications. Yet certain psychiatric medications are either useful or essential for the field and deployment. This article discusses suitable medications for both psychiatric emergencies and for chronic treatment of depression or anxiety. Psychiatric medications to avoid in deployment are also listed. Some dosing guidelines are provided. The article ends with a proposed ''psychiatric sick-call chest'' to be prepared in advance of deployment. RP RITCHIE, EC (reprint author), WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20307, USA. NR 0 TC 7 Z9 7 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1994 VL 159 IS 10 BP 647 EP 649 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA QB527 UT WOS:A1994QB52700006 PM 7870322 ER PT J AU COY, J AF COY, J TI COMBAT INJURY WITH CHRONIC OSTEOMYELITIS COMPLICATED BY SQUAMOUS-CELL CARCINOMA SO MILITARY MEDICINE LA English DT Article AB Penetrating injuries of the extremity are common in combat. The patient described in this paper sustained such an injury in Vietnam. He exhibited the frequent complication of chronic osteomyelitis and eventually the rare complication of squamous cell carcinoma. RP COY, J (reprint author), UNIFORMED SERV UNIV HLTH SCI,HARRY S TRUMAN MEM VET HOSP,USASOC,800 HOSP DR,COLUMBIA,MO 65201, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1994 VL 159 IS 10 BP 665 EP 667 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA QB527 UT WOS:A1994QB52700012 PM 7870328 ER PT J AU ZUBER, M HOOVER, TA POWELL, BS COURT, DL AF ZUBER, M HOOVER, TA POWELL, BS COURT, DL TI ANALYSIS OF THE RNC LOCUS OF COXIELLA-BURNETII SO MOLECULAR MICROBIOLOGY LA English DT Article ID GTP-BINDING PROTEIN; ESCHERICHIA-COLI; RNASE-III; PSEUDOMONAS-AERUGINOSA; BACTERIOPHAGE-LAMBDA; RIBONUCLEASE-III; S-POMBE; GENE; OPERON; ERA AB A 3.2 kb EcoRI genomic DNA fragment of Coxiella burnetii was isolated by virtue of its ability to suppress mucoidy in Escherichia coli. Nucleotide sequence analysis revealed the presence of the genes homologous to me, era and recO of E. coli. Suppression of capsule synthesis, measured by beta-galactosidase expression in lon(-) cps-lac fusion strains of E. coli, is caused by gene-dosage effects of the plasmid-borne me genes of either C. burnetii or E. coli. The rnc gene of C. burnetii complemented rnc(-) E. coli hosts for lambda plaque morphology and stimulation of lambda N gene expression. We also demonstrated heterologous complementation of an E. coli strain defective for the expression of Era, an essential protein in E. coli, using the plasmid-borne C. burnetii era. Under the control of the bacteriophage lambda P-L promoter, this 3.2 kb EcoRI DNA fragment directed the synthesis in E. coli of three proteins with approximate molecular masses of 35, 27 and 25 kDa. Antibodies against purified E. coli Era protein cross-reacted with the 35 kDa protein of C. burnetii on Western blots. C1 USA,MED RES INST INFECT DIS,DIV TOXICOL,FREDERICK,MD 21702. USA,MED RES INST INFECT DIS,DIV BACTERIOL,FREDERICK,MD 21702. RP ZUBER, M (reprint author), NCI,FREDERICK CANC RES & DEV CTR,MOLEC CONTROL & GENET SECT,CHROMOSOME BIOL LAB,FREDERICK,MD 21702, USA. FU NCI NIH HHS [N01-CO-74101] NR 43 TC 25 Z9 28 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0950-382X J9 MOL MICROBIOL JI Mol. Microbiol. PD OCT PY 1994 VL 14 IS 2 BP 291 EP 300 DI 10.1111/j.1365-2958.1994.tb01290.x PG 10 WC Biochemistry & Molecular Biology; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA PM675 UT WOS:A1994PM67500011 PM 7830573 ER PT J AU PERLSTEIN, RS MEHTA, NR MOUGEY, EH NETA, R WHITNALL, MH AF PERLSTEIN, RS MEHTA, NR MOUGEY, EH NETA, R WHITNALL, MH TI SYSTEMICALLY ADMINISTERED HISTAMINE H-1 AND H-2-RECEPTOR ANTAGONISTS DO NOT BLOCK THE ACTH RESPONSE TO BACTERIAL LIPOPOLYSACCHARIDE AND INTERLEUKIN-1 SO NEUROENDOCRINOLOGY LA English DT Article DE HISTAMINE; HISTAMINE RECEPTORS; HISTAMINE ANTAGONISTS; LIPOPOLYSACCHARIDE; INTERLEUKIN-1; ADRENOCORTICOTROPIC HORMONE; CORTICOTROPIN ID TUMOR-NECROSIS-FACTOR; CORTICOTROPIN-RELEASING HORMONE; OPIOMELANOCORTIN-DERIVED PEPTIDES; ADRENOCORTICOTROPIC HORMONE; INTRACEREBROVENTRICULAR INJECTION; THERAPEUTIC EFFICACY; RAT HEPATOCYTES; BETA-ENDORPHIN; CELLS INVITRO; SECRETION AB The administration of lipopolysaccharide (LPS) results in the activation of the hypothalamic-pituitary-adrenal axis (HPAA). We recently reported that the participation and interaction of LPS-induced proinflammatory cytokines were obligatory for the stimulation of adrenocorticotropic hormone (ACTH) release by LPS. LPS and LPS-derived cytokines also stimulate the release of histamine (HA). HA is a known hypothalamic neurotransmitter and activates the HPAA. Therefore, to elucidate the role of HA in LPS- and cytokine-induced ACTH release, we evaluated the effects of several HA H-1 and H-2 receptor antagonists on the ACTH response to LPS, recombinant human interleukin-1 alpha (rhIL-1 alpha) and HA in mice. Although all 3 of the H-1 receptor antagonists administered (mepyramine (MEP), diphenhydramine (DPH) or promethazine (PMZ)) were able to block the 10-min ACTH response to HA, only PMZ (a less selective H-1 receptor antagonist than MEP) was able to reduce the LPS- or rhIL-1 alpha-induced ACTH responses. Ranitidine, a powerful and selective H-2 receptor antagonist, had little effect on the LPS- and rhIL-1 alpha-induced ACTH responses, while metiamide (MET), a much less potent first-generation H-2 receptor antagonist, substantially diminished ACTH release. The greater effectiveness of PMZ, in contrast to MEP or DPH, probably relates to the ability of phenothiazine derivatives to inhibit non-HA-dependent pathways involved in the stimulation of the HPAA by cytokines; the same may be true of MET. Our results suggest that, in contrast to the essential role of HA in the activation of the HPAA by noninflammatory stressors, the stimulation of ACTH release by LPS and rhIL-1 alpha is not as dependent on the participation of either the H-1 or the H-2 receptor. C1 ARMED FORCES RADIOBIOL RES INST,DEPT PHYSIOL,BETHESDA,MD. WALTER REED ARMY INST RES,DEPT MED NEUROSCI,NEUROENDOCRINOL & NEUROCHEM BRANCH,WASHINGTON,DC. RP PERLSTEIN, RS (reprint author), ARMED FORCES RADIOBIOL RES INST,DEPT EXPTL HEMATOL,BETHESDA,MD 20889, USA. NR 65 TC 7 Z9 8 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0028-3835 J9 NEUROENDOCRINOLOGY JI Neuroendocrinology PD OCT PY 1994 VL 60 IS 4 BP 418 EP 425 DI 10.1159/000126776 PG 8 WC Endocrinology & Metabolism; Neurosciences SC Endocrinology & Metabolism; Neurosciences & Neurology GA PH755 UT WOS:A1994PH75500009 PM 7824083 ER PT J AU SARDAR, DK VIZCARRA, S ISLAM, MA ALLIK, TH SHARP, EJ PINTO, AA AF SARDAR, DK VIZCARRA, S ISLAM, MA ALLIK, TH SHARP, EJ PINTO, AA TI SPECTROSCOPIC ANALYSIS AND THE EFFECTS OF COLOR-CENTERS ON THE LASER PERFORMANCE OF ND3+CAZN2Y2GE3O(12) SO OPTICAL MATERIALS LA English DT Article ID NEODYMIUM AB Spectroscopic and EPR investigations of Nd3+-doped CaZn2Y2Ge3O12 (CAZGAR) have been performed. The absorption, fluorescence, excitation spectra and fluorescence lifetime have been measured at room temperature. The Judd-Ofelt theory has been applied to the measured optical absorption intensities to predict the radiative decay rates, branching ratios, and peak stimulated emission cross section from the metastable F-4(3/2) state to the I-4(9/2) manifold. The fluorescence lifetime of the F-4(3/2) level of Nd3+ at low concentration in this host was measured to be 285 +/- 10 mu s, which is longer than that for Nd3+:YAG. Color centers located at zinc octahedral sites have been produced in these crystals by ultraviolet irradiation and have been detected by EPR techniques. The effects of the color centers on the potential laser characteristics of this material are discussed. C1 SCI APPLICAT INT CORP, MCLEAN, VA 22102 USA. USA, RES LAB, FT BELVOIR, VA 22060 USA. RP UNIV TEXAS, DIV EARTH & PHYS SCI, SAN ANTONIO, TX 78249 USA. NR 29 TC 13 Z9 13 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0925-3467 EI 1873-1252 J9 OPT MATER JI Opt. Mater. PD OCT PY 1994 VL 3 IS 4 BP 257 EP 263 DI 10.1016/0925-3467(94)90038-8 PG 7 WC Materials Science, Multidisciplinary; Optics SC Materials Science; Optics GA QQ358 UT WOS:A1994QQ35800005 ER PT J AU HUTCHINSON, JA VERDUN, HR CHAI, BHT ZANDI, B MERKLE, LD AF HUTCHINSON, JA VERDUN, HR CHAI, BHT ZANDI, B MERKLE, LD TI SPECTROSCOPIC EVALUATION OF CAYALO4 DOPED WITH TRIVALENT ER, TM, YB AND HO FOR EYESAFE LASER APPLICATIONS SO OPTICAL MATERIALS LA English DT Article ID RARE-EARTH IONS; CRYSTAL-FIELD ANALYSIS; ENERGY-LEVELS; CANDALO4; SPECTRA; YAG; ND AB Spectroscopic properties of relevance for laser applications have been studied for rare earths in CaYAlO4. Fitting of a theoretical model to observed energy levels yields crystal field parameters and unobserved levels. Structural disorder leads to broad linewidths, but cross sections are larger than in many common hosts. Tm-Tm cross relaxation rates are comparable to those in Tm:YAG, and Yb-Er transfer rates are comparable to those in Yb, Er:phosphate glass. Room temperature Yb-Er upconversion is stronger than in YAG, but modeling shows that neither unconversion nor population of Er I-4(13/2) is very efficient upon pumping Yb. The host's yellow color intensifies upon annealing in air, a potential problem for visible laser operation. Tm or Ho 2 mu m laser operation, or Er 1.5 mu m operation upon direct excitation of Er I-4(13/2), are more promising. C1 FIBERTEK INC,HERNDON,VA 22070. UNIV CENT FLORIDA,CTR RES ELECTROOPT & LASERS,DEPT PHYS,ORLANDO,FL 32826. UNIV CENT FLORIDA,CTR RES ELECTROOPT & LASERS,DEPT MECH ENGN,ORLANDO,FL 32826. USA,RES LAB,NONLINEAR OPT DEVICES BRANCH,FT BELVOIR,VA 22060. RP HUTCHINSON, JA (reprint author), NIGHT VIS & ELECTR SENSORS DIRECTORATE,DIV LASERS & PHOTON,FT BELVOIR,VA 22060, USA. NR 23 TC 34 Z9 34 U1 4 U2 21 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0925-3467 J9 OPT MATER JI Opt. Mater. PD OCT PY 1994 VL 3 IS 4 BP 287 EP 306 DI 10.1016/0925-3467(94)90042-6 PG 20 WC Materials Science, Multidisciplinary; Optics SC Materials Science; Optics GA QQ358 UT WOS:A1994QQ35800009 ER PT J AU SAYSON, SC DUCEY, JP MAYBREY, JB WESLEY, RL VERMILION, D AF SAYSON, SC DUCEY, JP MAYBREY, JB WESLEY, RL VERMILION, D TI SCIATIC ENTRAPMENT NEUROPATHY ASSOCIATED WITH AN ANOMALOUS PIRIFORMIS MUSCLE SO PAIN LA English DT Note DE SCIATICA; SCIATIC NERVE; PIRIFORMIS MUSCLE; NERVE ENTRAPMENT; NEUROPATHY ENTRAPMENT; MYOFASCIAL BAND AB Piriformis syndrome is an often overlooked cause of sciatica that typically responds to intramuscular local anesthetic and steroid injection. In this report, our patient presented with sciatica that responded poorly to epidural steroid injection and only transiently to piriformis injection. Surgical exploration of the sciatic nerve revealed a fascial constricting band around the nerve as well as a piriformis muscle lying anterior to the nerve. This unusual anatomical relationship between the pirifornis and the sciatic nerve has not been previously described in the literature. Subsequent sectioning of the anomalous muscle and the constricting band yielded complete resolution of our patient's symptoms. C1 PRESBYTERIAN HOSP,DEPT ANESTHESIOL,CHARLOTTE,NC 28277. UNIV TEXAS,DEPT ORTHOPED SURG,SAN ANTONIO,TX 78284. LEWIS GALE CLIN,DEPT ANESTHESIOL,SALEM,VA 24018. WEED ARMY HOSP,DEPT ORTHOPED SURG,FT IRWIN,CA 92310. RP SAYSON, SC (reprint author), BROOKE ARMY MED CTR,DEPT SURG,ANESTHESIOL SERV,PAIN CLIN,FT SAM HOUSTON,TX 78234, USA. NR 7 TC 61 Z9 63 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3959 J9 PAIN JI Pain PD OCT PY 1994 VL 59 IS 1 BP 149 EP 152 DI 10.1016/0304-3959(94)90060-4 PG 4 WC Anesthesiology; Clinical Neurology; Neurosciences SC Anesthesiology; Neurosciences & Neurology GA PL956 UT WOS:A1994PL95600018 PM 7854796 ER PT J AU WISWELL, TE PEABODY, SS DAVIS, JM SLAYTER, MV BENT, RC MERRITT, TA AF WISWELL, TE PEABODY, SS DAVIS, JM SLAYTER, MV BENT, RC MERRITT, TA TI SURFACTANT THERAPY AND HIGH-FREQUENCY JET VENTILATION IN THE MANAGEMENT OF A PIGLET MODEL OF THE MECONIUM ASPIRATION SYNDROME SO PEDIATRIC RESEARCH LA English DT Article ID RESPIRATORY-DISTRESS SYNDROME; PULMONARY SURFACTANT; PROTEIN-A; FAILURE; NEWBORNS; INFANTS; FLUID AB In vitro data have shown a concentration-dependent inhibition of surfactant by meconium, while anecdotal reports demonstrate improved oxygenation after surfactant replacement in babies with meconium aspiration syndrome, particularly in conjunction with high-frequency jet ventilation. We randomized 70 newborn piglets to either conventional or high-frequency jet ventilation, followed by insufflation of 3 mL/kg of a 33% meconium solution. Each group was further randomized to one of five surfactant therapies: 1) control, 2) 4 mL/kg Survanta, 3) 8 mL/kg Survanta, 4) 5 mL/kg Exosurf, or 5) 10 mL/kg Exosurf. We followed arterial blood gases and ventilator requirements over 6 h of ventilation. Aspirates of airway fluids were obtained for surface tension measurements, as well as total protein and phospholipid concentrations. Using a previously established scoring system, a pathologist blinded to treatment evaluated four sections of lung per animal for histologic changes of meconium aspiration syndrome. There were no differences noted between groups in any physiologic parameter measured (mean airway pressure, arterial partial pressure of oxygen/alveolar partial pressure of oxygen ratio, etc.) during the 6 h of ventilation. Airway fluid aspirate total protein concentrations increased significantly after meconium instillation (4- to 5-fold, p < 0.007) and remained elevated in spite of surfactant therapy. There was an initial decline in airway phospholipid concentrations after meconium instillation followed by a rise to levels equal to or greater than premeconium levels. Surface tension measurements increased in all groups after meconium insufflation (p < 0.012) and did not decline thereafter, despite standard and twice-standard surfactant doses of both types. Histology of surfactant-treated animals was similar to that of control piglets regardless of ventilator management. Five of 56 animals receiving surfactant had overt pulmonary hemorrhage. These data suggest that surfactant therapy with or without high-frequency jet ventilation in this animal model of meconium aspiration syndrome does not improve oxygenation, surface tension, or lung histology. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,WASHINGTON,DC 20307. SUNY STONY BROOK,WINTHROP UNIV HOSP,MINEOLA,NY 11501. UNIV CALIF DAVIS,SACRAMENTO,CA 95817. RP WISWELL, TE (reprint author), THOMAS JEFFERSON UNIV,DEPT PEDIAT,DIV NEONATOL,1025 WALNUT ST,SUITE 700,PHILADELPHIA,PA 19107, USA. NR 19 TC 49 Z9 51 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD OCT PY 1994 VL 36 IS 4 BP 494 EP 500 DI 10.1203/00006450-199410000-00015 PG 7 WC Pediatrics SC Pediatrics GA PH403 UT WOS:A1994PH40300013 PM 7816525 ER PT J AU YUEN, DA REUTELER, DM BALACHANDAR, S STEINBACH, V MALEVSKY, AV SMEDSMO, JJ AF YUEN, DA REUTELER, DM BALACHANDAR, S STEINBACH, V MALEVSKY, AV SMEDSMO, JJ TI VARIOUS INFLUENCES ON 3-DIMENSIONAL MANTLE CONVECTION WITH PHASE-TRANSITIONS SO PHYSICS OF THE EARTH AND PLANETARY INTERIORS LA English DT Article ID INFINITE PRANDTL NUMBER; 3-DIMENSIONAL COMPRESSIBLE CONVECTION; HARD-TURBULENT REGIME; THERMAL-CONVECTION; EARTHS MANTLE; LAYERED CONVECTION; INSTABILITIES; EVOLUTION; DEPTH; MODEL AB Three-dimensional numerical calculations of mantle convection with the two major phase transitions have been carried out in a 5 x 5 x 1 configuration to study the effects of increasing vigor of convection, internal heating and extremely negative Clapeyron slope of the spinel-perovskite phase transition. Depth-dependent properties of thermal expansivity, viscosity and thermal conductivity have been incorporated. Three-dimensional solutions for surface Rayleigh number (Ra-s) between 2 x 10(6) and 4 x 10(8) show that there is a distinct transition between Ra-s = 4 x 10(7) and 10(8) in which the system changes from single-layered to layered convection with the mass flux decreasing to below 10% at Ra-s = 10(8). Surface heat flux does not decrease with increasing Ra-s and with the accompanying decrease in the mass flux at the transition zone. The effects of internal heating are to reduce the wavelengths of the planforms which cause greater degree of layering in the system. Comparison between 2D and 3D results shows that there is a greater mass flu passing through the transition zone in the 2D models for the 5 x 5 x 1 box, but for larger aspect ratio (8 X 8 X 1) the 3D flows become more layered than the corresponding 2D solution. Increasing the magnitude of the negative Clapeyron slope by three times the experimental value can bring about a dramatic reduction in the amount of mass flux across the 670 km discontinuity. Results from a 8 x 8 x 1 box show that a greater amount of layering is produced in the larger aspect-ratio configuration because of the shorter wavelengths of the developed planforms. Increasing the degrees of freedom in a 3D system by either greater amounts of convective vigor or larger domains may give rise to a greater tendency for layered convection. Three-dimensional spherical shell models may produce a greater degree of layering than the corresponding axisymmetric models. C1 UNIV MINNESOTA,MINNESOTA SUPERCOMP INST,MINNEAPOLIS,MN 55415. UNIV ILLINOIS,DEPT THEORET & APPL MECH,URBANA,IL 61801. UNIV COLOGNE,INST GEOPHYS & METEOROL,D-50923 COLOGNE,GERMANY. UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55415. RP YUEN, DA (reprint author), UNIV MINNESOTA,DEPT GEOL & GEOPHYS,MINNEAPOLIS,MN 55415, USA. RI Balachandar, Sivaramakrishnan/E-7358-2011 NR 40 TC 52 Z9 52 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0031-9201 J9 PHYS EARTH PLANET IN JI Phys. Earth Planet. Inter. PD OCT PY 1994 VL 86 IS 1-3 BP 185 EP 203 DI 10.1016/0031-9201(94)05068-6 PG 19 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA PQ827 UT WOS:A1994PQ82700012 ER PT J AU HEBERT, MA POTEGAL, M MEYERHOFF, JL AF HEBERT, MA POTEGAL, M MEYERHOFF, JL TI FLIGHT-ELICITED ATTACK AND PRIMING OF AGGRESSION IN NONAGGRESSIVE HAMSTERS SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE HAMSTERS; AGGRESSION; ATTACK PRIMING; FLIGHT-ELICITED ATTACK ID MESOCRICETUS-AURATUS; GOLDEN-HAMSTER; INTRASPECIFIC AGGRESSION; BEHAVIOR; RAT AB We report a technique for inducing attack in apparently nonaggressive hamsters that rakes advantage of several behavioral effects: (a) the vigorous flight mat repeatedly defeated hamsters display in the presence of conspecifics, (b) the potent, attack-eliciting properties of such Right, and (c) attack priming (i.e., aggressive arousal from exposure to an initial stimulus animal carries over to exposure to a second one). Resident hamsters that had consistently failed to attack nonfleeing intruders were found to readily attack intruders that did Ree. But repeated exposure to the fleeing intruders alone did not induce long-term changes in aggressiveness. However, flight-elicited attack did successfully prime attack onto nonfleeing intruders presented immediately after the fleeing intruder was removed. Repealing such priming transfer trials induced long-term changes in the formerly nonaggressive subjects. We conclude that this is an effective procedure for inducing aggression that would be preferred when it is important to avoid exposing subjects to aversive stimuli. The changes in behavior that we observed seem to reflect heightened motivational levels. RP HEBERT, MA (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307, USA. NR 24 TC 9 Z9 10 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD OCT PY 1994 VL 56 IS 4 BP 671 EP 675 DI 10.1016/0031-9384(94)90225-9 PG 5 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA PE508 UT WOS:A1994PE50800009 PM 7800731 ER PT J AU VOGELGESANG, SA KLIPPLE, GL AF VOGELGESANG, SA KLIPPLE, GL TI THE MANY GUISES OF AMYLOIDOSIS - CLINICAL PRESENTATIONS AND DISEASE ASSOCIATIONS SO POSTGRADUATE MEDICINE LA English DT Article ID SYSTEMIC AMYLOIDOSIS AB Amyloidosis occurs in association with many diseases and can also be idiopathic. It is usually a systemic disease with variable presentations. The diagnosis should be suspected in patients with unexplained proteinuria, cardiomyopathy, congestive heart failure, peripheral neuropathy, carpal tunnel syndrome, macroglossia, or hepatosplenomegaly. Amyloidosis generally has a poor prognosis and responds poorly to therapy. Much needs to be learned about its pathogenesis and treatment possibilities. RP VOGELGESANG, SA (reprint author), WALTER REED ARMY MED CTR,RHEUMATOL SERV,WASHINGTON,DC 20307, USA. NR 13 TC 5 Z9 5 U1 0 U2 0 PU MCGRAW HILL HEALTHCARE PUBLICATIONS PI MINNEAPOLIS PA 4530 WEST 77TH ST, MINNEAPOLIS, MN 55435-5000 SN 0032-5481 J9 POSTGRAD MED JI Postgrad. Med. PD OCT PY 1994 VL 96 IS 5 BP 119 EP & PG 0 WC Medicine, General & Internal SC General & Internal Medicine GA PM182 UT WOS:A1994PM18200012 PM 7937410 ER PT J AU SAXENA, A QIAN, NF KOVACH, IM KOZIKOWSKI, AP PANG, YP VELLOM, DC RADIC, Z QUINN, D TAYLOR, P DOCTOR, BP AF SAXENA, A QIAN, NF KOVACH, IM KOZIKOWSKI, AP PANG, YP VELLOM, DC RADIC, Z QUINN, D TAYLOR, P DOCTOR, BP TI IDENTIFICATION OF AMINO-ACID-RESIDUES INVOLVED IN THE BINDING OF HUPERZINE-A TO CHOLINESTERASES SO PROTEIN SCIENCE LA English DT Article DE CHOLINESTERASES; HUPERZINE A; INHIBITOR; MOLECULAR MODELING; SITE-DIRECTED MUTAGENESIS ID CATALYTIC CENTER; ACETYLCHOLINESTERASE; INHIBITION; BUTYRYLCHOLINESTERASE; SPECIFICITY; EXPRESSION; TORPEDO AB Huperzine A, a potential agent for therapy in Alzheimer's disease and for prophylaxis of organophosphate toxicity, has recently been characterized as a reversible inhibitor of cholinesterases. To examine the specificity of this novel compound in more detail, we have examined the interaction of the 2 stereoisomers of Huperzine A with cholinesterases and site-specific mutants that detail the involvement of specific amino acid residues. Inhibition of fetal bovine serum acetylcholinesterase by (-)-Huperzine A was 35-fold more potent than (+)-Huperzine A, with K-I values of 6.2 nM and 210 nM, respectively. In addition, (-)-Huperzine A was 88-fold more potent in inhibiting Torpedo acetylcholinesterase than (+)-Huperzine A, with K-I values of 0.25 mu M and 22 mu M, respectively. Far larger K-I values that did not differ between the 2 stereoisomers were observed with horse and human serum butyrylcholinesterases. Mammalian acetylcholinesterase, Torpedo acetylcholinesterase, and mammalian butyrylcholinesterase can be distinguished by the amino acid Tyr, Phe, or Ala in the 330 position, respectively. Studies with mouse acetylcholinesterase mutants, Tyr 337(330) Phe and Tyr 337(330) Ala yielded a difference in reactivity that closely mimicked the native enzymes. In contrast, mutation of the conserved Glu 199 residue to Gin in Torpedo acetylcholinesterase produced only a 3-fold increase in K-I value for the binding of Huperzine A. Molecular mechanics energy minimization of the complexes formed between each of the 2 stereoisomers of Huperzine A and fetal bovine serum acetylcholinesterase, Torpedo acetylcholinesterase, or human butyrylcholinesterase also revealed that (-)-Huperzine A gave a better fit than (+)-Huperzine A and implicated Tyr 337(330) in the stereoselectivity of Huperzine A. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC 20307. CATHOLIC UNIV AMER,DEPT CHEM,WASHINGTON,DC 20064. MAYO CLIN,JACKSONVILLE,FL 32224. UNIV CALIF SAN DIEGO,LA JOLLA,CA 92093. UNIV ZAGREB,INST MED RES,ZAGREB 41000,CROATIA. UNIV IOWA,DEPT CHEM,IOWA CITY,IA. NR 25 TC 48 Z9 51 U1 0 U2 5 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 40 WEST 20TH STREET, NEW YORK, NY 10011-4211 SN 0961-8368 J9 PROTEIN SCI JI Protein Sci. PD OCT PY 1994 VL 3 IS 10 BP 1770 EP 1778 PG 9 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA PR260 UT WOS:A1994PR26000017 PM 7849595 ER PT J AU PRIDHAM, KF CHANG, AS CHIU, YM AF PRIDHAM, KF CHANG, AS CHIU, YM TI MOTHERS PARENTING SELF-APPRAISALS - THE CONTRIBUTION OF PERCEIVED INFANT TEMPERAMENT SO RESEARCH IN NURSING & HEALTH LA English DT Article ID SOCIAL SUPPORT; REVISION; MODEL AB To learn how a mother's perception of her infant's temperament contributes to her appraisal of her parenting and of her problem-solving competence during the first 3 months postpartum, we explored a conceptual model, including infant gender and maternal attributes (education and parity) and the personal and social context of the parenting experience (infant centrality and life change), in a sample of 117 mothers. The set of temperament variables contributed to the variance in both parenting evaluation and problem-solving competence at 1 and 3 months. The pattern of infant temperament variables contributing to maternal self-appraisal variables at 1 and at 3 months suggests change in the temperament variables that are salient to mothers as the infants row older. (C) 1994 John Wiley & Sons, Inc. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIV WISCONSIN,DEPT FAMILY MED & PRACTICE,MADISON,WI 53792. SPSS INC,CHICAGO,IL. RP PRIDHAM, KF (reprint author), UNIV WISCONSIN,SCH NURSING,600 HIGHLAND AVE,MADISON,WI 53792, USA. NR 31 TC 30 Z9 30 U1 2 U2 2 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0160-6891 J9 RES NURS HEALTH JI Res. Nurs. Health PD OCT PY 1994 VL 17 IS 5 BP 381 EP 392 DI 10.1002/nur.4770170509 PG 12 WC Nursing SC Nursing GA PH620 UT WOS:A1994PH62000008 PM 8090949 ER PT J AU MAHADIK, SP MUKHERJEE, S CORRENTI, EE KELKAR, HS WAKADE, CG COSTA, RM SCHEFFER, R AF MAHADIK, SP MUKHERJEE, S CORRENTI, EE KELKAR, HS WAKADE, CG COSTA, RM SCHEFFER, R TI PLASMA-MEMBRANE PHOSPHOLIPID AND CHOLESTEROL DISTRIBUTION OF SKIN FIBROBLASTS FROM DRUG-NAIVE PATIENTS AT THE ONSET OF PSYCHOSIS SO SCHIZOPHRENIA RESEARCH LA English DT Article DE PSYCHOSIS; PLASMA MEMBRANE PHOSPHOLIPID; CHOLESTEROL; FIBROBLAST ID MAGNETIC-RESONANCE SPECTROSCOPY; POLYUNSATURATED FATTY-ACIDS; CULTURED HUMAN-FIBROBLASTS; SCHIZOPHRENIC-PATIENTS; ABNORMAL GROWTH; BRAIN; METABOLISM; REPLICATION; PLATELETS; ISCHEMIA AB Contents of plasma membrane major phospholipids, cholesterol, and cholesteryl esters of fibroblasts from drug-naive psychotic patients were compared with those from normal controls. Total membrane lipids were extracted and individual lipids were separated on high-performance thin-layer chromatography. The contents of lipid bands were quantitated by densitometric scanning and comparing with standards. Contents of total phospholipids as well as phosphatidylserine, phosphatidylinositol and phosphatidylethanolamine were significantly lower in fibroblasts from patients than in those from normal controls (P < 0.001, < 0.005, < 0.05, < 0.05 respectively). Total cholesterol fraction and cholesteryl esters were also significantly lower in fibroblasts from patient (P < 0.005, < 0.001 respectively). These changes were not related to differences in age or sex. These data support the hypothesis that schizophrenia is associated with disordered membrane lipid metabolism, and that this predates the onset of psychosis. C1 DWIGHT D EISENHOWER ARMY MED CTR, FT GORDON, GA USA. DEPT VET AFFAIRS MED CTR, AUGUSTA, GA 30904 USA. RP MED COLL GEORGIA, DEPT PSYCHIAT & HLTH BEHAV, AUGUSTA, GA 30912 USA. FU NIMH NIH HHS [MH 46546, MH 41961, MH 47002] NR 54 TC 60 Z9 61 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-9964 EI 1573-2509 J9 SCHIZOPHR RES JI Schizophr. Res. PD OCT PY 1994 VL 13 IS 3 BP 239 EP 247 DI 10.1016/0920-9964(94)90048-5 PG 9 WC Psychiatry SC Psychiatry GA PM206 UT WOS:A1994PM20600007 PM 7841137 ER PT J AU BURRIS, HA FIELDS, S GRALLA, R LIVINGSTON, RB SHULMAN WOZNIAC CRAWFORD, J AF BURRIS, HA FIELDS, S GRALLA, R LIVINGSTON, RB SHULMAN WOZNIAC CRAWFORD, J TI SUMMARY OF DATA FROM IN-VITRO AND PHASE-I VINORELBINE (NAVELBINE) STUDIES SO SEMINARS IN ONCOLOGY LA English DT Article; Proceedings Paper CT Symposium on the Current Status of Navelbine in Non-Small Cell Lung Cancer CY NOV 11-14, 1993 CL DALLAS, TX ID VINBLASTINE C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. RP BURRIS, HA (reprint author), CANC THERAPY & RES CTR S TEXAS,INST DRUG DEV,DEPT CLIN RES,8122 DATAPOINT DR,SUITE 1000,SAN ANTONIO,TX 78229, USA. NR 18 TC 33 Z9 33 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0093-7754 J9 SEMIN ONCOL JI Semin. Oncol. PD OCT PY 1994 VL 21 IS 5 SU 10 BP 14 EP 20 PG 7 WC Oncology SC Oncology GA PQ274 UT WOS:A1994PQ27400003 PM 7973764 ER PT J AU EISENBERGER, MA CRAWFORD, ED WOLF, M BLUMENSTEIN, B MCLEOD, DG BENSON, R DORR, FA BENSON, M SPAULDING, JT AF EISENBERGER, MA CRAWFORD, ED WOLF, M BLUMENSTEIN, B MCLEOD, DG BENSON, R DORR, FA BENSON, M SPAULDING, JT TI PROGNOSTIC FACTORS IN STAGE D-2 PROSTATE-CANCER - IMPORTANT IMPLICATIONS FOR FUTURE TRIALS - RESULTS OF A COOPERATIVE INTERGROUP STUDY (INT.0036) SO SEMINARS IN ONCOLOGY LA English DT Article ID CARCINOMA C1 JOHNS HOPKINS UNIV,CTR ONCOL,DIV MED ONCOL,SW ONCOL GRP,BALTIMORE,MD 21287. UNIV COLORADO,DEPT SURG,DIV UROL,SW ONCOL GRP,DENVER,CO. FRED HUTCHINSON CANC RES CTR,SEATTLE,WA 98104. SW ONCOL GRP,CTR STAT,SEATTLE,WA. WALTER REED ARMY MED CTR,DEPT SURG,UROL SERV,WASHINGTON,DC 20307. UNIFORMED UNIV HLTH SCI,UROL SERV,NATL PROSTATE CANC PROJECT,WASHINGTON,DC. MAYO CLIN & MAYO GRAD SCH MED,DEPT UROL,N CENT CANC TREATMENT GRP,ROCHESTER,MN 55901. NCI,DIV CANC TREATMENT,CANC THERAPY EVALUAT PROGRAM,CLIN INVEST BRANCH,BETHESDA,MD 20892. COLUMBIA UNIV,DEPT UROL,NATL PROSTAT CANC PROJECT,NEW YORK,NY. UNIV CALIF SAN FRANCISCO,DEPT UROL,NO CALIF ONCOL GRP,SAN FRANCISCO,CA 94143. RP EISENBERGER, MA (reprint author), JOHNS HOPKINS UNIV,CTR ONCOL,DIV MED ONCOL,MID ATLANTIC ONCOL PROGRAM,600 N WOLFE ST,BALTIMORE,MD 21287, USA. NR 23 TC 79 Z9 80 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0093-7754 J9 SEMIN ONCOL JI Semin. Oncol. PD OCT PY 1994 VL 21 IS 5 BP 613 EP 619 PG 7 WC Oncology SC Oncology GA PM940 UT WOS:A1994PM94000012 PM 7939752 ER PT J AU STALLWORTH, PE LI, J GREENBAUM, SG CROCE, F SLANE, S SALOMON, M AF STALLWORTH, PE LI, J GREENBAUM, SG CROCE, F SLANE, S SALOMON, M TI NA-23 NMR AND COMPLEX IMPEDANCE STUDIES OF GEL ELECTROLYTES BASED ON POLY (ACRYLONITRILE) SO SOLID STATE IONICS LA English DT Article DE GEL ELECTROLYTES; NMR STUDY OF NA+ MOTION; POLY(ACRYLONITRILE) GELS ID IONIC-CONDUCTIVITY; POLYACRYLONITRILE AB Highly conducting gel electrolytes prepared from mixtures of poly(acrylonitrile) (PAN), ethylene carbonate (EC), propylene carbonate (PC) and NaClO4 have been studied by complex impedance, differential scanning calorimetry (DSC) and Na-23 nuclear magnetic resonance (NMR) spectroscopy. Ionic motional correlation times spanning nearly five orders of magnitude, probed by temperature-dependent dynamical features of the Na-23 quadrupole-broadened NMR lineshape, are strongly influenced by the single glass transition temperature observed in the gel electrolyte. Dielectric measurements of mixtures of PAN, EC and PC suggest that the polar nitrile group in PAN may interact with Na+ ions in the gel. All results are consistent with the conclusion that PAN provides stability to the gel network down to the immediate vicinity of the Na+ ions, rather than acting as a rigid framework for regions of liquid electrolyte. C1 UNIV ROME,DEPT CHEM,I-185 ROME,ITALY. USA,EPSD,RES LAB,FT MONMOUTH,NJ 07703. RP STALLWORTH, PE (reprint author), CUNY HUNTER COLL,DEPT PHYS,NEW YORK,NY 10021, USA. RI Croce, Fausto/J-8193-2012 NR 15 TC 36 Z9 36 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-2738 J9 SOLID STATE IONICS JI Solid State Ion. PD OCT PY 1994 VL 73 IS 1-2 BP 119 EP 126 DI 10.1016/0167-2738(94)90271-2 PG 8 WC Chemistry, Physical; Physics, Condensed Matter SC Chemistry; Physics GA PL040 UT WOS:A1994PL04000015 ER PT J AU SIMEONSSON, JB SAUSA, RC AF SIMEONSSON, JB SAUSA, RC TI TRACE DETECTION OF AMBIENT BROMINATED COMPOUNDS BY LASER-INDUCED PHOTOFRAGMENTATION FRAGMENT DETECTION SPECTROMETRY SO SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY LA English DT Article ID ENHANCED MULTIPHOTON IONIZATION; EXCITED STIMULATED-EMISSION; SOUTH POLAR SEA; ANTARCTIC ATMOSPHERE; INDUCED FLUORESCENCE; 2-PHOTON EXCITATION; METHYL-IODIDE; ATOMIC OXYGEN; RF PLASMAS; CL AB Studies have been performed to evaluate the analytical capabilities of a novel, one color, laser-induced photofragmentation/fragment detection technique for the detection of ambient brominated compounds. Laser radiation at 260.634 nm is used to both fragment the brominated compounds and excite the characteristic Br atom photofragment via its two-photon 4p(4)5p D-4(3/2)0<--4p(5 2) P-3/2(0) transition. Detection is accomplished by either (2 + 1) resonance-enhanced multiphoton ionization (REMPI), or by laser-induced fluorescence (LIF) or stimulated emission (SE) from the 4p(4)5p D-4(3/2)0-->4p(4)5s P-4(5/2,3/2) transitions at 814 and 751 nm, respectively. The SE signal is coaxial to the laser beam and is approximately two orders of magnitude greater than the LIF signal at 844 nm. Measurements are performed in a photolysis cell at total pressures of 1-760 Torr. For REMPI detection, total (nonselective) ion collection is employed using a miniature pair of electrodes. The absorption cross section of the two-photon 4p(4)5p D-4(3/2)0<--4p(5) P-3/2(0) transition is estimated to be 1.8 x 10(-45)cm(4)s and limits of detection in the ppb are obtained for CH3Br, CHBr3, and CHClBr2. C1 USA,RES LAB,AMSRL,WT PC,ABERDEEN PROVING GROUND,MD 21005. NR 25 TC 2 Z9 2 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0584-8547 J9 SPECTROCHIM ACTA B JI Spectroc. Acta Pt. B-Atom. Spectr. PD OCT-DEC PY 1994 VL 49 IS 12-14 BP 1545 EP 1555 DI 10.1016/0584-8547(94)80129-0 PG 11 WC Spectroscopy SC Spectroscopy GA QD364 UT WOS:A1994QD36400032 ER PT J AU CANCIO, LC WORTHAM, WG ZIMBA, F AF CANCIO, LC WORTHAM, WG ZIMBA, F TI PERITONEAL-DIALYSIS TO INDUCE HYPOTHERMIA IN A HEAD-INJURED PATIENT - CASE-REPORT SO SURGICAL NEUROLOGY LA English DT Note DE BRAIN INJURIES; HYPOTHERMIA, INDUCED; PERITONEAL DIALYSIS ID INTRACRANIAL-PRESSURE; HEMODIALYSIS; TRAUMA; LAVAGE; MANAGEMENT AB Hypothermia is of proven benefit in cerebral ischemia, and may be of benefit in blunt head injury. Peritoneal dialysis is a fast, effective method of inducing generalized hypothermia. A case is reported in which peritoneal dialysis was used to induce mild hypothermia (34.5-36-degrees-C) in a patient who sustained a severe head injury, with intracranial hypertension unresponsive to hyperventilation, osmotic diuresis, and barbiturate coma. Hypothermia was associated with prompt control of temperature and intracranial pressure. Peritoneal dialysis is a useful method for inducing hypothermia in the blunt head-injured patient. RP CANCIO, LC (reprint author), BROOKE ARMY MED CTR,GEN SURG SERV,FT SAM HOUSTON,TX 78234, USA. NR 37 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0090-3019 J9 SURG NEUROL JI Surg. Neurol. PD OCT PY 1994 VL 42 IS 4 BP 303 EP 307 DI 10.1016/0090-3019(94)90397-2 PG 5 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA PR330 UT WOS:A1994PR33000006 PM 7974124 ER PT J AU SRINIVASAN, R HALL, RR WILSON, WD LOEHLE, WD ALLBEE, DC AF SRINIVASAN, R HALL, RR WILSON, WD LOEHLE, WD ALLBEE, DC TI ULTRAVIOLET-LASER IRRADIATION OF THE POLYIMIDE, PMDA-ODA (KAPTON(TM)), TO YIELD A PATTERNABLE, POROUS, ELECTRICALLY CONDUCTING CARBON NETWORK SO SYNTHETIC METALS LA English DT Note DE IRRADIATION; POLYIMIDE; KAPTON(TM); CARBON NETWORK ID GLASSY-CARBON; FILMS; RADIATION; POLYMERS AB A beam of continuous-wave ultraviolet (275-363 nm) laser radiation, when focused to a spot such that its intensity is 10-100 kW/cm2, can be used to write a conducting pattern at speeds up to 90 cm/s on the surface of a film of polyimide, PMDA-ODA (Kapton(TM)). Analytical data show that the polyimide loses principally CO, CO2, C2H2 and HCN to give a black material that has C, 96.45, H, 0.29 and N, 2.85%. The product is very light (density about 0.1 g/cm3), porous and has an electrical conductivity of 20-25 S/cm. By the use of appropriate software, conducting patterns have been produced as lines of width as narrow as 15 mum or as uniform areas of up to 2 cm2. Free-standing filaments of the material have also been made. The conductivities of these specimens have not degraded over a period of several months in an ambient atmosphere. Raman spectra of the black material which was produced by raster scanning the laser beam over a PMDA-ODA surface show that the material is predominantly a 'glassy' carbon which is highly crystalline but with small crystallites. C1 US MIL ACAD,PHOTON RES CTR,W POINT,NY 10996. US MIL ACAD,DEPT CHEM,W POINT,NY 10996. RP SRINIVASAN, R (reprint author), UVTECH ASSOCIATES,98 CEDAR LANE,OSSINING,NY 10562, USA. NR 23 TC 19 Z9 19 U1 3 U2 15 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0379-6779 J9 SYNTHETIC MET JI Synth. Met. PD OCT PY 1994 VL 66 IS 3 BP 301 EP 307 DI 10.1016/0379-6779(94)90082-5 PG 7 WC Materials Science, Multidisciplinary; Physics, Condensed Matter; Polymer Science SC Materials Science; Physics; Polymer Science GA PN692 UT WOS:A1994PN69200016 ER PT J AU ROBINSON, MC AF ROBINSON, MC TI TO RECLAIM A DIVIDED WEST - WATER, LAW, AND PUBLIC-POLICY, 1848-1902 - PISANI,DJ SO TECHNOLOGY AND CULTURE LA English DT Book Review RP ROBINSON, MC (reprint author), USA,CORPS ENGINEERS,MISSISSIPPI RIVER COMMISS,VICKSBURG,MS 39180, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0040-165X J9 TECHNOL CULT JI Technol. Cult. PD OCT PY 1994 VL 35 IS 4 BP 871 EP 872 DI 10.2307/3106513 PG 2 WC History & Philosophy Of Science SC History & Philosophy of Science GA QH652 UT WOS:A1994QH65200010 ER PT J AU CHAFFIN, DJ GIANGERUSO, EA BABCOCK, JG HESS, JR AF CHAFFIN, DJ GIANGERUSO, EA BABCOCK, JG HESS, JR TI MILITARY BLOOD-DONORS, TRANSFUSION TRANSMISSIBLE DISEASE MARKERS, AND THE SAFETY OF THE MILITARY BLOOD-SUPPLY SO TRANSFUSION LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC BLOOD BANKS PI BETHESDA PA 8101 GLENBROOK RD, BETHESDA, MD 20814-2749 SN 0041-1132 J9 TRANSFUSION JI Transfusion PD OCT PY 1994 VL 34 IS 10 SU S BP S15 EP S15 PG 1 WC Hematology SC Hematology GA PM339 UT WOS:A1994PM33900060 ER PT J AU CROWELL, MC HERSHEY, JN SALATA, KF AF CROWELL, MC HERSHEY, JN SALATA, KF TI THE EFFECT OF IRRADIATION ON RED-BLOOD-CELL ANTIGEN DENSITIES - A FLOW CYTOMETRIC ANALYSIS SO TRANSFUSION LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER ASSOC BLOOD BANKS PI BETHESDA PA 8101 GLENBROOK RD, BETHESDA, MD 20814-2749 SN 0041-1132 J9 TRANSFUSION JI Transfusion PD OCT PY 1994 VL 34 IS 10 SU S BP S21 EP S21 PG 1 WC Hematology SC Hematology GA PM339 UT WOS:A1994PM33900083 ER PT J AU MCLEOD, DG AF MCLEOD, DG TI DYNAMIC MAGNETIC-RESONANCE-IMAGING OF THE CONTRALATERAL TESTIS IN PATIENTS WITH MALIGNANT-TUMOR OF THE TESTIS - COMMENT SO UROLOGY LA English DT Note RP MCLEOD, DG (reprint author), GEORGE WASHINGTON UNIV,WALTER REED ARMY MED CTR,UNIFORMED SERV HLTH SCI,UROL SERV,WASHINGTON,DC 20307, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD OCT PY 1994 VL 44 IS 4 BP 547 EP 547 DI 10.1016/S0090-4295(94)80055-3 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA PK421 UT WOS:A1994PK42100017 ER PT J AU FERNANDEZ, E MOUL, JW FOLEY, JP COLON, E MCLEOD, DG AF FERNANDEZ, E MOUL, JW FOLEY, JP COLON, E MCLEOD, DG TI RETROPERITONEAL IMAGING WITH 3RD AND 4TH GENERATION COMPUTED AXIAL-TOMOGRAPHY IN CLINICAL STAGE-I NONSEMINOMATOUS GERM-CELL TUMORS SO UROLOGY LA English DT Article ID TESTICULAR CANCER; METASTATIC DISEASE; EXPECTANT THERAPY; TESTIS TUMORS; SURVEILLANCE; CT; LYMPHOGRAPHY; LYMPHANGIOGRAPHY; HISTOPATHOLOGY; ORCHIDECTOMY AB Objectives. To examine the accuracy rate of abdominal staging using third and fourth generation computed tomography (CT) scanning in clinical Stage I testicular nonseminoma patients. Methods. Between January 1985 and August 1993, 57 patients presented to our center with clinical Stage I testicular nonseminoma. Retroperitoneal computed tomographic staging studies were interpreted to be normal preoperatively in the entire group. In addition, tumor marker values were normal or returned to normal postorchiectomy within the appropriate half-life intervals. All patients were subjected to radical or modified retroperitoneal lymph node dissection (19% and 72%, respectively). Original abdominal CT scans (preretroperitoneal lymph node dissection) were available for blinded retrospective re-review in 16 cases (7 pathologic Stage II, 9 pathologic Stage I). Results. Nineteen of 57 (33%) patients were upstaged at surgery including 6 patients (11%) who demonstrated II B volume disease. Third and fourth generation CT scanning of the retroperitoneum yielded a 66% accuracy rate in this population. Six out of 7 pathologic Stage II pre-lymph node dissection abdominal CT scans that were available for blinded re-review revealed nonpathologic nodes by size criteria in the primary landing zone for the corresponding original tumor. Conclusions. Our data suggests that for clinical Stage I nonseminoma in the 1985 to 1993 era, undue reliance was placed on a less than ideal staging test. The 33% false-negative rate reported showed no improvement over earlier reports and reaffirms concern for relying solely on third or fourth generation CT imaging of the retroperitoneum in the staging of clinical Stage I nonseminomatous germ cell tumor (NSGCT) patients. The presence of any number of lymph nodes in the expected primary landing zone, regardless of size, should raise serious suspicion for occult nodal disease. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. NR 36 TC 50 Z9 52 U1 1 U2 1 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD OCT PY 1994 VL 44 IS 4 BP 548 EP 552 DI 10.1016/S0090-4295(94)80056-1 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA PK421 UT WOS:A1994PK42100018 PM 7941194 ER PT J AU TRETTIN, CC AUST, WM DAVIS, MM WEAKLEY, AS WISNIEWSKI, J AF TRETTIN, CC AUST, WM DAVIS, MM WEAKLEY, AS WISNIEWSKI, J TI WETLANDS OF THE INTERIOR SOUTHEASTERN UNITED-STATES - CONFERENCE SUMMARY STATEMENT SO WATER AIR AND SOIL POLLUTION LA English DT Editorial Material AB The wetland resources in the southern United States are diverse, being characterized by bottomland hardwoods, forested riparian zones, swamps, marshes, bogs, and fens. Recognizing the importance of the wetland resource, the need to develop information on the diversity of wetland types, and the evolving public debate regarding the protection and management of wetlands, this conference was organized to (1) provide a forum for the presentation and discussion of current research and information on wetland ecosystems, (2) to develop a basis on which to improve wetland conservation and management, (3) to provide a forum to encourage collaboration in the study and management of wetland resources, and (4) to suggest actions that would benefit wetland conservation and management. Twenty-three invited technical papers and three working group sessions addressed topics encompassing the full spectrum of wetland issues, including resource status, ecological and hydrological processes, management and conservation, and restoration and creation. Major findings discussed at the conference included the need to distinguish between functions and values, the development of a hydrogeomorphic classification system for assessing wetland functions, and assessment methodologies for planning and implementing effective wetland restoration projects. Papers summarizing the current understanding of wetland soil and vegetation processes in the region highlighted the important role wetlands play in landscape function, yet the understanding of those processes is incomplete. Insights developed from the study of wetlands in the interior southeastern United States have widespread applicability to other regions because of similarities in hydrogeomorphic setting and vegetation communities, and the management and conservation issues. C1 OAK RIDGE NATL LAB,DIV ENVIRONM SCI,OAK RIDGE,TN 37831. VIRGINIA POLYTECH INST & STATE UNIV,DEPT FORESTRY,BLACKSBURG,VA 24061. USA,CORPS ENGINEERS,DIV ECOL RES,WATERWAYS EXPT STN,VICKSBURG,MS 39180. N CAROLINA NAT HERITAGE PROGRAM,RALEIGH,NC 27611. WISNIEWSKI & ASSOCIATES INC,FALLS CHURCH,VA 22043. NR 15 TC 3 Z9 3 U1 3 U2 5 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0049-6979 J9 WATER AIR SOIL POLL JI Water Air Soil Pollut. PD OCT PY 1994 VL 77 IS 3-4 BP 199 EP 205 DI 10.1007/BF00478418 PG 7 WC Environmental Sciences; Meteorology & Atmospheric Sciences; Water Resources SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences; Water Resources GA QD818 UT WOS:A1994QD81800003 ER PT J AU WAKELEY, JS AF WAKELEY, JS TI IDENTIFICATION OF WETLANDS IN THE SOUTHERN APPALACHIAN REGION AND THE CERTIFICATION OF WETLAND DELINEATORS SO WATER AIR AND SOIL POLLUTION LA English DT Article; Proceedings Paper CT Southern-Appalachian-Man-and-the-Biosphere (SAMAB) Conference on Wetland Ecology, Management, and Conservation CY SEP 28-30, 1993 CL KNOXVILLE, TN SP SO APPALACHIAN MAN & BIOSPHERE, OAK RIDGE NATL LAB, ENVIRONM SCI DIV, TENNESSEE VALLEY AUTHORITY, USDA, FOREST SERV AB According to the Corps of Engineers Wetlands Delineation Manual, wetlands are identified by the presence of field indicators of hydrophytic vegetation, hydric soils, and wetland hydrology. In the southern Appalachian region, situations that present problems for wetland delineators include (1) wetlands developed on recently deposited alluvial soils that may show little evidence of hydric conditions, (2) areas occupied by FAG-dominated plant communities, (3) wetlands affected by past or present drainage practices, (4) man-induced wetlands that may lack certain wetland field indicators, and (5) hydric soil units that are too small or narrow to be delineated separately on soil survey map sheets. In March 1993, under direction of Section 307(e) of the Water Resources Development Act of 1990, the Corps of Engineers initiated a Wetland Delineator Certification Program. A 1-year demonstration program has recently ended in Maryland, Florida, and Washington, with nationwide implementation scheduled for later in 1994. This voluntary program is designed to increase the quality of wetland delineations submitted with Section 404 permit applications, and reduce processing time by reducing the need for extensive field verification of wetland boundaries. RP WAKELEY, JS (reprint author), USA,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 7 TC 2 Z9 2 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0049-6979 J9 WATER AIR SOIL POLL JI Water Air Soil Pollut. PD OCT PY 1994 VL 77 IS 3-4 BP 217 EP 226 DI 10.1007/BF00478420 PG 10 WC Environmental Sciences; Meteorology & Atmospheric Sciences; Water Resources SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences; Water Resources GA QD818 UT WOS:A1994QD81800005 ER PT J AU DAVIS, MM AF DAVIS, MM TI DECISION SEQUENCE FOR FUNCTIONAL WETLANDS RESTORATION SO WATER AIR AND SOIL POLLUTION LA English DT Article; Proceedings Paper CT Southern-Appalachian-Man-and-the-Biosphere (SAMAB) Conference on Wetland Ecology, Management, and Conservation CY SEP 28-30, 1993 CL KNOXVILLE, TN SP SO APPALACHIAN MAN & BIOSPHERE, OAK RIDGE NATL LAB, ENVIRONM SCI DIV, TENNESSEE VALLEY AUTHORITY, USDA, FOREST SERV ID HABITAT AB As wetland functions are being mote clearly evaluated, demand is increasing for the ability to mitigate for specific wetland functions that have been degraded. When wetland restoration project goals specify functions, success of the project depends heavily on proper guidance for project siting design, implementation, and monitoring. A decision sequence is presented for wetland restoration projects to help achieve functional replacement. This methodology incorporates site selection and design features for specified wetland functions into three phases of a project planning decision sequence. The first phase, site selection, situates a wetland where there is the potential to perform a function Phases two and three, the incorporation of functional design features into design criteria and project plan development, focus on the optimization of the functional capacity of a site. An example is given of how a wetland restoration project planning team can consider enhancing vegetation diversity during the project plan development phase to achieve a goal of improved wildlife habitat. RP DAVIS, MM (reprint author), USA,ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 23 TC 6 Z9 6 U1 0 U2 6 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0049-6979 J9 WATER AIR SOIL POLL JI Water Air Soil Pollut. PD OCT PY 1994 VL 77 IS 3-4 BP 497 EP 511 DI 10.1007/BF00478435 PG 15 WC Environmental Sciences; Meteorology & Atmospheric Sciences; Water Resources SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences; Water Resources GA QD818 UT WOS:A1994QD81800020 ER PT J AU CHOI, KK LEE, CY TIDROW, MZ CHANG, WH GUNAPALA, SD AF CHOI, KK LEE, CY TIDROW, MZ CHANG, WH GUNAPALA, SD TI PERFORMANCE ASSESSMENT OF QUANTUM-WELL INFRARED PHOTODETECTORS SO APPLIED PHYSICS LETTERS LA English DT Article ID HOT-ELECTRON TRANSISTOR AB The performance of GaAs/AlGaAs quantum well infrared photodetectors specified in terms of background limited temperature T-b and specific detectivity D* has been calculated based on realistic detector parameters. It is found that for a detector with an external quantum efficiency eta of 6.9%, T-b is 76 K for a cutoff wavelength of 10 mu m. This value of T-b agrees with the recent experimental result and is significantly higher than the previous estimation given by M. A. Kinch and A. Yariv [Appl. Phys. Lett. 55, 2093 (1989)]. if eta is unity, the projected T-b can be as high as 88 K with a D* of 2.2X10(11) cm root Hz/W. For a lower temperature operation, D* increases to 7.5X10(11) cm root Hz/W at 77 K, comparable to that of a HgCdTe detector. C1 CALTECH,JET PROP LAB,PASADENA,CA 91109. RP CHOI, KK (reprint author), USA,RES LAB,EPSD,FT MONMOUTH,NJ 07703, USA. RI Choi, Kwong-Kit/K-9205-2013 NR 14 TC 8 Z9 8 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 26 PY 1994 VL 65 IS 13 BP 1703 EP 1705 DI 10.1063/1.112891 PG 3 WC Physics, Applied SC Physics GA PH332 UT WOS:A1994PH33200034 ER PT J AU REBERT, NW AF REBERT, NW TI SYNTHESIS OF O-(2'-BROMOPROPIONYL)GLYCOLIC ACID AND ITS POLYMERIZATION - SYNTHESIS OF AN ALTERNATING LACTIC AND GLYCOLIC ACID COPOLYMER SO MACROMOLECULES LA English DT Article ID DEGRADATION RATES AB Poly(lactylglycolic acid) (6) polymer was synthesized by the condensation polymerization of O-(2'-bromopropionyl)glycolic acid (5). This is an alternating version of poly(lactic acid-co-glycolic acid) (50:50). Molecular weights as high as 66 000 were prepared. The triethylammonium salt of this acid (5) was formed, and the resulting anion displaced bromine to form the polyester, similar to the formation of poly(glycolic acid) by Pinkus and Subramanyam.4 This is an unusual method of condensation polymerization, since a hydrobromic acid equivalent is lost instead of water. The method may be applicable to the formation of other polyesters. An improved method of synthesis of O-(2'-bromopropionyl)glycolic acid (5) is also described using a proton as a protecting group. RP REBERT, NW (reprint author), TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859, USA. NR 13 TC 14 Z9 16 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD SEP 26 PY 1994 VL 27 IS 20 BP 5533 EP 5535 DI 10.1021/ma00098a003 PG 3 WC Polymer Science SC Polymer Science GA PJ324 UT WOS:A1994PJ32400003 ER PT J AU HAYES, S GREBOGI, C OTT, E MARK, A AF HAYES, S GREBOGI, C OTT, E MARK, A TI EXPERIMENTAL CONTROL OF CHAOS FOR COMMUNICATION SO PHYSICAL REVIEW LETTERS LA English DT Article ID OSCILLATOR; ATTRACTOR; CRISES AB The use of chaos to transmit information is demonstrated experimentally. The symbolic dynamics of a chaotic electrical oscillator is controlled to carry a prescribed message by use of extremely small perturbing current pulses. C1 UNIV MARYLAND,DEPT PHYS & ASTRON,COLLEGE PK,MD 20742. UNIV MARYLAND,PLASMA RES LAB,COLLEGE PK,MD 20742. UNIV MARYLAND,INST PHYS SCI & TECHNOL,COLLEGE PK,MD 20742. UNIV MARYLAND,DEPT MATH,COLLEGE PK,MD 20742. UNIV MARYLAND,DEPT ELECT ENGN,COLLEGE PK,MD 20742. UNIV MARYLAND,SYST RES INST,COLLEGE PK,MD 20742. RP HAYES, S (reprint author), USA,RES LAB,ADELPHI,MD 20783, USA. RI O, E/F-1630-2015 NR 18 TC 224 Z9 225 U1 0 U2 13 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD SEP 26 PY 1994 VL 73 IS 13 BP 1781 EP 1784 DI 10.1103/PhysRevLett.73.1781 PG 4 WC Physics, Multidisciplinary SC Physics GA PH256 UT WOS:A1994PH25600012 ER PT J AU MANKA, AS DOWLING, JP BOWDEN, CM FLEISCHHAUER, M AF MANKA, AS DOWLING, JP BOWDEN, CM FLEISCHHAUER, M TI PIEZOPHOTONIC SWITCHING DUE TO LOCAL-FIELD EFFECTS IN A COHERENTLY PREPARED MEDIUM OF 3-LEVEL ATOMS SO PHYSICAL REVIEW LETTERS LA English DT Article ID ELECTROMAGNETICALLY INDUCED TRANSPARENCY; QUANTUM COHERENCE; 2-LEVEL ATOMS; INVERSION; INDEX; INTERFERENCE; ENHANCEMENT; REFRACTION; LASER; RESONANCES AB We study the effect of near dipole-dipole interactions on the electric susceptibility of a coherently prepared three-level Lambda system. We discuss the influence of atomic nonlinearities on the recently predicted enhancement of the absorptionless index of refraction and inversionless gain due to local field effects [J.P. Dowling and C. M. Bowden, Phys. Rev. Lett. 70, 1421 (1993)] and predict a density dependent, or piezophotonic, switching between absorption and amplification. C1 UNIV MUNICH,DEPT PHYS,D-80333 MUNICH,GERMANY. RP MANKA, AS (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,AMSMI RD WS ST,WEAPONS SCI DIRECTORATE,REDSTONE ARSENAL,REDSTONE ARSENAL,AL 35898, USA. RI Fleischhauer, Michael/G-6716-2011; DOWLING, JONATHAN/L-2749-2013 NR 26 TC 59 Z9 60 U1 1 U2 3 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD SEP 26 PY 1994 VL 73 IS 13 BP 1789 EP 1792 DI 10.1103/PhysRevLett.73.1789 PG 4 WC Physics, Multidisciplinary SC Physics GA PH256 UT WOS:A1994PH25600014 ER PT J AU RICE, BM CHABALOWSKI, CF AF RICE, BM CHABALOWSKI, CF TI AB-INITIO POTENTIAL-ENERGY SURFACE FOR H+OCS REACTIONS - EXTENDED BASIS-SETS AND CORRELATION TREATMENT SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID GAUSSIAN-BASIS SETS; ELECTRON CORRELATION-ENERGY; MOLECULAR-ORBITAL METHODS; PERTURBATION-THEORY; CONFIGURATION-INTERACTION; CARBONYL SULFIDE; ATOMIC-HYDROGEN; WAVE-FUNCTIONS; 1ST-ROW; ERRORS AB Ab initio calculations are presented for the potential energy surface (PES) of H + OCS. The two triple-zeta AO basis sets used are the 6-311+G(2df,2p) and aug-cc-pVTZ. The highest levels of correlation employed are MP4 and QCISD(T) starting with UHF zeroth-order wave functions. There are two major reaction channels on the PES: reaction I is H(S-2) + OCS((1) Sigma) --> OH((II)-I-2) + CS((1) Sigma), and reaction II is H(S-2) + OCS((1) Sigma) --> SH((II)-I-2) + CO((1) Sigma). Multiple pathways leading from reactants to (I) and (II) were determined. Results of this study substantiate findings from an earlier quantum chemical study using a lower level of theory, including (1) the existence of 12 transition states and six stable four-body intermediates; (2) the qualitative description of the PES; i.e., geometries, relative barriers, and well depths are similar to those in the earlier study; and (3) the entrance channel transition states leading to (II) are tight, as suggested by experiment. The results presented here also support the explanations of observed product energy distributions for (I) and (II) based on the earlier ab initio study. An additional transition state connecting the cis-HOCS and cis-HSCO minima was located, confirming a previous suggestion that reaction II could result from hydrogen migration after HOCS formation. The size of the barrier to hydrogen migration on this PES, however, indicates that it is a high-energy reaction. The low-energy pathway leading to (II) is through direct formation of HSCO. The current results show a substantial improvement in the quantitative agreement with experiment over the previously calculated values. Our best calculations predict reaction enthalpies for (I) and (II) to be 57.3 and -11.5 kcal/mol, respectively, well within the uncertainty of the experimental data. The measured activation energy for (II), which includes all dynamic and quantum effects such as tunneling, is 3.9 kcal/mol, Our best theoretical value for the lowest energy barrier leading to (II) is 5.7 kcal/mol (including zero-point corrections). We emphasize that corrections due to tunneling are not included in this value. RP RICE, BM (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 37 TC 12 Z9 12 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD SEP 22 PY 1994 VL 98 IS 38 BP 9488 EP 9497 DI 10.1021/j100089a022 PG 10 WC Chemistry, Physical SC Chemistry GA PH559 UT WOS:A1994PH55900022 ER PT J AU SLACK, MC KIRBY, WC TOWBIN, JA DENFIELD, SW GRIFKA, RR BRICKER, JT OTT, DA FRAZIER, OH AF SLACK, MC KIRBY, WC TOWBIN, JA DENFIELD, SW GRIFKA, RR BRICKER, JT OTT, DA FRAZIER, OH TI STENTING OF THE DUCTUS-ARTERIOSUS IN HYPOPLASTIC LEFT-HEART SYNDROME AS AN AMBULATORY BRIDGE TO CARDIAC TRANSPLANTATION SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Note ID DISEASE C1 PRINCE GEORGES GEN HOSP & MED CTR,DEPT PEDIAT,CHEVERLY,MD. BAYLOR COLL MED,LILLIE FRANK ABERCROMBIE SECT PEDIAT CARDIOL,HOUSTON,TX. TEXAS CHILDRENS HOSP,HOUSTON,TX. TEXAS HEART INST,HOUSTON,TX. ST LUKES EPISCOPAL HOSP,HOUSTON,TX. RP SLACK, MC (reprint author), WALTER REED ARMY MED CTR,SERV CARDIOL,ROOM 4A,WASHINGTON,DC 20307, USA. NR 5 TC 7 Z9 7 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD SEP 15 PY 1994 VL 74 IS 6 BP 636 EP 637 DI 10.1016/0002-9149(94)90764-1 PG 2 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA PF094 UT WOS:A1994PF09400026 PM 7521119 ER PT J AU LEAVITT, RP BRADSHAW, JL AF LEAVITT, RP BRADSHAW, JL TI MOLECULAR-BEAM-EPITAXIAL GROWTH AND CHARACTERIZATION OF HIGH-QUALITY ALLOYS AND MULTIPLE-QUANTUM WELLS ON INP SUBSTRATES USING A POST-EVAPORATION-HEATED ARSENIC SOURCE SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID PHOTOLUMINESCENCE EXCITATION SPECTROSCOPY; ELECTRIC-FIELD; ABSORPTION-SPECTROSCOPY; MATERIAL PARAMETERS; STARK LOCALIZATION; OPTICAL-PROPERTIES; MU-M; AL0.48IN0.52AS; GAAS; HETEROSTRUCTURES AB We report the growth of high-quality As-based ternary and quaternary alloys lattice matched to InP using a valved arsenic source that can post-heat the As beam after evaporation. We find that the optimum group-V-to-group-III beam-equivalent pressure ratio for growth of (In,Ga)As alloys using this source is considerably lower than values reported previously for growth using conventional As-4 sources. Consequently, high-quality (In,Ga)As, (In,Al)As, and (In,Al,Ga)As alloys (and quantum wells made from these alloys) can be grown under the same growth conditions, i.e., substrate temperatures between about 525 degrees C and 540 degrees C and V/III pressure ratios between 10:1 and 15:1. Thick-film alloys and multiple-quantum-well structures grown under these conditions show superior structural and optical quality. Strong excitonic features are observed in the room-temperature absorption spectra of a number of multiple-quantum-well structures with well widths ranging from 30 Angstrom to 170 degrees. Calculations of the exciton transition energies using a simple empirical two-band model are in excellent agreement with experiment, even for a structure containing quantum wells in tensile strain in which the ordering of ground-state light- and heavy-hole excitons is reversed. The optical absorption spectrum of a 50-Angstrom -period (In,Ga)As/ (In,Al)As superlattice shows room-temperature excitons involving electronic states at both the bottom and top of the minibands. Exciton line widths for these quantum-well structures, measured using low-temperature photoluminescence, are consistent with the limits imposed by random alloy fluctuations. We tentatively explain the lower optimum V/III pressure ratio for growth of (In,Ga)As in terms of the increase in kinetic energy of Asq molecules (compared with the kinetic energy of molecules from a conventional AS(4) source) and the consequent enhancement in the efficiency of dissociation of AS(4) molecules into As-2 molecules at the growing surface. RP LEAVITT, RP (reprint author), USA,RES LAB,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. RI Bradshaw, John/E-8330-2011 NR 45 TC 13 Z9 13 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 15 PY 1994 VL 76 IS 6 BP 3429 EP 3442 DI 10.1063/1.357473 PG 14 WC Physics, Applied SC Physics GA PJ117 UT WOS:A1994PJ11700030 ER PT J AU BHATT, AR KIM, KW STROSCIO, MA AF BHATT, AR KIM, KW STROSCIO, MA TI THEORETICAL CALCULATION OF LONGITUDINAL-OPTICAL-PHONON LIFETIME IN GAAS SO JOURNAL OF APPLIED PHYSICS LA English DT Note ID ZINCBLENDE STRUCTURE COMPOUNDS; LATTICE-DYNAMICS; RELAXATION; LASERS; MODEL AB The anharmonic decay of longitudinal-optical (LO) phonons in zinc-blende semiconductors has been studied. Based on an approach in which the anharmonic crystal potential is estimated using the theory of elasticity, the lifetime of LO phonons via emission of two acoustic phonons is calculated as a function of lattice temperature and phonon wave vector. Application of this model to bulk GaAs shows an excellent agreement with available experimental data. Since the parameters employed in the model can be obtained experimentally, the approach provides a useful tool to investigate LO-phonon lifetimes in semiconductors. C1 USA, RES OFF, RES TRIANGLE PK, NC 27709 USA. RP N CAROLINA STATE UNIV, DEPT ELECT & COMP ENGN, RALEIGH, NC 27695 USA. NR 21 TC 34 Z9 35 U1 0 U2 3 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 15 PY 1994 VL 76 IS 6 BP 3905 EP 3907 DI 10.1063/1.358498 PG 3 WC Physics, Applied SC Physics GA PJ117 UT WOS:A1994PJ11700101 ER PT J AU ALEXANDER, MH GREGURICK, S DAGDIGIAN, PJ LEMIRE, GW MCQUAID, MJ SAUSA, RC AF ALEXANDER, MH GREGURICK, S DAGDIGIAN, PJ LEMIRE, GW MCQUAID, MJ SAUSA, RC TI POTENTIAL-ENERGY SURFACES FOR THE INTERACTION OF CH(X (2)PI,B (2)SIGMA(-)) WITH AR AND AN ASSIGNMENT OF THE STRETCH-BEND LEVELS OF THE ARCH(B) VAN-DER-WAALS MOLECULE SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID ROTATIONALLY INELASTIC-COLLISIONS; SHELL VANDERWAALS COMPLEXES; CONFIGURATION-INTERACTION CALCULATIONS; HIGH-RESOLUTION SPECTROSCOPY; LASER-INDUCED FLUORESCENCE; CLOSE-COUPLING APPROACH; PI-ELECTRONIC STATES; DIATOMIC MOLECULE; OH-AR; STRUCTURELESS TARGET AB New multireference, configuration-interaction potential energy surfaces are reported for the interaction of Ar with the CH radical in its ground (X (2) Pi) and second excited (B (2) Sigma(-)) electronic states. These potential energy surfaces are then used in an adiabatic analysis of the rovibronic levels of the ArCH(X) and ArCH(B) van der Waals complexes. A qualitative discussion of the expected features in the B <-- X electronic spectrum of ArCH is presented, and these are compared with the experimental spectrum reported earlier by Lemire et al. [J. Chem. Phys. 99, 91 (1993)]. C1 JOHNS HOPKINS UNIV,DEPT CHEM,BALTIMORE,MD 21218. USA,BALLIST RES LAB,AMSRL WT PC,ABERDEEN PROVING GROUND,MD 21005. RP ALEXANDER, MH (reprint author), UNIV MARYLAND,DEPT CHEM & BIOCHEM,COLLEGE PK,MD 20742, USA. NR 81 TC 54 Z9 54 U1 0 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD SEP 15 PY 1994 VL 101 IS 6 BP 4547 EP 4560 DI 10.1063/1.467442 PG 14 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA PF943 UT WOS:A1994PF94300008 ER PT J AU HE, J IAFRATE, GJ AF HE, J IAFRATE, GJ TI MULTIBAND THEORY OF BLOCH ELECTRON DYNAMICS IN A HOMOGENEOUS ELECTRIC-FIELD SO PHYSICAL REVIEW B LA English DT Article ID NEGATIVE DIFFERENTIAL VELOCITY; SUBMILLIMETER-WAVE EMISSION; SEMICONDUCTOR SUPERLATTICE; GAAS/ALAS SUPERLATTICES; QUANTUM TRANSPORT; OSCILLATIONS AB A multiband theory of Bloch electron dynamics in a uniform electric field of arbitrary strength is presented. In this formalism, the electric field is described through the use of the vector potential. Multiband coupling is treated through the use of the Wigner-Weisskopf approximation, thus allowing for a Bloch-electron transition out of the initial band due to the power absorbed by the electric field; also, the approximation insures conservation of total transition probability over the complete set of excited bands. The choice of the vector-potential gauge leads to a natural set of extended time-dependent basis functions for describing Bloch-electron dynamics in a homogeneous electric field; an associated basis set of localized, electric-field-dependent Wannier and related envelope functions are utilized in the analysis to demonstrate the inherent localization manifest in Bloch dynamics in the presence of relatively strong electric fields. From the theory, a generalized Zener tunneling time is derived in terms of the applied uniform electric field and the relevant band parameters; specific results are derived from the general theory using a nearest-neighbor tight-binding, multiband model, and are shown to have identical parametric dependence on electric field, but different, more realistic dependence on the appropriate bandstructure parameters than those of the well-known Kane and effective-mass two-band model. Further, the analysis shows an electric-field-enhanced broadening of the excited-state probability amplitudes, thus resulting in spatial lattice delocalization and the onset of smearing of discrete, Stark-ladder, and band-to-band transitions due to the presence of the electric field. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP HE, J (reprint author), N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695, USA. NR 23 TC 9 Z9 9 U1 1 U2 3 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD SEP 15 PY 1994 VL 50 IS 11 BP 7553 EP 7566 DI 10.1103/PhysRevB.50.7553 PG 14 WC Physics, Condensed Matter SC Physics GA PJ437 UT WOS:A1994PJ43700040 ER PT J AU PIMENTA, PFP SARAIVA, EMB ROWTON, E MODI, GB GARRAWAY, LA BEVERLEY, SM TURCO, SJ SACKS, DL AF PIMENTA, PFP SARAIVA, EMB ROWTON, E MODI, GB GARRAWAY, LA BEVERLEY, SM TURCO, SJ SACKS, DL TI EVIDENCE THAT THE VECTORIAL COMPETENCE OF PHLEBOTOMINE SAND FLIES FOR DIFFERENT SPECIES OF LEISHMANIA IS CONTROLLED BY STRUCTURAL POLYMORPHISMS IN THE SURFACE LIPOPHOSPHOGLYCAN SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article ID DONOVANI LIPOPHOSPHOGLYCAN; GLYCOCONJUGATE; PAPATASI; MIDGUT AB Phlebotomine vectors can in some instances transmit only certain species of Leishmania. Comparison of a large number of vector/parasite pairs revealed that species-specific differences in vectorial competence were in every case directly correlated with the ability of promastigotes to attach to the sand-fly midgut, the variable outcomes of which were controlled by structural polymorphisms in the surface lipophosphoglycan (LPG) of the parasite. The ability of Phlebotomus papatasi to transmit only Leishmania major could be attributed to the unique, highly substituted nature of L. major LPG that provides for multiple terminally exposed beta-linked galactose residues for binding. While the relatively unsubstituted LPGs of other Leishmania species were unable to mediate promastigote attachment to P. papatasi, they could mediate binding to midguts of Phlebotomus argentipes, which was found to be a potentially competent vector for every Leishmania species examined. The data suggest that at least some phlebotomine vectors differ with respect to the parasite recognition sites which they express and that midgut adhesion is a sufficiently critical component of vectorial competence as to provide the evolutionary drive for LPG structural polymorphisms. C1 NIAID,IMMUNOL & CELL BIOL SECT,PARASIT DIS LAB,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115. UNIV KENTUCKY,MED CTR,DEPT BIOCHEM,LEXINGTON,KY 40536. RI Rowton, Edgar/A-4474-2012; Rowton, Edgar/A-1975-2011; OI Rowton, Edgar/0000-0002-1979-1485; Beverley, Stephen/0000-0001-5319-0811 FU NIAID NIH HHS [AI2964] NR 27 TC 134 Z9 137 U1 0 U2 6 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD SEP 13 PY 1994 VL 91 IS 19 BP 9155 EP 9159 DI 10.1073/pnas.91.19.9155 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA PG521 UT WOS:A1994PG52100087 PM 8090785 ER PT J AU CHENG, YY CEBE, P SCHREUDERGIBSON, H BLUHM, A YEOMANS, W AF CHENG, YY CEBE, P SCHREUDERGIBSON, H BLUHM, A YEOMANS, W TI CRYSTALLIZATION OF MONOTROPIC LIQUID-CRYSTALLINE POLYCARBONATES BASED ON A METHYL-STILBENE MESOGEN AND A METHYLENE-CONTAINING FLEXIBLE SPACER SO MACROMOLECULES LA English DT Article ID MAIN-CHAIN; CONFORMATIONAL ISOMERISM; THERMOTROPIC POLYETHERS; PHASE-TRANSITIONS; MELTING BEHAVIOR; ODD NUMBER; 1-(4-HYDROXYPHENYL)-2-(2-METHYL-4-HYDROXYPHENYL)ETHANE; POLYESTERS; POLYMERS; UNITS AB Crystallization behavior has been studied for a series of recently synthesized liquid crystalline polycarbonates1 based on a methyl-substituted stilbene mesogen and a methylene-containing flexible spacer. The stability of the nematic phase and its relationship to three-dimensional crystallinity were studied. Development of crystallinity was followed by isothermal and nonisothermal crystallization using differential scanning calorimetry (DSC) and polarizing optical microscopy. A monotropic liquid crystal phase is identified for these polycarbonates. The multiple melting endotherms seen in the heating scan are assigned to the melting of crystals forming either from the mesophase (melting at higher temperature) or from the isotropic phase (melting at lower temperature). The number, n, of -(CH2)- units in the flexible spacer affects the transition temperatures seen in the cooling and heating scans. Only a weak odd-even effect is seen in the upper melting of the heating scan from n = 5 to 8. In this range of spacer length, the region of stability of the liquid crystal phase seen in the cooling scan becomes smaller. When the length of the spacer becomes greater than that of the mesogen (n greater-than-or-equal-to 9), all the transition temperatures drop. C1 MIT,DEPT MAT SCI & ENGN,CAMBRIDGE,MA 02139. USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. NR 37 TC 13 Z9 13 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD SEP 12 PY 1994 VL 27 IS 19 BP 5440 EP 5448 DI 10.1021/ma00097a025 PG 9 WC Polymer Science SC Polymer Science GA PG449 UT WOS:A1994PG44900025 ER PT J AU JOHNSON, JL AF JOHNSON, JL TI PULSE-COUPLED NEURAL NETS - TRANSLATION, ROTATION, SCALE, DISTORTION, AND INTENSITY SIGNAL INVARIANCE FOR IMAGES SO APPLIED OPTICS LA English DT Article AB The linking-field neural network model of Eckhorn et al. [Neural Comput, 2, 293-307 (1990)] was introduced to explain the experimentally observed synchronous activity among neural assemblies in the cat cortex induced by feature-dependent visual activity. The model produces synchronous bursts of pulses from neurons with similar activity, effectively grouping them by phase and pulse frequency. It gives a basic new function: grouping by similarity. The synchronous bursts are obtained in the limit of strong linking strengths. The linking-field model in the limit of moderate-to-weak linking characterized by few if any multiple bursts is investigated. In this limit dynamic, locally periodic traveling waves exist whose time signal encodes the geometrical structure of a two-dimensional input image. The signal can be made insensitive to translation, scale, rotation, distortion, and intensity. The waves transmit information beyond the physical interconnect distance. The model is implemented in an optical hybrid demonstration system. Results of the simulations and the optical system are presented. RP JOHNSON, JL (reprint author), USA, MISSILE COMMAND, CTR RES DEV & ENGN, WEAPONS SCI DIRECTORATE, AMSMI RD WS PO, REDSTONE ARSENAL, AL 35898 USA. NR 19 TC 145 Z9 164 U1 1 U2 9 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD SEP 10 PY 1994 VL 33 IS 26 BP 6239 EP 6253 PG 15 WC Optics SC Optics GA PG458 UT WOS:A1994PG45800014 PM 20936043 ER PT J AU URBAN, JJ VONTERSCH, RL FAMINI, GR AF URBAN, JJ VONTERSCH, RL FAMINI, GR TI EFFECT OF FLUORINE SUBSTITUTION ON PHENOL ACIDITIES IN THE GAS-PHASE AND IN AQUEOUS-SOLUTION - A COMPUTATIONAL STUDY USING CONTINUUM SOLVATION MODELS SO JOURNAL OF ORGANIC CHEMISTRY LA English DT Article ID FREE-ENERGIES; MOLECULAR MECHANICS; PARAMETERS; EQUILIBRIA; AFFINITIES; POTENTIALS; PM3-SM3; BASES; RING; IONS AB The effect of fluorine substitution on the gas and aqueous phase acidity of the monofluorophenols has been investigated with a combination of computational techniques. The effects of aqueous solvation were included using the SM2, SM3, and GB/SA continuum solvation models. These solvation models produce calculated free energies of hydration that are in good agreement with the available experimental data and appear to be quite useful for the prediction of the solvent effects on the relative acidities of the fluorophenols with respect to phenol. A thorough analysis of the charge distribution in the gas and aqueous phases provides insight into the nature of the experimentally observed solvent attenuation of substituent effects for these compounds. While fluorine substitution increases the hydrophobicity of the phenols and phenoxides, the perturbation of ring charge density imparted by fluorine substitution is quite similar in the gas and aqueous phases. C1 USA,CTR DEV & ENGN,SCBRD,RTC,ABERDEEN PROVING GROUND,MD 21010. USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 42 TC 12 Z9 12 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3263 J9 J ORG CHEM JI J. Org. Chem. PD SEP 9 PY 1994 VL 59 IS 18 BP 5239 EP 5245 DI 10.1021/jo00097a027 PG 7 WC Chemistry, Organic SC Chemistry GA PF810 UT WOS:A1994PF81000027 ER PT J AU CHOI, KK AF CHOI, KK TI GENERALIZED RELATIONSHIP BETWEEN GAIN, NOISE, AND CAPTURE PROBABILITY OF QUANTUM-WELL INFRARED PHOTODETECTORS SO APPLIED PHYSICS LETTERS LA English DT Article AB We show that due to the discrete nature of multiple quantum well structures, the decay function of an energetic electron depends on the spatial extent of the electron wave function. As a result, the current gain of a quantum well infrared photodetector (QWIP) cannot be uniquely specified by the single well capture probability p(c). Specifically, for a given p(c) the current gain of an extended state electron is found to be larger than that of a localized electron. Consequently, for a typical QWIP, it is possible that the photocurrent gain is larger than the dark current gain, resulting in a reduction of dark current induced generation-recombination noise from its expected value. RP CHOI, KK (reprint author), USA,RES LAB,EPSD,FT MONMOUTH,NJ 07703, USA. RI Choi, Kwong-Kit/K-9205-2013 NR 7 TC 21 Z9 21 U1 0 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 5 PY 1994 VL 65 IS 10 BP 1266 EP 1268 DI 10.1063/1.112090 PG 3 WC Physics, Applied SC Physics GA PE880 UT WOS:A1994PE88000022 ER PT J AU SCALORA, M DOWLING, JP BOWDEN, CM BLOEMER, MJ AF SCALORA, M DOWLING, JP BOWDEN, CM BLOEMER, MJ TI OPTICAL LIMITING AND SWITCHING OF ULTRASHORT PULSES IN NONLINEAR PHOTONIC BAND-GAP MATERIALS SO PHYSICAL REVIEW LETTERS LA English DT Article AB We numerically investigate nonlinear propagation of ultrashort pulses in a one-dimensional photonic band gap structure. We find that, near the band edge, nonlinear effects cause a dynamical shift in the location of the band gap. We demonstrate that this nonlinear mechanism can induce intensity-dependent pulse transmission and reflections. In addition, pulse reshaping and pulse generation is observed. This phenomenon has important new applications in both optical limiting and optical switching. RP SCALORA, M (reprint author), USA,MISSILE COMMAND,AMSMI RD WS,CTR DEV & ENGN,REDSTONE ARSENAL,AL 35898, USA. RI DOWLING, JONATHAN/L-2749-2013 NR 11 TC 506 Z9 533 U1 4 U2 28 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD SEP 5 PY 1994 VL 73 IS 10 BP 1368 EP 1371 DI 10.1103/PhysRevLett.73.1368 PG 4 WC Physics, Multidisciplinary SC Physics GA PE727 UT WOS:A1994PE72700015 ER PT J AU BROWER, KL MYERS, SM EDWARDS, AH JOHNSON, NM VAN DE WALLE, CG POINDEXTER, EH AF BROWER, KL MYERS, SM EDWARDS, AH JOHNSON, NM VAN DE WALLE, CG POINDEXTER, EH TI ELECTRON-PARAMAGNETIC-RESONANCE OF MOLECULAR-HYDROGEN IN SILICON - COMMENT SO PHYSICAL REVIEW LETTERS LA English DT Note ID 111 SI-SIO2 INTERFACE; HYPERFINE INTERACTIONS; KINETICS; DEFECTS C1 UNIV N CAROLINA, DEPT ELECT ENGN, CHARLOTTE, NC 28223 USA. XEROX CORP, PALO ALTO RES CTR, PALO ALTO, CA 94304 USA. USA, RES LAB, ELECTR & POWER SOURCES DIRECTORATE, FT MONMOUTH, NJ 07703 USA. RP BROWER, KL (reprint author), SANDIA NATL LABS, ALBUQUERQUE, NM 87185 USA. RI Van de Walle, Chris/A-6623-2012 OI Van de Walle, Chris/0000-0002-4212-5990 NR 11 TC 12 Z9 12 U1 1 U2 2 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 EI 1079-7114 J9 PHYS REV LETT JI Phys. Rev. Lett. PD SEP 5 PY 1994 VL 73 IS 10 BP 1456 EP 1456 DI 10.1103/PhysRevLett.73.1456 PG 1 WC Physics, Multidisciplinary SC Physics GA PE727 UT WOS:A1994PE72700037 ER PT J AU MCQUAID, MJ LEMIRE, GW SAUSA, RC AF MCQUAID, MJ LEMIRE, GW SAUSA, RC TI BOUND-BOUND AR-NO A-X VIBRONIC TRANSITIONS - NEW MASS-RESOLVED 1+1 REMPI OBSERVATIONS SO CHEMICAL PHYSICS LETTERS LA English DT Article ID MULTIPHOTON IONIZATION SPECTROSCOPY; SHELL VANDERWAALS COMPLEXES; NITRIC-OXIDE; ROTATIONAL SPECTRA; MOLECULES; PHOTOELECTRON; DYNAMICS; ANGLE; STATE; OH AB The mass-resolved 1 + 1 REMPI spectra associated with bound-bound Ar-NO A-X vibronic transitions has been reinvestigated. The current results provide a basis for assigning the vibrationless Ar-NO A-X band origin, and establishing a refined upper limit for the A state dissociation energy (D0less-than-or-equal-to 43 cm-1). Assignments for bands associated with vibrationally excited A state levels are also proposed. RP MCQUAID, MJ (reprint author), USA,RES LAB,AMSRL,WT PC,ABERDEEN PROVING GROUND,MD 21005, USA. NR 32 TC 30 Z9 30 U1 2 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD SEP 2 PY 1994 VL 227 IS 1-2 BP 54 EP 60 DI 10.1016/0009-2614(94)00809-4 PG 7 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA PE835 UT WOS:A1994PE83500010 ER PT J AU MEKALANOS, JJ SADOFF, JC AF MEKALANOS, JJ SADOFF, JC TI CHOLERA VACCINES - FIGHTING AN ANCIENT SCOURGE SO SCIENCE LA English DT Editorial Material ID VIBRIO-CHOLERAE; HUMANS; TOXIN C1 WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. RP MEKALANOS, JJ (reprint author), HARVARD UNIV,SCH MED,DEPT MICROBIOL & MOLEC GENET,200 LONGWOOD AVE,BOSTON,MA 02115, USA. FU NIAID NIH HHS [AI-18045] NR 19 TC 28 Z9 30 U1 0 U2 0 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD SEP 2 PY 1994 VL 265 IS 5177 BP 1387 EP 1389 DI 10.1126/science.8073279 PG 3 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA PE733 UT WOS:A1994PE73300031 PM 8073279 ER PT J AU STONG, GC RAVAL, HB MARTIN, JW KAZRAGIS, RJ ENGHARDT, MH AF STONG, GC RAVAL, HB MARTIN, JW KAZRAGIS, RJ ENGHARDT, MH TI NODULAR SUBCUTANEOUS HISTOPLASMOSIS - A CASE-REPORT WITH DIAGNOSIS BY FINE-NEEDLE ASPIRATION BIOPSY SO ACTA CYTOLOGICA LA English DT Note DE HISTOPLASMOSIS; ASPIRATION BIOPSY ID ADRENAL-GLAND; INFECTION; CYTOLOGY AB Fine needle aspiration biopsy (FNAB) of a solitary subcutaneous Module in the upper arm of a patient being treated with corticosteroids for chronic obstructive pulmonary disease contained numerous spherical, unstained, refractile particles mixed with necrotic cellular material and rare intact histiocytes with yeastlike inclusions. The morphology of the extracytoplasmic spheroids and cytoplasmic inclusions, as demonstrated with Gomori methenamine silver stain, was characteristic of Histoplasma capsulatum var capsulatum. This organism's identification was confirmed by excisional biopsy and microbiologic testing. If the characteristic intrahistiocytic, yeastlike forms are rare or absent, recognition of this peculiar, uncommonly encountered extracellular pattern is crucial to the diagnosis of infection with H capsulatum. This pattern may become more common with increased numbers of immunosuppressed patients and increased use of FNAB. C1 BROOKE ARMY MED CTR,DEPT PATHOL,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DEPT MED,FT SAM HOUSTON,TX 78234. NR 24 TC 4 Z9 4 U1 0 U2 0 PU SCI PRINTERS & PUBL INC PI ST LOUIS PA P.O. DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 SN 0001-5547 J9 ACTA CYTOL JI Acta Cytol. PD SEP-OCT PY 1994 VL 38 IS 5 BP 777 EP 781 PG 5 WC Pathology SC Pathology GA PH872 UT WOS:A1994PH87200023 PM 8091917 ER PT J AU TOOK, KJ WEISS, DS AF TOOK, KJ WEISS, DS TI THE RELATIONSHIP BETWEEN HEAVY-METAL AND RAP MUSIC AND ADOLESCENT TURMOIL - REAL OR ARTIFACT SO ADOLESCENCE LA English DT Article AB Adolescents and their parents were surveyed to investigate the association between heavy metal and rap music and adolescent psychosocial turmoil. Subjects were asked about current and past psychosocial functioning, as well as their music preferences. Adolescents who preferred heavy metal and rap music were compared with those who preferred other types of music. Results indicated that adolescents who preferred heavy metal and rap had a higher incidence of below-average school grades, school behavior problems, sexual activity, drug and alcohol use, and arrests. However, when gender was controlled, only below-average current and elementary school grades and a history of counseling in elementary school for school problems remained significant. Implications of these findings are discussed. C1 TRIPLER ARMY MED CTR,DEPT PSYCHOL,HONOLULU,HI 96859. RP TOOK, KJ (reprint author), GEN LEONARD WOOD ARMY COMMUNITY HOSP,DEPT CHILD & ADOLESCENT PSYCHIAT,FT LEONARD WOOD,MO 65473, USA. NR 15 TC 47 Z9 47 U1 1 U2 11 PU LIBRA PUBLISHERS INC PI SAN DIEGO PA 3089C CLAIREMONT DR SUITE 383, SAN DIEGO, CA 92117 SN 0001-8449 J9 ADOLESCENCE JI Adolescence PD FAL PY 1994 VL 29 IS 115 BP 613 EP 621 PG 9 WC Psychology, Developmental SC Psychology GA PM597 UT WOS:A1994PM59700009 PM 7832025 ER PT J AU ADELMAN, L GUALTIERI, J RIEDEL, SL AF ADELMAN, L GUALTIERI, J RIEDEL, SL TI A MULTIFACETED APPROACH TO EVALUATING EXPERT-SYSTEMS SO AI EDAM-ARTIFICIAL INTELLIGENCE FOR ENGINEERING DESIGN ANALYSIS AND MANUFACTURING LA English DT Article DE EXPERT SYSTEMS; KNOWLEDGE-BASED SYSTEMS; EVALUATION; TESTING ID DECISION-SUPPORT SYSTEMS; KNOWLEDGE BASE; VERIFICATION; METHODOLOGY; USER AB A multifaceted approach to evaluating expert systems is overviewed. This approach has three facets: a technical facet, for ''looking inside the black box''; an empirical facet, for assessing the system's impact on performance; and a subjective facet,for obtaining users' judgments about the system. Such an approach is required to test the system against the different types of criteria of interest to sponsors and users and is consistent with evolving life-cycle paradigms. Moreover, such an approach leads to the application of different evaluation methods to answer different types of evaluation questions. Different evaluation methods for each facet are overviewed. C1 GEORGE MASON UNIV,DEPT OPERAT RES & ENGN,FAIRFAX,VA 22030. GEORGE MASON UNIV,DEPT PSYCHOL,FAIRFAX,VA 22030. USA,RES INST,PERI RK,FT LEAVENWORTH,KS 66027. NR 71 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 40 WEST 20TH STREET, NEW YORK, NY 10011-4211 SN 0890-0604 J9 AI EDAM JI AI EDAM-Artif. Intell. Eng. Des. Anal. Manuf. PD FAL PY 1994 VL 8 IS 4 BP 289 EP 306 PG 18 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Engineering, Multidisciplinary; Engineering, Manufacturing SC Computer Science; Engineering GA QW307 UT WOS:A1994QW30700005 ER PT J AU KERCHIEF, KR AF KERCHIEF, KR TI CAUSES OF PEDIATRIC HEMATURIA - SCHISTOSOMIASIS AND ABUSE SO AMERICAN FAMILY PHYSICIAN LA English DT Letter RP KERCHIEF, KR (reprint author), TRIPLER ARMY MED CTR,HONOLULU,HI 96859, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD SEP 1 PY 1994 VL 50 IS 3 BP 535 EP 535 PG 1 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA PF005 UT WOS:A1994PF00500002 PM 8067319 ER PT J AU SJOGREN, RW COLLETON, C SHEADONOHUE, T AF SJOGREN, RW COLLETON, C SHEADONOHUE, T TI INTESTINAL MYOELECTRIC RESPONSE IN 2 DIFFERENT MODELS OF ACUTE ENTERIC INFLAMMATION SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE INTESTINAL MOTILITY; RICIN; 2,4,6-TRINITROBENZENESULFONIC ACID; EICOSANOIDS ID CLOSTRIDIUM-DIFFICILE TOXINS; COLONIC MUSCULARIS MUCOSAE; EXPERIMENTAL COLITIS; ULCERATIVE-COLITIS; GASTROINTESTINAL TISSUES; LEUKOTRIENE SYNTHESIS; ARACHIDONIC-ACID; SMOOTH-MUSCLE; RATS; PROSTAGLANDIN-E2 AB The inflammatory responses to intraluminal administration of the cytotoxic lectin ricin or the hapten 2,4,6-trinitrobenzenesulfonic acid in 25% ethanol were compared. Myoelectric activity was recorded from in vivo ileal loops in rabbits after administration of either agent. At the end of a 6-h study the loops were removed and prepared for histological evaluation and for ex vivo generation of leukotriene (LT) C-4 and prostaglandin (PG) E(2). Both agents induced significant increases in mucosal damage, polymorphonuclear leukocyte infiltration, and edema. These changes tended to be patchy in the hapten model and confluent in the ricin model. Spike burst activity and mucosal LTC(4) and PGE(2) generation were also enhanced significantly. Intraluminal administration of the specific LTD(4) antagonist Wy-48252 1 h before either inflammagen, significantly inhibited the myoelectric response without affecting tissue morphology or eicosanoid synthesis. These data demonstrate that there is a stereotypic spike burst response to acute inflammation, which is mediated in part by LTD(4). C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV PATHOL,WASHINGTON,DC 20307. NR 37 TC 26 Z9 26 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD SEP PY 1994 VL 267 IS 3 BP G329 EP G337 PN 1 PG 9 WC Physiology SC Physiology GA PH382 UT WOS:A1994PH38200042 PM 7943229 ER PT J AU GAGLIARDI, JA CHUNG, EM CHANDNANI, VP KESLING, KL CHRISTENSEN, KP NULL, RN RADVANY, MG HANSEN, MF AF GAGLIARDI, JA CHUNG, EM CHANDNANI, VP KESLING, KL CHRISTENSEN, KP NULL, RN RADVANY, MG HANSEN, MF TI DETECTION AND STAGING OF CHONDROMALACIA PATELLAE - RELATIVE EFFICACIES OF CONVENTIONAL NIR IMAGING, MR ARTHROGRAPHY, AND CT ARTHROGRAPHY SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article ID ARTICULAR-CARTILAGE; HYALINE CARTILAGE; KNEE; INVITRO; JOINT AB OBJECTIVE. Chondromalacia patellae is a condition characterized by softening, fraying, and ulceration of patellar articular cartilage. We compare the sensitivity, specificity, and accuracy of conventional MR imaging, MR arthrography, and CT arthrography in detecting and staging this abnormality. SUBJECTS AND METHODS. Twenty-seven patients with pain in the anterior part of the knee were prospectively examined with MR imaging, including T1-weighted (650/16), proton density-weighted (2000/20), TS-weighted (2000/80), and spoiled two-dimensional gradient-recalled acquisition in the steady state (SPGR)/35 degrees (51/10) with fat saturation pulse sequences. All were also examined with T1-weighted MR imaging after intraarticular injection of dilute gadopentetate dimeglumine and with double-contrast CT arthrography. Each imaging technique was evaluated independently by two observers, who reached a consensus interpretation. The signal characteristics of cartilage on MR images and contour abnormalities noted with all imaging techniques were evaluated and graded according to a modification of the classification of Shahriaree. Twenty-six of the 54 facets examined had chondromalacia shown by arthroscopy, which was used as the standard of reference. The sensitivity, specificity, and accuracy of each imaging technique in the diagnosis of each stage of chondromalacia patellae were determined and compared by using the McNemar two-tailed analysis. RESULTS. Arthroscopy showed that 28 facets were normal. Grade 1 chondromalacia patellae was diagnosed only with MR and CT arthrography in two (29%) of seven facets. Intermediate (grade 2 or 3) chondromalacia patellae was detected in two (13%) of 15 facets with TI-weighted and SPGR MR imaging, in three (20%) of 15 facets with proton density-weighted MR imaging, in seven (47%) of 15 facets with TS-weighted MR imaging, in 11 (73%) of 15 facets with CT arthrography, and in 12 (80%) of 15 facets with MR arthrography. Grade 4 was detected in three (75%) of four facets with T1-, proton density-, and T2-weighted MR imaging, two (50%) of four facets with SPGR MR imaging, and four (100%) of four facets with MR and CT arthrography. Thus, all imaging techniques were insensitive to grade 1 lesions and highly sensitive to grade 4 lesions, so that no significant difference among the techniques could be shown. CONCLUSION. All imaging techniques studied had high specificity and accuracy in the detection and grading of chondromalacia patella; however, both MR arthrography and CT arthrography were more sensitive than T1-weighted, proton density-weighted, and SPGR with fat saturation MR imaging for showing intermediate grades of chondromalacia patellae. Although the arthrographic techniques were not significantly better than T2-weighted imaging, the number of false-positive diagnoses was greatest with T2-weighted MR imaging. C1 TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT ORTHOPED SURG,HONOLULU,HI 96859. NR 24 TC 128 Z9 131 U1 0 U2 3 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD SEP PY 1994 VL 163 IS 3 BP 629 EP 636 PG 8 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA PF504 UT WOS:A1994PF50400028 PM 8079858 ER PT J AU CHANDNANI, VP AF CHANDNANI, VP TI APPROVAL FROM THE FOOD-AND-DRUG-ADMINISTRATION FOR UNAPPROVED USE OF AN APPROVED DRUG OR DEVICE - REPLY SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Letter RP CHANDNANI, VP (reprint author), TRIPLER ARMY MED CTR,HONOLULU,HI 96859, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD SEP PY 1994 VL 163 IS 3 BP 748 EP 749 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA PF504 UT WOS:A1994PF50400076 ER PT J AU ARCIERO, RA WHEELER, JH RYAN, JB MCBRIDE, JT AF ARCIERO, RA WHEELER, JH RYAN, JB MCBRIDE, JT TI ARTHROSCOPIC BANKART REPAIR VERSUS NONOPERATIVE TREATMENT FOR ACUTE, INITIAL ANTERIOR SHOULDER DISLOCATIONS SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article AB A prospective study evaluating nonoperative treatment versus arthroscopic Bankart suture repair for acute, initial dislocation of the shoulder was undertaken in young athletes. All patients met the following criteria: 1) sustained an acute first-time traumatic anterior dislocation, 2) no history of impingement or occult subluxation, 3) the dislocation required a manual reduction, and 4) no concomitant neurologic injury. Thirty-six athletes (average age, 20 years) met the criteria for inclusion. Group I patients were immobilized for 1 month followed by rehabilitation; they were allowed full activity at 4 months. Group II patients underwent arthroscopic Bankart repair followed by the same protocol as Group I. Group I consisted of 15 athletes. Twelve patients (80%) developed recurrent instability; 7 of the 12 have required open Bankart repair for recurrent instability. Group II consisted of 21 patients; 18 patients (86%) had no recurrent instability at last followup (average, 32 months; range, 15 to 45) (P = 0.001). One patient in Group II has required a subsequent open Bankart repair to treat symptomatic recurrence (P = 0.005). In this study, arthroscopic Bankart repair significantly reduced the recurrence rate in young athletes who sustained an acute, initial anterior dislocation of the shoulder. RP ARCIERO, RA (reprint author), KELLER ARMY HOSP,ORTHOPAED SERV,W POINT,NY 10996, USA. NR 0 TC 197 Z9 201 U1 1 U2 11 PU AMER ORTHOPAEDIC SOC SPORT MED PI WALTHAM PA 230 CALVARY STREET, WALTHAM, MA 02154 SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD SEP-OCT PY 1994 VL 22 IS 5 BP 589 EP 594 DI 10.1177/036354659402200504 PG 6 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA PG134 UT WOS:A1994PG13400004 PM 7810780 ER PT J AU BREWER, TG GRATE, SJ PEGGINS, JO WEINA, PJ PETRAS, JM LEVINE, BS HEIFFER, MH SCHUSTER, BG AF BREWER, TG GRATE, SJ PEGGINS, JO WEINA, PJ PETRAS, JM LEVINE, BS HEIFFER, MH SCHUSTER, BG TI FATAL NEUROTOXICITY OF ARTEETHER AND ARTEMETHER SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article AB Artemisinin (qinghaosu) and several derivatives have been developed and are in use as antimalarial drugs but scant information is available regarding animal or human toxicity. Following a eight-day, multiple-dose, pharmacokinetic study of arteether (AE) (10 mg/kg/day [n = 6] and 20 mg/kg/day [n = 6]) in dogs, all high-dose animals displayed a progressive syndrome of clinical neurologic defects with progressive cardiorespiratory collapse and death in five of six animals. Neurologic findings included gait disturbances, loss of spinal and pain response reflexes, and prominent loss of brain stem and eye reflexes. Animals had prolongation of QT interval corrected for rate (QTc) on electrocardiograms (ECGs) with bizarre ST-T segment changes. Prominent neuropathic lesions were noted to be primarily limited to the pens and medulla. Similar lesions with dose-related severity were noted in eight other dogs studied in a second study with intramuscular (IM) administration of AE in sesame oil during a 28-day, dose-ranging study using 5, 10, 15, and 20 mg/kg/day. Injury, graded by a pathologist blinded to the dose group, showed a dose-related, region-specific injury in all animals that was most pronounced in the pens. Further studies in Sprague-Dawley rats using LM administration of AE and artemether (AM) at st dose of 12.5-50 mg/kg/day for 28 days confirmed the onset of a clinical neurologic syndrome with dose-related changes in body weight, activity, and seizure-Like activity, stereotypic movement disorders, and ECG changes. Neuropathologic examination of rat brain sections at five levels from the rostral cerebrum to the caudal medulla showed a dose-related, region-specific pattern of injury characterized by a loss of Nissl substance and hyalinized neuron cell bodies; these changes are congruent with those noted in dogs. No significant differences were noted in the extent, type, or distribution of lesions in brains of rats treated with equivalent doses of AE or AM. We conclude that 1) a dose-related neurologic syndrome associated with movement disturbances, spasticity, and depressed sensorium in dogs and rats occurred after daily LM injections of two artemisinin antimalarial drugs, AE and AM; 2) a prolonged QTc interval was noted as a preterminal clinical finding in dogs and rats treated with high-dose AE; 3) central nervous system neuropathic changes were noted to occur in a dose-related and anatomic-specific manner in both dogs and rats treated with daily LM injections of AE or AM; and 4) the mechanism and etiology for this lesion are not known from this study, but the findings suggest a long lived toxic drug metabolite. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV PATHOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307. UNIV ILLINOIS,DEPT PHARMACOL,TOXICOL RES LAB,CHICAGO,IL 60612. RP BREWER, TG (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 11 TC 195 Z9 198 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD SEP PY 1994 VL 51 IS 3 BP 251 EP 259 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA PJ690 UT WOS:A1994PJ69000001 PM 7943542 ER PT J AU BUREK, KA ROSSI, CA LEDUC, JW YUILL, TM AF BUREK, KA ROSSI, CA LEDUC, JW YUILL, TM TI SEROLOGIC AND VIROLOGICAL EVIDENCE OF A PROSPECT HILL-LIKE HANTAVIRUS IN WISCONSIN AND MINNESOTA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID KOREAN HEMORRHAGIC-FEVER; POLYMERASE CHAIN-REACTION; RENAL SYNDROME; UNITED-STATES; ETIOLOGIC AGENT; NEPHROPATHIA EPIDEMICA; HUMAN INFECTION; DOBRAVA VIRUS; HANTAAN VIRUS; URBAN RATS AB The purposes of this study were to determine if hantaviruses were present in the Great Lakes port areas of Wisconsin and Minnesota and if so, to identify which virus and which rodent host species were involved. Rodents were trapped in Duluth, Minnesota, Superior, Green Bay, and Milwaukee, Wisconsin, all ports of call for international maritime shipping. A total of 675 wild rodents were captured and tested, including 310 meadow voles (Microtus pennsylvanicus), 173 Norway rats (Rattus norvegicus), 179 Peromyscus spp., (including white footed mice [P. leucopus] and deer mice [P. maniculatus gracilis and P. maniculatus bairdii]), and 13 house mice (Mus musculus). Twenty percent of the rats, 17% of the meadow voles, 8% of the house mice, and 3% of the Peromyscus spp. had antibody to a hantavirus by immunofluorescent antibody assay (IFA). By the plaque-reduction neutralization test (PRNT), nine of 36 meadow voles, one of 4 P. leucopus, and one of 34 rats had hantavirus antibody, with the highest titers to Prospect Hill (PH) virus. All of the PRNT-seropositive individuals were from the twin cities of Superior and Duluth. Hantavirus antigen was detected in lung tissue by IFA in M. pennsylvanicus and Peromyscus spp., but not in rats. Two hantaviruses, designated SD-1 and SD-2, were isolated from M. pennsylvanicus captured in Duluth and found to be very similar to prototype PH virus by cross-IFA and cross-PRNT Virus isolation attempts were unsuccessful from tissues of the Peromyscus spp. and the rats. C1 UNIV WISCONSIN,INST ENVIRONM STUDIES,DEPT VET SCI,MADISON,WI 53705. UNIV WISCONSIN,DEPT PATHOBIOL SCI,MADISON,WI 53706. USA,MED RES INST INFECT DIS,DIV APPL RES,FT DETRICK,MD 21702. FU NIAID NIH HHS [AI-00771] NR 40 TC 9 Z9 9 U1 1 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD SEP PY 1994 VL 51 IS 3 BP 286 EP 294 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA PJ690 UT WOS:A1994PJ69000005 PM 7943546 ER PT J AU KREUTZER, RD YEMMA, JJ GROGL, M TESH, RB MARTIN, TI AF KREUTZER, RD YEMMA, JJ GROGL, M TESH, RB MARTIN, TI TI EVIDENCE OF SEXUAL REPRODUCTION IN THE PROTOZOAN PARASITE LEISHMANIA (KINETOPLASTIDA, TRYPANOSOMATIDAE) SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MYXOMYCETE DIDYMIUM-IRIDIS; CUTANEOUS LEISHMANIASIS; CULTIVATION; MEMBRANE; MEDIA; DNA AB Parasitic protozoa of the genus Leishmania (Kinetoplastida: Trypanosomatidae) are generally thought to multiply by binary fission; however, data from quantitative microspectrophotometry indicate that nuclear fusion or sexual reproduction takes place in the intracellular amastigote form. Among several different Leishmania species, the mean +/- SD nuclear DNA content of all promastigotes (extracellular form) and of some amastigotes (intracellular form) in macrophages was 0.098 +/- 0.032 relative units; in contrast, other amastigotes within the same macrophage had a mean +/- SD nuclear DNA content of 0.219 +/- 0.050. The latter population of amastigotes are apparently produced when the nuclei of a pair of 0.098 amastigotes fuse. These 0.219 amastigotes later go through what is probably the typical meiotic cycle to reform the 0.098 condition we observed among promastigotes. The demonstration of sexual reproduction in Leishmania has important implications for the future direction of research on this medically important parasite. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. YALE UNIV,SCH MED,DEPT EPIDEMIOL & PUBL HLTH,NEW HAVEN,CT 06520. RP KREUTZER, RD (reprint author), YOUNGSTOWN STATE UNIV,DEPT BIOL,YOUNGSTOWN,OH 44555, USA. NR 25 TC 13 Z9 13 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD SEP PY 1994 VL 51 IS 3 BP 301 EP 307 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA PJ690 UT WOS:A1994PJ69000007 PM 7943548 ER PT J AU BENEDIKT, AC BENEDIKT, RA HANTLER, CB ROBERTSON, MC JONES, DJ AF BENEDIKT, AC BENEDIKT, RA HANTLER, CB ROBERTSON, MC JONES, DJ TI INCREASING THE CROSS-SECTIONAL AREA OF THE INTERNAL JUGULAR-VEIN - TRENDELENBURG VS VALSALVA SO ANESTHESIOLOGY LA English DT Meeting Abstract C1 UTHSC,DEPT ANESTHESIOL,SAN ANTONIO,TX 78284. BROOKE ARMY MED CTR,DEPT RADIOL,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD SEP PY 1994 VL 81 IS 3A SU S BP A1266 EP A1266 PG 1 WC Anesthesiology SC Anesthesiology GA PJ091 UT WOS:A1994PJ09101265 ER PT J AU BETTENCOURT, J GORDON, J FROELICH, E ANTOINE, J AF BETTENCOURT, J GORDON, J FROELICH, E ANTOINE, J TI A COMPARISON BETWEEN MANNITOL ALONE AND MANNITOL PLUS FUROSEMIDE ON INCREASING SERUM OSMOLALITY DURING CRANIOTOMY SO ANESTHESIOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 2 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD SEP PY 1994 VL 81 IS 3A SU S BP A239 EP A239 PG 1 WC Anesthesiology SC Anesthesiology GA PJ091 UT WOS:A1994PJ09100239 ER PT J AU GREILICH, PE CARR, ME AF GREILICH, PE CARR, ME TI REDUCTIONS IN PLATELET FORCE DEVELOPMENT BY CARDIOPULMONARY BYPASS ARE ASSOCIATED WITH HEMORRHAGE SO ANESTHESIOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT ANESTHESIOL,WASHINGTON,DC 20307. HH MCGUIRE VET ADM MED CTR,SPECIAL STUDIES COAGULAT LAB,RICHMOND,VA 23249. NR 4 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD SEP PY 1994 VL 81 IS 3A SU S BP A551 EP A551 PG 1 WC Anesthesiology SC Anesthesiology GA PJ091 UT WOS:A1994PJ09100550 ER PT J AU KARAN, SM LOJESKI, EW MILLS, L KLINE, MD BEODEKER, BH AF KARAN, SM LOJESKI, EW MILLS, L KLINE, MD BEODEKER, BH TI FEMORAL VS CENTRAL VENOUS-BLOOD GAS DATA DURING MALIGNANT HYPERTHERMIA IN SUSCEPTIBLE SWINE SO ANESTHESIOLOGY LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,DEPT ANESTH,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 3 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD SEP PY 1994 VL 81 IS 3A SU S BP A430 EP A430 PG 1 WC Anesthesiology SC Anesthesiology GA PJ091 UT WOS:A1994PJ09100429 ER PT J AU KUZMA, PJ KLINE, MD BOEDEKER, BH MATTIX, ME YOUNG, PC COBB, JT HAYNES, DH AF KUZMA, PJ KLINE, MD BOEDEKER, BH MATTIX, ME YOUNG, PC COBB, JT HAYNES, DH TI TISSUE TOXICITY OF LECITHIN-COATED BUPIVACAINE MICROCRYSTALS AFTER INTRADERMAL INFILTRATION SO ANESTHESIOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 3 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD SEP PY 1994 VL 81 IS 3A SU S BP A1034 EP A1034 PG 1 WC Anesthesiology SC Anesthesiology GA PJ091 UT WOS:A1994PJ09101033 ER PT J AU KUZMA, PJ KLINE, MD BOEDEKER, BH HAYNES, DH AF KUZMA, PJ KLINE, MD BOEDEKER, BH HAYNES, DH TI MICROCRYSTALLINE BUPIVACAINE COATED WITH LECITHIN PRODUCES ULTRA LONG-DURATION LOCAL-ANESTHESIA IN THE RAT TAIL SO ANESTHESIOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 4 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD SEP PY 1994 VL 81 IS 3A SU S BP A1033 EP A1033 PG 1 WC Anesthesiology SC Anesthesiology GA PJ091 UT WOS:A1994PJ09101032 ER PT J AU ONEILL, BL FOLEY, EP CHANG, A AF ONEILL, BL FOLEY, EP CHANG, A TI EFFECTS OF HUMIDIFICATION OF INSPIRED GASES WITH THE LARYNGEAL MASK AIRWAY SO ANESTHESIOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT ANESTHESIOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 0 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD SEP PY 1994 VL 81 IS 3A SU S BP A52 EP A52 PG 1 WC Anesthesiology SC Anesthesiology GA PJ091 UT WOS:A1994PJ09100052 ER PT J AU CARREGAL, VA DAVIS, WS CARPENTER, GB ENGLER, RJ AF CARREGAL, VA DAVIS, WS CARPENTER, GB ENGLER, RJ TI RECURRENT SINOPULMONARY DISEASE IN A YOUNG-ADULT SO ANNALS OF ALLERGY LA English DT Editorial Material ID PRIMARY CILIARY DYSKINESIA; CYSTIC-FIBROSIS; IMMOTILE CILIA; BEAT FREQUENCY; BRONCHIECTASIS; IMMUNODEFICIENCY; ULTRASTRUCTURE; ORIENTATION; SPUTUM; GENE C1 WALTER REED ARMY MED CTR,ALLERGY IMMUNOL FELLOWSHIP PROGRAM,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,CLIN LAB IMMUNOL FELLOWSHIP PROGRAM,WASHINGTON,DC 20307. RP CARREGAL, VA (reprint author), WALTER REED ARMY MED CTR,CLIN LAB,ALLERGY IMMUNOL SERV,WASHINGTON,DC 20307, USA. NR 24 TC 1 Z9 1 U1 0 U2 0 PU AMER COLL ALLERGY ASTHMA IMMUNOLOGY PI ARLINGTON HTS PA 85 WEST ALGONQUIN RD SUITE 550, ARLINGTON HTS, IL 60005 SN 0003-4738 J9 ANN ALLERGY JI Ann. Allergy PD SEP PY 1994 VL 73 IS 3 BP 208 EP 213 PG 6 WC Allergy SC Allergy GA PG917 UT WOS:A1994PG91700003 ER PT J AU CIOFFI, WG GORE, DC RUE, LW CARROUGHER, G GULER, HP MCMANUS, WF PRUITT, BA AF CIOFFI, WG GORE, DC RUE, LW CARROUGHER, G GULER, HP MCMANUS, WF PRUITT, BA TI INSULIN-LIKE GROWTH-FACTOR-I LOWERS PROTEIN OXIDATION IN PATIENTS WITH THERMAL-INJURY SO ANNALS OF SURGERY LA English DT Article; Proceedings Paper CT 114th Annual Scientific-Session of the American-Surgical-Association CY APR 07-09, 1994 CL SAN ANTONIO, TX SP AMER SURG ASSOC ID RECEIVING PARENTERAL-NUTRITION; OPTIMAL GLUCOSE-INFUSION; AMINO-ACID-METABOLISM; FACTOR-I; BURNED PATIENTS; WHOLE-BODY; IGF-I; HORMONE; CATABOLISM; KINETICS AB Objective The effect of insulin-like growth factor-1 (IGF-1) on energy expenditure and protein and glucose metabolism in a group of patients with thermal injury was determined. Summary Background Data Accelerated protein catabolism is a constant feature of the hypermetabolic response to thermal injury. insulin-like growth factor-1 has been reported to minimize protein catabolism and normalize energy expenditure in animal models of thermal injury. Methods To determine the efficacy of IGF-1 in human burn patients, resting energy expenditure (metabolic cart), whole body protein kinetics ((N)15 Lysine), and glucose disposal (glucose tolerance test) were assessed in eight burn patients before and after a 3-day infusion of IGF-1 (20 mu g/kg/hr). All patients were fluid-resuscitated uneventfully and were without obvious infection at the time of study. Enteral nutrition was administered at a constant rate before and during the IGF-1 infusion. Results Resting energy expenditure was not altered by IGF-1 (40.3 +/- 2.2 vs. 39.1 +/- 2.3 kcal/kg/day). However, glucose uptake was promoted, and protein oxidation decreased significantly (0.118 +/- 0.029 vs. 0.087 +/- 0.021 g/kg/d, p < 0.05) by IGF-1. In addition, insulin secretion, in response to a glucose challenge, was blunted. Conclusions Insulin-like growth factor-1 therapy has a beneficial effect in preserving lean body mass during severe stress conditions by minimizing the flux of amino acids toward oxidation. C1 VIRGINIA COMMONWEALTH UNIV MED COLL VIRGINIA,DEPT SURG,RICHMOND,VA. UNIV ALABAMA,DEPT SURG,BIRMINGHAM,AL 35294. CIBA GEIGY CORP,SUMMIT,NJ. RP CIOFFI, WG (reprint author), USA,INST SURG RES,LIBRARY BRANCH,FT SAM HOUSTON,TX 78234, USA. NR 45 TC 85 Z9 87 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-4932 J9 ANN SURG JI Ann. Surg. PD SEP PY 1994 VL 220 IS 3 BP 310 EP 319 DI 10.1097/00000658-199409000-00007 PG 10 WC Surgery SC Surgery GA PH670 UT WOS:A1994PH67000007 PM 8092898 ER PT J AU ADOMIAN, G RACH, R MEYERS, RE AF ADOMIAN, G RACH, R MEYERS, RE TI SOLUTION OF GENERIC NONLINEAR OSCILLATORS SO APPLIED MATHEMATICS AND COMPUTATION LA English DT Article AB The paper outlines a procedure which solves arbitrary oscillator equations with any experimentally determined nonlinearities. A Van der Pol equation is used to explain the procedure and variations for other possible oscillators. C1 USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88001. RP ADOMIAN, G (reprint author), GEN ANALYT CORP,155 CLYDE RD,ATHENS,GA 30605, USA. NR 3 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0096-3003 J9 APPL MATH COMPUT JI Appl. Math. Comput. PD SEP PY 1994 VL 64 IS 2-3 BP 167 EP 170 DI 10.1016/0096-3003(94)90061-2 PG 4 WC Mathematics, Applied SC Mathematics GA PM452 UT WOS:A1994PM45200008 ER PT J AU ANDERSON, LL SAMLASKA, CP CARDONE, JS HOLTZMULLER, KC AF ANDERSON, LL SAMLASKA, CP CARDONE, JS HOLTZMULLER, KC TI TREATMENT OF PYODERMA-GANGRENOSUM WITH 4-PERCENT CROMOLYN SO ARCHIVES OF DERMATOLOGY LA English DT Note ID DISODIUM-CROMOGLYCATE; ACTIVATION; NEUTROPHIL; SODIUM C1 TRIPLER ARMY MED CTR,HONOLULU,HI. RP ANDERSON, LL (reprint author), DARNALL ARMY HOSP,FT HOOD,TX 76544, USA. NR 23 TC 8 Z9 8 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD SEP PY 1994 VL 130 IS 9 BP 1117 EP 1120 DI 10.1001/archderm.130.9.1117 PG 4 WC Dermatology SC Dermatology GA PG192 UT WOS:A1994PG19200002 PM 8085865 ER PT J AU ARMSTRONG, JH BARCIA, PJ AF ARMSTRONG, JH BARCIA, PJ TI PILONIDAL-SINUS DISEASE - THE CONSERVATIVE APPROACH SO ARCHIVES OF SURGERY LA English DT Article; Proceedings Paper CT 65th Annual Meeting of the Pacific-Coast-Surgical-Association CY FEB 21-23, 1994 CL SACRAMENTO, CA SP PACIFIC COAST SURG ASSOC AB Objective: To examine the role of conservative, nonexcisional methods in the treatment of pilonidal sinus disease. Design: Pilot nonrandomized cohort study and follow-up retrospective study. Setting and Patients: In the pilot study, all patients treated for pilonidal sinus disease consecutively over 3 years at an Army community hospital, and in the follow-up study within a closed federal population, all patients admitted with a diagnosis of pilonidal sinus disease over 17 years to an Army medical center. Interventions: Conservative, nonexcisional therapy (meticulous hair control by natal cleft shaving, improved perineal hygiene, and limited lateral incision and drainage for abscess) with initial comparison to excisional procedures. Main Outcome Measures: Occupied-bed days for conservative vs excisional therapy during a 3-year pilot study and the number of admissions and procedures performed for pilonidal sinus disease at an institution dedicated to conservative treatment alone. Results: Complete healing over 83 occupied-bed days was demonstrated in 101 consecutive cases managed during 1 year with the conservative method, whereas slower healing over 4760 occupied-bed days was observed in 229 patients undergoing 240 operative procedures during the preceding 2 years. With application of conservative treatment over 17 years, only 23 excisional operatoions were performed. Conclusions: Conservative therapy effectively controls pilonidal sinus disease in the nonoperative outpatient setting while promoting near-normal work status and is preferred over excisional operations. C1 TRIPLER ARMY MED CTR,DEPT SURG,GEN SURG SERV,HONOLULU,HI 96859. NR 11 TC 85 Z9 86 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0004-0010 J9 ARCH SURG-CHICAGO JI Arch. Surg. PD SEP PY 1994 VL 129 IS 9 BP 914 EP 917 PG 4 WC Surgery SC Surgery GA PF681 UT WOS:A1994PF68100005 PM 8080372 ER PT J AU LAKHANI, H AF LAKHANI, H TI THE SOCIOECONOMIC BENEFITS TO MILITARY FAMILIES OF HOME-BASING OF ARMED-FORCES SO ARMED FORCES & SOCIETY LA English DT Article ID UNITED-STATES-ARMY; MULTIDISCIPLINARY ANALYSIS AB The home-basing or relocation of military units from Outside Continental United States (OCONUS) to Continental United States (CONUS) and the proposed increase in time from three to six years at CONUS locations is hypothesized to generate considerable socioeconomic benefits. Analysis of the Survey of Army Families, 1987, and Army Family Survey Research data reveal that home-basing is likely to improve quality of spouse employment and the quality of family life of soldiers. An increase in time at a location by three years is likely to increase spouse earnings by 14 percent. An increase in spouse employment due to home-basing is also associated with an increase in spouse's satisfaction with Army life which, in turn, tends to increase spouse's desire for soldier-husband's retention in the Army. The home-basing is also likely to reduce child care costs to the Army and to the soldiers because of lower child care costs in CONUS relative to OCONUS. Three limitations of home-basing and Army policy measures for mitigating them are also discussed. RP LAKHANI, H (reprint author), USA,BEHAV & SOCIAL SCI RES INST,DIV MANPOWER & PERSONNEL RES,ALEXANDRIA,VA, USA. NR 20 TC 6 Z9 6 U1 1 U2 1 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD FAL PY 1994 VL 21 IS 1 BP 113 EP 128 DI 10.1177/0095327X9402100107 PG 16 WC Political Science; Sociology SC Government & Law; Sociology GA PU001 UT WOS:A1994PU00100006 ER PT J AU CONDONRALL, ME AF CONDONRALL, ME TI THE ARMY WAR AGAINST MALARIA - COLLABORATION IN DRUG RESEARCH DURING WORLD-WAR-2 SO ARMED FORCES & SOCIETY LA English DT Article AB During the second half of World War II, U.S. and Allied military and civilian scientists cooperated in helping the armed forces combat malaria. They worked through the Offices of the Surgeon General of the U.S. Army and the U.S. Navy, the National Research Council, the Board for the Coordination of Malarial Studies, the Office of Scientific Research and Development, the Austrialian Military Mission, and the British Medical Research Council, all in Washington, D.C. The Board for the Coordination of Malarial Studies, which the National Research Council established in November 1943 to guide research expansion and coordinate joint efforts, became the focal point for collaboration on research. These alliances produced hundreds of malaria studies and thousands of new compounds some of which tested superior to traditional antimalarial drugs. This cooperative effort improved chemotherapy for the prevention and treatment of malaria after years of neglect in the development of antimalarial drugs. This article focuses on the establishment of the Board for the Coordination of Malarial Studies, the development of new antimalarial drugs, and collaboration with allies on drugs research. The latter produced special U.S.-Australian and U.S.-Britain relationships. C1 USA,CTR MIL,WASHINGTON,DC 20310. NR 38 TC 3 Z9 3 U1 0 U2 0 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD FAL PY 1994 VL 21 IS 1 BP 129 EP 143 DI 10.1177/0095327X9402100108 PG 15 WC Political Science; Sociology SC Government & Law; Sociology GA PU001 UT WOS:A1994PU00100007 ER PT J AU MANOS, AM AF MANOS, AM TI PEACEKEEPERS AND THEIR WIVES - AMERICAN PARTICIPATION IN THE MULTINATIONAL FORCE AND OBSERVERS - SEGAL,DR, SEGAL,MW SO ARMED FORCES & SOCIETY LA English DT Book Review RP MANOS, AM (reprint author), USA,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD FAL PY 1994 VL 21 IS 1 BP 151 EP 153 DI 10.1177/0095327X9402100111 PG 3 WC Political Science; Sociology SC Government & Law; Sociology GA PU001 UT WOS:A1994PU00100010 ER PT J AU MOREY, AF PLYMYER, M ROZANSKI, TA DESHON, GE MYERS, JB DRESNER, ML AF MOREY, AF PLYMYER, M ROZANSKI, TA DESHON, GE MYERS, JB DRESNER, ML TI BIOPTY GUN TESTIS NEEDLE-BIOPSY - A PRELIMINARY CLINICAL-EXPERIENCE SO BRITISH JOURNAL OF UROLOGY LA English DT Article DE TESTIS; BIOPSY; TRANSCUTANEOUS ID FLOW-CYTOMETRY AB Objective To assess the reliability, safety and patient satisfaction of transcutaneous Biopty (Bard Urological, Covington, GA, USA) gun testis biopsies. Patients and methods Nineteen young men who were referred for evaluation of azoospermia were included in the study. The procedure was performed in an outpatient setting, under local anaesthesia and without sedation. Two passes of the Biopty gun spring-loaded needle were performed unilaterally in each patient. Results An average of 38.9 seminiferous tubules were evaluable per patient. The procedure was extremely well-tolerated by all patients and most felt that the procedure was no more distressing than simple phlebotomy. Conclusion Transcutaneous testis needle biopsy performed with the Biopty gun is safe, rapid and cost-effective. This technique may represent a viable alternative to the open method of testis biopsy. C1 TRIPLER ARMY MED CTR,DEPT SURG,UROL SERV,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT PATHOL,HONOLULU,HI. NR 14 TC 19 Z9 19 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0007-1331 J9 BRIT J UROL JI Br. J. Urol. PD SEP PY 1994 VL 74 IS 3 BP 366 EP 369 DI 10.1111/j.1464-410X.1994.tb16628.x PG 4 WC Urology & Nephrology SC Urology & Nephrology GA PE685 UT WOS:A1994PE68500021 PM 7953269 ER PT J AU IZRAELI, S ADAMSON, PC BLANEY, SM BALIS, FM AF IZRAELI, S ADAMSON, PC BLANEY, SM BALIS, FM TI ACUTE-PANCREATITIS AFTER IFOSFAMIDE THERAPY SO CANCER LA English DT Article DE PANCREATITIS; IFOSFAMIDE; CHEMOTHERAPY; OSTEOSARCOMA; CASE REPORT AB Acute pancreatitis is an uncommon but serious complication of cancer chemotherapy. A 16-year-old girl with metastatic osteosarcoma experienced recurrent bouts of symptomatic pancreatitis 24 hours after treatment with ifosfamide administered as a single agent. To the authors' knowledge, this is the first report of an association between ifosfamide and pancreatitis. Because serum amylase levels are not monitored routinely during treatment with most chemotherapeutic agents, subclinical cases of pancreatitis with ifosfamide and other agents may go undetected. C1 WALTER REED ARMY MED CTR,DEPT PEDIAT HEMATOL ONCOL,WASHINGTON,DC 20307. RP IZRAELI, S (reprint author), NCI,PEDIAT BRANCH,BLDG 10,ROOM 13N240,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA. NR 6 TC 12 Z9 12 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD SEP 1 PY 1994 VL 74 IS 5 BP 1627 EP 1628 DI 10.1002/1097-0142(19940901)74:5<1627::AID-CNCR2820740522>3.0.CO;2-U PG 2 WC Oncology SC Oncology GA PD349 UT WOS:A1994PD34900021 PM 8062195 ER PT J AU FLAHERTY, S GRISHKIN, BA AF FLAHERTY, S GRISHKIN, BA TI AIRWAY-OBSTRUCTION BY ANTERIOR MEDIASTINAL MASS - SUCCESSFUL MANAGEMENT BY PERCUTANEOUS ASPIRATION SO CHEST LA English DT Note ID ANESTHETIC MANAGEMENT AB An anterior mediastinal mass producing extrinsic airway obstruction was successfully managed by percutaneous needle aspiration, decompressing the mass and relieving the airway obstruction. This allowed safe induction of general endotracheal anesthesia and excision of the mass by a sternotomy approach. C1 EISENHOWER ARMY MED CTR,THORAC SURG SERV,FT GORDON,GA. NR 6 TC 3 Z9 3 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD SEP PY 1994 VL 106 IS 3 BP 947 EP 948 DI 10.1378/chest.106.3.947 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA PG605 UT WOS:A1994PG60500061 PM 8082385 ER PT J AU FISHER, CJ OPAL, SM LOWRY, SF SADOFF, JC LABRECQUE, JF DONOVAN, HC LOOKABAUGH, JL LEMKE, J PRIBBLE, JP STROMATT, SC VIGERS, GP RUSSELL, DA THOMPSON, RC AF FISHER, CJ OPAL, SM LOWRY, SF SADOFF, JC LABRECQUE, JF DONOVAN, HC LOOKABAUGH, JL LEMKE, J PRIBBLE, JP STROMATT, SC VIGERS, GP RUSSELL, DA THOMPSON, RC TI ROLE OF INTERLEUKIN-1 AND THE THERAPEUTIC POTENTIAL OF INTERLEUKIN-1 RECEPTOR ANTAGONIST IN SEPSIS SO CIRCULATORY SHOCK LA English DT Article DE ARDS; DIC; RENAL DYSFUNCTION; SHOCK; PERFUSION DEFICIT; ACIDOSIS; CLINICAL TRIAL ID TUMOR-NECROSIS-FACTOR; GRAM-NEGATIVE SEPSIS; IMPROVES SURVIVAL; SEPTIC SHOCK; ENDOTOXIN; RABBITS; ANTIBODY; TRIAL; IL-1; RATS AB Clinical trials of anticytokines in sepsis have not been as straightforward as had been anticipated from results in animal models of sepsis and the role of cytokines in sepsis is now in question, Retrospective analysis of the results of a phase III trial of interleukin-1 (IL-1) receptor antagonist suggests that sepsis-induced adult respiratory distress syndrome (ARDS), disseminated intravascular coagulation (DIC), renal dysfunction, and shock are valuable markers of patients in whom IL-1 is a pathogenic mediator and in whom IL-1 ra can reduce mortality. A re-examination of the effects of IL-1ra in animal models of sepsis supports the validity of this analysis. A new phase III clinical trial will confirm or disprove the hypothesis that IL-1 is a mediator of pathology, and IL-1ra is a valuable therapy for sepsis complicated by ARDS, DIG, renal dysfunction, or shock. (C) 1994 Wiley-Liss, Inc. C1 BROWN UNIV,SCH MED,DEPT MED,PAWTUCKET,RI. NEW YORK HOSP,CORNELL MED CTR,DEPT SURG,NEW YORK,NY 10021. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. SYNERGEN INC,BOULDER,CO 80301. UNIV IOWA,DEPT PREVENT MED & ENVIRONM HLTH,IOWA CITY,IA 52242. RP FISHER, CJ (reprint author), CLEVELAND CLIN FDN,DEPT PULM & CRIT CARE MED,CRIT CARE RES UNIT,G62-60,9500 EUCLID AVE,CLEVELAND,OH 44195, USA. NR 23 TC 33 Z9 33 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0092-6213 J9 CIRC SHOCK JI Circ. Shock PD SEP PY 1994 VL 44 IS 1 BP 1 EP 8 PG 8 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA QJ723 UT WOS:A1994QJ72300001 PM 7704933 ER PT J AU VAUGHN, RB SAIEDIAN, H UNGER, EA AF VAUGHN, RB SAIEDIAN, H UNGER, EA TI A PROPOSED MECHANISM FOR IMPLEMENTATION OF NON-DISCRETIONARY ACCESS CONTROLS IN A NETWORK ENVIRONMENT SO COMPUTER NETWORKS AND ISDN SYSTEMS LA English DT Article DE NON-DISCRETIONARY ACCESS CONTROLS; OFFICE SYSTEMS; REFERENCE MONITOR; DISTRIBUTED SYSTEMS; SECURITY MECHANISMS; SENTINEL ID SECURITY AB This paper investigates moving Lampson's reference monitor abstraction from the single system environment to a range of networked distributed systems which include interconnected office information systems. It suggests modifying our implementation of the abstraction from the traditional security kernel to a dual approach using a basic, node level reference monitor and a system level reference monitor that we choose to call a sentinel. An argument is presented that the sentinel meets the requirements of a reference monitor in that it provides separation, mediation, and can be formally verified. The approach to installing a sentinel is viewed as top down with great emphasis on the security mode implemented at each participating node. C1 USA,CTR INFORMAT SYST,FT BELVOIR,VA 22060. UNIV NEBRASKA,DEPT COMP SCI,OMAHA,NE 68182. KANSAS STATE UNIV AGR & APPL SCI,MANHATTAN,KS 66506. RI Saiedian, Hossein/C-5608-2014 NR 15 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-7552 J9 COMPUT NETWORKS ISDN JI Comput. Netw. ISDN Syst. PD SEP PY 1994 VL 26 IS 12 BP 1523 EP 1531 DI 10.1016/0169-7552(94)90026-4 PG 9 WC Computer Science, Information Systems; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA PF471 UT WOS:A1994PF47100004 ER PT J AU BRAR, GS STEWART, BA AF BRAR, GS STEWART, BA TI GERMINATION UNDER CONTROLLED TEMPERATURE AND FIELD EMERGENCE OF 13 SORGHUM CULTIVARS SO CROP SCIENCE LA English DT Article ID ESTABLISHMENT AB Temperature and cultivar strongly influence the establishment of dryland sorghum [Sorghum bicolor (L) Moench]. Little is known about the extent of variability in germination and emergence among different sorghum cultivars as affected by temperature. Our objective was to monitor cultivars for germination under different temperature regimes in the laboratory, and subsequently to test their performance in the field for emergence. Sorghum seeds were screened for germination during 10 d in polyethylene growth pouches held in the dark at constant temperatures of 10, 15.5, 21, 26.5, 32, or 37.5 degrees C. In the field study, 13 hybrids were planted on 4, 13, 21, and 26 June 1991, and observed for emergence. Germination percentage significantly (P < 0.05) increased as temperature of treatment increased from 15.5 to 26.5 or 32 degrees C when averaged across the cultivars, with no germination at 10 degrees C. As temperature increased from 15.5 to 37.5 degrees C the average time to germination decreased significantly (P < 0.05). Cultivar Richardson-9112 had the greatest germination percentage (98%) and DK-46, as well as DK-42, had the least (79%) when averaged across the five temperatures. For 80% or above of the seeds to germinate, it required 7 d at 15.5, 3 d at 21, 2 d at 26.5 and 32, and 1 d at 37.5 degrees C temperature. An optimum temperature of the cultivars investigated varied between 26.5 and 32 degrees C. Mean held emergence was significantly (P < 0.05) greatest (83%) with Richardson-9112 and least (36%) with DK-42Y as well as DK96 compared to nine cultivars. Relative mean emergence in the held regressed with relative mean germination in the laboratory yielded a significant (P < 0.05) correlation (r(2) = 0.77). This study demonstrates the cultivar differences for response to temperature and information concerning variability in germination, and emergence. C1 W TEXAS AM UNIV,INST DRYLAND AGR,CANYON,TX 79016. RP BRAR, GS (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03555, USA. NR 16 TC 23 Z9 23 U1 0 U2 1 PU CROP SCIENCE SOC AMER PI MADISON PA 677 S SEGOE ROAD, MADISON, WI 53711 SN 0011-183X J9 CROP SCI JI Crop Sci. PD SEP-OCT PY 1994 VL 34 IS 5 BP 1336 EP 1340 PG 5 WC Agronomy SC Agriculture GA PF016 UT WOS:A1994PF01600036 ER PT J AU COOTS, NV BAUNCHALK, JM FELDMAN, AR NADJEM, MA AF COOTS, NV BAUNCHALK, JM FELDMAN, AR NADJEM, MA TI FOCAL MYOSITIS IN A PATIENT WITH BILATERAL PAINFUL NODULES SO CUTIS LA English DT Article AB A 30-year-old African-American man presented with painful lower extremities and bilaterally symmetrical dermal nodules. Examination of a biopsy specimen of one of the nodules showed focal myositis overlying a deeper defect. Subsequent excisions produced multifocal eruptive lipomas. The histopathologic findings of focal myositis are reviewed along with this previously unreported association. C1 BROOKE ARMY MED CTR,DERMATOL SERV,FT SAM HOUSTON,TX 78234. WILLIAM BEAUMONT ARMY MED CTR,PATHOL SERV,EL PASO,TX 79920. NR 7 TC 3 Z9 3 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0011-4162 J9 CUTIS JI Cutis PD SEP PY 1994 VL 54 IS 3 BP 189 EP 190 PG 2 WC Dermatology SC Dermatology GA PG256 UT WOS:A1994PG25600012 PM 7813241 ER PT J AU FINSTUEN, K NICHOLS, S HOFFMAN, P AF FINSTUEN, K NICHOLS, S HOFFMAN, P TI CORRECTION TO A CORRECTION FACTOR AND IDENTIFICATION OF HYPOTHESES FOR ONE-WAY ANOVA FROM SUMMARY STATISTICS SO EDUCATIONAL AND PSYCHOLOGICAL MEASUREMENT LA English DT Article AB Computation of a one-way analysis of variance (ANOVA) F ratio from descriptive statistics in the absence of raw data is corrected from two sources. Means associated with inferential statistical hypotheses are identified as estimable population parameters. C1 USN,WASHINGTON,DC 20350. RP FINSTUEN, K (reprint author), USA,MED DEPT CTR & SCH,BAYLOR UNIV GRAD PROGRAM HLTH CARE ADM,DIV HLTH,FT SAM HOUSTON,TX 78234, USA. NR 3 TC 0 Z9 0 U1 1 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 SN 0013-1644 J9 EDUC PSYCHOL MEAS JI Educ. Psychol. Meas. PD FAL PY 1994 VL 54 IS 3 BP 606 EP 607 DI 10.1177/0013164494054003003 PG 2 WC Psychology, Educational; Mathematics, Interdisciplinary Applications; Psychology, Mathematical SC Psychology; Mathematics GA PC981 UT WOS:A1994PC98100003 ER PT J AU SJOGREN, MH AF SJOGREN, MH TI SEROLOGIC DIAGNOSIS OF VIRAL-HEPATITIS SO GASTROENTEROLOGY CLINICS OF NORTH AMERICA LA English DT Article ID NON-B-HEPATITIS; ANTIGEN-ANTIBODY SYSTEM; CHRONIC LIVER-DISEASE; A IGM ANTIBODY; C VIRUS; SURFACE-ANTIGEN; CLINICAL-SIGNIFICANCE; DELTA-HEPATITIS; NATURAL-HISTORY; HBSAG-CARRIERS C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP SJOGREN, MH (reprint author), WALTER REED ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,6800 GEORGIA AVE NW,WASHINGTON,DC 20307, USA. NR 89 TC 7 Z9 7 U1 0 U2 2 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0889-8553 J9 GASTROENTEROL CLIN N JI Gastroenterol. Clin. North Am. PD SEP PY 1994 VL 23 IS 3 BP 457 EP 477 PG 21 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA PE592 UT WOS:A1994PE59200004 PM 7989089 ER PT J AU WHEELER, GA YOUNG, SA AF WHEELER, GA YOUNG, SA TI USE OF METHYLPHENIDATE IN A CASE OF MILD, INOPERATIVE, IDIOPATHIC, NORMAL-PRESSURE HYDROCEPHALUS SO GENERAL HOSPITAL PSYCHIATRY LA English DT Note ID DEPRESSION C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP WHEELER, GA (reprint author), MONCRIEF ARMY COMMUNITY HOSP,DEPT INTERNAL MED,FT JACKSON,SC 29207, USA. NR 9 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0163-8343 J9 GEN HOSP PSYCHIAT JI Gen. Hosp. Psych. PD SEP PY 1994 VL 16 IS 5 BP 361 EP 363 DI 10.1016/0163-8343(94)90025-6 PG 3 WC Psychiatry SC Psychiatry GA PD004 UT WOS:A1994PD00400010 PM 7995509 ER PT J AU DONAGHE, RT TORREY, VH AF DONAGHE, RT TORREY, VH TI A COMPACTION TEST METHOD FOR SOIL-ROCK MIXTURES IN WHICH EQUIPMENT SIZE EFFECTS ARE MINIMIZED SO GEOTECHNICAL TESTING JOURNAL LA English DT Article DE SOIL-ROCK COMPACTION TESTS; LABORATORY TESTS; SOIL-ROCK MIXTURES; COMPACTION CHARACTERISTICS; IMPACT COMPACTION; STANDARD EFFORT; EQUIPMENT SIZE EFFECTS; MAXIMUM DRY UNIT WEIGHT; OPTIMUM WATER CONTENT AB The development of a standard effort compaction test method for determining compaction characteristics of soil-rock mixtures having maximum particle sizes up to 51 or 76 mm (2 or 3 in.) is described. The method is based on results of a testing program to develop testing procedures for 305 and 457-mm (12 and 18-in.)-diameter molds in which equipment size effects are minimized, i.e., procedures where results for materials tested using a conventional 152-mm (6-in.)-diameter mold may be reproduced with the larger equipment required to test materials having maximum particles sizes of 51 and 76 mm (2 and 3 in.). The testing program consisted of a series of standard effort compaction tests performed using 152, 305, and 457-mm (6, 12, and 18-in.)-diameter molds on four test materials having a maximum particle size of 19.1 mm (3/4 in.) and either plastic or nonplastic fines. Hammer weight was isolated as the main testing variable for use in developing the procedure while maintaining as many features of the conventional procedure as possible. It was found that in the case of 305-mm (12-in.)-diameter mold tests, varying hammer weight did not produce significant effects on results and that 152-mm (6-in.)-diameter mold results could be reproduced with any of the hammers used. In the case of the 457-mm (18-in.)-diameter mold, it was found that 152-mm (6-in.)-diameter mold results could be reproduced with the heaviest hammer [59.6 kg (131.4-lbf) used in the 305-mm (12-in.)-diameter mold tests]. The test method resulting from the investigation utilizes a mechanical compactor equipped with 305 and 457-mm (12 and 18-in.)-diameter molds and a 59.6-kg (131.4-lbf) hammer with a 305-mm (12-in.) drop. Additional tests performed using the test method on minus No. 4 (4.76-mm) sieve fractions of the 19.1-mm (3/4-in.) maximum particle size materials produced significant differences in results due to varying equipment sizes, thus indicating it may be impossible to minimize equipment size effects to the same extent for finer gradations. RP DONAGHE, RT (reprint author), USA,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 8 TC 5 Z9 6 U1 0 U2 6 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0149-6115 J9 GEOTECH TEST J JI Geotech. Test. J. PD SEP PY 1994 VL 17 IS 3 BP 363 EP 370 PG 8 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA PL907 UT WOS:A1994PL90700010 ER PT J AU TORREY, VH DONAGHE, RT AF TORREY, VH DONAGHE, RT TI COMPACTION CONTROL OF EARTH-ROCK MIXTURES - A NEW APPROACH SO GEOTECHNICAL TESTING JOURNAL LA English DT Article DE SOILS; ROCKS; COMPACT TESTS; SOIL-ROCK MIXTURES; COMPACTION CONTROL; MAXIMUM DRY UNIT WEIGHT; OPTIMUM WATER CONTENT AB A new method for compaction control of earth-rock mixtures has been developed which permits the calculations of the maximum dry unit weight and optimum water content of the total material from corresponding values obtained on either the minus 3/4-in. (19.1-mm) or the minus No. 4(4.76-mm) fraction. The new concepts are substantiated by showing their applicability to a wide range of gradations of earth-rock mixtures tested by the U.S. Army Engineer Waterways Experiment Station and other previous investigators. Calculations of maximum dry unit weight and optimum water content of the total material from corresponding values for a fraction are made using a density interference coefficient and optimum water content factor which are shown to be linearly related to gravel content in the material in log-log coordinates. It is also shown that if a sufficient range in gravel content exists in the minus 3/4-in. (19.1-mm) fractions of the total materials, the log-log linear relationships among density interference coefficient, optimum water content factor, and gravel content can usually be obtained without large-scale compaction testing of the parent total materials. In essence, the new method provides project-specific ''rock corrections'' which accurately track the compaction parameters of the entire family of generically related total materials throughout the range in their gravel contents and maximum particle sizes. RP TORREY, VH (reprint author), USA,ENGINEERS WATERWAYS EXPT STN,GEOTECH LAB,VICKSBURG,MS 39180, USA. NR 11 TC 6 Z9 6 U1 3 U2 6 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0149-6115 J9 GEOTECH TEST J JI Geotech. Test. J. PD SEP PY 1994 VL 17 IS 3 BP 371 EP 386 PG 16 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA PL907 UT WOS:A1994PL90700011 ER PT J AU DONAGHE, RT TORREY, VH AF DONAGHE, RT TORREY, VH TI PROPOSED NEW STANDARD TEST METHOD FOR LABORATORY COMPACTION TESTING OF SOIL-ROCK MIXTURES USING STANDARD EFFORT SO GEOTECHNICAL TESTING JOURNAL LA English DT Article DE SOIL-ROCK COMPACTION; COMPACTION CHARACTERISTICS; IMPACT COMPACTION; STANDARD EFFORT; MAXIMUM DRY UNIT WEIGHT; OPTIMUM WATER CONTENT; COMPACTION CURVE AB The purpose of this proposed standard is to standardize a test method for determining standard effort compaction characteristics of soil-rock mixtures containing particles larger than the 3/4-in. (19.0-mm) sieve and finer than the 3-in. (76.2-mm) sieve. The proposed method utilizes a mechanical compactor equipped with a 12-in.(304.8-mm) or 18-in. (457.2-mm)-diameter mold and a 131.4-lbf (584.5-N) rammer dropped from a height of 12 in. (304.8 mm). RP DONAGHE, RT (reprint author), USA,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 0 TC 3 Z9 3 U1 0 U2 3 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0149-6115 J9 GEOTECH TEST J JI Geotech. Test. J. PD SEP PY 1994 VL 17 IS 3 BP 387 EP 392 PG 6 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA PL907 UT WOS:A1994PL90700012 ER PT J AU FLEMING, T AF FLEMING, T TI FTIR SPECTROSCOPY SHOWS PROMISE FOR MEASURING IN-SITU SOIL CONTAMINATION SO HAZARDOUS WASTE CONSULTANT LA English DT Article RP FLEMING, T (reprint author), USA,CORPS ENGINEERS,VICKSBURG DIST,CELMK OD M,2101 N FRONTAGE RD,VICKSBURG,MS 39180, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0738-0232 J9 HAZARDOUS WASTE CONS JI Hazard. Waste Consult. PD SEP-OCT PY 1994 VL 12 IS 5 BP A28 EP A29 PG 2 WC Engineering, Environmental SC Engineering GA PH703 UT WOS:A1994PH70300010 ER PT J AU GIBBONS, JM HOKE, SH AF GIBBONS, JM HOKE, SH TI CAPILLARY ZONE ELECTROPHORESIS WITH INDIRECT UV DETECTION - DETERMINATION OF SODIUM DODECYL-SULFATE IN SIMULATED STREAM WATER SO HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY LA English DT Article DE CAPILLARY ZONE ELECTROPHORESIS; INDIRECT UV DETECTION; SODIUM DODECYL SULFATE ID ANIONIC SURFACTANTS; ION-PAIR; EXTRACTION AB SDS (sodium dodecyl sulfate) has been quantitatively determined by capillary zone electrophoresis using a fused silica capillary and a 5 mM dihydroxybenzoic acid / sodium hydroxide buffer in 5% methanol solution at a pH of 8.1. The ion was detected by indirect UV absorption at 250 nm. Detection range was from 0.8 to 50 mg SDS/L. This rapid method requiring only small sample volumes was developed in support of an aquatic toxicology study in a simulated stream water and is applicable to waters containing common inorganic ions. C1 USA,BIOMED RES & DEV LAB,FT DETRICK,MD 21702. NR 10 TC 11 Z9 11 U1 0 U2 1 PU DR ALFRED HUTHIG VERLAG GMBH PI HEIDELBERG 1 PA POSTFACH 102869, W-69018 HEIDELBERG 1, GERMANY SN 0935-6304 J9 HRC-J HIGH RES CHROM JI HRC-J. High Resolut. Chromatogr. PD SEP PY 1994 VL 17 IS 9 BP 665 EP 667 PG 3 WC Chemistry, Analytical SC Chemistry GA PK729 UT WOS:A1994PK72900009 ER PT J AU PAYNE, DG PETERS, LJ BIRKMIRE, DP BONTO, MA ANASTASI, JS WENGER, MJ AF PAYNE, DG PETERS, LJ BIRKMIRE, DP BONTO, MA ANASTASI, JS WENGER, MJ TI EFFECTS OF SPEECH-INTELLIGIBILITY LEVEL ON CONCURRENT VISUAL TASK-PERFORMANCE SO HUMAN FACTORS LA English DT Article ID INDIVIDUAL-DIFFERENCES; ATTENTION; ACCIDENTS; BEHAVIOR; WORKLOAD AB Four experiments were performed to determine if changes in the level of speech intelligibility in an auditory task have an impact on performance in concurrent visual tasks. The auditory task used in each experiment was a memory search task in which subjects memorized a set of words and then decided whether auditorily presented probe items were members of the memorized set. The visual tasks used were an unstable tracking task, a spatial decision-making task, a mathematical reasoning task, and a probability monitoring task. Results showed that performance on the unstable tracking and probability monitoring tasks was unaffected by the level of speech intelligibility on the auditory task, whereas accuracy in the spatial decision-making and mathematical processing tasks was significantly worse at low speech intelligibility levels. The findings are interpreted within the framework of multiple resource theory. C1 USA,TRIPLER ARMY MED CTR,HONOLULU,HI. USA,HUMAN RES LAB,HUMAN ENGN DIRECTORATE,ABERDEEN PROVING GROUND,MD 21010. RP PAYNE, DG (reprint author), SUNY BINGHAMPTON,DEPT PSYCHOL,BINGHAMTON,NY 13902, USA. NR 42 TC 9 Z9 9 U1 0 U2 0 PU HUMAN FACTORS SOC PI SANTA MONICA PA BOX 1369, SANTA MONICA, CA 90406 SN 0018-7208 J9 HUM FACTORS JI Hum. Factors PD SEP PY 1994 VL 36 IS 3 BP 441 EP 475 PG 35 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA PL892 UT WOS:A1994PL89200004 PM 7989051 ER PT J AU WOGALTER, MS JARRARD, SW SIMPSON, SN AF WOGALTER, MS JARRARD, SW SIMPSON, SN TI INFLUENCE OF WARNING LABEL SIGNAL WORDS ON PERCEIVED HAZARD LEVEL SO HUMAN FACTORS LA English DT Article ID PERCEPTION AB This experiment investigated the influence of warnings, signal words, and a signal icon on perceived hazard of consumer products. Under the guise of a marketing research study, 135 people (high school students, college students, and participants from a shopping mall) rated product labels on six dimensions, including how hazardous they perceived the products to be. A total of 16 labels from actual household products were used: 9 carried the experimental conditions, and 7 were filler product labels that never carried a warning. Five conditions presented the signal words NOTE, CAUTION, WARNING, DANGER, and LETHAL together with a brief warning message. In another two conditions, a signal icon (exclamation point surrounded by a triangle) was presented together with the terms DANGER and LETHAL. In the final two conditions, one lacked a signal word but retained the warning message, and the other lacked both the warning message and the signal word. Results showed that the presence of a signal word increased perceived product hazard compared with its absence. Significant differences were noted between extreme terms (e.g., NOTE and DANGER) but not between terms usually recommended in warning design guidelines (e.g., CAUTION and WARNING). The signal icon showed no significant effect on hazard perception. Implications of the results and the value of the methodology for future warnings investigations are discussed. C1 US MIL ACAD,W POINT,NY 10996. RENSSELAER POLYTECH INST,TROY,NY 12181. RP WOGALTER, MS (reprint author), N CAROLINA STATE UNIV,DEPT PSYCHOL,POE HALL,CAMPUS BOX 7801,RALEIGH,NC 27695, USA. NR 22 TC 21 Z9 21 U1 3 U2 5 PU HUMAN FACTORS SOC PI SANTA MONICA PA BOX 1369, SANTA MONICA, CA 90406 SN 0018-7208 J9 HUM FACTORS JI Hum. Factors PD SEP PY 1994 VL 36 IS 3 BP 547 EP 556 PG 10 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA PL892 UT WOS:A1994PL89200010 PM 7989055 ER PT J AU KILLEN, A TARRANT, D JENSEN, D AF KILLEN, A TARRANT, D JENSEN, D TI HIGH ACCELERATION, HIGH-PERFORMANCE SOLID-STATE ACCELEROMETER DEVELOPMENT SO IEEE AEROSPACE AND ELECTRONIC SYSTEMS MAGAZINE LA English DT Article AB This paper presents current accomplishments in the development of a high performance, high g, tactical accelerometer for use in the Advanced Kinetic Energy Missile (AdKEM) development program being conducted by the US Army Missile Command. The design goals of the accelerometer are to provide strapdown tactical navigation quality acceleration information throughout a 20 g soft launch phase, 1200 g boost phase, and low-g coast phase environment. The accelerometers must be able to provide acceleration measurements accurate enough to provide a navigational accuracy of 0.5 meter CEP at 500 meters. This translates to an accelerometer capable of measuring a 1200 g acceleration with a resolution of 1 milli-g. The AdKEM missile accelerometer and gyro outputs are used for control stability and midcourse guidance. The successful demonstration of this device offers a myriad of opportunities in both the commercial and military arenas. The operational environment and performance characteristics of the AdKEM accelerometer will be presented. This accelerometer is unique in the fact that it must not only survive but successfully operate through the 1200 g acceleration environment, while providing sufficient sensitivity to resolve applied accelerations down to a 1 milli-g level. This large 1.2 x 10(6) dynamic range is new for tactical missiles, where dynamic ranges of 10(4) are typical. Strategic missiles and position location applications have required similarly high dynamic ranges; however, this application is unique in acceleration range of milli-g's to g's. Other design requirements imposed on this accelerometer for viability in a tactical application are: minimum cost, size, weight and power consumption and survivability over a wide range operating environment. Crystalline quartz vibrating beam technology has been chosen for this accelerometer application to take advantage of solid state device characteristics. A solid state device with inherently digital output characteristics is desirable for strapdown navigation applications because of interface circuitry simplification, potential lower cost, inherent stability and longer storage life. C1 ALLIEDSIGNAL AEROSP,INSTRUMENT SYST,REDMOND,WA 98073. RP KILLEN, A (reprint author), USA,MISSILE COMMAND,GUIDANCE & CONTROL DIRECTORATE,INERTIAL SYST DEV BRANCH,REDSTONE ARSENAL,AL 35898, USA. NR 0 TC 1 Z9 3 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-8985 J9 IEEE AERO EL SYS MAG JI IEEE Aerosp. Electron. Syst. Mag. PD SEP PY 1994 VL 9 IS 9 BP 20 EP 25 DI 10.1109/62.312975 PG 6 WC Engineering, Aerospace; Engineering, Electrical & Electronic SC Engineering GA PG046 UT WOS:A1994PG04600007 ER PT J AU BRAUNSTEIN, J SALON, S LIBELO, L SCHLESIGER, CD AF BRAUNSTEIN, J SALON, S LIBELO, L SCHLESIGER, CD TI ANALYSIS OF FLARED END FOR VLASOV-TYPE ANTENNA - COMPARISON OF 2D FINITE-ELEMENT ANALYSIS WITH EXPERIMENT SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT 9th Conference on the Computation of Electromagnetic Fields (COMPUMAG 93) CY OCT 31-NOV 04, 1993 CL MIAMI, FL SP DIGITAL EQUIPMENT CORP, USA, VECTOR FIELDS INC, UK, INFOLYTICA CORP, CANADA, GE TRANSPORTAT SYST, USA, IBM CORP, USA, ALPS ELECT CO LTD, JAPAN, ANSOFT CORP, USA, BATH UNIV, APPL ELECTROMAGNET CTR, UK, DAEWOO ELECTR CO, KOREA, HYOSUNG IND CO, KOREA, INTEGRATED ENGN SOFTWARE INC, KOREA, MATSUSHITA ELECT IND CO LTD, JAPAN, SAMSUNG ELECTRO MECH, KOREA, SWANSEN ANAL SYST, USA, FLORIDA INT UNIV, USA AB Improved beam focusing of high powered microwaves radiating from a Vlasov-type antenna be achieved by applying a flare to the launcher aperture. A frequency domain two dimensional hybrid finite-boundary element model solves the near field time harmonic wave equation. Linear interpolation of boundary magnetic and electric fields is used for the Hankel function approximation of the far field. Three significant advantages are noticed with flare application: (a) beam narrowing, with increased center peak intensity, (b) reduction in side-lobe fields, and (c) increased mode purity in the waveguide. Results are in agreement with experimental data. C1 USA,RES LABS,ADELPHI,MD 20783. RP BRAUNSTEIN, J (reprint author), RENSSELAER POLY INST,TROY,NY 12180, USA. NR 6 TC 1 Z9 3 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD SEP PY 1994 VL 30 IS 5 BP 3120 EP 3123 DI 10.1109/20.312598 PN 2 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA PD542 UT WOS:A1994PD54200066 ER PT J AU TAIT, GB AF TAIT, GB TI MICROWAVE MIXERS EMPLOYING MULTIPLE BARRIER SEMICONDUCTOR HETEROSTRUCTURE DEVICES SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article ID ALLOY RAMP HETEROSTRUCTURES; DIODES AB Experimental data on mixer performance of unipolar semiconductor heterostructure diodes containing bulk alloy-ramp barriers are presented. Prototype Al(x)Ga1-xAs/GaAs heterostructures containing one, two, and four barriers are fabricated by MBE and tested in a single-ended mixer circuit at 10 GHz. The devices with two and four barriers, which exhibit improved performance over the single-barrier device, achieve conversion losses between 4 and 6 dB and noise temperature ratios between 1.5 and 2 at 300 K. Several significant advantages over contending Schottky diodes are also discussed. The results indicate that multiple-barrier devices are good candidates for use in microwave and millimeter-wave mixer circuits. C1 USN,RES LAB,DIV ELECTR SCI & TECHNOL,MICROWAVE TECHNOL BRANCH,WASHINGTON,DC 20375. UNIV VIRGINIA,DEPT ELECT ENGN,CHARLOTTESVILLE,VA 22903. RP TAIT, GB (reprint author), US MIL ACAD,DEPT ELECT ENGN,W POINT,NY 10996, USA. NR 10 TC 2 Z9 2 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD SEP PY 1994 VL 42 IS 9 BP 1596 EP 1601 DI 10.1109/22.310551 PN 1 PG 6 WC Engineering, Electrical & Electronic SC Engineering GA PE807 UT WOS:A1994PE80700002 ER PT J AU TORRIERI, D AF TORRIERI, D TI CALCULATION OF NODE-PAIR RELIABILITY IN LARGE NETWORKS WITH UNRELIABLE NODES SO IEEE TRANSACTIONS ON RELIABILITY LA English DT Article DE NODE-PAIR RELIABILITY; UNRELIABLE NODE; NETWORK RELIABILITY AB A new efficient method that compensates for unreliable nodes in network reliability computations is presented. This method can be embedded in the modified Dotson algorithm or any algorithm that generates a symbolic reliability expression for networks with perfect nodes. Its cost increases linearly with the number of links, and the effect of unreliable nodes can be directly computed. This method supplants the Aggarwal method and other methods of compensating for unreliable nodes in the calculation of node-pair reliability. When combined with the modified Dotson algorithm, this method provides accurate reliability estimates for networks so large that tbe Theologou-Carlier algorithm cannot complete its computations in a reasonable amount of time. For such networks, the new method can be embedded in the modified Dotson algorithm to estimate both the node-pair reliability and the error in this estimate even if the algorithm is terminated before completion. RP TORRIERI, D (reprint author), USA,AMSRL SS IB,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 5 TC 44 Z9 50 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9529 J9 IEEE T RELIAB JI IEEE Trans. Reliab. PD SEP PY 1994 VL 43 IS 3 BP 375 EP & DI 10.1109/24.326428 PG 0 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering; Engineering, Electrical & Electronic SC Computer Science; Engineering GA PL935 UT WOS:A1994PL93500006 ER PT J AU YIN, JS SILIO, CB AF YIN, JS SILIO, CB TI K-TERMINAL RELIABILITY IN RING NETWORKS SO IEEE TRANSACTIONS ON RELIABILITY LA English DT Article DE K-TERMINAL RELIABILITY; TOKEN RING; FIBER DISTRIBUTED DATA INTERFACE (FDDI); CONCENTRATOR TREE; DUAL RING; RING OF TREES; POLYNOMIAL EXPRESSION AB We present a new formula for computing K-terminal reliability in a communication network whose stations and links (vertices and edges) form a network graph G having a ring topology, where K-terminal reliability is the probability R(K)(G) that a subset of K specific terminal stations in G can communicate, Ring network operation requires that links and stations in G form a complete cycle (circuit), but prior work relies on the enumeration of spanning trees with cycle-free paths to obtain K-graphs and their dominations in computing RK(G). We apply this new formula to three Fiber Distributed Data Interface (FDDI) ring-network topologies, and for each topology we derive closed-form polynomial expressions of R(K)(G) in terms of the failure probabilities of links, network ports, and station common units. The three topologies are: 1) a tree of wiring concentrators and terminal stations, 2) a counter-rotating dual ring, and 3) a counterrotating dual ring of concentrator trees. For simplicity they are called trees, counter-rotating dual rings, and rings of trees, respectively; however, each topology operates as a single unidirectional (simplex) ring that responds to a fault by attempting to reconfigure itself to provide continued, failsoft operation, We define the concept of K-minimal Eulerian circuit and use combinations of these circuits to obtain K-graphs and their resulting dominations, thus extending the use of K-graphs to ring networks in which data messages, tokens, or other control frames traverse operative network links with an Eulerian tour, Distinct K-graphs having a nonzero sum of dominations are called noncanceled K-graphs and correspond exactly to terms in closed-form polynomial expressions of R(K)(G). We show that trees have only one K-graph and that counter-rotating dual rings and rings of trees have at most 2K+1 noncanceled K-graphs. These results contribute the first closed-form polynomial K-terminal reliability expressions for the ring-of-trees topology. The results are useful in evaluating dependability, reliability, availability, or survivability of token rings and similar networks. Because FDDI commercially available components permit a variety of interconnection structures and because of its importance in high speed communications, we use FDDI structures to illustrate both our approach and the applicability of our results. The results apply also to token rings, slotted rings, PLAYTHROUGH rings, and other ring networks that operate using fixed routes for network traffic between the occurrence of reconfiguration events such as startup or fault recovery. Some double-ring protocols permit message transfer on both primary and secondary rings as part of their normal operation and some rings (especially single-ring structures) often use station bypass switches. Our unified formula applies to all such ring networks; however, the resulting K-terminal reliability expressions can be different in each case, depending on the failure remedies used in a particular ring network topology. C1 ADV TECHNOL SYST,VIENNA,AUSTRIA. CENTEL FED SYST,RESTON,VA. INTRAFED INC,BETHESDA,MD. USA,RES LAB,ABERDEEN PROVING GROUND,MD. RP YIN, JS (reprint author), UNIV MARYLAND,DEPT ELECT ENGN,COLLEGE PK,MD 20742, USA. NR 22 TC 6 Z9 7 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9529 J9 IEEE T RELIAB JI IEEE Trans. Reliab. PD SEP PY 1994 VL 43 IS 3 BP 389 EP 401 DI 10.1109/24.326432 PG 13 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering; Engineering, Electrical & Electronic SC Computer Science; Engineering GA PL935 UT WOS:A1994PL93500009 ER PT J AU WALKER, RG AF WALKER, RG TI VIRTUALLY INTERACTIVE BRAINSTORMING SO INDUSTRIAL ENGINEERING LA English DT Editorial Material RP WALKER, RG (reprint author), USA,MED COMMAND PROV,MANPOWER SYST SUPPORT OFF,FT SAM HOUSTON,TX, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU INST INDUSTRIAL ENGINEERS PI NORCROSS PA 25 TECHNOLOGY PARK/ATLANTA, NORCROSS, GA 30092 SN 0019-8234 J9 IND ENG PD SEP PY 1994 VL 26 IS 9 BP 20 EP 21 PG 2 WC Engineering, Industrial SC Engineering GA PE792 UT WOS:A1994PE79200006 ER PT J AU DOOLEY, DP COX, RA HESTILOW, KL DOLAN, MJ MAGEE, DM AF DOOLEY, DP COX, RA HESTILOW, KL DOLAN, MJ MAGEE, DM TI CYTOKINE INDUCTION IN HUMAN COCCIDIOIDOMYCOSIS SO INFECTION AND IMMUNITY LA English DT Article ID TUMOR-NECROSIS-FACTOR; ACQUIRED-IMMUNODEFICIENCY-SYNDROME; RECOMBINANT GAMMA-INTERFERON; FACTOR-ALPHA; ALVEOLAR MACROPHAGES; MURINE MACROPHAGES; ELEVATED LEVELS; SEPTIC SHOCK; CACHECTIN; INFECTION AB To investigate the immune response to human infection with the fungus Coccidioides immitis, we measured cytokine production from peripheral blood mononuclear cells (PBMC) and plastic-adherent monocytes/ macrophages (M phi) isolated from healthy subjects who were skin test positive to spherulin, healthy subjects who were skin test negative, and patients with active coccidioidomycosis. PBMC and M phi from all these donor groups secreted increased levels of tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 in response to stimulation with formalin-killed spherules (FKS), as measured by enzyme-linked immunosorbent assays. Viable C. immitis spherules also stimulated PBMC and M phi from healthy subjects and patients to secrete tumor necrosis factor alpha, interleukin-1 beta, acid interleukin-6, although at levels lower than those induced by FKS. The production of these acute inflammatory cytokines may contribute to the immunopathogenesis of active coccidioidomycosis and could account for the toxicity of the FKS vaccine in humans. C1 TEXAS CTR INFECT DIS,DEPT IMMUNOL RES,SAN ANTONIO,TX 78223. BROOKE ARMY MED CTR,INFECT DIS SERV,FT SAM HOUSTON,TX 78234. WILFORD HALL USAF MED CTR,LACKLAND AFB,TX 78236. NR 33 TC 19 Z9 19 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD SEP PY 1994 VL 62 IS 9 BP 3980 EP 3983 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA PC836 UT WOS:A1994PC83600050 PM 8063416 ER PT J AU BARR, DR BRYSON, MR AF BARR, DR BRYSON, MR TI CORRECTING CASUALTY ESTIMATES SO INTERFACES LA English DT Article DE STATISTICS; ESTIMATION; MILITARY, SYSTEM EFFECTIVENESS; TEST AND EVALUATION AB Data from battle simulations can be used to estimate the causalties in real battles. An instrumentation system measures and records events and variables and controls simulated kills of battle units in military field experiments. After-action reviews show that kills have not always been assessed properly. Since the kills assigned during a trial affect the simulated battle (and the data), the estimates of expected causalties may be incorrect. It is possible to correct initial causalty estimates to account for errors in assessing kills. C1 TEST & EXPERIMENTAT COMMAND,FT HOOD,TX 76544. RP BARR, DR (reprint author), USA,MIL ACAD,W POINT,NY 10996, USA. NR 5 TC 0 Z9 0 U1 0 U2 1 PU INST OPERATIONS RESEARCH MANAGEMENT SCIENCES PI LINTHICUM HTS PA 901 ELKRIDGE LANDING RD, STE 400, LINTHICUM HTS, MD 21090-2909 SN 0092-2102 J9 INTERFACES JI Interfaces PD SEP-OCT PY 1994 VL 24 IS 5 BP 67 EP 76 DI 10.1287/inte.24.5.67 PG 10 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA PP057 UT WOS:A1994PP05700008 ER PT J AU BLANK, S AF BLANK, S TI THE NEW RUSSIA IN THE NEW ASIA SO INTERNATIONAL JOURNAL LA English DT Article RP BLANK, S (reprint author), USA,WAR COLL,STRATEG STUDIES INST,CARLISLE,PA, USA. NR 29 TC 1 Z9 1 U1 0 U2 0 PU CANADIAN INST INTERNAT AFFAIRS PI TORONTO PA 15 KINGS COLLEGE CIRCLE, TORONTO ON M5S 2V9, CANADA SN 0020-7020 J9 INT J JI Int. J. PD FAL PY 1994 VL 49 IS 4 BP 874 EP 907 DI 10.2307/40202979 PG 34 WC International Relations SC International Relations GA QH538 UT WOS:A1994QH53800007 ER PT J AU DANDEKAR, DP AF DANDEKAR, DP TI SHEAR STRENGTHS OF ALUMINUM NITRIDE AND TITANIUM DIBORIDE UNDER PLANE SHOCK-WAVE COMPRESSION SO JOURNAL DE PHYSIQUE IV LA English DT Article; Proceedings Paper CT International Conference on Mechanical and Physical Behaviour of Materials under Dynamic Loading (EURODYMAT 94) CY SEP 26-30, 1994 CL OXFORD, ENGLAND ID ALN AB This work compares the estimates of shear strengths of aluminium nitride and titanium diboride obtained (a) from the simultaneous measurements of longitudinal and lateral stress by means of manganin gauges under plane shock wave loading with (b) those calculated from the offset between hydrodynamic and shock Hugoniot of these materials. The results of this work show that whereas the estimates of the shear strength obtained by these two methods for titanium diboride are consistent with one another, those of aluminium nitride are not. This is at least partly due to the observed inconsistency between the simultaneous measurements of longitudinal and lateral stresses in aluminium nitride. RP DANDEKAR, DP (reprint author), USA,RES LAB,MAT DIRECTORATE,WATERTOWN,MA 02172, USA. NR 17 TC 7 Z9 7 U1 0 U2 1 PU EDITIONS PHYSIQUE PI LES ULIS CEDEX PA Z I DE COURTABOEUF AVE 7 AV DU HOGGAR, BP 112, 91944 LES ULIS CEDEX, FRANCE SN 1155-4339 J9 J PHYS IV JI J. Phys. IV PD SEP PY 1994 VL 4 IS C8 BP 379 EP 384 DI 10.1051/jp4:1994858 PG 6 WC Physics, Multidisciplinary SC Physics GA PZ056 UT WOS:A1994PZ05600059 ER PT J AU LEE, CK AF LEE, CK TI RADIAL REEFING METHOD FOR ACCELERATED AND CONTROLLED PARACHUTE OPENING SO JOURNAL OF AIRCRAFT LA English DT Article AB Future Army airdrop systems will require aerial insertion of cargo and personnel from low altitudes to minimize ground-fire hazards. A radial reefing method was developed as a potential candidate to meet this requirement. The radial reefing method involves selecting equally spaced radials of a parachute canopy and reefing these radials near the skirt; concurrently, the canopy fabric adjacent to the reefed radials is puckered. Reefing the canopy this way creates large fabric pockets near the skirt during initial canopy inflation, resulting in an accelerated and controlled parachute opening. This was confirmed by full-scale airdrop testing using single Army personnel and cargo parachutes. In addition to demonstrating promises for single-canopy low-altitude airdrop applications, the radial reefing method also shows potential to improve clustered parachute opening by minimizing canopy enfolding and slumping. RP LEE, CK (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0021-8669 J9 J AIRCRAFT JI J. Aircr. PD SEP-OCT PY 1994 VL 31 IS 5 BP 1124 EP 1129 DI 10.2514/3.46621 PG 6 WC Engineering, Aerospace SC Engineering GA PK523 UT WOS:A1994PK52300019 ER PT J AU ENGLER, RJM DAVIS, WS AF ENGLER, RJM DAVIS, WS TI RUSH HYMENOPTERA VENOM IMMUNOTHERAPY - SUCCESSFUL TREATMENT IN A PATIENT WITH SYSTEMIC MAST-CELL DISEASE SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Note ID YELLOW JACKET VENOM; BEE VENOM; MASTOCYTOSIS; ANAPHYLAXIS; DISORDERS; HISTAMINE C1 UNIV BETHESDA,SCH MED,DEPT MED,BETHESDA,MD. UNIV BETHESDA,SCH MED,PEDIAT UNIFORMED SERV,BETHESDA,MD. RP ENGLER, RJM (reprint author), WALTER REED ARMY MED CTR,ALLERGY IMMUNOL SERV,WASHINGTON,DC 20307, USA. NR 14 TC 22 Z9 23 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD SEP PY 1994 VL 94 IS 3 BP 556 EP 559 DI 10.1016/0091-6749(94)90213-5 PN 1 PG 4 WC Allergy; Immunology SC Allergy; Immunology GA PG907 UT WOS:A1994PG90700016 PM 8083461 ER PT J AU COSMAS, GA AF COSMAS, GA TI IN MANY A STRIFE - GENERAL THOMAS,GERALD,C. AND THE UNITED-STATES-MARINE-CORPS, 1917-1956 - MILLETT,AR SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review RP COSMAS, GA (reprint author), USA,CTR MIL HIST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ORGANIZATION AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD SEP PY 1994 VL 81 IS 2 BP 765 EP 766 DI 10.2307/2081345 PG 2 WC History SC History GA PG528 UT WOS:A1994PG52800182 ER PT J AU CRANE, CC AF CRANE, CC TI JOINT AIR OPERATIONS - PURSUIT OF UNITY IN COMMAND AND CONTROL, 1942-1991 - WINNEFELD,JA, JOHNSON,DJ SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review RP CRANE, CC (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ORGANIZATION AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD SEP PY 1994 VL 81 IS 2 BP 790 EP 791 DI 10.2307/2081374 PG 2 WC History SC History GA PG528 UT WOS:A1994PG52800212 ER PT J AU SUHAN, M CHEN, SY THOMPSON, HA HOOVER, TA HILL, A WILLIAMS, JC AF SUHAN, M CHEN, SY THOMPSON, HA HOOVER, TA HILL, A WILLIAMS, JC TI CLONING AND CHARACTERIZATION OF AN AUTONOMOUS REPLICATION SEQUENCE FROM COXIELLA-BURNETII SO JOURNAL OF BACTERIOLOGY LA English DT Article ID ESCHERICHIA-COLI K-12; DEOXYRIBONUCLEIC-ACID; NUCLEOTIDE-SEQUENCE; DNA-REPLICATION; LYSOSOMAL RESPONSE; BACILLUS-SUBTILIS; EXONUCLEASE-III; POLYMERASE I; PLASMID DNA; L-CELLS AB A Coxiella burnetii chromosomal fragment capable of functioning as an origin for the replication of a kanamycin resistance (Kan(r)) plasmid was isolated by use of origin search methods utilizing an Escherichia coli host. The 5.8-kb fragment was subcloned into phagemid vectors and was deleted progressively by an exonuclease III-S1 technique. Plasmids containing progressively shorter DNA fragments were then tested for their capability to support replication by transformation of an E. coli polA strain. A minimal autonomous replication sequence (ARS) was delimited to 403 bp. Sequencing of the entire 5.8-kb region revealed that the minimal ARS contained two consensus DnaA boxes, three A+T-rich 21-mers, a transcriptional promoter leading rightwards, and potential integration host factor and factor of inversion stimulation binding sites. Database comparisons of deduced amino acid sequences revealed that open reading frames located around the ARS were homologous to genes often, but not always, found near bacterial chromosomal origins; these included identities with rpmH and mpA in E. coli and identities with the 9K protein and 60K membrane protein in E. coli and Pseudomonas species. These and direct hybridization data suggested that the ARS was chromosomal and not associated with the resident plasmid QpH1. Two-dimensional agarose gel electrophoresis aid not reveal the presence of initiating intermediates, indicating that the ARS did not initiate chromosome replication during laboratory growth of C. burnetii. C1 W VIRGINIA UNIV, HLTH SCI CTR, DEPT IMMUNOL & MICROBIOL, MORGANTOWN, WV 26506 USA. USA, MED RES INST INFECT DIS, DEPT INTRACELLULAR PATHOGENS, DIV BACTERIOL, FREDERICK, MD 21701 USA. FU NCRR NIH HHS [2SO7RRO5433] NR 76 TC 31 Z9 38 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0021-9193 EI 1098-5530 J9 J BACTERIOL JI J. Bacteriol. PD SEP PY 1994 VL 176 IS 17 BP 5233 EP 5243 PG 11 WC Microbiology SC Microbiology GA PD457 UT WOS:A1994PD45700006 PM 8071197 ER PT J AU JAPOUR, AJ FISCUS, SA ARDUINO, JM MAYERS, DL REICHELDERFER, PS KURITZKES, DR AF JAPOUR, AJ FISCUS, SA ARDUINO, JM MAYERS, DL REICHELDERFER, PS KURITZKES, DR TI STANDARDIZED MICROTITER ASSAY FOR DETERMINATION OF SYNCYTIUM-INDUCING PHENOTYPES OF CLINICAL HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ISOLATES SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Note ID HIV-1 BIOLOGICAL PHENOTYPE; ZIDOVUDINE RESISTANCE; DISEASE PROGRESSION; CELL-CULTURE; INFECTION; AIDS; INDIVIDUALS; TROPISM; CLONES; MT-2 AB A standardized assay in 96-well microtiter plates for syncytium-inducing (SI) human immunodeficiency virus type 1 phenotype detection using MT-2 cells has been developed. SI variants were found in 67% of the patients with advanced human immunodeficiency virus disease. The occurrence of the SI phenotype increased with lower CD4(+) counts. There was no association between p24 antigenemia and the SI phenotype. C1 HARVARD UNIV,SCH MED,BOSTON,MA 02215. UNIV N CAROLINA,DEPT MICROBIOL & IMMUNOL,CHAPEL HILL,NC 27599. WALTER REED ARMY INST RES,DEPT HIV DRUGS & GENE THERAPY,ROCKVILLE,MD 20850. NIAID,DIV AIDS,BETHESDA,MD 20892. UNIV COLORADO,HLTH SCI CTR,DIV INFECT DIS,DENVER,CO 80262. VET AFFAIRS MED CTR,DENVER,CO 80262. USN,INST MED RES,ROCKVILLE,MD. HARVARD UNIV,SCH PUBL HLTH,CTR STAT DATA ANAL,BOSTON,MA 02215. RP JAPOUR, AJ (reprint author), BETH ISRAEL HOSP,DEPT MED,DIV INFECT DIS,DANA 617,330 BROOKLINE AVE,BOSTON,MA 02215, USA. FU NIAID NIH HHS [AI 27659, AI 25868, AI 01101] NR 19 TC 79 Z9 79 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD SEP PY 1994 VL 32 IS 9 BP 2291 EP 2294 PG 4 WC Microbiology SC Microbiology GA PB541 UT WOS:A1994PB54100049 PM 7814561 ER PT J AU UHAA, IJ FISHBEIN, DB OLSON, JG RIVES, CC WAAG, DM WILLIAMS, JC AF UHAA, IJ FISHBEIN, DB OLSON, JG RIVES, CC WAAG, DM WILLIAMS, JC TI EVALUATION OF SPECIFICITY OF INDIRECT ENZYME-LINKED-IMMUNOSORBENT-ASSAY FOR DIAGNOSIS OF HUMAN Q-FEVER (VOL 32, PG 1560, 1994) SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Correction, Addition C1 CTR DIS CONTROL & PREVENT,EPIDEMIOL PROGRAM OFF,DIV FIELD EPIDEMIOL,INT BRANCH,ATLANTA,GA 30333. USA,MED RES INST INFECT DIS,DIV BACTERIOL,PATHOGENESIS & IMMUNOL BRANCH,FT DETRICK,MD 21702. US FDA,CTR BIOL EVALUAT & RES,OFF VACCINE RES & REVIEW,DIV VACCINE & RELATED PROD APPLICAT,ROCKVILLE,MD 20852. RP UHAA, IJ (reprint author), CTR DIS CONTROL & PREVENT,NATL CTR INFECT DIS,DIV VIRAL & RICKETTSIAL DIS,ATLANTA,GA 30333, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD SEP PY 1994 VL 32 IS 9 BP 2343 EP 2343 PG 1 WC Microbiology SC Microbiology GA PB541 UT WOS:A1994PB54100072 ER PT J AU MERKEL, KG BRIGHT, VM SCHAUER, SN CASAS, LM WALCK, SD AF MERKEL, KG BRIGHT, VM SCHAUER, SN CASAS, LM WALCK, SD TI ELECTRICAL AND STRUCTURAL-PROPERTIES OF GEMOW OHMIC CONTACT TO AN IN0.5GA0.5AS CAP LAYER ON N-TYPE GAAS SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE GAAS; GEMOW; INGAAS; OHMIC CONTACT; REFRACTORY METALS ID METAL AB The results of electrical and structural characterization of a GeMoW ohmic contact to n-type GaAs with a 100angstrom thick, In0.5Ga0.5As cap layer are presented. Electrical characterization demonstrates ohmic behavior over a wide annealing temperature range from 300 to 700-degrees-C. A minimum contact resistance of 0.176 OMEGA-mm was measured after furnace annealing at 500-degrees-C. The contact resistance is also insensitive to anneal time at 500-degrees-C. Structural characterization using secondary ion mass spectroscopy, Auger electron spectroscopy, and x-ray diffraction indicates excess In as a potential cause of increased contact resistance following 700-degrees-C annealing. C1 USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703. WRIGHT LAB,MAT DIRECTORATE WL MLBT,WRIGHT PATTERSON AFB,OH 45433. RP MERKEL, KG (reprint author), USAF,INST TECHNOL,DEPT ELECT & COMP ENGN,WRIGHT PATTERSON AFB,OH 45433, USA. NR 11 TC 2 Z9 2 U1 0 U2 0 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 420 COMMONWEALTH DR, WARRENDALE, PA 15086 SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD SEP PY 1994 VL 23 IS 9 BP 991 EP 996 DI 10.1007/BF02655375 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA PF342 UT WOS:A1994PF34200024 ER PT J AU GLASS, AR JACKSON, SG PERLSTEIN, RS WRAY, HL AF GLASS, AR JACKSON, SG PERLSTEIN, RS WRAY, HL TI ADRENAL INSUFFICIENCY IN A MAN WITH NONCLASSICAL 21-HYDROXYLASE DEFICIENCY - CONSEQUENCE OR COINCIDENCE SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION LA English DT Note DE ADRENAL INSUFFICIENCY; CONGENITAL ADRENAL HYPERPLASIA ID POLYCYSTIC OVARIAN DISEASE; HYPERPLASIA; HIRSUTISM; GENOTYPE; VARIANT AB Deficiency of the adrenal enzyme 21-hydroxylase, which is required for cortisol synthesis, appears in two forms: a rare classical variant with severe enzyme deficiency, usually presenting in neonates with ambiguous genitalia (from androgen overproduction) or adrenal crisis (from glucocorticoid and mineralocorticoid underproduction), and a common (1% of the general population) non-classical variant with mild enzyme deficiency, usually presenting in young adults with findings of androgen excess but without clinical evidence of decreased steroid hormone production. We describe a 22-year-old man who had clinical and biochemical findings consistent with adrenal insufficiency, including a favorable response to hydrocortisone replacement, in whom elevated serum levels of the cortisol precursor 17-hydroxy progesterone were diagnostic of non classical 21-hydroxylase deficiency and in whom no other cause of adrenal insufficiency could be identified. These findings raise the possibility that nonclassical 21-hydroxylase deficiency, an extremely frequent disorder which is generally thought to be without significant morbidity, might cause or contribute to adrenal insufficiency in adults. RP GLASS, AR (reprint author), WALTER REED ARMY MED CTR,DEPT MED,SERV ENDOCRINOL 7D,WASHINGTON,DC 20307, USA. NR 17 TC 8 Z9 8 U1 0 U2 0 PU EDITRICE KURTIS S R L PI MILANO PA VIA LUIGI ZOJA, 30-20153 MILANO, ITALY SN 0391-4097 J9 J ENDOCRINOL INVEST JI J. Endocrinol. Invest. PD SEP PY 1994 VL 17 IS 8 BP 665 EP 670 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA PM871 UT WOS:A1994PM87100009 PM 7868807 ER PT J AU FAYER, R ELLIS, W AF FAYER, R ELLIS, W TI QINGHAOSU (ARTEMISININ) AND DERIVATIVES FAIL TO PROTECT NEONATAL BALB/C MICE AGAINST CRYPTOSPORIDIUM-PARVUM (CP) INFECTION SO JOURNAL OF EUKARYOTIC MICROBIOLOGY LA English DT Article; Proceedings Paper CT 3rd International Workshops on Opportunistic Protists CY JUN 24-29, 1994 CL CLEVELAND STATE UNIV, CLEVELAND, OH SP SOC OF PROTOZOOLOGIST HO CLEVELAND STATE UNIV C1 WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20006. RP FAYER, R (reprint author), USDA ARS,BELTSVILLE AGR RES CTR,LPSI,BELTSVILLE,MD 20705, USA. NR 2 TC 5 Z9 6 U1 0 U2 0 PU SOC PROTOZOOLOGISTS PI LAWRENCE PA 810 E 10TH ST, LAWRENCE, KS 66044 SN 1066-5234 J9 J EUKARYOT MICROBIOL JI J. Eukaryot. Microbiol. PD SEP-OCT PY 1994 VL 41 IS 5 BP S41 EP S41 PG 1 WC Microbiology SC Microbiology GA PP283 UT WOS:A1994PP28300044 PM 7804241 ER PT J AU SCHODEL, F WIRTZ, R PETERSON, D HUGHES, J WARREN, R SADOFF, J MILICH, D AF SCHODEL, F WIRTZ, R PETERSON, D HUGHES, J WARREN, R SADOFF, J MILICH, D TI IMMUNITY TO MALARIA ELICITED BY HYBRID HEPATITIS-B VIRUS CORE PARTICLES CARRYING CIRCUMSPOROZOITE PROTEIN EPITOPES SO JOURNAL OF EXPERIMENTAL MEDICINE LA English DT Article ID FALCIPARUM SPOROZOITE VACCINE; CD8+ T-CELLS; PLASMODIUM-FALCIPARUM; E-ANTIGEN; SYNTHETIC VACCINE; MURINE MALARIA; IMMUNOGENICITY; ANTIBODIES; SURFACE; BERGHEI AB The hepatitis B virus (HBV) nucleocapsid antigen (HBcAg) was investigated as a carrier moiety for the immunodominant circumsporozoite (CS) protein repeat epitopes of Plasmodium falciparum and the rodent malaria agent P. berghei. For this purpose hybrid genes coding for [NANP](4) (C75CS2) or [DP4NPN](2) (C75CS1) as internal inserts in HBcAg (between amino acids 75 and 81) were constructed and expressed in recombinant Salmonella typhimurium. The resulting hybrid HBcAg-CS polypeptides purified from S. typhimurium were particulate and displayed CS and HBc antigenicity, however, the HBc antigenicity was reduced compared to native recombinant HBcAg. Immunization of several mouse strains with HBcAg-CS1 and HBcAg-CS2 particles resulted in high titer, P. berghei- or P. falciparum-specific anti-CS antibodies representing all murine immunoglobulin G isotypes. The possible influence of carrier-specific immunosuppression was examined, and preexisting immunity to HBcAg did not significantly affect the immunogenicity of the CS epitopes within HBcAg-CS1 particles. Similarly, the choice of adjuvant did not significantly alter the immunogenicity of HBcAg-CS hybrid particles. Immunization in complete or incomplete Freund's adjuvant or alum resulted in equivalent anti-HBc and anti-CS humoral responses. Examination of T cell recognition of HBcAg-CS particles revealed that HBcAg-specific T cells were universally primed and CS-specific T cells were primed if the insert contained a CS-specific T cell recognition site. This indicates that the internal site in HBcAg is permissive for the inclusion of heterologous pathogen-specific T as well as B cell epitopes. Most importantly, 90 and 100% of BALB/c mice immunized with HBcAg-CS1 particles were protected against a P. berghei challenge infection in two independent experiments. Therefore, hybrid HBcAg-CS particles may represent a useful approach for future malaria vaccine development. C1 WALTER REED ARMY INST RES, DEPT BACTERIAL DIS, WASHINGTON, DC 20307 USA. WALTER REED ARMY INST RES, DEPT ENTOMOL, WASHINGTON, DC 20307 USA. VIRGINIA COMMONWEALTH UNIV, DEPT BIOCHEM, RICHMOND, VA 23298 USA. SCRIPPS RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA. FU NIAID NIH HHS [AI-20720, AI-33562] NR 44 TC 72 Z9 75 U1 0 U2 4 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 SN 0022-1007 J9 J EXP MED JI J. Exp. Med. PD SEP 1 PY 1994 VL 180 IS 3 BP 1037 EP 1046 DI 10.1084/jem.180.3.1037 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA PC938 UT WOS:A1994PC93800026 PM 7520465 ER PT J AU LOWRY, MA MELLEN, PFM WEEDN, VW AF LOWRY, MA MELLEN, PFM WEEDN, VW TI EJECTION SEAT AIRCRAFT FATALITIES IN THE UNITED-STATES MILITARY, 1966 TO 1990 SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE PATHOLOGY AND BIOLOGY; EJECTION SEAT; AVIATION PATHOLOGY; AIRCRAFT ACCIDENT INVESTIGATION; MILITARY AVIATION AB When a military jet aircraft becomes incapable of controlled powered flight, the aircrew has the alternative of initiating the ejection sequence. In a majority of cases the ejection sequence is successful in extracting the aircrew from probable death. However, in a minority of cases the ejected air crew member does not survive. We analyzed 57 autopsy cases from 1966 to 1990 of military aircraft fatalities in which ejection was initiated. These cases were analyzed for injury patterns, age, rank, military branch, type of aircraft and circumstances surrounding the ejection. The majority of fatalities occurred during ''out-of-envelope'' ejections and were associated with extreme whole-body trauma. Drowning fatalities were associated with relatively minor traumatic injury. Parachute malfunctions resulted in extreme total-body decelerative injuries. The remainder of the fatalities were due to man-seat separation failure, human error, and unfortunate circumstances. Two cases of hangman's type cervical neck fracture were observed during high-speed ejection. C1 ARMED FORCES INST PATHOL,OFF ARMED FORCES MED EXAMINER,WASHINGTON,DC. WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC. NR 41 TC 2 Z9 2 U1 0 U2 0 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD SEP PY 1994 VL 39 IS 5 BP 1153 EP 1160 PG 8 WC Medicine, Legal SC Legal Medicine GA PH967 UT WOS:A1994PH96700005 ER PT J AU FARR, MD MILLER, AC BINGHAM, CR AF FARR, MD MILLER, AC BINGHAM, CR TI A DEVICE TO DEPLOY AND ORIENT ARTIFICIAL SUBSTRATES WITHOUT THE NEED FOR DIVERS SO JOURNAL OF FRESHWATER ECOLOGY LA English DT Note ID REEF AB An artificial substrate deployment device (ASDD) was developed to orient and place 30.5 X 30.5 X 5.1 cm concrete blocks used in a macroinvertebrate colonization study in the lower Mississippi River. The ASDD was used in high velocity (ca. 2.5 m/s), moderately deep (ca. 5-8 m), turbid water where divers could not be used. The device could be used effectively to orient and place similar artificial substrates in marine and freshwater habitats inaccessible to divers. C1 NE LOUISIANA UNIV,DEPT BIOL,MONROE,LA 71209. USA,CORPS ENGINEERS,WATERWAYS EXPT STN,ER A,VICKSBURG,MS 39180. NR 5 TC 0 Z9 0 U1 0 U2 1 PU OIKOS PUBL INC PI LA CROSSE PA PO BOX 2558, LA CROSSE, WI 54601 SN 0270-5060 J9 J FRESHWATER ECOL JI J. Freshw. Ecol. PD SEP PY 1994 VL 9 IS 3 BP 257 EP 259 DI 10.1080/02705060.1994.9664893 PG 3 WC Ecology; Limnology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA PN085 UT WOS:A1994PN08500011 ER PT J AU SHARP, JJ PARCHURE, TM AF SHARP, JJ PARCHURE, TM TI SELECTIVE WITHDRAWAL USING CIRCULAR, PARTLY SUBMERGED INTAKE STRUCTURES - CLOSURE SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Discussion C1 USA,ENGINEER WATERWAYS EXPT STN,HYDROL LAB,VICKSBURG,MS 39180. RP SHARP, JJ (reprint author), MEM UNIV NEWFOUNDLAND,FAC ENGN & APPL SCI,ST JOHNS A1B 3X5,NEWFOUNDLAND,CANADA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD SEP PY 1994 VL 120 IS 9 BP 1103 EP 1105 DI 10.1061/(ASCE)0733-9429(1994)120:9(1103) PG 3 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA PD166 UT WOS:A1994PD16600008 ER PT J AU BRYAN, JP TSAREV, SA IQBAL, M TICEHURST, J EMERSON, S AHMED, A DUNCAN, J RAFIQUI, AR MALIK, IA PURCELL, RH LEGTERS, LJ AF BRYAN, JP TSAREV, SA IQBAL, M TICEHURST, J EMERSON, S AHMED, A DUNCAN, J RAFIQUI, AR MALIK, IA PURCELL, RH LEGTERS, LJ TI EPIDEMIC HEPATITIS-E IN PAKISTAN - PATTERNS OF SEROLOGIC RESPONSE AND EVIDENCE THAT ANTIBODY TO HEPATITIS-E VIRUS PROTECTS AGAINST DISEASE SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID LINKED-IMMUNOSORBENT-ASSAY; NON-B-HEPATITIS; TRANSMITTED NON-A; MONOCLONAL-ANTIBODIES; IDENTIFICATION; INFECTION; OUTBREAK; SEROTYPE; ELISA AB IgM and IgG anti-hepatitis E virus (HEV) patterns were determined in sera collected during a hepatitis outbreak in Pakistan. HEV infection was detected serologically in 122 patients. IgM anti-HEV was detected in specimens collected up to 2 weeks before and 5-7 weeks after hospitalization in 91% and 100%, respectively, of 122 HEV-infected patients. IgG followed a similar pattern. Peak antibody titers appeared 2-4 weeks after hospitalization. At 20 months after hospitalization, IgM anti-HEV was not detected in any of 33 patients; IgG was found in all. Ige anti-HEV appeared to be protective in contacts of patients. This study confirms HEV as the cause of the outbreak, quantifies IgM and IgG anti-HEV responses, provides evidence that Ige anti-HEV protects against hepatitis E, and demonstrates that Ige anti-HEV persists, but at diminished titer, after infection. Hepatitis E in young adults is the result of primary infection with HEV and, if reinfection occurs, it does not commonly cause serious illness. C1 NIAID,INFECT DIS LAB,BETHESDA,MD 20892. PAKISTAN US LAB SEROEPIDEMIOL,RAWALPINDI,PAKISTAN. WALTER REED ARMY INST RES,DEPT VIRUS DIS,WASHINGTON,DC. RP BRYAN, JP (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT PREVENT MED & BIOMETR,BETHESDA,MD 20814, USA. RI Ticehurst, John/I-7532-2012 NR 20 TC 111 Z9 114 U1 0 U2 3 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD SEP PY 1994 VL 170 IS 3 BP 517 EP 521 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA PE265 UT WOS:A1994PE26500003 PM 8077708 ER PT J AU LIN, HJ MYERS, LE YENLIEBERMAN, B HOLLINGER, FB HENRARD, D HOOPER, CJ KOKKA, R KWOK, S RASHEED, S VAHEY, M WINTERS, MA MCQUAY, LJ NARA, PL REICHELDERFER, P COOMBS, RW JACKSON, JB AF LIN, HJ MYERS, LE YENLIEBERMAN, B HOLLINGER, FB HENRARD, D HOOPER, CJ KOKKA, R KWOK, S RASHEED, S VAHEY, M WINTERS, MA MCQUAY, LJ NARA, PL REICHELDERFER, P COOMBS, RW JACKSON, JB TI MULTICENTER EVALUATION OF QUANTIFICATION METHODS FOR PLASMA HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 RNA SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID POLYMERASE CHAIN-REACTION; HIV-INFECTED INDIVIDUALS; CLINICAL-TRIALS GROUP; REVERSE-TRANSCRIPTASE; COMBINATION THERAPY; VIREMIA; ZIDOVUDINE; ANTIGEN; VIRIONS; ASSAY AB Six procedures for quantifying plasma human immunodeficiency virus type 1 (HIV-1) RNA were evaluated by nine laboratories. The procedures differed in their sample volume and preparation of samples and methods of amplification and detection. Coded samples in a 10-fold dilution series of HIV-1-spiked plasma were correctly ranked by all six procedures. Subsequently, coded duplicate plasma samples from 16 HIV-1-infected patients were tested using a common set of standards. Several HIV-1 RNA procedures were sufficiently reproducible so that an empiric 4-fold change could be viewed as significant. HIV-1 RNA levels in the patients (up to 370,000 RNA copies/mL) correlated with proviral HIV-1 DNA and were inversely correlated with CD4 cell counts; HIV-1 RNA assays were more sensitive than plasma viremia, standard p24 antigen, or immune complex-dissociated p24 antigen assays. This study demonstrated that several HIV-1 RNA quantitative assays are ready for use in clinical trials. C1 CASE WESTERN RESERVE UNIV,INST PATHOL,CLEVELAND,OH 44106. BAYLOR COLL MED,DIV MOLEC VIROL,HOUSTON,TX 77030. RES TRIANGLE INST,RES TRIANGLE PK,NC 27709. UNIV CLEVELAND HOSP,CLEVELAND CLIN FDN,DEPT PATHOL,CLEVELAND,OH 44106. ABBOTT LABS,ABBOTT PK,IL 60064. UNIV WASHINGTON,RETROVIRUS LAB,SEATTLE,WA 98195. CHIRON CORP,EMERYVILLE,CA 94608. ROCHE MOLEC SYST,ALAMEDA,CA. UNIV SO CALIF,SCH MED,VIRAL ONCOL & AIDS RES LAB,LOS ANGELES,CA. STANFORD UNIV,SCH MED,CTR AIDS RES,PALO ALTO,CA 94304. WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD. NIAID,DIV AIDS,ROCKVILLE,MD. NCI,TUMOR CELL BIOL LAB,VIRUS BIOL SECT,FREDERICK,MD 21701. FU NIAID NIH HHS [AI-25879, AI-82517, AI-27664] NR 29 TC 141 Z9 142 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD SEP PY 1994 VL 170 IS 3 BP 553 EP 562 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA PE265 UT WOS:A1994PE26500008 PM 7915748 ER PT J AU BHATTACHARJEE, AK OPAL, SM PALARDY, JE DRABICK, JJ COLLINS, H TAYLOR, R COTTON, A CROSS, AS AF BHATTACHARJEE, AK OPAL, SM PALARDY, JE DRABICK, JJ COLLINS, H TAYLOR, R COTTON, A CROSS, AS TI AFFINITY-PURIFIED ESCHERICHIA-COLI J5 LIPOPOLYSACCHARIDE-SPECIFIC IGG PROTECTS NEUTROPENIC RATS AGAINST GRAM-NEGATIVE BACTERIAL SEPSIS SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID LINKED IMMUNOSORBENT-ASSAY; TUMOR-NECROSIS-FACTOR; PSEUDOMONAS-AERUGINOSA; ANTIENDOTOXIN ANTIBODIES; SALMONELLA-MINNESOTA; MONOCLONAL-ANTIBODY; LETHAL INFECTION; ENDOTOXIN CORE; ROUGH MUTANTS; RE-EVALUATION AB Antibodies were raised in rabbits by immunization with the heat-killed J5 mutant of Escherichia coli O111 (Re chemotype). Serum antibodies were separated into purified IgG and IgM by sequential affinity chromatography on protein G-Sepharose and anti-rabbit IgG-Sepharose columns. J5 lipopolysaccharide (LPS)-specific IgG was prepared by affinity chromatography of purified Ige on a J5 LPS-EAH Sepharose 4B affinity column. Purified IgM, IgG, and J5 LPS-specific IgG protected neutropenic rats against lethal challenge with Pseudomonas aeruginosa 12:4:4 (Fisher Devlin immunotype 6). Nine of 16 rats treated with the IgM fraction were protected (P < .001). Thirteen of 20 rats treated with the purified IgG and 6 of 8 treated with J5 LPS-specific IBG were protected compared with none of 25 treated with IgG made from the preimmune serum of the same rabbit (P < .001). These results demonstrate that purified J5 LPS-specific IgG protects against the lethal consequences of gram-negative bacteremia. C1 BROWN UNIV,SCH MED,INFECT DIS SECT,PROVIDENCE,RI 02912. RP BHATTACHARJEE, AK (reprint author), WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307, USA. NR 40 TC 33 Z9 34 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD SEP PY 1994 VL 170 IS 3 BP 622 EP 629 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA PE265 UT WOS:A1994PE26500018 PM 8077720 ER PT J AU SLINEY, DH DENNIS, JE AF SLINEY, DH DENNIS, JE TI SAFETY CONCERNS ABOUT LASER POINTERS SO JOURNAL OF LASER APPLICATIONS LA English DT Article DE LASER SAFETY STANDARDS; DIODE-LASER POINTERS AB In the past two years considerable concerns have been expressed about the safety of Class 3A laser pointers. The concern has been that Class 3A diode-laser pointers have replaced the safer helium-neon (He-Ne) Class 2 laser pointers. Hundreds of thousands of small He-Ne visible-wavelength lasers have been traditionally used for alignment and pointing, laser demonstrations and laser displays in science, education and industry, but can the diode laser be as safe and effective? Not infrequently, some people associate ''lasers'' with Buck Rogers and ''Star Wars'', and are concerned whether their use in public is safe. This safety issue is raised and the risks of viewing small lasers are compared with viewing the sun or bright spotlights. It is shown that He-Ne lasers through Class 3a (up to 5 mW power) are not a significant eye hazard; however, Class 3A diode lasers may not elicit a strong ''aversion response'' in some individuals, and greater precautions may be necessary than with He-Ne lasers of the same power. C1 US FDA,CTR DEVICES & RADIOL HLTH,OFF COMPLIANCE & SURVEILLANCE,ROCKVILLE,MD 20857. RP SLINEY, DH (reprint author), USA,ENVIRONM HYG AGCY,DIV LASER MICROWAVE,ABERDEEN PROVING GROUND,MD 21010, USA. NR 5 TC 14 Z9 14 U1 0 U2 4 PU LASER INST AMER PI ORLANDO PA 12424 RESEARCH PARKWAY SUITE 125, ORLANDO, FL 32826 SN 1042-346X J9 J LASER APPL JI J. Laser Appl. PD SEP PY 1994 VL 6 IS 3 BP 159 EP 164 PG 6 WC Materials Science, Multidisciplinary; Optics; Physics, Applied SC Materials Science; Optics; Physics GA PJ654 UT WOS:A1994PJ65400007 ER PT J AU FAN, SX TURPIN, JA ARONOVITZ, JR MELTZER, MS AF FAN, SX TURPIN, JA ARONOVITZ, JR MELTZER, MS TI INTERFERON-GAMMA PROTECTS PRIMARY MONOCYTES AGAINST INFECTION WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 SO JOURNAL OF LEUKOCYTE BIOLOGY LA English DT Article DE MONOCYTES; INTERFERON-GAMMA; HIV-1 ID COLONY-STIMULATING FACTOR; III REPLICATION INVITRO; NECROSIS-FACTOR-ALPHA; T-CELLS; HTLV-III; HIV REPLICATION; MONONUCLEAR PHAGOCYTES; REVERSE-TRANSCRIPTASE; TREATED MONOCYTES; CELLULAR PROTEINS AB Monocytes treated with 500 IU/ml human recombinant interferon-gamma (rIFN-gamma) 1 day before and continuously after human immunodeficiency virus (HIV) infection showed no evidence of virus replication 7 days after addition of the viral inoculum. There was no HIV-associated cytopathic effect, no reverse transcriptase (RT) activity or p24 detected in culture fluids, and no HIV RNA or DNA in cell lysates. Furthermore, no evidence of HIV infection was evident in replicate cultures in which all IFN-gamma was removed at 7 days and the cells were cultured for an additional 3 weeks without IFN-gamma The 50% inhibitory dose for reduction of maximum RT activity in HIV-infected monocyte cultures was about 1 IU/ml IFN-gamma. No increase in HIV replication was evident in monocytes treated with IFN-gamma at any concentration (0 to 5000 IU/ml) or at any time (7 days before to 10 days after HIV infection). In side-by-side experiments with identical monocytes and HIV-1 stock, rIFN-gamma was 10 to 20 times more effective than rIFN-alpha 2b for induction of antiviral activity. With both interferons, significant antiviral activity was evident with monocytes treated 1 day before, at the time of, or up to 3 days after infection. At 7 to 10 days after infection (a time at which less than 20% of total cells were infected with HIV) addition of even high concentrations of IFN-alpha or IFN-gamma had no effect on virus replication. These data suggest that the principal action of IFN-alpha and IFN-gamma was directed against the fluid-phase virus. Cell-cell spread of infection within the HIV-infected monocyte culture and extent of virus replication in HIV-infected cells were not affected by interferon treatment. C1 CATHOLIC UNIV AMER,WASHINGTON,DC 20064. WALTER REED ARMY INST RES,DEPT CELLULAR IMMUNOL,WASHINGTON,DC. NR 54 TC 25 Z9 25 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0741-5400 J9 J LEUKOCYTE BIOL JI J. Leukoc. Biol. PD SEP PY 1994 VL 56 IS 3 BP 362 EP 368 PG 7 WC Cell Biology; Hematology; Immunology SC Cell Biology; Hematology; Immunology GA PF341 UT WOS:A1994PF34100023 PM 8083609 ER PT J AU KELLY, DJ DASCH, GA CHAN, TC HO, TM AF KELLY, DJ DASCH, GA CHAN, TC HO, TM TI DETECTION AND CHARACTERIZATION OF RICKETTSIA-TSUTSUGAMUSHI (RICKETTSIALES, RICKETTSIACEAE) IN INFECTED LEPTOTROMBIDIUM (LEPTOTROMBIDIUM) FLETCHERI CHIGGERS (ACARI, TROMBICULIDAE) WITH THE POLYMERASE CHAIN-REACTION SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE RICKETTSIA-TSUTSUGAMUSHI; LEPTOTROMBIDIUM-FLETCHERI; POLYMERASE CHAIN REACTION ID MOLECULAR-CLONING; SEQUENCE-ANALYSIS; SCRUB TYPHUS; ANTIGEN; GENE AB We developed a method for detecting and characterizing the DNA of Rickettsia tsutsugamushi in chiggers (larval trombiculid mites) by polymerase chain reaction (PCR). Three procedures for extracting DNA from frozen chiggers were compared by evaluating the yield of PCR amplicand obtained with nine oligonucleotide primer pairs derived from the rickettsial 22 kD, 47 kD, groESL, 56 kD, and 110 kD antigen genes. Although extracts and primer pairs differed in amplification efficiency, R. tsutsugamushi DNA was successfully detected in extracts of colonized infected Leptotrombidium (Leptotrombidium) fletcheri (Wormersley & Heaslip) chiggers and in uninfected chigger extracts seeded with known amounts of Karp-strain rickettsiae. The 22 kD gene restriction fragment length polymorphisms (RFLP) observed in PCR amplicands from five rickettsial isolates obtained from the infected chigger colony over a 26-yr period were identical to those of PCR amplicands derived directly from infected chiggers taken from the same colony. This suggests that stable transmission of R. tsutsugamushi occurs in mites (62 generations), and isolates encompass the full genetic heterogeneity found in the chigger. PCR/RFLP analysis is an important new tool for investigating the complex epidemiology of scrub typhus rickettsiae in their mite vectors. C1 USN,MED RES INST,VIRAL & RICKETTSIAL DIS PROGRAM,BETHESDA,MD 20889. WALTER REED ARMY MED CTR,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. INST MED RES,DIV ACAROL,50588 KUALA LUMPUR,MALAYSIA. NR 25 TC 24 Z9 26 U1 0 U2 0 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD SEP PY 1994 VL 31 IS 5 BP 691 EP 699 PG 9 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA PF625 UT WOS:A1994PF62500009 PM 7966172 ER PT J AU SMITS, JG BALLATO, A AF SMITS, JG BALLATO, A TI DYNAMIC ADMITTANCE MATRIX OF PIEZOELECTRIC CANTILEVER BIMORPHS SO JOURNAL OF MICROELECTROMECHANICAL SYSTEMS LA English DT Article ID PI-FET ACCELEROMETER; CONSTITUENT EQUATIONS AB The matrix that relates the harmonically varying driving parameters: a moment M at the tip, a force F at the tip, a uniformly applied body force p and voltage V to their response parameters: the tip rotation alpha, the tip deflection delta, the volumetric displacement V and the electrode charge Q, have been determined, The electrical element of this matrix is the (4,4) element, which is the electrical capacitance, hence we call this the dynamic admittance matrix, It is a four by four symmetric matrix having a purely electrical part, a purely elastic part and a mixed (piezoelectric) part, A common factor in nearly all elements describes the resonance frequencies that are to be expected. [88] C1 USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. RP SMITS, JG (reprint author), BOSTON UNIV,DEPT ELECT COMP & SYST ENGN,BOSTON,MA 02215, USA. NR 19 TC 82 Z9 95 U1 1 U2 8 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 1057-7157 J9 J MICROELECTROMECH S JI J. Microelectromech. Syst. PD SEP PY 1994 VL 3 IS 3 BP 105 EP 112 DI 10.1109/84.311560 PG 8 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA RM176 UT WOS:A1994RM17600003 ER PT J AU RITCHIE, B BOWDEN, CM AF RITCHIE, B BOWDEN, CM TI QUANTUM-CLASSICAL ELECTRODYNAMIC FIELD CORRESPONDENCE IN QUANTUM OPTICS SO JOURNAL OF MODERN OPTICS LA English DT Article ID RADIATION REACTION AB It is shown that causality is not violated in the classical electro-dynamic description of radiation reaction provided a physically appropriate form of the classical field is used. As a consequence the classical and quantum electrodynamic theories of a bound electron have a similar mathematical structure. C1 USA,MISSILE COMMAND,CTR RES DEV & ENGN,RES DIRECTORATE,REDSTONE ARSENAL,AL 35898. RP RITCHIE, B (reprint author), LAWRENCE LIVERMORE NATL LAB,POB 808,LIVERMORE,CA 94550, USA. NR 11 TC 1 Z9 1 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI LONDON PA ONE GUNDPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 0950-0340 J9 J MOD OPTIC JI J. Mod. Opt. PD SEP PY 1994 VL 41 IS 9 BP 1739 EP 1745 DI 10.1080/09500349414551691 PG 7 WC Optics SC Optics GA PM105 UT WOS:A1994PM10500005 ER PT J AU LEW, D MARINO, AA STARTZELL, JM KELLER, JC AF LEW, D MARINO, AA STARTZELL, JM KELLER, JC TI A COMPARATIVE-STUDY OF OSSEOINTEGRATION OF TITANIUM IMPLANTS IN CORTICOCANCELLOUS BLOCK AND CORTICOCANCELLOUS CHIP GRAFTS IN CANINE ILIUM SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article ID BONE-GRAFTS; DENTAL IMPLANTS C1 LOUISIANA STATE UNIV,DEPT ORTHOPED SURG,SHREVEPORT,LA 71105. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. UNIV IOWA,DOWS INST DENT RES,IOWA CITY,IA 52242. RP LEW, D (reprint author), UNIV IOWA HOSP & CLIN,DEPT ORAL & MAXILLOFACIAL SURG,200 HAWKINS DR E202GH,IOWA CITY,IA 52242, USA. NR 16 TC 25 Z9 25 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD SEP PY 1994 VL 52 IS 9 BP 952 EP 958 PG 7 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA PE357 UT WOS:A1994PE35700016 PM 8064459 ER PT J AU BASQUILL, PJ STEFLIK, DE BRENNAN, WA HORNER, J VANDYKE, TE AF BASQUILL, PJ STEFLIK, DE BRENNAN, WA HORNER, J VANDYKE, TE TI EVALUATION OF THE EFFECTS OF DIAGNOSTIC RADIATION ON TITANIUM DENTAL IMPLANT OSSEOINTEGRATION IN THE MICROPIG SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE DENTAL IMPLANTS; OSSEOINTEGRATION; RADIATION EFFECTS; RADIATION INJURIES ID MINIATURE SWINE; ORAL IMPLANTS AB THE EFFECT THAT DIAGNOSTIC RADIATION may have on peri-implant supporting alveolar tissues is not well understood. Fifty-four (54) titanium dental implants were inserted into the posterior mandible of nine micropigs. At implant placement surgery, 18 implants were exposed to either 2 (diagnostic) or 10 (excessive) doses of diagnostic radiation; the remaining 36 implants served as controls. Fourteen weeks after implant placement, standardized clinical radiographs were taken, pigs were euthanized, and implants with supporting alveolar tissues were prepared and examined by light and scanning electron microscopy (SEM). Ninety-seven sections were evaluated by SEM for morphometric and morphologic analyses. The mean percent of implant length in contact with bone was 47% for the controls and 53% for the implants receiving radiation. Five implants were lost during the initial healing phase and four implants were clinically mobile at time of euthanasia, giving a success rate of 83% (45/54). Correlative light microscopy of periimplant supporting tissues revealed no distinct differences between the microvasculature of controls versus implants exposed to radiation. Standardized clinical radiographs revealed crestal saucerization in both control and radiated implants. This study revealed no statistically significant difference for the percent of implant length in contact with alveolar bone for controls or implants exposed to 2 or 10 doses of diagnostic radiation at implant placement time. C1 USA,FT SILL,OK. MED COLL GEORGIA,AUGUSTA,GA 30912. EASTMAN DENT CTR,ROCHESTER,NY 14620. EISENHOWER ARMY MED CTR,FT GORDON,GA. NR 23 TC 9 Z9 10 U1 0 U2 0 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD SEP PY 1994 VL 65 IS 9 BP 872 EP 880 PG 9 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA PG784 UT WOS:A1994PG78400011 PM 7990025 ER PT J AU CARTER, DR DONNELLY, JC AF CARTER, DR DONNELLY, JC TI THE EFFECT OF DOWEL LUBRICATION ON RETENTION OF RESIN-CEMENTED DOWELS SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID POSTS; REMOVAL; RETREATMENT; COMPOSITE AB Threaded dowels were cemented into prepared canals of extracted human teeth by use of unfilled Bis-GMA resin cement. One half the dowels were lubricated before cementation, unscrewed partially, and reseated to original length after cement had set, to assure retrievability. There was no significant difference in mean tensile force required to dislodge the dowels cemented with or without prior lubrication. Lubrication of dowels makes them predictably and easily retrievable with no short-term effect on tensile strength of the cemented lubricated dowels. Long-term effects of the lubricant on the resin are unknown. C1 USA,DENT ACTIV,FT HOOD,TX. NR 15 TC 2 Z9 2 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD SEP PY 1994 VL 72 IS 3 BP 255 EP 258 DI 10.1016/0022-3913(94)90338-7 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA PD992 UT WOS:A1994PD99200007 PM 7965898 ER PT J AU GEBHART, DL JOHNSON, HB MAYEUX, HS POLLEY, HW AF GEBHART, DL JOHNSON, HB MAYEUX, HS POLLEY, HW TI THE CRP INCREASES SOIL ORGANIC-CARBON SO JOURNAL OF SOIL AND WATER CONSERVATION LA English DT Article ID VEGETATIVE COVER; MATTER; CULTIVATION; GRASSLAND; DYNAMICS; TILLAGE; STORAGE AB The land use change from cropland to perennial grass cover associated with the Conservation Reserve Program (CRP) may sequester atmospheric CO2 back into the soil carbon pool, thereby changing formerly cultivated soils from sources to sinks for atmospheric carbon. To evaluate the effect of CRP on soil organic carbon (SOC) levels, samples.from adjacent cropland, native pasture. and five year old CRP sites in Texas, Kansas, and Nebraska were analyzed. Across all locations, SOC levels for cropland, CRP, and native pasture were 59.2, 65.1, and 90.8 metric tons C ha-1 in the surface 300 cm, respectively. CRP lands gained an average of 1.1 tons C ha-1 yr-1 suggesting that the 17 million hectares of land enrolled in CRP may have the potential to sequester about 45% of the 38.1 million tons of carbon released annually into the atmosphere from U.S. agriculture. These findings illustrate that agricultural CO2 emissions may be effectively controlled through changes in land use and management systems. C1 USDA ARS,GRASSLAND SOIL & WATER RES LAB,TEMPLE,TX 76502. RP GEBHART, DL (reprint author), USA,CERI,ENB,POB 9005,CHAMPAIGN,IL 61826, USA. NR 28 TC 212 Z9 228 U1 4 U2 32 PU SOIL WATER CONSERVATION SOC PI ANKENY PA 7515 N E ANKENY RD, ANKENY, IA 50021-9764 SN 0022-4561 J9 J SOIL WATER CONSERV JI J. Soil Water Conserv. PD SEP-OCT PY 1994 VL 49 IS 5 BP 488 EP 492 PG 5 WC Ecology; Soil Science; Water Resources SC Environmental Sciences & Ecology; Agriculture; Water Resources GA PJ997 UT WOS:A1994PJ99700014 ER PT J AU MILL, JD ONEIL, RR PRICE, S ROMICK, GJ UY, OM GAPOSCHKIN, EM LIGHT, GC MOORE, WW MURDOCK, TL STAIR, AT AF MILL, JD ONEIL, RR PRICE, S ROMICK, GJ UY, OM GAPOSCHKIN, EM LIGHT, GC MOORE, WW MURDOCK, TL STAIR, AT TI MIDCOURSE SPACE EXPERIMENT - INTRODUCTION TO THE SPACECRAFT, INSTRUMENTS, AND SCIENTIFIC OBJECTIVES SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article AB A suite of state-of-the-art sensors, including a cryogenic infrared scanning radiometer and Fourier-transform spectrometer, several visible and ultraviolet imagers and spectrographic imagers, and a set of contamination instruments, are at present being integrated with a highly capable spacecraft for a planned 1994 launch into a polar orbit. The optical sensors cover the spectrum from the far ultraviolet through the longwave infrared (110 nm to 28 mu m). The Midcourse Space Experiment (MSX) satellite, funded and managed by the Ballistic Missile Defense Organization, will be a long-duration, observatory-style measurement platform that will collect several terabytes of high-quality data on earth, earthlimb, and celestial backgrounds, ICBM-style targets, and resident space objects. While the principal focus of MSX is to collect phenomenology data in support of ballistic missile defense objectives, it will also be capable of collecting cell-calibrated data in support of a variety of civilian science objectives in earth and atmospheric remote sensing and astronomy. This paper reviews the mission objectives, describes the spacecraft and the instrumentation, and discusses the planned observations. It also outlines an innovative approach to reducing, analyzing, and archiving the large database that will result from several years of data collection supporting a variety of scientific objectives. C1 USAF,PHILLIPS LAB,DIV OPT ENVIRONM,SIMULAT BRANCH,BEDFORD,MA 01731. JOHNS HOPKINS UNIV,APPL PHYS LAB,GEOSPACE REMOTE SENSING GRP,LAUREL,MD 20723. USAF,PHILLIPS LAB,DIV OPT ENVIRONM,BACKGROUNDS BRANCH,BEDFORD,MA 01731. JOHNS HOPKINS UNIV,DEPT TECH SERV,MAT LAB,APPL PHYS LAB,LAUREL,MD 20723. MIT,LINCOLN LAB,DIV AEROSP,LEXINGTON,MA 02173. AEROSP CORP,DIV SURVEILLANCE & DEF INTEGRAT,LOS ANGELES,CA 90009. USA,SPACE & STRATEG DEF COMMAND,DIV OPT SENSORS,SENSOR COMPONENTS TECHNOL BRANCH,HUNTSVILLE,AL 35807. GEN RES CORP,SCI & PHENOMENOL OPERAT,DANVERS,MA 01923. VISIDYNE,BURLINGTON,MA 01803. RP MILL, JD (reprint author), ENVIRONM RES INST MICHIGAN,DIV TECH OPERAT,WASHINGTON OFF,ARLINGTON,VA 22209, USA. NR 12 TC 146 Z9 148 U1 0 U2 5 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0022-4650 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD SEP-OCT PY 1994 VL 31 IS 5 BP 900 EP 907 DI 10.2514/3.55673 PG 8 WC Engineering, Aerospace SC Engineering GA QA684 UT WOS:A1994QA68400028 ER PT J AU CAROME, MA KANG, YH BOHEN, EM NICHOLSON, DE CARR, FE YUAN, CM AF CAROME, MA KANG, YH BOHEN, EM NICHOLSON, DE CARR, FE YUAN, CM TI THE DISTRIBUTION OF RADIOLABELED PHOSPHOROTHIOATE OLIGONUCLEOTIDES (S-ODNS) WITHIN THE RAT-KIDNEY FOLLOWING INTRAVENOUS ADMINISTRATION SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,NEPHROL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,ENDOCRINE SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. USN,MED RES INST,DIV PATHOBIOL,BETHESDA,MD 20814. NR 0 TC 1 Z9 1 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD SEP PY 1994 VL 5 IS 3 BP 618 EP 618 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA PG771 UT WOS:A1994PG77101489 ER PT J AU SALZBERG, DJ CAROME, MA MUSIO, F YUAN, CM AF SALZBERG, DJ CAROME, MA MUSIO, F YUAN, CM TI INDUCTION OF THE HEAT-SHOCK RESPONSE REDUCES CISPLATINUM TOXICITY IN CULTURED RENAL EPITHELIAL-CELLS SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,NEPHROL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD SEP PY 1994 VL 5 IS 3 BP 930 EP 930 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA PG771 UT WOS:A1994PG77102732 ER PT J AU YUAN, CM MUSIO, F BOHEN, EM CAROME, MA AF YUAN, CM MUSIO, F BOHEN, EM CAROME, MA TI THE PROTECTIVE EFFECT OF HEAT-SHOCK (HS) ON SUBSEQUENT CYCLOSPORINE-A (CYA) TOXICITY IN RENAL EPITHELIAL-CELLS IN-VITRO DECLINES CONCURRENTLY WITH DECREASING HSP-70 LEVELS SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,NEPHROL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD SEP PY 1994 VL 5 IS 3 BP 934 EP 934 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA PG771 UT WOS:A1994PG77102746 ER PT J AU YUAN, CM POPHAM, SG MUSIO, F SALZBERG, DJ BOHEN, EM CAROME, MA AF YUAN, CM POPHAM, SG MUSIO, F SALZBERG, DJ BOHEN, EM CAROME, MA TI MANNITOL PROTECTS LLC-PK1 CELLS FROM CYCLOSPORINE-A (CYA) TOXICITY WITHOUT INDUCTION OF HEAT-SHOCK PROTEIN 70 'HSP 70) GENE EXPRESSION SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,NEPHROL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD SEP PY 1994 VL 5 IS 3 BP 934 EP 934 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA PG771 UT WOS:A1994PG77102745 ER PT J AU MONTGOMERY, SR GALLAGHER, MP SALAMO, GJ SHARP, EJ WOOD, GL NEUROAONKAR, RR AF MONTGOMERY, SR GALLAGHER, MP SALAMO, GJ SHARP, EJ WOOD, GL NEUROAONKAR, RR TI COOPERATIVE PHOTOREFRACTIVE BEAM FANNING IN BASRKNANB5O(15) SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS LA English DT Article ID SCATTERING; BATIO3 AB A multiline laser beam incident upon a BaSrKNaNb5O15 crystal causes rings to form in the beam fan by means of cooperative photorefractive fanning between the different wavelengths. We examine the novel case in which the input beam consists of two lines from an argon-ion laser with independently controlled linear polarizations as well as the single-line case with equal amounts of ordinary and extraordinary light. We compute the expected rings in each case, taking full account of the crystal birefringence, and compare them with the experimental data. Applications of the rings to crystallography and cryptology are presented. C1 UNIV ARKANSAS,DEPT PHYS,FAYETTEVILLE,AR 72701. USA,FT BELVOIR,VA 22060. ROCKWELL INT SCI CTR,THOUSAND OAKS,CA 91360. RP MONTGOMERY, SR (reprint author), USN ACAD,DEPT PHYS,ANNAPOLIS,MD 21402, USA. NR 9 TC 4 Z9 4 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0740-3224 J9 J OPT SOC AM B JI J. Opt. Soc. Am. B-Opt. Phys. PD SEP PY 1994 VL 11 IS 9 BP 1694 EP 1699 DI 10.1364/JOSAB.11.001694 PG 6 WC Optics SC Optics GA PE853 UT WOS:A1994PE85300023 ER PT J AU UZARSKI, D MCNEIL, S AF UZARSKI, D MCNEIL, S TI TECHNOLOGIES FOR PLANNING RAILROAD TRACK MAINTENANCE AND RENEWAL SO JOURNAL OF TRANSPORTATION ENGINEERING-ASCE LA English DT Article AB Rail continues to be an important transportation mode. Like other transportation infrastructure, maintenance and replacement are critical to ensure safe, efficient operation. Research and development of technologies for condition-data collection and computer-based decision-support systems are not widely reported in the literature due to the nature of the industry. This paper presents an overview of technologies for railroad track-condition assessment and decision-support systems for track maintenance and renewal. Track inspection methods range from visual inspection to the use of sensors and sophisticated measuring systems for the identification of corrugation, measurement of track geometry, measurement of rail wear, and location of internal rail flaws. The data produced by these systems may be integrated into a track-quality index, or a component index, and aggregated by segment. These data are then used for safety evaluations, work planning, and strategic planning of repair and replacement. Decision-support systems attempt to move maintenance and replacement decision making from an art to a science. They are widely used by the larger railroads. A variety of systems and issues are briefly described. RP UZARSKI, D (reprint author), USA,CONSTR ENGN RES LAB,CHAMPAIGN,IL 61820, USA. NR 0 TC 9 Z9 9 U1 1 U2 5 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-947X J9 J TRANSP ENG-ASCE JI J. Transp. Eng.-ASCE PD SEP-OCT PY 1994 VL 120 IS 5 BP 807 EP 820 DI 10.1061/(ASCE)0733-947X(1994)120:5(807) PG 14 WC Engineering, Civil; Transportation Science & Technology SC Engineering; Transportation GA PC790 UT WOS:A1994PC79000008 ER PT J AU SCHENKMAN, NS FERNANDEZ, EB WIND, G IRBY, P AF SCHENKMAN, NS FERNANDEZ, EB WIND, G IRBY, P TI INVERTED Y-DUPLICATION OF THE URETER ASSOCIATED WITH A DISTAL LIMB ECTOPIC TO THE SEMINAL-VESICLE SO JOURNAL OF UROLOGY LA English DT Note DE URINARY CALCULI, KIDNEY, URETER, SEMINAL VESICLES, OLIGOSPERMIA AB Inverted Y duplication of the ureter is a rare anomaly. We report on a 24-year-old man who presented with urolithiasis and azoospermia in a solitary functioning kidney with an inverted Y ureteral duplication. To our knowledge our case represents the first documentation of ectopic emptying of 1 limb of the inverted Y ureter into the seminal vesicle. The embryology and management of this complex case are discussed. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. RP SCHENKMAN, NS (reprint author), WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307, USA. NR 8 TC 3 Z9 3 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD SEP PY 1994 VL 152 IS 3 BP 946 EP 947 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA PB123 UT WOS:A1994PB12300039 PM 8051762 ER PT J AU HEIDENBERG, HB MOUL, JW MOSTOFI, FK MCLEOD, DG AF HEIDENBERG, HB MOUL, JW MOSTOFI, FK MCLEOD, DG TI CLINICALLY DETECTED CARCINOMA OF THE PROSTATE TREATED BY RADICAL PROSTATECTOMY IN A 29-YEAR-OLD MAN SO JOURNAL OF UROLOGY LA English DT Note DE ADENOCARCINOMA, PROSTATECTOMY, PROSTATE ID ADENOCARCINOMA AB Prostate cancer is rare in young adults and when clinically detected it has been invariably locally or distantly advanced, undifferentiated and exhibiting aggressive behavior. To our knowledge no previous report documents clinically detected and localized disease amenable to curative surgery in a young adult. We report on a 29-year-old man with clinically detected, moderately differentiated adenocarcinoma of the prostate who was treated by nerve sparing radical retropubic prostatectomy. The patient was disease-free and morbidity-free 30 months after treatment. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. ARMED FORCES INST PATHOL,DEPT GENITOURIN PATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307. NR 11 TC 6 Z9 7 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD SEP PY 1994 VL 152 IS 3 BP 966 EP 967 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA PB123 UT WOS:A1994PB12300047 PM 8051769 ER PT J AU CARROLL, R LIN, JT DACQUEL, EJ MOSCA, JD BURKE, DS STLOUIS, DC AF CARROLL, R LIN, JT DACQUEL, EJ MOSCA, JD BURKE, DS STLOUIS, DC TI A HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1)-BASED RETROVIRAL VECTOR SYSTEM UTILIZING STABLE HIV-1 PACKAGING CELL-LINES SO JOURNAL OF VIROLOGY LA English DT Note ID CIS-ACTING SEQUENCES; GENE-TRANSFER; PARTICLE FORMATION; MAMMALIAN-CELLS; VIRAL-DNA; HTLV-III; T-CELL; RNA; EXPRESSION; REGION AB We have constructed stable human immunodeficiency virus (HIV) packaging cell lines that when transfected with an HIV-based retroviral vector produce packaged vectors capable of transducing susceptible CD4(+) cells. This HIV-1-based retroviral vector system has the potential for providing targeted delivery and regulated expression of immunogens or antiviral agents in CD4(+) cells. C1 WALTER REED ARMY INST RES,ROCKVILLE,MD 20850. RP CARROLL, R (reprint author), HENRY M JACKSON FDN ADVANCEMENT MIL MED,RES LAB,1600 E GUDE DR,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 NR 33 TC 47 Z9 49 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD SEP PY 1994 VL 68 IS 9 BP 6047 EP 6051 PG 5 WC Virology SC Virology GA PB785 UT WOS:A1994PB78500078 PM 8057479 ER PT J AU MAZION, E YEN, BC AF MAZION, E YEN, BC TI COMPUTATIONAL DISCRETIZATION EFFECT ON RAINFALL-RUNOFF SIMULATION SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT-ASCE LA English DT Article AB Modeling catchment runoff require spatial discretization of the catchment for computation. This study investigates the effect that the size of the computational discretization has on the results of a simulation. Three different types of models (namely, a rational formula model, an Australian nonlinear conceptual model (RORB), and a physical-process-based distributed model (HEC-1) were tested by applying them to a hypothetical catchment. For each model the spatial discretization size for computations was systematically decreased, while all other catchment and model parameters were held constant. It was observed that even for a simple, homogeneous, hypothetical catchment the simulated runoff results are significantly affected by the computational spatial size of the catchment used regardless of the type of model applied to the catchment. C1 UNIV ILLINOIS,DEPT CIVIL ENGN,URBANA,IL 61801. RP MAZION, E (reprint author), USA,CORPS ENGRS,WES,VICKSBURG,MS 39180, USA. NR 10 TC 6 Z9 6 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9496 J9 J WATER RES PL-ASCE JI J. Water Resour. Plan. Manage.-ASCE PD SEP-OCT PY 1994 VL 120 IS 5 BP 715 EP 734 DI 10.1061/(ASCE)0733-9496(1994)120:5(715) PG 20 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA PC802 UT WOS:A1994PC80200008 ER PT J AU ZDZIARSKI, JM MATTIX, M BUSH, RM MONTALI, RJ AF ZDZIARSKI, JM MATTIX, M BUSH, RM MONTALI, RJ TI ZINC TOXICOSIS IN DIVING DUCKS SO JOURNAL OF ZOO AND WILDLIFE MEDICINE LA English DT Note DE TOXICOSIS; TOXICITY; ZINC; PANCREAS; DUCKS; BUCEPHALA-ISLANDICA ID INDUCED HEMOLYTIC-ANEMIA; DOG; INGESTION; PENNIES; TOXICITY; COPPER AB Zinc toxicosis was diagnosed in four species of diving ducks associated with the ingestion of pennies and fence clips containing zinc. Clinical signs included weight loss, depression, anorexia, and posterior paresis. A presumptive diagnosis of zinc toxicosis was made in one Bahama pintail (Anas bahamensis bahamensis) and two redhead ducks (Aythya americana) that had ingested metal fence clips. Diagnosis was based on complete recovery of the ducks after endoscopic removal of the clips, which contained 96% zinc. Assays for zinc and other minerals were performed on four Barrow's goldeneyes (Bucephala islandica) that died and one American merganser (Mergus merganser americanus) survivor. All of the animals had ingested one or two pennies. Two of four goldeneyes, from which serum was available, had elevated zinc concentrations of 12.6 and 13.1 mug/ml (normal range, 1.84-4.65 mug/ml, n = 8); all four goldeneyes had liver zinc concentrations ranging from 242 to 548 mug/g (normal, 35.9 mug/g, wet weight basis, n = 1). The American merganser from which a penny was removed endoscopically from the gizzard had an elevated serum zinc concentration of 16.6 mug/ml. Pertinent pathologic findings in the four goldeneyes included necrotizing ventriculitis. Pennies in various stages of dissolution were present in the ventriculus. The pancreas had degenerative lesions that resulted in acinar atrophy and ductular proliferation. C1 NATL ZOOL PK,DEPT ANIM HLTH,WASHINGTON,DC 20008. BROOKFIELD ZOO,3300 S GOLF RD,BROOKFIELD,IL 60513. WALTER REED ARMY INST RES,DIV PATHOL,WASHINGTON,DC 20307. NR 17 TC 17 Z9 18 U1 0 U2 2 PU AMER ASSOC Z00 VETERINARIANS PI MEDIA PA 6 NORTH PENNELL ROAD, MEDIA, PA 19063 SN 1042-7260 J9 J ZOO WILDLIFE MED JI J. Zoo Wildl. Med. PD SEP PY 1994 VL 25 IS 3 BP 438 EP 445 PG 8 WC Veterinary Sciences SC Veterinary Sciences GA PF358 UT WOS:A1994PF35800012 ER PT J AU BARTH, J AF BARTH, J TI WAL-MART - A HISTORY OF WALTON,SAM RETAIL PHENOMENON - VANCE,SS, SCOTT,RV SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY, USA. NR 1 TC 0 Z9 0 U1 0 U2 3 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD SEP 1 PY 1994 VL 119 IS 14 BP 195 EP 195 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA PE175 UT WOS:A1994PE17500133 ER PT J AU FOOTE, WG AF FOOTE, WG TI THE CHEMICAL DEMILITARIZATION PROGRAM - WILL IT DESTROY THE NATIONS STOCKPILE OF CHEMICAL WEAPONS BY DECEMBER 31, 2004 SO MILITARY LAW REVIEW LA English DT Article ID LIABILITY C1 USA,JUDGE ADVOCATE GEN CORPS,CHARLOTTESVILLE,VA 22903. NR 92 TC 4 Z9 4 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1994 VL 146 BP 1 EP 93 PG 93 WC Law SC Government & Law GA RX349 UT WOS:A1994RX34900001 ER PT J AU DRIBBEN, DA AF DRIBBEN, DA TI DNA STATISTICAL EVIDENCE AND THE CEILING PRINCIPLE - SCIENCE OR SCIENCE-FICTION SO MILITARY LAW REVIEW LA English DT Article ID BIOLOGICAL EVIDENCE SAMPLES; HARDY-WEINBERG EQUILIBRIUM; STATES V YEE; SCIENTIFIC EVIDENCE; UNITED-STATES; POPULATION-GENETICS; FORENSIC USE; NRC REPORT; VNTR LOCI; ADMISSIBILITY C1 USA,JUDGE ADVOCATE GEN CORPS,CHARLOTTESVILLE,VA 22903. NR 98 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1994 VL 146 BP 94 EP 153 PG 60 WC Law SC Government & Law GA RX349 UT WOS:A1994RX34900002 ER PT J AU OROARK, DL AF OROARK, DL TI THE FIRST ANNUAL HUGH-J-CLAUSEN-LEADERSHIP-LECTURE - TRANSFORMATIONAL LEADERSHIP TEACHING THE, JAG ELEPHANT TO DANCE SO MILITARY LAW REVIEW LA English DT Article RP OROARK, DL (reprint author), USA,JUDGE ADVOCATE GEN CORPS,CHARLOTTESVILLE,VA 22903, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1994 VL 146 BP 224 EP 233 PG 10 WC Law SC Government & Law GA RX349 UT WOS:A1994RX34900004 ER PT J AU BALDWIN, GT AF BALDWIN, GT TI STARS IN THEIR COURSES - THE GETTYSBURG CAMPAIGN JUNE JULY 1863 - FOOTE,S SO MILITARY LAW REVIEW LA English DT Book Review C1 USA,SCH JUDGE ADVOCATE GEN,JUDGE ADVOCATE OFFICER GRAD COURSE 43,CHARLOTTESVILLE,VA. USA,JUDGE ADVOCATE GEN SCH,JUDGE ADVOCATE OFFICER GRAD COURSE 43,CHARLOTTESVILLE,VA. RP BALDWIN, GT (reprint author), USA,JUDGE ADVOCATE GEN CORPS,CHARLOTTESVILLE,VA 22903, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1994 VL 146 BP 275 EP 279 PG 5 WC Law SC Government & Law GA RX349 UT WOS:A1994RX34900006 ER PT J AU SHEERAN, E AF SHEERAN, E TI LENINS TOMB - THE LAST DAYS OF THE SOVIET EMPIRE - REMNICK,D SO MILITARY LAW REVIEW LA English DT Book Review C1 USA,JUDGE ADVOCATE GEN SCH,JUDGE ADVOCATE OFFICER GRAD COURSE,CHARLOTTESVILLE,VA 22901. RP SHEERAN, E (reprint author), USA,JUDGE ADVOCATE GEN CORPS,CHARLOTTESVILLE,VA 22903, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1994 VL 146 BP 280 EP 287 PG 8 WC Law SC Government & Law GA RX349 UT WOS:A1994RX34900007 ER PT J AU GIBSON, SS AF GIBSON, SS TI WAR AND ANTIWAR - SURVIVAL AT THE DAWN OF THE 21ST-CENTURY - TOFFLER,A SO MILITARY LAW REVIEW LA English DT Book Review C1 USA,JUDGE ADVOCATE GEN SCH,JUDGE ADVOCATE OFFICER COURSE 43,CHARLOTTESVILLE,VA 22901. RP GIBSON, SS (reprint author), USA,JUDGE ADVOCATE GEN CORPS,CHARLOTTESVILLE,VA 22903, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1994 VL 146 BP 288 EP 290 PG 3 WC Law SC Government & Law GA RX349 UT WOS:A1994RX34900008 ER PT J AU SCHENCK, LM AF SCHENCK, LM TI PRISONERS OF HOPE - EXPLOITING THE POW/MIA MYTH IN AMERICA - KEATING,SK SO MILITARY LAW REVIEW LA English DT Book Review C1 USA,JUDGE ADVOCATE GEN SCH,JUDGE ADVOCATE OFFICER GRAD COURSE 43,CHARLOTTESVILLE,VA 22901. RP SCHENCK, LM (reprint author), USA,JUDGE ADVOCATE GEN SCH,JUDGE ADVOCATE OFFICER GRAD COURSE 43,CHARLOTTESVILLE,VA 22901, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1994 VL 146 BP 291 EP 293 PG 3 WC Law SC Government & Law GA RX349 UT WOS:A1994RX34900009 ER PT J AU WINTHROP, JP AF WINTHROP, JP TI THE LAWS OF WAR - HOWARD,M SO MILITARY LAW REVIEW LA English DT Book Review C1 USA,JUDGE ADVOCATE GEN CORPS,CHARLOTTESVILLE,VA 22903. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1994 VL 146 BP 294 EP 296 PG 3 WC Law SC Government & Law GA RX349 UT WOS:A1994RX34900010 ER PT J AU GADE, WR AF GADE, WR TI CRIME AND PUNISHMENT IN AMERICAN HISTORY - FRIEDMAN,LM SO MILITARY LAW REVIEW LA English DT Book Review C1 USA,JUDGE ADVOCATE GEN SCH,JUDGE ADVOCATE OFFICER GRAD COURSE,CHARLOTTESVILLE,VA 22901. RP GADE, WR (reprint author), USA,JUDGE ADVOCATE GEN CORPS,CHARLOTTESVILLE,VA 22903, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1994 VL 146 BP 297 EP 301 PG 5 WC Law SC Government & Law GA RX349 UT WOS:A1994RX34900011 ER PT J AU CASINELLI, PE REYNOLDS, PC AF CASINELLI, PE REYNOLDS, PC TI ADAPTING THE OHMEDA UPAC DRAW-OVER VAPORIZER FOR USE IN THE MODERN OPERATING-ROOM SO MILITARY MEDICINE LA English DT Article AB Until recently, the use of draw-over anesthesia (DA) for elective cases has been prohibited in American military hospitals. The reasons cited for this have included the possibility of increased patient risk and the delivery of a second level of care. In this article, the authors outline a method of employing DA so as to bring its use up to the safety level of the modern operating room. This allows for the clinical training of those military anesthesia care providers who may find themselves deployed with highly mobile surgical units whose missions demand this technique of anesthesia. RP CASINELLI, PE (reprint author), WOMACK ARMY MED CTR,ANESTHESIA & OPERAT SERV,FT BRAGG,NC 28307, USA. NR 0 TC 4 Z9 4 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 1994 VL 159 IS 9 BP 600 EP 602 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA PQ205 UT WOS:A1994PQ20500004 PM 7800174 ER PT J AU ENGLISH, JC FANOSCHULTZ, J AF ENGLISH, JC FANOSCHULTZ, J TI DERMATOLOGICAL MANIFESTATIONS IN A TROPICAL TRAINING ENVIRONMENT - EMPHASIS FOR THE GENERAL MEDICAL OFFICER SO MILITARY MEDICINE LA English DT Article AB Cutaneous disease in the tropical training environment will be of concern for the medical officer assigned to ensure the health of soldiers participating in training. A review of all ''sick calls'' recorded during deployment to the Jungle Operations Training Center at Fort Sherman, Panama showed that 50% of the medical complaints were dermatologically related. This should emphasize the need for medical officers to have significant dermatologic knowledge and appropriate supplies. RP ENGLISH, JC (reprint author), USA,MED DEPT ACT,DEPT PRIMARY CARE & COMMUNITY MED,650 JOEL DR,FT CAMPBELL,KY 42223, USA. NR 0 TC 5 Z9 5 U1 1 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 1994 VL 159 IS 9 BP 606 EP 608 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA PQ205 UT WOS:A1994PQ20500006 PM 7800176 ER PT J AU FLAHERTY, S ELLISON, R GRISHKIN, BA AF FLAHERTY, S ELLISON, R GRISHKIN, BA TI BILATERAL CHYLOTHORAX FOLLOWING THYMECTOMY - RESOLUTION FOLLOWING UNILATERAL DRAINAGE SO MILITARY MEDICINE LA English DT Note AB Chylothorax is a rare complication of thymectomy. Following thymectomy for myasthenia gravis, our patient developed bilateral chylous pleural effusions. The presence of a ''medi-astinal window'' allowed adequate drainage with a unilateral chest tube. RP FLAHERTY, S (reprint author), EISENHOWER ARMY MED CTR,THORAC SURG SERV,FT GORDON,GA 30905, USA. NR 0 TC 2 Z9 3 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 1994 VL 159 IS 9 BP 627 EP 628 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA PQ205 UT WOS:A1994PQ20500011 PM 7800181 ER PT J AU DETERAWADLEIGH, SD FANNING, TG AF DETERAWADLEIGH, SD FANNING, TG TI PHYLOGENY OF THE STEROID-RECEPTOR SUPERFAMILY SO MOLECULAR PHYLOGENETICS AND EVOLUTION LA English DT Article ID THYROID-HORMONE RECEPTOR; 9-CIS RETINOIC ACID; HUMAN GLUCOCORTICOID RECEPTOR; VITAMIN-D RECEPTOR; A-I GENE; X-RECEPTOR; TRANSCRIPTION FACTOR; RESPONSE ELEMENTS; NUCLEAR RECEPTOR; GENOMIC ORGANIZATION AB The phylogenetic relationships of 56 nuclear hormone receptors from both invertebrates and vertebrates were determined by the parsimony method (PAUP). The consensus tree suggests that the ancestral gene diverged into five major subfamilies, each of which evolved into at least one cluster of related molecules. These subfamilies are represented by: (i) thyroid hormone receptors (TR); (ii) steroid receptors (SR); (iii) retinoic acid receptors (RAR), retinoid X receptors (RXR), and the chicken ovalbumin upstream promoter transcription factor 1 (COUP) group; (ix) peroxisome proliferator-activated receptors (PPAR); and (v) vitamin D receptor (VDR) and knirps (kni) group. Although the neighbor-joining (N-J) method clustered the receptors into a greater number of subfamilies, it was evident that the components of the terminal receptor subgroups were similar to those found in the PAUP tree. These terminal clusters might then represent phylogenetically stable relationships. The positions of some orphan receptors were perturbed when a different algorithm was employed in the analysis. Both PAUP and N-J evolutionary trees showed that the receptors within the subgroups of a major sublineage tend to recognize hormones of very similar structure. This finding suggests that the relative phylogenetic position of orphans to well-characterized receptors might be exploited to predict the type of ligand they would recognize. C1 NIMH, CLIN NEUROGENET BRANCH, BETHESDA, MD 20892 USA. USA, INST PATHOL, DEPT CELLULAR PATHOL, WASHINGTON, DC 20306 USA. NR 100 TC 29 Z9 30 U1 0 U2 6 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1055-7903 EI 1095-9513 J9 MOL PHYLOGENET EVOL JI Mol. Phylogenet. Evol. PD SEP PY 1994 VL 3 IS 3 BP 192 EP 205 DI 10.1006/mpev.1994.1022 PG 14 WC Biochemistry & Molecular Biology; Evolutionary Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Evolutionary Biology; Genetics & Heredity GA PG448 UT WOS:A1994PG44800002 PM 7820284 ER PT J AU GLASS, GE WATSON, AJ LEDUC, JW CHILDS, JE AF GLASS, GE WATSON, AJ LEDUC, JW CHILDS, JE TI DOMESTIC CASES OF HEMORRHAGIC-FEVER WITH RENAL SYNDROME IN THE UNITED-STATES SO NEPHRON LA English DT Article DE HEMORRHAGIC FEVER WITH RENAL SYNDROME; HANTAVIRUS; CHRONIC RENAL DISEASE; HYPERTENSIVE RENAL DISEASE ID HANTAAN VIRUS; HANTAVIRUS; INFECTION; ANTIBODY; DISEASE AB Although serologic studies have identified hantaviral infection in the United States, acute disease has not been recognized. This study describes 3 cases of domestically acquired hemorrhagic fever with renal syndrome (HFRS) in the United States. Infection was due to a local strain of Seoul virus (Baltimore rat virus). A review of the clinical features indicated a mild illness characterized by nausea, vomiting, renal and liver failure similar to HFRS described elsewhere for rat-borne viruses. Follow-up of 2 patients identified persitent hypertension and renal disease providing further evidence of an association between past hantaviral infection and hypertensive renal disease. C1 JOHNS HOPKINS UNIV,SCH MED,DIV NEPHROL,BALTIMORE,MD. USA,MED RES INST INFECT DIS,DEPT EPIDEMIOL,FREDERICK,MD. RP GLASS, GE (reprint author), JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT IMMUNOL & INFECT DIS,615 N WOLFE ST,BALTIMORE,MD 21205, USA. RI Childs, James/B-4002-2012 NR 18 TC 58 Z9 59 U1 0 U2 3 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0028-2766 J9 NEPHRON JI Nephron PD SEP PY 1994 VL 68 IS 1 BP 48 EP 51 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA PD898 UT WOS:A1994PD89800008 PM 7991040 ER PT J AU DOYLE, M JABBARI, B AF DOYLE, M JABBARI, B TI HYPERTROPHIC BRANCHIAL MYOPATHY TREATED WITH BOTULINUM TOXIN TYPE-A SO NEUROLOGY LA English DT Note ID MUSCLE HYPERTROPHY C1 WALTER REED ARMY MED CTR,DEPT NEUROL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT NEUROL,BETHESDA,MD 20814. RP DOYLE, M (reprint author), WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20307, USA. NR 7 TC 8 Z9 8 U1 0 U2 0 PU LITTLE BROWN CO PI BOSTON PA 34 BEACON STREET, BOSTON, MA 02108-1493 SN 0028-3878 J9 NEUROLOGY JI Neurology PD SEP PY 1994 VL 44 IS 9 BP 1765 EP 1766 PG 2 WC Clinical Neurology SC Neurosciences & Neurology GA PG390 UT WOS:A1994PG39000044 PM 7936316 ER PT J AU SCHOMER, PD AF SCHOMER, PD TI NEW DESCRIPTOR FOR HIGH-ENERGY IMPULSIVE SOUNDS SO NOISE CONTROL ENGINEERING JOURNAL LA English DT Article AB In 1981, Working Group 84 of the National Research Council, Committee on Hearing, Bioacoustics and Biomechanics, recommended C-weighted sound exposure and day-night average C-weighted sound level for assessment of high-energy impulsive sounds such as those generated by large military weapons, supersonic aircraft, and quarry or mining explosions. Studies conducted from about 1960 to 1990 showed that a linear relationship, with a slope statistically different from 1, exists between the C-weighted sound exposure level (CSEL) of a high-energy impulsive sound and the A-weighted sound exposure level (ASEL) of a non-impulsive control sound of equivalent annoyance. The slope was of the order of 0.5; i.e., a 1-dB change in the CSEL of high-energy impulsive sound corresponds to about a 2-dB change in the ASEL for a control sound of equivalent annoyance. Because of the non-unity slope, it is recommended that high-energy impulsive sounds be assessed by the level of an ''annoyance unit.'' Annoyance units double when the number of acoustical events double, but annoyance units quadruple when the C-weighted sound exposure doubles. (C) 1994 Institute of Noise Control Engineering. RP SCHOMER, PD (reprint author), USA,CONSTRUCT ENGN RES LABS,CHAMPAIGN,IL 61826, USA. NR 0 TC 12 Z9 12 U1 0 U2 0 PU INST NOISE CONTROL ENG PI POUGHKEEPSIE PA PO BOX 3206 ARLINGTON BRANCH, POUGHKEEPSIE, NY 12603 SN 0736-2501 J9 NOISE CONTROL ENG JI Noise Control Eng. J. PD SEP-OCT PY 1994 VL 42 IS 5 BP 179 EP 191 DI 10.3397/1.2828355 PG 13 WC Acoustics; Engineering, Multidisciplinary SC Acoustics; Engineering GA PM896 UT WOS:A1994PM89600003 ER PT J AU SEGEV, M CROSIGNANI, B DIPORTO, P YARIV, A DUREE, G SALAMO, G SHARP, E AF SEGEV, M CROSIGNANI, B DIPORTO, P YARIV, A DUREE, G SALAMO, G SHARP, E TI STABILITY OF PHOTOREFRACTIVE SPATIAL SOLITONS SO OPTICS LETTERS LA English DT Article ID MEDIA AB We present a theoretical analysis of the stability of photorefractive spatial solitons along with experimental results that show that the solitons are stable for small-scale perturbations but break down when the perturbations exhibit a transverse scale comparable with the soliton size (cross section). C1 CALTECH,PASADENA,CA 91125. UNIV ARKANSAS,DEPT PHYS,FAYETTEVILLE,AR 72701. UNIV LAQUILA,DIPARTIMENTO FIS,I-67100 LAQUILA,ITALY. FDN UGO BORDONI,ROME,ITALY. USA,RES LAB,FT BELVOIR,VA 22060. NR 6 TC 60 Z9 62 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD SEP 1 PY 1994 VL 19 IS 17 BP 1296 EP 1298 DI 10.1364/OL.19.001296 PG 3 WC Optics SC Optics GA PD417 UT WOS:A1994PD41700010 PM 19855499 ER PT J AU HITT, MA KEATS, BW HARBACK, HF NIXON, RD AF HITT, MA KEATS, BW HARBACK, HF NIXON, RD TI RIGHTSIZING - BUILDING AND MAINTAINING STRATEGIC LEADERSHIP AND LONG-TERM COMPETITIVENESS SO ORGANIZATIONAL DYNAMICS LA English DT Article AB Although many companies see ''downsizing'' as a way of maintaining competitive advantage, large-scale staff reductions seldom help an organization achieve its hoped-for objectives. Basing their findings on extensive field interviews, the authors identify both ineffective and effective downsizing tactics. Voluntary early retirements, say the authors, as well as across-the-board layoffs, are particularly dangerous. Effective tactics start with a concerted effort to ''rightsize'' the organization in view of a long-term corporate identity. By protecting core competencies and by emphasizing teamwork, training, and leadership during reduction, the organization stands a better chance of achieving its goals. C1 ARIZONA STATE UNIV,COLL BUSINESS,TEMPE,AZ 85287. USA,CHIEF STAFF,WASHINGTON,DC 20310. TULANE UNIV,AB FREEMAN SCH BUSINESS,NEW ORLEANS,LA 70118. RP HITT, MA (reprint author), TEXAS A&M UNIV,PAUL M & ROSALIE ROBERTSON CHAIR BUSINESS ADM,COLLEGE STN,TX 77843, USA. NR 20 TC 25 Z9 25 U1 1 U2 8 PU AMER MANAGEMENT ASSOC PI NEW YORK PA 135 W 50TH ST, NEW YORK, NY 10020 SN 0090-2616 J9 ORGAN DYN JI Organ. Dyn. PD FAL PY 1994 VL 23 IS 2 BP 18 EP 32 DI 10.1016/0090-2616(94)90066-3 PG 15 WC Business; Psychology, Applied; Management SC Business & Economics; Psychology GA PP230 UT WOS:A1994PP23000002 ER PT J AU WHITE, KL JARBOE, DL KRZYCH, U AF WHITE, KL JARBOE, DL KRZYCH, U TI IMMUNIZATION WITH IRRADIATED PLASMODIUM-BERGHEI SPOROZOITES INDUCES IL-2 AND IFN-GAMMA BUT NOT IL-4 SO PARASITE IMMUNOLOGY LA English DT Article DE MALARIA; PLASMODIUM BERGHEI; LYMPHOKINES; TH LYMPHOCYTES ID CD8+ T-CELLS; CIRCUMSPOROZOITE PROTEIN; MURINE MALARIA; INTERFERON-GAMMA; IMMUNE-RESPONSE; MICE; ANTIBODIES; CYTOKINES; ANTIGENS; INVITRO AB Protective immunity against Plasmodium induced by immunization with irradiated sporozoites (SPZ) depends on both humoral and cellular responses. Although circumsporozoite protein (CSP)-specific cytolytic T lymphocyte responses have been established as an effector system, other cell types are required for protection. We have previously demonstrated that although protective immunity and T cell proliferative reactivity to SPZ are mouse strain- and SPZ dose-dependent, no correlation between the two responses could be found. Since protective immunity involves functionally diverse T cell subsets, we asked whether the discordance between proliferative responses to SPZ and protective immunity might have resulted from selective activation of either the Th1 or Th2 cell subset. Protective immunity, in vitro proliferative responses, and lymphokine production were tested in BALB/c, C57B1/6, and C3H/HeN mice immunized according to different SPZ regimens. The levels of IL-2 paralleled the proliferative reactivities in each mouse strain examined. Although IFN gamma levels were present in the unprimed lymphocyte cultures, they increased following each SPZ immunization, in C57B1/6, moderate in C3H/ HeN, and lowest in BALB/c splenic cultures. Surprisingly, no IL-4 was detected in splenic cultures from any mouse strain during proliferative activity or protective immunity. In contrast, elevated IL-6 production was noted after each immunization, regardless of the protective status and it correlated with anti-CSP IgG serum levels. These data establish that lymphokine profiles corresponding primarily to the Th1 cells were induced by immunization with P. berghei SPZ and that IL-4 secreting T cells were not induced by the SPZ-stage berghei antigens. C1 CATHOLIC UNIV AMER,DEPT BIOL,WASHINGTON,DC 20064. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307. USAMC,AFRIMS,APO,AP 96546. NR 43 TC 6 Z9 6 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0141-9838 J9 PARASITE IMMUNOL JI Parasite Immunol. PD SEP PY 1994 VL 16 IS 9 BP 479 EP 491 PG 13 WC Immunology; Parasitology SC Immunology; Parasitology GA PL969 UT WOS:A1994PL96900004 PM 7838597 ER PT J AU CHANG, CI CHEN, K WANG, JW ALTHOUSE, MLG AF CHANG, CI CHEN, K WANG, JW ALTHOUSE, MLG TI A RELATIVE ENTROPY-BASED APPROACH TO IMAGE THRESHOLDING SO PATTERN RECOGNITION LA English DT Article DE THRESHOLDING; RELATIVE ENTROPY; LOCAL ENTROPY; JOINT ENTROPY; COOCCURRENCE MATRIX ID HISTOGRAM AB In this paper, we present a new image thresholding technique which uses the relative entropy (also known as the Kullback-Leiber discrimination distance function) as a criterion of thresholding an image. As a result, a gray level minimizing the relative entropy will be the desired threshold. The proposed relative entropy approach is different from two known entropy-based thresholding techniques, the local entropy and joint entropy methods developed by N. R. Pal and S. K. Pal in the sense that the former is focused on the matching between two images while the latter only emphasized the entropy of the co-occurrence matrix of one image. The experimental results show that these three techniques are image dependent and the local entropy and relative entropy seem to perform better than does the joint entropy. In addition, the relative entropy can complement the local entropy and joint entropy in terms of providing different details which the others cannot. As far as computing saving is concerned, the relative entropy approach also provides the least computational complexity. C1 USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. RP CHANG, CI (reprint author), UNIV MARYLAND,DEPT ELECT ENGN,BALTIMORE CTY CAMPUS,CATONSVILLE,MD 21228, USA. NR 12 TC 74 Z9 80 U1 3 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0031-3203 J9 PATTERN RECOGN JI Pattern Recognit. PD SEP PY 1994 VL 27 IS 9 BP 1275 EP 1289 DI 10.1016/0031-3203(94)90011-6 PG 15 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic SC Computer Science; Engineering GA PG657 UT WOS:A1994PG65700011 ER PT J AU SCHMALJOHN, C AF SCHMALJOHN, C TI PROSPECTS FOR VACCINES TO CONTROL VIRUSES IN THE FAMILY BUNYAVIRIDAE SO REVIEWS IN MEDICAL VIROLOGY LA English DT Review ID RIFT-VALLEY FEVER; KOREAN HEMORRHAGIC-FEVER; RENAL SYNDROME HFRS; AMINO-ACID-SEQUENCES; HANTAAN VIRUS; ETIOLOGIC AGENT; NEPHROPATHIA EPIDEMICA; MONOCLONAL-ANTIBODIES; ANTIGENIC DETERMINANTS; BACULOVIRUS EXPRESSION RP SCHMALJOHN, C (reprint author), USA,MED RES INST INFECT DIS,DIV VIROL,FT DETRICK,MD 21702, USA. NR 110 TC 14 Z9 15 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 1052-9276 J9 REV MED VIROL JI Rev. Med. Virol. PD SEP PY 1994 VL 4 IS 3 BP 185 EP 196 DI 10.1002/rmv.1980040305 PG 12 WC Virology SC Virology GA PM085 UT WOS:A1994PM08500004 ER PT J AU LIN, SS AF LIN, SS TI APPLICATION OF SHORT CARBON-FIBER IN CONSTRUCTION SO SAMPE JOURNAL LA English DT Article ID REINFORCED CEMENT COMPOSITES; CONCRETE AB Recent developments of short carbon fiber reinforced concretes are briefly summarized. A variety of commercial applications has been made since the first large scale construction in 1984. In spite of a high reinforcing fiber cost at the present time, usages are found in many special applications where the superior characteristics of carbon fiber are needed. The current construction usage for special concretes require light weight, long term durability, erosion resistance, low abrasion, low permeability, or electromagnetic shielding. The applications for reinforced concretes are expected to multiply due to decreased manufacturing cost of the fiber, and increased saving from a reduction time for construction. Possible future reinforcements by carbon fiber or hybrid fibers can be extended to include low cost ceramics RP LIN, SS (reprint author), USA,RES LAB,MAT DIRECTORATE,WATERTOWN,MA, USA. NR 20 TC 9 Z9 12 U1 0 U2 1 PU SAMPE PUBLISHERS PI COVINA PA 1161 PARKVIEW DRIVE, COVINA, CA 91722 SN 0091-1062 J9 SAMPE J JI Sampe J. PD SEP-OCT PY 1994 VL 30 IS 5 BP 39 EP 45 PG 7 WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary SC Engineering; Materials Science GA QZ181 UT WOS:A1994QZ18100004 ER PT J AU MATTHEW, CB AF MATTHEW, CB TI TREATMENT OF HYPERTHERMIA AND DEHYDRATION WITH HYPERTONIC SALINE IN DEXTRAN SO SHOCK LA English DT Article ID SMALL-VOLUME RESUSCITATION; SEVERE HEMORRHAGIC-SHOCK; 6-PERCENT DEXTRAN-70; 7.5-PERCENT NACL; BLOOD-FLOW; SODIUM-CHLORIDE; LIVER DAMAGE; SWINE; RAT; HEATSTROKE AB Hyperthermia may be accompanied by dehydration with or without electrolyte loss. To determine the efficacy of hypertonic saline in dextran solution (HSD, 7.5% NaCl in 6% dextran 70) for the treatment of heat stroke, rats were deprived of water for 24 h (DE) or not (ND), and then they were heat-stressed, and 4 mL/kg of saline (SAL) or HSD was administered via jugular cannula at the end of heat stress (a core temperature of 42.3 degrees C). The following four groups of 10 rats (Wistar-Furth) were used: NDSAL, DESAL, NDHSD, and DEHSD. Four control groups not subjected to heat stress were also studied. Percent change in plasma volume (PV) from baseline was significantly decreased by DE vs. ND (-6.8 +/- 1.2 vs. +4.6 +/- 1.6%) and increased by HSD vs. SAL (+10.1 +/- 4.1 vs. -3.5 +/- 1.6%) administration. Rats that were DE had significantly higher heating rates and less water loss during heat than ND rats, but hydration status was not correlated to 24 h survival. HSD groups had significantly higher PV and survival rates than their corresponding SAL groups regardless of hydrational status. RP MATTHEW, CB (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 42 TC 5 Z9 5 U1 0 U2 0 PU BIOMEDICAL PRESS PI AUGUSTA PA 1021 15TH ST, BIOTECH PARK STE 9, AUGUSTA, GA 30901 SN 1073-2322 J9 SHOCK JI Shock PD SEP PY 1994 VL 2 IS 3 BP 216 EP 221 PG 6 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA PL651 UT WOS:A1994PL65100010 PM 7538037 ER PT J AU JONES, BH COWAN, DN KNAPIK, JJ AF JONES, BH COWAN, DN KNAPIK, JJ TI EXERCISE, TRAINING AND INJURIES SO SPORTS MEDICINE LA English DT Review AB Although exercise results in a number of well documented physical fitness and health benefits, accruing such benefits entails a risk of exercise-related injuries. Musculoskeletal injuries occur frequently among fitness programme participants, runners, athletes, military recruits and others who engage in routine vigorous exercise. The same parameters of exercise (intensity, duration and frequency) that determine the positive fitness and health effects of physical training also appear to influence the risk of injuries. Studies of runners and other physically active groups have consistently demonstrated that greater duration and frequency of exercise are associated with higher risk of injury. However, the sports medicine literature shows little association between exercise intensity and injuries, a finding which may be misleading. The strongest and most consistent association reported exists between greater total amounts of exercise and higher risks of injury. This is not surprising, since the total amount of exercise is the product of the intensity, duration and frequency of exercise. Recent military research confirms the finding that higher volumes of running are associated with higher rates of injury. Furthermore, the study of army recruits suggests that greater amounts of exercise not only result in greater risks of injury, but in some instances may also impart no additional increase in fitness, a finding consistent with an earlier study of civilian runners. Several military studies also demonstrate that those recruits who have been more physically active in the past are less likely to be injured during basic training. These military studies also document a number of other factors, such as older age, smoking, sedentary jobs and lifestyle, high or low flexibility and high arches of the feet, which may contribute to or modify the risks for exercise-related injuries. In conclusion, the present review suggests that, for activities such as running, specific parameters of exercise may contribute to the overall risk of injuries in rough proportion to their contribution to the total amount of activity performed. Also, better knowledge of the effects of the parameters of training and other factors on the risks of exercise-related injuries is necessary to make more judicious choices about how to best achieve the benefits of exercise and to prevent injuries. RP JONES, BH (reprint author), USA,ENVIRONM MED RES INST,DIV OCCUPAT MED,KANSAS ST,NATICK,MA 01760, USA. NR 0 TC 106 Z9 110 U1 2 U2 11 PU ADIS INTERNATIONAL LTD PI AUCKLAND PA 41 CENTORIAN DR, PRIVATE BAG 65901, MAIRANGI BAY, AUCKLAND 10, NEW ZEALAND SN 0112-1642 J9 SPORTS MED JI Sports Med. PD SEP PY 1994 VL 18 IS 3 BP 202 EP 214 DI 10.2165/00007256-199418030-00005 PG 13 WC Sport Sciences SC Sport Sciences GA PG834 UT WOS:A1994PG83400005 PM 7809556 ER PT J AU MCDOWELL, CP ROTHBERG, JM KOSHES, RJ AF MCDOWELL, CP ROTHBERG, JM KOSHES, RJ TI WITNESSED SUICIDES SO SUICIDE AND LIFE-THREATENING BEHAVIOR LA English DT Article ID UNITED-STATES-ARMY AB Suicides that take place in the presence of others have not been the topic of systematic scientific inquiry. The so-called witnessed suicides account for a small percentage of all suicides but offer a unique view into the dynamics of self-destructive behavior. An epidemiologic and forensic description of 50 witnessed suicides drawn from a 15-year series of over 1,000 cases is presented. A taxonomy is developed based on the role played by the witness and related to previous work on self-destructive behavior and its motivation. Brief vignettes are used to illustrate some of the interpersonal dynamics associated with these deaths. C1 WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307. RP MCDOWELL, CP (reprint author), HEADQUARTERS AIR FORCE OFF SPECIAL INVEST,BOLLING AFB,DC 20332, USA. NR 18 TC 4 Z9 4 U1 1 U2 3 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 SN 0363-0234 J9 SUICIDE LIFE-THREAT JI Suicide Life-Threat. Behav. PD FAL PY 1994 VL 24 IS 3 BP 213 EP 223 PG 11 WC Psychiatry; Psychology, Multidisciplinary SC Psychiatry; Psychology GA PJ987 UT WOS:A1994PJ98700001 PM 7825194 ER PT J AU ROSSELL, CR BRITCHER, JJ AF ROSSELL, CR BRITCHER, JJ TI EVIDENCE OF PLURAL BREEDING BY RED-COCKADED WOODPECKERS SO WILSON BULLETIN LA English DT Note C1 USA,DIRECTORATE PUBL WORKS & ENVIRONM,ENDANGERED SPECIES BRANCH,FT BRAGG,NC 28307. NR 8 TC 1 Z9 1 U1 0 U2 1 PU WILSON ORNITHOLOGICAL SOC PI ANN ARBOR PA MUSEUM OF ZOOLOGY UNIV MICHIGAN, ANN ARBOR, MI 48109 SN 0043-5643 J9 WILSON BULL JI Wilson Bull. PD SEP PY 1994 VL 106 IS 3 BP 557 EP 559 PG 3 WC Ornithology SC Zoology GA PK023 UT WOS:A1994PK02300016 ER PT J AU ZHENG, JP KWOK, HS AF ZHENG, JP KWOK, HS TI EXCITON AND BIEXCITON RECOMBINATION IN SEMICONDUCTOR NANOCRYSTALS SO APPLIED PHYSICS LETTERS LA English DT Article ID DOPED GLASSES; PHASE-CONJUGATION; ULTRAFAST CARRIER; PICOSECOND; TEMPERATURE; RELAXATION; LIFETIMES; DYNAMICS AB The time-resolved photoluminescence of semiconductor nanocrystals was obtained as a function of laser excitation intensity at a low temperature. Exciton and biexciton recombination processes were clearly identified. At laser intensities lower than 3.3 x 10(5) W/cm2, only exciton recombination with a lifetime of 4 ns was obtained. At higher laser intensities, biexciton recombination with a lifetime of 1 ns appeared. At laser intensities above 10(6) W/cm2, recombination of electron-hole plasma occurred with a much shorter lifetime. C1 HONG KONG UNIV SCI & TECHNOL,DEPT ELECT & ELECTR ENGN,CLEARWATER BAY,HONG KONG. RP ZHENG, JP (reprint author), USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703, USA. NR 17 TC 7 Z9 7 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD AUG 29 PY 1994 VL 65 IS 9 BP 1151 EP 1153 DI 10.1063/1.112125 PG 3 WC Physics, Applied SC Physics GA PE158 UT WOS:A1994PE15800029 ER PT J AU KATRITZKY, AR BELYAKOVA, SA DURST, HD AF KATRITZKY, AR BELYAKOVA, SA DURST, HD TI SYNTHESIS OF THE FIRST LARIAT CROWN-FORMAZAN, PROTOTYPE OF A NEW SERIES OF PODANDOCORONANDS SO TETRAHEDRON LETTERS LA English DT Article ID CHAIN-LENGTH; ETHERS AB Crown-formazan (1) with a pendant hydroxy group was obtained by a phase-transfer assisted ate-coupling reaction. Acylation of the hydroxy group of (1) with 2-chloroacetyl chloride followed by reaction with dimethylamine afforded 13-[2-(N,N-dimethylamino)acetoxy]-16,17-dihydro-7-phenyl-5H,15-dibenzo[b,il[l,ll ,4,5,7,8]dioxatetraazacyclotetradecyne (8), the first lariat crown-formazan containing a strong donor group as a supporting ligand at the end of the side arm. C1 USA,EDGEWOOD RES,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP KATRITZKY, AR (reprint author), UNIV FLORIDA,CTR HETEROCYCL CPDS,DEPT CHEM,GAINESVILLE,FL 32611, USA. NR 12 TC 9 Z9 9 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0040-4039 J9 TETRAHEDRON LETT JI Tetrahedron Lett. PD AUG 29 PY 1994 VL 35 IS 35 BP 6465 EP 6468 DI 10.1016/S0040-4039(00)78247-5 PG 4 WC Chemistry, Organic SC Chemistry GA PE670 UT WOS:A1994PE67000017 ER PT J AU HILBERT, DM ANDERSON, AO HOLMES, KL RUDIKOFF, S AF HILBERT, DM ANDERSON, AO HOLMES, KL RUDIKOFF, S TI LONG-TERM LYMPHOID RECONSTITUTION OF SCID MICE SUGGESTS SELF-RENEWING B-CELL AND T-CELL POPULATIONS IN PERIPHERAL AND MUCOSAL TISSUES SO TRANSPLANTATION LA English DT Article ID MURINE PEYERS PATCH; GUT LAMINA PROPRIA; IGA PLASMA-CELLS; IMMUNOGLOBULIN PRODUCTION; HOMING RECEPTOR; LYMPHOCYTES; EXPRESSION; MOLECULE; GLYCOPROTEIN; SPECIFICITY AB Peyer's patch, peripheral lymph node, and mesenteric lymph node cells were transferred to immunodeficient SCID mice to assess the long-term (150-300 days) potential of these cells to repopulate the host's immune system. Results demonstrate that, irrespective of donor population, total serum Ig and isotype distribution appear normal within 4 weeks of reconstitution and remain at normal levels for up to one year following cell transfer. At the cellular level, each donor population reconstitutes splenic T and B cell compartments in a progressive and quantitatively indistinguishable manner. Immunohistological analyses of reconstituted mice indicate that, although some qualitative differences are evident, normal splenic composition and architecture are observed. In contrast, gut reconstitution varies significantly with donor population. Peyer's patch cells yield normal-appearing gut tissue with extensive infiltration of the lamina propria and intraepithelial compartments by T cells and IgA-secreting plasma cells. Peripheral lymph node cells give rise to T cells found almost exclusively in the lamina propria, while IgA secreting plasma cells are rarely detected. The course and extent of reconstitution further suggest that all donor populations contain long-lived T and B cells as well as self-renewing lymphocytes capable of extensive expansion. This latter observation has potentially important implications for both transplantation biology and gene therapy applications. C1 NIH,BETHESDA,MD 20892. USA,MED RES INST INFECT DIS,DEPT RESP & MUCOSAL IMMUNOL,FT DETRICK,MD 21701. NIAID,BIOL RESOURCES BRANCH,FLOW CYTOMETRY SECT,BETHESDA,MD 20892. RP HILBERT, DM (reprint author), NCI,GENET LAB,BLDG 37,RM 2B15,BETHESDA,MD 20892, USA. NR 39 TC 13 Z9 13 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0041-1337 J9 TRANSPLANTATION JI Transplantation PD AUG 27 PY 1994 VL 58 IS 4 BP 466 EP 475 DI 10.1097/00007890-199408270-00013 PG 10 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA PE120 UT WOS:A1994PE12000013 PM 8073516 ER PT J AU POOLA, I KIANG, JG AF POOLA, I KIANG, JG TI THE ESTROGEN-INDUCIBLE TRANSFERRIN RECEPTOR-LIKE MEMBRANE GLYCOPROTEIN IS RELATED TO STRESS-RELATED PROTEINS SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID HEAT-SHOCK PROTEIN; AMINO-ACID SEQUENCE; CHICKEN; OVOTRANSFERRIN; BINDING; CELLS; GENES; NITROCELLULOSE; EXPRESSION; MOLECULES AB It was previously shown that estrogen induces a membrane glycoprotein (molecular mass, 95 kDa) in the chicken oviducts, which exhibits several properties similar to transferrin receptors (Poola, I., and Lucas, J. J. (1988) J. Biol. Chem. 263, 19137-19146). In the present study, we have further investigated its molecular and transferrin binding properties. We have sequenced several internal peptides isolated from the purified protein by endopeptidase Lys-C. We have found that it has a high degree of sequence homologies with those of chicken heat-shock protein (cHsp108), mouse endoplasmic reticulum protein (mERp99), hamster glucose-regulated protein (hagrp94), and human tumor rejection antigen hTRAgp96), all of which are shown to be highly homologous to each other and to yeast hsp90. We demonstrate here that the [S-35]methionine-labeled immunoaffinity-purified estrogen-inducible membrane glycoprotein binds to the transferrin affinity columns similar to iron-modulated transferrin receptors. Indirect immunofluorescence microscopic studies indicate that it is an intracellular glycoprotein unlike transferrin receptors. We have isolated two molecular forms of the protein, with molecular masses of 116 and 104 kDa, by immunoaffinity column purification, immunoprecipitation, Western blotting, and pulse-chase labeling analyses. Both 116- and 104-kDa species bind transferrin. This protein can be induced by heat shocking the oviduct cells at 45 degrees C for 3 h and recovering at 37 degrees C for 2-3 h. It is also expressed in the human breast cancer cell lines, MCF-7 and T-47D. All these properties taken together strongly suggest that the estrogen-inducible membrane glycoprotein is a novel transferrin-binding protein, structurally related to the stress-regulated proteins. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT CLIN PHYSIOL,DIV MED,WASHINGTON,DC 20307. RP POOLA, I (reprint author), JOHNS HOPKINS UNIV,SCH MED,DEPT MED,DIV HEMATOL,924 TRAYLOR BLDG,720 RUTLAND AVE,BALTIMORE,MD 21205, USA. NR 44 TC 29 Z9 30 U1 0 U2 2 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD AUG 26 PY 1994 VL 269 IS 34 BP 21762 EP 21769 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA PK973 UT WOS:A1994PK97300058 PM 8063820 ER PT J AU KWOK, TJ JAYASURIYA, K DAMAVARAPU, R BRODMAN, BW AF KWOK, TJ JAYASURIYA, K DAMAVARAPU, R BRODMAN, BW TI APPLICATION OF H-ZSM-5 ZEOLITE FOR REGIOSELECTIVE MONONITRATION OF TOLUENE SO JOURNAL OF ORGANIC CHEMISTRY LA English DT Article ID BENZOYL NITRATE; CATALYSTS; SOLIDS AB The nitration of toluene with n-propyl nitrate has been carried out in the presence of H-ZSM-5 as the catalyst. Several H-ZSM-5 catalysts with different Si/Al ratios were investigated to determine the influence of varying Si/Al ratios on the catalytic activity. It was found that high Si/Al ratios enhanced the regioselectivity for the p-nitrotoluene over the ortho isomer under comparable conditions. The best o:m:p product distribution (5:0:95) was achieved using H-ZSM-5 with a Si/Al ratio of 1000. The isolable yield is 54%. In contrast to conventional nitration methods, the product distribution reported in this study is remarkable. RP KWOK, TJ (reprint author), USA,ARDEC,DIV ENERGET MAT,GEO CTR INC,BLDG 3028,PICATINNY ARESENAL,NJ 07806, USA. NR 28 TC 59 Z9 66 U1 0 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3263 J9 J ORG CHEM JI J. Org. Chem. PD AUG 26 PY 1994 VL 59 IS 17 BP 4939 EP 4942 DI 10.1021/jo00096a042 PG 4 WC Chemistry, Organic SC Chemistry GA PE443 UT WOS:A1994PE44300042 ER PT J AU WILSON, RG SCHWARTZ, RN ABERNATHY, CR PEARTON, SJ NEWMAN, N RUBIN, M FU, T ZAVADA, JM AF WILSON, RG SCHWARTZ, RN ABERNATHY, CR PEARTON, SJ NEWMAN, N RUBIN, M FU, T ZAVADA, JM TI 1.54-MU-M PHOTOLUMINESCENCE FROM ER-IMPLANTED GAN AND ALN SO APPLIED PHYSICS LETTERS LA English DT Article ID ERBIUM; GAAS AB We report the observation of the 1.54-mum luminescence of optically excited Er3+ in ion-implanted epitaxially grown GaN and AlN films using below band-gap excitation. The Er-implanted layers were co-implanted with oxygen. At room temperature, this luminescence for GaN grown on sapphire is nearly as intense as it is at 6 or 77 K and exhibits many resolved transitions between crystal-field levels of the 4I13/2 first excited multiplet and the 4I15/2 ground multiplet. C1 UNIV FLORIDA,DEPT MAT SCI & ENGN,GAINESVILLE,FL 32611. USA,RES OFF,RES TRIANGLE PK,NC 27709. LAWRENCE BERKELEY LAB,BERKELEY,CA 94720. RP WILSON, RG (reprint author), HUGHES RES LABS,MALIBU,CA 90265, USA. RI Newman, Nathan/E-1466-2011 OI Newman, Nathan/0000-0003-2819-9616 NR 21 TC 167 Z9 174 U1 0 U2 14 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD AUG 22 PY 1994 VL 65 IS 8 BP 992 EP 994 DI 10.1063/1.112172 PG 3 WC Physics, Applied SC Physics GA PC897 UT WOS:A1994PC89700022 ER PT J AU LONG, JB SKOLNICK, P AF LONG, JB SKOLNICK, P TI 1-AMINOCYCLOPROPANECARBOXYLIC ACID PROTECTS AGAINST DYNORPHIN A-INDUCED SPINAL-INJURY SO EUROPEAN JOURNAL OF PHARMACOLOGY LA English DT Article DE ACPC (1-AMINOCYCLOPROPANECARBOXYLIC ACID); NMDA (N-METHYL-D-ASPARTATE); NEURONAL INJURY; DYNORPHIN A; GLYCINE ID ASPARTATE RECEPTOR COMPLEX; GLYCINE MODULATORY SITE; RAT HINDLIMB PARALYSIS; CORD BLOOD-FLOW; NMDA RECEPTOR; NONOPIOID MECHANISMS; ANTAGONISTS; PEPTIDES; MOTOR; DYSFUNCTION AB Lumbar subarachnoid injection of dynorphin A causes an ischemia-induced neuronal degeneration and persistent hindlimb paralysis. The protective effects of a variety of competitive and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists indicate that activation of the NMDA receptor complex is essential for dynorphin A-induced spinal cord injury. 1-Aminocyclopropanecarboxylic acid (ACPC) is a high affinity, partial agonist at strychnine-insensitive glycine receptors associated with the NMDA receptor complex. Pretreatment of rats with ACPC (100 and 200 mg/kg, i.p., 30 min prior to dynorphin A) significantly eliminated the persistent hindlimb motor deficits and neuropathological changes produced by 20 nmol of this peptide. The neuroprotective effects of ACPC (100 mg/kg, i.p.) were abolished by parenteral administration of glycine (800 mg/kg, 30 min prior to ACPC), consistent with other in vivo and in vitro studies indicating that the pharmacological actions of ACPC are effected through strychnine-insensitive glycine receptors. When given instead as six daily injections (200 mg/kg, i.p.) followed by an injection-free day, ACPC also significantly improved neurological recovery following dynorphin-A injection. These results support earlier indications that: (1) activation of the NMDA receptor complex plays a critical role in mediating dynorphin A-induced rat spinal cord injury; (2) ACPC provides an effective means of antagonizing excitotoxic phenomena; and (3) chronic administration of ACPC can elicit a persistent change in the NMDA receptor complex. C1 NIDDK,NEUROSCI LAB,BETHESDA,MD 20892. RP LONG, JB (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307, USA. NR 40 TC 28 Z9 28 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0014-2999 J9 EUR J PHARMACOL JI Eur. J. Pharmacol. PD AUG 22 PY 1994 VL 261 IS 3 BP 295 EP 301 DI 10.1016/0014-2999(94)90120-1 PG 7 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA PD756 UT WOS:A1994PD75600009 PM 7813551 ER PT J AU KEWITSCH, AS SEGEV, M YARIV, A SALAMO, GJ TOWE, TW SHARP, EJ NEURGAONKAR, RR AF KEWITSCH, AS SEGEV, M YARIV, A SALAMO, GJ TOWE, TW SHARP, EJ NEURGAONKAR, RR TI FERROELECTRIC DOMAIN GRATINGS IN STRONTIUM BARIUM NIOBATE INDUCED BY PHOTOREFRACTIVE SPACE-CHARGE FIELDS SO PHYSICAL REVIEW LETTERS LA English DT Article ID SR0.75BA0.25NB2O6; HOLOGRAMS AB We demonstrate that illuminating a photoconducting strontium barium niobate crystal with a low intensity optical standing wave generates space charge fields which induce ferroelectric domain gratings. We study the formation and decay kinetics of these domain gratings using a short exposure technique and present a thermodynamic model of the fixing mechanism. C1 ROCKWELL INT CORP,INT SCI CTR,THOUSAND OAKS,CA 91360. USA,RES LAB,FT BELVOIR,VA 22060. UNIV ARKANSAS,DEPT PHYS,FAYETTEVILLE,AR 72701. RP KEWITSCH, AS (reprint author), CALTECH,DEPT APPL PHYS,PASADENA,CA 91125, USA. NR 15 TC 34 Z9 34 U1 0 U2 2 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD AUG 22 PY 1994 VL 73 IS 8 BP 1174 EP 1177 DI 10.1103/PhysRevLett.73.1174 PG 4 WC Physics, Multidisciplinary SC Physics GA PC884 UT WOS:A1994PC88400031 ER PT J AU BALL, DH CIMECIOGLU, AL KAPLAN, DL HUANG, SH AF BALL, DH CIMECIOGLU, AL KAPLAN, DL HUANG, SH TI SITE-SELECTIVE MODIFICATION OF POLYSACCHARIDES UNDER HOMOGENEOUS CONDITIONS - NEW ANHYDRO AND CATIONIC POLYMERS DERIVED FROM AMYLOSE AND PULLULAN SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RD&E CTR,NATICK,MA 01760. UNIV CONNECTICUT,INST MAT SCI,BIODEGRADABLE POLYMERS CONSORTIUM,STORRS,CT 06269. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 4 EP CELL PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA261 UT WOS:A1994PA26100602 ER PT J AU COHENADAD, R LORIMER, JW PHILLIPS, SL SALOMON, M AF COHENADAD, R LORIMER, JW PHILLIPS, SL SALOMON, M TI A CONSISTENT APPROACH FOR EVALUATED SOLUBILITY DATA SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV LYON 1,PHYSICOCHIM MINERAL LAB,F-69622 VILLEURBANNE,FRANCE. UNIV WESTERN ONTARIO,DEPT CHEM,LONDON N6A 3K7,ONTARIO,CANADA. CAMATX BASIC CHEM,ORINDA,CA 94563. USA,FT MONMOUTH,NJ 07703. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 25 EP IEC PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA261 UT WOS:A1994PA26102105 ER PT J AU LIN, AJ MILLER, R AGER, AL AF LIN, AJ MILLER, R AGER, AL TI ANTIMALARIAL ACTIVITY OF WATER-SOLUBLE AND LONG-ACTING DIHYDROARTEMISININ DERIVATIVES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. UNIV MIAMI,CTR TROP PARASIT DIS,MIAMI,FL 33177. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 29 EP MEDI PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA261 UT WOS:A1994PA26102822 ER PT J AU PIERCE, DE KING, DB WALLACE, S SADLER, GD AF PIERCE, DE KING, DB WALLACE, S SADLER, GD TI ANALYSIS OF CONTAMINANTS IN RECYCLED PETE BY THERMAL EXTRACTION GC MS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,RES LAB,AMSRL EP EC,EPSD,FT MONMOUTH,NJ 07703. RUSKA LABS INC,HOUSTON,TX 77063. SHELL OIL CO,DIV POLYESTER,AKRON,OH 44305. IIT,NCFST,SUMMIT ARGO,IL 60501. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 48 EP MACR PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA269 UT WOS:A1994PA26902069 ER PT J AU LIESKE, CN CLARK, JH MAXWELL, DM BLUMBERGS, P KNUTSON, PK AF LIESKE, CN CLARK, JH MAXWELL, DM BLUMBERGS, P KNUTSON, PK TI UNUSUAL SUBSTITUENT EFFECTS IN THE INHIBITION OF EEL ACETYLCHOLINESTERASE BY ORGANOPHOSPHINATES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,MRICD,APPL PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. CASH STEVENS INC,DETROIT,MI 48202. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 56 EP AGRO PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA261 UT WOS:A1994PA26100223 ER PT J AU FAMINI, GR LIPNICK, RL WHITE, WE AF FAMINI, GR LIPNICK, RL WHITE, WE TI USING THEORETICAL DESCRIPTORS IN STRUCTURE-ACTIVITY-RELATIONSHIPS - APPLICATIONS TO SOIL ADSORPTION AND TRANSPORT SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. US EPA,OFF POLLUT PREVENT & TOX 7403,WASHINGTON,DC 20460. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 65 EP GEOC PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA261 UT WOS:A1994PA26102010 ER PT J AU WHITE, WE AF WHITE, WE TI INTERACTIONS OF ALUMINUM HYDROXIDE SURFACES WITH ORGANOPHOSPHORUS COMPOUNDS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR DEV & ENGN,DEPT APP SCI & TECHNOL,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 67 EP GEOC PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA261 UT WOS:A1994PA26102012 ER PT J AU GROSS, RA KIM, JH GORKOVENKO, A KAPLAN, DL ALLEN, AL BALL, D AF GROSS, RA KIM, JH GORKOVENKO, A KAPLAN, DL ALLEN, AL BALL, D TI CONTROL OF SIDE-CHAIN FATTY-ACID COMPOSITION FOR THE NATURAL BIOEMULSIFIER EMULSAN PRODUCED BY ACINETOBACTER-CALCOACETICUS STRAIN RAG-1 SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV MASSACHUSETTS,DEPT CHEM,LOWELL,MA 01854. USA,NATICK RES & DEV LABS,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 73 EP ENVR PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA261 UT WOS:A1994PA26101580 ER PT J AU XU, XD JOHN, VT MCPHERSON, GL GRIMM, DA AKKARA, JA KAPLAN, DL AF XU, XD JOHN, VT MCPHERSON, GL GRIMM, DA AKKARA, JA KAPLAN, DL TI A NOVEL CHEMICAL-ENZYMATIC METHOD TO REMOVE AROMATICS FROM AQUEOUS STREAMS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 TULANE UNIV,COORDINATED INSTRUMENTAT FACIL,NEW ORLEANS,LA 70118. USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. TULANE UNIV,DEPT CHEM ENGN,NEW ORLEANS,LA 70118. TULANE UNIV,DEPT CHEM,NEW ORLEANS,LA 70118. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 91 EP ENVR PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA261 UT WOS:A1994PA26101598 ER PT J AU CALDWELL, DJ KUHLMANN, KJ AF CALDWELL, DJ KUHLMANN, KJ TI SMOKE PRODUCTION FROM ADVANCED COMPOSITE-MATERIALS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,MED RES DETACHMENT,WRIGHT PATTERSON AFB,OH 45433. MANTECH ENVIRONM INC,ARMSTRONG LAB,WRIGHT PATTERSON AFB,OH 45433. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 93 EP PMSE PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA269 UT WOS:A1994PA26901618 ER PT J AU FAMINI, GR DONOVAN, WH WILSON, LY AF FAMINI, GR DONOVAN, WH WILSON, LY TI USING THEORETICAL DESCRIPTORS IN STRUCTURE-ACTIVITY-RELATIONSHIPS - GC RETENTION INDEXES OF SULFUR VESICANTS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. LA SIERRA UNIV,DEPT CHEM,RIVERSIDE,CA 92515. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 94 EP COMP PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA261 UT WOS:A1994PA26101401 ER PT J AU STEMLER, FW KAMINSKIS, A TEZAKREID, TM STOTTS, RR MORAN, TS HURT, HH AHLE, NW AF STEMLER, FW KAMINSKIS, A TEZAKREID, TM STOTTS, RR MORAN, TS HURT, HH AHLE, NW TI CORRELATION OF ATMOSPHERIC AND INHALED BLOOD CYANIDE LEVELS IN MINIATURE PIGS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 95 EP PMSE PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA269 UT WOS:A1994PA26901620 ER PT J AU MAYORQA, MA JANUSZKIEWICZ, AJ LEHNERT, BE AF MAYORQA, MA JANUSZKIEWICZ, AJ LEHNERT, BE TI ENVIRONMENTAL NITROGEN-DIOXIDE EXPOSURE HAZARDS OF CONCERN TO THE US-ARMY SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT RESP,WASHINGTON,DC 20307. LOS ALAMOS NATL LAB,LOS PULM BIOL TOXICOL PROGRAM,LOS ALAMOS,NM 87544. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 96 EP PMSE PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA269 UT WOS:A1994PA26901621 ER PT J AU TATA, M KOMMAREDDI, NS JOHN, VT HERMAN, MF MCPHERSON, GL AKKARA, JA KAPLAN, DL AF TATA, M KOMMAREDDI, NS JOHN, VT HERMAN, MF MCPHERSON, GL AKKARA, JA KAPLAN, DL TI SURFACTANT ASSISTED FOLDING OF PHENOL POLYMERS IN INVERSE MICROEMULSIONS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 TULANE UNIV,DEPT CHEM,NEW ORLEANS,LA 70118. TULANE UNIV,DEPT CHEM ENGN,NEW ORLEANS,LA 70118. USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 150 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA269 UT WOS:A1994PA26901165 ER PT J AU MANAA, MR AF MANAA, MR TI NONADIABATIC STABILITY OF HIGH-ENERGY DENSITY MATERIALS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,RES LAB,AMSRL,WT,PC,ABERDEEN PROVING GROUND,MD 21005. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 158 EP PHYS PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA269 UT WOS:A1994PA26900770 ER PT J AU FAMINI, GR CRONCE, DT WILSON, LY AF FAMINI, GR CRONCE, DT WILSON, LY TI APPLYING THE THEORETICAL LINEAR SOLVATION ENERGY RELATIONSHIP TO CORRELATING THE PROPERTIES OF SOLUTES IN POLYMERS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USN,CTR SURFACE WARFARE,DAHLGREN,VA 22448. USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. LA SIERRA UNIV,DEPT CHEM,RIVERSIDE,CA 92515. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 161 EP COMP PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA261 UT WOS:A1994PA26101468 ER PT J AU SPENCE, KE WANG, S POMETTO, A JANE, J AF SPENCE, KE WANG, S POMETTO, A JANE, J TI BIODEGRADATION OF PROTEIN STARCH-BASED PLASTICS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 IOWA STATE UNIV SCI & TECHNOL,CTR CROPS UTILIZAT RES,AMES,IA 50011. IOWA STATE UNIV SCI & TECHNOL,DEPT FOOD SCI & HUMAN NUTR,AMES,IA 50011. USA,NATICK RES CTR,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 242 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA269 UT WOS:A1994PA26901256 ER PT J AU MAYER, JM STOTE, RE MCCASSIE, JE DIXON, KL KAPLAN, DL AF MAYER, JM STOTE, RE MCCASSIE, JE DIXON, KL KAPLAN, DL TI MARINE AND SOIL BIODEGRADATION OF VARIOUS BIOPOLYMERS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR RD&E,DIV BIOTECHNOL,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 248 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA269 UT WOS:A1994PA26901262 ER PT J AU DANIEL, RG MCNESBY, KL MIZIOLEK, AW AF DANIEL, RG MCNESBY, KL MIZIOLEK, AW TI INFRARED-SPECTROSCOPY OF PREMIXED METHANE OXYGEN FLAMES INHIBITED BY HALONS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 249 EP ENVR PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA261 UT WOS:A1994PA26101756 ER PT J AU ZOEFFEL, LD CLARK, CR MAXWELL, DM LIESKE, CN LOWE, JR AF ZOEFFEL, LD CLARK, CR MAXWELL, DM LIESKE, CN LOWE, JR TI THERMODYNAMIC STUDIES OF CYANOLYSIS USING ELEMENTAL SULFUR SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,MRICD,ABERDEEN PROVING GROUND,MD 21010. PROGRAMMING CONSULTANTS,BRADDOCK HTS,MD 21714. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 254 EP MEDI PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA261 UT WOS:A1994PA26103047 ER PT J AU FINNERTY, AE AF FINNERTY, AE TI THE US-ARMY REQUIREMENT FOR A REPLACEMENT AGENT FOR HALON-1301 SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 280 EP ENVR PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA261 UT WOS:A1994PA26101787 ER PT J AU BURGESS, DRF WESTMORELAND, PR TSANG, W ZACHARIAH, MR MIZIOLEK, AW DANIEL, RG MCNESBY, KL AF BURGESS, DRF WESTMORELAND, PR TSANG, W ZACHARIAH, MR MIZIOLEK, AW DANIEL, RG MCNESBY, KL TI KEY SPECIES AND IMPORTANT REACTIONS IN FLUORINATED HYDROCARBON FLAME CHEMISTRY - PREMIXED FLAME SIMULATIONS AND MEASUREMENTS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 NATL INST STAND & TECHNOL,GAITHERSBURG,MD 20899. USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 286 EP ENVR PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA261 UT WOS:A1994PA26101793 ER PT J AU SLOAN, JM BODNAR, SC GILBERT, MD AF SLOAN, JM BODNAR, SC GILBERT, MD TI PERMEATION OF DMSO THROUGH NEOPRENE AND NATURAL-RUBBER MEMBRANES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,RES LAB,POLYMER RES BRANCH,WATERTOWN,MA 02172. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 290 EP PMSE PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA269 UT WOS:A1994PA26901814 ER PT J AU DAVE, V RATTO, JA ROUT, DK GROSS, RA KAPLAN, DL MCCARTHY, SP AF DAVE, V RATTO, JA ROUT, DK GROSS, RA KAPLAN, DL MCCARTHY, SP TI LIQUID-CRYSTALLINE BEHAVIOR OF KONJAC GLUCOMANNAN IN AQUEOUS-SOLUTIONS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV MASSACHUSETTS,DEPT CHEM,LOWELL,MA 01854. UNIV MASSACHUSETTS,DEPT PLAST ENGN,LOWELL,MA 01854. USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 291 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA269 UT WOS:A1994PA26901305 ER PT J AU PETKA, WA MCGRATH, KP KAPLAN, DL FOURNIER, MJ MASON, TL TIRRELL, DA AF PETKA, WA MCGRATH, KP KAPLAN, DL FOURNIER, MJ MASON, TL TIRRELL, DA TI SURFACE RECOGNITION AND DIFFUSION OF ENGINEERED MACROMOLECULES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV MASSACHUSETTS,DEPT POLYMER SCI & ENGN,AMHERST,MA 01003. UNIV MASSACHUSETTS,DEPT BIOCHEM & MOLEC BIOL,AMHERST,MA 01003. USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 293 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA269 UT WOS:A1994PA26901307 ER PT J AU POSNER, GH OH, CH WANG, D GERENA, L MILHOUS, WK MESHNICK, SR ASAWAMAHASADKA, W AF POSNER, GH OH, CH WANG, D GERENA, L MILHOUS, WK MESHNICK, SR ASAWAMAHASADKA, W TI THE IMPORTANCE OF A CARBON-CENTERED RADICAL FOR ANTIMALARIAL ACTIVITY SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 JOHNS HOPKINS UNIV,DEPT CHEM,BALTIMORE,MD 21218. WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. UNIV MICHIGAN,SCH PUBL HLTH,DEPT EPIDEMIOL,ANN ARBOR,MI 48109. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 302 EP ORGN PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA269 UT WOS:A1994PA26900377 ER PT J AU ASHLEY, PR GULOTTY, RJ LANGHOFF, CA NEWSHAM, MD AF ASHLEY, PR GULOTTY, RJ LANGHOFF, CA NEWSHAM, MD TI EO POLYMERIC DEVICES FOR FIBER OPTICAL GYROSCOPE APPLICATIONS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,MISSILE COMMAND,CM,WS,RD,AMSMI,WEAPONS SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898. DOW CHEM CO USA,CENT RES & DEV,MIDLAND,MI 48674. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 346 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA269 UT WOS:A1994PA26901360 ER PT J AU GUISEPPIELIE, A WILSON, AM LINDEN, CL PEARCE, FJ WIESMANN, WP GLICK, DL AF GUISEPPIELIE, A WILSON, AM LINDEN, CL PEARCE, FJ WIESMANN, WP GLICK, DL TI A CONDUCTIMETRIC H(2)O(2) SENSITIVE ELECTROCONDUCTIVE POLYMER TRANSDUCER FOR DEVELOPMENT OF OXIDOREDUCTASE ENZYME BIOSENSORS AND OXIDOREDUCTASE LABELED IMMUNOSENSORS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 AAI ABTECH,YARDLEY,PA 19067. KINGS COLL,DEPT BIOL & BIOTECHNOL,WILKES BARRE,PA 18711. WALTER REED ARMY INST RES,DIV SURG,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 353 EP PMSE PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA269 UT WOS:A1994PA26901877 ER PT J AU TRIPATHY, SK CHEN, ZP CHITTIBABU, KG MARX, KA KUMAR, J SAMUELSON, LA AKKARA, J KAPLAN, DL AF TRIPATHY, SK CHEN, ZP CHITTIBABU, KG MARX, KA KUMAR, J SAMUELSON, LA AKKARA, J KAPLAN, DL TI CONDUCTING POLYMER AND SOL-GEL ENCAPSULATED PHOTODYNAMIC PROTEIN AS BIOMATERIALS FOR SIGNAL-TRANSDUCTION SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV MASSACHUSETTS,CTR ADV MAT,LOWELL,MA 01854. USA,CTR RD&E,DIV BIOTECHNOL,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 21 PY 1994 VL 208 BP 420 EP PMSE PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA PA269 UT WOS:A1994PA26901944 ER PT J AU LINDLER, LE AF LINDLER, LE TI NUCLEOTIDE-SEQUENCE OF THE ESCHERICHIA-COLI GROE PROMOTER SO GENE LA English DT Note DE HEAT SHOCK; -10 REGION; -35 REGION; REGULON; GENE EXPRESSION; RNA POLYMERASE SIGMA FACTOR; INDUCTION ID PROTEIN; GENE; CLONING AB The promoter region of the Escherichia coli groE operon was cloned using the polymerase chain reaction (PCR). The 118-bp nucleotide sequence of the cloned groE promoter was determined on both strands of DNA. Two bp were found between the -10 and -35 regions of this promoter that have not been reported in previous publications of this sequence. RP LINDLER, LE (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307, USA. NR 11 TC 4 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-1119 J9 GENE JI Gene PD AUG 19 PY 1994 VL 146 IS 1 BP 129 EP 130 DI 10.1016/0378-1119(94)90846-X PG 2 WC Genetics & Heredity SC Genetics & Heredity GA PD300 UT WOS:A1994PD30000021 PM 8063097 ER PT J AU CHEN, ZX AF CHEN, ZX TI BDM MIXED METHODS FOR A NONLINEAR ELLIPTIC PROBLEM SO JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS LA English DT Article DE MIXED METHOD; ERROR ESTIMATE; NONLINEAR ELLIPTIC PROBLEM; BDM ELEMENT ID FINITE-ELEMENT METHODS; EXISTENCE AB A new mixed formulation is introduced to approximate the solution of a nonlinear elliptic problem based on the Brezzi-Douglas-Marini mixed finite elements. The existence and uniqueness of solutions of the mixed formulation and its discretization are demonstrated. Optimal error estimates in L2(OMEGA), L(infinity)(OMEGA) and H(-s)(OMEGA) are derived. Numerical results are presented to compare the present approach with the standard one and to justify the theoretical results obtained here. C1 UNIV MINNESOTA, ARMY HIGH PERFORMANCE COMP RES CTR, MINNEAPOLIS, MN 55455 USA. NR 11 TC 18 Z9 18 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0377-0427 EI 1879-1778 J9 J COMPUT APPL MATH JI J. Comput. Appl. Math. PD AUG 19 PY 1994 VL 53 IS 2 BP 207 EP 223 DI 10.1016/0377-0427(94)90046-9 PG 17 WC Mathematics, Applied SC Mathematics GA QB172 UT WOS:A1994QB17200005 ER PT J AU SALOMON, M XU, MZ EYRING, EM PETRUCCI, S AF SALOMON, M XU, MZ EYRING, EM PETRUCCI, S TI MOLECULAR-STRUCTURE AND DYNAMICS OF LICLO4 POLYETHYLENE OXIDE-400 (DIMETHYL ETHER AND DIGLYCOL SYSTEMS) AT 25-DEGREES-C SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID PROPYLENE CARBONATE; RELAXATION DYNAMICS; LITHIUM-SALTS; CONDUCTANCE; 2-METHYLTETRAHYDROFURAN; TETRAHYDROFURAN AB Infrared spectra of the <(nu)over bar>(4) mode of the ClO4- ion, for the systems LiClO4-polyethylene oxide dimethyl ether of average molar mass 400 (PEG-400) and LiClO4-polyethylene oxide glycol of average molar mass 400 (PEG-400), at 25 degrees C, have been determined and quantitatively described by the sum of two Gaussian-Lorentzian product functions centred at similar to 623 and similar to 635 cm(-1), respectively. Bands are assigned to spectroscopically free ClO4- (at similar to 623 cm(-1)) and to bound ClO4- (at similar to 635 cm(-1)). From the relative amplitudes of the two bands, it is concluded that the majority of the ClO4- exists out of contact with Li+, probably as solvent-separated ion pairs. This conclusion is based on a large ion-pair formation constant K-p = 4.5(2) X 10(3) for LiClO4 in PEO-400, as reported in the literature and reanalyzed in this work. Electrical conductance data for LiClO4 in PEG-400 are also reported and analyzed with current theories furnishing values of K-p for this system. Existence of dimer aggregates (Li+SxClO4-)(2), with S symbolizing an oxygen moiety of a polyether chain, is inferred from ultrasonic relaxation spectra of LiClO4-PEO systems. The presence of some (LiClO4)(2) dimeric contact species is also inferred. The ultrasonic absorption spectra show two relaxation processes followed, at high frequency, by a solvent relaxation process. Matrix analysis has been applied to the two-step dimerization process 2LiClO(4) reversible arrow LiClO4...LiClO4 reversible arrow (LiClO4)(2) (which is used to interpret the electrolyte ultrasonic relaxation processes). The analysis yields all the rate and equilibrium constants for the above steps. In addition, from the amplitude of the ultrasonic spectra, the isoentropic volume changes of the two normal modes, associated with the above equilibria, are calculated. The larger shear viscosity of the PEG solvent precludes the measurement of the solute ultrasonic relaxation in this medium. The molecular dynamics of the above systems have also been explored through microwave and far-infrared dielectric spectra measured in the frequency range from 0.4 GHz to 15 THz (i.e. 500 cm(-1)). The spectra are quantitatively described by the sum of a Cole-Cole distribution, operative mainly in the UHF-microwave region, and of three Powles-Rocard component bands (recently discussed in the literature) that are operative mainly at IR frequencies. In the microwave region, the Cole-Cole distribution describes the ethereal chain segmentational rotation, influenced by Li+ cations that increase the intertangling of the ethereal chains. In the far-IR region the highest frequency Powles-Rocard band at similar to 300 cm(-1) has been assigned, in accordance with the literature, to torsion of ethereal chains. The other two bands are probably due to librations, namely to hindered molecular rotations limited to small angles. Molar refractivities for LiClO4 in PEO-400 and in PEG-400 have been determined in a concentration range comparable to that used in the above work. C1 USA,FT MONMOUTH,NJ 07703. UNIV UTAH,DEPT CHEM,SALT LAKE CITY,UT 84112. POLYTECH INST NEW YORK,WEBER RES INST,FARMINGDALE,NY 11735. NR 43 TC 128 Z9 129 U1 2 U2 31 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD AUG 18 PY 1994 VL 98 IS 33 BP 8234 EP 8244 DI 10.1021/j100084a047 PG 11 WC Chemistry, Physical SC Chemistry GA PC619 UT WOS:A1994PC61900047 ER PT J AU WIESEN, AR HOSPENTHAL, DR BYRD, JC GLASS, KL HOWARD, RS DIEHL, LF AF WIESEN, AR HOSPENTHAL, DR BYRD, JC GLASS, KL HOWARD, RS DIEHL, LF TI EQUILIBRATION OF HEMOGLOBIN CONCENTRATION AFTER TRANSFUSION IN MEDICAL INPATIENTS NOT ACTIVELY BLEEDING SO ANNALS OF INTERNAL MEDICINE LA English DT Note ID UNITED-STATES; BLOOD; COLLECTION C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 19 TC 34 Z9 36 U1 0 U2 1 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD AUG 15 PY 1994 VL 121 IS 4 BP 278 EP 280 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA PB102 UT WOS:A1994PB10200009 PM 8037410 ER PT J AU WRIGHT, DG KENNEY, RF OETTE, DH LARUSSA, VF BOXER, LA MALECH, HL AF WRIGHT, DG KENNEY, RF OETTE, DH LARUSSA, VF BOXER, LA MALECH, HL TI CONTRASTING EFFECTS OF RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR (CSF) AND GRANULOCYTE CSF TREATMENT ON THE CYCLING OF BLOOD-ELEMENTS IN CHILDHOOD-ONSET CYCLIC NEUTROPENIA SO BLOOD LA English DT Article ID LARGE GRANULAR LYMPHOCYTES; GM-CSF; DRUG-THERAPY; GRANULOPOIESIS C1 NIAID,HOST DEF LAB,BETHESDA,MD 20892. SANDOZ INC,RES INST,E HANOVER,NJ 07936. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. UNIV MICHIGAN,CS MOTT CHILDRENS HOSP,MED CTR,PEDIAT HEMATOL ONCOL SECT,ANN ARBOR,MI 48109. BOSTON CITY HOSP,WILLIAM CASTLE HEMATOL RES LAB,BOSTON,MA 02118. RP WRIGHT, DG (reprint author), BOSTON UNIV,SCH MED,BCH THORNDIKE 2,818 HARRISON AVE,BOSTON,MA 02118, USA. FU NCRR NIH HHS [MO1RR0042]; NIAID NIH HHS [R01AI20065] NR 26 TC 24 Z9 24 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD AUG 15 PY 1994 VL 84 IS 4 BP 1257 EP 1267 PG 11 WC Hematology SC Hematology GA PC402 UT WOS:A1994PC40200034 PM 7519479 ER PT J AU SCALORA, M DOWLING, JP BOWDEN, CM BLOEMER, MJ AF SCALORA, M DOWLING, JP BOWDEN, CM BLOEMER, MJ TI THE PHOTONIC BAND-EDGE OPTICAL DIODE SO JOURNAL OF APPLIED PHYSICS LA English DT Article AB Using numerical methods, we study pulse propagation near the band edge of a one-dimensional photonic band gap material with a spatial gradiation in the linear refractive index, together with a nonlinear medium response. We find that such a structure can result in unidirectional pulse propagation. That is, the field will be transmitted for, say, a left-to-right direction of propagation, while for right-to-left nearly complete reflection occurs. This behavior constitutes the operational mechanism for a passive optical diode. RP SCALORA, M (reprint author), USA,AMSMI RD WS,MISSILE COMMAND,CTR DEV & ENGN,WEAP SCI DIRECTORATE RES,REDSTONE ARSENAL,AL 35898, USA. RI DOWLING, JONATHAN/L-2749-2013 NR 14 TC 201 Z9 213 U1 1 U2 16 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD AUG 15 PY 1994 VL 76 IS 4 BP 2023 EP 2026 DI 10.1063/1.358512 PG 4 WC Physics, Applied SC Physics GA PC021 UT WOS:A1994PC02100003 ER PT J AU PEROVICH, DK RICHTERMENGE, JA AF PEROVICH, DK RICHTERMENGE, JA TI SURFACE CHARACTERISTICS OF LEAD ICE SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID SEA-ICE; SNOW; EQUATIONS AB Under cold conditions, ice growth in a lead occurs rapidly, giving young sea ice a high bulk salinity. The surface characteristics of this ice type are dominated by a thin, highly saline surface skim and often by the formation of frost flowers. These surface characteristics are of particular interest because of their significant temporal variability and large impact on the electromagnetic properties of sea ice. As part of the Lead Experiment held during March and April of 1991 and 1992 in the Alaskan Beaufort Sea, ice properties and surface conditions typical of springtime leads were monitored at three sites during the initial few days of growth. Observations indicate that once the ice thickness reached approximately 2 cm, a thin (approximately 1 mm), highly saline (approximately 100 parts per thousand (ppt)) skim of brine formed on the surface. After only a few hours of growth the initially smooth surface of the sea ice developed some small-scale roughness. Frost flowers, the result of ice grown from the vapor phase, quickly formed on the surface of the sea ice and continued to develop during the observations. Depending on the temperature, the frost flowers were composed of various ice crystal types, including clumps, stellar dendrites, and needles. The initially fresh frost flowers quickly became salty, reaching salinities as high as 100 ppt. The salinity of both the frost flowers and the surface skim decreased at night as temperatures dropped and additional hoarfrost accumulated on the surface. These decreases were also due in part to the accumulation of snow on the surface of the leads. Combining these observations with simple calculations, possible mechanisms for the development and evolution of the surface skim and frost flowers are discussed. They include the hypothesis that the source of the surface skim is brine expelled upward from the sea ice as it cools, that the surface protrusions serve as nucleation sites for the frost flowers, and that the source of the excess water vapor necessary for frost flower growth is the wet surface skim. RP PEROVICH, DK (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 27 TC 111 Z9 111 U1 1 U2 11 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD AUG 15 PY 1994 VL 99 IS C8 BP 16341 EP 16350 DI 10.1029/94JC01194 PG 10 WC Oceanography SC Oceanography GA PC018 UT WOS:A1994PC01800026 ER PT J AU HOPKINS, MA AF HOPKINS, MA TI ON THE RIDGING OF INTACT LEAD ICE SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID SEA ICE AB The sea ice pressure ridging process is modeled using a two-dimensional particle simulation technique. In this model, blocks are broken from an intact sheet of relatively thin lead ice driven against a thick, multiyear floe at a constant speed. The blocks of ice rubble accumulate to form the ridge sail and keel. The energy consumed in ridge growth, including dissipation, is explicitly calculated. A series of numerical experiments are performed to establish the dependence of the energetics on the thickness of the ice sheet and the friction between blocks. The results suggest that the total energy required to create a pressure ridge is an order of magnitude greater than the potential energy in the ridge structure. A typical sea ice cover in the polar regions contains a variety of ice thicknesses that evolve in response to both dynamic and thermodynamic forcing. The variable thickness of the ice cover is created by deformation, which simultaneously causes formation of thick ice through ridge building and thin ice through lead creation. Since the energy expended in deformation is largely determined by the ridging process, an understanding of the energetics of pressure ridging is critical in the determination of ice strength on a geophysical scale. RP HOPKINS, MA (reprint author), COLD REG RES & ENGN LAB,ICE ENGN RES BRANCH,72 LYME RD,HANOVER,NH 03755, USA. NR 14 TC 43 Z9 44 U1 1 U2 4 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD AUG 15 PY 1994 VL 99 IS C8 BP 16351 EP 16360 DI 10.1029/94JC00996 PG 10 WC Oceanography SC Oceanography GA PC018 UT WOS:A1994PC01800027 ER PT J AU LEWIS, JK TUCKER, WB STEIN, PJ AF LEWIS, JK TUCKER, WB STEIN, PJ TI OBSERVATIONS AND MODELING OF THERMALLY-INDUCED STRESSES IN 1ST-YEAR SEA-ICE SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article AB During spring 1992, ice property, geophone, meteorological, and stress data were collected on first-year ice southwest of Cornwallis Island within the Canadian archipelago. One of the goals of the study was to specify the average characteristics of the ice, use these characteristics in a model of thermally induced stresses in the ice, and examine the fracturing associated with the occurrence of those stresses. The results of simulations with a thermal stress model indicate that stress variations within the ice can be reasonably approximated by a viscoelastic rheology. The rheology takes into consideration thermally induced strains generated locally as well as strains generated elsewhere and then mechanically transmitted through the ice. The geophone data showed both ice-borne and water-borne propagation paths for individual fracturing events. The data imply a detection radius out to 500-600 m for the ice-borne signatures of fractures. An investigation of a region after fracturing showed that (1) fracturing occurred in an area with a 10- to 15-cm snow cover, (2) the snow cover had been scored down to the surface of the ice, and (3) cracks in the ice were found under each location where the snow had been scored. The cracks were 5-6 m long and at least 15 cm deep. A review of these and other experimental results draw us to the conclusion that the forces required to produce fractures in response to natural forcing is greater for first-year floes than for multiyear floes. C1 SCI SOLUT INC,NASHUA,NH 03062. USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP LEWIS, JK (reprint author), OCEAN PHYS RES & DEV,207 S SEASHORE AVE,LONG BEACH,MS 39560, USA. NR 16 TC 13 Z9 13 U1 0 U2 1 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD AUG 15 PY 1994 VL 99 IS C8 BP 16361 EP 16371 DI 10.1029/94JC01242 PG 11 WC Oceanography SC Oceanography GA PC018 UT WOS:A1994PC01800028 ER PT J AU WHITNALL, MH ANDERSON, KA LANE, CA MOUGEY, EH NETA, R PERLSTEIN, RS AF WHITNALL, MH ANDERSON, KA LANE, CA MOUGEY, EH NETA, R PERLSTEIN, RS TI DECREASED VASOPRESSIN CONTENT IN PARVOCELLULAR CRH NEUROSECRETORY-SYSTEM OF LEWIS RATS SO NEUROREPORT LA English DT Article DE ADRENOCORTICOTROPIC HORMONE; CORTICOSTERONE; CORTICOTROPIN-RELEASING HORMONE; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MEDIAN EMINENCE; NERVE TERMINAL; SECRETORY GRANULES; VASOPRESSINS; LEWIS RAT ID CORTICOTROPIN-RELEASING HORMONE; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; TUMOR-NECROSIS-FACTOR; PARAVENTRICULAR NUCLEUS; ARGININE-VASOPRESSIN; MEDIAN-EMINENCE; INFLAMMATORY DISEASE; IMMUNE-SYSTEM; CORTICOSTERONE; SECRETION AB RATS possess stress-responsive, vasopressin (VP)-expressing and stress-nonresponsive, VP-deficient subpopulations of parvocellular corticotropin-releasing hormone (C RH) neurosecretory cells. Both subpopulations are activated by bacterial lipopolysaccharide (LPS) and cytokines. Lewis rats exhibit hyporesponsive hypothalamo-pituitary-adrenocortical axes (HPAAs). The Lewis CRH neurosecretory system has been reported to be defective in females and normal in males. We used post-embedding electron microscopic (EM) immunocytochemistry to study baseline levels and LPS-stimulated depletion of neurosecretory vesicles. Male Lewis rats possessed normal numbers of CRH+/VP- varicosities and low numbers of CRH+/VP+ varicosities, indicating abnormally tow release of VP into portal blood. This defect contrasts with the reported increase in VP content and release in magnocellular neurosecretory cells in Lewis rats. C1 ARMED FORCES RADIOBIOL RES INST, DEPT EXPTL HEMATOL, BETHESDA, MD 20889 USA. WALTER REED ARMY INST RES, DEPT MED NEUROSCI, NEUROENDOCRINOL & NEUROCHEM BRANCH, WASHINGTON, DC 20307 USA. RP ARMED FORCES RADIOBIOL RES INST, DEPT PHYSIOL, BETHESDA, MD 20889 USA. NR 25 TC 14 Z9 14 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0959-4965 EI 1473-558X J9 NEUROREPORT JI Neuroreport PD AUG 15 PY 1994 VL 5 IS 13 BP 1635 EP 1637 DI 10.1097/00001756-199408150-00023 PG 3 WC Neurosciences SC Neurosciences & Neurology GA PE032 UT WOS:A1994PE03200023 PM 7819536 ER PT J AU DAVE, JR TORTELLA, FC AF DAVE, JR TORTELLA, FC TI REGIONAL CHANGES IN C-FOS MESSENGER-RNA IN RAT-BRAIN AFTER IV-NMDA OR ICV-NMDA NMDA INJECTIONS SO NEUROREPORT LA English DT Article DE NMDA RECEPTOR; C-FOS MESSENGER-RNA; BRAIN REGIONS; CONVULSIONS; ROUTE OF ADMINISTRATION ID CEREBELLAR GRANULE CELLS; MESSENGER-RNA; PRIMARY CULTURES; MOUSE-BRAIN; EXPRESSION; ACTIVATION; INCREASE; NEURONS; ACID AB THESE studies were undertaken to determine if convulsant doses of i.c.v. vs i.v. administered NMDA exhibit differential specificity for anatomical regions of the brain in stimulating c-fos. In rats i.c.v. or i.v. NMDA produced behaviorally similar clonic (popcorn) convulsions associated with transient increases in c-fos mRNA in different brain areas. Transcription of c-fos mRNA peaked at 30 min post-treatment regardless of the route of administration. However, the route of administration clearly influenced the anatomical specificity of the NMDA-induced c-fos mRNA changes. For example, following i.c.v. administration maximal stimulation in c-fos mRNA was measured in the cerebellum. In contrast, i.v. NMDA produced maximal c-fos mRNA stimulation in the cerebral cortex. Our results demonstrate that NMDA has differential anatomical specificity for molecular signaling in rat brain and suggest that the route of NMDA administration may influence its pathophysiological response. RP DAVE, JR (reprint author), WALTER REED ARMY INST RES,DEPT MED NEUROSCI,NEUROPHARMACOL BRANCH,WRAMC,BLDG 40,WASHINGTON,DC 20307, USA. NR 20 TC 10 Z9 10 U1 0 U2 0 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0959-4965 J9 NEUROREPORT JI Neuroreport PD AUG 15 PY 1994 VL 5 IS 13 BP 1645 EP 1648 DI 10.1097/00001756-199408150-00026 PG 4 WC Neurosciences SC Neurosciences & Neurology GA PE032 UT WOS:A1994PE03200026 PM 7819539 ER PT J AU DUREE, G SALAMO, G SEGEV, M YARIV, A CROSIGNANI, B DIPORTO, P SHARP, E AF DUREE, G SALAMO, G SEGEV, M YARIV, A CROSIGNANI, B DIPORTO, P SHARP, E TI DIMENSIONALITY AND SIZE OF PHOTOREFRACTIVE SPATIAL SOLITONS SO OPTICS LETTERS LA English DT Article ID MEDIA AB We study experimentally self-trapping of optical beams in photorefractive media and show that the trapping is inherently asymmetric with respect to the two (transverse) trapping dimensions. We also present experimental results that show how the sizes of the resultant photorefractive spatial solitons are independent (within their range of existence) of the amplitude of the externally applied electric field used to generate them. C1 CALTECH,PASADENA,CA 91125. UNIV LAQUILA,DIPARTIMENTO FIS,I-67100 LAQUILA,ITALY. USA,RES LAB,FT BELVOIR,VA 22060. FDN UGO BORDONI,ROME,ITALY. RP DUREE, G (reprint author), UNIV ARKANSAS,DEPT PHYS,FAYETTEVILLE,AR 72701, USA. NR 5 TC 82 Z9 82 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD AUG 15 PY 1994 VL 19 IS 16 BP 1195 EP 1197 DI 10.1364/OL.19.001195 PG 3 WC Optics SC Optics GA PA201 UT WOS:A1994PA20100005 PM 19855467 ER PT J AU HENRICKSON, LE GLICK, AJ BRYANT, GW BARBE, DF AF HENRICKSON, LE GLICK, AJ BRYANT, GW BARBE, DF TI NONEQUILIBRIUM-GREENS-FUNCTION THEORY OF TRANSPORT IN INTERACTING QUANTUM DOTS SO PHYSICAL REVIEW B LA English DT Article ID ELECTRON-SYSTEM; OSCILLATIONS; CONDUCTANCE; EQUATION AB We present an approach for modeling nonequilibrium steady-state transport in quantum dots with interacting electrons, which employs real-time many-body Green's functions on a tight-binding basis and accounts for dot-lead coupling exactly. This real-time Green's-function description of transport is used to investigate the steady-state charge-density and current-voltage characteristics of one- and two-dimensional quantum dots having interacting electrons. The quantum dots are composed of a rectangular lattice of tight-binding sites, allowing for multiple degrees of freedom and a spatially varying external electric field. We investigate the effects of both the dot-lead coupling strength and finite current flowing in the dot. Our results indicate that as dot-lead coupling is increased, the Coulomb blockade disappears smoothly; furthermore, the Coulomb blockade may persist even in dots which have tunnel-junction resistances less than h/e(2). We also find that in the Coulomb-blockade regime under conditions of current flow, the assumption of integer steady-state charge on the dot does not necessarily hold true, although the effect of single-electron tunneling does. C1 UNIV MARYLAND,DEPT PHYS,COLLEGE PK,MD 20742. USA,RES LAB,OPT PROCESSING BRANCH,ADELPHI,MD 20783. RP HENRICKSON, LE (reprint author), UNIV MARYLAND,DEPT ELECT ENGN,COLLEGE PK,MD 20742, USA. NR 23 TC 36 Z9 36 U1 0 U2 2 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD AUG 15 PY 1994 VL 50 IS 7 BP 4482 EP 4496 DI 10.1103/PhysRevB.50.4482 PG 15 WC Physics, Condensed Matter SC Physics GA PD753 UT WOS:A1994PD75300027 ER PT J AU KLIMECK, G LAKE, R DATTA, S BRYANT, GW AF KLIMECK, G LAKE, R DATTA, S BRYANT, GW TI ELASTIC AND INELASTIC-SCATTERING IN QUANTUM DOTS IN THE COULOMB-BLOCKADE REGIME SO PHYSICAL REVIEW B LA English DT Article ID RESONANT-TUNNELING STRUCTURES; DEVICE APPLICATIONS; MAGNETIC-FIELD; RATE-EQUATIONS; PHONON PEAK; TRANSPORT; DIODES; NANOSTRUCTURES; BISTABILITY; ELECTRONS AB Starting from a rate-equation model proposed by Beenakker, we calculate current-voltage characteristics for symmetric and asymmetric vertical quantum dots. We include up to 26 electrons and show how single-electron charge interaction, inelastic scattering, and nonadiabatic subband mixing can enhance the valley current significantly by opening new conduction channels. Subband mixing is the dominant mechanism increasing the valley current in both symmetric and asymmetric quantum dots. Single-electron charging is important in asymmetric structures but relatively weak in symmetric structures. Effects of inelastic scattering within the quantum dot are dramatic for asymmetric structures, but negligible in symmetric structures. C1 PURDUE UNIV,SCH ELECT ENGN,W LAFAYETTE,IN 47907. USA,RES LAB,MICROPHOTON DEVICES BRANCH,ADELPHI,MD 20783. RI Klimeck, Gerhard/A-1414-2012 OI Klimeck, Gerhard/0000-0001-7128-773X NR 36 TC 16 Z9 16 U1 0 U2 2 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD AUG 15 PY 1994 VL 50 IS 8 BP 5484 EP 5496 DI 10.1103/PhysRevB.50.5484 PG 13 WC Physics, Condensed Matter SC Physics GA PG283 UT WOS:A1994PG28300053 ER PT J AU WANG, XD KIANG, JG SMALLRIDGE, RC AF WANG, XD KIANG, JG SMALLRIDGE, RC TI A PHOSPHOLIPASE-C INHIBITOR, U-73122, BLOCKS TSH-INDUCED INOSITOL TRISPHOSPHATE PRODUCTION, CA2+ INCREASE AND ARACHIDONIC-ACID RELEASE IN FRTL-5 THYROID-CELLS SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH LA English DT Article DE THYROTROPIN; PHOSPHOLIPASE C; INOSITOL 1,4,5-TRISPHOSPHATE; CALCIUM ION; INTRACELLULAR; ARACHIDONIC ACID; (THYROID CELL); (RAT) ID PROTEIN-KINASE-C; CANINE KIDNEY-CELLS; GROWTH FACTOR-I; ALPHA-1-ADRENERGIC STIMULATION; POLYMORPHONUCLEAR NEUTROPHILS; DEPENDENT PROCESSES; INTRACELLULAR CA2+; CA-2+ MOBILIZATION; IODIDE EFFLUX; THYROTROPIN AB To characterize the role of phospholipase C (FLC)-mediated intrathyroid signal transduction by thyrotropin, we studied the effect of U-73122, an aminosteroid inhibitor of PLC-dependent activity, on TSH-activated PLC-Ca2+ and arachidonic acid (AA) signalling systems in cultured FRTL-5 rat thyroid cells. In the presence of extracellular Ca2+, TSH (0.1 mu M) increased intracellular free calcium concentration ([Ca2+](i)) by 63 +/- 6% with a sustained plateau phase, and AA release by 160 +/- 16%. By deletion of extracellular Ca2+, TSH induced a similar maximal [Ca2+](i) increase, but the plateau phase and AA release were entirely suppressed. U-73122 (5 mu M) inhibited TSH stimulation of H-3-labelled inositol trisphosphates (IP3) production by 73 +/- 3% (P < 0.01) in one study, and completely in another. U-73122 concentration-dependently blocked the TSH-induced Ca2+ increase in either the presence or absence of external Ca2+. U-73122 also showed a similar concentration-response inhibition of TSH-induced AA release. These results provide direct evidence of PLC mediation of TSH-stimulated signal transduction in FRTL-5 thyroid cells. TSH-induced external Ca2+ entry, as well as intracellular Ca2+ mobilization, is probably a PLC-mediated process. From an IP3-sensitive intracellular pool, TSH induces intracellular Ca2+ mobilization. External Ca2+ entry seems to be a prerequisite for TSH-induced AA release. U-73122 inhibition of both cytosolic Ca2+ increase and AA release further confirms [Ca2+](i) dependence for TSH stimulation of AA release. C1 WALTER REED ARMY MED CTR,DEPT CLIN PHYSIOL,DIV MED,WASHINGTON,DC 20307. NR 35 TC 25 Z9 27 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-4889 J9 BBA-MOL CELL RES JI Biochim. Biophys. Acta-Mol. Cell Res. PD AUG 11 PY 1994 VL 1223 IS 1 BP 101 EP 106 DI 10.1016/0167-4889(94)90078-7 PG 6 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA PD311 UT WOS:A1994PD31100013 PM 8061042 ER PT J AU DONOVAN, WH FAMINI, GR AF DONOVAN, WH FAMINI, GR TI AB-INITIO STUDY OF THE ADDITION OF SELECTED FREE-RADICALS TO MONOFLUOROETHYLENE AND 1,1'-DIFLUOROETHYLENE SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID PLESSET PERTURBATION-THEORY; ELECTRON-SPIN-RESONANCE; UNRESTRICTED HARTREE-FOCK; HYPERFINE COUPLING-CONSTANTS; VIBRATIONAL FREQUENCIES; TRANSITION STRUCTURES; SUBSTITUTED OLEFINS; THERMODYNAMIC FUNCTIONS; CORRELATION-ENERGY; HYDROGEN ADDITION AB We report the results of a comprehensive ab initio investigation of the addition reactions of H-., (OH)-O-., (NH2)-N-., and (CH3)-C-. radicals to monofluoroethylene (MFE) and 1,1-difluoroethylene (DFE), considering attack at both carbon atoms. The attack angles of (OH)-O-. and (NH2)-N-. are reduced by including electron correlation at the MP2 level, while those of H-. and (CH3)-C-. remain relatively constant. Reaction barriers, computed up to the PMP4-(SDTQ)/6-311G**//UMP2/6-311G** level, are reduced 5-8 kcal/mol by inclusion of spin projection techniques. This reduction is offset 0-2 kcal/mol by consideration of zero point vibrational energies (ZPVEs). In contrast, heats of reaction are changed by <1 kcal/mol by spin projection but increased 3-6 kcal/mol by ZPVE contributions. The calculated relative reactivities of the four radicals with MFE and DFE agree with experimental data, but discrepancies appear when the predicted regioselectivity of (OH)-O-. and (NH2)-N-. is compared. Although the calculated isotropic hyperfine splitting constants of the radical products are in reasonable accord with experimental data for species with well defined minima, they demonstrate large differences for radicals having greater conformational flexibility. RP DONOVAN, WH (reprint author), USA,EDGEWOOD RES DEV & ENGN CTR,SCBRD RTC,BLDG E3160,ABERDEEN PROVING GROUND,MD 21010, USA. NR 67 TC 14 Z9 14 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD AUG 11 PY 1994 VL 98 IS 32 BP 7811 EP 7818 DI 10.1021/j100083a011 PG 8 WC Chemistry, Physical SC Chemistry GA PC247 UT WOS:A1994PC24700011 ER PT J AU SCHNEIDER, L GEHA, R AF SCHNEIDER, L GEHA, R TI OUTBREAK OF HEPATITIS-C ASSOCIATED WITH INTRAVENOUS IMMUNOGLOBULIN ADMINISTRATION - UNITED-STATES, OCTOBER-1993 JUNE-1994 (REPRINTED FROM MMWR, VOL 43, PG 505-509, 1994) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint ID INFECTION C1 WALTER REED ARMY INST RES,WASHINGTON,DC. US FDA,CTR BIOL EVALUAT & RES,DIV TRANSFUS TRANSMITED DIS,WASHINGTON,DC. US FDA,CTR BIOL EVALUAT & RES,DIV HEMATOL,OFF BLOOD RES & REVIEW,WASHINGTON,DC. NIDDKD,DIV DIGEST DIS & NUTR,BETHESDA,MD. NHLBI,WARREN G MAGNUSON CLIN CTR,DEPT TRANSFUS MED,BETHESDA,MD. CTR DIS CONTROL,NATL CTR INFECT DIS,DIV VIRAL & RICKETTSIAL DIS,ATLANTA,GA. RP SCHNEIDER, L (reprint author), HARVARD UNIV,SCH MED,BOSTON,MA 02115, USA. NR 6 TC 9 Z9 9 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD AUG 10 PY 1994 VL 272 IS 6 BP 424 EP 425 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA PA278 UT WOS:A1994PA27800006 ER PT J AU MASCOLA, JR MCNEIL, JG BURKE, DS AF MASCOLA, JR MCNEIL, JG BURKE, DS TI AIDS VACCINES - ARE WE READY FOR HUMAN EFFICACY TRIALS SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Editorial Material ID FELINE LEUKEMIA-VIRUS; CHIMPANZEES; INFECTION; PROTECTION; HIV-1; GP120 C1 USN,MED RES INST,DEPT INFECT DIS,BETHESDA,MD. RP MASCOLA, JR (reprint author), WALTER REED ARMY INST RES,DIV RETROVIROL,1600 E GUDE DR,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 NR 15 TC 14 Z9 14 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD AUG 10 PY 1994 VL 272 IS 6 BP 488 EP 489 DI 10.1001/jama.272.6.488 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA PA278 UT WOS:A1994PA27800033 PM 8040986 ER PT J AU BURKE, D MASCOLA, J MCNEIL, J MCCUTCHAN, F AF BURKE, D MASCOLA, J MCNEIL, J MCCUTCHAN, F TI INTERNATIONAL HIV STRAINS - 7 GENOTYPES, BUT HOW MANY IMMUNOTYPES SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD AUG PY 1994 VL 10 SU 1 BP S40 EP S40 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA PF066 UT WOS:A1994PF06600081 ER PT J AU FRANCHINI, G GUROFF, M TARTAGLIA, J AGGARAWAL, A ABIMIKU, A MARKHAM, P LIMBACH, K SADOFF, HJ PAOLETTI, E GALLO, RC AF FRANCHINI, G GUROFF, M TARTAGLIA, J AGGARAWAL, A ABIMIKU, A MARKHAM, P LIMBACH, K SADOFF, HJ PAOLETTI, E GALLO, RC TI PRIME/BOOST PROTOCOLS UTILIZING HIGHLY ATTENUATED POXVIRUS VECTORS CONFER PROTECTION AGAINST HIV-2 CHALLENGE SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 NCI,TUMOR CELL BIOL LAB,BETHESDA,MD 20892. VIROGENET CORP,TROY,NY 12180. ADV BIOSCI LABS,KENSINGTON,MD. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD AUG PY 1994 VL 10 SU 1 BP S43 EP S43 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA PF066 UT WOS:A1994PF06600089 ER PT J AU GARTNER, S LIU, YL LEWIS, M POLONIS, V BROWN, C ZACK, P EDDY, G JACKSON, HM AF GARTNER, S LIU, YL LEWIS, M POLONIS, V BROWN, C ZACK, P EDDY, G JACKSON, HM TI DEVELOPMENT OF AN HIV-1 MODEL IN MACAQUES SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 HENRY M JACKSON FDN,ROCKVILLE,MD. WALTER REED ARMY INST RES,WASHINGTON,DC. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD AUG PY 1994 VL 10 SU 1 BP S86 EP S86 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA PF066 UT WOS:A1994PF06600249 ER PT J AU JOSHI, B CHANG, P MAYERS, D LEE, S EPSTEIN, JS HEWLETT, IK AF JOSHI, B CHANG, P MAYERS, D LEE, S EPSTEIN, JS HEWLETT, IK TI INHIBITION OF METHYLATION IN HIV REPLICATION - POTENTIAL USE AS NOVEL ANTI-HIV DRUGS SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 US FDA,CBER,DTTD,BETHESDA,MD. WALTER REED ARMY INST RES,WASHINGTON,DC. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD AUG PY 1994 VL 10 SU 1 BP S24 EP S24 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA PF066 UT WOS:A1994PF06600027 ER PT J AU KAUSHAL, S VANCOTT, T BURKE, DS MOSCA, JD AF KAUSHAL, S VANCOTT, T BURKE, DS MOSCA, JD TI POSSIBLE REQUIREMENT OF ADDITIONAL FACTORS IN ASSOCIATION WITH CD4 BINDING FOR HIV-INFECTION SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 HENRY M JACKSON FDN,ROCKVILLE,MD. WALTER REED ARMY INST RES,ROCKVILLE,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD AUG PY 1994 VL 10 SU 1 BP S72 EP S72 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA PF066 UT WOS:A1994PF06600195 ER PT J AU LOUWAGIE, J MCCUTCHAN, F JANSSENS, W VANDERGROEN, G BURKE, D AF LOUWAGIE, J MCCUTCHAN, F JANSSENS, W VANDERGROEN, G BURKE, D TI PHYLOGENETIC ANALYSIS OF GAG AND ENV GENES FROM INTERNATIONAL HIV-1 ISOLATES AND EVIDENCE FOR MULTIPLE GENOTYPES SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 HENRY M JACKSON FDN RES LAB,ROCKVILLE,MD. INST TROP MED,DIV MICROBIOL,B-2000 ANTWERP,BELGIUM. WALTER REED ARMY INST RES,WASHINGTON,DC. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD AUG PY 1994 VL 10 SU 1 BP S39 EP S39 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA PF066 UT WOS:A1994PF06600075 ER PT J AU REDFIELD, RR AF REDFIELD, RR TI IMMUNE BASED STRATEGIES FOR THE TREATMENT AND PREVENTION OF HIV-INFECTION AND DISEASE SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT RETROVIRAL RES,ROCKVILLE,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD AUG PY 1994 VL 10 SU 1 BP S33 EP S33 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA PF066 UT WOS:A1994PF06600057 ER PT J AU ALLEN, JP LITTEN, RZ ANTON, RF CROSS, GM AF ALLEN, JP LITTEN, RZ ANTON, RF CROSS, GM TI CARBOHYDRATE-DEFICIENT TRANSFERRIN AS A MEASURE OF IMMODERATE DRINKING - REMAINING ISSUES SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Article DE CDT; ANION-EXCHANGE CHROMATOGRAPHY; ISOELECTRIC FOCUSING; SCREENING; BIOCHEMICAL MARKERS ID ANION-EXCHANGE CHROMATOGRAPHY; MITOCHONDRIAL ASPARTATE-AMINOTRANSFERASE; ALCOHOL-CONSUMPTION; DESIALYLATED TRANSFERRIN; SERUM TRANSFERRIN; ABNORMAL MICROHETEROGENEITY; LABORATORY MARKERS; LIVER-DISEASES; HEAVY DRINKING; TF-INDEX AB A growing body of investigations demonstrate that elevated levels of carbohydrate-deficient transferrin (CDT) effectively distinguishes alcoholics recently consuming large amounts of alcohol from light social drinkers or teetotalers. Nevertheless, important questions still remain concerning the value of CDT as a more generalized marker of alcohol consumption. Most important, the nature of the drinking pattern, including quantity and frequency, necessary to raise levels of CDT significantly remains unclear. Neither has research convincingly demonstrated that CDT is as accurate a marker for women, young adults, or non-Caucasian ethnic groups as for White, middle-aged men. Whereas CDT might serve as a useful outcome measure in trials of alcoholism treatment effectiveness, current research suggests that CDT is of limited value in identifying problematic drinking in general medical or community settings in which a broad continuum of drinkers is represented. Combining CDT with other biochemical or self-report screening measures may, however, improve sensitivity in these contexts. At present, the most accurate laboratory technique to detect CDT seems to be isoelectric focusing. Additional research, however, is needed to resolve the issue of whether CDT is best quantitated as a simple value or if its ratio to total transferrin or non-CDT results in higher predictive validity. C1 MED UNIV S CAROLINA,INST PSYCHIAT,COLUMBIA,SC. USA,OFF SURGEON GEN,WASHINGTON,DC 20310. RP ALLEN, JP (reprint author), NIAAA,DIV CLIN & PREVENT RES,TREATMENT RES BRANCH,ROOM 14C-20,5600 FISHERS LANE,ROCKVILLE,MD 20857, USA. NR 60 TC 153 Z9 156 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0145-6008 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD AUG PY 1994 VL 18 IS 4 BP 799 EP 812 DI 10.1111/j.1530-0277.1994.tb00043.x PG 14 WC Substance Abuse SC Substance Abuse GA PC774 UT WOS:A1994PC77400006 PM 7978088 ER PT J AU YAVORSKI, RT SMITH, MA SJOGREN, MH WONG, RKH AF YAVORSKI, RT SMITH, MA SJOGREN, MH WONG, RKH TI RECURRENT CLINICAL EXACERBATIONS OF LIVER-DISEASE DURING THE COURSE OF INFECTION WITH HEPATITIS-C VIRUS SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Note ID RECOMBINANT INTERFERON-ALFA; CHRONIC VIRAL-HEPATITIS; ALPHA-INTERFERON; CONTROLLED TRIAL; THERAPY; RNA; SERUM; FULMINANT AB Symptomatic clinical relapses during the course of chronic hepatitis C virus (HCV) infection are uncommon. Furthermore, acute liver dysfunction with elevated bilirubin during alpha-interferon therapy without other apparent coexisting diagnoses is rare. The case of a 31-yr-old man with three clinical exacerbations of HCV infection over an 18-month period is described. The third episode was characterized by rising serum aminotransferase levels on alpha-interferon therapy. The precise cause of this patient's flares is unknown. An immunologically mediated clearance of the hepatitis C virus, mutation of HCV, or infection with different HCV viral strains are the leading possibilities. RP YAVORSKI, RT (reprint author), WALTER REED ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,WASHINGTON,DC 20307, USA. NR 14 TC 2 Z9 2 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD AUG PY 1994 VL 89 IS 8 BP 1235 EP 1237 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA PB410 UT WOS:A1994PB41000021 PM 8053441 ER PT J AU SMALLRIDGE, RC GIST, ID AF SMALLRIDGE, RC GIST, ID TI P-2-PURINERGIC STIMULATION OF IODIDE EFFLUX IN FRTL-5 RAT-THYROID CELLS INVOLVES PARALLEL ACTIVATION OF PLC AND PLA(2) SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE ADENOSINE 5'-TRIPHOSPHATE; CYTOSOLIC CALCIUM; THYROID; PHOSPHOLIPASE C; PHOSPHOLIPASE A(2); ARACHIDONIC ACID; PROTEIN KINASE C; INOSITOL TRISPHOSPHATE ID SIGNAL TRANSDUCTION SYSTEMS; C-DEPENDENT PROCESSES; CANINE KIDNEY-CELLS; PHOSPHOLIPASE-C; PHOSPHOINOSITIDE TURNOVER; ARACHIDONIC-ACID; POLYMORPHONUCLEAR NEUTROPHILS; SELECTIVE-INHIBITION; INTRACELLULAR CA2+; PERTUSSIS TOXIN AB Extracellular ATP increases inositol phosphates, cytosolic Ca2+ concentration ([Ca2+](i)), arachidonic acid (AA) release, and iodide efflux in FRTL-5 cells. To examine the sequence of events in P-2-purinergic receptor activation by ATP, a phospholipase C (PLC) inhibitor (U-73122) and a phospholipase A(2) (PLA(2)) inhibitor (U-26384), as well as 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA) and downregulation of protein kinase C (PKC) were used. ATP increased inositol trisphosphate (IP3), [Ca2+](i), AA release, and I-125 efflux dose dependently. U-73122 inhibited the IP3 and calcium increase but not AA; U-26384 prevented AA release but not the increase in calcium. Both agents inhibited iodide efflux. BAPTA prevented any ATP-induced increase in [Ca2+](i) without affecting AA release or I-125 efflux. PKC downregulation had no effect on ATP-stimulated AA release, but reduced I-125 efflux. We conclude that ATP-induced iodide efflux involves parallel, not sequential, activation of PLC and PLA(2). No increase in [Ca2+](i) or PKC activity is required for PLA(2) activation In contrast, an increase in I-125 efflux depends on PKC and PLA(2) activities, but not an increase in [Ca2+](i). C1 WALTER REED ARMY MED CTR,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307. RP SMALLRIDGE, RC (reprint author), WALTER REED ARMY MED CTR,DIV MED,WASHINGTON,DC 20307, USA. NR 32 TC 21 Z9 21 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD AUG PY 1994 VL 267 IS 2 BP E323 EP E330 PN 1 PG 8 WC Physiology SC Physiology GA PC439 UT WOS:A1994PC43900056 PM 8074212 ER PT J AU HOFFMAN, RE OATES, E HAFNER, RJ HUSTIG, HH MCGLASHAN, TH AF HOFFMAN, RE OATES, E HAFNER, RJ HUSTIG, HH MCGLASHAN, TH TI SEMANTIC ORGANIZATION OF HALLUCINATED VOICES IN SCHIZOPHRENIA SO AMERICAN JOURNAL OF PSYCHIATRY LA English DT Note AB The authors found that the different hallucinated ''voices'' of four schizophrenic subjects reported over 1-3 weeks expressed semantic content that was at least as persistent as clauses sampled from single 5-7-minute conversational discourses of four comparison speakers. The high degree of semantic recurrence of voices from one day to the next may contribute to the mistaken belief that these experiences derive from a particular nonself agent or speaker. C1 YALE UNIV,SCH MED,DEPT PSYCHIAT,NEW HAVEN,CT. TRIPLER ARMY MED CTR,PSYCHIAT SERV,HONOLULU,HI 96859. GLENSIDE HOSP,DIBDEN RES UNIT,EASTWOOD,SA,AUSTRALIA. NR 7 TC 25 Z9 25 U1 0 U2 0 PU AMER PSYCHIATRIC ASSOCIATION PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 SN 0002-953X J9 AM J PSYCHIAT JI Am. J. Psychiat. PD AUG PY 1994 VL 151 IS 8 BP 1229 EP 1230 PG 2 WC Psychiatry SC Psychiatry GA NZ334 UT WOS:A1994NZ33400024 PM 8037262 ER PT J AU DRABICK, JJ NARAYANAN, RB WILLIAMS, JC LEDUC, JW NACY, CA AF DRABICK, JJ NARAYANAN, RB WILLIAMS, JC LEDUC, JW NACY, CA TI PASSIVE PROTECTION OF MICE AGAINST LETHAL FRANCISELLA-TULARENSIS (LIVE TULAREMIA VACCINE STRAIN) INFECTION BY THE SERA OF HUMAN RECIPIENTS OF THE LIVE TULAREMIA VACCINE SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES LA English DT Article DE TULAREMIA; LIVE VACCINE STRAIN; PASSIVE IMMUNOTHERAPY AB The relative role that humoral immunity plays in protection against infection with the intracellular bacterium, Francisella tularensis, remains controversial. Cellular immunity is thought to play the major and perhaps only role. The authors, in this article, investigate the immunologic and protective properties of immune serum collected from human recipients of the live tularemia vaccine (LVS). Sera of recipients of the vaccine demonstrated reactivity with the vaccine strain by enzyme-linked immunosorbent assay and Western blot analysis. This reactivity appeared to be directed primarily against the lipopolysaccharide of LVS and demonstrated complete cross-reactivity with fully virulent F. tularensis (Schu4). Pooled immune sera protected mice fully against a 10,000 LD50 challenge with the LVS strain relative to nonimmune sera. The protection was abrogated by dilution or preadsorption with the LVS strain but not by preadsorption with Escherichia coli, which suggests specificity of protection. The authors conclude that antibodies to the LVS strain of F. tularensis are generated by live vaccination in humans and play a significant role in protection of mice against lethal challenge with the same organism. These antibodies crossreact completely with fully virulent F. tularensis, but whether they play a role in protection against fully virulent human tularemia strains requires further experimentation. C1 WALTER REED ARMMY INST RES,DEPT CELLULAR IMMUNOL,WASHINGTON,DC. USA,INFECT DIS RES INST,DIV BACTERIOL,INTRACELLULAR PATHOGENS BRANCH,FREDERICK,MD. USA,INFECT DIS RES INST,DIV DIS ASSESSMENT APPL RES,FREDERICK,MD. RP DRABICK, JJ (reprint author), WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307, USA. NR 11 TC 55 Z9 57 U1 0 U2 2 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0002-9629 J9 AM J MED SCI JI Am. J. Med. Sci. PD AUG PY 1994 VL 308 IS 2 BP 83 EP 87 DI 10.1097/00000441-199408000-00003 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA PA658 UT WOS:A1994PA65800003 PM 8042659 ER PT J AU HARTMAN, KR AF HARTMAN, KR TI ANTINEUTROPHIL ANTIBODIES OF THE IMMUNOGLOBULIN-M CLASS IN AUTOIMMUNE NEUTROPENIA SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES LA English DT Article DE NEUTROPENIA; AUTOIMMUNITY; IMMUNOGLOBULINS ID ANTINEUTROPHIL ANTIBODIES; FELTYS SYNDROME AB Anti-neutrophil antibodies of the immunoglobulin G (IgG) class have been implicated in the pathogenesis of autoimmune neutropenia, but few reports have described immunoglobulin M (IgM) anti-neutrophil antibodies. To investigate the prevalence of IgM anti-neutrophil antibodies, sera from 130 patients with possible autoimmune neutropenia were studied for IgG and IgM anti-neutrophil antibodies using an immunofluorescence flow cytometric assay. Twenty-five patients (19%) had IgG anti-neutrophil antibodies exclusively, 21 patients (16%) had both IgG and IgM anti-neutrophil antibodies, and 11 patients (8%) had IgM anti-neutrophil antibodies exclusively. Immunoglobulin M antineutrophil antibodies were found in adults and children with isolated chronic neutropenia and in patients with Felty's syndrome, systemic lupus erythematosus, immune thrombocytopenic purpura, and human immunodeficiency virus. Patients with neutropenia with only IgM antineutrophil antibodies comprised almost 20% of antibody-positive patients in this study. RP HARTMAN, KR (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT HEMATOL,DIV MED,BLDG 40,RM 1073,WASHINGTON,DC 20307, USA. NR 12 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0002-9629 J9 AM J MED SCI JI Am. J. Med. Sci. PD AUG PY 1994 VL 308 IS 2 BP 102 EP 105 DI 10.1097/00000441-199408000-00007 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA PA658 UT WOS:A1994PA65800007 PM 8042648 ER PT J AU STRICKMAN, D TANSKUL, P EAMSILA, C KELLY, DJ AF STRICKMAN, D TANSKUL, P EAMSILA, C KELLY, DJ TI PREVALENCE OF ANTIBODIES TO RICKETTSIAE IN THE HUMAN-POPULATION OF SUBURBAN BANGKOK SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SCRUB TYPHUS; FEBRILE ILLNESS; TSUTSUGAMUSHI; MALAYSIA AB Following a report of three cases of scrub typhus in suburban Bangkok, we performed a serosurvey in the patients' communities. Both IgG and IgM antibodies were measured in an indirect immunoperoxidase assay, using separate spots of antigen from Rickettsia tsutsugamushi (scrub typhus), R. typhi (murine typhus), and TT-118 spotted fever group rickettsiae. Of 215 people donating blood, antibody levels indicative of most recent exposure to R. tsutsugamushi were most prevalent (21%), followed by R. typhi (8%), and TT-118 (4%). Seroprevalence suggesting most recent exposure to R. tsutsuga-mushi varied by location (range 13-31%), gender (26% of females and 13% of males), age (61-80-year-old individuals were the highest, with a prevalence of 38%), and contact with orchards and orchid farms (29% of those with extensive contact, 38% of those with occasional contact, and 10% of those with no contact). These patterns indicated that exposure to R. tsutsugamushi was related to occupation and behavior, as has been observed in areas of rural transmission. Expansion of metropolitan Bangkok has created a situation in which people employed in agriculture live with people employed in the city. As a result, a serosurvey in suburban Bangkok reveals evidence of murine typhus, which is usually transmitted in urban areas, as well as scrub and tick typhus, which are usually transmitted in rural areas. C1 ARMED FORCES RES INST MED SCI, USA MED COMPONENT, DEPT MED ENTOMOL, BANGKOK 10400, THAILAND. ARMED FORCES RES INST MED SCI, ROYAL THAI ARMY COMPONENT, DIV RES, DEPT EPIDEMIOL, BANGKOK 10400, THAILAND. USN, MED RES INST, VIRAL & RICKETTSIAL DIS PROGRAM, BETHESDA, MD USA. NR 26 TC 31 Z9 32 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD AUG PY 1994 VL 51 IS 2 BP 149 EP 153 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA PF850 UT WOS:A1994PF85000003 PM 8074248 ER PT J AU OFULLA, AO ORAGO, AS GITHURE, JI BURANS, JP ALEMAN, GM JOHNSON, AJ MARTIN, SK AF OFULLA, AO ORAGO, AS GITHURE, JI BURANS, JP ALEMAN, GM JOHNSON, AJ MARTIN, SK TI DETERMINATION OF 50 PERCENT INHIBITORY CONCENTRATIONS (IC50) OF ANTIMALARIAL-DRUGS AGAINST PLASMODIUM-FALCIPARUM PARASITES IN A SERUM-FREE MEDIUM SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID INVITRO; SENSITIVITY; CHLOROQUINE AB Plasmodium falciparum chemosensitivity to the various antimalarial drugs is presently determined in the laboratory by setting up multiple microcultures of the parasite and estimating the amount of growth inhibition caused by known concentrations of drug. Parasite growth inhibition is assessed either by microscopy, radiolabeled substrate uptake, or calorimetrically. The obligate requirement for serum in this assay presents difficulties in the direct comparison of results among laboratories. We now have evidence that antimalarial drug sensitivity assays can be reliably performed in a serum-free medium. The overall comparison of 50% inhibitory concentration (IC50) values obtained with serum-free media (bovine albumin, Cohn fraction V [BAM] and BAM combined with glucose and lipids-cholesterol-rich mixture) and those obtained in serum-supplemented medium was r = 0.56; n = 60; P < 0.01. C1 KENYA GOVT MED RES CTR,CLIN RES CTR,NAIROBI,KENYA. KENYATTA UNIV,DEPT ZOOL,NAIROBI,KENYA. USN,MED RES INST,DIV INFECT DIS,BETHESDA,MD 20889. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,USAMRU KENYA,WASHINGTON,DC 20307. RP OFULLA, AO (reprint author), KENYA GOVT MED RES CTR,BIOMED SCI RES CTR,NAIROBI,KENYA. NR 6 TC 6 Z9 6 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD AUG PY 1994 VL 51 IS 2 BP 214 EP 218 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA PF850 UT WOS:A1994PF85000013 PM 8074255 ER PT J AU SITHIPRASASNA, R STRICKMAN, D INNIS, BL LINTHICUM, KJ AF SITHIPRASASNA, R STRICKMAN, D INNIS, BL LINTHICUM, KJ TI ELISA FOR DETECTING DENGUE AND JAPANESE ENCEPHALITIS VIRAL-ANTIGEN IN MOSQUITOS SO ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY LA English DT Article ID POLYMERASE CHAIN-REACTION; MONOCLONAL-ANTIBODIES; IDENTIFICATION; VIRUSES; DETERMINANTS RP SITHIPRASASNA, R (reprint author), ARMED FORCES RES INST MED SCI,DEPT ENTOMOL,315-6 RAJVITHI RD,BANGKOK 10400,THAILAND. NR 25 TC 16 Z9 20 U1 0 U2 1 PU CARFAX PUBL CO PI ABINGDON PA PO BOX 25, ABINGDON, OXFORDSHIRE, ENGLAND OX14 3UE SN 0003-4983 J9 ANN TROP MED PARASIT JI Ann. Trop. Med. Parasitol. PD AUG PY 1994 VL 88 IS 4 BP 397 EP 404 PG 8 WC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine SC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine GA PG207 UT WOS:A1994PG20700007 PM 7979627 ER PT J AU BURRIS, HA AWADA, A KUHN, JG ECKARDT, JR COBB, PW RINALDI, DA FIELDS, S SMITH, L VONHOFF, DD AF BURRIS, HA AWADA, A KUHN, JG ECKARDT, JR COBB, PW RINALDI, DA FIELDS, S SMITH, L VONHOFF, DD TI PHASE-I AND PHARMACOKINETIC STUDIES OF TOPOTECAN ADMINISTERED AS A 72 OR 120-H CONTINUOUS-INFUSION SO ANTI-CANCER DRUGS LA English DT Article DE PHASE-I TRIAL; PHARMACOKINETICS; SOLID TUMORS; TOPOTECAN ID TOPOISOMERASE-I; CAMPTOTHECIN; NSC-100880; TRIAL; DNA AB Topotecan (SK&F 104864-A, NSC 609699) is a water-soluble, semi-synthetic analog of camptothecin which is an inhibitor of topoisomerase I. Since topoisomerase I is cell specific for S phase, we undertook a phase I study to determine the maximum tolerated dose and toxicities of continuous infusion (CI) topotecan. This phase I trial first explored a 5 day CI every 21 day schedule. Doses of topotecan included 0.17, 0.34 and 0.68 mg/m2/day. Fourteen patients [median age 60; median performance status (PS) of 1] with refractory malignancies received 59 courses of drug. Hematologic toxicities occurred only at the highest dose level; NCI grade 3-4 granulocytopenia and thrombocytopenia occurred in 4/8 and 3/8 patients, respectively. The protocol was amended to a 3 day infusion in an effort to ameliorate toxicity and obtain greater dose intensity (DI). Doses of 0.68, 0.85, 1.05, 1.3 and 1.6 mg/m2/day were evaluated. Thirty-two patients (median age 60; median PS of 1) received a total of 115 courses. The major toxicity seen was hematologic with 9/32 and 5/32 patients demonstrating grade 3-4 granulocytopenia and thrombocytopenia, respectively. Non-hematologic toxicities were mild (grade 1-2) in the two schedules and included nausea, vomiting, fatigue and alopecia. At the maximum tolerated dose (MTD) on the 5 day schedule, patients received 0.87 mg/m2/week, whereas they received 1.08 mg/m2/week at the MTD on the 3 day schedule (24% increase in relative dose intensity). A steady-state plasma lactone concentration of 5.5 mg/ml of topotecan was achieved at the phase II recommended dose of 1.6 ng/m2/day as a 3 day continuous infusion. Minor responses were seen in two patients with non-small cell lung cancer and three patients with ovarian cancer. In summary, a greater DI can be achieved with topotecan given on a 3 day schedule than on a 5 day schedule. C1 INST JULES BORDET,SERV MED INTERNE,UNITE CHIMIOTHERAPIE,B-1000 BRUSSELS,BELGIUM. BROOKE ARMY MED CTR,DIV ONCOL,FT SAM HOUSTON,TX 78234. UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. CANC THERAPY & RES CTR S TEXAS,SAN ANTONIO,TX 78229. INST JULES BORDET,H TAGMAN CLIN,INVEST LAB,B-1000 BRUSSELS,BELGIUM. NR 35 TC 42 Z9 42 U1 0 U2 0 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0959-4973 J9 ANTI-CANCER DRUG JI Anti-Cancer Drugs PD AUG PY 1994 VL 5 IS 4 BP 394 EP 402 DI 10.1097/00001813-199408000-00002 PG 9 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA NZ584 UT WOS:A1994NZ58400002 PM 7949242 ER PT J AU BERMAN, J BROWN, L MILLER, R ANDERSEN, SL MCGREEVY, P SCHUSTER, BG ELLIS, W AGER, A ROSSAN, R AF BERMAN, J BROWN, L MILLER, R ANDERSEN, SL MCGREEVY, P SCHUSTER, BG ELLIS, W AGER, A ROSSAN, R TI ANTIMALARIAL ACTIVITY OF WR-243251, A DIHYDROACRIDINEDIONE SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PLASMODIUM-FALCIPARUM; MEFLOQUINE; THAILAND; INVITRO; MALARIA AB WR 243251 is a dihydroacridinedione that was evaluated for antimalarial blood schizonticidal activity in vitro and in vivo. The in vitro doses calculated to kill 50% of organisms were 11 nM for a chloroquine-susceptible, mefloquine-resistant standard strain and 25 nM for a chloroquine- and pyrimethamine-resistant standard strain. The total dose needed to cure 100% of mice infected with a drug-susceptible strain of Plasmodium berghei was 12 to 20 mg/kg of body weight for both oral and subcutaneous administration. The regimen needed to cure 100% of Aotus monkeys infected with Plasmodium falciparum was 8 mg/kg/day for 3 days (chloroquine-susceptible strain) and 16 mg/kg/day for 3 days (chloroquine-resistant strain). The 100% curative doses for Aotus monkeys did not increase for parasites previously exposed to subcurative doses. The absolute value of the curative doses of WR 243251 was comparable to or lower than the values for clinical antimalarial agents. The high absolute activity, comparability of activities against susceptible and resistant parasites, and inability to induce resistance by exposure to subcurative doses suggest that WR 243251 has strong potential as a blood schizonticidal agent. C1 UNIV MIAMI,DEPT MICROBIOL & IMMUNOL,CTR TROP PARASIT DIS,MIAMI,FL 33177. GORGAS MEM LAB,PANAMA CITY,PANAMA. RP BERMAN, J (reprint author), WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 13 TC 18 Z9 18 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD AUG PY 1994 VL 38 IS 8 BP 1753 EP 1756 PG 4 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA NZ449 UT WOS:A1994NZ44900009 PM 7986005 ER PT J AU WESCHE, DL DECOSTER, MA TORTELLA, FC BREWER, TG AF WESCHE, DL DECOSTER, MA TORTELLA, FC BREWER, TG TI NEUROTOXICITY OF ARTEMISININ ANALOGS IN-VITRO SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID ANTIMALARIAL DRUG; CEREBRAL MALARIA; CELL-CULTURE; ARTEMETHER; MEFLOQUINE; ARTEETHER; QINGHAOSU; CHILDREN; INVITRO AB The sesquiterpene endoperoxide antimalarial agents artemether and artemether have been reported to cause neurotoxicity with a discrete distribution in the brain stems of rats and dogs after multiple doses. The nature and distribution of the brain lesions suggest a specific neuronal target, the identity of which is unknown. In order to further investigate artemisinin analog-induced neurotoxicity, we evaluated several in vitro models: fetal rat primary neuronal cultures, fetal rat secondary astrocyte cultures, and transformed neuronal cultures (rat-derived neuroblastoma NG108-15 and mouse-derived neuroblastoma Neuro-2a). Results indicate that toxicity was specific for neuronal cell types but not glial cells. Neurotoxicity, as indexed by liberation of lactate dehydrogenase and/or inhibition of radiolabelled-leucine uptake, was seen in all three neuronal culture types, implicating a common target. In vitro neurotoxicity was dose and time dependent. Acute exposure to drug results in delayed, but not immediate, manifestations of cell toxicity. Structure-activity comparisons indicate that substitutions at positions 9 and 10 and stereoisomerism at position 10 of the artemisinin backbone influence the degree of toxicity. The endoperoxide is necessary but not sufficient for toxicity. Sodium artesunate and dihydroartemisinin, a metabolite common to all artemisinin analogs currently being developed for clinical use, are the most potent of all analogs tested. These results are consistent with a specific neuronal target, but the identity of the target(s) remains unknown. C1 WALTER REED ARMY INST RES,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307. RP WESCHE, DL (reprint author), WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 35 TC 78 Z9 81 U1 1 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD AUG PY 1994 VL 38 IS 8 BP 1813 EP 1819 PG 7 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA NZ449 UT WOS:A1994NZ44900018 PM 7986012 ER PT J AU ANDERSEN, SL AGER, AL MCGREEVY, P SCHUSTER, BG ELLIS, W BERMAN, J AF ANDERSEN, SL AGER, AL MCGREEVY, P SCHUSTER, BG ELLIS, W BERMAN, J TI EFFICACY OF AZITHROMYCIN AS A CAUSAL PROPHYLACTIC AGENT AGAINST MURINE MALARIA SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Note AB The efficacy of the newly marketed azalide azithromycin was compared with that of the clinical agent doxycycline in a murine model of sporozoite-induced malaria. Drug was administered once; Plasmodium yoelii sporozoites were administered 2 h later; survival at day 60 was determined. For parenterally administered drug, 160 mg of azithromycin or doxycycline per kg of body weight was 100% effective; 40 mg of azithromycin per kg was 80% effective, but 40 mg of doxycycline per kg was 40% effective. Orally administered azithromycin was somewhat less effective than parenterally administered drug, consistent with the 37% clinical oral bioavailability of this agent. For orally administered azithromycin, 160 mg/kg was 100% effective and 40 mg/kg was 40% effective. The efficacy of azithromycin in comparison with that of doxycycline and the known prolonged levels of azithromycin in the livers of humans suggest that azithromycin has potential as a clinical causal prophylactic agent for malaria. C1 WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. UNIV MIAMI,CTR TROP PARASIT DIS,DEPT MICROBIOL & IMMUNOL,MIAMI,FL 33177. NR 8 TC 25 Z9 29 U1 1 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD AUG PY 1994 VL 38 IS 8 BP 1862 EP 1863 PG 2 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA NZ449 UT WOS:A1994NZ44900028 PM 7986022 ER PT J AU MEISELMAN, HL HEDDERLEY, D STADDON, SL PIERSON, BJ SYMONDS, CR AF MEISELMAN, HL HEDDERLEY, D STADDON, SL PIERSON, BJ SYMONDS, CR TI EFFECT OF EFFORT ON MEAL SELECTION AND MEAL ACCEPTABILITY IN A STUDENT CAFETERIA SO APPETITE LA English DT Article ID OBESITY AB Past laboratory and field studies show that the effort necessary to obtain food acts as a determinant of food selection and consumption. Two studies examined the impact of increasing the effort needed to obtain candy or potato chips on selection in a normal lunch setting. In the first study, food selection, acceptance and intake were obtained during the first week baseline and under the effort manipulation during the second week. With increased effort, candy selection dropped dramatically in week 2. Subjects substituted items from the dessert, fruit and accessory food groups. In the second study, food selection and acceptance were measured during a 2-week baseline, a 3-week effort period, and a 3-week recovery period. With increased effort, potato chip selection dropped dramatically and only partially recovered in the last phase. Subjects substituted items from the starch food group. These results demonstrate that changes in the effort needed to obtain food can have a nutritional impact in an actual eating situation and could be an important part of a healthy eating strategy. C1 INST FOOD RES,READING,BERKS,ENGLAND. BOURNEMOUTH UNIV,POOLE,ENGLAND. RP MEISELMAN, HL (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 20 TC 23 Z9 23 U1 1 U2 2 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0195-6663 J9 APPETITE JI Appetite PD AUG PY 1994 VL 23 IS 1 BP 43 EP 55 DI 10.1006/appe.1994.1033 PG 13 WC Behavioral Sciences; Nutrition & Dietetics SC Behavioral Sciences; Nutrition & Dietetics GA PK660 UT WOS:A1994PK66000004 PM 7826056 ER PT J AU HEWITT, AD CRAGIN, JH AF HEWITT, AD CRAGIN, JH TI DETERMINATION OF ANION CONCENTRATIONS IN INDIVIDUAL SNOW CRYSTALS AND SNOWFLAKES SO ATMOSPHERIC ENVIRONMENT LA English DT Note DE SNOWFLAKE; ANION CONCENTRATION; CHEMISTRY; CAPILLARY ELECTROPHORESIS ID PARTICLES AB Capillary electrophoresis (CE) was used to measure the concentrations of chloride, sulfate and nitrate in snowflakes and in individual snow crystals. Present handling operations allow analyses to be performed on sample volumes as small as 0.3 mul (e.g. almost-equal-to 1 mm dia. spatial dendrite). Preliminary findings suggest that the anion composition of snowflakes varies both temporally and with crystal habit. RP HEWITT, AD (reprint author), USA, COLD REG RES LAB, HANOVER, NH 03755 USA. NR 17 TC 2 Z9 2 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD AUG PY 1994 VL 28 IS 15 BP 2545 EP 2547 DI 10.1016/1352-2310(94)90404-9 PG 3 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA PH680 UT WOS:A1994PH68000015 ER PT J AU BURROWS, EP AF BURROWS, EP TI DIMETHYL ETHER CHEMICAL-IONIZATION MASS-SPECTROMETRY OF TRICHOTHECENE BIOTOXINS SO BIOLOGICAL MASS SPECTROMETRY LA English DT Article ID ION-MOLECULE REACTIONS; COLLISIONALLY ACTIVATED DISSOCIATION; GAS-CHROMATOGRAPHY; DEOXYNIVALENOL; NIVALENOL; WHEAT AB Dimethyl ether (DME) chemical ionization mass spectrometry with introduction by direct exposure desorption has been utilized for the characterization of a group of 23 structurally diverse biologically active trichothecene toxins. Both proton adducts and a variety of fragment-molecule adduct ions, notably methoxmethylene adducts [M + CH3OCH2](+), resulting from ion-molecule reactions with the reagent gas, were observed. Fragmentation pathways of the proton adducts were documented by collision-induced dissociation (CID) experiments. CID studies of the prominent methoxymethylene adduct ions were also made and were contrasted with those of the corresponding adducts derived from DME-d(6) as reagent gas. RP BURROWS, EP (reprint author), USA,BIOMED RES & DEV LAB,FT DETRICK,FREDERICK,MD 21702, USA. NR 23 TC 10 Z9 10 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 1052-9306 J9 BIOL MASS SPECTROM JI Biol. Mass Spectrom. PD AUG PY 1994 VL 23 IS 8 BP 492 EP 498 DI 10.1002/bms.1200230806 PG 7 WC Biophysics; Spectroscopy SC Biophysics; Spectroscopy GA PA035 UT WOS:A1994PA03500005 ER PT J AU RACINE, CH AF RACINE, CH TI LONG-TERM RECOVERY OF VEGETATION ON 2 EXPERIMENTAL CRUDE-OIL SPILLS IN INTERIOR ALASKA BLACK SPRUCE TAIGA SO CANADIAN JOURNAL OF BOTANY-REVUE CANADIENNE DE BOTANIQUE LA English DT Article DE OIL SPILLS; TAIGA; BLACK SPRUCE; INTERIOR ALASKA; VEGETATION RECOVERY ID NWT; CANADA; NORMAN AB Vegetation was sampled on two black spruce taiga sites in interior Alaska, 15 and 20 years after crude oil was experimentally applied as low-volume sprays or high-volume point spills. Low volume spray spills that uniformly covered the ground caused initial damage to vegetation, but after 20 years recovery of the understory vegetation was almost complete, with dramatic recovery and expansion of fruticose lichens. High-volume point spills created small areas of surface oil saturation with dead vegetation and little sign of recovery but spread out mostly belowground with little or no apparent effect on the shallowly rooted vegetation above even after 15-20 years. Because winter point spills created a much greater area of surface oil, their effects were more damaging. After 15 years on the saturated surface oiled areas, only Eriophorum vaginatum tussocks survive and grow. At both sites with surface oil, black spruce mortality was high, with no evidence of long-term recovery and with continuing chronic effects after 15 years. However, from a long-term perspective the black spruce taiga ecosystem appears to be able to recover from low volume spray spills and to retain large amounts of crude-oil from high-volume point spills belowground with minimal damage to the vegetation. Because of the permafrost, removal of crude oil from this ecosystem by soil excavation is undesirable. In situ acceleration of oil breakdown using fertilizers and bacteria is a possible option; seeding or planting of E. vaginatum on surface-oiled areas may also provide some cover and belowground biomass. RP RACINE, CH (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 22 TC 16 Z9 18 U1 2 U2 10 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0008-4026 J9 CAN J BOT JI Can. J. Bot.-Rev. Can. Bot. PD AUG PY 1994 VL 72 IS 8 BP 1171 EP 1177 PG 7 WC Plant Sciences SC Plant Sciences GA PL960 UT WOS:A1994PL96000012 ER PT J AU KATRITZKY, AR BELYAKOV, SA DURST, HD XU, RX DALAL, NS AF KATRITZKY, AR BELYAKOV, SA DURST, HD XU, RX DALAL, NS TI SYNTHESES OF 3-(SUBSTITUTED)-2,4,6-TRIPHENYLVERDAZYLS SO CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE LA English DT Article ID ORGANIC-REACTIONS; MECHANISM; HYDROXIDE; CATALYST; ETHERS; PHASE AB Two series of 2,4,6-triphenylverdazyls substituted at the C(3) position of the heterocyclic ring are obtained using new convenient synthetic methodology. Thus, crown ether assisted solid-liquid phase-transfer catalysis promotes the formation of 3-n-alkyl-substituted 2,4,6-triphenylverdazyls in the reactions of 1,3,5-triphenylformazan with n-alkyl bromides. Under PTC conditions, methylation of 3-(4-nitrophenyl)-1,5-diphenylformazan with methyl iodide exclusively gives the corresponding verdazyl radical. 3-Substituted 2,4,6-triphenylverdazyls containing various cli(cyclo)alkylaminomethyl]benzotriazoles moieties at the C(3) position of the verdazyl ring are prepared by the reaction of 1,3,5-triphenylformazan with the corresponding 1-[N,N-di(cyclo)alkylaminomethyl]benzotriazoles under the efficient catalysis of barium hydroxide monohydrate. Sonication of this reaction allows the yields of the verdazyls to be substantially increased. A bis-verdazyl N,N-bonded in the C(3) positions was synthesized. All the radicals obtained were characterized by microanalysis, and UV-visible and ESR spectroscopy. C1 USA,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. W VIRGINIA UNIV,MORGANTOWN,WV 26506. RP KATRITZKY, AR (reprint author), UNIV FLORIDA,DEPT CHEM,CTR HETEROCYCL CPDS,GAINESVILLE,FL 32611, USA. NR 25 TC 16 Z9 16 U1 2 U2 4 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0008-4042 J9 CAN J CHEM JI Can. J. Chem.-Rev. Can. Chim. PD AUG PY 1994 VL 72 IS 8 BP 1849 EP 1856 DI 10.1139/v94-235 PG 8 WC Chemistry, Multidisciplinary SC Chemistry GA PE254 UT WOS:A1994PE25400014 ER PT J AU VONHOFF, DD BURRIS, HA ECKARDT, J ROTHENBERG, M FIELDS, SM CHEN, SF KUHN, JG AF VONHOFF, DD BURRIS, HA ECKARDT, J ROTHENBERG, M FIELDS, SM CHEN, SF KUHN, JG TI PRECLINICAL AND PHASE-I TRIALS OF TOPOISOMERASE-I INHIBITORS SO CANCER CHEMOTHERAPY AND PHARMACOLOGY LA English DT Article; Proceedings Paper CT Topoisomerase Inhibitors Conference CY OCT 27-30, 1993 CL MONTEREY, CA SP UNIV MARYLAND CANC CTR DE CPT-11; TOPOTECAN; INTOPLICINE; TOPOISOMERASE I ID INVITRO; TOPOTECAN; ASSAY AB A total of three topoisomerase I inhibitors, including topotecan, CPT-11 (irinotecan), and intoplicine, have been studied in bath preclinical and clinical/clinical pharmacology studies. In in vitro testing against human tumor colony-forming units, all three compounds were significantly more effective when tested as a continuous exposure as compared with a 1-h exposure. The dose-limiting toxicities were different for all three of the agents, with neutropenia and thrombocytopenia being dose-limiting for topotecan; diarrhea, for CPT-11; and hepatotoxicity, for intoplicine. In these phase I studies a number of marginal responses were noted with topotecan; partial and marginal responses, with CPT-11 (particularly in patients with colon cancer); and no response, with in toplicine. The detailed pharmacology of all three agents documented a very short half-life for topotecan, an intermediate half-life for CPT-11, and a prolonged half-life for intoplicine. Based on our experience to date, these compounds (particularly CPT-11) have promise as useful additions to our tremendous therapeutic armamentarium. C1 UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. RP VONHOFF, DD (reprint author), CANC THERAPY & RES CTR S TEXAS,8122 DATAPOINT DR,SUITE 700,SAN ANTONIO,TX 78229, USA. FU NCI NIH HHS [5N01CM 07305] NR 23 TC 21 Z9 21 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0344-5704 J9 CANCER CHEMOTH PHARM JI Cancer Chemother. Pharmacol. PD AUG PY 1994 VL 34 SU S BP S41 EP S45 PG 5 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA PD825 UT WOS:A1994PD82500007 PM 8070026 ER PT J AU CARDELLO, AV AF CARDELLO, AV TI SENSORY-INSTRUMENTAL RESEARCH SO CEREAL FOODS WORLD LA English DT Article RP CARDELLO, AV (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 5 TC 5 Z9 5 U1 0 U2 0 PU AMER ASSOC CEREAL CHEMISTS PI ST PAUL PA 3340 PILOT KNOB RD, ST PAUL, MN 55121-2097 SN 0146-6283 J9 CEREAL FOOD WORLD JI Cereal Foods World PD AUG PY 1994 VL 39 IS 8 BP 567 EP 569 PG 3 WC Food Science & Technology SC Food Science & Technology GA PN335 UT WOS:A1994PN33500006 ER PT J AU GILMAN, JK JALAL, S NACCARELLI, GV AF GILMAN, JK JALAL, S NACCARELLI, GV TI PREDICTING AND PREVENTING SUDDEN-DEATH FROM CARDIAC CAUSES SO CIRCULATION LA English DT Review DE SUDDEN CARDIAC DEATH; VENTRICULAR TACHYCARDIA; VENTRICULAR FIBRILLATION; ANTIARRHYTHMIC DRUGS; IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS ID ACUTE MYOCARDIAL-INFARCTION; COMPLEX VENTRICULAR ARRHYTHMIAS; CONGESTIVE-HEART-FAILURE; CORONARY-ARTERY DISEASE; SIGNAL-AVERAGED ELECTROCARDIOGRAMS; IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR; IDIOPATHIC DILATED CARDIOMYOPATHY; LONG-TERM TREATMENT; HIGH-RISK PATIENTS; FOLLOW-UP AB Sudden cardiac death usually occurs secondary to a ventricular tachyarrhythmia. Even under ideal circumstances only 20% of patients who have an out-of-hospital cardiac arrest survive to hospital discharge. Therefore, aggressive treatment and screening of high-risk patients are mandatory to improve survival rates. Risk stratification of high-risk patients, such as the post-myocardial infarction (MI) population, has been of limited value. Between 70% and 85% of ''high-risk'' post-MI patients, as defined by these screening tests, will not have a sustained ventricular tachyarrhythmia over several years of fellow-up. The use of beta-blockers and possibly amiodarone may have some benefit in reducing mortality in high-risk patients after an MI. Several ongoing trials are studying the use of serial drug testing, amiodarone, and implantable cardioverter-defibrillators in reducing the incidence of sudden cardiac death in patients with potentially lethal ventricular arrhythmias. Although implantable cardioverter-defibrillators appear to be superior to antiarrhythmic drugs in reducing sudden cardiac death, total mortality may not be altered. In sustained ventricular tachyarrhythmias, sotalol and amiodarone appear to be superior to other drugs in preventing arrhythmia recurrence. Ongoing trials, such as the Antiarrhythmic Drug versus Implantable Device (AVID) trial may define the best strategy in these high-risk patients. C1 UNIV TEXAS, SCH MED, DIV CARDIOL, ELECTROPHYSIOL LAB, HOUSTON, TX 77225 USA. BROOKE ARMY MED CTR, SERV CARDIOL, FT SAM HOUSTON, TX 78234 USA. NR 124 TC 39 Z9 39 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0009-7322 EI 1524-4539 J9 CIRCULATION JI Circulation PD AUG PY 1994 VL 90 IS 2 BP 1083 EP 1092 PG 10 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA PA963 UT WOS:A1994PA96300059 PM 7913885 ER PT J AU WILLIAMS, SC PELLER, PJ AF WILLIAMS, SC PELLER, PJ TI GARDNERS-SYNDROME - CASE-REPORT AND DISCUSSION OF THE MANIFESTATIONS OF THE DISORDER SO CLINICAL NUCLEAR MEDICINE LA English DT Note ID FAMILIAL ADENOMATOUS POLYPOSIS; EXTRACOLONIC MANIFESTATIONS; COLI; CANCER AB Extracolonic manifestations of Gardner's syndrome are. common and may precede the detection of colonic polyps. Tc-MDP bone scintigraphy performed on a patient with Gardner's syndrome demonstrated intense uptake of radiotracer within the maxilla and mandible as a result of the dental anomalies associated with this disorder. Nuclear scintigraphy has a role in the imaging of these patients for skeletal anomalies, the detection of thyroid carcinoma, and for skeletal metastases when colon carcinoma is detected. RP WILLIAMS, SC (reprint author), WALTER REED ARMY MED CTR,DEPT RADIOL,NUCL MED SECT,WASHINGTON,DC 20307, USA. NR 13 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD AUG PY 1994 VL 19 IS 8 BP 668 EP 670 DI 10.1097/00003072-199408000-00003 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA PB157 UT WOS:A1994PB15700003 PM 7955741 ER PT J AU MCHALE, KA TENUTA, JJ TOSI, LL MCKAY, DW AF MCHALE, KA TENUTA, JJ TOSI, LL MCKAY, DW TI PERCUTANEOUS INTRAMEDULLARY FIXATION OF LONG-BONE DEFORMITY IN SEVERE OSTEOGENESIS IMPERFECTA SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article AB Reported here are seven patients who had severe osteogenesis imperfecta, and who were extremely fragile, with three having cardiac disease. Their age ranged between 8 and 35 months. All seven patients had unbraceable deformities. Twenty five long bones, including 14 tibiae, 10 femora, and 1 ulna underwent percutaneous intramedullary fixation. Four patients had all four lower extremity long bones operated on simultaneously, Followup was 2 to 11 years. There were no neurologic or vascular complications, compartment syndromes, growth plate problems, or transfusion requirements. All bones heated. One patient had migration of a femoral pin into the knee joint. After bracing, all patients were able to sit; five were able to stand and eventually walk. All living patients were able to be sustained until successful definitive long bone fixation could be accomplished, approximately 2 years or longer after this initial procedure, With this safe, reproducible method, early stable fixation can be provided to patients too young and/or too sick for definitive or extensive open surgery. Future treatment regimens are not compromised. C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,ORTHOPAED SURG SERV,WASHINGTON,DC 20307. CHILDRENS HOSP,DEPT ORTHOPAED SURG,WASHINGTON,DC. CHILDRENS NATL MED CTR,WASHINGTON,DC 20010. NR 9 TC 13 Z9 14 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD AUG PY 1994 IS 305 BP 242 EP 248 PG 7 WC Orthopedics; Surgery SC Orthopedics; Surgery GA PC338 UT WOS:A1994PC33800030 PM 8050236 ER PT J AU BOUTIN, G AF BOUTIN, G TI VIDEO NETWORK SAVES ARMY-CORPS FROM FLOOD OF WORK SO COMMUNICATIONS NEWS LA English DT Article RP BOUTIN, G (reprint author), USA,CORPS ENGINEERS,WASHINGTON,DC, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NELSON PUBLISHING PI NOKOMIS PA 2504 NORTH TAMIAMI TRAIL, NOKOMIS, FL 34275-3482 SN 0010-3632 J9 COMMUN NEWS JI Commun. News PD AUG PY 1994 VL 31 IS 8 BP 38 EP 38 PG 1 WC Telecommunications SC Telecommunications GA PU739 UT WOS:A1994PU73900014 ER PT J AU AZIZ, A LUNARDINI, VJ AF AZIZ, A LUNARDINI, VJ TI ANALYTICAL AND NUMERICAL MODELING OF STEADY PERIODIC HEAT-TRANSFER IN EXTENDED SURFACES SO COMPUTATIONAL MECHANICS LA English DT Article ID BOUNDARY-ELEMENT TECHNIQUE; FINS; TEMPERATURE; STRAIGHT; BASE; FORM AB This paper deals with the analytical and numerical approaches that have been used to study periodic or oscillatory heat transfer processes occurring in extended surfaces. The details pertain to harmonic oscillations but many of the methods can be applied to more general periodic functions. For linear problems, the techniques include complex combination, Laplace transforms, finite differences, and boundary elements. For the nonlinear situations, approaches such as finite differences, finite elments, and different combinations of complex temperature, perturbation, series expansions, straightline, and finite differences have proved effective. Following a brief introduction, the applications of each approach are discussed in detail. Both straight and annular fin configurations are covered and the profile shapes include rectangular, trapezoidal, triangular, and convex parabolic. The periodic conditions involve oscillating base temperature, oscillating base heat flux, oscillating environment temperature, convection at the fin's base through a fluid with oscillating temperature, and some combinations of these conditions. The nonlinear problems discussed cover radiating and convecting-radiating fins, fins with variable thermal conductivity and coordinate dependent heat transfer coefficients, and systems with fin-to-fin, fin-to-base, and fin-to-environment radiative interactions. C1 USA,CRREL,HANOVER,NH 03755. RP AZIZ, A (reprint author), GONZAGA UNIV,SPOKANE,WA 99258, USA. NR 33 TC 4 Z9 4 U1 0 U2 3 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0178-7675 J9 COMPUT MECH JI Comput. Mech. PD AUG PY 1994 VL 14 IS 5 BP 387 EP 410 DI 10.1007/BF00377594 PG 24 WC Mathematics, Interdisciplinary Applications; Mechanics SC Mathematics; Mechanics GA PC719 UT WOS:A1994PC71900002 ER PT J AU LUU, CA AF LUU, CA TI IMPROVED CHELATORS AND SEQUESTRANTS FOR ARMY REVERSE-OSMOSIS WATER-PURIFICATION UNITS (ROWPUS) SO DESALINATION LA English DT Article; Proceedings Paper CT IDA and WRPC World Conference on Desalination and Water Treatment CY NOV 03-06, 1993 CL YOKOHAMA, JAPAN SP INT DESALINAT ASSOC, WATER REUSE PROMOT CTR AB Mobile Reverse Osmosis Water Purification Units (ROWPUs) have been used by the armed forces to provide potable water for field applications. The current water purification systems, consist of the 600 gph, 3000 gph and 150,000 gpd ROWPUs. The ROWPU can provide potable water from any available water source such as fresh, brackish, and seawater and can also purify water that has been contaminated by nuclear, biological and chemical (NBC) warfare agents, The ROWPUs are fielded with certain chemicals that are used to clean the elements and to prevent fouling and scale formation on the membranes, The antiscalant (sodium hexametaphosphate) currently used in the field, is reputed to be an effective antiscalant for constituents typically found in subsurface waters such as silicates of calcium and magnesium, etc., but not necessarily for surface waters containing organic matter, organometallic complexes, or heavy metals. The U.S. Army Belvoir Research, Development and Engineering Center has a contract with Pacific Northwest Laboratory (PNL) to evaluate an effective antiscalant agent that will be effective with multiscalant components and over a wide range of temperatures. The overall development program consists of three phases. The first phase was the market investigation in which 16 potential chemicals were recommended for further evaluation. The second phase of development was the operational analysis which was divided in two stages: 1) bottle screening tests to identify the most promising antiscalants and 2) bench-scale tests in reverse osmosis (RO) membrane test cells to obtain performance data with a test configuration more representative of actual ROWPUs. The final phase of development will be the evaluation of the most promising antiscalants in a single RO element test stand at the Belvoir Research, Development and Engineering Center. This paper presents the results of the second phase tests that were conducted during the operational analysis in which two types of tests were performed. The bottle screening tests were conducted to assess the ability of the antiscalants to inhibit the precipitation of calcium carbonate and calcium sulfate, which are inorganic sealants frequently encountered in water purification and water distribution systems. Based on the results of the Bottle screening studies, the most promising antiscalants were tested in the bench-scale test stand using the flat-plate test cells with view ports to facilitate visual observations with multi-component challenge feed solutions. Permeate flow rates, water conductivities, and visual observations were used to determine the effectiveness of the antiscalants. RP LUU, CA (reprint author), USA,CTR RES DEV & ENGN,SATBE FSE,FT BELVOIR,VA 22060, USA. NR 6 TC 1 Z9 1 U1 1 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0011-9164 J9 DESALINATION JI Desalination PD AUG PY 1994 VL 97 IS 1-3 BP 165 EP 170 DI 10.1016/0011-9164(94)00084-0 PG 6 WC Engineering, Chemical; Water Resources SC Engineering; Water Resources GA PF944 UT WOS:A1994PF94400016 ER PT J AU LARUSSA, VF POLSINELLI, T HOOVER, DL ZHANG, X CUTTING, MA PUTNAK, RJ REID, T AF LARUSSA, VF POLSINELLI, T HOOVER, DL ZHANG, X CUTTING, MA PUTNAK, RJ REID, T TI DIFFERENCES IN VIRUS PROGENY GROWTH OF PARENT AND LIVE-ATTENUATED FORMS OF DENGUE VIRUS AND CYTOKINE PRODUCTION IN STROMAL CELL-CULTURES OF HUMAN MARROW SO EXPERIMENTAL HEMATOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC. GEORGETOWN UNIV,WASHINGTON,DC. NR 0 TC 1 Z9 1 U1 0 U2 0 PU CARDEN JENNINGS PUBL CO LTD PI CHARLOTTESVILLE PA BLAKE CTR, STE 200, 1224 W MAIN ST, CHARLOTTESVILLE, VA 22903 SN 0301-472X J9 EXP HEMATOL JI Exp. Hematol. PD AUG PY 1994 VL 22 IS 8 BP 816 EP 816 PG 1 WC Hematology; Medicine, Research & Experimental SC Hematology; Research & Experimental Medicine GA PB368 UT WOS:A1994PB36800519 ER PT J AU NISHAR, DV SCHIANO, JL PERKINS, WR WEBER, RA AF NISHAR, DV SCHIANO, JL PERKINS, WR WEBER, RA TI ADAPTIVE-CONTROL OF TEMPERATURE IN ARC-WELDING SO IEEE CONTROL SYSTEMS MAGAZINE LA English DT Article C1 PENN STATE UNIV,DEPT ELECT ENGN,UNIVERSITY PK,PA 16802. CUMMINS ENGINE CO,COLUMBUS,IN 47202. UNIV ILLINOIS,COORDINATED SCI LAB,URBANA,IL 61801. USA,CONSTRUCT ENGN RES LABS,CHAMPAIGN,IL 61826. NR 17 TC 4 Z9 4 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0272-1708 J9 IEEE CONTR SYST MAG JI IEEE Control Syst. Mag. PD AUG PY 1994 VL 14 IS 4 BP 4 EP 12 DI 10.1109/37.295964 PG 9 WC Automation & Control Systems SC Automation & Control Systems GA PU937 UT WOS:A1994PU93700003 ER PT J AU KNOP, CM LIBELO, LF AF KNOP, CM LIBELO, LF TI ACHIEVEMENT OF PENCIL-BEAM RADIATION FROM A TM01 MODE CIRCULAR WAVE-GUIDE SOURCE SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Note ID TRANSDUCING ANTENNA AB A method employing appropriately placed parallel-metallic plates in the aperture of a TM01 mode circular waveguide source so as to have it produce pencil-beam radiation is described and analyzed. Programmed computations, with experimental verification, are given for the case of a C-Band TM01 source flared out to a conical horn so as to produce moderate (22 dBi) gain. Means of extending the method to achieve higher gains (40 dBi to 60 dBi) and to modify the plate arrangement so as to produce the same effect with a TE01 mode are briefly outlined. C1 USA,RES LAB,ADELPHI,MD 20783. RP KNOP, CM (reprint author), ANDREW CORP EMRC,ORLAND PK,IL, USA. NR 22 TC 1 Z9 1 U1 1 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD AUG PY 1994 VL 42 IS 8 BP 1188 EP 1192 DI 10.1109/8.310014 PG 5 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA PC495 UT WOS:A1994PC49500020 ER PT J AU AGUILERA, A SINGH, VP MORTON, DC AF AGUILERA, A SINGH, VP MORTON, DC TI ELECTRON-ENERGY DISTRIBUTION AT THE INSULATOR-SEMICONDUCTOR INTERFACE IN AC THIN-FILM ELECTROLUMINESCENT DISPLAY DEVICES SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article ID SIMPLE-MODEL; FIELD AB Electron emission from insulator-semiconductor interface in ZnS:Mn ac thin film electroluminescent (ACTFEL) display devices was investigated by studying the current and field waveforms. A new technique for measuring the interface electron energy distribution at insulator-semiconductor interfaces was developed. The technique involves the measurement of tunnel current transients and can be used to study the interface electron energy distribution between any insulator-semiconductor pair with which an ac thin film test structure can be fabricated. It was applied to a ZnS:Mn display device at two temperatures of 10-degrees-K and 300-degrees-K and to a metal interrace device structure. C1 USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703. RP AGUILERA, A (reprint author), UNIV TEXAS,DEPT ELECT ENGN,EL PASO,TX 79968, USA. NR 20 TC 9 Z9 9 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD AUG PY 1994 VL 41 IS 8 BP 1357 EP 1363 DI 10.1109/16.297730 PG 7 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA PA610 UT WOS:A1994PA61000009 ER PT J AU RHINEHARTJONES, TR FORTIER, AH ELKINS, KL AF RHINEHARTJONES, TR FORTIER, AH ELKINS, KL TI TRANSFER OF IMMUNITY AGAINST LETHAL MURINE FRANCISELLA INFECTION BY SPECIFIC ANTIBODY DEPENDS ON HOST GAMMA-INTERFERON AND T-CELLS SO INFECTION AND IMMUNITY LA English DT Article ID FRANCISELLA-TULARENSIS LVS; POLYMORPHONUCLEAR LEUKOCYTES; PROTECTIVE IMMUNITY; RESISTANCE; GLOBULIN; MICE; MACROPHAGES; DESTRUCTION; GENERATION; ACTIVATION AB Both serum and spleen cells from mice immune to Francisella tularensis transfer protection to naive recipients. Here we characterize the mechanism of protection induced by transfer of immune mouse serum (IMS). IMS obtained 4 weeks after intradermal infection with 10(3) bacteria of the live vaccine strain (LVS) contained high levels of immunoglobulin G2 (IgG2a) and IgM (end point titers, 1:16,600 and 1:7,200, respectively) and little IgG1, IgG2b, or IgG3. LVS-specific antibodies were detected 5 days after intradermal infection, and reached peak levels by 2 weeks postinfection. Only sera obtained 10 days or more after sublethal infection, when IgG titers peaked, transferred protection against a challenge of 100 50% lethal doses (LD(50)s). Purified high-titer IgG anti LVS antibody but not IgM anti-LVS antibody was responsible for transfer of protection against an intraperitoneal challenge of up to 3,000 LD(50)s. IMS had no direct toxic effects on LVS and did not affect uptake or growth of bacteria in association with peritoneal cells. One day after LVS infection, liver, spleen, and lung tissue from mice treated with IMS contained 1 to 2 log units fewer bacteria than did tissue from mice treated with normal mouse serum or phosphate-buffered saline. Between 2 and 4 days after infection, however, bacterial growth rates in tissues were similar in both serum-protected mice and unprotected mice. Bacterial burdens in IMS-treated, LVS-infected mice declined in infected tissues after day 5, whereas control animals died. This lag phase suggested that development of a host response was involved in complete bacterial clearance. In fact, transfer of IMS into normal recipients that were simultaneously treated with anti-gamma interferon and challenged with LVS did not protect mice from death. Further, transfer of IMS into athymic nu/nu mice did not protect against LVS challenge; protection was, however, reconstituted by transfer of normal T cells into nu/nu mice. Thus, ''passive'' transfer of protection against LVS with specific antibody is not passive but depends on a host T cell response to promote clearance of systemic infection and protection against lethal disease. C1 US FDA,CTR BIOL EVALUAT & RES,DIV BACTERIAL PROD,ENTER & SEXUALLY TRANSMITTED DIS LAB,BETHESDA,MD 20852. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT CELLULAR IMMUNOL,ROCKVILLE,MD 20850. NR 35 TC 85 Z9 86 U1 1 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD AUG PY 1994 VL 62 IS 8 BP 3129 EP 3137 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA NY872 UT WOS:A1994NY87200013 PM 8039881 ER PT J AU JETT, M NEILL, R WELCH, C BOYLE, T BERNTON, E HOOVER, D LOWELL, G HUNT, RE CHATTERJEE, S GEMSKI, P AF JETT, M NEILL, R WELCH, C BOYLE, T BERNTON, E HOOVER, D LOWELL, G HUNT, RE CHATTERJEE, S GEMSKI, P TI IDENTIFICATION OF STAPHYLOCOCCAL-ENTEROTOXIN-B SEQUENCES IMPORTANT FOR INDUCTION OF LYMPHOCYTE-PROLIFERATION BY USING SYNTHETIC PEPTIDE-FRAGMENTS OF THE TOXIN SO INFECTION AND IMMUNITY LA English DT Article ID HUMAN PERIPHERAL LYMPHOCYTES; PROTEIN-KINASE-C; T-CELLS; STIMULATORY ACTIVITIES; AUREUS; LOCALIZATION; SUPERANTIGEN; RECEPTOR; SPECIFICITY; ACTIVATION AB A series of 13 synthetic peptides, approximately 30 amino acids each, which spanned the entire sequence of staphylococcal enterotoxin B (SEB) were tested to evaluate their effects on T-cell proliferation in a culture system containing elutriated human peripheral blood lymphocytes incubated with a specific ratio of mononuclear cells. Four peptide regions were found to inhibit SEB-induced proliferation; they included sequences 1 to 30 (previously thought to be involved in major histocompatibility complex class II binding), 61 to 92 (sequences which relate to the T-cell receptor site), 93 to 112 (a linear sequence corresponding to the cysteine loop), and 130 to 160 (containing a highly conserved sequence, KKKVTAQEL). Antisera raised to this last peptide were capable of neutralizing SEB-induced proliferation. Antisera raised against the peptides which overlapped this sequence also were somewhat inhibitory. Neutralizing antisera were not produced from any other peptide sequence tested. To determine if any of these effects were nonspecific with regard to SEB-induced proliferation, the peptides were tested for inhibition of phorbol dibutyryl ester-induced proliferation, and only the sequence 93 to 112 (corresponding to the cysteinyl loop region) was consistently inhibitory (40%). Of the regions which displayed inhibition of SEB-induced proliferation, the peptide 130 to 160 inhibited binding of I-125-SEB to lymphocytes. These data suggest that the resiudes containing and surrounding the sequence KKKVTAQEL may be critical in the SEB-induced proliferation and may be useful for developing neutralizing antisera to SEB. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. JOHNS HOPKINS UNIV,DEPT PEDIAT,BALTIMORE,MD 21205. RP JETT, M (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV PATHOL,WASHINGTON,DC 20307, USA. NR 48 TC 34 Z9 38 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD AUG PY 1994 VL 62 IS 8 BP 3408 EP 3415 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA NY872 UT WOS:A1994NY87200048 PM 8039911 ER PT J AU ELSINGHORST, EA WEITZ, JA AF ELSINGHORST, EA WEITZ, JA TI EPITHELIAL-CELL INVASION AND ADHERENCE DIRECTED BY THE ENTEROTOXIGENIC ESCHERICHIA-COLI TIB LOCUS IS ASSOCIATED WITH A 104-KILODALTON OUTER-MEMBRANE PROTEIN SO INFECTION AND IMMUNITY LA English DT Article ID MAMMALIAN-CELLS; MOLECULAR-CLONING; SHIGELLA-FLEXNERI; DNA FRAGMENTS; GENETIC-LOCUS; HELA-CELLS; EAE GENE; EXPRESSION; COLONIZATION; BACTERIA AB Enterotoxigenic Escherichia coli (ETEC) is capable of invading epithelial cell lines derived from the human colon and ileocecum. Two separate loci (tia and tib) that direct noninvasive E. coli HB101 to adhere to and invade intestinal epithelial cells have previously been cosmid cloned from ETEC H10407. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of cellular fractions from tib-positive HB101 shows that the tib locus directs the synthesis of a 104-kDa outer membrane protein (the TibA protein). The tib locus was subcloned to a maximum of 6.7 kb and mutagenized with transposon Tn5. Production of TibA was directly correlated with the capacity of the subclones and Tn5 mutants to invade and adhere to epithelial cells, suggesting that TibA was required for these phenotypes. The position and direction of transcription of the tibA gene were identified by complementation and in vivo T7 RNA polymerase-promoter induction experiments. The role of the tib locus in epithelial cell invasion was confirmed by the construction of chromosomal deletion derivatives in H10407. These deletion mutants invaded epithelial cells at about 15% of the parental level and were fully complemented by plasmids bearing the tib locus. The size and function of the TibA protein are similar to those of invasin from Yersinia pseudotuberculosis (103 kDa). However, a tib probe did not hybridize with the gene encoding invasin. Hybridization analyses of genomic DNA from a wide variety of pathogenic and nonpathogenic bacteria, including Salmonella, Shigella, Yersinia, and Escherichia species, indicate that the tib locus is unique to specific ETEC strains. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. NR 42 TC 68 Z9 70 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD AUG PY 1994 VL 62 IS 8 BP 3463 EP 3471 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA NY872 UT WOS:A1994NY87200055 PM 8039917 ER PT J AU FORRESTAL, MJ ALTMAN, BS CARGILE, JD HANCHAK, SJ AF FORRESTAL, MJ ALTMAN, BS CARGILE, JD HANCHAK, SJ TI AN EMPIRICAL-EQUATION FOR PENETRATION DEPTH OF OGIVE-NOSE PROJECTILES INTO CONCRETE TARGETS SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article ID RODS AB We conducted depth of penetration experiments with ogive-nose projectiles and concrete targets with unconfined compressive strengths of nominally 14 MPa (2 ksi), 35 MPa (5 ksi), and 97 MPa (14 ksi). From our data and the data presented by Canfield and Clator [J. A. CANFIELD and I. G. CLATOR, Development of a scaling law and techniques to investigate penetration in concrete. NWL Report No. 2057, U.S. Naval Weapons Laboratory, Dahlgren, VA (1966)] [1], we developed an empirical equation for penetration depth of ogive-nose projectiles penetrating concrete targets at normal impact. Our penetration equation contains a single, dimensionless empirical constant that depends only on the unconfined compressive strength of the target. We determine the empirical constant from penetration depth versus striking velocity data with six sets of penetration data for striking velocities between 250 and 800 m/s. Predictions are in good agreement with all six data sets. C1 WATERWAYS EXPT STN,VICKSBURG,MS 39180. UNIV DAYTON,RES INST,DAYTON,OH 45469. RP FORRESTAL, MJ (reprint author), SANDIA NATL LABS,ALBUQUERQUE,NM 87185, USA. NR 5 TC 163 Z9 250 U1 5 U2 42 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD AUG PY 1994 VL 15 IS 4 BP 395 EP 405 DI 10.1016/0734-743X(94)80024-4 PG 11 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA NX410 UT WOS:A1994NX41000006 ER PT J AU RACHELE, H TUNICK, A AF RACHELE, H TUNICK, A TI ENERGY-BALANCE MODEL FOR IMAGERY AND ELECTROMAGNETIC PROPAGATION SO JOURNAL OF APPLIED METEOROLOGY LA English DT Article ID RADIATION AB The character of temperature and moisture gradients in the atmospheric surface layer is shown to be related to the intensity of visual distortions or ''blurring'' of images routinely detected by electo-optical systems and sensors. The authors are able to make quantitative approximations of the optical turbulence effect as represented by the refractive-index structure parameter C(n)2. Through the application of Monin-Obukhov similarity, the magnitudes of potential temperature and specific humidity gradients are determined using values of sensible and latent heat fluxes estimated from a semiempirical radiation and energy balance model. The model is constrained to require a minimum number of conventional meteorological inputs at a specific reference level (i.e., 2 m). These measurements include temperature, pressure, relative humidity, and wind speed. The model also requires a judgment of soil type and moisture (dry, moist, or saturated), cloud characteristics (tenths of cloud cover, opacity, and an estimate of cloud height), day of the year, time of day, and longitude and latitude of the site of interest. Model concepts and equations are presented and several sample results are illustrated. Model estimates of net radiation; sensible, ground, and latent heat fluxes; and C(n)2 are compared with measured values or values derived from measurements. RP USA, RES LAB, BATTLEFIELD ENVIRONM DIRECTORATE, WHITE SANDS MISSILE RANGE, NM 88002 USA. NR 47 TC 11 Z9 12 U1 0 U2 1 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0894-8763 J9 J APPL METEOROL JI J. Appl. Meteorol. PD AUG PY 1994 VL 33 IS 8 BP 964 EP 976 DI 10.1175/1520-0450(1994)033<0964:EBMFIA>2.0.CO;2 PG 13 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA NZ464 UT WOS:A1994NZ46400005 ER PT J AU YEE, E CHAN, R KOSTENIUK, PR CHANDLER, GM BILTOFT, CA BOWERS, JF AF YEE, E CHAN, R KOSTENIUK, PR CHANDLER, GM BILTOFT, CA BOWERS, JF TI EXPERIMENTAL MEASUREMENTS OF CONCENTRATION FLUCTUATIONS AND SCALES IN A DISPERSING PLUME IN THE ATMOSPHERIC SURFACE-LAYER OBTAINED USING A VERY FAST-RESPONSE CONCENTRATION DETECTOR SO JOURNAL OF APPLIED METEOROLOGY LA English DT Article ID BOUNDARY-LAYER; CONCENTRATION STATISTICS; SOURCE SIZE; TURBULENCE; RECURRENCE; DIFFUSION; FIELD; MODEL AB High-frequency fluctuations of concentration in a plume dispersing in the atmospheric surface layer have been measured with high-resolution concentration detectors (approximately 270 Hz at the -6-dB point) to extract various concentration statistics of the fluctuating concentration field. Crosswind and alongwind variations of amplitude statistics (e.g., the total and conditional fluctuation intensity, skewness, and kurtosis), the intermittency factor, and the shapes of the concentration probability density function (PDF) are presented. The behavior of temporal concentration statistics such as the autocorrelation function; power spectrum; PDF of upcrossing intervals; PDF of excursion durations; various concentration timescales, length scales, and microscales (e.g., Taylor microscale, correlation scale, length scale based on the spectral peak, etc.); as well as the velocity-to-concentration timescale ratio are studied. It is shown that all the concentration length scales and microscales (with the exception of the correlation scale) grow with downwind distance in proportion to the mean plume width. C1 KOSTENIUK CONSULTING LTD,SASKATOON,SK,CANADA. S&J ENGN INC,SCARBOROUGH,ON,CANADA. USA,DUGWAY PROVING GROUND,MAT TEST DIRECTORATE,DIV METEOROL,DUGWAY PROVING GROUND,UT. RP YEE, E (reprint author), DEF RES ESTAB SUFFIELD,BOX 4000,MEDICINE HAT T1A 8K6,AB,CANADA. NR 36 TC 49 Z9 50 U1 0 U2 4 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 SN 0894-8763 J9 J APPL METEOROL JI J. Appl. Meteorol. PD AUG PY 1994 VL 33 IS 8 BP 996 EP 1016 DI 10.1175/1520-0450(1994)033<0996:EMOCFA>2.0.CO;2 PG 21 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA NZ464 UT WOS:A1994NZ46400008 ER PT J AU JONES, KA COLE, MW COOKE, P FLEMISH, JR PFEFFER, RL SHEN, H AF JONES, KA COLE, MW COOKE, P FLEMISH, JR PFEFFER, RL SHEN, H TI ACCURATELY DETERMINING THE COMPOSITION AND THICKNESS OF LAYERS IN A GAAS/INGAAS SUPERLATTICE SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID X-RAY-DIFFRACTION; QUANTUM-WELLS; EPITAXY AB The layer thicknesses and composition of molecular beam epitaxy grown four period 200 angstrom/100 angstrom GaAs/InGaAs superlattice structures with nominal indium concentrations of 10%, 15%, and 20% were determined by transmission electron microscopy, Rutherford backscattering spectroscopy, double crystal x-ray diffraction (DXRD), photoreflectance (PR), and photoluminescence (PL). The results show that the indium concentration obtained by DXRD is a little low and that obtained by PR and PL is a little high, and that the discrepancies are larger for the larger indium concentrations. We show that both discrepancies can be accounted for by relaxation of the lattice, elastic relaxation as represented by a radius of curvature, and/or plastic deformation as represented by mismatch of dislocations. For the case of elastic relaxation the tetragonal distortion is less than it would be if the sample were perfectly pseudomorphic. The fractions by which it is reduced for the 10%, 15%, and 20% samples was 0.91, 0.86, and 0.77 as determined by DXRD and 0.80, 0.78, and 0.85 as determined by PR/PL. C1 USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703. NR 14 TC 3 Z9 3 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD AUG 1 PY 1994 VL 76 IS 3 BP 1609 EP 1614 DI 10.1063/1.358461 PG 6 WC Physics, Applied SC Physics GA PA305 UT WOS:A1994PA30500034 ER PT J AU FRIEDL, KE MOORE, RJ MARTINEZLOPEZ, LE VOGEL, JA ASKEW, EW MARCHITELLI, LJ HOYT, RW GORDON, CC AF FRIEDL, KE MOORE, RJ MARTINEZLOPEZ, LE VOGEL, JA ASKEW, EW MARCHITELLI, LJ HOYT, RW GORDON, CC TI LOWER LIMIT OF BODY-FAT IN HEALTHY ACTIVE MEN SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE DENSITOMETRY; ANTHROPOMETRY; WEIGHT REDUCTION; BODY COMPOSITION; ENERGY EXPENDITURE ID X-RAY ABSORPTIOMETRY; DUAL-PHOTON ABSORPTIOMETRY; GENERALIZED LIPODYSTROPHY; SKINFOLD THICKNESS; NUTRITIONAL-STATUS; PHYSICAL-ACTIVITY; DENSITY; TISSUE; WATER; OBESITY AB We examined body composition changes in 55 normal young men during an 8-wk Army combat leadership training course involving strenuous exercise and low energy intake, with an estimated energy deficit of 5.0 +/- 2.0 MJ/day and a resultant 15.7 +/- 3.1% weight loss. Percent body fat (BF) measured by dual-energy X-ray absorptiometry (DEXA) averaged 14.3% (range 6-26%) and 5.8 +/- 1.8% (range 4-11%) at the beginning and end of the course, respectively. Men who achieved a minimum percent BF (4-6%) by 6 wk demonstrated only small additional total and subcutaneous fat losses in the final 2 wk and sacrificed increasingly larger proportions of fat-free mass. Percent BF estimated from skinfold thicknesses reflected relative changes in fat mass, although actual percent BF was overestimated. Instead of reaching a plateau after fat stores were substantially depleted, abdominal, hip, and thigh girths continued to decline with body weight loss. Final percent BF for the leanest men was similar to that observed after a 25% body weight reduction in the 1950 Minnesota study (5.2% by underwater weighing), and height-corrected final fat mass was the same (1.0 +/- 0.2 vs. 0.9 +/- 0.7 kg fat/m(2)), suggesting that these values represent a minimal body fat content in healthy men and that weight loss subsequent to achieving this level is contributed from the fat-free mass. Our results suggest that 4-6% BF or similar to 2.5 kg fat represents the lower limit for healthy men, as assessed by DEXA or by underwater weighing. C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. MARTIN ARMY COMMUNITY HOSP,FT BENNING,GA 31905. OI Friedl, Karl/0000-0002-3134-8427 NR 36 TC 42 Z9 43 U1 0 U2 2 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD AUG PY 1994 VL 77 IS 2 BP 933 EP 940 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA PB787 UT WOS:A1994PB78700061 PM 8002550 ER PT J AU KULESH, DA ANDERSON, LH WILSON, B OTIS, EJ ELGIN, DM BARKER, MJ MEHM, WJ KEARNEY, GP AF KULESH, DA ANDERSON, LH WILSON, B OTIS, EJ ELGIN, DM BARKER, MJ MEHM, WJ KEARNEY, GP TI SPACE-SHUTTLE FLIGHT (STS-45) OF L8 MYOBLAST CELLS RESULTS IN THE ISOLATION OF A NONFUSING CELL-LINE VARIANT SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Article DE MUSCLE; MYOGENESIS; SPACE SHUTTLE; CELL CULTURE; MICROGRAVITY; NEOPLASTIC TRANSFORMATION; CARTRIDGE ID LOOP-HELIX PROTEINS; MUSCLE DEVELOPMENT; GENE-EXPRESSION; MYOD FAMILY; DIFFERENTIATION; GROWTH; TRANSFORMATION; GRAVITY; RAT; MYOGENESIS AB Myoblast cell cultures have been widely employed in conventional (Ig) studies of biological processes because characteristics of intact muscle can be readily observed in these cultured cells. We decided to investigate the effects of spaceflight on muscle by utilizing a well characterized myoblast cell line (L8 rat myoblasts) as cultured in the recently designed Space Tissue Loss Flight Module ''A'' (STL-A). The STL-A is a ''state of the art,'' compact, fully contained, automated cell culture apparatus which replaces a single mid-deck locker on the Space Shuttle, The L8 cells were successfully flown in the STL-A on the Space Shuttle STS-45 mission. Upon return to earth, reculturing of these spaceflown L8 cells (L8SF) resulted in their unexpected failure to fuse and differentiate into myotubes. This inability of the L8SF cells to fuse was found to be a permanent phenotypic alteration. Scanning electron microscopic examination of L8SF cells growing at 1g on fibronectin-coated polypropylene fibers exhibited a strikingly different morphology as compared to control cells. In addition to their failure to fuse into myotubes, L8SF cells also piled up on top of each other. When assayed in fusion-promoting soft agar, L8SF cells gave rise to substantially more and larger colonies than did either preflight (L8AT) or ground control (L8GC) cells. All data to this point indicate that flying L8 rat myoblasts on the Space Shuttle for a duration of 7-10 d at subconfluent densities results in several permanent phenotypic alterations in these cells. (C) 1994 Wiley-Liss, Inc. C1 WALTER REED ARMY MED CTR,DIV SURG,WASHINGTON,DC 20307. TULANE UNIV,SCH MED,NEW ORLEANS,LA 70118. USN ACAD,ANNAPOLIS,MD 21402. RP KULESH, DA (reprint author), USAF,INST PATHOL ANAT,BSC,CPWP,DIV ALTITUDE & HYPERBAR PHYSIOL,WASHINGTON,DC 20306, USA. NR 48 TC 12 Z9 12 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD AUG PY 1994 VL 55 IS 4 BP 530 EP 544 DI 10.1002/jcb.240550412 PG 15 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA PB452 UT WOS:A1994PB45200011 PM 7962182 ER PT J AU LABBATE, LA POLLACK, MH OTTO, MW TESAR, GM ROSENBAUM, JF AF LABBATE, LA POLLACK, MH OTTO, MW TESAR, GM ROSENBAUM, JF TI THE RELATIONSHIP OF ALPRAZOLAM AND CLONAZEPAM DOSE TO STEADY-STATE CONCENTRATION IN PLASMA SO JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY LA English DT Note ID PANIC DISORDER; PHARMACOKINETICS; AGORAPHOBIA; KINETICS AB This report addresses the correlation between dose and concentration of both alprazolam and clonazepam in plasma. Patients were 43 participants in a double-blind, placebo-controlled study of alprazolam and clonazepam for the treatment of panic disorder. The concentration of clonazepam in plasma was linearly related with dose, measured as milligrams per day (R = 0.724; F = 24.2; p = 0.0001) or milligrams per kilogram per day (R = 0.863; F = 58.3; p = 0.0001). The correlation between drug concentration and daily dose of alprazolam was also significant (R = 0.60; F = 9.5; p = 0.007), although the correlation between dose measured as milligrams per kilogram per day and drug level was not significant (R = 0.361; F = 2.4; p = 0.14). This replicates previous findings that, for each additional milligram per day dose of alprazolam, there is a corresponding increase of approximately 10 ng/ml in the plasma and presents preliminary data that, for each added 1 mg/day dose of clonazepam, there is approximately an increase of 12 ng/ml in the plasma. For both drugs, however, there may be considerable variation in level in plasma for a given dose. Weight-adjusted clonazepam concentration may be more predictable than weight-adjusted alprazolam concentration. C1 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,CLIN PSYCHOPHARMACOL UNIT,BOSTON,MA. CLEVELAND CLIN FDN,DEPT PSYCHIAT,CLEVELAND,OH 44195. RP LABBATE, LA (reprint author), WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20307, USA. NR 15 TC 9 Z9 9 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0271-0749 J9 J CLIN PSYCHOPHARM JI J. Clin. Psychopharmacol. PD AUG PY 1994 VL 14 IS 4 BP 274 EP 276 PG 3 WC Pharmacology & Pharmacy; Psychiatry SC Pharmacology & Pharmacy; Psychiatry GA NX836 UT WOS:A1994NX83600008 PM 7962684 ER PT J AU KORIVI, VM TAYLOR, AC NEWMAN, PA HOU, GW JONES, HE AF KORIVI, VM TAYLOR, AC NEWMAN, PA HOU, GW JONES, HE TI AN APPROXIMATELY FACTORED INCREMENTAL STRATEGY FOR CALCULATING CONSISTENT DISCRETE AERODYNAMIC SENSITIVITY DERIVATIVES SO JOURNAL OF COMPUTATIONAL PHYSICS LA English DT Article ID NAVIER-STOKES EQUATIONS; EULER EQUATIONS; OPTIMIZATION; DESIGN AB In this study involving advanced fluid flow codes, an incremental iterative formulation (also known as the ''delta'' or ''correction'' form), together with the well-known spatially split approximate factorization algorithm, is presented for solving the very large sparse systems of linear equations which are associated with aerodynamic sensitivity analysis. For smaller 2D problems a direct method can be applied to solve these linear equations in either the standard or the incremental form, in which case the two are equivalent. Iterative methods are needed for larger 2D and future 3D applications, however, because direct methods require much more computer memory than is currently available. Iterative methods for solving these equations in the standard form are generally unsatisfactory due to a lack of diagonal dominance and perhaps ill-conditioning of the coefficient matrix; this problem can be overcome when these equations are cast in the incremental form. These and other benefits are discussed herein. The methodology is successfully implemented and tested in 2D using an upwind, cell-centered, finite volume formulation applied to the thin-layer Navier-Stokes equations. Results are presented for two sample airfoil problems: (1) subsonic low Reynolds number laminar flow; and (2) transonic high Reynolds number turbulent flow. (C) 1994 Academic Press, Inc. C1 NASA,LANGLEY RES CTR,COMPUTAT SCI BRANCH,HAMPTON,VA 23665. NASA,LANGLEY RES CTR,COMPUTAT SCI BRANCH,USA,AVIAT & TROOP COMMAND,HAMPTON,VA 23665. RP KORIVI, VM (reprint author), OLD DOMINION UNIV,DEPT MECH ENGN,NORFOLK,VA 23529, USA. NR 64 TC 15 Z9 16 U1 0 U2 2 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0021-9991 J9 J COMPUT PHYS JI J. Comput. Phys. PD AUG PY 1994 VL 113 IS 2 BP 336 EP 346 DI 10.1006/jcph.1994.1140 PG 11 WC Computer Science, Interdisciplinary Applications; Physics, Mathematical SC Computer Science; Physics GA NW811 UT WOS:A1994NW81100014 ER PT J AU POLSINELLI, T MELTZER, MS FORTIER, AH AF POLSINELLI, T MELTZER, MS FORTIER, AH TI NITRIC OXIDE-INDEPENDENT KILLING OF FRANCISELLA-TULARENSIS BY IFN-GAMMA-STIMULATED MURINE ALVEOLAR MACROPHAGES SO JOURNAL OF IMMUNOLOGY LA English DT Article ID CHLAMYDIA-PSITTACI REPLICATION; ANTI-MICROBIAL ACTIVITY; LIVE VACCINE STRAIN; INTERFERON-GAMMA; L-ARGININE; INTRACELLULAR MULTIPLICATION; PERITONEAL-MACROPHAGES; LEGIONELLA-PNEUMOPHILA; ANTIMICROBIAL ACTIVITY; OXIDATIVE-METABOLISM AB Alveolar macrophages (AMs) were analyzed for ability to support replication of the intracellular bacterium Francisella tularensis live vaccine strain (LVS). AM supported in vitro growth (2 to 3 logs over 5 days) of LVS with a doubling time of 8 +/- 0.8 h. AMs were analyzed for responsiveness to rIFN-gamma for destruction of this lung pathogen. AM treated with 50 U/ml rIFN-gamma allowed early growth of bacteria (six doublings over 48 h) but between 48 and 96 h rIFN-gamma-treated AM eliminated 1.5 logs of LVS. AMs were sensitive to effects of rIFN-gamma; as little as 5 U/ml rIFN-gamma stimulated AM antimicrobial activity, with half-maximal activity 0.3 U/ml. rIFN-gamma-induced antimicrobial effects in AM correlated with amount of nitrites produced, but nitric oxide played only a minimal role in antibacterial effects induced in AM, because N-G-MMLA (specific inhibitor of L-arginine-dependent nitric oxide production) failed to block antimicrobial activity of IFN-gamma-stimulated AM. IL-10, TGF-beta 1, and IFN-alpha (cytokines known to regulate effector functions of activated macrophages) also did not block anti-F. tularensis activity of IFN-gamma-stimulated AM. Reactive oxygen metabolites, depletion of tryptophan, and sequestration of iron did not contribute to anti-F. tularensis activity because addition of superoxide dismutase or catalase, excess iron, or tryptophan to IFN-gamma-treated AM did not reverse the anti-F. tularensis activity observed in these cells. Regulation of AM effector activity differed from that of other macrophage populations, in that while rIFN-gamma-stimulated AM produced TNF-alpha (100 U/ml at 72 h), TNF-alpha was not required as a costimulator for induction of antimicrobial activities by rIFN-gamma because anti-TNF-alpha treatment of rIFN-gamma-stimulated AM blocked TNF-alpha but had no effect on either production of nitrites or anti-F. tularensis activity. C1 WALTER REED ARMY INST RES,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307. NR 48 TC 70 Z9 71 U1 1 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD AUG 1 PY 1994 VL 153 IS 3 BP 1238 EP 1245 PG 8 WC Immunology SC Immunology GA NY342 UT WOS:A1994NY34200034 PM 8027551 ER PT J AU DUTTA, PK AF DUTTA, PK TI LOW-TEMPERATURE COMPRESSIVE STRENGTH OF GLASS-FIBER-REINFORCED POLYMER COMPOSITES SO JOURNAL OF OFFSHORE MECHANICS AND ARCTIC ENGINEERING-TRANSACTIONS OF THE ASME LA English DT Article AB Polymeric composites are relatively inexpensive materials of high strength, in which deformation of the matrix is used to transfer stress by means of shear traction at the fiber-matrix interface to the embedded high-strength fibers. At low temperatures, complex stresses are set up within the microstructure of the material as a result of matrix stiffening and mismatch of thermal expansion coefficients of the constituents of the composites. These stresses in turn affect the strength and deformation characteristics of the composites. This is demonstrated by compression testing of an unidirectional glass-fiber-reinforced polymer composite at room and low temperatures. The increase of compressive strength matched the analytical prediction of strength increase modeled from the consideration of increase in matrix stiffness and thermal residual stresses at low temperatures. Additional compression tests performed on a batch of low-temperature thermally cycled specimens confirmed the predictable reduction of brittleness due to suspected increase of microcrack density. The mode of failure characterized by definite pre-fracture yielding conforms more to Budiansky's plastic microbuckling theory than to Rosen's theory of elastic shear or extensional buckling. RP DUTTA, PK (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 10 TC 17 Z9 17 U1 0 U2 1 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0892-7219 J9 J OFFSHORE MECH ARCT JI J. Offshore Mech. Arct. Eng. Trans. ASME PD AUG PY 1994 VL 116 IS 3 BP 167 EP 172 DI 10.1115/1.2920146 PG 6 WC Engineering, Ocean; Engineering, Mechanical SC Engineering GA PT542 UT WOS:A1994PT54200008 ER PT J AU FITZPATRICK, JC CIOFFI, WG CHEU, HW PRUITT, BA AF FITZPATRICK, JC CIOFFI, WG CHEU, HW PRUITT, BA TI PREDICTING VENTILATION FAILURE IN CHILDREN WITH INHALATION INJURY SO JOURNAL OF PEDIATRIC SURGERY LA English DT Article; Proceedings Paper CT 1993 Annual Meeting of the Section on Surgery of the American-Academy-of-Pediatrics CY OCT 29-31, 1993 CL WASHINGTON, DC SP AMER ACAD PEDIAT DE VENTILATION FAILURE PREDICTOR; INHALATION INJURY; CHILDREN ID FREQUENCY OSCILLATORY VENTILATION; LUNG INJURY; PERCUSSIVE VENTILATION; MECHANICAL VENTILATION C1 WILFORD HALL USAF MED CTR,SAN ANTONIO,TX 78236. RP FITZPATRICK, JC (reprint author), USA,INST SURG RES,SGRD-USC-B,2322 HARNEY RD,FT SAM HOUSTON,TX 78234, USA. NR 13 TC 18 Z9 18 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0022-3468 J9 J PEDIATR SURG JI J. Pediatr. Surg. PD AUG PY 1994 VL 29 IS 8 BP 1122 EP 1126 DI 10.1016/0022-3468(94)90292-5 PG 5 WC Pediatrics; Surgery SC Pediatrics; Surgery GA PB516 UT WOS:A1994PB51600035 PM 7965518 ER PT J AU SIMON, GA SCHMID, P REIFENRATH, WG VANRAVENSWAAY, T STUCK, BE AF SIMON, GA SCHMID, P REIFENRATH, WG VANRAVENSWAAY, T STUCK, BE TI WOUND-HEALING AFTER LASER INJURY TO SKIN - THE EFFECT OF OCCLUSION AND VITAMIN-E SO JOURNAL OF PHARMACEUTICAL SCIENCES LA English DT Article ID PORT-WINE STAINS; CARBON-DIOXIDE AB The skin of Yorkshire pigs was irradiated with various doses of argon and copper-vapor laser and evaluated for effects on healing time of pretreatment with topical or intramuscular vitamin E or the Op-Site wound dressing. Incident irradiance for both lasers was between 3.5 and 4.5 W/cm(2) for a 10-14-mm beam diameter with a nearly uniform intensity profile. Minimal erythemic dose for the copper-vapor laser was 35 +/- 2 J/cm(2) (10 s exposure) and 22.4 +/- 0.1 J/cm(2) (6-s exposure) for the argon laser. Three dose levels were administered: a low dose causing light erythema, an intermediate dose, and a high dose causing dermal stasis. The radiant exposures far low, intermediate, and high doses were 35, 70, and 138 J/cm(2) for the copper-vapor laser and 22.4, 55, and 129 J/cm(2) for the argon laser. Exposure to argon and copper-vapor lasers generally caused wounds with similar healing times. Healing time was significantly decreased for wounds caused by intermediate exposure of the copper-vapor laser and either pretreated with vitamin E or treated with the wound dressing. Healing times for corresponding argon-laser exposure were significantly decreased with pretreatment of intramuscular vitamin E only or after treatment with the wound dressing. These findings may be valuable in selecting treatment for accidental laser skin injuries in man. C1 ISRAEL INST BIOL RES,IL-70450 NESS ZIONA,ISRAEL. LETTERMAN ARMY INST RES,SAN FRANCISCO,CA 94129. USA,MED RES DETATCHMENT,WALTER REED ARMY INST RES,BROOKS AFB,TX 78235. RP SIMON, GA (reprint author), REIFENRATH CONSULTING & RES,NOVATO,CA 94948, USA. NR 20 TC 11 Z9 13 U1 1 U2 2 PU AMER PHARMACEUTICAL ASSN PI WASHINGTON PA 2215 CONSTITUTION AVE NW, WASHINGTON, DC 20037 SN 0022-3549 J9 J PHARM SCI JI J. Pharm. Sci. PD AUG PY 1994 VL 83 IS 8 BP 1101 EP 1106 DI 10.1002/jps.2600830807 PG 6 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Pharmacology & Pharmacy; Chemistry GA PA985 UT WOS:A1994PA98500005 PM 7983592 ER PT J AU NELSON, DR VONGONTEN, AS AF NELSON, DR VONGONTEN, AS TI BIOMECHANICAL AND AESTHETIC CONSIDERATIONS FOR MAXILLARY ANTERIOR OVERDENTURE ABUTMENT SELECTION SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID COMPLETE DENTURE AB Maxillary canine teeth traditionally have been selected as overdenture abutments. Undesirable aspects associated with the use of maxillary canines as overdenture abutments are described. The use of maxillary lateral incisors as overdenture abutments offers vertical support to the prosthesis, favorable stress distribution, improved esthetics, and preservation of the premaxilla. C1 USA,DENT ACT,COMBINED PROSTHODONT PROGRAM,FT BLISS,TX. RP NELSON, DR (reprint author), MED UNIV S CAROLINA,COLL DENT MED,DEPT PROSTHODONT,DIV REMOVABLE PROSTHODONT,171 ASHLEY AVE,CHARLESTON,SC 29425, USA. NR 9 TC 0 Z9 0 U1 0 U2 2 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD AUG PY 1994 VL 72 IS 2 BP 133 EP 136 DI 10.1016/0022-3913(94)90069-8 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA NZ996 UT WOS:A1994NZ99600003 PM 7932257 ER PT J AU TRAKIMAS, C SPERLING, LC SKELTON, HG SMITH, KJ BUKER, JL AF TRAKIMAS, C SPERLING, LC SKELTON, HG SMITH, KJ BUKER, JL TI CLINICAL AND HISTOLOGIC-FINDINGS IN TEMPORAL TRIANGULAR ALOPECIA SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID ANATOMY; SCALP AB Background: Temporal triangular alopecia (TTA; also called ''congenital triangular alopecia'') is a common disorder that is assumed to be congenital. Little is known about its histologic features. Objective: Our purpose was to describe four new cases, review the literature, and present histologic features based on vertical and transverse sectioning. Methods: The history, clinical features, and histologic findings of four patients with TTA are described and the relevant literature reviewed. Results: Lesions of TTA are seldom congenital, and most are best described as lancet-shaped. The ''bald spot'' contains normal numbers of hairs, although virtually all are vellus or indeterminate follicles. Conclusion: Most cases of TTA appear to develop during the first few years of life, and the designation ''congenital'' is a misnomer. The appearance of alopecia can be best explained as a focal zone of hair miniaturization leading to vellus hair formation. C1 WALTER REED ARMY MED CTR, DERMATOL SERV, WASHINGTON, DC 20307 USA. ARMED FORCES INST PATHOL, DERMATOPATHOL BRANCH, WASHINGTON, DC 20306 USA. WALTER REED ARMY INST RES, WASHINGTON, DC USA. NATL NAVAL MED CTR, DERMATOL SERV, BETHESDA, MD USA. NR 23 TC 32 Z9 33 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD AUG PY 1994 VL 31 IS 2 BP 205 EP 209 PN 1 PG 5 WC Dermatology SC Dermatology GA NZ589 UT WOS:A1994NZ58900005 PM 8040402 ER PT J AU KRIVDA, SJ BENSON, PM AF KRIVDA, SJ BENSON, PM TI NONPIGMENTING FIXED DRUG ERUPTION SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Note RP KRIVDA, SJ (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 7 TC 12 Z9 12 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD AUG PY 1994 VL 31 IS 2 BP 291 EP 292 PN 1 PG 2 WC Dermatology SC Dermatology GA NZ589 UT WOS:A1994NZ58900029 PM 8040423 ER PT J AU SMITH, KJ SKELTON, HM VOGEL, P YEAGER, J BAXTER, D WAGNER, KF AF SMITH, KJ SKELTON, HM VOGEL, P YEAGER, J BAXTER, D WAGNER, KF TI LYMPHOCYTE POPULATIONS ASSOCIATED WITH EXAGGERATED INSECT BITE REACTION - REPLY SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Letter ID DELTA-T-CELLS; HIV-1 INFECTION C1 WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. NATL NAVAL MED CTR, BETHESDA, MD USA. HENRY M JACKSON FDN, BETHESDA, MD USA. RP SMITH, KJ (reprint author), WALTER REED ARMY INST RES, WASHINGTON, DC USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD AUG PY 1994 VL 31 IS 2 BP 298 EP 299 PN 1 PG 2 WC Dermatology SC Dermatology GA NZ589 UT WOS:A1994NZ58900037 ER PT J AU PALMER, WG ANDREWS, AW MELLINI, D TERRA, JA HOFFMANN, FJ HOKE, SH AF PALMER, WG ANDREWS, AW MELLINI, D TERRA, JA HOFFMANN, FJ HOKE, SH TI MUTAGENICITY OF PARTICULATE-EMISSIONS FROM THE M16 RIFLE - VARIATION WITH PARTICLE-SIZE SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH LA English DT Article ID FLY-ASH; HYDROCARBONS AB Emissions generated by firing the M16 rifle with the propellant WC844 in a combustion chamber designed to simulate conditions of actual use were tested for mutagenic activity in the Salmonella/Ames assay. Dimethyl sulfoxide extracts of emissions collected from either the breech or muzzle end of the rifle were mutagenic in three strains of Salmonella (TA1537, TA1538, and TA98) both in the presence and absence of metabolic activation systems (S9). The extracts were negative in strains TA100 and TA102. Aerosols generated by firing the M16 rifle were fractionated according to aerodynamic diameter. Submicrometer particles were far more mutagenic than particles with aerodynamic diameters between 1 and 15 mu m. The mutagens associated with the smaller particles were more active in the presence of S9, while extracts of larger particles were as active, or more active, in the absence of S9. Heavier particles, which settled rapidly out of the airstream, were not mutagenic. C1 NCI,FREDERICK CANC RES & DEV CTR,PRI DYNCORP,FREDERICK,MD 21702. RP PALMER, WG (reprint author), USA,BIOMED RES & DEV LAB,BLDG 568,FT DETRICK,FREDERICK,MD 21702, USA. RI Hoke, Robert/F-4943-2010 NR 15 TC 2 Z9 2 U1 0 U2 1 PU TAYLOR & FRANCIS PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 0098-4108 J9 J TOXICOL ENV HEALTH JI J. Toxicol. Environ. Health PD AUG PY 1994 VL 42 IS 4 BP 423 EP 433 PG 11 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA PB413 UT WOS:A1994PB41300005 PM 8051716 ER PT J AU MILNER, EA CIOFFI, WG MASON, AD MCMANUS, WF PRUITT, BA AF MILNER, EA CIOFFI, WG MASON, AD MCMANUS, WF PRUITT, BA TI A LONGITUDINAL-STUDY OF RESTING ENERGY-EXPENDITURE IN THERMALLY INJURED PATIENTS SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article ID BURNED PATIENTS; REQUIREMENTS; EXCISION AB We have recently developed a new burn-specific equation that satisfactorily estimates initial caloric requirements for thermally injured patients. In the present study, we compared these estimates with resting energy expenditures (REE) (n = 141) measured weekly by indirect calorimetry in 20 patients between postburn days 3 and 348. In this group, mean initial burn size was 46.7% (range, 21-88) and mean age 31.3 years (range, 19-61). Serial measurements were continued until the burn wounds were closed or the patient was discharged. Multiple regression analysis indicated a relationship between REE, initial burn size, and postburn day in these patients (r = 0.65). This analysis indicated a general trend of decline in REE toward normal values 100 to 150 days postburn in patients with smaller burns (20%-40%) and roughly 250 days postinjury in those with larger burns (>75%). The initial predictive equation appeared adequate for estimating caloric needs during the first postburn month, but beyond 30 days postburn indirect calorimetric measurements became necessary for accurate estimation of caloric requirements. RP MILNER, EA (reprint author), USA,INST SURG RES,FT SAM HOUSTON,TX 78234, USA. NR 11 TC 42 Z9 42 U1 1 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD AUG PY 1994 VL 37 IS 2 BP 167 EP 170 DI 10.1097/00005373-199408000-00001 PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA PC952 UT WOS:A1994PC95200001 PM 8064909 ER PT J AU OGURA, H CIOFFI, WG JORDAN, BS OKERBERG, CV JOHNSON, AA MASON, AD PRUITT, BA AF OGURA, H CIOFFI, WG JORDAN, BS OKERBERG, CV JOHNSON, AA MASON, AD PRUITT, BA TI THE EFFECT OF INHALED NITRIC-OXIDE ON SMOKE-INHALATION INJURY IN AN OVINE MODEL SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article ID SELECTIVE PULMONARY VASODILATOR; L-ARGININE; SHEEP; VASOCONSTRICTION; HYPERTENSION; PHYSIOLOGY; PNEUMONIA; OCCLUSION; INVITRO; SHOCK AB Smoke inhalation is a significant comorbid factor in thermal trauma. The effect of inhaled nitric oxide (NO) on smoke inhalation injury was evaluated in an ovine model. Following smoke exposure, group 1 animals (n = 9) spontaneously breathed room air, and group 2 animals (n = 8) breathed 20 parts per million of NO in air for 48 hours. Cardiopulmonary variables and blood gases were serially measured; bronchoalveolar lavage (BAL) was performed and wet-to-dry lung weight ratios (W/D) determined at 48 hours. Pulmonary vasoconstriction following smoke inhalation was significantly attenuated by inhaled NO (p < 0.05), which exerted no apparent effect on the systemic circulation. In group 2, the serial decline in pulmonary oxygenation was less than in group 1, consistent with a smaller physiologic shunt (p < 0.05). There were no significant differences in W/D, lung compliance, BAL fluid analysis results, or histologic evaluation findings between the two groups. These results suggest that inhaled NO exerted beneficial effects on pulmonary arterial hypertension and oxygenation following smoke inhalation without apparent amelioration of airway inflammation. C1 USA, INST SURG RES, FT SAM HOUSTON, TX 78234 USA. NR 40 TC 28 Z9 29 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD AUG PY 1994 VL 37 IS 2 BP 294 EP 302 DI 10.1097/00005373-199408000-00023 PG 9 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA PC952 UT WOS:A1994PC95200023 PM 8064931 ER PT J AU LEWIS, DJ SESTERHENN, IA MCCARTHY, WF MOUL, JW AF LEWIS, DJ SESTERHENN, IA MCCARTHY, WF MOUL, JW TI IMMUNOHISTOCHEMICAL EXPRESSION OF P53 TUMOR-SUPPRESSOR GENE PROTEIN IN ADULT GERM-CELL TESTIS TUMORS - CLINICAL CORRELATION IN STAGE-I DISEASE SO JOURNAL OF UROLOGY LA English DT Article DE TESTICULAR NEOPLASMS; SEMINOMA; IMMUNOHISTOCHEMISTRY; NEOPLASM STAGING; PROTEIN P53 ID TESTICULAR CANCER INTERGROUP; LUNG-CANCER; COMMON FEATURE; MUTANT P53; MUTATIONS; CARCINOMA; PROGNOSIS; NEOPLASIA; ONCOGENE; BLADDER AB P53 tumor suppressor gene protein immunostaining was evaluated in the primary tumor of adult testicular germ cell cancer to assess if P53 expression would serve as a clinically useful tumor marker. Representative archival tissues from 152 orchiectomy specimens were studied for P53 immunohistochemistry. Seminoma and nonseminomatous germ cell tumor constituents revealed P53 expression via immunohistochemistry in 90% and 94% of the cases, respectively. For seminoma, there was a trend toward decreased P53 expression with advancing stage. For nonseminomatous germ cell tumor, although all cellular components showed variable P53 expression, P53 expression in embryonal carcinoma constituents increased among stages of disease. A third of pathological stage I cancer patients exhibited 2+ or greater P53-embryonal staining compared with 61% with stage II (p = 0.0670) and 67% with stage III (p = 0.0815) disease, respectively (Kruskal-Wallis, 2-sided test). As a secondary objective, we wanted to determine if P53 immunohistochemistry would be useful to predict occult disease in clinical stage I nonseminomatous germ cell tumor. This group was studied for P53-embryonal immunohistochemistry, the presence of vascular invasion and the quantitative determination of percentage of embryonal carcinoma in the primary tumor in a multivariate fashion to assess if these tests could be clinically useful to predict occult disease. Degree of P53 immunostaining of the embryonal component in the primary tumor was statistically greater for stage II by univariate logistic regression analysis (p = 0.0362). Similarly, the per cent embryonal cancer (p = 0.0002) and vascular invasion (p = 0.0005) were highly significant as predictors of occult stage II disease via the univariate testing. By multivariate logistic regression analysis, the model consisting of per cent embryonal cancer and vascular invasion provided the best prediction of occult disease in the clinical stage I cohort. In addition, this model had the highest sensitivity and specificity of all multivariate models considered. The addition of P53-embryonal staining did not improve predictability nor sensitivity/specificity. The P53 tumor suppressor gene protein is expressed to some degree in most testicular germ cell tumors and degree of staining/expression varies according to stage of disease. From the standpoint of a clinically useful primary tumor risk factor for predicting occult disease, vascular invasion by the tumor and percentage of embryonal carcinoma component in the tumor are more useful than P53 immunohistochemistry. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT SURG & CLIN INVEST,UROL SERV,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,DEPT GENITOURINARY PATHOL,WASHINGTON,DC. NR 39 TC 49 Z9 49 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD AUG PY 1994 VL 152 IS 2 BP 418 EP 423 PN 1 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA NW329 UT WOS:A1994NW32900031 PM 8015085 ER PT J AU SILS, IV SZLYKMODROW, PC TARTARINI, KA HUBBARD, LJ GLASS, E CARETTI, DM DARRIGRAND, AK AF SILS, IV SZLYKMODROW, PC TARTARINI, KA HUBBARD, LJ GLASS, E CARETTI, DM DARRIGRAND, AK TI CHRONIC IMPLANTATION OF NONOCCLUSIVE CATHETERS AND FLOW PROBES IN THE SPLANCHNIC AND HINDLIMB VASCULATURE OF THE RABBIT SO LABORATORY ANIMAL SCIENCE LA English DT Article ID BLOOD-FLOW; CARDIAC-OUTPUT; CONSCIOUS RATS; VALIDATION; VEIN; HEAT AB Flow probes and nonocclusive catheters were simultaneously implanted in the splanchnic and hindlimb vasculature to measure regional blood flows and arteriovenous differences of individual organs in the conscious rabbit. Pulsed Doppler flow probes were constructed by modifying the technique of Haywood et al., and nonocclusive catheters were designed and constructed from Silastic tubing (0.6- or 0.9-mm OD) and surgical velour. Laparotomy was performed on rabbits under anesthesia, and the renal, mesenteric, iliac, or hepatic artery and portal vein were isolated and instrumented with a flow probe. A nonocclusive catheter was then inserted into the respective vein. Instrumentation of the hepatic system required probes on the hepatic artery and portal vein, and nonocclusive catheters were placed into hepatic and portal veins. One week later, rabbits were reanesthetized and nonocclusive catheters were inserted into the cranial vena cava via the jugular vein and abdominal aorta to the level of the celiac axis. Probes and catheters were evaluated daily up to 30 days. Implants remained functional for an average of 3 weeks, permitting chronic measurement of velocity and blood variables in individual tissue beds of the conscious rabbit. RP SILS, IV (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 27 TC 3 Z9 3 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD AUG PY 1994 VL 44 IS 4 BP 319 EP 325 PG 7 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA PD469 UT WOS:A1994PD46900004 PM 7983841 ER PT J AU BARTH, J AF BARTH, J TI MUNICIPAL BOND PORTFOLIO MANAGEMENT - FABOZZI,FJ SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD AUG PY 1994 VL 119 IS 13 BP 98 EP 98 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA PB525 UT WOS:A1994PB52500178 ER PT J AU EBERT, TA SCHROETER, SC DIXON, JD KALVASS, P AF EBERT, TA SCHROETER, SC DIXON, JD KALVASS, P TI SETTLEMENT-PATTERNS OF RED AND PURPLE SEA-URCHINS (STRONGYLOCENTROTUS-FRANCISCANUS AND STRONGYLOCENTROTUS-PURPURATUS) IN CALIFORNIA, USA SO MARINE ECOLOGY PROGRESS SERIES LA English DT Article DE ECHINODERMATA; ECHINOIDEA; SEA URCHIN; SETTLEMENT ID NORTHERN CALIFORNIA; KELP FOREST; EL-NINO; RECRUITMENT; MORTALITY; GROWTH; LARVAE; POPULATIONS; ECHINOIDS; DISPERSAL AB Weekly settlement of red and purple sea urchins (Strongylocentrotus franciscanus and S. purpuratus) was documented at sites in northern and southern California (USA) for 4 settlement seasons from 1990 to 1993. Newly settled sea urchins (<0.5 mm) were collected from standardized settlement surfaces (scrub brushes), identified and counted, There was marked seasonality in settlement. For both species, most settlement occurred during one to several episodes between February and July of each year. Settlement tended to be more regularly annual in southern than in northern California and settlement densities generally were higher in the south. This pattern is consistent with greater retention of water in the Southern California Bight and more energetic offshore advection of water in northern California, S. purpuratus showed geographic coherence in settlement whereas S, franciscanus did not. For purple sea urchins, northern sites formed a group, a second group was formed by sites near Santa Barbara plus a site in Orange County, and a third group was formed by 3 sites at San Diego. C1 CALIF DEPT FISH & GAME, FT BRAGG, CA 95437 USA. RP EBERT, TA (reprint author), SAN DIEGO STATE UNIV, DEPT BIOL, SAN DIEGO, CA 92182 USA. NR 61 TC 78 Z9 79 U1 2 U2 16 PU INTER-RESEARCH PI OLDENDORF LUHE PA NORDBUNTE 23, D-21385 OLDENDORF LUHE, GERMANY SN 0171-8630 J9 MAR ECOL PROG SER JI Mar. Ecol.-Prog. Ser. PD AUG PY 1994 VL 111 IS 1-2 BP 41 EP 52 DI 10.3354/meps111041 PG 12 WC Ecology; Marine & Freshwater Biology; Oceanography SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Oceanography GA PB967 UT WOS:A1994PB96700005 ER PT J AU LIBELO, EL MACINTYRE, WG SEITZ, RD LIBELO, LF AF LIBELO, EL MACINTYRE, WG SEITZ, RD LIBELO, LF TI CYCLING OF WATER THROUGH THE SEDIMENT-WATER INTERFACE BY PASSIVE VENTILATION OF RELICT BIOLOGICAL STRUCTURES SO MARINE GEOLOGY LA English DT Article; Proceedings Paper CT Session on Tidal and Shallow-Sea Sediments - Modern Environments, held at the 29th International Geological Congress CY AUG 27-28, 1992 CL KYOTO, JAPAN ID BOTTOM BOUNDARY-LAYER; DEEP-SEA SEDIMENTS; LONG-ISLAND SOUND; DIAGENETIC PROCESSES; COMMUNITY STRUCTURE; MARINE-SEDIMENTS; TURBULENT-FLOW; TRANSPORT; BURROWS; PATTERNS AB The biogeochemical environment of benthic sediments is affected by seawater transport across the sediment-water interface and within the sediment pore spaces. Water circulation through the near surface sediments is produced by passive pumping of relict biostructures such as worm tubes and burrows. This passive ventilation results from hydrodynamic interactions between structures that protrude from the sediment surface and flowing water in the overlying boundary layer. Flow over the end of a cylindrical worm tube projecting above the sediment surface into the benthic boundary layer results in lowered pressure in the tube and in sediments around the bottom end of the tube. This induces flow of surface water through the adjacent sediment, and back to the surface through tube. A physical mechanism for this passive circulation is presented. A mathematical model of interstitial water circulation produced by passive hydrodynamic effects has been solved analytically for steady flow in homogeneous isotropic sediments. MODFLOW, a finite difference groundwater flow model, is used to numerically determine the hydraulic gradients induced and the resulting flow through sediments near a structure under various conditions. The magnitude of passive irrigation fluxes depends on the size and position of relict structures, velocity of overlying surface water, hydraulic conductivity of the sediments, and the spatial distribution of tubes. For a typical sandy sediment, the hydraulic head in sediments near the bottom of a tube can be reduced by up to several centimeters, and the zone of reduced head can extend over several hundred square centimeters around the tube. Surface water is drawn into the sediment throughout this area with a mean influx velocity of 10(-3) cm/s or greater, yielding discharge rates on the order of tens to hundreds of milliliters per hour. These passive fluxes are of the same magnitude as active pumping rates, significantly greater than molecular diffusive fluxes, and may represent a major driving mechanism for cycling water through surface sediments. C1 USA,RES LAB,ADELPHI,MD 20783. RP LIBELO, EL (reprint author), COLL WILLIAM & MARY,SCH MARINE SCI,VIRGINIA INST MARINE SCI,GLOUCESTER POINT,VA 23062, USA. NR 46 TC 10 Z9 10 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0025-3227 J9 MAR GEOL JI Mar. Geol. PD AUG PY 1994 VL 120 IS 1-2 BP 1 EP 12 PG 12 WC Geosciences, Multidisciplinary; Oceanography SC Geology; Oceanography GA PF476 UT WOS:A1994PF47600002 ER PT J AU CLOUGH, RB SHAPIRO, AJ LUCEY, GK AF CLOUGH, RB SHAPIRO, AJ LUCEY, GK TI EFFECTS OF RESIDUAL POROSITY ON STRENGTH OF SN-PB/CU6SN5 PARTICULATE COMPOSITES SO MATERIALS SCIENCE AND TECHNOLOGY LA English DT Article ID PLASTICITY; RUPTURE AB The effect of residual porosity on the flow stress of particulate composites was studied for a composite in which it is possible to create high porosity (> 60%) by using particle coatings. The material was a eutectic composition Sn-Pb solder with additions of intermetallic Cu6Sn5 particles. It was found that porosity affects the strength of these composites much less than for non-composites, an effect attributed to particle bonding during solidification. At the same time, residual porosity was found to inhibit strongly or even to prevent hardening of this material. A micromechanical model is developed which simulates this behaviour over a wide range of porosities. C1 ARMY RES LAB, ADELPHI, MD USA. RP CLOUGH, RB (reprint author), NATL INST STAND & TECHNOL, GAITHERSBURG, MD USA. NR 19 TC 0 Z9 0 U1 0 U2 1 PU MANEY PUBLISHING PI LEEDS PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND SN 0267-0836 EI 1743-2847 J9 MATER SCI TECH-LOND JI Mater. Sci. Technol. PD AUG PY 1994 VL 10 IS 8 BP 696 EP 701 PG 6 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA PR617 UT WOS:A1994PR61700005 ER PT J AU NORTON, WN BROWN, CR LEWIS, MG RIPPY, MK MARTIN, JE ZACK, PM AF NORTON, WN BROWN, CR LEWIS, MG RIPPY, MK MARTIN, JE ZACK, PM TI CHARACTERIZATION OF SIMIAN IMMUNODEFICIENCY VIRUS (SIV) INFECTED AA-2 CELLS BY SEM AND IMMUNOELECTRON MICROSCOPY SO MICROSCOPY RESEARCH AND TECHNIQUE LA English DT Article DE B LYMPHOCYTES; AIDS; HIV; IMMUNODEFICIENCY; SCANNING ELECTRON MICROSCOPY; SIV ID SCANNING ELECTRON-MICROSCOPY; SOOTY MANGABEYS; LEUKOCYTES; RHESUS; LINES AB The ultrastructural features of AA-2 cells infected with either of two strains of simian immunodeficiency virus (SIVMne-E11S or SIVSMM-PBj) were examined by scanning electron microscopy (SEM). Transformed CD4+ human B lymphocytes (AA-2) were inoculated with SIV and observed at 2, 4, and 7 days post-inoculation (dPI). Infected AA-2 cells were distinguished by the progressive loss of microvilli, and variable numbers of free or protruding spherical particles measuring 90-120nm in diameter along the cell surface. Syncytial cell formation (complexes of fused cells) and necrotic cells were evident at each time point with the most numerous observations at 7 dPI. While the distribution and severity of the viral induced changes increased with time and affected virtually all cells by 7 dPI, the alterations were detected sooner and were more pronounced in SIVSMM-PBj infected cells. This finding is consistent with the in vivo data from primate studies using the same strains of SIV. Syncytial cells exhibited slight to moderate indentations which appeared to coincide with the boundaries of individual cells forming the complex. The plasma membrane of syncytial cells was relatively smooth and lacked microvilli. Spherical particles and buds protruding from the plasma membrane were predominate features of syncytial cell surfaces. By the employment of antisera generated against whole SIVMne-E11S, both transmission and scanning immunoelectron microscopy confirmed the identity of the spherical structures as free and budding SIV virions. (C) 1994 Wiley-Liss, Inc. C1 HENRY M JACKSON FDN,ROCKVILLE,MD 20850. ELI LILLY & CO,LILLY RES LABS,GREENFIELD,IN 46140. NIAID,INFECT DIS LAB,ROCKVILLE,MD 20852. WALTER REED ARMY MED CTR,DIV RETROVIROL,WASHINGTON,DC 20307. RP NORTON, WN (reprint author), SE LOUISIANA UNIV,BOX 335,HAMMOND,LA 70402, USA. NR 16 TC 0 Z9 0 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 1059-910X J9 MICROSC RES TECHNIQ JI Microsc. Res. Tech. PD AUG 1 PY 1994 VL 28 IS 5 BP 430 EP 439 DI 10.1002/jemt.1070280510 PG 10 WC Anatomy & Morphology; Biology; Microscopy SC Anatomy & Morphology; Life Sciences & Biomedicine - Other Topics; Microscopy GA NU578 UT WOS:A1994NU57800009 PM 7919531 ER PT J AU JENNINGS, BM BROSCH, LR AF JENNINGS, BM BROSCH, LR TI CLINICAL CASE-MANAGEMENT IN THE ARMY MEDICAL DEPARTMENT SO MILITARY MEDICINE LA English DT Article AB Clinical case management is a system that has the potential to improve the efficiency and effectiveness of health care delivery. Given this potential, the Army Medical Department (AMEDD) is examining this process as a means to achieve goals of quality care and cost effectiveness. In this article, the authors describe the concept of case management, the AMEDD system of clinical case management, the implementation of clinical case management in the AMEDD, and the role of the case manager. RP JENNINGS, BM (reprint author), USA,OFF ARMY SURGEON GEN,DIV CLIN POLICY,5111 LEESBURG PIKE,FALLS CHURCH,VA 22041, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 1994 VL 159 IS 8 BP 548 EP 553 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA PP246 UT WOS:A1994PP24600002 PM 7824146 ER PT J AU SPAIN, J AF SPAIN, J TI PHARMACY OPERATIONS IN THE 2ND INFANTRY DIVISION SO MILITARY MEDICINE LA English DT Article AB A forward-deployed infantry division offers many challenges to its medical elements. These elements work in a peacetime environment providing quality medical care while preparing and training for a wartime mission to conserve the fighting strength. Pharmacy operations play significant roles in the accomplishment of both missions. The roles of the Division Pharmacist and the provision of pharmacy services in the Second Infantry Division are discussed. RP SPAIN, J (reprint author), USA,MED MAT CTR EUROPE,PHARMACEUT AFFAIRS,APO,AE 09138, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 1994 VL 159 IS 8 BP 557 EP 561 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA PP246 UT WOS:A1994PP24600004 PM 7824148 ER PT J AU CHISICK, MC AF CHISICK, MC TI QUALITY AND ADEQUACY OF TRAINING OF EXPANDED FUNCTION DENTAL AUXILIARIES IN THE UNITED-STATES-ARMY SO MILITARY MEDICINE LA English DT Article AB This study explores the quality and adequacy of training U.S. Army expanded function dental auxiliaries (X2s). Data were collected in the spring of 1989 using self-administered questionnaires from dental commanders, clinic chiefs, X2 graduates, dentists working with X2s, and potential X2 students. Nearly all (94.2%) dental activities personnel responded. Results show overall performance of X2s was rated excellent or very good by 76% of commanders, 70% of clinic chiefs, and 42% of dentists. Of 23 job-specific tasks assessed, X2s received lowest performance ratings for placement of complex composite restorations and highest ratings for individual topical fluoride application. Of X2 graduates, 82% rated the overall quality of X2 training as very good or excellent. X2 graduates and their supervisors recommend retaining each job-specific skill in the X2 training program while lengthening the program from 16 to 28-30 weeks. Training of U.S. Army X2s may offer a model to other dental care systems with limited resources. RP CHISICK, MC (reprint author), USA,INST DENT RES,FT GEORGE G MEADE,MD, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 1994 VL 159 IS 8 BP 562 EP 568 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA PP246 UT WOS:A1994PP24600005 PM 7824149 ER PT J AU NOTTESTAD, SY MASCETTE, AM AF NOTTESTAD, SY MASCETTE, AM TI NITROGLYCERIN-INDUCED HEPARIN RESISTANCE - ABSENCE OF INTERACTION AT CLINICALLY RELEVANT DOSES SO MILITARY MEDICINE LA English DT Article AB A diminution in the anticoagulant effect of IV heparin with concomitant use of IV nitroglycerin has been reported. However, recent reports have disputed the existence of this interaction. The objective of this study was to assess the potential interaction of these agents in a clinical setting. Forty-five patients hospitalized with angina or acute myocardial infarction received low-dose nitroglycerin (5-20 mug/minute), and 13 received high-dose nitroglycerin (80-240 mug/minute). The two groups were similar with respect to sex, age, weight, and angina class; however, the high-dose group had a greater degree of congestive heart failure. The heparin dose required to achieve therapeutic anticoagulation did not differ between the groups. Results suggest no inhibition of heparin anticoagulation by IV nitroglycerin at clinically relevant doses. RP NOTTESTAD, SY (reprint author), BROOKE ARMY MED CTR,DEPT MED,CARDIOL SERV,HSHE MDC,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 1994 VL 159 IS 8 BP 569 EP 571 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA PP246 UT WOS:A1994PP24600006 PM 7824150 ER PT J AU BOTTINI, AG PRIEST, JG MURRAY, R WILEY, PD MOORE, RK SMITH, B CRANDALL, DB AF BOTTINI, AG PRIEST, JG MURRAY, R WILEY, PD MOORE, RK SMITH, B CRANDALL, DB TI DEVELOPMENT OF A USER-DEFINED SURGICAL DATABASE USING A PERSONAL-COMPUTER NETWORK SO MILITARY MEDICINE LA English DT Article AB Advances in personal computer technology have made powerful methods for the collection and analysis of patient information available to clinical users. This report details the development of a multi-user database distributed across a network of personal computers that facilitates operative scheduling, and collection and analysis of operative data. Clinicians from each surgical service in our medical center developed customized data entry programs that contribute information centrally through a telephone-line network to prepare the daily operative schedule. Subsequently, information from the operating rooms is added to the preoperative database to form an operative log, which is distributed to client services for further analysis and modification. This system has improved the efficiency and accuracy of operative scheduling and information management and shifted the burden of data collection away from the physician. Widespread availability of these data has contributed to the development of an effective quality improvement program and facilitated effective management of personnel and resources. RP BOTTINI, AG (reprint author), TRIPLER ARMY MED CTR,DEPT SURG,NEUROSURG SERV,HSMK DSN,HONOLULU,HI 96859, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 1994 VL 159 IS 8 BP 571 EP 576 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA PP246 UT WOS:A1994PP24600007 PM 7824151 ER PT J AU WITTICH, AC POLZIN, WJ THOMAS, CS AF WITTICH, AC POLZIN, WJ THOMAS, CS TI INCARCERATION OF THE GRAVID UTERUS DUE TO AN IMPACTED LEIOMYOMA - A CASE-REPORT SO MILITARY MEDICINE LA English DT Note RP WITTICH, AC (reprint author), TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,HONOLULU,HI 96859, USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 1994 VL 159 IS 8 BP 583 EP 584 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA PP246 UT WOS:A1994PP24600010 PM 7824154 ER PT J AU ALARCON, CM SON, HJ HALL, T DONELSON, JE AF ALARCON, CM SON, HJ HALL, T DONELSON, JE TI A MONOCISTRONIC TRANSCRIPT FOR A TRYPANOSOME VARIANT SURFACE GLYCOPROTEIN SO MOLECULAR AND CELLULAR BIOLOGY LA English DT Article ID GENE-EXPRESSION SITE; RNA POLYMERASE-II; SPLICED LEADER SEQUENCE; ANTIGENIC VARIATION; VSG GENE; BRUCEI-RHODESIENSE; AFRICAN TRYPANOSOMES; MESSENGER-RNAS; BLOOD-STREAM; T-BRUCEI AB Many protein-encoding genes of African trypanosomes are transcribed as large polycistronic pre-mRNAs that are processed into individual mRNAs containing a 5' spliced leader and 3' poly(A). The 45- to 60-kb pre-mRNAs encoding some variant surface glycoproteins (VSGs) contain as many as eight unrelated coding regions. Here eve identify the promoter for a metacyclic VSG gene that is expressed without duplication in a bloodstream trypanosome clone. This 70-bp promoter is located 2 kb upstream of the telomere-linked VSG gene and directs the synthesis of a monocistronic VSG pre-mRNA lacking the 5' spliced leader. Its sequence only slightly resembles those of other known trypanosome promoters, but it does cross-hybridize with several related sequences elsewhere in the genome. These results suggest that a new class of trypanosome promoters has been found, whose function is to initiate monocistronic transcription of those VSG genes normally expressed during the metacyclic stage. C1 UNIV IOWA,DEPT BIOCHEM,IOWA CITY,IA 52242. UNIV IOWA,HUMAN NUTR PROGRAM,IOWA CITY,IA 52242. UNIV IOWA,HOWARD HUGHES MED INST,IOWA CITY,IA 52242. WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307. RI Donelson, John/F-5795-2010 NR 77 TC 63 Z9 63 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0270-7306 J9 MOL CELL BIOL JI Mol. Cell. Biol. PD AUG PY 1994 VL 14 IS 8 BP 5579 EP 5591 PG 13 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA NY429 UT WOS:A1994NY42900057 PM 8035832 ER PT J AU ARMONDA, RA CITRIN, CM FOLEY, KT ELLENBOGEN, RG AF ARMONDA, RA CITRIN, CM FOLEY, KT ELLENBOGEN, RG TI QUANTITATIVE CINE-MODE MAGNETIC-RESONANCE-IMAGING OF CHIARI-I MALFORMATIONS - AN ANALYSIS OF CEREBROSPINAL-FLUID DYNAMICS SO NEUROSURGERY LA English DT Article DE CEREBROSPINAL FLUID; CHIARI MALFORMATION; MAGNETIC RESONANCE IMAGING; SYRINGOMYELIA ID CSF FLOW; MR; SYRINGOMYELIA; POSITION; SHUNT; SPINE AB QUANTITATIVE CINE-MODE MAGNETIC resonance imaging of the craniocervical junction was performed in 17 patients with a Chiari 1 malformation to evaluate cerebrospinal fluid (CSF) dynamics, including 8 patients who underwent surgery. The cine-mode magnetic resonance images of these patients were compared with those of 12 normal pediatric and adult subjects. The craniocervical junction was imaged by 16 cardiac-gated velocity-encoded images arranged in a cine loop. These images allowed the measurement of both the magnitude and direction of CSF velocity. Velocity measurements were made in four regions of interest-the foramen Magendie, the foramen magnum, and ventral and dorsal to the spinal cord at C2-and were plotted in relation to the cardiac cycle to produce a CSF velocity profile. All patients who underwent surgery had the same procedure: a posterior fossa craniectomy with C1 laminectomy, lysis of arachnoid adhesions, and duraplasty. Normal subjects had unobstructed flow around the craniocervical junction: a short period of cranial CSF flow was followed by a sustained period of caudal CSF flow. Patients with tonsillar herniation of more than 5 mm had obstructed CSF flow, decreased CSF velocity, and shorter periods of caudal CSF flow. These patients also had preferential cranial CSF flow as compared with the controls. Postoperatively, there was a substantial increase in both the velocity of CSF flow and in the period of caudal CSF flow in the foramen magnum. The postoperative changes mirrored the velocity profiles of the normal subjects. These changes in CSF velocity and direction correlated with a more normal-appearing foramen magnum, a reduction in syrinx size, and an improvement in symptoms. C1 WALTER REED ARMY MED CTR,NEUROSURG SERV,WASHINGTON,DC 20307. SEMMES MURPHEY CLIN,MEMPHIS,TN. UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. NR 42 TC 119 Z9 123 U1 3 U2 8 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0148-396X J9 NEUROSURGERY JI Neurosurgery PD AUG PY 1994 VL 35 IS 2 BP 214 EP 223 PG 10 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA PA207 UT WOS:A1994PA20700017 PM 7969828 ER PT J AU WATKINS, WR DUTRO, RW AF WATKINS, WR DUTRO, RW TI CONTRAST TRANSMISSION PREDICTIONS VERSUS FAR-INFRARED IMAGER MEASUREMENTS FOR LOW-ALTITUDE HORIZONTAL PATHS SO OPTICAL ENGINEERING LA English DT Article AB The Mobile Imaging Spectroscopy Laboratory of the U.S. Army Research Laboratory was used to measure horizontal-path contrast transmission with 8- to 12-mum imagers in 1988. The values obtained were only about one-half of what was predicted by LOWTRAN7. In 1990 a large-area target board, 1.8 x 1.8 m, was used and resulted in resolvable temperatures that could be consistently measured over a 1.6-km path, even during times of strong optical turbulence, and were compared to 0.1-km reference temperatures to obtain values of contrast transmission. These new measurements compare very well with LOWTRAN7 calculations except for cases when aerosol attenuations from patches of ground fog and vehicular dust were present but not included in the calculations. C1 NEW MEXICO STATE UNIV,LAS CRUCES,NM 88003. RP WATKINS, WR (reprint author), USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 10 TC 2 Z9 2 U1 0 U2 0 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD AUG PY 1994 VL 33 IS 8 BP 2588 EP 2593 DI 10.1117/12.177118 PG 6 WC Optics SC Optics GA PB299 UT WOS:A1994PB29900012 ER PT J AU RUFFIN, PB LOFTS, C SUNG, CC PAGE, JL AF RUFFIN, PB LOFTS, C SUNG, CC PAGE, JL TI REDUCTION OF NONRECIPROCITY NOISE IN WOUND FIBER OPTIC INTERFEROMETERS SO OPTICAL ENGINEERING LA English DT Article DE NONRECIPROCITY; WIND SCHEMES; COILS; FIBER OPTIC INTERFEROMETERS AB Nonreciprocity caused by temperature-rate-induced phase bias in fiber optic interferometers is experimentally investigated. A series of temperature ramp rates is applied to several fiber optic test coils to produce time-varying thermal gradients along the axial and radial directions. Data on the induced peak rate are presented for coils wound using the conventional (end-to-end) wind and the quadrupolar (center-to-end) wind. The quadrupolar-wound coil exhibits substantially lower sensitivity to temperature transients. It is found that the conventional wind can be considered for low-performance, low-cost systems operating in moderately adverse environments. C1 SMITH IND,GRAND RAPIDS,MI 49518. UNIV ALABAMA,DEPT PHYS,HUNTSVILLE,AL 35899. RP RUFFIN, PB (reprint author), USA,CTR RD&E,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898, USA. NR 5 TC 5 Z9 5 U1 1 U2 1 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD AUG PY 1994 VL 33 IS 8 BP 2675 EP 2679 DI 10.1117/12.173562 PG 5 WC Optics SC Optics GA PB299 UT WOS:A1994PB29900026 ER PT J AU FOLKES, PA DUTTA, M RUDIN, S SHEN, H ZHOU, W SMITH, D TAYSINGLARA, M NEWMAN, P COLE, M AF FOLKES, PA DUTTA, M RUDIN, S SHEN, H ZHOU, W SMITH, D TAYSINGLARA, M NEWMAN, P COLE, M TI EXCITONIC RECOMBINATION OF DEGENERATE 2-DIMENSIONAL ELECTRONS WITH LOCALIZED PHOTOEXCITED HOLES IN A SINGLE-HETEROJUNCTION QUANTUM-WELL - REPLY SO PHYSICAL REVIEW LETTERS LA English DT Note ID SCATTERING RP FOLKES, PA (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD AUG 1 PY 1994 VL 73 IS 5 BP 775 EP 775 DI 10.1103/PhysRevLett.73.775 PG 1 WC Physics, Multidisciplinary SC Physics GA NZ549 UT WOS:A1994NZ54900044 ER PT J AU KANSAS, L ROBERTSON, D AF KANSAS, L ROBERTSON, D TI ANALYSIS OF 2-NITRODIPHENYLAMINE AND ITS MAJOR DERIVATIVES IN DOUBLE AND TRIPLE BASE PROPELLANTS SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article ID PERFORMANCE LIQUID-CHROMATOGRAPHY AB High performance liquid chromatography is used to separate 2-nitrodiphenylamine and its major reaction products with nitrogen oxides in double and triple base rocket and artillery propellants. A reversed phase, isocratic technique is employed. Analysis of samples stored at ambient and elevated temperatures is discussed. C1 USA,CTR RES DEV & ENGN,ARDEC,PICATINNY ARSENAL,NJ 07806. RP KANSAS, L (reprint author), GEOCENTERS INC,LAKE HOPATCONG,NJ 07849, USA. NR 11 TC 1 Z9 1 U1 1 U2 3 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD AUG PY 1994 VL 19 IS 4 BP 171 EP 173 DI 10.1002/prep.19940190404 PG 3 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA QD844 UT WOS:A1994QD84400003 ER PT J AU MANKA, AS DOWLING, JP BOWDEN, CM FLEISCHHAUER, M AF MANKA, AS DOWLING, JP BOWDEN, CM FLEISCHHAUER, M TI A REVIEW OF LOCAL-FIELD EFFECTS IN LASING WITHOUT INVERSION SO QUANTUM OPTICS LA English DT Article AB We review the effects of density dependent near dipole-dipole, or local field, interactions on lasing without inversion. In particular, we consider the nonlinear behaviour of the macroscopic electric susceptibility of a dense, coherently prepared, three-level LAMBDA system. For certain values of the atomic density, we observe enhancement of the absorptionless index of refraction and inversionless gain by more than two orders of magnitude. We also predict a piezophotonic switching effect whereby a small change in density induces the system to flip from a strong absorber into a local field enhanced inversionless amplifier. RP MANKA, AS (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,AMSMI,RD,WS ST,REDSTONE ARSENAL,AL 35898, USA. RI Fleischhauer, Michael/G-6716-2011; DOWLING, JONATHAN/L-2749-2013 NR 0 TC 27 Z9 27 U1 0 U2 0 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0954-8998 J9 QUANTUM OPT PD AUG PY 1994 VL 6 IS 4 BP 371 EP 380 DI 10.1088/0954-8998/6/4/014 PG 10 WC Optics; Physics, Applied SC Optics; Physics GA PD672 UT WOS:A1994PD67200015 ER PT J AU HELMS, CR POINDEXTER, EH AF HELMS, CR POINDEXTER, EH TI THE SILICON SILICON-DIOXIDE SYSTEM - ITS MICROSTRUCTURE AND IMPERFECTIONS SO REPORTS ON PROGRESS IN PHYSICS LA English DT Review ID ELECTRON-SPIN RESONANCE; RAY PHOTOELECTRON-SPECTROSCOPY; RADIOLYTIC MOLECULAR-HYDROGEN; INTERFACE TRAP FORMATION; RECHARGEABLE E' CENTERS; 111 SI/SIO2 INTERFACE; ULTRATHIN SIO2 LAYERS; SI-SIO2 INTERFACE; OXIDIZED SILICON; THERMAL SIO2 AB The microstructural features of the Si-SiO2 system and the chemical physics of its defects are reviewed and examined. Topics are grouped by scientific commonality, rather than by the usual technological manifestations. The role of atomic and molecular sized entities is emphasized, and the latter are limited to those containing only Si, O, H, or combinations thereof. Most of the reported researches involve x-ray or electron diffraction, Auger or photoelectron spectroscopy, Rutherford back scattering, electron spin resonance, or capacitance-voltage or deep-level transient spectroscopy. Several forms of crystalline and amorphous vitreous silica are considered as a basis for discussion of thin film thermal silica on silicon wafers. Local lattice symmetry, stoichiometry, bond lengths and angles, vacancies and voids, dangling orbital centres, and fixed and migratory hydrogen species are treated extensively. Elements of relevant theory are summarized. Overall, it is hoped to provide a solid data base for future development of general models for essential electronic phenomena in the Si-SiO2 system. C1 USA, RES LAB, FT MONMOUTH, NJ 07703 USA. RP STANFORD UNIV, STANFORD, CA 94305 USA. NR 186 TC 260 Z9 260 U1 7 U2 63 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0034-4885 EI 1361-6633 J9 REP PROG PHYS JI Rep. Prog. Phys. PD AUG PY 1994 VL 57 IS 8 BP 791 EP 852 DI 10.1088/0034-4885/57/8/002 PG 62 WC Physics, Multidisciplinary SC Physics GA PD678 UT WOS:A1994PD67800002 ER PT J AU LEITNER, W BERGMANN, ES THALHAMER, J AF LEITNER, W BERGMANN, ES THALHAMER, J TI REGENERATION OF SPLENIC STROMAL ELEMENTS SO RESEARCH IN EXPERIMENTAL MEDICINE LA English DT Article DE SPLENIC REGENERATION; SPLENIC AUTOTRANSPLANTATION; SPLENIC STROMA MITOGEN STIMULATION; CELL DEPLETION ID AUTOLOGOUS SUBCUTANEOUS IMPLANTATION; WHITE PULP; RAT SPLEEN; TISSUE; CELLS; LOCALIZATION; IMMUNOARCHITECTURE; SITES; IA AB Splenic regeneration represents an interesting phenomenon both in relation to its role as a model system (to study the development of the complex three-dimensional architecture of an immunological organ) and because of the clinical application, namely autotransplantation of spleen. The latter is one of the attempts to restore splenic functions after splenectomy, which is known to increase a lifelong risk of fatal sepsis. However, splenic functions of autotransplanted splenic tissue are known to be highly dependent on the recovery of the complex microenvironment and immunoarchitecture of the splenic compartments during the regeneration processes, but the elements inducing splenic reorganization are still unknown. Therefore, the present work investigates whether splenic stroma depleted of cells is able to induce regenerative processes after implantation. In addition, we tried to recombine stromal tissue with selected cell populations to study their influence. Cell-free stromal tissue induced angiogenesis and to a lesser extent also attracted the immigration of lymphocytes during the first 60 days of regeneration. However, after this period of regeneration, the transplants began to degenerate and were resorbed. The recombination of stromal tissue with mitogen-stimulated spleen cells only resulted in intensifying the degenerative processes, and all implants were resorbed after 120 days. Except that in the first 30 days there were some accumulations of lymphocytes that resembled primitive follicles, no splenic compartments such as red pulp, periarteriolar lymphoid sheath, or marginal zone could be detected in any of the transplants. From these results it can be concluded that splenic stroma can induce the primary events of splenic regeneration (like angiogenesis), but is not able to provide an appropriate microenvironment and immunoarchitecture for a correct repopulation and differentiation of cells. Furthermore, the recombination experiments point to a minor role of T-cells and possibly an important role for accessory cells in splenic regeneration. C1 SALZBURG UNIV, INST CHEM & BIOCHEM, DEPT BIOCHEM, A-5020 SALZBURG, AUSTRIA. WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, DEPT IMMUNOL, WASHINGTON, DC 20307 USA. RI Bergmann-Leitner, Elke/B-3548-2011; Thalhamer, Josef/E-5787-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956; Thalhamer, Josef/0000-0003-2285-6400 NR 22 TC 3 Z9 3 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0300-9130 J9 RES EXP MED JI Res. Exp. Med. PD AUG PY 1994 VL 194 IS 4 BP 221 EP 230 DI 10.1007/BF02576383 PG 10 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA PC722 UT WOS:A1994PC72200002 PM 7800931 ER PT J AU MURR, LE NIOU, CS FENG, C AF MURR, LE NIOU, CS FENG, C TI RESIDUAL MICROSTRUCTURES IN EXPLOSIVELY FORMED TANTALUM PENETRATORS SO SCRIPTA METALLURGICA ET MATERIALIA LA English DT Article C1 USA,ARMAMENT RES DEV,PICATINNY ARSENAL,NJ 07806. USA,CTR ENG,PICATINNY ARSENAL,NJ 07806. RP MURR, LE (reprint author), UNIV TEXAS,DEPT MET & MAT ENGN,EL PASO,TX 79968, USA. OI Murr, Lawrence/0000-0001-5942-8376 NR 13 TC 24 Z9 24 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0956-716X J9 SCRIPTA METALL MATER JI Scr. Metall. Materialia PD AUG 1 PY 1994 VL 31 IS 3 BP 297 EP 302 DI 10.1016/0956-716X(94)90286-0 PG 6 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA NM940 UT WOS:A1994NM94000012 ER PT J AU SHI, S WA, PLK MILLER, A PAMULAPATI, J COOKE, P DUTTA, M AF SHI, S WA, PLK MILLER, A PAMULAPATI, J COOKE, P DUTTA, M TI THE CONTROLLED DISORDERING OF QUANTUM-WELLS USING SURFACE OXIDATION SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY LA English DT Letter ID DIFFUSION AB A new technique has been developed, which allows the controlled, partial disordering of GaAs/AlGaAs multiple quantum wells, using thermal diffusion of aluminium and/or gallium vacancies created by etching the surface oxides. Spectral measurements by photoluminescence and optical absorption indicate that the disordering can result in a blue shift of the effective band edge by up to 40 nm without broadening of the excitonic resonances. C1 UNIV ST ANDREWS,DEPT PHSY & ASTRON,ST ANDREWS KY16 9SS,FIFE,SCOTLAND. UNIV CENT FLORIDA,DEPT ELECT & COMP ENGN,ORLANDO,FL 32826. USA,AMSRL EP EC,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703. RP SHI, S (reprint author), UNIV CENT FLORIDA,CREOL,12424 RES PKWY,ORLANDO,FL 32826, USA. NR 9 TC 5 Z9 5 U1 0 U2 0 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0268-1242 J9 SEMICOND SCI TECH JI Semicond. Sci. Technol. PD AUG PY 1994 VL 9 IS 8 BP 1564 EP 1566 DI 10.1088/0268-1242/9/8/021 PG 3 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA PA827 UT WOS:A1994PA82700021 ER PT J AU CHEN, ZX COCKBURN, B AF CHEN, ZX COCKBURN, B TI ERROR-ESTIMATES FOR A FINITE-ELEMENT METHOD FOR THE DRIFT-DIFFUSION SEMICONDUCTOR-DEVICE EQUATIONS SO SIAM JOURNAL ON NUMERICAL ANALYSIS LA English DT Article DE SEMICONDUCTOR DEVICES; CONSERVATION LAWS; FINITE ELEMENTS; ERROR ESTIMATES ID MISCIBLE DISPLACEMENT; APPROXIMATION AB In this paper, optimal error estimates are obtained for a method for numerically solving the so-called unipolar model (a one-dimensional simplified version of the drift-diffusion semi-conductor device equations). The numerical method combines a mixed finite element method using a continuous piecewise-linear approximation of the electric field with an explicit upwinding finite element method using a piecewise-constant approximation of the electron concentration. For initial and boundary data ensuring that the electron concentration is smooth, the L(infinity)(L1)-error for the electron concentration and the L(infinity) (L(infinity))-error of the electric field are both proven to be of order DELTAx. The error analysis is carried out first in the zero diffusion case in detail and then extended to the full unipolar model. C1 UNIV MINNESOTA,SCH MATH,MINNEAPOLIS,MN 55455. RP CHEN, ZX (reprint author), UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,1100 WASHINGTON AVE S,MINNEAPOLIS,MN 55415, USA. RI Cockburn, Bernardo/M-9617-2013 OI Cockburn, Bernardo/0000-0001-6085-3441 NR 5 TC 8 Z9 8 U1 0 U2 1 PU SIAM PUBLICATIONS PI PHILADELPHIA PA 3600 UNIV CITY SCIENCE CENTER, PHILADELPHIA, PA 19104-2688 SN 0036-1429 J9 SIAM J NUMER ANAL JI SIAM J. Numer. Anal. PD AUG PY 1994 VL 31 IS 4 BP 1062 EP 1089 DI 10.1137/0731056 PG 28 WC Mathematics, Applied SC Mathematics GA PB027 UT WOS:A1994PB02700006 ER PT J AU GLASS, KL DILLARD, TA DENNIS, GJ DACEY, MJ DWYER, TX AF GLASS, KL DILLARD, TA DENNIS, GJ DACEY, MJ DWYER, TX TI PYOGENIC ARTHRITIS COMPLICATING VARICELLA INFECTION SO SOUTHERN MEDICAL JOURNAL LA English DT Note AB Arthritis has not previously been reported as a complication in adult patients with chickenpox. In pediatric patients, the arthritis that complicates chickenpox is most commonly aseptic but does rarely result from bacterial infection. We report the case of a 21-year-old man who developed acute monoarticular septic arthritis due to Lancefield Group A beta-hemolytic streptococci. Despite the more common viral cause of arthritis in pediatric patients, physicians should not attribute arthritis associated with varicella in adults to a viral cause without diagnostic arthrocentesis. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. RP GLASS, KL (reprint author), WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307, USA. NR 9 TC 10 Z9 10 U1 0 U2 1 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD AUG PY 1994 VL 87 IS 8 BP 857 EP 859 DI 10.1097/00007611-199408000-00025 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA PB488 UT WOS:A1994PB48800025 PM 8052905 ER PT J AU PARKER, MJM TORRINGTON, KG PHILLIPS, YY AF PARKER, MJM TORRINGTON, KG PHILLIPS, YY TI SARCOIDOSIS COMPLICATED BY CHYLOTHORAX SO SOUTHERN MEDICAL JOURNAL LA English DT Note ID HODGKINS-DISEASE; GRANULOMAS AB Chylothorax is a rare complication of sarcoidosis; only one well-documented case has been described previously. Before chylothoraxis diagnosed in a patient with sarcoidosis, infection and malignancy need to be aggressively excluded as possible diagnoses. We report the case of a 34-year-old black woman with sarcoidosis confirmed by lung, pleural, and mediastinal lymph node biopsies whose clinical course was complicated by chylothorax. Oral corticosteroid treatment resulted in prompt resolution of the chylothorax. RP WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. NR 10 TC 8 Z9 8 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0038-4348 EI 1541-8243 J9 SOUTH MED J JI South.Med.J. PD AUG PY 1994 VL 87 IS 8 BP 860 EP 862 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA PB488 UT WOS:A1994PB48800026 ER PT J AU OCONNOR, FG AF OCONNOR, FG TI UNTITLED - RESPONSE SO SPINE LA English DT Letter RP OCONNOR, FG (reprint author), USA,FT BELVOIR,VA 22060, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0362-2436 J9 SPINE JI SPINE PD AUG 1 PY 1994 VL 19 IS 15 BP 1772 EP 1772 DI 10.1097/00007632-199408000-00023 PG 1 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA PA344 UT WOS:A1994PA34400023 ER PT J AU WAS, GS DEMAREE, JD ROTBERG, V KIM, K AF WAS, GS DEMAREE, JD ROTBERG, V KIM, K TI CORROSION AND MECHANICAL-BEHAVIOR OF ION-IMPLANTED BEARING STEELS FOR IMPROVED FRETTING BEHAVIOR SO SURFACE & COATINGS TECHNOLOGY LA English DT Article ID WEAR AB Ion implantation of AISI 52100 and 1070 steels was conducted in order to improve the corrosion, wear and ultimately the fretting behavior of the steels. Implantations consisted of 1 X 10(17) Ta+ cm-2, 3 x 10(17) Ti+ cm-2+1.5 x 10(17) C+ cm-2, and 3.1 x 10(17) Ti+ cm-2 + 1.55 x 10(17) N2+ cm-2. All implantations were successful in improving the corrosion resistance. On average, the peak anodic current was reduced by over 300 mV, the passivation potential was reduced, and the pitting potential was increased by over 1000 mV in 0.01 M NaCl. Ti + C and Ti + N implantations increased the load-carrying capacity in lubricated scuffing tests by 60% and 40% respectively. Ta produced no improvement in scuffing resistance. Ti + N implantation increased the hardness by 25% over the unimplanted steel and both Ti + C and Ta implantation reduced the surface hardness. Fretting wear was reduced only slightly in the Ta implanted sample and increased in both the Ti + C and Ti + N implanted samples with the latter showing 4-5 times the weight loss as the unimplanted sample. The correlation between fretting and hardness supports a mechanism in which the hard surface layer breaks into fine particles which act as an abrasive under the intense load of the balls. C1 UNIV MICHIGAN,DEPT NUCL ENGN,MICHIGAN ION BEAM LAB,ANN ARBOR,MI 48109. UNIV MICHIGAN,DEPT MECH ENGN & APPL MECH,ANN ARBOR,MI 48109. USA,MAT TEST LAB,MAT RES BRANCH,WATERTOWN,MA 02172. RP WAS, GS (reprint author), UNIV MICHIGAN,DEPT MAT SCI & ENGN,DEPT NUCL ENGN,213 COOLEY BLDG,ANN ARBOR,MI 48109, USA. NR 13 TC 7 Z9 10 U1 0 U2 1 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD AUG PY 1994 VL 66 IS 1-3 BP 446 EP 452 DI 10.1016/0257-8972(94)90047-7 PG 7 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA PA172 UT WOS:A1994PA17200046 ER PT J AU OGURA, H CIOFFI, WG OFFNER, PJ JORDAN, BS JOHNSON, AA PRUITT, BA AF OGURA, H CIOFFI, WG OFFNER, PJ JORDAN, BS JOHNSON, AA PRUITT, BA TI EFFECT OF INHALED NITRIC-OXIDE ON PULMONARY-FUNCTION AFTER SEPSIS IN A SWINE MODEL SO SURGERY LA English DT Article; Proceedings Paper CT 55th Annual Meeting of the Society-of-University-Surgeons CY FEB 09-12, 1994 CL JACKSON, MS SP SOC UNIV SURGEONS ID RESPIRATORY-DISTRESS SYNDROME; ENDOTOXIN-SHOCK; HYPERTENSION; INHALATION; DISTRIBUTIONS; VENTILATION; DISEASE AB Background. Inhaled nitric oxide (NO) has been shown to improve sepsis induced pulmonary dysfunction. This study evaluated the mechanism by which inhaled NO improves pulmonary function in a porcine sepsis model. Methods. After an infusion of Escherichia coli lipopolysaccharide (LPS, 200 mu g/kg), animals wer resuscitated with saline solution (1 ml/kg/min) and observed for 3 hours whil mechanically ventilated (fraction of inspired oxygen, 0.6; tidal volume, 12 ml/kg; positive end-expiratory pressure, 5 cm H2O). Group 1 (LPS, n = 6) received no additional treatment. Group 2 (NO, n = 6) received inhaled NO (40 ppm) for the last 2 hours. Group 3 (control, n = 5) received only saline solution without LPS. Cardiopulmonary variables and blood gases were measured serially. Multiple inert gas elimination technique was performed at 3 hours. Wet to dry lung weight ratio was measured after necropsy. Results. Lipopolysaccharide resulted in pulmonary arterial hypertension, pulmonary edema, and hypoxemia. Multiple inert gas elimination technique analysis indicated a sinificant increase in blood flow to true shunt and high ventilation perfusion distribution (V-A/Q) areas with an increased dispersion of V-A/Q distribution. All of these changes were significantly attenuated by NO. Conclusions. Inhaled NO significantly improved LPS induced V-A/Q mismatching by decreasing both true shunt and high V-A/Q areas, by decreasing pulmonary edema, and by redistributing blood flow from true shunt to ventilated areas. C1 USA,INST SURG RES,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DEPT CRIT CARE,FT SAM HOUSTON,TX 78234. NR 23 TC 35 Z9 37 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0039-6060 J9 SURGERY JI Surgery PD AUG PY 1994 VL 116 IS 2 BP 313 EP 321 PG 9 WC Surgery SC Surgery GA PA544 UT WOS:A1994PA54400027 PM 8047999 ER PT J AU KIANG, JG SMALLRIDGE, RC AF KIANG, JG SMALLRIDGE, RC TI SODIUM-CYANIDE INCREASES CYTOSOLIC-FREE CALCIUM - EVIDENCE FOR ACTIVATION OF THE REVERSED MODE OF THE NA+/CA2+ EXCHANGER AND CA2+ MOBILIZATION FROM INOSITOL TRISPHOSPHATE-INSENSITIVE POOLS SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article ID CULTURED RAT HEPATOCYTES; HUMAN EPIDERMOID-A-431 CELLS; RABBIT CAROTID-BODY; INTRACELLULAR CALCIUM; CHEMICAL HYPOXIA; PITUITARY-CELLS; A-431 CELLS; HEAT-SHOCK; CA-2+; PH AB This study characterized the cytosolic free Ca2+ concentration ([Ca2+](i)) in NaCN-treated human A-431 cells. The resting [Ca2+](i) was 85 +/- 8 nM (n = 141) in untreated cells at 37 degrees C, determined with the fura-2 fluorescence probe, When cells were treated with NaCN, [Ca2+](i) increased in a time- and NaCN concentration-dependent manner. When cells were exposed to 10 mM NaCN for 10 min, [Ca2+](i) increased 278 +/- 28% (n = 5) but returned to normal within 45 min after treatment. The [Ca2+](i) increase depended on the presence of external Ca2+. La3+ and Cd2+, but not verapamil or nifedipine, inhibited the NaCN-induced [Ca2+](i) increase. The NaCN-induced [Ca2+](i) increase also depended on external Na+ (K-1/2 = 85 mM). The intracellular Na+ concentration, measured with the fluorescence probe SBFI, increased 267 +/- 16% after NaCN treatment. The NaCN-induced [Ca2+](i) increase was modulated by treatment with ouabain or veratridine and was completely blocked by tetrodotoxin, amiloride (K-1/2 = 5.4 mu M), and dichlorobenzamil (K-1/2 = 0.28 mu M). These results suggest NaCN activates the Na+/Ca2+ exchange system. TMB-8 and ryanodine both partially blocked the increase in [Ca2+](i) in the presence of external Ca2+, indicating that Ca2+ release from intracellular pools also occurred after the initial Ca2+ influx. NaCN decreased inositol trisphosphates production. U-73122, bradykinin, or monensin did not prevent the NaCN-induced increase in [Ca2+](i). However, the magnitude of the [Ca2+](i) increase caused by NaCN was abolished in ionomycin-treated cells, indicating that intracellular Ca2+ release induced by NaCN is derived from an ionomycin-sensitive Ca2+ pool. The results suggest that NaCN initially increased Na+ influx, which activated the reverse mode of a Na+/Ca2+ exchanger, leading to an increase in Ca2+ influx. The Ca2+ influx induced a Ca2+ mobilization from only an ionomycin-sensitive intracellular Ca2+ pool containing ryanodine receptors. (C) 1994 Academic Press, Inc. RP KIANG, JG (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT CLIN PHYSIOL,DIV MED,WASHINGTON,DC 20307, USA. NR 43 TC 27 Z9 27 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD AUG PY 1994 VL 127 IS 2 BP 173 EP 181 DI 10.1006/taap.1994.1151 PG 9 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA PA943 UT WOS:A1994PA94300001 PM 7519371 ER PT J AU GOWDA, TV MIDDLEBROOK, JL AF GOWDA, TV MIDDLEBROOK, JL TI MONOCLONAL-ANTIBODIES TO VRV-PL-VIIIA, A BASIC MULTITOXIC PHOSPHOLIPASE-A(2) FROM VIPERA-RUSSELLI VENOM SO TOXICON LA English DT Article ID SNAKE-VENOM; NEUROTOXICITY; PURIFICATION AB VRV-PL-VIIIa, the most basic phospholipase A(2) (PLA(2)) from the venom of Vipera russelli, induces multiple toxic effects, including neurotoxicity, myotoxicity, edema and hemorrhage. Rabbit polyclonal antiserum was raised against VRV-PL-VIIIa. The antiserum cross-reacted in enzyme-linked immunosorbant assay (ELISA) with two other PLA(2) from the same venom, VRV-PL-V and VRV-PL-VI, and with ammodytoxin A, caudoxin and crotoxin. Twenty-two hybridoma cell lines secreting monoclonal antibodies against VRV-PL-VIIIa were isolated. The monoclonal antibodies exhibited apparent binding affinities in ELISA with VRV-PL-VIIIa ranging over two orders of magnitude. Most of the monoclonal antibodies cross-reacted moderately with VRV-PL-V and weakly with VRV-PL-VI. None of the antibodies cross-reacted with ammodytoxin, caudoxin or crotoxin. Reducing the disulfide bonds of VRV-PL-VIIIa lowered the ELISA signals of each monoclonal antibody to nonspecific levels, suggesting that all the antibodies recognize conformational epitopes. Four of the 22 antibodies neutralized the enzymatic activity of VRV-PL-VIIIa. Interestingly, two of the four exhibited the lowest affinities of the monoclonal antibody library for VRV-PL-VIIIa in ELISA, while the other two exhibited the highest. Each of the monoclonal antibodies was biotinylated and spatial binding relationships were evaluated by competition ELISA. C1 USA,MED RES INST INFECT DIS,DIV TOXINOL,FREDERICK,MD 21702. NR 18 TC 4 Z9 4 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD AUG PY 1994 VL 32 IS 8 BP 955 EP 964 DI 10.1016/0041-0101(94)90374-3 PG 10 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA PA941 UT WOS:A1994PA94100011 PM 7985200 ER PT J AU FERNANDEZ, EB COLON, E MCLEOD, DG MOUL, JW SAGALOWSKY, AI PONTES, JE AF FERNANDEZ, EB COLON, E MCLEOD, DG MOUL, JW SAGALOWSKY, AI PONTES, JE TI EFFICACY OF RADIOGRAPHIC CHEST IMAGING IN PATIENTS WITH TESTICULAR CANCER SO UROLOGY LA English DT Article ID GERM-CELL TUMORS; WHOLE LUNG TOMOGRAPHY; COMPUTERIZED-TOMOGRAPHY; PROGNOSTIC FACTORS; METASTASES; ACCURATE AB Objectives. To determine the efficacy of computed tomography of the chest (CTC) and plain radiograph (CXR) in the initial staging process of testicular germ cell tumors. Methods. The medical records of 362 patients with testicular germ cell tumor treated at our center between January 1980 and August 1993 were reviewed with particular attention to initial chest screening studies. Two hundred one patients had both CXR and CTC, 24 CXR alone, and 20 CTC alone during initial staging. One hundred seventeen patients were excluded from analyses because of undergoing whole lung tomography (92), unknown staging (19), or inadequate follow-up (6). Analysis included findings based on abdominal staging results using computed tomography of the abdomen (CTA). Results. Of the 201 patients who had both CTC and CXR, 117 (58.2%) had nonseminomas (NSGCT) and 84 (41.8%) had seminomas (SEM). Among the patients with NSGCT, 21 (17.9%) had chest metastasis, 16 (76.2%) of which were detected by CXR. The 5 that were missed on CXR had significant retroperitoneal disease documented by CTA and the knowledge of chest metastases potentially altered therapy in 2 patients. Only 2 of 84 (2.4%) patients with SEM had metastatic chest disease and both were identified by CXR. False-positive CTC following negative CXR resulted in costly and sometimes invasive additional procedures in 10 patients with NSGCT and 6 with SEM. None of the CXR-only patients had adverse consequences from the solitary study (at least 1 year follow-up). The CTC-only patients could have undergone CXR only and had similar outcome. Conclusions. CXR alone is preferable for initial chest staging in all patients with SEM and in patients with NSGCT with negative findings on CTA. CTC remains of slight benefit for patients with clinical Stage II and greater NSGCT and to evaluate further suspicious CXR findings in any patient, although it appears not to be necessary in patients who have clinical Stage I disease determined by CTA. These findings have important cost-saving implications. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,4301 JONES BRIDGE RD,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307. UNIV TEXAS,SW MED CTR,DIV UROL,DALLAS,TX 75235. WAYNE STATE UNIV,SCH MED,DEPT UROL,DETROIT,MI 48281. NR 17 TC 15 Z9 15 U1 0 U2 1 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD AUG PY 1994 VL 44 IS 2 BP 243 EP 249 DI 10.1016/S0090-4295(94)80139-8 PG 7 WC Urology & Nephrology SC Urology & Nephrology GA PA802 UT WOS:A1994PA80200017 PM 8048200 ER PT J AU IVINS, BE FELLOWS, PF NELSON, GO AF IVINS, BE FELLOWS, PF NELSON, GO TI EFFICACY OF A STANDARD HUMAN ANTHRAX VACCINE AGAINST BACILLUS-ANTHRACIS SPORE CHALLENGE IN GUINEA-PIGS SO VACCINE LA English DT Article DE ANTHRAX; BACILLUS ANTHRACIS; VACCINE EFFICACY ID PROTECTIVE ANTIGEN; ANTIBODIES; RELEVANCE; IMMUNITY; TOXIN AB The efficacy of an anthrax vaccine licensed for human use, MDPH-PA, was tested in guinea-pigs intramuscularly challenged with 10, 100 or 1000 LD(50) Of spores from two virulent strains of Bacillus anthracis, Vollum 1B and Ames. As demonstrated in other investigations, immunization with MDPH-PA provided better protection against challenge with the Vollum 1B strain than with the Ames strain, although vaccine efficacy against the Ames strain was better than previously reported. Enzyme-linked immunosorbent assay of serum antibody titres to B. anthracis protective antigen showed that there was no significant correlation between survival and antibody titres. C1 USA,MED RES INST INFECT DIS,DIV BIOMETR & INFORMAT MANAGEMENT,FREDERICK,MD 21702. RP IVINS, BE (reprint author), USA,MED RES INST INFECT DIS,DIV BACTERIOL,FT DETRICK,FREDERICK,MD 21702, USA. NR 11 TC 65 Z9 66 U1 0 U2 1 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD AUG PY 1994 VL 12 IS 10 BP 872 EP 874 DI 10.1016/0264-410X(94)90027-2 PG 3 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA NW195 UT WOS:A1994NW19500002 PM 7975827 ER PT J AU REDDY, TA MACAIONE, D ERHAN, S AF REDDY, TA MACAIONE, D ERHAN, S TI QUINONE-AMINE POLYMERS .15. SYNTHESIS AND CHARACTERIZATION OF HIGH-TEMPERATURE RESISTANT POLY(ARYLAMINO-QUINONE)S SO JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY LA English DT Article DE POLY(ARYLAMINO-QUINONE)S; P-BENZOQUINONE; AROMATIC DIAMINE; TETRAHYDROFURAN AB Several poly (arylamino-quinone) s (PAAQs) were prepared by the conventional solution polymerization of p-benzoquinone with various aromatic diamines in tetrahydrofuran. Polymers prepared by this method were found to be more soluble in many organic solvents compared to the PAAQs prepared by other reported methods. The poly(arylamino-quinone)s were obtained in 82.3-94.5% yield and had inherent viscosities in the range of 0.073-0.251 dL/g. Among the PAAQs, the polymer prepared from p-benzoquinone and 1,3-bis (3-aminophenoxy) benzene (APB) had demonstrated exceptionally good solubility and thermal stability. (C) 1994 John Wiley & Sons, Inc. C1 ALBERT EINSTEIN MED CTR,NO DIV,CTR PROT & POLYMER RES,PHILADELPHIA,PA 19141. USA,LAB COMMAND MAT TECHNOL LAB,DEPT ARMY,WATERTOWN,MA 02172. NR 8 TC 4 Z9 6 U1 0 U2 3 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0887-624X J9 J POLYM SCI POL CHEM JI J. Polym. Sci. Pol. Chem. PD JUL 30 PY 1994 VL 32 IS 10 BP 1977 EP 1982 DI 10.1002/pola.1994.080321021 PG 6 WC Polymer Science SC Polymer Science GA NU809 UT WOS:A1994NU80900021 ER PT J AU STEPHENS, PJ CHABALOWSKI, CF DEVLIN, FJ JALKANEN, KJ AF STEPHENS, PJ CHABALOWSKI, CF DEVLIN, FJ JALKANEN, KJ TI AB-INITIO CALCULATION OF VIBRATIONAL CIRCULAR-DICHROISM SPECTRA USING LARGE BASIS-SET MP2 FORCE-FIELDS SO CHEMICAL PHYSICS LETTERS LA English DT Article ID MOLECULAR-ORBITAL PREDICTIONS; VIBRONIC COUPLING THEORY; PROPYLENE-OXIDE; ROTATIONAL STRENGTHS; PERTURBATION-THEORY; GAUGE DEPENDENCE; 2ND DERIVATIVES; TRANS-2,3-DIDEUTERIOOXIRANE; INTENSITIES; PHASE AB Ab initio calculations of the vibrational circular dichroism (VCD) spectra of 2,3-trans-d2-oxirane (1), 1,2-trans-d2-cyclopropane pane (2), 1-C-13-1,2,3-anti-d3-cyclopropane (3), and propylene oxide (4) based on [ 5s4p2d/3s2p] MP2 harmonic force fields are reported. The results are in perfect qualitative and good quantitative agreement with existing experimental VCD spectra except in the C-H stretching region of 4 where Fermi resonance occurs. Calculations for 1-3 using a larger [8s6p3d/6s3p] basis set exhibit insensitivity to a substantial increase in basis set size. C1 USA,RES LAB,AMSRL,WT,PC,ABERDEEN PROVING GROUND,MD 21005. UNIV ILLINOIS,BECKMAN INST ADV SCI & TECHNOL,URBANA,IL 61801. RP STEPHENS, PJ (reprint author), UNIV SO CALIF,DEPT CHEM,LOS ANGELES,CA 90089, USA. RI Jalkanen, Karl/A-2456-2008 NR 35 TC 19 Z9 19 U1 1 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD JUL 29 PY 1994 VL 225 IS 1-3 BP 247 EP 257 DI 10.1016/0009-2614(94)00605-9 PG 11 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA PA037 UT WOS:A1994PA03700037 ER PT J AU LEE, CY TIDROW, MZ CHOI, KK CHANG, WH EASTMAN, LF TOWNER, FJ AHEARN, JS AF LEE, CY TIDROW, MZ CHOI, KK CHANG, WH EASTMAN, LF TOWNER, FJ AHEARN, JS TI ACTIVATION CHARACTERISTICS OF A LONG-WAVELENGTH INFRARED HOT-ELECTRON TRANSISTOR SO APPLIED PHYSICS LETTERS LA English DT Article ID GAAS QUANTUM-WELL; PHOTODETECTORS AB The origin of current reduction in an infrared hot-electron transistor is examined by studying the thermal activation energy of the emitter and the collector dark current as a function of emitter bias V(e). For the emitter, the activation energy E(ae) is found to be determined by the thermionic emission (TE) process at a small V(e). At higher V(e), E(ae) decreases linearly with V(e) due to the increase of the thermally assisted tunneling (TAT) current enhanced by dopant migration. For the collector, the activation energy E(ac) is significantly higher than E(ae) at low biases, indicating that the collector accepts higher energy electrons injected from the emitter. For the device under study, at V(e)=0.5 V, the value of E(ac) is the same as that of the emitter at low biases. This result shows that, up to this bias, the collector dark current consists of only the TE current but not the TAT current, thus greatly improving the detector performance. C1 CORNELL UNIV,ITHACA,NY 14853. MARTIN MARIETTA CORP LABS,BALTIMORE,MD 21227. RP LEE, CY (reprint author), USA,RES LAB,EPSD,FT MONMOUTH,NJ 07703, USA. RI Choi, Kwong-Kit/K-9205-2013 NR 10 TC 7 Z9 7 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 25 PY 1994 VL 65 IS 4 BP 442 EP 444 DI 10.1063/1.112327 PG 3 WC Physics, Applied SC Physics GA NY414 UT WOS:A1994NY41400021 ER PT J AU ZUKAS, WX AF ZUKAS, WX TI TORSIONAL BRAID ANALYSIS OF THE AROMATIC AMINE CURE OF EPOXY-RESINS SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article ID GLASS-TRANSITION TEMPERATURE; MECHANICAL-PROPERTIES; REACTION-KINETICS; NETWORK STRUCTURE; CROSS-LINKING; SYSTEMS; TG; CONVERSION; DIAGRAMS; POLYMERS AB The cure behavior of diglycidyl ether of bisphenol A (DGEBA) type of epoxy resins with three aromatic diamines, 4,4'-diaminodiphenyl methane (DDM), 4,4'-diaminodiphenyl sulfone (44DDS), and 3,3'-diaminodiphenyl sulfone (33DDS) was studied by torsional braid analysis. For each curing agent the stoichiometry of the resin mixtures was varied from a two to one excess of amino hydrogens per epoxy group to a two to one excess of epoxy groups per amino hydrogen. Isothermal cures of the resin mixtures were carried out from 70 to 210-degrees-C (range depending on epoxy-amine mixture), followed by a temperature scan to determine the glass transition temperature (T(g)). The times to the isothermal liquid-to-rubber transition were shortest for the DDM mixtures and longest for the 44DDS mixtures. The liquid-to-rubber transition times were also shortest for the amine excess mixtures when stoichiometry was varied. A relatively rapid reaction to the liquid-to-rubber transition was observed for the epoxy excess mixtures, followed by an exceedingly slow reaction process at cure temperatures well above the T(g). This slow process was only observed for epoxy excess mixtures and eventually led to significant increases in T(g). Using time-temperature shifts of the glass transition temperature vs. logarithm of time, activation energies approximately 50% higher were derived for this process compared to those derived from the liquid-to-rubber transition. The rate of this reaction was virtually independent of curing agent and was attributed to etherification taking place in the epoxy excess mixtures. (C) 1994 John Wiley & Sons, Inc. RP ZUKAS, WX (reprint author), USA,RES LAB,PHYS & ORGAN CHEM RES BRANCH,WATERTOWN,MA 02172, USA. NR 25 TC 18 Z9 18 U1 1 U2 7 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0021-8995 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD JUL 25 PY 1994 VL 53 IS 4 BP 429 EP 440 DI 10.1002/app.1994.070530406 PG 12 WC Polymer Science SC Polymer Science GA NU139 UT WOS:A1994NU13900006 ER PT J AU HONG, SS ROMSTEDT, KJ FELLER, DR HSU, FL CUPPS, TL LYON, RA MILLER, DD AF HONG, SS ROMSTEDT, KJ FELLER, DR HSU, FL CUPPS, TL LYON, RA MILLER, DD TI A STRUCTURE-ACTIVITY RELATIONSHIP STUDY OF BENZYLIC MODIFICATIONS OF 4-[1-(1-NAPHTHYL)ETHYL]-1H-IMIDAZOLES ON ALPHA(1)-ADRENERGIC AND ALPHA(2)-ADRENERGIC RECEPTORS SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID SELECTIVE ALPHA-2-ADRENOCEPTOR AGONIST; ADRENERGIC ACTIVITIES; HEALTHY-VOLUNTEERS; HUMAN PLATELETS; MEDETOMIDINE; DEXMEDETOMIDINE; ADRENOCEPTORS; ANALOGS AB The naphthalene analog of medetomidine (1), 4-[1-(1-naphthyl)ethyl]-1H-imidazole (2), is a highly potent, selective alpha(2)-adrenoceptor agonist. We have initiated a structure-activity relationship study of the replacement of the methyl group on the carbon bridge between the naphthalene and imidazole rings of 2 with a hydrogen, hydroxy, methoxy, carbonyl, or trifluoromethyl group and compared their biological activities with medetomidine 1 and the optical isomers of 2. Analogs of 2 were antagonists of alpha(2A)-adrenoceptor-mediated human platelet aggregation and agonists on alpha(1)- and alpha(2)-adrenoceptors in guinea pig ileum. The rank order and potencies of these analogs on platelets (alpha(2A)-subtype) and guinea pig ileum (alpha(1)-subtype) were nearly the same, whereas racemic and S-(+)-2, desmethyl, and hydroxy analogs were potent agonists on alpha(2)-adrenoceptors in guinea pig ileum. With the exception of the desmethyl analog 5, none of the other analogs were as potent as the parent drug 2 on alpha(2A)- (human platelets), alpha(1)- (guinea pig ileum), or alpha(2)- (guinea pig ileum) adrenergic receptor systems. As with analog 2, the desmethyl- and methoxy-substituted analogs retained a greater alpha(2)/alpha(1)-selectivity in both functional (agonist activity) and biochemical (receptor displacement) studies. Receptor binding studies indicate that S-(+)-2 possessed greater affinity than the R-(-)-isomer on both alpha(1)- and alpha(2)-adrenoceptors in rat brain. In addition, R-(-)-2 did not show agonist activity in alpha(2)-adrenoceptors of guinea pig ileum and was 10-fold more potent than S-(+)-2 as an antagonist of alpha(2A)-adrenoceptors in human platelets. Thus, the nature of the substituent and the chirality at the carbon bridge between the naphthalene and imidazole rings play an important role in maintaining potent alpha(2)-adrenoceptor activity and high alpha(2)/alpha(1)-selectivity within the 4-substituted imidazole class. C1 UNIV TENNESSEE,COLL PHARM,DEPT PHARMACEUT SCI,MEMPHIS,TN 38163. OHIO STATE UNIV,COLL PHARM,DIV MED CHEM & PHARMACOGNOSY & PHARMACOL,COLUMBUS,OH 43210. USA,ABERDEEN PROVING GROUND,MD 21021. PROCTER & GAMBLE CO,CINCINNATI,OH 45239. FU NIGMS NIH HHS [GM-29358] NR 24 TC 14 Z9 14 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD JUL 22 PY 1994 VL 37 IS 15 BP 2328 EP 2333 DI 10.1021/jm00041a011 PG 6 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA NZ411 UT WOS:A1994NZ41100011 PM 7914537 ER PT J AU ZIMMERMAN, GC GRABSKI, WJ AF ZIMMERMAN, GC GRABSKI, WJ TI MALIGNANT-MELANOMA SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Note RP ZIMMERMAN, GC (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD JUL 21 PY 1994 VL 331 IS 3 BP 168 EP 168 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA NW797 UT WOS:A1994NW79700005 PM 8008030 ER EF